# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- 7tm_4 PF13853.6 EMC76724.1 - 9.5e-49 166.6 9.2 1.2e-48 166.3 9.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC76724.1 - 3.7e-29 101.9 15.4 6.4e-29 101.1 15.4 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC76724.1 - 0.0036 16.7 12.8 0.004 16.6 10.0 1.9 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx Nramp PF01566.18 EMC76726.1 - 2.5e-14 53.1 6.3 5.2e-10 38.8 0.9 2.9 2 1 1 3 3 3 2 Natural resistance-associated macrophage protein BTB PF00651.31 EMC76727.1 - 3.5e-28 98.1 0.3 5.8e-28 97.3 0.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain bZIP_Maf PF03131.17 EMC76727.1 - 4.5e-13 49.5 2.5 9.8e-13 48.4 2.5 1.6 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.21 EMC76727.1 - 1.2e-09 38.1 6.7 2.2e-09 37.2 6.7 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMC76727.1 - 1.6e-05 24.8 7.5 2.8e-05 24.1 7.5 1.4 1 0 0 1 1 1 1 Basic region leucine zipper DUF3342 PF11822.8 EMC76727.1 - 0.033 14.4 0.0 0.14 12.4 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) DUF1199 PF06712.11 EMC76727.1 - 1 9.5 3.2 1.3 9.1 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1199) Connexin PF00029.19 EMC76728.1 - 4.6e-99 330.9 0.1 5.2e-99 330.8 0.1 1.0 1 0 0 1 1 1 1 Connexin ADIP PF11559.8 EMC76729.1 - 0.0056 16.8 9.1 0.0056 16.8 9.1 7.1 8 0 0 8 8 8 1 Afadin- and alpha -actinin-Binding DUF2205 PF10224.9 EMC76729.1 - 0.028 14.4 2.7 0.16 12.0 2.7 2.4 1 0 0 1 1 1 0 Short coiled-coil protein Tachystatin_A PF11406.8 EMC76729.1 - 0.65 10.1 2.0 0.63 10.2 0.1 1.9 2 0 0 2 2 2 0 Antimicrobial peptide tachystatin A TSC22 PF01166.18 EMC76729.1 - 3.5 8.0 7.0 2 8.8 1.6 3.4 2 1 0 2 2 2 0 TSC-22/dip/bun family Complex1_LYR PF05347.15 EMC76730.1 - 4.6e-20 71.4 0.5 5.6e-20 71.1 0.5 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EMC76730.1 - 2.9e-09 37.5 0.5 3.8e-09 37.2 0.5 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 EMC76730.1 - 0.00022 21.7 0.3 0.00031 21.3 0.3 1.2 1 1 0 1 1 1 1 Complex1_LYR-like Ank_2 PF12796.7 EMC76731.1 - 1.1e-41 141.3 11.8 3.3e-12 46.8 0.2 4.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC76731.1 - 8e-41 137.9 17.5 7.9e-10 39.1 0.1 6.5 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC76731.1 - 9.1e-39 131.0 12.0 4.1e-10 39.7 0.1 5.7 2 2 4 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 EMC76731.1 - 2e-37 126.0 19.9 2e-08 34.3 0.3 7.7 8 0 0 8 8 8 6 Ankyrin repeat Ank_3 PF13606.6 EMC76731.1 - 1.5e-31 104.9 7.5 1.3e-05 25.2 0.1 8.0 8 0 0 8 8 8 6 Ankyrin repeat EccE PF11203.8 EMC76731.1 - 0.013 15.8 3.3 1.9 8.9 0.2 2.9 2 0 0 2 2 2 0 Putative type VII ESX secretion system translocon, EccE DUF445 PF04286.12 EMC76731.1 - 0.028 14.2 2.3 0.2 11.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF445) DUF5320 PF17253.2 EMC76731.1 - 0.22 12.6 1.2 0.85 10.7 1.2 2.0 1 0 0 1 1 1 0 Family of unknown function (DUF5320) Phasin PF05597.11 EMC76731.1 - 0.76 9.8 10.0 0.39 10.7 1.7 3.2 3 0 0 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Gtr1_RagA PF04670.12 EMC76732.1 - 6e-73 245.0 0.9 8.5e-73 244.5 0.9 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EMC76732.1 - 3.5e-07 29.9 0.0 4.9e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EMC76732.1 - 7.8e-06 25.4 0.1 1.8e-05 24.3 0.0 1.6 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EMC76732.1 - 2.7e-05 24.4 0.0 4.7e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMC76732.1 - 0.0015 18.1 0.0 0.0024 17.5 0.0 1.3 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 EMC76732.1 - 0.0089 16.1 0.0 0.026 14.6 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EMC76732.1 - 0.059 13.7 0.0 0.16 12.3 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain UQ_con PF00179.26 EMC76733.1 - 8.4e-18 64.4 0.0 1.4e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EMC76733.1 - 0.067 13.5 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 RWD domain Neur_chan_LBD PF02931.23 EMC76734.1 - 1e-51 175.4 0.6 1.8e-51 174.7 0.6 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC76734.1 - 8e-37 127.6 6.8 1.5e-32 113.6 1.5 3.1 2 1 1 3 3 3 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 EMC76735.1 - 1e-51 175.4 0.6 1.6e-51 174.8 0.6 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC76735.1 - 4.6e-36 125.1 5.7 4.3e-31 108.8 2.8 2.3 1 1 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region BORCS6 PF10157.9 EMC76736.1 - 8.5e-23 81.3 0.1 1e-22 81.0 0.1 1.2 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 6 PNRC PF15365.6 EMC76737.1 - 6.2e-07 29.0 6.9 6.2e-07 29.0 6.9 1.6 2 0 0 2 2 2 1 Proline-rich nuclear receptor coactivator motif DAZAP2 PF11029.8 EMC76737.1 - 0.062 14.2 2.3 0.089 13.7 2.3 1.3 1 1 0 1 1 1 0 DAZ associated protein 2 (DAZAP2) mRNA_cap_enzyme PF01331.19 EMC76738.1 - 1.7e-77 259.7 0.2 2.2e-77 259.3 0.2 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain DSPc PF00782.20 EMC76738.1 - 1.4e-10 41.1 0.0 2.6e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DNA_ligase_A_M PF01068.21 EMC76738.1 - 1.2e-06 28.3 0.0 0.0077 15.9 0.0 2.4 1 1 1 2 2 2 2 ATP dependent DNA ligase domain Y_phosphatase PF00102.27 EMC76738.1 - 0.00028 20.5 0.0 0.00044 19.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EMC76738.1 - 0.027 14.5 0.0 0.037 14.0 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 EMC76738.1 - 0.033 13.8 0.0 0.058 13.0 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Filament PF00038.21 EMC76739.1 - 1.9e-23 83.5 5.0 2.3e-23 83.3 5.0 1.1 1 0 0 1 1 1 1 Intermediate filament protein BRE1 PF08647.11 EMC76739.1 - 0.0013 18.7 1.4 0.002 18.1 1.4 1.3 1 0 0 1 1 1 1 BRE1 E3 ubiquitin ligase Zn-ribbon_8 PF09723.10 EMC76740.1 - 0.058 13.5 0.2 0.64 10.2 0.2 3.0 1 1 0 1 1 1 0 Zinc ribbon domain Filament PF00038.21 EMC76741.1 - 6e-106 354.5 39.7 7.1e-106 354.3 39.7 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.5 EMC76741.1 - 2.5e-15 57.0 121.6 6.6e-13 49.1 32.5 4.7 2 2 3 5 5 3 2 Keratin type II head ATG16 PF08614.11 EMC76741.1 - 9.6e-05 22.7 31.9 0.0011 19.3 7.6 2.5 1 1 0 2 2 2 2 Autophagy protein 16 (ATG16) AAA_13 PF13166.6 EMC76741.1 - 0.00012 21.0 16.6 0.00012 21.0 16.6 1.5 1 1 0 1 1 1 1 AAA domain TPR_MLP1_2 PF07926.12 EMC76741.1 - 0.00013 22.0 41.6 0.0024 18.0 4.4 3.5 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 EMC76741.1 - 0.00059 18.8 37.3 0.0011 17.9 11.7 3.0 1 1 2 3 3 3 2 Spc7 kinetochore protein JIP_LZII PF16471.5 EMC76741.1 - 0.04 14.1 23.5 0.17 12.1 0.7 5.0 4 2 1 5 5 5 0 JNK-interacting protein leucine zipper II Baculo_PEP_C PF04513.12 EMC76741.1 - 0.048 13.7 17.5 1.8 8.6 1.6 4.1 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus CENP-F_leu_zip PF10473.9 EMC76741.1 - 0.21 11.6 33.5 0.35 10.9 10.8 3.7 1 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Alanine_zipper PF11839.8 EMC76741.1 - 0.49 10.8 5.3 0.22 11.9 2.2 2.0 2 0 0 2 2 1 0 Alanine-zipper, major outer membrane lipoprotein LPP PF04728.13 EMC76741.1 - 0.8 10.1 9.8 0.48 10.9 0.6 3.8 4 0 0 4 4 3 0 Lipoprotein leucine-zipper Rx_N PF18052.1 EMC76741.1 - 1.7 9.0 6.4 26 5.2 1.9 3.0 2 1 0 2 2 2 0 Rx N-terminal domain FPP PF05911.11 EMC76741.1 - 2.1 6.4 28.7 8.9 4.4 28.7 1.9 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil FapA PF03961.13 EMC76741.1 - 2.6 6.5 27.6 0.4 9.2 6.8 2.4 1 1 2 3 3 3 0 Flagellar Assembly Protein A Asp2 PF16929.5 EMC76741.1 - 3 6.7 11.9 1.2 8.1 8.8 1.9 1 1 0 1 1 1 0 Accessory Sec system GspB-transporter Fib_alpha PF08702.10 EMC76741.1 - 3.1 8.0 28.2 0.14 12.3 5.5 3.3 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family AKNA PF12443.8 EMC76741.1 - 3.8 8.2 7.5 2.4 8.9 1.5 2.6 2 0 0 2 2 2 0 AT-hook-containing transcription factor DUF4407 PF14362.6 EMC76741.1 - 4.5 6.5 26.6 2.5 7.4 5.5 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) FUSC PF04632.12 EMC76741.1 - 7.7 4.9 8.7 3.1 6.2 4.7 1.9 2 0 0 2 2 2 0 Fusaric acid resistance protein family Jnk-SapK_ap_N PF09744.9 EMC76741.1 - 8.5 6.6 35.7 0.18 12.0 5.0 3.8 2 1 2 4 4 4 0 JNK_SAPK-associated protein-1 Filament PF00038.21 EMC76742.1 - 4.6e-103 345.1 37.0 5.4e-103 344.8 37.0 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.5 EMC76742.1 - 5.6e-17 62.3 52.9 5.6e-17 62.3 52.9 3.7 2 1 1 3 3 3 1 Keratin type II head Spc7 PF08317.11 EMC76742.1 - 6.4e-05 22.0 31.9 0.00066 18.6 8.8 2.7 1 1 2 3 3 3 3 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 EMC76742.1 - 0.00015 21.8 36.1 0.0038 17.3 13.5 3.4 4 0 0 4 4 3 2 TPR/MLP1/MLP2-like protein AAA_13 PF13166.6 EMC76742.1 - 0.00027 19.7 12.8 0.00027 19.7 12.8 1.5 1 1 0 1 1 1 1 AAA domain ATG16 PF08614.11 EMC76742.1 - 0.0003 21.1 26.8 0.0013 19.0 3.1 2.4 1 1 0 2 2 2 2 Autophagy protein 16 (ATG16) Baculo_PEP_C PF04513.12 EMC76742.1 - 0.0014 18.7 7.0 0.61 10.1 2.1 3.6 1 1 2 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus LPP PF04728.13 EMC76742.1 - 0.004 17.5 2.9 0.041 14.3 0.3 3.5 4 0 0 4 4 3 1 Lipoprotein leucine-zipper JIP_LZII PF16471.5 EMC76742.1 - 0.0089 16.2 23.1 0.1 12.8 0.4 4.8 5 0 0 5 5 5 2 JNK-interacting protein leucine zipper II DASH_Dam1 PF08653.10 EMC76742.1 - 0.075 12.8 1.0 87 3.0 0.1 3.8 4 0 0 4 4 3 0 DASH complex subunit Dam1 CENP-F_leu_zip PF10473.9 EMC76742.1 - 0.078 13.0 31.7 0.25 11.4 11.7 3.9 1 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Asp2 PF16929.5 EMC76742.1 - 0.093 11.7 8.5 0.036 13.0 5.4 1.9 1 1 0 1 1 1 0 Accessory Sec system GspB-transporter Tropomyosin_1 PF12718.7 EMC76742.1 - 0.12 12.6 28.2 1.1 9.4 2.6 3.2 2 1 1 3 3 3 0 Tropomyosin like ADIP PF11559.8 EMC76742.1 - 0.53 10.4 28.7 1.3 9.1 5.8 3.3 2 2 1 3 3 3 0 Afadin- and alpha -actinin-Binding DUF1664 PF07889.12 EMC76742.1 - 0.8 9.8 18.9 0.21 11.6 2.5 3.9 3 1 0 4 4 4 0 Protein of unknown function (DUF1664) DUF883 PF05957.13 EMC76742.1 - 0.84 10.3 16.1 4.2 8.0 5.5 3.6 4 0 0 4 4 3 0 Bacterial protein of unknown function (DUF883) CHDCT2 PF08074.11 EMC76742.1 - 1 9.5 14.2 0.75 9.9 2.3 2.7 1 1 0 2 2 2 0 CHDCT2 (NUC038) domain BicD PF09730.9 EMC76742.1 - 1.9 6.8 26.6 0.41 9.0 13.6 2.3 1 1 0 2 2 2 0 Microtubule-associated protein Bicaudal-D FlaC_arch PF05377.11 EMC76742.1 - 2.3 8.7 18.5 0.19 12.1 0.4 5.4 6 0 0 6 6 6 0 Flagella accessory protein C (FlaC) DUF4530 PF15039.6 EMC76742.1 - 2.5 8.3 7.3 0.17 12.1 0.5 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4530) BLOC1_2 PF10046.9 EMC76742.1 - 2.6 8.4 15.7 1.9 8.8 0.6 4.1 3 2 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CALCOCO1 PF07888.11 EMC76742.1 - 3.5 6.4 32.8 2.1 7.1 26.3 2.2 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Fib_alpha PF08702.10 EMC76742.1 - 3.5 7.8 23.1 0.075 13.2 1.4 3.4 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family FapA PF03961.13 EMC76742.1 - 4 5.9 24.7 0.85 8.1 4.2 2.5 1 1 2 3 3 3 0 Flagellar Assembly Protein A bZIP_1 PF00170.21 EMC76742.1 - 4.7 7.4 27.5 0.91 9.7 1.8 5.2 5 0 0 5 5 5 0 bZIP transcription factor ApoO PF09769.9 EMC76742.1 - 6.1 6.8 7.8 7.6 6.5 0.1 3.5 3 1 0 3 3 3 0 Apolipoprotein O YabA PF06156.13 EMC76742.1 - 6.7 7.4 33.4 7.2 7.3 2.1 5.0 2 2 3 5 5 5 0 Initiation control protein YabA She9_MDM33 PF05546.11 EMC76742.1 - 7.5 6.3 16.0 0.33 10.7 1.3 2.9 2 1 0 2 2 2 0 She9 / Mdm33 family UPF0242 PF06785.11 EMC76742.1 - 7.9 6.5 32.6 9.3 6.3 2.8 3.3 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus YlqD PF11068.8 EMC76742.1 - 8 6.9 29.9 0.25 11.7 0.3 3.9 3 1 1 4 4 4 0 YlqD protein DUF2721 PF11026.8 EMC76742.1 - 8.1 6.3 8.0 1.7 8.5 0.0 3.2 2 2 1 3 3 3 0 Protein of unknown function (DUF2721) HALZ PF02183.18 EMC76742.1 - 9.1 6.6 14.6 0.6 10.4 0.2 3.9 4 0 0 4 4 3 0 Homeobox associated leucine zipper Filament PF00038.21 EMC76743.1 - 1.5e-82 277.7 35.7 1.7e-82 277.5 35.7 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.5 EMC76743.1 - 8.4e-16 58.5 15.5 8.4e-16 58.5 15.5 3.1 2 1 0 2 2 1 1 Keratin type II head V_ATPase_I PF01496.19 EMC76743.1 - 0.00088 17.3 0.4 0.00088 17.3 0.4 2.2 2 0 0 2 2 2 1 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 EMC76743.1 - 0.0023 17.3 20.5 0.0058 16.0 8.9 2.5 2 1 0 2 2 2 2 Domain of unknown function (DUF4407) DivIC PF04977.15 EMC76743.1 - 0.0026 17.5 2.3 0.0026 17.5 2.3 5.5 3 2 3 6 6 6 1 Septum formation initiator TPR_MLP1_2 PF07926.12 EMC76743.1 - 0.0066 16.5 2.4 0.0066 16.5 2.4 3.8 3 1 1 4 4 4 1 TPR/MLP1/MLP2-like protein Syntaxin_2 PF14523.6 EMC76743.1 - 0.027 14.8 1.1 0.027 14.8 1.1 3.0 3 1 0 3 3 2 0 Syntaxin-like protein CENP-F_leu_zip PF10473.9 EMC76743.1 - 0.029 14.4 32.9 0.033 14.2 11.1 3.4 1 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 EMC76743.1 - 0.033 14.4 31.6 0.58 10.4 14.1 3.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) YabA PF06156.13 EMC76743.1 - 0.08 13.6 24.7 1.1 9.9 0.3 4.8 1 1 4 5 5 5 0 Initiation control protein YabA WXG100 PF06013.12 EMC76743.1 - 0.14 12.4 11.5 5.1 7.4 0.1 4.0 2 1 1 3 3 3 0 Proteins of 100 residues with WXG Syntaxin-6_N PF09177.11 EMC76743.1 - 0.17 12.4 14.5 1.8 9.1 2.1 3.6 2 1 1 3 3 3 0 Syntaxin 6, N-terminal DUF4140 PF13600.6 EMC76743.1 - 0.35 11.3 30.1 2.8 8.5 0.1 5.3 2 2 3 5 5 5 0 N-terminal domain of unknown function (DUF4140) Spc7 PF08317.11 EMC76743.1 - 0.38 9.6 30.5 0.66 8.8 7.6 3.5 1 1 2 3 3 3 0 Spc7 kinetochore protein GldM_N PF12081.8 EMC76743.1 - 0.69 10.0 5.9 2.6 8.1 0.4 2.6 2 1 0 3 3 3 0 GldM N-terminal domain DUF3584 PF12128.8 EMC76743.1 - 1.1 6.7 30.6 1.9 5.9 30.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) JIP_LZII PF16471.5 EMC76743.1 - 1.1 9.4 15.5 1.9 8.7 0.1 4.6 4 1 0 4 4 4 0 JNK-interacting protein leucine zipper II NPV_P10 PF05531.12 EMC76743.1 - 1.2 9.6 8.1 68 4.0 0.1 4.5 3 2 2 5 5 5 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.12 EMC76743.1 - 1.5 9.5 26.1 0.44 11.2 2.6 4.9 3 1 1 4 4 4 0 SlyX GAS PF13851.6 EMC76743.1 - 1.7 8.0 30.7 0.13 11.6 6.4 3.1 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding CENP-H PF05837.12 EMC76743.1 - 1.9 9.0 20.6 0.16 12.4 4.8 3.1 2 1 1 3 3 3 0 Centromere protein H (CENP-H) Fib_alpha PF08702.10 EMC76743.1 - 2 8.6 18.3 1.8 8.7 3.3 3.4 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family TMPIT PF07851.13 EMC76743.1 - 3.1 6.9 12.5 0.13 11.5 0.5 2.5 2 1 1 3 3 3 0 TMPIT-like protein Tropomyosin_1 PF12718.7 EMC76743.1 - 3.3 7.9 24.6 0.92 9.7 3.2 2.8 2 1 0 2 2 2 0 Tropomyosin like FlaC_arch PF05377.11 EMC76743.1 - 4.7 7.7 14.2 2.5 8.6 0.3 4.7 6 0 0 6 6 4 0 Flagella accessory protein C (FlaC) FUSC PF04632.12 EMC76743.1 - 4.9 5.6 18.2 1.4 7.3 8.2 2.1 2 0 0 2 2 2 0 Fusaric acid resistance protein family SKA2 PF16740.5 EMC76743.1 - 5.4 6.8 14.4 0.26 11.1 2.3 3.6 2 2 0 3 3 3 0 Spindle and kinetochore-associated protein 2 Atg14 PF10186.9 EMC76743.1 - 6.3 5.8 18.4 0.096 11.7 5.1 2.3 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 FapA PF03961.13 EMC76743.1 - 6.8 5.2 15.0 1.2 7.7 2.8 2.5 1 1 0 2 2 2 0 Flagellar Assembly Protein A BLOC1_2 PF10046.9 EMC76743.1 - 7.1 7.0 14.8 8.7 6.7 0.4 4.5 3 2 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Filament PF00038.21 EMC76744.1 - 1.3e-89 300.8 27.9 1.5e-89 300.7 27.9 1.0 1 0 0 1 1 1 1 Intermediate filament protein CENP-F_leu_zip PF10473.9 EMC76744.1 - 0.00039 20.4 6.7 0.00039 20.4 6.7 3.4 1 1 2 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 EMC76744.1 - 0.0044 17.3 18.7 0.019 15.2 10.5 3.1 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 EMC76744.1 - 0.013 15.6 20.8 0.048 13.7 0.1 3.8 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein cwf21 PF08312.12 EMC76744.1 - 0.053 13.7 0.7 0.053 13.7 0.7 3.5 2 2 1 3 3 3 0 cwf21 domain Baculo_PEP_C PF04513.12 EMC76744.1 - 0.062 13.3 0.5 0.062 13.3 0.5 2.8 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 EMC76744.1 - 0.077 13.0 10.8 1.5 8.9 1.9 3.4 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) DUF3502 PF12010.8 EMC76744.1 - 0.11 13.2 1.3 4.3 8.0 1.3 2.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3502) DUF883 PF05957.13 EMC76744.1 - 0.5 11.0 6.5 7.8 7.2 1.8 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF4407 PF14362.6 EMC76744.1 - 0.8 9.0 16.1 1.6 8.1 9.6 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 EMC76744.1 - 1.2 7.9 26.1 0.95 8.3 5.6 2.8 1 1 1 2 2 2 0 Spc7 kinetochore protein AKNA PF12443.8 EMC76744.1 - 1.4 9.6 5.0 1.5 9.5 1.4 2.7 1 1 1 2 2 2 0 AT-hook-containing transcription factor BBP1_C PF15272.6 EMC76744.1 - 2.5 7.9 17.0 0.52 10.1 1.8 3.4 2 2 1 3 3 3 0 Spindle pole body component BBP1, C-terminal DUF5344 PF17279.2 EMC76744.1 - 2.9 8.6 6.5 0.98 10.0 0.3 3.2 3 1 1 4 4 3 0 Family of unknown function (DUF5344) DUF5082 PF16888.5 EMC76744.1 - 3.2 8.1 18.6 5.2 7.4 5.6 3.9 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) PI3K_P85_iSH2 PF16454.5 EMC76744.1 - 5.2 6.6 22.5 8.4 6.0 17.2 3.3 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain GIT_CC PF16559.5 EMC76744.1 - 5.8 6.9 10.6 0.21 11.5 0.5 3.4 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor Occludin_ELL PF07303.13 EMC76744.1 - 6.1 7.6 14.3 0.055 14.2 3.0 2.9 3 1 0 3 3 3 0 Occludin homology domain Filament PF00038.21 EMC76745.1 - 2e-111 372.5 28.5 2.3e-111 372.3 28.5 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.5 EMC76745.1 - 4.5e-34 117.9 53.3 4.5e-34 117.9 53.3 2.5 2 1 0 2 2 1 1 Keratin type II head ATG16 PF08614.11 EMC76745.1 - 7.5e-05 23.0 22.5 0.0014 18.9 2.1 2.9 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) Spc7 PF08317.11 EMC76745.1 - 0.0019 17.1 3.3 0.0019 17.1 3.3 3.1 1 1 1 2 2 2 1 Spc7 kinetochore protein Vps53_N PF04100.12 EMC76745.1 - 0.0035 16.4 2.6 0.0035 16.4 2.6 1.8 2 0 0 2 2 2 1 Vps53-like, N-terminal COG5 PF10392.9 EMC76745.1 - 0.0041 17.3 1.4 0.011 16.0 1.4 1.7 1 0 0 1 1 1 1 Golgi transport complex subunit 5 TPR_MLP1_2 PF07926.12 EMC76745.1 - 0.0081 16.2 0.7 0.0081 16.2 0.7 3.7 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein Baculo_PEP_C PF04513.12 EMC76745.1 - 0.014 15.5 0.7 0.014 15.5 0.7 3.8 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus CENP-F_leu_zip PF10473.9 EMC76745.1 - 0.016 15.3 19.0 0.49 10.4 3.0 3.1 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Taxilin PF09728.9 EMC76745.1 - 0.016 14.4 17.5 0.15 11.3 8.3 2.8 1 1 2 3 3 3 0 Myosin-like coiled-coil protein Tropomyosin_1 PF12718.7 EMC76745.1 - 0.53 10.4 23.6 0.39 10.9 9.3 2.9 2 1 1 3 3 3 0 Tropomyosin like BRE1 PF08647.11 EMC76745.1 - 0.53 10.4 24.3 0.05 13.7 5.1 4.4 3 2 2 5 5 5 0 BRE1 E3 ubiquitin ligase Lebercilin PF15619.6 EMC76745.1 - 0.61 9.7 23.2 0.02 14.5 8.1 3.3 1 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease TraC PF07820.12 EMC76745.1 - 1.3 9.4 8.4 4.4 7.7 4.6 2.9 2 0 0 2 2 2 0 TraC-like protein KxDL PF10241.9 EMC76745.1 - 1.3 9.3 8.9 4.1 7.8 0.2 4.2 2 1 3 5 5 5 0 Uncharacterized conserved protein TSC22 PF01166.18 EMC76745.1 - 2.9 8.3 13.7 6.2 7.2 0.3 4.4 3 1 1 4 4 4 0 TSC-22/dip/bun family Rootletin PF15035.6 EMC76745.1 - 3.4 7.7 19.3 4.4 7.3 8.4 2.3 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion ApoLp-III PF07464.11 EMC76745.1 - 4 7.5 13.1 0.16 12.1 2.1 3.3 2 1 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Golgin_A5 PF09787.9 EMC76745.1 - 4.4 6.7 22.9 0.77 9.2 7.0 2.8 1 1 2 3 3 3 0 Golgin subfamily A member 5 NPV_P10 PF05531.12 EMC76745.1 - 5.2 7.6 10.2 3 8.4 0.4 3.6 3 2 0 3 3 3 0 Nucleopolyhedrovirus P10 protein ADIP PF11559.8 EMC76745.1 - 9.6 6.3 24.1 2.6 8.1 7.2 3.9 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding PCRF PF03462.18 EMC76746.1 - 0.0046 16.9 0.1 2.1 8.2 0.0 2.4 1 1 1 2 2 2 2 PCRF domain HetR_C PF18460.1 EMC76746.1 - 0.46 10.4 15.3 53 3.8 0.5 5.5 1 1 6 7 7 7 0 Heterocyst differentiation regulator C-terminal Hood domain CUT PF02376.15 EMC76746.1 - 1.8 8.8 12.6 60 3.9 0.1 4.6 1 1 1 2 2 2 0 CUT domain Filament PF00038.21 EMC76747.1 - 4.5e-115 384.5 35.6 5.2e-115 384.3 35.6 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.5 EMC76747.1 - 1e-43 149.2 53.1 1.4e-43 148.9 53.1 1.1 1 0 0 1 1 1 1 Keratin type II head TPR_MLP1_2 PF07926.12 EMC76747.1 - 7.1e-07 29.3 28.9 0.001 19.1 0.6 3.8 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein AAA_13 PF13166.6 EMC76747.1 - 1.9e-05 23.6 13.5 1.9e-05 23.6 13.5 1.9 1 1 1 2 2 2 1 AAA domain Spc7 PF08317.11 EMC76747.1 - 0.0004 19.4 32.3 0.0023 16.9 8.5 3.3 1 1 3 4 4 4 3 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 EMC76747.1 - 0.0034 17.4 28.2 0.057 13.4 8.7 3.7 1 1 3 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Jnk-SapK_ap_N PF09744.9 EMC76747.1 - 0.0058 16.9 2.4 0.0058 16.9 2.4 3.4 1 1 1 3 3 3 1 JNK_SAPK-associated protein-1 Baculo_PEP_C PF04513.12 EMC76747.1 - 0.0093 16.0 0.6 0.0093 16.0 0.6 4.5 1 1 3 4 4 4 2 Baculovirus polyhedron envelope protein, PEP, C terminus ApoLp-III PF07464.11 EMC76747.1 - 0.011 15.9 2.2 0.011 15.9 2.2 3.3 1 1 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) BRE1 PF08647.11 EMC76747.1 - 0.012 15.6 4.4 0.012 15.6 4.4 4.9 2 1 2 5 5 5 0 BRE1 E3 ubiquitin ligase MukF_M PF17192.4 EMC76747.1 - 0.014 15.1 14.8 0.11 12.3 6.9 2.4 2 0 0 2 2 2 0 MukF middle domain DUF4407 PF14362.6 EMC76747.1 - 0.024 14.0 0.5 0.024 14.0 0.5 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 EMC76747.1 - 0.092 12.8 16.6 1.4 9.0 0.2 4.4 3 1 0 4 4 4 0 Protein of unknown function (DUF1664) DUF1451 PF07295.11 EMC76747.1 - 0.12 12.4 15.0 0.14 12.2 2.7 2.8 2 1 0 2 2 2 0 Zinc-ribbon containing domain ADIP PF11559.8 EMC76747.1 - 0.18 11.9 28.5 0.75 9.9 9.0 3.9 1 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Rx_N PF18052.1 EMC76747.1 - 0.2 12.0 9.8 1.1 9.5 3.0 3.0 3 0 0 3 3 3 0 Rx N-terminal domain ISG65-75 PF11727.8 EMC76747.1 - 0.57 9.4 9.0 0.33 10.1 4.2 2.2 2 0 0 2 2 2 0 Invariant surface glycoprotein ACCA PF03255.14 EMC76747.1 - 0.6 10.0 18.7 0.41 10.5 0.8 3.7 1 1 2 4 4 4 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Phage_GP20 PF06810.11 EMC76747.1 - 0.66 9.8 22.9 0.5 10.2 6.5 4.2 2 1 1 3 3 3 0 Phage minor structural protein GP20 Rootletin PF15035.6 EMC76747.1 - 1.2 9.2 24.3 0.28 11.2 4.3 2.3 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF5082 PF16888.5 EMC76747.1 - 1.6 9.0 23.7 0.8 10.0 4.8 3.8 1 1 3 4 4 4 0 Domain of unknown function (DUF5082) COMP PF11598.8 EMC76747.1 - 1.7 9.2 6.5 48 4.5 0.1 4.4 5 0 0 5 5 3 0 Cartilage oligomeric matrix protein TSC22 PF01166.18 EMC76747.1 - 2.7 8.4 14.8 4.6 7.6 0.3 4.7 3 2 1 4 4 4 0 TSC-22/dip/bun family Ax_dynein_light PF10211.9 EMC76747.1 - 3.2 7.7 29.1 0.31 11.0 6.7 4.2 1 1 3 4 4 4 0 Axonemal dynein light chain FapA PF03961.13 EMC76747.1 - 4.2 5.9 20.2 1.3 7.5 3.2 2.3 1 1 0 2 2 2 0 Flagellar Assembly Protein A PEARLI-4 PF05278.12 EMC76747.1 - 4.4 6.8 18.6 1.3 8.5 3.8 3.4 1 1 3 4 4 4 0 Arabidopsis phospholipase-like protein (PEARLI 4) PRESAN PF09687.10 EMC76747.1 - 6.9 7.3 8.1 1.9 9.1 0.3 3.0 3 1 1 4 4 3 0 Plasmodium RESA N-terminal CHDCT2 PF08074.11 EMC76747.1 - 7.5 6.7 15.2 2.6 8.2 3.5 2.9 1 1 1 3 3 3 0 CHDCT2 (NUC038) domain DOR PF14839.6 EMC76747.1 - 8.8 6.2 8.7 0.19 11.6 0.3 2.2 2 1 1 3 3 3 0 DOR family APG6_N PF17675.1 EMC76747.1 - 9 6.8 37.1 0.3 11.6 12.3 4.1 1 1 3 4 4 4 0 Apg6 coiled-coil region DUF948 PF06103.11 EMC76747.1 - 9.2 6.6 11.8 3.3 8.0 0.7 3.6 3 1 1 4 4 3 0 Bacterial protein of unknown function (DUF948) Filament PF00038.21 EMC76748.1 - 7.9e-112 373.9 33.7 9.3e-112 373.6 33.7 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.5 EMC76748.1 - 8.7e-23 81.2 46.1 7.7e-21 74.9 27.9 3.2 2 1 0 2 2 2 1 Keratin type II head TPR_MLP1_2 PF07926.12 EMC76748.1 - 4.1e-07 30.1 45.6 6.3e-06 26.3 10.7 4.0 2 2 2 4 4 4 2 TPR/MLP1/MLP2-like protein Taxilin PF09728.9 EMC76748.1 - 2.7e-06 26.8 14.4 6e-05 22.4 13.8 2.7 1 1 0 1 1 1 1 Myosin-like coiled-coil protein Spc7 PF08317.11 EMC76748.1 - 0.00082 18.3 2.8 0.00082 18.3 2.8 3.5 1 1 2 3 3 3 2 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 EMC76748.1 - 0.001 19.1 5.1 0.001 19.1 5.1 3.8 2 2 2 4 4 4 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tropomyosin_1 PF12718.7 EMC76748.1 - 0.0029 17.8 8.8 0.0029 17.8 8.8 3.6 2 1 1 3 3 3 1 Tropomyosin like ADIP PF11559.8 EMC76748.1 - 0.0029 17.7 29.4 0.07 13.2 7.9 4.2 1 1 2 3 3 3 1 Afadin- and alpha -actinin-Binding DUF4407 PF14362.6 EMC76748.1 - 0.0068 15.8 27.4 0.053 12.9 5.6 2.8 1 1 1 2 2 2 2 Domain of unknown function (DUF4407) APG6_N PF17675.1 EMC76748.1 - 0.009 16.5 44.6 0.033 14.7 3.9 4.3 2 1 1 4 4 4 2 Apg6 coiled-coil region BRE1 PF08647.11 EMC76748.1 - 0.011 15.7 4.1 0.011 15.7 4.1 4.7 3 2 2 5 5 5 0 BRE1 E3 ubiquitin ligase TSNAXIP1_N PF15739.5 EMC76748.1 - 0.019 15.3 1.0 0.019 15.3 1.0 4.4 3 1 2 5 5 5 0 Translin-associated factor X-interacting N-terminus DUF1664 PF07889.12 EMC76748.1 - 0.025 14.6 15.8 0.038 14.0 0.3 4.5 3 1 2 5 5 5 0 Protein of unknown function (DUF1664) DUF2746 PF10874.8 EMC76748.1 - 0.038 14.4 0.4 2.9 8.4 0.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2746) VirD1 PF07328.11 EMC76748.1 - 0.05 13.6 0.0 0.16 11.9 0.0 1.9 1 0 0 1 1 1 0 T-DNA border endonuclease VirD1 Spc29 PF17082.5 EMC76748.1 - 0.053 13.4 15.7 0.017 15.0 8.6 2.4 1 1 1 2 2 2 0 Spindle Pole Component 29 BLOC1_2 PF10046.9 EMC76748.1 - 0.056 13.7 19.1 0.46 10.8 0.1 4.8 2 2 0 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 LPP PF04728.13 EMC76748.1 - 0.058 13.8 0.1 0.058 13.8 0.1 5.0 4 1 1 5 5 5 0 Lipoprotein leucine-zipper ATG16 PF08614.11 EMC76748.1 - 0.061 13.5 33.8 0.26 11.5 2.5 3.7 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) GAS PF13851.6 EMC76748.1 - 0.094 12.1 32.6 0.11 11.8 7.4 3.6 2 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding SlyX PF04102.12 EMC76748.1 - 0.11 13.2 0.2 0.11 13.2 0.2 5.1 4 2 1 5 5 5 0 SlyX DUF4254 PF14063.6 EMC76748.1 - 0.15 11.9 0.1 0.15 11.9 0.1 3.3 2 2 2 4 4 4 0 Protein of unknown function (DUF4254) Golgin_A5 PF09787.9 EMC76748.1 - 0.16 11.4 30.4 0.043 13.3 7.6 3.0 1 1 2 3 3 3 0 Golgin subfamily A member 5 DUF3584 PF12128.8 EMC76748.1 - 0.2 9.1 30.1 0.18 9.3 25.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Bap31_Bap29_C PF18035.1 EMC76748.1 - 0.2 11.7 0.1 0.2 11.7 0.1 4.1 4 2 0 4 4 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain Jnk-SapK_ap_N PF09744.9 EMC76748.1 - 0.57 10.4 33.2 0.32 11.2 9.4 3.4 1 1 3 4 4 4 0 JNK_SAPK-associated protein-1 SOGA PF11365.8 EMC76748.1 - 0.62 11.2 21.2 0.73 11.0 3.4 3.6 2 1 3 5 5 4 0 Protein SOGA DUF3450 PF11932.8 EMC76748.1 - 0.69 9.2 32.0 0.04 13.2 2.9 4.3 1 1 2 4 4 4 0 Protein of unknown function (DUF3450) TMF_TATA_bd PF12325.8 EMC76748.1 - 0.82 9.9 31.0 2.5 8.4 5.5 5.3 2 1 3 5 5 5 0 TATA element modulatory factor 1 TATA binding FapA PF03961.13 EMC76748.1 - 0.88 8.1 20.9 0.83 8.2 4.5 2.7 1 1 2 3 3 3 0 Flagellar Assembly Protein A Fez1 PF06818.15 EMC76748.1 - 0.99 9.8 27.2 0.051 14.0 10.9 2.7 1 1 2 3 3 3 0 Fez1 FlaC_arch PF05377.11 EMC76748.1 - 1 9.8 14.1 2.2 8.7 0.1 5.6 4 1 1 6 6 5 0 Flagella accessory protein C (FlaC) Fib_alpha PF08702.10 EMC76748.1 - 1.2 9.3 23.1 0.66 10.2 3.2 3.9 1 1 2 4 4 4 0 Fibrinogen alpha/beta chain family Phage_GP20 PF06810.11 EMC76748.1 - 1.2 8.9 25.2 0.02 14.7 4.8 4.2 2 1 1 3 3 3 0 Phage minor structural protein GP20 JIP_LZII PF16471.5 EMC76748.1 - 1.6 9.0 19.8 8.6 6.6 0.5 5.1 4 1 1 5 5 4 0 JNK-interacting protein leucine zipper II DUF948 PF06103.11 EMC76748.1 - 1.8 8.9 8.8 2.5 8.4 0.5 4.0 3 2 1 4 4 3 0 Bacterial protein of unknown function (DUF948) Ribosomal_S30AE PF02482.19 EMC76748.1 - 1.9 9.3 5.5 1.4 9.7 2.0 2.5 1 1 0 2 2 2 0 Sigma 54 modulation protein / S30EA ribosomal protein YabA PF06156.13 EMC76748.1 - 1.9 9.2 26.6 7.3 7.3 1.5 5.0 1 1 4 5 5 5 0 Initiation control protein YabA TMPIT PF07851.13 EMC76748.1 - 1.9 7.7 18.8 0.27 10.4 2.5 2.8 2 1 1 3 3 3 0 TMPIT-like protein Seryl_tRNA_N PF02403.22 EMC76748.1 - 1.9 8.7 28.3 0.16 12.2 6.2 3.7 1 1 3 4 4 4 0 Seryl-tRNA synthetase N-terminal domain UPF0242 PF06785.11 EMC76748.1 - 2.3 8.3 32.3 2.1 8.4 1.3 3.4 2 2 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Plk4_PB2 PF18409.1 EMC76748.1 - 2.5 8.8 7.6 2.7 8.7 0.2 3.3 1 1 2 3 3 3 0 Polo-like Kinase 4 Polo Box 2 RPW8 PF05659.11 EMC76748.1 - 2.7 7.7 8.1 5.8 6.6 0.1 3.9 1 1 2 4 4 4 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 MukF_M PF17192.4 EMC76748.1 - 3.6 7.3 15.4 0.16 11.7 0.8 2.8 1 1 0 2 2 2 0 MukF middle domain DASH_Spc19 PF08287.11 EMC76748.1 - 3.9 7.3 25.0 0.99 9.3 2.7 3.4 2 1 2 4 4 4 0 Spc19 Nbl1_Borealin_N PF10444.9 EMC76748.1 - 4 7.2 13.8 0.18 11.5 0.2 4.8 5 1 0 5 5 4 0 Nbl1 / Borealin N terminal DUF4164 PF13747.6 EMC76748.1 - 4.3 7.7 24.0 0.19 12.0 3.4 4.5 2 2 2 4 4 4 0 Domain of unknown function (DUF4164) MAD PF05557.13 EMC76748.1 - 4.4 5.6 32.1 0.0083 14.5 15.3 2.8 1 1 1 3 3 3 0 Mitotic checkpoint protein Cob_adeno_trans PF01923.18 EMC76748.1 - 4.8 7.3 13.2 2.7 8.1 6.9 3.1 1 1 2 3 3 3 0 Cobalamin adenosyltransferase Baculo_PEP_C PF04513.12 EMC76748.1 - 5 7.2 20.4 0.78 9.8 1.2 4.0 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Rootletin PF15035.6 EMC76748.1 - 5.2 7.0 25.3 3.5 7.6 4.5 2.4 1 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion TMF_DNA_bd PF12329.8 EMC76748.1 - 6.3 6.9 30.1 0.053 13.5 1.5 5.3 4 1 1 5 5 5 0 TATA element modulatory factor 1 DNA binding DUF4988 PF16378.5 EMC76748.1 - 6.9 6.3 6.3 35 4.0 0.2 3.2 3 1 0 3 3 3 0 Domain of unknown function CdiI_2 PF18593.1 EMC76748.1 - 7.1 7.4 8.6 3.7 8.3 0.2 3.8 4 1 0 4 4 3 0 CdiI immunity protein Alanine_zipper PF11839.8 EMC76748.1 - 8.3 6.9 14.7 0.82 10.1 7.6 2.8 3 0 0 3 3 2 0 Alanine-zipper, major outer membrane lipoprotein ZapB PF06005.12 EMC76748.1 - 9.9 6.7 36.1 20 5.7 12.0 5.4 3 2 0 3 3 1 0 Cell division protein ZapB Sugarporin_N PF11471.8 EMC76748.1 - 10 6.2 13.6 20 5.2 7.8 2.8 1 1 1 2 2 2 0 Maltoporin periplasmic N-terminal extension Bin3 PF06859.12 EMC76749.1 - 7.7e-19 68.3 0.0 1.1e-18 67.8 0.0 1.3 1 0 0 1 1 1 1 Bicoid-interacting protein 3 (Bin3) Methyltransf_12 PF08242.12 EMC76749.1 - 0.0054 17.4 0.0 0.11 13.2 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC76749.1 - 0.051 13.4 0.0 0.065 13.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 EMC76749.1 - 0.091 13.4 0.0 0.3 11.7 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain MIP PF00230.20 EMC76750.1 - 9.8e-74 247.9 18.8 1.2e-73 247.6 18.8 1.0 1 0 0 1 1 1 1 Major intrinsic protein Hormone_2 PF00123.20 EMC76751.1 - 5.3e-11 42.2 0.4 2.3e-10 40.2 0.0 2.0 2 0 0 2 2 2 1 Peptide hormone HCO3_cotransp PF00955.21 EMC76752.1 - 7e-242 803.7 6.4 9e-242 803.4 6.4 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 EMC76752.1 - 7.5e-101 337.4 0.0 1.6e-100 336.4 0.0 1.6 1 0 0 1 1 1 1 Band 3 cytoplasmic domain DUF3796 PF12676.7 EMC76752.1 - 0.91 10.0 5.4 3.3 8.2 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3796) FUSC-like PF12805.7 EMC76752.1 - 9.2 5.2 7.0 1.7 7.7 0.0 2.8 3 0 0 3 3 3 0 FUSC-like inner membrane protein yccS DAZAP2 PF11029.8 EMC76754.1 - 1.7e-06 29.0 0.1 1.8e-06 28.9 0.1 1.0 1 0 0 1 1 1 1 DAZ associated protein 2 (DAZAP2) Collagen PF01391.18 EMC76755.1 - 7.7e-91 297.8 344.5 5.5e-08 32.5 24.2 12.5 1 1 2 3 3 3 2 Collagen triple helix repeat (20 copies) DnaJ_C PF01556.18 EMC76757.1 - 4.5e-44 150.1 0.4 6.2e-44 149.7 0.4 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EMC76757.1 - 1.1e-26 92.7 2.1 2.1e-26 91.8 2.1 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EMC76757.1 - 6e-15 55.3 20.7 1.1e-14 54.5 20.7 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EMC76757.1 - 0.026 14.5 11.7 0.57 10.2 4.5 2.7 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EMC76757.1 - 0.082 12.9 7.5 0.92 9.5 0.8 2.4 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA WD40 PF00400.32 EMC76758.1 - 1.2e-40 136.7 8.9 7.6e-08 32.9 0.1 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC76758.1 - 5.5e-18 65.1 0.2 1.2e-05 25.5 0.0 5.5 1 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain LisH_TPL PF17814.1 EMC76758.1 - 1.2e-13 50.4 0.2 2.3e-13 49.5 0.2 1.5 1 0 0 1 1 1 1 LisH-like dimerisation domain Ge1_WD40 PF16529.5 EMC76758.1 - 1.3e-13 50.6 0.6 0.0025 16.8 0.1 3.6 2 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EMC76758.1 - 4.2e-09 35.6 0.3 0.00087 18.1 0.1 3.9 2 1 2 4 4 4 2 Nucleoporin Nup120/160 eIF2A PF08662.11 EMC76758.1 - 0.0015 18.4 1.3 1.2 8.9 0.2 3.6 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Hira PF07569.11 EMC76758.1 - 0.0033 17.2 1.7 1.6 8.4 0.0 4.4 5 0 0 5 5 5 1 TUP1-like enhancer of split PD40 PF07676.12 EMC76758.1 - 0.018 14.9 0.0 0.7 9.9 0.0 3.2 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat LisH PF08513.11 EMC76758.1 - 0.022 14.7 0.0 0.051 13.6 0.0 1.7 1 0 0 1 1 1 0 LisH CSD PF00313.22 EMC76759.1 - 3.2e-10 39.7 0.0 1e-09 38.1 0.0 1.7 1 1 0 1 1 1 1 'Cold-shock' DNA-binding domain Glyco_transf_7N PF13733.6 EMC76760.1 - 4.3e-58 194.7 0.1 5.8e-58 194.3 0.1 1.2 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.14 EMC76760.1 - 1.4e-33 114.4 0.3 2.6e-33 113.5 0.3 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 EMC76760.1 - 0.12 11.8 0.2 0.56 9.6 0.1 1.9 1 1 2 3 3 3 0 Glycosyltransferase like family 2 Kazal_1 PF00050.21 EMC76761.1 - 3e-17 62.4 4.9 1.2e-16 60.4 1.0 2.0 1 1 1 2 2 2 2 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 EMC76761.1 - 1.3e-10 41.2 3.9 1.5e-10 41.0 0.6 2.0 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain zf-RING_11 PF17123.5 EMC76761.1 - 0.14 12.0 0.9 0.14 12.0 0.9 2.0 2 0 0 2 2 2 0 RING-like zinc finger Trypan_PARP PF05887.11 EMC76762.1 - 0.0023 17.9 6.6 0.0038 17.2 6.6 1.4 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) ATG16 PF08614.11 EMC76763.1 - 0.00031 21.0 28.6 0.00031 21.0 28.6 2.7 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) HALZ PF02183.18 EMC76763.1 - 0.01 16.0 1.6 0.01 16.0 1.6 3.8 3 0 0 3 3 3 0 Homeobox associated leucine zipper GAS PF13851.6 EMC76763.1 - 0.48 9.7 56.7 0.32 10.3 20.9 3.6 2 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding DUF3584 PF12128.8 EMC76763.1 - 1.6 6.1 47.8 2.3 5.6 47.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Arm PF00514.23 EMC76763.1 - 6.9 6.9 12.5 0.91 9.7 0.0 4.3 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat DUF948 PF06103.11 EMC76763.1 - 8.6 6.7 11.5 5.1 7.4 5.7 3.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Tropomyosin_1 PF12718.7 EMC76763.1 - 8.9 6.5 55.4 2.8 8.1 28.1 3.8 1 1 1 2 2 2 0 Tropomyosin like IFT57 PF10498.9 EMC76764.1 - 2e-99 333.0 5.4 2.4e-99 332.8 5.4 1.0 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Ribonuc_L-PSP PF01042.21 EMC76764.1 - 0.13 12.3 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Endoribonuclease L-PSP Prominin PF05478.11 EMC76764.1 - 0.89 7.4 5.7 1.1 7.2 5.7 1.1 1 0 0 1 1 1 0 Prominin Fez1 PF06818.15 EMC76764.1 - 2.3 8.6 13.7 0.041 14.3 2.5 2.1 1 1 1 2 2 2 0 Fez1 CD47 PF04549.14 EMC76765.1 - 7.1e-41 139.8 20.5 9.2e-41 139.5 20.5 1.1 1 0 0 1 1 1 1 CD47 transmembrane region V-set_CD47 PF08204.11 EMC76765.1 - 1.8e-34 118.6 0.1 3e-34 117.8 0.1 1.3 1 0 0 1 1 1 1 CD47 immunoglobulin-like domain MaAIMP_sms PF16951.5 EMC76765.1 - 0.0022 17.7 0.5 0.0059 16.3 0.5 1.8 1 1 0 1 1 1 1 Putative methionine and alanine importer, small subunit V-set PF07686.17 EMC76765.1 - 0.011 15.9 0.1 0.018 15.2 0.1 1.2 1 0 0 1 1 1 0 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC76765.1 - 0.023 15.3 0.8 0.061 13.9 0.1 1.9 2 0 0 2 2 2 0 Immunoglobulin domain I-set PF07679.16 EMC76765.1 - 0.035 14.2 0.1 0.077 13.1 0.1 1.5 1 0 0 1 1 1 0 Immunoglobulin I-set domain ig PF00047.25 EMC76765.1 - 0.055 13.6 0.1 0.15 12.2 0.1 1.7 1 1 0 1 1 1 0 Immunoglobulin domain C1-set PF07654.15 EMC76765.1 - 0.084 13.3 1.0 0.31 11.5 1.0 1.9 1 1 0 1 1 1 0 Immunoglobulin C1-set domain DUF5310 PF17237.2 EMC76765.1 - 0.43 10.5 2.8 1.4 8.9 2.8 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5310) XK-related PF09815.9 EMC76766.1 - 2.6e-89 299.6 30.7 3e-89 299.4 30.7 1.0 1 0 0 1 1 1 1 XK-related protein Lactamase_B PF00753.27 EMC76767.1 - 4.4e-20 72.5 0.7 5.3e-20 72.3 0.7 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EMC76767.1 - 0.00098 18.7 0.1 0.0018 17.8 0.1 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain DUF5617 PF18493.1 EMC76767.1 - 0.027 14.6 0.0 0.075 13.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5617) Metallophos_3 PF14582.6 EMC76767.1 - 0.12 11.7 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily TRAM_LAG1_CLN8 PF03798.16 EMC76768.1 - 3.6e-26 92.1 18.8 3.6e-26 92.1 18.8 1.4 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 EMC76768.1 - 2.2e-22 78.5 2.7 2.6e-22 78.2 0.8 2.2 2 0 0 2 2 2 1 TRAM1-like protein DUF3382 PF11862.8 EMC76768.1 - 0.036 14.3 0.1 0.14 12.5 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3382) DUF3671 PF12420.8 EMC76768.1 - 1.7 8.7 11.5 0.17 11.9 4.2 2.8 2 1 1 3 3 3 0 Protein of unknown function DUF4834 PF16118.5 EMC76768.1 - 4.9 8.2 9.2 5.3 8.1 0.3 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) zf-H2C2_2 PF13465.6 EMC76769.1 - 3.9e-22 77.6 50.9 2.6e-09 37.1 0.7 6.7 7 0 0 7 7 7 3 Zinc-finger double domain zf-C2H2 PF00096.26 EMC76769.1 - 4.3e-20 71.0 53.8 3.2e-07 30.4 3.2 6.6 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC76769.1 - 3.4e-18 64.8 51.8 0.00013 22.5 3.1 6.5 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC76769.1 - 1.8e-09 37.6 29.1 0.0035 17.6 0.6 6.3 6 0 0 6 6 6 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMC76769.1 - 1.4e-06 28.1 42.2 0.00023 21.0 3.5 7.0 7 1 0 7 7 6 4 C2H2-type zinc finger zf-C2HC_2 PF13913.6 EMC76769.1 - 2.4e-05 24.1 28.2 0.072 13.0 2.5 6.6 6 0 0 6 6 6 3 zinc-finger of a C2HC-type SET PF00856.28 EMC76769.1 - 6e-05 23.5 0.1 0.003 18.0 0.1 2.4 1 1 0 1 1 1 1 SET domain zf-met PF12874.7 EMC76769.1 - 0.00069 19.9 32.2 0.28 11.6 2.5 6.3 6 0 0 6 6 6 2 Zinc-finger of C2H2 type zf_UBZ PF18439.1 EMC76769.1 - 0.0046 16.5 24.8 0.69 9.6 0.2 5.9 6 0 0 6 6 6 3 Ubiquitin-Binding Zinc Finger zf-C2H2_11 PF16622.5 EMC76769.1 - 0.0068 16.1 2.8 0.0068 16.1 2.8 6.0 7 0 0 7 7 7 2 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 EMC76769.1 - 0.011 16.0 33.1 0.4 11.0 2.2 5.7 1 1 5 6 6 6 0 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 EMC76769.1 - 0.015 15.6 33.6 0.36 11.2 5.4 3.8 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_15 PF17032.5 EMC76769.1 - 0.031 15.0 25.8 0.08 13.7 1.3 3.7 2 1 2 4 4 3 0 zinc-ribbon family YhfH PF14149.6 EMC76769.1 - 0.037 14.0 13.5 5.7 7.0 1.9 4.6 4 0 0 4 4 4 0 YhfH-like protein Zn-ribbon_8 PF09723.10 EMC76769.1 - 0.081 13.0 25.7 0.82 9.8 1.5 4.8 3 2 2 5 5 5 0 Zinc ribbon domain PyrI_C PF02748.15 EMC76769.1 - 0.29 11.1 0.2 0.29 11.1 0.2 5.7 5 1 1 6 6 6 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain PRP21_like_P PF12230.8 EMC76769.1 - 0.43 10.4 3.9 5.7 6.7 0.3 2.3 1 1 1 2 2 2 0 Pre-mRNA splicing factor PRP21 like protein DUF2256 PF10013.9 EMC76769.1 - 0.95 9.6 21.3 12 6.1 0.1 6.2 6 0 0 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2256) HypA PF01155.19 EMC76769.1 - 0.98 9.5 19.8 9.7 6.3 5.2 3.8 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA HNH_5 PF14279.6 EMC76769.1 - 4.1 7.3 20.2 5.4 7.0 0.1 5.4 5 1 0 5 5 5 0 HNH endonuclease zf-AN1 PF01428.16 EMC76769.1 - 6.4 7.0 33.6 3.3 8.0 2.5 6.6 6 0 0 6 6 6 0 AN1-like Zinc finger OATP PF03137.20 EMC76770.1 - 1.2e-183 611.3 16.2 1.5e-183 611.0 16.2 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 EMC76770.1 - 4.9e-27 94.8 24.3 1.3e-26 93.4 15.0 2.9 2 2 0 2 2 2 2 Major Facilitator Superfamily Kazal_2 PF07648.15 EMC76770.1 - 7.7e-10 38.7 9.7 2.4e-09 37.2 9.7 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EMC76770.1 - 0.00016 21.6 9.6 0.0004 20.3 9.6 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain DUF3740 PF12548.8 EMC76771.1 - 1.4e-58 197.6 21.3 1.6e-53 181.1 1.0 2.8 3 0 0 3 3 3 2 Sulfatase protein Sulfatase PF00884.23 EMC76771.1 - 1.4e-48 165.9 0.7 1.4e-48 165.9 0.7 1.8 2 0 0 2 2 2 1 Sulfatase Phosphodiest PF01663.22 EMC76771.1 - 0.042 13.5 1.4 0.82 9.2 0.2 2.8 3 0 0 3 3 3 0 Type I phosphodiesterase / nucleotide pyrophosphatase ILEI PF15711.5 EMC76774.1 - 8e-08 32.7 0.0 1.2e-06 28.8 0.0 2.4 1 1 2 3 3 3 1 Interleukin-like EMT inducer HSF_DNA-bind PF00447.17 EMC76779.1 - 9.6e-27 93.4 1.4 1.3e-26 93.0 1.4 1.2 1 0 0 1 1 1 1 HSF-type DNA-binding TEX33 PF15400.6 EMC76780.1 - 2.3e-36 125.3 0.3 2.4e-36 125.3 0.3 1.0 1 0 0 1 1 1 1 Testis-expressed sequence 33 protein family Rhodanese PF00581.20 EMC76781.1 - 2.5e-27 95.5 0.0 2.8e-12 47.1 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain Rhodanese PF00581.20 EMC76782.1 - 8.1e-32 109.9 0.0 2.7e-18 66.4 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain BTB_2 PF02214.22 EMC76783.1 - 5.4e-23 81.2 0.0 9.7e-23 80.3 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 EMC76783.1 - 0.011 15.9 0.0 0.019 15.2 0.0 1.4 1 0 0 1 1 1 0 BTB/POZ domain SAM_LFY PF01698.16 EMC76783.1 - 0.08 12.9 0.1 0.24 11.4 0.0 1.8 2 0 0 2 2 2 0 Floricaula / Leafy protein SAM domain zf-RING_9 PF13901.6 EMC76783.1 - 0.31 11.0 2.0 3.2 7.7 0.0 2.4 3 0 0 3 3 3 0 Putative zinc-RING and/or ribbon IL2RB_N1 PF18707.1 EMC76784.1 - 3.8e-19 69.0 3.4 8.1e-19 68.0 1.5 2.5 2 1 0 2 2 2 1 Interleukin-2 receptor subunit beta N-terminal domain 1 fn3 PF00041.21 EMC76784.1 - 7.5e-07 29.4 0.7 1.5e-06 28.4 0.7 1.5 1 0 0 1 1 1 1 Fibronectin type III domain DPBB_1 PF03330.18 EMC76784.1 - 0.02 15.2 0.0 0.039 14.2 0.0 1.4 1 0 0 1 1 1 0 Lytic transglycolase Pur_ac_phosph_N PF16656.5 EMC76784.1 - 0.2 12.3 2.4 0.58 10.8 2.4 1.8 1 1 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain C1q PF00386.21 EMC76785.1 - 1e-35 122.7 1.8 1.3e-35 122.4 1.8 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 EMC76785.1 - 1e-08 34.8 15.2 1.5e-08 34.3 15.2 1.1 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) 7tm_1 PF00001.21 EMC76786.1 - 2.9e-62 210.4 19.7 3.7e-62 210.0 19.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC76786.1 - 2.3e-11 43.6 12.8 2.9e-11 43.2 12.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC76786.1 - 3.7e-08 33.3 9.7 5.3e-08 32.8 9.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 EMC76786.1 - 8.7e-06 25.3 5.0 8.7e-06 25.3 5.0 2.0 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srw PF10324.9 EMC76786.1 - 0.00014 21.3 11.3 0.00056 19.3 0.1 2.4 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw Serpentine_r_xa PF03383.15 EMC76786.1 - 0.00066 19.7 1.7 0.00066 19.7 1.7 2.7 2 1 1 3 3 3 1 Caenorhabditis serpentine receptor-like protein, class xa TAS2R PF05296.13 EMC76786.1 - 0.093 11.8 12.3 0.36 9.9 12.3 1.8 1 1 0 1 1 1 0 Taste receptor protein (TAS2R) Rab5ip PF07019.12 EMC76786.1 - 1.2 9.8 5.3 0.31 11.6 0.8 2.4 2 0 0 2 2 2 0 Rab5-interacting protein (Rab5ip) 7tm_4 PF13853.6 EMC76786.1 - 5.8 6.6 15.3 37 3.9 15.3 2.3 1 1 0 1 1 1 0 Olfactory receptor Ras PF00071.22 EMC76787.1 - 3.8e-54 182.7 0.0 4.3e-54 182.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC76787.1 - 2.7e-22 79.2 0.0 3.7e-22 78.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC76787.1 - 2.3e-07 30.5 0.0 3.8e-07 29.7 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family Sec7 PF01369.20 EMC76788.1 - 4.4e-69 231.8 0.0 7.3e-69 231.1 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 EMC76788.1 - 1.5e-26 92.9 0.0 2.4e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EMC76788.1 - 0.00012 22.4 0.1 0.00036 20.9 0.1 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 EMC76788.1 - 0.0055 17.0 0.0 0.51 10.7 0.0 2.4 1 1 1 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 EMC76788.1 - 0.032 14.3 0.0 0.075 13.1 0.0 1.6 1 0 0 1 1 1 0 PH domain Syntaxin-6_N PF09177.11 EMC76788.1 - 0.066 13.8 1.4 15 6.2 0.0 2.4 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Pilosulin PF17499.2 EMC76788.1 - 0.18 12.0 0.0 0.53 10.5 0.0 1.8 2 0 0 2 2 2 0 Ant venom peptides LRR_8 PF13855.6 EMC76789.1 - 2.4e-24 84.8 15.7 6.4e-15 54.7 2.1 3.4 1 1 2 3 3 3 3 Leucine rich repeat LRR_5 PF13306.6 EMC76789.1 - 3e-07 30.5 1.1 8.9e-07 28.9 0.5 2.1 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 EMC76789.1 - 1.1e-06 28.8 12.9 0.007 16.8 0.1 3.8 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) fn3 PF00041.21 EMC76789.1 - 0.011 16.1 0.1 0.028 14.8 0.1 1.7 1 0 0 1 1 1 0 Fibronectin type III domain LRR_9 PF14580.6 EMC76789.1 - 0.027 14.0 1.1 0.12 11.8 0.6 2.0 1 1 1 2 2 2 0 Leucine-rich repeat CD34_antigen PF06365.12 EMC76789.1 - 0.08 12.5 0.1 0.14 11.7 0.1 1.4 1 0 0 1 1 1 0 CD34/Podocalyxin family LRR_1 PF00560.33 EMC76789.1 - 0.99 10.2 6.8 12 6.9 0.4 4.7 5 0 0 5 5 5 0 Leucine Rich Repeat CARD PF00619.21 EMC76790.1 - 4.8e-20 71.4 0.4 2.4e-19 69.2 0.0 2.6 2 0 0 2 2 2 1 Caspase recruitment domain Guanylate_kin PF00625.21 EMC76790.1 - 0.012 15.3 1.8 0.013 15.2 0.0 1.9 2 0 0 2 2 2 0 Guanylate kinase APG6_N PF17675.1 EMC76790.1 - 0.55 10.8 56.0 2.8 8.5 10.5 4.2 1 1 1 3 3 3 0 Apg6 coiled-coil region WD40_alt PF14077.6 EMC76790.1 - 2.1 8.3 11.3 0.16 11.8 0.3 3.9 4 0 0 4 4 4 0 Alternative WD40 repeat motif BORG_CEP PF14957.6 EMC76791.1 - 5.8e-12 46.9 11.6 3.7e-11 44.3 3.7 3.4 3 1 0 3 3 3 1 Cdc42 effector PBD PF00786.28 EMC76791.1 - 1.1e-06 28.9 0.7 3.5e-06 27.3 0.7 1.9 1 0 0 1 1 1 1 P21-Rho-binding domain Gal-bind_lectin PF00337.22 EMC76792.1 - 1.1e-31 109.2 0.1 1.3e-31 108.9 0.1 1.0 1 0 0 1 1 1 1 Galactoside-binding lectin tRNA_anti-codon PF01336.25 EMC76792.1 - 0.072 13.1 0.0 1.7 8.7 0.0 2.1 2 0 0 2 2 2 0 OB-fold nucleic acid binding domain Glyco_hydro_38 PF18438.1 EMC76792.1 - 0.15 12.1 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 C-terminal domain 1 VHS PF00790.19 EMC76793.1 - 1.7e-36 125.2 1.9 8e-36 123.0 0.0 2.3 2 1 1 3 3 3 1 VHS domain Alpha_adaptinC2 PF02883.20 EMC76793.1 - 2e-30 105.3 0.1 4.8e-30 104.1 0.1 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain GAT PF03127.14 EMC76793.1 - 2.5e-23 82.2 4.7 2.5e-23 82.2 4.7 2.7 2 0 0 2 2 2 1 GAT domain GGA_N-GAT PF18308.1 EMC76793.1 - 5.5e-21 73.9 3.7 1.8e-20 72.2 3.7 2.0 1 0 0 1 1 1 1 GGA N-GAT domain Ferritin PF00210.24 EMC76793.1 - 0.0047 16.9 1.4 0.059 13.3 1.1 2.1 2 0 0 2 2 2 1 Ferritin-like domain Elf4 PF07011.11 EMC76793.1 - 0.0081 16.1 4.4 0.23 11.4 1.5 2.4 2 0 0 2 2 2 1 Early Flowering 4 domain DNA_ligase_A_N PF04675.14 EMC76793.1 - 0.033 14.5 2.8 8.5 6.7 0.4 3.2 2 1 1 3 3 3 0 DNA ligase N terminus RsbU_N PF08673.10 EMC76793.1 - 0.13 12.4 0.6 0.67 10.1 0.4 2.3 2 0 0 2 2 2 0 Phosphoserine phosphatase RsbU, N-terminal domain DASH_Dad4 PF08650.10 EMC76793.1 - 0.15 12.1 5.6 0.16 11.9 1.9 2.6 3 0 0 3 3 3 0 DASH complex subunit Dad4 MCPsignal PF00015.21 EMC76793.1 - 0.26 11.1 2.1 0.42 10.4 2.1 1.2 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain PCRF PF03462.18 EMC76793.1 - 0.3 10.9 4.5 0.53 10.1 4.5 1.3 1 0 0 1 1 1 0 PCRF domain DUF3450 PF11932.8 EMC76793.1 - 0.54 9.5 7.3 0.91 8.8 7.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) RhoGAP PF00620.27 EMC76794.1 - 2.3e-43 147.7 0.1 5.3e-43 146.4 0.0 1.6 2 0 0 2 2 2 1 RhoGAP domain BAR PF03114.18 EMC76794.1 - 6.7e-22 78.3 3.1 6.7e-22 78.3 3.1 1.4 2 0 0 2 2 2 1 BAR domain Hydrolase_like PF13242.6 EMC76794.1 - 3.9e-20 71.7 0.0 7.2e-20 70.8 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 EMC76794.1 - 9.1e-08 32.4 0.8 0.00017 21.7 0.0 3.7 4 0 0 4 4 4 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EMC76794.1 - 7.5e-05 23.1 0.0 0.00023 21.5 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Sec5 PF15469.6 EMC76794.1 - 0.0051 16.6 0.4 0.011 15.5 0.4 1.5 1 0 0 1 1 1 1 Exocyst complex component Sec5 PGP_phosphatase PF09419.10 EMC76794.1 - 0.019 14.6 0.0 0.042 13.5 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase Ribosomal_60s PF00428.19 EMC76794.1 - 0.18 12.4 1.2 0.64 10.6 1.2 1.9 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF5470 PF17564.2 EMC76794.1 - 0.23 11.7 0.7 0.79 10.0 0.4 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5470) Gal-bind_lectin PF00337.22 EMC76795.1 - 4.1e-27 94.3 0.0 4.8e-27 94.1 0.0 1.0 1 0 0 1 1 1 1 Galactoside-binding lectin 7tm_1 PF00001.21 EMC76796.1 - 7.1e-32 110.8 7.9 8.4e-32 110.5 7.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC76796.1 - 2.7 7.6 6.6 0.24 11.0 1.7 1.7 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx ArfGap PF01412.18 EMC76797.1 - 1.7e-37 128.1 0.9 2.2e-37 127.7 0.2 1.5 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PH PF00169.29 EMC76797.1 - 5e-23 81.6 0.1 5.2e-12 46.2 0.0 2.3 2 0 0 2 2 2 2 PH domain PH_8 PF15409.6 EMC76797.1 - 2.5e-06 27.7 1.0 0.028 14.7 0.0 2.8 3 1 0 3 3 3 2 Pleckstrin homology domain PH_11 PF15413.6 EMC76797.1 - 3.7e-06 27.3 1.7 0.00077 19.9 1.0 3.4 2 1 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 EMC76797.1 - 4.6e-05 23.5 0.9 0.041 14.0 0.0 3.1 3 1 0 3 3 3 2 PH domain EloA-BP1 PF15870.5 EMC76798.1 - 0.03 14.6 2.0 0.067 13.4 2.0 1.8 1 1 0 1 1 1 0 ElonginA binding-protein 1 Linker_histone PF00538.19 EMC76799.1 - 2.2e-13 50.4 0.3 2.2e-13 50.4 0.3 2.0 3 0 0 3 3 3 1 linker histone H1 and H5 family RR_TM4-6 PF06459.12 EMC76799.1 - 5.4 6.8 8.8 5.9 6.6 8.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Aminotran_1_2 PF00155.21 EMC76800.1 - 5.4e-72 243.0 0.0 6.8e-72 242.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EMC76800.1 - 3.6e-07 29.5 0.0 1.6e-06 27.4 0.0 2.0 2 1 1 3 3 3 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EMC76800.1 - 0.00011 20.9 0.0 0.00016 20.3 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 EMC76800.1 - 0.0041 16.5 0.1 0.013 14.8 0.1 1.8 1 1 1 2 2 2 1 Beta-eliminating lyase ScsC_N PF18312.1 EMC76800.1 - 0.079 12.8 0.1 0.17 11.7 0.1 1.5 1 0 0 1 1 1 0 Copper resistance protein ScsC N-terminal domain OKR_DC_1 PF01276.20 EMC76800.1 - 0.1 11.3 0.0 1.3 7.6 0.0 2.1 1 1 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain 7tm_1 PF00001.21 EMC76801.1 - 2.7e-50 171.2 18.2 3.2e-50 170.9 18.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 EMC76801.1 - 1e-08 34.9 13.8 1.5e-06 27.7 13.8 2.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.6 EMC76801.1 - 6.7e-08 32.6 10.1 1.5e-06 28.2 10.1 2.1 1 1 0 1 1 1 1 Olfactory receptor DUF3585 PF12130.8 EMC76802.1 - 5.9e-47 159.2 14.7 9.4e-47 158.6 14.7 1.3 1 0 0 1 1 1 1 Bivalent Mical/EHBP Rab binding domain LIM PF00412.22 EMC76802.1 - 1.7e-08 34.6 4.1 3.1e-08 33.7 4.1 1.4 1 0 0 1 1 1 1 LIM domain CH PF00307.31 EMC76802.1 - 5.2e-07 29.8 0.0 8.4e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain Roughex PF06020.11 EMC76802.1 - 0.0019 17.4 4.3 0.004 16.3 4.3 1.5 1 0 0 1 1 1 1 Drosophila roughex protein UPF0193 PF05250.11 EMC76803.1 - 3.4e-66 223.2 4.0 3.7e-66 223.0 4.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0193) Sox_N PF12444.8 EMC76804.1 - 1.9e-30 105.8 0.2 1.9e-30 105.8 0.2 3.0 3 0 0 3 3 3 1 Sox developmental protein N terminal HMG_box PF00505.19 EMC76804.1 - 4.9e-25 87.7 1.5 8.5e-25 87.0 1.5 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC76804.1 - 7.6e-10 39.2 0.9 7.6e-10 39.2 0.9 1.8 2 0 0 2 2 2 1 HMG-box domain Arfaptin PF06456.13 EMC76805.1 - 2.3e-84 282.6 2.1 3.7e-84 281.9 2.1 1.3 1 0 0 1 1 1 1 Arfaptin-like domain PDZ PF00595.24 EMC76805.1 - 3.8e-11 43.2 0.2 6.8e-11 42.4 0.2 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC76805.1 - 4.7e-08 32.8 0.1 9e-08 31.9 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC76805.1 - 7.2e-06 26.2 1.0 1.4e-05 25.3 0.1 2.0 3 0 0 3 3 3 1 PDZ domain BAR PF03114.18 EMC76805.1 - 9.9e-06 25.4 1.3 9.1e-05 22.2 1.3 2.2 1 1 0 1 1 1 1 BAR domain BAR_3 PF16746.5 EMC76805.1 - 2.3e-05 24.2 0.9 0.057 13.1 0.1 2.2 2 0 0 2 2 2 2 BAR domain of APPL family GRASP55_65 PF04495.14 EMC76805.1 - 0.028 14.8 0.0 0.63 10.3 0.0 2.3 2 0 0 2 2 2 0 GRASP55/65 PDZ-like domain MFS_1 PF07690.16 EMC76806.1 - 6.2e-38 130.6 32.3 2e-32 112.5 22.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Ank_2 PF12796.7 EMC76807.1 - 1.6e-32 111.9 3.1 3.4e-10 40.4 0.1 4.4 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 EMC76807.1 - 1.7e-29 100.9 7.1 0.00013 22.2 0.1 6.9 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.6 EMC76807.1 - 1.6e-27 95.5 5.9 1.3e-08 35.2 0.0 6.1 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC76807.1 - 6.2e-26 90.1 7.0 5.5e-08 32.9 0.0 6.8 4 3 4 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC76807.1 - 4.1e-24 82.0 6.9 0.00077 19.7 0.1 7.8 9 0 0 9 9 9 5 Ankyrin repeat Patatin PF01734.22 EMC76807.1 - 7e-19 68.8 1.7 4.7e-18 66.1 1.7 2.1 1 1 0 1 1 1 1 Patatin-like phospholipase HI0933_like PF03486.14 EMC76807.1 - 0.21 10.2 0.0 0.35 9.5 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein bZIP_Maf PF03131.17 EMC76808.1 - 1.1e-32 112.4 8.4 1.4e-32 112.0 8.4 1.1 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.21 EMC76808.1 - 0.00031 20.8 12.5 0.0021 18.1 12.5 2.1 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMC76808.1 - 0.0076 16.3 10.2 0.0099 15.9 8.5 2.1 1 1 2 3 3 3 1 Basic region leucine zipper DUF1192 PF06698.11 EMC76808.1 - 0.02 14.9 0.1 0.02 14.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) DivIC PF04977.15 EMC76808.1 - 0.027 14.2 1.1 0.027 14.2 1.1 2.2 1 1 1 2 2 2 0 Septum formation initiator FliD_N PF02465.18 EMC76808.1 - 0.06 14.0 0.6 0.17 12.6 0.2 1.8 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Q_salvage PF10343.9 EMC76808.1 - 0.061 12.9 0.1 0.077 12.6 0.1 1.2 1 0 0 1 1 1 0 Potential Queuosine, Q, salvage protein family Cnn_1N PF07989.11 EMC76808.1 - 0.079 13.1 3.6 0.23 11.6 3.6 1.8 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 Nup54 PF13874.6 EMC76808.1 - 0.093 12.8 4.2 0.13 12.3 4.2 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 YabA PF06156.13 EMC76808.1 - 0.48 11.1 3.9 0.39 11.4 0.4 2.0 1 1 1 2 2 2 0 Initiation control protein YabA Solute_trans_a PF03619.16 EMC76809.1 - 1.2e-93 313.5 21.4 1.4e-93 313.3 21.4 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Pkinase PF00069.25 EMC76810.1 - 5.6e-20 71.8 0.0 7.1e-20 71.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC76810.1 - 1.4e-12 47.5 0.0 1.9e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC76810.1 - 6.3e-10 38.4 0.1 9.8e-10 37.8 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMC76810.1 - 0.00022 21.2 0.1 0.0014 18.6 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EMC76810.1 - 0.049 12.6 0.1 0.072 12.1 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 EMC76810.1 - 0.096 12.0 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family IRK_C PF17655.1 EMC76811.1 - 1.2e-76 256.1 0.0 2e-76 255.5 0.0 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 EMC76811.1 - 9.1e-63 210.3 3.0 1.3e-62 209.8 3.0 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain IRK_N PF08466.10 EMC76811.1 - 0.015 15.5 5.2 0.015 15.5 5.2 1.9 2 0 0 2 2 2 0 Inward rectifier potassium channel N-terminal DUF92 PF01940.16 EMC76811.1 - 0.12 11.8 0.2 0.22 10.9 0.2 1.3 1 0 0 1 1 1 0 Integral membrane protein DUF92 Ion_trans_2 PF07885.16 EMC76811.1 - 0.2 11.7 13.6 0.33 10.9 11.7 2.2 1 1 1 2 2 2 0 Ion channel KASH_CCD PF14662.6 EMC76812.1 - 3.1e-05 23.9 13.7 8.7e-05 22.4 13.7 1.6 1 1 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH Lebercilin PF15619.6 EMC76812.1 - 0.00021 21.0 11.2 0.041 13.6 0.3 2.3 2 0 0 2 2 2 2 Ciliary protein causing Leber congenital amaurosis disease Laminin_II PF06009.12 EMC76812.1 - 0.00026 21.0 6.9 0.012 15.7 4.9 2.8 1 1 2 3 3 3 1 Laminin Domain II Golgin_A5 PF09787.9 EMC76812.1 - 0.0012 18.3 9.6 0.0015 18.0 9.6 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 5 DASH_Dad4 PF08650.10 EMC76812.1 - 0.0021 18.0 5.0 0.0034 17.3 0.5 2.5 2 1 0 2 2 2 1 DASH complex subunit Dad4 BRE1 PF08647.11 EMC76812.1 - 0.0022 18.0 4.7 0.0022 18.0 4.7 2.5 2 1 1 3 3 3 1 BRE1 E3 ubiquitin ligase Perilipin PF03036.16 EMC76812.1 - 0.0041 16.2 4.8 0.0063 15.6 4.8 1.3 1 0 0 1 1 1 1 Perilipin family RILP PF11461.8 EMC76812.1 - 0.0048 17.1 0.4 0.017 15.3 0.4 1.9 1 0 0 1 1 1 1 Rab interacting lysosomal protein Rab5-bind PF09311.11 EMC76812.1 - 0.0057 16.1 4.8 0.0057 16.1 4.8 2.1 1 1 1 2 2 2 1 Rabaptin-like protein Tropomyosin PF00261.20 EMC76812.1 - 0.008 15.6 10.9 0.018 14.4 10.6 1.6 1 1 0 1 1 1 1 Tropomyosin TSC22 PF01166.18 EMC76812.1 - 0.0081 16.4 8.9 0.029 14.7 1.2 3.3 3 1 0 3 3 3 1 TSC-22/dip/bun family bZIP_Maf PF03131.17 EMC76812.1 - 0.018 15.5 9.9 0.14 12.6 3.9 2.2 1 1 1 2 2 2 0 bZIP Maf transcription factor Sortilin-Vps10 PF15902.5 EMC76812.1 - 0.018 13.8 0.2 0.02 13.7 0.2 1.1 1 0 0 1 1 1 0 Sortilin, neurotensin receptor 3, DUF4200 PF13863.6 EMC76812.1 - 0.021 15.2 8.8 0.04 14.3 8.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) USP8_interact PF08941.10 EMC76812.1 - 0.029 14.2 3.1 0.048 13.5 0.3 2.1 2 0 0 2 2 2 0 USP8 interacting Csm1_N PF18504.1 EMC76812.1 - 0.029 14.7 8.2 0.47 10.8 0.4 2.5 2 0 0 2 2 2 0 Csm1 N-terminal domain GAS PF13851.6 EMC76812.1 - 0.15 11.4 12.6 0.46 9.8 12.5 1.7 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF4618 PF15397.6 EMC76812.1 - 0.19 11.1 12.0 0.36 10.2 12.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) YabA PF06156.13 EMC76812.1 - 0.23 12.1 12.3 0.088 13.5 2.9 2.5 1 1 1 2 2 2 0 Initiation control protein YabA KLRAQ PF10205.9 EMC76812.1 - 0.26 11.6 13.0 6.8 7.0 1.8 3.0 2 1 1 3 3 3 0 Predicted coiled-coil domain-containing protein Exonuc_VII_L PF02601.15 EMC76812.1 - 0.27 10.8 5.1 0.3 10.6 5.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4298 PF14131.6 EMC76812.1 - 0.3 11.1 4.2 0.58 10.2 3.8 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4298) JIP_LZII PF16471.5 EMC76812.1 - 0.4 10.9 15.0 0.48 10.6 1.1 3.1 3 1 0 3 3 3 0 JNK-interacting protein leucine zipper II DUF641 PF04859.12 EMC76812.1 - 0.45 10.8 12.4 3.4 8.0 1.1 2.3 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DUF1664 PF07889.12 EMC76812.1 - 0.57 10.2 7.7 7.8 6.6 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 EMC76812.1 - 0.59 10.3 9.7 1 9.5 9.1 1.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DivIC PF04977.15 EMC76812.1 - 1.5 8.6 7.5 3.2 7.6 0.8 3.2 1 1 3 4 4 4 0 Septum formation initiator TMPIT PF07851.13 EMC76812.1 - 4 6.6 9.7 4.2 6.5 2.0 2.0 1 1 1 2 2 2 0 TMPIT-like protein DUF16 PF01519.16 EMC76812.1 - 4.3 7.9 10.3 2 8.9 2.8 2.6 1 1 0 2 2 2 0 Protein of unknown function DUF16 GIT_CC PF16559.5 EMC76812.1 - 7.5 6.5 14.8 1.2 9.1 1.8 3.5 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF5320 PF17253.2 EMC76812.1 - 7.7 7.7 6.1 14 6.8 2.7 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5320) ER_lumen_recept PF00810.18 EMC76813.1 - 5e-43 147.4 10.3 1.3e-42 146.1 10.3 1.7 1 1 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.14 EMC76813.1 - 0.013 15.3 1.3 0.013 15.3 1.3 3.2 3 0 0 3 3 3 0 PQ loop repeat DUF3810 PF12725.7 EMC76813.1 - 3 7.1 13.2 0.21 10.9 2.9 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3810) DEAD PF00270.29 EMC76814.1 - 3.4e-50 170.3 0.0 2e-49 167.8 0.0 2.0 1 1 1 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC76814.1 - 3.4e-31 107.9 0.0 1e-30 106.3 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC76814.1 - 5.5e-05 23.2 0.0 0.0002 21.4 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF5335 PF17269.2 EMC76814.1 - 0.061 13.2 0.2 0.12 12.2 0.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5335) AAA_19 PF13245.6 EMC76814.1 - 0.072 13.4 0.0 7.9 6.8 0.0 2.5 2 1 0 2 2 2 0 AAA domain Ferritin PF00210.24 EMC76814.1 - 0.1 12.5 1.0 0.24 11.3 1.0 1.7 1 1 0 1 1 1 0 Ferritin-like domain Microtub_bind PF13931.6 EMC76814.1 - 0.18 12.2 0.1 0.33 11.3 0.1 1.4 1 0 0 1 1 1 0 Kinesin-associated microtubule-binding Rad51 PF08423.11 EMC76815.1 - 1.2e-110 368.7 0.0 1.6e-110 368.4 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EMC76815.1 - 3.9e-11 42.9 0.0 5.4e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 EMC76815.1 - 2.2e-06 27.2 0.1 4.6e-06 26.2 0.1 1.6 1 1 0 1 1 1 1 KaiC AAA_25 PF13481.6 EMC76815.1 - 9.8e-06 25.3 0.0 1.5e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 EMC76815.1 - 2.4e-05 24.9 1.1 4.7e-05 23.9 0.4 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix domain NRD1_2 PF01995.16 EMC76815.1 - 0.0022 17.3 0.0 0.0044 16.3 0.0 1.4 1 0 0 1 1 1 1 NrpR regulatory domains NRD1 and 2 DnaB_C PF03796.15 EMC76815.1 - 0.032 13.6 0.1 0.13 11.6 0.1 1.8 1 1 1 2 2 2 0 DnaB-like helicase C terminal domain Chibby PF14645.6 EMC76816.1 - 5.1e-49 165.5 0.6 5.8e-49 165.3 0.6 1.0 1 0 0 1 1 1 1 Chibby family Taxilin PF09728.9 EMC76816.1 - 0.00011 21.6 2.5 0.00013 21.2 2.5 1.1 1 0 0 1 1 1 1 Myosin-like coiled-coil protein LapA_dom PF06305.11 EMC76816.1 - 0.2 11.5 0.2 0.2 11.5 0.2 1.6 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain JIP_LZII PF16471.5 EMC76816.1 - 0.21 11.8 8.7 0.29 11.3 8.7 1.2 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II TSC22 PF01166.18 EMC76816.1 - 2.1 8.7 9.2 0.46 10.8 3.7 2.1 1 1 1 2 2 2 0 TSC-22/dip/bun family Tom22 PF04281.13 EMC76817.1 - 0.0031 17.3 0.2 0.0035 17.1 0.2 1.1 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 Josephin PF02099.17 EMC76818.1 - 3.4e-21 76.1 0.0 3.6e-21 75.9 0.0 1.0 1 0 0 1 1 1 1 Josephin KH_1 PF00013.29 EMC76819.1 - 1.2e-55 185.2 13.4 4.4e-19 68.1 0.4 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EMC76819.1 - 1.1e-16 60.4 7.0 9.4e-06 25.4 0.0 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EMC76819.1 - 2.9e-09 36.7 2.2 0.0043 16.9 0.3 3.5 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 EMC76819.1 - 5.4e-07 29.6 6.5 0.089 12.9 0.1 3.4 3 0 0 3 3 3 3 NusA-like KH domain MOEP19 PF16005.5 EMC76819.1 - 9.5e-05 22.3 0.0 0.014 15.4 0.0 3.1 3 0 0 3 3 3 1 KH-like RNA-binding domain DUF370 PF04025.12 EMC76819.1 - 0.011 15.9 1.0 0.41 10.8 0.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF370) Myosin_head PF00063.21 EMC76820.1 - 2.5e-230 766.3 1.6 2.5e-230 766.3 1.6 3.5 4 1 1 5 5 5 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 EMC76820.1 - 9.9e-161 536.9 278.2 1.2e-160 536.6 278.2 1.0 1 0 0 1 1 1 1 Myosin tail Filament PF00038.21 EMC76820.1 - 7e-05 22.5 51.9 7e-05 22.5 51.9 8.4 1 1 4 6 6 6 2 Intermediate filament protein IQ PF00612.27 EMC76820.1 - 0.00095 18.8 1.1 0.0079 15.9 0.4 2.6 2 0 0 2 2 2 1 IQ calmodulin-binding motif Apolipoprotein PF01442.18 EMC76820.1 - 0.0023 17.8 40.7 0.0023 17.8 40.7 7.4 1 1 6 7 7 7 1 Apolipoprotein A1/A4/E domain DUF1664 PF07889.12 EMC76820.1 - 0.0036 17.4 9.6 0.0036 17.4 9.6 14.1 1 1 17 18 18 18 7 Protein of unknown function (DUF1664) Syntaxin-6_N PF09177.11 EMC76820.1 - 0.011 16.3 8.3 0.011 16.3 8.3 14.1 3 3 8 12 12 12 0 Syntaxin 6, N-terminal DUF4465 PF14717.6 EMC76820.1 - 0.17 12.2 0.2 2.1 8.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4465) Macro PF01661.21 EMC76820.1 - 7 6.7 7.2 4.9 7.2 0.0 4.0 4 0 0 4 4 4 0 Macro domain TRAP_beta PF05753.14 EMC76821.1 - 9.9e-33 113.0 0.0 1.1e-32 112.8 0.0 1.0 1 0 0 1 1 1 1 Translocon-associated protein beta (TRAPB) Cpn60_TCP1 PF00118.24 EMC76822.1 - 9e-143 476.4 7.0 2.8e-142 474.8 7.0 1.6 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family GvpK PF05121.12 EMC76822.1 - 0.26 11.3 1.7 0.91 9.6 0.1 2.5 2 0 0 2 2 2 0 Gas vesicle protein K NCU-G1 PF15065.6 EMC76823.1 - 1.5e-104 349.9 0.0 1.7e-104 349.7 0.0 1.0 1 0 0 1 1 1 1 Lysosomal transcription factor, NCU-G1 MAPEG PF01124.18 EMC76824.1 - 0.00075 19.4 8.8 0.0014 18.5 8.8 1.4 1 0 0 1 1 1 1 MAPEG family Nnf1 PF03980.14 EMC76825.1 - 1.3e-20 73.8 0.5 2.1e-20 73.1 0.5 1.3 1 0 0 1 1 1 1 Nnf1 Tuberin PF03542.16 EMC76825.1 - 0.041 13.0 0.0 0.15 11.1 0.0 1.7 1 1 1 2 2 2 0 Tuberin Mito_carr PF00153.27 EMC76826.1 - 5.4e-51 170.5 6.5 3e-16 59.1 0.1 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Sema PF01403.19 EMC76827.1 - 1.4e-134 449.2 0.0 1.7e-134 448.8 0.0 1.1 1 0 0 1 1 1 1 Sema domain PSI PF01437.25 EMC76827.1 - 1.5e-05 25.4 5.0 3.4e-05 24.3 5.0 1.6 1 0 0 1 1 1 1 Plexin repeat PSI_integrin PF17205.3 EMC76827.1 - 0.053 13.3 3.6 0.32 10.8 3.9 2.1 2 0 0 2 2 2 0 Integrin plexin domain CDC27 PF09507.10 EMC76830.1 - 6.7e-111 371.7 24.1 7.5e-111 371.5 24.1 1.0 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 VWC PF00093.18 EMC76831.1 - 1.7e-26 92.2 49.6 9.8e-11 41.8 11.9 3.3 3 0 0 3 3 3 3 von Willebrand factor type C domain DUF3601 PF12208.8 EMC76831.1 - 0.028 14.5 0.1 42 4.4 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3601) Calpain_III PF01067.22 EMC76832.1 - 4.4e-09 36.7 0.0 7.4e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_8 PF13833.6 EMC76832.1 - 0.0002 21.2 0.0 0.00048 19.9 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair Peptidase_C2 PF00648.21 EMC76832.1 - 0.23 10.5 0.0 0.36 9.8 0.0 1.3 1 0 0 1 1 1 0 Calpain family cysteine protease Peptidase_C101 PF16218.5 EMC76833.1 - 6.7e-115 382.9 2.4 8.4e-115 382.6 2.4 1.1 1 0 0 1 1 1 1 Peptidase family C101 RVT_1 PF00078.27 EMC76834.1 - 0.018 14.6 0.1 0.026 14.0 0.1 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Arm PF00514.23 EMC76836.1 - 7.7e-49 162.3 8.5 2.3e-09 37.0 0.1 8.8 9 0 0 9 9 9 7 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EMC76836.1 - 2.3e-08 34.3 0.9 0.0059 17.0 0.0 3.4 2 2 1 3 3 3 3 HEAT repeats HEAT PF02985.22 EMC76836.1 - 8.4e-05 22.5 4.9 0.32 11.4 0.0 5.5 6 0 0 6 6 6 1 HEAT repeat Adaptin_N PF01602.20 EMC76836.1 - 0.0049 15.5 0.0 0.37 9.3 0.0 2.2 2 0 0 2 2 2 2 Adaptin N terminal region Atx10homo_assoc PF09759.9 EMC76836.1 - 0.0096 15.9 1.0 0.51 10.4 0.0 3.4 4 0 0 4 4 4 1 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.6 EMC76836.1 - 0.01 16.3 4.1 27 5.4 0.1 5.0 4 1 1 5 5 5 0 HEAT-like repeat DAP PF15228.6 EMC76837.1 - 5.6e-29 101.2 7.1 6.1e-29 101.1 7.1 1.0 1 0 0 1 1 1 1 Death-associated protein Ank_5 PF13857.6 EMC76838.1 - 9.7e-16 57.6 0.9 8.4e-07 29.2 0.3 4.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC76838.1 - 5.2e-15 55.8 0.3 1.1e-14 54.7 0.3 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC76838.1 - 9.9e-15 54.7 0.8 4.7e-07 30.2 0.0 3.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC76838.1 - 2.5e-07 30.4 0.3 0.12 13.0 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EMC76838.1 - 6.5e-07 29.5 0.4 0.00043 20.6 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat Nucleo_P87 PF07267.11 EMC76840.1 - 5.8 5.6 11.7 7.6 5.3 11.7 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF2373 PF10180.9 EMC76841.1 - 0.083 12.7 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2373) RINGv PF12906.7 EMC76842.1 - 8.7e-15 54.6 8.6 2e-14 53.4 8.6 1.7 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 EMC76842.1 - 1.7 9.0 15.7 0.058 13.7 9.3 2.0 2 0 0 2 2 2 0 Ring finger domain Spt5_N PF11942.8 EMC76842.1 - 5.7 8.0 11.0 12 6.9 11.0 1.4 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal DLH PF01738.18 EMC76843.1 - 1.6e-36 125.9 0.0 1.8e-36 125.7 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 EMC76843.1 - 1e-07 32.0 0.0 1.4e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EMC76843.1 - 9.4e-06 25.2 0.2 0.018 14.5 0.0 2.3 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EMC76843.1 - 1.2e-05 25.1 0.1 0.0061 16.2 0.1 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 EMC76843.1 - 5.1e-05 22.3 0.0 8.1e-05 21.6 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_3 PF07859.13 EMC76843.1 - 5.5e-05 23.1 0.0 0.19 11.6 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Chlorophyllase PF07224.11 EMC76843.1 - 0.0002 20.5 0.0 0.0003 19.9 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase Hydrolase_4 PF12146.8 EMC76843.1 - 0.0019 17.5 0.2 0.71 9.1 0.1 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 FSH1 PF03959.13 EMC76843.1 - 0.0027 17.4 0.2 0.025 14.3 0.2 2.0 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 EMC76843.1 - 0.013 16.1 0.0 0.016 15.8 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_5 PF12695.7 EMC76843.1 - 0.1 12.3 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family DLH PF01738.18 EMC76844.1 - 1.3e-31 109.9 0.0 1.5e-31 109.7 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 EMC76844.1 - 7.5e-06 25.9 0.0 9.5e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EMC76844.1 - 4.9e-05 22.9 0.1 0.00016 21.2 0.0 1.7 1 1 1 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EMC76844.1 - 0.00021 21.0 0.1 0.037 13.7 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 EMC76844.1 - 0.00031 20.6 0.0 0.00056 19.7 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF915 PF06028.11 EMC76844.1 - 0.00075 18.9 0.0 0.0012 18.2 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_3 PF07859.13 EMC76844.1 - 0.01 15.7 0.0 0.019 14.8 0.0 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold LIDHydrolase PF10230.9 EMC76844.1 - 0.061 12.9 0.0 0.089 12.3 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase DUF1935 PF09149.10 EMC76844.1 - 0.066 13.6 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1935) PhosphMutase PF10143.9 EMC76844.1 - 0.1 12.5 0.0 1.9 8.4 0.0 2.0 1 1 1 2 2 2 0 2,3-bisphosphoglycerate-independent phosphoglycerate mutase BAAT_C PF08840.11 EMC76844.1 - 0.16 11.9 0.1 1.4 8.8 0.1 2.0 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Hydrolase_4 PF12146.8 EMC76844.1 - 0.19 11.0 0.0 12 5.1 0.0 2.1 1 1 1 2 2 2 0 Serine aminopeptidase, S33 DLH PF01738.18 EMC76846.1 - 8.6e-42 143.1 0.0 9.7e-42 143.0 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 EMC76846.1 - 3.4e-07 30.3 0.0 4.8e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EMC76846.1 - 9.7e-06 25.2 0.2 0.00012 21.6 0.0 2.1 1 1 1 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EMC76846.1 - 7.7e-05 22.4 0.0 0.005 16.5 0.0 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMC76846.1 - 0.0047 16.2 0.0 0.29 10.4 0.0 2.3 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EMC76846.1 - 0.066 13.1 0.1 0.24 11.2 0.0 1.8 1 1 1 2 2 2 0 alpha/beta hydrolase fold DUF1935 PF09149.10 EMC76846.1 - 0.13 12.6 0.0 0.25 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1935) Pkinase PF00069.25 EMC76847.1 - 1.9e-44 152.0 0.0 2.2e-44 151.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC76847.1 - 7.9e-22 77.8 0.0 9.1e-22 77.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC76847.1 - 4.5e-05 22.9 0.0 0.00012 21.6 0.0 1.6 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 EMC76847.1 - 0.022 14.4 0.0 0.95 9.0 0.0 2.1 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Cpn60_TCP1 PF00118.24 EMC76848.1 - 9.3e-161 535.8 4.0 1.1e-160 535.5 4.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Methyltransf_23 PF13489.6 EMC76849.1 - 4.1e-05 23.5 0.0 5.1e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC76849.1 - 0.0021 18.7 0.0 0.0032 18.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.13 EMC76849.1 - 0.0085 16.4 0.0 0.014 15.8 0.0 1.3 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_31 PF13847.6 EMC76849.1 - 0.013 15.3 0.0 0.018 14.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 EMC76849.1 - 0.023 14.1 0.0 0.028 13.8 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Met_10 PF02475.16 EMC76849.1 - 0.042 13.6 0.0 0.053 13.3 0.0 1.1 1 0 0 1 1 1 0 Met-10+ like-protein MTS PF05175.14 EMC76849.1 - 0.044 13.3 0.0 0.055 13.0 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase small domain N6_N4_Mtase PF01555.18 EMC76849.1 - 0.051 13.3 0.0 0.072 12.8 0.0 1.2 1 0 0 1 1 1 0 DNA methylase Methyltransf_18 PF12847.7 EMC76849.1 - 0.055 13.4 0.0 0.17 11.8 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain N2227 PF07942.12 EMC76849.1 - 0.12 11.5 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 N2227-like protein Methyltransf_11 PF08241.12 EMC76849.1 - 0.13 13.0 0.0 0.2 12.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 EMC76849.1 - 0.15 11.4 0.0 0.17 11.1 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase 7tm_4 PF13853.6 EMC76850.1 - 8.8e-26 91.3 3.5 1e-25 91.0 3.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC76850.1 - 1.5e-05 24.5 5.3 2e-05 24.1 5.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4519 PF15012.6 EMC76850.1 - 0.7 10.1 0.0 0.7 10.1 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4519) MARVEL PF01284.23 EMC76850.1 - 2.9 7.9 8.5 5.9 6.9 0.5 2.3 1 1 0 2 2 2 0 Membrane-associating domain bZIP_1 PF00170.21 EMC76851.1 - 6.2e-06 26.2 17.3 1.2e-05 25.4 17.3 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMC76851.1 - 9.6e-06 25.6 19.0 1.9e-05 24.7 19.0 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EMC76851.1 - 0.00094 19.7 13.3 0.0015 19.0 13.3 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor DUF3535 PF12054.8 EMC76851.1 - 0.05 12.8 0.3 0.067 12.4 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3535) UPF0242 PF06785.11 EMC76851.1 - 0.28 11.2 5.4 0.4 10.8 5.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Macoilin PF09726.9 EMC76851.1 - 0.85 8.1 13.4 1.3 7.5 13.4 1.2 1 0 0 1 1 1 0 Macoilin family DivIC PF04977.15 EMC76851.1 - 1.2 9.0 7.9 0.99 9.2 6.5 1.6 1 1 0 1 1 1 0 Septum formation initiator FapA PF03961.13 EMC76851.1 - 1.9 7.0 3.1 2.4 6.7 3.1 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A FadA PF09403.10 EMC76851.1 - 5.8 7.5 11.2 0.55 10.7 6.0 1.8 1 1 1 2 2 2 0 Adhesion protein FadA HMG14_17 PF01101.18 EMC76852.1 - 6e-12 46.4 37.1 1.3e-11 45.3 37.1 1.5 1 1 0 1 1 1 1 HMG14 and HMG17 Pap_E4 PF02711.14 EMC76852.1 - 5.7 8.0 11.3 16 6.5 11.3 1.7 1 1 0 1 1 1 0 E4 protein SH3BGR PF04908.15 EMC76853.1 - 3.8e-36 123.2 0.1 4.5e-36 123.0 0.1 1.1 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 EMC76853.1 - 0.00036 20.7 0.0 0.00056 20.1 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin DUF4569 PF15133.6 EMC76854.1 - 4.1e-101 338.6 0.2 4.7e-101 338.5 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4569) Na_H_Exchanger PF00999.21 EMC76855.1 - 8.4e-85 284.9 35.7 9.8e-85 284.6 35.7 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family NEXCaM_BD PF16644.5 EMC76855.1 - 2.6e-11 43.8 0.1 3.8e-11 43.3 0.1 1.3 1 0 0 1 1 1 1 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin Claudin_2 PF13903.6 EMC76856.1 - 8.4e-28 97.4 4.2 1.2e-27 96.9 4.2 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 EMC76856.1 - 0.0057 16.5 9.6 0.084 12.7 5.8 2.7 2 1 0 2 2 2 2 PMP-22/EMP/MP20/Claudin family TMEM61 PF15105.6 EMC76856.1 - 3.9 7.2 5.7 0.5 10.2 0.4 1.9 1 1 1 2 2 2 0 TMEM61 protein family Pkinase PF00069.25 EMC76857.1 - 1.8e-145 483.2 0.0 9.9e-73 244.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMC76857.1 - 1.1e-75 254.2 0.0 7.4e-40 136.9 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EMC76857.1 - 7.3e-13 48.5 0.0 3.7e-07 29.7 0.0 3.2 3 1 0 3 3 3 2 Kinase-like Kdo PF06293.14 EMC76857.1 - 6e-11 42.1 0.0 4.2e-06 26.2 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMC76857.1 - 3.3e-08 32.8 0.0 0.001 18.0 0.0 2.2 2 0 0 2 2 2 2 Fungal protein kinase Haspin_kinase PF12330.8 EMC76857.1 - 2.5e-07 30.0 0.2 0.0027 16.7 0.0 2.3 2 0 0 2 2 2 2 Haspin like kinase domain Pkinase_C PF00433.24 EMC76857.1 - 3.5e-06 27.6 1.5 1e-05 26.2 1.5 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.23 EMC76857.1 - 1.5e-05 25.0 0.1 0.25 11.2 0.0 3.0 2 1 1 3 3 3 2 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 EMC76857.1 - 0.00025 20.6 0.0 0.092 12.3 0.0 2.5 2 0 0 2 2 2 2 PhoP regulatory network protein YrbL FTA2 PF13095.6 EMC76857.1 - 0.00061 19.5 0.1 2.2 7.8 0.0 3.2 3 0 0 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EMC76857.1 - 0.016 14.8 0.0 0.61 9.7 0.0 2.3 2 0 0 2 2 2 0 RIO1 family Pox_ser-thr_kin PF05445.11 EMC76857.1 - 0.14 11.1 0.1 1.9 7.3 0.0 2.1 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase Choline_kinase PF01633.20 EMC76857.1 - 0.2 11.2 0.1 6.8 6.2 0.0 2.2 2 0 0 2 2 2 0 Choline/ethanolamine kinase Homeodomain PF00046.29 EMC76859.1 - 1.7e-11 43.7 2.2 5e-05 23.1 0.0 2.7 2 0 0 2 2 2 2 Homeodomain UDPG_MGDP_dh PF00984.19 EMC76859.1 - 0.0034 17.6 0.0 2.3 8.5 0.0 3.3 3 0 0 3 3 3 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain THEG4 PF15834.5 EMC76859.1 - 0.029 14.4 4.1 2.7 8.0 0.4 2.6 2 0 0 2 2 2 0 Testis highly expressed protein 4 DUF1170 PF06663.13 EMC76860.1 - 1e-57 195.3 3.0 5.8e-57 192.8 3.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1170) CRIC_ras_sig PF10534.9 EMC76860.1 - 6.8e-38 128.7 1.1 1.9e-37 127.3 0.2 2.3 2 0 0 2 2 2 1 Connector enhancer of kinase suppressor of ras SAM_1 PF00536.30 EMC76860.1 - 4e-20 72.0 0.5 1.1e-19 70.6 0.5 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH PF00169.29 EMC76860.1 - 6e-15 55.7 2.9 1.5e-14 54.4 2.9 1.7 1 0 0 1 1 1 1 PH domain SAM_2 PF07647.17 EMC76860.1 - 1.3e-13 50.8 0.5 3.7e-13 49.4 0.5 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDZ PF00595.24 EMC76860.1 - 1.1e-09 38.6 0.0 1.3e-08 35.0 0.0 2.6 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 EMC76860.1 - 8e-09 35.2 0.0 4.9e-08 32.7 0.1 2.2 2 0 0 2 2 2 1 PDZ domain SAM_PNT PF02198.16 EMC76860.1 - 0.002 18.0 0.1 0.0048 16.8 0.1 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain PDZ_2 PF13180.6 EMC76860.1 - 0.0038 17.5 0.0 0.013 15.8 0.0 1.9 1 0 0 1 1 1 1 PDZ domain PH_11 PF15413.6 EMC76860.1 - 0.072 13.5 10.8 0.66 10.4 10.8 2.5 1 1 0 1 1 1 0 Pleckstrin homology domain PH_9 PF15410.6 EMC76860.1 - 0.099 13.0 1.9 3 8.2 1.1 2.7 2 1 0 2 2 2 0 Pleckstrin homology domain Phage-MuB_C PF09077.11 EMC76860.1 - 0.12 12.2 0.0 0.33 10.8 0.0 1.7 1 0 0 1 1 1 0 Mu B transposition protein, C terminal Syntaxin PF00804.25 EMC76861.1 - 2e-27 96.2 3.3 3e-27 95.6 3.3 1.2 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.19 EMC76861.1 - 5.9e-08 32.6 2.0 5.9e-08 32.6 2.0 2.4 2 0 0 2 2 2 1 SNARE domain Golgin_A5 PF09787.9 EMC76861.1 - 0.0019 17.8 7.2 0.0019 17.8 7.2 1.7 2 0 0 2 2 2 1 Golgin subfamily A member 5 Syntaxin_2 PF14523.6 EMC76861.1 - 0.026 14.9 4.8 0.1 13.0 0.7 2.2 2 0 0 2 2 2 0 Syntaxin-like protein Lectin_N PF03954.14 EMC76861.1 - 0.15 11.8 2.3 0.22 11.3 0.1 2.2 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain Uds1 PF15456.6 EMC76861.1 - 0.38 10.9 6.4 0.14 12.3 2.8 2.0 2 0 0 2 2 2 0 Up-regulated During Septation DUF16 PF01519.16 EMC76861.1 - 1 9.9 5.1 0.32 11.5 0.4 2.2 2 1 0 2 2 2 0 Protein of unknown function DUF16 Spc7 PF08317.11 EMC76861.1 - 2 7.2 8.1 3.4 6.5 2.8 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF1192 PF06698.11 EMC76861.1 - 4.8 7.3 6.1 15 5.7 1.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) Syntaxin PF00804.25 EMC76862.1 - 4.6e-38 130.9 8.5 5.7e-17 62.0 1.1 3.2 3 0 0 3 3 3 3 Syntaxin SNARE PF05739.19 EMC76862.1 - 1e-18 67.0 2.0 3.7e-18 65.3 1.4 2.1 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.6 EMC76862.1 - 2.3e-09 37.5 0.0 2.3e-08 34.3 0.0 2.3 2 1 0 2 2 2 1 Syntaxin-like protein PYC_OADA PF02436.18 EMC76862.1 - 0.013 15.2 0.4 0.068 12.9 0.0 2.3 3 1 1 4 4 4 0 Conserved carboxylase domain Lzipper-MIP1 PF14389.6 EMC76862.1 - 0.069 13.4 1.6 0.21 11.9 0.0 2.3 2 1 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Lge1 PF11488.8 EMC76862.1 - 0.19 11.9 0.3 0.19 11.9 0.3 2.3 3 0 0 3 3 2 0 Transcriptional regulatory protein LGE1 EcoEI_R_C PF08463.10 EMC76862.1 - 0.21 11.7 1.4 1.2 9.3 0.0 2.5 3 1 0 3 3 3 0 EcoEI R protein C-terminal MCM_N PF14551.6 EMC76862.1 - 0.35 11.5 2.5 1.4 9.5 0.3 2.3 2 0 0 2 2 2 0 MCM N-terminal domain DUF848 PF05852.11 EMC76862.1 - 0.45 10.6 5.2 1.4 9.0 0.2 2.7 2 1 1 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) TolA_bind_tri PF16331.5 EMC76862.1 - 0.56 10.3 3.0 1.5 8.9 0.0 3.0 4 1 0 4 4 4 0 TolA binding protein trimerisation PCRF PF03462.18 EMC76862.1 - 1 9.2 4.4 9 6.1 0.2 2.2 2 0 0 2 2 2 0 PCRF domain YtxH PF12732.7 EMC76862.1 - 1.3 9.6 6.9 1.7 9.3 1.7 2.8 2 1 0 2 2 2 0 YtxH-like protein COG5 PF10392.9 EMC76862.1 - 1.5 9.0 5.6 3.8 7.7 0.7 2.6 2 1 0 2 2 2 0 Golgi transport complex subunit 5 FAM167 PF11652.8 EMC76862.1 - 2 9.0 6.6 3.9 8.0 0.2 2.9 3 1 0 3 3 3 0 FAM167 Fez1 PF06818.15 EMC76862.1 - 2.8 8.3 8.7 1.5 9.3 1.5 2.4 2 1 0 2 2 2 0 Fez1 BRE1 PF08647.11 EMC76862.1 - 2.9 8.0 10.6 4.6 7.4 0.7 3.5 4 1 0 4 4 4 0 BRE1 E3 ubiquitin ligase AAA_13 PF13166.6 EMC76862.1 - 3.7 6.1 8.4 28 3.1 8.4 2.0 1 1 0 1 1 1 0 AAA domain DUF1910 PF08928.10 EMC76862.1 - 6.6 6.8 6.8 0.66 10.0 0.5 2.4 3 1 0 3 3 3 0 Domain of unknown function (DUF1910) zf-C2H2 PF00096.26 EMC76863.1 - 7.3e-12 45.1 8.6 9e-07 29.0 0.8 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC76863.1 - 2.2e-10 40.4 10.1 9.5e-06 25.8 0.8 3.1 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC76863.1 - 3e-08 33.8 8.3 0.00026 21.5 0.9 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 EMC76863.1 - 0.00012 22.3 7.4 0.0021 18.4 0.6 2.1 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf_UBZ PF18439.1 EMC76863.1 - 0.00013 21.5 2.8 0.15 11.7 0.5 2.5 1 1 2 3 3 3 2 Ubiquitin-Binding Zinc Finger ADK_lid PF05191.14 EMC76863.1 - 0.00015 21.6 0.7 0.00015 21.6 0.7 1.6 2 0 0 2 2 2 1 Adenylate kinase, active site lid zf-C2H2_6 PF13912.6 EMC76863.1 - 0.00051 20.0 12.9 0.052 13.6 3.2 2.7 2 2 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC76863.1 - 0.002 18.4 1.2 0.26 11.6 0.0 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.11 EMC76863.1 - 0.0037 17.1 4.4 0.17 11.8 0.5 2.3 2 0 0 2 2 2 2 LYAR-type C2HC zinc finger zf-AN1 PF01428.16 EMC76863.1 - 0.004 17.3 3.9 0.025 14.7 0.3 2.2 2 0 0 2 2 2 1 AN1-like Zinc finger Zn-ribbon_8 PF09723.10 EMC76863.1 - 0.0044 17.1 3.6 0.64 10.2 0.1 2.3 1 1 1 2 2 2 2 Zinc ribbon domain XPA_N PF01286.18 EMC76863.1 - 0.0098 15.9 3.1 0.89 9.6 0.5 2.4 2 1 0 2 2 2 1 XPA protein N-terminal YhfH PF14149.6 EMC76863.1 - 0.019 14.9 0.5 6.5 6.8 0.0 2.2 2 0 0 2 2 2 0 YhfH-like protein zf_C2H2_ZHX PF18387.1 EMC76863.1 - 0.027 14.1 4.5 0.37 10.5 0.7 2.1 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-trcl PF13451.6 EMC76863.1 - 0.037 13.9 1.4 2.4 8.1 0.1 2.3 2 0 0 2 2 2 0 Probable zinc-ribbon domain LIM PF00412.22 EMC76863.1 - 0.042 14.1 2.9 0.63 10.3 2.9 2.2 1 1 0 1 1 1 0 LIM domain Ta0938 PF11494.8 EMC76863.1 - 0.054 13.8 0.0 0.059 13.6 0.0 1.1 1 0 0 1 1 1 0 Ta0938 PknG_rubred PF16919.5 EMC76863.1 - 0.088 13.0 1.6 0.1 12.8 1.6 1.2 1 0 0 1 1 1 0 Protein kinase G rubredoxin domain C1_1 PF00130.22 EMC76863.1 - 0.1 12.5 5.8 1.9 8.4 0.6 2.3 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF2256 PF10013.9 EMC76863.1 - 0.12 12.5 2.0 2.5 8.3 0.1 2.3 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) Cript PF10235.9 EMC76863.1 - 0.15 12.7 3.4 3.6 8.2 3.5 2.2 1 1 0 1 1 1 0 Microtubule-associated protein CRIPT DZR PF12773.7 EMC76863.1 - 0.18 11.8 4.1 1.2 9.2 4.1 2.0 1 1 0 1 1 1 0 Double zinc ribbon zf-C2HC_2 PF13913.6 EMC76863.1 - 0.26 11.2 3.9 3 7.9 0.1 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Zn_ribbon_recom PF13408.6 EMC76863.1 - 0.28 11.7 3.3 7.7 7.1 0.5 2.2 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain DNA_RNApol_7kD PF03604.13 EMC76863.1 - 0.31 10.8 4.3 6.3 6.6 4.4 2.3 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit zf-C2HE PF16278.5 EMC76863.1 - 0.94 10.0 4.2 6.2 7.4 0.6 2.5 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_11 PF16622.5 EMC76863.1 - 3.5 7.5 12.4 2.1 8.2 4.6 2.1 2 0 0 2 2 2 0 zinc-finger C2H2-type Rubredoxin_2 PF18073.1 EMC76863.1 - 5.4 6.8 8.4 6.9 6.5 0.4 2.6 3 0 0 3 3 2 0 Rubredoxin metal binding domain Ribosomal_L31 PF01197.18 EMC76865.1 - 0.02 15.1 9.0 20 5.5 0.1 5.2 2 2 2 4 4 4 0 Ribosomal protein L31 Neisseria_TspB PF05616.13 EMC76865.1 - 0.33 9.4 2.7 0.29 9.6 0.6 1.7 1 1 0 2 2 2 0 Neisseria meningitidis TspB protein Amidohydro_1 PF01979.20 EMC76866.1 - 6.7e-11 42.1 0.0 7.6e-11 41.9 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EMC76866.1 - 4.7e-07 29.6 0.0 5.6e-07 29.4 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family EB1 PF03271.17 EMC76867.1 - 3e-18 65.8 0.4 7.5e-18 64.5 0.2 1.8 2 0 0 2 2 2 1 EB1-like C-terminal motif CH PF00307.31 EMC76867.1 - 6.3e-06 26.3 0.0 1.1e-05 25.6 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain BBP1_C PF15272.6 EMC76867.1 - 0.068 13.0 0.2 0.097 12.5 0.2 1.3 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal CPSase_sm_chain PF00988.22 EMC76868.1 - 1.1e-19 70.6 0.1 1.2e-19 70.5 0.1 1.0 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain UPRTase PF14681.6 EMC76870.1 - 6.9e-64 215.1 0.0 1.4e-63 214.1 0.0 1.5 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRK PF00485.18 EMC76870.1 - 1.9e-29 102.8 0.5 2.8e-29 102.3 0.5 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family Cation_efflux PF01545.21 EMC76871.1 - 9.3e-32 110.4 1.8 1.2e-31 110.0 1.8 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EMC76871.1 - 0.059 13.5 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Dimerisation domain of Zinc Transporter WD40 PF00400.32 EMC76872.1 - 1.2e-07 32.2 4.0 0.0017 19.1 0.1 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat ST7 PF04184.12 EMC76873.1 - 0 1013.1 0.7 0 1012.9 0.7 1.0 1 0 0 1 1 1 1 ST7 protein TPR_6 PF13174.6 EMC76873.1 - 0.00038 20.9 0.0 0.0021 18.6 0.0 2.3 1 0 0 1 1 1 1 Tetratricopeptide repeat Clathrin PF00637.20 EMC76873.1 - 0.047 13.6 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 Region in Clathrin and VPS TPR_19 PF14559.6 EMC76873.1 - 0.11 13.0 4.7 0.3 11.6 0.2 3.4 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EMC76873.1 - 0.13 12.4 5.6 3.4 8.0 0.0 4.5 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 EMC76873.1 - 0.14 12.0 2.8 23 5.0 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat F-actin_cap_A PF01267.17 EMC76875.1 - 7.7e-103 343.6 1.8 8.6e-103 343.4 1.8 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit DUF5121 PF17165.4 EMC76875.1 - 0.046 14.2 0.2 0.11 12.9 0.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF5121) Pkinase_Tyr PF07714.17 EMC76876.1 - 4.7e-94 314.5 0.0 6.9e-94 313.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Sema PF01403.19 EMC76876.1 - 3.1e-52 177.9 4.4 4.7e-52 177.2 4.4 1.2 1 0 0 1 1 1 1 Sema domain Pkinase PF00069.25 EMC76876.1 - 1.5e-39 135.9 0.0 3e-39 135.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain TIG PF01833.24 EMC76876.1 - 2.2e-33 114.2 10.5 1.5e-13 50.6 0.1 4.9 4 0 0 4 4 4 4 IPT/TIG domain Kinase-like PF14531.6 EMC76876.1 - 7.8e-05 22.1 0.1 0.00029 20.2 0.0 1.8 2 0 0 2 2 2 1 Kinase-like PSI PF01437.25 EMC76876.1 - 0.00013 22.5 14.9 0.00013 22.5 14.9 2.4 2 0 0 2 2 2 1 Plexin repeat Pkinase_fungal PF17667.1 EMC76876.1 - 0.0054 15.6 0.0 0.0082 15.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Adeno_E3_CR2 PF02439.15 EMC76876.1 - 0.0067 16.2 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 YajC PF02699.15 EMC76876.1 - 0.13 12.2 0.3 0.32 10.9 0.3 1.6 1 0 0 1 1 1 0 Preprotein translocase subunit Syndecan PF01034.20 EMC76876.1 - 0.16 11.9 0.2 0.42 10.6 0.2 1.7 1 0 0 1 1 1 0 Syndecan domain Caveolin PF01146.17 EMC76877.1 - 2e-60 202.5 2.0 2.3e-60 202.3 2.0 1.0 1 0 0 1 1 1 1 Caveolin Caveolin PF01146.17 EMC76878.1 - 4.5e-49 165.8 6.9 4.9e-49 165.7 6.9 1.0 1 0 0 1 1 1 1 Caveolin PET PF06297.14 EMC76879.1 - 2e-41 140.2 3.2 3.5e-41 139.4 3.2 1.4 1 0 0 1 1 1 1 PET Domain LIM PF00412.22 EMC76879.1 - 5.5e-24 84.2 25.8 1.4e-13 50.8 10.3 4.2 3 2 1 4 4 4 2 LIM domain SHIRT PF18655.1 EMC76879.1 - 0.075 13.6 0.9 0.71 10.5 0.1 2.4 2 0 0 2 2 2 0 SHIRT domain RVT_1 PF00078.27 EMC76880.1 - 0.033 13.7 0.0 0.07 12.6 0.0 1.6 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3371 PF11851.8 EMC76881.1 - 8.8e-34 117.4 3.9 8.8e-34 117.4 3.9 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3371) HLH PF00010.26 EMC76881.1 - 1.4e-15 57.0 0.3 3e-15 55.9 0.3 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain MITF_TFEB_C_3_N PF15951.5 EMC76881.1 - 4.2e-13 50.2 1.4 4.2e-13 50.2 1.4 2.4 2 1 0 2 2 2 1 MITF/TFEB/TFEC/TFE3 N-terminus PGBA_C PF15437.6 EMC76881.1 - 8.7 6.8 10.3 20 5.6 1.9 2.7 2 0 0 2 2 2 0 Plasminogen-binding protein pgbA C-terminal MDFI PF15316.6 EMC76882.1 - 9.8e-73 243.8 36.6 1.1e-72 243.7 36.6 1.0 1 0 0 1 1 1 1 MyoD family inhibitor Forkhead PF00250.18 EMC76883.1 - 4.3e-36 123.0 0.0 5e-36 122.8 0.0 1.0 1 0 0 1 1 1 1 Forkhead domain Linker_histone PF00538.19 EMC76883.1 - 0.041 14.2 0.0 0.061 13.7 0.0 1.3 1 0 0 1 1 1 0 linker histone H1 and H5 family CBM_21 PF03370.13 EMC76884.1 - 1.1e-29 102.9 0.1 2.8e-29 101.6 0.1 1.7 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 EMC76884.1 - 4.6e-08 33.5 0.1 1.8e-07 31.7 0.1 2.0 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) 7tm_1 PF00001.21 EMC76885.1 - 1.3e-33 116.5 10.0 1.7e-33 116.1 10.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC76885.1 - 0.00045 20.1 9.3 0.00072 19.4 9.3 1.3 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC76885.1 - 0.0015 18.3 16.1 0.0024 17.5 16.1 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Arteri_Gl PF00951.18 EMC76885.1 - 1.5 8.6 10.2 5 6.9 6.1 2.5 2 0 0 2 2 2 0 Arterivirus GL envelope glycoprotein Bmt2 PF11968.8 EMC76886.1 - 5.4e-08 33.0 0.3 3.2e-05 23.9 0.3 2.1 1 1 1 2 2 2 2 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 RdRP_1 PF00680.20 EMC76886.1 - 0.14 10.7 0.0 0.21 10.1 0.0 1.3 1 0 0 1 1 1 0 RNA dependent RNA polymerase Tweety PF04906.13 EMC76887.1 - 0.0085 14.8 2.3 0.022 13.5 2.3 1.6 1 0 0 1 1 1 1 Tweety COX7a PF02238.15 EMC76887.1 - 5.6 7.5 5.3 13 6.3 0.4 2.8 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VII DUF4577 PF15145.6 EMC76888.1 - 5.8e-47 158.9 1.4 6.6e-47 158.7 1.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4577) Tetraspanin PF00335.20 EMC76888.1 - 0.019 14.7 0.5 0.026 14.2 0.5 1.1 1 0 0 1 1 1 0 Tetraspanin family MscL PF01741.18 EMC76888.1 - 0.02 15.2 0.1 0.024 14.9 0.1 1.2 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL SieB PF14163.6 EMC76888.1 - 0.035 13.6 0.9 0.052 13.0 0.9 1.2 1 0 0 1 1 1 0 Super-infection exclusion protein B TMIE PF16038.5 EMC76888.1 - 0.093 12.6 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 TMIE protein IFRD PF05004.13 EMC76889.1 - 1e-110 369.6 4.8 1.3e-110 369.4 4.8 1.1 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) IFRD_C PF04836.12 EMC76889.1 - 3.3e-24 85.2 0.7 3.3e-24 85.2 0.7 2.1 2 0 0 2 2 2 1 Interferon-related protein conserved region HEAT PF02985.22 EMC76889.1 - 0.025 14.8 0.5 18 5.9 0.1 3.1 3 0 0 3 3 3 0 HEAT repeat zf-C2H2_2 PF12756.7 EMC76890.1 - 2.3e-43 146.7 24.3 1.7e-23 82.8 6.2 3.3 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EMC76890.1 - 8.7e-10 38.6 20.8 0.0013 19.4 0.4 5.7 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC76890.1 - 8.5e-05 22.7 2.4 8.5e-05 22.7 2.4 3.9 4 0 0 4 4 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EMC76890.1 - 0.00032 21.0 24.5 0.00051 20.3 1.6 5.5 5 1 0 5 5 5 2 Zinc finger, C2H2 type zf-BED PF02892.15 EMC76890.1 - 0.0095 15.9 0.2 0.0095 15.9 0.2 4.9 5 0 0 5 5 5 2 BED zinc finger zf-C2H2_3rep PF18868.1 EMC76890.1 - 0.011 16.4 11.0 21 5.8 0.0 4.9 3 1 1 4 4 4 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_11 PF16622.5 EMC76890.1 - 0.035 13.9 11.0 1 9.2 0.2 3.8 3 0 0 3 3 3 0 zinc-finger C2H2-type YokU PF14122.6 EMC76890.1 - 0.057 13.4 0.0 0.057 13.4 0.0 2.8 4 0 0 4 4 4 0 YokU-like protein, putative antitoxin zf-DBF PF07535.12 EMC76890.1 - 0.21 11.7 8.4 1.3 9.2 0.4 2.9 2 0 0 2 2 2 0 DBF zinc finger DUF1815 PF08844.10 EMC76890.1 - 0.33 11.0 1.9 3.8 7.5 0.0 3.1 3 1 1 4 4 4 0 Domain of unknown function (DUF1815) PyrI_C PF02748.15 EMC76890.1 - 2.6 8.0 15.7 0.19 11.7 0.5 4.5 4 0 0 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DHR-2 PF06920.13 EMC76891.1 - 3.6e-111 372.4 6.8 2.3e-110 369.8 6.8 2.1 1 1 0 1 1 1 1 Dock homology region 2 DOCK_N PF16172.5 EMC76891.1 - 1.5e-101 340.1 0.0 2.9e-101 339.1 0.0 1.5 1 0 0 1 1 1 1 DOCK N-terminus DOCK-C2 PF14429.6 EMC76891.1 - 8e-54 182.4 0.0 1.8e-52 178.0 0.0 2.7 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins SH3_1 PF00018.28 EMC76891.1 - 0.00088 18.8 0.0 0.0018 17.8 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC76891.1 - 0.0015 18.4 0.0 0.0034 17.2 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC76891.1 - 0.0024 17.5 0.1 0.0077 15.9 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain LRR_8 PF13855.6 EMC76892.1 - 9.5e-40 134.2 56.9 3.7e-13 49.0 5.8 7.0 2 1 7 9 9 9 8 Leucine rich repeat LRR_5 PF13306.6 EMC76892.1 - 3.1e-21 75.7 0.3 1e-08 35.2 0.0 3.6 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 EMC76892.1 - 3e-19 68.8 48.9 0.00037 20.8 4.3 7.9 5 2 1 8 8 7 6 Leucine Rich repeats (2 copies) I-set PF07679.16 EMC76892.1 - 5.2e-13 48.9 0.0 3.3e-12 46.3 0.0 2.1 1 1 1 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC76892.1 - 1.4e-12 48.0 0.1 3.6e-12 46.7 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.6 EMC76892.1 - 3.3e-10 39.7 25.0 7.4e-05 22.3 0.8 4.4 1 1 2 4 4 4 4 Leucine-rich repeat ig PF00047.25 EMC76892.1 - 2.9e-08 33.8 0.0 6.2e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain fn3 PF00041.21 EMC76892.1 - 1e-07 32.2 0.1 2.3e-07 31.1 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III domain Ig_2 PF13895.6 EMC76892.1 - 4.9e-06 26.8 0.0 1.2e-05 25.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRRCT PF01463.24 EMC76892.1 - 0.002 18.5 0.1 0.0048 17.3 0.1 1.7 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain V-set PF07686.17 EMC76892.1 - 0.0039 17.4 0.2 0.5 10.6 0.2 2.5 1 1 0 1 1 1 1 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.5 EMC76892.1 - 0.033 14.7 0.1 0.097 13.3 0.1 1.8 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain Glyco_hydro_12 PF01670.16 EMC76892.1 - 0.15 12.0 0.2 0.27 11.2 0.2 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 12 LRRNT PF01462.18 EMC76892.1 - 0.55 9.9 7.9 0.069 12.8 1.1 3.2 4 0 0 4 4 4 0 Leucine rich repeat N-terminal domain COPIIcoated_ERV PF07970.12 EMC76893.1 - 1.5e-94 316.0 1.1 1.8e-94 315.7 1.1 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EMC76893.1 - 2e-12 47.3 0.1 8e-12 45.3 0.0 2.0 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Glyco_transf_29 PF00777.18 EMC76894.1 - 3.5e-14 52.9 0.0 3.7e-14 52.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Copine PF07002.16 EMC76896.1 - 1.8e-89 298.9 0.0 3.5e-89 298.0 0.0 1.5 2 0 0 2 2 2 1 Copine C2 PF00168.30 EMC76896.1 - 6.2e-24 84.3 0.0 1.9e-12 47.3 0.0 2.4 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 EMC76896.1 - 5.8e-06 26.6 0.0 9.1e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 EMC76896.1 - 0.011 16.0 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 0 von Willebrand factor type A domain RRM_1 PF00076.22 EMC76898.1 - 3.4e-30 103.7 2.1 4.1e-09 36.1 0.0 5.3 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EMC76898.1 - 0.041 13.9 0.3 3.3 7.8 0.0 3.3 5 0 0 5 5 5 0 RNA binding motif RRM_8 PF11835.8 EMC76898.1 - 0.24 11.6 0.0 0.82 9.9 0.0 1.8 2 0 0 2 2 2 0 RRM-like domain Aminotran_5 PF00266.19 EMC76899.1 - 1.7e-90 303.7 0.0 1.9e-90 303.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EMC76899.1 - 1.8e-08 34.1 0.0 2.8e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EMC76899.1 - 0.00081 18.8 0.0 0.0013 18.1 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.19 EMC76899.1 - 0.032 12.9 0.0 0.063 12.0 0.0 1.5 2 0 0 2 2 2 0 Pyridoxal-dependent decarboxylase conserved domain Cys_Met_Meta_PP PF01053.20 EMC76899.1 - 0.14 10.6 0.0 0.22 10.0 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme RRM_1 PF00076.22 EMC76900.1 - 2.5e-42 142.6 0.0 3.5e-24 84.4 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 EMC76900.1 - 5.6e-27 94.6 0.3 1.3e-26 93.5 0.3 1.6 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 EMC76900.1 - 2.9e-05 23.8 0.0 0.011 15.6 0.0 3.6 3 1 1 4 4 4 1 Occluded RNA-recognition motif RRM_5 PF13893.6 EMC76900.1 - 0.0033 17.0 0.0 0.44 10.1 0.0 2.7 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1866 PF08952.11 EMC76900.1 - 0.029 14.2 0.0 4.7 7.1 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1866) RRM_7 PF16367.5 EMC76900.1 - 0.19 11.9 0.0 1.3 9.2 0.0 2.5 2 1 0 2 2 2 0 RNA recognition motif Get5_bdg PF16843.5 EMC76901.1 - 0.065 12.7 0.0 0.18 11.3 0.0 1.7 2 0 0 2 2 2 0 Binding domain to Get4 on Get5, Golgi to ER traffic protein RhoGAP PF00620.27 EMC76902.1 - 2.2e-25 89.3 0.0 1e-24 87.1 0.0 2.2 2 0 0 2 2 2 1 RhoGAP domain MyTH4 PF00784.17 EMC76902.1 - 3.9e-25 88.5 0.2 2.3e-24 86.0 0.2 2.4 1 1 0 1 1 1 1 MyTH4 domain WW PF00397.26 EMC76902.1 - 4.2e-06 26.7 4.4 1.2e-05 25.3 4.4 1.8 1 0 0 1 1 1 1 WW domain DUF551 PF04448.12 EMC76902.1 - 0.0089 16.9 0.2 0.043 14.8 0.2 2.2 1 0 0 1 1 1 1 Protein of unknown function (DUF551) DUF3776 PF12618.8 EMC76903.1 - 1e-27 96.5 21.2 1e-27 96.5 21.2 4.8 4 2 1 5 5 3 1 Protein of unknown function (DUF3776) Tudor_3 PF18115.1 EMC76903.1 - 3.3e-15 55.6 1.2 3e-13 49.4 0.5 3.0 3 0 0 3 3 3 1 DNA repair protein Crb2 Tudor domain PHD PF00628.29 EMC76903.1 - 2.1e-06 27.5 12.3 1e-05 25.3 12.3 2.3 1 0 0 1 1 1 1 PHD-finger DUF4537 PF15057.6 EMC76903.1 - 1.5e-05 25.0 0.0 4.6e-05 23.4 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) Tudor_2 PF18104.1 EMC76903.1 - 1.8e-05 24.3 0.4 4.1e-05 23.2 0.4 1.6 1 0 0 1 1 1 1 Jumonji domain-containing protein 2A Tudor domain MBT PF02820.18 EMC76903.1 - 0.00029 21.1 0.6 0.0025 18.1 0.1 2.7 3 0 0 3 3 3 1 mbt repeat Tudor-knot PF11717.8 EMC76903.1 - 0.0027 17.6 2.2 0.011 15.7 1.4 2.5 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Rad9_Rad53_bind PF08605.10 EMC76903.1 - 0.0087 16.2 1.9 0.53 10.5 0.1 3.1 4 0 0 4 4 4 1 Fungal Rad9-like Rad53-binding LBR_tudor PF09465.10 EMC76903.1 - 0.014 15.2 0.0 0.031 14.1 0.0 1.6 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain Agenet PF05641.12 EMC76903.1 - 0.045 14.2 2.7 1.5 9.3 0.2 3.0 2 0 0 2 2 2 0 Agenet domain zf-C2H2 PF00096.26 EMC76903.1 - 4.6 7.9 10.9 0.61 10.7 5.4 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type SH2 PF00017.24 EMC76904.1 - 1.2e-20 73.3 0.0 1.8e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 SH2 domain SH3_2 PF07653.17 EMC76904.1 - 0.0042 16.7 0.0 0.0081 15.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EMC76904.1 - 0.0048 16.7 0.0 0.012 15.4 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EMC76904.1 - 0.01 15.4 0.0 0.023 14.3 0.0 1.6 2 0 0 2 2 2 0 SH3 domain SH3_16 PF18348.1 EMC76904.1 - 0.057 13.2 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial dipeptidyl-peptidase Sh3 domain Ndr PF03096.14 EMC76905.1 - 1.5e-125 417.6 0.0 1.7e-125 417.4 0.0 1.0 1 0 0 1 1 1 1 Ndr family Abhydrolase_1 PF00561.20 EMC76905.1 - 6.1e-06 26.1 0.0 0.00017 21.3 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold AvrM_N PF18247.1 EMC76906.1 - 0.43 10.6 4.7 0.94 9.5 0.9 3.7 3 0 0 3 3 3 0 Flax-rust effector AvrM N-terminal domain FmdA_AmdA PF03069.15 EMC76906.1 - 0.53 9.1 4.4 1.7 7.4 0.8 2.6 2 0 0 2 2 2 0 Acetamidase/Formamidase family MarR PF01047.22 EMC76906.1 - 5.2 7.1 11.2 2.9 7.9 0.5 4.0 3 1 1 4 4 4 0 MarR family Torsin PF06309.11 EMC76908.1 - 1.1e-38 132.2 0.1 4.9e-38 130.1 0.0 1.9 2 0 0 2 2 2 1 Torsin AAA_2 PF07724.14 EMC76908.1 - 0.00037 20.7 0.0 0.00072 19.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) ResIII PF04851.15 EMC76908.1 - 0.0041 17.1 0.0 0.0055 16.7 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA PF00004.29 EMC76908.1 - 0.0073 16.7 0.0 0.013 16.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EMC76908.1 - 0.02 15.2 0.1 5.6 7.2 0.2 2.3 1 1 1 2 2 2 0 AAA domain NB-ARC PF00931.22 EMC76908.1 - 0.031 13.5 0.0 0.057 12.6 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Viral_helicase1 PF01443.18 EMC76908.1 - 0.095 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_33 PF13671.6 EMC76908.1 - 0.15 12.2 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EMC76908.1 - 0.17 12.3 0.0 0.39 11.1 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain SH2 PF00017.24 EMC76909.1 - 1.3e-14 54.0 0.1 2.6e-14 53.1 0.1 1.5 1 0 0 1 1 1 1 SH2 domain RasGEF PF00617.19 EMC76909.1 - 2.4e-11 44.2 0.0 4e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 RasGEF domain Mur_ligase_M PF08245.12 EMC76910.1 - 0.16 12.0 0.0 0.16 11.9 0.0 1.1 1 0 0 1 1 1 0 Mur ligase middle domain ADK PF00406.22 EMC76911.1 - 2e-53 180.5 0.1 2.4e-53 180.3 0.1 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EMC76911.1 - 7.2e-38 130.1 0.3 9.1e-38 129.8 0.3 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMC76911.1 - 1.5e-07 32.0 0.0 2.1e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EMC76911.1 - 1.9e-07 31.3 0.0 4.4e-07 30.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EMC76911.1 - 2.6e-06 27.3 0.1 0.046 13.4 0.0 2.1 2 0 0 2 2 2 2 Thymidylate kinase AAA_22 PF13401.6 EMC76911.1 - 0.0068 16.7 0.6 0.067 13.5 0.2 2.3 2 2 0 2 2 2 1 AAA domain Ploopntkinase3 PF18751.1 EMC76911.1 - 0.015 15.3 0.1 0.032 14.1 0.0 1.7 2 1 0 2 2 2 0 P-loop Nucleotide Kinase3 Cytidylate_kin PF02224.18 EMC76911.1 - 0.018 14.8 0.0 0.13 12.0 0.0 2.0 2 0 0 2 2 2 0 Cytidylate kinase AAA_19 PF13245.6 EMC76911.1 - 0.032 14.6 0.1 0.064 13.6 0.1 1.4 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EMC76911.1 - 0.036 13.4 0.1 0.11 11.8 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin NTPase_1 PF03266.15 EMC76911.1 - 0.071 13.0 0.3 0.18 11.7 0.0 1.9 2 1 1 3 3 3 0 NTPase dNK PF01712.19 EMC76911.1 - 0.077 12.8 0.1 0.17 11.8 0.0 1.7 2 0 0 2 2 2 0 Deoxynucleoside kinase Arc_C PF18162.1 EMC76911.1 - 0.088 12.7 0.0 2.7 7.9 0.0 2.4 2 0 0 2 2 2 0 Arc C-lobe ABC_tran PF00005.27 EMC76911.1 - 0.15 12.5 0.1 1.4 9.4 0.0 2.1 2 0 0 2 2 2 0 ABC transporter Glyco_transf_29 PF00777.18 EMC76912.1 - 4.6e-34 118.0 0.1 5.5e-34 117.8 0.1 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) PIF PF05092.12 EMC76912.1 - 0.052 12.3 0.0 0.072 11.8 0.0 1.2 1 0 0 1 1 1 0 Per os infectivity DUF3808 PF10300.9 EMC76912.1 - 0.082 11.6 0.1 0.12 11.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) Tsi6 PF18660.1 EMC76912.1 - 0.19 11.8 0.0 0.31 11.1 0.0 1.3 1 0 0 1 1 1 0 Tsi6 DPM2 PF07297.12 EMC76913.1 - 7.8e-30 103.0 7.8 9.1e-30 102.8 7.8 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.12 EMC76913.1 - 1.7e-05 24.7 5.5 1.9e-05 24.6 5.5 1.1 1 0 0 1 1 1 1 PIG-P TMEM154 PF15102.6 EMC76913.1 - 0.0061 16.5 0.3 0.01 15.8 0.3 1.3 1 0 0 1 1 1 1 TMEM154 protein family Spem1 PF15670.5 EMC76913.1 - 0.024 14.2 0.1 0.028 14.0 0.1 1.1 1 0 0 1 1 1 0 Spermatid maturation protein 1 Phage_holin_3_6 PF07332.11 EMC76913.1 - 0.077 13.0 2.0 0.097 12.7 2.0 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III RDD PF06271.12 EMC76913.1 - 0.11 12.6 5.8 0.14 12.3 5.8 1.1 1 0 0 1 1 1 0 RDD family DUF1673 PF07895.11 EMC76913.1 - 0.25 11.0 5.0 0.3 10.8 5.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) LAX PF15681.5 EMC76913.1 - 0.29 9.9 0.4 0.37 9.6 0.4 1.1 1 0 0 1 1 1 0 Lymphocyte activation family X EphA2_TM PF14575.6 EMC76913.1 - 0.47 11.4 0.2 0.47 11.4 0.2 1.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DHHC PF01529.20 EMC76913.1 - 0.99 9.5 5.6 1.2 9.2 5.6 1.1 1 0 0 1 1 1 0 DHHC palmitoyltransferase DUF2207 PF09972.9 EMC76913.1 - 3.9 6.1 5.2 4.9 5.8 5.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Ndc1_Nup PF09531.10 EMC76913.1 - 4 6.0 6.8 4.6 5.8 6.8 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NT-C2 PF10358.9 EMC76914.1 - 7.5e-30 103.6 0.0 1.6e-29 102.5 0.0 1.6 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins Myb_DNA-bind_5 PF13873.6 EMC76915.1 - 4e-25 87.7 1.2 4e-25 87.7 1.2 1.7 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.9 EMC76915.1 - 0.00017 21.9 0.6 0.0007 19.9 0.0 2.1 2 0 0 2 2 2 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Peptidase_S68 PF10461.9 EMC76915.1 - 0.07 13.3 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 Peptidase S68 DUF3450 PF11932.8 EMC76915.1 - 0.091 12.0 9.2 0.098 11.9 6.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Lipoprotein_7 PF01540.16 EMC76915.1 - 0.25 10.6 1.3 0.31 10.3 0.1 1.6 2 0 0 2 2 2 0 Adhesin lipoprotein Mito_carr PF00153.27 EMC76916.1 - 3.7e-74 244.7 2.2 5.5e-25 87.1 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 EMC76916.1 - 1.3e-14 54.4 2.9 9.3e-11 42.0 0.5 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EMC76916.1 - 1e-13 49.8 2.9 0.0014 18.0 0.2 3.5 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 EMC76916.1 - 8.4e-12 44.0 3.4 0.0003 20.5 0.1 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 EMC76916.1 - 5.5e-08 32.5 2.0 0.0046 16.8 0.1 2.9 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EMC76916.1 - 1.6e-06 27.3 2.7 0.0023 17.3 0.1 3.3 3 1 0 3 3 3 2 EF hand EF-hand_10 PF14788.6 EMC76916.1 - 0.00048 19.9 0.6 2 8.3 0.0 3.7 2 1 1 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.9 EMC76916.1 - 0.0019 18.5 1.0 0.0042 17.4 1.0 1.5 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EMC76916.1 - 0.047 13.7 2.5 0.57 10.2 0.2 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand DUF1002 PF06207.11 EMC76916.1 - 0.083 12.4 0.1 0.13 11.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) DUF2624 PF11116.8 EMC76916.1 - 0.14 13.1 0.0 0.29 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2624) ApoM PF11032.8 EMC76917.1 - 4.1e-10 39.6 0.0 5.1e-10 39.3 0.0 1.0 1 0 0 1 1 1 1 ApoM domain Lipocalin PF00061.23 EMC76917.1 - 3.1e-07 30.7 0.0 4.2e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family LRR_6 PF13516.6 EMC76918.1 - 0.0011 18.8 0.5 0.76 10.0 0.0 3.1 3 0 0 3 3 3 2 Leucine Rich repeat LRR_4 PF12799.7 EMC76918.1 - 0.06 13.8 0.3 4.8 7.7 0.1 2.9 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) VPS28 PF03997.12 EMC76919.1 - 1.3e-36 126.1 0.0 4.2e-36 124.4 0.0 1.7 1 1 0 1 1 1 1 VPS28 protein KRAB PF01352.27 EMC76921.1 - 1.7e-11 43.5 5.5 6.1e-11 41.8 5.5 1.7 1 1 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.6 EMC76922.1 - 9.1e-97 313.6 106.7 5.1e-08 33.0 0.4 16.5 17 0 0 17 17 16 15 Zinc-finger double domain zf-C2H2 PF00096.26 EMC76922.1 - 8.3e-67 218.1 144.6 2.9e-07 30.6 0.8 17.3 17 0 0 17 17 17 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC76922.1 - 8.1e-36 119.6 142.3 0.0026 18.4 0.9 17.5 18 0 0 18 18 17 14 C2H2-type zinc finger zf-LYAR PF08790.11 EMC76922.1 - 8.9e-28 95.9 86.1 0.012 15.5 0.2 14.4 14 0 0 14 14 14 11 LYAR-type C2HC zinc finger KRAB PF01352.27 EMC76922.1 - 8e-21 73.4 0.2 1.4e-20 72.6 0.2 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.8 EMC76922.1 - 2e-17 63.0 61.8 0.33 11.3 0.0 15.5 16 0 0 16 16 15 8 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 EMC76922.1 - 6.5e-12 44.8 64.1 0.072 12.7 0.1 14.3 13 1 1 14 14 14 5 Ubiquitin-Binding Zinc Finger zf-C2HE PF16278.5 EMC76922.1 - 8.7e-10 38.9 90.7 0.34 11.4 5.1 14.4 3 2 11 14 14 14 6 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_8 PF15909.5 EMC76922.1 - 7.5e-09 35.8 59.0 0.14 12.5 0.9 8.2 1 1 8 9 9 9 5 C2H2-type zinc ribbon zf-trcl PF13451.6 EMC76922.1 - 9.9e-08 31.8 69.0 2.9 7.9 0.2 14.1 14 0 0 14 14 14 4 Probable zinc-ribbon domain Zn-ribbon_8 PF09723.10 EMC76922.1 - 3.8e-07 30.1 76.9 0.052 13.7 2.2 10.2 4 3 10 14 14 13 8 Zinc ribbon domain zf_C2H2_ZHX PF18387.1 EMC76922.1 - 4.3e-07 29.5 71.4 0.11 12.2 0.0 13.2 3 3 10 14 14 14 5 Zinc-fingers and homeoboxes C2H2 finger domain ADK_lid PF05191.14 EMC76922.1 - 7.9e-07 29.0 44.0 0.37 10.8 1.5 10.5 5 3 6 11 11 11 1 Adenylate kinase, active site lid zf-C2H2_6 PF13912.6 EMC76922.1 - 7e-06 25.9 99.4 0.012 15.6 0.6 15.3 14 1 0 14 14 13 5 C2H2-type zinc finger TFIIS_C PF01096.18 EMC76922.1 - 3.7e-05 23.5 69.0 11 6.0 2.8 14.2 14 0 0 14 14 14 0 Transcription factor S-II (TFIIS) CpXC PF14353.6 EMC76922.1 - 0.00036 20.6 58.1 0.64 10.1 1.0 13.1 3 1 10 14 14 13 1 CpXC protein FYDLN_acid PF09538.10 EMC76922.1 - 0.00074 20.2 40.0 39 5.0 0.0 12.4 4 4 7 12 12 12 0 Protein of unknown function (FYDLN_acid) FAM178 PF14816.6 EMC76922.1 - 0.0017 17.4 17.2 2.8 6.8 0.1 7.8 2 2 8 10 10 10 1 Family of unknown function, FAM178 YhfH PF14149.6 EMC76922.1 - 0.0025 17.7 69.3 15 5.6 0.1 14.0 14 0 0 14 14 14 0 YhfH-like protein LIM PF00412.22 EMC76922.1 - 0.0046 17.2 88.8 1 9.7 2.1 14.0 5 3 8 14 14 12 3 LIM domain XPA_N PF01286.18 EMC76922.1 - 0.0067 16.4 73.0 11 6.2 0.1 14.1 14 0 0 14 14 14 0 XPA protein N-terminal DUF4712 PF15830.5 EMC76922.1 - 0.017 14.8 0.1 11 5.6 0.0 3.6 1 1 2 4 4 4 0 Domain of unknown function (DUF4712) DUF3268 PF11672.8 EMC76922.1 - 0.032 14.6 32.9 0.89 9.9 0.2 7.4 4 2 2 8 8 8 0 zinc-finger-containing domain C1_4 PF07975.12 EMC76922.1 - 0.071 13.4 0.8 0.071 13.4 0.8 9.5 6 3 2 10 10 8 0 TFIIH C1-like domain zf-AN1 PF01428.16 EMC76922.1 - 0.098 12.8 85.9 5.7 7.2 1.7 14.6 11 3 3 14 14 14 0 AN1-like Zinc finger Secretogranin_V PF05281.11 EMC76922.1 - 0.8 9.3 4.4 19 4.8 0.1 3.0 2 2 0 2 2 2 0 Neuroendocrine protein 7B2 precursor (Secretogranin V) A_deaminase PF00962.22 EMC76922.1 - 1.1 8.5 6.2 12 5.1 0.1 3.4 3 1 0 3 3 3 0 Adenosine/AMP deaminase BDHCT_assoc PF16204.5 EMC76922.1 - 2 8.1 11.1 5.9 6.5 0.2 3.9 1 1 0 3 3 3 0 BDHCT-box associated domain on Bloom syndrome protein zf-C2H2_11 PF16622.5 EMC76922.1 - 2.7 7.8 86.8 0.97 9.3 0.4 13.9 14 0 0 14 14 14 0 zinc-finger C2H2-type Med13_C PF06333.12 EMC76923.1 - 4.1e-118 394.4 0.3 4.1e-118 394.4 0.3 3.4 5 0 0 5 5 5 1 Mediator complex subunit 13 C-terminal domain MID_MedPIWI PF18296.1 EMC76923.1 - 3.1e-99 331.8 1.2 7.1e-98 327.3 0.0 3.1 3 0 0 3 3 3 1 MID domain of medPIWI Med13_N PF11597.8 EMC76923.1 - 1e-11 44.8 0.0 2.9e-11 43.3 0.0 1.7 2 0 0 2 2 2 1 Mediator complex subunit 13 N-terminal DUF2054 PF10218.9 EMC76924.1 - 1.8e-44 151.0 18.7 2.5e-44 150.6 18.7 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2054) DUF3369 PF11849.8 EMC76924.1 - 0.078 13.2 0.1 0.17 12.1 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3369) APS-reductase_C PF12139.8 EMC76924.1 - 0.19 12.0 0.0 0.31 11.3 0.0 1.3 1 0 0 1 1 1 0 Adenosine-5'-phosphosulfate reductase beta subunit WD40 PF00400.32 EMC76925.1 - 4.5e-09 36.8 6.4 1.1 10.2 0.0 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat BBS2_Mid PF14783.6 EMC76925.1 - 0.028 14.5 0.0 0.11 12.6 0.0 1.9 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Transglut_core2 PF13369.6 EMC76926.1 - 1.5e-42 144.8 0.0 2.4e-42 144.1 0.0 1.3 1 0 0 1 1 1 1 Transglutaminase-like superfamily YccV-like PF08755.11 EMC76926.1 - 4.9e-29 100.7 0.4 8.9e-28 96.7 0.0 2.8 2 1 0 2 2 2 1 Hemimethylated DNA-binding protein YccV like NO_synthase PF02898.15 EMC76927.1 - 4.5e-189 628.0 0.0 6.8e-189 627.4 0.0 1.3 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain FAD_binding_1 PF00667.20 EMC76927.1 - 3.6e-84 281.8 0.3 2.3e-83 279.2 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain Flavodoxin_1 PF00258.25 EMC76927.1 - 4.4e-30 104.8 0.8 1.1e-28 100.2 0.3 2.8 2 1 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 EMC76927.1 - 1.5e-20 73.8 0.0 4.8e-20 72.2 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain PDZ PF00595.24 EMC76927.1 - 2.7e-15 56.5 0.0 5.9e-15 55.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC76927.1 - 2.8e-08 33.5 0.1 7.8e-08 32.1 0.1 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC76927.1 - 0.00059 20.1 0.1 0.0014 18.9 0.1 1.6 1 0 0 1 1 1 1 PDZ domain Pkinase_Tyr PF07714.17 EMC76928.1 - 4.5e-38 131.0 0.0 8.8e-38 130.1 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC76928.1 - 3.2e-35 121.8 0.0 4.7e-35 121.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain C1_1 PF00130.22 EMC76928.1 - 2e-05 24.4 11.8 4.2e-05 23.3 11.8 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.6 EMC76928.1 - 0.019 14.3 0.0 0.033 13.5 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 EMC76928.1 - 0.024 14.0 0.0 0.045 13.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EMC76928.1 - 0.025 14.2 0.0 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 RIO1 family zf-RING-like PF08746.11 EMC76928.1 - 0.061 13.6 6.9 0.15 12.4 6.9 1.7 1 0 0 1 1 1 0 RING-like domain FTA2 PF13095.6 EMC76928.1 - 0.12 12.0 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EMC76928.1 - 0.13 12.2 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family C1_2 PF03107.16 EMC76928.1 - 0.34 11.3 6.5 0.79 10.1 6.5 1.6 1 0 0 1 1 1 0 C1 domain Rep_fac_C PF08542.11 EMC76929.1 - 7e-25 87.3 0.1 2e-24 85.8 0.1 1.8 2 0 0 2 2 1 1 Replication factor C C-terminal domain AAA PF00004.29 EMC76929.1 - 8.6e-16 58.6 0.0 1.5e-15 57.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EMC76929.1 - 9.3e-14 51.5 0.0 4.5e-11 42.8 0.0 2.2 1 1 1 2 2 2 2 DNA polymerase III, delta subunit AAA_24 PF13479.6 EMC76929.1 - 6.7e-06 26.0 0.0 1.4e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EMC76929.1 - 6.8e-06 26.4 0.2 0.026 14.8 0.0 3.0 2 1 1 3 3 3 2 AAA domain AAA_16 PF13191.6 EMC76929.1 - 8.9e-06 26.2 0.0 1.8e-05 25.2 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_11 PF13086.6 EMC76929.1 - 1.6e-05 24.8 0.0 0.0003 20.7 0.0 2.1 1 1 0 2 2 2 1 AAA domain AAA_assoc_2 PF16193.5 EMC76929.1 - 3.5e-05 24.0 0.0 7.3e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 AAA C-terminal domain AAA_19 PF13245.6 EMC76929.1 - 0.0002 21.7 0.1 0.017 15.4 0.0 2.7 2 1 0 3 3 3 1 AAA domain DNA_pol3_delta PF06144.13 EMC76929.1 - 0.00028 20.7 0.0 0.00066 19.5 0.0 1.5 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA_5 PF07728.14 EMC76929.1 - 0.00053 20.0 0.1 0.0031 17.5 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EMC76929.1 - 0.0011 18.7 0.0 0.02 14.6 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EMC76929.1 - 0.0013 18.7 0.0 0.0023 18.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 EMC76929.1 - 0.0015 18.3 0.1 0.033 14.0 0.0 2.5 1 1 1 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EMC76929.1 - 0.0018 18.3 0.0 0.54 10.2 0.0 2.2 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit PhoH PF02562.16 EMC76929.1 - 0.0032 16.9 0.1 0.15 11.4 0.0 2.4 1 1 0 2 2 2 1 PhoH-like protein RuvB_N PF05496.12 EMC76929.1 - 0.0049 16.6 0.0 0.012 15.3 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TniB PF05621.11 EMC76929.1 - 0.0077 15.7 0.0 0.18 11.2 0.0 2.2 2 0 0 2 2 2 1 Bacterial TniB protein DUF815 PF05673.13 EMC76929.1 - 0.014 14.6 0.0 0.024 13.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 EMC76929.1 - 0.016 14.7 0.0 0.028 13.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 EMC76929.1 - 0.017 14.7 0.0 0.27 10.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EMC76929.1 - 0.021 14.6 0.1 0.15 11.8 0.1 2.1 1 1 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 EMC76929.1 - 0.043 13.0 0.0 0.1 11.8 0.0 1.6 2 0 0 2 2 2 0 TIP49 P-loop domain Mg_chelatase PF01078.21 EMC76929.1 - 0.048 13.0 0.0 0.71 9.2 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Hydantoinase_B PF02538.14 EMC76929.1 - 0.072 11.5 0.0 0.11 10.9 0.0 1.2 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase AAA_3 PF07726.11 EMC76929.1 - 0.087 12.7 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SNF2_N PF00176.23 EMC76929.1 - 0.1 11.3 0.0 0.15 10.8 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain Thioredoxin_6 PF13848.6 EMC76929.1 - 0.15 12.0 0.0 0.62 10.0 0.0 1.9 2 0 0 2 2 2 0 Thioredoxin-like domain AAA_18 PF13238.6 EMC76929.1 - 0.17 12.4 0.0 0.52 10.8 0.0 1.8 1 1 1 2 2 2 0 AAA domain WD40 PF00400.32 EMC76930.1 - 4.1e-20 71.7 0.4 3.8e-07 30.7 0.1 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat SOCS_box PF07525.16 EMC76930.1 - 4.9e-09 36.4 0.8 9.2e-09 35.5 0.8 1.5 1 0 0 1 1 1 1 SOCS box Ge1_WD40 PF16529.5 EMC76930.1 - 5.9e-05 22.2 0.0 0.43 9.5 0.0 3.0 1 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 EMC76930.1 - 0.00026 21.2 0.0 2.5 8.5 0.0 3.0 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain C2 PF00168.30 EMC76931.1 - 3.3e-41 139.7 0.0 1.3e-21 76.8 0.0 2.3 2 0 0 2 2 2 2 C2 domain RasGAP PF00616.19 EMC76931.1 - 5.2e-37 127.6 0.0 8.5e-37 126.9 0.0 1.3 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase ArgoMid PF16487.5 EMC76932.1 - 0.058 13.7 0.0 0.084 13.1 0.0 1.3 1 0 0 1 1 1 0 Mid domain of argonaute EpoR_lig-bind PF09067.10 EMC76932.1 - 0.25 11.6 4.6 0.22 11.7 3.7 1.5 1 1 0 1 1 1 0 Erythropoietin receptor, ligand binding Filament PF00038.21 EMC76934.1 - 1.1e-38 133.6 15.5 1.2e-38 133.5 15.5 1.0 1 0 0 1 1 1 1 Intermediate filament protein GBP_C PF02841.14 EMC76934.1 - 0.0011 18.4 9.1 0.0012 18.4 9.1 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain DUF4515 PF14988.6 EMC76934.1 - 0.01 15.7 12.0 0.049 13.5 4.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4515) UPF0242 PF06785.11 EMC76934.1 - 0.036 14.2 10.1 0.046 13.8 10.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus APG6_N PF17675.1 EMC76934.1 - 0.046 14.3 16.4 0.72 10.4 7.8 2.0 1 1 1 2 2 2 0 Apg6 coiled-coil region Phage_GP20 PF06810.11 EMC76934.1 - 0.14 11.9 7.6 0.9 9.3 7.6 1.9 1 1 0 1 1 1 0 Phage minor structural protein GP20 Atg14 PF10186.9 EMC76934.1 - 0.17 10.9 5.8 0.18 10.8 5.8 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 COG2 PF06148.11 EMC76934.1 - 0.19 11.8 6.9 1.3 9.1 3.1 2.1 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 HHH_8 PF14716.6 EMC76934.1 - 0.28 11.6 3.8 2.7 8.5 0.3 2.7 2 1 1 3 3 3 0 Helix-hairpin-helix domain BMP2K_C PF15282.6 EMC76934.1 - 0.3 10.9 1.2 0.33 10.8 1.2 1.1 1 0 0 1 1 1 0 BMP-2-inducible protein kinase C-terminus OmpH PF03938.14 EMC76934.1 - 0.3 11.4 10.0 0.38 11.1 10.0 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) V_ATPase_I PF01496.19 EMC76934.1 - 0.42 8.5 4.7 0.46 8.3 4.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FliJ PF02050.16 EMC76934.1 - 0.47 10.7 16.7 1.4 9.1 6.4 1.8 1 1 1 2 2 2 0 Flagellar FliJ protein Uso1_p115_C PF04871.13 EMC76934.1 - 0.48 10.8 11.8 0.58 10.5 11.8 1.1 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Selenoprotein_S PF06936.11 EMC76934.1 - 0.65 9.8 8.1 0.95 9.2 8.1 1.4 1 1 0 1 1 1 0 Selenoprotein S (SelS) DUF4337 PF14235.6 EMC76934.1 - 0.86 9.7 7.0 0.99 9.5 7.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) FAM76 PF16046.5 EMC76934.1 - 1.1 8.6 5.2 1.3 8.3 5.2 1.1 1 0 0 1 1 1 0 FAM76 protein Tup_N PF08581.10 EMC76934.1 - 1.1 9.6 12.0 0.73 10.2 7.9 2.5 2 1 0 2 2 2 0 Tup N-terminal Bap31_Bap29_C PF18035.1 EMC76934.1 - 1.3 9.1 9.4 0.73 9.9 2.5 2.7 2 1 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain FapA PF03961.13 EMC76934.1 - 2.1 6.9 5.5 2.2 6.8 5.5 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Spc24 PF08286.11 EMC76934.1 - 3.4 8.0 9.8 16 5.8 9.8 1.9 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 DUF4407 PF14362.6 EMC76934.1 - 9.3 5.5 10.9 10 5.4 6.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) NIPSNAP PF07978.13 EMC76935.1 - 1.3e-33 115.2 0.5 1.8e-33 114.8 0.5 1.2 1 0 0 1 1 1 1 NIPSNAP EF-hand_1 PF00036.32 EMC76936.1 - 2e-18 64.5 2.4 1.1e-09 37.1 0.1 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EMC76936.1 - 7.9e-15 53.5 0.4 2.6e-09 36.3 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EMC76936.1 - 5.7e-14 50.9 2.7 1.7e-06 27.3 0.1 2.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EMC76936.1 - 5.9e-14 51.7 0.6 1.3e-10 40.9 0.2 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 EMC76936.1 - 2.1e-13 50.5 0.1 3.4e-13 49.8 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_9 PF14658.6 EMC76936.1 - 5.7e-05 23.4 0.0 8.5e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.7 EMC76936.1 - 0.0048 16.8 0.0 0.0088 16.0 0.0 1.4 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EMC76936.1 - 0.046 14.0 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region zf-CCCH PF00642.24 EMC76937.1 - 4.1e-08 32.9 1.6 6.6e-08 32.3 1.6 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-U1 PF06220.12 EMC76937.1 - 7.5e-08 32.0 4.1 1.4e-07 31.1 4.1 1.5 1 0 0 1 1 1 1 U1 zinc finger zf-CCCH_4 PF18044.1 EMC76937.1 - 2.2e-07 30.5 1.8 3.9e-07 29.7 1.8 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EMC76937.1 - 4.3e-06 26.6 2.4 7.3e-06 25.9 2.4 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_2 PF14608.6 EMC76937.1 - 0.0022 18.4 1.4 0.0037 17.7 1.4 1.4 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger DUF4127 PF13552.6 EMC76937.1 - 0.11 11.1 0.0 0.3 9.6 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4127) DUF4239 PF14023.6 EMC76937.1 - 0.17 11.6 0.1 0.26 11.0 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4239) zf-C2H2_jaz PF12171.8 EMC76937.1 - 1.2 9.5 6.9 6.7 7.1 6.9 2.1 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Acyl-CoA_dh_1 PF00441.24 EMC76939.1 - 2.2e-29 102.6 0.7 2.2e-29 102.6 0.7 2.3 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, C-terminal domain AidB_N PF18158.1 EMC76939.1 - 9.2e-27 93.9 0.0 3.4e-25 88.8 0.0 2.5 2 1 0 2 2 2 1 Adaptive response protein AidB N-terminal domain Acyl-CoA_dh_M PF02770.19 EMC76939.1 - 2.2e-14 53.4 0.1 3.7e-14 52.7 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EMC76939.1 - 8.3e-08 32.6 1.2 4e-07 30.4 0.0 2.2 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain HORMA PF02301.18 EMC76940.1 - 1e-49 169.0 0.0 7.1e-49 166.3 0.0 2.0 1 1 0 1 1 1 1 HORMA domain LIF_OSM PF01291.17 EMC76941.1 - 9e-26 90.9 0.4 1e-25 90.8 0.4 1.0 1 0 0 1 1 1 1 LIF / OSM family DUF4239 PF14023.6 EMC76941.1 - 0.14 11.8 0.1 3 7.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) ACT_7 PF13840.6 EMC76942.1 - 1.1e-13 50.7 0.0 1.8e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 ACT domain RabGAP-TBC PF00566.18 EMC76943.1 - 3.6e-55 186.9 0.0 5.2e-55 186.4 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain ZNRF_3_ecto PF18212.1 EMC76944.1 - 2.4e-05 24.3 0.1 3.4e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 ZNRF-3 Ectodomain CRAL_TRIO PF00650.20 EMC76945.1 - 5e-42 143.3 0.0 7.4e-42 142.8 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain GOLD_2 PF13897.6 EMC76945.1 - 6.8e-09 36.3 0.3 3.2e-05 24.5 0.0 2.4 1 1 1 2 2 2 2 Golgi-dynamics membrane-trafficking CRAL_TRIO_2 PF13716.6 EMC76945.1 - 2.4e-06 27.8 0.0 4.2e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EMC76945.1 - 0.0004 20.5 0.3 0.00097 19.3 0.3 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain MTP18 PF10558.9 EMC76946.1 - 0.0072 16.3 0.1 0.0084 16.1 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) Gal-3-0_sulfotr PF06990.11 EMC76947.1 - 1.5e-165 551.0 0.2 1.8e-165 550.7 0.2 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Pescadillo_N PF06732.11 EMC76948.1 - 7.1e-126 419.3 0.7 7.1e-126 419.3 0.7 2.3 2 1 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 EMC76948.1 - 2.5e-07 31.0 0.0 5.5e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain CENP-B_dimeris PF09026.10 EMC76948.1 - 0.91 10.0 16.8 2.5 8.6 16.8 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 EMC76948.1 - 2.1 6.4 23.3 3.2 5.7 23.3 1.3 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 EMC76948.1 - 2.7 6.2 25.2 5.6 5.1 25.2 1.6 1 0 0 1 1 1 0 CDC45-like protein SIR4_SID PF16991.5 EMC76948.1 - 3 7.9 14.9 6.4 6.8 14.9 1.6 1 0 0 1 1 1 0 Sir4 SID domain PRAS PF15798.5 EMC76948.1 - 9.7 6.8 12.7 4.9 7.8 9.9 1.9 2 0 0 2 2 2 0 Proline-rich AKT1 substrate 1 Cobalamin_bind PF01122.19 EMC76949.1 - 3.9e-70 236.3 0.0 4.3e-70 236.1 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic cobalamin-binding protein IQ PF00612.27 EMC76950.1 - 2.8e-07 29.7 2.8 2.5e-06 26.8 0.9 2.7 2 0 0 2 2 2 1 IQ calmodulin-binding motif GAS PF13851.6 EMC76950.1 - 0.0062 15.9 7.9 0.0062 15.9 7.9 2.6 2 0 0 2 2 2 2 Growth-arrest specific micro-tubule binding CAP59_mtransfer PF11735.8 EMC76950.1 - 0.55 9.9 4.7 0.15 11.8 0.3 2.0 2 0 0 2 2 2 0 Cryptococcal mannosyltransferase 1 OmpH PF03938.14 EMC76950.1 - 6.2 7.2 15.8 0.2 12.0 7.9 2.4 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) Oxysterol_BP PF01237.18 EMC76951.1 - 6.6e-31 107.5 0.3 7.3e-31 107.3 0.3 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein LRR_8 PF13855.6 EMC76952.1 - 5.4e-39 131.8 30.8 8.1e-13 47.9 1.4 4.7 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EMC76952.1 - 9.7e-16 57.6 33.2 0.00034 21.0 3.5 5.8 4 1 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC76952.1 - 2.4e-15 56.6 0.0 3.1e-09 36.9 0.0 2.6 2 1 1 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC76952.1 - 3e-06 26.8 7.5 0.0003 20.4 1.8 2.6 1 1 1 2 2 2 2 Leucine-rich repeat LRRNT PF01462.18 EMC76952.1 - 0.0062 16.2 1.5 0.0062 16.2 1.5 2.1 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 EMC76952.1 - 1.1 10.0 24.7 16 6.6 0.5 8.5 8 1 0 8 8 8 0 Leucine Rich Repeat Pro_dh PF01619.18 EMC76953.1 - 1.2e-51 176.0 0.6 7.2e-50 170.2 0.6 2.0 1 1 0 1 1 1 1 Proline dehydrogenase HrpB2 PF09487.10 EMC76953.1 - 0.065 13.7 1.1 0.13 12.7 0.1 1.9 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB2) DGCR6 PF07324.11 EMC76954.1 - 2e-51 174.4 5.5 2.2e-51 174.3 5.5 1.0 1 0 0 1 1 1 1 DiGeorge syndrome critical region 6 (DGCR6) protein AA_permease_2 PF13520.6 EMC76955.1 - 8.6e-46 156.6 35.2 8.6e-46 156.6 35.2 2.1 2 0 0 2 2 2 1 Amino acid permease AA_permease PF00324.21 EMC76955.1 - 6.3e-38 130.6 40.3 1.2e-37 129.7 31.9 2.2 2 0 0 2 2 2 2 Amino acid permease AA_permease_C PF13906.6 EMC76955.1 - 9.6e-21 73.6 8.5 9.6e-21 73.6 8.5 3.9 4 0 0 4 4 4 1 C-terminus of AA_permease P2X_receptor PF00864.19 EMC76956.1 - 1.7e-88 297.2 0.1 2e-88 297.0 0.1 1.0 1 0 0 1 1 1 1 ATP P2X receptor WAP PF00095.21 EMC76956.1 - 1.3 9.5 7.2 0.15 12.4 1.1 2.6 2 1 0 2 2 2 0 WAP-type (Whey Acidic Protein) 'four-disulfide core' Transmemb_17 PF09799.9 EMC76957.1 - 2.2e-18 66.8 2.7 2.5e-18 66.6 2.7 1.0 1 0 0 1 1 1 1 Predicted membrane protein Pyr_redox_2 PF07992.14 EMC76958.1 - 1.2e-61 208.6 0.2 1.7e-61 208.1 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMC76958.1 - 1.9e-19 70.0 3.9 1.2e-15 57.8 0.8 3.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 EMC76958.1 - 2e-18 66.1 0.2 4.6e-18 64.9 0.2 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Pyr_redox_3 PF13738.6 EMC76958.1 - 4.4e-18 65.6 2.9 6.7e-14 51.8 0.4 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Reductase_C PF14759.6 EMC76958.1 - 7.2e-09 36.1 0.0 1.7e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 Reductase C-terminal HI0933_like PF03486.14 EMC76958.1 - 9.7e-09 34.4 1.9 0.0038 16.0 0.1 4.1 3 1 1 4 4 4 2 HI0933-like protein Rieske_2 PF13806.6 EMC76958.1 - 1.3e-07 31.5 0.0 9.6e-07 28.7 0.0 2.3 2 0 0 2 2 2 1 Rieske-like [2Fe-2S] domain NAD_binding_8 PF13450.6 EMC76958.1 - 1.4e-07 31.6 0.3 0.00026 21.1 0.1 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMC76958.1 - 6.3e-07 29.3 0.5 0.086 12.4 0.0 3.3 3 0 0 3 3 3 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMC76958.1 - 9.4e-06 24.9 4.0 0.0015 17.7 0.1 3.7 3 1 1 4 4 4 1 FAD binding domain FAD_binding_3 PF01494.19 EMC76958.1 - 3.6e-05 23.2 1.2 0.0016 17.7 0.0 2.9 3 0 0 3 3 3 1 FAD binding domain Shikimate_DH PF01488.20 EMC76958.1 - 0.00053 20.1 0.1 0.28 11.2 0.0 2.8 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Thi4 PF01946.17 EMC76958.1 - 0.00073 18.8 0.1 0.19 11.0 0.0 2.8 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.22 EMC76958.1 - 0.00095 18.3 2.2 1.1 8.2 0.0 3.5 3 1 1 4 4 4 2 Glucose inhibited division protein A TrkA_N PF02254.18 EMC76958.1 - 0.0011 19.2 0.8 0.24 11.7 0.0 2.9 3 0 0 3 3 2 1 TrkA-N domain Lycopene_cycl PF05834.12 EMC76958.1 - 0.0014 17.7 4.5 0.98 8.4 0.1 3.4 2 2 1 3 3 3 2 Lycopene cyclase protein NAD_binding_9 PF13454.6 EMC76958.1 - 0.0025 17.8 2.7 0.48 10.4 0.1 3.2 2 2 1 4 4 4 1 FAD-NAD(P)-binding DUF1188 PF06690.11 EMC76958.1 - 0.0028 17.3 0.0 0.43 10.1 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1188) K_oxygenase PF13434.6 EMC76958.1 - 0.014 14.5 0.0 0.12 11.5 0.1 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_7 PF13241.6 EMC76958.1 - 0.03 14.8 1.2 4 7.9 0.0 3.0 2 1 0 3 3 3 0 Putative NAD(P)-binding ThiF PF00899.21 EMC76958.1 - 0.04 13.3 1.6 0.58 9.5 0.0 2.6 3 0 0 3 3 2 0 ThiF family UDPG_MGDP_dh_N PF03721.14 EMC76958.1 - 0.086 12.4 0.8 3.2 7.3 0.1 2.6 2 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PglD_N PF17836.1 EMC76958.1 - 0.12 13.0 0.0 1.1 10.0 0.0 2.4 2 0 0 2 2 2 0 PglD N-terminal domain AlaDh_PNT_C PF01262.21 EMC76958.1 - 1.1 8.5 0.0 1.1 8.5 0.0 2.8 2 1 1 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain CARD PF00619.21 EMC76959.1 - 2.1e-16 59.7 2.7 3.3e-16 59.1 2.7 1.3 1 0 0 1 1 1 1 Caspase recruitment domain ubiquitin PF00240.23 EMC76959.1 - 2.7e-11 43.0 0.0 4.2e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EMC76959.1 - 0.00044 20.0 0.1 0.0011 18.8 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like PNTB PF02233.16 EMC76960.1 - 6.8e-184 612.1 27.7 9.4e-184 611.6 17.5 2.2 2 0 0 2 2 2 2 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 EMC76960.1 - 3.3e-71 239.0 0.4 7.4e-71 237.8 0.4 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 EMC76960.1 - 1.1e-45 155.3 0.6 4.8e-45 153.2 0.1 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 EMC76960.1 - 3e-32 110.9 2.9 3e-32 110.9 2.9 5.0 5 1 0 5 5 5 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 EMC76960.1 - 0.0078 15.6 1.0 0.8 9.0 0.2 2.9 2 1 1 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TPP_enzyme_M PF00205.22 EMC76960.1 - 0.036 13.8 0.0 11 5.8 0.0 2.9 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain MIF4G PF02854.19 EMC76961.1 - 5.2e-32 111.2 0.2 7.3e-32 110.7 0.2 1.2 1 0 0 1 1 1 1 MIF4G domain PAM2 PF07145.15 EMC76961.1 - 0.005 16.5 0.0 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 Ataxin-2 C-terminal region LepB_N PF18640.1 EMC76961.1 - 0.15 11.7 0.0 0.32 10.6 0.0 1.5 1 0 0 1 1 1 0 LepB N-terminal domain YdjM PF04307.14 EMC76962.1 - 0.00038 19.8 9.4 0.0012 18.2 9.6 1.7 1 1 1 2 2 2 1 LexA-binding, inner membrane-associated putative hydrolase HMG_CoA_synt_C PF08540.10 EMC76963.1 - 4e-127 423.6 0.6 5e-127 423.3 0.6 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 EMC76963.1 - 3.6e-108 359.1 0.5 5.1e-108 358.6 0.5 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal ACP_syn_III PF08545.10 EMC76963.1 - 0.0031 17.3 0.1 0.0083 16.0 0.1 1.7 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Phage_holin_7_1 PF16081.5 EMC76963.1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.3 1 0 0 1 1 1 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family Pkinase PF00069.25 EMC76964.1 - 2e-70 237.2 0.0 3.2e-70 236.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC76964.1 - 8.7e-40 136.6 0.0 1.3e-39 136.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC76964.1 - 1.9e-10 40.5 0.0 2.9e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EMC76964.1 - 0.00031 20.4 0.1 0.00053 19.6 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 EMC76964.1 - 0.0034 16.8 0.1 0.0058 16.0 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family IFN-gamma PF00714.17 EMC76964.1 - 0.078 12.8 2.1 0.26 11.2 0.0 2.6 2 1 1 3 3 3 0 Interferon gamma FlgM PF04316.13 EMC76964.1 - 0.1 12.9 0.0 0.37 11.2 0.0 1.9 1 0 0 1 1 1 0 Anti-sigma-28 factor, FlgM BTB PF00651.31 EMC76965.1 - 1.7e-24 86.2 0.5 4.5e-24 84.8 0.5 1.8 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 EMC76965.1 - 4.6e-14 52.1 48.4 2.7e-07 30.7 6.2 7.5 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC76965.1 - 1.4e-11 44.2 60.2 0.022 15.6 0.3 7.0 7 0 0 7 7 6 6 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC76965.1 - 1.5e-11 44.1 52.8 0.017 15.6 0.2 6.6 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-met PF12874.7 EMC76965.1 - 2.3e-09 37.3 35.1 0.00028 21.2 0.9 6.6 6 0 0 6 6 6 4 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EMC76965.1 - 1.2e-05 25.1 45.0 0.0083 16.1 1.8 6.7 6 1 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC76965.1 - 0.00023 21.3 44.2 0.0065 16.7 0.4 6.7 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding SCFA_trans PF02667.14 EMC76965.1 - 0.18 10.7 2.5 0.28 10.1 2.5 1.1 1 0 0 1 1 1 0 Short chain fatty acid transporter Hemolysin_N PF12563.8 EMC76965.1 - 0.38 10.3 7.0 0.49 10.0 1.3 2.9 3 0 0 3 3 3 0 Hemolytic toxin N terminal zf-C2H2_2 PF12756.7 EMC76965.1 - 1.7 9.0 36.2 2.9 8.3 2.2 6.7 2 2 4 6 6 6 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_15 PF17032.5 EMC76965.1 - 3 8.6 19.8 8.8 7.2 2.5 3.9 2 1 0 3 3 3 0 zinc-ribbon family zf-C2H2_9 PF16293.5 EMC76965.1 - 3.7 7.5 15.8 2.4 8.1 0.2 4.9 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) zf_UBZ PF18439.1 EMC76965.1 - 3.8 7.2 23.7 2.8 7.6 0.1 5.7 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger zf-AD PF07776.15 EMC76965.1 - 7.4 6.9 17.7 0.65 10.3 0.4 4.5 5 0 0 5 5 4 0 Zinc-finger associated domain (zf-AD) Zn-ribbon_8 PF09723.10 EMC76965.1 - 8.8 6.5 24.7 5.5 7.2 4.4 4.6 3 2 1 4 4 4 0 Zinc ribbon domain SelP_N PF04592.14 EMC76966.1 - 2.2e-43 148.3 17.0 2.5e-43 148.2 17.0 1.0 1 0 0 1 1 1 1 Selenoprotein P, N terminal region Zip PF02535.22 EMC76966.1 - 0.58 9.3 6.1 0.59 9.3 6.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Pox_A_type_inc PF04508.12 EMC76967.1 - 0.011 15.5 0.5 0.011 15.5 0.5 4.0 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat TSC22 PF01166.18 EMC76967.1 - 0.11 12.8 0.9 0.11 12.8 0.9 4.7 2 1 4 6 6 6 0 TSC-22/dip/bun family Peptidase_Prp PF04327.12 EMC76967.1 - 0.13 12.5 0.3 0.13 12.5 0.3 2.6 2 1 0 2 2 2 0 Cysteine protease Prp OmpH PF03938.14 EMC76967.1 - 1.5 9.2 30.9 4.1 7.7 11.4 2.3 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF5320 PF17253.2 EMC76967.1 - 4 8.6 10.0 7.5 7.7 0.2 3.0 2 1 0 3 3 3 0 Family of unknown function (DUF5320) SYCP2_SLD PF18584.1 EMC76967.1 - 5.4 7.3 13.7 0.68 10.2 3.4 2.4 1 1 1 2 2 2 0 Synaptonemal complex 2 Spt16M-like domain Tropomyosin_1 PF12718.7 EMC76967.1 - 6.2 7.0 31.9 2.4 8.3 9.5 2.3 1 1 1 2 2 2 0 Tropomyosin like HIP1_clath_bdg PF16515.5 EMC76967.1 - 7.9 7.2 27.9 27 5.5 10.2 2.9 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 GHBP PF12772.7 EMC76968.1 - 1.1e-131 438.9 7.4 1.3e-131 438.6 7.4 1.1 1 0 0 1 1 1 1 Growth hormone receptor binding EpoR_lig-bind PF09067.10 EMC76968.1 - 6.6e-13 48.8 2.3 6.6e-13 48.8 2.3 2.5 3 0 0 3 3 3 1 Erythropoietin receptor, ligand binding fn3 PF00041.21 EMC76968.1 - 1.7e-06 28.2 0.2 3.7e-06 27.2 0.2 1.6 1 0 0 1 1 1 1 Fibronectin type III domain Nab6_mRNP_bdg PF10567.9 EMC76968.1 - 0.1 12.1 0.1 0.19 11.2 0.1 1.4 1 0 0 1 1 1 0 RNA-recognition motif NinF PF05810.12 EMC76968.1 - 0.13 12.1 0.8 0.34 10.8 0.8 1.7 1 0 0 1 1 1 0 NinF protein IL6Ra-bind PF09240.10 EMC76968.1 - 0.34 11.4 4.2 0.15 12.5 1.0 2.1 2 0 0 2 2 2 0 Interleukin-6 receptor alpha chain, binding HSNSD PF12062.8 EMC76970.1 - 1.5e-243 809.0 0.0 2.1e-243 808.5 0.0 1.2 1 0 0 1 1 1 1 heparan sulfate-N-deacetylase Sulfotransfer_1 PF00685.27 EMC76970.1 - 1.6e-42 145.8 0.0 2.6e-42 145.1 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC76970.1 - 2.8e-09 37.7 0.3 4.3e-05 24.0 0.0 2.4 1 1 1 2 2 2 2 Sulfotransferase family UDPGT PF00201.18 EMC76971.1 - 6.7e-122 407.8 0.0 8.4e-122 407.5 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EMC76971.1 - 2.5e-06 27.6 0.0 4.7e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Imm39 PF15568.6 EMC76971.1 - 0.0071 16.5 0.1 0.013 15.6 0.1 1.4 1 0 0 1 1 1 1 Immunity protein 39 Glyco_trans_1_4 PF13692.6 EMC76971.1 - 0.14 12.6 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferases group 1 Sulfatase PF00884.23 EMC76972.1 - 1.4e-46 159.3 0.1 2.1e-46 158.8 0.1 1.2 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 EMC76972.1 - 2.1e-05 25.2 0.0 5.3e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase DUF4994 PF16385.5 EMC76972.1 - 0.1 12.5 0.0 0.3 11.0 0.0 1.9 1 1 0 1 1 1 0 Domain of unknown function ERK-JNK_inhib PF15002.6 EMC76972.1 - 1.7 8.3 6.6 3.1 7.4 6.6 1.4 1 0 0 1 1 1 0 ERK and JNK pathways, inhibitor Pkinase PF00069.25 EMC76973.1 - 1.6e-68 231.0 0.0 2.6e-68 230.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain CaMKII_AD PF08332.10 EMC76973.1 - 6e-60 201.0 0.0 1.1e-59 200.2 0.0 1.4 1 0 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II association domain Pkinase_Tyr PF07714.17 EMC76973.1 - 1.5e-28 99.8 0.0 3.9e-28 98.4 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase DUF4440 PF14534.6 EMC76973.1 - 1.6e-09 38.1 0.0 3e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_3 PF13474.6 EMC76973.1 - 1.7e-09 38.0 0.0 6.1e-09 36.2 0.0 1.9 2 0 0 2 2 2 1 SnoaL-like domain Pkinase_fungal PF17667.1 EMC76973.1 - 0.0016 17.3 0.0 0.004 16.0 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EMC76973.1 - 0.0017 18.3 0.0 2.4 8.0 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EMC76973.1 - 0.0047 16.3 0.0 0.0089 15.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SnoaL_4 PF13577.6 EMC76973.1 - 0.0051 16.9 0.0 0.0089 16.2 0.0 1.4 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_2 PF12680.7 EMC76973.1 - 0.0099 16.5 0.0 0.022 15.4 0.0 1.6 1 0 0 1 1 1 1 SnoaL-like domain LBP_C PF17386.2 EMC76973.1 - 0.082 12.8 0.2 5 7.1 0.2 2.9 2 1 1 3 3 3 0 Lacto-N-biose phosphorylase C-terminal domain DUF4915 PF16261.5 EMC76973.1 - 0.12 11.6 0.0 0.26 10.5 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4915) RRM_3 PF08777.11 EMC76974.1 - 5.4e-29 100.2 0.1 5.4e-29 100.2 0.1 4.0 5 0 0 5 5 5 2 RNA binding motif La PF05383.17 EMC76974.1 - 1.9e-20 72.7 3.1 2.3e-20 72.4 0.1 2.6 3 0 0 3 3 3 1 La domain RRM_1 PF00076.22 EMC76974.1 - 4.2e-20 71.3 0.1 4e-17 61.8 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HlyD_D4 PF16572.5 EMC76974.1 - 0.11 12.4 0.2 0.31 10.9 0.2 1.7 1 0 0 1 1 1 0 Long alpha hairpin domain of cation efflux system protein, CusB DUF2439 PF10382.9 EMC76975.1 - 3.3e-17 62.6 0.1 9e-17 61.2 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) AAA_12 PF13087.6 EMC76976.1 - 6.1e-53 179.4 0.5 2.7e-52 177.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EMC76976.1 - 3.8e-25 89.2 0.0 1.9e-17 63.9 0.2 2.5 1 1 1 2 2 2 2 AAA domain zf-GRF PF06839.12 EMC76976.1 - 2.1e-13 50.1 0.1 4.6e-13 49.0 0.1 1.6 1 0 0 1 1 1 1 GRF zinc finger Viral_helicase1 PF01443.18 EMC76976.1 - 3.2e-08 33.6 1.3 0.017 14.8 0.1 3.7 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 EMC76976.1 - 0.00091 19.0 0.0 0.012 15.3 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EMC76976.1 - 0.0046 17.3 0.0 0.021 15.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain UvrD_C PF13361.6 EMC76976.1 - 0.012 15.0 0.0 1.7 8.0 0.0 2.6 1 1 1 2 2 2 0 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.6 EMC76976.1 - 0.028 14.3 0.1 0.069 13.0 0.1 1.7 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain FHA PF00498.26 EMC76977.1 - 0.00012 22.3 0.0 0.00017 21.8 0.0 1.2 1 0 0 1 1 1 1 FHA domain DUF4605 PF15378.6 EMC76978.1 - 8.6e-26 89.6 5.6 8.6e-26 89.6 5.6 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4605) Peptidase_M1 PF01433.20 EMC76979.1 - 8.2e-89 296.9 1.9 1.5e-88 296.0 1.9 1.5 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 EMC76979.1 - 7.8e-75 252.3 3.8 7.8e-75 252.3 3.8 1.6 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EMC76979.1 - 1.4e-53 181.9 0.4 3.2e-53 180.7 0.2 1.7 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain DUF1570 PF07607.11 EMC76979.1 - 0.021 15.1 0.1 0.072 13.4 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1570) ELO PF01151.18 EMC76980.1 - 6.4e-68 229.0 23.0 7.5e-68 228.8 23.0 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Ldl_recept_b PF00058.17 EMC76981.1 - 8.3e-48 160.6 8.3 5.1e-10 39.7 0.0 8.2 9 0 0 9 9 9 6 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 EMC76981.1 - 3.6e-37 126.3 146.9 1.7e-08 34.6 6.5 11.5 11 0 0 11 11 11 7 Coagulation Factor Xa inhibitory site cEGF PF12662.7 EMC76981.1 - 8e-34 115.2 77.2 9.2e-06 25.5 2.2 11.3 11 0 0 11 11 11 9 Complement Clr-like EGF-like EGF_CA PF07645.15 EMC76981.1 - 7.9e-22 77.2 139.4 4e-08 33.3 8.8 11.4 10 1 1 11 11 11 5 Calcium-binding EGF domain EGF PF00008.27 EMC76981.1 - 3e-17 62.6 121.3 2.3e-05 24.6 5.0 11.2 11 0 0 11 11 11 7 EGF-like domain EGF_3 PF12947.7 EMC76981.1 - 9.1e-12 45.0 129.1 9.2e-06 25.8 9.4 10.6 10 0 0 10 10 10 6 EGF domain DUF5050 PF16472.5 EMC76981.1 - 1.7e-10 40.6 0.0 9.6e-06 25.0 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF5050) SGL PF08450.12 EMC76981.1 - 3.9e-08 33.2 0.4 0.32 10.6 0.0 4.6 2 1 1 4 4 4 3 SMP-30/Gluconolactonase/LRE-like region hEGF PF12661.7 EMC76981.1 - 0.013 16.1 4.2 0.013 16.1 4.2 10.5 9 0 0 9 9 9 0 Human growth factor-like EGF PLDc PF00614.22 EMC76981.1 - 1.4 9.2 3.9 5.4 7.4 0.0 3.7 5 0 0 5 5 5 0 Phospholipase D Active site motif 7tm_1 PF00001.21 EMC76982.1 - 3.6e-44 151.1 14.3 4.7e-44 150.7 14.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC76982.1 - 5.8e-12 45.5 12.0 7.2e-12 45.2 12.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srt PF10321.9 EMC76982.1 - 0.0096 14.9 17.7 0.028 13.4 17.7 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srt NOT2_3_5 PF04153.18 EMC76982.1 - 0.14 12.3 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 NOT2 / NOT3 / NOT5 family TMEM223 PF14640.6 EMC76982.1 - 0.58 10.3 6.7 0.35 11.0 1.8 2.8 2 1 0 3 3 3 0 Transmembrane protein 223 SafA PF17073.5 EMC76982.1 - 3.6 7.6 6.1 1 9.3 0.2 2.8 3 0 0 3 3 3 0 Two-component-system connector protein Gar1 PF04410.14 EMC76983.1 - 2.2e-39 134.7 0.0 2.7e-39 134.4 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region Trypsin PF00089.26 EMC76984.1 - 3e-59 200.5 1.3 6.7e-59 199.4 1.3 1.6 1 0 0 1 1 1 1 Trypsin Ldl_recept_a PF00057.18 EMC76984.1 - 2.1e-15 56.6 26.3 3.3e-09 36.8 10.4 4.2 4 0 0 4 4 4 2 Low-density lipoprotein receptor domain class A SRCR PF00530.18 EMC76984.1 - 8.6e-11 42.2 3.2 8.6e-11 42.2 3.2 3.3 2 1 1 3 3 3 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 EMC76984.1 - 1.3e-06 28.9 1.6 1.3e-06 28.9 1.6 2.2 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Kazal_2 PF07648.15 EMC76984.1 - 2.7e-06 27.4 5.1 2.7e-06 27.4 5.1 3.2 3 0 0 3 3 3 1 Kazal-type serine protease inhibitor domain Trypsin_2 PF13365.6 EMC76984.1 - 4.6e-06 27.6 0.0 1.4e-05 26.1 0.0 1.7 2 0 0 2 2 2 1 Trypsin-like peptidase domain Peptidase_C14 PF00656.22 EMC76985.1 - 3.1e-54 184.6 0.1 3.7e-54 184.3 0.1 1.1 1 0 0 1 1 1 1 Caspase domain MCU PF04678.13 EMC76986.1 - 3e-68 229.4 2.8 3.8e-68 229.0 2.8 1.1 1 0 0 1 1 1 1 Mitochondrial calcium uniporter Halogen_Hydrol PF10112.9 EMC76986.1 - 0.027 14.5 0.5 0.12 12.4 0.0 1.9 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein FTA4 PF13093.6 EMC76986.1 - 0.52 10.2 4.5 6.1 6.7 0.1 2.1 2 0 0 2 2 2 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Pet100 PF09803.9 EMC76986.1 - 8 7.1 8.6 1.3 9.6 2.1 2.8 3 1 0 3 3 3 0 Pet100 Sec23_trunk PF04811.15 EMC76987.1 - 3.7e-86 288.7 0.1 7.3e-86 287.7 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EMC76987.1 - 1e-26 92.8 3.2 2.9e-26 91.3 3.2 1.9 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EMC76987.1 - 3.1e-21 75.9 0.0 8.4e-21 74.5 0.0 1.8 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EMC76987.1 - 1e-14 54.3 5.3 2.1e-14 53.3 5.3 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EMC76987.1 - 1.1e-08 34.8 0.0 3.1e-08 33.4 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat Sen15 PF09631.10 EMC76987.1 - 0.075 13.3 0.0 0.21 11.9 0.0 1.7 1 0 0 1 1 1 0 Sen15 protein HpaB PF03241.13 EMC76987.1 - 0.17 10.9 0.0 0.34 10.0 0.0 1.4 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase C terminal Ribosomal_L34e PF01199.18 EMC76988.1 - 5.9e-43 145.1 7.3 7.8e-43 144.7 7.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L34e TatD_DNase PF01026.21 EMC76989.1 - 2e-09 37.2 0.0 1.4e-05 24.7 0.0 2.0 1 1 1 2 2 2 2 TatD related DNase Baculo_LEF-11 PF06385.12 EMC76989.1 - 0.02 15.4 0.0 0.025 15.0 0.0 1.3 1 0 0 1 1 1 0 Baculovirus LEF-11 protein CTNNB1_binding PF08347.11 EMC76990.1 - 5.1e-52 177.0 8.2 5.1e-52 177.0 8.2 2.1 2 0 0 2 2 2 1 N-terminal CTNNB1 binding HMG_box PF00505.19 EMC76990.1 - 5.3e-22 78.0 0.7 5.3e-22 78.0 0.7 2.5 3 1 1 4 4 4 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC76990.1 - 6e-09 36.4 0.8 1.8e-08 34.9 0.8 1.8 1 0 0 1 1 1 1 HMG-box domain 3HCDH_N PF02737.18 EMC76991.1 - 7.8e-53 179.0 3.5 1e-52 178.7 3.5 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EMC76991.1 - 1.1e-35 122.1 0.0 2.5e-35 120.9 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain PAP2_C PF14360.6 EMC76992.1 - 6.8e-28 97.0 14.1 6.8e-28 97.0 14.1 2.4 3 0 0 3 3 3 1 PAP2 superfamily C-terminal PAP2 PF01569.21 EMC76992.1 - 1.8e-05 24.5 11.9 1.8e-05 24.5 11.9 2.1 1 1 1 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EMC76992.1 - 0.047 13.4 15.6 0.067 12.9 12.0 2.2 2 1 0 2 2 2 0 PAP2 superfamily APS_kinase PF01583.20 EMC76993.1 - 5.6e-75 250.6 0.0 8.7e-75 249.9 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase ATP-sulfurylase PF01747.17 EMC76993.1 - 3.8e-70 235.7 0.0 5.5e-70 235.1 0.0 1.3 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 EMC76993.1 - 4.1e-50 169.6 0.0 7.5e-50 168.7 0.0 1.5 1 0 0 1 1 1 1 PUA-like domain AAA_33 PF13671.6 EMC76993.1 - 2.2e-07 31.1 0.0 5e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMC76993.1 - 0.00036 21.1 0.0 0.0016 19.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain 6PF2K PF01591.18 EMC76993.1 - 0.032 13.5 0.0 0.063 12.6 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase KTI12 PF08433.10 EMC76993.1 - 0.039 13.4 0.0 0.076 12.5 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Thymidylate_kin PF02223.17 EMC76993.1 - 0.043 13.5 0.0 0.082 12.6 0.0 1.5 1 0 0 1 1 1 0 Thymidylate kinase PEPCK_ATP PF01293.20 EMC76993.1 - 0.043 12.5 0.1 0.59 8.7 0.0 2.0 2 0 0 2 2 2 0 Phosphoenolpyruvate carboxykinase AAA_28 PF13521.6 EMC76993.1 - 0.045 14.0 0.1 0.56 10.4 0.0 2.7 2 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EMC76993.1 - 0.12 11.7 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin RsgA_GTPase PF03193.16 EMC76993.1 - 0.13 12.2 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase PRK PF00485.18 EMC76993.1 - 0.13 12.0 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Dickkopf_N PF04706.12 EMC76994.1 - 7.4e-17 61.6 40.4 3.3e-16 59.5 20.1 3.2 2 1 1 3 3 3 2 Dickkopf N-terminal cysteine-rich region DUF4501 PF14946.6 EMC76994.1 - 0.037 14.1 6.0 0.087 12.9 6.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4501) Sperm_Ag_HE2 PF05324.13 EMC76994.1 - 0.18 12.3 0.3 0.49 10.9 0.0 1.9 2 0 0 2 2 2 0 Sperm antigen HE2 AIG1 PF04548.16 EMC76995.1 - 1.4e-26 93.2 0.0 2e-26 92.6 0.0 1.2 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 EMC76995.1 - 6.5e-05 23.0 0.0 0.00011 22.2 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 EMC76995.1 - 0.0065 15.8 0.0 0.0092 15.3 0.0 1.2 1 0 0 1 1 1 1 Septin FtsK_SpoIIIE PF01580.18 EMC76995.1 - 0.038 13.3 0.1 0.081 12.3 0.1 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family tRNA_bind PF01588.20 EMC76996.1 - 2.5e-31 107.7 1.9 3.1e-31 107.3 0.1 2.0 2 1 0 2 2 2 1 Putative tRNA binding domain SR-25 PF10500.9 EMC76996.1 - 0.37 10.4 11.4 0.63 9.6 11.4 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ribosomal_60s PF00428.19 EMC76996.1 - 0.7 10.5 8.1 2.7 8.7 8.1 2.0 1 1 0 1 1 1 0 60s Acidic ribosomal protein PV-1 PF06637.11 EMC76996.1 - 0.75 8.5 10.2 1 8.1 10.2 1.2 1 0 0 1 1 1 0 PV-1 protein (PLVAP) NUDE_C PF04880.13 EMC76996.1 - 1.5 9.3 10.1 1.3 9.4 5.6 2.0 1 1 1 2 2 2 0 NUDE protein, C-terminal conserved region RabGAP-TBC PF00566.18 EMC76997.1 - 8.5e-43 146.5 0.1 1.3e-42 145.9 0.1 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Pkinase PF00069.25 EMC76997.1 - 8.8e-34 117.1 0.0 1.3e-33 116.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC76997.1 - 3.2e-23 82.3 0.0 5.5e-23 81.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Rhodanese PF00581.20 EMC76997.1 - 4.2e-14 53.0 0.0 7.9e-14 52.1 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Kinase-like PF14531.6 EMC76997.1 - 0.00012 21.5 0.0 0.0002 20.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like EGF_CA PF07645.15 EMC76998.1 - 7e-23 80.6 36.4 1.8e-10 40.9 3.7 5.7 4 2 1 5 5 5 3 Calcium-binding EGF domain MAM PF00629.23 EMC76998.1 - 7.6e-21 74.7 0.0 1.7e-20 73.5 0.0 1.6 1 1 0 1 1 1 1 MAM domain, meprin/A5/mu cEGF PF12662.7 EMC76998.1 - 7.2e-18 64.2 47.8 1.6e-07 31.1 0.9 6.0 6 0 0 6 6 6 5 Complement Clr-like EGF-like FXa_inhibition PF14670.6 EMC76998.1 - 1.3e-09 38.2 77.5 7.2e-06 26.2 7.0 5.6 4 1 1 5 5 5 4 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 EMC76998.1 - 3.3e-05 24.0 20.3 0.00019 21.5 12.9 6.0 4 1 1 5 5 5 3 EGF domain EGF PF00008.27 EMC76998.1 - 5.5e-05 23.4 77.6 0.09 13.1 9.1 6.4 5 1 1 6 6 6 4 EGF-like domain C_tripleX PF02363.19 EMC76998.1 - 0.0096 16.1 6.8 0.0096 16.1 6.8 2.9 2 0 0 2 2 2 1 Cysteine rich repeat EGF_2 PF07974.13 EMC76998.1 - 0.029 14.7 15.9 0.029 14.7 15.9 6.3 5 1 0 5 5 5 0 EGF-like domain EGF_MSP1_1 PF12946.7 EMC76998.1 - 0.031 14.3 41.5 0.077 13.1 8.6 5.1 3 1 2 5 5 5 0 MSP1 EGF domain 1 Methyltransf_32 PF13679.6 EMC76999.1 - 1.9e-10 41.0 3.7 4.1e-09 36.6 3.7 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC76999.1 - 6.3e-07 29.3 0.0 1.2e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain TRM13 PF05206.14 EMC76999.1 - 1.8e-06 27.7 1.2 0.052 13.1 0.0 2.8 1 1 1 2 2 2 2 Methyltransferase TRM13 GST_C_2 PF13410.6 EMC76999.1 - 2.6e-05 24.1 0.0 0.036 14.1 0.0 2.7 2 0 0 2 2 2 2 Glutathione S-transferase, C-terminal domain GidB PF02527.15 EMC76999.1 - 0.00016 21.1 0.0 0.00035 20.0 0.0 1.5 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_4 PF02390.17 EMC76999.1 - 0.00088 18.8 0.0 0.0015 18.1 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 EMC76999.1 - 0.0027 17.3 0.0 0.005 16.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EMC76999.1 - 0.0073 17.0 0.1 0.017 15.8 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMC76999.1 - 0.027 13.8 0.0 0.051 12.9 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family GST_C_3 PF14497.6 EMC76999.1 - 0.035 14.3 0.0 0.1 12.8 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Methyltransf_16 PF10294.9 EMC76999.1 - 0.075 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_18 PF12847.7 EMC76999.1 - 0.18 11.8 0.0 0.3 11.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DUF3306 PF11748.8 EMC76999.1 - 0.38 11.6 1.4 0.52 11.2 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) PHD PF00628.29 EMC77000.1 - 1.3e-09 37.8 9.7 2.1e-09 37.1 9.7 1.4 1 0 0 1 1 1 1 PHD-finger C1_1 PF00130.22 EMC77000.1 - 5.7e-05 22.9 2.9 5.7e-05 22.9 2.9 1.9 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-PHD-like PF15446.6 EMC77000.1 - 0.0018 17.9 2.5 0.0018 17.9 2.5 1.8 2 0 0 2 2 2 1 PHD/FYVE-zinc-finger like domain PHD_2 PF13831.6 EMC77000.1 - 0.0028 17.2 5.4 0.0061 16.1 5.4 1.6 1 0 0 1 1 1 1 PHD-finger zf-RING_9 PF13901.6 EMC77000.1 - 0.0042 17.1 5.7 0.0079 16.2 5.7 1.4 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon Prok-RING_1 PF14446.6 EMC77000.1 - 0.013 15.4 3.8 0.013 15.4 3.8 1.5 2 0 0 2 2 1 0 Prokaryotic RING finger family 1 PHD_4 PF16866.5 EMC77000.1 - 0.02 15.0 9.8 0.069 13.2 9.8 2.0 1 1 0 1 1 1 0 PHD-finger zf-4CXXC_R1 PF10497.9 EMC77000.1 - 0.14 12.4 4.8 0.29 11.4 4.8 1.5 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 FYVE_2 PF02318.16 EMC77000.1 - 0.18 12.0 5.7 0.35 11.1 5.7 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger zinc_ribbon_15 PF17032.5 EMC77000.1 - 0.28 12.0 3.6 0.6 10.9 3.6 1.5 1 0 0 1 1 1 0 zinc-ribbon family Cytochrom_c3_2 PF14537.6 EMC77000.1 - 0.54 10.8 8.9 8.7 6.9 8.9 2.6 1 1 0 1 1 1 0 Cytochrome c3 Zf_RING PF16744.5 EMC77000.1 - 9.9 6.4 9.7 36 4.6 9.6 2.0 1 1 0 1 1 1 0 KIAA1045 RING finger RhoGEF PF00621.20 EMC77001.1 - 6.8e-15 55.8 0.1 6.8e-15 55.8 0.1 2.5 2 1 1 3 3 3 1 RhoGEF domain BAR PF03114.18 EMC77001.1 - 3.7e-14 53.0 5.9 3.7e-14 53.0 5.9 1.9 2 1 0 2 2 2 1 BAR domain SH3_2 PF07653.17 EMC77001.1 - 4.7e-12 45.4 0.0 5.3e-05 22.8 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_9 PF14604.6 EMC77001.1 - 9.4e-10 38.2 0.1 2.3e-09 36.9 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EMC77001.1 - 1.6e-08 34.0 0.4 5.6e-08 32.3 0.1 2.1 2 0 0 2 2 2 1 SH3 domain SH3_3 PF08239.11 EMC77001.1 - 0.052 13.8 0.5 0.65 10.3 0.1 2.3 2 0 0 2 2 2 0 Bacterial SH3 domain RhoGEF PF00621.20 EMC77002.1 - 5.3e-19 69.2 0.7 7.2e-19 68.7 0.7 1.2 1 0 0 1 1 1 1 RhoGEF domain Pyrophosphatase PF00719.19 EMC77003.1 - 3.5e-58 195.9 0.7 4.2e-58 195.7 0.7 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase zf-RING_12 PF17976.1 EMC77003.1 - 0.074 13.3 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Tet_JBP PF12851.7 EMC77004.1 - 9.9e-136 452.5 4.5 9.9e-136 452.5 4.5 2.6 2 1 0 2 2 2 1 Oxygenase domain of the 2OGFeDO superfamily 7tm_1 PF00001.21 EMC77006.1 - 6.3e-58 196.2 19.2 8.5e-58 195.7 19.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC77006.1 - 5.7e-11 42.3 19.5 7.6e-11 41.9 19.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC77006.1 - 5.3e-05 23.1 19.1 0.0003 20.6 19.1 2.0 1 1 0 1 1 1 1 Olfactory receptor PsbX PF06596.11 EMC77006.1 - 2.9 8.0 9.3 0.13 12.3 1.8 2.7 3 0 0 3 3 3 0 Photosystem II reaction centre X protein (PsbX) Radial_spoke PF04712.12 EMC77007.1 - 5.2e-203 675.4 6.9 5.2e-203 675.4 6.9 2.0 1 1 1 2 2 2 1 Radial spokehead-like protein TBPIP PF07106.13 EMC77007.1 - 0.0011 18.9 0.0 0.0022 17.9 0.0 1.5 1 0 0 1 1 1 1 TBPIP/Hop2 winged helix domain RNA_pol_Rpc4 PF05132.14 EMC77007.1 - 4.3 7.8 9.9 4.7 7.6 0.1 3.2 3 0 0 3 3 3 0 RNA polymerase III RPC4 Kinesin PF00225.23 EMC77008.1 - 1.7e-109 365.8 0.1 1.7e-109 365.8 0.1 4.0 2 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EMC77008.1 - 1.5e-26 93.2 0.0 1.5e-26 93.2 0.0 3.9 3 2 1 4 4 4 1 Microtubule binding ZapB PF06005.12 EMC77009.1 - 0.0081 16.6 7.0 0.0081 16.6 7.0 2.4 2 0 0 2 2 2 1 Cell division protein ZapB PRKG1_interact PF15898.5 EMC77009.1 - 0.071 14.0 17.8 0.23 12.4 9.0 3.2 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain XRCC4 PF06632.12 EMC77009.1 - 0.11 11.3 9.4 0.022 13.6 2.3 2.3 2 0 0 2 2 2 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 V_ATPase_I PF01496.19 EMC77009.1 - 1.5 6.7 4.0 1.6 6.5 4.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 EMC77009.1 - 2 7.7 4.9 2.6 7.3 4.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DivIC PF04977.15 EMC77009.1 - 2.3 8.1 13.1 0.54 10.1 2.0 2.6 2 0 0 2 2 2 0 Septum formation initiator CENP-H PF05837.12 EMC77009.1 - 4.9 7.6 12.5 1.3 9.4 3.2 2.3 2 0 0 2 2 2 0 Centromere protein H (CENP-H) TMPIT PF07851.13 EMC77009.1 - 5.9 6.0 10.2 3 7.0 2.1 2.0 2 0 0 2 2 2 0 TMPIT-like protein DUF724 PF05266.14 EMC77009.1 - 7.3 6.4 12.4 0.39 10.5 3.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Na_H_Exchanger PF00999.21 EMC77010.1 - 6.4e-27 94.3 37.6 1e-26 93.6 37.6 1.3 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family MitoNEET_N PF10660.9 EMC77011.1 - 3.1e-18 65.5 0.1 4.2e-18 65.1 0.1 1.2 1 0 0 1 1 1 1 Iron-containing outer mitochondrial membrane protein N-terminus zf-CDGSH PF09360.10 EMC77011.1 - 6e-10 39.2 0.2 1e-09 38.4 0.2 1.4 1 0 0 1 1 1 1 Iron-binding zinc finger CDGSH type UQ_con PF00179.26 EMC77012.1 - 1.9e-47 160.4 0.1 2.2e-47 160.2 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EMC77012.1 - 0.012 15.9 0.0 0.02 15.2 0.0 1.4 1 0 0 1 1 1 0 RWD domain Prok-E2_B PF14461.6 EMC77012.1 - 0.022 14.4 0.0 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B UEV PF05743.13 EMC77012.1 - 0.063 13.1 0.1 0.1 12.5 0.1 1.3 1 1 0 1 1 1 0 UEV domain Ig_mannosidase PF17753.1 EMC77013.1 - 4.2e-21 74.5 0.1 1.4e-20 72.8 0.1 2.0 1 0 0 1 1 1 1 Ig-fold domain Mannosidase_ig PF17786.1 EMC77013.1 - 1.1e-11 45.2 0.3 2.9e-11 43.8 0.0 1.9 2 0 0 2 2 2 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2_C PF02836.17 EMC77013.1 - 3.2e-08 33.0 1.5 1.6e-07 30.8 1.5 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 EMC77013.1 - 3.1e-05 23.9 0.4 7.2e-05 22.7 0.4 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Lipocalin PF00061.23 EMC77013.1 - 0.33 11.2 1.6 0.97 9.6 0.3 2.2 2 0 0 2 2 2 0 Lipocalin / cytosolic fatty-acid binding protein family Zip PF02535.22 EMC77014.1 - 1.4e-68 231.6 5.1 1.7e-68 231.3 5.1 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter DUF4271 PF14093.6 EMC77014.1 - 0.0025 17.8 2.1 0.0025 17.8 2.1 2.6 2 1 0 2 2 2 1 Domain of unknown function (DUF4271) DUF5638 PF18688.1 EMC77015.1 - 0.08 13.3 0.2 0.13 12.6 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5638) FUSC PF04632.12 EMC77015.1 - 0.54 8.7 0.8 0.62 8.5 0.8 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family TIR_3 PF18567.1 EMC77016.1 - 2.9e-47 160.0 0.7 6.1e-47 158.9 0.7 1.6 1 0 0 1 1 1 1 Toll/interleukin-1 receptor domain DBB PF14545.6 EMC77016.1 - 3.2e-40 137.3 0.0 7.4e-40 136.1 0.0 1.6 2 0 0 2 2 2 1 Dof, BCAP, and BANK (DBB) motif, Ank_2 PF12796.7 EMC77016.1 - 0.0021 18.6 0.0 0.0046 17.5 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EMC77016.1 - 0.23 11.9 0.8 0.89 10.1 0.1 2.4 2 0 0 2 2 2 0 Ankyrin repeat Metallophos PF00149.28 EMC77017.1 - 3.3e-38 132.2 0.0 5.3e-38 131.6 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Endomucin PF07010.12 EMC77018.1 - 1.2e-31 110.7 0.0 1.4e-31 110.5 0.0 1.0 1 0 0 1 1 1 1 Endomucin Pilin_N PF07790.11 EMC77018.1 - 0.035 15.0 0.0 0.039 14.9 0.0 1.1 1 0 0 1 1 1 0 Archaeal Type IV pilin, N-terminal Sel1 PF08238.12 EMC77019.1 - 8e-08 32.7 0.3 8e-08 32.7 0.3 2.2 2 0 0 2 2 2 1 Sel1 repeat Histone PF00125.24 EMC77020.1 - 1.7e-19 70.5 0.0 2.2e-19 70.1 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EMC77020.1 - 2.5e-13 49.5 0.5 5.7e-13 48.4 0.5 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 EMC77020.1 - 0.0046 17.2 0.0 0.0074 16.6 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF1977 PF09320.11 EMC77021.1 - 6.3e-27 93.9 3.7 1.1e-26 93.1 3.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 EMC77021.1 - 9.5e-27 92.9 0.4 2.7e-26 91.5 0.4 1.8 1 0 0 1 1 1 1 DnaJ domain ECSCR PF15820.5 EMC77021.1 - 1.7 8.5 3.5 6.4 6.7 0.1 2.3 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator MAPKK1_Int PF08923.10 EMC77022.1 - 3.1e-46 156.0 0.0 3.5e-46 155.9 0.0 1.0 1 0 0 1 1 1 1 Mitogen-activated protein kinase kinase 1 interacting SH2 PF00017.24 EMC77023.1 - 1.1e-19 70.2 0.4 2e-19 69.4 0.4 1.4 1 0 0 1 1 1 1 SH2 domain PH PF00169.29 EMC77023.1 - 7.7e-19 68.2 0.6 1.3e-18 67.4 0.6 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EMC77023.1 - 0.00035 20.9 1.5 0.0017 18.7 1.5 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain Vitellogenin_N PF01347.22 EMC77024.1 - 7.6e-69 232.7 9.7 9.1e-69 232.5 9.7 1.1 1 0 0 1 1 1 1 Lipoprotein amino terminal region HEAT_2 PF13646.6 EMC77024.1 - 0.00053 20.3 0.5 0.11 12.9 0.2 2.6 2 0 0 2 2 2 2 HEAT repeats EF-G-binding_N PF07299.11 EMC77024.1 - 0.23 12.0 2.4 11 6.7 0.3 3.3 3 0 0 3 3 3 0 Elongation factor G-binding protein, N-terminal HTH_9 PF08221.11 EMC77024.1 - 1.8 8.7 5.0 12 6.0 0.1 3.8 4 0 0 4 4 4 0 RNA polymerase III subunit RPC82 helix-turn-helix domain tRNA_m1G_MT PF01746.21 EMC77025.1 - 6.6e-29 101.0 0.4 1.1e-28 100.3 0.4 1.4 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase NARP1 PF12569.8 EMC77025.1 - 0.14 11.1 9.1 0.2 10.5 9.1 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 ADH_N PF08240.12 EMC77026.1 - 1.6e-25 89.1 1.3 3.5e-25 88.0 1.3 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMC77026.1 - 4e-24 85.1 0.3 7.3e-24 84.2 0.3 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.14 EMC77026.1 - 0.034 13.7 0.2 0.052 13.1 0.2 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PDEase_I PF00233.19 EMC77027.1 - 1.6e-78 263.7 4.7 1.6e-78 263.7 4.7 1.9 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.26 EMC77027.1 - 6.7e-28 98.0 0.0 8.5e-13 49.1 0.0 2.5 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.6 EMC77027.1 - 4.3e-10 40.0 0.0 0.00031 21.0 0.0 2.4 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.6 EMC77027.1 - 3.7e-07 30.5 0.0 0.00081 19.7 0.0 2.8 2 1 0 2 2 2 2 GAF domain SpoVT_C PF15714.5 EMC77027.1 - 0.00022 21.3 0.3 0.03 14.4 0.0 3.3 3 0 0 3 3 3 1 Stage V sporulation protein T C-terminal, transcription factor SANT_DAMP1_like PF16282.5 EMC77027.1 - 0.095 12.9 1.2 0.52 10.5 0.1 2.7 2 0 0 2 2 2 0 SANT/Myb-like domain of DAMP1 DUF4316 PF14195.6 EMC77027.1 - 0.11 12.3 0.1 0.25 11.1 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4316) Lipocalin PF00061.23 EMC77028.1 - 4e-18 66.0 0.0 5.1e-18 65.7 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_2 PF08212.12 EMC77028.1 - 8.2e-10 38.8 0.0 1.2e-09 38.2 0.0 1.3 1 0 0 1 1 1 1 Lipocalin-like domain Triabin PF03973.13 EMC77028.1 - 1.3e-05 25.1 0.1 0.001 19.0 0.0 2.2 2 0 0 2 2 2 2 Triabin Glyco_hydro_39 PF01229.17 EMC77029.1 - 1.8e-154 514.9 0.0 2.3e-154 514.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 39 Sulfate_transp PF00916.20 EMC77030.1 - 4.2e-122 407.6 23.2 5.9e-122 407.1 23.2 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EMC77030.1 - 1.9e-25 88.8 0.1 5.4e-25 87.3 0.0 1.8 2 0 0 2 2 2 1 STAS domain Viral_cys_rich PF08008.12 EMC77030.1 - 0.086 12.9 0.7 0.29 11.2 0.1 2.2 3 0 0 3 3 3 0 Viral cysteine rich Neur_chan_memb PF02932.16 EMC77031.1 - 1e-90 304.0 6.7 1.4e-90 303.6 6.7 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 EMC77031.1 - 8.6e-76 254.2 4.1 1.5e-75 253.4 4.1 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF1980 PF09323.10 EMC77031.1 - 0.023 14.6 0.5 0.049 13.5 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Neur_chan_LBD PF02931.23 EMC77032.1 - 4.6e-75 251.8 0.3 7.6e-75 251.0 0.3 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC77032.1 - 1.1e-64 218.8 16.0 2.8e-49 168.3 12.1 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region PepSY_TM PF03929.16 EMC77032.1 - 0.31 10.7 5.1 0.054 13.2 1.4 1.6 2 0 0 2 2 2 0 PepSY-associated TM region THAP PF05485.12 EMC77033.1 - 3.3e-16 60.0 8.0 3.3e-16 60.0 8.0 2.0 2 1 0 2 2 2 1 THAP domain Cep57_CLD PF14073.6 EMC77033.1 - 1.8e-05 24.9 2.1 2.8e-05 24.2 2.1 1.2 1 0 0 1 1 1 1 Centrosome localisation domain of Cep57 ATG16 PF08614.11 EMC77033.1 - 0.0015 18.8 0.0 0.0018 18.6 0.0 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) PI3K_P85_iSH2 PF16454.5 EMC77033.1 - 0.0015 18.1 7.5 0.0022 17.6 7.5 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain ADIP PF11559.8 EMC77033.1 - 0.0021 18.1 9.0 0.0032 17.6 9.0 1.2 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding Macoilin PF09726.9 EMC77033.1 - 0.0029 16.3 2.8 0.004 15.8 2.8 1.1 1 0 0 1 1 1 1 Macoilin family Ax_dynein_light PF10211.9 EMC77033.1 - 0.0063 16.5 6.3 0.012 15.5 6.3 1.4 1 0 0 1 1 1 1 Axonemal dynein light chain GrpE PF01025.19 EMC77033.1 - 0.015 15.0 5.3 0.023 14.3 5.3 1.2 1 0 0 1 1 1 0 GrpE DUF4391 PF14335.6 EMC77033.1 - 0.015 15.0 2.4 0.023 14.4 2.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) MPS2 PF17060.5 EMC77033.1 - 0.015 14.6 1.8 0.02 14.1 1.8 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 DUF16 PF01519.16 EMC77033.1 - 0.019 15.4 4.3 0.037 14.5 4.3 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF16 Tropomyosin PF00261.20 EMC77033.1 - 0.026 13.9 6.4 0.035 13.5 6.4 1.2 1 0 0 1 1 1 0 Tropomyosin DUF573 PF04504.14 EMC77033.1 - 0.027 15.1 1.1 0.068 13.8 1.1 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF573 DUF4140 PF13600.6 EMC77033.1 - 0.079 13.4 0.6 0.12 12.8 0.6 1.3 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Sec2p PF06428.11 EMC77033.1 - 0.11 12.5 4.3 0.17 11.9 4.3 1.2 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p HGD-D PF06050.13 EMC77033.1 - 0.11 12.2 0.3 0.18 11.5 0.3 1.3 1 0 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component FlaC_arch PF05377.11 EMC77033.1 - 0.18 12.2 2.9 0.27 11.6 2.9 1.3 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF4407 PF14362.6 EMC77033.1 - 0.19 11.1 1.5 0.26 10.6 1.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DivIC PF04977.15 EMC77033.1 - 0.21 11.4 7.7 0.36 10.6 7.7 1.3 1 0 0 1 1 1 0 Septum formation initiator YPEB PF14620.6 EMC77033.1 - 0.24 10.7 2.9 0.34 10.2 2.9 1.1 1 0 0 1 1 1 0 YpeB sporulation FliD_C PF07195.12 EMC77033.1 - 0.35 10.2 1.3 0.49 9.8 1.3 1.1 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus PRIMA1 PF16101.5 EMC77033.1 - 0.5 10.4 15.1 1.3 9.1 15.1 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 ABC_tran_Xtn PF12848.7 EMC77033.1 - 0.82 9.7 9.4 1.5 8.9 9.4 1.4 1 0 0 1 1 1 0 ABC transporter Spc7 PF08317.11 EMC77033.1 - 1 8.2 8.1 1.4 7.7 8.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein XhlA PF10779.9 EMC77033.1 - 2.9 8.2 4.4 4.5 7.6 4.4 1.2 1 0 0 1 1 1 0 Haemolysin XhlA USP8_interact PF08941.10 EMC77033.1 - 2.9 7.7 6.1 5.2 6.8 6.1 1.4 1 0 0 1 1 1 0 USP8 interacting DUF1232 PF06803.12 EMC77034.1 - 2.3e-09 36.9 9.4 2.3e-09 36.9 9.4 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1232) zf-RING_UBOX PF13445.6 EMC77034.1 - 6.1e-09 35.8 5.7 1e-08 35.1 2.8 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EMC77034.1 - 2.1e-08 33.9 4.1 3.7e-08 33.1 4.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMC77034.1 - 2.2e-08 33.8 2.8 3.2e-08 33.3 2.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMC77034.1 - 6.8e-08 32.5 5.0 1.7e-07 31.3 5.0 1.7 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EMC77034.1 - 1.3e-06 28.6 6.7 2.2e-06 27.9 6.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC77034.1 - 2.4e-06 27.3 5.3 5.9e-06 26.0 5.3 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC77034.1 - 1.2e-05 25.1 3.7 3.1e-05 23.7 3.8 1.7 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EMC77034.1 - 1.5e-05 24.8 4.7 3.1e-05 23.9 4.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Cys_rich_CPXG PF14255.6 EMC77034.1 - 0.0041 17.0 0.6 2.2 8.2 0.2 2.4 2 0 0 2 2 2 2 Cysteine-rich CPXCG zf-Nse PF11789.8 EMC77034.1 - 0.0076 16.1 1.0 0.014 15.2 1.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit DpnI_C PF17726.1 EMC77034.1 - 0.022 14.9 0.1 0.043 13.9 0.1 1.5 1 0 0 1 1 1 0 Dam-replacing HTH domain zf-ANAPC11 PF12861.7 EMC77034.1 - 0.044 13.8 2.0 0.084 12.9 2.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 EMC77034.1 - 0.13 12.5 1.2 0.24 11.6 1.2 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-rbx1 PF12678.7 EMC77034.1 - 0.71 10.2 5.9 1.8 8.9 5.9 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger domain TerY_C PF15616.6 EMC77034.1 - 1.8 8.7 5.0 6.2 7.0 5.0 1.8 1 1 0 1 1 1 0 TerY-C metal binding domain zf-WRNIP1_ubi PF18279.1 EMC77034.1 - 2.1 9.2 5.2 30 5.5 0.2 2.7 2 0 0 2 2 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain HOOK PF05622.12 EMC77035.1 - 7.6e-205 682.1 42.7 8.5e-205 682.0 42.7 1.0 1 0 0 1 1 1 1 HOOK protein KASH_CCD PF14662.6 EMC77035.1 - 3.5e-06 27.0 55.5 0.0014 18.5 6.2 4.3 1 1 2 3 3 3 2 Coiled-coil region of CCDC155 or KASH bZIP_1 PF00170.21 EMC77035.1 - 7.4e-06 26.0 47.9 0.085 13.0 2.4 6.2 3 2 3 6 6 6 3 bZIP transcription factor HALZ PF02183.18 EMC77035.1 - 0.0009 19.4 3.3 0.0009 19.4 3.3 5.8 4 1 1 5 5 5 2 Homeobox associated leucine zipper PspA_IM30 PF04012.12 EMC77035.1 - 0.0019 17.8 38.1 0.082 12.5 18.3 2.8 1 1 2 3 3 3 2 PspA/IM30 family Mod_r PF07200.13 EMC77035.1 - 0.002 18.3 19.8 0.002 18.3 19.8 4.1 1 1 3 4 4 3 1 Modifier of rudimentary (Mod(r)) protein ATG16 PF08614.11 EMC77035.1 - 0.0029 17.8 53.0 0.066 13.4 5.2 3.5 1 1 1 3 3 3 2 Autophagy protein 16 (ATG16) BLOC1_2 PF10046.9 EMC77035.1 - 0.0048 17.2 9.9 0.0048 17.2 9.9 4.9 3 1 1 5 5 5 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 MAD PF05557.13 EMC77035.1 - 0.0083 14.5 49.8 0.11 10.8 36.2 2.1 1 1 1 2 2 2 2 Mitotic checkpoint protein GAS PF13851.6 EMC77035.1 - 0.022 14.1 54.7 0.45 9.8 8.3 4.3 1 1 3 4 4 4 0 Growth-arrest specific micro-tubule binding Fez1 PF06818.15 EMC77035.1 - 0.055 13.9 49.2 1.5 9.2 17.7 3.2 1 1 1 2 2 2 0 Fez1 YabA PF06156.13 EMC77035.1 - 0.06 14.0 46.2 0.13 12.9 3.7 5.5 2 1 4 6 6 5 0 Initiation control protein YabA Laminin_II PF06009.12 EMC77035.1 - 0.17 11.9 30.8 0.14 12.2 4.4 3.8 1 1 0 3 3 3 0 Laminin Domain II Seryl_tRNA_N PF02403.22 EMC77035.1 - 0.19 12.0 38.4 0.84 9.9 8.7 4.0 2 1 2 4 4 4 0 Seryl-tRNA synthetase N-terminal domain TPR_MLP1_2 PF07926.12 EMC77035.1 - 0.25 11.4 59.2 0.07 13.2 23.0 4.4 2 2 1 3 3 3 0 TPR/MLP1/MLP2-like protein SHE3 PF17078.5 EMC77035.1 - 0.43 10.2 44.6 0.1 12.3 23.1 3.2 1 1 2 3 3 3 0 SWI5-dependent HO expression protein 3 DUF3450 PF11932.8 EMC77035.1 - 0.53 9.5 45.6 0.85 8.9 9.6 4.3 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) Taxilin PF09728.9 EMC77035.1 - 0.8 8.8 53.6 0.035 13.3 16.1 4.1 1 1 1 3 3 3 0 Myosin-like coiled-coil protein DUF948 PF06103.11 EMC77035.1 - 0.89 9.9 15.1 2 8.8 1.2 4.2 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF4988 PF16378.5 EMC77035.1 - 0.93 9.1 12.5 5.7 6.6 0.6 4.3 3 1 1 4 4 4 0 Domain of unknown function Rootletin PF15035.6 EMC77035.1 - 1 9.3 54.5 0.15 12.1 22.2 3.1 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion NPV_P10 PF05531.12 EMC77035.1 - 2.3 8.7 25.5 2 8.9 0.0 6.6 3 1 2 6 6 6 0 Nucleopolyhedrovirus P10 protein APG6_N PF17675.1 EMC77035.1 - 3.7 8.1 63.6 1.8 9.1 10.1 3.7 1 1 3 4 4 4 0 Apg6 coiled-coil region Spc7 PF08317.11 EMC77035.1 - 4.3 6.1 56.3 0.41 9.5 21.3 3.1 1 1 2 3 3 3 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 EMC77035.1 - 4.4 7.3 59.3 0.15 12.1 19.3 3.8 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Shugoshin_N PF07558.11 EMC77035.1 - 6.1 6.8 13.8 0.69 9.8 1.6 4.1 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region CALCOCO1 PF07888.11 EMC77035.1 - 7.3 5.3 51.3 0.65 8.8 36.0 2.1 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Jnk-SapK_ap_N PF09744.9 EMC77035.1 - 7.6 6.7 56.1 3.4 7.9 5.3 3.6 2 1 2 4 4 4 0 JNK_SAPK-associated protein-1 CEP63 PF17045.5 EMC77035.1 - 7.8 6.3 48.2 74 3.1 25.0 2.5 1 1 1 2 2 2 0 Centrosomal protein of 63 kDa HMMR_C PF15908.5 EMC77035.1 - 8.6 6.6 28.4 0.1 12.9 1.0 4.1 2 1 1 3 3 3 0 Hyaluronan mediated motility receptor C-terminal Collagen PF01391.18 EMC77036.1 - 6e-21 74.0 75.3 3.2e-08 33.2 11.0 5.2 1 1 1 2 2 2 1 Collagen triple helix repeat (20 copies) MFS_1 PF07690.16 EMC77037.1 - 4.3e-38 131.2 51.6 3.4e-37 128.2 31.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMC77037.1 - 3.1e-13 49.4 24.2 5e-13 48.7 24.2 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter OATP PF03137.20 EMC77037.1 - 4.3e-13 48.4 19.7 4.8e-05 21.9 10.1 4.3 1 1 2 3 3 3 3 Organic Anion Transporter Polypeptide (OATP) family MFS_2 PF13347.6 EMC77037.1 - 5.2e-06 25.3 4.1 5.2e-06 25.3 4.1 2.3 2 1 0 2 2 2 1 MFS/sugar transport protein UQ_con PF00179.26 EMC77038.1 - 8.8e-50 168.0 0.0 9.8e-50 167.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EMC77038.1 - 0.11 12.8 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 RWD domain Ank_2 PF12796.7 EMC77039.1 - 5.6e-81 267.2 24.6 2e-12 47.5 2.5 12.0 4 3 9 14 14 14 14 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC77039.1 - 8.6e-69 219.3 29.8 5.3e-05 23.3 0.0 20.8 22 0 0 22 22 22 16 Ankyrin repeat Ank_4 PF13637.6 EMC77039.1 - 4.2e-64 212.2 23.6 2e-06 28.2 0.4 16.9 7 5 10 18 18 18 12 Ankyrin repeats (many copies) Ank PF00023.30 EMC77039.1 - 3e-63 207.7 38.6 1.2e-08 35.0 0.0 20.3 21 1 0 21 21 21 11 Ankyrin repeat Ank_5 PF13857.6 EMC77039.1 - 4.9e-59 195.6 28.7 3.4e-08 33.6 0.0 15.2 10 3 3 14 14 14 10 Ankyrin repeats (many copies) FYVE PF01363.21 EMC77039.1 - 6e-16 58.3 10.5 1.5e-15 57.0 10.5 1.7 1 0 0 1 1 1 1 FYVE zinc finger BTB PF00651.31 EMC77039.1 - 1.5e-15 57.3 0.2 5.6e-15 55.5 0.2 2.0 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 EMC77039.1 - 0.018 15.1 2.5 0.034 14.2 0.3 2.5 2 1 1 3 3 3 0 BTB And C-terminal Kelch DASH_Hsk3 PF08227.11 EMC77039.1 - 0.11 12.9 0.8 0.57 10.6 0.8 2.3 1 0 0 1 1 1 0 DASH complex subunit Hsk3 like FYVE_2 PF02318.16 EMC77039.1 - 1.3 9.2 11.9 0.37 11.0 7.4 2.2 2 0 0 2 2 2 0 FYVE-type zinc finger ZZ PF00569.17 EMC77040.1 - 1.7e-14 53.3 24.7 1.9e-08 34.0 6.8 2.9 3 0 0 3 3 3 2 Zinc finger, ZZ type ANAPC10 PF03256.16 EMC77040.1 - 1.5e-13 50.8 0.4 3e-13 49.8 0.4 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 EMC77040.1 - 9.7e-06 25.7 0.1 2.1e-05 24.6 0.1 1.5 1 0 0 1 1 1 1 F5/8 type C domain EF-hand_6 PF13405.6 EMC77040.1 - 0.012 15.5 0.0 0.061 13.3 0.0 2.3 1 0 0 1 1 1 0 EF-hand domain EF-hand_1 PF00036.32 EMC77040.1 - 0.012 15.1 0.1 0.04 13.5 0.1 2.0 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 EMC77040.1 - 0.12 12.8 0.0 0.42 11.1 0.0 2.0 1 0 0 1 1 1 0 EF-hand domain pair Churchill PF06573.11 EMC77040.1 - 2.1 8.7 10.6 0.69 10.3 4.3 3.0 2 0 0 2 2 2 0 Churchill protein E1-E2_ATPase PF00122.20 EMC77042.1 - 4.9e-55 185.9 7.9 5.7e-55 185.6 0.4 3.1 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EMC77042.1 - 6.9e-45 153.0 3.5 6.9e-45 153.0 3.5 2.3 4 0 0 4 4 4 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 EMC77042.1 - 3.7e-21 75.0 0.9 6.6e-21 74.2 0.9 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EMC77042.1 - 2.5e-18 67.1 0.0 1.9e-17 64.3 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EMC77042.1 - 7.5e-07 29.1 1.3 1.2e-06 28.5 0.3 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EMC77042.1 - 3.4e-05 23.5 0.1 3.4e-05 23.5 0.1 2.1 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus HAD PF12710.7 EMC77042.1 - 0.00096 19.6 0.0 0.0029 18.0 0.0 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Pkinase PF00069.25 EMC77043.1 - 9.8e-65 218.5 0.0 1.1e-57 195.4 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMC77043.1 - 3.7e-33 114.9 0.0 3e-31 108.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EMC77043.1 - 6e-09 35.6 0.0 8.8e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMC77043.1 - 3.8e-05 22.7 0.0 6.1e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Mis12 PF05859.12 EMC77044.1 - 2.2e-25 89.3 1.5 2.2e-25 89.3 1.5 1.7 2 0 0 2 2 2 1 Mis12 protein Z1 PF10593.9 EMC77044.1 - 0.01 15.4 2.0 0.34 10.4 0.0 2.9 2 1 1 3 3 3 0 Z1 domain DUF2018 PF09442.10 EMC77044.1 - 0.02 15.8 0.4 0.058 14.4 0.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF2018) FadA PF09403.10 EMC77044.1 - 0.054 14.0 8.1 0.12 12.9 8.1 1.6 1 0 0 1 1 1 0 Adhesion protein FadA Lzipper-MIP1 PF14389.6 EMC77044.1 - 0.064 13.6 5.8 0.11 12.8 4.6 1.9 1 1 1 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 BBP1_C PF15272.6 EMC77044.1 - 0.087 12.6 0.4 0.087 12.6 0.4 2.1 2 0 0 2 2 2 0 Spindle pole body component BBP1, C-terminal Glu-tRNAGln PF02686.15 EMC77044.1 - 0.48 10.8 0.1 0.48 10.8 0.1 2.5 3 0 0 3 3 3 0 Glu-tRNAGln amidotransferase C subunit DUF4140 PF13600.6 EMC77044.1 - 1 9.9 4.8 2 8.9 2.1 2.2 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) FlxA PF14282.6 EMC77044.1 - 1.8 8.6 9.9 0.72 9.9 5.1 2.2 2 0 0 2 2 2 0 FlxA-like protein Cep57_MT_bd PF06657.13 EMC77044.1 - 1.9 9.0 8.6 2.4 8.7 1.5 2.5 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 IZUMO PF15005.6 EMC77044.1 - 2.5 8.6 8.1 0.35 11.4 3.4 1.8 2 0 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated OmpH PF03938.14 EMC77044.1 - 3.1 8.1 14.8 11 6.3 14.8 1.9 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) betaPIX_CC PF16523.5 EMC77044.1 - 5.5 6.9 8.3 6.3 6.7 2.1 2.7 2 1 0 2 2 2 0 betaPIX coiled coil ZapB PF06005.12 EMC77044.1 - 8.3 6.9 12.6 1 9.8 5.5 2.3 2 0 0 2 2 2 0 Cell division protein ZapB DER1 PF04511.15 EMC77045.1 - 3e-67 226.3 12.3 3.4e-67 226.1 12.3 1.0 1 0 0 1 1 1 1 Der1-like family Oleosin PF01277.17 EMC77045.1 - 1.3 8.8 0.0 1.3 8.8 0.0 2.2 1 1 1 2 2 2 0 Oleosin HA2 PF04408.23 EMC77046.1 - 7e-19 68.1 0.0 1.4e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EMC77046.1 - 8.3e-17 61.3 0.0 1.8e-16 60.2 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EMC77046.1 - 9.1e-14 51.7 0.0 2.6e-13 50.3 0.0 1.8 1 1 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EMC77046.1 - 1.7e-05 24.6 0.1 3.5e-05 23.7 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EMC77046.1 - 0.0094 16.2 0.0 0.026 14.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain MAM33 PF02330.16 EMC77047.1 - 4.5e-42 144.4 4.5 5.2e-42 144.2 4.5 1.0 1 0 0 1 1 1 1 Mitochondrial glycoprotein PDDEXK_7 PF04411.12 EMC77047.1 - 0.04 13.9 0.1 0.088 12.8 0.1 1.5 1 1 0 1 1 1 0 PD-(D/E)XK nuclease superfamily Rabaptin PF03528.15 EMC77049.1 - 4.8e-279 925.9 53.1 4.8e-279 925.9 53.1 2.9 2 1 0 2 2 2 1 Rabaptin Rab5-bind PF09311.11 EMC77049.1 - 2e-134 447.8 63.1 2e-134 447.8 63.1 4.3 2 1 1 3 3 3 1 Rabaptin-like protein Fez1 PF06818.15 EMC77049.1 - 0.0034 17.8 23.7 0.0034 17.8 23.7 5.6 2 2 3 5 5 5 2 Fez1 TruB_C_2 PF16198.5 EMC77049.1 - 3 8.1 7.6 1.4 9.1 0.2 4.4 3 0 0 3 3 3 0 tRNA pseudouridylate synthase B C-terminal domain Roc PF08477.13 EMC77050.1 - 3.9e-09 36.7 0.0 5.4e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMC77050.1 - 7.4e-07 28.9 0.0 9.2e-07 28.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Arf PF00025.21 EMC77050.1 - 0.0023 17.4 0.0 0.0024 17.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Collagen PF01391.18 EMC77051.1 - 2.9e-20 71.8 77.0 2.9e-09 36.6 32.0 3.5 2 1 0 2 2 2 2 Collagen triple helix repeat (20 copies) EMI PF07546.13 EMC77051.1 - 7.6e-18 65.0 10.6 1.5e-17 64.1 10.6 1.5 1 0 0 1 1 1 1 EMI domain 3Beta_HSD PF01073.19 EMC77052.1 - 3.5e-48 164.0 0.0 4.3e-48 163.7 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EMC77052.1 - 6.9e-08 32.2 0.0 9e-08 31.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EMC77052.1 - 6.3e-06 25.5 0.0 7.7e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 EMC77052.1 - 0.16 11.1 0.2 5 6.2 0.1 2.1 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein EF-hand_1 PF00036.32 EMC77053.1 - 1.2e-14 52.7 3.7 5e-06 25.7 0.9 3.7 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EMC77053.1 - 1.2e-10 40.4 3.4 2e-06 27.3 0.8 3.1 2 1 1 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 EMC77053.1 - 2e-10 41.0 0.2 9.1e-05 22.8 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EMC77053.1 - 2.2e-08 33.8 1.3 0.015 15.1 0.1 3.9 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 EMC77053.1 - 0.00042 19.7 2.2 0.0017 17.8 1.0 2.6 2 0 0 2 2 2 1 EF hand DUF1168 PF06658.12 EMC77054.1 - 1.4e-47 160.9 22.2 1.8e-47 160.6 22.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) Caldesmon PF02029.15 EMC77054.1 - 0.031 13.0 25.8 0.036 12.8 25.8 1.0 1 0 0 1 1 1 0 Caldesmon DUF4746 PF15928.5 EMC77054.1 - 0.039 13.4 11.8 0.04 13.4 11.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Spem1 PF15670.5 EMC77054.1 - 0.17 11.5 8.4 0.22 11.1 8.4 1.3 1 0 0 1 1 1 0 Spermatid maturation protein 1 BPL_N PF09825.9 EMC77054.1 - 0.17 10.9 8.6 0.23 10.5 8.6 1.0 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal GAGA_bind PF06217.12 EMC77054.1 - 0.2 11.9 10.9 0.22 11.8 10.9 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DDHD PF02862.17 EMC77054.1 - 0.32 11.1 4.3 0.36 10.9 4.3 1.2 1 0 0 1 1 1 0 DDHD domain CNDH2_C PF16858.5 EMC77054.1 - 0.54 10.1 18.5 0.74 9.6 18.5 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term FAM60A PF15396.6 EMC77054.1 - 0.56 10.2 12.3 0.76 9.8 12.3 1.2 1 0 0 1 1 1 0 Protein Family FAM60A DASH_Spc19 PF08287.11 EMC77054.1 - 0.81 9.6 19.5 1.4 8.8 19.5 1.4 1 0 0 1 1 1 0 Spc19 Vfa1 PF08432.10 EMC77054.1 - 1.2 9.5 22.9 1.7 9.0 22.9 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 V_ATPase_I PF01496.19 EMC77054.1 - 1.9 6.3 10.4 2.1 6.1 10.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peptidase_C58 PF03543.14 EMC77054.1 - 2.6 7.7 10.9 3.5 7.3 10.9 1.2 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen RR_TM4-6 PF06459.12 EMC77054.1 - 3 7.6 16.3 4.1 7.1 16.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CobT PF06213.12 EMC77054.1 - 3.1 7.1 22.6 4.2 6.7 22.6 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT AAA_11 PF13086.6 EMC77054.1 - 7.4 6.3 13.2 8.8 6.0 13.2 1.1 1 0 0 1 1 1 0 AAA domain RP-C_C PF11800.8 EMC77054.1 - 9.1 6.3 12.4 15 5.6 12.4 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region Orai-1 PF07856.12 EMC77055.1 - 3.4e-71 238.5 7.9 4.1e-71 238.2 7.9 1.1 1 0 0 1 1 1 1 Mediator of CRAC channel activity DUF2207 PF09972.9 EMC77055.1 - 0.23 10.2 2.9 0.35 9.6 2.9 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) zf-LITAF-like PF10601.9 EMC77055.1 - 0.5 10.7 4.8 5.9 7.2 0.0 3.2 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain Asp5 PF17000.5 EMC77055.1 - 5.2 7.3 8.7 0.92 9.7 1.7 2.2 2 0 0 2 2 2 0 Accessory secretory protein Sec, Asp5 DHHC PF01529.20 EMC77055.1 - 7.2 6.7 8.1 5.2 7.2 1.9 2.4 1 1 2 3 3 3 0 DHHC palmitoyltransferase 2OG-FeII_Oxy_2 PF13532.6 EMC77056.1 - 0.00029 21.1 0.0 0.0004 20.6 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 EMC77056.1 - 0.017 15.6 0.0 0.034 14.6 0.0 1.7 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily RNA_pol_L_2 PF13656.6 EMC77057.1 - 9e-30 102.3 0.1 1.1e-29 102.0 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EMC77057.1 - 1e-10 40.9 0.0 1.3e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RasGAP PF00616.19 EMC77058.1 - 3.8e-33 115.0 0.0 1.8e-32 112.7 0.0 1.8 1 1 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 EMC77059.1 - 2.1e-17 63.3 0.0 3.8e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 C2 domain DTC PF18102.1 EMC77060.1 - 1.4e-61 206.5 0.0 2.4e-61 205.7 0.0 1.4 1 0 0 1 1 1 1 Deltex C-terminal domain WWE PF02825.20 EMC77060.1 - 2.2e-35 121.0 1.1 9.2e-17 61.4 0.0 2.4 2 0 0 2 2 2 2 WWE domain zf-C3HC4 PF00097.25 EMC77060.1 - 0.00043 20.1 7.8 0.0011 18.7 7.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-UDP PF14569.6 EMC77060.1 - 0.0045 17.1 1.4 0.013 15.6 1.4 1.7 1 0 0 1 1 1 1 Zinc-binding RING-finger zf-RING_UBOX PF13445.6 EMC77060.1 - 0.0081 16.2 4.6 0.023 14.7 4.6 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 EMC77060.1 - 0.0097 16.2 5.8 0.026 14.8 5.8 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EMC77060.1 - 0.015 15.3 1.6 0.057 13.5 1.6 2.0 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 EMC77060.1 - 0.05 13.4 7.4 0.29 10.9 1.9 2.7 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_2 PF13639.6 EMC77060.1 - 0.12 12.8 15.2 0.055 13.8 9.7 2.8 2 1 0 2 2 2 0 Ring finger domain zf-HC5HC2H_2 PF13832.6 EMC77060.1 - 0.54 10.4 4.9 0.47 10.6 2.6 2.1 1 1 0 1 1 1 0 PHD-zinc-finger like domain zf-RING_5 PF14634.6 EMC77060.1 - 0.99 9.4 9.0 0.4 10.7 5.7 2.1 2 1 0 2 2 2 0 zinc-RING finger domain PHD PF00628.29 EMC77060.1 - 4.7 7.2 8.4 0.84 9.6 3.6 2.4 2 0 0 2 2 2 0 PHD-finger 14-3-3 PF00244.20 EMC77061.1 - 2.5e-96 321.5 7.6 2.8e-96 321.3 7.6 1.0 1 0 0 1 1 1 1 14-3-3 protein SF3A2 PF16835.5 EMC77061.1 - 0.06 13.7 0.1 0.13 12.6 0.1 1.6 1 0 0 1 1 1 0 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) Peptidase_C98 PF15499.6 EMC77061.1 - 0.069 12.6 0.1 0.12 11.8 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase FlaC_arch PF05377.11 EMC77061.1 - 0.13 12.7 0.8 0.35 11.3 0.8 1.7 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) SRP-alpha_N PF04086.13 EMC77062.1 - 0.44 10.4 18.6 0.52 10.2 18.6 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal eIF-3_zeta PF05091.12 EMC77062.1 - 1.1 8.1 9.9 1.2 8.1 9.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CDC45 PF02724.14 EMC77062.1 - 2.2 6.5 20.4 2.6 6.3 20.4 1.2 1 0 0 1 1 1 0 CDC45-like protein GREB1 PF15782.5 EMC77062.1 - 5.7 3.9 11.7 5.9 3.9 11.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 EMC77062.1 - 7.7 5.2 14.1 8.9 5.0 14.1 1.3 1 0 0 1 1 1 0 Presenilin Ldh_1_C PF02866.18 EMC77063.1 - 3.7e-56 189.6 0.0 7.1e-56 188.7 0.0 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EMC77063.1 - 3.4e-48 163.3 0.0 5e-48 162.8 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 EMC77063.1 - 0.0022 18.4 0.0 0.016 15.6 0.0 2.1 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EMC77063.1 - 0.0044 16.1 0.0 0.0063 15.6 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.19 EMC77063.1 - 0.086 12.1 0.1 0.48 9.7 0.1 2.2 1 1 1 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DSPc PF00782.20 EMC77064.1 - 8.1e-22 77.5 0.1 1.2e-21 76.9 0.1 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 EMC77064.1 - 1.4e-06 28.7 0.0 4.6e-06 27.1 0.0 1.8 1 1 0 1 1 1 1 Rhodanese-like domain TMPIT PF07851.13 EMC77065.1 - 9.7e-155 514.7 18.7 1.2e-154 514.4 18.7 1.0 1 0 0 1 1 1 1 TMPIT-like protein FAD_binding_1 PF00667.20 EMC77066.1 - 4.2e-80 268.5 0.0 6.7e-80 267.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EMC77066.1 - 4.4e-40 137.2 0.2 1.7e-39 135.3 0.3 2.0 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 EMC77066.1 - 3.7e-20 72.6 0.1 5.2e-19 68.9 0.0 2.8 3 0 0 3 3 3 1 Oxidoreductase NAD-binding domain Glyco_tran_WecB PF03808.13 EMC77066.1 - 0.099 12.6 0.0 0.63 10.0 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family RRM_1 PF00076.22 EMC77067.1 - 8e-13 48.0 0.1 4.1e-12 45.8 0.1 2.1 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP PF00641.18 EMC77067.1 - 2.7e-08 33.0 5.9 4e-08 32.4 5.9 1.3 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Peptidase_M10 PF00413.24 EMC77068.1 - 2.7e-49 167.0 0.0 4.3e-49 166.4 0.0 1.3 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 EMC77068.1 - 3.8e-30 103.6 8.3 4.7e-08 32.9 0.0 4.7 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.18 EMC77068.1 - 5.4e-06 26.5 0.0 1.1e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Reprolysin_4 PF13583.6 EMC77068.1 - 0.00028 20.6 0.1 0.00045 19.9 0.1 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 EMC77068.1 - 0.00058 19.2 0.1 0.00088 18.6 0.1 1.2 1 0 0 1 1 1 1 Met-zincin Reprolysin_5 PF13688.6 EMC77068.1 - 0.0036 17.5 0.1 0.006 16.8 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EMC77068.1 - 0.0047 17.4 1.0 0.0081 16.7 1.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.8 EMC77068.1 - 0.019 14.6 0.1 0.033 13.8 0.1 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Metallopep PF12044.8 EMC77068.1 - 0.056 12.0 0.0 0.087 11.4 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family Peptidase_M54 PF07998.11 EMC77068.1 - 0.068 13.1 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M54 Peptidase_M66 PF10462.9 EMC77068.1 - 0.098 11.6 0.0 0.19 10.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase M66 Astacin PF01400.24 EMC77068.1 - 0.14 11.7 0.4 0.41 10.2 0.1 1.8 3 0 0 3 3 3 0 Astacin (Peptidase family M12A) Reprolysin_2 PF13574.6 EMC77068.1 - 0.2 11.5 0.0 0.32 10.9 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like GAS2 PF02187.17 EMC77069.1 - 5.4e-33 112.9 0.1 9.1e-33 112.2 0.1 1.4 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain CH PF00307.31 EMC77069.1 - 3e-15 56.3 0.0 5.8e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain Ras PF00071.22 EMC77070.1 - 3.3e-25 88.6 0.0 6.4e-25 87.6 0.0 1.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EMC77070.1 - 4.4e-08 33.4 0.0 4.1e-07 30.2 0.0 2.0 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC77070.1 - 0.00066 19.2 0.0 0.011 15.2 0.0 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC77070.1 - 0.0025 17.9 0.0 0.0035 17.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EMC77070.1 - 0.022 15.1 0.0 0.043 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.6 EMC77070.1 - 0.051 13.8 0.0 0.082 13.2 0.0 1.4 1 1 0 1 1 1 0 AAA domain Adaptin_N PF01602.20 EMC77071.1 - 1.3e-148 495.9 13.6 1.6e-148 495.6 13.6 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EMC77071.1 - 1e-68 230.5 5.8 2.3e-66 222.8 1.5 3.0 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 EMC77071.1 - 1.1e-37 128.6 0.1 3.2e-37 127.0 0.1 1.9 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.6 EMC77071.1 - 1.1e-20 73.8 4.5 6.2e-06 26.5 0.0 6.0 3 2 3 7 7 6 5 HEAT repeats HEAT PF02985.22 EMC77071.1 - 4.9e-13 48.1 8.8 0.0081 16.3 0.1 7.6 7 0 0 7 7 7 3 HEAT repeat Alpha_adaptinC2 PF02883.20 EMC77071.1 - 2.2e-12 47.3 0.4 4.6e-12 46.2 0.4 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain Arm PF00514.23 EMC77071.1 - 4.5e-08 32.9 1.9 0.027 14.5 0.0 5.3 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 EMC77071.1 - 0.00018 21.7 3.3 0.69 10.1 0.0 4.9 1 1 1 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 Arm_2 PF04826.13 EMC77071.1 - 0.0019 17.7 1.2 0.04 13.4 0.2 2.6 1 1 1 2 2 2 1 Armadillo-like HEAT_EZ PF13513.6 EMC77071.1 - 0.005 17.3 4.2 12 6.5 0.0 5.7 6 0 0 6 6 6 1 HEAT-like repeat CLASP_N PF12348.8 EMC77071.1 - 0.0057 16.3 2.3 1.9 8.0 0.2 4.0 2 2 1 3 3 3 1 CLASP N terminal Sec7_N PF12783.7 EMC77071.1 - 0.0069 16.3 4.2 0.022 14.7 0.2 3.4 5 0 0 5 5 5 1 Guanine nucleotide exchange factor in Golgi transport N-terminal TIP120 PF08623.10 EMC77071.1 - 0.017 14.9 5.6 3.8 7.3 0.0 4.6 4 1 0 4 4 4 0 TATA-binding protein interacting (TIP20) Pex2_Pex12 PF04757.14 EMC77072.1 - 8.5e-46 156.3 3.2 1e-45 156.1 3.2 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 EMC77072.1 - 7.6e-05 22.5 2.3 0.00013 21.8 2.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC77072.1 - 0.00034 20.4 1.0 0.00058 19.6 1.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC77072.1 - 0.0067 16.3 1.2 0.011 15.5 1.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC77072.1 - 0.03 14.3 0.9 1.3 9.0 0.1 2.2 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_2 PF13639.6 EMC77072.1 - 0.03 14.6 5.0 0.2 12.0 5.1 2.1 1 1 1 2 2 2 0 Ring finger domain RTA1 PF04479.13 EMC77072.1 - 0.034 13.8 0.0 0.074 12.6 0.0 1.6 1 1 0 1 1 1 0 RTA1 like protein zf-rbx1 PF12678.7 EMC77072.1 - 3 8.2 4.5 35 4.8 4.6 2.2 1 1 1 2 2 2 0 RING-H2 zinc finger domain AlbA_2 PF04326.14 EMC77073.1 - 3.6e-17 62.8 0.1 3e-12 46.9 0.0 2.6 2 0 0 2 2 2 2 Putative DNA-binding domain DUF2075 PF09848.9 EMC77073.1 - 1.3e-06 28.0 0.0 2.3e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 EMC77073.1 - 0.001 18.6 0.8 0.44 10.0 0.0 2.6 1 1 1 2 2 2 2 PhoH-like protein AAA_22 PF13401.6 EMC77073.1 - 0.0035 17.6 0.1 0.33 11.2 0.1 2.6 1 1 0 1 1 1 1 AAA domain PIF1 PF05970.14 EMC77073.1 - 0.0051 16.0 0.1 0.012 14.8 0.0 1.7 2 0 0 2 2 2 1 PIF1-like helicase AAA_14 PF13173.6 EMC77073.1 - 0.0055 16.7 0.1 0.016 15.3 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EMC77073.1 - 0.0056 17.0 0.1 0.12 12.7 0.1 2.5 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EMC77073.1 - 0.0096 16.4 0.1 0.046 14.2 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EMC77073.1 - 0.013 15.3 0.0 0.025 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 EMC77073.1 - 0.02 14.9 0.1 0.07 13.1 0.1 2.0 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Bac_DnaA PF00308.18 EMC77073.1 - 0.031 14.1 0.1 0.071 12.9 0.1 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein B3R PF17057.5 EMC77073.1 - 0.041 14.1 0.0 0.097 12.9 0.0 1.6 1 0 0 1 1 1 0 Poxviridae B3 protein AAA_30 PF13604.6 EMC77073.1 - 0.046 13.4 0.0 0.088 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EMC77073.1 - 0.064 13.2 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 NACHT domain NB-ARC PF00931.22 EMC77073.1 - 0.066 12.4 0.0 0.17 11.1 0.0 1.7 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.22 EMC77073.1 - 0.068 13.6 0.0 0.19 12.1 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_11 PF13086.6 EMC77073.1 - 0.085 12.6 0.2 0.27 11.0 0.0 1.8 1 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EMC77073.1 - 0.086 13.4 0.0 3.8 8.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EMC77073.1 - 0.17 11.2 0.0 0.6 9.4 0.0 1.9 2 0 0 2 2 2 0 KaiC zf-C3HC4_3 PF13920.6 EMC77074.1 - 3.4e-12 46.0 12.0 3.4e-12 46.0 12.0 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Armet PF10208.9 EMC77074.1 - 1.7e-06 28.0 2.1 0.047 13.6 0.1 2.5 2 0 0 2 2 2 2 Degradation arginine-rich protein for mis-folding FYVE_2 PF02318.16 EMC77074.1 - 0.00014 22.0 5.3 0.00014 22.0 5.3 2.6 2 1 0 2 2 2 1 FYVE-type zinc finger Prok-RING_4 PF14447.6 EMC77074.1 - 0.00056 19.7 11.9 0.00056 19.7 11.9 2.6 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 SAP PF02037.27 EMC77074.1 - 0.0015 18.2 2.3 0.67 9.8 0.1 3.3 4 0 0 4 4 4 2 SAP domain zf-RING_5 PF14634.6 EMC77074.1 - 0.0074 16.2 12.0 0.0074 16.2 12.0 2.6 2 0 0 2 2 2 1 zinc-RING finger domain Siva PF05458.12 EMC77074.1 - 0.011 15.4 2.0 0.011 15.4 2.0 2.2 2 0 0 2 2 2 0 Cd27 binding protein (Siva) FYVE PF01363.21 EMC77074.1 - 0.019 15.1 10.9 0.019 15.1 10.9 3.5 2 2 0 2 2 2 0 FYVE zinc finger Zn_Tnp_IS91 PF14319.6 EMC77074.1 - 3.3 7.8 17.0 5.7 7.1 5.6 2.7 2 0 0 2 2 2 0 Transposase zinc-binding domain zf-C3HC4_4 PF15227.6 EMC77074.1 - 5.8 7.2 25.8 1.8 8.8 5.2 3.9 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING IL8 PF00048.20 EMC77076.1 - 1.5e-14 53.9 5.2 1.5e-14 53.9 5.2 1.6 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like IL8 PF00048.20 EMC77077.1 - 9e-13 48.2 2.3 1.1e-12 47.8 2.3 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like IL8 PF00048.20 EMC77078.1 - 5.4e-21 74.5 0.6 6.6e-21 74.2 0.6 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like zf-HC5HC2H PF13771.6 EMC77079.1 - 1.5e-14 54.0 4.3 1.5e-14 54.0 4.3 3.5 3 0 0 3 3 3 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EMC77079.1 - 0.00053 20.1 10.3 0.00053 20.1 10.3 3.4 2 1 1 3 3 3 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EMC77080.1 - 1.9e-14 53.7 4.1 1.9e-14 53.7 4.1 3.9 4 0 0 4 4 4 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EMC77080.1 - 0.0031 17.7 12.0 0.0031 17.7 12.0 3.7 2 1 1 3 3 3 1 PHD-zinc-finger like domain IL8 PF00048.20 EMC77081.1 - 2.9e-07 30.6 0.5 3.9e-07 30.1 0.5 1.2 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like ERM PF00769.19 EMC77082.1 - 9.7e-46 156.6 45.2 9.7e-46 156.6 45.2 2.2 2 0 0 2 2 2 1 Ezrin/radixin/moesin family FERM_M PF00373.18 EMC77082.1 - 8.9e-27 93.8 1.3 8.9e-27 93.8 1.3 2.8 2 1 0 2 2 2 1 FERM central domain FERM_C PF09380.10 EMC77082.1 - 3.6e-22 78.6 0.2 3.6e-22 78.6 0.2 2.6 3 0 0 3 3 3 1 FERM C-terminal PH-like domain FERM_N PF09379.10 EMC77082.1 - 2.1e-10 40.4 0.3 1.2e-09 37.9 0.3 2.4 1 0 0 1 1 1 1 FERM N-terminal domain Ribosomal_S17 PF00366.20 EMC77083.1 - 3.3e-19 68.8 0.1 4.8e-19 68.2 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S17 NIPSNAP PF07978.13 EMC77084.1 - 1.2e-38 131.4 0.9 1.3e-32 112.0 0.2 2.2 2 0 0 2 2 2 2 NIPSNAP Hydrolase PF00702.26 EMC77085.1 - 1.3e-18 68.1 0.0 2.1e-18 67.4 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EMC77085.1 - 7.8e-14 52.5 0.0 1.3e-13 51.7 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EMC77085.1 - 1.9e-06 28.1 0.0 0.004 17.3 0.0 2.6 3 0 0 3 3 3 2 Haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 EMC77085.1 - 5.9e-06 26.0 0.0 1.1e-05 25.0 0.0 1.5 1 1 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) Put_Phosphatase PF06888.12 EMC77085.1 - 4.1e-05 23.1 0.0 0.00013 21.4 0.0 1.7 2 1 0 2 2 2 1 Putative Phosphatase Acid_phosphat_B PF03767.14 EMC77085.1 - 0.00088 18.9 0.0 0.053 13.1 0.0 2.1 2 0 0 2 2 2 1 HAD superfamily, subfamily IIIB (Acid phosphatase) Hydrolase_3 PF08282.12 EMC77085.1 - 0.01 15.6 0.0 0.59 9.8 0.0 2.5 2 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase StbA PF06406.11 EMC77085.1 - 0.028 13.7 0.0 0.09 12.0 0.0 1.7 2 0 0 2 2 2 0 StbA protein Hydrolase_like PF13242.6 EMC77085.1 - 0.095 12.8 0.0 0.2 11.7 0.0 1.7 1 1 0 1 1 1 0 HAD-hyrolase-like FGE-sulfatase PF03781.16 EMC77086.1 - 4.4e-59 200.2 4.7 5.1e-59 200.0 4.7 1.1 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 Pkinase PF00069.25 EMC77087.1 - 1.1e-78 264.2 0.0 1.4e-78 263.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC77087.1 - 3.1e-33 115.1 0.0 4e-33 114.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC77087.1 - 1e-11 44.7 0.0 6.1e-10 38.9 0.0 2.1 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 EMC77087.1 - 3.7e-07 29.7 0.1 6.8e-07 28.8 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EMC77087.1 - 9.4e-06 24.8 0.5 1.8e-05 23.9 0.5 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EMC77087.1 - 9.7e-06 24.6 0.1 0.00022 20.1 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EMC77087.1 - 6.1e-05 23.1 0.3 0.36 10.7 0.3 2.8 2 1 1 3 3 3 2 Phosphotransferase enzyme family RIO1 PF01163.22 EMC77087.1 - 9e-05 22.1 1.0 0.00018 21.1 0.2 1.9 2 0 0 2 2 2 1 RIO1 family FTA2 PF13095.6 EMC77087.1 - 0.0018 17.9 0.1 0.38 10.4 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 EMC77087.1 - 0.0076 15.9 0.2 0.014 15.0 0.2 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Spc110_C PF18520.1 EMC77087.1 - 0.026 14.1 0.3 0.2 11.3 0.1 2.2 2 0 0 2 2 2 0 Spindle pole body component 110 C-terminal domain YrbL-PhoP_reg PF10707.9 EMC77087.1 - 0.12 11.9 0.1 0.25 10.9 0.1 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL CHCH PF06747.13 EMC77088.1 - 1.9e-06 27.8 7.8 2.8e-06 27.3 7.8 1.3 1 0 0 1 1 1 1 CHCH domain Nup54_C PF18437.1 EMC77088.1 - 0.23 11.4 0.1 0.44 10.5 0.1 1.5 1 0 0 1 1 1 0 Nup54 C-terminal interacting domain VKOR PF07884.14 EMC77089.1 - 1.1e-15 57.9 13.6 1.3e-15 57.7 13.6 1.1 1 0 0 1 1 1 1 Vitamin K epoxide reductase family G3P_acyltransf PF02660.15 EMC77089.1 - 0.74 9.9 9.2 0.93 9.5 9.2 1.1 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase Tmemb_55A PF09788.9 EMC77089.1 - 1.2 8.2 5.3 1.4 7.9 5.3 1.1 1 0 0 1 1 1 0 Transmembrane protein 55A SPC25 PF06703.11 EMC77089.1 - 6.6 6.5 11.9 6.8 6.5 10.7 1.6 1 1 1 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Glyco_hydro_2_C PF02836.17 EMC77090.1 - 1.8e-106 355.7 0.0 2.4e-106 355.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 EMC77090.1 - 1.2e-18 67.5 0.0 2.3e-18 66.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 EMC77090.1 - 5.2e-05 23.9 1.1 0.00031 21.4 1.1 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 2 RNA_pol_Rpb4 PF03874.16 EMC77091.1 - 1.8e-27 96.1 3.3 2.3e-27 95.7 3.3 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 Muted PF14942.6 EMC77091.1 - 0.00022 21.6 1.4 0.0019 18.5 0.2 2.2 2 0 0 2 2 2 1 Organelle biogenesis, Muted-like protein Sulfotransfer_3 PF13469.6 EMC77092.1 - 2.7e-54 184.8 0.0 4.2e-54 184.2 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 EMC77092.1 - 2.4e-08 33.8 0.1 2.2e-07 30.6 0.1 2.3 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_4 PF17784.1 EMC77092.1 - 0.0015 18.4 0.1 0.0094 15.8 0.1 2.3 1 1 1 2 2 2 1 Sulfotransferase domain BTB_2 PF02214.22 EMC77093.1 - 2.5e-20 72.6 0.1 1.4e-19 70.2 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain BTB_3 PF16017.5 EMC77093.1 - 0.0054 16.8 0.0 0.0091 16.1 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain VPS9 PF02204.18 EMC77094.1 - 1.5e-29 102.2 0.0 5.1e-29 100.6 0.0 2.0 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EMC77094.1 - 5.1e-21 74.8 1.7 1.7e-20 73.1 1.7 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) zf-A20 PF01754.16 EMC77094.1 - 4.3e-12 45.7 6.8 9e-12 44.7 6.8 1.6 1 0 0 1 1 1 1 A20-like zinc finger Syntaxin PF00804.25 EMC77094.1 - 0.07 12.8 11.8 0.91 9.2 5.5 2.7 2 1 1 3 3 3 0 Syntaxin SSTK-IP PF15836.5 EMC77094.1 - 0.075 13.2 0.1 0.28 11.3 0.0 1.9 2 0 0 2 2 2 0 SSTK-interacting protein, TSSK6-activating co-chaperone protein Flavodoxin_NdrI PF07972.11 EMC77094.1 - 0.15 12.3 0.8 0.88 9.8 0.1 2.4 1 1 1 2 2 2 0 NrdI Flavodoxin like GIT1_C PF12205.8 EMC77094.1 - 1.9 8.6 8.3 4.9 7.3 0.1 3.8 4 1 0 4 4 4 0 G protein-coupled receptor kinase-interacting protein 1 C term Mit_KHE1 PF10173.9 EMC77094.1 - 6.3 6.8 7.3 4.7 7.2 0.0 2.9 3 0 0 3 3 3 0 Mitochondrial K+-H+ exchange-related TMEM219 PF14940.6 EMC77095.1 - 1.9e-87 292.7 0.5 2.5e-87 292.4 0.5 1.1 1 0 0 1 1 1 1 Transmembrane 219 Omp28 PF11551.8 EMC77095.1 - 0.049 13.5 0.0 0.096 12.5 0.0 1.5 1 0 0 1 1 1 0 Outer membrane protein Omp28 T2SSK PF03934.13 EMC77097.1 - 0.00079 18.9 1.4 0.0024 17.3 0.3 1.9 2 0 0 2 2 2 1 Type II secretion system (T2SS), protein K LRR_4 PF12799.7 EMC77097.1 - 0.0044 17.4 1.6 0.02 15.3 0.7 2.5 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EMC77097.1 - 0.08 13.0 0.7 0.48 10.6 0.2 2.5 2 0 0 2 2 2 0 Leucine Rich repeat SH3_2 PF07653.17 EMC77098.1 - 1.6e-24 85.4 1.0 6.7e-11 41.7 0.0 2.9 3 0 0 3 3 3 2 Variant SH3 domain SH3_1 PF00018.28 EMC77098.1 - 9.1e-19 66.8 0.5 3.7e-15 55.3 0.2 2.5 2 0 0 2 2 2 2 SH3 domain SH2 PF00017.24 EMC77098.1 - 1.5e-17 63.5 0.0 4.5e-17 61.9 0.0 1.8 1 1 0 1 1 1 1 SH2 domain SH3_9 PF14604.6 EMC77098.1 - 2.2e-13 49.8 0.1 4.3e-09 36.1 0.1 2.7 2 0 0 2 2 2 2 Variant SH3 domain SH3_10 PF17902.1 EMC77098.1 - 0.094 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 SH3 domain DUF3804 PF12707.7 EMC77098.1 - 0.19 11.5 0.0 0.7 9.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3804) 14-3-3 PF00244.20 EMC77099.1 - 1.2e-100 335.6 0.8 1.4e-100 335.4 0.8 1.0 1 0 0 1 1 1 1 14-3-3 protein Orbi_VP5 PF00901.17 EMC77099.1 - 0.064 11.6 0.5 0.1 11.0 0.5 1.3 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 Myosin_head PF00063.21 EMC77100.1 - 1.6e-252 839.7 5.0 2e-252 839.3 5.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EMC77100.1 - 1.4e-31 109.6 1.3 1.4e-31 109.6 1.3 1.8 2 0 0 2 2 2 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.27 EMC77100.1 - 0.0011 18.6 17.1 0.0024 17.5 1.0 4.0 4 0 0 4 4 4 2 IQ calmodulin-binding motif AAA_22 PF13401.6 EMC77100.1 - 0.009 16.3 0.0 0.065 13.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EMC77100.1 - 0.017 15.5 0.0 0.08 13.3 0.0 2.1 3 0 0 3 3 3 0 AAA ATPase domain Zeta_toxin PF06414.12 EMC77100.1 - 0.027 13.8 0.0 0.059 12.7 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin TsaE PF02367.17 EMC77100.1 - 0.08 12.9 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SKICH PF17751.1 EMC77101.1 - 1.3e-30 106.0 0.3 2.4e-30 105.1 0.3 1.5 1 0 0 1 1 1 1 SKICH domain Exo_endo_phos PF03372.23 EMC77101.1 - 1.9e-10 40.7 0.0 2.8e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family IP_trans PF02121.18 EMC77102.1 - 1.4e-108 362.2 2.9 1.6e-108 362.0 2.9 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein DUF5595 PF18077.1 EMC77102.1 - 0.26 11.4 2.1 0.53 10.4 2.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) PROCN PF08083.11 EMC77103.1 - 4.9e-237 786.3 8.2 4.9e-237 786.3 8.2 1.6 2 0 0 2 2 2 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 EMC77103.1 - 2.2e-130 433.2 0.6 3.9e-130 432.4 0.6 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 EMC77103.1 - 9.5e-90 298.6 3.4 2.2e-89 297.5 3.4 1.7 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 EMC77103.1 - 4.7e-87 289.6 5.4 4.7e-87 289.6 3.7 2.0 2 0 0 2 2 2 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 EMC77103.1 - 3.9e-74 247.1 0.0 7.9e-74 246.1 0.0 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.11 EMC77103.1 - 4.2e-54 181.7 0.0 1e-53 180.5 0.0 1.7 1 0 0 1 1 1 1 PROCT (NUC072) domain RRM_4 PF10598.9 EMC77103.1 - 2e-48 162.7 0.7 5.3e-48 161.3 0.7 1.8 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 JAB PF01398.21 EMC77103.1 - 1.5e-13 50.8 0.0 4.2e-13 49.3 0.0 1.8 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease TRAM_LAG1_CLN8 PF03798.16 EMC77105.1 - 1.6e-18 67.1 9.8 1.9e-18 66.9 9.8 1.0 1 0 0 1 1 1 1 TLC domain DUF1614 PF07758.11 EMC77105.1 - 0.03 14.3 1.9 0.039 14.0 1.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1614) Pyr_redox_2 PF07992.14 EMC77106.1 - 2e-42 145.4 0.0 4.9e-20 71.9 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 EMC77106.1 - 9.1e-14 51.2 0.1 2.2e-13 50.0 0.1 1.7 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Reductase_C PF14759.6 EMC77106.1 - 2e-08 34.7 0.0 4.3e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 Reductase C-terminal Pyr_redox PF00070.27 EMC77106.1 - 3.4e-07 30.7 0.5 0.062 13.9 0.0 3.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMC77106.1 - 2.1e-06 27.2 0.2 0.0012 18.2 0.0 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Rieske_2 PF13806.6 EMC77106.1 - 1.7e-05 24.7 0.0 6.1e-05 22.9 0.0 2.0 2 0 0 2 2 2 1 Rieske-like [2Fe-2S] domain FAD_binding_2 PF00890.24 EMC77106.1 - 0.00072 18.8 0.0 3.4 6.6 0.0 3.1 3 0 0 3 3 3 2 FAD binding domain DAO PF01266.24 EMC77106.1 - 0.041 13.5 0.1 0.56 9.7 0.0 2.3 2 1 1 3 3 3 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EMC77106.1 - 0.054 12.2 0.1 5.4 5.6 0.0 3.0 3 0 0 3 3 3 0 HI0933-like protein NAD_binding_8 PF13450.6 EMC77106.1 - 0.054 13.7 0.2 0.13 12.5 0.2 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Beach PF02138.18 EMC77107.1 - 2.3e-36 125.6 0.1 4.1e-34 118.2 0.1 2.3 1 1 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.32 EMC77107.1 - 3.3e-13 49.9 8.0 3.8e-06 27.5 0.0 6.4 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC77107.1 - 0.057 13.7 0.0 0.89 9.9 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain BSP_II PF05432.11 EMC77107.1 - 2.3 7.8 10.0 3.7 7.1 10.0 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Serpin PF00079.20 EMC77108.1 - 1.6e-86 291.0 0.6 1.9e-86 290.7 0.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 EMC77109.1 - 2.3e-86 290.4 0.1 2.7e-86 290.2 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SET PF00856.28 EMC77110.1 - 1e-13 52.0 0.0 1.1e-12 48.7 0.0 2.6 3 1 0 3 3 3 1 SET domain TPR_2 PF07719.17 EMC77110.1 - 2.6e-07 30.2 5.2 0.0072 16.4 0.1 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EMC77110.1 - 7.9e-07 29.3 3.8 1.8e-05 25.0 0.7 3.2 2 1 0 2 2 2 1 Tetratricopeptide repeat zf-MYND PF01753.18 EMC77110.1 - 1.3e-06 28.4 14.7 1.3e-06 28.4 14.7 3.5 3 0 0 3 3 2 1 MYND finger TPR_1 PF00515.28 EMC77110.1 - 0.00018 21.2 0.2 0.094 12.6 0.0 3.2 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 EMC77110.1 - 0.00021 21.1 1.7 0.0007 19.4 0.0 2.9 4 0 0 4 4 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC77110.1 - 0.00034 20.8 4.6 0.41 10.9 0.1 3.9 3 1 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EMC77110.1 - 0.00078 19.3 2.5 0.014 15.4 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EMC77110.1 - 0.0033 18.1 6.6 0.097 13.5 0.1 4.6 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EMC77110.1 - 0.046 13.1 5.4 0.055 12.8 1.2 2.8 2 1 0 2 2 2 0 MalT-like TPR region TPR_16 PF13432.6 EMC77110.1 - 0.06 14.0 2.8 22 5.8 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EMC77110.1 - 0.094 13.2 4.0 3.3 8.3 0.1 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.14 EMC77110.1 - 0.16 12.7 12.2 0.19 12.5 0.8 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMC77110.1 - 1.4 9.7 3.2 1.2e+02 3.7 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Rep_fac-A_C PF08646.10 EMC77111.1 - 5.7e-55 185.1 13.0 1.1e-51 174.4 8.5 2.8 3 0 0 3 3 3 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 EMC77111.1 - 7.1e-39 131.7 1.0 1.1e-36 124.7 0.5 2.4 2 0 0 2 2 2 1 Replication protein A OB domain Rep-A_N PF04057.12 EMC77111.1 - 6.6e-27 93.5 0.1 1.2e-26 92.6 0.1 1.5 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.25 EMC77111.1 - 1.3e-12 47.5 0.4 6.1e-11 42.1 0.0 3.2 2 1 1 3 3 3 1 OB-fold nucleic acid binding domain DUF5521 PF17659.1 EMC77111.1 - 0.0042 15.0 0.0 0.0073 14.2 0.0 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5521) DUF223 PF02721.14 EMC77111.1 - 0.07 13.4 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF223 DUF4939 PF16297.5 EMC77111.1 - 0.08 12.8 0.0 0.28 11.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4939) IBR PF01485.21 EMC77111.1 - 0.11 12.8 3.7 0.27 11.5 3.7 1.6 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain LRR_8 PF13855.6 EMC77112.1 - 3.6e-28 97.1 17.1 2.9e-11 43.0 0.7 3.8 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EMC77112.1 - 3.7e-16 59.0 10.9 0.00011 22.5 0.0 4.6 4 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC77112.1 - 5e-07 29.7 0.0 0.0041 17.1 0.0 3.4 2 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC77112.1 - 2.2e-05 24.0 0.1 0.045 13.3 0.0 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 EMC77112.1 - 0.004 17.5 19.4 4.7 8.2 0.2 7.4 8 1 1 9 9 9 2 Leucine Rich Repeat LRR_6 PF13516.6 EMC77112.1 - 0.15 12.2 0.5 35 4.8 0.1 3.2 2 0 0 2 2 2 0 Leucine Rich repeat LRRNT PF01462.18 EMC77112.1 - 2 8.1 10.0 0.092 12.4 2.5 2.8 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain Diphthamide_syn PF01866.17 EMC77113.1 - 7.9e-109 363.7 0.0 9.5e-109 363.5 0.0 1.0 1 0 0 1 1 1 1 Putative diphthamide synthesis protein EST1_DNA_bind PF10373.9 EMC77114.1 - 1.2e-59 202.2 0.4 4.9e-59 200.1 0.0 2.0 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain PIN_4 PF13638.6 EMC77114.1 - 1.8e-20 73.6 3.3 2.2e-20 73.3 0.0 2.9 2 0 0 2 2 2 1 PIN domain EST1 PF10374.9 EMC77114.1 - 1.2e-14 55.1 0.4 1.2e-14 55.1 0.4 2.9 3 0 0 3 3 3 1 Telomerase activating protein Est1 PIN_9 PF18477.1 EMC77114.1 - 0.0016 18.7 0.4 0.19 12.0 0.0 3.2 3 0 0 3 3 3 1 PIN like domain TPR_2 PF07719.17 EMC77114.1 - 0.42 10.8 1.8 5.5 7.4 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat PALP PF00291.25 EMC77115.1 - 2.3e-72 243.9 1.1 2.8e-72 243.6 1.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Glyco_trans_4_4 PF13579.6 EMC77115.1 - 0.0012 19.4 1.1 0.038 14.4 0.2 2.9 1 1 2 3 3 3 1 Glycosyl transferase 4-like domain RIBIOP_C PF04950.12 EMC77116.1 - 2.2e-120 401.5 0.0 4e-120 400.7 0.0 1.4 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EMC77116.1 - 2.3e-21 75.7 0.0 5.4e-21 74.5 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain DUF525 PF04379.14 EMC77117.1 - 4.2e-27 94.2 0.1 7.2e-27 93.5 0.1 1.4 1 0 0 1 1 1 1 ApaG domain YccV-like PF08755.11 EMC77117.1 - 4.8e-13 49.5 0.5 2.3e-12 47.3 0.1 2.1 2 0 0 2 2 2 1 Hemimethylated DNA-binding protein YccV like Vma12 PF11712.8 EMC77118.1 - 2.1e-20 73.2 0.1 2.5e-20 73.0 0.1 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase MFS_1 PF07690.16 EMC77119.1 - 2e-06 27.0 13.9 2e-06 27.0 13.9 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Na_sulph_symp PF00939.19 EMC77120.1 - 5e-144 480.9 25.2 5.8e-144 480.6 25.2 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 EMC77120.1 - 8.4e-34 117.1 28.9 2.1e-20 73.2 2.1 3.1 2 1 1 3 3 3 2 Citrate transporter Forkhead PF00250.18 EMC77121.1 - 1.6e-34 118.0 1.6 1.6e-34 118.0 0.2 1.8 2 0 0 2 2 2 1 Forkhead domain GMP_PDE_delta PF05351.11 EMC77122.1 - 3.6e-79 264.3 3.4 4e-79 264.1 3.4 1.0 1 0 0 1 1 1 1 GMP-PDE, delta subunit IIGP PF05049.13 EMC77122.1 - 0.071 12.1 0.2 0.096 11.7 0.2 1.1 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Glycolytic PF00274.19 EMC77123.1 - 5.6e-174 577.8 0.0 6.8e-174 577.6 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I Pox_A_type_inc PF04508.12 EMC77124.1 - 0.011 15.6 0.3 0.052 13.4 0.0 2.3 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Paramyx_P_V_C PF03210.13 EMC77124.1 - 0.034 13.9 0.2 0.053 13.3 0.2 1.3 1 0 0 1 1 1 0 Paramyxovirus P/V phosphoprotein C-terminal FAM184 PF15665.5 EMC77124.1 - 0.088 12.6 7.9 0.1 12.4 7.9 1.2 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B SAB PF04382.13 EMC77124.1 - 0.15 12.2 0.2 0.15 12.2 0.2 2.0 2 0 0 2 2 2 0 SAB domain ATG16 PF08614.11 EMC77124.1 - 0.7 10.1 14.5 0.86 9.8 14.5 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) APG6_N PF17675.1 EMC77124.1 - 0.73 10.4 14.8 2.1 8.9 14.8 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region Fib_alpha PF08702.10 EMC77124.1 - 3.8 7.7 7.6 43 4.3 7.1 2.0 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family GAS PF13851.6 EMC77125.1 - 0.056 12.8 8.0 0.07 12.5 8.0 1.0 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding NUDE_C PF04880.13 EMC77125.1 - 0.14 12.6 3.4 0.22 12.0 3.4 1.5 1 1 0 1 1 1 0 NUDE protein, C-terminal conserved region VPS11_C PF12451.8 EMC77125.1 - 5.7 7.2 7.8 2.9 8.2 0.6 2.5 2 1 0 2 2 2 0 Vacuolar protein sorting protein 11 C terminal Pkinase PF00069.25 EMC77126.1 - 8.7e-39 133.5 0.0 9.4e-39 133.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC77126.1 - 5.5e-18 65.2 0.0 6.2e-18 65.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC77126.1 - 3.4e-06 26.6 0.1 1.2e-05 24.8 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EMC77126.1 - 0.0013 17.7 0.1 0.0013 17.7 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EMC77126.1 - 0.0017 17.7 0.3 0.0021 17.5 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMC77126.1 - 0.003 16.4 0.1 0.0042 15.9 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Seadorna_VP7 PF07387.11 EMC77126.1 - 0.025 13.7 0.0 0.09 11.8 0.0 1.7 2 0 0 2 2 2 0 Seadornavirus VP7 APH PF01636.23 EMC77126.1 - 0.05 13.5 0.2 0.06 13.3 0.2 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family MIR PF02815.19 EMC77127.1 - 4.8e-06 26.5 0.1 3.7e-05 23.7 0.0 1.9 1 1 1 2 2 2 2 MIR domain YjbF PF11102.8 EMC77127.1 - 0.13 12.0 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 Group 4 capsule polysaccharide lipoprotein gfcB, YjbF SH2_2 PF14633.6 EMC77128.1 - 9.6e-85 283.4 0.3 9.6e-85 283.4 0.3 2.1 2 0 0 2 2 2 1 SH2 domain YqgF PF14639.6 EMC77128.1 - 2.4e-71 238.4 0.0 6.5e-71 237.0 0.0 1.8 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HHH_7 PF14635.6 EMC77128.1 - 2e-50 169.5 0.1 4.7e-50 168.3 0.1 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif HTH_44 PF14641.6 EMC77128.1 - 6.6e-26 91.0 3.0 2e-25 89.4 3.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.6 EMC77128.1 - 1e-15 58.0 26.8 1e-15 58.0 26.8 8.0 7 1 2 9 9 7 2 Acidic N-terminal SPT6 Tex_N PF09371.10 EMC77128.1 - 1.4e-08 34.6 0.0 0.0045 16.7 0.0 3.1 2 1 0 2 2 2 2 Tex-like protein N-terminal domain HHH_3 PF12836.7 EMC77128.1 - 1.6e-07 31.5 0.0 4.6e-07 30.0 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif S1 PF00575.23 EMC77128.1 - 2e-06 28.1 0.1 5.7e-06 26.6 0.1 1.8 1 0 0 1 1 1 1 S1 RNA binding domain SH2 PF00017.24 EMC77128.1 - 4.1e-06 26.8 0.0 1.2e-05 25.3 0.0 1.9 1 0 0 1 1 1 1 SH2 domain HHH_9 PF17674.1 EMC77128.1 - 1.1e-05 26.2 0.1 7.7e-05 23.5 0.1 2.7 1 0 0 1 1 1 1 HHH domain Tex_YqgF PF16921.5 EMC77128.1 - 0.00026 21.5 0.0 0.00054 20.4 0.0 1.5 1 0 0 1 1 1 1 Tex protein YqgF-like domain zf-Sec23_Sec24 PF04810.15 EMC77128.1 - 0.16 12.1 0.2 0.47 10.6 0.2 1.7 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger Phospholip_A2_2 PF05826.12 EMC77129.1 - 9.1e-20 70.7 2.2 1.7e-19 69.8 2.2 1.4 1 0 0 1 1 1 1 Phospholipase A2 SR-25 PF10500.9 EMC77129.1 - 0.21 11.1 12.7 0.1 12.2 4.6 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Phospholip_A2_1 PF00068.19 EMC77129.1 - 1.7 9.1 16.8 4.7 7.7 11.8 2.6 2 1 0 2 2 2 0 Phospholipase A2 Ribosomal_L23eN PF03939.13 EMC77130.1 - 1e-19 70.5 12.4 1e-19 70.5 12.4 1.7 2 0 0 2 2 2 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 EMC77130.1 - 2.2e-16 60.0 3.1 2.2e-16 60.0 3.1 2.6 2 1 0 2 2 2 1 Ribosomal protein L23 Ribosomal_L6 PF00347.23 EMC77130.1 - 0.048 14.3 1.8 0.054 14.2 0.1 1.9 2 0 0 2 2 2 0 Ribosomal protein L6 zf-ISL3 PF14690.6 EMC77130.1 - 0.16 12.6 1.6 0.41 11.4 1.6 1.6 1 0 0 1 1 1 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 TRAM_LAG1_CLN8 PF03798.16 EMC77131.1 - 5.6e-17 62.1 13.5 6.7e-17 61.9 13.5 1.1 1 0 0 1 1 1 1 TLC domain Pkinase PF00069.25 EMC77132.1 - 3.3e-65 220.1 0.0 4.7e-65 219.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RCC1 PF00415.18 EMC77132.1 - 8.3e-52 173.6 20.6 2.9e-12 47.0 0.8 8.1 7 1 1 8 8 8 5 Regulator of chromosome condensation (RCC1) repeat Pkinase_Tyr PF07714.17 EMC77132.1 - 4.4e-45 154.0 0.0 8.4e-45 153.1 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase RCC1_2 PF13540.6 EMC77132.1 - 1.8e-19 69.0 30.4 6.6e-06 25.8 0.2 6.8 7 1 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat Kinase-like PF14531.6 EMC77132.1 - 0.00015 21.2 0.0 0.00023 20.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EMC77132.1 - 0.00023 20.3 0.4 0.00038 19.5 0.4 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EMC77132.1 - 0.012 15.5 1.0 0.098 12.6 0.8 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EMC77132.1 - 0.1 11.3 0.1 0.15 10.8 0.1 1.2 1 0 0 1 1 1 0 Fungal protein kinase FAM222A PF15258.6 EMC77133.1 - 6.4e-280 929.7 39.4 7.2e-280 929.6 39.4 1.0 1 0 0 1 1 1 1 Protein family of FAM222A MMR_HSR1 PF01926.23 EMC77134.1 - 1.8e-21 76.4 0.0 2.7e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EMC77134.1 - 7.2e-11 42.4 0.2 7.2e-06 26.2 0.0 2.3 2 0 0 2 2 2 2 Dynamin family FeoB_N PF02421.18 EMC77134.1 - 7.9e-10 38.5 0.0 1.2e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.16 EMC77134.1 - 1.1e-08 34.7 0.0 2.3e-08 33.6 0.0 1.5 1 1 1 2 2 2 1 AIG1 family GTP_EFTU PF00009.27 EMC77134.1 - 1.6e-08 34.3 0.0 0.00031 20.3 0.0 2.7 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain KH_2 PF07650.17 EMC77134.1 - 3.3e-07 30.0 0.0 5.9e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 KH domain RsgA_GTPase PF03193.16 EMC77134.1 - 1.1e-06 28.7 0.9 0.0017 18.3 0.1 2.5 3 0 0 3 3 3 2 RsgA GTPase Ras PF00071.22 EMC77134.1 - 5.7e-05 22.8 0.0 0.00019 21.1 0.0 1.7 1 1 0 1 1 1 1 Ras family cobW PF02492.19 EMC77134.1 - 0.00042 20.0 0.3 0.0028 17.3 0.1 1.9 1 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.17 EMC77134.1 - 0.001 18.9 0.2 0.0074 16.1 0.1 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_28 PF13521.6 EMC77134.1 - 0.0011 19.2 0.0 0.016 15.5 0.0 2.1 1 1 1 2 2 2 1 AAA domain GBP PF02263.19 EMC77134.1 - 0.0027 17.0 0.1 0.07 12.4 0.2 2.5 2 1 0 2 2 2 1 Guanylate-binding protein, N-terminal domain G-alpha PF00503.20 EMC77134.1 - 0.0032 16.7 0.1 1.5 7.9 0.1 2.1 2 0 0 2 2 2 2 G-protein alpha subunit Arf PF00025.21 EMC77134.1 - 0.0059 16.1 0.3 0.075 12.5 0.3 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EMC77134.1 - 0.0062 16.7 0.0 0.066 13.4 0.0 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase KH_1 PF00013.29 EMC77134.1 - 0.0094 15.8 0.1 0.018 14.8 0.1 1.4 1 0 0 1 1 1 1 KH domain SRPRB PF09439.10 EMC77134.1 - 0.05 13.0 0.0 0.094 12.1 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_18 PF13238.6 EMC77134.1 - 0.13 12.8 0.0 0.27 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Band_7 PF01145.25 EMC77135.1 - 4.8e-20 72.3 0.1 4.8e-20 72.3 0.1 2.4 2 1 0 2 2 2 1 SPFH domain / Band 7 family Flot PF15975.5 EMC77135.1 - 2.1e-05 24.7 6.8 2.1e-05 24.7 6.8 3.5 2 2 1 3 3 3 1 Flotillin DUF1492 PF07374.11 EMC77135.1 - 1.1 9.5 6.6 0.35 11.1 3.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1492) YjbH PF06082.11 EMC77135.1 - 1.1 8.0 6.4 1.4 7.6 6.4 1.2 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH Band_7_1 PF13421.6 EMC77135.1 - 2.3 7.9 6.0 0.24 11.1 0.2 2.1 2 1 0 2 2 2 0 SPFH domain-Band 7 family PHF12_MRG_bd PF16737.5 EMC77136.1 - 1.1e-18 66.6 1.4 1.1e-18 66.6 1.4 1.8 2 0 0 2 2 2 1 PHD finger protein 12 MRG binding domain PHD PF00628.29 EMC77136.1 - 4.5e-07 29.7 3.8 4.5e-07 29.7 3.8 3.4 4 0 0 4 4 4 1 PHD-finger FHA PF00498.26 EMC77136.1 - 0.00025 21.3 0.0 0.00089 19.6 0.0 2.0 1 0 0 1 1 1 1 FHA domain C1_1 PF00130.22 EMC77136.1 - 0.0022 17.8 1.6 0.009 15.9 1.6 2.0 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_2 PF13831.6 EMC77136.1 - 0.065 12.8 0.1 0.065 12.8 0.1 4.5 5 0 0 5 5 5 0 PHD-finger Sushi PF00084.20 EMC77137.1 - 6.6e-31 106.7 13.2 1e-10 42.0 3.0 3.3 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) CUB PF00431.20 EMC77137.1 - 1.5e-15 57.5 0.0 1.7e-14 54.1 0.0 2.3 2 0 0 2 2 2 1 CUB domain cEGF PF12662.7 EMC77137.1 - 0.097 12.6 11.7 1.4 8.9 0.2 3.9 3 1 0 3 3 3 0 Complement Clr-like EGF-like SKG6 PF08693.10 EMC77137.1 - 0.12 11.8 0.9 0.23 10.9 0.9 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Parecho_VpG PF06344.11 EMC77138.1 - 0.038 14.5 1.0 8.1 7.3 0.1 4.0 3 1 0 3 3 3 0 Parechovirus Genome-linked protein AF-4 PF05110.13 EMC77139.1 - 0.019 13.1 23.5 0.027 12.6 23.5 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Rrn6 PF10214.9 EMC77139.1 - 0.065 11.7 14.2 0.056 11.9 14.2 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Rtf2 PF04641.12 EMC77139.1 - 0.16 11.3 18.6 0.24 10.7 18.6 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger SAPS PF04499.15 EMC77139.1 - 0.17 10.7 3.5 0.15 10.8 3.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein TFIIF_alpha PF05793.12 EMC77139.1 - 0.5 8.9 30.4 0.73 8.4 30.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) GREB1 PF15782.5 EMC77139.1 - 1.1 6.3 9.5 1.2 6.2 9.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SpoIIIAH PF12685.7 EMC77139.1 - 1.4 8.7 13.3 2.2 8.0 13.3 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein Paramyxo_ncap PF00973.19 EMC77139.1 - 1.7 7.4 8.5 2.1 7.2 8.5 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Menin PF05053.13 EMC77139.1 - 1.9 6.8 8.7 2.1 6.6 8.7 1.1 1 0 0 1 1 1 0 Menin DUF4551 PF15087.6 EMC77139.1 - 2.5 6.8 8.8 2.4 6.9 8.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Macoilin PF09726.9 EMC77139.1 - 3.3 6.2 20.2 4.4 5.8 20.2 1.1 1 0 0 1 1 1 0 Macoilin family Miga PF10265.9 EMC77139.1 - 5.8 5.8 16.0 7.1 5.5 16.0 1.1 1 0 0 1 1 1 0 Mitoguardin Paf1 PF03985.13 EMC77139.1 - 6.6 5.6 17.3 10 5.0 17.3 1.3 1 0 0 1 1 1 0 Paf1 SLC12 PF03522.15 EMC77139.1 - 7.2 5.5 12.4 9 5.2 12.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 NPR3 PF03666.13 EMC77139.1 - 8.6 5.0 20.9 11 4.7 20.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SOG2 PF10428.9 EMC77139.1 - 9 5.4 17.7 12 5.0 17.7 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein CCDC106 PF15794.5 EMC77139.1 - 9.5 5.9 32.9 1.1 9.0 21.6 2.1 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 106 Crystall PF00030.19 EMC77140.1 - 3.2e-31 107.4 0.3 3.8e-31 107.1 0.3 1.1 1 0 0 1 1 1 1 Beta/Gamma crystallin Inhibitor_I36 PF03995.13 EMC77140.1 - 0.047 13.6 0.0 0.096 12.6 0.0 1.6 1 1 0 1 1 1 0 Peptidase inhibitor family I36 IL4_i_Ig PF18258.1 EMC77140.1 - 0.073 13.3 0.1 13 6.1 0.0 2.2 1 1 1 2 2 2 0 Interleukin-4 inducing immunoglobulin-binding domain NUFIP2 PF15293.6 EMC77141.1 - 4.2e-303 1006.8 23.6 4.8e-303 1006.6 23.6 1.0 1 0 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 2 Pkinase PF00069.25 EMC77142.1 - 3.1e-65 220.2 0.0 3.1e-65 220.2 0.0 2.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC77142.1 - 2.3e-44 151.6 1.2 4.9e-44 150.6 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EMC77142.1 - 0.022 14.7 3.2 0.027 14.4 0.0 2.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family TcdB_N PF12918.7 EMC77142.1 - 4.7 7.6 14.1 2 8.8 5.3 4.0 3 0 0 3 3 3 0 TcdB toxin N-terminal helical domain GPCR_chapero_1 PF11904.8 EMC77144.1 - 5.7e-103 344.6 0.0 6.9e-103 344.3 0.0 1.1 1 0 0 1 1 1 1 GPCR-chaperone Ank_2 PF12796.7 EMC77144.1 - 9.4e-10 39.0 0.0 1.9e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC77144.1 - 1.7e-08 34.8 0.0 3.6e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC77144.1 - 2.5e-07 30.8 0.0 5.8e-07 29.7 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EMC77144.1 - 1e-06 28.9 0.0 4.3e-06 26.9 0.1 2.1 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 EMC77144.1 - 3.2e-06 27.0 0.0 0.00066 19.9 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat UIM PF02809.20 EMC77144.1 - 2.6 8.2 12.8 0.71 9.9 2.1 3.0 3 0 0 3 3 3 0 Ubiquitin interaction motif DSPc PF00782.20 EMC77146.1 - 2.5e-34 118.0 0.0 8.8e-34 116.2 0.0 2.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DEK_C PF08766.11 EMC77146.1 - 4.7e-11 42.4 5.1 1e-10 41.4 5.1 1.6 1 0 0 1 1 1 1 DEK C terminal domain Y_phosphatase PF00102.27 EMC77146.1 - 0.03 13.9 0.0 0.082 12.5 0.0 1.7 1 0 0 1 1 1 0 Protein-tyrosine phosphatase EF-hand_6 PF13405.6 EMC77147.1 - 0.00039 20.1 0.3 0.0025 17.6 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 EMC77147.1 - 0.00044 20.6 0.2 0.024 15.1 0.1 2.8 2 0 0 2 2 2 1 EF-hand domain pair Tfb2 PF03849.14 EMC77147.1 - 0.0092 15.0 0.7 4 6.3 0.0 3.0 3 0 0 3 3 3 2 Transcription factor Tfb2 YukC PF10140.9 EMC77147.1 - 0.011 14.6 0.3 0.011 14.6 0.3 1.8 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukC EF-hand_1 PF00036.32 EMC77147.1 - 0.017 14.6 0.0 0.071 12.7 0.0 2.2 1 0 0 1 1 1 0 EF hand SelB-wing_2 PF09106.11 EMC77147.1 - 0.07 13.3 0.2 0.67 10.2 0.1 2.5 2 0 0 2 2 2 0 Elongation factor SelB, winged helix EF-hand_5 PF13202.6 EMC77147.1 - 0.26 10.8 1.7 1.1 8.9 0.1 2.7 3 0 0 3 3 3 0 EF hand SPARC_Ca_bdg PF10591.9 EMC77147.1 - 0.51 10.7 2.7 0.58 10.5 0.9 1.9 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF2040 PF09745.9 EMC77148.1 - 4.8e-38 129.9 25.7 4.8e-38 129.9 25.7 5.6 2 1 3 5 5 5 1 Coiled-coil domain-containing protein 55 (DUF2040) SNF PF00209.18 EMC77149.1 - 4.2e-227 755.0 36.5 4.8e-227 754.8 36.5 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family 5HT_transport_N PF03491.13 EMC77149.1 - 2.9e-07 30.6 2.2 6.6e-07 29.4 2.2 1.6 1 0 0 1 1 1 1 Serotonin (5-HT) neurotransmitter transporter, N-terminus Peptidase_C1_2 PF03051.15 EMC77150.1 - 3.8e-194 645.5 3.5 4.3e-194 645.3 3.5 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 EMC77150.1 - 8.2e-07 29.3 1.4 0.0089 16.1 0.1 2.8 3 0 0 3 3 3 2 Papain family cysteine protease Ig_2 PF13895.6 EMC77151.1 - 2.8e-20 72.4 4.4 1.2e-14 54.4 0.9 2.1 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 EMC77151.1 - 9.9e-19 67.3 6.0 3.2e-12 46.4 1.5 2.1 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 EMC77151.1 - 1.6e-18 67.1 5.0 1.6e-13 51.1 1.2 2.2 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC77151.1 - 1.9e-16 59.9 3.8 9.7e-15 54.4 1.2 2.3 1 1 1 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 EMC77151.1 - 3.5e-12 46.4 7.4 8.9e-09 35.5 2.1 4.0 2 2 1 3 3 3 1 Immunoglobulin V-set domain Ig_4 PF16680.5 EMC77151.1 - 4.3e-06 26.9 3.9 0.0064 16.7 2.2 2.7 2 1 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 EMC77151.1 - 7e-06 26.0 4.2 0.0011 18.9 1.1 3.0 2 1 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 EMC77151.1 - 2e-05 24.0 0.1 0.23 11.1 0.0 2.8 3 0 0 3 3 3 2 Immunoglobulin domain Izumo-Ig PF16706.5 EMC77151.1 - 0.00074 19.5 1.2 0.0025 17.9 0.5 2.0 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 EMC77151.1 - 0.012 16.0 5.5 0.17 12.3 1.2 3.3 2 2 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_C17orf99 PF17736.1 EMC77151.1 - 0.059 13.4 0.2 0.3 11.2 0.0 2.1 2 1 0 2 2 2 0 C17orf99 Ig domain Invasin_D3 PF09134.10 EMC77151.1 - 0.1 12.9 0.3 0.9 9.9 0.0 2.3 1 1 1 2 2 2 0 Invasin, domain 3 V-SNARE_C PF12352.8 EMC77152.1 - 6.9e-22 77.5 3.6 6.9e-22 77.5 3.6 2.5 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EMC77152.1 - 0.0029 17.5 1.1 0.017 15.0 0.2 2.2 2 0 0 2 2 2 1 Sec20 Muted PF14942.6 EMC77152.1 - 0.08 13.3 3.6 1.7 9.0 2.0 2.2 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein Abi_C PF14355.6 EMC77152.1 - 0.091 12.9 0.1 1.9 8.7 0.0 2.4 2 0 0 2 2 2 0 Abortive infection C-terminus DUF1664 PF07889.12 EMC77152.1 - 0.12 12.4 1.6 0.23 11.5 0.5 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) HLH PF00010.26 EMC77153.1 - 4.1e-09 36.3 2.6 6.7e-09 35.6 2.6 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain RhoGEF PF00621.20 EMC77154.1 - 1.5e-29 103.6 1.8 1.5e-29 103.5 0.3 1.8 2 1 0 2 2 2 1 RhoGEF domain PH PF00169.29 EMC77154.1 - 8.2e-11 42.4 1.8 7.9e-10 39.2 1.8 2.2 1 1 0 1 1 1 1 PH domain Phage_antiter_Q PF06323.11 EMC77154.1 - 0.0074 15.8 0.1 0.014 15.0 0.1 1.3 1 0 0 1 1 1 1 Phage antitermination protein Q PH_10 PF15411.6 EMC77154.1 - 0.26 11.5 0.1 0.26 11.5 0.1 1.7 2 0 0 2 2 2 0 Pleckstrin homology domain Tim17 PF02466.19 EMC77155.1 - 9.9e-30 103.2 7.0 1.2e-29 102.9 7.0 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family CH PF00307.31 EMC77156.1 - 7.1e-22 77.7 0.0 2.4e-21 75.9 0.0 2.0 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EMC77156.1 - 6e-06 26.0 0.1 2.1e-05 24.3 0.0 2.1 2 0 0 2 2 2 1 CAMSAP CH domain Hormone_6 PF00236.18 EMC77156.1 - 0.053 13.5 0.0 0.17 11.8 0.0 1.8 1 0 0 1 1 1 0 Glycoprotein hormone DUF5475 PF17569.2 EMC77156.1 - 0.1 12.9 0.8 0.29 11.5 0.8 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5475) 7tm_1 PF00001.21 EMC77157.1 - 5.7e-54 183.2 17.0 7.1e-54 182.9 17.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC77157.1 - 1.1e-12 48.3 18.2 1.5e-12 47.8 18.2 1.1 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 EMC77157.1 - 1.4e-12 47.6 18.8 2.2e-08 33.8 5.1 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC77157.1 - 3.3e-06 26.9 18.3 3.3e-06 26.9 18.3 2.6 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx GPR_Gpa2_C PF11970.8 EMC77157.1 - 0.0072 16.4 0.3 0.027 14.5 0.3 2.1 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term SWIM PF04434.17 EMC77158.1 - 7.3e-07 28.7 3.1 1.1e-06 28.1 3.1 1.4 1 0 0 1 1 1 1 SWIM zinc finger TPR_12 PF13424.6 EMC77159.1 - 4.2e-24 84.6 17.2 3.7e-12 46.4 0.7 4.3 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 EMC77159.1 - 1.2e-13 50.4 12.4 0.026 14.4 0.1 6.3 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_MalT PF17874.1 EMC77159.1 - 3.4e-13 49.7 14.7 1.7e-06 27.6 1.0 2.6 1 1 0 2 2 2 2 MalT-like TPR region TPR_2 PF07719.17 EMC77159.1 - 6.3e-13 47.8 15.1 0.0045 17.0 0.4 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 EMC77159.1 - 2.9e-11 42.7 15.3 0.007 16.1 0.5 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 EMC77159.1 - 2e-09 36.9 16.1 0.052 13.8 0.5 5.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 EMC77159.1 - 6.3e-07 29.0 11.7 0.028 14.4 0.2 5.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 EMC77159.1 - 9.3e-07 29.2 14.6 0.41 11.6 0.4 6.1 3 2 3 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMC77159.1 - 3.5e-06 27.4 19.0 0.0062 17.0 3.8 4.1 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_16 PF13432.6 EMC77159.1 - 2.1e-05 25.1 5.8 0.0082 16.8 0.9 4.4 4 1 0 4 4 4 1 Tetratricopeptide repeat ComR_TPR PF18710.1 EMC77159.1 - 4.8e-05 23.0 4.8 4.8e-05 23.0 4.8 2.6 2 1 0 2 2 2 1 ComR tetratricopeptide TPR_17 PF13431.6 EMC77159.1 - 0.00015 21.9 9.4 1.8 9.2 0.0 6.1 5 2 0 5 5 5 2 Tetratricopeptide repeat TPR_4 PF07721.14 EMC77159.1 - 0.0027 18.1 0.0 2.9 8.8 0.0 4.0 4 0 0 4 4 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC77159.1 - 0.017 15.3 11.5 0.35 11.1 0.1 3.9 2 2 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 ANAPC5 PF12862.7 EMC77159.1 - 0.058 13.5 11.2 0.081 13.0 0.8 3.4 2 2 1 3 3 3 0 Anaphase-promoting complex subunit 5 TPR_21 PF09976.9 EMC77159.1 - 0.061 13.0 17.6 0.3 10.8 6.6 2.8 2 2 0 2 2 2 0 Tetratricopeptide repeat-like domain PPR PF01535.20 EMC77159.1 - 0.18 12.1 1.0 4.3 7.8 0.1 3.5 4 0 0 4 4 4 0 PPR repeat T3SS_basalb_I PF17001.5 EMC77159.1 - 1.3 9.7 8.6 1.8 9.2 2.3 2.9 2 1 0 2 2 2 0 Type III secretion basal body protein I, YscI, HrpB, PscI LsmAD PF06741.13 EMC77159.1 - 1.4 9.5 3.9 2 9.0 0.0 2.9 3 1 0 3 3 3 0 LsmAD domain Complex1_LYR_2 PF13233.6 EMC77159.1 - 3.3 8.5 5.8 11 6.8 5.7 2.0 1 1 0 1 1 1 0 Complex1_LYR-like MIT PF04212.18 EMC77159.1 - 7.8 6.6 16.1 2.7 8.1 0.4 4.9 5 1 1 6 6 6 0 MIT (microtubule interacting and transport) domain GPS2_interact PF15784.5 EMC77160.1 - 9.7e-36 122.1 5.0 9.7e-36 122.1 5.0 6.7 8 0 0 8 8 8 1 G-protein pathway suppressor 2-interacting domain Myb_DNA-binding PF00249.31 EMC77160.1 - 6.5e-17 61.4 0.3 2.1e-12 47.0 0.2 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EMC77160.1 - 0.0025 18.0 2.3 0.065 13.5 0.3 3.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain PIG-L PF02585.17 EMC77161.1 - 7.5e-11 42.8 0.0 2.3e-10 41.2 0.0 1.7 2 0 0 2 2 2 1 GlcNAc-PI de-N-acetylase GFA PF04828.14 EMC77162.1 - 5.5e-10 39.5 1.2 5.5e-10 39.5 1.2 1.5 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Ery_res_leader1 PF08051.11 EMC77163.1 - 0.033 14.2 1.9 83 3.9 0.1 4.3 4 0 0 4 4 4 0 Erythromycin resistance leader peptide Glyco_hydro_65C PF03633.15 EMC77163.1 - 0.034 14.1 0.0 9.1 6.3 0.0 3.5 4 0 0 4 4 4 0 Glycosyl hydrolase family 65, C-terminal domain ubiquitin PF00240.23 EMC77164.1 - 1.2e-133 435.0 15.4 4.2e-34 116.1 0.3 4.0 4 0 0 4 4 4 4 Ubiquitin family Rad60-SLD PF11976.8 EMC77164.1 - 2.4e-64 213.1 16.3 4.5e-16 58.4 0.4 4.0 4 0 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EMC77164.1 - 3.8e-25 88.1 5.9 0.00011 22.6 0.1 5.6 4 4 0 4 4 4 4 Ubiquitin-like domain TBK1_ULD PF18396.1 EMC77164.1 - 4.3e-17 61.8 1.8 0.021 14.7 0.0 4.2 4 0 0 4 4 4 4 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EMC77164.1 - 6.5e-15 55.2 2.1 0.068 13.3 0.0 5.1 4 4 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EMC77164.1 - 2.2e-13 50.4 6.4 0.045 14.1 0.1 4.1 4 0 0 4 4 4 4 Ubiquitin-like domain DUF2407 PF10302.9 EMC77164.1 - 2.7e-12 47.2 0.2 0.51 10.9 0.0 4.2 1 1 2 4 4 4 4 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 EMC77164.1 - 9.1e-07 28.8 0.1 2.2 8.1 0.0 3.8 1 1 3 4 4 4 3 Silencing defective 2 N-terminal ubiquitin domain Methyltrans_RNA PF04452.14 EMC77164.1 - 3e-06 26.7 0.3 1.9 7.8 0.0 3.2 3 0 0 3 3 3 3 RNA methyltransferase Ubiquitin_4 PF18036.1 EMC77164.1 - 5.9e-06 26.3 19.4 23 5.1 0.2 7.4 7 1 0 7 7 7 0 Ubiquitin-like domain DUF2870 PF11069.8 EMC77164.1 - 1.3e-05 25.5 0.0 28 5.2 0.0 4.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2870) UDP-g_GGTase PF06427.11 EMC77164.1 - 1.7e-05 24.9 2.5 5.1 7.3 0.0 3.9 4 0 0 4 4 4 3 UDP-glucose:Glycoprotein Glucosyltransferase RBD PF02196.15 EMC77164.1 - 2.5e-05 24.3 0.0 32 4.7 0.0 4.3 4 0 0 4 4 4 0 Raf-like Ras-binding domain DUF3861 PF12977.7 EMC77164.1 - 0.00014 22.0 1.2 39 4.5 0.0 4.2 4 0 0 4 4 4 0 Domain of Unknown Function with PDB structure (DUF3861) Big_7 PF17957.1 EMC77164.1 - 0.0014 19.3 0.0 1.3e+02 3.4 0.0 4.1 4 0 0 4 4 4 0 Bacterial Ig domain DUF969 PF06149.12 EMC77164.1 - 0.0024 17.3 0.1 20 4.5 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF969) GDYXXLXY PF14345.6 EMC77164.1 - 0.006 16.4 0.1 1e+02 2.6 0.0 4.2 4 0 0 4 4 4 0 GDYXXLXY protein TraK PF06586.11 EMC77164.1 - 0.0083 15.8 0.2 86 2.7 0.0 3.9 4 0 0 4 4 4 0 TraK protein FlgD_ig PF13860.6 EMC77164.1 - 0.0086 15.9 5.5 54 3.7 0.1 4.3 4 0 0 4 4 4 0 FlgD Ig-like domain CorA PF01544.18 EMC77164.1 - 0.0087 15.4 0.2 73 2.5 0.0 3.9 4 0 0 4 4 4 0 CorA-like Mg2+ transporter protein ORF11CD3 PF10549.9 EMC77164.1 - 0.011 15.8 0.0 85 3.4 0.0 4.1 3 0 0 3 3 3 0 ORF11CD3 domain ProRS-C_2 PF09181.10 EMC77164.1 - 0.031 14.4 3.1 1.2e+02 2.9 0.0 4.1 4 0 0 4 4 4 0 Prolyl-tRNA synthetase, C-terminal Phage_sheath_1N PF17481.2 EMC77164.1 - 0.035 14.6 3.7 1.2e+02 3.2 3.7 3.9 1 1 0 1 1 1 0 Phage tail sheath protein beta-sandwich domain DUF5450 PF17529.2 EMC77164.1 - 0.056 13.6 0.0 1.1e+02 2.8 0.0 3.5 4 0 0 4 4 4 0 Family of unknown function (DUF5450) PI3K_p85B PF02192.16 EMC77164.1 - 2.4 7.9 7.1 1.5e+02 2.2 0.1 4.1 4 0 0 4 4 4 0 PI3-kinase family, p85-binding domain Ion_trans PF00520.31 EMC77165.1 - 1.8e-11 43.7 20.5 2.6e-11 43.2 20.5 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 EMC77165.1 - 0.18 10.4 16.4 0.37 9.4 15.6 1.8 1 1 0 1 1 1 0 Polycystin cation channel Haspin_kinase PF12330.8 EMC77166.1 - 3.8e-84 282.7 0.1 4.7e-84 282.4 0.1 1.0 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase PF00069.25 EMC77166.1 - 1.7e-06 27.6 0.2 6.4e-06 25.7 0.1 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC77166.1 - 0.0027 17.0 0.1 0.013 14.8 0.1 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EMC77166.1 - 0.055 13.4 0.0 0.24 11.3 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family P2X_receptor PF00864.19 EMC77167.1 - 2.6e-121 405.2 0.1 2.9e-121 405.0 0.1 1.0 1 0 0 1 1 1 1 ATP P2X receptor WAP PF00095.21 EMC77167.1 - 2.4 8.6 5.6 0.66 10.4 1.3 2.2 2 0 0 2 2 2 0 WAP-type (Whey Acidic Protein) 'four-disulfide core' Rab5ip PF07019.12 EMC77168.1 - 3.8e-23 81.9 8.1 4.6e-23 81.6 8.1 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) DUF5084 PF16894.5 EMC77168.1 - 0.046 14.1 1.4 0.064 13.7 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5084) PDZ PF00595.24 EMC77169.1 - 3.5e-20 72.1 0.2 4.4e-20 71.8 0.2 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC77169.1 - 1.8e-11 44.2 0.3 2.5e-11 43.7 0.3 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC77169.1 - 3.9e-11 42.6 0.1 7.2e-11 41.8 0.1 1.5 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 EMC77169.1 - 0.13 12.6 0.1 0.23 11.8 0.0 1.4 2 0 0 2 2 2 0 GRASP55/65 PDZ-like domain FGGY_N PF00370.21 EMC77170.1 - 1.8e-25 90.0 0.1 3.3e-24 85.8 0.1 2.2 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 EMC77170.1 - 0.008 15.7 0.0 0.018 14.6 0.0 1.6 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family GBP_PSP PF02425.15 EMC77170.1 - 1.1 9.0 3.7 0.63 9.7 0.2 2.3 2 0 0 2 2 2 0 Paralytic/GBP/PSP peptide Ank_2 PF12796.7 EMC77171.1 - 1.2e-18 67.5 6.0 2.2e-08 34.5 0.9 3.8 2 2 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC77171.1 - 1.2e-12 46.8 0.2 0.0042 17.5 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 EMC77171.1 - 5.2e-12 45.6 0.1 0.049 14.1 0.0 4.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EMC77171.1 - 6.4e-10 39.1 0.1 0.061 13.7 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC77171.1 - 2.7e-09 37.4 0.1 0.026 15.1 0.0 5.0 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ion_trans PF00520.31 EMC77171.1 - 1.1e-08 34.6 18.1 2.1e-08 33.7 18.1 1.5 1 0 0 1 1 1 1 Ion transport protein AstE_AspA PF04952.14 EMC77172.1 - 1.6e-62 211.2 0.0 1.9e-62 211.0 0.0 1.0 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family TSKS PF15358.6 EMC77173.1 - 0.079 11.3 0.0 0.13 10.6 0.0 1.3 1 0 0 1 1 1 0 Testis-specific serine kinase substrate L_HMGIC_fpl PF10242.9 EMC77174.1 - 4.3e-14 53.1 0.4 5.2e-14 52.9 0.4 1.0 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein DUF1240 PF06836.12 EMC77174.1 - 0.088 13.4 0.1 0.11 13.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1240) Claudin_2 PF13903.6 EMC77174.1 - 0.1 12.3 0.2 0.11 12.2 0.2 1.1 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction RGS PF00615.19 EMC77175.1 - 6.4e-31 107.1 2.1 3e-12 46.9 0.1 3.5 3 0 0 3 3 3 3 Regulator of G protein signaling domain WD40 PF00400.32 EMC77176.1 - 2.7e-62 205.2 25.4 3.2e-09 37.3 0.1 9.1 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC77176.1 - 4e-25 87.9 5.1 3.4e-06 27.3 0.1 6.1 3 2 4 7 7 6 5 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 EMC77176.1 - 2.1e-13 50.6 0.2 5.2e-13 49.3 0.1 1.8 2 0 0 2 2 1 1 NLE (NUC135) domain eIF2A PF08662.11 EMC77176.1 - 2.3e-07 30.9 0.1 0.37 10.6 0.0 3.9 2 2 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EMC77176.1 - 7.6e-07 28.4 0.2 0.061 12.3 0.0 4.8 3 3 1 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EMC77176.1 - 1.7e-06 27.8 2.6 0.24 11.4 0.1 5.8 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Frtz PF11768.8 EMC77176.1 - 4.8e-05 21.9 0.0 0.057 11.7 0.0 3.0 2 1 1 3 3 3 3 WD repeat-containing and planar cell polarity effector protein Fritz Nup160 PF11715.8 EMC77176.1 - 0.00012 20.9 3.6 3.6 6.1 0.1 4.8 3 2 2 5 5 5 1 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 EMC77176.1 - 0.00058 18.5 0.0 0.073 11.6 0.0 2.9 3 0 0 3 3 3 1 Cytochrome D1 heme domain WD40_like PF17005.5 EMC77176.1 - 0.0026 17.2 0.0 15 4.8 0.0 4.1 4 0 0 4 4 4 0 WD40-like domain PALB2_WD40 PF16756.5 EMC77176.1 - 0.004 16.1 4.3 0.17 10.8 0.2 3.1 3 0 0 3 3 3 2 Partner and localizer of BRCA2 WD40 domain Nucleoporin_N PF08801.11 EMC77176.1 - 0.0074 15.1 1.6 5.7 5.6 0.0 3.8 3 1 1 4 4 4 1 Nup133 N terminal like FAD_binding_9 PF08021.11 EMC77176.1 - 0.014 15.6 0.0 0.035 14.3 0.0 1.7 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain Nbas_N PF15492.6 EMC77176.1 - 0.03 13.7 1.6 12 5.1 0.1 4.3 3 2 2 5 5 5 0 Neuroblastoma-amplified sequence, N terminal nos_propeller PF18764.1 EMC77176.1 - 0.21 11.5 0.3 16 5.5 0.0 3.7 3 1 1 4 4 4 0 Nitrous oxide reductase propeller repeat Pkinase PF00069.25 EMC77177.1 - 1.2e-70 237.9 0.1 3.6e-70 236.4 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC77177.1 - 3.2e-49 167.6 0.0 5.5e-49 166.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3543 PF12063.8 EMC77177.1 - 2e-25 89.6 2.8 3.8e-25 88.7 2.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Kdo PF06293.14 EMC77177.1 - 1.7e-07 30.8 0.0 4.5e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EMC77177.1 - 7.6e-06 25.7 0.1 1.4e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 EMC77177.1 - 0.00022 20.1 0.2 0.00053 18.9 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EMC77177.1 - 0.0043 16.4 0.0 0.02 14.2 0.0 2.0 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 EMC77177.1 - 0.0077 16.2 0.0 0.017 15.1 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Aldedh PF00171.22 EMC77178.1 - 6e-77 259.1 0.0 3.3e-49 167.6 0.0 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family Aldedh PF00171.22 EMC77179.1 - 3.7e-82 276.3 0.0 4.2e-82 276.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family MatE PF01554.18 EMC77181.1 - 1.6e-49 167.7 25.3 5.8e-30 104.1 10.9 2.2 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 EMC77181.1 - 5.7e-06 26.5 12.8 5.7e-06 26.5 12.8 3.0 2 2 0 2 2 2 1 Polysaccharide biosynthesis C-terminal domain 7tm_4 PF13853.6 EMC77183.1 - 2.1e-19 70.3 4.8 2.3e-19 70.2 4.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC77183.1 - 0.00087 18.7 7.6 0.0013 18.2 7.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC77184.1 - 2.6e-42 145.5 22.4 3.6e-42 145.0 22.4 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC77184.1 - 6.9e-22 78.0 23.2 9.7e-22 77.5 23.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC77184.1 - 1.5e-06 27.8 20.7 2.5e-06 27.1 20.4 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC77184.1 - 0.57 9.8 29.3 0.15 11.7 16.1 2.1 1 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx zf-C2H2 PF00096.26 EMC77185.1 - 4.9e-10 39.3 114.5 0.0013 19.1 7.9 14.4 14 0 0 14 14 14 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC77185.1 - 0.00097 19.8 129.3 0.13 13.2 6.3 15.8 15 0 0 15 15 15 9 C2H2-type zinc finger zf-met PF12874.7 EMC77185.1 - 0.013 15.9 1.3 0.013 15.9 1.3 9.4 10 0 0 10 10 10 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 EMC77185.1 - 0.013 15.9 2.7 0.013 15.9 2.7 11.6 10 1 0 10 10 10 0 Zinc-finger double domain FOXP-CC PF16159.5 EMC77185.1 - 0.093 13.4 56.6 1.8 9.3 0.1 11.9 9 3 4 13 13 13 0 FOXP coiled-coil domain Amino_oxidase PF01593.24 EMC77186.1 - 5.6e-136 454.4 0.0 4.2e-135 451.5 0.0 1.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase SWIRM PF04433.17 EMC77186.1 - 6.4e-18 64.9 0.3 3.6e-17 62.5 0.0 2.4 3 0 0 3 3 2 1 SWIRM domain NAD_binding_8 PF13450.6 EMC77186.1 - 4e-14 52.6 0.7 8.8e-14 51.5 0.7 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMC77186.1 - 6.7e-08 32.5 0.0 3.2e-07 30.2 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMC77186.1 - 4.1e-06 26.2 0.1 2e-05 24.0 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EMC77186.1 - 7.3e-06 25.4 0.4 2e-05 24.0 0.4 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 EMC77186.1 - 4.5e-05 22.7 1.0 8.6e-05 21.8 0.6 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 EMC77186.1 - 5.7e-05 23.6 0.2 5.7e-05 23.6 0.2 3.1 4 0 0 4 4 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EMC77186.1 - 0.00095 18.5 0.3 0.0017 17.7 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EMC77186.1 - 0.00097 17.9 0.4 0.00097 17.9 0.4 2.1 1 1 1 2 2 2 1 HI0933-like protein Thi4 PF01946.17 EMC77186.1 - 0.0015 17.8 0.1 0.0028 16.9 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 EMC77186.1 - 0.0016 17.8 0.2 0.015 14.6 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EMC77186.1 - 0.0062 15.9 2.3 0.0062 15.9 2.3 1.8 1 1 0 2 2 2 1 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.19 EMC77186.1 - 0.021 14.2 0.2 0.076 12.4 0.1 2.0 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GIDA PF01134.22 EMC77186.1 - 0.06 12.4 5.4 0.12 11.4 0.3 2.2 1 1 0 2 2 2 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EMC77186.1 - 0.11 11.5 0.1 0.2 10.7 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein MCRA PF06100.11 EMC77186.1 - 0.11 11.2 0.3 0.23 10.2 0.1 1.7 1 1 0 1 1 1 0 MCRA family IlvN PF07991.12 EMC77186.1 - 0.12 11.9 0.5 0.42 10.2 0.2 1.9 1 1 1 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain MutS_IV PF05190.18 EMC77186.1 - 0.17 12.3 3.1 1.6 9.1 0.6 2.6 2 0 0 2 2 2 0 MutS family domain IV DUF1180 PF06679.12 EMC77186.1 - 0.22 11.9 0.6 0.52 10.7 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Snapin_Pallidin PF14712.6 EMC77186.1 - 0.63 10.5 7.3 8 7.0 7.3 2.4 1 1 0 1 1 1 0 Snapin/Pallidin AATF-Che1 PF13339.6 EMC77186.1 - 0.82 10.4 6.3 1.6 9.4 4.9 2.2 2 1 0 2 2 2 0 Apoptosis antagonizing transcription factor DASH_Dad3 PF08656.10 EMC77186.1 - 0.86 9.7 3.9 8 6.6 0.1 2.9 3 0 0 3 3 3 0 DASH complex subunit Dad3 DUF4298 PF14131.6 EMC77186.1 - 3.6 7.6 8.2 3.5 7.7 0.7 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4298) MRPL52 PF18699.1 EMC77186.1 - 6 7.1 10.9 0.26 11.5 3.8 2.4 2 1 0 2 2 2 0 Mitoribosomal protein mL52 HD_assoc PF13286.6 EMC77187.1 - 0.028 15.0 0.3 0.13 12.8 0.3 2.2 1 0 0 1 1 1 0 Phosphohydrolase-associated domain Pantoate_ligase PF02569.15 EMC77187.1 - 0.41 9.8 5.3 1.2 8.3 5.3 1.8 1 0 0 1 1 1 0 Pantoate-beta-alanine ligase Trimer_CC PF08954.11 EMC77187.1 - 5.8 6.6 22.0 0.27 10.8 0.1 4.5 4 0 0 4 4 4 0 Trimerisation motif Pyocin_S PF06958.12 EMC77187.1 - 6.7 7.2 6.7 1.6 9.2 2.6 2.0 2 0 0 2 2 2 0 S-type Pyocin DASH_Dam1 PF08653.10 EMC77187.1 - 7.1 6.5 13.6 37 4.2 0.6 4.4 4 0 0 4 4 4 0 DASH complex subunit Dam1 DASH_Hsk3 PF08227.11 EMC77187.1 - 8.7 6.8 6.7 14 6.1 0.4 3.4 3 0 0 3 3 3 0 DASH complex subunit Hsk3 like 7tm_1 PF00001.21 EMC77188.1 - 2.1e-78 263.3 13.6 2.6e-78 263.0 13.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC77188.1 - 1.4e-11 44.3 9.2 3.5e-11 43.0 9.2 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC77188.1 - 2e-05 24.3 11.6 2e-05 24.3 11.6 2.0 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC77188.1 - 4.1e-05 23.5 14.8 0.0029 17.4 11.6 2.6 2 1 0 2 2 2 2 Olfactory receptor Ras PF00071.22 EMC77190.1 - 1.3e-50 171.2 0.1 1.5e-50 170.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC77190.1 - 1.7e-17 63.7 0.0 3.4e-17 62.8 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC77190.1 - 5.7e-07 29.1 0.0 8.2e-07 28.6 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC77190.1 - 0.00026 21.0 0.0 0.00053 20.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC77190.1 - 0.00051 20.0 2.1 0.5 10.3 0.2 2.3 1 1 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 EMC77190.1 - 0.0026 17.2 0.8 0.0098 15.3 0.8 1.8 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MeaB PF03308.16 EMC77190.1 - 0.0049 15.9 0.6 0.38 9.7 0.3 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 EMC77190.1 - 0.026 14.9 0.1 0.04 14.3 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 EMC77190.1 - 0.049 13.3 0.6 0.22 11.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EMC77190.1 - 0.079 13.2 0.3 0.36 11.1 0.3 2.2 1 1 0 1 1 1 0 AAA domain MMR_HSR1_Xtn PF16897.5 EMC77190.1 - 0.095 12.7 0.1 0.32 11.0 0.1 1.8 1 1 1 2 2 2 0 C-terminal region of MMR_HSR1 domain DUF2408 PF10303.9 EMC77190.1 - 0.11 13.0 5.3 2 9.0 5.1 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF2408) AAA_28 PF13521.6 EMC77190.1 - 0.15 12.3 0.1 0.34 11.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain p25-alpha PF05517.12 EMC77191.1 - 4.9e-67 224.9 5.6 5.6e-67 224.7 5.6 1.0 1 0 0 1 1 1 1 p25-alpha EF-hand_7 PF13499.6 EMC77191.1 - 0.029 14.8 0.0 0.07 13.6 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain pair FAST_1 PF06743.15 EMC77191.1 - 0.11 12.4 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 1 EF-hand_1 PF00036.32 EMC77191.1 - 0.15 11.7 0.9 0.87 9.3 0.0 2.7 3 0 0 3 3 3 0 EF hand ECH_1 PF00378.20 EMC77192.1 - 5.9e-23 81.5 0.0 6.4e-23 81.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EMC77192.1 - 0.0052 16.3 0.0 0.12 11.8 0.0 1.9 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Vert_IL3-reg_TF PF06529.11 EMC77193.1 - 4.4e-186 617.8 20.8 6.3e-186 617.2 20.8 1.2 1 0 0 1 1 1 1 Vertebrate interleukin-3 regulated transcription factor bZIP_2 PF07716.15 EMC77193.1 - 1.2e-14 54.1 9.6 1.2e-14 54.1 9.6 2.9 3 0 0 3 3 3 1 Basic region leucine zipper bZIP_1 PF00170.21 EMC77193.1 - 0.00026 21.0 7.1 0.00026 21.0 7.1 3.5 3 1 0 3 3 3 1 bZIP transcription factor Lectin_N PF03954.14 EMC77193.1 - 0.83 9.4 5.4 0.43 10.3 0.2 2.8 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain Pkinase_Tyr PF07714.17 EMC77194.1 - 1.6e-86 289.8 0.0 2.1e-86 289.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC77194.1 - 3.4e-37 128.2 0.0 4.9e-37 127.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kringle PF00051.18 EMC77194.1 - 1.4e-25 89.4 2.7 5.4e-25 87.5 2.5 2.1 2 0 0 2 2 2 1 Kringle domain I-set PF07679.16 EMC77194.1 - 6e-18 64.7 0.0 1.1e-17 63.8 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC77194.1 - 1.9e-15 57.2 2.1 2.1e-15 57.0 0.1 2.2 2 0 0 2 2 2 1 Immunoglobulin domain Fz PF01392.22 EMC77194.1 - 1.6e-11 44.8 2.7 1.6e-11 44.8 2.7 2.1 2 0 0 2 2 2 1 Fz domain Ig_2 PF13895.6 EMC77194.1 - 6.4e-09 36.0 0.0 2e-08 34.5 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC77194.1 - 2.8e-07 30.7 0.3 3.8e-05 23.8 0.3 2.4 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 EMC77194.1 - 5.6e-07 29.7 0.0 1.5e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain DUF2149 PF09919.9 EMC77194.1 - 0.13 12.5 0.0 0.33 11.2 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2149) TMEM154 PF15102.6 EMC77194.1 - 0.16 11.9 0.1 0.16 11.9 0.1 2.0 2 0 0 2 2 2 0 TMEM154 protein family Aminotran_1_2 PF00155.21 EMC77195.1 - 4.3e-42 144.6 0.0 4.9e-42 144.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II PAD PF03068.15 EMC77195.1 - 0.036 13.1 0.0 0.052 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) Cys_Met_Meta_PP PF01053.20 EMC77195.1 - 0.069 11.7 0.0 0.11 11.0 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme PBD PF00786.28 EMC77196.1 - 1.1e-05 25.7 0.1 1.5e-05 25.2 0.1 1.4 1 0 0 1 1 1 1 P21-Rho-binding domain Complex1_LYR PF05347.15 EMC77197.1 - 3.1e-08 33.5 0.6 5.7e-08 32.7 0.6 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) DUF2748 PF10871.8 EMC77197.1 - 0.016 13.8 0.7 0.02 13.5 0.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2748) DUF2570 PF10828.8 EMC77197.1 - 0.055 13.3 0.2 0.074 12.9 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) HIT PF01230.23 EMC77198.1 - 3.3e-25 88.7 0.0 3.6e-25 88.6 0.0 1.0 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EMC77198.1 - 6.1e-15 55.7 0.0 6.7e-15 55.6 0.0 1.0 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CHGN PF05679.16 EMC77199.1 - 2.7e-175 584.1 0.4 3e-175 583.9 0.4 1.0 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Glyco_transf_7C PF02709.14 EMC77199.1 - 3.3e-10 39.5 0.1 8.5e-10 38.2 0.1 1.7 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 EMC77199.1 - 3.8e-07 29.9 0.0 2e-06 27.5 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EMC77199.1 - 0.033 14.0 0.0 0.078 12.8 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 2 UPF0258 PF06789.12 EMC77200.1 - 1.6e-48 164.7 0.8 1.7e-48 164.6 0.8 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0258) ADAM_spacer1 PF05986.14 EMC77201.1 - 1.1e-29 102.8 0.0 2.3e-29 101.7 0.0 1.6 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Pep_M12B_propep PF01562.19 EMC77201.1 - 2e-21 76.7 0.0 4.6e-21 75.5 0.0 1.6 1 0 0 1 1 1 1 Reprolysin family propeptide TSP_1 PF00090.19 EMC77201.1 - 2.3e-21 75.7 96.3 4.3e-08 33.2 11.6 7.4 7 2 0 7 7 6 5 Thrombospondin type 1 domain ADAM_CR_2 PF17771.1 EMC77201.1 - 5.4e-21 74.9 8.8 5.4e-21 74.9 8.8 5.9 6 1 1 7 7 3 2 ADAM cysteine-rich domain Reprolysin PF01421.19 EMC77201.1 - 1.4e-19 70.8 1.6 1.4e-19 70.8 1.6 3.3 2 1 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.6 EMC77201.1 - 1.3e-12 48.3 0.6 3.4e-12 46.9 0.6 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EMC77201.1 - 4e-10 40.3 0.1 8.4e-10 39.2 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EMC77201.1 - 1.7e-06 28.0 0.1 4.9e-06 26.6 0.1 1.8 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EMC77201.1 - 1.7e-05 24.5 0.6 0.00015 21.5 0.6 2.1 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like PLAC PF08686.11 EMC77201.1 - 0.00038 21.1 7.0 0.0032 18.2 7.0 2.8 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain Peptidase_M10 PF00413.24 EMC77201.1 - 0.0009 19.1 0.3 0.0016 18.3 0.3 1.3 1 0 0 1 1 1 1 Matrixin DUF3810 PF12725.7 EMC77201.1 - 0.2 11.0 0.0 0.31 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) AMP-binding PF00501.28 EMC77202.1 - 7.5e-68 229.1 0.0 9.1e-68 228.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme SLC12 PF03522.15 EMC77203.1 - 2.4e-162 540.9 0.0 3e-162 540.6 0.0 1.1 1 0 0 1 1 1 1 Solute carrier family 12 AA_permease PF00324.21 EMC77203.1 - 9.1e-152 506.0 38.9 1.1e-151 505.7 38.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EMC77203.1 - 1.1e-19 70.7 45.9 1.7e-19 70.0 45.9 1.2 1 0 0 1 1 1 1 Amino acid permease Laminin_EGF PF00053.24 EMC77204.1 - 3.1e-45 152.1 327.5 0.00036 20.6 14.9 18.8 6 4 12 18 18 18 15 Laminin EGF domain hEGF PF12661.7 EMC77204.1 - 3.8e-23 81.3 271.6 0.0013 19.3 9.9 22.5 23 1 0 23 23 23 16 Human growth factor-like EGF EGF_2 PF07974.13 EMC77204.1 - 4.8e-10 39.6 385.4 0.00037 20.8 18.4 26.2 22 8 4 26 26 26 13 EGF-like domain EGF PF00008.27 EMC77204.1 - 0.0014 18.9 339.0 0.005 17.1 15.6 23.4 25 1 0 25 25 25 12 EGF-like domain Syndecan PF01034.20 EMC77204.1 - 0.014 15.3 1.2 0.027 14.4 1.2 1.4 1 0 0 1 1 1 0 Syndecan domain Baculo_11_kDa PF06143.11 EMC77204.1 - 0.021 14.4 0.8 0.036 13.6 0.8 1.3 1 0 0 1 1 1 0 Baculovirus 11 kDa family RIFIN PF02009.16 EMC77204.1 - 0.17 11.7 0.2 0.28 11.0 0.2 1.2 1 0 0 1 1 1 0 Rifin DUF836 PF05768.14 EMC77205.1 - 3.8e-14 52.9 0.2 5.6e-14 52.3 0.2 1.3 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 EMC77205.1 - 0.002 18.3 0.1 0.003 17.7 0.1 1.4 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_2 PF13098.6 EMC77205.1 - 0.0058 17.1 0.1 0.0064 16.9 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 EMC77205.1 - 0.016 15.3 0.2 0.097 12.9 0.2 2.0 1 1 0 1 1 1 0 Thioredoxin-like RINGv PF12906.7 EMC77206.1 - 1.9e-15 56.7 9.8 4.9e-15 55.4 9.8 1.7 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 EMC77206.1 - 0.0076 16.6 9.2 0.0076 16.6 9.2 2.2 2 0 0 2 2 2 1 Ring finger domain Baculo_IE-1 PF05290.11 EMC77206.1 - 0.018 15.0 1.0 0.029 14.3 1.0 1.3 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-C3HC4 PF00097.25 EMC77206.1 - 0.11 12.4 5.9 0.63 10.0 5.9 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Vpu PF00558.19 EMC77206.1 - 0.19 11.5 0.1 0.33 10.7 0.1 1.3 1 0 0 1 1 1 0 Vpu protein FANCL_C PF11793.8 EMC77206.1 - 7.9 6.7 8.9 4.3 7.6 5.4 2.3 3 0 0 3 3 3 0 FANCL C-terminal domain zf-C3HC4_2 PF13923.6 EMC77207.1 - 8.3e-14 51.2 9.4 1.4e-13 50.4 9.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC77207.1 - 5.6e-11 42.1 8.7 9.5e-11 41.4 8.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC77207.1 - 1.7e-10 41.1 10.2 3e-10 40.2 10.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EMC77207.1 - 8.1e-10 38.4 8.7 1.3e-09 37.7 8.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC77207.1 - 8.2e-07 28.9 6.3 1.5e-06 28.1 6.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC77207.1 - 5.8e-06 26.1 10.7 0.00067 19.5 11.2 2.4 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EMC77207.1 - 1.5e-05 24.9 9.0 2.9e-05 24.0 9.0 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 EMC77207.1 - 7.8e-05 22.9 11.5 0.00028 21.1 11.5 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EMC77207.1 - 0.003 17.7 11.3 0.0054 16.9 11.3 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Baculo_IE-1 PF05290.11 EMC77207.1 - 0.017 15.1 3.9 0.027 14.4 3.9 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_11 PF17123.5 EMC77207.1 - 0.018 14.8 5.2 0.044 13.5 5.2 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-ANAPC11 PF12861.7 EMC77207.1 - 0.027 14.5 5.1 0.056 13.5 5.1 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Rad50_zn_hook PF04423.14 EMC77207.1 - 0.086 12.7 0.6 5.9 6.8 0.1 2.4 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-RING_6 PF14835.6 EMC77207.1 - 0.22 11.4 2.2 0.41 10.5 2.2 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 EMC77207.1 - 0.74 9.7 11.2 7.4 6.5 11.1 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain RNA_GG_bind PF10258.9 EMC77208.1 - 5.9e-33 112.8 2.8 8e-33 112.3 0.2 2.5 3 0 0 3 3 3 1 PHAX RNA-binding domain FoP_duplication PF13865.6 EMC77208.1 - 0.0032 18.0 4.5 0.0032 18.0 4.5 1.9 1 1 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 DUF4446 PF14584.6 EMC77208.1 - 4.5 7.2 6.9 1.2 9.2 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) zf-C2H2 PF00096.26 EMC77209.1 - 1e-16 60.3 21.7 1.6e-05 25.1 2.8 3.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC77209.1 - 1.9e-10 40.7 11.1 1.8e-06 28.1 2.9 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC77209.1 - 1.3e-08 34.9 19.8 0.0084 16.9 2.5 3.4 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2HE PF16278.5 EMC77209.1 - 0.063 13.7 4.6 1.7 9.2 1.1 2.3 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.7 EMC77209.1 - 0.067 13.6 4.4 2.6 8.5 0.4 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type FOXP-CC PF16159.5 EMC77209.1 - 0.082 13.5 6.1 4.8 7.9 1.9 2.6 1 1 2 3 3 3 0 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 EMC77209.1 - 0.15 12.4 4.0 0.29 11.5 4.0 1.4 1 0 0 1 1 1 0 C2H2-type zinc ribbon DUF3850 PF12961.7 EMC77209.1 - 0.18 11.9 0.0 0.3 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3850) zf-C2H2_11 PF16622.5 EMC77209.1 - 1.4 8.8 9.2 16 5.3 1.0 3.3 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 EMC77209.1 - 3.9 7.9 7.0 7.8 6.9 0.4 2.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding XPC-binding PF09280.11 EMC77210.1 - 4.6e-26 90.3 19.4 7.6e-26 89.6 19.4 1.4 1 0 0 1 1 1 1 XPC-binding domain UBA PF00627.31 EMC77210.1 - 2.4e-25 88.0 1.9 7.9e-13 48.0 0.2 2.5 2 0 0 2 2 2 2 UBA/TS-N domain ubiquitin PF00240.23 EMC77210.1 - 1.2e-13 50.6 0.3 2.6e-13 49.5 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin family UBA_3 PF09288.10 EMC77210.1 - 0.00042 20.1 0.0 0.011 15.6 0.0 2.3 2 0 0 2 2 2 1 Fungal ubiquitin-associated domain Rad60-SLD_2 PF13881.6 EMC77210.1 - 0.0024 18.0 0.0 0.0043 17.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EMC77210.1 - 0.039 14.5 0.0 0.081 13.5 0.0 1.6 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain DUF1296 PF06972.11 EMC77210.1 - 0.11 12.6 0.0 3.1 8.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1296) UBA_2 PF08587.11 EMC77210.1 - 0.15 12.2 0.1 0.38 10.9 0.1 1.7 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) STI1 PF17830.1 EMC77210.1 - 2.2 8.3 6.6 14 5.7 6.6 2.2 1 1 0 1 1 1 0 STI1 domain Gln-synt_N_2 PF16952.5 EMC77211.1 - 0.12 12.3 0.0 0.27 11.1 0.0 1.7 1 1 0 1 1 1 0 Glutamine synthetase N-terminal domain Pkinase PF00069.25 EMC77212.1 - 1.3e-51 175.5 0.0 1.5e-51 175.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC77212.1 - 3.7e-49 167.3 0.0 4.6e-49 167.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC77212.1 - 0.0021 16.9 0.0 0.0029 16.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMC77212.1 - 0.073 13.0 0.0 0.26 11.2 0.0 1.9 1 1 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 EMC77212.1 - 0.12 12.0 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 RIO1 family HoxA13_N PF12284.8 EMC77213.1 - 0.034 14.8 1.1 25 5.5 0.0 4.2 1 1 3 4 4 4 0 Hox protein A13 N terminal Adeno_PIX PF03955.14 EMC77213.1 - 0.42 10.8 4.1 52 4.1 0.0 3.8 3 1 1 4 4 4 0 Adenovirus hexon-associated protein (IX) ScsC_N PF18312.1 EMC77213.1 - 2 8.3 13.0 62 3.5 0.7 7.2 9 2 1 10 10 10 0 Copper resistance protein ScsC N-terminal domain dsrm PF00035.26 EMC77217.1 - 2.3e-34 117.9 0.3 7.1e-15 55.5 0.0 3.2 3 0 0 3 3 3 3 Double-stranded RNA binding motif DND1_DSRM PF14709.7 EMC77217.1 - 1.2e-11 44.7 2.3 2.7e-06 27.5 0.1 3.9 3 2 0 3 3 3 2 double strand RNA binding domain from DEAD END PROTEIN 1 Staufen_C PF16482.5 EMC77217.1 - 4.1e-07 30.1 0.1 9.3e-06 25.8 0.0 2.3 2 0 0 2 2 2 1 Staufen C-terminal domain Dicer_dimer PF03368.14 EMC77217.1 - 0.13 12.4 0.7 3.6 7.8 0.0 2.7 2 1 0 2 2 2 0 Dicer dimerisation domain bZIP_1 PF00170.21 EMC77219.1 - 6.1e-13 48.7 7.6 8.8e-13 48.2 7.6 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMC77219.1 - 2.8e-09 36.9 7.9 5.4e-09 36.0 7.9 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EMC77219.1 - 8e-05 23.1 6.9 0.00013 22.4 6.9 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor Cnn_1N PF07989.11 EMC77219.1 - 0.027 14.6 1.7 0.042 14.0 1.7 1.3 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 NDUFB11 PF17250.2 EMC77219.1 - 0.23 12.1 0.4 0.38 11.4 0.4 1.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase 11 kDa subunit GIT_CC PF16559.5 EMC77219.1 - 0.72 9.8 4.9 0.48 10.3 3.0 1.7 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor MR_MLE_C PF13378.6 EMC77220.1 - 0.084 12.4 3.3 0.099 12.2 3.3 1.1 1 0 0 1 1 1 0 Enolase C-terminal domain-like ATP-synt_C PF00137.21 EMC77221.1 - 1.1e-05 25.7 5.1 2.7e-05 24.4 5.1 1.7 1 1 0 1 1 1 1 ATP synthase subunit C Homeodomain PF00046.29 EMC77223.1 - 3.8e-19 68.3 7.6 4.8e-19 68.0 7.6 1.1 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC77223.1 - 2.8e-05 23.9 2.2 5.9e-05 22.9 2.2 1.5 1 0 0 1 1 1 1 Homeobox KN domain DUF1510 PF07423.11 EMC77223.1 - 0.024 14.8 0.1 0.028 14.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1510) Homez PF11569.8 EMC77223.1 - 0.11 12.0 0.1 0.11 12.0 0.1 1.6 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez Homeodomain PF00046.29 EMC77224.1 - 2.5e-18 65.7 7.0 2.5e-18 65.7 7.0 1.7 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 EMC77224.1 - 0.0097 15.8 1.8 0.024 14.5 1.8 1.7 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 EMC77224.1 - 0.097 12.2 0.2 0.097 12.2 0.2 2.4 3 0 0 3 3 3 0 Homeodomain leucine-zipper encoding, Homez DUF3528 PF12045.8 EMC77225.1 - 5e-60 202.2 1.4 8.2e-60 201.5 1.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3528) Homeodomain PF00046.29 EMC77225.1 - 1.8e-19 69.3 8.3 3.7e-19 68.3 8.3 1.5 1 0 0 1 1 1 1 Homeodomain Baculo_p74_N PF08404.10 EMC77225.1 - 0.02 14.0 0.1 0.029 13.5 0.1 1.2 1 0 0 1 1 1 0 Baculoviridae P74 N-terminal Homeobox_KN PF05920.11 EMC77225.1 - 0.033 14.1 0.7 0.08 12.9 0.7 1.7 1 0 0 1 1 1 0 Homeobox KN domain Auxin_canalis PF05703.11 EMC77225.1 - 7.9 6.3 6.4 13 5.6 6.4 1.6 1 1 0 1 1 1 0 Auxin canalisation Homeodomain PF00046.29 EMC77226.1 - 7.1e-21 73.8 6.0 1.7e-20 72.6 6.0 1.7 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC77226.1 - 0.052 13.5 0.4 0.052 13.5 0.4 2.7 2 0 0 2 2 2 0 Homeobox KN domain 4HBT_3 PF13622.6 EMC77226.1 - 1.2 9.3 3.0 2.5 8.3 3.0 1.5 1 0 0 1 1 1 0 Thioesterase-like superfamily Hox9_act PF04617.13 EMC77227.1 - 1.8e-59 201.6 0.8 1.8e-59 201.6 0.8 1.5 2 0 0 2 2 2 1 Hox9 activation region Homeodomain PF00046.29 EMC77227.1 - 8.5e-21 73.6 6.4 1.4e-20 72.9 6.4 1.4 1 0 0 1 1 1 1 Homeodomain HTH_23 PF13384.6 EMC77227.1 - 0.055 13.3 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain CI-B14_5a PF07347.12 EMC77227.1 - 0.068 13.1 0.2 0.19 11.6 0.2 1.7 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) Homeodomain PF00046.29 EMC77228.1 - 1.6e-21 75.9 4.5 1.6e-21 75.9 4.5 1.7 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 EMC77228.1 - 0.0059 16.5 0.1 0.012 15.6 0.1 1.5 1 0 0 1 1 1 1 Homeobox KN domain DUF2380 PF09533.10 EMC77228.1 - 0.042 13.5 0.0 0.061 12.9 0.0 1.3 1 0 0 1 1 1 0 Predicted lipoprotein of unknown function (DUF2380) Homeodomain PF00046.29 EMC77229.1 - 1e-21 76.5 9.9 1.6e-21 75.9 9.9 1.3 1 0 0 1 1 1 1 Homeodomain Terminase_5 PF06056.12 EMC77229.1 - 0.056 13.3 0.2 0.13 12.2 0.2 1.6 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Homeodomain PF00046.29 EMC77230.1 - 1.2e-22 79.5 8.4 2.1e-22 78.7 8.4 1.4 1 0 0 1 1 1 1 Homeodomain DUF2209 PF09974.9 EMC77230.1 - 0.021 15.1 0.1 0.031 14.6 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Chromo_shadow PF01393.19 EMC77232.1 - 1e-28 99.2 0.0 1.2e-28 98.9 0.0 1.1 1 0 0 1 1 1 1 Chromo shadow domain Chromo PF00385.24 EMC77232.1 - 0.12 12.3 0.1 0.23 11.4 0.0 1.6 2 0 0 2 2 2 0 Chromo (CHRromatin Organisation MOdifier) domain RRM_1 PF00076.22 EMC77233.1 - 3.8e-26 90.7 0.3 9e-17 60.7 0.1 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMC77233.1 - 1.3e-07 31.6 0.0 1.5e-06 28.2 0.1 2.3 2 1 0 2 2 2 1 RNA recognition motif OB_RNB PF08206.11 EMC77233.1 - 0.0088 15.7 2.2 0.31 10.7 0.1 2.6 2 1 0 2 2 2 2 Ribonuclease B OB domain RL PF17797.1 EMC77233.1 - 0.039 13.9 0.1 0.07 13.1 0.1 1.4 1 0 0 1 1 1 0 RL domain PHM7_cyt PF14703.6 EMC77233.1 - 0.079 13.2 0.0 1.3 9.2 0.0 2.2 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter EF1G PF00647.19 EMC77234.1 - 8.8e-27 93.3 0.0 1.1e-26 93.0 0.0 1.1 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 EMC77234.1 - 2e-08 34.4 0.0 2.8e-08 33.8 0.0 1.4 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EMC77234.1 - 2e-06 27.7 0.3 5.7e-06 26.3 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EMC77234.1 - 0.00047 20.3 0.0 0.0008 19.6 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain LRR_4 PF12799.7 EMC77235.1 - 2.1e-08 34.3 19.5 0.0054 17.1 0.0 7.4 5 2 5 10 10 10 5 Leucine Rich repeats (2 copies) F-box PF00646.33 EMC77235.1 - 4e-08 32.9 0.4 4e-08 32.9 0.4 2.6 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EMC77235.1 - 6.8e-08 32.3 2.8 2.6e-07 30.4 2.8 2.1 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.6 EMC77235.1 - 4.1e-05 23.3 7.8 3.7 7.8 0.1 6.8 6 0 0 6 6 6 1 Leucine Rich repeat LRR_9 PF14580.6 EMC77235.1 - 0.0002 20.9 0.3 0.5 9.9 0.1 2.5 2 0 0 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 EMC77235.1 - 0.0014 18.4 7.7 0.22 11.3 0.1 4.8 3 2 2 5 5 5 3 Leucine rich repeat F-box_4 PF15966.5 EMC77235.1 - 0.0022 17.9 0.1 0.007 16.2 0.1 1.8 1 0 0 1 1 1 1 F-box LRR_1 PF00560.33 EMC77235.1 - 0.034 14.7 21.2 2.3 9.1 0.2 7.8 8 1 0 8 8 8 0 Leucine Rich Repeat Adeno_E3_CR2 PF02439.15 EMC77235.1 - 0.27 11.0 0.9 0.5 10.2 0.9 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 F-box-like_2 PF13013.6 EMC77235.1 - 7.8 6.5 6.8 4.2 7.4 2.2 2.9 3 1 0 3 3 3 0 F-box-like domain Pou PF00157.17 EMC77236.1 - 4.8e-38 129.0 0.3 9.2e-38 128.1 0.3 1.5 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 EMC77236.1 - 1e-19 70.1 0.3 2.4e-19 68.9 0.3 1.6 1 0 0 1 1 1 1 Homeodomain HTH_31 PF13560.6 EMC77236.1 - 0.00014 22.1 0.0 0.023 15.1 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain Homeobox_KN PF05920.11 EMC77236.1 - 0.003 17.4 0.0 0.007 16.3 0.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain DUF521 PF04412.13 EMC77236.1 - 0.12 11.1 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF521) MMS22L_N PF14910.6 EMC77237.1 - 0 1220.7 21.5 0 1220.0 21.5 1.3 1 0 0 1 1 1 1 S-phase genomic integrity recombination mediator, N-terminal MMS22L_C PF14911.6 EMC77237.1 - 5e-146 486.6 4.6 5e-146 486.6 4.6 1.8 2 0 0 2 2 2 1 S-phase genomic integrity recombination mediator, C-terminal UPF0240 PF06784.11 EMC77238.1 - 2.3e-37 128.7 0.2 2.8e-37 128.4 0.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0240) 7tm_1 PF00001.21 EMC77239.1 - 8.7e-50 169.5 23.9 1.2e-49 169.0 23.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC77239.1 - 4.7e-07 29.4 25.4 7.6e-07 28.8 25.4 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC77239.1 - 0.0014 18.4 9.4 0.0014 18.4 9.4 2.9 3 0 0 3 3 3 1 Olfactory receptor DUF5527 PF17665.1 EMC77239.1 - 0.063 12.8 0.7 0.17 11.4 0.7 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5527) LIM PF00412.22 EMC77240.1 - 6.8e-49 163.9 63.3 5.1e-13 49.0 6.7 5.1 5 0 0 5 5 5 5 LIM domain TNFR_c6 PF00020.18 EMC77240.1 - 0.31 11.5 0.3 0.31 11.5 0.3 9.9 8 3 1 10 10 10 0 TNFR/NGFR cysteine-rich region E3_UFM1_ligase PF09743.9 EMC77241.1 - 1.4e-112 375.8 0.1 1.4e-112 375.8 0.1 2.1 3 0 0 3 3 3 1 E3 UFM1-protein ligase 1 RhoGAP PF00620.27 EMC77241.1 - 0.071 12.9 2.9 2.3 8.0 0.1 2.7 1 1 0 2 2 2 0 RhoGAP domain Tn7_Tnp_TnsA_C PF08721.11 EMC77241.1 - 1.1 9.9 0.0 1.1 9.9 0.0 4.0 6 0 0 6 6 6 0 TnsA endonuclease C terminal Glyco_transf_10 PF00852.19 EMC77242.1 - 2.7e-67 225.9 3.5 3.6e-67 225.5 3.5 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 EMC77242.1 - 4e-41 139.9 0.1 1.2e-40 138.4 0.1 1.8 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Glyco_hydro_99 PF16317.5 EMC77243.1 - 3.2e-170 565.8 10.7 3.8e-170 565.5 10.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 99 hNIFK_binding PF12196.8 EMC77244.1 - 0.085 12.4 0.4 0.085 12.4 0.4 7.1 7 0 0 7 7 7 0 FHA Ki67 binding domain of hNIFK 4HBT PF03061.22 EMC77245.1 - 1.2e-13 51.2 0.1 1.5e-13 50.9 0.1 1.1 1 0 0 1 1 1 1 Thioesterase superfamily DUF92 PF01940.16 EMC77246.1 - 0.039 13.4 0.0 0.039 13.4 0.0 1.0 1 0 0 1 1 1 0 Integral membrane protein DUF92 DUF2065 PF09838.9 EMC77246.1 - 0.072 13.1 0.0 0.096 12.7 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2065) DED PF01335.21 EMC77247.1 - 1.4e-07 31.7 1.1 0.0026 18.0 0.0 2.9 2 1 1 3 3 3 2 Death effector domain ComZ PF10815.8 EMC77247.1 - 0.17 11.9 0.0 1.4 9.0 0.0 2.1 2 0 0 2 2 2 0 ComZ MHC_I_3 PF16497.5 EMC77248.1 - 8.8e-30 103.7 0.1 1.1e-29 103.3 0.1 1.1 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.15 EMC77248.1 - 1.3e-17 64.0 0.0 2.4e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.18 EMC77248.1 - 5.1e-07 29.4 0.0 7.1e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Ig_2 PF13895.6 EMC77248.1 - 6.7e-05 23.1 0.0 0.00014 22.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC77248.1 - 0.00027 21.5 0.0 0.00047 20.7 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 EMC77248.1 - 0.0046 17.0 0.0 0.0075 16.3 0.0 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain I-set PF07679.16 EMC77248.1 - 0.011 15.7 0.0 0.022 14.8 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain DSPc PF00782.20 EMC77250.1 - 4.2e-12 46.0 0.0 1.1e-11 44.7 0.0 1.8 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC77250.1 - 3.2e-08 33.4 0.0 6e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 EMC77250.1 - 0.00073 19.2 0.0 0.0015 18.2 0.0 1.5 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase3 PF13350.6 EMC77250.1 - 0.0094 15.9 0.0 0.023 14.7 0.0 1.6 1 0 0 1 1 1 1 Tyrosine phosphatase family 23S_rRNA_IVP PF05635.11 EMC77250.1 - 0.034 14.5 0.0 0.19 12.0 0.0 2.4 2 0 0 2 2 2 0 23S rRNA-intervening sequence protein KRAB PF01352.27 EMC77251.1 - 2.6e-23 81.4 0.2 2.9e-23 81.3 0.2 1.0 1 0 0 1 1 1 1 KRAB box Erythro-docking PF09277.11 EMC77252.1 - 0.093 12.7 0.1 0.18 11.7 0.1 1.4 1 0 0 1 1 1 0 Erythronolide synthase, docking WW PF00397.26 EMC77253.1 - 1.8e-08 34.3 9.8 9.5e-06 25.6 6.4 3.1 3 1 0 3 3 3 2 WW domain ANAPC1 PF12859.7 EMC77253.1 - 0.033 14.7 0.1 0.15 12.6 0.0 2.1 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 1 DUF5111 PF17138.4 EMC77253.1 - 0.18 11.7 1.0 0.78 9.6 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5111) DUF515 PF04415.12 EMC77253.1 - 2.6 6.3 4.6 3.8 5.8 4.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) AF-4 PF05110.13 EMC77254.1 - 0.056 11.5 68.6 0.068 11.3 68.6 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF4505 PF14956.6 EMC77256.1 - 3.5e-55 186.5 0.0 3.9e-55 186.3 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4505) LRR_6 PF13516.6 EMC77257.1 - 2.7e-08 33.2 5.1 0.086 12.9 0.1 6.0 6 0 0 6 6 6 3 Leucine Rich repeat LRR_4 PF12799.7 EMC77257.1 - 0.00078 19.8 7.8 1.8 9.1 0.1 4.6 5 0 0 5 5 5 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMC77257.1 - 1.3 8.8 7.7 9.5 6.1 0.2 4.4 3 1 0 3 3 3 0 Leucine rich repeat F5_F8_type_C PF00754.25 EMC77258.1 - 2.4e-12 47.1 4.2 0.0045 17.1 0.1 4.5 4 0 0 4 4 4 3 F5/8 type C domain Aminotran_1_2 PF00155.21 EMC77259.1 - 2.2e-32 112.6 0.0 2.8e-32 112.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Atg8 PF02991.16 EMC77262.1 - 3e-45 152.7 0.4 3.4e-45 152.5 0.4 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EMC77262.1 - 2.6e-06 27.8 0.0 3.2e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Cytochrom_B559a PF00284.20 EMC77262.1 - 0.13 12.0 0.1 0.39 10.5 0.1 1.8 1 1 1 2 2 2 0 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit Robl_LC7 PF03259.17 EMC77263.1 - 3.6e-26 90.8 0.0 3.9e-26 90.6 0.0 1.0 1 0 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.5 EMC77263.1 - 3.7e-05 23.6 0.0 4.3e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 UPF0176_N PF17773.1 EMC77263.1 - 0.061 13.7 0.0 0.069 13.5 0.0 1.2 1 0 0 1 1 1 0 UPF0176 acylphosphatase like domain HECT PF00632.25 EMC77264.1 - 1.7e-98 329.9 0.2 2.4e-98 329.4 0.2 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 EMC77264.1 - 3e-45 152.0 19.5 7.3e-14 51.6 0.9 4.7 4 0 0 4 4 4 4 WW domain C2 PF00168.30 EMC77264.1 - 1.3e-15 57.6 0.9 3.2e-15 56.3 0.9 1.7 1 0 0 1 1 1 1 C2 domain SOG2 PF10428.9 EMC77264.1 - 0.88 8.7 12.3 1.5 7.9 12.3 1.4 1 0 0 1 1 1 0 RAM signalling pathway protein AdoHcyase PF05221.17 EMC77265.1 - 4.4e-135 449.6 0.0 7.5e-72 242.0 0.2 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 EMC77265.1 - 2e-85 284.8 3.2 2.9e-85 284.3 3.2 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EMC77265.1 - 2e-09 37.1 0.1 3.7e-09 36.2 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EMC77265.1 - 7.6e-06 25.6 0.1 1.3e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 EMC77265.1 - 0.0015 18.8 0.1 0.0032 17.7 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain 3HCDH_N PF02737.18 EMC77265.1 - 0.0046 16.9 1.1 0.019 14.9 1.1 2.0 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 EMC77265.1 - 0.0083 15.4 0.3 0.36 10.0 0.2 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ELFV_dehydrog PF00208.21 EMC77265.1 - 0.029 14.1 0.2 0.055 13.2 0.2 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Shikimate_DH PF01488.20 EMC77265.1 - 0.13 12.3 0.1 0.22 11.6 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Agouti PF05039.12 EMC77266.1 - 6e-15 55.7 17.3 7.1e-15 55.5 16.6 1.5 1 1 0 1 1 1 1 Agouti protein Toxin_9 PF02819.15 EMC77266.1 - 6.4 7.2 21.1 2.5 8.4 18.6 1.7 2 0 0 2 2 2 0 Spider toxin SRCR PF00530.18 EMC77267.1 - 4.4e-32 110.6 5.3 2.5e-22 79.3 0.2 2.1 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 EMC77267.1 - 0.00035 21.0 1.9 0.64 10.6 0.1 2.2 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Ecm29 PF13001.7 EMC77268.1 - 2.5e-81 273.9 0.0 2.5e-81 273.9 0.0 3.8 5 0 0 5 5 5 1 Proteasome stabiliser HEAT_2 PF13646.6 EMC77268.1 - 3.2e-14 53.1 1.8 0.68 10.4 0.0 8.5 6 1 1 7 7 7 4 HEAT repeats HEAT PF02985.22 EMC77268.1 - 3.3e-11 42.4 16.8 2.1 8.8 0.0 12.3 13 0 0 13 13 12 2 HEAT repeat Vac14_Fab1_bd PF12755.7 EMC77268.1 - 4.3e-11 43.3 0.0 0.001 19.6 0.0 7.6 9 1 1 10 10 7 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EMC77268.1 - 2.1e-09 37.7 11.7 2.9 8.5 0.1 10.8 12 1 1 13 13 11 2 HEAT-like repeat IFRD PF05004.13 EMC77268.1 - 2.2e-09 36.9 18.7 0.019 14.1 0.0 6.5 6 0 0 6 6 6 5 Interferon-related developmental regulator (IFRD) Adaptin_N PF01602.20 EMC77268.1 - 0.00031 19.4 11.5 0.012 14.2 0.7 5.7 4 2 0 6 6 6 1 Adaptin N terminal region Cnd1 PF12717.7 EMC77268.1 - 0.0066 16.5 12.2 5 7.1 0.1 6.6 7 1 1 8 8 8 1 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 EMC77268.1 - 0.024 14.2 14.6 0.06 12.9 0.1 5.4 6 1 1 7 7 7 0 CLASP N terminal Catalase-rel PF06628.12 EMC77268.1 - 0.035 14.3 0.1 3 8.1 0.0 3.3 3 0 0 3 3 3 0 Catalase-related immune-responsive MA3 PF02847.17 EMC77268.1 - 0.06 13.3 0.1 11 6.1 0.0 3.9 3 0 0 3 3 3 0 MA3 domain PUL PF08324.11 EMC77268.1 - 0.12 11.6 2.3 1.9 7.7 0.0 3.6 4 0 0 4 4 4 0 PUL domain DUF2325 PF10087.9 EMC77268.1 - 0.16 12.1 0.0 3.3 7.9 0.0 2.9 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2325) RTP1_C1 PF10363.9 EMC77268.1 - 0.75 10.0 8.1 10 6.4 0.1 5.5 7 0 0 7 7 7 0 Required for nuclear transport of RNA pol II C-terminus 1 SMC_N PF02463.19 EMC77269.1 - 1e-26 93.7 8.1 2.6e-26 92.5 8.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Spc7 PF08317.11 EMC77269.1 - 0.00036 19.5 37.2 0.00036 19.5 37.2 3.1 2 1 1 3 3 3 1 Spc7 kinetochore protein AAA_21 PF13304.6 EMC77269.1 - 0.0012 18.7 1.6 0.0026 17.6 1.6 1.9 1 1 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system FliJ PF02050.16 EMC77269.1 - 0.0023 18.1 20.8 0.0023 18.1 20.8 3.7 3 2 0 3 3 3 1 Flagellar FliJ protein BRE1 PF08647.11 EMC77269.1 - 0.024 14.7 10.2 0.024 14.7 10.2 5.3 2 2 3 5 5 5 0 BRE1 E3 ubiquitin ligase ABC_tran PF00005.27 EMC77269.1 - 0.57 10.7 18.7 2.7e+02 2.0 18.7 3.5 1 1 0 1 1 1 0 ABC transporter IFT57 PF10498.9 EMC77269.1 - 3.9 6.3 49.2 0.22 10.4 12.1 3.1 2 1 1 3 3 3 0 Intra-flagellar transport protein 57 SNARE PF05739.19 EMC77269.1 - 9.8 6.3 6.9 21 5.2 0.4 2.7 2 0 0 2 2 2 0 SNARE domain ADH_N_2 PF16884.5 EMC77270.1 - 2.2e-35 120.8 0.0 4.8e-35 119.7 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 EMC77270.1 - 1.3e-24 86.6 0.2 2e-24 86.0 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMC77270.1 - 1.6e-11 45.4 0.0 3e-11 44.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Thioredoxin PF00085.20 EMC77271.1 - 1.3e-29 102.2 0.8 1.4e-29 102.1 0.8 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EMC77271.1 - 1e-05 25.8 0.2 1.5e-05 25.2 0.2 1.5 1 1 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 EMC77271.1 - 0.00017 21.5 0.2 0.00021 21.2 0.2 1.2 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_2 PF13098.6 EMC77271.1 - 0.00051 20.5 0.2 0.0034 17.8 0.2 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 EMC77271.1 - 0.0018 17.7 0.2 0.002 17.5 0.2 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Glutaredoxin PF00462.24 EMC77271.1 - 0.0027 17.9 0.6 0.0043 17.2 0.6 1.4 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_7 PF13899.6 EMC77271.1 - 0.004 17.3 0.2 0.0067 16.6 0.2 1.5 1 1 0 1 1 1 1 Thioredoxin-like DIM1 PF02966.16 EMC77271.1 - 0.023 14.5 0.1 0.026 14.3 0.1 1.0 1 0 0 1 1 1 0 Mitosis protein DIM1 Thioredoxin_9 PF14595.6 EMC77271.1 - 0.035 13.9 0.2 0.054 13.3 0.1 1.4 1 1 0 1 1 1 0 Thioredoxin Sushi PF00084.20 EMC77272.1 - 0 1096.8 277.4 2.7e-13 50.3 3.5 37.5 36 2 2 38 38 36 34 Sushi repeat (SCR repeat) Ephrin_rec_like PF07699.13 EMC77272.1 - 9e-55 182.2 60.1 9.3e-15 54.1 6.0 8.1 6 0 0 6 6 6 4 Putative ephrin-receptor like EGF PF00008.27 EMC77272.1 - 1e-52 176.0 169.1 5.1e-09 36.3 3.9 17.1 13 0 0 13 13 12 10 EGF-like domain HYR PF02494.16 EMC77272.1 - 1.3e-35 121.5 1.5 1.5e-17 63.7 0.0 3.0 2 0 0 2 2 2 2 HYR domain Pentaxin PF00354.17 EMC77272.1 - 7.7e-27 94.2 0.0 1.4e-26 93.4 0.0 1.3 1 0 0 1 1 1 1 Pentaxin family hEGF PF12661.7 EMC77272.1 - 2.1e-25 88.4 167.6 2.6e-06 27.8 1.4 18.0 17 0 0 17 17 16 8 Human growth factor-like EGF Laminin_G_3 PF13385.6 EMC77272.1 - 8.1e-20 71.5 0.6 1.5e-19 70.6 0.6 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily VWA PF00092.28 EMC77272.1 - 8.9e-16 58.6 0.0 1.6e-15 57.8 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain EGF_2 PF07974.13 EMC77272.1 - 2.6e-14 53.3 186.1 8.1e-05 22.9 5.2 16.1 13 0 0 13 13 12 7 EGF-like domain EGF_CA PF07645.15 EMC77272.1 - 1.2e-09 38.2 35.6 2.2e-07 31.0 8.9 23.2 23 2 2 25 25 20 7 Calcium-binding EGF domain EGF_3 PF12947.7 EMC77272.1 - 6.1e-07 29.5 9.9 6.1e-07 29.5 9.9 18.6 18 2 1 19 19 17 7 EGF domain EGF_MSP1_1 PF12946.7 EMC77272.1 - 0.00077 19.5 5.2 0.00077 19.5 5.2 14.5 15 0 0 15 15 13 2 MSP1 EGF domain 1 Laminin_G_2 PF02210.24 EMC77272.1 - 0.0034 18.0 0.0 0.0066 17.0 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain Pkinase_Tyr PF07714.17 EMC77273.1 - 1.7e-94 315.9 0.0 2.3e-94 315.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase I-set PF07679.16 EMC77273.1 - 1e-45 153.7 0.0 2e-19 69.4 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC77273.1 - 4.1e-41 139.4 0.5 4.4e-16 59.2 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Pkinase PF00069.25 EMC77273.1 - 5.4e-40 137.4 0.0 1.1e-39 136.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Ig_2 PF13895.6 EMC77273.1 - 4.7e-28 97.3 0.1 8.3e-11 42.1 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Kringle PF00051.18 EMC77273.1 - 4.9e-24 84.4 8.0 1.3e-23 83.1 8.0 1.8 1 0 0 1 1 1 1 Kringle domain ig PF00047.25 EMC77273.1 - 7.3e-18 64.5 0.0 4.6e-09 36.3 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Fz PF01392.22 EMC77273.1 - 1e-15 58.3 4.4 2.7e-15 57.0 4.4 1.8 1 0 0 1 1 1 1 Fz domain C2-set_2 PF08205.12 EMC77273.1 - 8.5e-11 41.8 0.1 0.0041 17.2 0.0 3.7 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain V-set PF07686.17 EMC77273.1 - 2.6e-08 34.0 4.0 0.025 14.8 0.0 5.1 4 2 1 5 5 5 2 Immunoglobulin V-set domain Ig_6 PF18452.1 EMC77273.1 - 1.8e-06 27.4 0.0 0.07 12.7 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain Adeno_E3_CR1 PF02440.15 EMC77273.1 - 0.0045 16.7 0.0 1.6 8.6 0.0 2.9 2 0 0 2 2 2 1 Adenovirus E3 region protein CR1 Ig_4 PF16680.5 EMC77273.1 - 0.011 15.9 0.0 2 8.7 0.0 3.4 3 0 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain Adeno_E3_CR2 PF02439.15 EMC77273.1 - 0.012 15.3 0.5 0.025 14.3 0.5 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Haspin_kinase PF12330.8 EMC77273.1 - 0.022 13.7 0.0 0.035 13.1 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain C1-set PF07654.15 EMC77273.1 - 0.027 14.8 0.0 1.8 9.0 0.0 2.6 2 0 0 2 2 2 0 Immunoglobulin C1-set domain Izumo-Ig PF16706.5 EMC77273.1 - 0.042 13.9 0.1 0.67 10.1 0.0 2.4 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain EphA2_TM PF14575.6 EMC77273.1 - 0.15 12.9 0.0 0.31 11.9 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain CD34_antigen PF06365.12 EMC77273.1 - 0.15 11.6 0.2 0.27 10.8 0.2 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family 7tm_1 PF00001.21 EMC77274.1 - 7.1e-37 127.2 22.1 9.6e-37 126.7 22.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC77274.1 - 0.00028 20.7 16.1 0.0054 16.5 16.1 2.1 1 1 0 1 1 1 1 Olfactory receptor Guanylate_cyc PF00211.20 EMC77275.1 - 1.8e-64 216.8 0.3 1.3e-63 213.9 0.1 2.1 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Pkinase_Tyr PF07714.17 EMC77275.1 - 2.6e-43 148.2 0.0 4.1e-43 147.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC77275.1 - 1.5e-33 116.3 0.0 2.6e-33 115.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain HNOBA PF07701.14 EMC77275.1 - 1.6e-06 27.7 1.4 2.5e-06 27.1 1.4 1.3 1 0 0 1 1 1 1 Heme NO binding associated TMEM215 PF15746.5 EMC77276.1 - 2.3e-122 406.6 1.4 2.6e-122 406.5 1.4 1.0 1 0 0 1 1 1 1 TMEM215 family zf-C3HC4_2 PF13923.6 EMC77277.1 - 1.3e-10 40.9 7.9 1.3e-10 40.9 7.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMC77277.1 - 1.3e-09 37.8 5.5 1.3e-09 37.8 5.5 2.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC77277.1 - 3.8e-09 36.3 7.1 3.8e-09 36.3 7.1 3.0 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC77277.1 - 1e-08 35.4 9.0 1e-08 35.4 9.0 2.8 3 0 0 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.6 EMC77277.1 - 3e-07 30.3 1.8 3e-07 30.3 1.8 3.4 3 1 0 3 3 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMC77277.1 - 2.1e-05 24.4 8.2 2.1e-05 24.4 8.2 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EMC77277.1 - 3.3e-05 24.0 7.7 3.3e-05 24.0 7.7 2.6 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EMC77277.1 - 5.5e-05 23.4 5.5 5.5e-05 23.4 5.5 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EMC77277.1 - 0.0012 18.6 9.9 0.02 14.7 9.5 2.9 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EMC77277.1 - 0.0042 17.1 3.1 0.013 15.5 3.1 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-P11 PF03854.14 EMC77277.1 - 0.72 9.6 6.0 2.3 8.0 6.0 1.9 1 0 0 1 1 1 0 P-11 zinc finger zf-RING_4 PF14570.6 EMC77277.1 - 2.8 7.8 14.7 0.5 10.2 9.4 2.6 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 EMC77278.1 - 7.1e-67 221.2 0.1 2.2e-21 75.4 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMC77278.1 - 6.9e-13 48.3 0.0 0.00017 21.2 0.0 3.2 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 EMC77278.1 - 5.7e-05 23.3 0.0 0.74 10.1 0.0 2.8 3 0 0 3 3 3 2 BRCA1-associated protein 2 RRM_occluded PF16842.5 EMC77278.1 - 0.00024 20.9 0.1 0.39 10.6 0.0 3.3 3 1 0 3 3 3 1 Occluded RNA-recognition motif RRM_7 PF16367.5 EMC77278.1 - 0.0011 19.0 0.0 1.5 9.0 0.0 3.2 3 0 0 3 3 3 1 RNA recognition motif RRM_3 PF08777.11 EMC77278.1 - 0.0015 18.5 0.0 0.86 9.7 0.0 2.5 2 0 0 2 2 2 2 RNA binding motif SAM_LFY PF01698.16 EMC77278.1 - 0.069 13.1 0.0 23 5.0 0.0 3.3 3 0 0 3 3 3 0 Floricaula / Leafy protein SAM domain Pex14_N PF04695.13 EMC77278.1 - 0.086 13.5 0.2 0.39 11.3 0.1 2.0 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Nup35_RRM_2 PF14605.6 EMC77278.1 - 0.1 12.6 0.0 17 5.5 0.0 2.7 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_2 PF04059.12 EMC77278.1 - 0.13 12.5 0.1 0.76 10.0 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif 2 Yae1_N PF09811.9 EMC77279.1 - 9.9e-11 41.2 48.9 1.8e+04 -14.9 48.9 5.7 1 1 0 1 1 1 0 Essential protein Yae1, N terminal CAAP1 PF15335.6 EMC77280.1 - 7.7e-29 100.0 9.5 1.6e-28 99.1 9.5 1.5 1 0 0 1 1 1 1 Caspase activity and apoptosis inhibitor 1 Sld5 PF05916.11 EMC77280.1 - 0.0068 16.9 1.6 0.82 10.2 0.0 2.3 2 1 0 2 2 2 2 GINS complex protein Rb_C PF08934.10 EMC77280.1 - 0.19 11.5 1.5 0.29 10.9 1.5 1.3 1 0 0 1 1 1 0 Rb C-terminal domain VRR_NUC PF08774.11 EMC77281.1 - 0.0021 18.1 0.7 0.015 15.4 0.7 2.5 1 0 0 1 1 1 1 VRR-NUC domain OmpH PF03938.14 EMC77281.1 - 0.0055 17.0 10.0 0.0055 17.0 10.0 6.0 1 1 4 5 5 5 2 Outer membrane protein (OmpH-like) Spc7 PF08317.11 EMC77281.1 - 0.12 11.2 89.8 0.063 12.2 25.1 4.9 1 1 2 4 4 4 0 Spc7 kinetochore protein FUSC PF04632.12 EMC77281.1 - 2.6 6.5 15.1 1.4 7.4 4.3 2.4 1 1 0 2 2 2 0 Fusaric acid resistance protein family FPP PF05911.11 EMC77281.1 - 5.8 5.0 79.7 0.071 11.3 42.4 2.2 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil T2SSG PF08334.11 EMC77281.1 - 6.9 6.8 9.6 1.1 9.4 0.7 3.7 3 1 1 4 4 4 0 Type II secretion system (T2SS), protein G LRR19-TM PF15176.6 EMC77282.1 - 4.3e-30 103.7 0.0 7.5e-30 102.9 0.0 1.4 1 0 0 1 1 1 1 Leucine-rich repeat family 19 TM domain LRR_8 PF13855.6 EMC77282.1 - 2.1e-19 69.0 26.2 1.4e-14 53.6 7.7 3.2 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 EMC77282.1 - 2.6e-09 37.2 29.1 7.5e-05 23.0 2.0 4.0 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC77282.1 - 2.7e-05 24.1 9.1 2.7e-05 24.1 9.1 2.5 2 1 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EMC77282.1 - 0.00082 19.6 17.7 1.3 9.9 1.3 6.1 6 1 0 6 6 6 2 Leucine Rich Repeat LRR_9 PF14580.6 EMC77282.1 - 0.025 14.1 10.6 0.25 10.8 5.2 2.3 1 1 1 2 2 2 0 Leucine-rich repeat EloA-BP1 PF15870.5 EMC77283.1 - 1.5e-27 96.9 0.6 1e-24 87.6 0.6 3.0 1 1 0 1 1 1 1 ElonginA binding-protein 1 Mob1_phocein PF03637.17 EMC77284.1 - 2.4e-81 271.8 0.2 2.8e-81 271.5 0.2 1.0 1 0 0 1 1 1 1 Mob1/phocein family Interferon PF00143.19 EMC77285.1 - 2.3e-44 151.4 7.2 2.7e-44 151.2 7.2 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain DUF1397 PF07165.11 EMC77285.1 - 0.043 13.2 0.8 0.12 11.8 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1397) C9orf72-like PF15019.6 EMC77286.1 - 2.2e-97 325.4 0.0 3.2e-97 324.9 0.0 1.2 1 0 0 1 1 1 1 C9orf72-like protein family RVT_1 PF00078.27 EMC77287.1 - 0.001 18.6 0.0 0.0016 18.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Tetraspanin PF00335.20 EMC77288.1 - 2.6e-24 86.2 5.7 2.9e-24 86.1 5.7 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF202 PF02656.15 EMC77288.1 - 1.8 9.1 4.8 13 6.3 4.8 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF202) SOBP PF15279.6 EMC77294.1 - 0.29 11.7 15.5 0.65 10.5 15.5 1.6 1 0 0 1 1 1 0 Sine oculis-binding protein MDM1 PF15501.6 EMC77294.1 - 0.73 8.9 50.5 1.4 8.0 50.5 1.4 1 0 0 1 1 1 0 Nuclear protein MDM1 Dapper PF15268.6 EMC77294.1 - 5.4 5.7 35.7 8.5 5.1 35.7 1.2 1 0 0 1 1 1 0 Dapper CTF_NFI PF00859.18 EMC77295.1 - 7.7e-145 482.3 24.9 9.7e-145 482.0 24.9 1.1 1 0 0 1 1 1 1 CTF/NF-I family transcription modulation region NfI_DNAbd_pre-N PF10524.9 EMC77295.1 - 1.2e-25 89.0 4.3 2.1e-25 88.3 4.3 1.4 1 0 0 1 1 1 1 Nuclear factor I protein pre-N-terminus MH1 PF03165.16 EMC77295.1 - 2.8e-12 46.7 0.5 5.2e-12 45.9 0.5 1.4 1 0 0 1 1 1 1 MH1 domain MAP17 PF15807.5 EMC77296.1 - 4.2e-22 78.7 0.2 4.9e-22 78.5 0.2 1.0 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 UL41A PF17591.2 EMC77296.1 - 0.0046 17.0 0.0 0.0053 16.8 0.0 1.2 1 0 0 1 1 1 1 Herpesvirus UL41A LPG_synthase_TM PF03706.13 EMC77296.1 - 0.0081 15.7 3.5 0.0084 15.7 3.5 1.0 1 0 0 1 1 1 1 Lysylphosphatidylglycerol synthase TM region DUF2208 PF09973.9 EMC77296.1 - 0.015 14.9 0.0 0.018 14.7 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) DUF5531 PF17671.1 EMC77296.1 - 0.044 13.7 0.1 0.058 13.3 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5531) Vpu PF00558.19 EMC77296.1 - 0.049 13.4 0.0 0.087 12.6 0.0 1.4 1 0 0 1 1 1 0 Vpu protein TMEM132D_C PF15706.5 EMC77296.1 - 0.06 13.1 0.1 0.098 12.4 0.1 1.5 1 1 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF4079 PF13301.6 EMC77296.1 - 0.069 13.3 0.3 0.14 12.3 0.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) DUF4094 PF13334.6 EMC77296.1 - 0.07 13.5 0.0 0.098 13.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) DUF4446 PF14584.6 EMC77296.1 - 0.092 12.7 0.0 0.12 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Cadherin_C_2 PF16492.5 EMC77296.1 - 0.12 13.2 0.0 0.18 12.5 0.0 1.4 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal EphA2_TM PF14575.6 EMC77296.1 - 0.37 11.7 0.0 0.37 11.7 0.0 1.4 2 0 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain HEAT_2 PF13646.6 EMC77297.1 - 6.4e-29 100.2 1.4 3.3e-13 49.8 0.0 3.4 2 2 1 3 3 3 3 HEAT repeats HEAT_PBS PF03130.16 EMC77297.1 - 9.6e-25 84.7 7.5 0.0034 17.9 0.0 6.4 6 0 0 6 6 6 5 PBS lyase HEAT-like repeat HEAT PF02985.22 EMC77297.1 - 9.4e-08 31.7 2.3 0.062 13.6 0.1 5.4 5 0 0 5 5 5 2 HEAT repeat Arm PF00514.23 EMC77297.1 - 3.2e-05 23.8 0.2 0.15 12.1 0.0 3.3 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EMC77297.1 - 0.00065 20.1 2.8 1.3 9.6 0.1 4.1 3 1 0 3 3 3 2 HEAT-like repeat TAF6_C PF07571.13 EMC77297.1 - 0.065 13.6 0.1 25 5.3 0.0 2.9 3 1 0 3 3 3 0 TAF6 C-terminal HEAT repeat domain MarR_2 PF12802.7 EMC77297.1 - 0.075 12.9 1.2 2.4 8.1 0.1 3.0 3 0 0 3 3 3 0 MarR family WD40 PF00400.32 EMC77298.1 - 2e-27 94.9 7.3 5e-06 27.2 0.0 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC77298.1 - 9.8e-16 57.8 4.2 7e-06 26.3 0.2 4.3 2 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC77298.1 - 3.9e-06 26.9 0.1 0.12 12.3 0.0 3.2 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EMC77298.1 - 0.012 14.3 0.7 0.026 13.2 0.1 1.8 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EMC77298.1 - 0.014 14.4 0.0 0.11 11.5 0.0 2.4 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF4531 PF15041.6 EMC77299.1 - 3.8e-37 128.1 6.6 4.5e-37 127.9 6.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4531) HMG_box PF00505.19 EMC77300.1 - 2.1e-20 72.9 1.1 7.9e-20 71.1 1.1 2.0 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC77300.1 - 1e-11 45.3 0.4 1e-11 45.3 0.4 2.1 2 0 0 2 2 2 1 HMG-box domain LMBR1 PF04791.16 EMC77300.1 - 0.024 13.6 3.1 0.029 13.3 3.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF812 PF05667.11 EMC77300.1 - 0.097 11.5 14.3 0.15 10.9 14.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF724 PF05266.14 EMC77300.1 - 0.21 11.4 12.3 0.12 12.2 3.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) APG6_N PF17675.1 EMC77300.1 - 0.67 10.5 25.7 7 7.2 25.6 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region AAA_23 PF13476.6 EMC77300.1 - 0.75 10.3 17.9 1.5 9.3 3.3 2.1 2 0 0 2 2 2 0 AAA domain HIP1_clath_bdg PF16515.5 EMC77300.1 - 0.75 10.4 23.1 0.6 10.8 3.1 2.4 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4763 PF15960.5 EMC77300.1 - 3 7.1 20.3 6.1 6.1 20.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) PI3K_P85_iSH2 PF16454.5 EMC77300.1 - 3.1 7.4 25.4 22 4.6 25.4 2.1 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain TMPIT PF07851.13 EMC77300.1 - 3.8 6.7 9.5 1.1 8.4 1.2 2.1 2 0 0 2 2 2 0 TMPIT-like protein PDZ PF00595.24 EMC77301.1 - 4.5e-08 33.3 0.0 6.6e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC77301.1 - 0.083 12.7 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 PDZ domain 7tm_1 PF00001.21 EMC77302.1 - 3.1e-28 98.8 13.1 3.6e-28 98.6 13.1 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC77302.1 - 5.5e-10 39.3 10.2 9.7e-10 38.5 10.2 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 EMC77302.1 - 0.00037 19.9 3.1 0.0005 19.5 3.1 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv THEG4 PF15834.5 EMC77302.1 - 0.067 13.2 1.0 1.7 8.6 0.1 2.6 2 0 0 2 2 2 0 Testis highly expressed protein 4 PIP5K PF01504.18 EMC77303.1 - 1e-93 313.5 0.0 1.7e-93 312.8 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Hemopexin PF00045.19 EMC77303.1 - 0.035 14.0 0.6 0.087 12.8 0.6 1.7 1 0 0 1 1 1 0 Hemopexin Toxin_33 PF08121.11 EMC77303.1 - 0.26 11.1 0.8 0.52 10.2 0.8 1.5 1 0 0 1 1 1 0 Waglerin family Pentapeptide_4 PF13599.6 EMC77304.1 - 1.2e-06 28.5 0.0 0.00059 20.0 0.0 2.2 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Innate_immun PF12782.7 EMC77304.1 - 0.038 13.5 0.0 0.79 9.2 0.0 2.0 1 1 1 2 2 2 0 Invertebrate innate immunity transcript family VirionAssem_T7 PF11653.8 EMC77304.1 - 0.96 10.0 3.7 25 5.5 0.2 3.1 1 1 3 4 4 4 0 Bacteriophage T7 virion assembly protein PDZ PF00595.24 EMC77305.1 - 1.2e-43 147.4 3.5 1.5e-13 50.9 0.0 3.4 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 EMC77305.1 - 2.8e-28 97.5 1.1 3.9e-10 39.4 0.0 3.8 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 EMC77305.1 - 1.8e-19 69.9 1.7 4.4e-07 30.1 0.0 3.5 3 0 0 3 3 3 3 PDZ domain SH3_2 PF07653.17 EMC77305.1 - 9.6e-11 41.2 0.0 2.6e-10 39.8 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Guanylate_kin PF00625.21 EMC77305.1 - 1.3e-09 38.0 0.0 7.5e-09 35.5 0.0 2.0 1 1 1 2 2 2 1 Guanylate kinase Tricorn_PDZ PF14685.6 EMC77305.1 - 0.00021 21.2 1.1 1.4 8.9 0.0 3.4 3 0 0 3 3 3 2 Tricorn protease PDZ domain SH3_1 PF00018.28 EMC77305.1 - 0.0017 17.9 0.0 0.0043 16.6 0.0 1.8 1 0 0 1 1 1 1 SH3 domain PID PF00640.23 EMC77306.1 - 1.4e-44 151.5 0.2 2.1e-44 150.9 0.2 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PDZ PF00595.24 EMC77306.1 - 2.2e-28 98.4 3.8 5.1e-14 52.4 0.1 2.6 3 0 0 3 3 3 2 PDZ domain PDZ_6 PF17820.1 EMC77306.1 - 5.6e-16 58.1 1.0 1.1e-07 31.6 0.1 3.2 4 0 0 4 4 4 2 PDZ domain PDZ_2 PF13180.6 EMC77306.1 - 2.3e-06 27.8 0.0 0.00051 20.3 0.0 2.5 2 0 0 2 2 2 1 PDZ domain DUF993 PF06187.11 EMC77306.1 - 0.0016 17.4 0.2 0.0022 16.9 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF993) NRho PF16733.5 EMC77306.1 - 0.017 15.1 0.3 0.073 13.1 0.1 2.0 2 0 0 2 2 2 0 Rhomboid N-terminal domain LysM PF01476.20 EMC77306.1 - 0.16 12.0 0.0 0.43 10.7 0.0 1.8 1 0 0 1 1 1 0 LysM domain DUF1435 PF07256.12 EMC77306.1 - 0.21 11.7 0.7 0.46 10.6 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1435) FAD-oxidase_C PF02913.19 EMC77307.1 - 2.2e-58 197.9 0.0 2.9e-58 197.4 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EMC77307.1 - 3.6e-37 127.2 0.0 1.3e-36 125.4 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain bZIP_Maf PF03131.17 EMC77308.1 - 1.3e-16 60.9 4.1 1.3e-16 60.9 4.1 2.4 2 0 0 2 2 2 1 bZIP Maf transcription factor bZIP_1 PF00170.21 EMC77308.1 - 1.1e-08 35.1 12.2 1.1e-08 35.1 12.2 2.3 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EMC77308.1 - 6.7e-05 22.9 9.4 6.7e-05 22.9 9.4 2.5 2 0 0 2 2 2 1 Basic region leucine zipper RRM_1 PF00076.22 EMC77309.1 - 8.2e-36 121.7 0.2 1.6e-16 59.9 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMC77309.1 - 4.5e-10 39.5 0.3 2.4e-05 24.3 0.2 2.4 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EMC77309.1 - 0.00059 19.8 0.2 0.058 13.4 0.2 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 EMC77309.1 - 0.034 14.4 0.2 0.082 13.1 0.2 1.7 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter RRM_3 PF08777.11 EMC77309.1 - 0.12 12.4 0.7 0.7 10.0 0.5 2.0 2 0 0 2 2 2 0 RNA binding motif Tom37 PF10568.9 EMC77310.1 - 2.9e-30 105.1 0.1 1.1e-29 103.3 0.0 1.8 2 0 0 2 2 2 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 EMC77310.1 - 8.8e-25 87.3 0.0 2.1e-24 86.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 EMC77310.1 - 6.4e-24 83.5 0.2 1.8e-23 82.1 0.2 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EMC77310.1 - 2e-06 27.7 0.0 5.1e-06 26.4 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain TRADD_N PF09034.10 EMC77310.1 - 0.055 13.5 0.0 0.26 11.4 0.0 2.1 2 0 0 2 2 2 0 TRADD, N-terminal domain GST_C_3 PF14497.6 EMC77310.1 - 0.072 13.3 0.1 0.23 11.7 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Homeodomain PF00046.29 EMC77311.1 - 2.7e-22 78.4 9.1 5e-22 77.5 9.1 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC77311.1 - 0.068 13.1 0.9 0.14 12.1 0.9 1.5 1 0 0 1 1 1 0 Homeobox KN domain DUF2209 PF09974.9 EMC77311.1 - 0.076 13.3 0.1 0.11 12.8 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Homeodomain PF00046.29 EMC77312.1 - 1.3e-21 76.2 5.5 1.4e-21 76.1 5.5 1.0 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC77312.1 - 0.00052 19.9 0.1 0.00066 19.5 0.1 1.2 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EMC77313.1 - 3.9e-10 39.4 2.1 1.4e-09 37.7 0.4 2.2 2 0 0 2 2 2 1 Homeodomain DUF3528 PF12045.8 EMC77314.1 - 2.3e-54 183.9 1.0 4.1e-54 183.1 1.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3528) Homeodomain PF00046.29 EMC77314.1 - 2.2e-20 72.3 8.3 3.9e-20 71.4 8.3 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC77314.1 - 0.06 13.3 2.3 0.068 13.1 0.6 2.0 2 0 0 2 2 2 0 Homeobox KN domain DUF3544 PF12064.8 EMC77314.1 - 0.12 12.6 4.2 0.19 12.0 4.2 1.2 1 0 0 1 1 1 0 Protein kinase C-binding protein 1 MerR_1 PF13411.6 EMC77314.1 - 0.19 11.8 0.6 1.1 9.4 0.1 2.1 1 1 1 2 2 2 0 MerR HTH family regulatory protein Homeodomain PF00046.29 EMC77315.1 - 4.2e-19 68.2 10.8 8.4e-19 67.2 10.8 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC77315.1 - 0.022 14.6 2.2 0.051 13.5 2.2 1.7 1 1 0 1 1 1 0 Homeobox KN domain Homez PF11569.8 EMC77315.1 - 0.026 14.0 0.2 0.048 13.1 0.2 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Homeodomain PF00046.29 EMC77316.1 - 4.1e-19 68.2 6.1 5e-19 67.9 6.1 1.1 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC77316.1 - 0.00029 20.7 3.4 0.00049 20.0 3.4 1.6 1 1 0 1 1 1 1 Homeobox KN domain DUF1510 PF07423.11 EMC77316.1 - 0.035 14.2 0.1 0.043 14.0 0.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF1510) HTH_23 PF13384.6 EMC77316.1 - 0.055 13.3 0.1 0.081 12.8 0.1 1.3 1 0 0 1 1 1 0 Homeodomain-like domain zinc_ribbon_10 PF10058.9 EMC77318.1 - 2.1e-21 75.4 0.3 3.2e-21 74.8 0.3 1.3 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein 7tm_7 PF08395.12 EMC77318.1 - 0.00046 19.5 0.3 0.0006 19.1 0.3 1.1 1 0 0 1 1 1 1 7tm Chemosensory receptor DUF4153 PF13687.6 EMC77318.1 - 0.0028 17.3 0.3 0.0049 16.5 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4153) DUF2207 PF09972.9 EMC77318.1 - 0.005 15.7 0.2 0.0067 15.2 0.2 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) XK-related PF09815.9 EMC77318.1 - 0.011 14.9 0.5 0.015 14.4 0.5 1.1 1 0 0 1 1 1 0 XK-related protein ATP-synt_C PF00137.21 EMC77319.1 - 1.5e-11 44.4 12.4 2.4e-11 43.8 12.4 1.3 1 0 0 1 1 1 1 ATP synthase subunit C bZIP_1 PF00170.21 EMC77320.1 - 3.1e-12 46.4 7.0 5e-12 45.7 7.0 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMC77320.1 - 4.1e-09 36.4 7.7 9.3e-09 35.2 7.7 1.6 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EMC77320.1 - 0.0043 17.5 7.7 0.011 16.2 7.7 1.7 1 0 0 1 1 1 1 bZIP Maf transcription factor zf-C2H2 PF00096.26 EMC77320.1 - 0.028 14.9 1.5 0.054 14.0 1.5 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type KxDL PF10241.9 EMC77320.1 - 0.77 10.1 3.0 2.1 8.7 1.8 2.2 3 0 0 3 3 3 0 Uncharacterized conserved protein RhoGAP PF00620.27 EMC77321.1 - 2.8e-50 170.1 0.0 5.1e-50 169.2 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.22 EMC77321.1 - 4.1e-16 58.6 7.5 7.2e-16 57.8 7.5 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH2 PF00017.24 EMC77321.1 - 4.7e-13 49.0 0.1 1.1e-12 47.8 0.1 1.6 1 0 0 1 1 1 1 SH2 domain FYVE_2 PF02318.16 EMC77321.1 - 0.042 14.1 2.0 0.081 13.1 2.0 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger PHD_2 PF13831.6 EMC77321.1 - 0.069 12.7 1.6 0.15 11.6 1.6 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 EMC77321.1 - 0.29 11.5 5.1 0.6 10.5 5.1 1.5 1 0 0 1 1 1 0 RING-like domain PHD PF00628.29 EMC77321.1 - 3.1 7.8 7.6 6.2 6.8 7.6 1.5 1 0 0 1 1 1 0 PHD-finger Neur_chan_LBD PF02931.23 EMC77322.1 - 3.4e-71 239.1 1.6 4.5e-71 238.7 1.6 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC77322.1 - 1.6e-67 228.1 11.9 6.1e-52 177.1 9.6 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region DUF5336 PF17270.2 EMC77322.1 - 0.09 12.4 0.4 0.16 11.6 0.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5336) DUF2207 PF09972.9 EMC77322.1 - 1.2 7.8 4.8 23 3.6 0.0 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF1129 PF06570.11 EMC77322.1 - 10 5.6 9.1 21 4.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Mem_trans PF03547.18 EMC77323.1 - 5.2e-19 67.9 31.0 9.1e-14 50.6 6.5 3.1 2 1 1 3 3 3 2 Membrane transport protein DEP PF00610.21 EMC77323.1 - 2.1e-12 46.9 0.0 4.5e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Cir_N PF10197.9 EMC77324.1 - 4.8e-05 23.5 4.6 4.8e-05 23.5 4.6 4.1 5 0 0 5 5 5 1 N-terminal domain of CBF1 interacting co-repressor CIR Prok_Ub PF14454.6 EMC77325.1 - 0.0019 17.8 0.3 29 4.4 0.0 4.2 2 1 3 5 5 5 3 Prokaryotic Ubiquitin DUF4614 PF15391.6 EMC77325.1 - 0.025 14.6 3.9 12 5.9 0.2 3.6 2 1 2 4 4 4 0 Domain of unknown function (DUF4614) Pkinase PF00069.25 EMC77326.1 - 4.5e-34 118.0 1.5 4.9e-34 117.9 1.5 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC77326.1 - 4.8e-14 52.3 0.2 6.2e-14 51.9 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EMC77326.1 - 6.8e-05 22.9 0.2 0.039 13.9 0.5 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family ABC1 PF03109.16 EMC77326.1 - 0.014 15.6 0.0 0.027 14.7 0.0 1.4 1 0 0 1 1 1 0 ABC1 family FTA2 PF13095.6 EMC77326.1 - 0.054 13.1 0.5 0.46 10.1 0.3 2.3 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EMC77326.1 - 0.087 12.2 0.7 0.12 11.7 0.7 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Arrestin_C PF02752.22 EMC77327.1 - 5.6e-22 78.6 0.0 3.2e-21 76.2 0.0 1.9 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EMC77327.1 - 5.2e-19 68.7 0.0 1.4e-17 64.1 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Vps26 PF03643.15 EMC77327.1 - 0.1 11.6 0.0 0.16 10.9 0.0 1.4 1 1 0 1 1 1 0 Vacuolar protein sorting-associated protein 26 Rgp1 PF08737.10 EMC77327.1 - 0.12 11.5 0.1 0.21 10.7 0.1 1.3 1 0 0 1 1 1 0 Rgp1 Peptidase_C15 PF01470.17 EMC77328.1 - 1.5e-18 67.7 0.0 2e-18 67.3 0.0 1.0 1 0 0 1 1 1 1 Pyroglutamyl peptidase PgaPase_1 PF06162.12 EMC77328.1 - 9.8e-05 22.2 0.0 0.00013 21.7 0.0 1.1 1 0 0 1 1 1 1 Putative pyroglutamyl peptidase PgaPase_1 Pkinase_Tyr PF07714.17 EMC77329.1 - 4.1e-95 318.0 0.0 6e-95 317.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.24 EMC77329.1 - 1.1e-58 196.2 5.4 1.4e-29 102.5 0.7 2.4 2 0 0 2 2 2 2 Receptor L domain Pkinase PF00069.25 EMC77329.1 - 3.1e-40 138.2 0.0 4.9e-40 137.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.20 EMC77329.1 - 8.9e-40 136.0 42.5 8.9e-40 136.0 42.5 2.0 2 0 0 2 2 2 1 Furin-like cysteine rich region fn3 PF00041.21 EMC77329.1 - 1.4e-19 70.2 6.4 7.6e-07 29.4 0.1 4.7 4 0 0 4 4 4 4 Fibronectin type III domain Kinase-like PF14531.6 EMC77329.1 - 0.00085 18.7 0.0 0.0015 17.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Insulin_TMD PF17870.1 EMC77329.1 - 0.02 14.9 0.4 0.049 13.7 0.4 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Filament PF00038.21 EMC77330.1 - 2.1e-12 47.3 41.4 1.6e-08 34.6 10.6 4.1 3 1 1 4 4 4 2 Intermediate filament protein L27_2 PF09045.10 EMC77330.1 - 0.0049 16.8 0.3 0.021 14.8 0.3 2.1 1 0 0 1 1 1 1 L27_2 DUF568 PF04526.13 EMC77330.1 - 0.027 15.2 0.7 0.18 12.6 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF568) HisKA PF00512.25 EMC77330.1 - 0.89 9.6 4.5 4.3 7.5 4.5 2.2 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain LRR_8 PF13855.6 EMC77331.1 - 2e-24 85.1 31.4 1.6e-11 43.8 1.7 4.6 1 1 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EMC77331.1 - 2.4e-16 59.6 19.9 1.3e-06 28.6 0.5 5.9 2 1 1 6 6 6 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC77331.1 - 9.3e-05 22.5 14.8 24 6.0 0.0 8.2 8 1 0 8 8 8 2 Leucine Rich Repeat LRR_9 PF14580.6 EMC77331.1 - 0.00034 20.2 9.2 0.002 17.6 1.1 3.0 2 1 0 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.6 EMC77331.1 - 0.12 12.4 11.4 25 5.3 0.1 6.4 6 0 0 6 6 6 0 Leucine Rich repeat SRF-TF PF00319.18 EMC77332.1 - 5.6e-24 83.4 0.4 9.4e-24 82.6 0.4 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.8 EMC77332.1 - 3.5e-07 30.2 0.0 3.5e-07 30.2 0.0 2.9 4 0 0 4 4 4 1 Holliday junction regulator protein family C-terminal repeat GHD PF17834.1 EMC77332.1 - 0.13 12.3 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Beta-sandwich domain in beta galactosidase LysM PF01476.20 EMC77333.1 - 0.0057 16.7 0.0 0.0095 16.0 0.0 1.4 1 0 0 1 1 1 1 LysM domain TSP_1 PF00090.19 EMC77334.1 - 2.6e-25 88.4 85.5 1.5e-10 41.1 10.3 7.2 6 1 0 6 6 5 4 Thrombospondin type 1 domain ADAM_CR_2 PF17771.1 EMC77334.1 - 1.4e-22 80.0 12.7 9.2e-21 74.2 6.6 7.4 6 2 1 7 7 5 2 ADAM cysteine-rich domain Reprolysin PF01421.19 EMC77334.1 - 8.4e-21 74.8 0.7 8.9e-16 58.4 0.2 2.8 2 0 0 2 2 2 2 Reprolysin (M12B) family zinc metalloprotease ADAM_spacer1 PF05986.14 EMC77334.1 - 3.4e-15 56.1 0.0 6.4e-15 55.2 0.0 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Reprolysin_5 PF13688.6 EMC77334.1 - 6.1e-13 49.4 1.0 2.2e-12 47.6 1.0 1.9 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EMC77334.1 - 1.2e-10 41.9 0.0 2.6e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EMC77334.1 - 2.7e-07 30.7 0.9 9.5e-07 28.9 0.9 1.9 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EMC77334.1 - 1.1e-05 25.1 0.3 7.6e-05 22.4 0.1 2.1 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like PLAC PF08686.11 EMC77334.1 - 0.0026 18.5 9.4 0.0026 18.5 9.4 3.2 2 0 0 2 2 2 1 PLAC (protease and lacunin) domain Peptidase_M10 PF00413.24 EMC77334.1 - 0.0052 16.6 0.0 0.0084 16.0 0.0 1.3 1 0 0 1 1 1 1 Matrixin Peptidase_M66 PF10462.9 EMC77334.1 - 0.13 11.2 0.2 0.27 10.1 0.2 1.4 1 0 0 1 1 1 0 Peptidase M66 Phage_G PF02306.15 EMC77335.1 - 0.0052 16.5 13.9 21 4.8 0.2 6.7 2 2 4 7 7 7 4 Major spike protein (G protein) Transposase_24 PF03004.14 EMC77335.1 - 0.059 13.5 1.4 32 4.6 0.0 3.9 3 1 1 5 5 5 0 Plant transposase (Ptta/En/Spm family) CUT PF02376.15 EMC77335.1 - 0.5 10.6 4.4 14 5.9 0.2 3.8 3 2 0 3 3 3 0 CUT domain CH PF00307.31 EMC77336.1 - 9e-15 54.8 0.7 1.6e-14 54.0 0.1 1.8 2 0 0 2 2 1 1 Calponin homology (CH) domain AAA_14 PF13173.6 EMC77336.1 - 1.3e-05 25.3 0.0 3.7e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EMC77336.1 - 2.8e-05 24.6 0.1 9.7e-05 22.8 0.0 2.0 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EMC77336.1 - 5.8e-05 23.4 0.1 0.0037 17.6 0.1 2.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EMC77336.1 - 0.00011 22.6 0.2 0.034 14.5 0.0 3.0 1 1 1 2 2 2 1 AAA ATPase domain CAMSAP_CH PF11971.8 EMC77336.1 - 0.00081 19.2 0.2 0.0083 15.9 0.0 2.4 2 0 0 2 2 2 1 CAMSAP CH domain RNA_helicase PF00910.22 EMC77336.1 - 0.0021 18.4 0.0 0.01 16.2 0.0 2.2 2 0 0 2 2 1 1 RNA helicase PhoH PF02562.16 EMC77336.1 - 0.003 17.1 0.0 0.0065 16.0 0.0 1.5 1 0 0 1 1 1 1 PhoH-like protein IstB_IS21 PF01695.17 EMC77336.1 - 0.0093 15.7 0.0 0.02 14.6 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein ResIII PF04851.15 EMC77336.1 - 0.012 15.6 0.1 0.29 11.1 0.1 2.7 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit AAA_18 PF13238.6 EMC77336.1 - 0.013 16.0 0.0 0.053 14.1 0.0 2.1 2 0 0 2 2 1 0 AAA domain AAA_28 PF13521.6 EMC77336.1 - 0.016 15.5 0.0 0.034 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EMC77336.1 - 0.017 14.2 0.0 0.037 13.1 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_5 PF07728.14 EMC77336.1 - 0.019 14.9 0.0 0.056 13.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EMC77336.1 - 0.021 14.6 0.0 0.041 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 EMC77336.1 - 0.022 14.9 0.0 0.056 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_25 PF13481.6 EMC77336.1 - 0.025 14.2 0.0 0.14 11.7 0.0 2.0 1 1 1 2 2 2 0 AAA domain CH_2 PF06294.11 EMC77336.1 - 0.032 14.4 0.2 0.13 12.4 0.0 2.1 2 0 0 2 2 2 0 CH-like domain in sperm protein Mg_chelatase PF01078.21 EMC77336.1 - 0.048 13.0 0.0 0.15 11.4 0.0 1.8 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 EMC77336.1 - 0.051 13.9 0.0 0.14 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EMC77336.1 - 0.065 13.1 0.0 1.1 9.2 0.0 2.7 2 0 0 2 2 2 0 RsgA GTPase NACHT PF05729.12 EMC77336.1 - 0.091 12.7 0.0 0.23 11.3 0.0 1.7 1 0 0 1 1 1 0 NACHT domain DivIC PF04977.15 EMC77336.1 - 0.12 12.2 13.0 2.2 8.1 0.1 4.4 4 0 0 4 4 4 0 Septum formation initiator ZapB PF06005.12 EMC77336.1 - 1.9 9.0 12.6 14 6.2 0.1 4.2 2 1 0 2 2 2 0 Cell division protein ZapB DUF4201 PF13870.6 EMC77336.1 - 2.7 7.7 16.8 0.89 9.3 4.8 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) GrpE PF01025.19 EMC77336.1 - 4.4 6.9 9.9 8.2 6.1 0.6 2.8 2 0 0 2 2 2 0 GrpE Ank_2 PF12796.7 EMC77337.1 - 1.5e-49 166.5 25.2 3.1e-16 59.7 2.4 3.1 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC77337.1 - 9.8e-33 111.8 7.0 3.4e-11 43.2 0.0 5.6 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC77337.1 - 1.4e-28 98.9 12.5 6.5e-09 36.2 0.3 4.4 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC77337.1 - 3.7e-24 82.1 6.2 2.8e-05 24.1 0.1 6.3 6 0 0 6 6 6 6 Ankyrin repeat Ank PF00023.30 EMC77337.1 - 5.5e-24 83.5 9.6 1.7e-08 34.5 0.1 6.2 6 0 0 6 6 6 5 Ankyrin repeat Death PF00531.22 EMC77337.1 - 3.2e-06 27.2 0.2 8.9e-06 25.8 0.0 1.8 2 0 0 2 2 2 1 Death domain VWA_3_C PF18571.1 EMC77337.1 - 0.055 13.3 0.5 0.7 9.8 0.1 2.9 4 0 0 4 4 4 0 von Willebrand factor type A C-terminal domain Abhydrolase_1 PF00561.20 EMC77338.1 - 2.7e-08 33.8 0.0 3.6e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMC77338.1 - 1.5e-06 29.0 0.0 2e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMC77338.1 - 0.0016 17.8 0.0 0.0023 17.2 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 EMC77338.1 - 0.0043 15.8 0.0 0.0063 15.2 0.0 1.2 1 0 0 1 1 1 1 Ndr family Thioesterase PF00975.20 EMC77338.1 - 0.0084 16.3 0.1 0.015 15.4 0.1 1.4 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_5 PF12695.7 EMC77338.1 - 0.084 12.6 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 EMC77338.1 - 0.16 11.8 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold AAA_2 PF07724.14 EMC77339.1 - 1.9e-41 142.0 0.0 3.2e-41 141.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.9 EMC77339.1 - 4e-15 55.6 0.0 9.6e-15 54.4 0.0 1.6 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 EMC77339.1 - 1.1e-13 51.7 0.0 2.1e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EMC77339.1 - 1.2e-05 25.3 0.0 3.1e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EMC77339.1 - 2.4e-05 24.1 0.0 0.0002 21.1 0.0 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_7 PF12775.7 EMC77339.1 - 6.8e-05 22.5 0.0 0.00012 21.7 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region Mg_chelatase PF01078.21 EMC77339.1 - 9.2e-05 21.9 0.0 0.011 15.2 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 EMC77339.1 - 0.00028 21.2 0.1 0.001 19.3 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EMC77339.1 - 0.0026 18.1 0.0 0.0075 16.7 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 EMC77339.1 - 0.0059 16.6 0.0 0.013 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EMC77339.1 - 0.0067 16.2 0.0 0.016 15.0 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activ_2 PF14532.6 EMC77339.1 - 0.0069 16.5 0.0 0.016 15.3 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain IstB_IS21 PF01695.17 EMC77339.1 - 0.008 15.9 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein T2SSE PF00437.20 EMC77339.1 - 0.0086 15.2 0.0 0.014 14.5 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein TsaE PF02367.17 EMC77339.1 - 0.022 14.7 0.0 0.042 13.9 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EMC77339.1 - 0.026 14.5 0.3 0.074 13.0 0.3 1.9 1 1 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 EMC77339.1 - 0.057 13.1 0.0 0.097 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EMC77339.1 - 0.061 13.8 0.1 0.17 12.4 0.0 1.8 2 0 0 2 2 1 0 ABC transporter AAA_18 PF13238.6 EMC77339.1 - 0.071 13.7 0.0 0.21 12.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 EMC77339.1 - 0.1 11.8 0.0 0.19 10.9 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain PduV-EutP PF10662.9 EMC77339.1 - 0.15 11.8 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 EMC77339.1 - 0.16 12.4 0.0 0.77 10.2 0.0 2.2 3 0 0 3 3 1 0 RNA helicase AAA_29 PF13555.6 EMC77339.1 - 0.17 11.7 0.0 0.42 10.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain MCM PF00493.23 EMC77339.1 - 0.17 11.0 0.1 0.3 10.2 0.1 1.3 1 0 0 1 1 1 0 MCM P-loop domain zinc_ribbon_4 PF13717.6 EMC77339.1 - 0.2 11.6 4.9 9.1 6.3 0.2 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 EMC77339.1 - 0.47 10.5 4.4 0.91 9.6 4.4 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Ribosomal_S27e PF01667.17 EMC77339.1 - 0.68 9.7 4.3 2.4 8.0 3.9 2.1 2 0 0 2 2 2 0 Ribosomal protein S27 PDCD7 PF16021.5 EMC77340.1 - 7.1e-95 317.7 17.5 7.9e-95 317.5 17.5 1.0 1 0 0 1 1 1 1 Programmed cell death protein 7 DUF1367 PF07105.11 EMC77340.1 - 0.051 13.2 0.5 0.071 12.8 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1367) CENP-Q PF13094.6 EMC77340.1 - 0.28 11.4 22.9 0.12 12.6 8.2 2.1 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Rotamase_3 PF13616.6 EMC77340.1 - 9.1 6.9 8.2 1.9 9.0 2.1 2.7 1 1 1 2 2 2 0 PPIC-type PPIASE domain UBA PF00627.31 EMC77342.1 - 1.2e-05 25.0 0.6 0.0027 17.6 0.0 2.2 2 0 0 2 2 2 2 UBA/TS-N domain Sigma54_CBD PF04963.13 EMC77342.1 - 0.01 15.7 0.3 0.011 15.6 0.3 1.1 1 0 0 1 1 1 0 Sigma-54 factor, core binding domain WIYLD PF10440.9 EMC77342.1 - 0.02 14.7 0.0 2.3 8.1 0.0 2.7 1 1 2 3 3 3 0 Ubiquitin-binding WIYLD domain UBA_3 PF09288.10 EMC77342.1 - 0.043 13.6 1.6 1.1 9.1 1.0 2.5 2 1 0 2 2 2 0 Fungal ubiquitin-associated domain Raf1_HTH PF18579.1 EMC77342.1 - 0.1 12.3 0.3 3.1 7.6 0.0 2.2 1 1 1 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain Kelch_1 PF01344.25 EMC77343.1 - 1.8e-21 75.4 13.6 9.3e-10 37.9 0.0 6.1 7 0 0 7 7 7 4 Kelch motif Kelch_6 PF13964.6 EMC77343.1 - 1.2e-16 60.3 2.4 8.9e-07 29.0 0.0 5.0 3 2 1 4 4 4 3 Kelch motif Kelch_4 PF13418.6 EMC77343.1 - 8.3e-11 41.7 3.9 4.8e-05 23.3 0.0 4.9 4 1 1 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EMC77343.1 - 8.6e-11 41.4 1.7 0.0019 18.1 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 EMC77343.1 - 2.1e-06 27.9 0.6 0.042 14.2 0.0 5.0 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC77343.1 - 0.00089 19.2 3.9 1.5 8.9 0.1 3.7 3 0 0 3 3 3 2 Kelch motif DUF1668 PF07893.13 EMC77343.1 - 0.009 15.4 0.3 0.72 9.1 0.0 2.4 1 1 1 2 2 2 1 Protein of unknown function (DUF1668) OSTbeta PF15048.6 EMC77344.1 - 3.3e-32 111.2 0.0 4.3e-32 110.8 0.0 1.1 1 0 0 1 1 1 1 Organic solute transporter subunit beta protein Saf_2TM PF18303.1 EMC77344.1 - 0.0041 16.7 0.0 0.005 16.4 0.0 1.1 1 0 0 1 1 1 1 SAVED-fused 2TM effector domain Tad PF13400.6 EMC77344.1 - 0.049 13.9 0.1 0.11 12.8 0.1 1.6 1 0 0 1 1 1 0 Putative Flp pilus-assembly TadE/G-like DUF2474 PF10617.9 EMC77344.1 - 0.053 13.4 0.7 0.089 12.7 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2474) DUF5472 PF17566.2 EMC77344.1 - 0.082 12.9 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5472) MHYT PF03707.16 EMC77344.1 - 0.092 12.9 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial signalling protein N terminal repeat Formyl_trans_N PF00551.19 EMC77345.1 - 3.8e-25 88.7 0.0 7.1e-25 87.8 0.0 1.4 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 EMC77345.1 - 1e-11 45.0 0.3 4.1e-11 43.0 0.0 2.1 3 0 0 3 3 3 1 Formyl transferase, C-terminal domain Ig_3 PF13927.6 EMC77346.1 - 1.6e-12 47.8 0.0 6.8e-12 45.8 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 EMC77346.1 - 1.3e-10 41.5 0.0 3.4e-10 40.1 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain CarbopepD_reg_2 PF13715.6 EMC77346.1 - 1.9e-09 37.4 0.0 0.00013 21.9 0.0 2.8 2 0 0 2 2 2 2 CarboxypepD_reg-like domain CarboxypepD_reg PF13620.6 EMC77346.1 - 7.9e-09 35.7 0.5 8.7e-08 32.3 0.0 2.7 3 0 0 3 3 3 1 Carboxypeptidase regulatory-like domain I-set PF07679.16 EMC77346.1 - 2.8e-08 33.7 0.0 7.8e-08 32.3 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC77346.1 - 5.5e-07 29.7 0.0 2.9e-06 27.3 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain TSP_1 PF00090.19 EMC77346.1 - 4e-06 26.9 10.3 4e-06 26.9 10.3 2.9 3 0 0 3 3 3 1 Thrombospondin type 1 domain bMG3 PF11974.8 EMC77346.1 - 0.074 13.1 0.1 0.31 11.1 0.0 2.0 2 0 0 2 2 2 0 Bacterial alpha-2-macroglobulin MG3 domain 7tm_1 PF00001.21 EMC77347.1 - 2.4e-49 168.0 9.8 3.2e-49 167.6 9.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC77347.1 - 4.4e-07 29.5 6.5 5.9e-07 29.1 6.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx PARP PF00644.20 EMC77348.1 - 1.2e-32 113.1 0.0 1.5e-32 112.8 0.0 1.1 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain ARTD15_N PF18084.1 EMC77348.1 - 3.3e-23 81.7 0.0 6.2e-23 80.9 0.0 1.5 1 0 0 1 1 1 1 ARTD15 N-terminal domain SdpI PF13630.6 EMC77348.1 - 0.018 15.2 0.1 0.036 14.2 0.1 1.4 1 0 0 1 1 1 0 SdpI/YhfL protein family I-set PF07679.16 EMC77349.1 - 1.1e-59 198.5 0.0 1.4e-21 76.3 0.0 4.9 5 0 0 5 5 5 4 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC77349.1 - 3.6e-53 178.1 0.0 3.2e-15 56.5 0.1 4.7 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 EMC77349.1 - 2.8e-33 114.1 0.0 8.5e-08 32.4 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 EMC77349.1 - 4.1e-30 103.8 0.0 9.2e-09 35.4 0.0 5.0 4 1 0 4 4 4 4 Immunoglobulin domain fn3 PF00041.21 EMC77349.1 - 1.2e-23 83.2 3.5 1.1e-13 51.3 0.4 2.9 2 0 0 2 2 2 2 Fibronectin type III domain V-set PF07686.17 EMC77349.1 - 6.9e-19 68.0 2.3 5.6e-05 23.3 0.0 6.7 4 3 1 5 5 5 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC77349.1 - 2.3e-13 50.0 0.2 1.7e-06 28.0 0.1 4.9 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 EMC77349.1 - 9.3e-07 29.1 0.3 0.03 14.7 0.0 3.7 5 0 0 5 5 4 2 Immunoglobulin C1-set domain Pur_ac_phosph_N PF16656.5 EMC77349.1 - 0.00028 21.4 1.6 0.0011 19.4 1.6 2.1 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Ig_C17orf99 PF17736.1 EMC77349.1 - 0.0008 19.4 0.3 0.013 15.5 0.0 3.3 4 0 0 4 4 4 1 C17orf99 Ig domain Ig_6 PF18452.1 EMC77349.1 - 0.0013 18.3 0.0 1.4 8.6 0.0 3.5 4 0 0 4 4 4 1 Immunoglobulin domain C2-set PF05790.15 EMC77349.1 - 0.0027 17.9 0.0 40 4.5 0.0 4.2 4 0 0 4 4 4 0 Immunoglobulin C2-set domain BiPBP_C PF06832.12 EMC77349.1 - 0.018 15.0 0.0 3.7 7.7 0.0 2.8 2 0 0 2 2 2 0 Penicillin-Binding Protein C-terminus Family Interfer-bind PF09294.10 EMC77349.1 - 0.038 14.3 0.3 0.11 12.8 0.3 1.8 1 0 0 1 1 1 0 Interferon-alpha/beta receptor, fibronectin type III Adeno_E3_CR2 PF02439.15 EMC77349.1 - 0.31 10.8 4.1 0.77 9.6 4.1 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DPPIV_N PF00930.21 EMC77350.1 - 9.5e-99 330.5 0.0 1.3e-98 330.1 0.0 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EMC77350.1 - 1.6e-60 204.2 0.0 2.8e-60 203.4 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EMC77350.1 - 5.1e-08 32.8 0.0 9.1e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 EMC77350.1 - 0.00071 20.2 0.0 0.0015 19.1 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EMC77350.1 - 0.034 13.8 1.2 0.074 12.7 1.2 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EMC77350.1 - 0.05 13.4 0.0 1.4 8.7 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Esterase PF00756.20 EMC77350.1 - 0.082 12.5 0.1 0.34 10.5 0.1 1.9 1 1 0 1 1 1 0 Putative esterase Abhydrolase_4 PF08386.10 EMC77350.1 - 0.12 12.5 0.0 0.38 10.9 0.0 1.8 1 0 0 1 1 1 0 TAP-like protein Abhydrolase_3 PF07859.13 EMC77350.1 - 0.18 11.6 0.0 0.43 10.4 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold Na_Ca_ex PF01699.24 EMC77351.1 - 2.6e-58 196.3 48.4 7.1e-31 107.2 24.1 2.8 3 0 0 3 3 3 2 Sodium/calcium exchanger protein FAM177 PF14774.6 EMC77351.1 - 0.084 13.2 0.3 0.23 11.8 0.3 1.7 1 0 0 1 1 1 0 FAM177 family AF-4 PF05110.13 EMC77351.1 - 0.22 9.6 14.8 0.3 9.1 14.8 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein CENP-B_dimeris PF09026.10 EMC77351.1 - 0.26 11.7 10.1 0.63 10.5 10.1 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM60A PF15396.6 EMC77351.1 - 0.78 9.7 2.1 2 8.4 2.1 1.6 1 0 0 1 1 1 0 Protein Family FAM60A PPP4R2 PF09184.11 EMC77351.1 - 1.6 8.3 13.1 2.3 7.7 13.1 1.2 1 0 0 1 1 1 0 PPP4R2 Nop14 PF04147.12 EMC77351.1 - 1.9 6.6 12.1 3 6.0 12.1 1.3 1 0 0 1 1 1 0 Nop14-like family PBP1_TM PF14812.6 EMC77351.1 - 4.8 7.6 9.4 0.28 11.6 3.3 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Dicty_REP PF05086.12 EMC77351.1 - 4.9 5.0 4.9 7.1 4.5 4.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein TFIIA PF03153.13 EMC77351.1 - 5.6 6.8 16.2 10 6.0 16.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SAPS PF04499.15 EMC77351.1 - 7.1 5.3 6.0 9.7 4.8 6.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DENN PF02141.21 EMC77352.1 - 1.7e-59 200.9 3.8 1.7e-59 200.9 3.8 2.0 2 0 0 2 2 2 1 DENN (AEX-3) domain uDENN PF03456.18 EMC77352.1 - 6.4e-17 62.1 0.1 2.9e-16 60.0 0.1 2.3 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 EMC77352.1 - 4.6e-14 52.1 5.3 4.6e-14 52.1 5.3 2.2 2 0 0 2 2 2 1 dDENN domain PPR_2 PF13041.6 EMC77352.1 - 6.7e-07 29.4 0.0 2e-05 24.7 0.0 2.6 1 1 1 2 2 2 2 PPR repeat family PPR_3 PF13812.6 EMC77352.1 - 0.00018 21.6 0.4 0.001 19.1 0.1 2.4 2 1 1 3 3 3 2 Pentatricopeptide repeat domain PPR_long PF17177.4 EMC77352.1 - 0.0003 20.2 0.0 0.0022 17.4 0.0 2.3 2 0 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 EMC77352.1 - 0.008 16.4 0.0 0.054 13.8 0.0 2.4 2 0 0 2 2 2 1 PPR repeat Papo_T_antigen PF02380.15 EMC77352.1 - 0.45 10.7 5.6 0.16 12.1 1.0 2.5 2 0 0 2 2 2 0 T-antigen specific domain Ras PF00071.22 EMC77353.1 - 1.3e-62 210.2 0.1 1.5e-62 210.0 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC77353.1 - 1.3e-34 119.0 0.1 2.4e-34 118.1 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC77353.1 - 2.5e-11 43.4 0.1 2.9e-11 43.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC77353.1 - 3.5e-07 30.3 0.0 5.8e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EMC77353.1 - 3.6e-05 24.1 0.1 0.00041 20.6 0.0 2.3 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EMC77353.1 - 5e-05 23.3 0.1 0.023 14.6 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EMC77353.1 - 0.00015 21.4 0.1 0.00034 20.2 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EMC77353.1 - 0.0073 16.7 0.1 0.013 15.9 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain Gtr1_RagA PF04670.12 EMC77353.1 - 0.03 13.7 0.0 0.045 13.1 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 EMC77353.1 - 0.03 13.9 0.1 0.11 12.1 0.1 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B ABC_tran PF00005.27 EMC77353.1 - 0.034 14.7 0.1 0.046 14.2 0.1 1.6 1 1 0 1 1 1 0 ABC transporter AAA_14 PF13173.6 EMC77353.1 - 0.044 13.8 0.1 0.11 12.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.10 EMC77353.1 - 0.075 12.5 0.0 0.12 11.8 0.0 1.6 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit TniB PF05621.11 EMC77353.1 - 0.078 12.4 0.3 0.23 10.8 0.0 2.2 2 1 0 2 2 2 0 Bacterial TniB protein FAD-SLDH PF12318.8 EMC77353.1 - 0.084 12.9 0.2 0.2 11.7 0.1 1.6 2 0 0 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase PduV-EutP PF10662.9 EMC77353.1 - 0.09 12.5 0.0 0.24 11.1 0.0 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_21 PF13304.6 EMC77353.1 - 0.16 11.8 0.8 0.3 10.9 0.5 1.5 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Laminin_EGF PF00053.24 EMC77354.1 - 2.6e-52 174.7 298.9 0.00038 20.5 15.8 16.7 6 4 10 16 16 16 16 Laminin EGF domain hEGF PF12661.7 EMC77354.1 - 1.5e-09 38.1 267.8 0.00017 22.1 5.4 21.9 23 2 0 23 23 19 13 Human growth factor-like EGF EGF_2 PF07974.13 EMC77354.1 - 1.9e-07 31.3 377.7 0.0079 16.6 10.1 25.8 21 7 3 24 24 24 11 EGF-like domain EGF PF00008.27 EMC77354.1 - 0.0059 16.9 34.1 0.0072 16.6 13.2 22.0 23 1 0 23 23 22 12 EGF-like domain Syndecan PF01034.20 EMC77354.1 - 0.0099 15.8 0.2 0.018 14.9 0.2 1.3 1 0 0 1 1 1 1 Syndecan domain MLANA PF14991.6 EMC77354.1 - 0.1 12.9 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein melan-A SIT PF15330.6 EMC77354.1 - 0.11 13.0 0.3 0.23 11.9 0.2 1.5 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Stevor PF17410.2 EMC77354.1 - 0.12 11.9 0.2 0.21 11.1 0.2 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame EphA2_TM PF14575.6 EMC77354.1 - 0.13 13.2 0.0 0.27 12.1 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Insulin_TMD PF17870.1 EMC77354.1 - 0.15 12.2 1.2 0.27 11.3 1.2 1.3 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment RIFIN PF02009.16 EMC77354.1 - 0.17 11.7 0.0 0.31 10.9 0.0 1.3 1 0 0 1 1 1 0 Rifin DUF3951 PF13131.6 EMC77354.1 - 0.23 11.7 2.5 0.56 10.4 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3951) DUF5385 PF17359.2 EMC77354.1 - 0.28 10.7 0.3 0.4 10.2 0.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5385) DUF2207 PF09972.9 EMC77354.1 - 0.34 9.6 0.0 0.46 9.2 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SKG6 PF08693.10 EMC77354.1 - 0.57 9.6 4.4 1 8.8 4.4 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Endonuclease_NS PF01223.23 EMC77356.1 - 9.7e-31 107.3 2.1 1.9e-30 106.3 2.1 1.5 1 1 0 1 1 1 1 DNA/RNA non-specific endonuclease Endonuclea_NS_2 PF13930.6 EMC77356.1 - 0.016 15.3 1.4 0.033 14.3 1.4 1.6 1 1 0 1 1 1 0 DNA/RNA non-specific endonuclease Sushi PF00084.20 EMC77358.1 - 1.2e-15 57.8 8.6 1.4e-08 35.2 0.9 2.3 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) G-patch PF01585.23 EMC77359.1 - 3.3e-13 49.3 1.5 7.6e-13 48.1 1.5 1.7 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 EMC77359.1 - 5.3e-05 23.0 0.1 0.0001 22.0 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nucleo_P87 PF07267.11 EMC77359.1 - 3.1 6.5 5.6 4.1 6.1 5.6 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CDC45 PF02724.14 EMC77359.1 - 7.2 4.8 6.5 11 4.2 6.5 1.2 1 0 0 1 1 1 0 CDC45-like protein 6PF2K PF01591.18 EMC77360.1 - 2.3e-104 347.6 0.1 3.6e-104 346.9 0.1 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EMC77360.1 - 2.8e-42 144.6 0.0 4.1e-42 144.1 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EMC77360.1 - 5.8e-07 29.8 0.0 1.4e-06 28.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EMC77360.1 - 0.0017 17.9 0.0 0.0029 17.1 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Zeta_toxin PF06414.12 EMC77360.1 - 0.021 14.1 0.0 0.069 12.4 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin His_Phos_2 PF00328.22 EMC77360.1 - 0.048 13.0 0.0 0.074 12.4 0.0 1.2 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) AAA_17 PF13207.6 EMC77360.1 - 0.16 12.4 0.0 0.36 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.25 EMC77361.1 - 6.7e-61 206.0 0.0 1.1e-60 205.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC77361.1 - 1.4e-41 142.5 0.4 8.6e-41 139.9 0.0 2.3 3 0 0 3 3 3 1 Protein tyrosine kinase C1_1 PF00130.22 EMC77361.1 - 3e-32 110.3 23.3 5.9e-17 61.3 7.6 3.0 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 EMC77361.1 - 3e-08 34.2 0.3 5.8e-08 33.3 0.3 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain C1_2 PF03107.16 EMC77361.1 - 1.5e-05 25.2 18.1 0.013 15.8 5.7 2.8 2 0 0 2 2 2 2 C1 domain zf-RING_9 PF13901.6 EMC77361.1 - 1.8e-05 24.8 17.3 0.0016 18.5 6.1 2.5 2 0 0 2 2 2 2 Putative zinc-RING and/or ribbon Kinase-like PF14531.6 EMC77361.1 - 0.0025 17.2 0.1 0.072 12.4 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Zf_RING PF16744.5 EMC77361.1 - 0.0051 16.9 2.5 0.0051 16.9 2.5 2.5 2 0 0 2 2 2 1 KIAA1045 RING finger PHD PF00628.29 EMC77361.1 - 0.011 15.6 21.2 0.069 13.1 6.6 2.9 2 0 0 2 2 2 0 PHD-finger Haspin_kinase PF12330.8 EMC77361.1 - 0.017 14.1 0.0 0.029 13.3 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain DZR PF12773.7 EMC77361.1 - 0.021 14.8 15.5 0.066 13.3 3.4 2.9 2 0 0 2 2 2 0 Double zinc ribbon APH PF01636.23 EMC77361.1 - 0.056 13.4 0.0 0.26 11.2 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family zf-RING-like PF08746.11 EMC77361.1 - 0.15 12.4 24.1 0.14 12.5 8.2 2.9 2 0 0 2 2 2 0 RING-like domain PHD_2 PF13831.6 EMC77361.1 - 0.54 9.9 11.4 1.3 8.6 1.9 3.0 2 0 0 2 2 2 0 PHD-finger DUF2318 PF10080.9 EMC77361.1 - 2 8.6 12.0 0.43 10.7 1.7 2.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) zf-ACC PF17848.1 EMC77361.1 - 6.5 6.9 8.8 53 4.0 1.8 3.6 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain zf-C2H2 PF00096.26 EMC77362.1 - 5.9e-19 67.4 35.6 0.0001 22.5 0.5 6.1 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC77362.1 - 6.6e-12 45.3 44.8 5.3e-07 29.8 1.4 7.2 8 1 0 8 8 8 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC77362.1 - 2.4e-09 37.3 27.6 0.0016 19.1 0.3 6.0 5 0 0 5 5 5 4 C2H2-type zinc finger FOXP-CC PF16159.5 EMC77362.1 - 1.1e-08 35.5 20.4 0.0092 16.6 0.1 4.9 1 1 2 4 4 4 3 FOXP coiled-coil domain zf-C2H2_aberr PF17017.5 EMC77362.1 - 0.11 12.7 16.1 5.9 7.0 0.2 3.4 2 1 1 3 3 3 0 Aberrant zinc-finger CHORD PF04968.12 EMC77362.1 - 0.14 12.9 23.8 3.1 8.6 4.7 4.3 2 1 2 4 4 4 0 CHORD zf-C2H2_jaz PF12171.8 EMC77362.1 - 0.22 11.8 15.6 7.8 6.9 1.5 4.9 4 1 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 EMC77362.1 - 0.76 9.6 0.0 0.76 9.6 0.0 4.3 4 0 0 4 4 4 0 C2H2-type zinc-finger domain PcF PF09461.10 EMC77362.1 - 1.1 9.7 8.9 14 6.2 0.4 4.0 3 1 1 4 4 4 0 Phytotoxin PcF protein zf_ZIC PF18366.1 EMC77362.1 - 7.8 6.7 17.6 0.48 10.6 0.6 4.7 3 1 2 5 5 5 0 Zic proteins zinc finger domain TGF_beta PF00019.20 EMC77363.1 - 1.7e-31 109.3 0.5 1.9e-31 109.1 0.5 1.0 1 0 0 1 1 1 1 Transforming growth factor beta like domain SH3_1 PF00018.28 EMC77364.1 - 3.1e-14 52.3 0.7 2.9e-13 49.2 0.3 2.4 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EMC77364.1 - 4e-14 52.2 0.4 1.2e-10 41.1 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 EMC77364.1 - 9.6e-14 50.8 1.7 2.9e-06 26.8 0.4 2.4 2 0 0 2 2 2 2 Variant SH3 domain C1_1 PF00130.22 EMC77364.1 - 7.7e-10 38.5 10.1 1.3e-09 37.7 10.1 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) STAC2_u1 PF16664.5 EMC77364.1 - 3.6e-08 33.9 1.7 5.1e-08 33.4 0.1 1.9 2 0 0 2 2 2 1 Unstructured on SH3 and cysteine-rich domain-containing protein 2 C1_2 PF03107.16 EMC77364.1 - 0.016 15.5 6.0 0.032 14.6 6.0 1.5 1 0 0 1 1 1 0 C1 domain DUF2969 PF11184.8 EMC77364.1 - 0.073 13.5 0.8 0.15 12.5 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2969) zf-RING-like PF08746.11 EMC77364.1 - 0.15 12.4 7.0 0.31 11.4 7.0 1.6 1 1 0 1 1 1 0 RING-like domain PHD PF00628.29 EMC77364.1 - 0.39 10.6 8.3 0.86 9.6 8.3 1.6 1 0 0 1 1 1 0 PHD-finger B12D PF06522.11 EMC77365.1 - 1.3e-28 98.5 0.0 1.5e-28 98.4 0.0 1.0 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit SHMT PF00464.19 EMC77366.1 - 1.2e-83 281.0 0.0 1.4e-83 280.8 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Collagen PF01391.18 EMC77367.1 - 1.1e-14 53.9 37.7 4.9e-08 32.6 18.5 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) NCD1 PF04904.13 EMC77368.1 - 2.2e-42 142.9 0.0 2.9e-42 142.5 0.0 1.1 1 0 0 1 1 1 1 NAB conserved region 1 (NCD1) DUF3720 PF12517.8 EMC77368.1 - 7.8 7.5 7.5 30 5.6 7.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3720) BTB PF00651.31 EMC77369.1 - 1.3e-23 83.3 0.1 2.6e-23 82.3 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 EMC77369.1 - 3.6e-13 49.3 49.6 2.9e-07 30.6 5.2 9.4 11 0 0 11 11 11 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC77369.1 - 1.2e-06 28.8 73.9 0.19 12.6 2.9 10.3 10 0 0 10 10 10 7 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC77369.1 - 1.6e-06 28.3 76.7 0.0027 18.1 3.6 9.7 10 0 0 10 10 10 6 Zinc finger, C2H2 type zf-C2H2_3rep PF18868.1 EMC77369.1 - 0.0026 18.4 3.7 0.0026 18.4 3.7 4.7 2 2 1 4 4 4 3 Zinc finger C2H2-type, 3 repeats BolA PF01722.18 EMC77369.1 - 0.1 12.9 4.4 12 6.3 0.1 3.8 3 1 1 4 4 4 0 BolA-like protein Zn-ribbon_8 PF09723.10 EMC77369.1 - 0.55 10.4 29.2 2.1 8.6 2.3 7.3 7 0 0 7 7 7 0 Zinc ribbon domain zinc_ribbon_15 PF17032.5 EMC77369.1 - 1.4 9.7 23.4 20 6.1 2.4 5.4 1 1 5 6 6 6 0 zinc-ribbon family Elf1 PF05129.13 EMC77369.1 - 9.2 6.4 32.8 0.23 11.5 1.4 6.0 3 3 3 6 6 6 0 Transcription elongation factor Elf1 like 7tm_1 PF00001.21 EMC77370.1 - 3.2e-36 125.0 29.3 8.9e-36 123.5 29.3 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) NAC PF01849.18 EMC77371.1 - 2.4e-25 88.3 1.0 9.9e-25 86.3 0.2 2.2 2 0 0 2 2 2 1 NAC domain RNA_pol_Rpo13 PF12136.8 EMC77371.1 - 0.043 13.7 3.9 0.097 12.6 3.9 1.6 1 0 0 1 1 1 0 RNA polymerase Rpo13 subunit HTH domain CS PF04969.16 EMC77372.1 - 4.1e-08 34.1 0.2 5.8e-08 33.6 0.2 1.2 1 0 0 1 1 1 1 CS domain Pkinase_C PF00433.24 EMC77372.1 - 0.039 14.7 2.8 0.14 12.9 2.9 1.9 2 0 0 2 2 2 0 Protein kinase C terminal domain ATP-synt_ab PF00006.25 EMC77373.1 - 7.6e-23 81.3 0.2 1e-22 80.9 0.2 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain T3SS_ATPase_C PF18269.1 EMC77373.1 - 0.0051 16.6 0.2 0.076 12.9 0.2 2.3 1 1 0 1 1 1 1 T3SS EscN ATPase C-terminal domain SKA1 PF07160.12 EMC77374.1 - 1.8e-82 276.8 10.2 2e-82 276.6 10.2 1.0 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 1 CREPT PF16566.5 EMC77374.1 - 0.0045 17.2 2.3 0.011 15.9 2.3 1.6 1 0 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour SlyX PF04102.12 EMC77374.1 - 0.0083 16.7 5.2 0.041 14.5 3.6 2.5 2 0 0 2 2 2 1 SlyX DUF3161 PF11362.8 EMC77374.1 - 0.012 15.6 0.0 0.039 13.9 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3161) ADIP PF11559.8 EMC77374.1 - 0.017 15.2 6.1 0.035 14.2 6.1 1.5 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding OmpH PF03938.14 EMC77374.1 - 0.055 13.8 3.9 0.096 13.0 1.0 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Rsc14 PF08586.10 EMC77374.1 - 0.11 13.3 0.8 0.86 10.4 0.0 2.3 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit FUSC PF04632.12 EMC77374.1 - 0.14 10.7 0.4 0.21 10.1 0.4 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family RGS PF00615.19 EMC77374.1 - 0.46 10.8 3.6 3.7 7.9 0.1 2.3 2 0 0 2 2 2 0 Regulator of G protein signaling domain Tetraspanin PF00335.20 EMC77375.1 - 5.3e-34 117.9 3.1 5.8e-34 117.8 3.1 1.0 1 0 0 1 1 1 1 Tetraspanin family SUR7 PF06687.12 EMC77375.1 - 0.00016 21.4 2.1 0.00026 20.7 2.1 1.3 1 0 0 1 1 1 1 SUR7/PalI family OPT PF03169.15 EMC77375.1 - 0.00052 18.8 2.8 0.00068 18.4 2.8 1.1 1 0 0 1 1 1 1 OPT oligopeptide transporter protein CTP_transf_1 PF01148.20 EMC77375.1 - 0.023 14.5 2.5 0.03 14.1 2.5 1.1 1 0 0 1 1 1 0 Cytidylyltransferase family DUF2207 PF09972.9 EMC77375.1 - 0.14 10.8 0.9 0.18 10.6 0.9 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Pilin_N PF07790.11 EMC77375.1 - 0.2 12.6 0.0 0.2 12.6 0.0 2.3 2 0 0 2 2 2 0 Archaeal Type IV pilin, N-terminal Phage_holin_3_6 PF07332.11 EMC77375.1 - 0.24 11.5 2.8 0.35 10.9 2.8 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4307 PF14155.6 EMC77375.1 - 0.62 9.9 7.2 3.5 7.5 0.3 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4307) DUF2371 PF10177.9 EMC77375.1 - 0.65 10.2 0.0 0.65 10.2 0.0 2.0 1 1 1 2 2 2 0 Uncharacterised conserved protein (DUF2371) VWC PF00093.18 EMC77376.1 - 9.6e-05 22.6 30.7 0.0011 19.3 0.8 3.6 3 0 0 3 3 3 3 von Willebrand factor type C domain Hist_deacetyl PF00850.19 EMC77377.1 - 4.7e-52 177.4 0.0 6.2e-52 177.0 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Phage_head_chap PF11113.8 EMC77377.1 - 0.13 12.4 0.6 0.37 10.9 0.6 1.8 1 1 0 1 1 1 0 Head assembly gene product Big_2 PF02368.18 EMC77378.1 - 0.0065 16.3 0.2 0.0065 16.3 0.2 3.7 4 0 0 4 4 4 1 Bacterial Ig-like domain (group 2) CHU_C PF13585.6 EMC77378.1 - 0.11 12.6 0.7 0.57 10.3 0.1 2.3 2 0 0 2 2 2 0 C-terminal domain of CHU protein family Big_2 PF02368.18 EMC77379.1 - 2.3e-12 46.6 0.0 2.3e-12 46.6 0.0 4.3 5 0 0 5 5 5 1 Bacterial Ig-like domain (group 2) PQQ PF01011.21 EMC77379.1 - 0.079 12.9 0.1 0.22 11.5 0.1 1.7 1 0 0 1 1 1 0 PQQ enzyme repeat T2SS-T3SS_pil_N PF13629.6 EMC77379.1 - 0.31 10.8 10.0 2.7 7.8 0.0 5.0 5 1 0 5 5 5 0 Pilus formation protein N terminal region IQ_SEC7_PH PF16453.5 EMC77380.1 - 2.3e-67 225.2 2.1 4.5e-67 224.3 0.0 2.5 3 0 0 3 3 3 1 PH domain Sec7 PF01369.20 EMC77380.1 - 4.8e-63 212.1 0.1 1e-62 211.1 0.0 1.6 2 0 0 2 2 2 1 Sec7 domain START PF01852.19 EMC77381.1 - 0.15 11.5 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 START domain CCD48 PF15799.5 EMC77382.1 - 6e-50 170.2 8.3 6.9e-50 169.9 8.3 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 48 LRRNT PF01462.18 EMC77383.1 - 1.2e-07 31.2 6.1 1.2e-07 31.2 6.1 2.4 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRRCT PF01463.24 EMC77383.1 - 0.00015 22.0 1.1 0.00039 20.8 0.2 2.3 2 0 0 2 2 2 1 Leucine rich repeat C-terminal domain LRR_8 PF13855.6 EMC77383.1 - 0.00025 20.7 0.0 0.00053 19.7 0.0 1.5 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 EMC77383.1 - 0.0062 16.9 0.1 0.047 14.1 0.0 2.3 2 1 1 3 3 3 1 Leucine Rich repeats (2 copies) Ras PF00071.22 EMC77384.1 - 2.1e-36 125.0 0.1 2.6e-36 124.7 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC77384.1 - 5.1e-18 65.4 0.0 1.1e-17 64.4 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC77384.1 - 2.2e-06 27.3 0.1 2.7e-06 27.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC77384.1 - 0.069 12.7 0.0 0.085 12.4 0.0 1.1 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Isy1 PF06246.12 EMC77385.1 - 7.1e-93 310.8 10.1 8.2e-93 310.6 10.1 1.0 1 0 0 1 1 1 1 Isy1-like splicing family BCAS3 PF12490.8 EMC77385.1 - 0.1 12.1 0.8 0.15 11.6 0.8 1.2 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 3 zf-CCHC PF00098.23 EMC77386.1 - 7.3e-53 174.4 63.9 3.6e-08 33.1 2.1 7.2 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_5 PF14787.6 EMC77386.1 - 5.7e-16 57.9 47.4 0.00043 19.9 1.7 7.1 5 1 2 7 7 7 6 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.6 EMC77386.1 - 1.1e-12 47.4 46.8 0.021 14.5 0.6 7.2 6 1 1 7 7 7 7 Zinc knuckle zf-CCHC_3 PF13917.6 EMC77386.1 - 2.4e-08 33.8 48.3 0.0027 17.7 0.3 7.1 2 1 5 7 7 7 6 Zinc knuckle zf-CCHC_2 PF13696.6 EMC77386.1 - 0.00051 19.8 58.1 0.004 16.9 1.4 7.2 7 0 0 7 7 7 5 Zinc knuckle Pkinase_Tyr PF07714.17 EMC77387.1 - 5e-57 193.1 0.0 6.8e-57 192.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC77387.1 - 2.8e-54 184.3 0.0 3.7e-54 183.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RBD PF02196.15 EMC77387.1 - 1.3e-27 95.7 0.1 2.7e-27 94.6 0.1 1.6 1 0 0 1 1 1 1 Raf-like Ras-binding domain C1_1 PF00130.22 EMC77387.1 - 2.8e-12 46.3 8.5 6e-12 45.3 8.5 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.6 EMC77387.1 - 2.4e-06 27.1 0.0 4e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like zf-RING-like PF08746.11 EMC77387.1 - 0.00032 20.9 5.6 0.00082 19.6 4.4 2.4 2 0 0 2 2 2 1 RING-like domain C1_2 PF03107.16 EMC77387.1 - 0.035 14.4 4.0 0.077 13.3 4.0 1.6 1 0 0 1 1 1 0 C1 domain Pkinase_fungal PF17667.1 EMC77387.1 - 0.043 12.6 0.6 0.095 11.5 0.6 1.7 1 1 0 1 1 1 0 Fungal protein kinase Zf_RING PF16744.5 EMC77387.1 - 0.48 10.6 3.6 2.2 8.4 3.6 2.1 1 0 0 1 1 1 0 KIAA1045 RING finger zf-C3HC4_2 PF13923.6 EMC77387.1 - 0.85 9.5 10.1 0.2 11.5 5.8 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC77387.1 - 6.2 7.3 12.5 0.48 10.8 7.2 2.0 2 0 0 2 2 2 0 Ring finger domain zf-CCCH_4 PF18044.1 EMC77388.1 - 5.4e-18 64.4 37.4 6.7e-07 29.0 4.2 5.0 5 0 0 5 5 5 4 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EMC77388.1 - 1.7e-17 62.8 34.9 8.6e-06 25.6 8.3 5.2 4 1 0 4 4 4 4 Zinc finger domain zf-CCCH PF00642.24 EMC77388.1 - 1.8e-16 59.6 30.8 4.2e-06 26.5 2.7 4.6 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EMC77388.1 - 4.6e-09 36.9 17.4 0.0067 17.1 2.3 4.4 3 1 1 4 4 4 3 Torus domain zf-CCCH_3 PF15663.5 EMC77388.1 - 1.4e-05 25.2 3.4 1.4e-05 25.2 3.4 2.9 3 0 0 3 3 3 1 Zinc-finger containing family zf-C3HC4 PF00097.25 EMC77388.1 - 6.3e-05 22.8 10.6 6.3e-05 22.8 10.6 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 PF14608.6 EMC77388.1 - 9.8e-05 22.7 28.5 0.11 13.0 1.7 4.9 4 0 0 4 4 4 3 RNA-binding, Nab2-type zinc finger zf-RING_UBOX PF13445.6 EMC77388.1 - 0.00025 21.0 6.2 0.00025 21.0 6.2 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EMC77388.1 - 0.00044 20.5 10.0 0.00044 20.5 10.0 3.9 4 1 1 5 5 4 1 Ring finger domain zf-RING_5 PF14634.6 EMC77388.1 - 0.00095 19.1 9.1 0.00095 19.1 9.1 3.0 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EMC77388.1 - 0.0048 17.0 10.1 0.0052 16.9 6.5 2.8 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EMC77388.1 - 1.5 8.7 18.3 0.49 10.3 11.3 3.7 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC77388.1 - 3.3 7.7 11.4 17 5.4 10.4 2.9 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EMC77388.1 - 5.4 7.4 19.1 0.18 12.1 9.3 3.2 3 1 0 3 3 3 0 RING-H2 zinc finger domain tRNA_int_endo_N PF02778.14 EMC77389.1 - 7.6e-19 67.2 0.6 8.1e-13 47.9 0.3 2.4 2 0 0 2 2 2 2 tRNA intron endonuclease, N-terminal domain tRNA_int_endo PF01974.17 EMC77389.1 - 1.4e-16 60.3 0.0 2.9e-16 59.3 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain PPARgamma_N PF12577.8 EMC77390.1 - 1.3e-34 118.6 1.6 3.4e-34 117.3 1.6 1.7 1 0 0 1 1 1 1 PPAR gamma N-terminal region zf-C4 PF00105.18 EMC77390.1 - 1.5e-27 95.8 15.0 2.8e-27 94.9 15.0 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 EMC77390.1 - 6.8e-17 61.7 0.5 1.9e-16 60.3 0.4 1.8 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Tmemb_55A PF09788.9 EMC77390.1 - 0.037 13.1 3.1 0.06 12.4 3.1 1.3 1 0 0 1 1 1 0 Transmembrane protein 55A Synapsin_C PF02750.14 EMC77391.1 - 4.6e-135 447.6 0.8 6.3e-135 447.1 0.8 1.2 1 0 0 1 1 1 1 Synapsin, ATP binding domain Synapsin PF02078.16 EMC77391.1 - 1e-37 128.5 0.3 6.5e-37 125.9 0.1 2.2 2 0 0 2 2 2 1 Synapsin, N-terminal domain TIMP PF00965.17 EMC77392.1 - 2.4e-58 196.9 3.2 2.9e-58 196.7 3.2 1.0 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.21 EMC77392.1 - 0.031 14.1 0.1 0.046 13.5 0.1 1.3 1 0 0 1 1 1 0 UNC-6/NTR/C345C module VGLL4 PF15245.6 EMC77393.1 - 1e-102 342.8 2.8 8.1e-102 339.9 4.5 1.6 2 0 0 2 2 2 1 Transcription cofactor vestigial-like protein 4 Vg_Tdu PF07545.14 EMC77393.1 - 6e-05 22.7 0.0 0.25 11.2 0.0 2.5 2 0 0 2 2 2 2 Vestigial/Tondu family DUF3868 PF12984.7 EMC77393.1 - 0.1 12.4 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3868) 7tm_1 PF00001.21 EMC77396.1 - 3.3e-31 108.6 11.1 4.8e-31 108.0 11.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC77396.1 - 0.00076 18.9 1.9 0.28 10.5 0.4 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx Cytochrom_B_N_2 PF13631.6 EMC77396.1 - 0.0024 17.9 0.1 0.0024 17.9 0.1 2.0 2 0 0 2 2 2 1 Cytochrome b(N-terminal)/b6/petB TctB PF07331.11 EMC77396.1 - 0.0041 17.4 5.4 0.0041 17.4 5.4 2.2 2 0 0 2 2 2 1 Tripartite tricarboxylate transporter TctB family Dicty_CAR PF05462.11 EMC77396.1 - 0.013 14.7 5.5 0.12 11.5 0.4 2.1 2 0 0 2 2 2 0 Slime mold cyclic AMP receptor Chromate_transp PF02417.15 EMC77396.1 - 0.015 15.5 5.1 0.015 15.5 5.1 2.3 1 1 0 2 2 2 0 Chromate transporter 7TM_GPCR_Srw PF10324.9 EMC77396.1 - 0.022 14.1 1.1 0.029 13.6 0.0 1.7 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srw DUF4271 PF14093.6 EMC77396.1 - 0.023 14.6 0.4 0.023 14.6 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4271) 7TM_GPCR_Srt PF10321.9 EMC77396.1 - 0.052 12.5 12.5 0.45 9.4 0.9 2.3 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srt 7TM_GPCR_Srv PF10323.9 EMC77396.1 - 0.052 12.9 6.7 0.023 14.0 1.2 2.6 3 0 0 3 3 3 0 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_1 PF00001.21 EMC77397.1 - 6.2e-42 143.7 9.3 7.4e-42 143.5 9.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 EMC77397.1 - 7.1e-08 32.1 2.3 6.5e-07 28.9 2.3 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.9 EMC77397.1 - 2.5e-07 30.3 4.1 4.1e-07 29.6 4.1 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 EMC77397.1 - 3.7e-06 26.8 6.9 3.7e-06 26.8 6.9 1.5 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx TAS2R PF05296.13 EMC77397.1 - 9.8e-06 24.9 1.1 0.0046 16.1 0.0 2.1 2 0 0 2 2 2 2 Taste receptor protein (TAS2R) 7TM_GPCR_Srsx PF10320.9 EMC77397.1 - 6.5e-05 22.4 12.0 0.00059 19.3 12.0 2.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC77397.1 - 0.00047 20.0 6.0 0.0051 16.6 6.0 2.1 1 1 0 1 1 1 1 Olfactory receptor DUF2417 PF10329.9 EMC77397.1 - 0.13 11.7 1.8 0.15 11.4 0.4 1.7 2 0 0 2 2 2 0 Region of unknown function (DUF2417) DHHC PF01529.20 EMC77397.1 - 1.2 9.3 6.6 0.26 11.4 0.4 2.3 2 0 0 2 2 2 0 DHHC palmitoyltransferase PMT_4TMC PF16192.5 EMC77397.1 - 4.7 6.8 9.9 2.9 7.4 2.5 2.4 2 0 0 2 2 2 0 C-terminal four TMM region of protein-O-mannosyltransferase MARVEL PF01284.23 EMC77400.1 - 2.4e-10 40.6 14.9 4.2e-10 39.8 14.9 1.4 1 1 0 1 1 1 1 Membrane-associating domain DUF4282 PF14110.6 EMC77400.1 - 7.3 7.4 12.0 9.3 7.1 0.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4282) Herpes_LMP1 PF05297.11 EMC77400.1 - 8.5 5.5 6.1 8.8 5.4 6.1 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) DLIC PF05783.11 EMC77401.1 - 1.8e-264 877.7 0.0 2.2e-264 877.5 0.0 1.0 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) Roc PF08477.13 EMC77401.1 - 0.00042 20.5 0.1 0.0014 18.8 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 EMC77401.1 - 0.00056 20.4 0.0 0.0011 19.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 EMC77401.1 - 0.019 14.9 0.1 0.43 10.5 0.1 2.3 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 EMC77401.1 - 0.024 15.0 0.0 0.052 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 EMC77401.1 - 0.026 14.3 0.1 0.12 12.2 0.1 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Ras PF00071.22 EMC77401.1 - 0.039 13.5 0.2 7 6.2 0.0 2.5 2 1 0 2 2 2 0 Ras family GTP_EFTU PF00009.27 EMC77401.1 - 0.11 12.0 0.3 4.1 6.9 0.0 2.4 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain DUF4461 PF14688.6 EMC77402.1 - 3e-123 411.5 0.8 3e-123 411.5 0.8 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4461) DUF4460 PF14687.6 EMC77402.1 - 1.1e-38 131.6 0.0 3.6e-38 130.0 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4460) YkyA PF10368.9 EMC77402.1 - 0.043 13.5 1.0 0.16 11.6 1.0 1.9 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein Laps PF10169.9 EMC77404.1 - 3.6e-37 127.8 20.5 3e-36 124.8 20.5 1.9 1 1 0 1 1 1 1 Learning-associated protein DUF2423 PF10338.9 EMC77404.1 - 8.9e-05 22.6 8.3 8.9e-05 22.6 8.3 2.5 3 1 0 3 3 3 1 Protein of unknown function (DUF2423) Bax1-I PF01027.20 EMC77405.1 - 2.9e-48 164.5 27.8 3.2e-48 164.3 27.8 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 BaxI_1 PF12811.7 EMC77405.1 - 0.079 12.5 20.5 0.21 11.1 20.5 1.7 1 1 0 1 1 1 0 Bax inhibitor 1 like Vma12 PF11712.8 EMC77405.1 - 3.3 7.8 9.3 2.4e+02 1.8 9.3 2.6 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase AAA_30 PF13604.6 EMC77406.1 - 6e-27 94.6 0.0 2.7e-26 92.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EMC77406.1 - 1.8e-15 57.6 0.0 1.5e-14 54.6 0.0 2.6 3 1 0 3 3 3 1 AAA domain Viral_helicase1 PF01443.18 EMC77406.1 - 4.2e-10 39.8 1.2 0.0099 15.6 0.0 3.5 2 1 1 3 3 3 3 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.6 EMC77406.1 - 1.1e-07 31.5 2.3 2.8e-07 30.3 2.3 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_11 PF13086.6 EMC77406.1 - 9.7e-05 22.3 0.9 0.041 13.7 0.0 2.6 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 EMC77406.1 - 0.00025 21.5 0.1 0.0012 19.2 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain CbiA PF01656.23 EMC77406.1 - 0.00035 20.6 0.0 0.00078 19.5 0.0 1.7 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ABC_tran PF00005.27 EMC77406.1 - 0.00036 21.1 0.0 0.0013 19.3 0.0 1.9 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 EMC77406.1 - 0.0017 18.2 0.0 0.0039 17.1 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase ParA PF10609.9 EMC77406.1 - 0.0023 17.4 0.0 0.0041 16.6 0.0 1.3 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase Rad17 PF03215.15 EMC77406.1 - 0.0063 16.5 0.1 0.42 10.5 0.0 2.8 2 1 0 2 2 2 1 Rad17 P-loop domain AAA_23 PF13476.6 EMC77406.1 - 0.0096 16.4 1.8 0.017 15.6 0.2 2.1 2 1 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EMC77406.1 - 0.016 14.4 0.0 0.044 13.0 0.0 1.7 1 0 0 1 1 1 0 NB-ARC domain AAA_14 PF13173.6 EMC77406.1 - 0.036 14.1 0.0 0.27 11.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain ArsA_ATPase PF02374.15 EMC77406.1 - 0.049 12.8 0.5 0.32 10.1 0.2 2.4 2 1 1 3 3 3 0 Anion-transporting ATPase AAA_15 PF13175.6 EMC77406.1 - 0.093 12.4 0.0 0.093 12.4 0.0 2.2 1 1 1 2 2 2 0 AAA ATPase domain DUF4888 PF16229.5 EMC77406.1 - 0.12 12.4 0.0 0.41 10.6 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4888) AAA_29 PF13555.6 EMC77406.1 - 0.13 12.1 0.1 0.41 10.4 0.0 1.9 2 0 0 2 2 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 EMC77406.1 - 0.2 12.0 0.6 1.4 9.2 0.1 2.7 3 1 0 3 3 3 0 AAA domain PDZ PF00595.24 EMC77407.1 - 2.3e-89 293.8 7.1 1.4e-13 51.0 0.0 7.3 7 0 0 7 7 7 7 PDZ domain PDZ_6 PF17820.1 EMC77407.1 - 7.6e-68 224.2 5.9 5.5e-12 45.3 0.0 7.3 7 0 0 7 7 7 7 PDZ domain PDZ_2 PF13180.6 EMC77407.1 - 1.4e-34 118.3 3.1 2.2e-05 24.7 0.0 7.5 7 0 0 7 7 7 7 PDZ domain Tricorn_PDZ PF14685.6 EMC77407.1 - 4.3e-12 45.8 1.0 0.37 10.8 0.0 6.1 6 0 0 6 6 6 4 Tricorn protease PDZ domain GRASP55_65 PF04495.14 EMC77407.1 - 0.00072 19.9 0.0 5.2 7.4 0.0 3.9 2 2 2 4 4 4 2 GRASP55/65 PDZ-like domain EutA PF06277.11 EMC77407.1 - 0.11 11.3 1.2 0.79 8.5 0.1 2.4 3 0 0 3 3 3 0 Ethanolamine utilisation protein EutA FTH PF01827.27 EMC77407.1 - 0.16 11.8 0.1 0.97 9.2 0.0 2.1 2 0 0 2 2 2 0 FTH domain TIP120 PF08623.10 EMC77408.1 - 1.4e-67 226.7 5.4 6.7e-65 218.0 0.8 4.8 3 1 2 5 5 5 1 TATA-binding protein interacting (TIP20) HEAT_EZ PF13513.6 EMC77408.1 - 5.9e-19 68.2 6.7 0.00038 20.9 0.1 11.1 9 2 3 12 12 12 3 HEAT-like repeat HEAT_2 PF13646.6 EMC77408.1 - 8e-17 61.4 0.7 0.36 11.3 0.0 8.6 6 2 2 8 8 8 4 HEAT repeats HEAT PF02985.22 EMC77408.1 - 2.9e-14 52.0 17.9 0.11 12.8 0.2 12.0 15 0 0 15 15 11 4 HEAT repeat UME PF08064.13 EMC77408.1 - 9.7e-12 44.7 6.5 0.0078 16.1 0.1 7.3 5 2 2 7 7 7 2 UME (NUC010) domain CLASP_N PF12348.8 EMC77408.1 - 3.5e-08 33.3 2.7 0.072 12.7 0.0 5.4 6 0 0 6 6 6 2 CLASP N terminal Vac14_Fab1_bd PF12755.7 EMC77408.1 - 1.6e-07 31.8 3.3 0.0082 16.7 0.1 6.6 6 2 2 8 8 7 1 Vacuolar 14 Fab1-binding region Telomere_reg-2 PF10193.9 EMC77408.1 - 1.7e-07 31.7 2.3 0.47 10.9 0.0 6.0 6 0 0 6 6 4 1 Telomere length regulation protein Adaptin_N PF01602.20 EMC77408.1 - 1.8e-07 30.1 9.6 0.00022 19.9 0.2 5.3 2 1 1 3 3 3 3 Adaptin N terminal region MMS19_C PF12460.8 EMC77408.1 - 6.4e-07 28.8 18.9 0.0002 20.6 0.6 7.0 6 2 2 8 8 8 2 RNAPII transcription regulator C-terminal RTP1_C1 PF10363.9 EMC77408.1 - 2.2e-05 24.6 5.2 1.1 9.5 0.1 7.0 7 1 1 8 8 7 1 Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 PF11865.8 EMC77408.1 - 3.6e-05 23.7 6.6 0.00072 19.5 0.1 5.5 6 2 0 6 6 6 1 Domain of unknown function (DUF3385) Cnd1 PF12717.7 EMC77408.1 - 6e-05 23.1 12.2 1.1 9.2 0.0 7.1 6 2 1 8 8 7 2 non-SMC mitotic condensation complex subunit 1 NUC173 PF08161.12 EMC77408.1 - 0.0029 17.3 1.7 13 5.3 0.0 5.4 5 2 1 6 6 5 0 NUC173 domain TAF6_C PF07571.13 EMC77408.1 - 0.007 16.7 0.1 3.4 8.0 0.0 4.4 3 1 0 3 3 3 1 TAF6 C-terminal HEAT repeat domain RRN3 PF05327.11 EMC77408.1 - 0.024 13.2 0.1 0.069 11.7 0.1 1.9 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Uso1_p115_head PF04869.14 EMC77408.1 - 0.037 13.2 0.1 0.25 10.4 0.1 2.4 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, head region API5 PF05918.11 EMC77408.1 - 0.075 11.8 1.1 6.1 5.5 0.0 4.1 6 0 0 6 6 6 0 Apoptosis inhibitory protein 5 (API5) V-ATPase_H_N PF03224.14 EMC77408.1 - 0.54 9.5 3.2 7 5.8 0.1 3.9 3 1 1 4 4 4 0 V-ATPase subunit H Pkinase PF00069.25 EMC77409.1 - 1.9e-58 197.9 0.0 2.7e-58 197.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC77409.1 - 9.5e-23 80.8 0.0 1.9e-22 79.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EMC77409.1 - 1.9e-06 28.0 0.0 0.00022 21.3 0.0 2.3 1 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EMC77409.1 - 0.0023 17.3 0.7 0.0047 16.3 0.7 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EMC77409.1 - 0.0027 17.3 2.9 0.0044 16.6 2.9 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 EMC77409.1 - 0.021 14.4 1.8 0.11 12.1 1.8 1.9 1 1 0 1 1 1 0 RIO1 family Kinase-like PF14531.6 EMC77409.1 - 0.035 13.4 0.1 0.24 10.7 0.0 1.9 1 1 0 2 2 2 0 Kinase-like WaaY PF06176.11 EMC77409.1 - 0.04 13.5 2.4 0.064 12.9 2.4 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.9 EMC77409.1 - 0.084 12.4 1.1 0.26 10.8 0.0 2.1 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL IFN-gamma PF00714.17 EMC77410.1 - 4.7e-28 97.8 0.9 5.8e-28 97.5 0.9 1.1 1 0 0 1 1 1 1 Interferon gamma API5 PF05918.11 EMC77410.1 - 0.0061 15.4 0.4 0.0079 15.1 0.4 1.1 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) Fib_alpha PF08702.10 EMC77410.1 - 0.019 15.1 4.1 0.049 13.8 1.1 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family LPP PF04728.13 EMC77410.1 - 0.18 12.2 1.9 0.38 11.2 0.1 2.3 2 1 0 2 2 2 0 Lipoprotein leucine-zipper FapA PF03961.13 EMC77410.1 - 0.82 8.2 3.1 0.98 7.9 2.8 1.2 1 1 0 1 1 1 0 Flagellar Assembly Protein A IL10 PF00726.17 EMC77411.1 - 6.3e-09 35.6 0.0 1e-08 34.9 0.0 1.4 1 1 0 1 1 1 1 Interleukin 10 IL22 PF14565.6 EMC77411.1 - 3.7e-06 27.3 0.0 4.7e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor IL22 PF14565.6 EMC77412.1 - 1.2e-73 245.9 2.7 1.4e-73 245.6 2.7 1.0 1 0 0 1 1 1 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor IL10 PF00726.17 EMC77412.1 - 6.1e-05 22.6 0.3 7e-05 22.4 0.3 1.1 1 0 0 1 1 1 1 Interleukin 10 CPL PF08144.11 EMC77412.1 - 0.0072 16.7 0.0 0.01 16.2 0.0 1.2 1 0 0 1 1 1 1 CPL (NUC119) domain MDM1 PF15501.6 EMC77413.1 - 5e-155 517.8 37.9 2.4e-154 515.5 37.9 1.9 1 1 0 1 1 1 1 Nuclear protein MDM1 KCT2 PF17818.1 EMC77413.1 - 0.07 13.2 1.4 0.23 11.5 1.4 1.9 1 0 0 1 1 1 0 Keratinocyte-associated gene product Ras PF00071.22 EMC77414.1 - 2.2e-57 193.2 0.3 2.5e-57 193.0 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC77414.1 - 7.2e-21 74.6 0.0 1.1e-20 74.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC77414.1 - 1.1e-08 34.7 0.2 1.2e-08 34.6 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC77414.1 - 7.2e-05 22.4 0.3 0.00018 21.1 0.1 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EMC77414.1 - 0.00066 19.7 0.0 0.001 19.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC77414.1 - 0.0022 17.9 2.9 0.57 10.1 0.0 2.3 1 1 0 2 2 2 2 RsgA GTPase G-alpha PF00503.20 EMC77414.1 - 0.0038 16.5 0.0 0.0059 15.8 0.0 1.3 1 1 0 1 1 1 1 G-protein alpha subunit AAA_22 PF13401.6 EMC77414.1 - 0.25 11.6 1.0 12 6.2 0.5 2.8 2 1 0 2 2 2 0 AAA domain Nup84_Nup100 PF04121.13 EMC77415.1 - 4.1e-213 709.6 20.6 4.8e-213 709.3 20.6 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 TPT PF03151.16 EMC77416.1 - 1.9e-16 60.2 11.4 2.1e-16 60.1 11.4 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EMC77416.1 - 0.00015 22.0 14.6 0.00015 22.0 14.6 2.6 2 1 0 2 2 2 1 EamA-like transporter family CopD PF05425.13 EMC77416.1 - 1.6 9.2 7.5 0.7 10.3 1.6 2.5 2 0 0 2 2 2 0 Copper resistance protein D SH3_9 PF14604.6 EMC77417.1 - 1.5e-16 60.0 0.6 3.7e-16 58.7 0.3 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EMC77417.1 - 3.4e-16 58.6 0.2 6.7e-16 57.6 0.2 1.5 1 0 0 1 1 1 1 SH3 domain FCH PF00611.23 EMC77417.1 - 4.3e-14 52.6 0.3 4.3e-14 52.6 0.3 2.7 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.17 EMC77417.1 - 5.7e-12 45.1 0.0 1.2e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 EMC77417.1 - 0.0029 17.8 0.2 0.0054 17.0 0.2 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain DUF4265 PF14085.6 EMC77417.1 - 0.7 9.9 3.8 5.5 7.0 0.1 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF4265) Presenilin PF01080.17 EMC77417.1 - 9.1 4.9 10.6 12 4.5 10.6 1.1 1 0 0 1 1 1 0 Presenilin Tetraspanin PF00335.20 EMC77418.1 - 5.9e-45 153.7 11.5 6.8e-45 153.6 11.5 1.0 1 0 0 1 1 1 1 Tetraspanin family SUR7 PF06687.12 EMC77418.1 - 0.027 14.1 7.1 0.1 12.2 2.5 2.2 2 0 0 2 2 2 0 SUR7/PalI family COX2_TM PF02790.15 EMC77418.1 - 0.038 14.1 3.6 8.6 6.6 0.1 3.2 3 0 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain DUF1616 PF07760.11 EMC77418.1 - 0.06 12.7 0.1 0.076 12.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) Hum_adeno_E3A PF05393.11 EMC77418.1 - 0.19 11.7 3.5 0.59 10.1 0.3 2.3 2 0 0 2 2 2 0 Human adenovirus early E3A glycoprotein DUF996 PF06195.13 EMC77418.1 - 0.31 11.3 8.8 0.065 13.5 4.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF996) DUF2207 PF09972.9 EMC77418.1 - 6.9 5.3 5.0 2.3 6.9 1.1 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Pkinase PF00069.25 EMC77419.1 - 5.4e-13 48.9 0.0 1.2e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC77419.1 - 1.4e-06 27.8 0.0 3.2e-06 26.6 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EMC77419.1 - 0.026 14.4 0.1 0.057 13.3 0.1 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family PTPRCAP PF15713.5 EMC77419.1 - 0.077 13.3 4.5 0.11 12.8 1.4 2.3 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated HMG_box PF00505.19 EMC77420.1 - 3.7e-19 68.9 1.4 9.7e-19 67.6 1.4 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC77420.1 - 1.2e-12 48.2 3.9 1.6e-12 47.8 0.7 2.3 1 1 1 2 2 2 1 HMG-box domain DUF4763 PF15960.5 EMC77420.1 - 0.0014 18.0 3.7 0.0028 17.0 3.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4763) Trans_reg_C PF00486.28 EMC77420.1 - 0.0035 17.4 0.3 0.63 10.2 0.0 3.1 2 1 1 3 3 3 1 Transcriptional regulatory protein, C terminal COG5 PF10392.9 EMC77420.1 - 0.088 13.0 3.9 0.083 13.1 2.3 1.7 2 0 0 2 2 2 0 Golgi transport complex subunit 5 HSD3 PF15244.6 EMC77420.1 - 0.15 11.5 7.0 0.25 10.8 7.0 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 DUF812 PF05667.11 EMC77420.1 - 0.18 10.7 11.4 0.25 10.2 11.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Lectin_N PF03954.14 EMC77420.1 - 0.67 9.7 3.8 5.7 6.7 3.9 2.2 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain DivIC PF04977.15 EMC77420.1 - 7.6 6.4 7.7 2.1 8.2 3.1 2.5 3 1 0 3 3 3 0 Septum formation initiator LRR_8 PF13855.6 EMC77422.1 - 4.6e-53 176.8 50.6 2.3e-12 46.5 1.7 6.4 1 1 4 6 6 6 6 Leucine rich repeat LRR_5 PF13306.6 EMC77422.1 - 7.7e-28 97.0 0.2 3.8e-12 46.3 0.0 3.1 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 EMC77422.1 - 1.6e-19 69.7 34.6 0.0002 21.7 2.1 7.1 5 1 1 7 7 7 7 Leucine Rich repeats (2 copies) I-set PF07679.16 EMC77422.1 - 1.6e-14 53.8 0.0 2.7e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC77422.1 - 5.2e-12 46.2 0.0 1.1e-11 45.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC77422.1 - 3e-08 33.7 0.0 5.6e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC77422.1 - 1.2e-07 32.0 0.0 2.5e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.6 EMC77422.1 - 2.9e-06 26.9 14.7 0.00047 19.7 2.7 3.6 2 2 2 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 EMC77422.1 - 5.2e-06 26.3 37.3 11 7.1 0.0 11.8 12 1 0 12 12 12 2 Leucine Rich Repeat LRRNT PF01462.18 EMC77422.1 - 0.034 13.8 8.7 0.025 14.2 2.8 3.2 4 0 0 4 4 4 0 Leucine rich repeat N-terminal domain V-set PF07686.17 EMC77422.1 - 0.19 11.9 0.0 0.88 9.8 0.0 2.1 1 1 0 1 1 1 0 Immunoglobulin V-set domain LRR_6 PF13516.6 EMC77422.1 - 0.5 10.6 36.9 6.5 7.1 0.1 10.0 11 0 0 11 11 11 0 Leucine Rich repeat BAR_3_WASP_bdg PF10456.9 EMC77424.1 - 5.9e-108 359.8 3.9 7.9e-108 359.3 3.9 1.2 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein PX PF00787.24 EMC77424.1 - 1.1e-20 73.7 4.1 3.2e-20 72.2 1.3 2.4 2 0 0 2 2 2 1 PX domain SH3_9 PF14604.6 EMC77424.1 - 5.4e-12 45.4 0.0 1.3e-11 44.2 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC77424.1 - 3.7e-10 39.3 0.0 8.9e-10 38.0 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC77424.1 - 1.1e-08 34.7 0.0 3e-08 33.2 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain Vps5 PF09325.10 EMC77424.1 - 2.2e-05 24.1 3.8 0.0026 17.3 1.4 3.1 1 1 2 3 3 3 2 Vps5 C terminal like Y_phosphatase PF00102.27 EMC77425.1 - 2.5e-80 269.5 0.0 3.4e-80 269.0 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CRAL_TRIO PF00650.20 EMC77425.1 - 7e-31 107.1 0.1 1.7e-30 105.8 0.0 1.7 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EMC77425.1 - 1e-11 45.1 0.0 2e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DSPc PF00782.20 EMC77425.1 - 0.0064 16.3 0.1 0.022 14.6 0.1 1.8 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC77425.1 - 0.0081 16.2 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EMC77425.1 - 0.16 12.1 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate Glyco_hydro_38N PF01074.22 EMC77426.1 - 2.3e-81 273.4 0.1 4.1e-81 272.5 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EMC77426.1 - 4.8e-47 160.8 0.0 7.4e-47 160.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EMC77426.1 - 4.3e-27 94.1 0.0 1.7e-26 92.2 0.0 2.0 2 0 0 2 2 2 1 Alpha mannosidase middle domain Neil1-DNA_bind PF09292.10 EMC77427.1 - 2.6e-26 91.3 1.2 1e-25 89.4 0.4 2.2 2 0 0 2 2 2 1 Endonuclease VIII-like 1, DNA bind Fapy_DNA_glyco PF01149.24 EMC77427.1 - 1e-11 45.5 0.0 1.9e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 EMC77427.1 - 2e-07 30.9 0.0 3.3e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain DUF1672 PF07901.11 EMC77427.1 - 0.16 11.3 0.1 0.21 10.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1672) COMM_domain PF07258.14 EMC77428.1 - 2.3e-17 62.9 0.1 4.4e-17 62.0 0.1 1.5 1 0 0 1 1 1 1 COMM domain DUF4817 PF16087.5 EMC77429.1 - 8.2e-15 54.4 0.5 1.9e-14 53.2 0.2 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain (DUF4817) HTH_32 PF13565.6 EMC77429.1 - 9.2e-07 29.4 1.5 1.8e-06 28.5 1.5 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_50 PF18024.1 EMC77429.1 - 0.0025 17.4 0.1 0.0048 16.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_28 PF13518.6 EMC77429.1 - 0.051 13.7 0.6 0.3 11.2 0.0 2.4 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_29 PF13551.6 EMC77429.1 - 0.11 12.5 0.1 0.35 10.9 0.1 1.8 1 0 0 1 1 1 0 Winged helix-turn helix Zona_pellucida PF00100.23 EMC77430.1 - 2e-48 165.5 0.0 2.3e-48 165.2 0.0 1.0 1 0 0 1 1 1 1 Zona pellucida-like domain LRR_6 PF13516.6 EMC77431.1 - 0.00036 20.3 3.9 1.7 8.9 0.6 3.7 3 0 0 3 3 3 2 Leucine Rich repeat LRR_4 PF12799.7 EMC77431.1 - 0.015 15.7 7.1 0.081 13.4 2.9 3.4 2 1 2 4 4 4 0 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EMC77431.1 - 0.016 15.1 0.3 0.031 14.1 0.3 1.6 1 0 0 1 1 1 0 F-box-like LRR_1 PF00560.33 EMC77431.1 - 0.094 13.3 5.6 25 5.9 0.0 4.9 4 1 0 4 4 4 0 Leucine Rich Repeat UCH PF00443.29 EMC77432.1 - 1.6e-62 211.4 0.3 2.5e-62 210.7 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMC77432.1 - 2.9e-22 79.7 4.9 2.7e-21 76.5 0.1 2.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EMC77432.1 - 3.1e-19 69.1 11.4 3.1e-19 69.1 11.4 2.9 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein zf-AD PF07776.15 EMC77432.1 - 5.9 7.2 14.2 2 8.7 3.4 3.0 2 0 0 2 2 2 0 Zinc-finger associated domain (zf-AD) Carb_anhydrase PF00194.21 EMC77433.1 - 5e-87 291.6 0.0 5.9e-87 291.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Ras PF00071.22 EMC77434.1 - 3.7e-51 172.9 0.4 4.6e-51 172.6 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC77434.1 - 4.4e-22 78.5 0.1 8.3e-22 77.7 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC77434.1 - 1.2e-11 44.4 0.4 1.4e-11 44.2 0.4 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC77434.1 - 0.00022 20.8 0.0 0.00028 20.5 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF3963 PF13124.6 EMC77434.1 - 0.018 15.0 0.8 0.034 14.1 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3963) Gtr1_RagA PF04670.12 EMC77434.1 - 0.031 13.6 0.1 0.038 13.3 0.1 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Ribosomal_S27e PF01667.17 EMC77435.1 - 1.2e-30 105.0 5.1 1.4e-30 104.7 5.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 DUF3795 PF12675.7 EMC77435.1 - 0.042 14.2 2.3 0.16 12.4 2.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3795) Beta-lactamase PF00144.24 EMC77436.1 - 1.3e-52 179.1 0.0 2.7e-28 99.2 0.0 2.0 2 0 0 2 2 2 2 Beta-lactamase Peptidase_S11 PF00768.20 EMC77436.1 - 0.022 14.2 0.0 0.04 13.3 0.0 1.4 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase DUF3552 PF12072.8 EMC77436.1 - 0.1 12.0 8.8 0.16 11.4 8.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Beta-lactamase2 PF13354.6 EMC77436.1 - 0.1 12.2 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Beta-lactamase enzyme family Tropomyosin PF00261.20 EMC77437.1 - 1.3e-96 322.6 87.9 4.9e-95 317.4 63.8 2.1 2 0 0 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.7 EMC77437.1 - 4.8e-39 133.8 87.1 1e-26 93.8 36.3 4.0 1 1 1 3 3 3 3 Tropomyosin like CLZ PF16526.5 EMC77437.1 - 2.4e-06 27.8 63.7 0.05 14.0 4.9 5.8 2 1 3 6 6 6 5 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Laminin_II PF06009.12 EMC77437.1 - 4.1e-06 26.9 49.0 6.2e-05 23.0 9.3 4.4 1 1 5 6 6 6 4 Laminin Domain II DUF4200 PF13863.6 EMC77437.1 - 0.00067 20.0 19.4 0.00067 20.0 19.4 4.5 1 1 3 4 4 4 1 Domain of unknown function (DUF4200) TMF_DNA_bd PF12329.8 EMC77437.1 - 0.001 19.0 10.1 0.001 19.0 10.1 6.7 2 2 3 6 6 6 2 TATA element modulatory factor 1 DNA binding BicD PF09730.9 EMC77437.1 - 0.0029 16.1 13.0 0.0029 16.1 13.0 2.6 1 1 2 3 3 3 1 Microtubule-associated protein Bicaudal-D CENP-F_leu_zip PF10473.9 EMC77437.1 - 0.01 15.9 78.6 0.019 15.0 34.8 2.9 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF745 PF05335.13 EMC77437.1 - 0.014 15.1 59.3 0.12 12.1 20.8 3.6 1 1 2 3 3 3 0 Protein of unknown function (DUF745) Laminin_I PF06008.14 EMC77437.1 - 0.015 15.0 63.7 0.093 12.4 12.5 4.0 1 1 3 4 4 4 0 Laminin Domain I DHR10 PF18595.1 EMC77437.1 - 0.021 14.9 14.5 0.021 14.9 14.5 5.2 1 1 4 5 5 4 0 Designed helical repeat protein 10 domain XhlA PF10779.9 EMC77437.1 - 0.024 14.8 3.7 0.024 14.8 3.7 7.7 3 2 4 7 7 7 0 Haemolysin XhlA gpW PF02831.15 EMC77437.1 - 0.07 13.0 2.2 1.4 8.9 0.0 3.5 3 1 1 4 4 4 0 gpW ADIP PF11559.8 EMC77437.1 - 0.12 12.5 60.3 0.44 10.6 7.9 4.9 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding ERM PF00769.19 EMC77437.1 - 0.38 10.5 88.2 0.15 11.9 33.4 3.3 1 1 3 4 4 4 0 Ezrin/radixin/moesin family AAA_13 PF13166.6 EMC77437.1 - 0.64 8.6 59.1 1.5 7.4 14.7 3.1 1 1 2 3 3 3 0 AAA domain DUF1794 PF08768.11 EMC77437.1 - 0.66 9.9 5.2 10 6.1 0.3 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1794) Fib_alpha PF08702.10 EMC77437.1 - 0.7 10.1 40.3 0.062 13.5 6.8 4.1 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 EMC77437.1 - 0.9 9.6 38.7 0.23 11.5 4.2 4.5 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) ATG16 PF08614.11 EMC77437.1 - 1 9.5 72.0 2.2 8.5 31.8 3.8 1 1 1 2 2 1 0 Autophagy protein 16 (ATG16) Lebercilin PF15619.6 EMC77437.1 - 1.8 8.2 77.5 7.2 6.2 29.9 3.4 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease EzrA PF06160.12 EMC77437.1 - 2.2 6.3 65.0 1 7.5 34.9 2.4 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA SNARE PF05739.19 EMC77437.1 - 2.3 8.3 12.5 2.8 8.0 0.1 4.9 5 1 1 6 6 5 0 SNARE domain MAD PF05557.13 EMC77437.1 - 3.4 5.9 71.4 2 6.7 30.3 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein DUF4472 PF14739.6 EMC77437.1 - 4.6 8.0 59.2 0.65 10.8 9.3 4.7 1 1 5 6 6 5 0 Domain of unknown function (DUF4472) T3SSipB PF16535.5 EMC77437.1 - 5.6 7.4 55.5 0.32 11.5 6.3 4.3 1 1 4 5 5 5 0 Type III cell invasion protein SipB Mce4_CUP1 PF11887.8 EMC77437.1 - 7.4 5.9 7.6 5.4 6.4 1.3 2.5 2 1 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative C2 PF00168.30 EMC77438.1 - 1.1e-06 28.8 0.0 2e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 C2 domain zf-C4 PF00105.18 EMC77439.1 - 4.2e-33 113.6 12.9 4.2e-33 113.6 12.9 2.3 3 0 0 3 3 3 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 EMC77439.1 - 3.1e-24 85.7 4.5 3.1e-24 85.7 4.5 1.9 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor Homeodomain PF00046.29 EMC77440.1 - 5.2e-22 77.4 3.9 5.2e-22 77.4 3.9 2.2 2 0 0 2 2 2 1 Homeodomain OAR PF03826.17 EMC77440.1 - 8.1e-06 25.5 1.2 2.1e-05 24.2 1.2 1.7 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.11 EMC77440.1 - 0.0092 15.9 0.1 0.027 14.3 0.1 1.8 1 0 0 1 1 1 1 Homeobox KN domain Amidase PF01425.21 EMC77441.1 - 6.2e-112 374.8 0.0 7.5e-112 374.6 0.0 1.1 1 0 0 1 1 1 1 Amidase DUF4404 PF14357.6 EMC77441.1 - 0.036 14.7 0.5 0.15 12.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) Amidase PF01425.21 EMC77442.1 - 9.9e-110 367.6 0.0 1.3e-109 367.2 0.0 1.1 1 0 0 1 1 1 1 Amidase UCR_hinge PF02320.16 EMC77443.1 - 6.1e-19 68.0 8.8 6.6e-19 67.9 8.8 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein HSCB_C PF07743.13 EMC77443.1 - 0.0048 17.4 0.4 0.0053 17.2 0.4 1.0 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain SNF2_N PF00176.23 EMC77444.1 - 8.5e-59 199.0 0.0 1.4e-58 198.3 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EMC77444.1 - 1.7e-16 60.5 0.0 3.5e-16 59.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC77444.1 - 1.4e-08 34.9 0.0 3.8e-08 33.5 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EMC77444.1 - 3.1e-07 30.3 0.0 9.3e-07 28.8 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 EMC77444.1 - 1.7e-06 27.4 0.1 9.3e-06 25.0 0.1 2.1 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Rad54_N PF08658.10 EMC77444.1 - 3.4e-06 27.4 0.1 0.00011 22.5 0.1 2.5 2 0 0 2 2 2 1 Rad54 N terminal DUF2075 PF09848.9 EMC77444.1 - 0.18 11.0 0.0 0.53 9.5 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DUF2061 PF09834.9 EMC77445.1 - 0.064 13.8 0.2 0.094 13.2 0.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2061) TPPK_C PF12555.8 EMC77445.1 - 0.082 13.0 2.7 0.14 12.2 2.7 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal LURAP PF14854.6 EMC77446.1 - 7.6e-48 161.3 2.9 9.7e-48 161.0 2.9 1.1 1 0 0 1 1 1 1 Leucine rich adaptor protein GNT-I PF03071.15 EMC77447.1 - 5.6e-50 170.4 0.2 1.3e-49 169.2 0.2 1.5 1 1 0 1 1 1 1 GNT-I family ILEI PF15711.5 EMC77447.1 - 1.2e-24 86.6 0.0 2.7e-24 85.5 0.0 1.7 1 0 0 1 1 1 1 Interleukin-like EMT inducer MGAT2 PF05060.14 EMC77447.1 - 0.036 13.1 0.0 1 8.4 0.0 2.2 2 0 0 2 2 2 0 N-acetylglucosaminyltransferase II (MGAT2) Tetraspanin PF00335.20 EMC77448.1 - 6.1e-44 150.4 13.8 6.9e-44 150.3 13.8 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF2393 PF09624.10 EMC77448.1 - 0.079 13.0 0.2 0.079 13.0 0.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2393) DUF2160 PF09928.9 EMC77448.1 - 1 9.7 6.8 0.17 12.2 2.6 1.9 2 0 0 2 2 2 0 Predicted small integral membrane protein (DUF2160) SUR7 PF06687.12 EMC77448.1 - 1.6 8.3 17.2 0.11 12.1 11.2 1.9 1 1 1 2 2 2 0 SUR7/PalI family DUF1908 PF08926.11 EMC77449.1 - 2.2e-141 469.9 0.8 2.2e-141 469.9 0.8 2.7 2 1 0 2 2 1 1 Domain of unknown function (DUF1908) Pkinase PF00069.25 EMC77449.1 - 8.9e-63 212.1 0.0 1.7e-62 211.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC77449.1 - 3.7e-26 92.0 0.0 8.4e-26 90.8 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase PDZ_6 PF17820.1 EMC77449.1 - 1.1e-11 44.4 0.1 6.4e-11 41.9 0.0 2.3 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 EMC77449.1 - 6.8e-09 36.0 0.0 1.6e-08 34.8 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC77449.1 - 3.6e-07 30.4 0.0 9.3e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain APH PF01636.23 EMC77449.1 - 5.1e-05 23.3 0.0 0.051 13.5 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EMC77449.1 - 0.00042 19.7 0.2 0.0021 17.4 0.0 2.1 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EMC77449.1 - 0.0077 15.0 0.6 0.031 13.1 0.0 2.3 2 1 0 2 2 2 1 Fungal protein kinase Tricorn_PDZ PF14685.6 EMC77449.1 - 0.0085 16.0 0.0 0.02 14.9 0.0 1.6 1 0 0 1 1 1 1 Tricorn protease PDZ domain Haspin_kinase PF12330.8 EMC77449.1 - 0.034 13.1 0.1 0.034 13.1 0.1 2.3 3 0 0 3 3 1 0 Haspin like kinase domain RIO1 PF01163.22 EMC77449.1 - 0.039 13.5 0.0 0.039 13.5 0.0 2.0 3 0 0 3 3 3 0 RIO1 family ACTL7A_N PF16840.5 EMC77449.1 - 0.088 12.9 0.2 0.24 11.5 0.2 1.7 1 0 0 1 1 1 0 Actin-like protein 7A N-terminus DUF3429 PF11911.8 EMC77450.1 - 2.6e-35 121.8 11.6 3.4e-35 121.4 11.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) DUF3325 PF11804.8 EMC77450.1 - 0.012 15.7 1.0 0.012 15.7 1.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3325) SHNi-TPR PF10516.9 EMC77452.1 - 2.5e-13 49.2 4.8 4.4e-13 48.4 0.8 2.9 3 0 0 3 3 3 1 SHNi-TPR TPR_1 PF00515.28 EMC77452.1 - 8.4e-09 34.9 1.8 0.0056 16.5 0.1 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EMC77452.1 - 2.5e-08 33.4 11.0 0.03 14.4 0.2 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 EMC77452.1 - 2e-06 27.3 2.1 0.0001 21.9 1.0 3.6 2 1 2 4 4 4 1 TPR repeat TPR_8 PF13181.6 EMC77452.1 - 6.8e-05 22.8 8.2 0.27 11.6 0.2 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EMC77452.1 - 0.00069 19.9 13.8 0.0024 18.1 3.2 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMC77452.1 - 0.2 11.8 1.7 34 4.8 0.2 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMC77452.1 - 0.34 11.6 7.7 7.3 7.5 0.1 5.0 5 1 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC77452.1 - 8.9 6.6 11.4 9.2 6.6 2.7 3.3 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Aldo_ket_red PF00248.21 EMC77453.1 - 1.2e-54 185.6 0.1 2.1e-54 184.7 0.1 1.4 1 1 0 1 1 1 1 Aldo/keto reductase family SLH PF00395.20 EMC77453.1 - 0.0096 15.9 0.1 0.13 12.3 0.1 2.6 2 0 0 2 2 2 1 S-layer homology domain AhpC-TSA PF00578.21 EMC77454.1 - 9.6e-42 141.8 0.0 1.7e-41 141.0 0.0 1.4 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 EMC77454.1 - 3.7e-16 59.1 0.0 5.4e-16 58.6 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EMC77454.1 - 1.2e-14 53.9 0.1 2.1e-14 53.1 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Endothelin PF00322.17 EMC77454.1 - 0.2 11.3 0.7 0.4 10.3 0.7 1.5 1 0 0 1 1 1 0 Endothelin family MMACHC PF16690.5 EMC77455.1 - 2.2e-101 338.0 0.1 2.5e-101 337.8 0.1 1.0 1 0 0 1 1 1 1 Methylmalonic aciduria and homocystinuria type C family Pkinase_Tyr PF07714.17 EMC77458.1 - 4.4e-51 173.6 0.0 5.7e-51 173.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC77458.1 - 6.6e-50 169.9 0.0 1.3e-49 168.9 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EMC77458.1 - 0.00066 19.1 0.2 0.0011 18.3 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMC77458.1 - 0.0015 17.4 0.0 0.0023 16.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase CAF1 PF04857.20 EMC77459.1 - 4.9e-53 180.4 0.5 8.8e-35 120.4 0.0 2.2 1 1 1 2 2 2 2 CAF1 family ribonuclease zf-CCCH PF00642.24 EMC77459.1 - 9.8e-05 22.2 0.1 9.8e-05 22.2 0.1 2.6 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) XRCC4 PF06632.12 EMC77459.1 - 0.29 9.9 6.1 0.57 9.0 6.1 1.4 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF3306 PF11748.8 EMC77459.1 - 3.8 8.4 7.6 11 6.9 7.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3306) HhH-GPD PF00730.25 EMC77460.1 - 5.5e-22 78.3 0.0 1e-21 77.4 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NUDIX_4 PF14815.6 EMC77460.1 - 7.3e-20 71.0 0.0 1.9e-19 69.6 0.0 1.7 1 0 0 1 1 1 1 NUDIX domain HHH PF00633.23 EMC77460.1 - 6.8e-10 38.3 0.4 2.6e-09 36.5 0.1 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 EMC77460.1 - 0.036 14.4 5.1 0.036 14.4 5.1 2.3 2 0 0 2 2 2 0 Iron-sulfur binding domain of endonuclease III Glyoxalase_4 PF13669.6 EMC77461.1 - 9.6e-06 25.8 0.0 0.039 14.2 0.0 2.5 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.25 EMC77461.1 - 0.0014 18.9 0.0 0.24 11.6 0.0 2.3 1 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily SelP_N PF04592.14 EMC77462.1 - 3.5e-26 92.0 1.0 3.7e-26 92.0 1.0 1.0 1 0 0 1 1 1 1 Selenoprotein P, N terminal region SWIM PF04434.17 EMC77463.1 - 0.063 13.0 2.0 0.15 11.7 2.0 1.7 1 0 0 1 1 1 0 SWIM zinc finger URO-D PF01208.17 EMC77465.1 - 2.8e-134 447.7 0.0 3.2e-134 447.5 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) NTP_transferase PF00483.23 EMC77466.1 - 2.6e-18 66.5 0.0 4.4e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 EMC77466.1 - 6.1e-15 55.9 0.0 1e-14 55.2 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain DUF4954 PF16314.5 EMC77466.1 - 1.4e-05 23.5 4.5 4.4e-05 21.8 2.8 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4954) Hexapep PF00132.24 EMC77466.1 - 0.00077 19.1 10.5 0.078 12.7 4.7 3.6 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 EMC77466.1 - 0.001 18.1 1.2 0.001 18.1 1.2 1.8 2 0 0 2 2 2 1 L-fucokinase IspD PF01128.19 EMC77466.1 - 0.0046 16.7 0.0 0.0076 16.0 0.0 1.3 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Patched PF02460.18 EMC77467.1 - 4.6e-67 226.8 10.8 2e-44 151.9 0.0 2.1 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 EMC77467.1 - 5.2e-46 156.3 5.5 5.2e-46 156.3 5.5 2.7 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 EMC77467.1 - 0.00023 20.2 4.1 0.00023 20.2 4.1 2.4 2 0 0 2 2 2 1 MMPL family Tctex-1 PF03645.13 EMC77468.1 - 6.7e-21 74.5 0.0 7.6e-21 74.3 0.0 1.0 1 0 0 1 1 1 1 Tctex-1 family Pkinase PF00069.25 EMC77469.1 - 3.7e-67 226.5 0.0 6.4e-67 225.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain POLO_box PF00659.18 EMC77469.1 - 7.6e-37 125.3 3.0 7.1e-18 64.6 0.3 2.6 2 0 0 2 2 2 2 POLO box duplicated region Pkinase_Tyr PF07714.17 EMC77469.1 - 4.7e-33 114.6 0.0 7.4e-33 113.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC77469.1 - 1.8e-07 30.8 0.0 3.8e-07 29.7 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMC77469.1 - 3.6e-05 22.7 0.0 8.1e-05 21.6 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EMC77469.1 - 0.74 9.1 3.0 0.92 8.8 0.1 2.0 1 1 1 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family LRR_8 PF13855.6 EMC77470.1 - 7.2e-19 67.3 5.5 5e-08 32.6 0.5 3.5 3 0 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EMC77470.1 - 6.8e-12 45.4 9.3 3.2e-06 27.4 1.7 3.6 1 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC77470.1 - 0.009 16.4 20.3 1.2 9.9 0.2 5.9 4 2 1 5 5 5 3 Leucine Rich Repeat LRR_6 PF13516.6 EMC77470.1 - 0.073 13.2 9.5 35 4.8 0.1 4.9 6 0 0 6 6 6 0 Leucine Rich repeat Bestrophin PF01062.21 EMC77471.1 - 3.5e-112 374.6 3.0 4e-112 374.4 3.0 1.0 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Ribosomal_S8e PF01201.22 EMC77472.1 - 1.9e-44 151.2 0.1 2.1e-44 151.0 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e Kinesin PF00225.23 EMC77473.1 - 4.1e-94 315.2 0.1 4.1e-94 315.2 0.1 1.6 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EMC77473.1 - 8.2e-16 58.3 0.4 5.1e-15 55.7 0.1 2.5 2 0 0 2 2 2 1 Microtubule binding DUF4600 PF15372.6 EMC77473.1 - 4.4 7.8 10.0 0.091 13.2 2.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) DUF5578 PF17741.1 EMC77474.1 - 1.1e-118 395.6 1.1 1.2e-118 395.4 1.1 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5578) HEAT_2 PF13646.6 EMC77474.1 - 0.00017 21.9 0.7 0.048 14.1 0.1 3.4 1 1 1 2 2 2 1 HEAT repeats Drf_GBD PF06371.13 EMC77474.1 - 0.00059 19.4 1.6 0.0022 17.6 0.2 2.2 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain E3_UbLigase_R4 PF13764.6 EMC77474.1 - 0.003 15.8 0.0 0.0041 15.4 0.0 1.2 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase UBR4 Arm PF00514.23 EMC77474.1 - 0.02 14.9 5.6 3.9 7.7 0.0 5.5 5 1 2 7 7 7 0 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.20 EMC77474.1 - 0.036 12.6 0.4 0.082 11.5 0.1 1.7 2 1 0 2 2 2 0 Adaptin N terminal region HEAT PF02985.22 EMC77474.1 - 0.064 13.5 4.7 2.4 8.6 0.0 4.5 4 1 1 5 5 5 0 HEAT repeat Proteasom_PSMB PF10508.9 EMC77474.1 - 0.1 11.1 0.1 0.15 10.5 0.1 1.3 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit DUF829 PF05705.14 EMC77475.1 - 3.2e-61 207.3 0.1 3.5e-61 207.2 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) PPDFL PF15060.6 EMC77476.1 - 0.25 11.9 1.3 0.35 11.4 0.1 1.8 1 1 1 2 2 2 0 Differentiation and proliferation regulator RNF220 PF15926.5 EMC77477.1 - 1.6e-78 263.7 11.8 6.5e-50 170.1 1.7 3.0 2 1 1 3 3 3 2 E3 ubiquitin-protein ligase RNF220 zf-C3HC4_2 PF13923.6 EMC77477.1 - 8.1e-14 51.2 15.7 1e-13 50.9 11.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMC77477.1 - 2.3e-05 24.1 10.8 6.5e-05 22.7 7.5 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC77477.1 - 0.00035 20.5 8.0 0.00035 20.5 8.0 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 EMC77477.1 - 0.00065 20.0 14.3 0.0015 18.8 10.6 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EMC77477.1 - 0.00066 19.5 10.0 0.00066 19.5 10.0 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Endonuclease_7 PF02945.15 EMC77477.1 - 0.0017 18.2 3.8 0.02 14.8 1.7 2.5 2 0 0 2 2 2 1 Recombination endonuclease VII Pox_A_type_inc PF04508.12 EMC77477.1 - 0.016 15.0 0.4 0.057 13.3 0.4 2.0 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Prok-RING_4 PF14447.6 EMC77477.1 - 0.027 14.3 11.1 0.11 12.3 6.6 2.5 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EMC77477.1 - 0.059 13.4 14.1 0.042 13.9 8.7 2.6 2 0 0 2 2 2 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 EMC77477.1 - 0.39 10.8 6.0 0.084 12.9 2.3 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-ribbon_3 PF13248.6 EMC77477.1 - 3.2 7.3 11.2 1.9 8.0 0.2 3.3 4 0 0 4 4 4 0 zinc-ribbon domain DZR PF12773.7 EMC77477.1 - 6.9 6.8 7.6 36 4.5 5.3 3.0 2 1 0 2 2 2 0 Double zinc ribbon RNase_T PF00929.24 EMC77478.1 - 6e-42 144.0 0.0 7.2e-42 143.7 0.0 1.1 1 0 0 1 1 1 1 Exonuclease DMAP1 PF05499.12 EMC77480.1 - 9.1e-78 259.8 9.0 1.5e-77 259.1 9.0 1.4 1 0 0 1 1 1 1 DNA methyltransferase 1-associated protein 1 (DMAP1) SANT_DAMP1_like PF16282.5 EMC77480.1 - 7.9e-34 115.7 4.4 2.1e-33 114.3 4.4 1.8 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 ATP-synt_D PF01813.17 EMC77480.1 - 0.0048 16.7 3.3 0.0088 15.9 3.3 1.4 1 0 0 1 1 1 1 ATP synthase subunit D DUF2110 PF09883.9 EMC77480.1 - 0.1 12.2 0.1 0.2 11.2 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2110) FapA PF03961.13 EMC77480.1 - 4.7 5.7 8.3 4.8 5.7 5.6 1.9 1 1 0 2 2 2 0 Flagellar Assembly Protein A zf-C2H2 PF00096.26 EMC77481.1 - 1.3e-18 66.3 21.1 3.2e-06 27.3 4.1 3.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC77481.1 - 7.9e-13 48.2 13.9 2.3e-07 30.9 4.8 3.8 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC77481.1 - 5.9e-11 42.2 19.3 0.0006 20.4 3.5 3.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC77481.1 - 0.033 14.5 8.7 1.1 9.6 0.3 2.9 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC77481.1 - 0.046 14.1 10.4 0.9 10.0 0.9 2.9 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EMC77481.1 - 0.24 11.8 9.1 31 5.0 0.8 2.3 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) FOXP-CC PF16159.5 EMC77481.1 - 0.52 11.0 8.9 0.76 10.4 1.7 2.9 1 1 2 3 3 3 0 FOXP coiled-coil domain zf-C2H2_11 PF16622.5 EMC77481.1 - 1.8 8.4 17.4 7.4 6.4 0.1 3.6 3 1 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 EMC77481.1 - 4 7.6 19.2 0.21 11.7 3.2 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2HE PF16278.5 EMC77481.1 - 5.4 7.5 11.2 19 5.8 5.9 2.5 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger SNF PF00209.18 EMC77482.1 - 2.7e-192 640.1 35.6 3e-192 640.0 35.6 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family ATP-synt_C PF00137.21 EMC77483.1 - 1.2e-28 99.2 31.8 2.2e-14 53.5 11.1 2.1 2 0 0 2 2 2 2 ATP synthase subunit C PIRT PF15099.6 EMC77483.1 - 2.3 7.8 7.0 6.1 6.4 0.9 2.3 1 1 1 2 2 2 0 Phosphoinositide-interacting protein family CrgA PF06781.12 EMC77483.1 - 3.9 7.6 6.5 0.45 10.6 0.1 2.6 2 1 1 3 3 3 0 Cell division protein CrgA Diphthamide_syn PF01866.17 EMC77484.1 - 1.2e-84 284.4 0.0 1.4e-84 284.1 0.0 1.0 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Importin_rep_2 PF18786.1 EMC77485.1 - 1e-50 169.3 10.5 2.8e-26 91.1 1.1 3.0 3 0 0 3 3 3 2 Importin 13 repeat Importin_rep_3 PF18806.1 EMC77485.1 - 1.4e-36 124.4 0.0 5.1e-36 122.6 0.0 2.1 1 0 0 1 1 1 1 Importin 13 repeat Xpo1 PF08389.12 EMC77485.1 - 2.6e-28 99.0 8.5 1.3e-24 86.9 0.3 4.5 4 1 0 4 4 4 2 Exportin 1-like protein Importin_rep PF18773.1 EMC77485.1 - 2.1e-23 81.7 0.9 2.1e-23 81.7 0.9 2.2 3 0 0 3 3 3 1 Importin 13 repeat IBN_N PF03810.19 EMC77485.1 - 3.2e-09 36.6 1.1 1.4e-08 34.6 0.4 2.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain SLED PF12140.8 EMC77485.1 - 0.02 15.4 0.2 0.095 13.2 0.2 2.2 1 0 0 1 1 1 0 SLED domain TGF_beta PF00019.20 EMC77486.1 - 2.5e-15 57.3 0.8 3e-15 57.1 0.8 1.1 1 0 0 1 1 1 1 Transforming growth factor beta like domain Glyco_transf_29 PF00777.18 EMC77487.1 - 1.8e-60 204.6 0.0 2.2e-60 204.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) JmjC PF02373.22 EMC77488.1 - 6.6e-44 149.0 0.1 1.7e-43 147.6 0.1 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.6 EMC77488.1 - 7.4e-33 113.0 9.4 7.4e-33 113.0 9.4 2.9 3 0 0 3 3 2 1 PHD-zinc-finger like domain Tudor_2 PF18104.1 EMC77488.1 - 3.2e-32 109.9 5.2 1.6e-15 56.5 0.5 2.6 2 0 0 2 2 2 2 Jumonji domain-containing protein 2A Tudor domain zf-HC5HC2H PF13771.6 EMC77488.1 - 1.1e-14 54.5 5.4 1.1e-14 54.5 5.4 4.0 2 1 2 4 4 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 EMC77488.1 - 1.6e-13 49.9 8.7 1.6e-13 49.9 8.7 3.3 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 EMC77488.1 - 3.7e-06 26.7 5.5 3.7e-06 26.7 5.5 4.3 4 0 0 4 4 4 2 PHD-finger LBR_tudor PF09465.10 EMC77488.1 - 1.7e-05 24.6 1.2 0.0055 16.5 0.1 2.6 2 0 0 2 2 2 2 Lamin-B receptor of TUDOR domain DUF4537 PF15057.6 EMC77488.1 - 0.0031 17.5 0.1 0.0072 16.3 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) Tudor_3 PF18115.1 EMC77488.1 - 0.0046 16.8 0.7 3.8 7.4 0.1 3.1 2 1 1 3 3 3 2 DNA repair protein Crb2 Tudor domain Rad9_Rad53_bind PF08605.10 EMC77488.1 - 0.021 15.0 0.1 0.054 13.7 0.1 1.7 1 0 0 1 1 1 0 Fungal Rad9-like Rad53-binding 53-BP1_Tudor PF09038.10 EMC77488.1 - 0.055 13.4 0.3 2.9 7.9 0.1 2.4 1 1 1 2 2 2 0 Tumour suppressor p53-binding protein-1 Tudor Y_phosphatase PF00102.27 EMC77489.1 - 2.1e-164 544.6 0.8 1.4e-85 286.7 0.0 2.3 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 EMC77489.1 - 6.3e-111 362.9 30.6 4e-17 62.3 0.6 8.9 8 1 0 8 8 8 8 Fibronectin type III domain I-set PF07679.16 EMC77489.1 - 1.1e-43 147.2 0.0 4.8e-16 58.6 0.0 4.1 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC77489.1 - 1.5e-38 131.3 1.7 1.8e-12 47.6 0.0 5.3 5 0 0 5 5 3 3 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 EMC77489.1 - 5.5e-23 81.4 22.4 0.051 14.1 0.1 10.2 9 1 0 9 9 9 7 Purple acid Phosphatase, N-terminal domain Ig_2 PF13895.6 EMC77489.1 - 2.1e-21 76.0 0.2 1.1e-07 32.0 0.0 4.6 4 0 0 4 4 4 3 Immunoglobulin domain Interfer-bind PF09294.10 EMC77489.1 - 4.2e-15 55.9 0.2 0.077 13.3 0.0 7.4 8 0 0 8 8 7 3 Interferon-alpha/beta receptor, fibronectin type III fn3_2 PF16893.5 EMC77489.1 - 1.4e-14 54.0 1.3 0.039 14.1 0.1 8.2 8 0 0 8 8 8 3 Fibronectin type III domain ig PF00047.25 EMC77489.1 - 2.8e-14 53.0 0.0 0.0073 16.5 0.0 4.2 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 EMC77489.1 - 4.6e-09 36.4 2.1 0.19 11.9 0.0 6.5 5 2 0 5 5 5 2 Immunoglobulin V-set domain DSPc PF00782.20 EMC77489.1 - 2e-08 34.1 0.0 0.005 16.7 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC77489.1 - 4e-08 33.5 0.1 0.02 14.9 0.0 3.2 3 0 0 3 3 3 2 Tyrosine phosphatase family C2-set_2 PF08205.12 EMC77489.1 - 1.1e-06 28.6 2.9 0.14 12.2 0.0 4.7 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain Y_Y_Y PF07495.13 EMC77489.1 - 1.3e-06 28.2 0.7 0.023 14.7 0.0 3.6 3 0 0 3 3 3 2 Y_Y_Y domain PTPlike_phytase PF14566.6 EMC77489.1 - 4.9e-06 26.7 0.1 0.0077 16.4 0.0 3.2 3 0 0 3 3 2 1 Inositol hexakisphosphate Ig_5 PF16681.5 EMC77489.1 - 6.8e-05 23.2 0.0 0.1 13.0 0.0 3.8 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain DUF2369 PF10179.9 EMC77489.1 - 0.00033 21.0 0.1 19 5.7 0.0 5.9 5 1 0 6 6 6 0 Uncharacterised conserved protein (DUF2369) Ig_C17orf99 PF17736.1 EMC77489.1 - 0.00075 19.5 0.0 3.9 7.6 0.0 4.3 3 1 0 3 3 3 1 C17orf99 Ig domain DUF4998 PF16389.5 EMC77489.1 - 0.0039 16.8 1.2 21 4.6 0.0 5.2 6 1 0 6 6 5 0 Domain of unknown function fn3_4 PF16794.5 EMC77489.1 - 0.0061 16.5 5.0 2.7 8.0 0.0 5.8 7 0 0 7 7 6 1 Fibronectin-III type domain Insulin_TMD PF17870.1 EMC77489.1 - 0.028 14.5 0.3 0.063 13.4 0.3 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF3377 PF11857.8 EMC77489.1 - 0.11 12.5 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) ICAM_N PF03921.14 EMC77489.1 - 0.13 11.9 0.0 0.59 9.9 0.0 2.2 1 0 0 1 1 1 0 Intercellular adhesion molecule (ICAM), N-terminal domain DUF1410 PF07198.11 EMC77489.1 - 0.44 11.1 2.3 6.1 7.4 1.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1410) TMEM154 PF15102.6 EMC77489.1 - 7.5 6.5 6.8 0.39 10.6 0.1 2.3 3 0 0 3 3 2 0 TMEM154 protein family AP_endonuc_2 PF01261.24 EMC77490.1 - 6.8e-16 58.3 0.0 9.1e-16 57.9 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Sigma70_r4 PF04545.16 EMC77491.1 - 0.058 12.9 0.1 3.6 7.2 0.0 2.8 3 0 0 3 3 3 0 Sigma-70, region 4 Med8 PF10232.9 EMC77494.1 - 6.6e-81 271.3 0.6 7.6e-81 271.1 0.6 1.0 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 CSN4_RPN5_eIF3a PF18420.1 EMC77494.1 - 0.04 14.1 0.7 0.093 12.9 0.7 1.6 1 0 0 1 1 1 0 CSN4/RPN5/eIF3a helix turn helix domain Baculo_PEP_C PF04513.12 EMC77494.1 - 0.064 13.3 0.3 13 5.8 0.2 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus ELO PF01151.18 EMC77495.1 - 9.3e-65 218.6 22.0 1.1e-64 218.3 22.0 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Spore_YhaL PF14147.6 EMC77495.1 - 0.074 12.7 1.6 0.32 10.7 0.1 2.5 2 0 0 2 2 2 0 Sporulation protein YhaL WD40 PF00400.32 EMC77496.1 - 1.6e-24 85.7 19.2 1.4e-05 25.8 0.2 7.3 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC77496.1 - 2.8e-19 69.2 9.7 3.4e-07 30.5 0.7 5.1 3 2 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMC77496.1 - 0.0002 20.4 2.1 0.03 13.3 0.3 3.2 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Hira PF07569.11 EMC77496.1 - 0.037 13.8 0.4 0.74 9.5 0.1 2.4 1 1 0 2 2 2 0 TUP1-like enhancer of split BiPBP_C PF06832.12 EMC77496.1 - 0.15 12.1 0.2 5.6 7.1 0.0 2.8 3 0 0 3 3 3 0 Penicillin-Binding Protein C-terminus Family Nup160 PF11715.8 EMC77496.1 - 0.18 10.4 3.8 8.5 4.9 0.1 3.2 3 1 1 4 4 4 0 Nucleoporin Nup120/160 EpoR_lig-bind PF09067.10 EMC77497.1 - 2e-30 105.0 0.2 1.4e-27 96.0 0.2 2.8 3 0 0 3 3 3 2 Erythropoietin receptor, ligand binding fn3 PF00041.21 EMC77497.1 - 9.9e-11 41.8 0.2 1.6e-07 31.6 0.4 2.9 2 0 0 2 2 2 2 Fibronectin type III domain IL6Ra-bind PF09240.10 EMC77497.1 - 2.9e-10 40.4 2.2 0.00035 20.9 0.8 2.6 2 0 0 2 2 2 2 Interleukin-6 receptor alpha chain, binding Pur_ac_phosph_N PF16656.5 EMC77497.1 - 0.014 16.0 0.1 0.25 12.0 0.0 2.8 2 1 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain Tissue_fac PF01108.17 EMC77497.1 - 0.028 14.3 0.0 0.086 12.7 0.0 1.8 1 0 0 1 1 1 0 Tissue factor ObR_Ig PF18589.1 EMC77497.1 - 0.035 14.5 0.0 0.71 10.3 0.0 2.7 3 0 0 3 3 3 0 Obesity receptor immunoglobulin like domain IL2RB_N1 PF18707.1 EMC77497.1 - 0.46 11.1 2.2 0.82 10.2 0.4 2.1 2 0 0 2 2 2 0 Interleukin-2 receptor subunit beta N-terminal domain 1 LRR_8 PF13855.6 EMC77498.1 - 1.7e-36 123.8 47.9 6.6e-13 48.2 10.0 2.8 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EMC77498.1 - 7.3e-10 38.9 14.9 0.00018 21.8 1.5 3.3 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC77498.1 - 4e-06 26.6 13.2 0.61 10.8 0.0 5.3 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_9 PF14580.6 EMC77498.1 - 0.00016 21.2 0.5 0.00023 20.7 0.5 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.6 EMC77498.1 - 0.0032 17.4 16.3 1.7 8.9 0.2 4.9 5 0 0 5 5 5 3 Leucine Rich repeat LRR_5 PF13306.6 EMC77498.1 - 0.005 16.8 0.0 0.0072 16.3 0.0 1.2 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) TMEM125 PF15109.6 EMC77499.1 - 1.7e-51 173.2 8.4 1.7e-51 173.2 8.4 1.9 2 0 0 2 2 2 1 TMEM125 protein family Wzy_C PF04932.15 EMC77499.1 - 0.0053 16.4 0.2 0.0053 16.4 0.2 2.1 1 1 2 3 3 3 1 O-Antigen ligase DUF4231 PF14015.6 EMC77499.1 - 0.02 15.3 5.8 0.77 10.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) DUF4282 PF14110.6 EMC77499.1 - 0.13 13.0 0.7 0.13 13.0 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) DUF4234 PF14018.6 EMC77499.1 - 1.1 9.5 4.2 4.4 7.5 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4234) PIRT PF15099.6 EMC77499.1 - 2.6 7.6 7.8 0.54 9.8 3.9 1.9 2 1 0 2 2 2 0 Phosphoinositide-interacting protein family DUF3488 PF11992.8 EMC77499.1 - 9.4 5.1 11.2 14 4.5 11.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3488) WD40 PF00400.32 EMC77500.1 - 2.7e-12 47.0 11.1 0.012 16.4 0.0 5.9 7 0 0 7 7 7 3 WD domain, G-beta repeat AAA_13 PF13166.6 EMC77500.1 - 0.00031 19.5 28.3 0.00031 19.5 28.3 3.1 1 1 2 3 3 3 1 AAA domain CALCOCO1 PF07888.11 EMC77500.1 - 0.00069 18.6 32.4 0.00069 18.6 32.4 3.7 1 1 2 3 3 3 2 Calcium binding and coiled-coil domain (CALCOCO1) like ANAPC4_WD40 PF12894.7 EMC77500.1 - 0.0018 18.6 0.9 0.34 11.2 0.0 4.1 3 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain BST2 PF16716.5 EMC77500.1 - 0.0042 17.6 8.2 0.0042 17.6 8.2 7.4 2 2 5 8 8 8 1 Bone marrow stromal antigen 2 DUF1664 PF07889.12 EMC77500.1 - 0.01 15.9 4.3 0.01 15.9 4.3 6.2 3 2 3 6 6 6 1 Protein of unknown function (DUF1664) Asparaginase_2 PF01112.18 EMC77500.1 - 3.9 6.4 4.7 9.4 5.1 0.1 2.7 2 0 0 2 2 2 0 Asparaginase Ebp2 PF05890.12 EMC77501.1 - 6.9e-84 281.6 26.1 8e-84 281.3 26.1 1.0 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 Atg14 PF10186.9 EMC77501.1 - 0.12 11.4 11.0 0.18 10.9 11.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 HEPN_Apea PF18739.1 EMC77501.1 - 0.27 11.7 3.6 0.68 10.4 3.6 1.9 1 1 0 1 1 1 0 Apea-like HEPN GvpL_GvpF PF06386.11 EMC77501.1 - 1.3 8.9 8.6 0.5 10.3 5.4 1.9 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF O-antigen_lig PF13425.6 EMC77501.1 - 4.8 5.9 5.8 6 5.5 5.8 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein eIF3_N PF09440.10 EMC77501.1 - 8.6 6.8 11.1 9.3 6.7 9.2 2.1 1 1 1 2 2 2 0 eIF3 subunit 6 N terminal domain FAM183 PF14886.6 EMC77502.1 - 4.4e-14 53.1 0.2 4.6e-14 53.1 0.2 1.0 1 0 0 1 1 1 1 FAM183A and FAM183B related PIF1 PF05970.14 EMC77503.1 - 3.6e-46 158.0 0.8 3.7e-43 148.1 0.8 3.0 2 1 0 2 2 2 1 PIF1-like helicase AAA_30 PF13604.6 EMC77503.1 - 2.6e-08 33.8 0.0 5.6e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 EMC77503.1 - 9.5e-05 22.1 0.1 0.00027 20.7 0.1 1.8 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.14 EMC77503.1 - 0.0008 17.5 0.0 0.0011 17.0 0.0 1.1 1 0 0 1 1 1 1 Helicase AAA_19 PF13245.6 EMC77503.1 - 0.01 16.2 0.0 0.022 15.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain APOBEC4_like PF18774.1 EMC77503.1 - 0.13 12.2 0.1 0.21 11.5 0.1 1.2 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase SH3_13 PF18335.1 EMC77503.1 - 0.14 12.0 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 ATP-dependent RecD-like DNA helicase SH3 domain ENOD40 PF08247.11 EMC77503.1 - 5.8 7.1 5.4 5.5 7.2 0.2 2.9 2 0 0 2 2 2 0 ENOD40 protein SOUL PF04832.12 EMC77504.1 - 1.6e-48 165.1 0.1 1.9e-48 164.8 0.1 1.0 1 0 0 1 1 1 1 SOUL heme-binding protein DHDPS PF00701.22 EMC77505.1 - 2.3e-46 157.8 0.0 2.7e-46 157.6 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family dsrm PF00035.26 EMC77506.1 - 3.2e-24 85.4 0.3 1.2e-10 41.9 0.3 2.8 2 0 0 2 2 2 2 Double-stranded RNA binding motif Helicase_C PF00271.31 EMC77506.1 - 1.1e-15 57.9 0.0 3.5e-15 56.3 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EMC77506.1 - 1e-06 28.6 0.1 3.6e-06 26.9 0.0 1.9 2 1 0 2 2 2 1 DEAD/DEAH box helicase HA2 PF04408.23 EMC77506.1 - 1.4e-05 25.3 0.3 4.5e-05 23.7 0.0 2.1 2 0 0 2 2 2 1 Helicase associated domain (HA2) T2SSE PF00437.20 EMC77506.1 - 0.0097 15.0 0.0 0.016 14.2 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein ResIII PF04851.15 EMC77506.1 - 0.02 14.9 0.5 1 9.4 0.0 2.8 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EMC77506.1 - 0.023 15.0 0.0 0.058 13.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain Ploopntkinase2 PF18747.1 EMC77506.1 - 0.03 13.6 0.0 0.067 12.4 0.0 1.5 1 0 0 1 1 1 0 P-loop Nucleotide Kinase2 AAA_14 PF13173.6 EMC77506.1 - 0.031 14.3 0.0 0.19 11.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EMC77506.1 - 0.038 13.3 0.0 0.11 11.8 0.0 1.8 2 0 0 2 2 2 0 KaiC AAA_22 PF13401.6 EMC77506.1 - 0.09 13.1 0.0 0.25 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain Dicer_dimer PF03368.14 EMC77506.1 - 0.11 12.7 0.0 1.2 9.3 0.0 2.6 2 0 0 2 2 2 0 Dicer dimerisation domain OB_NTP_bind PF07717.16 EMC77507.1 - 4.7e-14 52.5 0.0 8.1e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Laminin_N PF00055.17 EMC77508.1 - 3.3e-74 249.4 0.0 3.3e-74 249.4 0.0 3.2 3 1 0 3 3 3 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.24 EMC77508.1 - 2.3e-73 242.1 209.6 4e-11 42.9 13.6 11.2 11 1 1 12 12 12 9 Laminin EGF domain Laminin_B PF00052.18 EMC77508.1 - 5.6e-32 110.5 0.0 9.7e-32 109.7 0.0 1.4 1 0 0 1 1 1 1 Laminin B (Domain IV) DUF2357 PF09823.9 EMC77508.1 - 0.27 10.5 0.7 0.41 9.9 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2357) YscO PF07321.12 EMC77509.1 - 0.042 13.8 5.7 0.066 13.2 3.3 2.0 2 0 0 2 2 2 0 Type III secretion protein YscO ABC_tran_Xtn PF12848.7 EMC77509.1 - 0.091 12.8 0.6 0.15 12.1 0.6 1.3 1 0 0 1 1 1 0 ABC transporter Prominin PF05478.11 EMC77509.1 - 0.31 8.9 0.3 0.29 9.0 0.3 1.1 1 0 0 1 1 1 0 Prominin CTP_transf_like PF01467.26 EMC77511.1 - 6.8e-16 58.8 0.0 3.5e-10 40.2 0.0 2.1 2 0 0 2 2 2 2 Cytidylyltransferase-like EST1_DNA_bind PF10373.9 EMC77512.1 - 6.9e-55 186.5 4.8 6.9e-55 186.5 4.8 2.3 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.9 EMC77512.1 - 4.4e-25 88.9 0.3 4.4e-25 88.9 0.3 2.4 2 0 0 2 2 2 1 Telomerase activating protein Est1 zf-AD PF07776.15 EMC77512.1 - 0.0047 17.1 0.6 0.02 15.1 0.6 2.2 1 1 0 1 1 1 1 Zinc-finger associated domain (zf-AD) TPR_2 PF07719.17 EMC77512.1 - 0.054 13.6 0.0 0.18 12.0 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.6 EMC77512.1 - 0.068 13.2 0.6 0.26 11.4 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 EMC77512.1 - 0.23 11.9 1.1 0.67 10.5 0.0 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat SH3_1 PF00018.28 EMC77513.1 - 4.3e-28 96.7 0.0 1.5e-15 56.5 0.0 2.5 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 EMC77513.1 - 1.4e-22 79.3 0.1 2e-12 46.7 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 EMC77513.1 - 1.1e-17 63.4 0.0 1.7e-11 43.6 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain TPR_1 PF00515.28 EMC77513.1 - 5.1e-17 60.9 1.3 5e-06 26.1 0.1 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EMC77513.1 - 8.8e-16 56.7 2.6 7e-05 22.6 0.2 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EMC77513.1 - 3.8e-10 39.9 1.9 2.5e-05 24.5 0.3 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMC77513.1 - 6.2e-10 38.5 0.2 0.0073 16.4 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMC77513.1 - 6e-08 32.2 0.4 0.2 11.8 0.0 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat PB1 PF00564.24 EMC77513.1 - 2.5e-07 30.6 0.0 4.9e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 PB1 domain TPR_16 PF13432.6 EMC77513.1 - 2.7e-06 27.9 1.0 0.0014 19.2 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMC77513.1 - 3.4e-05 24.2 0.9 0.98 10.2 0.1 5.1 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 EMC77513.1 - 0.00015 21.9 0.0 0.17 12.3 0.0 4.0 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EMC77513.1 - 0.0021 18.7 1.5 0.36 11.8 0.1 3.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 EMC77513.1 - 0.003 17.7 0.1 0.51 10.5 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 EMC77513.1 - 0.014 15.2 0.6 17 5.5 0.4 4.0 3 1 0 3 3 3 0 Tetratricopeptide repeat Cohesin_load PF10345.9 EMC77513.1 - 0.021 13.3 0.1 0.032 12.7 0.1 1.1 1 0 0 1 1 1 0 Cohesin loading factor TPR_11 PF13414.6 EMC77513.1 - 0.028 14.1 0.5 0.28 10.9 0.1 2.8 2 1 1 3 3 3 0 TPR repeat RBD PF02196.15 EMC77513.1 - 0.047 13.8 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Raf-like Ras-binding domain P16-Arc PF04699.14 EMC77514.1 - 4.5e-48 163.5 0.1 5e-48 163.4 0.1 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Utp12 PF04003.12 EMC77514.1 - 0.0045 17.3 0.0 0.0062 16.8 0.0 1.2 1 0 0 1 1 1 1 Dip2/Utp12 Family APOBEC4 PF18775.1 EMC77515.1 - 6e-28 96.8 1.4 7.3e-28 96.5 1.4 1.1 1 0 0 1 1 1 1 APOBEC4 NAD1 PF18778.1 EMC77515.1 - 1.1e-20 74.5 0.5 1.2e-20 74.3 0.5 1.0 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 APOBEC_N PF08210.11 EMC77515.1 - 3.7e-19 69.3 0.2 4.3e-19 69.1 0.2 1.0 1 0 0 1 1 1 1 APOBEC-like N-terminal domain SNAD4 PF18750.1 EMC77515.1 - 1.3e-14 54.3 0.5 1.7e-14 53.9 0.5 1.1 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 NAD2 PF18782.1 EMC77515.1 - 2.7e-08 34.1 0.7 3.3e-08 33.9 0.7 1.1 1 0 0 1 1 1 1 Novel AID APOBEC clade 2 APOBEC2 PF18772.1 EMC77515.1 - 9.8e-08 32.2 1.1 1.1e-07 32.1 1.1 1.1 1 0 0 1 1 1 1 APOBEC2 APOBEC1 PF18769.1 EMC77515.1 - 2.7e-07 30.8 0.2 4.3e-07 30.1 0.2 1.4 1 0 0 1 1 1 1 APOBEC1 APOBEC4_like PF18774.1 EMC77515.1 - 2e-06 27.8 0.1 2.4e-06 27.5 0.1 1.2 1 0 0 1 1 1 1 APOBEC4-like -AID/APOBEC-deaminase APOBEC3 PF18771.1 EMC77515.1 - 0.00023 21.3 0.2 0.00029 21.0 0.2 1.1 1 0 0 1 1 1 1 APOBEC3 RasGEF PF00617.19 EMC77516.1 - 6.2e-60 202.4 1.2 1.2e-59 201.5 1.2 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EMC77516.1 - 2.1e-18 66.5 0.1 1e-17 64.3 0.0 2.2 2 0 0 2 2 2 1 RasGEF N-terminal motif RA PF00788.23 EMC77516.1 - 1.7e-15 57.4 0.2 1.3e-14 54.5 0.0 2.7 3 0 0 3 3 3 1 Ras association (RalGDS/AF-6) domain Acyl-CoA_ox_N PF14749.6 EMC77516.1 - 0.0016 19.0 2.8 0.63 10.6 0.1 3.3 2 1 1 3 3 3 2 Acyl-coenzyme A oxidase N-terminal Cystatin PF00031.21 EMC77516.1 - 0.15 12.3 0.5 24 5.3 0.1 3.2 3 0 0 3 3 3 0 Cystatin domain CS PF04969.16 EMC77517.1 - 1e-15 58.5 1.3 5.9e-15 56.1 0.2 2.1 2 0 0 2 2 2 1 CS domain Siah-Interact_N PF09032.11 EMC77517.1 - 1.6e-13 50.7 3.0 1.6e-13 50.7 3.0 2.4 2 1 0 2 2 2 1 Siah interacting protein, N terminal SGS PF05002.15 EMC77517.1 - 2.7e-06 27.4 2.4 6.1e-06 26.3 2.4 1.6 1 0 0 1 1 1 1 SGS domain DUF3290 PF11694.8 EMC77517.1 - 0.054 13.5 0.3 0.1 12.6 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) Pih1_fungal_CS PF18482.1 EMC77517.1 - 0.27 11.8 5.0 0.31 11.6 0.7 2.7 2 1 1 3 3 3 0 Fungal Pih1 CS domain WD40 PF00400.32 EMC77518.1 - 1.3e-22 79.6 4.4 0.032 15.1 0.0 6.8 6 0 0 6 6 6 5 WD domain, G-beta repeat zf-C3HC4_2 PF13923.6 EMC77518.1 - 7.2e-15 54.6 7.8 1.8e-14 53.3 7.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC77518.1 - 2.2e-09 37.0 8.6 6.5e-09 35.5 8.6 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC77518.1 - 2.5e-07 30.6 4.1 9e-07 28.8 4.1 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMC77518.1 - 2.6e-07 30.5 7.4 2.6e-07 30.5 7.4 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EMC77518.1 - 5.3e-07 29.4 5.5 1.4e-06 28.1 5.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC77518.1 - 5.4e-07 29.8 7.1 5.4e-07 29.8 7.1 2.8 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 EMC77518.1 - 7.1e-06 26.1 7.5 2.6e-05 24.3 7.5 2.1 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EMC77518.1 - 9.2e-05 22.7 3.7 9.2e-05 22.7 3.7 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger domain ANAPC4_WD40 PF12894.7 EMC77518.1 - 0.00014 22.1 0.4 1.6 9.1 0.0 4.3 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EMC77518.1 - 0.0003 20.2 0.0 0.0018 17.7 0.0 2.1 1 1 1 2 2 2 1 WD40-like domain zf-RING_4 PF14570.6 EMC77518.1 - 0.0057 16.4 7.1 0.015 15.1 7.1 1.7 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 EMC77518.1 - 0.0064 16.3 5.2 0.017 15.0 5.2 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf_C2H2_10 PF18414.1 EMC77518.1 - 0.041 13.4 0.1 0.13 11.8 0.1 1.9 1 0 0 1 1 1 0 C2H2 type zinc-finger zf-RING_10 PF16685.5 EMC77518.1 - 0.05 13.7 2.2 0.17 12.1 2.2 1.9 1 0 0 1 1 1 0 zinc RING finger of MSL2 AAA_23 PF13476.6 EMC77518.1 - 7.4 7.0 6.8 16 6.0 6.8 1.5 1 0 0 1 1 1 0 AAA domain Peptidase_M43 PF05572.13 EMC77519.1 - 4e-12 46.3 0.4 1.1e-11 44.8 0.4 1.8 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Sushi PF00084.20 EMC77519.1 - 2e-08 34.7 58.9 3.1e-07 30.9 1.2 9.0 9 0 0 9 9 9 4 Sushi repeat (SCR repeat) DUF4215 PF13948.6 EMC77519.1 - 3e-05 24.4 1.7 3e-05 24.4 1.7 5.9 6 1 1 7 7 7 1 Domain of unknown function (DUF4215) Reprolysin_3 PF13582.6 EMC77519.1 - 0.0087 16.6 0.7 0.018 15.6 0.7 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 EMC77519.1 - 0.069 12.4 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Met-zincin fn3 PF00041.21 EMC77519.1 - 0.11 12.8 0.6 1.3 9.5 0.0 2.3 2 0 0 2 2 2 0 Fibronectin type III domain Reprolysin_4 PF13583.6 EMC77519.1 - 0.19 11.4 0.0 0.55 9.8 0.0 1.6 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 EMC77519.1 - 0.2 10.6 1.8 0.32 9.9 1.8 1.2 1 0 0 1 1 1 0 Peptidase M66 Annexin_like PF18411.1 EMC77520.1 - 7.5e-50 167.2 0.0 1.6e-49 166.1 0.0 1.6 1 0 0 1 1 1 1 Annexin-like domain FXa_inhibition PF14670.6 EMC77520.1 - 2.5e-10 40.5 35.4 3.1e-09 36.9 3.5 4.0 3 0 0 3 3 3 2 Coagulation Factor Xa inhibitory site ASTN_2_hairpin PF18577.1 EMC77520.1 - 0.00073 19.6 0.1 0.0018 18.4 0.1 1.7 1 0 0 1 1 1 1 Astrotactin-2 C-terminal beta-hairpin domain Tme5_EGF_like PF09064.10 EMC77520.1 - 0.0017 18.2 2.8 0.0017 18.2 2.8 3.0 3 0 0 3 3 3 1 Thrombomodulin like fifth domain, EGF-like MACPF PF01823.19 EMC77520.1 - 0.0019 18.4 0.3 0.0082 16.3 0.1 2.0 2 0 0 2 2 2 1 MAC/Perforin domain UPF0560 PF10577.9 EMC77520.1 - 0.075 11.5 0.4 0.15 10.6 0.4 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF2369 PF10179.9 EMC77520.1 - 0.13 12.7 0.0 0.36 11.2 0.0 1.8 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2369) MACPF PF01823.19 EMC77521.1 - 1.2e-05 25.5 0.0 2.3e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 MAC/Perforin domain OGG_N PF07934.12 EMC77521.1 - 0.0047 17.0 4.1 10 6.2 0.2 3.9 3 1 0 4 4 4 3 8-oxoguanine DNA glycosylase, N-terminal domain Sec16_C PF12931.7 EMC77522.1 - 8.5e-43 147.1 0.0 2.6e-42 145.5 0.0 1.7 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 EMC77522.1 - 3e-10 40.7 0.0 6.2e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region ARL17 PF15840.5 EMC77522.1 - 0.086 13.2 2.5 0.12 12.7 0.1 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor-like protein 17 RasGEF PF00617.19 EMC77523.1 - 4.6e-53 180.0 0.2 1.5e-52 178.4 0.1 1.8 1 1 1 2 2 2 1 RasGEF domain PH PF00169.29 EMC77523.1 - 1.3e-09 38.5 0.1 3.1e-09 37.3 0.1 1.7 1 0 0 1 1 1 1 PH domain CRISPR_Cas9_WED PF18061.1 EMC77523.1 - 0.012 15.7 0.1 0.023 14.8 0.1 1.4 1 0 0 1 1 1 0 CRISPR-Cas9 WED domain Fibrinogen_C PF00147.18 EMC77524.1 - 4.4e-73 245.7 10.3 5.9e-73 245.3 10.3 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain ZirS_C PF16583.5 EMC77524.1 - 0.015 14.8 0.2 0.17 11.4 0.0 2.2 2 0 0 2 2 2 0 Zinc-regulated secreted antivirulence protein C-terminal domain SlyX PF04102.12 EMC77524.1 - 1.5 9.5 5.5 6.5 7.5 0.6 2.9 1 1 1 3 3 3 0 SlyX Fam20C PF06702.12 EMC77525.1 - 9.4e-87 290.4 0.0 1.4e-86 289.9 0.0 1.2 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.6 EMC77525.1 - 0.0019 17.1 0.0 0.0034 16.3 0.0 1.4 1 0 0 1 1 1 1 FAM198 protein Torsin PF06309.11 EMC77527.1 - 6e-55 184.8 0.8 9.7e-55 184.1 0.8 1.3 1 0 0 1 1 1 1 Torsin AAA PF00004.29 EMC77527.1 - 0.00047 20.6 0.0 0.00068 20.1 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EMC77527.1 - 0.00073 19.8 0.1 0.11 12.8 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EMC77527.1 - 0.0083 16.5 0.0 0.024 15.0 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain PIF1 PF05970.14 EMC77527.1 - 0.029 13.5 0.1 0.15 11.2 0.1 1.8 1 1 0 1 1 1 0 PIF1-like helicase RNA_helicase PF00910.22 EMC77527.1 - 0.092 13.1 0.0 0.15 12.5 0.0 1.4 1 0 0 1 1 1 0 RNA helicase Pkinase_Tyr PF07714.17 EMC77528.1 - 2.4e-97 325.2 0.0 3.7e-97 324.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC77528.1 - 7.2e-47 160.0 0.0 1.3e-46 159.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain F_actin_bind PF08919.10 EMC77528.1 - 6.8e-28 97.0 0.0 1.4e-27 96.0 0.0 1.5 1 0 0 1 1 1 1 F-actin binding SH2 PF00017.24 EMC77528.1 - 2.1e-24 85.4 0.2 4.9e-24 84.2 0.2 1.7 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 EMC77528.1 - 3.5e-12 45.7 0.0 6.5e-12 44.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC77528.1 - 4.8e-07 29.5 0.0 9.9e-07 28.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC77528.1 - 5e-07 29.3 0.0 1.1e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 EMC77528.1 - 2.7e-05 24.4 0.6 9e-05 22.7 0.6 1.9 1 0 0 1 1 1 1 Bacterial SH3 domain Haspin_kinase PF12330.8 EMC77528.1 - 0.0034 16.4 0.0 0.0069 15.4 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain RGS12_us1 PF16613.5 EMC77528.1 - 0.02 15.2 3.5 0.076 13.3 3.5 2.0 1 0 0 1 1 1 0 Unstructured region of RGS12 SH3_6 PF12913.7 EMC77528.1 - 0.053 13.1 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 SH3 domain (SH3b1 type) GRP PF07172.11 EMC77528.1 - 0.056 14.1 1.2 0.17 12.6 1.2 1.8 1 0 0 1 1 1 0 Glycine rich protein family MBOAT PF03062.19 EMC77529.1 - 5.8e-52 177.2 35.0 7.9e-52 176.7 35.0 1.2 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family RETICULATA-like PF11891.8 EMC77529.1 - 0.016 15.0 0.2 0.048 13.5 0.0 1.8 2 0 0 2 2 2 0 Protein RETICULATA-related Fungal_trans_2 PF11951.8 EMC77529.1 - 0.088 11.6 0.4 0.13 11.0 0.4 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain Band_7 PF01145.25 EMC77530.1 - 1.3e-26 93.7 0.0 1.9e-26 93.1 0.0 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 EMC77530.1 - 0.0043 16.8 0.2 0.0075 16.0 0.2 1.3 1 0 0 1 1 1 1 SPFH domain-Band 7 family GatB_N PF02934.15 EMC77530.1 - 0.068 12.5 0.0 0.095 12.1 0.0 1.2 1 0 0 1 1 1 0 GatB/GatE catalytic domain Synapsin PF02078.16 EMC77530.1 - 0.07 13.4 0.1 0.19 12.0 0.0 1.5 1 1 0 1 1 1 0 Synapsin, N-terminal domain OST-HTH PF12872.7 EMC77531.1 - 3.6e-05 23.5 0.0 0.00011 21.9 0.0 1.8 2 0 0 2 2 2 1 OST-HTH/LOTUS domain TUDOR PF00567.24 EMC77532.1 - 1.1e-13 51.2 0.3 2.3e-13 50.2 0.1 1.6 2 0 0 2 2 2 1 Tudor domain FAM163 PF15069.6 EMC77533.1 - 3.2e-57 193.5 4.4 3.8e-57 193.3 4.4 1.1 1 0 0 1 1 1 1 FAM163 family DUF4006 PF13179.6 EMC77533.1 - 0.0047 16.8 0.0 0.0071 16.2 0.0 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF4006) EphA2_TM PF14575.6 EMC77533.1 - 0.02 15.8 0.0 0.025 15.5 0.0 1.3 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF3169 PF11368.8 EMC77533.1 - 0.037 13.6 0.0 0.044 13.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) MscL PF01741.18 EMC77533.1 - 0.043 14.1 0.0 0.052 13.9 0.0 1.1 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL FAM176 PF14851.6 EMC77533.1 - 0.062 13.0 0.1 0.084 12.5 0.1 1.2 1 0 0 1 1 1 0 FAM176 family DUF4576 PF15144.6 EMC77533.1 - 0.19 11.6 0.0 0.25 11.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4576) HCV_NS4a PF01006.20 EMC77533.1 - 1.7 8.5 4.2 2.4 7.9 3.2 1.8 2 0 0 2 2 2 0 Hepatitis C virus non-structural protein NS4a TSP_1 PF00090.19 EMC77534.1 - 8.8e-26 89.9 118.3 5.2e-07 29.8 12.3 9.3 8 1 0 8 8 8 7 Thrombospondin type 1 domain ADAM_spacer1 PF05986.14 EMC77534.1 - 5.9e-25 87.5 0.0 9.1e-25 86.9 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 PLAC PF08686.11 EMC77534.1 - 3.9e-10 40.3 10.3 3.9e-10 40.3 10.3 3.1 2 0 0 2 2 2 1 PLAC (protease and lacunin) domain GYR PF02756.14 EMC77534.1 - 0.23 11.2 1.8 0.58 9.9 1.8 1.7 1 0 0 1 1 1 0 GYR motif LAP1C PF05609.12 EMC77535.1 - 1.2e-100 337.8 0.3 1.3e-100 337.6 0.3 1.0 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) LAP1C PF05609.12 EMC77536.1 - 2.9e-120 402.5 0.5 3.2e-120 402.3 0.5 1.0 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) Stap_Strp_tox_C PF02876.17 EMC77536.1 - 0.01 16.2 0.0 0.025 14.9 0.0 1.8 1 0 0 1 1 1 0 Staphylococcal/Streptococcal toxin, beta-grasp domain CAP_GLY PF01302.25 EMC77537.1 - 5e-21 74.5 0.2 8.7e-21 73.7 0.2 1.4 1 0 0 1 1 1 1 CAP-Gly domain DUF4378 PF14309.6 EMC77537.1 - 3e-05 24.5 0.6 3e-05 24.5 0.6 3.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4378) QSOX_Trx1 PF18108.1 EMC77538.1 - 2.1e-43 146.9 0.0 5.8e-43 145.5 0.0 1.8 2 0 0 2 2 2 1 QSOX Trx-like domain FAD_SOX PF18371.1 EMC77538.1 - 1.2e-41 141.3 0.0 4.3e-41 139.5 0.0 1.9 2 0 0 2 2 2 1 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase Evr1_Alr PF04777.13 EMC77538.1 - 2.4e-25 88.9 0.1 9.7e-25 87.0 0.1 2.0 2 0 0 2 2 2 1 Erv1 / Alr family Thioredoxin PF00085.20 EMC77538.1 - 0.00056 19.9 0.0 0.011 15.7 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 EMC77538.1 - 0.0026 18.2 0.0 22 5.6 0.0 3.7 3 1 0 3 3 3 1 Thioredoxin-like domain Zn-ribbon_8 PF09723.10 EMC77538.1 - 0.47 10.6 3.9 11 6.3 0.2 2.6 2 0 0 2 2 2 0 Zinc ribbon domain LIM PF00412.22 EMC77539.1 - 2.4e-32 110.9 19.5 1.1e-16 60.8 2.9 2.2 2 0 0 2 2 2 2 LIM domain Homeodomain PF00046.29 EMC77539.1 - 1.7e-21 75.8 2.4 2.8e-21 75.1 2.4 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC77539.1 - 0.0001 22.1 0.0 0.00026 20.8 0.0 1.7 1 1 0 1 1 1 1 Homeobox KN domain Furin-like_2 PF15913.5 EMC77539.1 - 0.0043 17.2 7.1 0.0043 17.2 7.1 2.1 1 1 1 2 2 2 1 Furin-like repeat, cysteine-rich PHF5 PF03660.14 EMC77539.1 - 1.8 8.8 10.2 0.094 12.9 3.3 2.1 1 1 1 2 2 2 0 PHF5-like protein Ank_4 PF13637.6 EMC77540.1 - 1.8e-20 73.0 0.9 1.7e-14 53.9 0.2 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC77540.1 - 2.8e-16 59.9 0.0 4.9e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EMC77540.1 - 3e-15 55.9 0.1 8.1e-07 29.2 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EMC77540.1 - 5.6e-15 55.2 0.1 1.9e-10 40.8 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) ACBP PF00887.19 EMC77540.1 - 9.8e-15 54.5 0.0 1.7e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 Acyl CoA binding protein Ank_3 PF13606.6 EMC77540.1 - 5.5e-14 50.9 0.2 5.7e-05 23.2 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat GhoS PF11080.8 EMC77540.1 - 0.11 12.5 0.0 0.45 10.5 0.0 2.0 2 0 0 2 2 2 0 Endoribonuclease GhoS EXS PF03124.14 EMC77541.1 - 4e-107 358.4 24.6 5.4e-107 357.9 24.6 1.2 1 0 0 1 1 1 1 EXS family SPX PF03105.19 EMC77541.1 - 5.6e-21 75.9 14.4 2.1e-14 54.2 3.3 2.3 1 1 1 2 2 2 2 SPX domain PDZ PF00595.24 EMC77542.1 - 3.6e-10 40.1 0.0 6e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC77542.1 - 6.1e-06 26.0 0.2 1.2e-05 25.0 0.2 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC77542.1 - 0.0063 16.8 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Syntaxin-6_N PF09177.11 EMC77544.1 - 3e-31 107.9 6.0 3.1e-31 107.8 1.2 2.6 2 1 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.19 EMC77544.1 - 2.3e-13 49.9 1.9 2.3e-13 49.9 1.9 1.8 2 0 0 2 2 2 1 SNARE domain Prominin PF05478.11 EMC77544.1 - 0.0062 14.6 4.4 0.058 11.4 3.1 1.9 1 1 1 2 2 2 1 Prominin Use1 PF09753.9 EMC77544.1 - 0.019 14.7 3.4 0.027 14.2 3.4 1.3 1 0 0 1 1 1 0 Membrane fusion protein Use1 Pox_EPC_I2-L1 PF12575.8 EMC77544.1 - 0.049 13.9 1.1 0.14 12.4 1.1 1.8 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 FliD_C PF07195.12 EMC77544.1 - 0.049 13.0 4.0 1.8 8.0 0.1 2.4 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus APG17 PF04108.12 EMC77544.1 - 0.092 11.8 10.0 0.069 12.2 2.3 2.2 1 1 1 2 2 2 0 Autophagy protein Apg17 Ran-binding PF05508.11 EMC77544.1 - 0.41 9.6 5.1 0.18 10.8 1.0 1.9 2 0 0 2 2 2 0 RanGTP-binding protein DUF1664 PF07889.12 EMC77544.1 - 0.74 9.9 7.1 17 5.4 2.8 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) EMP24_GP25L PF01105.24 EMC77544.1 - 1.5 8.7 4.6 0.88 9.5 2.2 1.9 1 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Exonuc_VII_L PF02601.15 EMC77544.1 - 3.2 7.3 7.9 8 5.9 7.9 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit KxDL PF10241.9 EMC77544.1 - 4.6 7.6 8.3 2.5 8.4 3.0 2.8 3 1 0 3 3 3 0 Uncharacterized conserved protein zf-H2C2_2 PF13465.6 EMC77545.1 - 2.4e-37 125.7 45.3 1.5e-06 28.3 0.8 7.3 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.26 EMC77545.1 - 5.5e-29 99.0 42.1 0.00018 21.8 1.2 7.1 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC77545.1 - 3.7e-22 77.1 41.1 0.0018 19.0 0.9 7.1 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC77545.1 - 2.5e-11 43.6 20.9 0.096 13.0 0.1 7.6 7 1 0 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 EMC77545.1 - 6.8e-09 35.3 26.0 0.0035 17.1 3.4 5.9 6 0 0 6 6 6 3 zinc-finger C2H2-type zinc_ribbon_9 PF14369.6 EMC77545.1 - 2e-08 34.4 17.8 0.068 13.4 0.4 6.1 5 1 1 6 6 6 2 zinc-ribbon Zn-ribbon_8 PF09723.10 EMC77545.1 - 8.9e-07 28.9 27.8 0.01 16.0 1.8 5.1 3 1 3 6 6 5 4 Zinc ribbon domain zf-C2H2_6 PF13912.6 EMC77545.1 - 2.5e-06 27.3 42.7 0.046 13.7 0.1 7.6 7 1 0 7 7 6 4 C2H2-type zinc finger zf-Di19 PF05605.12 EMC77545.1 - 5e-06 26.7 14.9 0.00057 20.1 0.6 4.7 2 2 2 5 5 5 3 Drought induced 19 protein (Di19), zinc-binding zf_UBZ PF18439.1 EMC77545.1 - 0.00041 19.9 22.8 3.3 7.4 0.1 7.1 7 0 0 7 7 7 1 Ubiquitin-Binding Zinc Finger Zn_ribbon_SprT PF17283.2 EMC77545.1 - 0.0013 18.6 23.5 0.37 10.7 2.5 5.0 2 1 3 5 5 5 4 SprT-like zinc ribbon domain zf-C2H2_3rep PF18868.1 EMC77545.1 - 0.0046 17.6 17.6 0.14 12.8 7.5 4.8 1 1 2 3 3 3 1 Zinc finger C2H2-type, 3 repeats zf-RING_7 PF02591.15 EMC77545.1 - 0.0053 16.9 14.0 13 6.1 0.1 6.1 6 0 0 6 6 6 0 C4-type zinc ribbon domain zf-C2HE PF16278.5 EMC77545.1 - 0.0062 17.0 3.0 0.0062 17.0 3.0 5.1 1 1 4 5 5 5 1 C2HE / C2H2 / C2HC zinc-binding finger HypA PF01155.19 EMC77545.1 - 0.012 15.6 14.1 9.9 6.2 1.5 3.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Rad50_zn_hook PF04423.14 EMC77545.1 - 0.016 15.0 2.2 16 5.4 0.0 3.6 3 0 0 3 3 3 0 Rad50 zinc hook motif YacG PF03884.14 EMC77545.1 - 0.019 14.7 6.6 13 5.6 0.1 4.5 4 0 0 4 4 4 0 DNA gyrase inhibitor YacG zf-trcl PF13451.6 EMC77545.1 - 0.043 13.7 22.5 0.27 11.2 0.1 5.7 4 2 0 4 4 4 0 Probable zinc-ribbon domain FYDLN_acid PF09538.10 EMC77545.1 - 0.053 14.2 10.4 34 5.2 2.9 5.1 1 1 3 4 4 4 0 Protein of unknown function (FYDLN_acid) BolA PF01722.18 EMC77545.1 - 0.079 13.2 6.1 7.9 6.8 0.1 4.1 2 2 3 5 5 5 0 BolA-like protein C1_4 PF07975.12 EMC77545.1 - 0.094 13.0 22.8 1.6 9.1 3.4 4.9 1 1 4 5 5 5 0 TFIIH C1-like domain zinc_ribbon_15 PF17032.5 EMC77545.1 - 0.11 13.3 17.5 4.1 8.2 0.8 4.0 1 1 3 5 5 5 0 zinc-ribbon family zf-C2H2_9 PF16293.5 EMC77545.1 - 0.13 12.1 7.8 8.5 6.3 0.0 4.5 3 2 3 6 6 4 0 C2H2 type zinc-finger (1 copy) zinc-ribbons_6 PF07191.12 EMC77545.1 - 0.16 11.9 19.6 3e+02 1.5 3.0 5.0 1 1 1 2 2 2 0 zinc-ribbons FYVE PF01363.21 EMC77545.1 - 0.19 11.9 25.2 1.4 9.1 9.1 4.7 1 1 3 4 4 4 0 FYVE zinc finger DUF2225 PF09986.9 EMC77545.1 - 0.34 10.6 13.4 0.77 9.4 0.2 4.0 3 2 1 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-met PF12874.7 EMC77545.1 - 1.2 9.6 0.0 1.2 9.6 0.0 6.2 7 1 0 7 7 5 0 Zinc-finger of C2H2 type zf-ribbon_3 PF13248.6 EMC77545.1 - 1.6 8.3 25.1 2.2 7.8 0.6 5.8 6 0 0 6 6 6 0 zinc-ribbon domain Zn-C2H2_12 PF18112.1 EMC77545.1 - 2 8.9 11.5 11 6.6 0.4 4.6 4 0 0 4 4 4 0 Autophagy receptor zinc finger-C2H2 domain DUF3268 PF11672.8 EMC77545.1 - 2.8 8.3 13.6 11 6.3 0.3 3.5 1 1 2 4 4 4 0 zinc-finger-containing domain zf-FPG_IleRS PF06827.14 EMC77545.1 - 3 7.8 16.9 7.9 6.4 0.0 5.7 5 1 1 6 6 6 0 Zinc finger found in FPG and IleRS Rep_fac-A_C PF08646.10 EMC77545.1 - 3 7.6 11.3 75 3.0 4.9 4.2 1 1 3 4 4 4 0 Replication factor-A C terminal domain OrfB_Zn_ribbon PF07282.11 EMC77545.1 - 3.1 7.8 22.7 10 6.1 1.8 5.0 3 1 3 6 6 6 0 Putative transposase DNA-binding domain zf-AN1 PF01428.16 EMC77545.1 - 3.2 8.0 30.3 12 6.1 0.1 6.4 5 1 1 6 6 6 0 AN1-like Zinc finger GAGA PF09237.11 EMC77545.1 - 4.8 7.1 17.2 6.5 6.6 0.2 4.6 1 1 3 5 5 5 0 GAGA factor Acetone_carb_G PF08882.11 EMC77545.1 - 7.5 6.7 7.9 0.3 11.2 0.6 2.5 2 2 1 3 3 2 0 Acetone carboxylase gamma subunit Ribosomal_L44 PF00935.19 EMC77545.1 - 7.9 7.0 16.4 0.1 13.1 1.4 3.9 4 1 1 5 5 4 0 Ribosomal protein L44 Gln-synt_C PF00120.24 EMC77546.1 - 1.1e-17 64.1 0.0 1.5e-12 47.2 0.0 2.2 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 EMC77546.1 - 6.5e-14 51.4 0.0 1.1e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain F-box-like PF12937.7 EMC77546.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 F-box-like RGS PF00615.19 EMC77547.1 - 1e-07 32.2 0.2 0.0011 19.2 0.0 3.3 3 0 0 3 3 3 2 Regulator of G protein signaling domain Ank_2 PF12796.7 EMC77549.1 - 7.5e-43 145.0 0.2 2.4e-13 50.4 0.0 4.6 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC77549.1 - 6.1e-38 128.7 0.1 3.7e-07 30.6 0.0 7.7 3 2 5 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC77549.1 - 8.7e-34 111.7 0.0 0.00077 19.7 0.0 9.0 8 0 0 8 8 8 7 Ankyrin repeat Ank_5 PF13857.6 EMC77549.1 - 7.5e-33 112.2 0.4 1.3e-07 31.7 0.0 6.5 3 2 4 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 EMC77549.1 - 7.9e-33 111.5 0.1 3.7e-05 24.0 0.0 8.3 8 0 0 8 8 8 6 Ankyrin repeat Ribonuc_2-5A PF06479.12 EMC77549.1 - 1.7e-11 44.4 1.1 1.1e-10 41.7 0.5 2.4 2 0 0 2 2 2 1 Ribonuclease 2-5A Pkinase PF00069.25 EMC77549.1 - 1.4e-10 41.0 0.0 3.4e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EMC77549.1 - 2.1e-08 33.8 0.5 3e-07 30.0 0.0 2.3 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 EMC77549.1 - 1.5e-05 24.4 0.0 4.2e-05 23.0 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 EMC77549.1 - 0.072 12.7 0.1 0.16 11.5 0.1 1.6 1 1 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 EMC77549.1 - 0.13 12.2 0.1 0.43 10.5 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family RGS PF00615.19 EMC77550.1 - 1.2e-36 125.5 3.9 1.5e-36 125.2 3.9 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS PF00615.19 EMC77551.1 - 2.1e-38 131.2 2.3 2.4e-38 131.0 2.3 1.0 1 0 0 1 1 1 1 Regulator of G protein signaling domain Arteri_nsp7a PF16749.5 EMC77551.1 - 0.027 14.6 0.1 0.034 14.3 0.1 1.2 1 0 0 1 1 1 0 Arterivirus nonstructural protein 7 alpha MnmE_helical PF12631.7 EMC77551.1 - 0.11 12.7 0.1 0.14 12.3 0.1 1.2 1 0 0 1 1 1 0 MnmE helical domain CENP-L PF13092.6 EMC77552.1 - 2.9e-30 105.7 0.1 4e-30 105.2 0.1 1.2 1 0 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 Kelch_1 PF01344.25 EMC77553.1 - 3.1e-92 302.0 20.9 3.5e-17 61.7 0.5 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EMC77553.1 - 1.2e-53 177.7 7.3 1.9e-09 37.5 0.0 6.4 2 2 4 6 6 6 6 Kelch motif BACK PF07707.15 EMC77553.1 - 2.5e-38 130.3 0.5 4.3e-38 129.6 0.1 1.6 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_4 PF13418.6 EMC77553.1 - 1.3e-35 121.1 7.1 1.5e-05 24.9 0.0 6.2 2 2 4 6 6 6 6 Galactose oxidase, central domain BTB PF00651.31 EMC77553.1 - 9.3e-33 112.8 0.7 1.5e-32 112.1 0.3 1.6 2 0 0 2 2 1 1 BTB/POZ domain Kelch_2 PF07646.15 EMC77553.1 - 8.4e-32 107.9 6.4 1.2e-06 28.2 0.2 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 EMC77553.1 - 1.2e-30 105.1 16.2 9.4e-06 25.8 0.0 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC77553.1 - 8.1e-06 25.7 8.6 2 8.5 0.1 5.9 6 0 0 6 6 6 3 Kelch motif XPA_C PF05181.12 EMC77553.1 - 0.033 14.1 0.4 5.6 7.0 0.0 3.3 4 0 0 4 4 4 0 XPA protein C-terminus Glu_cyclase_2 PF05096.12 EMC77553.1 - 0.077 12.4 0.0 30 3.9 0.0 2.7 1 1 0 3 3 3 0 Glutamine cyclotransferase N-glycanase_C PF09113.10 EMC77553.1 - 0.11 12.3 0.0 0.27 11.0 0.0 1.6 1 0 0 1 1 1 0 Peptide-N-glycosidase F, C terminal PQQ_3 PF13570.6 EMC77553.1 - 5.1 7.7 16.7 1.1 9.9 0.5 4.8 5 0 0 5 5 5 0 PQQ-like domain DUF2452 PF10504.9 EMC77554.1 - 1.5e-57 193.4 0.1 1.7e-57 193.2 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2452) 2OG-FeII_Oxy_3 PF13640.6 EMC77555.1 - 2.6e-11 44.2 0.0 5.6e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 EMC77555.1 - 2.4e-09 37.6 0.0 4.6e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 EMC77555.1 - 0.037 14.7 0.0 0.071 13.8 0.0 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily TPR_2 PF07719.17 EMC77555.1 - 0.15 12.3 1.0 2.8 8.3 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat PMP22_Claudin PF00822.20 EMC77556.1 - 2.7e-16 59.9 2.4 3.6e-16 59.5 2.4 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC77556.1 - 2e-09 37.5 3.8 5.4e-09 36.1 3.8 1.6 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction L_HMGIC_fpl PF10242.9 EMC77556.1 - 0.0018 18.5 0.8 0.0023 18.2 0.8 1.3 1 1 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein Clc-like PF07062.12 EMC77556.1 - 0.03 13.8 0.4 0.052 13.0 0.3 1.4 1 1 0 1 1 1 0 Clc-like TMEM100 PF16311.5 EMC77556.1 - 0.064 12.8 0.2 0.12 12.0 0.2 1.4 1 0 0 1 1 1 0 Transmembrane protein 100 FAM70 PF14967.6 EMC77556.1 - 0.13 11.7 0.1 0.15 11.5 0.1 1.3 1 0 0 1 1 1 0 FAM70 protein Pro_isomerase PF00160.21 EMC77557.1 - 1.8e-48 164.8 0.0 2e-48 164.6 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DFP PF04127.15 EMC77558.1 - 1.6e-10 41.1 0.0 2.2e-10 40.7 0.0 1.2 1 1 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein TPR_12 PF13424.6 EMC77559.1 - 7.3e-06 26.2 0.7 0.0055 17.0 0.2 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMC77559.1 - 0.063 13.1 0.7 17 5.4 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Sugar_tr PF00083.24 EMC77560.1 - 2.2e-156 521.2 23.8 2.8e-156 520.9 23.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMC77560.1 - 1.3e-19 70.4 34.7 7.8e-18 64.5 28.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pox_EPC_I2-L1 PF12575.8 EMC77560.1 - 0.3 11.4 3.2 1.3 9.3 3.2 2.2 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 zf-H2C2_2 PF13465.6 EMC77562.1 - 4.2e-24 83.8 35.3 3.4e-07 30.4 2.1 5.2 5 0 0 5 5 5 5 Zinc-finger double domain zf-C2H2 PF00096.26 EMC77562.1 - 1.2e-20 72.7 38.2 3.8e-06 27.1 1.2 5.0 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC77562.1 - 1.8e-13 50.1 33.6 0.0013 19.3 2.8 4.8 5 0 0 5 5 5 4 C2H2-type zinc finger zf-Di19 PF05605.12 EMC77562.1 - 4.2e-05 23.8 5.4 4.2e-05 23.8 5.4 3.4 2 1 2 4 4 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 EMC77562.1 - 5.6e-05 23.0 29.7 0.0013 18.7 3.5 4.5 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EMC77562.1 - 0.00064 20.0 2.0 0.00064 20.0 2.0 2.9 1 1 2 3 3 3 2 C2H2-type zinc ribbon zf-C2HC_2 PF13913.6 EMC77562.1 - 0.00071 19.4 1.8 12 5.9 0.0 4.0 3 0 0 3 3 3 0 zinc-finger of a C2HC-type FOXP-CC PF16159.5 EMC77562.1 - 0.0053 17.3 11.7 0.13 12.9 1.0 3.9 1 1 2 3 3 3 1 FOXP coiled-coil domain zf-C2H2_11 PF16622.5 EMC77562.1 - 0.0094 15.7 1.9 0.0094 15.7 1.9 3.5 4 1 0 4 4 3 2 zinc-finger C2H2-type zf_C2H2_10 PF18414.1 EMC77562.1 - 0.11 12.1 0.1 0.11 12.1 0.1 3.3 4 0 0 4 4 4 0 C2H2 type zinc-finger zf-C2H2_2 PF12756.7 EMC77562.1 - 0.24 11.7 22.2 0.74 10.2 2.6 3.9 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) PyrI_C PF02748.15 EMC77562.1 - 0.32 10.9 0.1 0.32 10.9 0.1 3.6 2 1 1 3 3 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-met PF12874.7 EMC77562.1 - 0.93 10.0 29.9 0.3 11.5 3.0 4.9 5 0 0 5 5 5 0 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 EMC77562.1 - 1.3 9.3 16.6 5.7 7.1 3.4 3.5 2 1 1 3 3 3 0 Zinc ribbon domain zf-C2H2_jaz PF12171.8 EMC77562.1 - 1.7 9.1 18.9 6.4 7.2 1.3 4.4 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 EMC77562.1 - 2.5 8.6 19.3 0.36 11.3 3.3 3.1 2 1 2 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_9 PF16293.5 EMC77562.1 - 3.1 7.7 9.6 43 4.1 0.5 3.9 2 1 2 4 4 4 0 C2H2 type zinc-finger (1 copy) zinc_ribbon_15 PF17032.5 EMC77562.1 - 5.8 7.7 12.7 2.7 8.8 4.2 2.6 1 1 1 2 2 2 0 zinc-ribbon family Trypsin PF00089.26 EMC77563.1 - 2.8e-45 154.8 0.0 3.1e-45 154.7 0.0 1.0 1 0 0 1 1 1 1 Trypsin Tcell_CD4_C PF12104.8 EMC77564.1 - 4 7.4 9.8 19 5.3 1.5 3.1 2 0 0 2 2 2 0 T cell CD4 receptor C terminal region UCH PF00443.29 EMC77565.1 - 2.1e-33 115.9 0.4 7e-33 114.2 0.0 2.1 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMC77565.1 - 1.4e-20 74.1 4.9 1.6e-18 67.4 0.0 3.6 4 0 0 4 4 4 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 EMC77565.1 - 4.8e-10 39.9 0.2 2.2e-06 28.2 0.0 3.8 3 1 0 3 3 3 2 DUSP domain ubiquitin PF00240.23 EMC77565.1 - 0.00013 21.7 0.0 0.00036 20.2 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family Collagen PF01391.18 EMC77566.1 - 0.024 14.4 4.7 0.1 12.4 4.7 2.0 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) Peptidase_M13_N PF05649.13 EMC77567.1 - 1.1e-125 420.3 1.1 1.4e-125 420.0 1.1 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 EMC77567.1 - 5.5e-74 248.2 0.0 1.8e-73 246.5 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M13 DUF3135 PF11333.8 EMC77567.1 - 0.13 12.6 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3135) ImmE5 PF11480.8 EMC77567.1 - 0.14 12.6 0.1 0.37 11.3 0.1 1.7 1 0 0 1 1 1 0 Colicin-E5 Imm protein Linker_histone PF00538.19 EMC77568.1 - 3e-54 181.3 0.2 2.4e-18 66.3 0.0 3.4 3 0 0 3 3 3 3 linker histone H1 and H5 family YL1 PF05764.13 EMC77568.1 - 0.00026 21.2 15.2 0.00026 21.2 15.2 2.6 2 1 0 2 2 2 1 YL1 nuclear protein SDA1 PF05285.12 EMC77568.1 - 0.0087 15.5 40.1 0.0097 15.4 6.5 2.5 2 1 0 2 2 2 2 SDA1 Nop14 PF04147.12 EMC77568.1 - 0.12 10.6 30.7 0.17 10.1 9.3 2.2 2 0 0 2 2 2 0 Nop14-like family CDC45 PF02724.14 EMC77568.1 - 0.29 9.4 29.1 0.17 10.2 11.8 2.3 2 0 0 2 2 2 0 CDC45-like protein RRN3 PF05327.11 EMC77568.1 - 0.33 9.4 10.8 0.51 8.8 0.8 2.2 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 AbiEi_4 PF13338.6 EMC77568.1 - 0.76 10.0 2.6 4.1 7.6 0.0 3.2 4 0 0 4 4 4 0 Transcriptional regulator, AbiEi antitoxin Lin-8 PF03353.15 EMC77568.1 - 3.3 7.2 24.1 3.2 7.2 3.8 2.3 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist PPP4R2 PF09184.11 EMC77568.1 - 5 6.6 30.3 0.057 13.0 5.2 2.6 2 0 0 2 2 2 0 PPP4R2 DUF913 PF06025.12 EMC77568.1 - 7.5 5.4 15.7 1.1 8.1 1.7 2.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) CAP_N PF01213.19 EMC77569.1 - 0.1 12.1 1.6 0.13 11.8 1.6 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Kinesin PF00225.23 EMC77570.1 - 3e-29 102.0 0.0 3.1e-29 102.0 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EMC77570.1 - 1e-19 70.9 0.0 1.1e-19 70.8 0.0 1.0 1 0 0 1 1 1 1 Microtubule binding NACHT PF05729.12 EMC77570.1 - 0.014 15.3 0.0 0.014 15.3 0.0 1.1 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 EMC77570.1 - 0.027 14.8 0.0 0.027 14.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EMC77570.1 - 0.055 13.9 0.0 0.055 13.9 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain DUF2791 PF10923.8 EMC77570.1 - 0.063 12.1 0.0 0.063 12.1 0.0 1.1 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) DUF87 PF01935.17 EMC77570.1 - 0.1 12.7 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_30 PF13604.6 EMC77570.1 - 0.12 12.0 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 AAA domain BBP1_C PF15272.6 EMC77571.1 - 0.0085 15.9 5.0 0.0085 15.9 5.0 2.0 1 1 1 2 2 2 1 Spindle pole body component BBP1, C-terminal OmpH PF03938.14 EMC77571.1 - 0.014 15.7 2.2 0.014 15.7 2.2 2.3 1 1 0 2 2 2 0 Outer membrane protein (OmpH-like) TTKRSYEDQ PF10212.9 EMC77571.1 - 0.048 12.6 4.5 0.061 12.3 4.5 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein DUF2207 PF09972.9 EMC77571.1 - 0.31 9.7 2.2 0.41 9.4 2.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DIT1_PvcA PF05141.12 EMC77571.1 - 0.41 10.1 3.5 0.59 9.5 3.5 1.2 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein IZUMO PF15005.6 EMC77571.1 - 0.96 10.0 6.2 0.9 10.0 5.0 1.5 1 1 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated DivIC PF04977.15 EMC77571.1 - 2.9 7.7 10.3 0.51 10.1 3.3 2.4 2 0 0 2 2 2 0 Septum formation initiator AAA_23 PF13476.6 EMC77571.1 - 3.1 8.3 8.0 4.8 7.6 8.0 1.4 1 0 0 1 1 1 0 AAA domain DDOST_48kD PF03345.14 EMC77572.1 - 6e-143 476.6 0.0 6.7e-143 476.5 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta UBA PF00627.31 EMC77573.1 - 0.00018 21.3 0.1 0.00032 20.5 0.1 1.4 1 0 0 1 1 1 1 UBA/TS-N domain FF PF01846.19 EMC77575.1 - 1.4e-16 60.4 9.4 2.5e-09 37.2 3.6 2.4 2 0 0 2 2 2 2 FF domain WW PF00397.26 EMC77575.1 - 2.7e-05 24.2 0.1 2.7e-05 24.2 0.1 1.9 2 0 0 2 2 2 1 WW domain Glutaredoxin PF00462.24 EMC77576.1 - 1.2e-37 127.9 0.0 3.2e-17 62.5 0.0 3.0 3 0 0 3 3 3 2 Glutaredoxin Thioredoxin PF00085.20 EMC77576.1 - 1.2e-05 25.2 0.0 0.0001 22.2 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin SH3BGR PF04908.15 EMC77576.1 - 5.9e-05 23.2 0.0 0.16 12.2 0.0 2.6 2 0 0 2 2 2 2 SH3-binding, glutamic acid-rich protein RdRP PF05183.12 EMC77576.1 - 0.0022 16.7 0.0 0.73 8.4 0.0 2.1 1 1 1 2 2 2 2 RNA dependent RNA polymerase Thioredoxin_2 PF13098.6 EMC77576.1 - 0.0043 17.5 0.1 0.042 14.3 0.0 2.4 3 1 0 3 3 3 1 Thioredoxin-like domain HyaE PF07449.11 EMC77576.1 - 0.04 13.9 0.0 1.6 8.8 0.0 3.0 3 1 1 4 4 4 0 Hydrogenase-1 expression protein HyaE DNA_processg_A PF02481.15 EMC77576.1 - 0.097 11.9 0.0 4.7 6.4 0.0 2.5 3 0 0 3 3 3 0 DNA recombination-mediator protein A GST_N_3 PF13417.6 EMC77576.1 - 0.11 13.0 0.0 2.1 8.8 0.0 2.3 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain Cas_Csa5 PF09702.10 EMC77576.1 - 0.14 12.4 0.0 3.2 8.0 0.0 2.6 2 1 0 2 2 2 0 CRISPR-associated protein (Cas_Csa5) GerD PF17898.1 EMC77576.1 - 0.15 12.0 0.0 6.6 6.7 0.0 2.4 2 0 0 2 2 2 0 Spore germination GerD central core domain Ras PF00071.22 EMC77577.1 - 2e-56 190.0 0.1 2.4e-56 189.8 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC77577.1 - 2e-35 121.6 0.1 3.7e-35 120.7 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC77577.1 - 1.2e-12 47.6 0.1 1.4e-12 47.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC77577.1 - 0.0001 21.9 0.0 0.00016 21.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EMC77577.1 - 0.00055 19.9 0.4 0.0076 16.2 0.1 2.3 2 1 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 EMC77577.1 - 0.0015 18.6 0.0 0.0027 17.8 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMC77577.1 - 0.0037 16.7 0.0 0.0049 16.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 EMC77577.1 - 0.019 14.7 0.1 0.077 12.7 0.0 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation APP_N PF02177.16 EMC77577.1 - 0.056 13.8 0.5 6.1 7.3 0.0 2.8 2 1 1 3 3 3 0 Amyloid A4 N-terminal heparin-binding DUF92 PF01940.16 EMC77578.1 - 1.7e-78 263.3 3.6 2.8e-78 262.6 3.6 1.3 1 0 0 1 1 1 1 Integral membrane protein DUF92 zf-C3H1 PF10650.9 EMC77580.1 - 5.7e-09 35.5 4.3 1.3e-08 34.4 4.3 1.7 1 0 0 1 1 1 1 Putative zinc-finger domain TPR_17 PF13431.6 EMC77580.1 - 9.1e-08 32.0 4.4 0.018 15.4 0.2 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMC77580.1 - 0.00016 22.2 7.9 3.3 8.8 0.0 6.9 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMC77580.1 - 0.00018 21.9 8.2 0.07 13.7 0.0 6.2 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_20 PF14561.6 EMC77580.1 - 0.0002 21.6 0.0 0.092 13.1 0.0 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMC77580.1 - 0.0037 16.9 2.8 0.19 11.4 0.2 4.1 4 1 1 5 5 5 2 TPR repeat TPR_12 PF13424.6 EMC77580.1 - 0.51 10.7 3.5 6.5 7.1 0.2 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat SMAP PF15477.6 EMC77580.1 - 8.4 7.4 10.8 3.1 8.8 0.0 3.2 2 0 0 2 2 2 0 Small acidic protein family LRR_8 PF13855.6 EMC77581.1 - 2.1e-105 344.4 79.3 2.4e-15 56.0 1.2 8.1 2 2 10 12 12 12 12 Leucine rich repeat LRR_4 PF12799.7 EMC77581.1 - 7e-40 134.4 37.2 3.3e-06 27.3 0.4 9.8 6 1 5 11 11 11 11 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC77581.1 - 1.7e-36 125.0 0.0 4.1e-13 49.4 0.0 4.7 1 1 2 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC77581.1 - 2.3e-14 53.3 10.5 0.0037 16.8 0.1 5.2 1 1 3 5 5 5 5 Leucine-rich repeat LRR_1 PF00560.33 EMC77581.1 - 2.2e-11 42.6 38.0 0.98 10.2 0.0 13.8 13 2 1 14 14 14 4 Leucine Rich Repeat 7tm_1 PF00001.21 EMC77581.1 - 6.4e-11 42.1 16.1 9.9e-11 41.4 15.5 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC77581.1 - 0.00037 20.2 8.0 0.00037 20.2 8.0 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx rpo132 PF12415.8 EMC77581.1 - 0.13 11.5 0.2 0.33 10.3 0.2 1.7 1 0 0 1 1 1 0 Poxvirus DNA dependent RNA polymerase Tetraspanin PF00335.20 EMC77582.1 - 4.5e-49 167.2 18.0 5e-49 167.1 18.0 1.0 1 0 0 1 1 1 1 Tetraspanin family Phage_holin_3_6 PF07332.11 EMC77582.1 - 0.02 14.9 0.8 0.02 14.9 0.8 2.3 2 1 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4834 PF16118.5 EMC77582.1 - 0.25 12.3 0.2 0.25 12.3 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Y_phosphatase PF00102.27 EMC77583.1 - 2e-75 253.4 1.3 3.1e-75 252.7 0.1 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EMC77583.1 - 0.0002 21.4 0.0 0.00053 20.0 0.0 1.6 2 0 0 2 2 2 1 Tyrosine phosphatase family DSPc PF00782.20 EMC77583.1 - 0.00033 20.5 0.0 0.00087 19.1 0.0 1.8 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CyRPA PF18638.1 EMC77583.1 - 0.024 13.8 0.1 0.038 13.2 0.1 1.2 1 0 0 1 1 1 0 Cysteine-Rich Protective Antigen 6 bladed domain PTPlike_phytase PF14566.6 EMC77583.1 - 0.049 13.8 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 Inositol hexakisphosphate Shisa PF13908.6 EMC77583.1 - 0.098 12.9 0.2 0.17 12.1 0.2 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator WBP-1 PF11669.8 EMC77583.1 - 0.11 13.2 0.2 0.27 11.9 0.2 1.6 1 0 0 1 1 1 0 WW domain-binding protein 1 DUF3149 PF11346.8 EMC77583.1 - 0.99 9.1 4.1 2.2 8.0 4.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) BtpA PF03437.15 EMC77584.1 - 4.4e-33 114.8 0.0 4.7e-33 114.7 0.0 1.0 1 0 0 1 1 1 1 BtpA family Cyclin_N PF00134.23 EMC77585.1 - 2.1e-43 147.1 1.9 3.3e-43 146.4 1.9 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EMC77585.1 - 4.5e-18 65.4 0.0 9.1e-18 64.5 0.0 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain Prefoldin PF02996.17 EMC77586.1 - 3.8e-14 52.6 0.0 9.3e-14 51.4 0.0 1.7 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_3 PF13758.6 EMC77586.1 - 5.3e-07 29.6 0.1 2.5e-06 27.4 0.0 2.3 2 0 0 2 2 2 1 Prefoldin subunit SIN1 PF05422.12 EMC77586.1 - 0.0069 16.9 0.9 0.0069 16.9 0.9 2.5 3 0 0 3 3 3 1 Stress-activated map kinase interacting protein 1 (SIN1) Cupredoxin_1 PF13473.6 EMC77586.1 - 0.096 12.8 0.2 0.32 11.1 0.2 1.8 1 0 0 1 1 1 0 Cupredoxin-like domain DUF3835 PF12927.7 EMC77586.1 - 0.13 13.1 0.2 0.13 13.1 0.2 4.0 3 1 1 4 4 4 0 Domain of unknown function (DUF3835) DUF1639 PF07797.14 EMC77586.1 - 1 9.4 4.0 1.6 8.8 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1639) zf-C2H2_assoc PF16606.5 EMC77587.1 - 2.5e-40 136.5 17.5 2.5e-40 136.5 17.5 2.7 2 0 0 2 2 2 1 Unstructured conserved, between two C2H2-type zinc-fingers zf-C2H2 PF00096.26 EMC77587.1 - 6.9e-32 108.1 74.1 2.3e-05 24.6 4.0 10.4 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC77587.1 - 1.7e-25 87.5 75.5 0.0022 18.7 2.8 10.6 10 0 0 10 10 10 9 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC77587.1 - 6e-20 70.7 81.2 6.7e-08 32.6 2.4 12.5 13 0 0 13 13 12 5 Zinc-finger double domain zf-H2C2_5 PF13909.6 EMC77587.1 - 9.3e-15 54.1 61.0 2.8e-07 30.1 0.9 10.3 11 0 0 11 11 11 4 C2H2-type zinc-finger domain zf-Di19 PF05605.12 EMC77587.1 - 1.5e-07 31.6 49.1 0.0061 16.8 1.7 7.7 6 3 1 7 7 7 5 Drought induced 19 protein (Di19), zinc-binding GAGA PF09237.11 EMC77587.1 - 0.0022 17.7 10.3 0.7 9.7 0.1 5.5 5 2 2 7 7 7 1 GAGA factor Zn-ribbon_8 PF09723.10 EMC77587.1 - 0.0063 16.6 32.6 0.52 10.5 3.3 6.2 5 2 1 6 6 6 3 Zinc ribbon domain zf-C2H2_2 PF12756.7 EMC77587.1 - 0.007 16.7 42.5 4.6 7.6 0.1 9.9 5 3 3 9 9 9 2 C2H2 type zinc-finger (2 copies) Actin_micro PF17003.5 EMC77587.1 - 0.011 15.0 23.3 6.4 5.8 0.2 6.0 4 2 0 4 4 4 0 Putative actin-like family DUF3268 PF11672.8 EMC77587.1 - 0.033 14.5 15.2 0.035 14.4 1.2 4.0 4 0 0 4 4 3 0 zinc-finger-containing domain CpXC PF14353.6 EMC77587.1 - 0.063 13.3 26.3 13 5.9 0.4 7.1 5 3 3 8 8 7 0 CpXC protein TerY_C PF15616.6 EMC77587.1 - 0.37 10.9 7.7 10 6.2 0.0 3.6 4 0 0 4 4 3 0 TerY-C metal binding domain DZR PF12773.7 EMC77587.1 - 0.42 10.7 22.0 0.14 12.2 0.4 5.5 5 1 0 5 5 5 0 Double zinc ribbon ARS2 PF04959.13 EMC77587.1 - 3.3 8.1 13.6 9 6.6 0.0 4.7 3 1 1 4 4 4 0 Arsenite-resistance protein 2 zf_C2H2_ZHX PF18387.1 EMC77587.1 - 5.7 6.7 25.6 0.63 9.7 0.4 5.8 4 2 2 6 6 6 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_3rep PF18868.1 EMC77587.1 - 6.3 7.5 26.0 0.025 15.2 3.4 5.6 5 2 2 7 7 7 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_jaz PF12171.8 EMC77587.1 - 8.3 6.8 38.5 0.23 11.8 0.2 8.8 9 0 0 9 9 9 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EMC77588.1 - 2.5e-10 40.6 20.7 0.0067 16.7 1.2 5.2 3 2 0 4 4 4 4 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EMC77588.1 - 1.9e-09 37.5 27.3 0.034 14.6 2.9 5.7 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC77588.1 - 2.4e-08 34.1 22.0 0.063 14.2 2.6 5.7 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC77588.1 - 7.5e-06 25.8 21.5 0.024 14.6 2.4 4.6 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.7 EMC77588.1 - 0.00046 20.5 7.0 0.026 14.9 2.1 3.1 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2HE PF16278.5 EMC77588.1 - 0.0027 18.1 11.0 2.5 8.6 0.0 5.1 5 0 0 5 5 5 2 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.8 EMC77588.1 - 0.0071 16.6 14.9 0.058 13.7 0.8 4.6 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 EMC77588.1 - 0.038 14.1 10.1 6.4 7.0 0.1 5.0 5 0 0 5 5 5 0 Zinc ribbon domain DUF678 PF05077.12 EMC77588.1 - 0.065 13.4 3.7 20 5.4 0.0 4.5 4 0 0 4 4 4 0 Protein of unknown function (DUF678) zf-C2H2_3rep PF18868.1 EMC77588.1 - 0.096 13.4 15.4 0.43 11.3 0.8 5.1 4 1 1 5 5 5 0 Zinc finger C2H2-type, 3 repeats PyrI_C PF02748.15 EMC77588.1 - 0.16 11.9 2.3 4.5 7.2 0.1 3.3 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Homeodomain PF00046.29 EMC77588.1 - 0.21 11.4 0.4 0.92 9.4 0.2 2.4 2 0 0 2 2 2 0 Homeodomain zf-C2HC_2 PF13913.6 EMC77588.1 - 0.37 10.7 1.4 0.53 10.3 0.1 1.9 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-H2C2_2 PF13465.6 EMC77588.1 - 0.92 10.1 12.9 3.1 8.4 0.1 5.2 5 0 0 5 5 4 0 Zinc-finger double domain zf-C2H2_11 PF16622.5 EMC77588.1 - 1.2 8.9 14.4 0.34 10.7 2.1 3.9 4 0 0 4 4 4 0 zinc-finger C2H2-type OTT_1508_deam PF14441.6 EMC77588.1 - 1.7 8.7 4.3 3.8 7.6 0.1 3.0 3 0 0 3 3 3 0 OTT_1508-like deaminase zf-CpG_bind_C PF12269.8 EMC77588.1 - 3.6 7.3 12.2 0.35 10.6 0.4 3.4 5 0 0 5 5 5 0 CpG binding protein zinc finger C terminal domain zf-C2H2_9 PF16293.5 EMC77588.1 - 5.9 6.8 11.0 4.6 7.2 0.2 4.4 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-C2H2 PF00096.26 EMC77589.1 - 2.8e-13 49.5 66.1 0.011 16.1 3.3 8.6 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC77589.1 - 5.6e-12 45.4 62.5 0.0092 16.8 3.2 8.6 8 0 0 8 8 8 7 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC77589.1 - 3.3e-05 24.1 60.3 0.00026 21.3 2.0 10.0 11 0 0 11 11 11 4 Zinc-finger double domain DUF5069 PF16798.5 EMC77589.1 - 0.31 11.2 1.7 8.1 6.7 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF5069) zf-H2C2_5 PF13909.6 EMC77589.1 - 2.3 8.0 67.1 0.047 13.5 1.0 8.6 9 0 0 9 9 9 0 C2H2-type zinc-finger domain zf_C2H2_ZHX PF18387.1 EMC77589.1 - 5.8 6.6 44.9 0.095 12.4 3.3 7.8 6 2 2 8 8 8 0 Zinc-fingers and homeoboxes C2H2 finger domain Dpy19 PF10034.9 EMC77590.1 - 7.1e-242 804.3 35.0 8.3e-242 804.1 35.0 1.0 1 0 0 1 1 1 1 Q-cell neuroblast polarisation Cadherin PF00028.17 EMC77591.1 - 8.9e-220 712.0 17.4 7e-20 71.3 0.0 15.3 15 0 0 15 15 15 15 Cadherin domain Laminin_G_2 PF02210.24 EMC77591.1 - 6e-33 114.1 0.0 1e-15 58.5 0.0 2.8 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 EMC77591.1 - 2.6e-25 89.2 0.0 1.7e-11 44.4 0.0 3.0 2 1 0 2 2 2 2 Laminin G domain EGF PF00008.27 EMC77591.1 - 3.8e-14 52.6 49.3 7e-07 29.4 6.0 4.9 4 0 0 4 4 4 4 EGF-like domain Cadherin_C PF01049.17 EMC77591.1 - 7.3e-12 45.8 0.4 1.7e-11 44.6 0.4 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_2 PF08266.12 EMC77591.1 - 4.4e-11 42.5 0.0 0.06 13.2 0.0 8.2 8 0 0 8 8 8 1 Cadherin-like Cadherin_pro PF08758.11 EMC77591.1 - 5.5e-10 39.3 0.0 3.8e-06 27.0 0.0 6.0 6 0 0 6 6 6 1 Cadherin prodomain like Cadherin_3 PF16184.5 EMC77591.1 - 3.4e-09 36.7 20.3 0.079 13.0 0.1 9.3 11 0 0 11 11 11 4 Cadherin-like hEGF PF12661.7 EMC77591.1 - 3.1e-07 30.8 37.0 0.0011 19.5 3.7 5.0 4 0 0 4 4 4 3 Human growth factor-like EGF RET_CLD1 PF17756.1 EMC77591.1 - 3.6e-06 27.3 0.0 43 4.4 0.0 6.7 7 0 0 7 7 6 0 RET Cadherin like domain 1 Cadherin_4 PF17803.1 EMC77591.1 - 0.0013 19.3 1.2 0.0013 19.3 1.2 11.6 15 0 0 15 15 12 3 Bacterial cadherin-like domain EGF_2 PF07974.13 EMC77591.1 - 0.0035 17.7 53.9 0.0048 17.2 5.0 4.8 4 0 0 4 4 3 3 EGF-like domain Y_Y_Y PF07495.13 EMC77591.1 - 0.15 12.1 0.0 23 5.0 0.0 4.8 5 0 0 5 5 5 0 Y_Y_Y domain dsDNA_bind PF01984.20 EMC77592.1 - 1.5e-30 105.7 5.0 1.7e-30 105.5 5.0 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain Methyltransf_4 PF02390.17 EMC77592.1 - 0.054 13.0 0.6 0.071 12.6 0.1 1.5 2 0 0 2 2 2 0 Putative methyltransferase Tropomodulin PF03250.14 EMC77592.1 - 0.063 13.3 1.3 0.62 10.1 0.1 2.1 2 0 0 2 2 2 0 Tropomodulin Ank_2 PF12796.7 EMC77593.1 - 8.6e-55 183.3 9.1 1.9e-15 57.2 2.6 6.4 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 EMC77593.1 - 6.1e-47 156.1 23.7 3.7e-07 30.3 0.2 9.5 10 0 0 10 10 10 8 Ankyrin repeat Ank_4 PF13637.6 EMC77593.1 - 1.8e-44 149.6 18.1 5.3e-10 39.6 0.6 9.5 4 3 5 9 9 9 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC77593.1 - 6.9e-44 147.4 15.5 7.6e-11 42.0 0.7 9.3 5 2 5 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC77593.1 - 4.9e-40 130.9 13.4 0.00015 21.9 0.1 10.2 9 0 0 9 9 9 9 Ankyrin repeat VPS9 PF02204.18 EMC77593.1 - 2.4e-23 82.3 1.1 1e-22 80.3 0.3 2.5 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain PEGA PF08308.11 EMC77593.1 - 0.13 12.2 0.0 3.5 7.6 0.0 3.2 3 0 0 3 3 3 0 PEGA domain Syntaxin_2 PF14523.6 EMC77594.1 - 0.0013 19.1 0.5 0.0021 18.4 0.3 1.5 2 0 0 2 2 2 1 Syntaxin-like protein Tic110 PF16940.5 EMC77594.1 - 0.0057 15.2 0.2 0.0075 14.8 0.2 1.1 1 0 0 1 1 1 1 Chloroplast envelope transporter LapD_MoxY_N PF16448.5 EMC77594.1 - 0.02 14.8 0.2 0.044 13.7 0.0 1.6 2 0 0 2 2 2 0 LapD/MoxY periplasmic domain DUF2155 PF09923.9 EMC77594.1 - 0.041 14.1 0.4 0.4 11.0 0.4 2.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2155) DUF1539 PF07560.11 EMC77594.1 - 0.044 13.9 0.1 0.092 12.8 0.1 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1539) TUDOR PF00567.24 EMC77596.1 - 1.4e-11 44.5 1.8 1.7e-11 44.2 1.8 1.1 1 0 0 1 1 1 1 Tudor domain TUDOR PF00567.24 EMC77597.1 - 3.3e-10 40.0 0.1 8.3e-10 38.7 0.1 1.6 1 0 0 1 1 1 1 Tudor domain DEAD PF00270.29 EMC77597.1 - 1.8e-06 27.8 0.0 4.7e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC77597.1 - 2.2e-05 24.8 0.1 8.1e-05 22.9 0.1 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Ca_bind_SSO6904 PF18249.1 EMC77597.1 - 0.026 14.8 0.2 0.13 12.7 0.1 2.3 2 0 0 2 2 2 0 Calcium binding protein SSO6904 AA_permease_2 PF13520.6 EMC77598.1 - 5.6e-62 209.9 46.6 7e-62 209.6 46.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMC77598.1 - 5.1e-26 91.3 42.8 6.9e-26 90.9 42.8 1.0 1 0 0 1 1 1 1 Amino acid permease Pdase_M17_N2 PF18295.1 EMC77599.1 - 0.82 9.9 4.5 0.6 10.4 0.3 2.8 2 1 1 3 3 3 0 M17 aminopeptidase N-terminal domain 2 Toprim_C_rpt PF13368.6 EMC77599.1 - 2.4 8.2 5.6 1.3 9.1 0.3 2.6 2 0 0 2 2 2 0 Topoisomerase C-terminal repeat PND PF17949.1 EMC77600.1 - 1.7e-51 173.7 0.4 2.7e-51 173.1 0.1 1.5 2 0 0 2 2 2 1 FANCM pseudonuclease domain HHH_2 PF12826.7 EMC77600.1 - 2.6e-09 37.0 0.0 4.9e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 EMC77600.1 - 9.4e-06 26.1 0.0 1.7e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix domain 5_3_exonuc PF01367.20 EMC77600.1 - 0.014 16.0 0.0 0.026 15.1 0.0 1.4 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold Rad10 PF03834.14 EMC77600.1 - 0.015 15.3 0.0 0.031 14.3 0.0 1.6 1 1 0 1 1 1 0 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH PF00633.23 EMC77600.1 - 0.044 13.7 0.1 4.1 7.5 0.0 3.1 3 1 0 3 3 3 0 Helix-hairpin-helix motif BRO1 PF03097.18 EMC77601.1 - 3.5e-95 319.1 0.1 4.7e-95 318.6 0.1 1.1 1 0 0 1 1 1 1 BRO1-like domain HR1 PF02185.16 EMC77601.1 - 1.7e-13 50.5 6.6 1.9e-13 50.3 4.0 2.6 2 0 0 2 2 2 1 Hr1 repeat PDZ_6 PF17820.1 EMC77601.1 - 3e-07 30.2 0.0 7.1e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 EMC77601.1 - 9.5e-07 29.1 0.0 2.8e-06 27.6 0.0 1.8 2 0 0 2 2 2 1 PDZ domain DUF1604 PF07713.13 EMC77602.1 - 2.7e-35 120.0 0.4 2.7e-35 120.0 0.4 4.2 5 0 0 5 5 5 1 Protein of unknown function (DUF1604) G-patch PF01585.23 EMC77602.1 - 5.1e-07 29.5 1.9 7.9e-07 28.9 0.2 2.2 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 EMC77602.1 - 0.0018 18.3 0.0 0.0018 18.3 0.0 3.5 2 1 0 2 2 2 1 G-patch domain WD40 PF00400.32 EMC77603.1 - 5.7e-37 125.1 28.0 3e-07 31.0 0.6 6.1 6 0 0 6 6 6 6 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 EMC77603.1 - 2e-07 29.9 0.1 0.00018 20.1 0.0 2.0 1 1 1 2 2 2 2 Cytochrome D1 heme domain ANAPC4_WD40 PF12894.7 EMC77603.1 - 2.6e-06 27.7 0.3 1.3 9.4 0.0 4.1 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMC77603.1 - 8e-06 24.8 5.9 0.12 11.0 0.1 3.8 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EMC77603.1 - 2e-05 23.7 1.3 0.0089 15.0 0.4 3.3 1 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EMC77603.1 - 0.00013 21.9 1.1 0.043 13.7 0.1 2.5 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A PQQ PF01011.21 EMC77603.1 - 0.00016 21.4 0.1 0.001 18.9 0.1 2.2 2 0 0 2 2 2 1 PQQ enzyme repeat PQQ_2 PF13360.6 EMC77603.1 - 0.00048 19.8 0.0 0.00094 18.8 0.0 1.6 1 1 0 1 1 1 1 PQQ-like domain Frtz PF11768.8 EMC77603.1 - 0.0027 16.1 1.0 0.067 11.5 0.2 2.2 1 1 1 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz PQQ_3 PF13570.6 EMC77603.1 - 0.0068 16.9 0.0 9.8 6.8 0.0 3.5 4 0 0 4 4 4 1 PQQ-like domain HNH_2 PF13391.6 EMC77603.1 - 0.039 14.1 0.3 1.4 9.1 0.0 2.4 2 0 0 2 2 2 0 HNH endonuclease Fn3-like PF14310.6 EMC77603.1 - 0.16 12.1 0.1 15 5.8 0.0 2.6 2 0 0 2 2 2 0 Fibronectin type III-like domain Ldl_recept_a PF00057.18 EMC77604.1 - 3.9e-42 142.2 82.4 7.8e-13 48.4 10.9 5.5 5 0 0 5 5 5 5 Low-density lipoprotein receptor domain class A CUB PF00431.20 EMC77604.1 - 5.9e-18 65.2 0.2 1e-07 32.2 0.0 2.4 2 0 0 2 2 2 2 CUB domain Syndecan PF01034.20 EMC77604.1 - 0.22 11.5 0.8 0.37 10.7 0.8 1.3 1 0 0 1 1 1 0 Syndecan domain AA_permease_2 PF13520.6 EMC77605.1 - 6.6e-61 206.4 41.1 8.2e-61 206.1 41.1 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMC77605.1 - 6.8e-33 114.0 35.5 8.4e-33 113.7 35.5 1.1 1 0 0 1 1 1 1 Amino acid permease p53-inducible11 PF14936.6 EMC77605.1 - 0.52 10.3 9.9 2.4 8.2 1.7 2.5 2 0 0 2 2 2 0 Tumour protein p53-inducible protein 11 DUF5408 PF17402.2 EMC77605.1 - 0.97 9.4 3.4 2.9 7.8 3.4 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5408) bZIP_2 PF07716.15 EMC77606.1 - 5.1e-13 48.9 14.7 9.2e-12 44.9 15.2 2.2 1 1 1 2 2 2 2 Basic region leucine zipper bZIP_1 PF00170.21 EMC77606.1 - 0.0014 18.7 5.7 0.0032 17.5 5.7 1.6 1 0 0 1 1 1 1 bZIP transcription factor Hema_stalk PF08720.10 EMC77606.1 - 0.13 12.0 0.2 0.17 11.5 0.2 1.1 1 0 0 1 1 1 0 Influenza C hemagglutinin stalk IBB PF01749.20 EMC77606.1 - 0.18 12.2 10.7 0.31 11.5 10.7 1.4 1 0 0 1 1 1 0 Importin beta binding domain CENP-H PF05837.12 EMC77606.1 - 0.24 11.8 6.0 0.47 10.9 6.0 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) bZIP_2 PF07716.15 EMC77607.1 - 1.4e-15 57.1 16.9 1.9e-15 56.7 16.9 1.2 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EMC77607.1 - 2e-05 24.6 12.4 3.6e-05 23.8 12.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor DUF1319 PF07028.11 EMC77607.1 - 0.016 15.4 1.6 0.023 14.9 1.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1319) Jnk-SapK_ap_N PF09744.9 EMC77607.1 - 0.035 14.3 6.4 0.048 13.9 6.4 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 bZIP_Maf PF03131.17 EMC77607.1 - 0.044 14.3 7.7 0.077 13.5 7.7 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor Seryl_tRNA_N PF02403.22 EMC77607.1 - 0.048 13.9 6.9 0.079 13.2 6.9 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain APG6_N PF17675.1 EMC77607.1 - 0.12 12.9 6.9 0.18 12.3 6.9 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region XhlA PF10779.9 EMC77607.1 - 0.19 11.9 6.4 0.19 12.0 5.2 1.6 1 1 0 1 1 1 0 Haemolysin XhlA DUF4094 PF13334.6 EMC77607.1 - 0.34 11.3 3.2 0.52 10.8 3.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) DivIC PF04977.15 EMC77607.1 - 0.38 10.6 7.7 0.38 10.5 6.5 1.6 1 1 0 1 1 1 0 Septum formation initiator Tho2 PF11262.8 EMC77607.1 - 0.93 8.6 6.0 1.1 8.3 6.0 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 LAM_C PF12544.8 EMC77607.1 - 1.8 8.8 6.6 11 6.1 6.6 2.2 1 1 0 1 1 1 0 Lysine-2,3-aminomutase Peptidase_M24 PF00557.24 EMC77608.1 - 3.8e-48 163.9 0.0 8.7e-45 153.0 0.0 3.3 2 1 1 3 3 3 3 Metallopeptidase family M24 AMP_N PF05195.16 EMC77608.1 - 1.1e-27 96.3 0.0 2.2e-27 95.2 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Sulfotransfer_2 PF03567.14 EMC77609.1 - 1.9e-41 142.6 3.6 2.1e-41 142.5 3.6 1.0 1 0 0 1 1 1 1 Sulfotransferase family TAF4 PF05236.14 EMC77610.1 - 4.8e-77 259.4 7.2 5.5e-77 259.2 7.2 1.0 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family TAF PF02969.17 EMC77610.1 - 3.5e-05 23.9 0.3 0.22 11.7 0.1 2.5 2 0 0 2 2 2 2 TATA box binding protein associated factor (TAF) Presenilin PF01080.17 EMC77610.1 - 0.035 12.9 1.5 0.045 12.5 1.5 1.1 1 0 0 1 1 1 0 Presenilin DUF1955 PF09205.10 EMC77610.1 - 0.16 11.7 0.5 0.26 11.0 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1955) Glu-tRNAGln PF02686.15 EMC77610.1 - 0.57 10.5 3.1 1.7 9.0 1.3 2.5 1 1 1 2 2 2 0 Glu-tRNAGln amidotransferase C subunit LSM14 PF12701.7 EMC77611.1 - 1.6e-33 114.6 0.0 2.7e-33 113.9 0.0 1.4 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 EMC77611.1 - 4.9e-31 107.7 11.2 5.1e-31 107.7 7.8 2.1 2 0 0 2 2 2 1 FDF domain SM-ATX PF14438.6 EMC77611.1 - 5.6e-08 32.8 0.0 1e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain GRP PF07172.11 EMC77611.1 - 1.2 9.9 18.5 11 6.8 0.4 2.6 2 0 0 2 2 2 0 Glycine rich protein family DUF4745 PF15923.5 EMC77612.1 - 1.2e-47 161.2 1.8 2.8e-47 160.0 1.8 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4745) Rapsyn_N PF10579.9 EMC77612.1 - 0.076 13.1 0.0 5.6 7.1 0.0 3.0 3 0 0 3 3 3 0 Rapsyn N-terminal myristoylation and linker region Pex14_N PF04695.13 EMC77612.1 - 9.1 6.9 24.8 0.054 14.1 8.2 3.4 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region LIM PF00412.22 EMC77613.1 - 5e-36 122.7 36.5 4e-14 52.6 8.4 3.1 3 0 0 3 3 3 3 LIM domain Mut7-C PF01927.16 EMC77613.1 - 9 6.4 20.1 0.072 13.2 2.0 3.2 1 1 3 4 4 4 0 Mut7-C RNAse domain ThiF PF00899.21 EMC77614.1 - 3.7e-57 193.5 0.1 5.8e-57 192.9 0.1 1.3 1 0 0 1 1 1 1 ThiF family UBA2_C PF16195.5 EMC77614.1 - 2.3e-24 85.9 11.5 2.3e-24 85.9 11.5 2.2 3 0 0 3 3 3 1 SUMO-activating enzyme subunit 2 C-terminus UAE_UbL PF14732.6 EMC77614.1 - 1.1e-22 80.4 1.1 1.1e-22 80.4 1.1 2.0 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 EMC77614.1 - 1.9e-06 28.0 8.2 0.0022 18.0 0.4 2.7 2 1 1 3 3 3 2 Ubiquitin-activating enzyme active site PDCD2_C PF04194.13 EMC77615.1 - 6.7e-46 156.6 0.4 1e-45 155.9 0.4 1.3 1 0 0 1 1 1 1 Programmed cell death protein 2, C-terminal putative domain Glyco_transf_92 PF01697.27 EMC77615.1 - 0.068 12.8 0.2 0.12 12.0 0.2 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 92 COesterase PF00135.28 EMC77616.1 - 2.7e-165 551.1 0.0 3e-165 551.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMC77616.1 - 1.3e-07 31.7 1.5 4.9e-07 29.8 1.5 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EMC77616.1 - 0.0038 16.7 0.0 0.0068 15.9 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EMC77616.1 - 0.021 15.4 0.7 0.046 14.3 0.2 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase family COesterase PF00135.28 EMC77617.1 - 1e-34 120.3 0.0 1.2e-34 120.1 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.28 EMC77618.1 - 5.7e-101 338.9 0.0 6.3e-101 338.8 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMC77618.1 - 4.2e-09 36.6 1.1 2.2e-08 34.2 1.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EMC77618.1 - 0.031 13.7 0.1 0.059 12.8 0.1 1.5 2 0 0 2 2 2 0 Prolyl oligopeptidase family COesterase PF00135.28 EMC77619.1 - 1.6e-125 419.9 0.0 1.8e-125 419.7 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMC77619.1 - 7.2e-09 35.8 1.5 1.9e-08 34.4 1.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EMC77619.1 - 0.00038 20.0 0.0 0.00057 19.4 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 EMC77619.1 - 0.0011 18.6 0.0 0.0019 17.9 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.7 EMC77619.1 - 0.008 16.8 0.3 0.017 15.7 0.3 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Say1_Mug180 PF10340.9 EMC77619.1 - 0.075 11.9 0.1 0.19 10.6 0.1 1.6 1 1 0 1 1 1 0 Steryl acetyl hydrolase PRAI PF00697.22 EMC77619.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase COesterase PF00135.28 EMC77620.1 - 4.2e-162 540.6 0.0 4.8e-162 540.4 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMC77620.1 - 4.7e-10 39.7 1.0 1.6e-09 37.9 0.9 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 EMC77620.1 - 0.00064 19.4 0.0 0.0012 18.5 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 EMC77620.1 - 0.00084 18.9 0.0 0.0015 18.0 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EMC77620.1 - 0.015 15.9 1.5 0.026 15.1 1.1 1.7 1 1 0 1 1 1 0 Alpha/beta hydrolase family Say1_Mug180 PF10340.9 EMC77620.1 - 0.083 11.7 0.0 0.18 10.6 0.0 1.4 1 1 0 1 1 1 0 Steryl acetyl hydrolase FeS_assembly_P PF01883.19 EMC77621.1 - 2.4e-07 30.8 0.0 7.1e-07 29.3 0.0 1.7 1 1 0 1 1 1 1 Iron-sulfur cluster assembly protein Ras PF00071.22 EMC77622.1 - 3.4e-31 108.0 0.0 4.8e-31 107.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC77622.1 - 1.2e-09 38.4 0.0 2.2e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EMC77622.1 - 0.0012 18.8 0.1 0.79 9.6 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Arf PF00025.21 EMC77622.1 - 0.0015 18.0 0.0 0.0023 17.4 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family FeoB_N PF02421.18 EMC77622.1 - 0.002 17.7 0.1 0.019 14.5 0.1 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_22 PF13401.6 EMC77622.1 - 0.011 16.0 0.6 6.3 7.1 0.1 3.1 1 1 1 3 3 3 0 AAA domain ABC_tran PF00005.27 EMC77622.1 - 0.022 15.2 0.3 0.069 13.7 0.3 1.9 1 1 0 1 1 1 0 ABC transporter MMR_HSR1 PF01926.23 EMC77622.1 - 0.038 14.1 0.0 0.075 13.1 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.6 EMC77622.1 - 0.051 14.1 0.1 0.11 13.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 EMC77622.1 - 0.051 14.0 0.3 0.45 10.9 0.3 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EMC77622.1 - 0.068 12.9 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EMC77622.1 - 0.071 13.5 0.8 0.33 11.3 0.3 2.2 1 1 1 2 2 2 0 AAA ATPase domain AAA_5 PF07728.14 EMC77622.1 - 0.13 12.3 0.2 0.36 10.8 0.2 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) HA1 PF18239.1 EMC77622.1 - 0.17 11.7 0.0 0.48 10.3 0.0 1.8 1 0 0 1 1 1 0 Hemagglutinin I PP2C PF00481.21 EMC77623.1 - 6.9e-40 137.3 0.0 3.3e-37 128.5 0.0 2.2 1 1 0 1 1 1 1 Protein phosphatase 2C DUF3071 PF11268.8 EMC77623.1 - 0.075 13.1 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) Carb_anhydrase PF00194.21 EMC77624.1 - 1.4e-99 332.8 0.0 1.6e-99 332.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase ThiF PF00899.21 EMC77625.1 - 6.3e-14 51.9 0.0 2e-13 50.3 0.0 1.9 1 1 0 1 1 1 1 ThiF family E1_4HB PF16191.5 EMC77625.1 - 4e-05 23.7 0.0 0.024 14.8 0.0 3.4 3 0 0 3 3 3 2 Ubiquitin-activating enzyme E1 four-helix bundle Transket_pyr PF02779.24 EMC77625.1 - 0.03 14.0 0.4 0.062 13.0 0.4 1.4 1 0 0 1 1 1 0 Transketolase, pyrimidine binding domain Atx10homo_assoc PF09759.9 EMC77626.1 - 0.00028 20.8 12.8 0.046 13.7 0.2 4.7 4 2 1 5 5 5 3 Spinocerebellar ataxia type 10 protein domain RICTOR_V PF14668.6 EMC77626.1 - 0.27 11.5 1.2 3.2 8.1 0.1 2.9 2 1 1 3 3 3 0 Rapamycin-insensitive companion of mTOR, domain 5 DLIC PF05783.11 EMC77627.1 - 4.6e-253 840.1 0.0 5.3e-253 840.0 0.0 1.0 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) ABC_tran PF00005.27 EMC77627.1 - 0.002 18.6 0.0 0.0038 17.7 0.0 1.6 1 0 0 1 1 1 1 ABC transporter Roc PF08477.13 EMC77627.1 - 0.012 15.8 0.2 0.056 13.7 0.0 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 EMC77627.1 - 0.023 14.6 0.0 0.041 13.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 EMC77627.1 - 0.025 15.0 0.1 0.056 13.8 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EMC77627.1 - 0.027 14.2 0.2 0.063 13.0 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EMC77627.1 - 0.034 14.1 0.2 8.8 6.2 0.1 2.5 2 0 0 2 2 2 0 RsgA GTPase Arf PF00025.21 EMC77627.1 - 0.034 13.6 0.2 0.48 9.9 0.0 2.5 3 0 0 3 3 3 0 ADP-ribosylation factor family AAA_22 PF13401.6 EMC77627.1 - 0.039 14.2 0.0 0.11 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 EMC77627.1 - 0.043 13.4 0.1 9.3 5.7 0.1 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 EMC77627.1 - 0.051 13.3 0.1 0.09 12.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EMC77627.1 - 0.051 13.3 0.1 0.17 11.6 0.1 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Kinesin PF00225.23 EMC77627.1 - 0.1 11.5 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Kinesin motor domain ATPase PF06745.13 EMC77627.1 - 0.12 11.8 0.0 0.27 10.5 0.0 1.6 2 0 0 2 2 2 0 KaiC AAA_23 PF13476.6 EMC77627.1 - 0.16 12.5 0.0 0.32 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.20 EMC77627.1 - 0.16 11.1 0.0 0.31 10.2 0.0 1.5 1 0 0 1 1 1 0 G-protein alpha subunit AAA_7 PF12775.7 EMC77627.1 - 0.16 11.4 0.2 0.76 9.3 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region SRP54 PF00448.22 EMC77627.1 - 0.33 10.6 0.9 0.73 9.4 0.4 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MARVEL PF01284.23 EMC77628.1 - 7e-14 52.1 14.8 1e-13 51.5 14.8 1.2 1 0 0 1 1 1 1 Membrane-associating domain YfhO PF09586.10 EMC77628.1 - 0.00052 18.4 0.6 0.00059 18.2 0.6 1.0 1 0 0 1 1 1 1 Bacterial membrane protein YfhO YIF1 PF03878.15 EMC77628.1 - 0.24 10.9 5.0 0.42 10.1 4.9 1.3 1 1 0 1 1 1 0 YIF1 DUF373 PF04123.13 EMC77628.1 - 0.64 9.4 3.9 2 7.8 4.3 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF373) MARVEL PF01284.23 EMC77629.1 - 2.9e-08 33.8 18.6 5.4e-08 33.0 18.6 1.5 1 1 0 1 1 1 1 Membrane-associating domain Cad PF03596.13 EMC77629.1 - 0.68 9.8 5.0 0.092 12.6 1.4 1.4 2 0 0 2 2 2 0 Cadmium resistance transporter CbiQ PF02361.16 EMC77629.1 - 2 8.0 6.8 2.3 7.8 6.8 1.1 1 0 0 1 1 1 0 Cobalt transport protein Deltameth_res PF16020.5 EMC77629.1 - 3.7 7.5 4.7 15 5.5 0.9 2.6 2 0 0 2 2 2 0 Deltamethrin resistance MARVEL PF01284.23 EMC77630.1 - 0.00037 20.6 17.9 0.0025 17.9 17.9 2.2 1 1 0 1 1 1 1 Membrane-associating domain DUF3792 PF12670.7 EMC77630.1 - 0.05 13.8 11.6 0.047 13.9 10.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3792) dNK PF01712.19 EMC77631.1 - 1.8e-25 90.0 1.5 2.1e-25 89.8 1.5 1.0 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.6 EMC77631.1 - 0.00057 20.4 0.0 0.00081 19.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EMC77631.1 - 0.00058 20.0 0.0 0.00089 19.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EMC77631.1 - 0.0011 18.7 0.1 0.0017 18.1 0.1 1.3 1 1 0 1 1 1 1 Thymidylate kinase AAA_17 PF13207.6 EMC77631.1 - 0.009 16.4 0.1 0.017 15.5 0.0 1.5 2 0 0 2 2 2 1 AAA domain Herpes_UL56 PF04534.12 EMC77632.1 - 0.097 12.1 0.6 0.16 11.5 0.6 1.3 1 0 0 1 1 1 0 Herpesvirus UL56 protein CYYR1 PF10873.8 EMC77632.1 - 1.2 9.5 5.4 1.9 8.9 1.2 2.2 2 0 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 Cadherin PF00028.17 EMC77633.1 - 3.6e-69 229.3 10.4 2.2e-19 69.7 0.6 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 EMC77633.1 - 4e-44 150.4 0.6 7.5e-44 149.6 0.6 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_pro PF08758.11 EMC77633.1 - 0.0042 17.2 0.2 1.7 8.9 0.0 3.1 3 0 0 3 3 3 2 Cadherin prodomain like Cadherin_2 PF08266.12 EMC77633.1 - 0.19 11.6 0.2 3.7 7.5 0.0 3.0 4 0 0 4 4 4 0 Cadherin-like Cadherin PF00028.17 EMC77635.1 - 3.5e-82 271.0 3.8 5.1e-19 68.5 0.0 5.5 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 EMC77635.1 - 2.3e-57 193.4 0.1 4.3e-57 192.5 0.1 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_3 PF16184.5 EMC77635.1 - 4.8e-07 29.8 4.5 2.2 8.3 0.0 5.7 6 0 0 6 6 6 2 Cadherin-like Cadherin_2 PF08266.12 EMC77635.1 - 0.00026 20.8 0.0 0.43 10.4 0.0 3.6 3 1 0 3 3 3 1 Cadherin-like Cadherin_pro PF08758.11 EMC77635.1 - 0.0011 19.1 0.0 0.76 10.0 0.0 3.5 3 0 0 3 3 3 1 Cadherin prodomain like ASFV_J13L PF05568.11 EMC77635.1 - 0.0059 16.4 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 African swine fever virus J13L protein Invasin_D3 PF09134.10 EMC77635.1 - 0.048 14.0 2.9 15 6.0 0.0 4.6 4 1 1 5 5 5 0 Invasin, domain 3 Big_9 PF17963.1 EMC77635.1 - 2.1 9.1 9.3 17 6.2 0.1 4.4 5 0 0 5 5 5 0 Bacterial Ig domain Cadherin_4 PF17803.1 EMC77635.1 - 2.5 8.8 15.0 3.8 8.2 0.2 4.5 5 0 0 5 5 5 0 Bacterial cadherin-like domain Trypsin PF00089.26 EMC77637.1 - 9.3e-17 61.6 0.2 1e-16 61.5 0.2 1.0 1 0 0 1 1 1 1 Trypsin cNMP_binding PF00027.29 EMC77638.1 - 1.4e-34 118.0 0.0 5.2e-16 58.5 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Patatin PF01734.22 EMC77638.1 - 7e-22 78.6 0.1 1.5e-21 77.6 0.1 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase TPP_enzyme_C PF02775.21 EMC77639.1 - 3.1e-20 72.5 0.0 4.9e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EMC77639.1 - 3e-16 59.4 0.0 5.9e-16 58.4 0.0 1.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain CBM_21 PF03370.13 EMC77640.1 - 1.3e-31 109.1 0.5 2.7e-31 108.0 0.3 1.5 2 0 0 2 2 2 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 EMC77640.1 - 8.1e-13 48.8 0.2 1.7e-12 47.7 0.2 1.4 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) Ldl_recept_a PF00057.18 EMC77641.1 - 2.1e-44 149.4 98.3 1.5e-09 37.9 9.6 6.9 7 0 0 7 7 7 6 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 EMC77641.1 - 2.9e-28 98.1 1.2 2.1e-10 40.9 0.0 5.6 5 0 0 5 5 5 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 EMC77641.1 - 1e-11 44.9 23.0 6.3e-08 32.8 7.5 7.7 5 2 2 7 7 7 3 Coagulation Factor Xa inhibitory site cEGF PF12662.7 EMC77641.1 - 7.3e-09 35.4 7.7 5.7e-06 26.1 0.5 5.0 5 0 0 5 5 5 2 Complement Clr-like EGF-like EGF_CA PF07645.15 EMC77641.1 - 7.7e-08 32.4 2.8 7.7e-08 32.4 2.8 7.6 5 2 3 8 8 8 1 Calcium-binding EGF domain PMP22_Claudin PF00822.20 EMC77642.1 - 3.6e-15 56.2 0.0 4.6e-15 55.9 0.0 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Clc-like PF07062.12 EMC77642.1 - 0.0042 16.6 0.6 0.0086 15.6 0.0 1.8 2 0 0 2 2 2 1 Clc-like L_HMGIC_fpl PF10242.9 EMC77642.1 - 0.0084 16.3 1.6 0.011 15.9 1.6 1.3 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein DUF202 PF02656.15 EMC77642.1 - 0.085 13.3 3.7 0.67 10.4 1.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF202) TMEM100 PF16311.5 EMC77642.1 - 0.2 11.2 2.4 0.61 9.7 0.5 2.1 2 0 0 2 2 2 0 Transmembrane protein 100 DUF1418 PF07214.12 EMC77642.1 - 0.38 10.6 3.8 0.21 11.5 1.5 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1418) DUF1282 PF06930.12 EMC77642.1 - 0.56 10.0 4.5 0.57 10.0 2.5 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1282) Claudin_2 PF13903.6 EMC77642.1 - 0.71 9.6 10.9 1.5 8.5 8.8 2.6 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF2892 PF11127.8 EMC77642.1 - 9.6 6.3 13.4 0.4 10.8 3.5 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2892) RnaseA PF00074.20 EMC77644.1 - 0.00014 22.3 0.1 0.00015 22.2 0.1 1.0 1 0 0 1 1 1 1 Pancreatic ribonuclease DUF5505 PF17610.2 EMC77644.1 - 0.03 14.3 0.0 0.03 14.3 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5505) Ribosomal_S3Ae PF01015.18 EMC77645.1 - 9.3e-99 329.0 6.3 1.1e-98 328.8 6.3 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.16 EMC77645.1 - 0.0053 16.3 0.1 0.024 14.2 0.0 2.2 1 1 1 2 2 2 1 Partial alpha/beta-hydrolase lipase region NLRC4_HD2 PF17776.1 EMC77645.1 - 0.0076 16.8 0.2 0.01 16.3 0.2 1.2 1 0 0 1 1 1 1 NLRC4 helical domain HD2 RAI16-like PF10257.9 EMC77647.1 - 4.6e-96 321.8 12.9 5.5e-96 321.6 12.9 1.1 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein TMEM154 PF15102.6 EMC77648.1 - 1.2e-36 125.7 2.1 1.5e-36 125.4 2.1 1.1 1 0 0 1 1 1 1 TMEM154 protein family Orf78 PF06024.12 EMC77648.1 - 6.4e-06 26.4 0.1 1.3e-05 25.4 0.1 1.4 1 0 0 1 1 1 1 Orf78 (ac78) Insulin_TMD PF17870.1 EMC77648.1 - 0.0023 17.9 1.2 0.0041 17.2 1.2 1.3 1 0 0 1 1 1 1 Insulin receptor trans-membrane segment RIFIN PF02009.16 EMC77648.1 - 0.0024 17.9 0.0 0.0037 17.2 0.0 1.2 1 0 0 1 1 1 1 Rifin CcmH PF03918.14 EMC77648.1 - 0.0028 16.9 0.0 0.0045 16.3 0.0 1.3 1 0 0 1 1 1 1 Cytochrome C biogenesis protein DUF3377 PF11857.8 EMC77648.1 - 0.0043 16.9 0.1 0.0086 16.0 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) DUF4448 PF14610.6 EMC77648.1 - 0.011 15.5 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF5305 PF17231.2 EMC77648.1 - 0.011 15.1 0.2 0.016 14.6 0.2 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5305) Glycophorin_A PF01102.18 EMC77648.1 - 0.022 15.0 0.0 0.028 14.6 0.0 1.2 1 0 0 1 1 1 0 Glycophorin A DUF4064 PF13273.6 EMC77648.1 - 0.024 14.9 0.2 0.036 14.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) COX2_TM PF02790.15 EMC77648.1 - 0.031 14.4 0.0 0.05 13.8 0.0 1.4 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane domain BatD PF13584.6 EMC77648.1 - 0.034 13.0 0.0 0.04 12.7 0.0 1.0 1 0 0 1 1 1 0 Oxygen tolerance DUF2207 PF09972.9 EMC77648.1 - 0.035 12.9 0.0 0.035 12.9 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Ac76 PF05814.11 EMC77648.1 - 0.038 14.0 0.2 0.071 13.1 0.2 1.5 1 0 0 1 1 1 0 Orf76 (Ac76) EphA2_TM PF14575.6 EMC77648.1 - 0.039 14.8 0.0 0.054 14.4 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF5385 PF17359.2 EMC77648.1 - 0.05 13.2 0.4 0.086 12.4 0.4 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5385) FeoB_associated PF12669.7 EMC77648.1 - 0.057 13.8 0.8 0.13 12.7 0.8 1.6 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Afaf PF15339.6 EMC77648.1 - 0.058 13.1 0.0 0.085 12.6 0.0 1.2 1 0 0 1 1 1 0 Acrosome formation-associated factor 7tm_1 PF00001.21 EMC77648.1 - 0.06 12.7 0.0 0.06 12.7 0.0 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) SIT PF15330.6 EMC77648.1 - 0.063 13.7 0.5 0.13 12.7 0.4 1.5 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT ECSCR PF15820.5 EMC77648.1 - 0.065 13.1 0.1 0.091 12.6 0.1 1.3 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator YajC PF02699.15 EMC77648.1 - 0.082 12.8 0.2 0.16 11.8 0.2 1.5 1 0 0 1 1 1 0 Preprotein translocase subunit RseC_MucC PF04246.12 EMC77648.1 - 0.093 12.7 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC FixS PF03597.15 EMC77648.1 - 6.7 6.5 7.6 11 5.9 7.6 1.3 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type Arfaptin PF06456.13 EMC77649.1 - 3.1e-81 272.3 9.3 4.3e-81 271.8 9.3 1.1 1 0 0 1 1 1 1 Arfaptin-like domain TPR_MLP1_2 PF07926.12 EMC77649.1 - 0.059 13.4 5.0 3.4 7.8 0.9 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein NHL PF01436.21 EMC77650.1 - 9.5e-52 170.5 19.0 8.9e-10 38.1 0.2 6.6 6 0 0 6 6 6 6 NHL repeat DUF5128 PF17170.4 EMC77650.1 - 1.9e-19 70.0 9.1 2.5e-08 33.5 0.7 4.1 2 2 1 3 3 3 3 6-bladed beta-propeller Filamin PF00630.19 EMC77650.1 - 1e-17 64.8 0.0 3.9e-17 63.0 0.0 2.0 2 0 0 2 2 1 1 Filamin/ABP280 repeat SGL PF08450.12 EMC77650.1 - 1.8e-11 44.1 3.5 0.00027 20.6 0.0 5.5 1 1 3 5 5 5 3 SMP-30/Gluconolactonase/LRE-like region zf-B_box PF00643.24 EMC77650.1 - 9.3e-11 41.7 3.3 9.3e-11 41.7 3.3 2.9 3 1 0 3 3 1 1 B-box zinc finger zf-RING_UBOX PF13445.6 EMC77650.1 - 5.9e-10 39.0 5.8 5.9e-10 39.0 5.8 2.5 2 1 1 3 3 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EMC77650.1 - 2e-08 33.9 10.0 2e-08 33.9 10.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC77650.1 - 5.1e-08 32.6 10.2 5.1e-08 32.6 10.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMC77650.1 - 1.2e-07 31.4 7.8 1.2e-07 31.4 7.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC77650.1 - 5.2e-07 29.5 8.5 5.2e-07 29.5 8.5 2.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 EMC77650.1 - 7e-07 29.5 9.6 7e-07 29.5 9.6 2.7 2 0 0 2 2 2 1 Ring finger domain DUF4934 PF16288.5 EMC77650.1 - 2.1e-06 27.6 1.7 0.054 13.4 0.4 3.4 2 1 1 3 3 3 3 Domain of unknown function (DUF4934) Prok-RING_4 PF14447.6 EMC77650.1 - 1.5e-05 24.7 8.8 1.5e-05 24.7 8.8 2.6 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EMC77650.1 - 0.0001 22.4 11.1 0.0001 22.4 11.1 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 EMC77650.1 - 0.0066 16.5 1.4 0.017 15.2 1.4 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger SBBP PF06739.11 EMC77650.1 - 0.0076 16.2 1.7 0.5 10.4 0.3 3.4 4 0 0 4 4 3 1 Beta-propeller repeat Caskin-tail PF16632.5 EMC77650.1 - 0.011 16.2 0.5 0.024 15.0 0.5 1.6 1 0 0 1 1 1 0 C-terminal region of Caskin Invasin_D3 PF09134.10 EMC77650.1 - 0.013 15.7 0.0 0.047 14.0 0.0 1.9 1 0 0 1 1 1 0 Invasin, domain 3 Ldl_recept_b PF00058.17 EMC77650.1 - 0.026 15.0 0.0 28 5.3 0.0 4.0 4 0 0 4 4 4 0 Low-density lipoprotein receptor repeat class B zf-RING_11 PF17123.5 EMC77650.1 - 0.032 14.0 3.9 0.089 12.6 3.9 1.8 1 0 0 1 1 1 0 RING-like zinc finger Cadherin_5 PF17892.1 EMC77650.1 - 0.18 11.8 0.6 0.48 10.4 0.0 2.1 2 0 0 2 2 1 0 Cadherin-like domain NPV_P10 PF05531.12 EMC77650.1 - 0.8 10.2 2.9 1.5 9.3 1.5 2.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein VCBS PF13517.6 EMC77650.1 - 2.5 8.8 8.1 27 5.5 0.0 4.4 2 1 3 5 5 5 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella zf-RING_10 PF16685.5 EMC77650.1 - 3.2 8.0 11.7 4.4 7.5 4.7 2.4 2 0 0 2 2 2 0 zinc RING finger of MSL2 Mnd1 PF03962.15 EMC77651.1 - 2e-28 98.5 0.2 2e-28 98.5 0.2 2.5 3 0 0 3 3 3 1 Mnd1 HTH domain LZ3wCH PF18517.1 EMC77651.1 - 3.8e-24 84.5 1.0 3.8e-24 84.5 1.0 2.6 3 0 0 3 3 3 1 Leucine zipper with capping helix domain DivIC PF04977.15 EMC77651.1 - 1.9e-06 27.6 10.4 0.00097 18.9 1.6 3.3 1 1 2 3 3 3 3 Septum formation initiator Penicillinase_R PF03965.16 EMC77651.1 - 4.1e-05 23.9 0.5 7.8e-05 23.0 0.2 1.6 1 1 0 1 1 1 1 Penicillinase repressor SHE3 PF17078.5 EMC77651.1 - 0.0089 15.8 7.6 0.013 15.2 7.6 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 FapA PF03961.13 EMC77651.1 - 0.041 12.5 5.8 0.061 11.9 5.8 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DsrD PF08679.11 EMC77651.1 - 0.049 13.9 1.1 0.21 11.8 0.1 2.4 2 0 0 2 2 2 0 Dissimilatory sulfite reductase D (DsrD) Prefoldin PF02996.17 EMC77651.1 - 0.095 12.6 5.0 3.8 7.4 0.2 2.5 2 1 0 2 2 2 0 Prefoldin subunit DASH_Spc19 PF08287.11 EMC77651.1 - 0.21 11.5 9.5 0.37 10.7 9.5 1.4 1 0 0 1 1 1 0 Spc19 MHB PF16525.5 EMC77651.1 - 0.25 11.6 0.8 0.5 10.7 0.2 1.7 2 0 0 2 2 2 0 Haemophore, haem-binding Atg14 PF10186.9 EMC77651.1 - 0.28 10.2 5.7 0.37 9.8 5.7 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 APG6_N PF17675.1 EMC77651.1 - 0.95 10.0 11.6 1.8 9.1 11.6 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region Spc7 PF08317.11 EMC77651.1 - 2 7.2 17.9 0.15 10.9 2.7 2.5 2 1 1 3 3 3 0 Spc7 kinetochore protein ABC_tran_CTD PF16326.5 EMC77651.1 - 3.7 7.9 13.5 2.6 8.3 10.5 2.2 1 1 1 2 2 2 0 ABC transporter C-terminal domain ZapB PF06005.12 EMC77651.1 - 4.8 7.7 14.2 4e+02 1.5 14.2 2.3 1 1 0 1 1 1 0 Cell division protein ZapB TPR_MLP1_2 PF07926.12 EMC77651.1 - 7.4 6.6 15.9 2.5 8.2 4.5 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4140 PF13600.6 EMC77651.1 - 8 7.0 7.5 28 5.2 0.3 2.3 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) TMEM131_like PF12371.8 EMC77652.1 - 1e-17 64.2 0.9 9.5e-17 61.0 0.3 2.9 3 0 0 3 3 3 1 Transmembrane protein 131-like ASH PF15780.5 EMC77652.1 - 1.9e-09 37.6 0.1 3.4e-05 24.0 0.0 4.3 4 0 0 4 4 4 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin LRR_8 PF13855.6 EMC77653.1 - 9.7e-37 124.5 42.6 4.1e-15 55.3 9.3 7.8 4 3 2 7 7 7 7 Leucine rich repeat TIR PF01582.20 EMC77653.1 - 5e-22 78.5 0.3 8.5e-22 77.8 0.3 1.4 1 0 0 1 1 1 1 TIR domain LRR_4 PF12799.7 EMC77653.1 - 9.6e-22 76.7 47.4 0.00065 20.0 5.9 9.5 7 2 2 10 10 10 7 Leucine Rich repeats (2 copies) TIR_2 PF13676.6 EMC77653.1 - 1.1e-15 58.2 0.1 5.9e-15 55.9 0.1 2.3 2 0 0 2 2 2 1 TIR domain LRR_9 PF14580.6 EMC77653.1 - 3.8e-09 36.3 11.0 0.0018 17.8 0.0 4.8 2 2 2 4 4 4 4 Leucine-rich repeat LRR_5 PF13306.6 EMC77653.1 - 7.6e-05 22.7 0.7 0.025 14.6 0.0 2.8 2 2 1 3 3 3 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EMC77653.1 - 9.4e-05 22.5 41.1 0.074 13.6 0.7 11.6 9 3 0 9 9 9 2 Leucine Rich Repeat LRR_6 PF13516.6 EMC77653.1 - 0.053 13.6 25.5 30 5.0 0.0 9.8 10 0 0 10 10 10 0 Leucine Rich repeat DUF1863 PF08937.11 EMC77653.1 - 0.063 13.6 0.2 0.39 11.0 0.2 2.3 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) Fz PF01392.22 EMC77655.1 - 1.4e-29 103.0 2.8 2.9e-29 101.9 2.8 1.5 1 0 0 1 1 1 1 Fz domain NTR PF01759.21 EMC77655.1 - 2.8e-12 46.4 0.2 4.7e-12 45.7 0.2 1.4 1 0 0 1 1 1 1 UNC-6/NTR/C345C module TBP PF00352.21 EMC77655.1 - 0.12 12.3 0.0 11 6.0 0.0 2.3 2 0 0 2 2 2 0 Transcription factor TFIID (or TATA-binding protein, TBP) Cadherin PF00028.17 EMC77656.1 - 1.1e-94 311.0 9.3 8.6e-20 71.0 0.0 6.5 7 0 0 7 7 7 6 Cadherin domain Cadherin_2 PF08266.12 EMC77656.1 - 4.2e-12 45.7 0.4 0.51 10.2 0.0 6.6 6 1 0 6 6 6 5 Cadherin-like RET_CLD1 PF17756.1 EMC77656.1 - 3.5e-05 24.1 0.3 3.6 7.9 0.0 5.2 5 1 0 5 5 5 2 RET Cadherin like domain 1 Cadherin PF00028.17 EMC77657.1 - 3.2e-11 43.5 0.0 5.5e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 Cadherin domain WD40 PF00400.32 EMC77658.1 - 1e-40 136.9 20.8 2e-09 37.9 0.6 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC77658.1 - 1.5e-05 25.2 4.6 0.25 11.7 0.1 5.0 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 EMC77658.1 - 9e-05 21.4 0.6 0.74 8.5 0.0 3.7 2 1 1 4 4 4 2 Nup133 N terminal like BBS2_Mid PF14783.6 EMC77658.1 - 0.0012 18.9 0.1 5.9 7.0 0.0 4.3 3 1 2 5 5 5 1 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 EMC77658.1 - 0.0034 16.1 4.1 0.54 8.8 0.4 3.8 1 1 3 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 EMC77658.1 - 0.061 12.7 0.0 0.28 10.4 0.0 2.1 2 1 1 3 3 3 0 WD40-like domain Fibrinogen_C PF00147.18 EMC77659.1 - 1.9e-101 338.5 14.1 2.6e-101 338.0 14.1 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fib_alpha PF08702.10 EMC77659.1 - 1.3e-41 142.1 3.7 1.7e-41 141.7 3.7 1.2 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family DUF1465 PF07323.12 EMC77659.1 - 0.0023 17.8 1.9 0.059 13.2 0.4 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF1465) DUF5082 PF16888.5 EMC77659.1 - 0.017 15.4 8.3 0.069 13.4 4.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) DUF1664 PF07889.12 EMC77659.1 - 0.15 12.1 2.1 0.35 10.9 1.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Bacillus_HBL PF05791.11 EMC77659.1 - 0.28 11.0 8.3 0.61 9.9 2.2 2.5 2 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Fibrinogen_C PF00147.18 EMC77660.1 - 1.2e-72 244.3 3.8 1.4e-72 244.1 3.8 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fib_alpha PF08702.10 EMC77661.1 - 4.5e-43 146.9 2.9 4.5e-43 146.9 2.9 2.1 2 0 0 2 2 2 1 Fibrinogen alpha/beta chain family FliD_C PF07195.12 EMC77661.1 - 0.021 14.2 2.0 0.042 13.3 2.0 1.5 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus Cu-oxidase_4 PF02578.15 EMC77661.1 - 0.026 14.1 0.4 2.1 7.9 0.0 2.1 1 1 1 2 2 2 0 Multi-copper polyphenol oxidoreductase laccase RMI1_N PF08585.12 EMC77661.1 - 0.03 14.1 0.8 0.039 13.7 0.8 1.3 1 0 0 1 1 1 0 RecQ mediated genome instability protein DUF2935 PF11155.8 EMC77661.1 - 0.031 14.6 0.5 0.031 14.6 0.5 1.9 3 0 0 3 3 3 0 Domain of unknown function (DUF2935) HCMV_UL139 PF12507.8 EMC77661.1 - 0.059 13.8 0.2 0.1 13.0 0.2 1.4 1 0 0 1 1 1 0 Human Cytomegalovirus UL139 protein DUF4407 PF14362.6 EMC77661.1 - 0.24 10.7 5.3 0.95 8.8 5.3 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 EMC77661.1 - 1.1 9.3 5.9 9.7 6.3 0.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ING PF12998.7 EMC77661.1 - 4.5 7.9 8.4 4.3 8.0 1.0 2.7 1 1 2 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding TMPIT PF07851.13 EMC77661.1 - 4.6 6.4 7.6 1.7 7.8 1.5 2.1 1 1 1 2 2 2 0 TMPIT-like protein Fibrinogen_C PF00147.18 EMC77662.1 - 3.2e-94 314.9 9.2 4.5e-94 314.4 9.2 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fib_alpha PF08702.10 EMC77662.1 - 1.1e-41 142.3 8.7 1.5e-41 141.9 8.7 1.2 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family EzrA PF06160.12 EMC77662.1 - 0.002 16.4 7.9 0.0083 14.4 7.8 1.7 1 1 1 2 2 2 2 Septation ring formation regulator, EzrA DUF2935 PF11155.8 EMC77662.1 - 0.032 14.6 2.0 0.17 12.2 1.4 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) GIT1_C PF12205.8 EMC77662.1 - 0.26 11.4 4.9 1.6 8.9 3.6 2.1 1 1 0 1 1 1 0 G protein-coupled receptor kinase-interacting protein 1 C term Lzipper-MIP1 PF14389.6 EMC77662.1 - 0.36 11.2 3.0 1.9 8.9 0.8 2.3 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 SlyX PF04102.12 EMC77662.1 - 1.7 9.3 5.1 0.5 11.0 1.5 1.9 2 0 0 2 2 2 0 SlyX AtuA PF07287.11 EMC77663.1 - 2.6e-95 319.1 0.0 3e-95 318.9 0.0 1.0 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA RRM_1 PF00076.22 EMC77664.1 - 4.4e-37 125.7 2.4 9.1e-14 51.0 0.1 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DND1_DSRM PF14709.7 EMC77664.1 - 3.3e-25 88.1 0.1 7.2e-25 87.1 0.1 1.6 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 RRM_7 PF16367.5 EMC77664.1 - 3.6e-06 27.0 2.8 0.039 14.1 0.1 4.0 2 2 1 3 3 3 2 RNA recognition motif RRM_5 PF13893.6 EMC77664.1 - 0.0036 16.9 0.0 3.3 7.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 7tm_1 PF00001.21 EMC77665.1 - 1e-54 185.6 14.3 1.3e-54 185.3 14.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC77665.1 - 5.2e-15 55.5 13.4 7.2e-15 55.1 13.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC77665.1 - 2.9e-06 27.1 8.4 2.9e-06 27.1 8.4 1.8 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC77665.1 - 4.8e-05 23.2 15.1 6.9e-05 22.7 15.1 1.2 1 0 0 1 1 1 1 Olfactory receptor DUF5409 PF17421.2 EMC77665.1 - 0.72 10.6 0.1 0.72 10.6 0.1 2.7 4 0 0 4 4 4 0 Family of unknown function (DUF5409) hNIFK_binding PF12196.8 EMC77666.1 - 0.17 11.4 1.1 0.74 9.4 1.1 2.2 1 0 0 1 1 1 0 FHA Ki67 binding domain of hNIFK DUF4207 PF13904.6 EMC77666.1 - 0.59 9.8 81.7 0.26 11.0 32.0 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4207) AF-4 PF05110.13 EMC77667.1 - 8.2e-99 332.3 29.3 4.1e-67 227.3 19.6 2.0 1 1 1 2 2 2 2 AF-4 proto-oncoprotein FXMRP1_C_core PF12235.8 EMC77668.1 - 3.5e-43 147.5 10.7 3.5e-43 147.5 10.7 2.6 1 1 1 2 2 2 1 Fragile X-related 1 protein core C terminal KH_9 PF17904.1 EMC77668.1 - 2.3e-37 127.2 1.2 5.9e-37 125.9 1.2 1.8 1 0 0 1 1 1 1 FMRP KH0 domain Tudor_FRX1 PF18336.1 EMC77668.1 - 3.8e-19 68.3 1.7 3.8e-19 68.3 1.7 2.1 2 0 0 2 2 2 1 Fragile X mental retardation Tudor domain FXMR_C2 PF16098.5 EMC77668.1 - 3.2e-17 62.8 13.9 1.4e-10 41.5 0.6 3.3 2 1 1 3 3 3 2 Fragile X-related mental retardation protein C-terminal region 2 KH_1 PF00013.29 EMC77668.1 - 4.9e-16 58.3 0.6 6.1e-08 32.4 0.8 2.6 2 0 0 2 2 2 2 KH domain Agenet PF05641.12 EMC77668.1 - 1e-08 35.5 1.2 3.5e-06 27.4 0.5 2.9 3 0 0 3 3 3 1 Agenet domain KH_2 PF07650.17 EMC77668.1 - 0.00078 19.2 0.6 0.27 11.1 0.0 2.5 2 0 0 2 2 2 2 KH domain PrgI PF12666.7 EMC77668.1 - 0.025 15.3 0.2 0.046 14.4 0.2 1.3 1 0 0 1 1 1 0 PrgI family protein KH_4 PF13083.6 EMC77668.1 - 0.056 13.3 1.6 3.1 7.7 0.3 3.3 2 1 1 3 3 3 0 KH domain FXR_C3 PF16097.5 EMC77668.1 - 2.3 9.0 7.0 1.1 10.1 1.7 2.6 2 0 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 3 HSF_DNA-bind PF00447.17 EMC77669.1 - 1.8e-10 41.3 0.0 2e-10 41.1 0.0 1.0 1 0 0 1 1 1 1 HSF-type DNA-binding LRR_8 PF13855.6 EMC77670.1 - 2.8e-50 167.9 60.3 1.3e-16 60.1 2.0 6.5 2 2 5 7 7 7 7 Leucine rich repeat LRR_5 PF13306.6 EMC77670.1 - 3.7e-18 65.7 0.0 4.9e-08 33.0 0.0 2.3 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 EMC77670.1 - 3.5e-15 55.9 49.3 1.5e-05 25.2 0.7 7.9 6 1 3 9 9 9 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC77670.1 - 2.5e-07 30.3 33.2 2.8 8.8 0.2 10.9 10 2 0 10 10 10 5 Leucine Rich Repeat LRR_9 PF14580.6 EMC77670.1 - 2.3e-05 24.0 12.2 0.37 10.3 1.4 4.1 2 2 2 4 4 4 3 Leucine-rich repeat LRRNT PF01462.18 EMC77670.1 - 0.009 15.6 1.8 0.009 15.6 1.8 2.9 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain MCLC PF05934.11 EMC77670.1 - 0.11 11.2 0.0 0.17 10.6 0.0 1.1 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) LRR_8 PF13855.6 EMC77671.1 - 3.1e-51 171.0 38.6 4.4e-16 58.4 5.1 6.6 2 2 4 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EMC77671.1 - 9.4e-23 79.9 45.3 9.9e-07 29.0 0.4 8.0 5 2 3 9 9 9 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC77671.1 - 1.6e-17 63.7 0.6 4.2e-08 33.2 1.1 2.5 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC77671.1 - 4e-09 36.2 15.0 6.2e-05 22.6 0.2 4.4 2 2 2 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 EMC77671.1 - 0.00032 20.9 37.5 0.19 12.4 0.0 10.6 10 2 0 10 10 10 2 Leucine Rich Repeat LRRNT PF01462.18 EMC77671.1 - 0.00044 19.8 3.3 0.00044 19.8 3.3 2.3 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain TPKR_C2 PF16920.5 EMC77671.1 - 0.0019 18.3 0.4 0.54 10.4 0.1 3.0 2 0 0 2 2 2 1 Tyrosine-protein kinase receptor C2 Ig-like domain SOXp PF12336.8 EMC77672.1 - 3.2e-30 105.0 1.2 3.2e-30 105.0 1.2 3.8 3 1 1 4 4 4 2 SOX transcription factor HMG_box PF00505.19 EMC77672.1 - 1.4e-28 99.1 5.8 2.2e-28 98.5 4.9 1.8 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC77672.1 - 3.4e-12 46.8 4.2 5.5e-12 46.1 4.2 1.4 1 0 0 1 1 1 1 HMG-box domain Neur_chan_memb PF02932.16 EMC77674.1 - 9e-53 179.8 0.0 1.5e-52 179.1 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 EMC77674.1 - 1.2e-37 129.4 0.1 1.7e-37 129.0 0.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_LBD PF02931.23 EMC77675.1 - 9.8e-48 162.4 0.0 1.5e-47 161.9 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC77675.1 - 1.2e-38 133.6 6.4 2.6e-31 109.5 5.9 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region CytochromB561_N PF09786.9 EMC77675.1 - 0.042 12.8 1.4 0.057 12.4 1.4 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal Neur_chan_LBD PF02931.23 EMC77676.1 - 5.5e-49 166.5 1.2 7.6e-49 166.1 1.2 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC77676.1 - 8.4e-37 127.5 9.9 1.6e-33 116.7 4.7 2.1 1 1 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Collagen PF01391.18 EMC77677.1 - 4e-27 93.7 61.7 1.8e+04 -6.3 61.7 4.0 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) RPEL PF02755.15 EMC77678.1 - 2.1e-18 65.4 6.7 9.7e-07 28.3 0.0 3.5 3 0 0 3 3 3 3 RPEL repeat SAP PF02037.27 EMC77678.1 - 7.2e-10 38.4 0.1 7.2e-10 38.4 0.1 2.3 3 0 0 3 3 3 1 SAP domain LRAT PF04970.13 EMC77679.1 - 7.7e-09 35.9 0.5 2.2e-08 34.4 0.5 1.8 1 1 0 1 1 1 1 Lecithin retinol acyltransferase NLPC_P60 PF00877.19 EMC77679.1 - 0.0068 16.4 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 NlpC/P60 family Peptidase_C97 PF05903.14 EMC77679.1 - 0.11 12.4 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 PPPDE putative peptidase domain Ribosomal_L1 PF00687.21 EMC77679.1 - 0.13 11.9 0.0 0.37 10.5 0.0 1.6 2 0 0 2 2 2 0 Ribosomal protein L1p/L10e family LRAT PF04970.13 EMC77680.1 - 5.6e-08 33.1 0.3 1e-06 29.0 0.3 2.1 1 1 0 1 1 1 1 Lecithin retinol acyltransferase Peptidase_C92 PF05708.12 EMC77680.1 - 0.029 14.5 0.0 0.035 14.2 0.0 1.2 1 0 0 1 1 1 0 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family LRAT PF04970.13 EMC77681.1 - 7.6e-09 35.9 2.8 4.4e-08 33.5 2.8 1.9 1 1 0 1 1 1 1 Lecithin retinol acyltransferase NLPC_P60 PF00877.19 EMC77681.1 - 0.02 14.9 0.1 0.061 13.4 0.0 1.8 2 0 0 2 2 2 0 NlpC/P60 family Adaptin_N PF01602.20 EMC77682.1 - 1.5e-29 103.0 0.1 1.8e-29 102.7 0.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EMC77682.1 - 0.091 12.8 0.1 0.24 11.4 0.0 1.6 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 zf-C3HC4_3 PF13920.6 EMC77683.1 - 5.2e-09 35.8 7.3 5.2e-09 35.8 7.3 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC77683.1 - 1.2e-08 34.7 9.7 4.1e-08 33.0 9.7 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC77683.1 - 1.8e-08 34.1 10.6 6e-08 32.4 10.6 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC77683.1 - 2.4e-08 34.2 10.6 2.4e-08 34.2 10.6 2.7 4 0 0 4 4 2 1 Ring finger domain zf-rbx1 PF12678.7 EMC77683.1 - 1.1e-06 28.8 10.9 1.1e-06 28.8 10.9 2.7 3 0 0 3 3 2 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EMC77683.1 - 0.00017 21.3 9.5 0.00017 21.3 9.5 2.6 2 1 1 3 3 3 2 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EMC77683.1 - 0.00028 20.9 7.3 0.00028 20.9 7.3 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMC77683.1 - 0.00041 20.3 9.6 0.00089 19.2 8.3 2.4 1 1 1 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EMC77683.1 - 0.0032 17.5 4.4 0.0032 17.5 4.4 2.9 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 EMC77683.1 - 0.051 13.8 9.2 0.17 12.1 9.2 2.0 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EMC77683.1 - 2.1 8.2 14.2 1.4 8.8 9.4 2.8 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain SAPS PF04499.15 EMC77684.1 - 3 6.5 4.2 4 6.1 4.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Sulfatase PF00884.23 EMC77685.1 - 1.8e-50 172.1 0.4 3.2e-50 171.3 0.0 1.6 2 0 0 2 2 2 1 Sulfatase Phosphodiest PF01663.22 EMC77685.1 - 2.4e-10 40.5 0.0 4.1e-05 23.4 0.0 2.3 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 EMC77685.1 - 0.007 15.0 0.0 0.045 12.4 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF229) Tmemb_185A PF10269.9 EMC77686.1 - 5.5e-61 206.4 28.0 8.5e-61 205.8 28.0 1.3 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein ASCH PF04266.14 EMC77687.1 - 0.029 14.9 0.0 0.033 14.8 0.0 1.3 1 0 0 1 1 1 0 ASCH domain TRCF PF03461.15 EMC77687.1 - 0.11 12.9 0.0 0.21 12.0 0.0 1.5 1 0 0 1 1 1 0 TRCF domain Met_10 PF02475.16 EMC77688.1 - 7.5e-28 97.6 0.0 9.8e-28 97.3 0.0 1.1 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.14 EMC77688.1 - 0.0021 17.6 0.0 0.0032 17.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain DUF3145 PF11343.8 EMC77688.1 - 0.088 12.4 0.1 0.24 11.0 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3145) Cons_hypoth95 PF03602.15 EMC77688.1 - 0.19 11.4 0.0 0.32 10.6 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 NAD_binding_6 PF08030.12 EMC77689.1 - 6e-31 107.7 0.0 1.3e-30 106.6 0.0 1.6 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EMC77689.1 - 1.5e-24 86.5 6.5 1.5e-24 86.5 6.5 1.8 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EMC77689.1 - 4.1e-22 78.3 0.0 7.5e-22 77.5 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EMC77689.1 - 0.0031 18.1 0.0 0.016 15.8 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EMC77689.1 - 0.012 16.0 0.0 0.022 15.1 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain PDGLE PF13190.6 EMC77689.1 - 0.11 12.4 0.0 0.38 10.7 0.0 1.9 2 0 0 2 2 2 0 PDGLE domain XK-related PF09815.9 EMC77690.1 - 1.7e-69 234.5 18.8 1.9e-69 234.3 18.8 1.0 1 0 0 1 1 1 1 XK-related protein NrsF PF06532.11 EMC77690.1 - 0.036 13.8 0.0 0.036 13.8 0.0 2.3 1 1 1 2 2 2 0 Negative regulator of sigma F PhoLip_ATPase_C PF16212.5 EMC77691.1 - 4.5e-74 249.3 30.3 4.5e-74 249.3 30.3 2.3 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EMC77691.1 - 4.8e-23 80.6 0.3 4.8e-23 80.6 0.3 2.4 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EMC77691.1 - 2e-11 43.8 0.0 2e-11 43.8 0.0 3.0 2 1 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 EMC77691.1 - 1.4e-10 41.1 0.0 7.8e-10 38.7 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EMC77691.1 - 4.6e-08 33.6 3.8 0.00014 22.2 3.4 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EMC77691.1 - 0.0056 16.5 0.1 0.52 10.0 0.0 3.2 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase VPS13_mid_rpt PF16910.5 EMC77691.1 - 0.094 12.1 0.4 0.18 11.2 0.4 1.4 1 0 0 1 1 1 0 Repeating coiled region of VPS13 RhoGEF PF00621.20 EMC77692.1 - 1e-35 123.7 0.4 1e-35 123.7 0.4 3.0 3 0 0 3 3 3 1 RhoGEF domain CRAL_TRIO_2 PF13716.6 EMC77692.1 - 5e-08 33.2 0.0 1.5e-07 31.6 0.0 1.9 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain PH PF00169.29 EMC77692.1 - 1.2e-06 29.0 0.2 3.4e-06 27.5 0.2 1.9 1 0 0 1 1 1 1 PH domain Spectrin PF00435.21 EMC77692.1 - 0.0086 16.6 1.2 0.0086 16.6 1.2 4.9 5 1 0 5 5 5 2 Spectrin repeat CRAL_TRIO PF00650.20 EMC77692.1 - 0.091 12.5 0.0 0.22 11.2 0.0 1.7 1 0 0 1 1 1 0 CRAL/TRIO domain PH_10 PF15411.6 EMC77692.1 - 0.11 12.8 1.1 0.22 11.8 0.0 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain Tubulin PF00091.25 EMC77693.1 - 4.1e-53 180.5 0.0 7.4e-53 179.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EMC77693.1 - 7.2e-43 145.7 0.1 1.2e-42 145.1 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EMC77693.1 - 0.0061 16.3 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 EMC77693.1 - 0.013 14.7 0.0 0.028 13.6 0.0 1.5 1 0 0 1 1 1 0 Tubulin like DUF1648 PF07853.11 EMC77694.1 - 0.64 9.7 3.4 83 3.0 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1648) VQ PF05678.14 EMC77695.1 - 2.2e-07 30.2 0.6 2.1e+02 1.5 0.0 9.6 11 0 0 11 11 11 0 VQ motif BLOC1_2 PF10046.9 EMC77695.1 - 0.00025 21.3 0.5 10 6.5 0.1 4.1 1 1 3 4 4 4 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.12 EMC77695.1 - 0.00086 19.3 0.8 1.4 9.0 0.1 2.9 1 1 2 3 3 3 3 Protein of unknown function (DUF1664) WXG100 PF06013.12 EMC77695.1 - 0.0044 17.2 0.0 67 3.8 0.0 4.0 1 1 5 6 6 6 0 Proteins of 100 residues with WXG DUF4927 PF16279.5 EMC77695.1 - 0.0048 17.9 18.3 1.8e+04 -8.1 18.3 6.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4927) RPAP1_N PF08621.10 EMC77695.1 - 0.0049 16.6 1.7 5.7e+02 0.4 0.0 7.2 8 0 0 8 8 8 0 RPAP1-like, N-terminal Mst1_SARAH PF11629.8 EMC77695.1 - 0.0058 16.7 19.9 94 3.2 0.0 8.8 4 4 5 9 9 9 0 C terminal SARAH domain of Mst1 ArgoL2 PF16488.5 EMC77695.1 - 0.32 11.4 19.1 76 3.8 0.8 7.6 4 4 1 5 5 5 0 Argonaute linker 2 domain DUF4298 PF14131.6 EMC77695.1 - 4.2 7.4 6.8 91 3.1 0.1 3.6 1 1 3 5 5 5 0 Domain of unknown function (DUF4298) Squash PF00299.18 EMC77696.1 - 0.11 12.5 0.1 0.2 11.7 0.1 1.3 1 0 0 1 1 1 0 Squash family serine protease inhibitor SEA PF01390.20 EMC77697.1 - 9e-77 254.0 5.7 7e-25 87.2 0.1 3.1 3 0 0 3 3 3 3 SEA domain DUF2205 PF10224.9 EMC77697.1 - 5.5e-06 26.3 0.0 0.38 10.8 0.0 3.3 3 0 0 3 3 3 2 Short coiled-coil protein SH3_10 PF17902.1 EMC77697.1 - 0.0034 17.4 0.0 0.89 9.7 0.0 3.0 3 0 0 3 3 3 1 SH3 domain Pkinase_Tyr PF07714.17 EMC77698.1 - 7.9e-92 307.2 1.4 1.1e-91 306.8 1.4 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC77698.1 - 4.4e-48 163.9 0.4 6.6e-48 163.4 0.4 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 EMC77698.1 - 1.8e-41 140.1 0.3 5.2e-22 77.7 0.1 2.6 2 0 0 2 2 2 2 SH2 domain Haspin_kinase PF12330.8 EMC77698.1 - 0.00018 20.6 0.2 0.0004 19.4 0.2 1.6 1 1 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 EMC77698.1 - 0.0011 18.7 2.3 0.0018 17.9 2.3 1.2 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 EMC77698.1 - 0.019 14.3 0.1 0.033 13.5 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family GrlR PF16518.5 EMC77698.1 - 0.093 12.7 0.0 0.28 11.2 0.0 1.8 1 0 0 1 1 1 0 T3SS negative regulator,GrlR Pep_M12B_propep PF01562.19 EMC77699.1 - 4e-37 127.6 0.1 6.1e-37 127.0 0.1 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_spacer1 PF05986.14 EMC77699.1 - 4.2e-35 120.2 0.0 6.6e-35 119.6 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Reprolysin PF01421.19 EMC77699.1 - 7.1e-24 84.8 0.3 2.1e-23 83.3 0.3 1.9 1 1 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR_2 PF17771.1 EMC77699.1 - 1.5e-17 63.8 9.1 1.5e-17 63.8 9.1 5.9 6 1 1 7 7 3 2 ADAM cysteine-rich domain TSP_1 PF00090.19 EMC77699.1 - 8.3e-17 61.1 87.9 2.6e-06 27.5 8.8 8.0 8 1 0 8 8 8 5 Thrombospondin type 1 domain Reprolysin_5 PF13688.6 EMC77699.1 - 4.5e-13 49.8 0.1 1e-12 48.7 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EMC77699.1 - 9.5e-12 45.5 0.0 1.6e-11 44.8 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EMC77699.1 - 4.9e-11 42.9 0.2 9.5e-11 42.0 0.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like PLAC PF08686.11 EMC77699.1 - 3.4e-09 37.3 11.6 1.6e-08 35.1 11.6 2.4 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain Reprolysin_4 PF13583.6 EMC77699.1 - 1.6e-06 28.0 0.4 3.5e-06 26.8 0.4 1.6 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.8 EMC77699.1 - 0.0089 15.7 0.3 0.019 14.6 0.3 1.5 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase DUF4953 PF16313.5 EMC77699.1 - 0.066 12.4 0.2 0.1 11.8 0.2 1.2 1 0 0 1 1 1 0 Met-zincin zf-H2C2_5 PF13909.6 EMC77700.1 - 1.5e-05 24.7 1.0 2.3e-05 24.1 0.7 1.5 2 0 0 2 2 2 1 C2H2-type zinc-finger domain zf_C2H2_ZHX PF18387.1 EMC77700.1 - 0.016 14.8 0.2 0.035 13.8 0.1 1.6 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2 PF00096.26 EMC77700.1 - 0.021 15.3 0.2 0.034 14.6 0.2 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC77700.1 - 0.18 12.3 1.1 0.31 11.6 0.1 1.9 2 0 0 2 2 2 0 Zinc-finger double domain LRR_9 PF14580.6 EMC77701.1 - 1.5e-16 60.4 1.5 2e-16 60.0 1.5 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EMC77701.1 - 2.8e-14 53.0 19.7 3e-08 33.8 3.5 3.6 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EMC77701.1 - 2e-07 30.5 6.0 0.015 15.3 0.2 3.9 4 0 0 4 4 4 3 Leucine Rich repeat LRR_8 PF13855.6 EMC77701.1 - 3.7e-07 29.8 6.1 3.7e-07 29.8 6.1 3.3 2 1 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 EMC77701.1 - 5.5e-05 23.2 9.4 1 10.1 0.4 4.6 4 0 0 4 4 4 3 Leucine Rich Repeat SDA1 PF05285.12 EMC77701.1 - 0.27 10.6 28.6 0.37 10.2 28.6 1.3 1 0 0 1 1 1 0 SDA1 Ceramidase PF05875.12 EMC77702.1 - 1.7e-55 188.3 15.6 1.8e-55 188.2 15.6 1.0 1 0 0 1 1 1 1 Ceramidase AMP-binding PF00501.28 EMC77703.1 - 2.8e-88 296.3 0.0 3.5e-88 296.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Cas_Cas2CT1978 PF09707.10 EMC77703.1 - 0.052 13.6 0.0 0.18 11.9 0.0 1.9 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas2CT1978) RRM_1 PF00076.22 EMC77704.1 - 0.0023 17.7 0.0 0.47 10.3 0.0 2.2 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.6 EMC77705.1 - 1.4e-12 47.3 8.9 1.7e-12 47.0 8.9 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC77705.1 - 2e-10 40.4 8.2 2.7e-10 39.9 8.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC77705.1 - 2e-10 40.8 10.9 3.3e-10 40.1 11.0 1.4 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC77705.1 - 2.5e-10 40.0 9.1 3.4e-10 39.6 9.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMC77705.1 - 3.1e-09 37.0 8.5 5.7e-09 36.1 8.5 1.4 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EMC77705.1 - 8.9e-08 31.9 10.5 2.2e-06 27.4 11.1 2.1 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EMC77705.1 - 1.6e-07 31.3 5.6 1.7e-07 31.1 3.6 1.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMC77705.1 - 1.4e-06 28.1 9.6 4.2e-06 26.6 9.7 1.7 1 1 1 2 2 2 2 zinc-RING finger domain zf-ANAPC11 PF12861.7 EMC77705.1 - 1.5e-06 28.2 4.1 2.1e-06 27.7 4.1 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 EMC77705.1 - 1.7e-05 24.9 5.7 5.8e-05 23.2 6.0 1.8 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EMC77705.1 - 0.0012 18.6 12.8 0.0041 16.9 5.1 2.1 1 1 1 2 2 2 2 RING/Ubox like zinc-binding domain zf-IS66 PF13005.7 EMC77705.1 - 0.0025 18.2 0.3 0.16 12.4 0.0 2.4 2 0 0 2 2 2 1 zinc-finger binding domain of transposase IS66 zf-RING_10 PF16685.5 EMC77705.1 - 0.032 14.3 6.2 0.069 13.3 6.2 1.6 1 1 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_6 PF14835.6 EMC77705.1 - 0.041 13.7 1.7 0.061 13.2 1.7 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Rad50_zn_hook PF04423.14 EMC77705.1 - 0.043 13.6 0.8 6.5 6.7 0.0 2.2 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-C3HC4_5 PF17121.5 EMC77705.1 - 0.052 13.4 7.9 0.4 10.6 8.0 2.2 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF1644 PF07800.12 EMC77705.1 - 0.068 13.2 3.3 4.8 7.2 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1644) zf-Di19 PF05605.12 EMC77705.1 - 0.15 12.3 5.7 0.98 9.8 5.7 1.9 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-Nse PF11789.8 EMC77705.1 - 0.21 11.4 4.5 0.34 10.8 4.5 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zinc-ribbons_6 PF07191.12 EMC77705.1 - 0.68 9.9 8.8 2.8 8.0 8.3 1.9 1 1 0 1 1 1 0 zinc-ribbons DUF5318 PF17249.2 EMC77705.1 - 0.71 9.7 4.6 2.6 7.8 0.4 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5318) zf-RING_11 PF17123.5 EMC77705.1 - 0.79 9.5 8.4 0.57 10.0 4.5 2.4 2 1 0 2 2 2 0 RING-like zinc finger YdjO PF14169.6 EMC77705.1 - 0.88 9.3 9.4 3 7.6 3.9 2.4 1 1 1 2 2 2 0 Cold-inducible protein YdjO Zn-ribbon_8 PF09723.10 EMC77705.1 - 0.98 9.6 7.2 9.6 6.4 2.2 2.4 2 1 0 2 2 2 0 Zinc ribbon domain PAP2 PF01569.21 EMC77706.1 - 2.2e-20 72.8 1.4 4.3e-20 71.9 1.4 1.5 1 0 0 1 1 1 1 PAP2 superfamily Ribosomal_L50 PF10501.9 EMC77707.1 - 1.5e-10 41.1 0.0 2.3e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal subunit 39S zf-C3HC4_3 PF13920.6 EMC77709.1 - 1.3e-06 28.2 11.6 2.2e-06 27.4 11.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC77709.1 - 7.2e-05 22.6 14.6 0.00013 21.7 14.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC77709.1 - 0.00022 21.0 14.6 0.0004 20.2 14.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC77709.1 - 0.00033 20.5 13.6 0.0016 18.4 14.0 1.9 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 EMC77709.1 - 0.0016 18.7 13.3 0.0028 17.9 13.3 1.4 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EMC77709.1 - 0.0081 16.0 9.2 0.015 15.1 9.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EMC77709.1 - 0.012 15.8 8.0 0.028 14.7 8.0 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain DUF4407 PF14362.6 EMC77709.1 - 0.015 14.7 0.6 0.015 14.7 0.6 6.3 3 1 2 5 5 3 0 Domain of unknown function (DUF4407) zf-RING_UBOX PF13445.6 EMC77709.1 - 0.019 15.0 10.4 0.039 14.0 10.4 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 EMC77709.1 - 0.6 10.2 4.8 1.1 9.4 4.8 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 EMC77709.1 - 1.7 8.9 10.0 4.8 7.4 10.1 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING NAPRTase_N PF17767.1 EMC77709.1 - 7.5 7.0 11.1 7.2 7.0 0.3 4.5 4 1 0 4 4 4 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain Yae1_N PF09811.9 EMC77710.1 - 5.2e-11 42.1 47.6 1.8e+04 -13.3 47.6 4.7 1 1 0 1 1 1 0 Essential protein Yae1, N terminal zf-C3HC4_3 PF13920.6 EMC77711.1 - 4.3e-11 42.5 8.6 4.3e-11 42.5 8.6 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC77711.1 - 6e-10 38.8 9.4 2.3e-09 37.0 9.4 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC77711.1 - 1.4e-09 37.7 8.3 1.4e-09 37.7 8.3 2.4 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC77711.1 - 1.5e-08 34.9 10.5 1.5e-08 34.9 10.5 3.0 1 1 1 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 EMC77711.1 - 2.1e-07 31.1 9.1 2.1e-07 31.1 9.1 2.7 2 0 0 2 2 2 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EMC77711.1 - 2.9e-06 27.0 10.9 5.4e-05 23.0 10.7 2.6 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EMC77711.1 - 1.6e-05 24.9 3.1 1.6e-05 24.9 3.1 2.5 2 1 0 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EMC77711.1 - 0.00038 20.5 6.7 0.00038 20.5 6.7 2.0 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 EMC77711.1 - 0.00089 19.2 3.5 0.00089 19.2 3.5 3.0 2 1 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EMC77711.1 - 0.0029 17.7 8.0 0.0029 17.7 8.0 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EMC77711.1 - 0.0084 15.9 12.4 1.9 8.3 11.1 2.9 1 1 1 2 2 2 2 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 EMC77713.1 - 3.1e-10 39.7 6.6 3.1e-10 39.7 6.6 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC77713.1 - 1e-08 35.4 10.6 1e-08 35.4 10.6 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EMC77713.1 - 1.8e-08 34.1 8.3 1.8e-08 34.1 8.3 2.3 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMC77713.1 - 7.4e-08 32.6 8.7 7.4e-08 32.6 8.7 2.5 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EMC77713.1 - 2.5e-07 30.4 8.8 2.5e-07 30.4 8.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC77713.1 - 6.3e-05 22.8 4.8 6.3e-05 22.8 4.8 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EMC77713.1 - 0.00019 21.4 4.4 0.00058 19.9 4.4 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EMC77713.1 - 0.0021 18.0 7.7 0.0064 16.5 7.7 1.9 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EMC77713.1 - 0.024 14.5 12.2 0.024 14.5 12.2 2.9 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 EMC77713.1 - 0.039 14.1 1.7 0.039 14.1 1.7 2.3 2 0 0 2 2 2 0 zinc RING finger of MSL2 Rad50_zn_hook PF04423.14 EMC77713.1 - 0.065 13.1 1.5 0.54 10.1 0.1 2.7 3 0 0 3 3 3 0 Rad50 zinc hook motif zf-RING_4 PF14570.6 EMC77713.1 - 0.42 10.4 10.3 3.3 7.6 10.7 2.2 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Presenilin PF01080.17 EMC77713.1 - 0.43 9.3 1.1 0.6 8.8 1.1 1.1 1 0 0 1 1 1 0 Presenilin zf-MIZ PF02891.20 EMC77713.1 - 0.46 10.3 8.5 0.41 10.4 0.3 2.6 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger Apt1 PF10351.9 EMC77713.1 - 0.73 8.6 10.9 0.95 8.2 10.9 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain GEMIN8 PF15348.6 EMC77714.1 - 6.5e-92 308.0 18.7 7.3e-92 307.9 18.7 1.0 1 0 0 1 1 1 1 Gemini of Cajal bodies-associated protein 8 Myelin_PLP PF01275.19 EMC77715.1 - 6.5e-100 333.9 18.6 7.4e-100 333.7 18.6 1.0 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) PspB PF06667.12 EMC77715.1 - 0.057 13.5 0.1 0.13 12.3 0.1 1.6 1 0 0 1 1 1 0 Phage shock protein B LapA_dom PF06305.11 EMC77715.1 - 0.087 12.7 1.4 0.29 11.0 0.0 2.4 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Saf_2TM PF18303.1 EMC77715.1 - 0.2 11.2 3.4 0.56 9.8 0.7 2.6 3 0 0 3 3 3 0 SAVED-fused 2TM effector domain LisH_2 PF16045.5 EMC77716.1 - 4.9e-15 54.3 0.4 1.2e-14 53.0 0.4 1.7 1 0 0 1 1 1 1 LisH LisH PF08513.11 EMC77716.1 - 0.002 18.0 0.0 0.0059 16.5 0.0 1.9 1 0 0 1 1 1 1 LisH FOP_dimer PF09398.10 EMC77716.1 - 0.014 15.6 3.9 1 9.6 0.0 4.3 4 0 0 4 4 4 0 FOP N terminal dimerisation domain Sedlin_N PF04628.13 EMC77717.1 - 1.4e-46 157.9 0.6 1.6e-46 157.7 0.6 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 EMC77717.1 - 9.3e-09 35.3 0.2 1.2e-08 35.0 0.2 1.3 1 0 0 1 1 1 1 Sybindin-like family Flavi_M PF01004.19 EMC77717.1 - 0.016 14.9 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 Flavivirus envelope glycoprotein M Ras PF00071.22 EMC77718.1 - 3.3e-57 192.6 0.0 3.8e-57 192.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC77718.1 - 4.1e-30 104.5 0.0 6.5e-30 103.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC77718.1 - 1.2e-11 44.4 0.0 1.4e-11 44.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC77718.1 - 6.4e-06 26.2 0.0 1e-05 25.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC77718.1 - 6.7e-05 22.9 0.0 0.011 15.6 0.1 2.3 2 1 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 EMC77718.1 - 0.00015 21.2 0.0 0.00018 20.9 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 EMC77718.1 - 0.0051 16.6 0.2 0.028 14.2 0.0 1.9 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 EMC77718.1 - 0.0085 15.8 0.0 1.1 9.0 0.0 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 EMC77718.1 - 0.02 14.4 0.0 0.032 13.7 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 EMC77718.1 - 0.022 15.1 0.0 0.031 14.7 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 EMC77718.1 - 0.025 13.7 2.2 0.76 8.9 0.1 2.5 1 1 1 2 2 2 0 G-protein alpha subunit GTP_EFTU PF00009.27 EMC77718.1 - 0.029 13.9 0.0 0.091 12.3 0.0 1.8 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EMC77718.1 - 0.19 11.3 0.0 0.22 11.0 0.0 1.4 1 1 0 1 1 1 0 Ferrous iron transport protein B TFIIS_M PF07500.14 EMC77719.1 - 1.3e-28 99.7 2.7 1.3e-28 99.7 2.7 2.1 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain Med26 PF08711.11 EMC77719.1 - 6.3e-10 38.9 0.4 6.3e-10 38.9 0.4 2.3 3 0 0 3 3 3 1 TFIIS helical bundle-like domain TFIIS_C PF01096.18 EMC77719.1 - 0.0085 15.9 5.6 0.0088 15.9 0.2 2.7 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) MutS_III PF05192.18 EMC77719.1 - 0.095 12.9 6.6 0.2 11.9 6.5 1.7 1 1 0 1 1 1 0 MutS domain III Ribosomal_L37e PF01907.19 EMC77719.1 - 0.34 11.1 3.8 3 8.1 0.3 2.6 2 0 0 2 2 2 0 Ribosomal protein L37e MADF_DNA_bdg PF10545.9 EMC77719.1 - 0.73 10.2 6.0 2.2 8.6 0.2 3.1 2 1 1 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like MAM PF00629.23 EMC77720.1 - 1.8e-21 76.7 0.0 4.5e-21 75.4 0.0 1.5 1 1 0 1 1 1 1 MAM domain, meprin/A5/mu zf-C3HC4_3 PF13920.6 EMC77721.1 - 8.2e-10 38.4 7.3 1.7e-09 37.4 7.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC77721.1 - 2.6e-09 37.3 10.6 7.8e-09 35.7 10.6 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EMC77721.1 - 5.2e-09 35.8 9.7 1.4e-08 34.5 9.7 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC77721.1 - 8.2e-09 35.2 10.6 2e-08 33.9 10.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMC77721.1 - 4.3e-08 33.3 8.9 1.3e-07 31.8 8.9 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EMC77721.1 - 1.2e-05 25.0 10.0 7e-05 22.6 9.8 2.3 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EMC77721.1 - 4.7e-05 23.3 8.0 0.00015 21.7 8.0 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMC77721.1 - 7.3e-05 22.6 7.8 0.0002 21.3 7.8 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EMC77721.1 - 0.00089 19.3 4.7 0.0019 18.2 4.7 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 EMC77721.1 - 0.0033 17.5 6.8 0.01 16.0 6.8 1.9 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING MRI PF15325.6 EMC77721.1 - 0.0067 17.5 0.6 0.0067 17.5 0.6 3.2 3 0 0 3 3 3 1 Modulator of retrovirus infection zf-RING_4 PF14570.6 EMC77721.1 - 0.08 12.7 9.7 0.42 10.4 9.2 2.3 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 EMC77721.1 - 0.11 12.6 3.4 0.33 11.1 3.4 1.9 1 0 0 1 1 1 0 zinc RING finger of MSL2 Mig-14 PF07395.11 EMC77721.1 - 0.2 11.0 0.0 0.32 10.3 0.0 1.2 1 0 0 1 1 1 0 Mig-14 RINGv PF12906.7 EMC77721.1 - 1.2 9.3 6.5 4.6 7.4 6.5 2.0 1 1 0 1 1 1 0 RING-variant domain Keratin PF02422.16 EMC77722.1 - 9.4e-41 137.4 13.9 1.1e-40 137.3 13.9 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC77723.1 - 8.2e-41 137.6 13.7 9.4e-41 137.4 13.7 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC77726.1 - 1.9e-30 104.4 15.1 2.1e-30 104.2 15.1 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC77728.1 - 5.3e-39 131.8 14.4 6e-39 131.6 14.4 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC77729.1 - 3.8e-40 135.5 13.7 4.3e-40 135.3 13.7 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC77730.1 - 4.1e-41 138.6 12.8 4.7e-41 138.4 12.8 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC77732.1 - 2.4e-40 136.1 13.9 2.8e-40 135.9 13.9 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC77733.1 - 9.5e-42 140.6 12.6 1.1e-41 140.5 12.6 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC77735.1 - 1.7e-41 139.8 12.0 1.9e-41 139.6 12.0 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC77736.1 - 7.4e-41 137.8 12.6 8.4e-41 137.6 12.6 1.0 1 0 0 1 1 1 1 Keratin GTP_EFTU PF00009.27 EMC77737.1 - 2.1e-60 203.6 0.1 1.1e-59 201.3 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EMC77737.1 - 6.4e-18 64.6 0.0 1.9e-17 63.0 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EMC77737.1 - 4.4e-09 36.6 0.0 1.5e-08 34.9 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EMC77737.1 - 1.2e-08 34.9 0.2 3.8e-08 33.3 0.0 2.0 2 0 0 2 2 2 1 Elongation Factor G, domain II EFG_IV PF03764.18 EMC77737.1 - 0.0072 16.1 0.1 0.089 12.6 0.0 2.7 2 0 0 2 2 2 1 Elongation factor G, domain IV MMR_HSR1 PF01926.23 EMC77737.1 - 0.0083 16.2 0.0 0.035 14.2 0.0 2.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 EMC77737.1 - 0.062 12.5 0.7 3.5 6.7 0.0 3.1 3 0 0 3 3 3 0 G-protein alpha subunit SSXT PF05030.12 EMC77737.1 - 0.066 12.9 1.0 0.18 11.5 1.0 1.8 1 0 0 1 1 1 0 SSXT protein (N-terminal region) TMC PF07810.13 EMC77739.1 - 1.6e-40 138.1 2.2 1.6e-40 138.1 2.2 2.6 3 0 0 3 3 3 1 TMC domain Orf78 PF06024.12 EMC77739.1 - 0.4 11.0 7.9 0.26 11.6 0.2 3.9 3 0 0 3 3 3 0 Orf78 (ac78) START PF01852.19 EMC77740.1 - 8.5e-19 67.8 0.0 1.1e-18 67.5 0.0 1.0 1 0 0 1 1 1 1 START domain DUF3074 PF11274.8 EMC77740.1 - 0.12 12.4 0.0 5 7.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3074) PDZ PF00595.24 EMC77741.1 - 5.8e-24 84.2 1.6 2.4e-13 50.2 0.4 2.7 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 EMC77741.1 - 5.7e-12 45.3 0.2 1.3e-08 34.5 0.1 2.6 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 EMC77741.1 - 8.4e-07 29.2 5.5 0.00043 20.6 0.2 3.2 3 1 0 3 3 3 2 PDZ domain Mesd PF10185.9 EMC77744.1 - 7.2e-67 224.2 0.3 8.7e-67 223.9 0.3 1.2 1 0 0 1 1 1 1 Chaperone for wingless signalling and trafficking of LDL receptor DUF3391 PF11871.8 EMC77744.1 - 0.028 15.0 0.3 0.039 14.5 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) PSII_BNR PF14870.6 EMC77744.1 - 0.029 13.6 0.0 0.071 12.4 0.0 1.6 1 1 1 2 2 2 0 Photosynthesis system II assembly factor YCF48 ILEI PF15711.5 EMC77745.1 - 8.5e-14 51.8 0.1 1.9e-13 50.7 0.1 1.6 1 0 0 1 1 1 1 Interleukin-like EMT inducer Beta_helix PF13229.6 EMC77745.1 - 0.0088 15.9 2.1 0.54 10.1 1.0 3.4 2 1 1 3 3 3 2 Right handed beta helix region Swi5 PF07061.11 EMC77746.1 - 3.4e-22 78.3 0.5 3.6e-22 78.2 0.5 1.0 1 0 0 1 1 1 1 Swi5 DUF5398 PF17376.2 EMC77746.1 - 0.063 13.9 0.2 0.078 13.6 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5398) GOLGA2L5 PF15070.6 EMC77747.1 - 2.4e-282 938.2 83.0 2.4e-282 938.2 83.0 2.3 2 0 0 2 2 2 1 Putative golgin subfamily A member 2-like protein 5 DivIVA PF05103.13 EMC77747.1 - 0.0083 16.2 3.4 0.0083 16.2 3.4 10.5 2 1 8 10 10 10 1 DivIVA protein GIT_CC PF16559.5 EMC77747.1 - 0.35 10.8 0.0 0.35 10.8 0.0 12.0 9 3 2 11 11 11 0 GIT coiled-coil Rho guanine nucleotide exchange factor Dynamin_M PF01031.20 EMC77748.1 - 1.4e-110 369.0 5.0 1.4e-110 369.0 5.0 1.8 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 EMC77748.1 - 7e-42 143.3 0.1 2.6e-41 141.5 0.0 2.1 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 EMC77748.1 - 8.6e-29 99.5 2.6 2.6e-28 98.0 2.6 1.9 1 0 0 1 1 1 1 Dynamin GTPase effector domain PH PF00169.29 EMC77748.1 - 2.4e-12 47.3 0.7 5e-12 46.3 0.7 1.5 1 0 0 1 1 1 1 PH domain Ldh_1_N PF00056.23 EMC77748.1 - 0.092 12.8 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain PH_11 PF15413.6 EMC77748.1 - 0.29 11.6 3.5 1.2 9.6 1.7 2.8 2 1 0 2 2 2 0 Pleckstrin homology domain zf-C2H2_jaz PF12171.8 EMC77749.1 - 2.3e-05 24.6 26.6 8.5e-05 22.7 0.5 4.4 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC77749.1 - 0.0016 18.7 29.3 0.0025 18.1 7.2 4.4 4 0 0 4 4 4 3 Zinc-finger of C2H2 type AKAP95 PF04988.12 EMC77749.1 - 0.0047 17.2 8.4 0.0047 17.2 8.4 2.1 2 0 0 2 2 2 1 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_2 PF12756.7 EMC77749.1 - 0.039 14.3 1.6 0.039 14.3 1.6 3.8 2 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EMC77749.1 - 0.055 14.3 1.1 0.055 14.3 1.1 4.4 4 0 0 4 4 4 0 C2H2-type zinc finger THAP PF05485.12 EMC77749.1 - 2 9.4 10.7 0.25 12.3 6.0 2.0 2 0 0 2 2 2 0 THAP domain TFIIA PF03153.13 EMC77749.1 - 7.1 6.5 9.2 0.72 9.8 1.2 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit UPF0184 PF03670.13 EMC77750.1 - 8.7e-26 90.1 1.8 9.8e-26 90.0 1.8 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0184) NYD-SP28 PF14772.6 EMC77750.1 - 0.0027 17.7 2.7 0.0034 17.4 2.7 1.1 1 0 0 1 1 1 1 Sperm tail PhaP_Bmeg PF09602.10 EMC77750.1 - 0.0039 17.2 0.8 0.0042 17.0 0.8 1.0 1 0 0 1 1 1 1 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) EzrA PF06160.12 EMC77750.1 - 0.0046 15.2 1.1 0.005 15.1 1.1 1.0 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA ATP-synt_D PF01813.17 EMC77750.1 - 0.071 12.9 0.3 0.075 12.8 0.3 1.0 1 0 0 1 1 1 0 ATP synthase subunit D GST_N_3 PF13417.6 EMC77751.1 - 2.9e-12 46.8 0.5 1.7e-11 44.4 0.1 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 EMC77751.1 - 3.3e-10 40.0 0.1 7.8e-10 38.8 0.1 1.6 1 0 0 1 1 1 1 Glutaredoxin GST_N_2 PF13409.6 EMC77751.1 - 3.9e-09 36.7 0.1 1.7e-08 34.6 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EMC77751.1 - 1.8e-06 27.9 0.0 3.5e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EMC77751.1 - 0.00011 22.9 0.0 0.00025 21.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_N PF02798.20 EMC77751.1 - 0.00046 20.5 0.0 0.001 19.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EMC77751.1 - 0.0015 18.7 0.0 0.003 17.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EMC77751.1 - 0.0043 17.2 0.0 0.01 16.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain SNARE_assoc PF09335.11 EMC77751.1 - 0.048 14.1 0.0 0.086 13.3 0.0 1.4 1 0 0 1 1 1 0 SNARE associated Golgi protein Urocanase PF01175.18 EMC77751.1 - 0.068 12.8 0.0 0.37 10.4 0.0 2.0 2 0 0 2 2 2 0 Urocanase Rossmann-like domain TMF_TATA_bd PF12325.8 EMC77752.1 - 0.002 18.3 16.4 0.002 18.3 16.4 8.3 1 1 4 7 7 7 3 TATA element modulatory factor 1 TATA binding HIP1_clath_bdg PF16515.5 EMC77752.1 - 0.014 16.0 11.0 0.014 16.0 11.0 9.5 1 1 8 11 11 11 0 Clathrin-binding domain of Huntingtin-interacting protein 1 GLE1 PF07817.13 EMC77753.1 - 9.8e-90 300.1 0.0 1.9e-89 299.2 0.0 1.5 1 0 0 1 1 1 1 GLE1-like protein DUF4004 PF13171.6 EMC77753.1 - 0.42 10.8 10.7 0.55 10.4 3.3 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF4004) DUF2228 PF10228.9 EMC77753.1 - 6.9 6.3 16.4 0.4 10.4 3.5 2.4 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2228) WD40 PF00400.32 EMC77754.1 - 1e-10 42.0 12.0 1.4 9.9 0.0 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC77754.1 - 9.9e-05 22.6 0.0 15 6.0 0.0 4.6 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Imm71 PF15602.6 EMC77754.1 - 0.1 12.6 0.1 0.17 12.0 0.1 1.2 1 0 0 1 1 1 0 Immunity protein 71 NAP PF00956.18 EMC77755.1 - 1.3e-37 129.5 14.4 9.1e-34 116.9 5.3 3.1 2 1 1 3 3 3 2 Nucleosome assembly protein (NAP) Phage_Mu_Gam PF07352.12 EMC77755.1 - 0.0032 17.4 2.6 0.0069 16.3 2.6 1.6 1 0 0 1 1 1 1 Bacteriophage Mu Gam like protein Mst1_SARAH PF11629.8 EMC77755.1 - 0.064 13.4 0.8 0.17 12.0 0.8 1.7 1 0 0 1 1 1 0 C terminal SARAH domain of Mst1 ZapB PF06005.12 EMC77755.1 - 2 8.9 9.9 0.12 12.9 4.4 1.8 2 0 0 2 2 2 0 Cell division protein ZapB Nore1-SARAH PF16517.5 EMC77755.1 - 3.7 7.5 8.6 0.13 12.2 1.3 2.5 2 0 0 2 2 2 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Pkinase PF00069.25 EMC77756.1 - 8.1e-63 212.3 0.0 2e-62 211.0 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain HR1 PF02185.16 EMC77756.1 - 2.6e-46 155.6 27.8 6.5e-16 58.2 1.8 3.3 3 0 0 3 3 3 3 Hr1 repeat Pkinase_Tyr PF07714.17 EMC77756.1 - 1.3e-34 119.7 0.0 2.5e-34 118.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EMC77756.1 - 4.9e-09 36.7 1.6 1.2e-08 35.6 1.6 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Uds1 PF15456.6 EMC77756.1 - 7.1e-07 29.5 18.7 0.00054 20.1 1.2 3.4 3 0 0 3 3 3 3 Up-regulated During Septation Kinase-like PF14531.6 EMC77756.1 - 6.8e-06 25.6 0.0 1.8e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 Kinase-like PL48 PF15903.5 EMC77756.1 - 0.0047 16.0 3.4 0.29 10.1 0.5 2.4 2 0 0 2 2 2 2 Filopodia upregulated, FAM65 DUF2564 PF10819.8 EMC77756.1 - 1.6 9.2 5.0 2.3 8.7 2.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2564) DHHC PF01529.20 EMC77757.1 - 5.1e-31 107.6 16.7 5.1e-31 107.6 16.7 1.7 2 0 0 2 2 2 1 DHHC palmitoyltransferase UL42 PF17638.2 EMC77757.1 - 0.23 11.4 1.9 0.46 10.5 1.9 1.5 1 0 0 1 1 1 0 HCMV UL42 DUF3974 PF13120.6 EMC77757.1 - 0.97 9.5 4.0 0.48 10.5 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3974) Ac76 PF05814.11 EMC77757.1 - 2.5 8.2 6.6 0.16 12.0 0.5 2.1 3 0 0 3 3 3 0 Orf76 (Ac76) Baculo_11_kDa PF06143.11 EMC77757.1 - 4.2 7.0 9.1 0.13 11.9 1.8 2.1 2 0 0 2 2 2 0 Baculovirus 11 kDa family Arm PF00514.23 EMC77758.1 - 1.4e-09 37.6 0.2 1.7 8.8 0.0 6.7 7 0 0 7 7 7 2 Armadillo/beta-catenin-like repeat DUF3361 PF11841.8 EMC77758.1 - 0.009 16.0 2.1 2.3 8.1 0.8 3.4 3 1 0 3 3 3 1 Domain of unknown function (DUF3361) zf-CCCH_6 PF18585.1 EMC77758.1 - 0.0098 15.8 0.2 2.5 8.1 0.0 3.9 3 0 0 3 3 3 1 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 HEAT_EZ PF13513.6 EMC77758.1 - 0.02 15.4 0.0 0.14 12.7 0.0 2.6 3 0 0 3 3 3 0 HEAT-like repeat CC190 PF15768.5 EMC77758.1 - 0.041 14.0 0.0 0.069 13.2 0.0 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 190 SWC7 PF17330.2 EMC77758.1 - 0.05 13.7 0.6 0.24 11.5 0.1 2.4 2 0 0 2 2 2 0 SWR1 chromatin-remodelling complex, sub-unit Swc7 Lentiviral_Tat PF02998.14 EMC77758.1 - 0.15 12.1 0.3 0.5 10.4 0.3 1.9 1 0 0 1 1 1 0 Lentiviral Tat protein LRR_8 PF13855.6 EMC77758.1 - 0.16 11.8 8.7 4.5 7.1 0.2 4.0 4 0 0 4 4 4 0 Leucine rich repeat LRR_4 PF12799.7 EMC77758.1 - 0.28 11.7 12.7 2.1 8.9 0.8 5.0 2 2 4 6 6 6 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC77758.1 - 0.29 11.8 6.1 40 5.3 0.1 5.7 5 0 0 5 5 5 0 Leucine Rich Repeat RabGAP-TBC PF00566.18 EMC77759.1 - 2.8e-36 125.2 8.0 9.5e-34 116.9 2.5 2.7 2 1 0 2 2 2 2 Rab-GTPase-TBC domain TFIID_20kDa PF03847.13 EMC77759.1 - 0.025 15.1 0.5 0.064 13.8 0.1 2.0 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A Methyltrn_RNA_3 PF02598.17 EMC77760.1 - 2.1e-108 362.2 0.0 2.7e-108 361.9 0.0 1.1 1 0 0 1 1 1 1 Putative RNA methyltransferase SpoU_methylase PF00588.19 EMC77760.1 - 0.2 11.8 0.0 2.9 8.1 0.0 2.3 2 0 0 2 2 2 0 SpoU rRNA Methylase family Aminotran_1_2 PF00155.21 EMC77761.1 - 2.1e-56 191.7 0.0 2.4e-56 191.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EMC77761.1 - 0.0062 15.1 0.0 0.02 13.4 0.0 1.8 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EMC77761.1 - 0.017 14.5 0.0 0.03 13.6 0.0 1.4 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Pannexin_like PF12534.8 EMC77762.1 - 2.1e-144 480.9 5.6 2.7e-144 480.6 5.6 1.1 1 0 0 1 1 1 1 Pannexin-like TM region of LRRC8 LRR_8 PF13855.6 EMC77762.1 - 9.7e-30 102.1 39.6 8.3e-10 38.3 2.5 6.9 5 2 0 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EMC77762.1 - 2e-27 94.8 50.7 1.3e-06 28.6 1.1 9.5 5 3 2 9 9 9 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC77762.1 - 6.2e-11 42.4 0.6 9.7e-05 22.3 0.3 4.0 1 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC77762.1 - 1.7e-07 30.9 20.0 8.7e-05 22.1 1.6 3.8 1 1 2 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.6 EMC77762.1 - 0.04 14.0 0.3 0.04 14.0 0.3 8.5 9 0 0 9 9 9 0 Leucine Rich repeat PhyH PF05721.13 EMC77763.1 - 1.5e-63 214.9 0.0 1.8e-63 214.6 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Nup188 PF10487.9 EMC77765.1 - 4.4e-228 759.6 0.7 4.4e-228 759.6 0.7 1.6 2 0 0 2 2 2 1 Nucleoporin subcomplex protein binding to Pom34 BAR PF03114.18 EMC77766.1 - 6.4e-67 225.7 1.6 1.2e-66 224.8 1.6 1.4 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.6 EMC77766.1 - 5.6e-11 42.1 0.1 1.1e-10 41.2 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC77766.1 - 1.6e-06 27.6 0.0 3.4e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC77766.1 - 1.7e-06 27.6 0.0 3.3e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 SH3 domain BAR_2 PF10455.9 EMC77766.1 - 8.6e-06 25.1 0.2 1.5e-05 24.3 0.0 1.4 2 0 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3 PF16746.5 EMC77766.1 - 0.00027 20.7 0.7 0.56 9.9 1.2 2.2 1 1 1 2 2 2 2 BAR domain of APPL family Miga PF10265.9 EMC77767.1 - 2.4e-229 762.8 0.4 2.7e-229 762.7 0.4 1.0 1 0 0 1 1 1 1 Mitoguardin Ribosomal_S7 PF00177.21 EMC77767.1 - 0.12 12.1 0.0 0.28 10.8 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein S7p/S5e DUF3824 PF12868.7 EMC77767.1 - 0.15 12.7 0.2 0.36 11.5 0.2 1.5 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) PAP2 PF01569.21 EMC77768.1 - 5.5e-18 65.0 5.8 1e-17 64.2 5.8 1.4 1 0 0 1 1 1 1 PAP2 superfamily UbiA PF01040.18 EMC77768.1 - 0.0024 17.2 7.6 0.0024 17.2 7.6 2.0 2 0 0 2 2 2 1 UbiA prenyltransferase family WTF PF03303.13 EMC77768.1 - 0.053 13.2 0.7 0.067 12.9 0.7 1.2 1 0 0 1 1 1 0 WTF protein Phage_holin_3_1 PF05106.12 EMC77768.1 - 0.065 13.7 0.4 0.12 12.8 0.4 1.4 1 0 0 1 1 1 0 Phage holin family (Lysis protein S) DUF212 PF02681.14 EMC77768.1 - 0.066 13.3 0.7 1.4 9.0 0.1 2.3 1 1 1 2 2 2 0 Divergent PAP2 family PSI_PsaJ PF01701.18 EMC77768.1 - 0.19 12.3 5.7 3 8.4 0.1 3.3 3 0 0 3 3 3 0 Photosystem I reaction centre subunit IX / PsaJ Carn_acyltransf PF00755.20 EMC77769.1 - 3.1e-206 686.5 0.0 3.5e-206 686.4 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase PTPA PF03095.15 EMC77770.1 - 4.4e-122 407.3 0.0 5.1e-122 407.0 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Methyltransf_PK PF05891.12 EMC77771.1 - 1.1e-90 303.0 0.0 1.2e-90 302.8 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 EMC77771.1 - 1.4e-12 48.2 0.0 4.1e-12 46.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC77771.1 - 8.5e-11 42.4 0.0 1.5e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC77771.1 - 3.9e-09 37.2 0.0 6.9e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 EMC77771.1 - 3.6e-06 26.4 0.0 8.2e-06 25.3 0.0 1.4 1 1 0 1 1 1 1 O-methyltransferase domain Methyltransf_31 PF13847.6 EMC77771.1 - 9.3e-05 22.3 0.0 0.00013 21.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMC77771.1 - 0.00018 21.0 0.0 0.00024 20.5 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EMC77771.1 - 0.022 14.3 0.0 0.037 13.6 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase small domain Dioxygenase_N PF04444.14 EMC77771.1 - 0.092 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Catechol dioxygenase N terminus DREV PF05219.12 EMC77771.1 - 0.15 11.1 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_29 PF03141.16 EMC77771.1 - 0.17 10.4 0.0 0.24 9.9 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Homeodomain PF00046.29 EMC77772.1 - 2.9e-23 81.5 6.9 5.7e-23 80.5 6.9 1.5 1 0 0 1 1 1 1 Homeodomain OAR PF03826.17 EMC77772.1 - 3.7e-08 32.9 0.1 9.1e-08 31.7 0.1 1.7 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.11 EMC77772.1 - 0.00029 20.7 0.1 0.00029 20.7 0.1 1.8 2 0 0 2 2 2 1 Homeobox KN domain MAPEG PF01124.18 EMC77773.1 - 2.1e-20 72.9 0.2 3.1e-20 72.4 0.2 1.2 1 0 0 1 1 1 1 MAPEG family Torsin PF06309.11 EMC77774.1 - 1.4e-43 148.0 0.0 2.3e-43 147.3 0.0 1.4 1 0 0 1 1 1 1 Torsin AAA PF00004.29 EMC77774.1 - 0.00053 20.4 0.0 0.00091 19.7 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 EMC77774.1 - 0.0065 16.2 0.0 0.0098 15.7 0.0 1.2 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 EMC77774.1 - 0.0092 16.3 0.0 0.4 11.0 0.0 2.2 1 1 0 1 1 1 1 AAA domain Torsin PF06309.11 EMC77775.1 - 2.1e-47 160.4 0.4 3.4e-47 159.7 0.4 1.4 1 0 0 1 1 1 1 Torsin AAA PF00004.29 EMC77775.1 - 0.0072 16.7 0.0 0.013 15.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EMC77775.1 - 0.022 14.8 0.0 0.038 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EMC77775.1 - 0.052 13.8 0.1 6.1 7.1 0.0 2.3 1 1 1 2 2 2 0 AAA domain Hep_59 PF07052.11 EMC77776.1 - 2.5e-15 57.1 7.2 2.5e-15 57.1 7.2 3.0 3 1 0 3 3 3 1 Hepatocellular carcinoma-associated antigen 59 FCH PF00611.23 EMC77777.1 - 6.6e-19 68.0 2.5 6.6e-19 68.0 2.5 3.0 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.6 EMC77777.1 - 8.6e-10 38.3 0.2 1.8e-09 37.3 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC77777.1 - 1.8e-09 37.0 0.1 4e-09 35.9 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC77777.1 - 5e-06 26.1 0.1 1.1e-05 25.0 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 EMC77777.1 - 0.00017 21.8 0.2 0.00033 20.9 0.2 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain HR1 PF02185.16 EMC77777.1 - 0.00051 20.1 0.2 0.00051 20.1 0.2 3.2 4 0 0 4 4 4 1 Hr1 repeat Lzipper-MIP1 PF14389.6 EMC77777.1 - 0.00056 20.1 0.7 0.0021 18.3 0.7 1.9 1 0 0 1 1 1 1 Leucine-zipper of ternary complex factor MIP1 Laminin_II PF06009.12 EMC77777.1 - 0.0025 17.9 4.2 0.81 9.7 0.2 3.0 2 0 0 2 2 2 2 Laminin Domain II SH3_16 PF18348.1 EMC77777.1 - 0.14 11.9 0.1 0.36 10.7 0.1 1.7 1 0 0 1 1 1 0 Bacterial dipeptidyl-peptidase Sh3 domain Spectrin PF00435.21 EMC77777.1 - 1.3 9.6 22.9 0.35 11.4 3.1 4.0 2 1 1 3 3 3 0 Spectrin repeat zf-C4H2 PF10146.9 EMC77777.1 - 2.6 8.3 24.3 0.096 13.0 11.9 3.5 1 1 2 3 3 3 0 Zinc finger-containing protein DUF1664 PF07889.12 EMC77777.1 - 7.4 6.6 14.0 2.9 7.9 1.4 3.6 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) EF-hand_7 PF13499.6 EMC77778.1 - 1.9e-25 89.1 4.1 2.5e-18 66.3 0.3 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 EMC77778.1 - 5.8e-24 81.8 5.2 2.7e-07 29.7 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 EMC77778.1 - 6.8e-23 78.6 3.5 8.5e-06 25.3 0.1 4.7 5 0 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 EMC77778.1 - 1.6e-17 62.1 4.9 4.8e-05 22.7 0.4 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EMC77778.1 - 3.3e-13 49.2 4.4 0.0001 22.1 0.3 3.6 1 1 2 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EMC77778.1 - 3.8e-05 24.0 0.8 0.041 14.2 0.2 3.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EMC77778.1 - 0.00041 20.3 2.4 0.72 9.8 0.1 3.1 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EMC77778.1 - 0.00054 20.2 0.1 0.036 14.4 0.0 3.0 2 1 1 3 3 3 1 EF-hand domain EF-hand_3 PF09069.11 EMC77778.1 - 0.0055 17.1 0.1 0.037 14.5 0.0 1.9 2 0 0 2 2 2 1 EF-hand Caleosin PF05042.13 EMC77778.1 - 0.0076 16.2 1.6 8.1 6.3 0.0 3.1 1 1 2 3 3 3 1 Caleosin related protein EF-hand_14 PF17959.1 EMC77778.1 - 0.081 13.3 0.1 1.7 9.1 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain DUF1707 PF08044.11 EMC77778.1 - 0.095 12.8 0.1 7.9 6.6 0.0 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF1707) DUF1708 PF08101.11 EMC77778.1 - 0.14 11.3 0.0 0.2 10.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1708) S10_plectin PF03501.15 EMC77778.1 - 0.17 12.0 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Plectin/S10 domain EF-hand_2 PF09068.11 EMC77778.1 - 0.19 11.9 0.0 2.7 8.2 0.0 2.2 2 0 0 2 2 2 0 EF hand Ig_3 PF13927.6 EMC77779.1 - 4.8e-42 142.4 0.0 3e-12 47.0 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.16 EMC77779.1 - 5.3e-41 138.6 0.0 2.6e-12 46.6 0.0 4.6 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC77779.1 - 1.2e-32 112.1 0.0 2.2e-07 31.1 0.0 4.4 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 EMC77779.1 - 2e-30 104.8 0.0 6.5e-07 29.4 0.0 4.8 4 1 0 4 4 4 4 Immunoglobulin domain V-set PF07686.17 EMC77779.1 - 2.5e-15 56.6 0.4 0.22 11.7 0.0 7.0 6 2 1 7 7 7 5 Immunoglobulin V-set domain Ig_6 PF18452.1 EMC77779.1 - 0.00024 20.6 0.0 0.57 9.8 0.0 3.9 4 0 0 4 4 4 1 Immunoglobulin domain Ig_5 PF16681.5 EMC77779.1 - 0.00085 19.7 0.0 3.8 8.0 0.0 3.8 4 0 0 4 4 4 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 EMC77779.1 - 0.0033 17.4 0.0 26 5.0 0.0 4.1 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain VWA_2 PF13519.6 EMC77779.1 - 0.0079 16.8 0.0 0.022 15.4 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain Arginosuc_synth PF00764.19 EMC77780.1 - 4.1e-139 464.2 0.0 4.7e-139 464.0 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 EMC77780.1 - 4.6e-05 23.0 0.0 7e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 EMC77780.1 - 0.0034 16.2 0.0 0.006 15.4 0.0 1.4 1 1 0 1 1 1 1 tRNA methyl transferase Ish1 PF10281.9 EMC77780.1 - 0.2 12.0 0.0 3.6 8.0 0.0 2.6 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein KH_1 PF00013.29 EMC77781.1 - 9e-69 227.2 17.1 2.3e-18 65.7 0.3 4.2 4 0 0 4 4 4 4 KH domain KH_2 PF07650.17 EMC77781.1 - 4.8e-22 77.6 8.9 1.3e-05 24.9 0.0 4.4 4 0 0 4 4 4 4 KH domain KH_4 PF13083.6 EMC77781.1 - 1.8e-12 47.0 8.4 0.025 14.4 0.1 4.3 4 0 0 4 4 4 4 KH domain DUF1897 PF09005.10 EMC77781.1 - 0.00061 19.2 8.9 0.0014 18.0 8.9 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1897) KH_5 PF13184.6 EMC77781.1 - 0.0042 17.2 10.3 10 6.3 0.1 4.4 4 0 0 4 4 4 3 NusA-like KH domain CBM_3 PF00942.18 EMC77782.1 - 0.0038 17.6 0.2 0.0052 17.2 0.2 1.2 1 0 0 1 1 1 1 Cellulose binding domain ECR1_N PF14382.6 EMC77783.1 - 2.9e-16 59.0 0.6 5.4e-16 58.1 0.6 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 EMC77783.1 - 8e-14 51.7 0.0 1.9e-13 50.5 0.0 1.7 1 0 0 1 1 1 1 KH domain SH3_1 PF00018.28 EMC77784.1 - 4.5e-08 32.6 0.2 1.4e-07 31.0 0.2 1.8 1 1 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC77784.1 - 0.00021 21.1 0.5 0.0019 18.0 0.6 2.3 2 1 0 2 2 2 1 Variant SH3 domain SH3_3 PF08239.11 EMC77784.1 - 0.00077 19.7 0.2 0.0012 19.1 0.2 1.3 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_2 PF07653.17 EMC77784.1 - 0.0085 15.8 0.1 0.014 15.1 0.1 1.5 1 1 0 1 1 1 1 Variant SH3 domain SH3_6 PF12913.7 EMC77784.1 - 0.016 14.8 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 SH3 domain (SH3b1 type) TraP PF07296.11 EMC77785.1 - 0.098 11.8 0.0 0.2 10.8 0.0 1.4 1 0 0 1 1 1 0 TraP protein Claudin_2 PF13903.6 EMC77786.1 - 1.1e-10 41.6 5.7 1.5e-10 41.1 5.7 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 EMC77786.1 - 9.9e-05 22.3 5.0 0.00014 21.8 5.0 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family DAGK_cat PF00781.24 EMC77787.1 - 7.9e-25 86.9 0.1 1.2e-24 86.3 0.1 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Tim54 PF11711.8 EMC77787.1 - 0.00013 20.9 0.0 0.00072 18.4 0.0 2.0 2 0 0 2 2 2 1 Inner membrane protein import complex subunit Tim54 NAD_kinase PF01513.21 EMC77787.1 - 0.0012 18.2 0.0 0.0016 17.7 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase GATase PF00117.28 EMC77787.1 - 0.026 14.3 0.0 0.065 13.0 0.0 1.6 2 0 0 2 2 2 0 Glutamine amidotransferase class-I DUF5516 PF17637.2 EMC77787.1 - 0.12 12.2 0.6 0.23 11.3 0.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5516) DUF2347 PF09804.9 EMC77788.1 - 4e-73 246.5 0.0 5.2e-73 246.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) SPA PF08616.10 EMC77788.1 - 1.3e-13 50.9 0.0 2.3e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 EMC77788.1 - 2.4e-09 36.4 1.9 0.00031 19.6 0.1 3.2 2 1 0 2 2 2 2 Transport protein Avl9 Baculo_LEF-11 PF06385.12 EMC77788.1 - 0.067 13.7 0.8 0.13 12.8 0.8 1.4 1 0 0 1 1 1 0 Baculovirus LEF-11 protein Pkinase PF00069.25 EMC77789.1 - 4e-53 180.5 0.0 5.3e-53 180.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC77789.1 - 1.4e-22 80.3 0.0 2.2e-22 79.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase SSB PF00436.25 EMC77790.1 - 7.8e-32 109.4 0.3 9.4e-32 109.2 0.3 1.1 1 0 0 1 1 1 1 Single-strand binding protein family Ribosomal_L37 PF08561.10 EMC77791.1 - 1.1e-09 38.8 0.4 1.5e-09 38.4 0.4 1.3 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L37 MALT1_Ig PF18703.1 EMC77792.1 - 2.1e-48 163.8 0.0 5.9e-48 162.4 0.0 1.8 2 0 0 2 2 2 1 MALT1 Ig-like domain Ig_3 PF13927.6 EMC77792.1 - 4.9e-20 71.9 0.7 1.8e-10 41.2 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain Peptidase_C14 PF00656.22 EMC77792.1 - 2.3e-18 67.1 0.0 6.3e-18 65.6 0.0 1.7 1 1 0 1 1 1 1 Caspase domain Ig_2 PF13895.6 EMC77792.1 - 3.3e-15 56.2 4.3 8.1e-09 35.7 0.0 2.7 3 0 0 3 3 2 2 Immunoglobulin domain I-set PF07679.16 EMC77792.1 - 2.2e-14 53.3 0.1 5.3e-08 32.8 0.0 3.2 3 1 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 EMC77792.1 - 1.4e-09 38.0 0.3 0.001 19.2 0.0 3.0 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 EMC77792.1 - 2.1e-05 24.7 1.0 1.6 9.0 0.1 3.4 2 1 1 3 3 3 3 Immunoglobulin V-set domain Ig_5 PF16681.5 EMC77792.1 - 0.0013 19.0 0.0 3.1 8.2 0.0 2.5 2 0 0 2 2 2 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Death PF00531.22 EMC77792.1 - 0.0061 16.7 0.0 0.016 15.3 0.0 1.8 1 0 0 1 1 1 1 Death domain Ig_4 PF16680.5 EMC77792.1 - 0.0077 16.5 0.0 0.27 11.5 0.0 2.5 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 EMC77792.1 - 0.025 14.6 1.3 0.46 10.6 0.1 2.6 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Pkinase_Tyr PF07714.17 EMC77793.1 - 2.3e-88 295.8 0.0 3e-88 295.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC77793.1 - 3.1e-47 161.1 0.0 4.8e-47 160.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 EMC77793.1 - 5.7e-20 71.2 0.0 1.3e-19 70.1 0.0 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 EMC77793.1 - 7.7e-10 38.2 0.0 1.5e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC77793.1 - 1.8e-06 27.7 0.0 5.4e-06 26.2 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC77793.1 - 0.00028 20.5 0.0 0.00058 19.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain APH PF01636.23 EMC77793.1 - 0.0033 17.4 0.0 0.01 15.8 0.0 1.7 2 1 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EMC77793.1 - 0.0057 15.6 0.1 0.0091 15.0 0.1 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EMC77793.1 - 0.0073 15.7 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like SH3_3 PF08239.11 EMC77793.1 - 0.013 15.7 0.0 0.03 14.6 0.0 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain RIO1 PF01163.22 EMC77793.1 - 0.032 13.8 0.1 0.061 12.9 0.1 1.4 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 EMC77793.1 - 0.045 12.5 0.0 0.069 11.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase RRM_1 PF00076.22 EMC77794.1 - 1.9e-62 207.0 0.1 1.3e-19 69.7 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMC77794.1 - 2.5e-11 43.2 0.0 0.0014 18.2 0.0 3.1 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 EMC77794.1 - 1.2e-05 25.4 0.0 0.04 14.1 0.0 2.9 3 0 0 3 3 3 2 BRCA1-associated protein 2 RRM_3 PF08777.11 EMC77794.1 - 0.00042 20.3 0.0 0.17 11.9 0.0 2.6 2 0 0 2 2 2 2 RNA binding motif RRM_occluded PF16842.5 EMC77794.1 - 0.0022 17.8 0.0 1.2 9.0 0.0 2.9 3 1 0 3 3 3 2 Occluded RNA-recognition motif RRM_7 PF16367.5 EMC77794.1 - 0.0042 17.2 0.0 1.5 9.0 0.0 3.3 3 0 0 3 3 3 1 RNA recognition motif E2 PF08199.11 EMC77794.1 - 0.1 12.5 0.0 0.35 10.8 0.0 1.9 1 0 0 1 1 1 0 Bacteriophage E2-like protein SET_assoc PF11767.8 EMC77794.1 - 0.12 12.1 0.0 5.9 6.6 0.0 2.6 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated hSH3 PF14603.6 EMC77795.1 - 4e-27 94.5 0.0 4.6e-27 94.3 0.0 1.1 1 0 0 1 1 1 1 Helically-extended SH3 domain SH3_2 PF07653.17 EMC77795.1 - 0.00024 20.7 0.0 0.00025 20.7 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EMC77795.1 - 0.037 13.9 0.0 0.053 13.4 0.0 1.2 1 0 0 1 1 1 0 Variant SH3 domain SH3_1 PF00018.28 EMC77795.1 - 0.054 13.1 0.0 0.077 12.6 0.0 1.3 1 0 0 1 1 1 0 SH3 domain CBFD_NFYB_HMF PF00808.23 EMC77797.1 - 9.5e-07 29.0 0.0 1.2e-06 28.7 0.0 1.1 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EMC77797.1 - 1.2e-05 25.6 0.1 1.4e-05 25.5 0.1 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EMC77797.1 - 0.0061 16.7 0.1 0.0065 16.6 0.1 1.1 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 EMC77797.1 - 0.009 16.2 0.0 0.011 15.9 0.0 1.1 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) TFIID-31kDa PF02291.15 EMC77797.1 - 0.015 15.3 0.1 0.016 15.3 0.1 1.0 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit SlpA PF03217.14 EMC77797.1 - 0.026 15.1 0.1 0.027 15.1 0.1 1.1 1 0 0 1 1 1 0 Surface later protein A domain Glyco_hydro_56 PF01630.18 EMC77798.1 - 4.6e-142 473.0 0.2 5.5e-142 472.7 0.2 1.1 1 0 0 1 1 1 1 Hyaluronidase Arf PF00025.21 EMC77799.1 - 1.8e-38 131.7 0.0 2.2e-38 131.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EMC77799.1 - 8.1e-13 48.3 0.0 9e-13 48.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC77799.1 - 4e-10 40.0 0.0 5.9e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EMC77799.1 - 1.6e-05 24.3 0.0 1.8e-05 24.1 0.0 1.3 1 1 0 1 1 1 1 G-protein alpha subunit Gtr1_RagA PF04670.12 EMC77799.1 - 3.1e-05 23.4 0.0 3.6e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMC77799.1 - 0.023 14.8 0.0 0.23 11.6 0.0 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase 7tm_4 PF13853.6 EMC77800.1 - 1.2e-48 166.3 10.6 1.4e-48 166.0 10.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC77800.1 - 2.2e-31 109.1 15.4 3.1e-31 108.7 15.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC77800.1 - 0.00011 21.7 11.3 0.00018 21.0 11.3 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Se-cys_synth_N PF12390.8 EMC77801.1 - 3.3 8.0 29.0 5.3 7.3 0.4 7.0 7 2 0 7 7 7 0 Selenocysteine synthase N terminal OLF PF02191.16 EMC77802.1 - 8.2e-69 231.9 0.1 1e-68 231.6 0.1 1.1 1 0 0 1 1 1 1 Olfactomedin-like domain Gal_Lectin PF02140.18 EMC77802.1 - 5.6e-23 81.2 0.8 8.9e-23 80.5 0.8 1.3 1 0 0 1 1 1 1 Galactose binding lectin domain DUF5074 PF16819.5 EMC77802.1 - 0.15 12.2 0.4 2.1 8.4 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF5074) Sox_N PF12444.8 EMC77803.1 - 0.00026 22.1 0.4 55 5.0 0.0 5.8 4 2 2 6 6 6 2 Sox developmental protein N terminal Lectin_C PF00059.21 EMC77805.1 - 4.3e-08 33.8 0.4 4.3e-08 33.8 0.4 1.6 1 1 1 2 2 2 1 Lectin C-type domain UL45 PF05473.12 EMC77805.1 - 0.00013 21.6 0.2 0.00013 21.6 0.2 1.6 2 0 0 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like Choline_transpo PF04515.12 EMC77805.1 - 0.049 12.8 0.6 0.052 12.8 0.6 1.1 1 0 0 1 1 1 0 Plasma-membrane choline transporter Ly49 PF08391.10 EMC77805.1 - 0.14 12.5 0.5 0.14 12.5 0.5 2.5 2 1 1 3 3 3 0 Ly49-like protein, N-terminal region TMEM52 PF14979.6 EMC77806.1 - 4.1e-56 189.0 0.2 4.9e-56 188.8 0.2 1.0 1 0 0 1 1 1 1 Transmembrane 52 Mucin PF01456.17 EMC77806.1 - 0.042 13.8 0.7 0.057 13.4 0.7 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Prominin PF05478.11 EMC77806.1 - 2.9 5.7 4.2 4.4 5.1 4.2 1.2 1 0 0 1 1 1 0 Prominin Atg8 PF02991.16 EMC77807.1 - 2.6e-49 165.7 0.2 2.9e-49 165.5 0.2 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EMC77807.1 - 3.8e-08 33.6 0.0 4.7e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 VitD-bind_III PF09164.10 EMC77807.1 - 0.18 11.8 0.5 0.3 11.1 0.5 1.3 1 0 0 1 1 1 0 Vitamin D binding protein, domain III Pkinase_Tyr PF07714.17 EMC77808.1 - 3.2e-65 220.0 0.0 4.3e-65 219.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC77808.1 - 1.5e-31 109.8 0.0 2.2e-31 109.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 EMC77808.1 - 8.2e-05 22.0 0.0 0.00016 21.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like TMEM154 PF15102.6 EMC77808.1 - 0.03 14.2 0.0 0.048 13.6 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family Kdo PF06293.14 EMC77808.1 - 0.089 12.1 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EphA2_TM PF14575.6 EMC77808.1 - 0.11 13.4 0.0 0.23 12.3 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TLV_coat PF00429.19 EMC77809.1 - 1.3e-46 159.5 0.7 1.4e-46 159.3 0.7 1.0 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) S6OS1 PF15676.5 EMC77809.1 - 0.043 12.3 0.3 0.051 12.0 0.3 1.0 1 0 0 1 1 1 0 Six6 opposite strand transcript 1 family GP41 PF00517.17 EMC77809.1 - 0.045 13.7 0.0 0.055 13.4 0.0 1.1 1 0 0 1 1 1 0 Retroviral envelope protein PAP2_3 PF14378.6 EMC77809.1 - 0.049 13.3 0.2 0.062 13.0 0.2 1.1 1 0 0 1 1 1 0 PAP2 superfamily DUF2207 PF09972.9 EMC77809.1 - 0.049 12.4 0.0 0.049 12.4 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3899 PF13038.6 EMC77809.1 - 0.076 13.5 0.0 0.1 13.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3899) DUF3687 PF12459.8 EMC77809.1 - 0.13 11.8 0.1 0.21 11.1 0.1 1.3 1 0 0 1 1 1 0 D-Ala-teichoic acid biosynthesis protein TMEMspv1-c74-12 PF11044.8 EMC77809.1 - 0.21 11.6 0.2 0.21 11.6 0.2 1.6 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Synaptonemal_3 PF15191.6 EMC77810.1 - 4.4e-32 109.7 5.5 5e-32 109.5 5.5 1.0 1 0 0 1 1 1 1 Synaptonemal complex central element protein 3 DUF4456 PF14644.6 EMC77810.1 - 0.015 15.0 0.5 0.017 14.8 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4456) Med9 PF07544.13 EMC77810.1 - 0.029 14.5 0.9 2.4 8.3 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DASH_Dad3 PF08656.10 EMC77810.1 - 0.08 13.0 0.8 0.5 10.5 0.1 2.0 2 0 0 2 2 2 0 DASH complex subunit Dad3 TraF_2 PF13729.6 EMC77810.1 - 0.16 11.3 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 F plasmid transfer operon, TraF, protein FlaC_arch PF05377.11 EMC77810.1 - 0.53 10.7 3.8 0.41 11.1 0.9 2.0 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) CSD PF00313.22 EMC77811.1 - 1.4e-26 92.1 0.5 2.1e-26 91.6 0.5 1.3 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 EMC77811.1 - 0.0065 16.1 0.0 0.019 14.7 0.0 1.7 2 0 0 2 2 2 1 Ribonuclease B OB domain DPPIV_N PF00930.21 EMC77812.1 - 5.9e-111 370.6 0.1 8.3e-111 370.2 0.1 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EMC77812.1 - 3.7e-36 124.6 0.1 7.2e-36 123.7 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family PD40 PF07676.12 EMC77812.1 - 1.1e-06 28.4 0.1 0.031 14.2 0.0 3.1 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat DLH PF01738.18 EMC77812.1 - 3.2e-05 23.6 0.2 0.00014 21.5 0.2 1.9 1 1 0 1 1 1 1 Dienelactone hydrolase family PTCB-BRCT PF12738.7 EMC77813.1 - 4.8e-55 183.4 2.7 7.4e-21 73.9 0.0 4.7 4 0 0 4 4 4 4 twin BRCT domain BRCT PF00533.26 EMC77813.1 - 3.9e-50 168.2 3.1 2.9e-13 50.0 0.0 5.9 6 0 0 6 6 6 5 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EMC77813.1 - 3.5e-31 107.5 0.8 2.1e-06 28.1 0.1 6.0 6 0 0 6 6 6 5 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 EMC77813.1 - 4.4e-25 87.5 4.9 2.3e-20 72.3 0.1 4.1 4 0 0 4 4 4 2 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.5 EMC77813.1 - 5.9e-13 48.9 4.5 0.00032 20.9 0.0 5.7 6 0 0 6 6 6 3 DNA ligase 3 BRCT domain 7tm_1 PF00001.21 EMC77814.1 - 6.2e-72 242.1 10.7 1e-71 241.4 10.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC77814.1 - 8.9e-07 28.8 5.5 2e-06 27.6 5.5 1.6 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC77814.1 - 0.00037 20.3 1.2 0.00087 19.1 1.2 1.5 1 0 0 1 1 1 1 Olfactory receptor OppC_N PF12911.7 EMC77814.1 - 0.042 13.8 0.3 0.042 13.8 0.3 3.0 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C Amnionless PF14828.6 EMC77814.1 - 0.11 11.3 0.3 2.2 7.0 0.3 2.2 2 0 0 2 2 2 0 Amnionless zf-LITAF-like PF10601.9 EMC77814.1 - 0.67 10.3 6.5 2.9 8.2 0.2 4.0 4 0 0 4 4 4 0 LITAF-like zinc ribbon domain INSIG PF07281.12 EMC77815.1 - 1.2e-28 100.2 9.3 1.1e-21 77.5 5.6 2.9 2 1 0 2 2 2 2 Insulin-induced protein (INSIG) DUF202 PF02656.15 EMC77815.1 - 0.3 11.6 4.5 0.81 10.2 1.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF202) RRM_1 PF00076.22 EMC77817.1 - 0.0055 16.5 0.0 0.01 15.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMC77817.1 - 0.091 12.6 0.0 0.3 11.0 0.1 1.8 2 0 0 2 2 2 0 Occluded RNA-recognition motif RRM_3 PF08777.11 EMC77817.1 - 1 9.5 0.0 1 9.5 0.0 4.0 4 1 0 4 4 4 0 RNA binding motif zf-RING_2 PF13639.6 EMC77818.1 - 7.6e-13 48.6 30.0 1.6e-06 28.4 12.5 3.3 2 1 0 2 2 2 2 Ring finger domain zf-RING_5 PF14634.6 EMC77818.1 - 1.9e-09 37.3 31.4 6.9e-05 22.7 13.1 3.1 2 1 1 3 3 3 2 zinc-RING finger domain zf-RING_UBOX PF13445.6 EMC77818.1 - 4.4e-09 36.2 24.3 1.9e-06 27.8 4.6 3.8 2 2 1 3 3 3 2 RING-type zinc-finger zf-RING_11 PF17123.5 EMC77818.1 - 2.7e-08 33.4 20.3 1.3e-05 24.9 3.8 3.8 3 0 0 3 3 3 2 RING-like zinc finger zf-ANAPC11 PF12861.7 EMC77818.1 - 5.7e-08 32.7 16.8 0.0012 18.8 2.0 3.4 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EMC77818.1 - 9.2e-08 32.3 27.6 0.0024 18.1 7.2 3.5 2 2 0 2 2 2 2 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EMC77818.1 - 5.7e-07 29.3 27.4 0.00064 19.5 3.1 3.3 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) IQ PF00612.27 EMC77818.1 - 1.8e-06 27.2 3.1 9.2e-06 25.0 3.1 2.4 1 0 0 1 1 1 1 IQ calmodulin-binding motif zf-C3HC4 PF00097.25 EMC77818.1 - 2.6e-06 27.2 31.1 0.00042 20.1 13.1 3.3 2 1 1 3 3 3 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC77818.1 - 5.1e-06 26.3 26.5 0.0014 18.4 3.3 3.5 3 0 0 3 3 3 2 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EMC77818.1 - 0.00034 20.4 31.6 0.042 13.7 13.5 3.4 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) E3_UbLigase_R4 PF13764.6 EMC77818.1 - 0.073 11.2 0.1 0.1 10.7 0.1 1.2 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase UBR4 Pellino PF04710.14 EMC77818.1 - 0.38 9.4 7.3 0.47 9.1 1.9 2.2 2 0 0 2 2 2 0 Pellino Zn_ribbon_17 PF17120.5 EMC77818.1 - 0.66 9.6 21.4 1.1 9.0 8.4 3.0 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type Rtf2 PF04641.12 EMC77818.1 - 1.5 8.2 12.0 0.76 9.1 4.2 2.4 2 0 0 2 2 2 0 Rtf2 RING-finger zf-RING_4 PF14570.6 EMC77818.1 - 2.1 8.2 22.3 0.46 10.3 0.6 3.3 3 1 1 4 4 4 0 RING/Ubox like zinc-binding domain LMBR1 PF04791.16 EMC77819.1 - 8e-92 308.8 26.2 9.7e-56 189.7 13.5 2.0 1 1 1 2 2 2 2 LMBR1-like membrane protein DUF2951 PF11166.8 EMC77819.1 - 0.022 15.0 0.4 0.058 13.6 0.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) Orf78 PF06024.12 EMC77819.1 - 0.027 14.8 0.3 0.027 14.8 0.3 3.7 4 0 0 4 4 4 0 Orf78 (ac78) Sigma_reg_N PF13800.6 EMC77819.1 - 0.1 12.9 0.1 0.1 12.9 0.1 4.7 5 1 0 5 5 5 0 Sigma factor regulator N-terminal CrgA PF06781.12 EMC77819.1 - 7.2 6.7 9.8 2.8 8.1 0.6 3.5 4 0 0 4 4 4 0 Cell division protein CrgA Homeodomain PF00046.29 EMC77820.1 - 2.5e-22 78.5 6.8 3.8e-22 77.9 6.8 1.3 1 0 0 1 1 1 1 Homeodomain QLQ PF08880.11 EMC77820.1 - 0.00072 19.3 0.5 0.00072 19.3 0.5 1.7 2 0 0 2 2 2 1 QLQ DFRP_C PF16543.5 EMC77820.1 - 0.029 14.8 4.9 0.051 14.1 4.9 1.5 1 0 0 1 1 1 0 DRG Family Regulatory Proteins, Tma46 Pox_Ag35 PF03286.14 EMC77820.1 - 0.43 10.3 6.0 0.62 9.8 6.0 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein HECT PF00632.25 EMC77821.1 - 7.6e-96 321.2 0.0 1.3e-95 320.5 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 EMC77821.1 - 0.00037 20.0 0.1 0.00098 18.7 0.1 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif Lon_C PF05362.13 EMC77822.1 - 6.7e-25 87.8 0.0 2.2e-24 86.2 0.0 1.9 2 0 0 2 2 2 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 EMC77822.1 - 1.2e-24 87.2 0.0 3.6e-24 85.7 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) LON_substr_bdg PF02190.16 EMC77822.1 - 4.3e-24 85.5 8.2 4.3e-24 85.5 8.2 2.2 2 1 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA_5 PF07728.14 EMC77822.1 - 3.7e-09 36.7 0.0 1.4e-08 34.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EMC77822.1 - 2.6e-08 34.2 0.0 1.1e-07 32.1 0.0 2.1 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EMC77822.1 - 2.9e-07 31.0 2.0 1.1e-05 25.9 0.0 3.5 3 1 1 4 4 4 1 AAA ATPase domain RuvB_N PF05496.12 EMC77822.1 - 5.4e-07 29.5 0.0 1.2e-05 25.2 0.0 2.6 3 0 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_PrkA PF08298.11 EMC77822.1 - 3.1e-06 26.3 0.0 6.3e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 PrkA AAA domain AAA_22 PF13401.6 EMC77822.1 - 9.4e-05 22.7 3.3 0.0011 19.3 0.0 3.7 4 1 0 4 4 3 1 AAA domain AAA_14 PF13173.6 EMC77822.1 - 0.00059 19.9 0.5 0.0031 17.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EMC77822.1 - 0.0015 18.9 0.0 0.0039 17.6 0.0 1.8 1 0 0 1 1 1 1 RNA helicase Acetate_kinase PF00871.17 EMC77822.1 - 0.0019 17.0 1.1 0.0029 16.4 1.1 1.3 1 0 0 1 1 1 1 Acetokinase family IstB_IS21 PF01695.17 EMC77822.1 - 0.0025 17.6 0.0 0.0072 16.1 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein LXG PF04740.12 EMC77822.1 - 0.012 15.3 0.9 0.17 11.6 0.3 2.9 3 0 0 3 3 3 0 LXG domain of WXG superfamily AAA_24 PF13479.6 EMC77822.1 - 0.02 14.6 0.5 0.071 12.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EMC77822.1 - 0.02 14.8 0.2 0.08 12.8 0.0 2.1 2 0 0 2 2 1 0 RsgA GTPase NB-ARC PF00931.22 EMC77822.1 - 0.021 14.0 0.9 0.078 12.2 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain AAA_3 PF07726.11 EMC77822.1 - 0.021 14.7 0.0 0.24 11.3 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EMC77822.1 - 0.023 14.6 0.0 0.1 12.5 0.0 2.2 1 1 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 EMC77822.1 - 0.026 15.1 0.0 0.026 15.1 0.0 2.8 3 0 0 3 3 2 0 AAA domain AAA_33 PF13671.6 EMC77822.1 - 0.035 14.3 0.1 0.2 11.8 0.0 2.5 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 EMC77822.1 - 0.036 14.1 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EMC77822.1 - 0.044 13.3 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 EMC77822.1 - 0.058 13.1 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 EMC77822.1 - 0.059 12.4 0.0 0.16 11.0 0.0 1.7 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ABC_tran PF00005.27 EMC77822.1 - 0.076 13.5 1.0 0.57 10.7 0.0 2.8 2 1 0 2 2 2 0 ABC transporter Viral_helicase1 PF01443.18 EMC77822.1 - 0.13 12.0 0.0 0.52 10.0 0.0 1.9 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_23 PF13476.6 EMC77822.1 - 0.14 12.6 0.0 0.14 12.6 0.0 3.3 2 2 0 2 2 1 0 AAA domain ATPase_2 PF01637.18 EMC77822.1 - 0.21 11.5 11.0 0.62 9.9 0.0 3.9 3 1 1 4 4 4 0 ATPase domain predominantly from Archaea CbiA PF01656.23 EMC77822.1 - 0.64 10.1 1.9 1.9 8.5 0.0 2.7 4 1 0 4 4 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_17 PF13207.6 EMC77822.1 - 0.76 10.2 0.0 0.76 10.2 0.0 3.7 4 1 0 4 4 3 0 AAA domain AAA_11 PF13086.6 EMC77822.1 - 1.1 9.0 0.0 1.1 9.0 0.0 3.1 3 1 0 3 3 1 0 AAA domain Ribosomal_L36e PF01158.18 EMC77823.1 - 1.4e-51 172.7 7.2 1.6e-51 172.5 7.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e Filament PF00038.21 EMC77824.1 - 2.3e-84 283.7 47.7 3.1e-84 283.2 47.7 1.2 1 0 0 1 1 1 1 Intermediate filament protein LTD PF00932.19 EMC77824.1 - 1.9e-18 66.9 0.4 4e-18 65.8 0.4 1.5 1 0 0 1 1 1 1 Lamin Tail Domain BRE1 PF08647.11 EMC77824.1 - 0.0011 19.0 9.1 0.0011 19.0 9.1 4.0 1 1 3 4 4 4 2 BRE1 E3 ubiquitin ligase Spc7 PF08317.11 EMC77824.1 - 0.054 12.4 44.9 0.2 10.5 13.4 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein FPP PF05911.11 EMC77824.1 - 0.13 10.4 42.1 0.12 10.6 23.3 3.0 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil DUF1844 PF08899.11 EMC77824.1 - 0.22 11.9 9.4 0.44 10.9 0.9 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF1844) DUF1664 PF07889.12 EMC77824.1 - 0.51 10.4 26.1 10 6.2 2.9 5.1 2 1 3 5 5 5 0 Protein of unknown function (DUF1664) PspB PF06667.12 EMC77824.1 - 1.3 9.1 5.3 0.33 11.0 0.7 2.6 2 0 0 2 2 2 0 Phage shock protein B zf-Tim10_DDP PF02953.15 EMC77825.1 - 7.9e-22 76.7 0.5 9.5e-22 76.4 0.5 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger TIL PF01826.17 EMC77825.1 - 0.062 13.6 1.6 0.086 13.1 1.6 1.2 1 0 0 1 1 1 0 Trypsin Inhibitor like cysteine rich domain PBP_GOBP PF01395.22 EMC77825.1 - 0.067 13.4 2.8 1.1 9.4 0.1 2.0 1 1 1 2 2 2 0 PBP/GOBP family Trypsin PF00089.26 EMC77826.1 - 9.9e-198 653.3 0.0 3e-70 236.5 0.0 3.3 3 0 0 3 3 3 3 Trypsin DUF1986 PF09342.11 EMC77826.1 - 6.5e-21 74.9 0.1 5.3e-07 30.0 0.0 3.4 3 0 0 3 3 3 3 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 EMC77826.1 - 1.3e-11 45.6 0.0 0.0014 19.5 0.0 3.7 3 1 0 3 3 3 2 Trypsin-like peptidase domain Mucin PF01456.17 EMC77826.1 - 6.8 6.7 26.8 0.16 12.0 14.5 2.3 2 0 0 2 2 2 0 Mucin-like glycoprotein Peptidase_A22B PF04258.13 EMC77827.1 - 1.8e-85 287.0 14.6 2.6e-85 286.4 14.6 1.2 1 0 0 1 1 1 1 Signal peptide peptidase PA PF02225.22 EMC77827.1 - 1.9e-08 34.2 0.0 4.6e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 PA domain DUF4079 PF13301.6 EMC77827.1 - 0.019 15.1 0.1 0.092 12.9 0.1 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) DUF4181 PF13789.6 EMC77827.1 - 8.3 6.7 8.2 2.1 8.6 0.1 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4181) LSM PF01423.22 EMC77828.1 - 8.1e-07 28.7 0.0 0.01 15.5 0.0 2.1 2 0 0 2 2 2 2 LSM domain Kelch_6 PF13964.6 EMC77829.1 - 1.5e-23 82.2 10.0 1.7e-05 24.9 0.2 6.5 4 2 2 6 6 6 5 Kelch motif BACK PF07707.15 EMC77829.1 - 7.8e-21 74.1 0.3 4.5e-20 71.7 0.0 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_1 PF01344.25 EMC77829.1 - 2.9e-19 68.4 16.7 0.0018 17.8 0.1 7.0 6 1 0 6 6 6 5 Kelch motif Kelch_5 PF13854.6 EMC77829.1 - 2.2e-07 30.7 4.6 0.19 11.8 0.1 5.6 6 0 0 6 6 6 3 Kelch motif Kelch_4 PF13418.6 EMC77829.1 - 4.7e-07 29.7 10.2 0.023 14.7 0.1 5.9 6 1 2 8 8 8 2 Galactose oxidase, central domain BTB PF00651.31 EMC77829.1 - 4.9e-07 30.0 0.0 7.8e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Kelch_2 PF07646.15 EMC77829.1 - 6.2e-07 29.1 8.7 0.31 11.1 0.1 5.7 5 1 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 EMC77829.1 - 8.8e-06 25.9 6.1 0.029 14.7 0.0 5.0 6 0 0 6 6 6 2 Galactose oxidase, central domain TRAM_LAG1_CLN8 PF03798.16 EMC77830.1 - 3.1e-41 141.3 26.3 4.4e-41 140.8 26.3 1.2 1 0 0 1 1 1 1 TLC domain Homeodomain PF00046.29 EMC77830.1 - 1.7e-05 24.5 0.2 5.6e-05 22.9 0.2 1.9 2 0 0 2 2 2 1 Homeodomain Lectin_C PF00059.21 EMC77831.1 - 6.4e-14 52.6 1.4 7.8e-14 52.3 1.4 1.1 1 0 0 1 1 1 1 Lectin C-type domain TSP_1 PF00090.19 EMC77834.1 - 2.9e-55 184.3 159.9 1.4e-06 28.4 6.8 15.6 14 1 0 14 14 14 12 Thrombospondin type 1 domain I-set PF07679.16 EMC77834.1 - 6.6e-31 106.2 0.0 1.5e-13 50.6 0.0 3.8 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC77834.1 - 3.1e-29 101.4 0.4 7.8e-11 42.4 0.0 4.3 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 EMC77834.1 - 6.3e-22 77.7 0.3 2.1e-09 37.6 0.0 4.7 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.25 EMC77834.1 - 2.8e-16 59.5 0.2 1.6e-08 34.6 0.0 3.8 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 EMC77834.1 - 3.3e-11 43.3 0.7 0.00086 19.5 0.0 5.0 3 2 1 4 4 4 2 Immunoglobulin V-set domain PLAC PF08686.11 EMC77834.1 - 2.9e-09 37.5 13.3 2.5e-08 34.5 13.3 2.9 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain ADAM_spacer1 PF05986.14 EMC77834.1 - 0.0066 16.5 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Izumo-Ig PF16706.5 EMC77834.1 - 0.033 14.3 0.0 9.5 6.4 0.0 2.9 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Filament PF00038.21 EMC77835.1 - 9.7e-54 183.0 38.1 9.7e-54 183.0 38.1 1.4 2 0 0 2 2 2 1 Intermediate filament protein LTD PF00932.19 EMC77835.1 - 1.7e-17 63.7 0.1 3.2e-17 62.9 0.1 1.4 1 0 0 1 1 1 1 Lamin Tail Domain DUF4559 PF15112.6 EMC77835.1 - 2 8.0 19.4 7.1 6.2 19.4 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4559) BAR PF03114.18 EMC77836.1 - 9.8e-78 261.1 8.2 1.2e-77 260.8 8.2 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 EMC77836.1 - 1e-14 53.9 0.1 3e-14 52.3 0.1 1.9 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC77836.1 - 1.2e-13 50.5 0.0 3.9e-13 48.8 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 EMC77836.1 - 2e-13 49.9 0.1 3.3e-13 49.3 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain BAR_2 PF10455.9 EMC77836.1 - 1e-07 31.4 4.8 4.8e-06 25.9 1.6 2.1 2 0 0 2 2 2 2 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3 PF16746.5 EMC77836.1 - 0.00055 19.7 8.2 0.007 16.1 5.9 2.9 1 1 1 2 2 2 1 BAR domain of APPL family zf-met PF12874.7 EMC77837.1 - 1.2e-08 35.0 21.9 0.0025 18.2 0.1 5.5 6 0 0 6 6 6 3 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EMC77837.1 - 3.9e-06 27.2 44.4 0.0045 17.7 1.6 8.3 9 0 0 9 9 9 3 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC77837.1 - 2.5e-05 24.5 43.1 0.0039 17.6 2.3 7.5 6 1 0 6 6 6 4 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EMC77837.1 - 7.1e-05 23.0 22.4 0.012 15.9 1.3 4.5 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-C2H2_aberr PF17017.5 EMC77837.1 - 0.059 13.5 9.9 1.6 8.8 0.3 3.8 3 0 0 3 3 3 0 Aberrant zinc-finger zf-DNA_Pol PF08996.10 EMC77837.1 - 5.3 6.7 15.2 0.2 11.4 1.0 3.6 3 0 0 3 3 3 0 DNA Polymerase alpha zinc finger PWWP PF00855.17 EMC77838.1 - 0.00024 21.4 0.0 0.00024 21.4 0.0 2.4 2 1 0 2 2 2 1 PWWP domain Raftlin PF15250.6 EMC77838.1 - 4.2 6.0 12.2 5.5 5.6 12.2 1.0 1 0 0 1 1 1 0 Raftlin Pkinase PF00069.25 EMC77839.1 - 6.9e-59 199.4 0.0 1.5e-38 132.7 0.2 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMC77839.1 - 1.9e-30 106.1 0.0 2.6e-23 82.6 0.4 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EMC77839.1 - 0.00044 19.3 0.0 0.00087 18.3 0.0 1.5 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EMC77839.1 - 0.00071 19.6 0.1 0.0055 16.7 0.1 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 EMC77839.1 - 0.0025 17.5 0.1 0.33 10.5 0.0 3.0 3 0 0 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EMC77839.1 - 0.0071 15.7 0.1 0.014 14.7 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EMC77839.1 - 0.0084 15.4 0.0 0.029 13.7 0.0 1.8 2 0 0 2 2 2 1 Kinase-like ACBP PF00887.19 EMC77840.1 - 2.4e-23 82.2 0.0 5.1e-23 81.1 0.0 1.6 1 0 0 1 1 1 1 Acyl CoA binding protein RINT1_TIP1 PF04437.13 EMC77840.1 - 0.065 12.1 0.0 0.1 11.5 0.0 1.2 1 0 0 1 1 1 0 RINT-1 / TIP-1 family DALR_1 PF05746.15 EMC77840.1 - 0.1 12.7 0.4 0.73 10.0 0.0 2.4 1 1 1 2 2 2 0 DALR anticodon binding domain Abi_HHR PF07815.14 EMC77841.1 - 1.5e-35 121.1 0.6 3.1e-35 120.1 0.6 1.5 1 0 0 1 1 1 1 Abl-interactor HHR SH3_1 PF00018.28 EMC77841.1 - 2e-16 59.3 0.1 3.3e-16 58.6 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC77841.1 - 6.6e-15 54.7 0.3 1.5e-14 53.6 0.1 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EMC77841.1 - 5.6e-11 42.0 0.1 9.2e-11 41.3 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain ATP-synt_ab_Xtn PF16886.5 EMC77841.1 - 0.12 12.2 0.0 0.75 9.7 0.0 2.0 2 0 0 2 2 2 0 ATPsynthase alpha/beta subunit N-term extension polyprenyl_synt PF00348.17 EMC77842.1 - 8.4e-71 238.0 0.0 1e-70 237.7 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase HEPPP_synt_1 PF07307.11 EMC77842.1 - 0.0012 18.6 0.2 0.0019 17.8 0.2 1.3 1 0 0 1 1 1 1 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 UPF0061 PF02696.14 EMC77843.1 - 2.9e-91 306.6 0.0 3.4e-91 306.4 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family UPF0061 PF02696.14 EMC77844.1 - 0.00015 20.7 0.1 0.00018 20.4 0.1 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family STN1_2 PF09170.10 EMC77844.1 - 0.046 13.9 0.0 0.052 13.8 0.0 1.0 1 0 0 1 1 1 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 SHR-BD PF06650.12 EMC77844.1 - 0.066 12.6 0.0 0.066 12.6 0.0 1.1 1 0 0 1 1 1 0 SHR-binding domain of vacuolar-sorting associated protein 13 RA PF00788.23 EMC77845.1 - 1.9e-13 50.9 1.3 6.8e-13 49.1 0.7 2.2 1 1 1 2 2 2 1 Ras association (RalGDS/AF-6) domain PH PF00169.29 EMC77845.1 - 7.3e-13 48.9 0.2 1.8e-12 47.6 0.2 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EMC77845.1 - 0.004 17.6 0.2 0.013 15.9 0.2 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain TNFR_c6 PF00020.18 EMC77846.1 - 1.5e-06 28.5 10.1 3.3e-06 27.4 10.1 1.6 1 0 0 1 1 1 1 TNFR/NGFR cysteine-rich region EGF_CA PF07645.15 EMC77846.1 - 0.0084 16.3 0.2 0.0084 16.3 0.2 2.7 2 1 0 2 2 2 1 Calcium-binding EGF domain Aspzincin_M35 PF14521.6 EMC77846.1 - 0.09 13.3 1.0 0.12 13.0 1.0 1.2 1 0 0 1 1 1 0 Lysine-specific metallo-endopeptidase Pyridoxal_deC PF00282.19 EMC77847.1 - 2.8e-136 454.1 0.0 3.4e-136 453.9 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EMC77847.1 - 4.9e-05 22.4 0.0 0.0003 19.9 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EMC77847.1 - 0.00099 18.5 0.0 0.0019 17.6 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase 7tm_3 PF00003.22 EMC77848.1 - 4.4e-18 65.9 8.4 5.7e-18 65.5 8.4 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Cys_rich_CPCC PF14206.6 EMC77848.1 - 0.079 12.8 0.1 19 5.2 0.0 3.0 3 0 0 3 3 3 0 Cysteine-rich CPCC MFS_1_like PF12832.7 EMC77848.1 - 1.7 7.4 5.2 2.6 6.8 5.2 1.2 1 0 0 1 1 1 0 MFS_1 like family TED_complement PF07678.14 EMC77851.1 - 5e-76 255.7 0.6 3.6e-74 249.6 0.6 2.2 1 1 0 1 1 1 1 A-macroglobulin TED domain A2M_recep PF07677.14 EMC77851.1 - 2.4e-30 105.1 0.1 2.5e-29 101.8 0.0 2.7 2 0 0 2 2 2 1 A-macroglobulin receptor binding domain A2M PF00207.22 EMC77851.1 - 4.3e-30 103.4 0.2 2.1e-29 101.2 0.1 2.4 2 0 0 2 2 2 1 Alpha-2-macroglobulin family MG4 PF17789.1 EMC77851.1 - 2.4e-29 101.3 0.7 1.3e-28 98.9 0.1 2.6 2 0 0 2 2 2 1 Macroglobulin domain MG4 A2M_BRD PF07703.14 EMC77851.1 - 5.1e-28 98.2 2.2 2.7e-27 95.8 0.0 3.3 4 0 0 4 4 4 1 Alpha-2-macroglobulin bait region domain NTR PF01759.21 EMC77851.1 - 3.1e-26 91.2 0.2 1.8e-25 88.8 0.0 2.3 2 0 0 2 2 2 1 UNC-6/NTR/C345C module MG1 PF17790.1 EMC77851.1 - 2.5e-21 76.0 0.4 1.1e-20 73.9 0.4 2.3 1 0 0 1 1 1 1 Macroglobulin domain MG1 MG2 PF01835.19 EMC77851.1 - 6e-16 58.7 0.0 5e-15 55.7 0.0 2.6 2 0 0 2 2 2 1 MG2 domain MG3 PF17791.1 EMC77851.1 - 8.5e-16 58.0 0.0 2.7e-15 56.4 0.0 2.0 1 0 0 1 1 1 1 Macroglobulin domain MG3 ANATO PF01821.18 EMC77851.1 - 1.4e-14 54.6 7.4 4.4e-14 53.0 7.4 1.9 1 0 0 1 1 1 1 Anaphylotoxin-like domain Transglut_C PF00927.22 EMC77851.1 - 0.051 13.7 0.0 0.16 12.1 0.0 1.9 1 0 0 1 1 1 0 Transglutaminase family, C-terminal ig like domain FAD_binding_9 PF08021.11 EMC77851.1 - 0.069 13.4 0.0 0.22 11.7 0.0 1.8 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain DUF11 PF01345.18 EMC77851.1 - 0.2 12.0 1.7 2.3 8.6 0.3 3.2 2 1 0 2 2 2 0 Domain of unknown function DUF11 RskA PF10099.9 EMC77853.1 - 0.041 14.2 0.1 0.054 13.8 0.1 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Lectin_C PF00059.21 EMC77853.1 - 0.055 14.2 0.0 0.11 13.3 0.0 1.4 1 0 0 1 1 1 0 Lectin C-type domain Chordopox_A33R PF05966.12 EMC77853.1 - 0.1 11.9 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Chordopoxvirus A33R protein Cytochrom_B562 PF07361.11 EMC77853.1 - 0.12 13.1 0.3 0.19 12.4 0.3 1.2 1 0 0 1 1 1 0 Cytochrome b562 UL45 PF05473.12 EMC77853.1 - 0.32 10.6 1.0 0.55 9.8 0.1 1.7 1 1 2 3 3 3 0 UL45 protein, carbohydrate-binding C-type lectin-like Gar1 PF04410.14 EMC77854.1 - 4.3e-45 153.2 0.2 5.6e-45 152.9 0.2 1.1 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region Zip PF02535.22 EMC77854.1 - 0.27 10.4 0.1 0.31 10.2 0.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter 7tm_1 PF00001.21 EMC77855.1 - 2e-39 135.5 13.5 2.4e-39 135.3 13.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC77855.1 - 2.2e-07 30.5 22.4 3.7e-05 23.2 14.0 2.4 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx Tma16 PF11176.8 EMC77856.1 - 6.8e-46 155.8 6.0 6.8e-46 155.8 6.0 1.5 2 0 0 2 2 2 1 Translation machinery-associated protein 16 DapB_C PF05173.14 EMC77856.1 - 0.076 13.1 0.2 0.13 12.3 0.2 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, C-terminus Ion_trans_N PF08412.10 EMC77856.1 - 1.5 8.5 0.0 1.5 8.5 0.0 3.2 4 0 0 4 4 4 0 Ion transport protein N-terminal RINGv PF12906.7 EMC77857.1 - 1.7e-15 56.9 15.7 1.7e-15 56.9 15.7 1.9 2 0 0 2 2 2 1 RING-variant domain Phage_Gp19 PF09355.10 EMC77857.1 - 0.2 12.1 0.6 0.4 11.1 0.2 1.7 2 0 0 2 2 2 0 Phage protein Gp19/Gp15/Gp42 ING PF12998.7 EMC77858.1 - 5e-16 59.1 2.8 9.9e-16 58.2 2.8 1.5 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding Pet100 PF09803.9 EMC77858.1 - 0.04 14.4 1.2 0.099 13.2 1.2 1.7 1 0 0 1 1 1 0 Pet100 SAICAR_synt PF01259.18 EMC77858.1 - 0.069 12.7 1.0 0.1 12.2 1.0 1.2 1 0 0 1 1 1 0 SAICAR synthetase UPF0242 PF06785.11 EMC77858.1 - 0.82 9.8 5.7 1.3 9.1 5.7 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Tetraspanin PF00335.20 EMC77859.1 - 6.7e-33 114.3 7.4 8e-33 114.1 7.4 1.1 1 0 0 1 1 1 1 Tetraspanin family SUR7 PF06687.12 EMC77859.1 - 0.036 13.7 2.4 0.11 12.1 2.4 1.7 2 0 0 2 2 2 0 SUR7/PalI family MscS_TM PF12794.7 EMC77859.1 - 1.6 7.5 7.7 0.42 9.4 4.5 1.6 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 DUF3399 PF11879.8 EMC77860.1 - 3.8e-10 40.0 2.3 3.8e-10 40.0 2.3 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3399) Ank_5 PF13857.6 EMC77861.1 - 4.8e-26 90.5 8.1 1.7e-09 37.8 0.1 3.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC77861.1 - 6.9e-26 90.6 2.3 4.8e-13 49.5 0.2 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EMC77861.1 - 2e-25 88.0 3.8 1.2e-05 25.5 0.0 4.0 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.6 EMC77861.1 - 2.3e-20 72.7 1.5 6e-07 29.9 0.0 3.9 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC77861.1 - 5.6e-20 69.3 1.7 0.00093 19.5 0.0 4.1 4 0 0 4 4 4 4 Ankyrin repeat CFTR_R PF14396.6 EMC77862.1 - 3.1e-102 340.6 1.7 3.1e-102 340.6 1.7 1.8 2 0 0 2 2 2 1 Cystic fibrosis TM conductance regulator (CFTR), regulator domain ABC_membrane PF00664.23 EMC77862.1 - 4.5e-95 318.4 40.1 1.8e-50 172.1 17.2 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EMC77862.1 - 2.4e-55 186.8 0.0 2.1e-30 106.0 0.0 2.8 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EMC77862.1 - 6.8e-07 29.4 0.5 0.15 11.9 0.0 3.7 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EMC77862.1 - 1.3e-06 28.1 0.0 0.023 14.1 0.0 3.0 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain T2SSE PF00437.20 EMC77862.1 - 2.2e-06 26.9 0.1 0.026 13.6 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein RsgA_GTPase PF03193.16 EMC77862.1 - 1.3e-05 25.1 0.3 0.026 14.4 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EMC77862.1 - 2.5e-05 23.9 1.1 0.0089 15.7 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EMC77862.1 - 0.00043 20.7 0.0 1.2 9.5 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.17 EMC77862.1 - 0.00045 20.4 1.1 0.31 11.1 0.1 2.7 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_23 PF13476.6 EMC77862.1 - 0.00099 19.7 7.2 0.53 10.8 0.1 3.7 3 0 0 3 3 3 2 AAA domain NTPase_1 PF03266.15 EMC77862.1 - 0.0014 18.5 0.4 0.2 11.5 0.0 3.1 3 0 0 3 3 3 1 NTPase NACHT PF05729.12 EMC77862.1 - 0.0025 17.7 0.5 2.2 8.2 0.1 2.8 2 0 0 2 2 2 2 NACHT domain MeaB PF03308.16 EMC77862.1 - 0.0053 15.8 0.2 0.11 11.5 0.1 2.4 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 EMC77862.1 - 0.0098 16.0 0.1 1.1 9.3 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EMC77862.1 - 0.012 15.9 0.5 8.8 6.6 0.1 3.0 3 0 0 3 3 2 0 AAA domain NB-ARC PF00931.22 EMC77862.1 - 0.017 14.3 0.5 0.78 8.9 0.1 2.7 3 0 0 3 3 2 0 NB-ARC domain Zeta_toxin PF06414.12 EMC77862.1 - 0.02 14.2 0.4 0.73 9.1 0.1 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.6 EMC77862.1 - 0.02 14.6 0.0 1.5 8.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EMC77862.1 - 0.039 13.5 0.1 7.2 6.1 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region TsaE PF02367.17 EMC77862.1 - 0.054 13.5 0.2 8.6 6.4 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DEAD PF00270.29 EMC77862.1 - 0.13 12.0 0.1 19 4.9 0.0 2.8 2 1 0 2 2 2 0 DEAD/DEAH box helicase RNA_helicase PF00910.22 EMC77862.1 - 0.13 12.7 0.0 24 5.4 0.0 2.6 2 0 0 2 2 2 0 RNA helicase cobW PF02492.19 EMC77862.1 - 0.13 11.8 1.4 5.9 6.4 0.2 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TrwB_AAD_bind PF10412.9 EMC77862.1 - 0.15 10.9 0.9 3.6 6.4 0.1 2.7 2 1 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_19 PF13245.6 EMC77862.1 - 0.18 12.2 0.0 20 5.5 0.0 2.8 2 1 0 2 2 2 0 AAA domain MobB PF03205.14 EMC77862.1 - 0.24 11.3 1.3 34 4.4 0.1 3.2 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B Ank_2 PF12796.7 EMC77863.1 - 1.2e-25 89.9 0.5 8.2e-15 55.2 0.1 3.7 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 EMC77863.1 - 1.2e-24 85.6 0.7 6.5e-07 29.5 0.0 5.5 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 EMC77863.1 - 1e-21 76.7 0.2 2.1e-11 43.8 0.0 4.4 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC77863.1 - 2.8e-20 72.4 0.3 1.4e-06 28.7 0.0 3.8 1 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC77863.1 - 1.6e-19 67.9 0.8 0.00025 21.3 0.0 5.2 5 0 0 5 5 5 4 Ankyrin repeat SAM_1 PF00536.30 EMC77863.1 - 1.2e-08 35.3 0.3 2.5e-08 34.2 0.3 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC77863.1 - 2.2e-08 34.1 0.2 4.9e-08 33.0 0.2 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Sec34 PF04136.15 EMC77863.1 - 0.018 14.9 1.4 0.47 10.3 0.4 2.4 2 0 0 2 2 2 0 Sec34-like family KASH_CCD PF14662.6 EMC77863.1 - 0.36 10.6 0.1 0.36 10.6 0.1 2.8 3 0 0 3 3 3 0 Coiled-coil region of CCDC155 or KASH Collagen PF01391.18 EMC77864.1 - 2.1e-26 91.4 93.5 7.6e-10 38.4 32.6 3.1 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) UQ_con PF00179.26 EMC77866.1 - 1.5e-10 40.9 0.0 5.4e-10 39.1 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EMC77866.1 - 0.0013 18.4 0.0 0.0025 17.5 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic E2 family B Josephin PF02099.17 EMC77866.1 - 0.0045 17.1 0.3 0.0059 16.7 0.3 1.4 1 1 0 1 1 1 1 Josephin Neur_chan_LBD PF02931.23 EMC77867.1 - 7.4e-33 113.8 0.0 8.5e-33 113.6 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC77867.1 - 2.3e-26 93.3 12.2 3e-26 92.9 12.2 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF2417 PF10329.9 EMC77867.1 - 0.038 13.4 3.5 0.05 13.0 3.5 1.1 1 0 0 1 1 1 0 Region of unknown function (DUF2417) GDA1_CD39 PF01150.17 EMC77869.1 - 2e-94 316.7 0.0 2.6e-94 316.3 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family TMEM141 PF15110.6 EMC77870.1 - 3.1e-15 56.5 0.1 3.9e-15 56.2 0.1 1.1 1 0 0 1 1 1 1 TMEM141 protein family PAXX PF15384.6 EMC77871.1 - 1.3e-21 77.2 0.6 1.4e-21 77.1 0.6 1.0 1 0 0 1 1 1 1 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 GST_C_2 PF13410.6 EMC77872.1 - 4.2e-08 33.1 0.0 5.1e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EMC77872.1 - 0.002 18.3 0.0 0.0026 18.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain ABC2_membrane_3 PF12698.7 EMC77873.1 - 3.5e-59 200.6 49.8 1e-43 149.8 12.8 3.5 4 1 0 4 4 4 2 ABC-2 family transporter protein ABC_tran PF00005.27 EMC77873.1 - 7.9e-58 194.8 0.0 1.2e-29 103.5 0.0 2.8 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 EMC77873.1 - 5.8e-19 69.0 0.4 1.3e-06 28.4 0.0 4.5 3 1 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EMC77873.1 - 0.00099 18.9 0.0 2 8.0 0.0 2.7 3 0 0 3 3 3 2 AAA ATPase domain DUF4162 PF13732.6 EMC77873.1 - 0.0013 19.5 1.0 0.61 10.8 0.2 2.9 2 0 0 2 2 2 2 Domain of unknown function (DUF4162) AAA_23 PF13476.6 EMC77873.1 - 0.012 16.2 3.4 0.54 10.7 0.1 2.7 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 EMC77873.1 - 0.035 13.7 3.1 1.9 8.1 0.1 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain RsgA_GTPase PF03193.16 EMC77873.1 - 0.16 11.9 0.3 2.2 8.2 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase SbcCD_C PF13558.6 EMC77873.1 - 0.16 12.2 0.0 27 5.1 0.0 3.2 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 EMC77873.1 - 0.4 10.5 1.7 5.6 6.8 0.1 2.7 3 0 0 3 3 3 0 P-loop containing region of AAA domain Glyco_transf_10 PF00852.19 EMC77874.1 - 1.9e-57 193.9 0.6 2.4e-57 193.5 0.6 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 EMC77874.1 - 2e-32 112.0 0.0 3.7e-32 111.1 0.0 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal mIF3 PF14877.6 EMC77874.1 - 0.072 12.8 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial translation initiation factor Pou PF00157.17 EMC77875.1 - 3.3e-32 110.3 0.9 7.6e-32 109.1 0.2 1.9 2 0 0 2 2 2 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 EMC77875.1 - 1.2e-18 66.7 0.3 2.3e-18 65.8 0.3 1.5 1 0 0 1 1 1 1 Homeodomain DUF2497 PF10691.9 EMC77875.1 - 0.042 14.3 0.2 14 6.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2497) Homeobox_KN PF05920.11 EMC77875.1 - 0.07 13.0 0.1 0.16 11.9 0.1 1.6 1 0 0 1 1 1 0 Homeobox KN domain NPDC1 PF06809.11 EMC77876.1 - 3e-59 200.8 0.4 3.2e-59 200.7 0.4 1.0 1 0 0 1 1 1 1 Neural proliferation differentiation control-1 protein (NPDC1) FAM163 PF15069.6 EMC77876.1 - 0.65 10.4 3.5 1.1 9.7 3.5 1.7 1 1 0 1 1 1 0 FAM163 family 7tm_4 PF13853.6 EMC77877.1 - 5.3e-50 170.7 13.0 6.3e-50 170.5 13.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC77877.1 - 4.7e-29 101.5 14.2 1.2e-28 100.2 14.2 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC77877.1 - 0.00072 19.3 7.8 0.0014 18.3 7.3 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF1345 PF07077.11 EMC77877.1 - 0.2 11.4 4.1 0.35 10.6 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1345) Lipocalin PF00061.23 EMC77878.1 - 0.00024 21.3 0.0 0.00025 21.2 0.0 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family DUF4926 PF16277.5 EMC77878.1 - 0.03 13.7 0.1 0.8 9.1 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4926) Lipocalin PF00061.23 EMC77880.1 - 1.7e-32 112.6 0.2 6.5e-17 62.1 0.2 2.0 2 0 0 2 2 2 2 Lipocalin / cytosolic fatty-acid binding protein family Triabin PF03973.13 EMC77880.1 - 0.007 16.2 0.0 0.017 15.0 0.0 1.6 1 0 0 1 1 1 1 Triabin Lipocalin_2 PF08212.12 EMC77880.1 - 0.025 14.5 0.1 2.5 8.0 0.0 2.2 2 0 0 2 2 2 0 Lipocalin-like domain NMDAR2_C PF10565.9 EMC77880.1 - 0.12 11.2 0.0 0.16 10.8 0.0 1.1 1 0 0 1 1 1 0 N-methyl D-aspartate receptor 2B3 C-terminus Lipocalin PF00061.23 EMC77881.1 - 1.6e-16 60.8 0.0 1.9e-16 60.6 0.0 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family NDUFA12 PF05071.16 EMC77882.1 - 9.5e-30 103.3 4.6 1.2e-29 103.0 4.6 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 Hormone_recep PF00104.30 EMC77883.1 - 5.8e-44 150.1 0.9 8.9e-44 149.5 0.2 1.7 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 EMC77883.1 - 2e-31 108.3 15.6 4.6e-31 107.1 15.6 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) DUF2318 PF10080.9 EMC77883.1 - 0.045 13.9 0.9 0.045 13.9 0.9 2.4 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) RhoGEF PF00621.20 EMC77884.1 - 2.3e-37 129.0 2.0 8.2e-37 127.2 2.0 2.1 1 0 0 1 1 1 1 RhoGEF domain FYVE PF01363.21 EMC77884.1 - 3.4e-20 72.0 10.2 7.6e-20 70.8 10.2 1.6 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 EMC77884.1 - 8.4e-18 64.8 2.0 2e-08 34.7 0.0 3.1 3 0 0 3 3 3 2 PH domain PH_13 PF16652.5 EMC77884.1 - 1.2e-05 25.1 3.6 0.0008 19.3 2.5 3.0 2 1 0 2 2 2 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 EMC77884.1 - 3.3e-05 23.9 1.0 8.6e-05 22.5 0.1 2.0 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 EMC77884.1 - 0.00076 19.9 3.4 0.12 12.9 0.1 4.1 4 0 0 4 4 4 1 Pleckstrin homology domain FYVE_2 PF02318.16 EMC77884.1 - 0.0017 18.6 7.9 0.0017 18.6 7.9 2.2 2 0 0 2 2 2 1 FYVE-type zinc finger PH_9 PF15410.6 EMC77884.1 - 0.54 10.6 2.2 7.8 6.9 0.8 3.3 2 1 0 2 2 2 0 Pleckstrin homology domain zf-SNAP50_C PF12251.8 EMC77884.1 - 1.8 8.2 8.9 3.4 7.3 8.0 1.9 1 1 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal Vezatin PF12632.7 EMC77885.1 - 8.4e-93 310.8 0.9 8.4e-93 310.8 0.9 2.3 2 0 0 2 2 2 1 Mysoin-binding motif of peroxisomes RNase_3_N PF18497.1 EMC77885.1 - 0.0083 16.3 0.0 5.6 7.2 0.0 2.9 2 0 0 2 2 2 2 Ribonuclease III N-terminal domain YwiC PF14256.6 EMC77885.1 - 0.099 13.0 2.7 0.17 12.2 2.7 1.3 1 0 0 1 1 1 0 YwiC-like protein ATPase_2 PF01637.18 EMC77885.1 - 0.79 9.6 4.3 0.21 11.5 0.2 2.0 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea DUF2175 PF09943.9 EMC77885.1 - 2.2 8.6 6.4 2.6 8.4 0.8 3.2 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) KRAB PF01352.27 EMC77886.1 - 3.8e-15 55.3 0.5 7.8e-15 54.3 0.5 1.5 1 1 0 1 1 1 1 KRAB box DUF3318 PF11780.8 EMC77886.1 - 0.04 13.9 0.0 0.04 13.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3318) Recep_L_domain PF01030.24 EMC77887.1 - 5.5e-29 100.5 0.0 6.5e-29 100.3 0.0 1.1 1 0 0 1 1 1 1 Receptor L domain CDH PF02611.15 EMC77887.1 - 0.016 14.8 0.0 0.02 14.5 0.0 1.1 1 0 0 1 1 1 0 CDP-diacylglycerol pyrophosphatase Pkinase_Tyr PF07714.17 EMC77888.1 - 1.1e-23 83.8 0.0 2.3e-23 82.8 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase GF_recep_IV PF14843.6 EMC77888.1 - 1.6e-11 44.1 4.3 2.3e-11 43.6 4.3 1.2 1 0 0 1 1 1 1 Growth factor receptor domain IV Pkinase PF00069.25 EMC77888.1 - 2.2e-10 40.4 0.0 4.3e-10 39.4 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Protocadherin PF08374.11 EMC77888.1 - 0.00074 19.6 0.0 0.00086 19.3 0.0 1.2 1 0 0 1 1 1 1 Protocadherin Adeno_E3_CR2 PF02439.15 EMC77888.1 - 0.00098 18.8 0.1 0.0017 18.0 0.1 1.4 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 EphA2_TM PF14575.6 EMC77888.1 - 0.0015 19.4 0.1 0.003 18.4 0.1 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain DUF4381 PF14316.6 EMC77888.1 - 0.011 16.0 0.1 0.017 15.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Herpes_gE PF02480.16 EMC77888.1 - 0.022 13.5 0.0 0.029 13.1 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E TMEM154 PF15102.6 EMC77888.1 - 0.028 14.3 0.0 0.043 13.7 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family CD34_antigen PF06365.12 EMC77888.1 - 0.04 13.5 0.1 0.057 13.0 0.1 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family TMEM51 PF15345.6 EMC77888.1 - 0.13 12.0 0.0 0.53 10.1 0.0 1.9 2 0 0 2 2 2 0 Transmembrane protein 51 Syndecan PF01034.20 EMC77888.1 - 0.28 11.1 1.9 0.43 10.5 0.7 1.8 2 0 0 2 2 2 0 Syndecan domain Antistasin PF02822.14 EMC77888.1 - 0.97 10.1 9.1 4.1 8.1 0.0 3.1 2 1 0 2 2 2 0 Antistasin family Rdx PF10262.9 EMC77889.1 - 2.4e-14 53.3 0.0 3.1e-14 52.9 0.0 1.1 1 0 0 1 1 1 1 Rdx family adh_short PF00106.25 EMC77890.1 - 5.9e-28 97.6 0.0 7.8e-28 97.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC77890.1 - 5.6e-17 62.1 0.0 8.6e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC77890.1 - 0.16 11.9 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 KR domain zf-H2C2_2 PF13465.6 EMC77891.1 - 2.1e-24 84.8 28.1 6.1e-07 29.6 3.8 5.9 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.26 EMC77891.1 - 7.7e-16 57.6 38.5 9.9e-06 25.7 0.4 6.6 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC77891.1 - 1.6e-11 44.0 39.0 0.00025 21.6 0.3 6.7 6 0 0 6 6 6 5 C2H2-type zinc finger zf-H2C2_5 PF13909.6 EMC77891.1 - 0.0016 18.1 32.4 0.0036 17.0 0.1 5.6 5 0 0 5 5 5 2 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.5 EMC77891.1 - 0.0056 16.4 0.2 0.0056 16.4 0.2 4.5 5 1 0 5 5 4 1 zinc-finger C2H2-type GAGA PF09237.11 EMC77891.1 - 0.066 13.0 2.2 0.14 12.0 0.1 2.6 1 1 0 2 2 2 0 GAGA factor DUF3268 PF11672.8 EMC77891.1 - 0.067 13.5 6.0 0.26 11.6 0.3 2.9 3 0 0 3 3 2 0 zinc-finger-containing domain zf-C2H2_6 PF13912.6 EMC77891.1 - 0.15 12.1 38.6 0.65 10.1 0.1 6.5 6 0 0 6 6 6 0 C2H2-type zinc finger zf-C2HE PF16278.5 EMC77891.1 - 0.53 10.8 18.1 1.3 9.6 1.7 4.5 2 1 2 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger AKAP95 PF04988.12 EMC77891.1 - 1.6 8.9 7.2 1.1 9.5 0.2 2.7 2 0 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) zf-RING_7 PF02591.15 EMC77891.1 - 2.9 8.2 8.2 40 4.5 0.1 4.0 4 0 0 4 4 4 0 C4-type zinc ribbon domain zf-C2H2_jaz PF12171.8 EMC77891.1 - 4.9 7.6 24.9 3 8.2 0.3 5.5 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding Sp38 PF07354.12 EMC77892.1 - 2.1e-79 265.1 10.5 2.8e-79 264.6 10.5 1.2 1 0 0 1 1 1 1 Zona-pellucida-binding protein (Sp38) LRR_8 PF13855.6 EMC77893.1 - 2.1e-17 62.6 4.1 3.5e-11 42.7 0.0 2.6 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EMC77893.1 - 3.8e-07 30.3 4.2 0.069 13.6 0.1 3.4 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) DUF3700 PF12481.8 EMC77893.1 - 0.00038 20.0 0.0 0.00079 18.9 0.0 1.4 1 0 0 1 1 1 1 Aluminium induced protein LRR_1 PF00560.33 EMC77893.1 - 0.0034 17.7 7.5 0.66 10.7 0.4 4.6 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_6 PF13516.6 EMC77893.1 - 0.012 15.6 5.3 2.1 8.6 0.2 3.3 3 0 0 3 3 3 0 Leucine Rich repeat LRRNT PF01462.18 EMC77893.1 - 0.11 12.1 0.1 0.11 12.1 0.1 1.9 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain ORMDL PF04061.14 EMC77894.1 - 2.5e-54 182.7 4.6 2.9e-54 182.6 4.6 1.0 1 0 0 1 1 1 1 ORMDL family Gasdermin PF04598.12 EMC77895.1 - 1.2e-32 113.2 0.0 1.4e-32 113.1 0.0 1.0 1 0 0 1 1 1 1 Gasdermin pore forming domain APG5 PF04106.12 EMC77895.1 - 0.073 12.7 0.0 0.077 12.6 0.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg5 Gasdermin_C PF17708.1 EMC77896.1 - 1.8e-05 25.0 0.3 2.3e-05 24.6 0.3 1.1 1 0 0 1 1 1 1 Gasdermin PUB domain Rpn3_C PF08375.11 EMC77897.1 - 2.5e-28 98.3 2.1 2.5e-28 98.3 2.1 2.3 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 EMC77897.1 - 1.1e-24 86.9 0.0 3.7e-24 85.2 0.0 1.9 1 0 0 1 1 1 1 PCI domain CSN8_PSD8_EIF3K PF10075.9 EMC77897.1 - 0.022 14.8 0.1 0.071 13.1 0.0 1.9 2 0 0 2 2 2 0 CSN8/PSMD8/EIF3K family TPR_2 PF07719.17 EMC77897.1 - 0.084 13.0 1.7 0.51 10.6 0.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat GCSF PF16647.5 EMC77898.1 - 3.4e-20 72.4 0.1 3.8e-20 72.3 0.1 1.0 1 0 0 1 1 1 1 Granulocyte colony-stimulating factor IL6 PF00489.17 EMC77898.1 - 0.049 13.2 0.0 0.056 13.0 0.0 1.1 1 0 0 1 1 1 0 Interleukin-6/G-CSF/MGF family zf-C4 PF00105.18 EMC77900.1 - 1.8e-32 111.6 14.4 2.1e-32 111.4 14.4 1.0 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Fer4_6 PF12837.7 EMC77900.1 - 0.13 12.4 0.6 0.13 12.4 0.6 3.2 4 0 0 4 4 4 0 4Fe-4S binding domain ZF-HD_dimer PF04770.12 EMC77900.1 - 2 8.8 14.0 0.88 10.0 1.6 3.1 1 1 2 3 3 3 0 ZF-HD protein dimerisation region Btz PF09405.10 EMC77902.1 - 1.2e-14 54.6 3.3 1.5e-14 54.3 1.6 2.1 2 0 0 2 2 2 1 CASC3/Barentsz eIF4AIII binding PAX PF00292.18 EMC77903.1 - 5.5e-75 249.3 0.9 8e-75 248.7 0.9 1.2 1 0 0 1 1 1 1 'Paired box' domain Pax7 PF12360.8 EMC77903.1 - 1.8e-25 88.8 6.8 3.7e-25 87.8 6.8 1.6 1 0 0 1 1 1 1 Paired box protein 7 Homeodomain PF00046.29 EMC77903.1 - 8e-23 80.1 6.9 1.4e-22 79.3 6.9 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC77903.1 - 0.00033 20.5 1.4 0.00056 19.7 0.7 1.8 2 0 0 2 2 2 1 Homeobox KN domain HTH_23 PF13384.6 EMC77903.1 - 0.00036 20.2 2.9 0.0012 18.6 0.1 2.5 3 0 0 3 3 3 1 Homeodomain-like domain HTH_Tnp_IS1 PF12759.7 EMC77903.1 - 0.16 11.6 0.0 0.34 10.6 0.0 1.4 1 0 0 1 1 1 0 InsA C-terminal domain Pkinase_Tyr PF07714.17 EMC77904.1 - 3e-96 321.7 0.0 4.4e-96 321.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.19 EMC77904.1 - 4.3e-74 248.4 0.0 8.3e-74 247.5 0.0 1.5 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.25 EMC77904.1 - 2.1e-45 155.1 0.0 3.4e-45 154.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 EMC77904.1 - 3.4e-34 117.0 0.5 1e-16 61.0 0.1 3.0 3 0 0 3 3 2 2 Fibronectin type III domain EphA2_TM PF14575.6 EMC77904.1 - 6.5e-25 87.8 0.1 1.3e-24 86.8 0.1 1.6 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_2 PF07647.17 EMC77904.1 - 8.8e-21 73.8 0.0 1.7e-20 72.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EMC77904.1 - 2.8e-18 66.1 0.0 5.1e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pur_ac_phosph_N PF16656.5 EMC77904.1 - 8.3e-06 26.3 0.4 0.0093 16.5 0.0 2.8 1 1 1 2 2 2 2 Purple acid Phosphatase, N-terminal domain Ephrin_rec_like PF07699.13 EMC77904.1 - 2.1e-05 24.2 5.3 2.1e-05 24.2 5.3 3.1 2 2 1 3 3 3 1 Putative ephrin-receptor like fn3_2 PF16893.5 EMC77904.1 - 0.00052 20.1 0.2 1.4 9.2 0.0 3.0 3 0 0 3 3 3 2 Fibronectin type III domain DUF2369 PF10179.9 EMC77904.1 - 0.0041 17.5 0.1 0.016 15.6 0.0 1.9 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.10 EMC77904.1 - 0.0081 16.5 0.4 1.8 8.9 0.0 3.5 4 0 0 4 4 4 1 Interferon-alpha/beta receptor, fibronectin type III Haspin_kinase PF12330.8 EMC77904.1 - 0.021 13.8 0.0 0.035 13.1 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Tissue_fac PF01108.17 EMC77904.1 - 0.037 13.9 0.1 0.28 11.1 0.0 2.2 2 0 0 2 2 2 0 Tissue factor SusE PF14292.6 EMC77904.1 - 0.09 13.0 0.0 2.5 8.4 0.0 2.5 2 1 0 2 2 2 0 SusE outer membrane protein Kdo PF06293.14 EMC77904.1 - 0.099 12.0 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family His_Phos_2 PF00328.22 EMC77905.1 - 7.4e-31 107.9 0.0 2e-30 106.4 0.0 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) zf-C3HC4_5 PF17121.5 EMC77905.1 - 0.12 12.3 2.3 0.19 11.7 0.2 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF4279 PF14106.6 EMC77906.1 - 0.034 14.3 0.0 0.089 13.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4279) C1q PF00386.21 EMC77908.1 - 0.0046 17.2 0.2 0.0099 16.1 0.2 1.7 1 1 0 1 1 1 1 C1q domain TNF PF00229.18 EMC77908.1 - 0.077 12.9 0.4 0.13 12.2 0.4 1.4 1 1 0 1 1 1 0 TNF(Tumour Necrosis Factor) family PP2C PF00481.21 EMC77909.1 - 3.1e-63 213.8 0.2 3.9e-63 213.5 0.2 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EMC77909.1 - 0.00012 21.7 0.0 0.00024 20.8 0.0 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C Mab-21 PF03281.14 EMC77910.1 - 4.9e-16 58.9 0.0 9e-16 58.0 0.0 1.3 1 0 0 1 1 1 1 Mab-21 protein EGF PF00008.27 EMC77911.1 - 8.5e-81 265.7 211.2 4.4e-08 33.3 10.7 14.7 14 0 0 14 14 14 14 EGF-like domain hEGF PF12661.7 EMC77911.1 - 2e-46 155.1 173.5 5.8e-06 26.7 4.7 16.1 14 1 0 14 14 14 12 Human growth factor-like EGF fn3 PF00041.21 EMC77911.1 - 8.3e-36 122.2 6.2 1.1e-12 48.1 0.8 3.4 3 0 0 3 3 3 3 Fibronectin type III domain NIDO PF06119.14 EMC77911.1 - 7.4e-27 94.1 0.1 1.7e-26 93.0 0.1 1.6 1 0 0 1 1 1 1 Nidogen-like EGF_2 PF07974.13 EMC77911.1 - 5.5e-22 77.8 239.1 0.00014 22.1 7.6 14.5 14 0 0 14 14 14 11 EGF-like domain EGF_CA PF07645.15 EMC77911.1 - 6.6e-21 74.3 202.6 1.5e-08 34.7 5.7 14.5 8 5 6 14 14 14 10 Calcium-binding EGF domain cEGF PF12662.7 EMC77911.1 - 0.00049 20.0 1.2 0.00049 20.0 1.2 17.0 17 3 0 17 17 17 5 Complement Clr-like EGF-like EGF_3 PF12947.7 EMC77911.1 - 0.0067 16.6 3.5 0.0067 16.6 3.5 14.7 14 0 0 14 14 14 6 EGF domain DUF2369 PF10179.9 EMC77911.1 - 0.091 13.1 1.0 7.6 7.0 0.1 2.9 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2369) Pkinase PF00069.25 EMC77913.1 - 2.1e-56 191.2 0.0 3.4e-56 190.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC77913.1 - 1.7e-23 83.3 0.0 3.3e-23 82.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PAS_9 PF13426.7 EMC77913.1 - 1.5e-13 50.8 0.0 0.00015 22.0 0.0 4.8 4 1 0 4 4 4 3 PAS domain PAS PF00989.25 EMC77913.1 - 3.7e-12 46.2 0.0 2.7e-06 27.3 0.0 3.6 3 0 0 3 3 3 3 PAS fold PAS_8 PF13188.7 EMC77913.1 - 6.5e-05 22.9 0.0 0.1 12.7 0.0 3.5 3 0 0 3 3 3 1 PAS domain Pkinase_fungal PF17667.1 EMC77913.1 - 0.0009 18.1 0.0 0.064 12.0 0.0 2.4 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EMC77913.1 - 0.0026 17.1 0.0 0.01 15.2 0.0 2.0 2 1 0 2 2 2 1 Kinase-like PAS_2 PF08446.11 EMC77913.1 - 0.018 15.7 0.7 0.57 10.9 0.0 3.0 2 0 0 2 2 2 0 PAS fold FlxA PF14282.6 EMC77913.1 - 0.78 9.8 10.0 0.16 12.0 0.8 2.8 2 0 0 2 2 2 0 FlxA-like protein Haspin_kinase PF12330.8 EMC77913.1 - 3 6.7 5.5 0.45 9.4 0.0 2.4 3 0 0 3 3 3 0 Haspin like kinase domain LRR_4 PF12799.7 EMC77914.1 - 9.7e-44 146.6 73.7 1.5e-09 38.0 2.5 7.2 1 1 8 10 10 10 10 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC77914.1 - 8.8e-29 100.2 34.1 1.3e-11 44.3 0.7 4.0 1 1 3 4 4 4 4 Leucine-rich repeat LRR_8 PF13855.6 EMC77914.1 - 1.8e-22 78.9 38.6 9.8e-08 31.7 7.5 6.3 2 2 3 6 6 6 6 Leucine rich repeat LRR_6 PF13516.6 EMC77914.1 - 0.0011 18.8 24.6 3.1 8.1 0.0 8.2 9 1 1 10 10 10 3 Leucine Rich repeat Ribosomal_L50 PF10501.9 EMC77914.1 - 0.0094 16.1 3.5 10 6.3 0.1 3.8 1 1 2 4 4 4 2 Ribosomal subunit 39S LRR_1 PF00560.33 EMC77914.1 - 0.022 15.3 32.9 1.9 9.4 0.4 9.0 9 1 0 9 9 9 0 Leucine Rich Repeat UB2H PF14814.6 EMC77914.1 - 0.17 11.9 8.1 21 5.2 0.1 5.4 2 2 4 7 7 7 0 Bifunctional transglycosylase second domain DUF1773 PF08593.10 EMC77914.1 - 4.6 8.4 0.0 4.6 8.4 0.0 5.8 6 1 1 7 7 7 0 Domain of unknown function Septin PF00735.18 EMC77915.1 - 2.5e-123 410.8 0.0 3.3e-123 410.5 0.0 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EMC77915.1 - 4e-08 33.3 0.0 1.2e-07 31.8 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC77915.1 - 0.00017 21.2 0.6 0.0043 16.6 0.0 2.5 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 EMC77915.1 - 0.0002 20.7 0.6 0.00047 19.6 0.0 1.8 2 0 0 2 2 2 1 AIG1 family Ras PF00071.22 EMC77915.1 - 0.00056 19.6 0.0 0.0014 18.3 0.0 1.7 1 0 0 1 1 1 1 Ras family Dynamin_N PF00350.23 EMC77915.1 - 0.0009 19.3 1.4 0.099 12.7 0.0 2.9 2 1 1 3 3 3 1 Dynamin family RsgA_GTPase PF03193.16 EMC77915.1 - 0.0014 18.5 0.3 0.0014 18.5 0.3 2.5 3 1 0 3 3 3 1 RsgA GTPase AAA_16 PF13191.6 EMC77915.1 - 0.0027 18.1 0.1 0.024 15.0 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain Roc PF08477.13 EMC77915.1 - 0.0048 17.1 0.0 0.0093 16.2 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 EMC77915.1 - 0.0058 16.9 0.2 0.026 14.8 0.0 2.2 2 1 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EMC77915.1 - 0.0087 16.6 0.1 0.023 15.2 0.0 1.8 2 0 0 2 2 2 1 ABC transporter AAA_29 PF13555.6 EMC77915.1 - 0.021 14.6 0.0 0.041 13.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 EMC77915.1 - 0.041 13.4 0.0 0.082 12.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region IIGP PF05049.13 EMC77915.1 - 0.11 11.5 0.1 0.55 9.2 0.0 1.9 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) Collagen PF01391.18 EMC77917.1 - 9.2e-18 63.8 125.7 0.0013 18.5 31.2 5.7 1 1 1 2 2 2 1 Collagen triple helix repeat (20 copies) Bcl-2 PF00452.19 EMC77918.1 - 1.1e-22 80.5 0.1 2.5e-22 79.4 0.1 1.6 2 0 0 2 2 2 1 Apoptosis regulator proteins, Bcl-2 family DAGK_cat PF00781.24 EMC77919.1 - 3.1e-27 94.7 0.0 4.8e-27 94.1 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain DAGK_acc PF00609.19 EMC77919.1 - 2e-23 83.5 0.2 3.8e-23 82.6 0.2 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain C1_1 PF00130.22 EMC77919.1 - 8.9e-23 79.9 29.2 3.5e-11 42.8 9.8 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 EMC77919.1 - 0.34 11.2 27.6 0.055 13.8 5.8 2.7 3 0 0 3 3 3 0 C1 domain PSI PF01437.25 EMC77920.1 - 7.7e-06 26.4 8.1 7.7e-06 26.4 8.1 1.7 2 0 0 2 2 2 1 Plexin repeat Shisa PF13908.6 EMC77920.1 - 0.00014 22.2 1.4 0.00015 22.0 1.4 1.2 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator EphA2_TM PF14575.6 EMC77920.1 - 0.006 17.4 0.4 0.011 16.6 0.4 1.4 1 1 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain DUF4834 PF16118.5 EMC77920.1 - 0.027 15.4 0.0 0.036 15.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TMEM51 PF15345.6 EMC77920.1 - 0.037 13.9 0.1 0.049 13.5 0.1 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 FAM176 PF14851.6 EMC77920.1 - 0.038 13.6 0.3 0.046 13.4 0.3 1.1 1 0 0 1 1 1 0 FAM176 family Prominin PF05478.11 EMC77920.1 - 0.049 11.6 3.6 0.06 11.3 3.6 1.1 1 0 0 1 1 1 0 Prominin ETRAMP PF09716.10 EMC77920.1 - 0.063 13.3 0.0 0.097 12.7 0.0 1.3 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Cadherin_C_2 PF16492.5 EMC77920.1 - 0.087 13.6 0.0 0.13 13.1 0.0 1.3 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal CCER1 PF15482.6 EMC77920.1 - 0.22 11.4 5.7 0.26 11.2 5.7 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 Rad60-SLD PF11976.8 EMC77921.1 - 1.3e-25 89.0 0.0 1.5e-25 88.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EMC77921.1 - 1.1e-12 47.5 0.1 1.3e-12 47.3 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin family UQ_con PF00179.26 EMC77922.1 - 2.8e-47 159.9 0.0 3.1e-47 159.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme EPTP PF03736.17 EMC77923.1 - 1.8e-92 303.1 29.7 2.8e-20 72.0 1.2 7.6 7 1 0 7 7 7 7 EPTP domain Laminin_G_3 PF13385.6 EMC77923.1 - 6.9e-06 26.3 0.0 2.9e-05 24.2 0.0 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 EMC77923.1 - 0.00014 22.5 0.0 0.00026 21.6 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 EMC77923.1 - 0.0028 17.9 0.0 0.0062 16.7 0.0 1.5 1 0 0 1 1 1 1 Laminin G domain DUF1794 PF08768.11 EMC77924.1 - 2.3e-30 105.5 0.0 6.7e-30 104.0 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1794) THAP PF05485.12 EMC77924.1 - 6.3e-12 46.3 0.6 6.3e-12 46.3 0.6 2.1 2 0 0 2 2 2 1 THAP domain DUF4201 PF13870.6 EMC77924.1 - 0.0017 18.1 0.6 0.0036 17.1 0.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) HrpB7 PF09486.10 EMC77924.1 - 0.0033 17.8 0.2 0.0096 16.3 0.2 1.8 1 0 0 1 1 1 1 Bacterial type III secretion protein (HrpB7) NPC1_N PF16414.5 EMC77924.1 - 0.017 14.7 0.7 0.03 13.9 0.7 1.4 1 0 0 1 1 1 0 Niemann-Pick C1 N terminus Csm1_N PF18504.1 EMC77924.1 - 0.21 11.9 2.3 0.96 9.8 2.3 2.1 1 0 0 1 1 1 0 Csm1 N-terminal domain Peptidase_C54 PF03416.19 EMC77925.1 - 3.4e-103 344.9 0.0 4.1e-103 344.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 Thymidylate_kin PF02223.17 EMC77926.1 - 2.9e-38 131.4 0.0 3.5e-38 131.1 0.0 1.1 1 0 0 1 1 1 1 Thymidylate kinase ING PF12998.7 EMC77927.1 - 1.7e-28 99.2 2.6 2.8e-28 98.5 2.6 1.3 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EMC77927.1 - 2.1e-06 27.5 8.1 4.4e-06 26.5 8.1 1.6 1 0 0 1 1 1 1 PHD-finger RRF PF01765.19 EMC77927.1 - 0.0016 18.4 2.1 0.0024 17.9 2.1 1.2 1 0 0 1 1 1 1 Ribosome recycling factor zf-HC5HC2H PF13771.6 EMC77927.1 - 0.022 15.0 1.7 0.032 14.5 0.4 1.9 2 0 0 2 2 2 0 PHD-like zinc-binding domain HD_3 PF13023.6 EMC77927.1 - 0.06 13.3 1.5 0.091 12.7 1.5 1.2 1 0 0 1 1 1 0 HD domain Spectrin_like PF18373.1 EMC77927.1 - 0.074 13.1 0.4 0.17 12.0 0.2 1.8 1 1 1 2 2 2 0 Spectrin like domain Spc7 PF08317.11 EMC77927.1 - 0.075 11.9 7.8 0.1 11.5 7.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein FAD-oxidase_C PF02913.19 EMC77928.1 - 4.8e-59 200.0 0.0 1.3e-57 195.3 0.0 2.1 1 1 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EMC77928.1 - 6.4e-35 119.9 0.2 1.1e-34 119.2 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain BNR_2 PF13088.6 EMC77929.1 - 2.1e-34 119.1 0.0 2.8e-30 105.6 0.0 2.1 2 0 0 2 2 2 2 BNR repeat-like domain BNR_3 PF13859.6 EMC77929.1 - 3.2e-06 26.6 0.0 4e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 EMC77929.1 - 2.2e-05 23.8 3.3 0.43 10.8 0.3 3.7 3 0 0 3 3 3 2 BNR/Asp-box repeat L6_membrane PF05805.12 EMC77930.1 - 3.8e-63 212.5 12.1 4.3e-63 212.3 12.1 1.0 1 0 0 1 1 1 1 L6 membrane protein UBX PF00789.20 EMC77931.1 - 6e-20 71.2 0.0 1.1e-19 70.4 0.0 1.5 1 0 0 1 1 1 1 UBX domain Thioredoxin_7 PF13899.6 EMC77931.1 - 2.1e-15 56.6 0.1 4e-15 55.8 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin-like UBA_4 PF14555.6 EMC77931.1 - 1.9e-07 30.8 0.2 6e-06 26.0 0.0 2.6 2 0 0 2 2 2 1 UBA-like domain UIM PF02809.20 EMC77931.1 - 0.023 14.6 3.6 0.078 12.9 3.6 2.0 1 0 0 1 1 1 0 Ubiquitin interaction motif Thioredox_DsbH PF03190.15 EMC77931.1 - 0.035 14.1 0.2 0.06 13.3 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF255 UBA PF00627.31 EMC77931.1 - 0.036 14.0 0.2 0.54 10.2 0.3 2.3 2 0 0 2 2 2 0 UBA/TS-N domain Thioredoxin_2 PF13098.6 EMC77931.1 - 0.12 12.8 0.1 0.27 11.7 0.1 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain zf-C3HC4 PF00097.25 EMC77932.1 - 7e-07 29.0 14.5 1.5e-06 27.9 14.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMC77932.1 - 7.3e-07 29.0 13.1 1.4e-06 28.0 13.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC77932.1 - 8.7e-07 28.7 10.2 8.7e-07 28.7 10.2 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EMC77932.1 - 1.3e-06 28.1 14.2 2.6e-06 27.2 14.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC77932.1 - 2.5e-06 27.4 11.2 7e-06 26.0 11.2 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMC77932.1 - 3.1e-06 27.1 12.3 6.4e-06 26.0 12.3 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EMC77932.1 - 7.1e-05 22.9 16.1 0.00016 21.8 16.1 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EMC77932.1 - 0.00076 19.8 16.9 0.0015 18.8 16.9 1.5 1 0 0 1 1 1 1 Ring finger domain Rox3 PF08633.10 EMC77932.1 - 0.0092 16.3 0.7 0.012 15.9 0.7 1.2 1 0 0 1 1 1 1 Rox3 mediator complex subunit U-box PF04564.15 EMC77932.1 - 0.012 15.7 0.0 0.029 14.6 0.0 1.6 1 0 0 1 1 1 0 U-box domain DUF3811 PF11656.8 EMC77932.1 - 0.017 15.5 3.9 0.03 14.7 3.9 1.4 1 0 0 1 1 1 0 YjbD family (DUF3811) zf-RING_4 PF14570.6 EMC77932.1 - 0.36 10.7 14.4 2.9 7.8 12.9 2.5 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain AAA_23 PF13476.6 EMC77932.1 - 1.5 9.2 8.8 2 8.9 8.8 1.2 1 0 0 1 1 1 0 AAA domain HSP70 PF00012.20 EMC77932.1 - 1.9 6.5 5.8 2.3 6.3 5.8 1.1 1 0 0 1 1 1 0 Hsp70 protein YlqD PF11068.8 EMC77932.1 - 3.1 8.2 11.3 5.2 7.4 11.3 1.3 1 0 0 1 1 1 0 YlqD protein WD40 PF00400.32 EMC77933.1 - 6.7e-15 55.2 2.2 0.00033 21.4 0.0 6.4 5 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC77933.1 - 1.2e-05 25.5 0.0 0.011 16.0 0.0 3.6 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain SPRY PF00622.28 EMC77934.1 - 8.3e-19 67.9 0.0 1.1e-18 67.5 0.0 1.2 1 0 0 1 1 1 1 SPRY domain LRR_8 PF13855.6 EMC77935.1 - 4.4e-50 167.3 63.1 1.7e-10 40.5 3.4 10.0 4 4 6 10 10 10 10 Leucine rich repeat LRR_4 PF12799.7 EMC77935.1 - 8.6e-38 127.7 50.3 4e-05 23.9 0.2 11.3 11 0 0 11 11 11 10 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC77935.1 - 3.4e-16 57.3 54.6 1.2 10.0 0.7 18.1 19 1 0 19 19 19 6 Leucine Rich Repeat LRR_9 PF14580.6 EMC77935.1 - 5.7e-05 22.7 17.7 0.01 15.4 0.4 5.0 1 1 3 5 5 5 3 Leucine-rich repeat LRR_5 PF13306.6 EMC77935.1 - 0.00034 20.6 0.0 0.5 10.3 0.2 4.3 4 1 2 6 6 6 2 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 EMC77935.1 - 0.0057 16.6 59.0 7.3 6.9 0.5 16.1 17 0 0 17 17 17 3 Leucine Rich repeat CEP19 PF14933.6 EMC77936.1 - 6.2e-37 127.4 2.2 6.9e-37 127.3 2.2 1.0 1 0 0 1 1 1 1 CEP19-like protein DUF2388 PF09498.10 EMC77936.1 - 0.15 12.1 0.2 0.3 11.1 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2388) PIG-X PF08320.12 EMC77937.1 - 6.8e-40 137.2 0.0 7.8e-40 137.0 0.0 1.0 1 0 0 1 1 1 1 PIG-X / PBN1 Pkinase PF00069.25 EMC77938.1 - 6.2e-74 248.7 0.0 8.3e-74 248.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC77938.1 - 1.7e-47 161.9 0.0 2.6e-47 161.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EMC77938.1 - 3.9e-25 88.0 0.0 9e-25 86.8 0.0 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 EMC77938.1 - 3.5e-08 33.1 0.1 0.00036 20.0 0.0 2.4 1 1 1 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EMC77938.1 - 3.8e-06 25.9 0.0 7e-06 25.1 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMC77938.1 - 0.0035 17.3 0.0 0.046 13.6 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EMC77938.1 - 0.0078 15.2 0.9 0.045 12.7 0.9 1.9 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EMC77938.1 - 0.03 13.7 0.0 0.05 12.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Gal-3-0_sulfotr PF06990.11 EMC77940.1 - 6.4e-125 417.2 0.7 7.2e-125 417.0 0.7 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 EMC77940.1 - 1.3e-05 25.3 0.0 0.00016 21.7 0.0 2.4 1 1 0 1 1 1 1 Sulfotransferase family Transferrin PF00405.17 EMC77941.1 - 1.5e-208 691.6 12.8 1.7e-110 369.3 0.1 3.0 3 0 0 3 3 3 3 Transferrin Phosphonate-bd PF12974.7 EMC77941.1 - 2.3e-05 24.1 0.0 0.031 13.9 0.0 2.7 2 1 0 2 2 2 2 ABC transporter, phosphonate, periplasmic substrate-binding protein DUF3584 PF12128.8 EMC77941.1 - 0.15 9.6 0.0 0.21 9.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) SRPRB PF09439.10 EMC77942.1 - 1.5e-68 229.8 0.1 1.8e-68 229.6 0.1 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 EMC77942.1 - 6e-17 61.6 0.0 8e-17 61.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC77942.1 - 1.1e-08 35.2 0.0 1.6e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC77942.1 - 1.2e-08 34.7 0.3 1.7e-06 27.7 0.3 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Roc PF08477.13 EMC77942.1 - 5.7e-06 26.5 0.0 9.2e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMC77942.1 - 1.1e-05 25.1 0.1 9.8e-05 22.0 0.1 1.9 2 0 0 2 2 2 1 Ras family FeoB_N PF02421.18 EMC77942.1 - 1.2e-05 24.9 0.2 2.5e-05 23.9 0.2 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B G-alpha PF00503.20 EMC77942.1 - 0.0071 15.6 0.2 0.033 13.4 0.1 1.9 1 1 1 2 2 2 1 G-protein alpha subunit Dynamin_N PF00350.23 EMC77942.1 - 0.06 13.4 0.4 0.21 11.6 0.5 1.8 1 1 0 1 1 1 0 Dynamin family OATP PF03137.20 EMC77944.1 - 4e-173 576.6 16.5 4.6e-173 576.4 16.5 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 EMC77944.1 - 1.3e-21 77.0 27.7 1.3e-21 77.0 27.7 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Kazal_2 PF07648.15 EMC77944.1 - 1.3e-08 34.8 6.3 3.5e-08 33.5 6.3 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Sugar_tr PF00083.24 EMC77944.1 - 2.1e-05 23.6 9.7 0.00047 19.1 3.2 2.4 2 1 0 2 2 2 2 Sugar (and other) transporter Kazal_1 PF00050.21 EMC77944.1 - 0.0033 17.4 2.2 0.0089 16.0 2.2 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Angiomotin_C PF12240.8 EMC77945.1 - 1.2e-89 299.3 8.3 1.2e-89 299.3 8.3 3.4 2 1 1 3 3 3 1 Angiomotin C terminal DUF4288 PF14119.6 EMC77945.1 - 7.5 7.0 6.6 1.5 9.2 0.1 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4288) Peptidase_C48 PF02902.19 EMC77946.1 - 1.9e-45 155.3 1.6 1.9e-45 155.3 1.6 1.7 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_C57 PF03290.13 EMC77946.1 - 0.021 13.5 0.1 2.3 6.9 0.0 2.2 1 1 0 2 2 2 0 Vaccinia virus I7 processing peptidase KH_1 PF00013.29 EMC77947.1 - 2.6e-57 190.5 12.7 3.9e-16 58.6 0.2 4.4 4 0 0 4 4 4 4 KH domain KH_2 PF07650.17 EMC77947.1 - 1.1e-16 60.4 8.1 0.00045 20.0 0.1 4.8 4 0 0 4 4 4 4 KH domain KH_4 PF13083.6 EMC77947.1 - 5.2e-16 58.3 1.9 0.0014 18.4 0.1 5.1 5 0 0 5 5 5 4 KH domain RRM_1 PF00076.22 EMC77947.1 - 5.3e-08 32.6 0.0 1.1e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_5 PF13184.6 EMC77947.1 - 5.5e-07 29.6 3.9 0.44 10.7 0.1 4.5 4 0 0 4 4 4 3 NusA-like KH domain MOEP19 PF16005.5 EMC77947.1 - 7.8e-06 25.8 0.1 0.089 12.8 0.0 3.9 4 0 0 4 4 4 1 KH-like RNA-binding domain RRM_3 PF08777.11 EMC77947.1 - 0.033 14.2 0.5 0.24 11.4 0.0 2.4 2 0 0 2 2 2 0 RNA binding motif RRM_5 PF13893.6 EMC77947.1 - 0.07 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SLS PF14611.6 EMC77947.1 - 1.3 8.8 4.8 17 5.2 0.2 3.7 4 1 1 5 5 5 0 Mitochondrial inner-membrane-bound regulator RRM_1 PF00076.22 EMC77948.1 - 2e-22 78.8 0.0 2.6e-22 78.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMC77948.1 - 0.0071 16.2 0.0 0.011 15.6 0.0 1.2 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_3 PF08777.11 EMC77948.1 - 0.01 15.8 0.0 0.016 15.3 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif RSRP PF17069.5 EMC77948.1 - 1.7 8.1 25.9 2.1 7.8 25.9 1.4 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 Spem1 PF15670.5 EMC77948.1 - 1.8 8.1 6.5 1.9 8.0 6.5 1.2 1 0 0 1 1 1 0 Spermatid maturation protein 1 LRR_4 PF12799.7 EMC77949.1 - 1.2e-09 38.3 11.4 1.4e-05 25.4 2.8 3.4 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC77949.1 - 3.8e-07 29.8 0.2 1.2e-06 28.1 0.2 1.8 1 1 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 EMC77949.1 - 1.2e-06 28.1 5.7 7.8e-05 22.4 2.8 3.1 3 1 0 3 3 3 2 Leucine rich repeat Arg_repressor PF01316.21 EMC77949.1 - 0.037 13.8 0.1 0.13 12.1 0.1 2.0 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain Cnd1 PF12717.7 EMC77949.1 - 0.094 12.8 0.2 0.43 10.6 0.2 1.9 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 PFK PF00365.20 EMC77950.1 - 2.5e-196 650.5 5.5 5.9e-101 337.5 0.5 2.0 2 0 0 2 2 2 2 Phosphofructokinase MHC_I_3 PF16497.5 EMC77951.1 - 5.9e-07 29.2 0.0 8.4e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 MHC-I family domain MHC_I PF00129.18 EMC77951.1 - 1.4e-05 24.7 0.0 1.9e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 DnaJ_C PF01556.18 EMC77952.1 - 8.4e-38 129.8 0.1 1.3e-37 129.1 0.1 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EMC77952.1 - 1.3e-28 98.9 0.8 2e-28 98.3 0.8 1.3 1 0 0 1 1 1 1 DnaJ domain Crystall PF00030.19 EMC77953.1 - 8.1e-61 202.2 1.6 1.3e-30 105.4 0.1 2.0 2 0 0 2 2 2 2 Beta/Gamma crystallin IL4_i_Ig PF18258.1 EMC77953.1 - 1.6e-07 31.4 2.8 0.02 15.1 0.5 3.2 2 2 0 2 2 2 2 Interleukin-4 inducing immunoglobulin-binding domain Crystall_3 PF08964.10 EMC77953.1 - 0.0018 18.4 0.3 17 5.7 0.0 3.2 3 0 0 3 3 3 3 Beta/Gamma crystallin Inhibitor_I36 PF03995.13 EMC77953.1 - 0.0059 16.5 3.2 1.7 8.6 0.2 3.6 2 2 2 4 4 4 3 Peptidase inhibitor family I36 LPD18 PF18832.1 EMC77953.1 - 0.031 14.3 0.0 9.4 6.4 0.0 2.2 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 18 PMP22_Claudin PF00822.20 EMC77954.1 - 4.7e-30 104.6 14.3 6.2e-30 104.3 14.3 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC77954.1 - 2.3e-12 47.0 15.4 5.6e-11 42.5 15.4 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Trp_oprn_chp PF09534.10 EMC77954.1 - 0.0025 17.6 1.2 0.052 13.4 1.3 2.3 1 1 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Amastin PF07344.11 EMC77954.1 - 0.51 10.2 11.5 0.36 10.7 9.6 1.7 1 1 0 1 1 1 0 Amastin surface glycoprotein Phage_holin_3_6 PF07332.11 EMC77954.1 - 4.7 7.3 21.3 0.25 11.4 6.2 2.4 1 1 1 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF308 PF03729.13 EMC77954.1 - 5.6 7.4 24.6 0.29 11.5 9.2 3.0 2 1 2 4 4 4 0 Short repeat of unknown function (DUF308) Dzip-like_N PF13815.6 EMC77955.1 - 6e-37 126.2 0.0 6e-37 126.2 0.0 3.1 2 1 0 2 2 2 1 Iguana/Dzip1-like DAZ-interacting protein N-terminal FapA PF03961.13 EMC77955.1 - 0.018 13.7 1.5 0.031 12.9 1.5 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A V_ATPase_I PF01496.19 EMC77955.1 - 0.18 9.7 1.6 0.25 9.2 1.6 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peptidase_S49_N PF08496.10 EMC77955.1 - 0.22 11.6 7.2 0.037 14.1 2.7 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Vfa1 PF08432.10 EMC77955.1 - 0.58 10.5 4.5 0.44 10.8 2.8 1.6 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 EMP24_GP25L PF01105.24 EMC77955.1 - 1.6 8.6 7.9 1.4 8.8 5.3 2.0 1 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Csm1_N PF18504.1 EMC77955.1 - 3 8.2 17.3 7.8 6.9 0.4 2.9 2 1 0 2 2 2 0 Csm1 N-terminal domain YabA PF06156.13 EMC77955.1 - 3.6 8.3 16.2 1.3 9.7 11.8 2.5 2 1 1 3 3 3 0 Initiation control protein YabA ERM PF00769.19 EMC77955.1 - 8.5 6.1 28.7 5.1 6.8 16.7 2.5 2 0 0 2 2 2 0 Ezrin/radixin/moesin family DUF4407 PF14362.6 EMC77955.1 - 8.9 5.6 14.6 19 4.5 14.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Gb3_synth PF04572.12 EMC77956.1 - 1.6e-45 154.4 0.5 2.6e-45 153.8 0.5 1.3 1 0 0 1 1 1 1 Alpha 1,4-glycosyltransferase conserved region Gly_transf_sug PF04488.15 EMC77956.1 - 8.6e-20 71.2 0.0 2.9e-19 69.5 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Pkinase_Tyr PF07714.17 EMC77957.1 - 4.6e-99 330.9 0.0 6.6e-99 330.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.19 EMC77957.1 - 7.4e-72 241.1 0.1 1.3e-71 240.3 0.1 1.4 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.25 EMC77957.1 - 1.8e-49 168.5 0.0 2.9e-49 167.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 EMC77957.1 - 1.9e-31 108.3 3.6 3.5e-15 56.1 0.2 3.8 4 0 0 4 4 4 2 Fibronectin type III domain EphA2_TM PF14575.6 EMC77957.1 - 2e-22 79.9 0.0 4.3e-22 78.8 0.0 1.6 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_1 PF00536.30 EMC77957.1 - 5.8e-20 71.5 0.0 1.4e-19 70.3 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC77957.1 - 5.8e-20 71.2 0.0 9.8e-20 70.4 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ephrin_rec_like PF07699.13 EMC77957.1 - 1.2e-05 24.9 2.8 1.2e-05 24.9 2.8 2.0 2 0 0 2 2 1 1 Putative ephrin-receptor like Pur_ac_phosph_N PF16656.5 EMC77957.1 - 0.00083 19.9 0.3 0.0077 16.8 0.2 2.5 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Haspin_kinase PF12330.8 EMC77957.1 - 0.018 14.0 0.0 0.031 13.2 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain fn3_2 PF16893.5 EMC77957.1 - 0.027 14.6 0.0 1.8 8.8 0.0 2.8 3 0 0 3 3 2 0 Fibronectin type III domain Interfer-bind PF09294.10 EMC77957.1 - 0.055 13.8 0.0 0.42 10.9 0.0 2.4 3 0 0 3 3 2 0 Interferon-alpha/beta receptor, fibronectin type III ABC1 PF03109.16 EMC77957.1 - 0.06 13.5 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 ABC1 family DAP10 PF07213.11 EMC77957.1 - 0.11 12.5 0.0 0.29 11.1 0.0 1.7 1 0 0 1 1 1 0 DAP10 membrane protein VSP PF03302.13 EMC77957.1 - 0.11 11.3 5.4 0.055 12.3 0.9 2.1 2 0 0 2 2 2 0 Giardia variant-specific surface protein cEGF PF12662.7 EMC77957.1 - 0.25 11.3 2.5 0.87 9.6 2.5 1.9 1 0 0 1 1 1 0 Complement Clr-like EGF-like EGF_2 PF07974.13 EMC77957.1 - 3.7 8.0 5.5 0.66 10.4 0.1 2.6 3 0 0 3 3 2 0 EGF-like domain Transglut_core PF01841.19 EMC77958.1 - 0.0058 17.1 0.2 0.033 14.6 0.2 2.2 1 1 0 1 1 1 1 Transglutaminase-like superfamily CEP63 PF17045.5 EMC77959.1 - 8.1e-105 350.6 58.9 8.1e-105 350.6 58.9 5.0 3 1 1 5 5 5 2 Centrosomal protein of 63 kDa Tup_N PF08581.10 EMC77959.1 - 0.014 15.7 10.5 0.014 15.7 10.5 7.7 5 3 1 6 6 6 0 Tup N-terminal Apc13p PF05839.11 EMC77960.1 - 3.6e-20 71.9 0.3 5e-20 71.5 0.3 1.2 1 0 0 1 1 1 1 Apc13p protein Lipase PF00151.19 EMC77961.1 - 5.5e-84 282.3 0.0 7.7e-84 281.9 0.0 1.1 1 0 0 1 1 1 1 Lipase BetaGal_dom2 PF10435.9 EMC77961.1 - 0.038 13.8 0.0 0.079 12.8 0.0 1.5 1 0 0 1 1 1 0 Beta-galactosidase, domain 2 SNARE_assoc PF09335.11 EMC77962.1 - 1e-16 61.5 4.5 1e-16 61.5 4.5 1.5 2 0 0 2 2 2 1 SNARE associated Golgi protein DctQ PF04290.12 EMC77962.1 - 0.029 14.3 1.5 0.21 11.5 1.3 2.0 2 0 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component Pkinase_Tyr PF07714.17 EMC77963.1 - 2.7e-64 216.9 0.0 4.2e-64 216.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC77963.1 - 2.8e-59 200.7 0.0 4.8e-59 199.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EMC77963.1 - 0.001 17.9 0.0 0.0029 16.4 0.0 1.7 1 0 0 1 1 1 1 Fungal protein kinase DUF737 PF05300.11 EMC77963.1 - 0.023 15.1 0.4 0.023 15.1 0.4 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF737) APH PF01636.23 EMC77963.1 - 0.063 13.2 0.0 2 8.3 0.0 3.0 4 0 0 4 4 4 0 Phosphotransferase enzyme family 3HCDH_N PF02737.18 EMC77964.1 - 1.4e-52 178.2 0.2 2.1e-52 177.6 0.2 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.20 EMC77964.1 - 1.5e-34 119.4 0.0 2.5e-34 118.7 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase 3HCDH PF00725.22 EMC77964.1 - 3.3e-31 107.8 0.0 2e-23 82.8 0.0 2.7 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_2 PF16113.5 EMC77964.1 - 2.1e-24 86.7 0.0 4.3e-24 85.6 0.0 1.5 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 EMC77964.1 - 0.0017 18.3 0.0 0.99 9.3 0.0 2.5 2 0 0 2 2 2 2 Peptidase family S49 TrkA_N PF02254.18 EMC77964.1 - 0.014 15.6 0.0 0.034 14.4 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_2 PF03446.15 EMC77964.1 - 0.015 15.5 0.0 0.026 14.7 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EMC77964.1 - 0.088 13.4 0.0 0.21 12.2 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent SeleniumBinding PF11524.8 EMC77964.1 - 0.16 12.4 0.1 0.4 11.1 0.1 1.6 1 0 0 1 1 1 0 Selenium binding protein UPF0524 PF15823.5 EMC77965.1 - 2e-84 282.8 4.3 2.2e-84 282.6 4.3 1.0 1 0 0 1 1 1 1 UPF0524 of C3orf70 NapB PF03892.14 EMC77965.1 - 0.37 10.8 2.7 0.24 11.4 0.8 1.8 1 1 0 1 1 1 0 Nitrate reductase cytochrome c-type subunit (NapB) Vps8 PF12816.7 EMC77966.1 - 3.8e-61 206.1 8.9 3.1e-59 199.8 0.9 3.3 3 0 0 3 3 3 2 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 EMC77966.1 - 2.3e-08 34.0 6.0 2.4e-05 24.2 0.2 3.6 3 0 0 3 3 3 2 Region in Clathrin and VPS zf-RING_11 PF17123.5 EMC77966.1 - 2.3e-05 24.1 5.0 9.1e-05 22.1 5.0 2.1 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EMC77966.1 - 0.0068 16.4 5.8 0.023 14.7 5.8 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EMC77966.1 - 0.013 15.8 8.4 0.043 14.2 8.4 2.0 1 0 0 1 1 1 0 Ring finger domain DUF1828 PF08861.10 EMC77966.1 - 0.13 12.5 0.1 0.74 10.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF1828 PHD PF00628.29 EMC77966.1 - 0.21 11.5 9.0 0.43 10.5 9.0 1.6 1 0 0 1 1 1 0 PHD-finger zf-RING_5 PF14634.6 EMC77966.1 - 3.3 7.8 9.1 11 6.1 9.1 2.0 1 0 0 1 1 1 0 zinc-RING finger domain Thioredoxin PF00085.20 EMC77967.1 - 1.5e-07 31.4 0.0 1.7e-07 31.2 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 EMC77967.1 - 0.11 12.4 0.0 0.17 11.8 0.0 1.4 1 1 0 1 1 1 0 AhpC/TSA family Arm PF00514.23 EMC77968.1 - 4.4e-20 71.0 22.3 0.0002 21.3 0.2 11.2 12 0 0 12 12 12 5 Armadillo/beta-catenin-like repeat HEAT PF02985.22 EMC77968.1 - 1.3e-08 34.4 18.2 0.034 14.4 0.1 8.4 9 0 0 9 9 9 3 HEAT repeat HEAT_EZ PF13513.6 EMC77968.1 - 5.9e-08 33.0 6.4 0.01 16.3 0.1 6.8 8 1 1 9 9 9 2 HEAT-like repeat V-ATPase_H_C PF11698.8 EMC77968.1 - 1.3e-06 28.5 9.7 0.19 11.9 0.0 5.8 4 2 2 6 6 6 3 V-ATPase subunit H Uso1_p115_head PF04869.14 EMC77968.1 - 0.002 17.3 3.2 1.2 8.2 0.1 3.8 3 1 1 4 4 4 1 Uso1 / p115 like vesicle tethering protein, head region ParcG PF10274.9 EMC77968.1 - 0.026 14.6 3.2 0.87 9.7 0.3 3.6 2 1 0 3 3 3 0 Parkin co-regulated protein Cnd1 PF12717.7 EMC77968.1 - 0.093 12.8 16.4 0.56 10.2 0.9 4.6 2 2 2 5 5 5 0 non-SMC mitotic condensation complex subunit 1 RasGEF_N_2 PF14663.6 EMC77968.1 - 1.2 9.5 7.1 12 6.3 0.1 4.5 4 2 1 5 5 5 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain RTTN_N PF14726.6 EMC77968.1 - 7.7 7.4 9.8 63 4.5 0.1 5.0 3 1 1 5 5 5 0 Rotatin, an armadillo repeat protein, centriole functioning DBR1 PF05011.13 EMC77969.1 - 5.8e-37 127.2 0.2 1.1e-36 126.3 0.2 1.5 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain ImpA_N PF06812.12 EMC77969.1 - 0.016 15.3 0.0 0.037 14.1 0.0 1.6 1 0 0 1 1 1 0 ImpA, N-terminal, type VI secretion system Adaptin_binding PF10199.9 EMC77969.1 - 0.044 14.4 4.1 0.38 11.3 4.0 2.4 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 DUF4611 PF15387.6 EMC77969.1 - 9.6 6.5 10.6 0.11 12.8 0.8 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) EF-hand_13 PF17958.1 EMC77970.1 - 6.5e-41 138.1 0.1 1.1e-39 134.1 0.0 2.7 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 EMC77970.1 - 2e-21 76.2 4.4 4e-20 72.0 0.5 3.7 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 EMC77970.1 - 3.7e-06 26.2 0.1 0.00082 18.8 0.0 3.6 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 EMC77970.1 - 0.00017 21.2 1.9 0.037 14.0 0.0 4.3 4 0 0 4 4 4 1 EF-hand domain EF-hand_8 PF13833.6 EMC77970.1 - 0.00031 20.5 0.1 1 9.2 0.0 3.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 EMC77970.1 - 0.00052 19.4 0.9 0.067 12.8 0.1 4.0 4 0 0 4 4 4 1 EF hand SPARC_Ca_bdg PF10591.9 EMC77970.1 - 0.023 15.0 1.4 6 7.2 0.2 2.6 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Carboxyl_trans PF01039.22 EMC77971.1 - 7.4e-190 631.8 0.0 8.6e-190 631.6 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 EMC77971.1 - 0.068 12.6 0.9 0.62 9.5 0.0 2.5 2 1 1 3 3 3 0 Malonate decarboxylase gamma subunit (MdcE) STAG PF08514.11 EMC77972.1 - 2.6e-38 130.4 0.9 1e-37 128.5 0.1 2.4 2 0 0 2 2 2 1 STAG domain Cnd1 PF12717.7 EMC77972.1 - 0.0034 17.4 0.1 0.27 11.3 0.0 3.2 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Cnd3 PF12719.7 EMC77972.1 - 0.0076 15.5 0.3 0.025 13.8 0.3 1.9 1 0 0 1 1 1 1 Nuclear condensing complex subunits, C-term domain Prp18 PF02840.15 EMC77972.1 - 0.024 14.7 3.6 0.17 12.0 0.9 2.8 2 0 0 2 2 2 0 Prp18 domain MinE PF03776.14 EMC77972.1 - 0.14 12.2 4.7 1.6 8.8 0.3 3.1 3 0 0 3 3 3 0 Septum formation topological specificity factor MinE FUSC-like PF12805.7 EMC77972.1 - 2.5 7.1 6.9 1.1 8.3 0.0 3.4 3 1 1 4 4 4 0 FUSC-like inner membrane protein yccS EamA PF00892.20 EMC77973.1 - 5.4e-17 62.2 29.7 1.7e-08 34.7 6.0 2.1 2 0 0 2 2 2 2 EamA-like transporter family Xlink PF00193.17 EMC77974.1 - 1.5e-63 211.2 0.0 3.7e-34 117.0 0.0 2.3 2 0 0 2 2 2 2 Extracellular link domain V-set PF07686.17 EMC77974.1 - 3.3e-10 40.1 0.0 6e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC77974.1 - 3.4e-05 24.3 0.0 0.0001 22.8 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC77974.1 - 3.9e-05 23.6 0.0 8.8e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC77974.1 - 0.00028 21.1 0.0 0.0046 17.3 0.0 2.3 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC77974.1 - 0.0064 16.6 0.1 0.016 15.4 0.1 1.7 1 1 0 1 1 1 1 Immunoglobulin domain Izumo-Ig PF16706.5 EMC77974.1 - 0.049 13.7 0.0 0.15 12.2 0.0 1.8 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Mab-21 PF03281.14 EMC77975.1 - 2.9e-11 43.2 3.7 7.2e-11 41.9 3.9 1.7 1 1 0 1 1 1 1 Mab-21 protein Pes-10 PF07149.11 EMC77975.1 - 7.3 5.5 9.5 9.8 5.1 9.5 1.1 1 0 0 1 1 1 0 Pes-10 F5_F8_type_C PF00754.25 EMC77976.1 - 2.5e-62 208.6 6.4 2.1e-32 111.9 0.9 2.1 2 0 0 2 2 2 2 F5/8 type C domain EGF PF00008.27 EMC77976.1 - 4.9e-13 49.1 20.7 8.6e-08 32.3 7.4 2.7 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.7 EMC77976.1 - 7.5e-05 23.2 25.9 0.00053 20.5 4.3 3.7 3 1 0 3 3 3 2 Human growth factor-like EGF EGF_2 PF07974.13 EMC77976.1 - 0.00092 19.5 22.8 0.07 13.5 7.4 2.8 2 0 0 2 2 2 2 EGF-like domain DUF1438 PF07270.11 EMC77976.1 - 0.03 14.4 0.2 12 6.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1438) Pepdidase_M14_N PF18027.1 EMC77976.1 - 0.16 12.4 3.8 0.68 10.3 0.2 2.7 2 1 1 3 3 3 0 Cytosolic carboxypeptidase N-terminal domain EGF_3 PF12947.7 EMC77976.1 - 1.9 8.8 17.8 1.4 9.2 3.4 2.6 1 1 1 2 2 2 0 EGF domain COX7C PF02935.16 EMC77977.1 - 2.4e-24 85.3 0.2 2.6e-24 85.2 0.2 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc RasGAP PF00616.19 EMC77978.1 - 2.3e-27 96.1 4.8 6.7e-19 68.4 0.1 2.7 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase SH2 PF00017.24 EMC77978.1 - 8.7e-24 83.4 0.1 3.5e-21 75.1 0.0 2.8 2 0 0 2 2 2 2 SH2 domain PH PF00169.29 EMC77978.1 - 3e-18 66.3 0.2 2e-17 63.6 0.1 2.5 2 0 0 2 2 2 1 PH domain C2 PF00168.30 EMC77978.1 - 3.5e-12 46.5 0.1 7.4e-12 45.5 0.1 1.6 1 0 0 1 1 1 1 C2 domain SH3_1 PF00018.28 EMC77978.1 - 3.6e-10 39.3 0.0 7.7e-10 38.2 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC77978.1 - 5.2e-05 23.0 0.0 0.00011 21.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.6 EMC77978.1 - 0.0004 20.8 1.0 0.0071 16.8 0.5 2.8 2 1 0 2 2 2 1 Pleckstrin homology domain Cyclin_C_2 PF16899.5 EMC77979.1 - 1.2e-24 86.7 0.1 7.4e-23 80.9 0.1 2.3 2 0 0 2 2 2 1 Cyclin C-terminal domain Cyclin_N PF00134.23 EMC77979.1 - 1.9e-09 37.4 0.2 4.1e-09 36.2 0.2 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EMC77979.1 - 0.15 12.2 1.8 1 9.5 0.5 2.6 2 2 0 2 2 2 0 Cyclin, C-terminal domain UBA2_C PF16195.5 EMC77979.1 - 0.19 12.5 0.3 0.19 12.5 0.3 1.7 2 0 0 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus TLV_coat PF00429.19 EMC77980.1 - 6e-08 31.8 2.7 7.5e-08 31.5 2.7 1.1 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) GP41 PF00517.17 EMC77980.1 - 0.00073 19.5 1.7 0.004 17.1 1.5 1.9 1 1 0 2 2 2 1 Retroviral envelope protein DUF2207 PF09972.9 EMC77980.1 - 0.024 13.4 0.0 0.029 13.1 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Sulfate_transp PF00916.20 EMC77981.1 - 1.5e-35 122.7 3.0 1.5e-35 122.7 3.0 1.7 2 0 0 2 2 2 1 Sulfate permease family STAS PF01740.21 EMC77981.1 - 2.6e-22 78.6 0.0 1.6e-21 76.1 0.0 2.0 1 1 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EMC77981.1 - 5.2e-06 26.8 2.2 5.2e-06 26.8 2.2 2.1 2 1 1 3 3 3 1 Molybdate transporter of MFS superfamily Pkinase PF00069.25 EMC77982.1 - 3.4e-42 144.7 5.0 2.2e-22 79.7 0.0 2.7 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMC77982.1 - 3e-14 52.9 0.0 2.8e-10 39.9 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase SR-25 PF10500.9 EMC77982.1 - 0.0085 15.7 4.9 0.02 14.5 4.9 1.6 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Pkinase_fungal PF17667.1 EMC77982.1 - 0.47 9.2 6.8 0.047 12.5 0.9 2.2 1 1 2 3 3 3 0 Fungal protein kinase NARP1 PF12569.8 EMC77982.1 - 4.1 6.2 8.4 8.2 5.2 8.4 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 L_HMGIC_fpl PF10242.9 EMC77983.1 - 4.8e-68 229.0 13.6 5.5e-68 228.7 13.6 1.0 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein PMP22_Claudin PF00822.20 EMC77983.1 - 9.2e-07 28.9 9.7 1.4e-06 28.3 9.7 1.3 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Colipase_C PF02740.14 EMC77984.1 - 6.9e-28 96.6 4.4 6.9e-28 96.6 4.4 1.8 2 0 0 2 2 2 1 Colipase, C-terminal domain Colipase PF01114.18 EMC77984.1 - 2.8e-13 49.3 7.0 2.8e-13 49.3 7.0 1.8 2 0 0 2 2 2 1 Colipase, N-terminal domain Prokineticin PF06607.11 EMC77984.1 - 2.7 8.4 8.4 6.9 7.1 8.4 1.7 1 1 0 1 1 1 0 Prokineticin Tub PF01167.18 EMC77987.1 - 7e-95 317.4 0.1 1.4e-94 316.4 0.0 1.5 2 0 0 2 2 2 1 Tub family DUF3527 PF12043.8 EMC77987.1 - 0.27 10.8 2.4 0.72 9.4 0.0 2.7 3 1 0 3 3 3 0 Domain of unknown function (DUF3527) TMEM214 PF10151.9 EMC77987.1 - 5 5.5 6.2 7.3 4.9 6.2 1.1 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator YBD PF17725.1 EMC77988.1 - 6.3e-96 320.2 0.5 8.1e-96 319.8 0.5 1.1 1 0 0 1 1 1 1 YAP binding domain TEA PF01285.18 EMC77988.1 - 4.3e-27 94.0 0.0 8.8e-27 93.0 0.0 1.5 1 0 0 1 1 1 1 TEA/ATTS domain Rotamase_2 PF13145.6 EMC77988.1 - 0.13 13.1 0.0 0.26 12.1 0.0 1.4 1 0 0 1 1 1 0 PPIC-type PPIASE domain Exo_endo_phos PF03372.23 EMC77989.1 - 1.4e-16 60.8 0.0 2.3e-16 60.0 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF3585 PF12130.8 EMC77990.1 - 2.4e-35 121.6 17.4 3.4e-35 121.1 17.4 1.2 1 0 0 1 1 1 1 Bivalent Mical/EHBP Rab binding domain DUF4778 PF16008.5 EMC77990.1 - 0.015 15.4 1.3 0.018 15.1 0.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4778) MRVI1 PF05781.12 EMC77991.1 - 1e-51 176.3 9.6 8.8e-49 166.6 6.6 2.2 2 0 0 2 2 2 2 MRVI1 protein UBN_AB PF14075.6 EMC77991.1 - 0.023 14.4 0.1 0.039 13.7 0.1 1.4 1 1 0 1 1 1 0 Ubinuclein conserved middle domain FapA PF03961.13 EMC77991.1 - 0.34 9.5 0.7 0.46 9.0 0.7 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A FA_FANCE PF11510.8 EMC77992.1 - 2.4e-59 200.9 10.8 2.6e-59 200.7 10.8 1.0 1 0 0 1 1 1 1 Fanconi Anaemia group E protein FANCE zf-C3HC4 PF00097.25 EMC77993.1 - 2.6e-06 27.2 0.9 6.3e-06 26.0 0.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf_CCCH_4 PF18345.1 EMC77993.1 - 4.3e-05 23.4 1.0 4.3e-05 23.4 1.0 2.7 2 1 0 2 2 1 1 Zinc finger domain zf-RING_2 PF13639.6 EMC77993.1 - 8.6e-05 22.8 2.0 8.6e-05 22.8 2.0 2.1 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 EMC77993.1 - 0.00035 20.8 0.7 0.00035 20.8 0.7 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EMC77993.1 - 0.00036 20.6 2.4 0.00083 19.5 2.4 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-CCCH PF00642.24 EMC77993.1 - 0.0012 18.8 2.4 0.0028 17.5 2.4 1.8 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EMC77993.1 - 0.0015 18.3 3.9 0.0047 16.7 3.9 1.9 1 0 0 1 1 1 1 CCCH-type zinc finger zf-RING_5 PF14634.6 EMC77993.1 - 0.0016 18.4 0.7 0.0016 18.4 0.7 1.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EMC77993.1 - 0.011 15.7 0.9 0.011 15.7 0.9 2.3 4 0 0 4 4 4 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 EMC77993.1 - 0.019 15.0 1.1 0.023 14.7 0.2 1.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Torus PF16131.5 EMC77993.1 - 0.034 14.8 2.2 0.055 14.2 2.2 1.6 1 1 0 1 1 1 0 Torus domain zf-C3HC4_2 PF13923.6 EMC77993.1 - 1 9.2 8.6 1.4 8.8 5.9 2.5 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC77993.1 - 6.8 6.6 9.3 0.46 10.4 3.5 1.9 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C4 PF00105.18 EMC77994.1 - 3.2e-28 98.0 17.6 6.1e-28 97.1 17.6 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 EMC77994.1 - 3.7e-15 56.1 0.0 9.1e-15 54.8 0.0 1.6 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor TFIIE-A_C PF11521.8 EMC77994.1 - 0.53 10.6 7.2 5.2 7.5 0.1 2.5 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha zf-H2C2_2 PF13465.6 EMC77995.1 - 2.7e-38 128.7 42.4 3.7e-09 36.6 1.0 6.6 6 0 0 6 6 6 6 Zinc-finger double domain zf-C2H2 PF00096.26 EMC77995.1 - 4.4e-26 89.8 36.2 1.4e-06 28.4 0.3 6.6 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC77995.1 - 2.8e-16 58.8 39.1 0.0013 19.4 0.3 6.9 7 0 0 7 7 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC77995.1 - 9.9e-08 32.1 3.5 0.09 13.1 0.1 5.4 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 EMC77995.1 - 2.5e-05 24.5 15.0 0.0096 16.2 5.0 3.1 1 1 2 3 3 3 2 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.5 EMC77995.1 - 0.0013 18.9 15.8 1.7 8.8 0.4 4.7 1 1 2 4 4 4 3 Aberrant zinc-finger zf-TRAF PF02176.18 EMC77995.1 - 0.0016 19.1 0.7 0.0016 19.1 0.7 3.1 2 2 1 3 3 3 1 TRAF-type zinc finger CopK PF11525.8 EMC77995.1 - 0.023 14.3 0.1 17 5.2 0.0 3.2 1 1 1 3 3 3 0 Copper resistance protein K Chorion_2 PF03964.15 EMC77995.1 - 0.35 11.7 3.4 0.62 10.9 1.8 2.3 2 0 0 2 2 2 0 Chorion family 2 zf-met PF12874.7 EMC77995.1 - 0.64 10.5 13.6 2.8 8.4 0.1 4.8 5 0 0 5 5 5 0 Zinc-finger of C2H2 type CCAP PF11105.8 EMC77995.1 - 2.3 8.2 5.7 11 6.0 0.8 2.8 1 1 1 2 2 2 0 Arthropod cardioacceleratory peptide 2a FOXP-CC PF16159.5 EMC77995.1 - 2.7 8.7 12.7 1 10.0 0.6 5.0 5 1 1 6 6 6 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 EMC77995.1 - 5.2 7.2 31.1 2.2 8.4 1.8 6.2 7 0 0 7 7 7 0 C2H2-type zinc finger Ribosomal_L1 PF00687.21 EMC77996.1 - 1.1e-35 123.3 2.3 1.2e-35 123.1 2.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF3671 PF12420.8 EMC77996.1 - 0.035 14.2 2.5 0.055 13.6 2.5 1.4 1 1 0 1 1 1 0 Protein of unknown function TetR PF13972.6 EMC77996.1 - 0.1 12.3 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial transcriptional repressor Amelotin PF15757.5 EMC77997.1 - 1.3e-06 28.1 27.5 1.5 8.3 0.5 6.3 1 1 5 6 6 6 6 Amelotin Fibrinogen_BP PF08017.11 EMC77997.1 - 0.73 8.2 33.5 0.98 7.8 33.5 1.1 1 0 0 1 1 1 0 Fibrinogen binding protein Cornifin PF02389.15 EMC77997.1 - 3.2 8.0 42.4 12 6.1 12.4 3.5 1 1 2 3 3 3 0 Cornifin (SPRR) family FXa_inhibition PF14670.6 EMC77998.1 - 5.7e-58 192.9 183.1 6.6e-11 42.3 8.1 12.6 12 2 0 12 12 12 9 Coagulation Factor Xa inhibitory site Ephrin_rec_like PF07699.13 EMC77998.1 - 5e-38 128.6 44.4 1.4e-14 53.5 6.8 6.7 5 1 1 6 6 6 3 Putative ephrin-receptor like cEGF PF12662.7 EMC77998.1 - 5.8e-37 125.2 103.1 2.4e-08 33.8 0.8 12.2 13 1 0 13 13 13 8 Complement Clr-like EGF-like EGF_CA PF07645.15 EMC77998.1 - 9.9e-30 102.5 167.0 5.5e-09 36.1 10.1 11.8 12 0 0 12 12 12 6 Calcium-binding EGF domain CUB PF00431.20 EMC77998.1 - 1.5e-18 67.2 0.0 4.3e-18 65.7 0.0 1.9 1 0 0 1 1 1 1 CUB domain EGF_3 PF12947.7 EMC77998.1 - 9.2e-18 64.1 154.0 3.5e-10 39.9 11.7 12.1 12 0 0 12 12 12 8 EGF domain EGF PF00008.27 EMC77998.1 - 6.7e-16 58.3 135.9 1.6e-05 25.1 7.2 12.0 11 0 0 11 11 11 8 EGF-like domain hEGF PF12661.7 EMC77998.1 - 0.00099 19.7 1.4 0.00099 19.7 1.4 12.9 12 0 0 12 12 12 5 Human growth factor-like EGF V-ATPase_G PF03179.15 EMC77998.1 - 0.44 11.1 1.9 1 9.9 1.9 1.5 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit Ank_2 PF12796.7 EMC77999.1 - 7.2e-40 135.5 8.0 1.1e-17 64.4 0.5 4.1 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC77999.1 - 2.6e-37 126.4 16.0 1e-10 41.6 0.0 6.4 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC77999.1 - 1.8e-35 120.8 6.3 2.8e-08 34.1 0.1 5.2 3 1 1 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 EMC77999.1 - 9.8e-35 117.5 15.9 2.7e-05 24.4 0.3 6.9 6 0 0 6 6 6 6 Ankyrin repeat Ank_3 PF13606.6 EMC77999.1 - 1.1e-33 111.4 4.1 7.1e-05 22.9 0.0 6.8 6 0 0 6 6 6 6 Ankyrin repeat SAM_1 PF00536.30 EMC77999.1 - 3.7e-22 78.5 0.0 3.2e-12 46.7 0.0 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC77999.1 - 3.7e-20 71.8 0.2 9.1e-13 48.1 0.1 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) PID PF00640.23 EMC77999.1 - 1.9e-18 66.8 0.4 4.8e-18 65.5 0.4 1.7 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 EMC77999.1 - 0.0039 17.3 0.0 0.0077 16.4 0.0 1.5 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID_2 PF14719.6 EMC77999.1 - 0.046 13.6 0.0 0.079 12.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) Chorein_N PF12624.7 EMC78000.1 - 1.5e-15 57.3 0.1 6.7e-14 52.0 0.0 2.8 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 zf-U1 PF06220.12 EMC78001.1 - 1.9e-20 72.3 8.3 2.5e-20 71.9 8.3 1.2 1 0 0 1 1 1 1 U1 zinc finger Phage_int_SAM_3 PF14659.6 EMC78001.1 - 0.12 12.6 0.1 0.7 10.2 0.1 1.9 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain zf-C2H2_jaz PF12171.8 EMC78001.1 - 2.1 8.7 9.9 25 5.3 9.9 2.1 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC78001.1 - 2.5 8.6 5.1 24 5.5 5.1 2.1 1 1 0 1 1 1 0 Zinc-finger of C2H2 type N_BRCA1_IG PF16158.5 EMC78002.1 - 4.6e-34 117.2 0.2 8.3e-34 116.4 0.2 1.4 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene CARDB PF07705.11 EMC78002.1 - 0.067 13.5 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 CARDB Ets PF00178.22 EMC78003.1 - 1.6e-34 118.2 1.0 3.8e-34 117.0 1.0 1.6 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.16 EMC78003.1 - 7.9e-19 67.4 0.2 1.6e-18 66.4 0.2 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain FCH PF00611.23 EMC78004.1 - 1.9e-16 60.1 0.2 1.9e-16 60.1 0.2 2.9 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.6 EMC78004.1 - 3e-15 55.8 0.4 6.4e-15 54.7 0.4 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC78004.1 - 1e-14 53.9 0.1 2.1e-14 52.8 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC78004.1 - 1.8e-07 30.7 0.0 4.3e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain KAP_NTPase PF07693.14 EMC78004.1 - 0.042 13.1 1.1 0.06 12.6 1.1 1.2 1 0 0 1 1 1 0 KAP family P-loop domain DUF3450 PF11932.8 EMC78004.1 - 0.25 10.6 10.7 0.63 9.3 10.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) PilJ PF13675.6 EMC78004.1 - 0.29 11.2 4.1 0.38 10.8 0.1 2.6 2 1 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term PAP_central PF04928.17 EMC78004.1 - 0.38 9.7 3.9 0.79 8.6 3.9 1.5 1 0 0 1 1 1 0 Poly(A) polymerase central domain Tho2 PF11262.8 EMC78004.1 - 2 7.5 15.8 1 8.5 11.1 2.3 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 LOH1CR12 PF10158.9 EMC78004.1 - 3.9 7.5 9.2 2.2 8.3 6.0 2.2 1 1 0 2 2 2 0 Tumour suppressor protein OmpH PF03938.14 EMC78004.1 - 7 7.0 24.8 0.18 12.1 16.3 2.4 2 1 1 3 3 3 0 Outer membrane protein (OmpH-like) TPR_MLP1_2 PF07926.12 EMC78004.1 - 7.2 6.7 24.9 25 4.9 0.2 3.2 1 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein S10_plectin PF03501.15 EMC78005.1 - 2e-49 165.6 0.2 2.5e-49 165.3 0.2 1.1 1 0 0 1 1 1 1 Plectin/S10 domain 7tm_1 PF00001.21 EMC78007.1 - 2.5e-46 158.2 12.2 3.5e-46 157.7 12.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Rhodopsin_N PF10413.9 EMC78007.1 - 1.1e-25 89.2 3.3 2.5e-25 88.0 3.3 1.7 1 0 0 1 1 1 1 Amino terminal of the G-protein receptor rhodopsin 7TM_GPCR_Srw PF10324.9 EMC78007.1 - 9.1e-14 51.5 16.1 6.5e-13 48.6 16.1 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.9 EMC78007.1 - 1.2e-07 31.4 15.4 1.8e-07 30.8 15.4 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 EMC78007.1 - 2e-07 30.7 16.1 2.8e-07 30.2 16.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv TAS2R PF05296.13 EMC78007.1 - 7.8e-05 21.9 8.6 0.00099 18.3 1.5 2.2 2 0 0 2 2 2 2 Taste receptor protein (TAS2R) 7tm_4 PF13853.6 EMC78007.1 - 0.00016 21.5 12.2 0.00075 19.3 12.2 1.9 1 1 0 1 1 1 1 Olfactory receptor DUF4079 PF13301.6 EMC78007.1 - 0.0021 18.2 4.4 0.051 13.7 0.6 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF4079) FA_desaturase PF00487.24 EMC78007.1 - 1.4 8.6 12.5 0.14 11.9 0.4 2.3 2 1 0 2 2 2 0 Fatty acid desaturase 60KD_IMP PF02096.20 EMC78007.1 - 2.1 8.2 7.7 15 5.4 7.7 2.4 1 1 0 1 1 1 0 60Kd inner membrane protein MSC PF09402.10 EMC78008.1 - 6.1e-20 71.9 0.1 8.2e-20 71.5 0.1 1.2 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain PV-1 PF06637.11 EMC78008.1 - 0.0041 16.0 0.0 0.0064 15.4 0.0 1.3 1 0 0 1 1 1 1 PV-1 protein (PLVAP) DUF4094 PF13334.6 EMC78008.1 - 0.05 14.0 0.1 0.15 12.5 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) DHHC PF01529.20 EMC78008.1 - 0.078 13.1 0.5 4.2 7.5 0.1 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase Post_transc_reg PF13797.6 EMC78008.1 - 0.093 12.6 1.5 0.16 11.8 0.4 1.9 2 0 0 2 2 2 0 Post-transcriptional regulator IPK PF03770.16 EMC78009.1 - 6.3e-24 84.9 0.3 8.9e-24 84.4 0.3 1.2 1 0 0 1 1 1 1 Inositol polyphosphate kinase RelB_transactiv PF16181.5 EMC78010.1 - 0.031 14.5 1.2 0.04 14.2 1.2 1.2 1 0 0 1 1 1 0 RelB transactivation domain TspO_MBR PF03073.15 EMC78012.1 - 2.4e-40 137.7 5.3 2.8e-40 137.5 5.3 1.0 1 0 0 1 1 1 1 TspO/MBR family APOBEC2 PF18772.1 EMC78013.1 - 7.2e-59 198.8 2.4 8.5e-59 198.5 2.4 1.1 1 0 0 1 1 1 1 APOBEC2 NAD1 PF18778.1 EMC78013.1 - 9.5e-59 198.4 2.0 1.1e-58 198.2 2.0 1.1 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 APOBEC_N PF08210.11 EMC78013.1 - 3e-52 177.1 2.6 3.8e-52 176.8 2.6 1.1 1 0 0 1 1 1 1 APOBEC-like N-terminal domain NAD2 PF18782.1 EMC78013.1 - 6.6e-45 153.4 2.7 7.7e-45 153.2 2.7 1.0 1 0 0 1 1 1 1 Novel AID APOBEC clade 2 SNAD4 PF18750.1 EMC78013.1 - 3e-34 117.6 0.4 4e-34 117.1 0.4 1.2 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC3 PF18771.1 EMC78013.1 - 4.6e-26 91.6 0.2 6.6e-26 91.1 0.2 1.1 1 0 0 1 1 1 1 APOBEC3 APOBEC_C PF05240.14 EMC78013.1 - 6.4e-26 90.1 0.5 9.5e-26 89.6 0.5 1.3 1 0 0 1 1 1 1 APOBEC-like C-terminal domain APOBEC4_like PF18774.1 EMC78013.1 - 9.8e-22 77.3 0.5 1.3e-21 76.9 0.5 1.1 1 0 0 1 1 1 1 APOBEC4-like -AID/APOBEC-deaminase APOBEC4 PF18775.1 EMC78013.1 - 1.4e-17 63.6 0.1 1.9e-17 63.2 0.1 1.2 1 0 0 1 1 1 1 APOBEC4 APOBEC1 PF18769.1 EMC78013.1 - 2e-14 53.6 0.0 3.2e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 APOBEC1 dCMP_cyt_deam_1 PF00383.23 EMC78013.1 - 7.6e-05 22.5 0.0 0.00014 21.7 0.0 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EMC78013.1 - 0.00058 19.6 0.0 0.00082 19.1 0.0 1.3 1 0 0 1 1 1 1 MafB19-like deaminase PfaD_N PF18328.1 EMC78013.1 - 0.16 11.9 0.1 0.95 9.5 0.0 2.3 4 0 0 4 4 4 0 Fatty acid synthase subunit PfaD N-terminal domain Macro PF01661.21 EMC78014.1 - 2.2e-08 34.2 0.0 3.5e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Macro domain Il2rg PF15874.5 EMC78014.1 - 0.051 13.8 0.0 0.069 13.4 0.0 1.2 1 0 0 1 1 1 0 Putative Interleukin 2 receptor, gamma chain PSII_Pbs27 PF13326.6 EMC78014.1 - 0.11 12.8 0.0 0.35 11.2 0.0 1.6 1 1 0 2 2 2 0 Photosystem II Pbs27 Keratin PF02422.16 EMC78015.1 - 6.4e-33 112.3 15.1 7.8e-33 112.1 15.1 1.1 1 0 0 1 1 1 1 Keratin DUF3432 PF11914.8 EMC78015.1 - 0.21 11.8 9.7 0.5 10.6 9.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3432) 7tm_4 PF13853.6 EMC78016.1 - 5.9e-52 177.1 16.7 7.1e-52 176.9 16.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC78016.1 - 1.7e-29 102.9 16.1 2.4e-29 102.5 16.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Stathmin PF00836.19 EMC78017.1 - 7.3e-57 191.1 24.8 1e-56 190.6 24.8 1.2 1 0 0 1 1 1 1 Stathmin family CCDC84 PF14968.6 EMC78017.1 - 0.017 14.8 2.7 0.015 14.9 2.7 1.1 1 0 0 1 1 1 0 Coiled coil protein 84 FmdE PF02663.14 EMC78017.1 - 0.31 11.1 5.9 1.7 8.7 6.0 2.0 1 1 0 1 1 1 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon Exonuc_VII_L PF02601.15 EMC78017.1 - 0.54 9.8 7.6 0.56 9.7 7.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Type2_restr_D3 PF16902.5 EMC78017.1 - 1.6 8.7 4.9 10 6.1 0.2 2.5 1 1 0 2 2 2 0 Type-2 restriction enzyme D3 domain HLH PF00010.26 EMC78018.1 - 3.5e-17 62.1 1.1 5.6e-17 61.5 1.1 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 EMC78018.1 - 1e-11 44.9 0.0 1.7e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Hairy Orange dCache_2 PF08269.11 EMC78018.1 - 0.047 12.9 0.0 0.069 12.3 0.0 1.1 1 0 0 1 1 1 0 Cache domain MRP-S35 PF10246.9 EMC78019.1 - 3.9e-54 181.1 0.1 4.5e-54 180.9 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein MRP-S35 S1 PF00575.23 EMC78019.1 - 0.0065 16.8 0.0 0.0092 16.3 0.0 1.2 1 0 0 1 1 1 1 S1 RNA binding domain TPD52 PF04201.15 EMC78020.1 - 5.5e-74 247.2 8.7 6.6e-74 246.9 8.7 1.1 1 0 0 1 1 1 1 Tumour protein D52 family PEP-utilisers_N PF05524.13 EMC78020.1 - 0.0034 17.5 2.2 0.006 16.7 2.2 1.4 1 0 0 1 1 1 1 PEP-utilising enzyme, N-terminal Cob_adeno_trans PF01923.18 EMC78020.1 - 0.0056 16.8 0.9 0.0078 16.4 0.9 1.3 1 0 0 1 1 1 1 Cobalamin adenosyltransferase Occludin_ELL PF07303.13 EMC78020.1 - 0.012 16.3 2.7 0.94 10.2 0.2 2.4 1 1 1 2 2 2 0 Occludin homology domain Ada3 PF10198.9 EMC78020.1 - 0.015 15.5 0.8 0.022 14.9 0.8 1.3 1 0 0 1 1 1 0 Histone acetyltransferases subunit 3 Uds1 PF15456.6 EMC78020.1 - 0.019 15.2 9.2 0.033 14.4 9.0 1.5 1 1 0 1 1 1 0 Up-regulated During Septation WXG100 PF06013.12 EMC78020.1 - 0.033 14.4 7.1 0.75 10.1 0.4 2.9 3 0 0 3 3 3 0 Proteins of 100 residues with WXG HsbA PF12296.8 EMC78020.1 - 0.056 13.9 6.1 0.34 11.4 1.0 2.4 1 1 1 2 2 2 0 Hydrophobic surface binding protein A RNA_pol_A_CTD PF03118.15 EMC78020.1 - 0.077 12.8 1.9 0.18 11.6 1.3 1.9 2 0 0 2 2 2 0 Bacterial RNA polymerase, alpha chain C terminal domain Atg14 PF10186.9 EMC78020.1 - 0.082 12.0 3.9 0.11 11.6 3.9 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CHGN PF05679.16 EMC78020.1 - 0.087 11.6 1.2 0.1 11.4 1.2 1.1 1 0 0 1 1 1 0 Chondroitin N-acetylgalactosaminyltransferase IBN_N PF03810.19 EMC78020.1 - 0.11 12.4 1.3 0.4 10.6 1.1 2.0 1 1 1 2 2 2 0 Importin-beta N-terminal domain Cnn_1N PF07989.11 EMC78020.1 - 0.21 11.8 9.2 0.083 13.1 4.5 2.5 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 APG6_N PF17675.1 EMC78020.1 - 0.26 11.8 8.2 0.11 13.0 5.8 1.7 2 0 0 2 2 2 0 Apg6 coiled-coil region TBCC_N PF16752.5 EMC78020.1 - 0.26 11.7 6.5 0.078 13.4 2.8 1.9 1 1 1 2 2 2 0 Tubulin-specific chaperone C N-terminal domain Wx5_PLAF3D7 PF09688.10 EMC78020.1 - 0.28 11.2 5.7 0.2 11.7 4.2 1.5 2 0 0 2 2 1 0 Protein of unknown function (Wx5_PLAF3D7) OmpH PF03938.14 EMC78020.1 - 0.43 10.9 9.5 0.79 10.1 8.9 1.7 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) FlaC_arch PF05377.11 EMC78020.1 - 1.1 9.6 4.4 10 6.6 0.9 3.1 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) SlyX PF04102.12 EMC78020.1 - 1.2 9.8 6.6 9.7 6.9 5.9 2.4 1 1 1 2 2 2 0 SlyX DUF1192 PF06698.11 EMC78020.1 - 1.3 9.1 6.4 2.9 8.0 4.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1192) TMPIT PF07851.13 EMC78020.1 - 1.3 8.2 6.6 1.8 7.7 6.6 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF3762 PF12591.8 EMC78021.1 - 0.00013 22.1 0.0 0.00021 21.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3762) T4SS-DNA_transf PF02534.14 EMC78021.1 - 0.1 11.4 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer zf-C2H2 PF00096.26 EMC78022.1 - 0.016 15.6 1.7 0.026 15.0 0.1 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type COMPASS-Shg1 PF05205.12 EMC78023.1 - 6.7e-14 52.4 0.0 8.2e-14 52.1 0.0 1.1 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 RRM_7 PF16367.5 EMC78024.1 - 3.1e-37 126.6 0.0 4.2e-36 123.0 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif CEBP_ZZ PF16366.5 EMC78024.1 - 1.6e-20 73.1 5.1 4.2e-20 71.7 5.1 1.8 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.22 EMC78024.1 - 2e-10 40.4 0.0 2.4e-07 30.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-U1 PF06220.12 EMC78024.1 - 0.029 14.1 0.4 0.078 12.8 0.4 1.7 1 0 0 1 1 1 0 U1 zinc finger Calcyon PF06387.11 EMC78025.1 - 1.5e-88 295.5 0.1 1.7e-88 295.4 0.1 1.0 1 0 0 1 1 1 1 D1 dopamine receptor-interacting protein (calcyon) NB PF04159.13 EMC78025.1 - 0.16 12.0 0.0 0.22 11.6 0.0 1.2 1 0 0 1 1 1 0 NB glycoprotein Homeodomain PF00046.29 EMC78026.1 - 1.1e-16 60.4 3.2 1.5e-16 59.9 3.2 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC78026.1 - 0.04 13.8 0.3 0.072 13.0 0.3 1.5 1 0 0 1 1 1 0 Homeobox KN domain Homez PF11569.8 EMC78026.1 - 0.092 12.2 0.5 0.48 9.9 0.1 2.0 1 1 1 2 2 2 0 Homeodomain leucine-zipper encoding, Homez 7tm_1 PF00001.21 EMC78027.1 - 1.8e-71 240.6 20.0 2.2e-71 240.3 20.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC78027.1 - 4e-09 36.2 18.4 7e-09 35.4 18.4 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC78027.1 - 1.2e-07 31.6 15.7 1.2e-07 31.6 15.7 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF621 PF04789.15 EMC78027.1 - 0.12 11.5 18.8 0.04 13.1 14.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF621) Mtc PF03820.17 EMC78028.1 - 5e-153 508.7 0.3 5.7e-153 508.5 0.3 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier Kinesin PF00225.23 EMC78029.1 - 1.1e-102 343.4 0.1 1.1e-102 343.4 0.1 1.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EMC78029.1 - 5.4e-18 65.3 0.5 3.3e-15 56.3 0.0 3.1 3 0 0 3 3 3 2 Microtubule binding HSP70 PF00012.20 EMC78029.1 - 0.064 11.4 10.0 0.12 10.6 10.0 1.4 1 0 0 1 1 1 0 Hsp70 protein Phage_GPO PF05929.11 EMC78029.1 - 9.4 5.8 16.6 12 5.5 11.2 3.0 2 1 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase Bromodomain PF00439.25 EMC78030.1 - 1.9e-41 140.0 0.4 1.6e-20 72.9 0.1 2.7 2 0 0 2 2 2 2 Bromodomain HMW1C_N PF18071.1 EMC78030.1 - 1.9e-05 24.5 0.7 0.13 12.1 0.1 2.6 2 0 0 2 2 2 2 HMW1C N-terminal TSC22 PF01166.18 EMC78030.1 - 0.22 11.9 2.3 0.61 10.4 2.3 1.8 1 0 0 1 1 1 0 TSC-22/dip/bun family DUF2209 PF09974.9 EMC78030.1 - 0.24 11.7 3.3 1 9.7 3.3 2.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Ribosomal_L7Ae PF01248.26 EMC78031.1 - 1.5e-23 82.3 0.1 1.7e-23 82.1 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ribosomal_L31e PF01198.19 EMC78031.1 - 0.064 13.5 0.9 0.09 13.0 0.9 1.2 1 0 0 1 1 1 0 Ribosomal protein L31e Glyco_transf_7C PF02709.14 EMC78032.1 - 3.1e-27 94.0 0.1 5e-27 93.4 0.1 1.3 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Lectin_leg-like PF03388.13 EMC78033.1 - 1.5e-91 305.9 0.0 1.8e-91 305.6 0.0 1.0 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 EMC78033.1 - 1.7e-07 31.5 0.0 2.4e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 Bacterial lectin UL42 PF17638.2 EMC78033.1 - 0.043 13.8 0.0 0.076 13.0 0.0 1.3 1 0 0 1 1 1 0 HCMV UL42 Arf PF00025.21 EMC78034.1 - 1.3e-67 226.6 0.0 1.4e-67 226.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EMC78034.1 - 1.5e-12 47.7 0.0 2.1e-12 47.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EMC78034.1 - 2.2e-12 46.8 0.0 2.5e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EMC78034.1 - 2.3e-12 46.8 0.0 2.6e-12 46.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EMC78034.1 - 2e-09 37.2 0.0 2.5e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EMC78034.1 - 6.8e-09 35.4 0.1 2.3e-05 23.8 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 EMC78034.1 - 4.3e-08 33.2 0.0 6.2e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC78034.1 - 2.2e-05 24.1 0.0 0.0019 17.8 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EMC78034.1 - 0.0058 16.6 0.1 3.5 7.5 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase AAA_18 PF13238.6 EMC78034.1 - 0.016 15.8 0.1 0.027 15.0 0.1 1.5 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EMC78034.1 - 0.02 15.4 0.1 0.04 14.4 0.1 1.7 1 1 0 1 1 1 0 ABC transporter FeoB_N PF02421.18 EMC78034.1 - 0.056 13.0 0.1 0.16 11.5 0.1 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B PduV-EutP PF10662.9 EMC78034.1 - 0.065 13.0 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Na_Pi_cotrans PF02690.15 EMC78035.1 - 8.5e-41 139.3 24.1 1.6e-25 89.9 6.0 2.9 2 1 0 2 2 2 2 Na+/Pi-cotransporter DUF2207 PF09972.9 EMC78035.1 - 9.7 4.8 8.5 1.5e+02 0.9 8.5 2.2 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Pkinase PF00069.25 EMC78036.1 - 1.4e-67 227.8 0.0 2e-67 227.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC78036.1 - 3.3e-35 121.6 0.0 4.8e-35 121.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.19 EMC78036.1 - 7.8e-21 74.5 0.5 2.9e-20 72.7 0.1 2.1 2 0 0 2 2 2 1 Regulator of G protein signaling domain Pkinase_fungal PF17667.1 EMC78036.1 - 2.8e-05 23.1 0.0 5.4e-05 22.2 0.0 1.3 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EMC78036.1 - 7.6e-05 22.2 0.0 0.00013 21.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Cofilin_ADF PF00241.20 EMC78038.1 - 2.2e-10 40.4 0.0 4.8e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DEAD PF00270.29 EMC78039.1 - 1.5e-44 151.8 0.0 6.8e-44 149.7 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC78039.1 - 5.5e-32 110.4 0.0 3.9e-30 104.5 0.0 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain zf-CCHC PF00098.23 EMC78039.1 - 0.0013 18.7 1.5 0.0026 17.8 1.5 1.5 1 0 0 1 1 1 1 Zinc knuckle ResIII PF04851.15 EMC78039.1 - 0.033 14.2 0.0 0.14 12.2 0.0 1.9 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit UTP25 PF06862.12 EMC78039.1 - 0.12 11.2 0.0 0.37 9.5 0.0 1.7 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 CMS1 PF14617.6 EMC78039.1 - 0.23 10.8 2.0 0.59 9.4 0.0 2.2 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit ERCC3_RAD25_C PF16203.5 EMC78039.1 - 0.28 10.4 0.0 0.28 10.4 0.0 2.2 3 0 0 3 3 3 0 ERCC3/RAD25/XPB C-terminal helicase DUF3886 PF13025.6 EMC78039.1 - 9.2 6.5 18.3 4.6 7.5 4.6 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3886) Hs1pro-1_C PF07014.12 EMC78040.1 - 0.05 13.1 0.0 0.081 12.4 0.0 1.3 1 0 0 1 1 1 0 Hs1pro-1 protein C-terminus PRELI PF04707.14 EMC78041.1 - 2.5e-39 134.6 0.2 3.5e-39 134.1 0.2 1.2 1 0 0 1 1 1 1 PRELI-like family SH3_4 PF06347.13 EMC78041.1 - 0.049 13.5 0.1 0.091 12.6 0.1 1.4 1 0 0 1 1 1 0 Bacterial SH3 domain Trigger_C PF05698.14 EMC78042.1 - 0.13 12.3 0.1 0.15 12.1 0.1 1.0 1 0 0 1 1 1 0 Bacterial trigger factor protein (TF) C-terminus Pkinase_Tyr PF07714.17 EMC78044.1 - 4.2e-104 347.4 0.0 5.6e-104 347.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC78044.1 - 1.5e-44 152.4 0.0 2.2e-44 151.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.16 EMC78044.1 - 8.4e-32 109.1 0.0 2.1e-14 53.4 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC78044.1 - 3.8e-31 107.5 0.0 4e-13 49.8 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 EMC78044.1 - 8.2e-24 83.8 0.0 8.8e-10 38.8 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 EMC78044.1 - 6.1e-23 80.8 0.0 3.1e-10 40.1 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 EMC78044.1 - 2.1e-12 47.2 0.1 0.035 14.3 0.1 5.0 3 2 0 3 3 3 3 Immunoglobulin V-set domain Ig_6 PF18452.1 EMC78044.1 - 2e-07 30.4 0.0 0.026 14.1 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain Ig_5 PF16681.5 EMC78044.1 - 2.2e-05 24.7 0.0 2.1 8.8 0.0 3.8 3 0 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain FGFR3_TM PF18123.1 EMC78044.1 - 0.00033 20.1 0.8 0.00057 19.3 0.8 1.4 1 0 0 1 1 1 1 Fibroblast growth factor receptor 3 transmembrane domain Izumo-Ig PF16706.5 EMC78044.1 - 0.0068 16.4 0.0 14 5.8 0.0 3.4 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Haspin_kinase PF12330.8 EMC78044.1 - 0.04 12.8 0.0 0.077 11.9 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 EMC78044.1 - 0.057 12.2 0.0 0.085 11.6 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase C2-set_2 PF08205.12 EMC78044.1 - 0.074 13.1 0.0 0.4 10.8 0.0 2.1 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Kinase-like PF14531.6 EMC78044.1 - 0.11 11.7 0.0 0.33 10.2 0.0 1.7 2 0 0 2 2 2 0 Kinase-like RAP80_UIM PF18282.1 EMC78045.1 - 1.8e-33 114.1 11.6 1.8e-33 114.1 11.6 2.8 3 0 0 3 3 3 1 RAP80 N-terminal ubiquitin interaction motif UIM PF02809.20 EMC78045.1 - 0.002 17.9 11.4 0.034 14.1 2.3 3.0 2 0 0 2 2 2 2 Ubiquitin interaction motif zf-WRNIP1_ubi PF18279.1 EMC78045.1 - 0.081 13.6 2.1 0.36 11.6 0.1 2.7 2 0 0 2 2 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain SIR4_SID PF16991.5 EMC78045.1 - 8.6 6.4 9.2 0.46 10.5 3.3 1.9 2 0 0 2 2 2 0 Sir4 SID domain Hexokinase_2 PF03727.16 EMC78046.1 - 1.6e-141 469.7 0.2 8e-82 274.3 0.0 2.1 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.21 EMC78046.1 - 7.6e-120 398.1 0.1 4.9e-66 222.4 0.0 2.3 2 0 0 2 2 2 2 Hexokinase UPA PF17217.3 EMC78047.1 - 4.1e-69 230.9 0.1 6.8e-69 230.2 0.1 1.4 1 0 0 1 1 1 1 UPA domain ZU5 PF00791.20 EMC78047.1 - 6.1e-29 100.3 0.0 1.4e-28 99.1 0.0 1.6 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 EMC78047.1 - 3.4e-12 46.3 0.0 6.8e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 Death domain I-set PF07679.16 EMC78047.1 - 7.2e-12 45.2 0.0 3.8e-09 36.5 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC78047.1 - 1.8e-11 44.5 0.1 7.6e-08 32.9 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain TSP_1 PF00090.19 EMC78047.1 - 4.9e-11 42.7 33.8 4.4e-08 33.2 13.7 2.7 2 0 0 2 2 2 2 Thrombospondin type 1 domain Ig_2 PF13895.6 EMC78047.1 - 3.2e-05 24.2 0.0 0.00038 20.8 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 EMC78047.1 - 4.2e-05 23.6 0.0 0.028 14.6 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin domain IF4E PF01652.18 EMC78048.1 - 8.7e-58 194.6 1.4 9.7e-58 194.5 1.4 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Synuclein PF01387.17 EMC78049.1 - 1.9e-15 57.3 3.9 9.9e-15 54.9 3.9 1.8 1 1 0 1 1 1 1 Synuclein ELFV_dehydrog PF00208.21 EMC78050.1 - 1.4e-49 169.0 0.0 1.1e-47 162.8 0.0 2.1 2 0 0 2 2 2 2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 EMC78050.1 - 7.6e-38 129.3 0.0 2.2e-37 127.8 0.0 1.8 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Cadherin PF00028.17 EMC78052.1 - 3.6e-99 325.4 16.8 8.3e-17 61.4 0.2 9.5 9 1 0 9 9 9 9 Cadherin domain Cadherin_2 PF08266.12 EMC78052.1 - 3.8e-13 49.1 0.0 0.045 13.6 0.0 5.2 5 0 0 5 5 5 4 Cadherin-like Cadherin_3 PF16184.5 EMC78052.1 - 1.8e-08 34.3 18.0 0.39 10.7 0.3 8.3 8 0 0 8 8 8 5 Cadherin-like DUF5011 PF16403.5 EMC78052.1 - 0.14 12.3 2.3 4.2 7.6 0.1 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5011) UBA_4 PF14555.6 EMC78053.1 - 1.3e-07 31.3 0.2 6.9e-07 29.0 0.1 2.0 2 0 0 2 2 2 1 UBA-like domain DUF1682 PF07946.14 EMC78053.1 - 7.6e-06 25.4 8.0 1.1e-05 24.9 8.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) UBX PF00789.20 EMC78053.1 - 1.6e-05 25.0 0.2 7.9e-05 22.8 0.2 2.2 1 1 0 1 1 1 1 UBX domain CAC1F_C PF16885.5 EMC78053.1 - 0.017 14.8 2.5 0.024 14.3 2.5 1.2 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term LIM_bind PF01803.16 EMC78053.1 - 0.044 13.3 0.1 0.054 13.0 0.1 1.3 1 0 0 1 1 1 0 LIM-domain binding protein NARP1 PF12569.8 EMC78053.1 - 0.081 11.8 10.5 0.13 11.2 10.5 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 AAA_23 PF13476.6 EMC78053.1 - 0.11 13.0 10.8 0.23 11.9 10.8 1.6 1 0 0 1 1 1 0 AAA domain Serinc PF03348.15 EMC78053.1 - 0.23 10.4 0.4 0.32 9.9 0.4 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4366 PF14283.6 EMC78053.1 - 0.53 10.3 4.1 0.89 9.6 4.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Presenilin PF01080.17 EMC78053.1 - 0.88 8.3 6.6 1.3 7.8 6.6 1.1 1 0 0 1 1 1 0 Presenilin DUF5401 PF17380.2 EMC78053.1 - 1.4 6.9 20.6 2 6.4 20.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) RPN2_C PF18004.1 EMC78053.1 - 1.7 8.5 12.9 4.9 7.0 12.9 1.7 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain CDC45 PF02724.14 EMC78053.1 - 2.4 6.4 9.7 3.1 6.0 9.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Connexin PF00029.19 EMC78053.1 - 7.9 6.2 5.5 12 5.5 5.5 1.3 1 0 0 1 1 1 0 Connexin HIG_1_N PF04588.13 EMC78054.1 - 1.4e-17 63.6 4.1 2.1e-17 63.1 4.1 1.3 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Nop16 PF09420.10 EMC78055.1 - 5.7e-21 75.5 1.4 8.7e-15 55.3 1.2 2.1 1 1 1 2 2 2 2 Ribosome biogenesis protein Nop16 Baculo_p33 PF05214.12 EMC78055.1 - 0.0041 16.9 1.4 0.0053 16.5 1.4 1.2 1 0 0 1 1 1 1 Baculovirus P33 DUF3781 PF12636.7 EMC78055.1 - 0.038 13.9 1.8 0.074 12.9 1.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3781) Arf PF00025.21 EMC78056.1 - 5.4e-39 133.4 0.0 6.7e-39 133.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EMC78056.1 - 5.4e-10 39.5 0.0 8e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EMC78056.1 - 1.6e-07 30.9 0.0 1.9e-07 30.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 EMC78056.1 - 1e-06 28.4 0.0 1.2e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EMC78056.1 - 8.6e-06 25.3 0.0 1.1e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EMC78056.1 - 0.00045 20.3 0.0 0.00097 19.2 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 EMC78056.1 - 0.00078 18.7 0.0 0.0067 15.6 0.0 1.9 1 1 1 2 2 2 1 G-protein alpha subunit NACHT PF05729.12 EMC78056.1 - 0.00081 19.3 0.1 0.97 9.3 0.0 2.3 2 1 0 2 2 2 2 NACHT domain GTP_EFTU PF00009.27 EMC78056.1 - 0.0014 18.2 0.0 0.0049 16.4 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EMC78056.1 - 0.0054 17.1 2.9 0.85 10.0 0.1 2.3 1 1 0 2 2 2 2 AAA ATPase domain ABC_tran PF00005.27 EMC78056.1 - 0.14 12.7 0.0 0.15 12.6 0.0 1.4 1 1 0 1 1 1 0 ABC transporter cobW PF02492.19 EMC78056.1 - 0.17 11.5 0.0 4.1 7.0 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Peptidase_S41 PF03572.18 EMC78056.1 - 0.22 11.1 0.0 0.27 10.8 0.0 1.2 1 0 0 1 1 1 0 Peptidase family S41 P33MONOX PF15302.6 EMC78057.1 - 2.6e-134 447.5 9.0 2.9e-134 447.4 9.0 1.0 1 0 0 1 1 1 1 P33 mono-oxygenase ANAPC4_WD40 PF12894.7 EMC78059.1 - 4.7e-24 84.5 0.1 4.6e-05 23.6 0.0 5.8 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EMC78059.1 - 3.9e-21 75.0 9.0 9.9e-06 26.2 0.2 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat eIF2A PF08662.11 EMC78059.1 - 1e-12 48.3 10.6 4.9e-07 29.8 0.5 2.4 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 EMC78059.1 - 4e-06 26.6 0.0 0.0031 17.4 0.0 3.0 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 EMC78059.1 - 2.5e-05 23.5 0.1 0.0013 17.9 0.2 2.2 1 1 1 2 2 2 2 Coatomer WD associated region Nup160 PF11715.8 EMC78059.1 - 0.00073 18.3 0.1 0.0038 15.9 0.1 1.9 2 0 0 2 2 2 1 Nucleoporin Nup120/160 Peptidase_S9_N PF02897.15 EMC78059.1 - 0.0031 16.4 4.7 0.54 9.0 0.4 3.1 2 1 1 3 3 3 2 Prolyl oligopeptidase, N-terminal beta-propeller domain Ge1_WD40 PF16529.5 EMC78059.1 - 0.0034 16.4 3.0 8.7 5.2 0.0 3.8 2 2 2 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_2 PF13360.6 EMC78059.1 - 0.0049 16.5 0.1 2.1 7.9 0.0 2.2 2 0 0 2 2 2 2 PQQ-like domain Me-amine-dh_H PF06433.11 EMC78059.1 - 0.0054 15.6 0.0 0.51 9.2 0.0 2.4 2 0 0 2 2 2 1 Methylamine dehydrogenase heavy chain (MADH) RAB3GAP2_N PF14655.6 EMC78059.1 - 0.0056 16.0 0.0 0.97 8.6 0.0 2.5 2 1 1 3 3 3 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Cytochrom_D1 PF02239.16 EMC78059.1 - 0.01 14.4 0.0 0.05 12.1 0.0 1.8 1 1 1 2 2 2 0 Cytochrome D1 heme domain WDCP PF15390.6 EMC78059.1 - 0.019 13.4 1.3 0.02 13.3 0.3 1.5 2 0 0 2 2 2 0 WD repeat and coiled-coil-containing protein family 7tm_1 PF00001.21 EMC78060.1 - 9e-71 238.3 16.0 1.1e-70 237.9 16.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC78060.1 - 1.2e-12 47.8 12.4 1.5e-12 47.5 12.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC78060.1 - 1.2e-06 28.5 10.4 1.3e-05 25.1 11.9 1.9 2 1 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC78060.1 - 0.0012 18.6 14.8 0.002 17.8 14.8 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx T_cell_tran_alt PF15128.6 EMC78060.1 - 0.26 11.1 1.2 3.3 7.6 0.1 2.6 2 0 0 2 2 2 0 T-cell leukemia translocation-altered Kazal_1 PF00050.21 EMC78061.1 - 8.7e-16 57.7 4.7 1e-15 57.5 4.7 1.1 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 EMC78061.1 - 3.2e-08 33.6 1.0 4.1e-08 33.2 1.0 1.2 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EMC78062.1 - 5.4e-129 420.1 74.6 2.3e-20 72.3 4.9 7.1 7 0 0 7 7 7 7 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 EMC78062.1 - 1.3e-64 214.1 57.6 9.9e-10 38.4 2.1 7.4 7 0 0 7 7 7 7 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EMC78063.1 - 9.5e-46 153.6 28.8 4.4e-19 68.2 6.7 3.1 3 0 0 3 3 3 3 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 EMC78063.1 - 1.9e-23 82.3 24.9 4.5e-09 36.3 5.4 3.3 3 0 0 3 3 3 3 Kazal-type serine protease inhibitor domain DUF393 PF04134.12 EMC78063.1 - 0.72 11.2 8.9 23 6.4 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function, DUF393 Kazal_1 PF00050.21 EMC78064.1 - 1.9e-12 46.9 5.0 2.2e-12 46.8 5.0 1.1 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 EMC78064.1 - 2.9e-05 24.1 2.5 4e-05 23.7 2.5 1.2 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EMC78065.1 - 2.8e-18 65.7 4.2 3.1e-18 65.5 4.2 1.0 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 EMC78065.1 - 2.8e-09 36.9 3.0 3.6e-09 36.6 3.0 1.2 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain NIF PF03031.18 EMC78066.1 - 1.7e-30 105.8 0.2 2.6e-30 105.2 0.2 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase ubiquitin PF00240.23 EMC78066.1 - 7e-08 32.1 0.1 1.6e-07 31.0 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin family DUF705 PF05152.12 EMC78066.1 - 0.0017 17.9 0.1 0.0028 17.2 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF705) Ubiquitin_2 PF14560.6 EMC78066.1 - 0.013 16.0 0.1 0.034 14.6 0.1 1.7 1 0 0 1 1 1 0 Ubiquitin-like domain COE1_HLH PF16423.5 EMC78068.1 - 5.1e-37 125.3 3.0 3.7e-30 103.4 0.4 2.4 2 0 0 2 2 2 2 Transcription factor COE1 helix-loop-helix domain COE1_DBD PF16422.5 EMC78068.1 - 7.4e-34 117.2 2.5 1e-33 116.7 2.5 1.2 1 0 0 1 1 1 1 Transcription factor COE1 DNA-binding domain TIG PF01833.24 EMC78068.1 - 3.1e-12 46.4 0.3 3.1e-12 46.4 0.3 2.4 3 0 0 3 3 3 1 IPT/TIG domain HLH PF00010.26 EMC78068.1 - 0.1 12.6 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain ENTH PF01417.20 EMC78069.1 - 2.1e-45 153.8 0.2 4.2e-45 152.8 0.0 1.6 2 0 0 2 2 2 1 ENTH domain ANTH PF07651.16 EMC78069.1 - 4.1e-05 22.7 0.0 6.2e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 ANTH domain LSM PF01423.22 EMC78070.1 - 6.9e-10 38.5 0.1 5.6e-05 22.8 0.0 2.3 2 0 0 2 2 2 2 LSM domain Thg1C PF14413.6 EMC78071.1 - 1.6e-49 167.1 0.2 2.8e-49 166.3 0.2 1.4 1 0 0 1 1 1 1 Thg1 C terminal domain Thg1 PF04446.12 EMC78071.1 - 1.9e-47 160.4 0.0 2.8e-47 159.8 0.0 1.2 1 0 0 1 1 1 1 tRNAHis guanylyltransferase HMG_box PF00505.19 EMC78072.1 - 3.8e-23 81.7 1.3 6.8e-23 80.9 1.3 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC78072.1 - 1.4e-10 41.6 0.5 2.3e-10 40.9 0.5 1.3 1 0 0 1 1 1 1 HMG-box domain Reprolysin PF01421.19 EMC78073.1 - 4e-63 212.9 0.0 4e-63 212.9 0.0 1.7 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 EMC78073.1 - 5.2e-32 110.7 7.3 5.2e-32 110.7 7.3 3.9 3 1 0 3 3 3 1 ADAM cysteine-rich Reprolysin_5 PF13688.6 EMC78073.1 - 4.7e-23 82.4 0.5 4.7e-23 82.4 0.5 1.9 2 0 0 2 2 2 1 Metallo-peptidase family M12 Disintegrin PF00200.23 EMC78073.1 - 2.1e-19 70.1 27.6 2.1e-19 70.1 27.6 5.0 4 1 0 4 4 4 1 Disintegrin Pep_M12B_propep PF01562.19 EMC78073.1 - 5.4e-18 65.6 0.1 9.9e-18 64.7 0.1 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_3 PF13582.6 EMC78073.1 - 3.6e-16 59.8 0.1 8.5e-16 58.6 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EMC78073.1 - 1.5e-11 44.5 0.1 3.5e-11 43.4 0.1 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EMC78073.1 - 3.9e-10 39.7 0.1 7.4e-10 38.8 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.13 EMC78073.1 - 0.0033 17.8 14.2 0.0033 17.8 14.2 6.3 6 2 0 6 6 6 1 EGF-like domain Peptidase_M66 PF10462.9 EMC78073.1 - 0.13 11.2 0.2 0.21 10.5 0.2 1.2 1 0 0 1 1 1 0 Peptidase M66 Mg_trans_NIPA PF05653.14 EMC78074.1 - 7.4e-130 432.3 16.3 8.6e-130 432.1 16.3 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EMC78074.1 - 6.9e-08 32.8 4.4 6.9e-08 32.8 4.4 3.6 3 1 1 4 4 4 1 EamA-like transporter family K1 PF02960.14 EMC78074.1 - 0.024 14.7 2.1 0.024 14.7 2.1 2.8 2 2 1 3 3 3 0 K1 glycoprotein Ctr PF04145.15 EMC78074.1 - 0.36 11.4 0.1 0.36 11.4 0.1 2.2 3 0 0 3 3 3 0 Ctr copper transporter family fn3 PF00041.21 EMC78075.1 - 4.8e-05 23.6 0.1 8e-05 22.9 0.1 1.3 1 0 0 1 1 1 1 Fibronectin type III domain Pkinase_Tyr PF07714.17 EMC78076.1 - 2e-91 305.8 0.0 2.8e-91 305.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC78076.1 - 9.1e-50 169.5 0.0 1.4e-49 168.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 EMC78076.1 - 1.8e-21 76.0 0.0 4e-21 74.9 0.0 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 EMC78076.1 - 2.2e-15 56.0 0.3 4.6e-15 54.9 0.3 1.6 1 0 0 1 1 1 1 SH3 domain PH PF00169.29 EMC78076.1 - 1.6e-13 51.0 1.5 2.9e-13 50.2 0.6 2.0 2 0 0 2 2 2 1 PH domain SH3_9 PF14604.6 EMC78076.1 - 3.5e-13 49.2 0.4 7.7e-13 48.1 0.4 1.6 1 0 0 1 1 1 1 Variant SH3 domain BTK PF00779.19 EMC78076.1 - 8.9e-13 47.8 3.4 1.6e-12 47.0 3.4 1.5 1 0 0 1 1 1 1 BTK motif SH3_2 PF07653.17 EMC78076.1 - 9.8e-08 31.6 0.0 2.1e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 EMC78076.1 - 6e-05 23.2 0.3 0.00019 21.7 0.3 1.9 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_10 PF17902.1 EMC78076.1 - 8.2e-05 22.6 0.0 0.00025 21.1 0.0 1.8 1 0 0 1 1 1 1 SH3 domain PH_8 PF15409.6 EMC78076.1 - 0.001 19.3 0.5 0.0038 17.5 0.5 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain SH3_4 PF06347.13 EMC78076.1 - 0.019 14.8 0.1 0.041 13.7 0.1 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain Neprosin PF03080.15 EMC78076.1 - 0.073 12.4 0.2 0.21 10.9 0.2 1.8 2 0 0 2 2 2 0 Neprosin Kinase-like PF14531.6 EMC78076.1 - 0.11 11.8 0.0 0.46 9.8 0.0 1.9 2 0 0 2 2 2 0 Kinase-like PH_11 PF15413.6 EMC78076.1 - 0.55 10.7 4.9 1.2 9.5 2.6 2.7 2 1 0 2 2 2 0 Pleckstrin homology domain Med7 PF05983.11 EMC78077.1 - 3.9e-46 157.6 7.7 3.1e-45 154.6 7.7 1.9 1 1 0 1 1 1 1 MED7 protein DUF2489 PF10675.9 EMC78077.1 - 0.024 14.6 0.2 0.065 13.2 0.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2489) DotU PF09850.9 EMC78077.1 - 0.14 11.9 1.4 9.2 5.9 0.4 2.2 2 0 0 2 2 2 0 Type VI secretion system protein DotU V-set PF07686.17 EMC78078.1 - 5e-17 62.1 0.1 8.7e-17 61.3 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 EMC78078.1 - 0.00015 21.9 0.0 0.0011 19.1 0.1 2.3 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 EMC78078.1 - 0.0027 17.7 0.0 0.006 16.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC78078.1 - 0.0039 17.8 1.2 0.02 15.5 0.3 2.7 2 1 0 2 2 2 1 Immunoglobulin domain Stevor PF17410.2 EMC78078.1 - 0.029 13.9 0.0 0.045 13.3 0.0 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Ig_2 PF13895.6 EMC78078.1 - 0.035 14.4 0.8 0.2 12.0 0.8 2.2 1 1 0 1 1 1 0 Immunoglobulin domain Sarcoglycan_1 PF04790.13 EMC78079.1 - 4.3e-81 272.1 0.0 5e-81 271.9 0.0 1.0 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein DUF2345 PF10106.9 EMC78079.1 - 0.00022 21.1 0.0 0.002 18.0 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2345) DUF1523 PF07509.11 EMC78079.1 - 0.085 12.2 0.1 0.17 11.2 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1523) Ribosomal_L22 PF00237.19 EMC78080.1 - 1.4e-23 83.1 0.6 2e-23 82.5 0.3 1.4 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e CAF1 PF04857.20 EMC78081.1 - 1.5e-23 83.5 1.6 1.1e-11 44.5 0.1 2.4 1 1 0 2 2 2 2 CAF1 family ribonuclease FA_hydroxylase PF04116.13 EMC78082.1 - 7.2e-21 74.9 15.2 7.2e-21 74.9 15.2 2.8 3 1 1 4 4 4 1 Fatty acid hydroxylase superfamily La PF05383.17 EMC78084.1 - 1.4e-21 76.3 0.8 3.5e-21 75.0 0.2 2.1 2 0 0 2 2 2 1 La domain DUF5320 PF17253.2 EMC78084.1 - 0.83 10.8 6.9 0.89 10.7 4.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5320) SGP PF17228.2 EMC78084.1 - 6.4 7.7 11.6 0.31 11.9 5.2 2.1 2 0 0 2 2 2 0 Sulphur globule protein zf-SAP30 PF13866.6 EMC78086.1 - 2.4e-38 130.1 3.9 4.5e-38 129.2 3.9 1.5 1 0 0 1 1 1 1 SAP30 zinc-finger SAP30_Sin3_bdg PF13867.6 EMC78086.1 - 8.4e-26 90.1 0.7 1.5e-25 89.3 0.7 1.4 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 Glycos_transf_2 PF00535.26 EMC78087.1 - 3.5e-34 118.0 0.0 5.8e-34 117.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 EMC78087.1 - 4.4e-27 94.8 0.7 6.9e-27 94.2 0.7 1.2 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 EMC78087.1 - 4.1e-06 26.4 0.3 1.1e-05 25.0 0.3 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 EMC78087.1 - 0.00029 20.4 0.0 0.00088 18.8 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.6 EMC78087.1 - 0.00089 19.9 0.1 3.1 8.6 0.0 2.8 2 1 1 3 3 3 2 Ricin-type beta-trefoil lectin domain-like ig PF00047.25 EMC78088.1 - 1.5e-07 31.5 0.0 2.9e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC78088.1 - 3.5e-06 27.5 0.0 8.4e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC78088.1 - 5.5e-06 26.4 0.0 1.1e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 EMC78088.1 - 3.8e-05 23.8 0.1 0.0041 17.3 0.1 2.6 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.6 EMC78088.1 - 0.017 15.5 0.0 0.038 14.3 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain DUF719 PF05334.13 EMC78089.1 - 1e-70 237.8 2.1 1e-70 237.8 2.1 3.1 3 1 0 3 3 3 1 Protein of unknown function (DUF719) RLL PF10036.9 EMC78089.1 - 0.36 10.6 8.9 0.021 14.7 3.0 2.0 2 1 0 2 2 2 0 RNA transcription, translation and transport factor protein DUF755 PF05501.11 EMC78090.1 - 0.022 15.0 21.8 0.027 14.7 21.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Kei1 PF08552.11 EMC78090.1 - 5.5 6.8 8.3 6.3 6.6 8.3 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 TFIIF_alpha PF05793.12 EMC78090.1 - 6.6 5.2 43.6 7.5 5.0 43.6 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) FAM60A PF15396.6 EMC78090.1 - 8.7 6.3 19.7 9.6 6.1 19.7 1.0 1 0 0 1 1 1 0 Protein Family FAM60A LON_substr_bdg PF02190.16 EMC78091.1 - 7.7e-22 78.2 0.0 1.2e-21 77.6 0.0 1.3 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain zf-C3HC4_2 PF13923.6 EMC78091.1 - 1.6e-14 53.4 34.3 2.2e-09 37.0 14.7 3.3 2 1 1 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMC78091.1 - 1.1e-12 47.6 23.0 1.4e-08 34.5 10.1 2.8 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC78091.1 - 4.7e-12 45.7 27.2 5.9e-06 26.2 5.8 2.8 2 0 0 2 2 2 2 zinc-RING finger domain zf-RING_UBOX PF13445.6 EMC78091.1 - 3.5e-11 42.9 28.7 4.9e-06 26.5 8.9 4.1 2 2 2 4 4 4 2 RING-type zinc-finger zf-C3HC4 PF00097.25 EMC78091.1 - 2.8e-10 39.9 32.4 1.3e-06 28.2 14.1 3.5 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMC78091.1 - 8.5e-10 38.6 27.8 2.4e-05 24.4 7.1 3.4 2 1 1 3 3 3 2 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EMC78091.1 - 1.4e-09 37.7 27.5 4.7e-05 23.2 11.1 2.7 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EMC78091.1 - 1.7e-07 31.5 37.4 1e-06 29.0 14.3 3.6 3 0 0 3 3 3 2 Ring finger domain TPR_2 PF07719.17 EMC78091.1 - 2e-07 30.6 1.4 0.12 12.6 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMC78091.1 - 2.9e-07 30.0 0.5 0.026 14.3 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMC78091.1 - 1.4e-06 28.6 7.2 0.0024 18.5 0.1 4.3 2 1 2 4 4 3 2 Tetratricopeptide repeat zf-RING_10 PF16685.5 EMC78091.1 - 6.9e-06 26.1 22.1 0.003 17.7 7.4 2.7 2 0 0 2 2 2 2 zinc RING finger of MSL2 TPR_9 PF13371.6 EMC78091.1 - 8.6e-06 25.8 5.7 0.0045 17.1 1.2 4.0 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMC78091.1 - 0.00033 20.6 0.0 0.39 11.0 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat zf-RING_6 PF14835.6 EMC78091.1 - 0.00047 20.0 21.8 0.042 13.7 6.4 3.0 3 0 0 3 3 3 2 zf-RING of BARD1-type protein BTAD PF03704.17 EMC78091.1 - 0.0019 18.7 4.1 0.011 16.2 0.4 2.4 1 1 1 2 2 2 1 Bacterial transcriptional activator domain zf-rbx1 PF12678.7 EMC78091.1 - 0.0037 17.5 9.2 0.0037 17.5 9.2 3.0 2 0 0 2 2 2 1 RING-H2 zinc finger domain TPR_19 PF14559.6 EMC78091.1 - 0.0057 17.1 0.3 0.25 11.9 0.2 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat U-box PF04564.15 EMC78091.1 - 0.01 16.0 0.1 0.036 14.2 0.0 1.9 2 0 0 2 2 1 0 U-box domain TPR_16 PF13432.6 EMC78091.1 - 0.012 16.2 2.9 0.012 16.2 2.9 1.9 2 0 0 2 2 1 0 Tetratricopeptide repeat TPR_17 PF13431.6 EMC78091.1 - 0.016 15.5 0.2 0.75 10.3 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMC78091.1 - 0.018 15.7 0.1 27 5.7 0.0 3.8 4 0 0 4 4 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC78091.1 - 0.052 13.8 1.3 0.12 12.6 0.1 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 ChAPs PF09295.10 EMC78091.1 - 0.13 11.2 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_12 PF13424.6 EMC78091.1 - 0.5 10.7 4.9 40 4.6 0.0 3.3 1 1 0 2 2 2 0 Tetratricopeptide repeat DUF1272 PF06906.11 EMC78091.1 - 1.2 9.2 19.1 2.5 8.3 0.8 3.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1272) zf-RING_4 PF14570.6 EMC78091.1 - 7.8 6.4 23.2 0.12 12.1 5.9 3.2 3 0 0 3 3 2 0 RING/Ubox like zinc-binding domain ANF_receptor PF01094.28 EMC78092.1 - 4.6e-68 229.9 0.0 6.9e-68 229.3 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.26 EMC78092.1 - 1.4e-60 203.5 0.1 2.2e-60 202.8 0.1 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 EMC78092.1 - 1.2e-44 151.2 0.0 3e-44 149.9 0.0 1.7 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 EMC78092.1 - 1.3e-23 83.6 0.0 2.6e-23 82.6 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 DUF659 PF04937.15 EMC78092.1 - 0.0065 16.3 0.1 0.018 14.9 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) Ion_trans_2 PF07885.16 EMC78092.1 - 3.9 7.5 7.5 4.8 7.2 0.1 3.5 3 0 0 3 3 3 0 Ion channel 7tm_1 PF00001.21 EMC78093.1 - 4.8e-51 173.6 17.8 7.4e-51 173.0 17.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC78093.1 - 1.1e-10 41.4 16.8 2.1e-10 40.4 16.8 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC78093.1 - 2.4e-05 24.1 24.8 7e-05 22.6 23.5 2.6 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.9 EMC78093.1 - 6.7e-05 22.3 16.3 0.0029 17.0 16.3 2.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.6 EMC78093.1 - 0.00031 20.6 15.0 0.0019 18.0 15.0 2.0 1 1 0 1 1 1 1 Olfactory receptor DUF5381 PF17353.2 EMC78093.1 - 7.8 6.2 10.4 2.3 7.9 1.4 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5381) Neur_chan_LBD PF02931.23 EMC78094.1 - 1.1e-53 181.9 0.0 1.4e-53 181.6 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC78094.1 - 1.1e-39 137.0 0.0 9.6e-33 114.2 0.0 2.2 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region NTF2 PF02136.20 EMC78095.1 - 3.8e-23 82.3 0.1 7.5e-23 81.4 0.1 1.5 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 EMC78095.1 - 2.6e-10 40.0 0.1 3.2e-09 36.5 0.1 2.2 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMC78095.1 - 5.8e-05 23.1 0.0 0.00018 21.6 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif HMA PF00403.26 EMC78096.1 - 2e-10 41.0 0.1 2.3e-10 40.8 0.1 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain RXLR_WY PF18634.1 EMC78096.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 RXLR phytopathogen effector protein WY-domain SPARC_Ca_bdg PF10591.9 EMC78097.1 - 6.1e-41 139.3 0.6 1.4e-40 138.1 0.6 1.6 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Kazal_1 PF00050.21 EMC78097.1 - 2.9e-15 56.0 7.8 1.3e-14 53.9 4.9 2.7 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 EMC78097.1 - 3.8e-12 46.1 2.6 3.8e-12 46.1 2.6 3.1 3 0 0 3 3 3 1 Kazal-type serine protease inhibitor domain FOLN PF09289.10 EMC78097.1 - 5.2e-09 36.1 9.5 5.2e-09 36.1 9.5 2.1 2 0 0 2 2 2 1 Follistatin/Osteonectin-like EGF domain EF-hand_1 PF00036.32 EMC78097.1 - 0.028 14.0 0.1 0.25 11.0 0.1 2.4 2 0 0 2 2 2 0 EF hand hEGF PF12661.7 EMC78097.1 - 0.035 14.7 3.2 0.12 13.0 3.2 2.0 1 1 0 1 1 1 0 Human growth factor-like EGF DUF4801 PF16059.5 EMC78097.1 - 0.035 14.0 7.5 0.091 12.7 7.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4801) EF-hand_6 PF13405.6 EMC78097.1 - 0.11 12.5 0.1 0.51 10.4 0.1 2.1 2 0 0 2 2 2 0 EF-hand domain EF-hand_7 PF13499.6 EMC78097.1 - 0.47 10.9 2.1 2.8 8.5 0.2 2.8 2 1 1 3 3 3 0 EF-hand domain pair Cadherin PF00028.17 EMC78098.1 - 0 1583.2 45.7 4.2e-23 81.6 0.0 33.8 34 0 0 34 34 34 33 Cadherin domain Cadherin_2 PF08266.12 EMC78098.1 - 4.8e-21 74.4 0.1 0.3 11.0 0.0 17.7 23 0 0 23 23 23 2 Cadherin-like Cadherin_3 PF16184.5 EMC78098.1 - 6e-21 74.5 46.1 0.047 13.7 0.1 20.0 21 1 1 22 22 22 7 Cadherin-like RET_CLD1 PF17756.1 EMC78098.1 - 1.7e-17 63.9 0.0 0.22 11.8 0.0 15.3 16 1 1 17 17 16 1 RET Cadherin like domain 1 Laminin_G_2 PF02210.24 EMC78098.1 - 6e-17 62.4 0.2 2.9e-16 60.2 0.2 2.4 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 EMC78098.1 - 9.9e-11 42.0 0.0 3.8e-10 40.1 0.0 2.1 1 0 0 1 1 1 1 Laminin G domain EGF PF00008.27 EMC78098.1 - 1.2e-09 38.3 32.0 0.00012 22.3 9.9 3.8 3 0 0 3 3 3 2 EGF-like domain Laminin_G_3 PF13385.6 EMC78098.1 - 0.0022 18.2 0.4 0.03 14.4 0.1 3.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Cadherin_4 PF17803.1 EMC78098.1 - 0.0093 16.6 107.8 0.077 13.6 1.2 19.4 21 0 0 21 21 21 5 Bacterial cadherin-like domain Y_Y_Y PF07495.13 EMC78098.1 - 0.017 15.0 0.0 1.1e+02 2.9 0.0 6.3 6 0 0 6 6 6 0 Y_Y_Y domain hEGF PF12661.7 EMC78098.1 - 0.033 14.8 25.7 0.052 14.2 5.0 3.4 3 0 0 3 3 3 0 Human growth factor-like EGF FlgD_ig PF13860.6 EMC78098.1 - 0.064 13.1 0.0 0.68 9.8 0.0 3.1 1 0 0 1 1 1 0 FlgD Ig-like domain EGF_2 PF07974.13 EMC78098.1 - 0.072 13.5 28.2 3.5 8.1 10.2 3.8 2 1 0 2 2 2 0 EGF-like domain Podovirus_Gp16 PF05894.12 EMC78098.1 - 0.14 11.6 0.2 22 4.4 0.0 3.4 4 0 0 4 4 4 0 Podovirus DNA encapsidation protein (Gp16) DUF4394 PF14339.6 EMC78098.1 - 3.3 7.0 8.7 4.9 6.4 0.1 5.6 7 0 0 7 7 7 0 Domain of unknown function (DUF4394) E1_DerP2_DerF2 PF02221.15 EMC78100.1 - 1.4e-27 96.8 0.1 1.6e-27 96.5 0.1 1.1 1 0 0 1 1 1 1 ML domain CRISPR_Cas9_WED PF18061.1 EMC78101.1 - 0.022 14.8 1.0 0.029 14.4 1.0 1.1 1 0 0 1 1 1 0 CRISPR-Cas9 WED domain Nuc_N PF14448.6 EMC78101.1 - 0.14 12.1 2.7 0.43 10.5 1.6 2.4 2 1 0 2 2 2 0 Nuclease N terminal RICH PF05062.12 EMC78101.1 - 0.15 12.4 5.6 0.21 11.9 5.3 1.6 1 1 0 1 1 1 0 RICH domain FapA PF03961.13 EMC78101.1 - 0.2 10.3 9.4 0.21 10.1 9.4 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Spectrin PF00435.21 EMC78101.1 - 0.28 11.7 14.6 0.73 10.3 14.5 1.9 1 1 0 1 1 1 0 Spectrin repeat Plk4_PB2 PF18409.1 EMC78101.1 - 0.34 11.6 3.9 0.36 11.5 2.9 1.5 1 1 0 1 1 1 0 Polo-like Kinase 4 Polo Box 2 DUF1690 PF07956.11 EMC78101.1 - 0.35 11.3 15.2 0.83 10.1 14.7 1.7 1 1 0 1 1 1 0 Protein of Unknown function (DUF1690) ARA70 PF12489.8 EMC78101.1 - 0.57 10.4 8.5 4.5 7.5 8.5 2.0 1 1 0 1 1 1 0 Nuclear coactivator ARD PF03079.14 EMC78101.1 - 1.3 9.2 7.5 0.38 10.9 2.8 1.9 1 1 1 2 2 2 0 ARD/ARD' family FlxA PF14282.6 EMC78101.1 - 3 7.9 15.3 0.092 12.7 6.3 2.2 1 1 1 2 2 2 0 FlxA-like protein TMPIT PF07851.13 EMC78101.1 - 5.7 6.1 8.1 6 6.0 8.1 1.3 1 0 0 1 1 1 0 TMPIT-like protein DUF4140 PF13600.6 EMC78101.1 - 8.9 6.8 15.0 1.8 9.0 1.0 2.6 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Annexin PF00191.20 EMC78102.1 - 1.8e-189 614.2 33.9 3.5e-25 87.9 0.4 8.1 8 0 0 8 8 8 8 Annexin DUF5069 PF16798.5 EMC78102.1 - 0.002 18.4 0.1 0.82 9.9 0.0 3.9 4 0 0 4 4 4 1 Domain of unknown function (DUF5069) Myb_DNA-bind_7 PF15963.5 EMC78102.1 - 0.002 18.0 0.5 11 6.0 0.0 5.9 7 1 1 8 8 8 1 Myb DNA-binding like GGDEF_2 PF17853.1 EMC78102.1 - 0.0033 17.7 0.3 0.05 13.9 0.1 3.0 3 1 0 3 3 3 1 GGDEF-like domain Sigma70_ner PF04546.13 EMC78102.1 - 0.031 14.2 8.0 12 5.7 0.3 3.9 2 2 0 3 3 3 0 Sigma-70, non-essential region RuvC PF02075.17 EMC78102.1 - 0.032 14.1 0.0 33 4.3 0.0 3.5 3 0 0 3 3 3 0 Crossover junction endodeoxyribonuclease RuvC DUF3574 PF12098.8 EMC78102.1 - 0.25 11.2 1.0 20 5.0 0.1 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF3574) DUF2255 PF10012.9 EMC78102.1 - 4.7 7.4 6.0 66 3.7 0.1 4.0 5 0 0 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2255) GSHPx PF00255.19 EMC78103.1 - 1.4e-23 82.5 0.1 1.9e-23 82.1 0.1 1.2 1 0 0 1 1 1 1 Glutathione peroxidase Dynactin_p62 PF05502.13 EMC78104.1 - 2.5e-27 95.8 19.7 4e-15 55.6 3.8 2.5 1 1 1 2 2 2 2 Dynactin p62 family Elf1 PF05129.13 EMC78104.1 - 0.15 12.2 7.3 0.41 10.7 4.3 2.6 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like RRM_1 PF00076.22 EMC78105.1 - 1.2e-10 41.0 0.1 2e-10 40.4 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 EMC78105.1 - 2.9e-06 27.1 1.8 2.9e-06 27.1 1.8 2.1 2 0 0 2 2 2 1 Zinc finger domain Torus PF16131.5 EMC78105.1 - 4.5e-06 27.3 0.2 1.5e-05 25.7 0.0 1.9 2 0 0 2 2 2 1 Torus domain Nup35_RRM_2 PF14605.6 EMC78105.1 - 1.9e-05 24.5 0.0 3.7e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EMC78105.1 - 0.00014 21.7 0.0 0.00025 20.8 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_3 PF08777.11 EMC78105.1 - 0.0019 18.2 0.0 0.0042 17.1 0.0 1.5 1 0 0 1 1 1 1 RNA binding motif zf-CCCH PF00642.24 EMC78105.1 - 0.002 18.0 1.8 0.002 18.0 1.8 2.6 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EMC78105.1 - 0.0061 16.3 1.8 0.014 15.2 1.8 1.7 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EMC78105.1 - 0.0099 16.1 0.6 0.021 15.0 0.2 1.7 2 0 0 2 2 2 1 Zinc-finger containing family FYVE PF01363.21 EMC78105.1 - 0.011 15.9 0.6 0.011 15.9 0.6 1.8 2 0 0 2 2 2 0 FYVE zinc finger zf-CCCH_2 PF14608.6 EMC78105.1 - 0.012 16.0 0.5 0.012 16.0 0.5 2.1 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger zinc-ribbons_6 PF07191.12 EMC78105.1 - 2 8.5 9.2 4.8 7.2 9.2 1.7 1 0 0 1 1 1 0 zinc-ribbons Calsarcin PF05556.11 EMC78106.1 - 2.6e-40 138.6 0.0 1.1e-39 136.5 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-binding protein (Calsarcin) HSNSD PF12062.8 EMC78108.1 - 3.8e-257 853.8 0.0 4.9e-257 853.4 0.0 1.1 1 0 0 1 1 1 1 heparan sulfate-N-deacetylase Sulfotransfer_1 PF00685.27 EMC78108.1 - 4e-46 157.7 0.0 6.3e-46 157.0 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC78108.1 - 2.2e-06 28.2 0.2 0.0047 17.3 0.0 2.5 1 1 1 2 2 2 2 Sulfotransferase family Ribosomal_S11 PF00411.19 EMC78109.1 - 3.2e-41 140.1 0.1 4.6e-41 139.6 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S11 CBM_25 PF03423.13 EMC78109.1 - 0.09 13.0 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) MHC2-interact PF09307.10 EMC78110.1 - 3.9e-36 123.4 2.3 7.7e-36 122.4 2.3 1.5 1 0 0 1 1 1 1 CLIP, MHC2 interacting MHCassoc_trimer PF08831.10 EMC78110.1 - 3e-32 110.4 9.6 4.8e-32 109.8 9.6 1.3 1 0 0 1 1 1 1 Class II MHC-associated invariant chain trimerisation domain Thyroglobulin_1 PF00086.18 EMC78110.1 - 1.6e-14 53.3 6.1 3e-14 52.4 6.1 1.4 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat Treacle PF03546.14 EMC78111.1 - 2.3e-07 30.1 89.1 6.3e-07 28.6 18.2 7.0 1 1 5 6 6 6 4 Treacher Collins syndrome protein Treacle Sulfatase PF00884.23 EMC78112.1 - 1.4e-70 238.2 0.1 1.9e-70 237.7 0.1 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 EMC78112.1 - 0.022 15.5 0.0 0.18 12.6 0.0 2.3 2 0 0 2 2 2 0 C-terminal region of aryl-sulfatase Pkinase PF00069.25 EMC78113.1 - 4.9e-75 252.3 0.0 1.3e-74 250.9 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain CaMKII_AD PF08332.10 EMC78113.1 - 1.9e-64 215.6 0.0 3.2e-64 214.8 0.0 1.4 1 0 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II association domain Pkinase_Tyr PF07714.17 EMC78113.1 - 1.3e-32 113.1 0.0 2.1e-32 112.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase SnoaL_3 PF13474.6 EMC78113.1 - 7.2e-09 36.0 0.0 1.4e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 EMC78113.1 - 3.1e-08 34.0 0.0 5.7e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) Pkinase_fungal PF17667.1 EMC78113.1 - 0.0016 17.3 0.0 0.0046 15.8 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EMC78113.1 - 0.0018 18.2 0.4 0.81 9.6 0.2 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EMC78113.1 - 0.006 16.0 0.1 0.012 15.0 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SnoaL_2 PF12680.7 EMC78113.1 - 0.033 14.8 0.0 0.069 13.8 0.0 1.5 1 0 0 1 1 1 0 SnoaL-like domain FTA2 PF13095.6 EMC78113.1 - 0.061 12.9 0.1 1.7 8.3 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 SnoaL_4 PF13577.6 EMC78113.1 - 0.073 13.2 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 SnoaL-like domain SNF PF00209.18 EMC78115.1 - 9.3e-223 740.6 35.9 1.3e-222 740.2 35.9 1.2 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Phage_holin_2_3 PF16080.5 EMC78115.1 - 6.1 6.7 6.3 0.61 9.9 0.1 2.5 2 0 0 2 2 2 0 Bacteriophage holin family HP1 Caudal_act PF04731.12 EMC78116.1 - 2e-42 144.8 15.9 2e-42 144.8 15.9 1.4 2 0 0 2 2 2 1 Caudal like protein activation region Homeodomain PF00046.29 EMC78116.1 - 4.3e-21 74.5 2.3 7e-21 73.8 2.3 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC78116.1 - 0.0026 17.6 0.4 0.0061 16.4 0.4 1.6 1 0 0 1 1 1 1 Homeobox KN domain YdaS_antitoxin PF15943.5 EMC78116.1 - 0.15 12.0 0.1 0.26 11.2 0.1 1.3 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Pkinase_Tyr PF07714.17 EMC78117.1 - 3.8e-108 360.7 0.0 5.9e-108 360.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC78117.1 - 3.8e-44 151.0 0.0 5.3e-27 94.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.6 EMC78117.1 - 5.8e-29 100.5 6.9 4.5e-10 40.0 0.0 5.7 4 1 1 5 5 5 4 Immunoglobulin domain I-set PF07679.16 EMC78117.1 - 1.6e-27 95.4 3.7 2.1e-10 40.5 0.1 4.8 4 1 0 4 4 4 4 Immunoglobulin I-set domain ig PF00047.25 EMC78117.1 - 6.2e-22 77.6 3.1 1.4e-07 31.6 0.0 5.8 5 1 0 5 5 5 3 Immunoglobulin domain Ig_2 PF13895.6 EMC78117.1 - 4.6e-19 68.5 10.2 1.1e-10 41.6 0.1 6.0 5 2 1 6 6 6 3 Immunoglobulin domain V-set PF07686.17 EMC78117.1 - 2.4e-06 27.7 7.9 0.0011 19.1 0.4 5.2 4 1 0 4 4 4 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC78117.1 - 7.2e-05 22.8 7.3 0.43 10.7 0.1 4.5 4 1 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 EMC78117.1 - 0.00023 21.5 2.1 0.31 11.5 0.1 4.6 4 2 0 4 4 4 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Adeno_E3_CR1 PF02440.15 EMC78117.1 - 0.00024 20.8 0.3 2.6 7.9 0.0 3.8 3 0 0 3 3 3 1 Adenovirus E3 region protein CR1 Ig_6 PF18452.1 EMC78117.1 - 0.0097 15.5 0.0 0.63 9.6 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain Pkinase_Tyr PF07714.17 EMC78118.1 - 5.2e-107 356.9 0.0 7.6e-107 356.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC78118.1 - 6.4e-43 147.0 0.0 3.8e-27 95.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.6 EMC78118.1 - 2.8e-27 95.1 4.7 1.6e-05 25.4 0.3 5.6 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 EMC78118.1 - 1e-23 83.2 0.1 0.00042 20.3 0.0 6.0 6 1 0 6 6 6 5 Immunoglobulin I-set domain ig PF00047.25 EMC78118.1 - 3.8e-18 65.4 9.6 9.4e-07 28.9 0.0 5.1 5 1 0 5 5 5 3 Immunoglobulin domain Ig_2 PF13895.6 EMC78118.1 - 9.3e-17 61.1 4.0 2.5e-05 24.5 0.1 4.7 4 0 0 4 4 4 3 Immunoglobulin domain Ig_4 PF16680.5 EMC78118.1 - 1.1e-07 32.0 0.2 0.00017 21.8 0.0 3.2 3 0 0 3 3 3 2 T-cell surface glycoprotein CD3 delta chain V-set PF07686.17 EMC78118.1 - 9.5e-07 29.0 10.5 0.026 14.7 0.2 6.8 6 2 1 7 7 7 2 Immunoglobulin V-set domain Izumo-Ig PF16706.5 EMC78118.1 - 0.00059 19.8 0.2 3 7.9 0.0 3.7 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain APH PF01636.23 EMC78118.1 - 0.0062 16.5 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family C2-set PF05790.15 EMC78118.1 - 0.015 15.4 1.9 6.7 7.0 0.1 3.6 5 0 0 5 5 4 0 Immunoglobulin C2-set domain Invasin_D3 PF09134.10 EMC78118.1 - 0.061 13.6 0.0 9.5 6.6 0.0 3.3 3 0 0 3 3 3 0 Invasin, domain 3 HMG_box_2 PF09011.10 EMC78119.1 - 6.6e-12 45.9 0.4 1.5e-11 44.8 0.4 1.6 1 0 0 1 1 1 1 HMG-box domain CxC4 PF18717.1 EMC78119.1 - 2e-11 43.9 0.2 6.5e-11 42.2 0.2 1.9 1 0 0 1 1 1 1 CxC4 like cysteine cluster associated with KDZ transposases HMG_box PF00505.19 EMC78119.1 - 3.5e-11 43.3 0.5 8.4e-11 42.1 0.5 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box Zn_Tnp_IS91 PF14319.6 EMC78119.1 - 3.2 7.8 5.4 6.4 6.9 0.6 3.3 3 0 0 3 3 3 0 Transposase zinc-binding domain 7tm_1 PF00001.21 EMC78121.1 - 3.9e-54 183.7 20.6 4.7e-54 183.5 20.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC78121.1 - 1.6e-11 44.1 19.2 2.2e-11 43.6 19.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC78121.1 - 8.7e-07 29.0 16.5 1.4e-06 28.3 16.5 1.3 1 1 0 1 1 1 1 Olfactory receptor Cyclin_N PF00134.23 EMC78121.1 - 0.12 12.2 0.8 0.36 10.6 0.1 2.0 2 0 0 2 2 2 0 Cyclin, N-terminal domain zf-C3HC4 PF00097.25 EMC78122.1 - 2.8e-08 33.5 7.5 3.3e-08 33.3 7.5 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMC78122.1 - 3.2e-08 33.6 6.6 3.9e-08 33.3 6.6 1.1 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EMC78122.1 - 1.1e-07 31.7 7.0 1.4e-07 31.4 7.0 1.2 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EMC78122.1 - 4.9e-07 29.5 9.2 6.1e-07 29.2 9.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EMC78122.1 - 1e-05 25.3 3.4 1.2e-05 25.0 3.4 1.1 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_3 PF13920.6 EMC78122.1 - 1.1e-05 25.1 6.5 1.2e-05 25.1 6.5 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.5 EMC78122.1 - 3.5e-05 23.8 4.9 4.4e-05 23.5 4.9 1.1 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_2 PF13639.6 EMC78122.1 - 0.00019 21.7 8.7 0.00024 21.4 8.7 1.1 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EMC78122.1 - 0.00033 20.6 7.9 0.0004 20.3 7.9 1.1 1 0 0 1 1 1 1 zinc-RING finger domain zf-Nse PF11789.8 EMC78122.1 - 0.0046 16.8 0.9 0.0056 16.5 0.9 1.1 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SPRY PF00622.28 EMC78123.1 - 1.4e-17 63.9 0.1 1.8e-17 63.6 0.1 1.1 1 0 0 1 1 1 1 SPRY domain PRY PF13765.6 EMC78123.1 - 9.1e-09 34.8 0.3 1.7e-08 33.9 0.3 1.5 1 0 0 1 1 1 1 SPRY-associated domain Pkinase_Tyr PF07714.17 EMC78124.1 - 1.2e-109 365.6 0.0 1.9e-109 364.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.6 EMC78124.1 - 1.8e-54 182.2 15.1 9.2e-12 45.4 0.0 7.3 6 1 0 6 6 6 6 Immunoglobulin domain I-set PF07679.16 EMC78124.1 - 2.5e-43 146.1 10.9 1.5e-14 53.8 0.1 7.7 6 1 2 8 8 8 4 Immunoglobulin I-set domain Pkinase PF00069.25 EMC78124.1 - 3.7e-43 147.8 0.0 3e-30 105.5 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain Ig_2 PF13895.6 EMC78124.1 - 1.6e-37 127.7 18.4 6.4e-10 39.2 0.1 9.2 8 2 0 8 8 8 6 Immunoglobulin domain ig PF00047.25 EMC78124.1 - 1.7e-26 92.2 11.4 1.6e-07 31.4 0.1 7.3 6 1 0 6 6 6 4 Immunoglobulin domain V-set PF07686.17 EMC78124.1 - 9.8e-21 74.0 16.3 0.0002 21.5 0.2 7.9 6 3 1 7 7 7 5 Immunoglobulin V-set domain VEGFR-2_TMD PF17988.1 EMC78124.1 - 7.8e-20 70.0 3.7 1.4e-19 69.2 3.7 1.5 1 0 0 1 1 1 1 VEGFR-2 Transmembrane domain C1-set PF07654.15 EMC78124.1 - 4.9e-07 30.0 0.8 0.002 18.4 0.1 4.9 5 0 0 5 5 4 1 Immunoglobulin C1-set domain Ig_5 PF16681.5 EMC78124.1 - 2.9e-06 27.6 10.8 0.68 10.4 0.0 7.0 7 1 1 8 8 7 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 EMC78124.1 - 3e-06 27.2 9.9 2.1 8.4 0.1 6.7 6 3 0 6 6 6 2 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 EMC78124.1 - 2.7e-05 23.6 1.8 13 5.5 0.0 5.6 6 0 0 6 6 6 0 Immunoglobulin domain Ig_4 PF16680.5 EMC78124.1 - 4.8e-05 23.5 10.0 4.3 7.7 0.1 6.1 6 0 0 6 6 6 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 EMC78124.1 - 7.8e-05 22.7 3.5 1.3 9.1 0.0 4.6 5 0 0 5 5 5 1 CD80-like C2-set immunoglobulin domain Receptor_2B4 PF11465.8 EMC78124.1 - 0.00076 19.7 1.3 0.053 13.7 0.1 3.6 4 0 0 4 4 4 1 Natural killer cell receptor 2B4 Haspin_kinase PF12330.8 EMC78124.1 - 0.03 13.3 0.1 0.055 12.4 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Herpes_gE PF02480.16 EMC78124.1 - 0.031 13.0 0.0 2 7.1 0.0 2.8 3 0 0 3 3 3 0 Alphaherpesvirus glycoprotein E C2-set PF05790.15 EMC78124.1 - 0.43 10.8 1.9 2 8.6 0.0 3.2 3 0 0 3 3 3 0 Immunoglobulin C2-set domain Adeno_E3_CR1 PF02440.15 EMC78124.1 - 2.2 8.1 6.0 5 7.0 0.1 3.7 4 1 0 4 4 4 0 Adenovirus E3 region protein CR1 zf-RING_2 PF13639.6 EMC78126.1 - 8.7e-12 45.2 12.1 1.5e-11 44.4 12.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EMC78126.1 - 1.8e-09 37.1 4.9 3.7e-09 36.2 4.9 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EMC78126.1 - 2.4e-08 33.7 12.3 4.3e-08 32.9 12.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC78126.1 - 2.2e-07 30.6 10.9 3.8e-07 29.9 10.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PA PF02225.22 EMC78126.1 - 3.5e-07 30.1 0.0 6e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 PA domain zf-rbx1 PF12678.7 EMC78126.1 - 5.9e-07 29.7 10.0 1.2e-06 28.7 10.0 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EMC78126.1 - 1.3e-06 28.3 9.9 2.1e-06 27.6 9.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC78126.1 - 3.4e-05 23.6 9.1 6.1e-05 22.8 9.1 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EMC78126.1 - 3.8e-05 23.6 7.4 6.9e-05 22.8 7.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EMC78126.1 - 0.00014 21.6 8.3 0.00022 21.0 8.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EMC78126.1 - 0.015 15.4 5.4 0.03 14.4 5.4 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger PspB PF06667.12 EMC78126.1 - 0.044 13.8 0.2 0.1 12.7 0.0 1.7 2 0 0 2 2 1 0 Phage shock protein B AbrB PF05145.12 EMC78126.1 - 0.069 12.1 0.2 0.1 11.5 0.2 1.2 1 0 0 1 1 1 0 Transition state regulatory protein AbrB Zn_ribbon_17 PF17120.5 EMC78126.1 - 0.078 12.6 9.9 0.23 11.1 10.0 1.7 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type Vps39_2 PF10367.9 EMC78126.1 - 0.21 12.0 0.1 0.21 12.0 0.1 2.6 3 1 1 4 4 4 0 Vacuolar sorting protein 39 domain 2 zinc_ribbon_16 PF17034.5 EMC78126.1 - 0.99 9.6 7.1 0.81 9.9 4.6 1.9 1 1 1 2 2 2 0 Zinc-ribbon like family zf-C3H2C3 PF17122.5 EMC78126.1 - 1.3 9.1 7.3 2.7 8.1 7.3 1.5 1 0 0 1 1 1 0 Zinc-finger PHD PF00628.29 EMC78126.1 - 1.9 8.5 10.6 3.2 7.7 10.6 1.4 1 0 0 1 1 1 0 PHD-finger Zf_RING PF16744.5 EMC78126.1 - 2.1 8.5 5.7 5.1 7.3 5.7 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger Prok-RING_1 PF14446.6 EMC78126.1 - 9.5 6.2 10.9 4.1 7.4 5.8 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 RabGAP-TBC PF00566.18 EMC78127.1 - 9.1e-48 162.7 2.1 1.4e-47 162.1 0.1 2.4 2 0 0 2 2 2 1 Rab-GTPase-TBC domain GRAM PF02893.20 EMC78127.1 - 8.9e-43 144.8 0.6 2.2e-23 82.3 0.1 2.6 2 0 0 2 2 2 2 GRAM domain EF-hand_1 PF00036.32 EMC78127.1 - 0.0018 17.7 1.2 0.0036 16.8 0.1 2.1 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 EMC78127.1 - 0.046 13.7 0.0 0.2 11.7 0.0 2.0 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.6 EMC78127.1 - 0.11 12.9 0.0 0.48 10.9 0.0 2.2 1 0 0 1 1 1 0 EF-hand domain pair BUD22 PF09073.10 EMC78127.1 - 0.48 9.7 9.2 0.83 8.9 9.2 1.3 1 0 0 1 1 1 0 BUD22 MRNIP PF15749.5 EMC78128.1 - 8.2e-09 36.2 0.2 8.2e-09 36.2 0.2 2.6 2 1 0 2 2 2 1 MRN-interacting protein UBA_5 PF16577.5 EMC78129.1 - 1.4e-40 137.2 0.1 2.5e-40 136.5 0.1 1.4 1 0 0 1 1 1 1 UBA domain ZZ PF00569.17 EMC78129.1 - 1e-12 47.6 3.5 1.8e-12 46.9 3.5 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type PB1 PF00564.24 EMC78129.1 - 0.018 14.9 0.0 0.033 14.1 0.0 1.4 1 0 0 1 1 1 0 PB1 domain C1_2 PF03107.16 EMC78129.1 - 0.025 14.9 2.9 0.051 13.9 2.9 1.5 1 0 0 1 1 1 0 C1 domain MAPEG PF01124.18 EMC78130.1 - 0.045 13.7 12.6 0.39 10.6 0.1 2.8 2 1 1 3 3 3 0 MAPEG family PA26 PF04636.13 EMC78131.1 - 4.6 6.1 9.4 0.32 9.9 2.1 2.1 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) Calreticulin PF00262.18 EMC78132.1 - 3.3e-167 555.9 14.9 6.3e-167 555.0 14.9 1.4 1 0 0 1 1 1 1 Calreticulin family SpoIIIAH PF12685.7 EMC78132.1 - 0.0026 17.6 1.4 0.0049 16.7 1.4 1.4 1 0 0 1 1 1 1 SpoIIIAH-like protein Connexin PF00029.19 EMC78132.1 - 0.0051 16.6 1.4 0.015 15.0 1.4 1.8 1 1 0 1 1 1 1 Connexin V_ATPase_I PF01496.19 EMC78132.1 - 0.0091 14.0 0.3 0.013 13.5 0.3 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family MAP17 PF15807.5 EMC78132.1 - 0.018 15.3 0.6 0.04 14.2 0.6 1.6 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 SID-1_RNA_chan PF13965.6 EMC78132.1 - 0.19 10.1 0.0 0.27 9.6 0.0 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 OATP PF03137.20 EMC78132.1 - 0.19 10.0 0.0 0.27 9.4 0.0 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Astro_capsid_p PF12226.8 EMC78132.1 - 1.6 7.8 7.8 4.4 6.4 7.8 1.7 1 0 0 1 1 1 0 Turkey astrovirus capsid protein TRAP_alpha PF03896.16 EMC78132.1 - 5 6.2 16.3 56 2.8 13.9 3.2 2 1 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit MAPEG PF01124.18 EMC78133.1 - 1.1e-15 57.7 5.1 1.1e-15 57.7 4.4 1.3 1 1 0 1 1 1 1 MAPEG family dNK PF01712.19 EMC78134.1 - 8.5e-65 218.4 2.8 9.5e-65 218.3 2.8 1.0 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.6 EMC78134.1 - 8.6e-05 23.1 0.1 0.00065 20.3 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EMC78134.1 - 0.0015 18.7 0.0 0.0081 16.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EMC78134.1 - 0.0087 15.8 0.0 0.051 13.3 0.1 2.1 2 0 0 2 2 2 1 Thymidylate kinase RUN PF02759.19 EMC78135.1 - 4.1e-30 104.5 0.0 4.1e-30 104.5 0.0 2.6 3 1 0 3 3 3 1 RUN domain FYVE PF01363.21 EMC78135.1 - 7.5e-20 70.8 10.3 7.5e-20 70.8 10.3 2.4 2 0 0 2 2 2 1 FYVE zinc finger YabA PF06156.13 EMC78135.1 - 0.0061 17.2 6.6 0.0061 17.2 6.6 5.6 1 1 4 5 5 5 2 Initiation control protein YabA zf-RING_5 PF14634.6 EMC78135.1 - 0.071 13.1 14.7 0.2 11.6 14.7 1.9 1 0 0 1 1 1 0 zinc-RING finger domain ADK_lid PF05191.14 EMC78135.1 - 0.92 9.5 6.4 2.8 8.0 6.4 1.8 1 0 0 1 1 1 0 Adenylate kinase, active site lid Pep_M12B_propep PF01562.19 EMC78136.1 - 3e-33 115.0 0.0 6.9e-33 113.8 0.0 1.6 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_spacer1 PF05986.14 EMC78136.1 - 1.5e-25 89.5 0.0 2.7e-25 88.6 0.0 1.5 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 EMC78136.1 - 7e-22 77.4 60.9 3.7e-10 39.8 6.9 5.8 6 0 0 6 6 6 4 Thrombospondin type 1 domain Reprolysin PF01421.19 EMC78136.1 - 2.6e-18 66.6 0.0 5.1e-18 65.7 0.0 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR_2 PF17771.1 EMC78136.1 - 7.9e-18 64.7 16.8 2e-17 63.5 5.9 5.8 6 1 1 7 7 4 2 ADAM cysteine-rich domain Reprolysin_5 PF13688.6 EMC78136.1 - 3.6e-14 53.4 0.1 7.4e-14 52.3 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EMC78136.1 - 1.3e-10 41.8 0.1 2.6e-10 40.9 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EMC78136.1 - 1.6e-09 37.9 0.2 3.7e-09 36.8 0.2 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EMC78136.1 - 2.9e-06 27.1 0.1 5.5e-06 26.2 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 EMC78136.1 - 0.0013 18.6 0.2 0.0032 17.3 0.1 1.7 2 0 0 2 2 2 1 Matrixin PLAC PF08686.11 EMC78136.1 - 0.013 16.2 7.8 0.013 16.2 7.8 3.6 4 0 0 4 4 3 0 PLAC (protease and lacunin) domain DUF4953 PF16313.5 EMC78136.1 - 0.097 11.9 0.3 0.17 11.1 0.3 1.2 1 0 0 1 1 1 0 Met-zincin DEPP PF15343.6 EMC78137.1 - 0.005 16.9 0.2 0.014 15.5 0.0 1.8 2 0 0 2 2 2 1 Decidual protein induced by progesterone family Exo_endo_phos PF03372.23 EMC78138.1 - 7.7e-21 74.7 0.0 3.2e-20 72.7 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_8 PF13855.6 EMC78138.1 - 2.6e-11 43.1 11.4 6.7e-11 41.8 7.9 2.5 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EMC78138.1 - 1.5e-10 41.1 17.1 1.6e-07 31.5 1.2 3.2 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC78138.1 - 0.0017 18.6 15.3 6.1 7.8 0.0 5.7 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_6 PF13516.6 EMC78138.1 - 0.48 10.6 15.7 1.2 9.4 0.2 4.6 4 0 0 4 4 4 0 Leucine Rich repeat SIS PF01380.22 EMC78139.1 - 4.3e-67 224.0 0.0 1.6e-36 125.0 0.0 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 EMC78139.1 - 2.1e-16 60.4 0.0 4.9e-16 59.1 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EMC78139.1 - 1.9e-13 50.4 0.0 6.6e-13 48.6 0.0 2.0 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 EMC78139.1 - 2.4e-05 23.4 0.0 3.9e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_2 PF00310.21 EMC78139.1 - 5.8e-05 22.0 0.0 0.0001 21.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.6 EMC78139.1 - 0.07 13.1 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 SIS domain Acetyltransf_6 PF13480.7 EMC78139.1 - 0.16 12.1 0.0 0.56 10.4 0.0 1.9 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Pkinase PF00069.25 EMC78140.1 - 5.7e-64 216.0 0.0 7.1e-64 215.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC78140.1 - 1.5e-29 103.1 0.1 2e-29 102.6 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMC78140.1 - 1.8e-06 27.5 0.3 2.9e-06 26.8 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EMC78140.1 - 4.7e-05 22.8 0.1 0.001 18.5 0.0 2.2 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EMC78140.1 - 0.00049 20.1 0.3 0.00091 19.2 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EMC78140.1 - 0.00054 19.6 0.2 0.00093 18.8 0.2 1.3 1 0 0 1 1 1 1 RIO1 family FTA2 PF13095.6 EMC78140.1 - 0.071 12.7 0.3 0.19 11.3 0.0 1.9 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 ATG16 PF08614.11 EMC78141.1 - 0.0058 16.9 10.1 0.0073 16.5 10.1 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Tropomyosin_1 PF12718.7 EMC78141.1 - 0.012 15.7 8.8 0.022 14.9 8.8 1.3 1 0 0 1 1 1 0 Tropomyosin like Uso1_p115_C PF04871.13 EMC78141.1 - 0.028 14.8 7.0 0.055 13.8 7.0 1.5 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF4407 PF14362.6 EMC78141.1 - 0.093 12.1 5.3 0.11 11.8 5.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3435 PF11917.8 EMC78141.1 - 0.13 11.2 9.1 0.17 10.8 9.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) TSNAXIP1_N PF15739.5 EMC78141.1 - 0.18 12.2 8.1 0.36 11.2 8.1 1.5 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus Atg14 PF10186.9 EMC78141.1 - 0.26 10.3 7.7 0.4 9.7 7.7 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Tho2 PF11262.8 EMC78141.1 - 0.31 10.2 5.1 0.44 9.7 5.1 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 WDCP PF15390.6 EMC78141.1 - 0.49 8.7 2.8 0.58 8.5 2.8 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family 5_nucleotid PF05761.14 EMC78141.1 - 0.65 8.8 5.5 0.86 8.4 5.5 1.1 1 0 0 1 1 1 0 5' nucleotidase family FapA PF03961.13 EMC78141.1 - 0.66 8.5 2.2 0.67 8.5 2.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DMPK_coil PF08826.10 EMC78141.1 - 0.7 10.1 15.8 1.7 8.8 2.7 2.3 1 1 1 2 2 2 0 DMPK coiled coil domain like Ax_dynein_light PF10211.9 EMC78141.1 - 0.88 9.5 12.3 3.7 7.5 12.6 1.8 1 1 0 1 1 1 0 Axonemal dynein light chain OEP PF02321.18 EMC78141.1 - 0.97 9.2 12.6 1.4 8.7 12.6 1.1 1 0 0 1 1 1 0 Outer membrane efflux protein Fungal_TACC PF12709.7 EMC78141.1 - 1.3 9.5 7.0 0.21 12.0 2.0 1.9 1 1 1 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins Jnk-SapK_ap_N PF09744.9 EMC78141.1 - 1.7 8.8 15.1 2.6 8.3 15.1 1.4 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Borrelia_P83 PF05262.11 EMC78141.1 - 1.8 7.0 7.8 4.1 5.8 6.7 1.8 2 0 0 2 2 2 0 Borrelia P83/100 protein DivIC PF04977.15 EMC78141.1 - 8.5 6.2 11.1 0.3 10.9 2.4 2.3 1 1 1 2 2 2 0 Septum formation initiator RasGEF PF00617.19 EMC78142.1 - 1.7e-52 178.2 0.3 4e-52 177.0 0.3 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EMC78142.1 - 4.3e-07 30.1 0.1 1.4e-06 28.5 0.1 1.9 1 0 0 1 1 1 1 RasGEF N-terminal motif Pkinase PF00069.25 EMC78143.1 - 2.9e-53 180.9 0.5 3.9e-53 180.5 0.5 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC78143.1 - 1.7e-25 89.8 1.4 4e-25 88.6 0.1 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Aminotran_3 PF00202.21 EMC78144.1 - 3e-83 279.7 0.0 3.6e-83 279.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EMC78144.1 - 0.0015 17.7 0.1 0.0024 17.1 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II DUF3301 PF11743.8 EMC78144.1 - 0.15 11.8 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3301) RRM_1 PF00076.22 EMC78145.1 - 4.7e-34 116.0 0.3 1e-15 57.3 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMC78145.1 - 1.2e-17 63.8 0.5 8.8e-09 35.4 0.1 2.5 2 1 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EMC78145.1 - 4.4e-07 29.8 0.0 0.00049 20.0 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EMC78145.1 - 2.8e-05 24.1 0.1 0.1 12.7 0.1 2.4 2 0 0 2 2 2 2 RNA binding motif NID PF07292.13 EMC78145.1 - 0.0062 17.2 0.3 0.56 10.9 0.2 2.4 2 0 0 2 2 2 1 Nmi/IFP 35 domain (NID) Peptidase_M16_C PF05193.21 EMC78145.1 - 0.026 14.6 0.1 0.062 13.3 0.1 1.6 2 0 0 2 2 2 0 Peptidase M16 inactive domain FXMRP1_C_core PF12235.8 EMC78145.1 - 0.34 11.6 5.0 0.73 10.5 5.0 1.6 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal NDK PF00334.19 EMC78146.1 - 9.6e-36 122.8 0.0 1.2e-35 122.5 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Dpy-30 PF05186.13 EMC78146.1 - 2.2e-17 62.4 0.4 3.4e-17 61.8 0.4 1.3 1 0 0 1 1 1 1 Dpy-30 motif wnt PF00110.19 EMC78147.1 - 1.2e-88 297.7 25.8 1.5e-88 297.4 25.8 1.0 1 0 0 1 1 1 1 wnt family Thymosin PF01290.20 EMC78148.1 - 8e-21 73.5 10.0 8.8e-21 73.4 10.0 1.0 1 0 0 1 1 1 1 Thymosin beta-4 family DUF4522 PF15022.6 EMC78148.1 - 0.012 15.8 0.3 0.013 15.8 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4522) WH2 PF02205.20 EMC78148.1 - 0.017 15.0 0.0 0.022 14.6 0.0 1.2 1 0 0 1 1 1 0 WH2 motif PKD_channel PF08016.12 EMC78149.1 - 1.5e-137 458.8 24.0 1.5e-137 458.8 24.0 1.4 2 0 0 2 2 2 1 Polycystin cation channel Ion_trans PF00520.31 EMC78149.1 - 3.2e-23 82.2 30.4 3.2e-23 82.2 30.4 1.8 2 0 0 2 2 2 1 Ion transport protein TMEM132D_C PF15706.5 EMC78149.1 - 1.5 8.7 3.3 6.4 6.6 3.3 2.1 1 1 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term I-set PF07679.16 EMC78150.1 - 1.4e-18 66.8 0.0 2e-18 66.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC78150.1 - 2.5e-09 37.6 0.0 5e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC78150.1 - 5.6e-08 32.9 0.0 9.4e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC78150.1 - 1.8e-05 25.0 0.0 3.8e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC78150.1 - 0.00087 19.4 0.0 0.0054 16.9 0.0 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain 7tm_1 PF00001.21 EMC78151.1 - 1.4e-51 175.4 23.2 1.4e-51 175.4 23.2 1.4 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC78151.1 - 4.2e-06 26.6 21.3 4.2e-06 26.6 21.3 2.4 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 EMC78151.1 - 6.4e-06 25.7 22.8 2.9e-05 23.6 22.8 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 EMC78151.1 - 0.0036 16.6 27.7 0.011 15.1 27.7 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw SecD_SecF PF02355.16 EMC78151.1 - 3.6 6.9 10.7 2 7.8 6.6 2.4 3 0 0 3 3 3 0 Protein export membrane protein Kelch_1 PF01344.25 EMC78152.1 - 9.1e-84 274.9 18.4 2.2e-16 59.2 0.6 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EMC78152.1 - 1.6e-38 129.7 3.1 7.1e-06 26.1 0.1 6.4 4 2 2 6 6 6 6 Kelch motif BACK PF07707.15 EMC78152.1 - 1.9e-36 124.3 1.0 1.9e-36 124.3 1.0 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 EMC78152.1 - 4.1e-32 110.7 0.9 8.8e-32 109.6 0.9 1.6 1 0 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.6 EMC78152.1 - 8.7e-29 99.2 14.5 6.7e-05 23.1 0.2 6.2 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.15 EMC78152.1 - 4.8e-28 96.0 6.4 7.7e-05 22.5 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 EMC78152.1 - 1.5e-22 79.3 4.9 0.00039 20.4 0.0 6.3 4 1 2 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC78152.1 - 2.3e-05 24.3 11.1 3.2 7.9 0.2 5.3 5 0 0 5 5 5 3 Kelch motif Skp1_POZ PF03931.15 EMC78152.1 - 0.0062 16.7 0.3 0.036 14.2 0.0 2.2 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain DUF3342 PF11822.8 EMC78152.1 - 0.16 12.2 0.9 0.89 9.8 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3342) PQQ_3 PF13570.6 EMC78152.1 - 2.2 8.9 12.3 15 6.2 0.1 4.8 5 0 0 5 5 5 0 PQQ-like domain SPARC_Ca_bdg PF10591.9 EMC78153.1 - 1.8e-32 112.0 0.4 3.8e-32 111.0 0.4 1.6 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Thyroglobulin_1 PF00086.18 EMC78153.1 - 1e-18 66.8 5.3 1e-18 66.8 5.3 2.5 2 0 0 2 2 2 1 Thyroglobulin type-1 repeat Kazal_2 PF07648.15 EMC78153.1 - 9.2e-12 44.9 11.7 1.2e-11 44.6 7.8 2.6 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EMC78153.1 - 1.6e-05 24.8 6.1 7.4e-05 22.7 6.1 2.2 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain MH2 PF03166.14 EMC78154.1 - 6e-76 254.8 1.4 8.4e-76 254.3 1.4 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.16 EMC78154.1 - 3.6e-42 142.8 0.3 8.2e-42 141.6 0.3 1.6 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.9 EMC78154.1 - 0.00015 21.6 0.0 0.00025 20.9 0.0 1.3 1 0 0 1 1 1 1 Interferon-regulatory factor 3 DUF4223 PF13978.6 EMC78154.1 - 0.13 12.2 0.8 0.27 11.2 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4223) Fasciclin PF02469.22 EMC78155.1 - 1e-100 332.9 6.2 1.8e-32 112.2 0.1 5.0 4 1 0 4 4 4 4 Fasciclin domain DUF5618 PF18498.1 EMC78155.1 - 0.062 13.5 0.0 26 5.0 0.0 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF5618) Fibrillin_U_N PF18193.1 EMC78155.1 - 0.37 10.9 1.8 1 9.6 1.8 1.6 1 0 0 1 1 1 0 Fibrillin 1 unique N-terminal domain Peptidase_M23 PF01551.22 EMC78156.1 - 4.6e-07 30.0 0.0 5.8e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M23 Peptidase_M23 PF01551.22 EMC78157.1 - 1.6e-11 44.3 0.0 3.3e-05 24.0 0.0 2.8 2 1 0 2 2 2 2 Peptidase family M23 F-box-like PF12937.7 EMC78158.1 - 4.4e-12 45.7 1.8 1e-11 44.5 1.1 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EMC78158.1 - 1.7e-10 40.5 1.3 1.7e-10 40.5 1.3 2.3 2 0 0 2 2 2 1 F-box domain F-box_5 PF18511.1 EMC78158.1 - 0.027 14.0 0.0 0.055 13.0 0.0 1.5 1 0 0 1 1 1 0 F-box Humanin PF15040.6 EMC78159.1 - 0.092 12.2 0.2 0.092 12.2 0.2 1.9 2 0 0 2 2 2 0 Humanin family Mito_carr PF00153.27 EMC78160.1 - 1.2e-60 201.4 2.3 5.6e-21 74.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein PdxA PF04166.12 EMC78160.1 - 0.069 12.6 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal phosphate biosynthetic protein PdxA DUF787 PF05619.11 EMC78160.1 - 0.091 11.9 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF787) IL8 PF00048.20 EMC78162.1 - 0.0017 18.4 2.1 0.0023 18.0 2.1 1.2 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Macro PF01661.21 EMC78163.1 - 1.1e-28 99.6 0.0 2.1e-28 98.7 0.0 1.4 1 0 0 1 1 1 1 Macro domain Histone_H2A_C PF16211.5 EMC78163.1 - 6.8e-18 64.1 1.5 6.8e-18 64.1 1.5 2.6 2 0 0 2 2 2 1 C-terminus of histone H2A Histone PF00125.24 EMC78163.1 - 1.5e-15 57.8 1.9 3e-14 53.5 0.0 2.2 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC78163.1 - 0.0048 17.2 0.0 0.017 15.4 0.0 2.0 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF1764 PF08576.10 EMC78163.1 - 0.014 16.3 1.7 0.033 15.1 1.7 1.6 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Clp_N PF02861.20 EMC78163.1 - 0.093 12.9 0.0 0.25 11.5 0.0 1.8 1 0 0 1 1 1 0 Clp amino terminal domain, pathogenicity island component YihI PF04220.12 EMC78163.1 - 0.12 12.1 5.5 3.1 7.5 0.0 2.3 2 0 0 2 2 2 0 Der GTPase activator (YihI) Pterin_4a PF01329.19 EMC78164.1 - 3.9e-32 110.3 0.1 4.3e-32 110.1 0.1 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase IF-2 PF11987.8 EMC78164.1 - 0.031 14.4 0.0 0.092 12.9 0.0 1.7 1 1 1 2 2 2 0 Translation-initiation factor 2 Thioredoxin PF00085.20 EMC78165.1 - 1.2e-09 38.0 0.0 1.7e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.16 EMC78165.1 - 0.057 12.4 0.0 0.066 12.1 0.0 1.1 1 0 0 1 1 1 0 Phosducin OST3_OST6 PF04756.13 EMC78165.1 - 0.1 12.0 0.2 0.15 11.4 0.2 1.4 1 1 0 1 1 1 0 OST3 / OST6 family, transporter family DUF5568 PF17724.1 EMC78166.1 - 8.4e-98 325.6 10.3 9.3e-98 325.5 10.3 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5568) CAML PF14963.6 EMC78167.1 - 5.1e-133 443.3 0.0 5.8e-133 443.1 0.0 1.0 1 0 0 1 1 1 1 Calcium signal-modulating cyclophilin ligand Sec23_trunk PF04811.15 EMC78168.1 - 9.6e-87 290.6 0.1 1.7e-86 289.8 0.1 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EMC78168.1 - 1.5e-24 85.7 0.6 3.7e-24 84.5 0.6 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EMC78168.1 - 1.3e-20 73.9 0.0 3.5e-20 72.5 0.0 1.8 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EMC78168.1 - 7.7e-15 54.7 4.5 2.2e-14 53.2 4.5 1.9 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EMC78168.1 - 3.7e-10 39.6 0.0 8.4e-10 38.4 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat Sen15 PF09631.10 EMC78168.1 - 0.039 14.3 0.0 0.13 12.6 0.0 1.8 1 0 0 1 1 1 0 Sen15 protein Arf PF00025.21 EMC78169.1 - 6.1e-63 211.4 0.0 7e-63 211.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EMC78169.1 - 7.7e-10 38.5 0.1 1.6e-07 30.8 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EMC78169.1 - 2e-09 37.1 0.0 2.6e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EMC78169.1 - 2.2e-07 31.1 0.0 4.7e-07 30.0 0.0 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMC78169.1 - 1.5e-06 27.9 0.0 1.7e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 EMC78169.1 - 3.1e-06 27.2 0.0 4.5e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC78169.1 - 0.00085 18.9 0.0 0.0091 15.6 0.0 1.9 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EMC78169.1 - 0.007 15.8 0.0 0.0097 15.3 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Metalloenzyme PF01676.18 EMC78169.1 - 0.077 12.3 0.0 1.6 8.0 0.0 2.0 1 1 1 2 2 2 0 Metalloenzyme superfamily PduV-EutP PF10662.9 EMC78169.1 - 0.21 11.3 0.0 1 9.1 0.0 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation zf-HC5HC2H_2 PF13832.6 EMC78170.1 - 9.6e-30 103.0 8.0 9.6e-30 103.0 8.0 2.9 3 0 0 3 3 3 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EMC78170.1 - 3.7e-23 81.6 8.1 3.7e-23 81.6 8.1 3.7 4 0 0 4 4 4 1 PHD-like zinc-binding domain PHD_2 PF13831.6 EMC78170.1 - 2.6e-12 46.1 7.0 2.6e-12 46.1 7.0 4.0 5 0 0 5 5 5 1 PHD-finger PHD PF00628.29 EMC78170.1 - 2.7e-10 40.0 7.8 2.7e-10 40.0 7.8 3.3 3 0 0 3 3 3 2 PHD-finger EPL1 PF10513.9 EMC78170.1 - 3.2e-07 30.9 1.4 3.2e-07 30.9 1.4 3.0 4 0 0 4 4 4 1 Enhancer of polycomb-like C1_1 PF00130.22 EMC78170.1 - 0.0051 16.7 4.1 0.0051 16.7 4.1 3.3 2 1 1 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) FerA PF08165.11 EMC78170.1 - 0.14 12.1 1.6 0.29 11.1 0.2 2.2 2 0 0 2 2 2 0 FerA (NUC095) domain C1_2 PF03107.16 EMC78170.1 - 0.86 10.0 25.0 0.084 13.2 5.0 3.4 3 0 0 3 3 3 0 C1 domain UQ_con PF00179.26 EMC78172.1 - 1.9e-46 157.2 0.1 4e-46 156.2 0.1 1.5 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EMC78172.1 - 0.00094 19.5 0.1 0.0011 19.2 0.1 1.3 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 EMC78172.1 - 0.012 15.4 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 UEV domain Metallophos PF00149.28 EMC78173.1 - 7.7e-35 121.2 0.6 1.2e-34 120.7 0.5 1.3 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 EMC78173.1 - 0.017 14.7 0.0 0.026 14.2 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain DUF5378 PF17349.2 EMC78173.1 - 0.083 12.2 0.0 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5378) Skp1_POZ PF03931.15 EMC78175.1 - 2.2e-30 104.6 0.7 4.9e-30 103.5 0.2 1.8 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain Skp1 PF01466.19 EMC78175.1 - 2.4e-30 104.4 1.6 4.7e-30 103.5 1.6 1.5 1 0 0 1 1 1 1 Skp1 family, dimerisation domain CTNNB1_binding PF08347.11 EMC78176.1 - 1.7e-40 139.4 6.5 1.7e-40 139.4 6.5 1.8 2 0 0 2 2 2 1 N-terminal CTNNB1 binding HMG_box PF00505.19 EMC78176.1 - 1.7e-22 79.6 1.1 3.4e-22 78.6 1.1 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC78176.1 - 7.9e-09 36.0 1.4 1.9e-08 34.7 1.4 1.6 1 0 0 1 1 1 1 HMG-box domain MATalpha_HMGbox PF04769.12 EMC78176.1 - 0.017 14.4 0.1 0.027 13.8 0.1 1.2 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box Porin_3 PF01459.22 EMC78177.1 - 3.3e-82 276.0 4.2 3.7e-82 275.8 4.2 1.0 1 0 0 1 1 1 1 Eukaryotic porin SusE PF14292.6 EMC78177.1 - 0.046 13.9 0.3 0.046 13.9 0.3 2.0 2 0 0 2 2 2 0 SusE outer membrane protein KCT2 PF17818.1 EMC78178.1 - 1.8e-87 292.3 1.2 2.8e-87 291.7 1.2 1.3 1 0 0 1 1 1 1 Keratinocyte-associated gene product TMEM40 PF15817.5 EMC78178.1 - 0.051 13.3 0.1 0.084 12.6 0.1 1.3 1 0 0 1 1 1 0 Transmembrane protein 40 family Ig_3 PF13927.6 EMC78179.1 - 2.4e-28 98.6 0.1 4.3e-17 62.5 0.0 3.7 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 EMC78179.1 - 1.1e-25 89.5 0.0 1.4e-15 57.2 0.0 3.6 4 0 0 4 4 3 2 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC78179.1 - 2.1e-15 56.8 0.0 1.7e-08 34.6 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 EMC78179.1 - 8.2e-14 51.5 0.0 1.8e-06 28.0 0.0 3.8 3 1 0 3 3 3 2 Immunoglobulin domain Kazal_2 PF07648.15 EMC78179.1 - 2.5e-09 37.1 5.1 6.8e-09 35.7 5.1 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain EF-hand_1 PF00036.32 EMC78179.1 - 4.9e-08 32.0 0.0 0.00014 21.1 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 EMC78179.1 - 9.7e-08 31.2 0.1 0.015 14.8 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EMC78179.1 - 3.9e-07 29.5 1.1 0.0024 17.6 0.3 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 EMC78179.1 - 4.7e-06 27.0 3.1 1.1e-05 25.8 3.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair V-set PF07686.17 EMC78179.1 - 5.1e-06 26.6 2.4 0.25 11.5 0.1 4.0 3 1 0 3 3 2 2 Immunoglobulin V-set domain Ig_6 PF18452.1 EMC78179.1 - 2.5e-05 23.7 0.0 0.017 14.7 0.0 3.3 3 0 0 3 3 3 1 Immunoglobulin domain Kazal_1 PF00050.21 EMC78179.1 - 3.8e-05 23.6 9.0 9.6e-05 22.3 9.0 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain SPARC_Ca_bdg PF10591.9 EMC78179.1 - 0.0006 20.1 0.2 0.0012 19.1 0.2 1.5 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 EMC78179.1 - 0.0025 17.6 0.3 0.22 11.4 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain pair C2-set_2 PF08205.12 EMC78179.1 - 0.0033 17.5 0.0 0.55 10.3 0.0 2.7 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 EMC78179.1 - 0.0042 17.4 0.1 0.28 11.6 0.0 3.6 4 0 0 4 4 4 1 Immunoglobulin C1-set domain Dockerin_1 PF00404.18 EMC78179.1 - 0.08 13.2 0.1 0.59 10.4 0.0 2.3 2 0 0 2 2 2 0 Dockerin type I domain RasGEF PF00617.19 EMC78181.1 - 1.4e-50 171.9 0.1 3.1e-50 170.8 0.1 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EMC78181.1 - 3.1e-14 53.1 0.4 1e-12 48.2 0.4 3.0 1 1 0 1 1 1 1 RasGEF N-terminal motif RA PF00788.23 EMC78181.1 - 1.5e-12 48.0 0.0 4.2e-12 46.5 0.0 1.8 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PDZ PF00595.24 EMC78181.1 - 1.9e-11 44.1 0.0 5.7e-11 42.6 0.0 1.8 1 0 0 1 1 1 1 PDZ domain cNMP_binding PF00027.29 EMC78181.1 - 2.9e-11 43.3 0.0 1.4e-06 28.3 0.0 2.7 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain PDZ_6 PF17820.1 EMC78181.1 - 3.5e-10 39.6 0.0 8.2e-10 38.4 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC78181.1 - 9.3e-05 22.7 0.0 0.00077 19.7 0.0 2.4 2 0 0 2 2 2 1 PDZ domain FNIP_M PF14637.6 EMC78182.1 - 4.7e-89 298.3 0.0 8.7e-89 297.4 0.0 1.4 1 0 0 1 1 1 1 Folliculin-interacting protein middle domain FNIP_C PF14638.6 EMC78182.1 - 9.7e-73 243.9 0.1 2.2e-72 242.7 0.1 1.7 1 0 0 1 1 1 1 Folliculin-interacting protein C-terminus FNIP_N PF14636.6 EMC78182.1 - 3.4e-25 89.8 11.5 7.1e-25 88.8 2.2 3.7 3 1 0 3 3 3 1 Folliculin-interacting protein N-terminus AMP-binding PF00501.28 EMC78184.1 - 4.9e-109 364.7 0.0 6.7e-109 364.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMC78184.1 - 6.9e-05 23.8 0.0 0.0002 22.3 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF347 PF03988.12 EMC78184.1 - 0.2 11.9 0.2 0.88 9.8 0.2 2.0 2 0 0 2 2 2 0 Repeat of Unknown Function (DUF347) P4Ha_N PF08336.11 EMC78185.1 - 4.8e-40 136.7 0.2 4.8e-40 136.7 0.2 2.0 2 0 0 2 2 2 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 2OG-FeII_Oxy_3 PF13640.6 EMC78185.1 - 8.2e-16 58.7 0.0 2e-15 57.4 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 EMC78185.1 - 6.5e-06 26.6 0.0 1.7e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF4749 PF15936.5 EMC78186.1 - 1.1e-20 74.6 0.1 2.2e-20 73.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) PDZ PF00595.24 EMC78186.1 - 2.4e-18 66.3 0.0 4.8e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain LIM PF00412.22 EMC78186.1 - 2e-14 53.5 4.2 3.7e-14 52.7 4.2 1.4 1 0 0 1 1 1 1 LIM domain PDZ_6 PF17820.1 EMC78186.1 - 1.3e-08 34.5 0.0 2.7e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC78186.1 - 2.7e-05 24.4 0.0 5.4e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 PDZ domain BNR_2 PF13088.6 EMC78186.1 - 0.0083 15.5 0.0 0.011 15.1 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain WRC PF08879.10 EMC78186.1 - 0.031 13.9 0.1 6.1 6.6 0.0 2.7 2 0 0 2 2 2 0 WRC zf-SNAP50_C PF12251.8 EMC78186.1 - 0.29 10.8 3.0 1.2 8.8 1.3 2.2 1 1 1 2 2 2 0 snRNA-activating protein of 50kDa MW C terminal Sugar_tr PF00083.24 EMC78187.1 - 1.3e-26 93.5 23.8 1.8e-26 93.1 23.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMC78187.1 - 1.5e-23 83.3 58.4 3.5e-21 75.5 36.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EMC78187.1 - 0.00039 19.1 4.6 0.00039 19.1 4.6 4.3 2 2 1 4 4 4 2 MFS/sugar transport protein Kazal_1 PF00050.21 EMC78188.1 - 2.1e-15 56.5 2.1 2.2e-15 56.4 2.1 1.0 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 EMC78188.1 - 7.2e-09 35.6 2.1 7.4e-09 35.6 2.1 1.0 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain IL12p40_C PF10420.9 EMC78189.1 - 1.9e-23 82.7 2.9 3e-23 82.1 1.6 2.0 2 0 0 2 2 2 1 Cytokine interleukin-12p40 C-terminus Ig_5 PF16681.5 EMC78189.1 - 0.00012 22.4 0.0 0.0014 19.0 0.0 2.4 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_3 PF13927.6 EMC78189.1 - 0.00055 20.5 4.9 0.016 15.8 0.1 3.4 3 1 0 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.6 EMC78189.1 - 0.00058 20.1 1.4 0.0091 16.3 0.0 3.0 1 1 2 3 3 3 1 Immunoglobulin domain Ig_4 PF16680.5 EMC78189.1 - 0.0034 17.6 0.2 0.31 11.3 0.0 2.8 2 1 1 3 3 3 1 T-cell surface glycoprotein CD3 delta chain V-set PF07686.17 EMC78189.1 - 0.015 15.4 1.0 1.3 9.3 0.2 3.0 2 1 1 3 3 3 0 Immunoglobulin V-set domain 7tm_1 PF00001.21 EMC78190.1 - 4.6e-81 272.0 7.2 6e-81 271.6 7.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC78190.1 - 7.4e-16 58.3 4.5 1.7e-15 57.1 4.5 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC78190.1 - 1.7e-05 24.7 11.4 1.9e-05 24.6 4.5 2.7 3 0 0 3 3 3 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC78190.1 - 2.6e-05 24.0 10.7 2.6e-05 24.0 10.7 2.0 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Shisa PF13908.6 EMC78190.1 - 0.062 13.5 0.1 6.3 7.0 0.1 2.4 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator DUF1980 PF09323.10 EMC78190.1 - 0.24 11.3 0.0 0.24 11.3 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) TraL PF07178.11 EMC78190.1 - 4 8.0 7.4 4.9 7.7 0.2 3.3 3 0 0 3 3 3 0 TraL protein TPR_1 PF00515.28 EMC78191.1 - 1.4e-24 84.8 3.3 6.7e-07 28.9 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EMC78191.1 - 9e-18 62.9 3.6 4.9e-05 23.1 0.2 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EMC78191.1 - 1.7e-12 46.8 5.5 0.00035 20.2 0.2 3.4 2 1 1 3 3 3 3 TPR repeat TPR_8 PF13181.6 EMC78191.1 - 2.7e-11 42.7 6.5 0.0018 18.3 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 EMC78191.1 - 2e-09 37.6 2.8 0.00026 21.2 1.7 2.5 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMC78191.1 - 1.6e-07 31.6 2.8 0.0017 19.0 0.7 3.4 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMC78191.1 - 2.1e-07 31.4 5.3 4.9e-06 27.0 1.5 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 EMC78191.1 - 3.1e-07 30.4 2.5 2e-06 27.9 1.7 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_15 PF13429.6 EMC78191.1 - 5.8e-07 29.0 2.9 0.0019 17.5 0.3 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMC78191.1 - 8.2e-06 26.4 0.9 0.0037 17.9 1.4 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EMC78191.1 - 1.8e-05 24.5 1.0 0.056 13.5 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 EMC78191.1 - 0.00019 21.6 3.3 0.0041 17.4 0.1 4.0 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMC78191.1 - 0.00075 20.0 3.7 0.0051 17.4 0.3 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF3856 PF12968.7 EMC78191.1 - 0.005 16.9 0.6 0.89 9.6 0.6 3.1 1 1 0 1 1 1 1 Domain of Unknown Function (DUF3856) TPR_10 PF13374.6 EMC78191.1 - 0.018 14.9 2.6 10 6.2 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMC78191.1 - 0.023 14.7 2.0 1.4 9.1 0.1 3.1 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TniQ PF06527.11 EMC78191.1 - 0.14 12.9 0.8 0.26 12.0 0.4 1.7 1 1 1 2 2 2 0 TniQ DUF3870 PF12986.7 EMC78191.1 - 0.16 12.2 0.0 0.45 10.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3870) RPN7 PF10602.9 EMC78191.1 - 0.35 10.6 8.6 0.032 13.9 1.3 2.4 3 0 0 3 3 3 0 26S proteasome subunit RPN7 NYD-SP28_assoc PF14775.6 EMC78191.1 - 0.67 10.1 5.0 6.6 6.9 1.9 2.8 1 1 1 2 2 2 0 Sperm tail C-terminal domain PWWP PF00855.17 EMC78192.1 - 4.3e-12 46.3 0.0 4.3e-12 46.3 0.0 3.1 2 1 0 2 2 2 1 PWWP domain Lipocalin_7 PF14651.6 EMC78193.1 - 1e-59 200.1 1.1 1.1e-59 199.9 1.1 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Cyclin_N PF00134.23 EMC78194.1 - 1.5e-20 73.2 1.9 1.5e-20 73.2 1.9 2.5 2 1 1 3 3 3 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EMC78194.1 - 7.3e-20 71.2 1.9 7.3e-20 71.2 1.9 2.2 2 0 0 2 2 2 1 Cyclin, C-terminal domain Methuselah_N PF06652.12 EMC78194.1 - 0.003 17.5 0.9 0.0056 16.6 0.9 1.4 1 0 0 1 1 1 1 Methuselah N-terminus C1q PF00386.21 EMC78195.1 - 1.5e-38 131.8 0.0 1.9e-38 131.6 0.0 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 EMC78195.1 - 1.6e-17 63.0 59.0 3.4e-09 36.3 35.2 2.3 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) BclA_C PF18573.1 EMC78195.1 - 0.0053 16.7 0.0 0.0074 16.2 0.0 1.2 1 0 0 1 1 1 1 BclA C-terminal domain Securin PF04856.13 EMC78196.1 - 8.3e-09 35.8 0.4 1.3e-08 35.2 0.4 1.3 1 1 0 1 1 1 1 Securin sister-chromatid separation inhibitor PhoLip_ATPase_C PF16212.5 EMC78197.1 - 1.7e-79 267.1 24.6 1.7e-79 267.1 24.6 1.8 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EMC78197.1 - 2e-22 78.6 1.9 1e-21 76.4 1.9 2.3 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EMC78197.1 - 4.7e-12 46.6 0.1 5.1e-06 26.9 0.1 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EMC78197.1 - 3.2e-09 36.7 0.0 2.8e-08 33.7 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EMC78197.1 - 0.00015 21.3 0.0 0.00044 19.8 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EMC78197.1 - 0.006 16.4 2.7 0.012 15.3 0.2 2.6 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Neur_chan_LBD PF02931.23 EMC78198.1 - 1.5e-50 171.7 0.0 1.9e-50 171.3 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC78198.1 - 3.6e-39 135.2 4.1 9.3e-35 120.8 2.5 2.2 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Cyclin_N PF00134.23 EMC78198.1 - 0.035 13.9 0.4 0.063 13.0 0.4 1.4 1 0 0 1 1 1 0 Cyclin, N-terminal domain DUF4396 PF14342.6 EMC78198.1 - 0.24 11.8 10.0 0.094 13.1 4.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4396) PRIMA1 PF16101.5 EMC78198.1 - 0.68 10.0 5.0 1.4 9.0 5.0 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Neur_chan_LBD PF02931.23 EMC78199.1 - 6.9e-51 172.7 0.0 9.1e-51 172.4 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC78199.1 - 1.9e-38 132.9 4.3 4.8e-31 108.6 4.9 2.2 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 EMC78200.1 - 5.6e-52 176.3 0.5 8.3e-52 175.8 0.5 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC78200.1 - 7e-41 140.8 6.4 5.3e-38 131.4 1.1 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Cyclin_N PF00134.23 EMC78201.1 - 6.8e-22 77.6 0.2 1.5e-21 76.4 0.2 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain HMMR_N PF15905.5 EMC78202.1 - 5.9e-96 321.9 65.6 5.9e-96 321.9 65.6 4.3 2 1 2 4 4 4 1 Hyaluronan mediated motility receptor N-terminal HMMR_C PF15908.5 EMC78202.1 - 1.1e-58 197.9 16.8 1.1e-58 197.9 16.8 6.0 2 1 2 5 5 5 1 Hyaluronan mediated motility receptor C-terminal DUF4936 PF16290.5 EMC78202.1 - 9.2 7.0 18.1 0.22 12.2 1.0 4.9 3 3 2 5 5 5 0 Domain of unknown function (DUF4936) RmlD_sub_bind PF04321.17 EMC78203.1 - 4.7e-84 281.9 0.0 5.4e-84 281.7 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 EMC78203.1 - 8.5e-22 77.8 0.0 1.1e-21 77.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EMC78203.1 - 1.2e-09 37.7 0.1 7.9e-07 28.5 0.1 2.7 1 1 1 2 2 2 2 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EMC78203.1 - 6.7e-09 35.6 0.0 1.7e-08 34.3 0.0 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EMC78203.1 - 3.8e-06 26.3 0.2 0.00095 18.4 0.0 2.8 1 1 1 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 EMC78203.1 - 0.00033 19.7 0.1 0.0031 16.6 0.1 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 EMC78203.1 - 0.035 13.6 0.0 0.53 9.7 0.0 2.1 2 0 0 2 2 2 0 short chain dehydrogenase Ten_N PF06484.12 EMC78204.1 - 8.9e-26 91.6 1.5 1e-25 91.4 1.5 1.0 1 0 0 1 1 1 1 Teneurin Intracellular Region Ten_N PF06484.12 EMC78205.1 - 2.6e-81 274.4 22.2 3.8e-81 273.9 22.2 1.3 1 0 0 1 1 1 1 Teneurin Intracellular Region Tox-GHH PF15636.6 EMC78205.1 - 4.1e-31 106.8 0.5 7.4e-31 106.0 0.5 1.5 1 0 0 1 1 1 1 GHH signature containing HNH/Endo VII superfamily nuclease toxin EGF_2 PF07974.13 EMC78205.1 - 2.1e-17 63.2 169.3 0.00047 20.5 13.3 10.0 10 0 0 10 10 10 8 EGF-like domain RHS_repeat PF05593.14 EMC78205.1 - 1.4e-13 51.0 33.5 0.00089 19.7 2.2 10.1 9 1 2 11 11 11 4 RHS Repeat NHL PF01436.21 EMC78205.1 - 7.1e-07 29.0 4.2 0.0097 15.9 0.0 5.6 6 0 0 6 6 6 1 NHL repeat CarboxypepD_reg PF13620.6 EMC78205.1 - 0.00016 21.9 0.2 0.00075 19.7 0.1 2.3 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain DUF5640 PF18692.1 EMC78205.1 - 0.15 12.1 1.8 3.2 7.8 0.1 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF5640) DUF2283 PF10049.9 EMC78205.1 - 2.2 8.5 4.9 23 5.3 0.0 4.1 5 0 0 5 5 5 0 Protein of unknown function (DUF2283) tRNA-synt_1d PF00750.19 EMC78206.1 - 2e-156 520.3 0.0 2.6e-156 519.9 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (R) Arg_tRNA_synt_N PF03485.16 EMC78206.1 - 6.9e-23 81.0 0.6 2e-22 79.5 0.2 2.1 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain DALR_1 PF05746.15 EMC78206.1 - 2.3e-20 73.0 1.0 4.4e-20 72.0 0.2 2.0 2 0 0 2 2 2 1 DALR anticodon binding domain tRNA-synt_1e PF01406.19 EMC78206.1 - 0.0078 15.6 0.2 0.044 13.1 0.0 2.2 3 0 0 3 3 3 1 tRNA synthetases class I (C) catalytic domain Cnn_1N PF07989.11 EMC78206.1 - 0.023 14.8 0.7 0.098 12.8 0.7 2.0 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 Homeodomain PF00046.29 EMC78207.1 - 8.4e-22 76.8 5.2 9.1e-22 76.7 5.2 1.0 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 EMC78207.1 - 8.6e-05 21.9 0.1 9.4e-05 21.8 0.1 1.1 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.11 EMC78207.1 - 0.0018 18.1 0.5 0.0042 17.0 0.4 1.6 2 0 0 2 2 2 1 Homeobox KN domain YdaS_antitoxin PF15943.5 EMC78207.1 - 0.065 13.1 0.1 0.093 12.6 0.1 1.3 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Ribosomal_S7e PF01251.18 EMC78207.1 - 0.069 12.9 0.4 0.073 12.8 0.4 1.0 1 0 0 1 1 1 0 Ribosomal protein S7e Pilt PF15453.6 EMC78207.1 - 0.093 12.1 0.2 0.1 12.0 0.2 1.0 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions I-set PF07679.16 EMC78209.1 - 2.1e-14 53.3 0.0 3.4e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC78209.1 - 2.7e-14 53.5 0.0 5.7e-14 52.5 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC78209.1 - 4.3e-07 30.0 0.0 1e-06 28.8 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain IGFBP PF00219.18 EMC78209.1 - 1.9e-06 28.4 21.1 1.9e-06 28.4 21.1 2.3 2 0 0 2 2 2 1 Insulin-like growth factor binding protein Kazal_1 PF00050.21 EMC78209.1 - 4.4e-06 26.6 2.2 4.4e-06 26.6 2.2 2.3 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 EMC78209.1 - 8.9e-05 22.5 3.8 8.9e-05 22.5 3.8 2.7 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Ig_2 PF13895.6 EMC78209.1 - 0.00015 22.0 0.0 0.00035 20.9 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC78209.1 - 0.00019 21.6 0.0 0.0013 18.9 0.0 2.2 1 1 0 1 1 1 1 Immunoglobulin V-set domain Neur_chan_LBD PF02931.23 EMC78210.1 - 6.9e-46 156.4 0.9 8.4e-46 156.1 0.1 1.5 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC78210.1 - 4.1e-21 76.2 10.6 3.2e-19 69.9 6.8 2.3 1 1 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region EF-hand_7 PF13499.6 EMC78211.1 - 1.1e-23 83.4 2.2 1.7e-18 66.8 0.3 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 EMC78211.1 - 5.4e-18 63.1 6.2 2.4e-07 29.8 0.2 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EMC78211.1 - 7.4e-16 56.7 5.5 0.00029 20.5 0.1 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 EMC78211.1 - 9.2e-15 54.2 4.4 0.0002 21.1 0.0 3.7 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EMC78211.1 - 2e-12 46.0 4.1 2.8e-05 23.4 0.1 3.7 4 0 0 4 4 4 2 EF hand SPARC_Ca_bdg PF10591.9 EMC78211.1 - 3.1e-06 27.5 1.2 0.00054 20.2 1.0 3.0 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EMC78211.1 - 0.0017 18.3 1.8 0.067 13.1 0.1 2.8 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EMC78211.1 - 0.0025 18.1 0.1 7.3 7.0 0.0 3.7 4 0 0 4 4 4 1 EF-hand domain EF-hand_10 PF14788.6 EMC78211.1 - 0.036 13.9 0.4 4.1 7.3 0.0 2.8 3 0 0 3 3 3 0 EF hand EF-hand_2 PF09068.11 EMC78211.1 - 0.041 14.0 0.0 1.4 9.1 0.0 2.4 2 0 0 2 2 2 0 EF hand Dockerin_1 PF00404.18 EMC78211.1 - 0.093 12.9 0.7 1.2 9.4 0.5 2.4 1 1 1 2 2 2 0 Dockerin type I domain His_kinase PF06580.13 EMC78211.1 - 0.11 12.8 0.1 0.35 11.2 0.0 1.9 1 1 1 2 2 2 0 Histidine kinase Troponin PF00992.20 EMC78211.1 - 0.13 12.5 0.1 0.4 11.0 0.1 1.8 1 1 1 2 2 2 0 Troponin Caleosin PF05042.13 EMC78211.1 - 0.33 10.9 3.6 6.2 6.7 0.1 2.9 2 1 0 2 2 2 0 Caleosin related protein CaKB PF03185.15 EMC78212.1 - 5.3e-73 244.9 0.2 6e-73 244.7 0.2 1.0 1 0 0 1 1 1 1 Calcium-activated potassium channel, beta subunit SH2 PF00017.24 EMC78213.1 - 8.5e-14 51.4 0.1 1.5e-13 50.6 0.1 1.4 1 0 0 1 1 1 1 SH2 domain SAM_2 PF07647.17 EMC78213.1 - 1.4e-11 44.3 0.0 2.3e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EMC78213.1 - 0.0026 18.2 0.0 0.0046 17.4 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SDA1 PF05285.12 EMC78213.1 - 4.8 6.5 8.0 7.6 5.8 8.0 1.3 1 0 0 1 1 1 0 SDA1 YL1 PF05764.13 EMC78213.1 - 8.3 6.5 13.1 1.9 8.6 9.4 1.7 2 0 0 2 2 2 0 YL1 nuclear protein Forkhead PF00250.18 EMC78214.1 - 1.1e-38 131.4 0.0 1.8e-38 130.7 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain DOCK_N PF16172.5 EMC78215.1 - 6.7e-106 354.4 0.0 1.7e-105 353.0 0.0 1.8 1 0 0 1 1 1 1 DOCK N-terminus DHR-2 PF06920.13 EMC78215.1 - 8.4e-94 315.1 5.2 8.4e-94 315.1 5.2 2.5 2 2 0 2 2 2 1 Dock homology region 2 DOCK-C2 PF14429.6 EMC78215.1 - 7.7e-60 202.1 0.0 4.2e-59 199.6 0.0 2.3 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins SH3_9 PF14604.6 EMC78215.1 - 8.4e-06 25.6 0.0 1.8e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC78215.1 - 9.1e-06 25.2 0.0 1.8e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC78215.1 - 0.00023 20.8 0.1 0.00046 19.8 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF1539 PF07560.11 EMC78215.1 - 0.17 12.0 4.3 0.31 11.1 1.3 3.3 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1539) FAM196 PF15265.6 EMC78216.1 - 3.8e-154 514.8 28.1 4.3e-154 514.7 28.1 1.0 1 0 0 1 1 1 1 FAM196 family DUF948 PF06103.11 EMC78217.1 - 9.7 6.5 11.8 42 4.5 0.0 4.8 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) LRR_8 PF13855.6 EMC78218.1 - 2.6e-76 251.3 46.2 3.1e-15 55.7 1.0 9.5 4 3 5 9 9 9 9 Leucine rich repeat EGF PF00008.27 EMC78218.1 - 2.4e-37 126.8 150.0 1.3e-06 28.6 5.1 12.7 13 0 0 13 13 11 9 EGF-like domain LRR_4 PF12799.7 EMC78218.1 - 4.2e-31 106.5 49.2 8.8e-05 22.8 1.6 11.0 9 1 1 11 11 11 10 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC78218.1 - 8.6e-29 100.1 7.9 3.5e-10 40.0 1.1 4.6 4 0 0 4 4 4 3 BspA type Leucine rich repeat region (6 copies) Laminin_G_2 PF02210.24 EMC78218.1 - 1.4e-25 90.3 0.1 2.2e-25 89.6 0.1 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 EMC78218.1 - 3.6e-22 79.0 0.1 5.6e-22 78.4 0.1 1.3 1 0 0 1 1 1 1 Laminin G domain LRR_9 PF14580.6 EMC78218.1 - 5.1e-17 61.9 16.3 5.1e-06 26.1 1.1 5.4 4 1 1 5 5 5 4 Leucine-rich repeat hEGF PF12661.7 EMC78218.1 - 5.4e-17 61.7 121.4 1.3e-06 28.8 4.9 13.6 13 0 0 13 13 12 8 Human growth factor-like EGF LRRNT PF01462.18 EMC78218.1 - 9.6e-15 53.8 29.4 7.4e-09 35.1 3.3 8.8 11 0 0 11 11 11 3 Leucine rich repeat N-terminal domain LRRCT PF01463.24 EMC78218.1 - 2.3e-12 46.5 8.7 0.16 12.6 0.0 6.3 5 0 0 5 5 5 4 Leucine rich repeat C-terminal domain Laminin_G_3 PF13385.6 EMC78218.1 - 0.00027 21.1 0.0 0.00049 20.3 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily LRR_1 PF00560.33 EMC78218.1 - 0.0079 16.6 35.1 4.5 8.2 0.0 13.2 11 3 0 11 11 10 1 Leucine Rich Repeat Fumble PF03630.14 EMC78219.1 - 4e-117 391.1 0.0 4.5e-117 390.9 0.0 1.0 1 0 0 1 1 1 1 Fumble PID PF00640.23 EMC78220.1 - 6.6e-27 94.2 0.0 1.6e-26 93.0 0.0 1.6 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) WW PF00397.26 EMC78220.1 - 3.8e-06 26.9 3.2 1.1e-05 25.4 3.2 1.8 1 0 0 1 1 1 1 WW domain PTB PF08416.13 EMC78220.1 - 0.00015 21.9 0.0 0.00026 21.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotyrosine-binding domain SRA1 PF07304.11 EMC78221.1 - 2.5e-46 157.1 0.2 3e-46 156.8 0.2 1.1 1 0 0 1 1 1 1 Steroid receptor RNA activator (SRA1) GUN4 PF05419.12 EMC78221.1 - 0.02 15.0 0.0 0.053 13.6 0.0 1.6 2 0 0 2 2 2 0 GUN4-like HCO3_cotransp PF00955.21 EMC78222.1 - 3.3e-219 728.9 0.9 4e-219 728.6 0.9 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 EMC78222.1 - 1e-74 251.7 0.0 3.8e-51 174.5 0.0 2.3 1 1 0 2 2 2 2 Band 3 cytoplasmic domain EGF PF00008.27 EMC78223.1 - 6.8e-06 26.3 5.0 1.2e-05 25.5 5.0 1.4 1 0 0 1 1 1 1 EGF-like domain EGF_2 PF07974.13 EMC78223.1 - 0.27 11.7 4.8 0.54 10.7 4.8 1.6 1 1 0 1 1 1 0 EGF-like domain hEGF PF12661.7 EMC78223.1 - 3.5 8.4 8.0 1.7 9.4 4.3 2.5 2 1 0 2 2 2 0 Human growth factor-like EGF Prefoldin_2 PF01920.20 EMC78224.1 - 1.6e-19 69.8 13.0 1.8e-19 69.6 13.0 1.1 1 0 0 1 1 1 1 Prefoldin subunit Phage_GP20 PF06810.11 EMC78224.1 - 0.034 13.9 7.6 0.64 9.8 0.8 2.1 2 0 0 2 2 2 0 Phage minor structural protein GP20 PEP-utilisers_N PF05524.13 EMC78224.1 - 0.14 12.3 3.2 8 6.7 0.2 2.1 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal DUF5320 PF17253.2 EMC78224.1 - 0.28 12.3 0.8 0.39 11.8 0.6 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5320) SlyX PF04102.12 EMC78224.1 - 1.9 9.1 7.0 8.1 7.1 0.6 2.4 2 0 0 2 2 2 0 SlyX XhlA PF10779.9 EMC78224.1 - 5.7 7.2 9.4 0.95 9.7 2.6 2.2 2 0 0 2 2 2 0 Haemolysin XhlA zf-CXXC PF02008.20 EMC78226.1 - 1.7e-07 31.1 23.5 2.8e-07 30.5 23.5 1.3 1 0 0 1 1 1 1 CXXC zinc finger domain QueC PF06508.13 EMC78226.1 - 3.4 7.1 11.0 2 7.9 0.8 2.3 1 1 1 2 2 2 0 Queuosine biosynthesis protein QueC UQ_con PF00179.26 EMC78227.1 - 8.5e-48 161.6 0.1 9.4e-48 161.4 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EMC78227.1 - 0.01 16.1 0.0 0.017 15.4 0.0 1.4 1 0 0 1 1 1 0 RWD domain Prok-E2_B PF14461.6 EMC78227.1 - 0.021 14.5 0.0 0.024 14.3 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B UEV PF05743.13 EMC78227.1 - 0.053 13.4 0.1 0.085 12.7 0.1 1.4 1 1 0 1 1 1 0 UEV domain TMEM173 PF15009.6 EMC78228.1 - 1.5e-80 270.5 0.6 1.7e-80 270.3 0.6 1.0 1 0 0 1 1 1 1 Transmembrane protein 173 RB_A PF01858.17 EMC78228.1 - 0.1 12.4 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 Retinoblastoma-associated protein A domain Nuc_sug_transp PF04142.15 EMC78229.1 - 6.3e-39 134.0 16.3 7.8e-39 133.7 16.3 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter Proton_antipo_N PF00662.20 EMC78229.1 - 0.19 11.8 8.0 1.2 9.3 1.6 3.7 3 0 0 3 3 3 0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus YL1_C PF08265.11 EMC78229.1 - 0.22 11.3 0.3 0.77 9.6 0.1 2.0 2 0 0 2 2 2 0 YL1 nuclear protein C-terminal domain EamA PF00892.20 EMC78229.1 - 1.1 9.5 33.4 0.051 13.7 4.8 2.5 2 1 0 2 2 2 0 EamA-like transporter family Atx10homo_assoc PF09759.9 EMC78230.1 - 0.00018 21.4 0.1 0.64 10.1 0.0 3.4 3 0 0 3 3 3 2 Spinocerebellar ataxia type 10 protein domain Arm PF00514.23 EMC78230.1 - 0.0065 16.5 17.9 0.84 9.8 0.0 6.8 6 0 0 6 6 6 2 Armadillo/beta-catenin-like repeat RED_N PF07808.13 EMC78232.1 - 1.7e-100 335.5 15.9 1.7e-100 335.5 15.9 2.3 2 0 0 2 2 2 1 RED-like protein N-terminal region RED_C PF07807.11 EMC78232.1 - 2.5e-49 166.4 7.1 2.5e-49 166.4 7.1 3.7 4 1 0 4 4 4 1 RED-like protein C-terminal region PRP38_assoc PF12871.7 EMC78232.1 - 0.004 17.7 14.0 0.004 17.7 14.0 3.7 3 0 0 3 3 3 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Lsm_interact PF05391.11 EMC78232.1 - 0.01 15.3 0.1 0.044 13.3 0.1 2.2 1 0 0 1 1 1 0 Lsm interaction motif MCR_C PF04609.12 EMC78232.1 - 0.52 9.3 3.7 0.12 11.4 0.2 1.7 2 0 0 2 2 2 0 Methyl-coenzyme M reductase operon protein C tRNA-synt_His PF13393.6 EMC78233.1 - 6e-41 140.7 0.0 7.6e-41 140.4 0.0 1.1 1 0 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 EMC78233.1 - 5.5e-11 42.5 0.5 1.5e-10 41.1 0.5 1.8 1 1 0 1 1 1 1 Anticodon binding domain HGTP_anticodon2 PF12745.7 EMC78233.1 - 9e-05 22.1 0.2 0.00014 21.5 0.2 1.2 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs tRNA-synt_2 PF00152.20 EMC78233.1 - 0.0015 17.6 0.0 0.0042 16.2 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) FAM198 PF15051.6 EMC78233.1 - 0.13 11.2 0.0 0.23 10.3 0.0 1.4 1 0 0 1 1 1 0 FAM198 protein WHEP-TRS PF00458.20 EMC78233.1 - 0.4 10.9 2.4 0.44 10.7 0.4 2.1 2 0 0 2 2 2 0 WHEP-TRS domain tRNA-synt_His PF13393.6 EMC78234.1 - 8.8e-27 94.2 0.0 6.5e-22 78.2 0.0 2.2 2 0 0 2 2 2 2 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 EMC78234.1 - 7.3e-17 61.3 0.1 1.4e-16 60.4 0.1 1.5 1 0 0 1 1 1 1 Anticodon binding domain HGTP_anticodon2 PF12745.7 EMC78234.1 - 3.3e-07 30.1 0.0 4.7e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs tRNA-synt_2 PF00152.20 EMC78234.1 - 0.14 11.2 0.0 0.32 10.0 0.0 1.7 2 0 0 2 2 2 0 tRNA synthetases class II (D, K and N) zf-C2H2_jaz PF12171.8 EMC78235.1 - 8.1e-07 29.2 1.5 8.1e-07 29.2 1.5 1.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC78235.1 - 1.6e-06 28.3 1.4 2.5e-06 27.7 1.4 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type SNRNP27 PF08648.12 EMC78235.1 - 9.9e-05 22.3 0.3 9.9e-05 22.3 0.3 2.5 4 0 0 4 4 4 1 U4/U6.U5 small nuclear ribonucleoproteins zf-U1 PF06220.12 EMC78235.1 - 0.00016 21.4 1.0 0.00027 20.6 1.0 1.4 1 0 0 1 1 1 1 U1 zinc finger Cgr1 PF03879.14 EMC78235.1 - 0.015 15.7 16.8 0.015 15.7 16.8 2.2 2 0 0 2 2 2 0 Cgr1 family DUF4250 PF14056.6 EMC78235.1 - 0.046 13.7 0.4 0.12 12.3 0.3 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4250) zf-C2H2 PF00096.26 EMC78235.1 - 0.74 10.4 3.9 0.27 11.8 1.0 1.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type Vma12 PF11712.8 EMC78235.1 - 2.6 8.1 8.1 20 5.3 5.2 2.1 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Presenilin PF01080.17 EMC78235.1 - 2.7 6.6 3.3 2.7 6.7 3.3 1.2 1 0 0 1 1 1 0 Presenilin Cadherin PF00028.17 EMC78236.1 - 8e-89 292.3 0.3 4.3e-19 68.7 0.0 6.5 6 0 0 6 6 6 6 Cadherin domain Cadherin_tail PF15974.5 EMC78236.1 - 1.9e-60 203.0 3.9 4.4e-60 201.8 3.9 1.7 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.12 EMC78236.1 - 1.2e-32 111.6 0.0 4.6e-29 100.1 0.0 4.2 6 0 0 6 6 6 2 Cadherin-like Cadherin_C_2 PF16492.5 EMC78236.1 - 1.8e-26 92.7 0.4 5.5e-26 91.1 0.1 2.1 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal RET_CLD1 PF17756.1 EMC78236.1 - 0.0066 16.7 0.0 1.4 9.2 0.0 3.4 3 0 0 3 3 3 1 RET Cadherin like domain 1 He_PIG PF05345.12 EMC78236.1 - 0.017 15.3 6.1 0.3 11.3 0.4 4.9 5 0 0 5 5 5 0 Putative Ig domain Cadherin_4 PF17803.1 EMC78236.1 - 0.052 14.2 12.7 3.3 8.4 5.8 5.5 3 1 1 4 4 4 0 Bacterial cadherin-like domain Big_9 PF17963.1 EMC78236.1 - 2.2 9.1 19.9 6.1 7.7 6.5 5.4 5 1 0 5 5 5 0 Bacterial Ig domain Cadherin PF00028.17 EMC78237.1 - 0 1349.0 7.4 4.5e-20 71.9 1.1 27.3 27 0 0 27 27 27 27 Cadherin domain Cadherin_3 PF16184.5 EMC78237.1 - 3.8e-23 81.6 56.4 0.021 14.8 0.1 18.0 18 0 0 18 18 18 7 Cadherin-like Cadherin_2 PF08266.12 EMC78237.1 - 5.1e-12 45.4 0.0 5.8 6.8 0.0 11.9 13 0 0 13 13 13 2 Cadherin-like MreC PF04085.14 EMC78237.1 - 4.2e-07 30.0 20.4 0.26 11.2 0.4 7.6 7 0 0 7 7 7 4 rod shape-determining protein MreC VWA_3_C PF18571.1 EMC78237.1 - 0.0013 18.6 16.4 1.4e+02 2.5 0.1 11.6 12 0 0 12 12 12 0 von Willebrand factor type A C-terminal domain RRF PF01765.19 EMC78237.1 - 0.003 17.5 0.8 42 4.1 0.0 4.2 4 0 0 4 4 4 0 Ribosome recycling factor NUC153 PF08159.12 EMC78237.1 - 0.021 14.6 0.0 15 5.5 0.0 3.5 3 0 0 3 3 3 0 NUC153 domain RNase_II_C_S1 PF18614.1 EMC78237.1 - 5 7.1 17.9 52 3.9 0.3 6.9 5 0 0 5 5 5 0 RNase II-type exonuclease C-terminal S1 domain DUF5049 PF16468.5 EMC78237.1 - 6.1 6.8 12.7 26 4.8 0.1 5.6 6 0 0 6 6 6 0 Domain of unknown function (DUF5049) HCV_NS5a_C PF12941.7 EMC78238.1 - 0.36 10.6 3.6 0.5 10.2 3.6 1.2 1 0 0 1 1 1 0 HCV NS5a protein C-terminal region Cadherin PF00028.17 EMC78241.1 - 0 1725.8 0.0 4.3e-19 68.7 0.0 35.0 34 1 0 34 34 34 33 Cadherin domain Cadherin_2 PF08266.12 EMC78241.1 - 4.2e-36 122.7 5.4 9.4e-08 31.8 0.8 18.6 21 0 0 21 21 21 6 Cadherin-like RET_CLD1 PF17756.1 EMC78241.1 - 4.9e-33 114.1 0.0 0.7 10.2 0.0 17.1 17 0 0 17 17 17 7 RET Cadherin like domain 1 Cadherin_3 PF16184.5 EMC78241.1 - 1.5e-24 86.1 35.5 0.04 13.9 0.0 23.5 27 0 0 27 27 27 6 Cadherin-like Cadherin_4 PF17803.1 EMC78241.1 - 2.5e-13 50.4 118.1 0.083 13.5 0.3 24.1 25 0 0 25 25 25 10 Bacterial cadherin-like domain DUF3857 PF12969.7 EMC78241.1 - 5.4e-13 49.3 7.0 0.54 10.3 0.0 6.7 6 0 0 6 6 6 5 Domain of Unknown Function with PDB structure (DUF3857) DUF4958 PF16319.5 EMC78241.1 - 7.5e-10 37.5 7.1 0.52 8.2 0.0 7.5 7 1 1 8 8 8 4 Domain of unknown function (DUF4958) DUF3313 PF11769.8 EMC78241.1 - 1.6e-08 34.6 30.4 2.9 7.7 0.2 12.1 14 1 0 14 14 14 5 Protein of unknown function (DUF3313) ChitinaseA_N PF08329.10 EMC78241.1 - 3.6e-05 23.4 0.3 2.5 7.8 0.0 5.6 6 0 0 6 6 6 1 Chitinase A, N-terminal domain DUF1214 PF06742.11 EMC78241.1 - 6.1e-05 23.4 0.4 30 5.1 0.0 8.1 9 0 0 9 9 9 0 Protein of unknown function (DUF1214) GFP PF01353.22 EMC78241.1 - 0.00047 19.7 0.0 16 4.9 0.0 5.3 5 0 0 5 5 5 0 Green fluorescent protein LRV PF01816.17 EMC78241.1 - 9.7 6.8 13.6 1.6 9.3 0.5 6.1 6 0 0 6 6 6 0 Leucine rich repeat variant Hist_deacetyl PF00850.19 EMC78242.1 - 2.2e-81 273.7 0.1 3.1e-81 273.2 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain RELT PF12606.8 EMC78243.1 - 2e-23 81.1 1.7 4e-23 80.1 1.7 1.5 1 0 0 1 1 1 1 Tumour necrosis factor receptor superfamily member 19 DUF5383 PF17355.2 EMC78243.1 - 0.012 15.9 0.2 0.11 12.9 0.0 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5383) SH3_1 PF00018.28 EMC78244.1 - 3.5e-11 42.5 0.1 7e-11 41.6 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC78244.1 - 2.3e-07 30.4 0.1 3.9e-07 29.6 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EMC78244.1 - 3.6e-07 29.9 0.1 9.3e-07 28.6 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 EMC78244.1 - 1.9e-05 24.9 0.1 3.6e-05 23.9 0.1 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain hSH3 PF14603.6 EMC78244.1 - 8.9e-05 22.9 0.0 0.00018 21.9 0.0 1.4 1 0 0 1 1 1 1 Helically-extended SH3 domain MazE_antitoxin PF04014.18 EMC78244.1 - 0.16 11.9 0.2 0.34 10.9 0.2 1.5 1 0 0 1 1 1 0 Antidote-toxin recognition MazE, bacterial antitoxin 7tm_1 PF00001.21 EMC78245.1 - 1e-37 129.9 21.2 1.9e-37 129.1 21.2 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3681 PF12442.8 EMC78245.1 - 0.098 13.1 3.4 0.56 10.7 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3681) DUF3950 PF13132.6 EMC78245.1 - 0.11 12.2 0.1 0.25 11.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3950) Pox_I5 PF04713.12 EMC78245.1 - 0.64 10.1 6.0 1.6 8.8 6.0 1.6 1 0 0 1 1 1 0 Poxvirus protein I5 RhoGAP PF00620.27 EMC78246.1 - 8e-40 136.1 0.1 1.9e-39 134.9 0.1 1.6 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 EMC78246.1 - 5.8e-27 94.3 0.3 1.4e-06 28.8 0.1 4.5 4 0 0 4 4 4 4 PH domain ArfGap PF01412.18 EMC78246.1 - 9.3e-17 61.2 0.0 3.1e-16 59.5 0.0 1.9 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf SAM_2 PF07647.17 EMC78246.1 - 3.8e-15 55.8 0.0 2.4e-14 53.2 0.1 2.3 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) RA PF00788.23 EMC78246.1 - 5.1e-12 46.3 0.0 1.3e-11 45.0 0.0 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_1 PF00536.30 EMC78246.1 - 9.4e-12 45.2 0.0 2.8e-11 43.7 0.0 1.8 2 0 0 2 2 1 1 SAM domain (Sterile alpha motif) PH_3 PF14593.6 EMC78246.1 - 0.00011 22.2 0.0 0.0012 18.9 0.0 2.6 2 0 0 2 2 2 1 PH domain PH_6 PF15406.6 EMC78246.1 - 0.00021 21.5 0.0 0.00074 19.8 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 EMC78246.1 - 0.0064 16.9 1.9 1.8 9.0 0.1 4.1 3 1 0 3 3 3 1 Pleckstrin homology domain PH_8 PF15409.6 EMC78246.1 - 0.063 13.6 0.0 0.35 11.2 0.0 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain PH_2 PF08458.10 EMC78246.1 - 0.16 12.3 0.4 0.47 10.8 0.0 2.0 2 0 0 2 2 2 0 Plant pleckstrin homology-like region START PF01852.19 EMC78247.1 - 6.3e-27 94.4 0.0 7.9e-27 94.0 0.0 1.1 1 0 0 1 1 1 1 START domain DUF3074 PF11274.8 EMC78247.1 - 4.5e-05 23.5 0.0 0.00025 21.1 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3074) Cadherin PF00028.17 EMC78248.1 - 3.1e-112 367.3 6.8 6.3e-23 81.0 0.0 7.3 7 0 0 7 7 7 7 Cadherin domain Protocadherin PF08374.11 EMC78248.1 - 4.8e-82 275.2 2.2 9.1e-82 274.2 2.2 1.5 1 0 0 1 1 1 1 Protocadherin Cadherin_2 PF08266.12 EMC78248.1 - 1.2e-13 50.7 0.0 4.7e-05 23.1 0.0 6.0 6 1 0 6 6 6 3 Cadherin-like Cadherin_3 PF16184.5 EMC78248.1 - 2.3e-07 30.8 7.8 0.74 9.8 0.1 5.9 6 0 0 6 6 6 3 Cadherin-like TMEM154 PF15102.6 EMC78248.1 - 0.013 15.4 0.0 0.032 14.1 0.0 1.7 1 0 0 1 1 1 0 TMEM154 protein family EphA2_TM PF14575.6 EMC78248.1 - 0.063 14.2 0.0 0.14 13.0 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.20 EMC78248.1 - 0.074 13.0 0.1 0.18 11.8 0.1 1.6 1 0 0 1 1 1 0 Syndecan domain Mid2 PF04478.12 EMC78248.1 - 0.08 12.8 0.1 0.32 10.8 0.0 2.0 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor FlgD_ig PF13860.6 EMC78248.1 - 0.11 12.3 1.6 1.5 8.7 0.1 3.5 3 0 0 3 3 3 0 FlgD Ig-like domain Sel1 PF08238.12 EMC78249.1 - 7.7e-22 77.3 19.0 6.2e-07 29.9 0.3 5.4 5 1 0 5 5 5 4 Sel1 repeat TPR_6 PF13174.6 EMC78249.1 - 0.0018 18.8 5.7 6.9 7.5 0.0 4.7 5 1 0 5 5 5 3 Tetratricopeptide repeat DUF5527 PF17665.1 EMC78250.1 - 1.2e-08 34.6 0.0 1.9e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5527) m04gp34like PF12216.8 EMC78250.1 - 0.16 11.5 0.1 0.2 11.2 0.1 1.1 1 0 0 1 1 1 0 Immune evasion protein ECSCR PF15820.5 EMC78251.1 - 7.5e-20 70.7 1.2 7.5e-20 70.7 1.2 1.7 2 0 0 2 2 2 1 Endothelial cell-specific chemotaxis regulator MGC-24 PF05283.11 EMC78251.1 - 0.0044 17.5 3.4 0.0044 17.5 3.4 1.8 1 1 1 2 2 2 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin ABC2_membrane_3 PF12698.7 EMC78251.1 - 0.0097 15.1 0.0 0.011 14.9 0.0 1.0 1 0 0 1 1 1 1 ABC-2 family transporter protein Orf78 PF06024.12 EMC78251.1 - 0.14 12.5 0.1 0.19 12.1 0.1 1.4 1 1 0 1 1 1 0 Orf78 (ac78) DUF3984 PF13136.6 EMC78251.1 - 0.31 10.4 4.2 0.37 10.2 4.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) EphA2_TM PF14575.6 EMC78251.1 - 0.32 11.9 3.0 0.5 11.3 1.4 1.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 EMC78251.1 - 0.32 10.9 6.2 0.79 9.6 6.2 1.8 1 1 0 1 1 1 0 TMEM154 protein family AJAP1_PANP_C PF15298.6 EMC78251.1 - 0.44 10.7 8.5 0.77 9.9 8.5 1.5 1 1 0 1 1 1 0 AJAP1/PANP C-terminus Xan_ur_permease PF00860.20 EMC78252.1 - 3.6e-85 286.0 23.1 4.5e-85 285.7 23.1 1.1 1 0 0 1 1 1 1 Permease family PAM2 PF07145.15 EMC78253.1 - 3.2e-07 29.6 0.8 3.2e-07 29.6 0.8 1.9 2 0 0 2 2 2 1 Ataxin-2 C-terminal region DUF3911 PF13050.6 EMC78253.1 - 0.019 15.1 0.2 0.034 14.2 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3911) RRM_1 PF00076.22 EMC78254.1 - 2.7e-09 36.7 0.0 0.00033 20.4 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMC78254.1 - 5.7e-07 29.2 0.2 0.0093 15.6 0.0 2.4 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTU2 PF10288.9 EMC78254.1 - 1.6 9.0 0.0 1.6 9.0 0.0 4.2 4 1 0 4 4 4 0 Cytoplasmic tRNA 2-thiolation protein 2 zf-C2H2_jaz PF12171.8 EMC78254.1 - 2.8 8.4 10.0 2.1 8.8 1.7 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Fes1 PF08609.10 EMC78255.1 - 1.8e-06 28.8 1.5 4.6e-06 27.4 1.5 1.8 1 0 0 1 1 1 1 Nucleotide exchange factor Fes1 V-ATPase_H_C PF11698.8 EMC78255.1 - 0.0037 17.4 2.0 0.035 14.2 0.1 2.8 2 1 1 3 3 3 1 V-ATPase subunit H CDC14 PF08045.11 EMC78255.1 - 0.0079 15.3 4.2 0.011 14.8 0.1 2.5 3 0 0 3 3 3 1 Cell division control protein 14, SIN component Atg14 PF10186.9 EMC78255.1 - 0.018 14.2 1.5 0.027 13.6 1.5 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 MSP7_C PF12948.7 EMC78255.1 - 0.021 15.5 2.1 0.074 13.7 2.1 1.9 2 0 0 2 2 2 0 MSP7-like protein C-terminal domain DUF4704 PF15787.5 EMC78255.1 - 0.056 12.7 1.9 0.089 12.0 0.2 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4704) BMFP PF04380.13 EMC78255.1 - 0.094 13.2 3.2 0.23 12.0 3.2 1.7 1 0 0 1 1 1 0 Membrane fusogenic activity DUF2120 PF09893.9 EMC78255.1 - 0.11 12.6 2.3 0.16 12.1 1.4 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) HEAT_EZ PF13513.6 EMC78255.1 - 0.13 12.8 0.5 0.77 10.3 0.1 2.6 3 1 0 3 3 3 0 HEAT-like repeat Vinculin PF01044.19 EMC78257.1 - 0 1038.1 37.4 4.8e-215 716.9 24.3 2.1 1 1 1 2 2 2 2 Vinculin family DUF4685 PF15737.5 EMC78257.1 - 0.17 12.3 1.7 33 4.9 0.3 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4685) Peptidase_C5 PF00770.18 EMC78257.1 - 0.19 11.4 0.0 0.43 10.2 0.0 1.5 1 0 0 1 1 1 0 Adenovirus endoprotease LRR_8 PF13855.6 EMC78258.1 - 1.3e-46 156.2 54.8 5.8e-15 54.8 7.3 5.1 2 1 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EMC78258.1 - 2.9e-23 81.6 38.9 3.6e-06 27.2 1.4 6.3 4 2 2 6 6 6 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC78258.1 - 3.8e-19 68.9 0.1 2.8e-09 37.0 0.0 3.4 2 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC78258.1 - 1.1e-11 44.6 11.1 0.00033 20.2 0.4 3.8 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 EMC78258.1 - 5.6e-07 29.2 35.2 0.98 10.2 0.2 10.0 10 1 0 10 10 10 3 Leucine Rich Repeat LRRNT PF01462.18 EMC78258.1 - 0.019 14.6 2.0 0.019 14.6 2.0 2.5 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 EMC78258.1 - 0.92 9.7 40.8 1.6 8.9 0.1 9.3 10 0 0 10 10 10 0 Leucine Rich repeat eRF1_2 PF03464.15 EMC78259.1 - 1.4e-46 158.1 0.1 2.4e-46 157.3 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EMC78259.1 - 4.4e-39 133.5 0.3 9.3e-39 132.4 0.3 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 EMC78259.1 - 2.2e-18 66.5 0.0 4.2e-18 65.6 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 EMC78259.1 - 8.9e-11 42.2 0.1 1.3e-10 41.7 0.1 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 EMC78259.1 - 7.2e-09 36.0 0.0 1.2e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 Ribosomal_L7Ae PF01248.26 EMC78259.1 - 0.011 15.5 0.0 0.021 14.5 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF4825 PF16107.5 EMC78259.1 - 0.12 12.5 0.1 4 7.6 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4825) WD40 PF00400.32 EMC78260.1 - 8.9e-37 124.5 17.4 6.1e-06 26.9 0.0 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat Beta-TrCP_D PF12125.8 EMC78260.1 - 9.9e-26 89.4 2.3 2.1e-25 88.3 2.3 1.6 1 0 0 1 1 1 1 D domain of beta-TrCP F-box-like PF12937.7 EMC78260.1 - 1.1e-09 38.0 0.1 2.6e-09 36.8 0.1 1.7 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 EMC78260.1 - 8.6e-09 35.6 2.7 0.046 14.0 0.0 4.6 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 EMC78260.1 - 1.4e-06 28.0 0.0 4.2e-06 26.5 0.0 1.8 1 0 0 1 1 1 1 F-box domain WD40_like PF17005.5 EMC78260.1 - 2.5e-05 23.8 0.1 0.047 13.0 0.2 2.2 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 EMC78260.1 - 0.062 11.9 10.5 0.21 10.2 0.1 4.4 2 1 2 5 5 5 0 Nucleoporin Nup120/160 DUF5046 PF16465.5 EMC78260.1 - 0.065 12.7 0.1 4.8 6.5 0.1 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF5046) DUF4508 PF14969.6 EMC78260.1 - 0.09 13.0 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) FGF PF00167.18 EMC78262.1 - 6.3e-33 113.5 0.1 8.3e-33 113.2 0.1 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Nudc_N PF14050.6 EMC78262.1 - 0.091 12.8 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 N-terminal conserved domain of Nudc. Nucleoplasmin PF03066.15 EMC78263.1 - 3.8e-35 120.4 0.8 5.7e-34 116.7 0.8 2.5 1 1 0 1 1 1 1 Nucleoplasmin/nucleophosmin domain NPM1-C PF16276.5 EMC78263.1 - 1.6e-28 98.4 0.9 1.6e-28 98.4 0.9 1.8 2 0 0 2 2 2 1 Nucleophosmin C-terminal domain TFIIF_alpha PF05793.12 EMC78263.1 - 2.9e-05 22.9 18.2 3e-05 22.8 18.2 1.1 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SDA1 PF05285.12 EMC78263.1 - 0.00054 19.5 14.7 0.00071 19.1 14.7 1.2 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 EMC78263.1 - 0.0027 16.0 20.4 0.0037 15.5 20.4 1.1 1 0 0 1 1 1 1 Nop14-like family MalF_P2 PF14785.6 EMC78263.1 - 0.011 15.8 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 Maltose transport system permease protein MalF P2 domain NOA36 PF06524.12 EMC78263.1 - 0.15 11.3 20.2 0.3 10.4 20.2 1.4 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 EMC78263.1 - 0.92 7.7 17.5 1.3 7.2 17.5 1.2 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 EMC78263.1 - 1.2 7.2 22.4 1.7 6.6 22.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi PI3K_1B_p101 PF10486.9 EMC78263.1 - 1.5 6.5 6.5 1.8 6.2 6.5 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit LAP1C PF05609.12 EMC78263.1 - 2.1 7.3 11.8 2.8 6.9 11.8 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) RRN3 PF05327.11 EMC78263.1 - 3.4 6.1 14.4 4.9 5.6 14.4 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Hid1 PF12722.7 EMC78263.1 - 3.8 5.5 8.6 5 5.1 8.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein YL1 PF05764.13 EMC78263.1 - 5.7 7.0 27.4 16 5.5 27.4 1.8 1 1 0 1 1 1 0 YL1 nuclear protein ComS PF17584.2 EMC78264.1 - 0.24 11.0 0.1 0.24 11.0 0.1 3.5 5 0 0 5 5 5 0 Bacillus competence protein S PTN_MK_N PF05196.13 EMC78264.1 - 4.2 7.7 21.9 16 5.8 0.6 6.3 5 0 0 5 5 5 0 PTN/MK heparin-binding protein family, N-terminal domain Defensin_beta PF00711.19 EMC78265.1 - 1.8e-07 31.1 12.8 2.3e-07 30.7 12.8 1.2 1 0 0 1 1 1 1 Beta defensin Defensin_propep PF00879.18 EMC78265.1 - 0.00019 21.6 0.3 0.00021 21.5 0.3 1.1 1 0 0 1 1 1 1 Defensin propeptide Defensin_big PF14862.6 EMC78265.1 - 0.48 10.8 5.7 1.1 9.7 5.7 1.7 1 1 0 1 1 1 0 Big defensin Defensin_beta PF00711.19 EMC78266.1 - 2.3e-08 33.9 13.3 2.7e-08 33.7 13.3 1.1 1 0 0 1 1 1 1 Beta defensin Ornatin PF02088.15 EMC78266.1 - 0.075 12.8 2.0 0.075 12.8 2.0 1.9 1 1 1 2 2 2 0 Ornatin Defensin_beta PF00711.19 EMC78267.1 - 1.3e-07 31.5 10.4 1.5e-07 31.3 10.4 1.1 1 0 0 1 1 1 1 Beta defensin Defensin_beta PF00711.19 EMC78268.1 - 7.1e-07 29.1 11.6 8.3e-07 28.9 11.6 1.1 1 0 0 1 1 1 1 Beta defensin Defensin_propep PF00879.18 EMC78268.1 - 0.065 13.5 0.2 0.075 13.3 0.2 1.1 1 0 0 1 1 1 0 Defensin propeptide Defensin_beta PF00711.19 EMC78269.1 - 1.4e-07 31.4 10.8 1.7e-07 31.1 10.8 1.1 1 0 0 1 1 1 1 Beta defensin DEFB136 PF17333.2 EMC78269.1 - 0.00052 19.9 5.2 0.00068 19.5 5.2 1.1 1 0 0 1 1 1 1 Beta defensin 136 Defensin_beta PF00711.19 EMC78270.1 - 1.4e-06 28.2 9.4 1.7e-06 27.9 9.4 1.1 1 0 0 1 1 1 1 Beta defensin Defensin_beta PF00711.19 EMC78271.1 - 3.7e-12 46.1 8.0 4.3e-12 45.8 8.0 1.1 1 0 0 1 1 1 1 Beta defensin Defensin_beta PF00711.19 EMC78272.1 - 1.1e-09 38.1 5.4 1.3e-09 37.9 5.4 1.1 1 0 0 1 1 1 1 Beta defensin Defensin_beta PF00711.19 EMC78273.1 - 4.2e-07 29.9 24.1 5.4e-05 23.1 8.4 2.5 2 1 0 2 2 2 2 Beta defensin Inhibitor_I68 PF10468.9 EMC78273.1 - 0.088 13.2 10.2 0.11 12.9 10.2 1.1 1 0 0 1 1 1 0 Carboxypeptidase inhibitor I68 Defensin_int PF17858.1 EMC78273.1 - 0.35 10.9 15.4 0.82 9.7 3.6 3.0 1 1 2 3 3 3 0 Platypus intermediate defensin-like peptide Myotoxins PF00819.17 EMC78273.1 - 0.59 10.4 24.9 0.51 10.7 6.7 2.9 2 1 0 2 2 2 0 Myotoxin, crotamine Defensin_big PF14862.6 EMC78273.1 - 8 6.9 11.9 4.6e+02 1.2 11.9 2.5 1 1 0 1 1 1 0 Big defensin Defensin_beta PF00711.19 EMC78274.1 - 1.1e-05 25.3 7.0 1.7e-05 24.7 7.0 1.3 1 0 0 1 1 1 1 Beta defensin Defensin_beta_2 PF13841.6 EMC78274.1 - 5.4e-05 23.6 6.4 7.5e-05 23.1 6.4 1.2 1 0 0 1 1 1 1 Beta defensin m_DGTX_Dc1a_b_c PF17491.2 EMC78274.1 - 0.15 12.8 4.4 0.2 12.3 4.4 1.3 1 0 0 1 1 1 0 Spider Toxins mu-diguetoxin-1 a, b and c Defensin_beta PF00711.19 EMC78275.1 - 6.3e-11 42.1 12.5 7.4e-11 41.9 12.5 1.1 1 0 0 1 1 1 1 Beta defensin Defensin_beta_2 PF13841.6 EMC78275.1 - 0.066 13.7 13.2 0.1 13.1 13.2 1.4 1 0 0 1 1 1 0 Beta defensin Peptidase_C1 PF00112.23 EMC78276.1 - 9.3e-68 228.6 2.3 1.1e-67 228.3 2.3 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Propeptide_C1 PF08127.13 EMC78276.1 - 1.4e-18 66.4 0.3 3.2e-18 65.3 0.3 1.6 1 0 0 1 1 1 1 Peptidase family C1 propeptide Peptidase_C1_2 PF03051.15 EMC78276.1 - 0.052 12.3 1.3 2.8 6.6 0.2 2.1 2 0 0 2 2 2 0 Peptidase C1-like family SQS_PSY PF00494.19 EMC78277.1 - 2.1e-42 145.5 0.0 2.8e-42 145.0 0.0 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase BLM10_mid PF16507.5 EMC78277.1 - 0.015 13.9 0.1 2 7.0 0.0 2.1 2 0 0 2 2 2 0 Proteasome-substrate-size regulator, mid region H2TH PF06831.14 EMC78278.1 - 2.2e-12 46.8 0.0 3.1e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain zf-FPG_IleRS PF06827.14 EMC78278.1 - 0.0063 16.4 0.3 0.014 15.2 0.3 1.6 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS zf-C3HC4_2 PF13923.6 EMC78279.1 - 1.4e-16 60.0 10.4 2.2e-16 59.4 10.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC78279.1 - 2.6e-11 43.2 10.3 3.7e-11 42.7 10.3 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC78279.1 - 1.5e-09 38.0 8.7 2.2e-09 37.5 8.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EMC78279.1 - 1.3e-08 34.5 7.9 1.7e-08 34.2 7.9 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC78279.1 - 1.3e-07 31.6 5.0 2.3e-07 30.7 5.0 1.6 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMC78279.1 - 8.5e-06 25.6 8.6 1.3e-05 25.1 8.6 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EMC78279.1 - 1.4e-05 25.1 7.9 2.4e-05 24.4 7.9 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 EMC78279.1 - 1.6e-05 24.7 5.4 2.1e-05 24.2 5.4 1.2 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 EMC78279.1 - 4.3e-05 23.3 4.0 6.6e-05 22.7 4.0 1.2 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 EMC78279.1 - 6.2e-05 22.7 7.3 0.00015 21.5 7.3 1.6 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 EMC78279.1 - 0.00027 21.1 7.8 0.00088 19.5 7.8 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EMC78279.1 - 0.0023 17.7 8.5 0.069 13.0 9.1 2.2 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_5 PF17121.5 EMC78279.1 - 0.012 15.5 8.3 0.057 13.3 8.2 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-UDP PF14569.6 EMC78279.1 - 0.045 13.9 4.8 0.1 12.7 4.8 1.5 1 1 0 1 1 1 0 Zinc-binding RING-finger zf-C4_Topoisom PF01396.19 EMC78279.1 - 0.072 12.9 0.9 0.072 12.9 0.9 1.9 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger zf-RING_11 PF17123.5 EMC78279.1 - 0.24 11.1 7.1 0.16 11.8 4.8 1.9 2 0 0 2 2 2 0 RING-like zinc finger DZR PF12773.7 EMC78279.1 - 0.37 10.9 7.2 5.1 7.2 4.5 2.4 1 1 1 2 2 2 0 Double zinc ribbon zf-MIZ PF02891.20 EMC78279.1 - 0.49 10.2 8.5 0.94 9.3 8.5 1.5 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger YacG PF03884.14 EMC78279.1 - 2.1 8.2 6.7 3.2 7.6 0.5 2.3 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG Glyco_transf_25 PF01755.17 EMC78280.1 - 1.7e-06 28.1 0.0 2e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) zf-C3HC4_2 PF13923.6 EMC78281.1 - 1e-12 47.6 9.0 1.6e-12 47.1 9.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC78281.1 - 4.7e-11 42.4 9.1 7.2e-11 41.8 9.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC78281.1 - 1.3e-09 38.2 10.4 1.9e-09 37.7 10.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EMC78281.1 - 1.4e-09 37.6 6.5 2.1e-09 37.1 6.5 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC78281.1 - 1.6e-06 28.0 6.5 2.4e-06 27.4 6.5 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC78281.1 - 5.5e-06 26.2 6.8 9.4e-06 25.4 6.8 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EMC78281.1 - 4.6e-05 23.3 8.1 8.9e-05 22.4 8.1 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 EMC78281.1 - 0.00012 22.3 10.1 0.00038 20.7 10.1 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EMC78281.1 - 0.0038 16.9 5.6 0.0078 15.9 5.6 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-ANAPC11 PF12861.7 EMC78281.1 - 0.07 13.2 2.9 0.13 12.3 2.9 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Baculo_IE-1 PF05290.11 EMC78281.1 - 0.22 11.5 5.0 0.34 10.9 5.0 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-C3HC4_4 PF15227.6 EMC78281.1 - 0.68 10.1 11.6 1.2 9.4 11.6 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EMC78281.1 - 1.1 9.0 8.3 2.2 8.2 8.3 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-H2C2_2 PF13465.6 EMC78282.1 - 1.4e-238 761.9 214.1 3.5e-08 33.5 0.4 35.4 36 0 0 36 36 35 34 Zinc-finger double domain zf-C2H2 PF00096.26 EMC78282.1 - 6.6e-186 593.2 275.9 1.3e-06 28.5 1.3 35.1 35 0 0 35 35 35 34 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC78282.1 - 2.9e-110 351.3 243.1 0.002 18.8 0.5 35.0 35 0 0 35 35 35 34 C2H2-type zinc finger zf-LYAR PF08790.11 EMC78282.1 - 2.3e-44 148.9 195.9 0.078 12.9 1.2 34.0 35 0 0 35 35 35 26 LYAR-type C2HC zinc finger zf-C2H2_8 PF15909.5 EMC78282.1 - 1.2e-34 118.5 130.9 0.00032 21.0 0.9 17.2 1 1 15 17 17 17 13 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 EMC78282.1 - 1.9e-30 104.5 132.5 4.1e-05 23.7 0.3 31.8 33 0 0 33 33 33 6 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 EMC78282.1 - 1.4e-23 82.7 150.1 0.029 14.5 1.3 22.6 4 3 25 31 31 31 24 Zinc ribbon domain CpXC PF14353.6 EMC78282.1 - 1e-19 70.7 125.0 0.88 9.6 0.1 30.5 3 2 22 30 30 30 4 CpXC protein zf_UBZ PF18439.1 EMC78282.1 - 1.6e-19 69.2 127.5 1.4 8.6 0.1 32.7 34 0 0 34 34 34 9 Ubiquitin-Binding Zinc Finger DUF3268 PF11672.8 EMC78282.1 - 1e-18 67.8 71.6 0.36 11.2 0.1 16.4 15 2 0 16 16 16 9 zinc-finger-containing domain LIM PF00412.22 EMC78282.1 - 5.5e-15 55.3 176.1 0.52 10.6 3.4 28.3 6 5 21 29 29 29 8 LIM domain zf-trcl PF13451.6 EMC78282.1 - 3.8e-14 52.3 164.6 1.3 8.9 0.1 33.0 33 1 1 34 34 34 6 Probable zinc-ribbon domain ADK_lid PF05191.14 EMC78282.1 - 4.7e-12 45.7 108.1 0.25 11.4 0.8 23.0 13 6 8 21 21 20 5 Adenylate kinase, active site lid YhfH PF14149.6 EMC78282.1 - 8.7e-12 44.8 107.8 1.7 8.7 0.1 28.8 31 0 0 31 31 30 2 YhfH-like protein zf-C2H2_6 PF13912.6 EMC78282.1 - 1.3e-11 44.2 214.0 0.033 14.2 0.2 33.7 34 0 0 34 34 34 7 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 EMC78282.1 - 2.1e-11 43.3 158.8 1.2 8.8 0.6 28.6 3 3 30 33 33 33 15 Zinc-fingers and homeoboxes C2H2 finger domain zf-AN1 PF01428.16 EMC78282.1 - 2.7e-09 37.0 190.2 4.8 7.4 1.7 33.3 28 5 6 34 34 34 1 AN1-like Zinc finger DUF2423 PF10338.9 EMC78282.1 - 4.5e-09 36.4 12.5 13 6.1 0.0 7.8 8 0 0 8 8 7 0 Protein of unknown function (DUF2423) zinc_ribbon_15 PF17032.5 EMC78282.1 - 8.3e-09 36.1 126.3 0.41 11.4 1.0 17.5 2 1 18 21 21 21 6 zinc-ribbon family DUF4712 PF15830.5 EMC78282.1 - 1.4e-05 25.0 7.7 8.7 5.9 0.0 7.9 1 1 7 10 10 10 0 Domain of unknown function (DUF4712) BHD_1 PF10403.9 EMC78282.1 - 2.2e-05 24.2 0.1 13 5.7 0.0 6.6 6 0 0 6 6 5 0 Rad4 beta-hairpin domain 1 zf-C2HE PF16278.5 EMC78282.1 - 0.00026 21.4 203.7 2.5 8.6 0.8 33.1 6 6 24 30 30 30 3 C2HE / C2H2 / C2HC zinc-binding finger DUF3656 PF12392.8 EMC78282.1 - 0.00048 20.7 7.0 67 4.2 0.0 9.5 5 4 3 8 8 8 0 Collagenase zf-met PF12874.7 EMC78282.1 - 0.024 15.1 0.4 0.024 15.1 0.4 31.1 33 0 0 33 33 32 0 Zinc-finger of C2H2 type DUF4934 PF16288.5 EMC78282.1 - 0.094 12.6 21.0 40 4.2 0.1 10.6 3 3 8 14 14 14 0 Domain of unknown function (DUF4934) FYDLN_acid PF09538.10 EMC78282.1 - 0.23 12.2 91.6 41 4.9 0.8 26.2 2 2 23 28 28 28 0 Protein of unknown function (FYDLN_acid) zf-C2HC_2 PF13913.6 EMC78282.1 - 1.2 9.1 166.4 0.57 10.2 0.4 27.3 32 0 0 32 32 28 0 zinc-finger of a C2HC-type KRAB PF01352.27 EMC78283.1 - 3e-21 74.8 0.2 3.3e-21 74.7 0.2 1.0 1 0 0 1 1 1 1 KRAB box Amidohydro_1 PF01979.20 EMC78284.1 - 9.9e-25 87.6 0.1 1.4e-24 87.0 0.1 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EMC78284.1 - 3.1e-08 33.5 0.0 8.7e-08 32.0 0.0 1.8 1 1 1 2 2 2 1 Amidohydrolase family Amidohydro_2 PF04909.14 EMC78284.1 - 0.0016 18.3 0.0 0.0027 17.5 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase AP_endonuc_2 PF01261.24 EMC78284.1 - 0.005 16.3 0.0 0.0071 15.8 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel BrnT_toxin PF04365.13 EMC78284.1 - 0.098 13.0 0.1 0.61 10.5 0.0 2.3 3 0 0 3 3 3 0 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system DUF1279 PF06916.13 EMC78285.1 - 4.6e-23 81.6 0.7 4.6e-23 81.6 0.7 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1279) LEA_4 PF02987.16 EMC78285.1 - 6.9e-06 26.0 10.2 6.9e-06 26.0 10.2 1.7 1 1 0 1 1 1 1 Late embryogenesis abundant protein Apolipoprotein PF01442.18 EMC78285.1 - 9.3e-05 22.4 0.3 0.00014 21.8 0.3 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain YtxH PF12732.7 EMC78285.1 - 0.00031 21.2 7.9 0.00031 21.2 7.9 2.0 3 0 0 3 3 3 1 YtxH-like protein DctP PF03480.13 EMC78285.1 - 0.035 13.4 0.2 0.051 12.9 0.2 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein, family 7 Mit_KHE1 PF10173.9 EMC78285.1 - 0.056 13.5 1.1 0.098 12.7 1.1 1.3 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related FUN14 PF04930.15 EMC78285.1 - 0.063 13.7 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 FUN14 family DUF883 PF05957.13 EMC78285.1 - 0.17 12.5 0.7 0.34 11.6 0.7 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Mt_ATP-synt_D PF05873.12 EMC78285.1 - 0.24 11.2 8.4 3.1 7.6 5.7 2.2 2 0 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) TMEM154 PF15102.6 EMC78286.1 - 0.039 13.9 1.1 0.076 12.9 1.1 1.5 1 0 0 1 1 1 0 TMEM154 protein family m04gp34like PF12216.8 EMC78286.1 - 0.053 13.1 0.5 0.11 12.0 0.3 1.6 2 0 0 2 2 2 0 Immune evasion protein Shisa PF13908.6 EMC78286.1 - 0.076 13.3 0.0 0.076 13.3 0.0 1.8 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator DUF4834 PF16118.5 EMC78286.1 - 0.17 12.8 1.7 0.3 12.0 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) HemY_N PF07219.13 EMC78286.1 - 0.22 11.7 0.3 0.35 11.1 0.3 1.2 1 0 0 1 1 1 0 HemY protein N-terminus SP_C-Propep PF08999.10 EMC78286.1 - 1.7 8.5 4.3 1.1 9.0 2.0 1.9 2 0 0 2 2 2 0 Surfactant protein C, N terminal propeptide ASH PF15780.5 EMC78287.1 - 9.8e-18 64.2 2.9 0.0045 17.2 0.2 8.1 8 1 0 8 8 8 4 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TMEM131_like PF12371.8 EMC78287.1 - 1.3e-09 38.1 2.4 0.017 15.4 0.1 6.5 6 1 0 6 6 6 2 Transmembrane protein 131-like MYCBPAP PF14646.6 EMC78287.1 - 5.8e-09 35.4 0.6 0.0002 20.4 0.0 3.8 4 0 0 4 4 4 2 MYCBP-associated protein family Motile_Sperm PF00635.26 EMC78287.1 - 2.2e-08 33.9 0.2 0.0018 18.1 0.0 4.5 4 1 1 5 5 5 2 MSP (Major sperm protein) domain DUF1573 PF07610.11 EMC78287.1 - 0.0089 16.0 0.0 3.1 7.9 0.0 4.6 4 1 0 4 4 4 1 Protein of unknown function (DUF1573) Transglut_C PF00927.22 EMC78287.1 - 0.011 15.9 0.0 29 4.9 0.0 4.6 4 0 0 4 4 4 0 Transglutaminase family, C-terminal ig like domain WD40 PF00400.32 EMC78290.1 - 4.6e-10 39.9 23.7 0.00017 22.3 1.9 5.8 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC78290.1 - 8.1e-07 29.3 1.8 0.021 15.1 0.3 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMC78290.1 - 0.00023 20.2 0.1 0.24 10.3 0.0 2.8 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Y_phosphatase PF00102.27 EMC78291.1 - 6.5e-76 255.0 0.1 6.5e-76 255.0 0.1 1.5 2 0 0 2 2 2 1 Protein-tyrosine phosphatase DSPc PF00782.20 EMC78291.1 - 0.0063 16.3 1.4 0.034 13.9 0.0 2.4 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC78291.1 - 0.028 14.4 0.0 0.074 13.0 0.0 1.7 1 0 0 1 1 1 0 Tyrosine phosphatase family PAC2 PF09754.9 EMC78292.1 - 9.7e-41 140.1 0.0 1.2e-40 139.9 0.0 1.1 1 0 0 1 1 1 1 PAC2 family CEP76-C2 PF15627.6 EMC78293.1 - 7.7e-62 207.5 0.0 1.6e-61 206.5 0.0 1.6 1 0 0 1 1 1 1 CEP76 C2 domain Transglut_core PF01841.19 EMC78293.1 - 0.0049 17.3 0.1 0.011 16.2 0.1 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_core3 PF13471.6 EMC78293.1 - 0.029 14.3 0.3 0.069 13.0 0.3 1.6 1 0 0 1 1 1 0 Transglutaminase-like superfamily KIND PF16474.5 EMC78294.1 - 8.1e-47 159.6 2.6 1.3e-46 158.9 0.8 2.2 2 0 0 2 2 2 1 Kinase non-catalytic C-lobe domain Muted PF14942.6 EMC78294.1 - 0.05 14.0 1.7 2.4 8.5 0.6 2.6 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein FYVE PF01363.21 EMC78294.1 - 0.14 12.3 14.7 0.36 11.0 14.7 1.7 1 1 0 1 1 1 0 FYVE zinc finger Peptidase_M41 PF01434.18 EMC78295.1 - 4.6e-66 222.3 0.0 6.8e-66 221.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EMC78295.1 - 1.9e-42 144.8 0.0 4.3e-42 143.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMC78295.1 - 1.4e-15 56.8 0.1 4e-15 55.3 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 EMC78295.1 - 1.4e-09 38.3 0.1 5.6e-09 36.3 0.1 2.1 1 0 0 1 1 1 1 FtsH Extracellular AAA_22 PF13401.6 EMC78295.1 - 0.00015 22.1 0.0 0.06 13.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EMC78295.1 - 0.00095 19.2 0.0 0.0037 17.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EMC78295.1 - 0.0015 18.6 0.0 0.0041 17.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EMC78295.1 - 0.0021 18.5 0.3 0.13 12.6 0.1 2.6 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EMC78295.1 - 0.0025 17.6 0.1 0.016 14.9 0.0 2.3 1 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EMC78295.1 - 0.0059 15.9 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 EMC78295.1 - 0.037 13.8 0.0 0.079 12.7 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.6 EMC78295.1 - 0.04 14.1 0.2 0.4 10.8 0.0 2.6 3 0 0 3 3 3 0 AAA domain Mg_chelatase PF01078.21 EMC78295.1 - 0.08 12.3 0.2 0.27 10.6 0.1 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EMC78295.1 - 0.098 12.7 0.0 0.25 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EMC78295.1 - 0.17 11.1 0.1 1.2 8.4 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin PhoH PF02562.16 EMC78295.1 - 0.2 11.1 0.5 0.63 9.5 0.2 1.9 2 0 0 2 2 2 0 PhoH-like protein FoP_duplication PF13865.6 EMC78295.1 - 4.2 8.0 10.1 34 5.1 0.0 2.8 3 0 0 3 3 2 0 C-terminal duplication domain of Friend of PRMT1 Tubulin PF00091.25 EMC78296.1 - 4.3e-53 180.4 0.0 7.7e-53 179.6 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EMC78296.1 - 4.6e-42 143.1 0.1 7.9e-42 142.4 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EMC78296.1 - 0.0082 15.8 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 EMC78296.1 - 0.02 14.1 0.0 0.037 13.2 0.0 1.4 1 0 0 1 1 1 0 Tubulin like CIDE-N PF02017.15 EMC78297.1 - 1.4e-30 105.2 0.1 3.3e-30 103.9 0.0 1.6 2 0 0 2 2 2 1 CIDE-N domain GCV_T PF01571.21 EMC78297.1 - 0.11 11.8 0.1 0.14 11.5 0.1 1.2 1 0 0 1 1 1 0 Aminomethyltransferase folate-binding domain Inositol_P PF00459.25 EMC78298.1 - 4.2e-76 256.0 0.1 4.7e-76 255.9 0.1 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family TMF_DNA_bd PF12329.8 EMC78299.1 - 0.00012 22.0 24.0 0.0032 17.4 5.5 2.9 2 1 0 2 2 2 2 TATA element modulatory factor 1 DNA binding PRKG1_interact PF15898.5 EMC78299.1 - 0.00018 22.4 10.1 0.00018 22.4 10.1 2.0 1 1 1 2 2 2 1 cGMP-dependent protein kinase interacting domain DivIC PF04977.15 EMC78299.1 - 0.0018 18.0 2.6 0.0018 18.0 2.6 3.4 2 2 1 3 3 3 1 Septum formation initiator Mod_r PF07200.13 EMC78299.1 - 0.0034 17.5 2.8 0.0034 17.5 2.8 2.1 2 0 0 2 2 2 1 Modifier of rudimentary (Mod(r)) protein TMF_TATA_bd PF12325.8 EMC78299.1 - 0.01 16.0 16.0 0.021 15.0 4.0 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding NRBF2 PF08961.10 EMC78299.1 - 0.011 15.4 4.4 0.011 15.4 4.4 2.1 1 1 1 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator Jnk-SapK_ap_N PF09744.9 EMC78299.1 - 0.012 15.8 7.8 0.012 15.8 7.8 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF4047 PF13256.6 EMC78299.1 - 0.021 15.0 1.3 0.021 15.0 1.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) MetOD2 PF18548.1 EMC78299.1 - 0.024 14.7 2.7 0.024 14.7 2.7 2.7 2 1 1 3 3 3 0 Metanogen output domain 2 DUF2935 PF11155.8 EMC78299.1 - 0.051 13.9 6.7 1 9.7 1.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) PsbQ PF05757.11 EMC78299.1 - 0.054 13.2 0.4 0.054 13.2 0.4 1.7 2 1 0 2 2 2 0 Oxygen evolving enhancer protein 3 (PsbQ) Seryl_tRNA_N PF02403.22 EMC78299.1 - 0.058 13.6 14.5 0.096 12.9 4.2 2.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ATG16 PF08614.11 EMC78299.1 - 0.071 13.3 13.3 0.18 12.0 2.7 2.3 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) ZapB PF06005.12 EMC78299.1 - 0.079 13.4 23.5 0.33 11.4 8.4 2.5 2 1 0 2 2 2 0 Cell division protein ZapB Arc_PepC_II PF06847.11 EMC78299.1 - 0.088 13.3 2.6 3.1 8.4 0.0 2.5 2 1 0 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II GAS PF13851.6 EMC78299.1 - 0.095 12.0 22.4 0.093 12.1 8.8 2.1 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF1664 PF07889.12 EMC78299.1 - 0.12 12.4 7.7 2.5 8.1 1.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) PikAIV_N PF18605.1 EMC78299.1 - 0.13 11.8 0.3 0.13 11.8 0.3 2.1 2 0 0 2 2 2 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain Syntaxin-6_N PF09177.11 EMC78299.1 - 0.21 12.2 11.9 0.31 11.6 1.8 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Syntaxin PF00804.25 EMC78299.1 - 0.24 11.1 10.7 0.66 9.6 10.5 1.9 1 1 0 1 1 1 0 Syntaxin NAPRTase_N PF17767.1 EMC78299.1 - 0.37 11.2 3.3 0.59 10.5 0.3 2.0 1 1 1 2 2 2 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain YABBY PF04690.13 EMC78299.1 - 0.38 11.3 5.3 0.63 10.6 5.3 1.3 1 0 0 1 1 1 0 YABBY protein Nmad5 PF18757.1 EMC78299.1 - 0.42 10.8 7.6 0.23 11.6 5.2 1.7 1 1 0 1 1 1 0 Nucleotide modification associated domain 5 Ax_dynein_light PF10211.9 EMC78299.1 - 0.46 10.4 17.1 0.82 9.6 5.6 2.1 2 0 0 2 2 2 0 Axonemal dynein light chain DUF812 PF05667.11 EMC78299.1 - 0.48 9.2 16.1 0.21 10.5 5.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF812) CENP-H PF05837.12 EMC78299.1 - 0.55 10.7 12.7 1 9.8 2.1 2.3 2 0 0 2 2 2 0 Centromere protein H (CENP-H) OmpH PF03938.14 EMC78299.1 - 0.59 10.5 13.0 0.1 12.9 3.0 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) BST2 PF16716.5 EMC78299.1 - 0.63 10.7 16.1 0.79 10.3 4.2 2.6 2 1 0 2 2 2 0 Bone marrow stromal antigen 2 Filament PF00038.21 EMC78299.1 - 0.7 9.4 17.3 0.09 12.3 4.8 2.2 1 1 1 2 2 2 0 Intermediate filament protein LMBR1 PF04791.16 EMC78299.1 - 0.79 8.6 9.6 0.99 8.2 9.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Leu_zip PF15294.6 EMC78299.1 - 0.91 9.0 16.1 0.098 12.2 6.2 2.1 1 1 1 2 2 2 0 Leucine zipper Spc24 PF08286.11 EMC78299.1 - 1 9.6 13.4 1.8 8.9 1.9 2.5 1 1 0 2 2 2 0 Spc24 subunit of Ndc80 APG6_N PF17675.1 EMC78299.1 - 1 9.9 23.9 2.4e+02 2.2 23.9 2.8 1 1 0 1 1 1 0 Apg6 coiled-coil region YabA PF06156.13 EMC78299.1 - 1.2 9.8 14.4 0.44 11.2 5.2 2.5 1 1 1 2 2 2 0 Initiation control protein YabA V_ATPase_I PF01496.19 EMC78299.1 - 1.3 6.9 9.7 1.6 6.5 9.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ubiquitin_4 PF18036.1 EMC78299.1 - 1.3 9.1 0.1 1.3 9.1 0.1 2.9 3 0 0 3 3 3 0 Ubiquitin-like domain HDV_ag PF01517.18 EMC78299.1 - 1.4 8.7 8.7 0.9 9.3 0.8 2.2 1 1 1 2 2 2 0 Hepatitis delta virus delta antigen DUF4140 PF13600.6 EMC78299.1 - 1.4 9.4 11.7 0.64 10.5 0.6 2.5 2 1 1 3 3 2 0 N-terminal domain of unknown function (DUF4140) Spc7 PF08317.11 EMC78299.1 - 1.5 7.6 20.8 0.21 10.5 6.9 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein Exonuc_VII_L PF02601.15 EMC78299.1 - 1.7 8.2 8.4 2.2 7.7 8.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1640 PF07798.11 EMC78299.1 - 1.7 8.7 14.2 0.049 13.7 3.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) HAP1_N PF04849.13 EMC78299.1 - 1.7 7.8 19.6 0.21 10.7 6.1 2.2 1 1 1 2 2 2 0 HAP1 N-terminal conserved region Cnn_1N PF07989.11 EMC78299.1 - 2.8 8.2 18.5 3.7 7.8 2.4 3.1 2 2 2 4 4 4 0 Centrosomin N-terminal motif 1 TSC22 PF01166.18 EMC78299.1 - 3.1 8.2 15.1 12 6.3 0.3 3.4 3 0 0 3 3 3 0 TSC-22/dip/bun family DUF3450 PF11932.8 EMC78299.1 - 3.4 6.9 13.0 0.77 9.0 2.0 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF3450) GIT_CC PF16559.5 EMC78299.1 - 4.2 7.3 8.2 3.2 7.7 0.2 2.8 2 1 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor ADIP PF11559.8 EMC78299.1 - 4.4 7.4 19.5 2.6 8.1 5.8 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding TPR_MLP1_2 PF07926.12 EMC78299.1 - 5.4 7.1 19.8 1.4 9.0 5.8 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF2205 PF10224.9 EMC78299.1 - 6 6.9 14.9 0.44 10.6 2.5 2.6 2 1 1 3 3 3 0 Short coiled-coil protein DUF848 PF05852.11 EMC78299.1 - 6.5 6.9 13.8 6.3 6.9 4.0 2.1 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) DUF4407 PF14362.6 EMC78299.1 - 6.8 6.0 9.1 13 5.1 9.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DHR10 PF18595.1 EMC78299.1 - 6.9 6.8 21.7 3.4 7.8 3.0 2.8 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain DUF4200 PF13863.6 EMC78299.1 - 7.8 6.9 24.0 11 6.5 7.5 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) SlyX PF04102.12 EMC78299.1 - 8.1 7.1 8.8 7.2 7.3 1.7 2.5 2 1 0 2 2 2 0 SlyX Rho_Binding PF08912.11 EMC78299.1 - 8.9 7.2 18.5 1.1 10.2 7.0 2.9 2 2 0 2 2 2 0 Rho Binding DUF4094 PF13334.6 EMC78299.1 - 9.5 6.7 8.3 13 6.3 1.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) Metallophos PF00149.28 EMC78300.1 - 5.9e-14 53.0 0.0 9.1e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EMC78300.1 - 0.00035 20.8 0.0 0.0022 18.2 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain SNAP PF14938.6 EMC78301.1 - 4.7e-25 88.6 12.5 6.3e-25 88.1 12.5 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_MalT PF17874.1 EMC78301.1 - 3.8e-05 23.2 9.2 0.0019 17.6 9.2 2.3 1 1 0 1 1 1 1 MalT-like TPR region Sulphotransf PF09037.10 EMC78301.1 - 0.013 15.1 0.2 0.4 10.2 0.1 2.1 1 1 1 2 2 2 0 Stf0 sulphotransferase TPR_14 PF13428.6 EMC78301.1 - 0.017 15.9 14.2 3.1 8.9 1.9 5.8 3 2 4 7 7 7 0 Tetratricopeptide repeat UPF0449 PF15136.6 EMC78301.1 - 0.052 14.0 2.3 0.9 10.0 0.2 2.7 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 DUF2150 PF09920.9 EMC78301.1 - 0.079 12.9 2.1 0.37 10.7 0.4 2.6 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2150) NSF PF02071.20 EMC78301.1 - 0.096 13.5 14.1 1.3 10.1 0.5 5.6 5 0 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat TPR_8 PF13181.6 EMC78301.1 - 3.7 8.0 9.9 28 5.3 0.1 5.3 4 1 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 EMC78301.1 - 6.6 7.3 18.6 1 9.9 4.6 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat Laminin_G_2 PF02210.24 EMC78302.1 - 8.6e-88 291.4 9.0 1.6e-25 90.1 1.3 4.3 4 0 0 4 4 4 4 Laminin G domain Laminin_G_1 PF00054.23 EMC78302.1 - 3.5e-66 221.3 0.9 2.6e-18 66.5 0.0 4.3 4 0 0 4 4 4 4 Laminin G domain F5_F8_type_C PF00754.25 EMC78302.1 - 5.3e-29 100.9 2.6 2e-28 99.1 0.3 2.9 3 0 0 3 3 3 1 F5/8 type C domain Laminin_G_3 PF13385.6 EMC78302.1 - 3.7e-11 43.4 4.3 0.00018 21.7 0.0 4.6 5 0 0 5 5 5 3 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.27 EMC78302.1 - 1.6e-06 28.2 32.5 0.00012 22.3 9.1 3.7 3 0 0 3 3 3 2 EGF-like domain PMP1_2 PF08114.11 EMC78302.1 - 0.087 12.6 0.2 0.18 11.6 0.2 1.5 1 0 0 1 1 1 0 ATPase proteolipid family hEGF PF12661.7 EMC78302.1 - 5.3 7.8 31.4 0.049 14.3 8.1 4.1 4 0 0 4 4 4 0 Human growth factor-like EGF Glycos_transf_4 PF00953.21 EMC78303.1 - 8.1e-37 126.7 16.1 8.1e-37 126.7 16.1 1.7 2 0 0 2 2 2 1 Glycosyl transferase family 4 Gal_mutarotas_2 PF13802.6 EMC78303.1 - 0.075 13.4 0.1 0.16 12.3 0.1 1.5 1 0 0 1 1 1 0 Galactose mutarotase-like DUF4133 PF13571.6 EMC78303.1 - 1.7 9.0 8.1 0.49 10.8 2.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4133) Porphobil_deam PF01379.20 EMC78304.1 - 9.7e-83 276.7 0.0 1.2e-82 276.3 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 EMC78304.1 - 7.5e-20 71.1 0.0 6.8e-19 68.0 0.0 2.3 1 1 1 2 2 2 1 Porphobilinogen deaminase, C-terminal domain CUE PF02845.16 EMC78304.1 - 0.007 16.1 0.1 0.69 9.7 0.1 2.6 2 0 0 2 2 2 1 CUE domain VPS11_C PF12451.8 EMC78305.1 - 1.5e-19 69.9 2.5 9.4e-19 67.4 0.4 2.8 2 0 0 2 2 2 1 Vacuolar protein sorting protein 11 C terminal Clathrin PF00637.20 EMC78305.1 - 3.1e-17 62.8 13.3 2.8e-15 56.4 3.1 2.7 2 0 0 2 2 2 2 Region in Clathrin and VPS zf-C3HC4_2 PF13923.6 EMC78305.1 - 3.1e-09 36.5 8.2 6.7e-09 35.5 8.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC78305.1 - 3.5e-08 33.6 8.8 8.6e-08 32.4 8.8 1.7 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EMC78305.1 - 4e-05 23.8 6.7 0.00011 22.4 6.7 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EMC78305.1 - 0.00015 21.6 8.0 0.00033 20.5 8.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3H2C3 PF17122.5 EMC78305.1 - 0.001 19.0 9.4 0.0026 17.8 9.4 1.7 1 0 0 1 1 1 1 Zinc-finger zf-RING_5 PF14634.6 EMC78305.1 - 0.0027 17.6 8.3 0.0066 16.4 8.3 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EMC78305.1 - 0.0095 15.9 9.5 0.028 14.4 9.5 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EMC78305.1 - 0.014 15.3 5.2 0.027 14.3 5.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Paralemmin PF03285.15 EMC78305.1 - 0.038 13.6 0.8 0.066 12.8 0.8 1.3 1 0 0 1 1 1 0 Paralemmin zf-ANAPC11 PF12861.7 EMC78305.1 - 0.053 13.6 2.2 0.18 11.9 2.2 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DLP_helical PF18709.1 EMC78305.1 - 0.087 12.0 2.5 0.22 10.7 2.5 1.6 1 0 0 1 1 1 0 Dynamin-like helical domain WASH_WAHD PF11945.8 EMC78305.1 - 0.16 11.4 2.8 1.1 8.7 0.1 2.2 2 0 0 2 2 2 0 WAHD domain of WASH complex DivIC PF04977.15 EMC78305.1 - 0.17 11.7 4.0 0.53 10.1 4.0 1.9 1 0 0 1 1 1 0 Septum formation initiator zf-C3HC4_4 PF15227.6 EMC78305.1 - 0.17 12.0 9.0 0.46 10.7 9.0 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING-like PF08746.11 EMC78305.1 - 0.23 11.8 7.2 0.74 10.2 7.2 1.9 1 0 0 1 1 1 0 RING-like domain zf-RING_11 PF17123.5 EMC78305.1 - 0.27 11.0 8.5 0.77 9.6 8.5 1.9 1 0 0 1 1 1 0 RING-like zinc finger Prefoldin_2 PF01920.20 EMC78305.1 - 0.28 11.2 10.3 6.3 6.8 4.6 4.1 4 0 0 4 4 4 0 Prefoldin subunit TPR_11 PF13414.6 EMC78305.1 - 0.38 10.5 4.4 1.7 8.4 0.0 3.9 5 0 0 5 5 5 0 TPR repeat TPR_2 PF07719.17 EMC78305.1 - 0.7 10.2 3.3 20 5.6 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat Zn_ribbon_17 PF17120.5 EMC78305.1 - 6.9 6.4 10.5 2.2 7.9 6.3 2.1 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type DEAD PF00270.29 EMC78306.1 - 1.4e-41 142.1 1.6 2.5e-41 141.4 0.4 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC78306.1 - 2.4e-28 98.7 0.7 3.5e-27 94.9 0.5 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.6 EMC78306.1 - 0.00074 18.9 0.2 0.0012 18.2 0.2 1.3 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.15 EMC78306.1 - 0.0014 18.7 0.0 0.0024 17.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit 7tm_1 PF00001.21 EMC78307.1 - 1.4e-52 178.6 19.8 1.8e-52 178.3 19.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC78307.1 - 6.4e-06 25.7 17.9 7.6e-06 25.5 17.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx CRPA PF05745.11 EMC78307.1 - 0.29 11.1 3.9 0.43 10.6 0.2 2.4 2 0 0 2 2 2 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) Yip1 PF04893.17 EMC78307.1 - 1.6 8.4 10.8 48 3.6 10.8 2.8 1 1 0 1 1 1 0 Yip1 domain CCDC84 PF14968.6 EMC78309.1 - 1.8e-45 156.1 2.1 2e-45 155.9 2.1 1.0 1 0 0 1 1 1 1 Coiled coil protein 84 Ribosomal_S25 PF03297.15 EMC78310.1 - 9.8e-42 141.3 0.3 1.1e-41 141.1 0.3 1.0 1 0 0 1 1 1 1 S25 ribosomal protein TrmB PF01978.19 EMC78310.1 - 0.077 12.9 0.2 0.15 12.0 0.1 1.6 1 1 1 2 2 2 0 Sugar-specific transcriptional regulator TrmB Fe_dep_repress PF01325.19 EMC78310.1 - 0.16 12.2 0.0 0.23 11.7 0.0 1.3 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain Adap_comp_sub PF00928.21 EMC78311.1 - 1.9e-21 76.6 0.0 2.2e-21 76.4 0.0 1.0 1 0 0 1 1 1 1 Adaptor complexes medium subunit family IFT46_B_C PF12317.8 EMC78312.1 - 2.1e-96 321.7 0.2 2.4e-96 321.5 0.2 1.0 1 0 0 1 1 1 1 Intraflagellar transport complex B protein 46 C terminal I-set PF07679.16 EMC78313.1 - 0.16 12.0 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain FYRC PF05965.14 EMC78314.1 - 7.2e-21 74.1 0.0 2e-20 72.7 0.0 1.8 1 0 0 1 1 1 1 F/Y rich C-terminus SET PF00856.28 EMC78314.1 - 7.6e-21 75.2 0.7 7.6e-21 75.2 0.7 4.4 5 0 0 5 5 5 1 SET domain FYRN PF05964.14 EMC78314.1 - 2.8e-16 59.1 0.2 6.2e-16 58.0 0.2 1.6 1 0 0 1 1 1 1 F/Y-rich N-terminus PHD PF00628.29 EMC78314.1 - 1.2e-14 53.9 55.7 1.5e-08 34.4 12.1 5.9 5 1 2 7 7 7 3 PHD-finger zf-CXXC PF02008.20 EMC78314.1 - 2.4e-13 49.8 24.3 2.4e-13 49.8 24.3 5.4 5 0 0 5 5 5 1 CXXC zinc finger domain zf-HC5HC2H PF13771.6 EMC78314.1 - 2.8e-10 40.3 11.0 2.8e-10 40.3 11.0 5.8 4 1 1 5 5 5 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EMC78314.1 - 8.5e-09 35.6 10.1 8.5e-09 35.6 10.1 5.3 4 1 1 5 5 5 1 PHD-zinc-finger like domain PHD_2 PF13831.6 EMC78314.1 - 0.00013 21.4 23.5 0.018 14.6 2.5 4.2 3 0 0 3 3 3 2 PHD-finger Bromodomain PF00439.25 EMC78314.1 - 0.022 14.8 0.0 0.2 11.8 0.0 2.4 2 0 0 2 2 2 0 Bromodomain PHD_4 PF16866.5 EMC78314.1 - 0.27 11.4 41.6 0.014 15.4 10.1 4.4 2 1 1 3 3 3 0 PHD-finger Ufd2P_core PF10408.9 EMC78315.1 - 3.1e-153 511.7 7.1 4.1e-153 511.3 7.1 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 EMC78315.1 - 2.1e-32 111.1 1.1 5.7e-32 109.7 0.6 2.1 2 0 0 2 2 2 1 U-box domain DASH_Dad3 PF08656.10 EMC78315.1 - 0.98 9.5 4.0 17 5.6 0.0 3.7 4 0 0 4 4 4 0 DASH complex subunit Dad3 IRK PF01007.20 EMC78316.1 - 2e-52 176.8 3.5 2.8e-52 176.3 3.5 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain IRK_C PF17655.1 EMC78316.1 - 8.3e-51 172.0 0.0 1.7e-50 171.0 0.0 1.6 1 1 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain Ion_trans_2 PF07885.16 EMC78316.1 - 0.00092 19.1 1.6 0.0011 18.8 0.6 1.7 1 1 0 1 1 1 1 Ion channel Neur_chan_LBD PF02931.23 EMC78317.1 - 5.8e-53 179.5 1.5 7.6e-53 179.2 1.5 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC78317.1 - 2.6e-30 106.3 0.0 3.3e-30 105.9 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region NNMT_PNMT_TEMT PF01234.17 EMC78319.1 - 1.1e-78 264.0 0.0 1.2e-78 263.9 0.0 1.0 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_23 PF13489.6 EMC78319.1 - 1.1e-07 31.9 0.0 1.4e-07 31.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC78319.1 - 1.7e-07 31.8 0.0 1.1e-05 26.0 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC78319.1 - 6.4e-06 26.8 0.0 0.13 13.0 0.0 2.2 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EMC78319.1 - 0.0022 18.7 0.0 0.024 15.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC78319.1 - 0.017 14.9 0.0 6.4 6.6 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain RNase_T PF00929.24 EMC78320.1 - 2.5e-24 86.7 0.0 3e-24 86.4 0.0 1.1 1 0 0 1 1 1 1 Exonuclease Ig_3 PF13927.6 EMC78321.1 - 2.1e-32 111.6 0.4 3.5e-14 53.2 0.1 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 EMC78321.1 - 1.4e-25 89.5 0.2 3.4e-10 40.1 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 EMC78321.1 - 4.1e-25 87.7 0.1 8.7e-11 41.7 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 EMC78321.1 - 4.9e-24 84.3 0.1 8.5e-10 38.7 0.0 3.8 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 EMC78321.1 - 6.5e-18 64.9 2.4 4.3e-07 30.1 0.1 4.5 3 1 1 4 4 4 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC78321.1 - 2e-12 47.0 0.0 1.8e-10 40.8 0.0 3.2 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 EMC78321.1 - 2.1e-05 24.5 0.0 0.19 11.8 0.0 2.6 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain Adeno_E3_CR1 PF02440.15 EMC78321.1 - 0.0025 17.5 2.0 0.19 11.5 0.0 3.0 4 0 0 4 4 3 1 Adenovirus E3 region protein CR1 C2-set PF05790.15 EMC78321.1 - 0.006 16.7 0.0 33 4.7 0.0 4.1 4 0 0 4 4 4 0 Immunoglobulin C2-set domain Syndecan PF01034.20 EMC78321.1 - 0.014 15.2 0.0 0.58 10.1 0.1 2.4 2 0 0 2 2 2 0 Syndecan domain C1-set PF07654.15 EMC78321.1 - 0.025 14.9 0.2 0.43 11.0 0.0 2.9 3 0 0 3 3 3 0 Immunoglobulin C1-set domain Ig_C17orf99 PF17736.1 EMC78321.1 - 0.088 12.9 0.0 0.65 10.1 0.0 2.4 3 1 0 3 3 3 0 C17orf99 Ig domain Mid2 PF04478.12 EMC78321.1 - 0.11 12.4 0.2 0.23 11.3 0.2 1.5 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor V-set_2 PF15910.5 EMC78321.1 - 0.2 11.8 1.3 3.7 7.7 0.1 3.0 2 1 1 3 3 3 0 ICOS V-set domain DUF3439 PF11921.8 EMC78321.1 - 1.4 8.9 10.5 3.1 7.8 10.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Bud13 PF09736.9 EMC78322.1 - 4.9e-47 160.0 14.0 4.9e-47 160.0 14.0 2.1 2 0 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex MRP-S26 PF14943.6 EMC78322.1 - 0.21 11.5 9.5 0.47 10.3 9.5 1.6 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 DUF2407_C PF13373.6 EMC78322.1 - 2.7 8.2 5.5 5.6 7.1 5.5 1.5 1 0 0 1 1 1 0 DUF2407 C-terminal domain DUF5542 PF17696.1 EMC78322.1 - 3.6 7.8 5.4 2.3 8.4 1.5 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5542) zf-ZPR1 PF03367.13 EMC78323.1 - 1e-92 308.2 0.0 3.5e-48 163.5 0.0 2.2 2 0 0 2 2 2 2 ZPR1 zinc-finger domain Ogr_Delta PF04606.12 EMC78323.1 - 0.028 14.4 2.0 0.069 13.1 2.0 1.7 1 0 0 1 1 1 0 Ogr/Delta-like zinc finger CpXC PF14353.6 EMC78323.1 - 0.11 12.5 0.8 0.48 10.5 0.8 2.0 1 1 0 1 1 1 0 CpXC protein Zn-ribbon_8 PF09723.10 EMC78323.1 - 1.6 8.9 4.5 20 5.4 0.1 2.9 3 0 0 3 3 3 0 Zinc ribbon domain PAS_4 PF08448.10 EMC78325.1 - 0.0085 16.3 0.0 0.47 10.7 0.0 2.0 1 1 1 2 2 2 2 PAS fold Peptidase_S8 PF00082.22 EMC78327.1 - 2.9e-39 135.1 0.5 3.5e-39 134.9 0.5 1.1 1 0 0 1 1 1 1 Subtilase family WW PF00397.26 EMC78328.1 - 6.5e-07 29.3 0.3 1e-06 28.7 0.3 1.3 1 0 0 1 1 1 1 WW domain ATP1G1_PLM_MAT8 PF02038.16 EMC78329.1 - 1.3e-19 69.3 0.2 1.7e-19 68.9 0.2 1.2 1 0 0 1 1 1 1 ATP1G1/PLM/MAT8 family ATP1G1_PLM_MAT8 PF02038.16 EMC78331.1 - 5.9e-26 89.6 0.0 9.2e-26 89.0 0.0 1.3 1 0 0 1 1 1 1 ATP1G1/PLM/MAT8 family Glycophorin_A PF01102.18 EMC78331.1 - 0.098 12.9 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 Glycophorin A EphA2_TM PF14575.6 EMC78331.1 - 0.14 13.1 0.1 0.37 11.7 0.0 1.7 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Trypsin PF00089.26 EMC78332.1 - 9.3e-73 244.7 4.1 7.5e-72 241.7 0.8 2.0 2 0 0 2 2 2 1 Trypsin SRCR_2 PF15494.6 EMC78332.1 - 4.6e-20 72.0 4.5 1e-19 70.8 4.5 1.6 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 EMC78332.1 - 1.1e-10 41.9 3.1 3.3e-10 40.5 3.1 1.8 1 1 0 1 1 1 1 Hepsin, SRCR domain Trypsin_2 PF13365.6 EMC78332.1 - 4.3e-07 30.9 0.0 8.5e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 EMC78332.1 - 9e-07 29.3 0.0 2e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) DUF316 PF03761.15 EMC78332.1 - 2e-05 24.3 0.1 0.17 11.4 0.1 2.3 2 0 0 2 2 2 2 Chymotrypsin family Peptidase-S1 SRCR PF00530.18 EMC78332.1 - 3.9e-05 24.1 1.1 3.9e-05 24.1 1.1 2.1 2 1 0 2 2 2 1 Scavenger receptor cysteine-rich domain Ldl_recept_a PF00057.18 EMC78332.1 - 0.00025 21.2 3.3 0.0011 19.2 3.3 2.1 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Trypsin PF00089.26 EMC78333.1 - 3.7e-70 236.2 0.3 4.4e-70 235.9 0.3 1.1 1 0 0 1 1 1 1 Trypsin SRCR_2 PF15494.6 EMC78333.1 - 1.3e-17 64.1 0.0 2.8e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Trypsin_2 PF13365.6 EMC78333.1 - 8.1e-09 36.5 0.1 1.8e-08 35.4 0.0 1.6 2 0 0 2 2 2 1 Trypsin-like peptidase domain Hepsin-SRCR PF09272.10 EMC78333.1 - 4.7e-07 30.3 1.8 5.3e-06 26.9 1.8 2.2 1 1 0 1 1 1 1 Hepsin, SRCR domain DUF1986 PF09342.11 EMC78333.1 - 0.00016 22.1 0.0 0.00025 21.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) SRCR PF00530.18 EMC78333.1 - 0.00086 19.8 0.0 0.0023 18.4 0.0 1.8 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain V-set PF07686.17 EMC78334.1 - 9e-11 41.9 0.1 2.3e-10 40.6 0.1 1.6 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC78334.1 - 2.1e-09 37.8 0.1 4.3e-09 36.8 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC78334.1 - 9.8e-08 32.1 0.2 3e-07 30.5 0.2 1.7 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC78334.1 - 6.6e-07 29.3 0.1 3.1e-06 27.2 0.1 2.1 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC78334.1 - 2e-05 24.8 0.5 0.00042 20.6 0.5 2.2 1 1 0 1 1 1 1 Immunoglobulin domain Glycophorin_A PF01102.18 EMC78334.1 - 0.0021 18.3 0.0 0.0034 17.6 0.0 1.4 1 0 0 1 1 1 1 Glycophorin A Izumo-Ig PF16706.5 EMC78334.1 - 0.013 15.5 0.1 0.04 14.0 0.1 2.0 1 1 0 1 1 1 0 Izumo-like Immunoglobulin domain DUF5305 PF17231.2 EMC78334.1 - 0.051 13.0 0.1 0.071 12.5 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Ig_6 PF18452.1 EMC78334.1 - 0.094 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain ResB PF05140.14 EMC78334.1 - 0.13 10.9 0.0 0.15 10.8 0.0 1.1 1 0 0 1 1 1 0 ResB-like family V-set PF07686.17 EMC78335.1 - 2e-21 76.2 0.5 3.5e-21 75.4 0.5 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 EMC78335.1 - 1.5e-06 28.3 4.7 2.3e-06 27.7 0.8 2.5 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 EMC78335.1 - 3.1e-06 27.2 0.0 1.4e-05 25.1 0.0 2.0 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC78335.1 - 0.00013 22.5 1.2 0.0011 19.5 1.2 2.2 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC78335.1 - 0.00026 21.3 3.8 0.0015 18.9 3.8 2.0 1 1 0 1 1 1 1 Immunoglobulin domain EphA2_TM PF14575.6 EMC78335.1 - 0.0016 19.3 0.0 0.0027 18.6 0.0 1.4 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain FAM176 PF14851.6 EMC78335.1 - 0.0096 15.6 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 1 FAM176 family Syndecan PF01034.20 EMC78335.1 - 0.063 13.2 0.0 0.36 10.8 0.0 2.0 2 0 0 2 2 2 0 Syndecan domain CcmH PF03918.14 EMC78335.1 - 0.066 12.5 0.4 0.65 9.3 0.0 2.4 3 0 0 3 3 3 0 Cytochrome C biogenesis protein Adeno_E3_CR2 PF02439.15 EMC78335.1 - 0.069 12.9 0.1 0.13 12.1 0.1 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 FAM163 PF15069.6 EMC78335.1 - 0.077 13.5 0.2 2.1 8.8 0.0 2.1 2 0 0 2 2 2 0 FAM163 family Cadherin_C_2 PF16492.5 EMC78335.1 - 0.083 13.7 0.0 0.31 11.8 0.0 2.0 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal Herpes_gE PF02480.16 EMC78335.1 - 0.086 11.6 0.1 0.33 9.6 0.0 1.6 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein E PALP PF00291.25 EMC78335.1 - 0.11 11.9 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme LST1 PF05083.13 EMC78335.1 - 0.15 12.4 0.1 0.3 11.4 0.1 1.5 1 0 0 1 1 1 0 LST-1 protein Ig_4 PF16680.5 EMC78335.1 - 0.3 11.4 5.7 2.8 8.2 0.0 3.0 3 0 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain V-set PF07686.17 EMC78336.1 - 4.7e-12 46.0 0.2 1.7e-10 41.0 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_6 PF18452.1 EMC78336.1 - 0.00019 21.0 0.0 0.00047 19.7 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 EMC78336.1 - 0.016 15.4 0.0 0.032 14.4 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Ig_3 PF13927.6 EMC78336.1 - 0.067 13.8 0.1 0.17 12.5 0.0 1.7 2 0 0 2 2 2 0 Immunoglobulin domain stn_TNFRSF12A PF12191.8 EMC78336.1 - 0.077 13.2 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain DUF4381 PF14316.6 EMC78336.1 - 0.083 13.1 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Herpes_gE PF02480.16 EMC78336.1 - 0.11 11.2 0.1 0.54 8.9 0.0 1.8 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein E V-set PF07686.17 EMC78338.1 - 6e-17 61.8 0.0 7.9e-17 61.4 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 EMC78338.1 - 2.8e-05 24.2 0.0 5.8e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC78338.1 - 6.5e-05 23.5 0.0 0.00013 22.5 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC78338.1 - 0.02 15.0 0.0 0.067 13.3 0.0 1.8 1 1 0 1 1 1 0 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC78338.1 - 0.025 14.9 0.1 0.71 10.3 0.1 2.2 1 1 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 EMC78339.1 - 5.3e-24 84.5 0.1 8.3e-24 83.9 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 EMC78339.1 - 5.8e-08 32.8 0.6 1.4e-07 31.5 0.2 1.8 2 1 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 EMC78339.1 - 9.9e-07 29.3 0.7 2.4e-06 28.0 0.7 1.7 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC78339.1 - 1e-05 25.5 0.0 2.1e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC78339.1 - 0.00021 21.5 0.5 0.0033 17.7 0.5 2.2 1 1 0 1 1 1 1 Immunoglobulin domain TMEM154 PF15102.6 EMC78339.1 - 0.004 17.1 0.0 0.0057 16.6 0.0 1.3 1 0 0 1 1 1 1 TMEM154 protein family EphA2_TM PF14575.6 EMC78339.1 - 0.0073 17.2 0.1 0.012 16.4 0.1 1.3 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain TMEM51 PF15345.6 EMC78339.1 - 0.03 14.2 0.0 0.045 13.6 0.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 FAM176 PF14851.6 EMC78339.1 - 0.11 12.2 0.2 0.16 11.6 0.2 1.2 1 0 0 1 1 1 0 FAM176 family Syndecan PF01034.20 EMC78339.1 - 0.14 12.1 0.0 0.3 11.0 0.0 1.6 1 0 0 1 1 1 0 Syndecan domain FGFR3_TM PF18123.1 EMC78339.1 - 1.5 8.4 5.9 2.9 7.5 5.9 1.5 1 0 0 1 1 1 0 Fibroblast growth factor receptor 3 transmembrane domain Vpu PF00558.19 EMC78339.1 - 2.8 7.8 5.8 0.22 11.3 0.8 1.7 2 0 0 2 2 2 0 Vpu protein Ig_5 PF16681.5 EMC78340.1 - 1.3e-13 51.1 0.1 1.9e-13 50.6 0.1 1.2 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 EMC78340.1 - 8.2e-08 32.4 0.1 1.3e-07 31.7 0.1 1.4 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 delta chain ITAM PF02189.15 EMC78340.1 - 0.004 17.5 0.0 0.0076 16.6 0.0 1.5 1 0 0 1 1 1 1 Immunoreceptor tyrosine-based activation motif Me-amine-dh_L PF02975.14 EMC78340.1 - 0.073 13.6 0.2 0.14 12.7 0.2 1.5 1 1 0 1 1 1 0 Methylamine dehydrogenase, L chain Ig_4 PF16680.5 EMC78341.1 - 1.4e-27 95.7 0.0 2.2e-27 95.1 0.0 1.3 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 EMC78341.1 - 9.5e-10 38.8 0.0 1.6e-09 38.1 0.0 1.3 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain ITAM PF02189.15 EMC78341.1 - 7.6e-07 29.2 0.8 1.7e-06 28.2 0.8 1.6 1 0 0 1 1 1 1 Immunoreceptor tyrosine-based activation motif Ig_2 PF13895.6 EMC78341.1 - 0.0038 17.5 0.0 0.0073 16.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC78341.1 - 0.028 15.0 0.3 0.077 13.6 0.1 1.8 2 1 0 2 2 2 0 Immunoglobulin domain DAP10 PF07213.11 EMC78341.1 - 0.03 14.3 0.2 0.052 13.5 0.2 1.4 1 0 0 1 1 1 0 DAP10 membrane protein ig PF00047.25 EMC78341.1 - 0.1 12.8 0.4 3.6 7.8 0.4 2.2 1 1 0 1 1 1 0 Immunoglobulin domain Zw10 PF06248.13 EMC78342.1 - 1.2e-176 588.5 14.2 1.7e-176 588.0 14.2 1.2 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 Reovirus_M2 PF05993.12 EMC78342.1 - 0.073 11.2 0.0 0.12 10.5 0.0 1.2 1 0 0 1 1 1 0 Reovirus major virion structural protein Mu-1/Mu-1C (M2) Thiamine_BP PF01910.17 EMC78342.1 - 0.096 12.6 0.1 1.8 8.5 0.0 2.5 2 0 0 2 2 2 0 Thiamine-binding protein 7tm_1 PF00001.21 EMC78343.1 - 2.7e-84 282.6 11.0 3.9e-84 282.1 11.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC78343.1 - 5.3e-18 65.3 22.2 2.2e-13 50.2 14.8 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 EMC78343.1 - 1.6e-05 24.4 25.4 0.0021 17.5 17.6 2.3 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srt PF10321.9 EMC78343.1 - 0.0002 20.4 19.0 0.011 14.7 1.2 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srt 7tm_4 PF13853.6 EMC78343.1 - 0.00063 19.6 13.1 0.00063 19.6 13.1 2.5 2 1 0 2 2 2 1 Olfactory receptor CcmH PF03918.14 EMC78343.1 - 0.027 13.8 0.0 0.82 9.0 0.0 2.4 2 0 0 2 2 2 0 Cytochrome C biogenesis protein RAMP4 PF06624.12 EMC78343.1 - 0.033 14.2 0.1 0.96 9.6 0.0 2.7 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 RIFIN PF02009.16 EMC78343.1 - 0.065 13.1 0.5 0.065 13.1 0.5 1.8 2 0 0 2 2 2 0 Rifin DUF3806 PF12713.7 EMC78343.1 - 0.067 13.0 1.4 3.6 7.4 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF3806) DUF4307 PF14155.6 EMC78343.1 - 0.086 12.7 0.0 0.086 12.7 0.0 3.1 4 1 1 5 5 5 0 Domain of unknown function (DUF4307) DUF1230 PF06799.11 EMC78343.1 - 0.37 10.9 6.2 2.3 8.3 0.8 2.6 2 0 0 2 2 2 0 Conserved in the green lineage and diatoms 27 Stevor PF17410.2 EMC78343.1 - 0.9 9.0 3.7 2.2 7.8 3.7 1.6 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Orf78 PF06024.12 EMC78343.1 - 1 9.7 8.8 3.9 7.8 0.6 3.7 3 1 0 3 3 3 0 Orf78 (ac78) Virul_fac_BrkB PF03631.15 EMC78343.1 - 1.2 8.6 14.2 0.039 13.6 1.0 2.9 3 0 0 3 3 3 0 Virulence factor BrkB DUF2207 PF09972.9 EMC78343.1 - 6.2 5.5 11.1 11 4.6 0.0 3.0 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Ank_2 PF12796.7 EMC78344.1 - 8e-88 289.1 10.1 9.4e-15 55.0 0.0 6.5 1 1 5 7 7 7 7 Ankyrin repeats (3 copies) Ank PF00023.30 EMC78344.1 - 1.8e-77 252.6 9.5 4.9e-07 29.9 0.0 12.1 12 0 0 12 12 12 12 Ankyrin repeat Ank_3 PF13606.6 EMC78344.1 - 1.2e-70 225.0 11.3 1.9e-05 24.7 0.0 12.0 12 0 0 12 12 12 12 Ankyrin repeat Ank_4 PF13637.6 EMC78344.1 - 7.1e-68 224.2 11.4 5e-10 39.7 0.1 9.1 2 2 9 11 11 11 10 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC78344.1 - 2.3e-52 174.4 8.7 6.2e-12 45.5 0.1 8.3 2 2 6 9 9 9 8 Ankyrin repeats (many copies) DUF4792 PF16040.5 EMC78344.1 - 0.00044 20.1 0.0 0.6 10.0 0.0 3.8 4 1 1 5 5 5 2 Domain of unknown function (DUF4792) Pkinase_Tyr PF07714.17 EMC78345.1 - 1.5e-46 158.8 0.0 1.9e-46 158.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC78345.1 - 1.1e-45 156.1 0.0 1.5e-45 155.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EMC78345.1 - 0.027 14.4 0.0 0.12 12.3 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EMC78345.1 - 0.083 11.8 0.0 0.14 11.1 0.0 1.5 2 0 0 2 2 2 0 Haspin like kinase domain I-set PF07679.16 EMC78347.1 - 1.4e-77 255.8 5.8 5.8e-19 67.9 0.1 5.5 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC78347.1 - 1.7e-69 230.4 8.4 1.2e-16 61.1 0.1 6.1 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 EMC78347.1 - 1.3e-49 166.3 2.1 2.4e-10 40.5 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.6 EMC78347.1 - 3.4e-43 145.8 2.4 1.1e-09 38.5 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain fn3 PF00041.21 EMC78347.1 - 5e-26 90.9 0.3 3.2e-13 49.8 0.1 3.1 2 0 0 2 2 2 2 Fibronectin type III domain V-set PF07686.17 EMC78347.1 - 9.4e-19 67.6 6.6 0.00035 20.7 0.0 7.6 5 4 0 5 5 5 4 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC78347.1 - 7.6e-13 48.3 0.3 0.012 15.7 0.0 5.2 5 0 0 5 5 5 3 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 EMC78347.1 - 1.7e-09 37.9 2.2 0.37 11.2 0.1 6.0 5 2 0 5 5 5 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 EMC78347.1 - 1.1e-08 35.0 0.1 0.46 10.6 0.0 5.0 5 0 0 5 5 5 2 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 EMC78347.1 - 2.2e-08 34.2 2.3 2 8.7 0.0 6.4 5 2 0 5 5 5 2 T-cell surface glycoprotein CD3 delta chain C1-set PF07654.15 EMC78347.1 - 5.2e-08 33.2 4.4 0.0018 18.6 0.0 5.4 5 0 0 5 5 5 1 Immunoglobulin C1-set domain Ig_C17orf99 PF17736.1 EMC78347.1 - 2.3e-07 30.7 0.1 0.93 9.6 0.0 4.7 4 0 0 4 4 4 3 C17orf99 Ig domain Ig_6 PF18452.1 EMC78347.1 - 3.2e-05 23.4 0.0 5.7 6.6 0.0 4.7 5 0 0 5 5 5 1 Immunoglobulin domain Receptor_2B4 PF11465.8 EMC78347.1 - 0.00018 21.6 0.6 0.17 12.1 0.0 4.1 4 0 0 4 4 4 1 Natural killer cell receptor 2B4 Collagen_bind_2 PF12904.7 EMC78347.1 - 0.069 13.1 0.2 1.5 8.8 0.1 2.9 2 0 0 2 2 2 0 Putative collagen-binding domain of a collagenase Pur_ac_phosph_N PF16656.5 EMC78347.1 - 0.11 13.0 6.0 0.13 12.8 0.1 4.0 3 2 0 3 3 3 0 Purple acid Phosphatase, N-terminal domain PTPS PF01242.19 EMC78349.1 - 1.1e-31 109.4 0.0 1.3e-31 109.1 0.0 1.0 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase RPE65 PF03055.15 EMC78350.1 - 2e-132 442.7 0.1 2.4e-132 442.4 0.1 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein IL1 PF00340.19 EMC78351.1 - 3.8e-11 42.7 0.5 5.7e-11 42.1 0.5 1.2 1 0 0 1 1 1 1 Interleukin-1 / 18 CybS PF05328.12 EMC78352.1 - 9.6e-23 80.3 0.6 1.2e-22 80.0 0.6 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit NKAP PF15692.5 EMC78353.1 - 5.3e-22 78.3 27.7 5.3e-22 78.3 27.7 5.2 2 1 3 5 5 5 1 NF-kappa-B-activating protein CDC27 PF09507.10 EMC78353.1 - 0.13 11.6 48.9 0.15 11.4 48.9 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Macoilin PF09726.9 EMC78353.1 - 4.6 5.7 34.5 5.8 5.3 34.5 1.1 1 0 0 1 1 1 0 Macoilin family 2-oxoacid_dh PF00198.23 EMC78354.1 - 1.5e-80 270.0 0.1 1.9e-80 269.7 0.1 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EMC78354.1 - 3.5e-33 113.3 0.4 1.9e-15 56.4 0.0 2.4 2 0 0 2 2 2 2 Biotin-requiring enzyme E3_binding PF02817.17 EMC78354.1 - 4.2e-18 65.4 0.4 1.3e-17 63.8 0.4 1.9 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 EMC78354.1 - 9.2e-07 28.6 0.0 0.0069 16.2 0.0 3.0 2 0 0 2 2 2 2 Biotin-lipoyl like DUF2118 PF09891.9 EMC78354.1 - 0.069 13.1 0.0 7.3 6.5 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) HlyD_3 PF13437.6 EMC78354.1 - 0.072 13.8 0.1 19 6.0 0.0 2.9 3 0 0 3 3 3 0 HlyD family secretion protein QRPTase_N PF02749.16 EMC78354.1 - 0.086 12.9 0.0 3 8.0 0.0 2.4 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, N-terminal domain Pou PF00157.17 EMC78355.1 - 3.1e-38 129.6 0.6 6.7e-38 128.5 0.2 1.8 2 0 0 2 2 2 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 EMC78355.1 - 1.5e-18 66.4 3.3 4e-18 65.0 3.3 1.8 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC78355.1 - 0.073 13.0 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Homeobox KN domain HTH_3 PF01381.22 EMC78355.1 - 0.14 12.2 0.2 1.4 9.1 0.0 2.3 2 1 0 2 2 2 0 Helix-turn-helix OAF PF14941.6 EMC78356.1 - 2.5e-93 312.0 5.5 2.7e-93 311.9 5.5 1.0 1 0 0 1 1 1 1 Transcriptional regulator, Out at first zf-B_box PF00643.24 EMC78357.1 - 1.8e-10 40.8 16.8 3.8e-10 39.7 5.7 2.4 2 0 0 2 2 2 2 B-box zinc finger C5HCH PF17982.1 EMC78357.1 - 4 7.7 11.4 0.073 13.2 2.9 2.3 2 0 0 2 2 2 0 NSD Cys-His rich domain C2-set_2 PF08205.12 EMC78358.1 - 1.5e-19 69.8 0.7 3.8e-18 65.3 0.1 2.6 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 EMC78358.1 - 1.3e-18 67.1 0.7 2.2e-15 56.8 0.0 3.5 3 1 0 3 3 3 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC78358.1 - 1.3e-16 60.9 1.5 7.1e-07 29.7 0.1 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 EMC78358.1 - 5.8e-16 58.4 0.7 1.1e-06 28.7 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 EMC78358.1 - 6.1e-13 48.9 3.1 4.4e-06 27.0 0.1 3.8 3 1 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 EMC78358.1 - 5e-07 29.7 0.1 0.002 18.2 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_6 PF18452.1 EMC78358.1 - 0.0066 16.0 0.0 4.4 6.9 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain EphA2_TM PF14575.6 EMC78358.1 - 0.013 16.3 0.0 0.03 15.2 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.20 EMC78358.1 - 0.036 14.0 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 Syndecan domain C1-set PF07654.15 EMC78358.1 - 0.098 13.0 0.5 2.6 8.5 0.0 2.5 2 0 0 2 2 2 0 Immunoglobulin C1-set domain ig PF00047.25 EMC78359.1 - 3.1e-06 27.3 0.3 5.2e-06 26.5 0.3 1.3 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC78359.1 - 5.4e-06 26.5 0.6 9e-06 25.8 0.6 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC78359.1 - 0.00016 22.2 0.2 0.00026 21.5 0.2 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC78359.1 - 0.017 15.2 0.4 0.03 14.4 0.4 1.6 1 1 0 1 1 1 0 Immunoglobulin I-set domain Herpes_gE PF02480.16 EMC78359.1 - 0.024 13.4 0.5 0.029 13.1 0.5 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E RPA_C PF08784.11 EMC78359.1 - 0.058 14.1 0.0 0.073 13.7 0.0 1.3 1 0 0 1 1 1 0 Replication protein A C terminal PAN_4 PF14295.6 EMC78359.1 - 0.1 12.5 0.0 0.25 11.3 0.0 1.7 1 0 0 1 1 1 0 PAN domain Izumo-Ig PF16706.5 EMC78359.1 - 0.11 12.6 0.2 0.18 11.9 0.2 1.6 1 1 0 1 1 1 0 Izumo-like Immunoglobulin domain UCH PF00443.29 EMC78360.1 - 2.4e-74 250.1 1.3 2.9e-74 249.8 1.3 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMC78360.1 - 1.2e-22 81.0 6.5 2.5e-22 79.9 6.5 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Palm_thioest PF02089.15 EMC78360.1 - 0.029 14.2 2.1 0.08 12.8 0.4 2.2 2 1 1 3 3 3 0 Palmitoyl protein thioesterase CUB PF00431.20 EMC78362.1 - 1.5e-24 86.5 0.0 2.3e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 CUB domain Fz PF01392.22 EMC78362.1 - 2.5e-24 86.0 0.5 2.5e-24 86.0 0.5 1.7 2 0 0 2 2 2 1 Fz domain Ldl_recept_a PF00057.18 EMC78362.1 - 2.3e-10 40.5 8.8 2.3e-10 40.5 8.8 2.2 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A C1q PF00386.21 EMC78363.1 - 1.4e-36 125.5 0.0 1.7e-36 125.2 0.0 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 EMC78363.1 - 2.1e-10 40.2 33.2 6e-08 32.3 33.2 2.2 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) FSAP_sig_propep PF03032.15 EMC78363.1 - 0.075 13.1 0.6 0.11 12.5 0.6 1.3 1 0 0 1 1 1 0 Frog skin active peptide family signal and propeptide zf-C3HC4_3 PF13920.6 EMC78364.1 - 8.2e-15 54.4 12.7 9.5e-15 54.2 12.7 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC78364.1 - 9.1e-09 35.0 10.3 1.3e-08 34.6 10.3 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EMC78364.1 - 1.3e-06 28.6 12.3 1.7e-06 28.2 12.3 1.2 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EMC78364.1 - 0.0014 18.5 13.9 0.0039 17.1 13.6 1.8 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EMC78364.1 - 0.0019 18.0 13.7 0.0033 17.3 13.6 1.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EMC78364.1 - 0.051 13.6 6.8 0.082 13.0 6.8 1.3 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EMC78364.1 - 0.48 10.5 10.7 0.35 10.9 8.0 2.0 1 1 1 2 2 2 0 RING-type zinc-finger zf-P11 PF03854.14 EMC78364.1 - 0.94 9.2 11.7 1.9 8.2 11.7 1.5 1 1 0 1 1 1 0 P-11 zinc finger Vfa1 PF08432.10 EMC78364.1 - 1.7 9.0 5.0 0.89 9.9 3.5 1.3 1 1 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Ig_3 PF13927.6 EMC78366.1 - 2.6e-29 101.6 0.7 3.2e-11 43.6 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 EMC78366.1 - 2.8e-27 94.9 0.6 1.1e-08 35.3 0.0 3.6 3 1 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 EMC78366.1 - 7.8e-20 70.8 1.6 1.3e-05 25.3 0.3 3.8 3 1 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.12 EMC78366.1 - 1.8e-18 66.4 0.1 1.7e-17 63.3 0.1 2.4 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain I-set PF07679.16 EMC78366.1 - 6.1e-16 58.3 0.1 1.9e-06 27.8 0.0 3.8 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_4 PF16680.5 EMC78366.1 - 3.7e-08 33.5 2.3 0.45 10.8 0.0 4.2 3 1 0 3 3 3 3 T-cell surface glycoprotein CD3 delta chain V-set PF07686.17 EMC78366.1 - 5.7e-07 29.7 3.8 0.015 15.5 0.1 4.9 3 3 2 5 5 5 2 Immunoglobulin V-set domain Ig_5 PF16681.5 EMC78366.1 - 8.2e-06 26.1 0.1 0.23 11.9 0.0 3.4 3 1 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C1-set PF07654.15 EMC78366.1 - 3.7e-05 24.0 1.9 0.00023 21.5 0.2 2.8 3 1 0 3 3 3 1 Immunoglobulin C1-set domain TOBE_2 PF08402.10 EMC78366.1 - 0.073 13.2 0.0 1 9.6 0.0 2.3 2 0 0 2 2 2 0 TOBE domain PDZ PF00595.24 EMC78367.1 - 3e-38 130.0 0.0 6.7e-12 45.6 0.0 3.1 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 EMC78367.1 - 6.6e-34 115.5 6.2 5.4e-11 42.2 0.6 3.2 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 EMC78367.1 - 1.2e-21 76.8 0.0 2.5e-07 30.9 0.0 3.1 3 0 0 3 3 3 3 PDZ domain Tricorn_PDZ PF14685.6 EMC78367.1 - 6.3e-06 26.1 0.3 0.37 10.8 0.0 3.2 3 0 0 3 3 3 3 Tricorn protease PDZ domain Mur_ligase PF01225.25 EMC78367.1 - 0.15 12.4 0.1 1.8 9.0 0.0 2.4 2 0 0 2 2 2 0 Mur ligase family, catalytic domain ABC2_membrane PF01061.24 EMC78369.1 - 4.8e-26 91.5 25.0 7.7e-21 74.5 13.4 2.3 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 EMC78369.1 - 4.1e-09 37.1 0.0 6.2e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EMC78369.1 - 0.00015 21.2 0.0 0.00022 20.7 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EMC78369.1 - 0.0012 18.7 0.0 0.002 18.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EMC78369.1 - 0.0036 16.5 10.4 0.0036 16.5 10.4 2.3 2 0 0 2 2 2 1 ABC-2 family transporter protein AAA_13 PF13166.6 EMC78369.1 - 0.043 12.5 0.0 0.059 12.0 0.0 1.1 1 0 0 1 1 1 0 AAA domain zf-C2H2 PF00096.26 EMC78370.1 - 7.2e-22 76.6 77.0 5.6e-05 23.4 5.8 9.3 9 0 0 9 9 9 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC78370.1 - 4.5e-18 64.4 72.4 6.8e-05 23.4 2.3 9.7 10 0 0 10 10 10 8 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC78370.1 - 1.9e-17 62.8 64.7 7.6e-06 26.1 3.3 9.1 10 0 0 10 10 9 6 Zinc-finger double domain zf-met PF12874.7 EMC78370.1 - 1.1e-06 28.8 28.6 0.21 12.0 0.1 6.5 5 0 0 5 5 5 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMC78370.1 - 1.2e-06 28.7 40.2 0.0065 16.7 0.5 7.4 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 EMC78370.1 - 0.00037 20.2 5.7 0.00037 20.2 5.7 8.4 8 1 0 8 8 8 3 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.6 EMC78370.1 - 0.00042 20.2 13.0 0.0055 16.7 1.1 6.4 7 0 0 7 7 7 3 C2H2-type zinc finger zf-Di19 PF05605.12 EMC78370.1 - 0.0026 18.0 7.5 0.0026 18.0 7.5 6.4 4 1 1 6 6 6 3 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.6 EMC78370.1 - 0.018 15.0 0.7 0.018 15.0 0.7 5.9 7 0 0 7 7 6 0 zinc-finger of a C2HC-type zf-Dof PF02701.15 EMC78370.1 - 0.025 14.7 0.6 0.025 14.7 0.6 3.7 4 0 0 4 4 3 0 Dof domain, zinc finger SLIDE PF09111.10 EMC78370.1 - 0.098 12.7 0.0 0.86 9.6 0.0 2.2 2 0 0 2 2 2 0 SLIDE zf-C2H2_2 PF12756.7 EMC78370.1 - 0.38 11.1 41.3 0.22 11.9 4.5 6.3 1 1 5 7 7 7 0 C2H2 type zinc-finger (2 copies) DUF5566 PF17721.1 EMC78371.1 - 2.3e-115 384.7 17.8 2.6e-115 384.6 17.8 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5566) Ank PF00023.30 EMC78373.1 - 7.3e-28 95.8 6.6 1.1e-07 32.0 0.3 6.5 6 0 0 6 6 6 4 Ankyrin repeat Ank_2 PF12796.7 EMC78373.1 - 2.8e-26 91.9 6.3 6.6e-12 45.8 0.5 3.6 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) PD-C2-AF1 PF09310.10 EMC78373.1 - 1.1e-24 87.2 0.3 2.2e-24 86.2 0.3 1.5 1 0 0 1 1 1 1 POU domain, class 2, associating factor 1 Ank_4 PF13637.6 EMC78373.1 - 4.4e-23 81.3 4.1 6.2e-06 26.7 0.0 5.5 2 1 3 6 6 6 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC78373.1 - 2.1e-21 75.7 2.9 1.5e-11 44.3 0.0 5.6 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC78373.1 - 6.3e-20 69.2 2.1 0.00059 20.1 0.0 6.6 7 0 0 7 7 7 4 Ankyrin repeat BTG PF07742.12 EMC78374.1 - 2e-43 146.9 0.1 2.9e-43 146.4 0.1 1.2 1 0 0 1 1 1 1 BTG family DUF5526 PF17664.1 EMC78375.1 - 4.3e-28 98.0 7.4 4.1e-18 65.5 5.8 2.0 2 0 0 2 2 2 2 Family of unknown function (DUF5526) Lectin_C PF00059.21 EMC78376.1 - 5e-17 62.6 0.2 1.2e-16 61.4 0.2 1.7 1 0 0 1 1 1 1 Lectin C-type domain Orf78 PF06024.12 EMC78376.1 - 0.074 13.4 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Orf78 (ac78) DUF3377 PF11857.8 EMC78376.1 - 0.08 12.9 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) TMEM154 PF15102.6 EMC78376.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.5 1 1 0 1 1 1 0 TMEM154 protein family Pkinase PF00069.25 EMC78377.1 - 3.6e-68 229.8 0.0 7.1e-68 228.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC78377.1 - 6.8e-36 123.9 0.0 1.1e-35 123.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC78377.1 - 3.8e-08 33.0 0.0 7.8e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EMC78377.1 - 0.00038 19.5 0.0 0.00038 19.5 0.0 2.5 3 0 0 3 3 3 1 Haspin like kinase domain SUKH-4 PF14435.6 EMC78377.1 - 0.021 14.9 0.6 0.13 12.4 0.6 2.3 1 1 0 1 1 1 0 SUKH-4 immunity protein Kdo PF06293.14 EMC78377.1 - 0.033 13.6 0.1 0.073 12.4 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2431 PF10354.9 EMC78378.1 - 5.5e-42 143.9 0.0 1.1e-41 142.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) FDX-ACB PF03147.14 EMC78378.1 - 2.6e-16 59.8 0.0 4.5e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain HSP20 PF00011.21 EMC78379.1 - 5.9e-27 93.8 0.1 7.3e-27 93.5 0.1 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Crystallin PF00525.18 EMC78379.1 - 5.5e-24 84.1 1.4 8.6e-24 83.5 1.4 1.3 1 0 0 1 1 1 1 Alpha crystallin A chain, N terminal ArsA_HSP20 PF17886.1 EMC78379.1 - 0.0036 16.8 0.0 0.0065 16.0 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA HSP20 PF00011.21 EMC78380.1 - 1.1e-19 70.5 0.0 1.7e-19 69.8 0.0 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Crystallin PF00525.18 EMC78380.1 - 5.1e-06 26.6 0.0 8.8e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Alpha crystallin A chain, N terminal DAO PF01266.24 EMC78381.1 - 2.8e-18 66.6 0.4 3.4e-18 66.3 0.4 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase SH3_2 PF07653.17 EMC78382.1 - 6.9e-13 48.1 0.0 9.1e-13 47.7 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC78382.1 - 3.9e-07 29.6 0.3 8.2e-07 28.5 0.3 1.6 1 1 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC78382.1 - 3.8e-06 26.7 0.1 5.7e-06 26.1 0.1 1.4 1 1 0 1 1 1 1 Variant SH3 domain VWA_N2 PF16164.5 EMC78382.1 - 0.00045 20.3 0.0 0.00059 19.9 0.0 1.2 1 0 0 1 1 1 1 VWA N-terminal Guanylate_kin PF00625.21 EMC78383.1 - 8.8e-41 139.6 0.0 9.9e-41 139.4 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase RsgA_GTPase PF03193.16 EMC78383.1 - 0.017 15.1 0.0 0.024 14.5 0.0 1.2 1 0 0 1 1 1 0 RsgA GTPase FYRN PF05964.14 EMC78384.1 - 0.054 13.3 7.7 5 7.0 0.4 3.9 2 1 1 3 3 3 0 F/Y-rich N-terminus DUF4087 PF13316.6 EMC78384.1 - 0.78 10.3 21.1 5.4 7.6 2.3 4.3 1 1 3 4 4 4 0 Protein of unknown function (DUF4087) Collagen PF01391.18 EMC78386.1 - 1.1e-13 50.7 32.0 1.6e-11 43.8 32.0 2.0 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) COLFI PF01410.18 EMC78387.1 - 2.5e-29 102.2 0.0 2.7e-29 102.1 0.0 1.0 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Homeodomain PF00046.29 EMC78388.1 - 2.9e-21 75.1 3.7 5e-21 74.3 3.7 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC78388.1 - 0.0012 18.6 0.1 0.0026 17.6 0.1 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 EMC78388.1 - 0.012 15.0 0.2 0.012 15.0 0.2 1.7 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez YdaS_antitoxin PF15943.5 EMC78388.1 - 0.022 14.6 0.1 0.058 13.3 0.1 1.7 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT DUF3385 PF11865.8 EMC78389.1 - 1e-06 28.8 13.8 18 5.2 0.4 7.3 1 1 9 10 10 10 10 Domain of unknown function (DUF3385) IBR PF01485.21 EMC78389.1 - 4.4 7.6 107.5 16 5.8 0.3 14.4 1 1 13 14 14 14 0 IBR domain, a half RING-finger domain MOZ_SAS PF01853.18 EMC78391.1 - 4.3e-86 287.2 1.4 6.6e-86 286.5 1.4 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EMC78391.1 - 2.8e-23 81.2 1.6 2.8e-23 81.2 1.6 2.3 3 0 0 3 3 3 1 MYST family zinc finger domain zf-C2HC PF01530.18 EMC78391.1 - 8.3e-14 51.5 6.0 8.3e-14 51.5 6.0 2.0 2 0 0 2 2 2 1 Zinc finger, C2HC type Acetyltransf_7 PF13508.7 EMC78391.1 - 0.029 14.8 0.0 0.064 13.7 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-met PF12874.7 EMC78391.1 - 0.036 14.5 0.4 0.1 13.0 0.4 1.8 1 0 0 1 1 1 0 Zinc-finger of C2H2 type Methyltransf_23 PF13489.6 EMC78392.1 - 6.5e-16 58.6 0.0 8.6e-16 58.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC78392.1 - 7.3e-15 55.5 0.0 1.4e-14 54.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC78392.1 - 1e-14 55.0 0.0 1.8e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC78392.1 - 8.6e-13 48.8 0.0 1.4e-12 48.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC78392.1 - 1.5e-09 37.9 0.0 2.2e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMC78392.1 - 1.9e-06 27.4 0.0 8.2e-06 25.3 0.0 1.8 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EMC78392.1 - 0.00074 19.1 0.0 0.0012 18.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_8 PF05148.15 EMC78392.1 - 0.0048 16.8 0.0 0.0073 16.2 0.0 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase CheR PF01739.18 EMC78392.1 - 0.021 14.3 0.0 0.45 10.0 0.0 2.2 1 1 0 2 2 2 0 CheR methyltransferase, SAM binding domain TPMT PF05724.11 EMC78392.1 - 0.098 12.3 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_24 PF13578.6 EMC78392.1 - 0.17 12.9 0.0 0.53 11.3 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain Peptidase_M2 PF01401.18 EMC78393.1 - 0 1785.0 17.3 9.4e-272 902.7 4.3 2.0 2 0 0 2 2 2 2 Angiotensin-converting enzyme Ku_PK_bind PF08785.11 EMC78393.1 - 0.063 13.4 0.2 1.8 8.7 0.1 2.5 2 0 0 2 2 2 0 Ku C terminal domain like LPMO_10 PF03067.15 EMC78393.1 - 0.14 12.8 0.6 5.6 7.6 0.0 3.0 3 1 0 3 3 3 0 Lytic polysaccharide mono-oxygenase, cellulose-degrading DDR PF08841.10 EMC78393.1 - 0.28 10.1 0.2 16 4.4 0.0 2.1 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Peptidase_M32 PF02074.15 EMC78393.1 - 1.8 7.3 14.2 0.3 9.8 0.1 4.5 6 0 0 6 6 6 0 Carboxypeptidase Taq (M32) metallopeptidase Ion_trans PF00520.31 EMC78394.1 - 3.9e-37 127.8 6.3 5.3e-37 127.4 6.3 1.2 1 0 0 1 1 1 1 Ion transport protein PAS_9 PF13426.7 EMC78394.1 - 1.7e-17 63.6 0.0 3.3e-17 62.6 0.0 1.5 1 0 0 1 1 1 1 PAS domain cNMP_binding PF00027.29 EMC78394.1 - 9.5e-13 48.0 0.0 2.1e-12 46.9 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 EMC78394.1 - 1e-11 44.6 0.1 1e-11 44.6 0.1 2.0 2 0 0 2 2 2 1 Ion channel PAS PF00989.25 EMC78394.1 - 6.5e-08 32.6 0.0 2.6e-07 30.6 0.0 2.0 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.12 EMC78394.1 - 7.1e-05 23.0 0.0 0.00015 22.0 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EMC78394.1 - 0.00075 19.5 0.0 0.0025 17.8 0.0 1.9 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 EMC78394.1 - 0.00076 19.7 0.0 0.025 14.8 0.0 2.9 3 0 0 3 3 3 1 PAS fold DegS PF05384.11 EMC78394.1 - 0.064 12.8 0.1 0.74 9.3 0.0 2.5 3 0 0 3 3 3 0 Sensor protein DegS PAN_3 PF08277.12 EMC78394.1 - 2.3 8.1 5.1 0.78 9.6 0.5 2.5 3 0 0 3 3 3 0 PAN-like domain WD40 PF00400.32 EMC78395.1 - 3.4e-06 27.7 9.2 0.032 15.1 1.0 4.6 5 0 0 5 5 5 3 WD domain, G-beta repeat Pkinase PF00069.25 EMC78396.1 - 6.7e-69 232.2 0.0 9.5e-69 231.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC78396.1 - 8.7e-41 139.9 0.0 1.3e-40 139.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.24 EMC78396.1 - 5.6e-12 45.4 0.1 1.4e-11 44.2 0.1 1.7 1 0 0 1 1 1 1 PB1 domain Kinase-like PF14531.6 EMC78396.1 - 3.2e-06 26.7 0.0 0.00026 20.4 0.0 2.4 1 1 1 2 2 2 2 Kinase-like FTA2 PF13095.6 EMC78396.1 - 0.078 12.6 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 LIM PF00412.22 EMC78397.1 - 5.4e-11 42.5 10.5 7.1e-11 42.2 10.5 1.2 1 0 0 1 1 1 1 LIM domain zf-SNAP50_C PF12251.8 EMC78397.1 - 0.11 12.2 6.6 0.12 12.0 6.6 1.2 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal zf-CCCH PF00642.24 EMC78399.1 - 4.8e-09 35.9 2.7 4.8e-09 35.9 2.7 1.9 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 EMC78399.1 - 1.1e-08 34.7 9.1 2.3e-08 33.8 9.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC78399.1 - 5.4e-08 32.5 10.2 1.1e-07 31.5 10.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC78399.1 - 4.3e-06 26.5 11.2 1e-05 25.3 11.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC78399.1 - 5.9e-06 26.1 12.9 1.2e-05 25.2 12.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EMC78399.1 - 1.1e-05 25.7 10.5 2.3e-05 24.6 10.5 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EMC78399.1 - 3.6e-05 23.7 9.9 8.4e-05 22.5 9.9 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf_CCCH_4 PF18345.1 EMC78399.1 - 5.1e-05 23.2 4.4 5.1e-05 23.2 4.4 2.0 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH_4 PF18044.1 EMC78399.1 - 0.00036 20.2 2.7 0.00036 20.2 2.7 2.6 2 0 0 2 2 2 1 CCCH-type zinc finger Prok-RING_4 PF14447.6 EMC78399.1 - 0.00052 19.8 7.9 0.00098 18.9 7.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EMC78399.1 - 0.0024 18.0 9.7 0.0024 18.0 9.7 1.8 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 EMC78399.1 - 0.0096 15.7 4.7 0.021 14.6 4.7 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.5 EMC78399.1 - 0.015 15.4 7.2 0.015 15.4 7.2 1.9 2 0 0 2 2 1 0 zinc RING finger of MSL2 Pannexin_like PF12534.8 EMC78399.1 - 0.058 12.5 0.2 0.058 12.5 0.2 1.4 2 0 0 2 2 1 0 Pannexin-like TM region of LRRC8 zf-P11 PF03854.14 EMC78399.1 - 0.12 12.1 7.7 0.21 11.2 7.7 1.4 1 0 0 1 1 1 0 P-11 zinc finger zf-CCCH_2 PF14608.6 EMC78399.1 - 1.1 9.9 7.7 0.097 13.2 2.5 2.0 2 0 0 2 2 1 0 RNA-binding, Nab2-type zinc finger zf-rbx1 PF12678.7 EMC78399.1 - 5.4 7.4 9.6 33 4.9 9.6 2.1 1 1 0 1 1 1 0 RING-H2 zinc finger domain Pkinase PF00069.25 EMC78400.1 - 1.4e-35 122.9 0.0 1.8e-35 122.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC78400.1 - 9.4e-24 84.1 0.0 1.5e-22 80.2 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase DUF1682 PF07946.14 EMC78401.1 - 1.4e-93 313.6 4.7 2e-93 313.2 4.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) Guanylate_kin PF00625.21 EMC78402.1 - 1.9e-41 141.7 0.4 3e-41 141.1 0.4 1.3 1 0 0 1 1 1 1 Guanylate kinase L27 PF02828.16 EMC78402.1 - 1.5e-24 85.5 4.4 5.9e-13 48.4 0.5 2.5 2 0 0 2 2 2 2 L27 domain PDZ PF00595.24 EMC78402.1 - 6.6e-12 45.6 0.8 1.5e-11 44.5 0.8 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC78402.1 - 7.3e-09 35.4 2.8 2.2e-08 33.8 0.3 2.8 3 0 0 3 3 3 1 PDZ domain PDZ_2 PF13180.6 EMC78402.1 - 2.6e-06 27.7 0.2 3.7e-05 24.0 0.1 2.5 2 0 0 2 2 2 1 PDZ domain SH3_2 PF07653.17 EMC78402.1 - 0.0031 17.2 0.0 0.0071 16.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC78402.1 - 0.011 15.3 0.0 0.024 14.3 0.0 1.5 1 0 0 1 1 1 0 SH3 domain UPF0449 PF15136.6 EMC78402.1 - 0.035 14.6 0.2 0.14 12.6 0.2 2.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 Ras PF00071.22 EMC78403.1 - 7.7e-48 162.2 0.0 9.4e-48 161.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC78403.1 - 1.4e-25 89.8 0.0 2.3e-25 89.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC78403.1 - 2.3e-12 46.7 0.0 2.8e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC78403.1 - 0.00077 19.0 0.0 0.0015 18.1 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF2891 PF11199.8 EMC78403.1 - 0.15 11.0 0.0 0.2 10.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2891) DSPc PF00782.20 EMC78404.1 - 4.3e-34 117.2 0.0 5.3e-34 116.9 0.0 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC78404.1 - 4.4e-05 23.2 0.0 5.3e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 EMC78404.1 - 0.0011 19.3 0.0 0.0014 18.9 0.0 1.2 1 0 0 1 1 1 1 Rit1 DUSP-like domain baeRF_family7 PF18849.1 EMC78404.1 - 0.021 15.0 0.1 0.028 14.6 0.1 1.1 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 7 DUF442 PF04273.13 EMC78404.1 - 0.025 14.7 0.0 0.049 13.7 0.0 1.7 1 1 0 1 1 1 0 Putative phosphatase (DUF442) PTPlike_phytase PF14566.6 EMC78404.1 - 0.026 14.6 0.0 0.032 14.3 0.0 1.1 1 0 0 1 1 1 0 Inositol hexakisphosphate Sclerostin PF05463.11 EMC78405.1 - 3.1e-76 255.5 4.5 3.4e-76 255.4 4.5 1.0 1 0 0 1 1 1 1 Sclerostin (SOST) DAN PF03045.15 EMC78405.1 - 6.4e-25 87.4 2.0 9.6e-25 86.8 2.0 1.3 1 0 0 1 1 1 1 DAN domain Cys_knot PF00007.22 EMC78405.1 - 1.5e-06 28.4 2.1 2.9e-06 27.5 2.1 1.5 1 0 0 1 1 1 1 Cystine-knot domain Homeodomain PF00046.29 EMC78406.1 - 5.2e-23 80.7 8.0 8.3e-23 80.0 8.0 1.3 1 0 0 1 1 1 1 Homeodomain Menin PF05053.13 EMC78406.1 - 0.026 12.9 0.9 0.031 12.7 0.9 1.0 1 0 0 1 1 1 0 Menin RNA_pol_Rpc4 PF05132.14 EMC78406.1 - 0.4 11.1 3.8 0.72 10.3 3.8 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 Presenilin PF01080.17 EMC78406.1 - 2.1 7.0 4.4 2.2 7.0 4.4 1.1 1 0 0 1 1 1 0 Presenilin ETS_PEA3_N PF04621.13 EMC78407.1 - 2.4e-75 254.6 18.3 1.3e-74 252.2 18.3 2.0 1 1 0 1 1 1 1 PEA3 subfamily ETS-domain transcription factor N terminal domain Ets PF00178.22 EMC78407.1 - 7.2e-39 132.1 0.1 1.3e-38 131.3 0.1 1.4 1 0 0 1 1 1 1 Ets-domain OB_NTP_bind PF07717.16 EMC78408.1 - 8.5e-26 90.1 0.0 1.7e-25 89.2 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EMC78408.1 - 1.2e-24 86.7 3.2 1.2e-24 86.7 0.1 2.5 2 0 0 2 2 2 1 Helicase associated domain (HA2) S1 PF00575.23 EMC78408.1 - 2e-14 53.6 0.1 4.5e-14 52.6 0.1 1.6 1 0 0 1 1 1 1 S1 RNA binding domain Helicase_C PF00271.31 EMC78408.1 - 1.5e-13 51.0 0.0 4.3e-13 49.6 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EMC78408.1 - 4e-06 26.7 0.3 1.2e-05 25.1 0.3 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EMC78408.1 - 0.00019 21.7 0.6 0.0013 19.0 0.6 2.4 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 EMC78408.1 - 0.0016 17.5 0.1 0.0035 16.4 0.1 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 EMC78408.1 - 0.0032 17.8 0.2 0.0071 16.7 0.2 1.6 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 EMC78408.1 - 0.019 14.9 0.1 0.044 13.8 0.1 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_30 PF13604.6 EMC78408.1 - 0.032 13.9 0.0 0.064 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EMC78408.1 - 0.063 13.7 0.0 0.2 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain PhoH PF02562.16 EMC78408.1 - 0.069 12.6 0.1 0.18 11.2 0.1 1.6 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 EMC78408.1 - 0.11 13.0 1.8 0.82 10.2 0.2 3.1 3 1 1 4 4 4 0 ABC transporter Sigma54_activ_2 PF14532.6 EMC78408.1 - 0.14 12.2 0.0 0.41 10.8 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain Transformer PF06495.11 EMC78408.1 - 2.9 7.9 30.3 6.9 6.7 30.3 1.6 1 0 0 1 1 1 0 Fruit fly transformer protein DUF1356 PF07092.12 EMC78409.1 - 4.8e-100 333.6 2.4 5.6e-100 333.4 2.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1356) Anti-TRAP PF15777.5 EMC78409.1 - 0.00083 19.3 0.2 0.0017 18.2 0.2 1.5 1 0 0 1 1 1 1 Tryptophan RNA-binding attenuator protein inhibitory protein ADH_zinc_N_2 PF13602.6 EMC78410.1 - 1.9e-21 77.5 0.0 3.3e-21 76.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EMC78410.1 - 9.9e-17 61.1 0.1 1.5e-16 60.5 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NID PF07292.13 EMC78413.1 - 5e-57 190.5 0.0 2e-28 98.9 0.0 2.1 2 0 0 2 2 2 2 Nmi/IFP 35 domain (NID) PHM7_cyt PF14703.6 EMC78413.1 - 0.042 14.1 0.0 5 7.3 0.0 2.9 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter Ribosomal_L27e PF01777.18 EMC78414.1 - 2e-39 133.8 8.8 2.3e-39 133.6 8.8 1.0 1 0 0 1 1 1 1 Ribosomal L27e protein family RUN PF02759.19 EMC78415.1 - 4.3e-35 120.6 0.1 7.7e-35 119.8 0.1 1.4 1 0 0 1 1 1 1 RUN domain FliD_C PF07195.12 EMC78415.1 - 1.2 8.5 3.7 7.1 6.0 2.7 2.2 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus CS PF04969.16 EMC78416.1 - 0.0015 19.5 0.0 0.002 19.1 0.0 1.2 1 0 0 1 1 1 1 CS domain Nod_GRP PF07806.11 EMC78416.1 - 0.024 14.5 2.2 0.045 13.6 2.2 1.4 1 0 0 1 1 1 0 Nodule-specific GRP repeat Phosphodiest PF01663.22 EMC78416.1 - 0.068 12.7 1.2 0.083 12.5 1.2 1.0 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase APG6 PF04111.12 EMC78417.1 - 1.1e-76 256.8 0.0 1.7e-76 256.1 0.0 1.3 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 EMC78417.1 - 1.7e-29 103.0 33.5 2.9e-29 102.3 33.5 1.4 1 0 0 1 1 1 1 Apg6 coiled-coil region BH3 PF15285.6 EMC78417.1 - 4e-14 52.0 0.2 8.5e-14 50.9 0.2 1.6 1 0 0 1 1 1 1 Beclin-1 BH3 domain, Bcl-2-interacting FapA PF03961.13 EMC78417.1 - 0.00098 17.8 8.0 0.0014 17.3 8.0 1.3 1 0 0 1 1 1 1 Flagellar Assembly Protein A IFT57 PF10498.9 EMC78417.1 - 0.022 13.8 16.5 0.037 13.0 16.5 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Exonuc_VII_L PF02601.15 EMC78417.1 - 0.033 13.7 4.3 0.048 13.2 4.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit LMBR1 PF04791.16 EMC78417.1 - 0.35 9.7 2.1 0.5 9.2 2.1 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein ERM PF00769.19 EMC78417.1 - 0.56 10.0 22.3 0.94 9.2 22.3 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family V_ATPase_I PF01496.19 EMC78417.1 - 0.66 7.8 9.3 0.88 7.4 9.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Jnk-SapK_ap_N PF09744.9 EMC78417.1 - 0.85 9.8 22.4 1.7 8.9 22.4 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 NAPRTase_C PF17956.1 EMC78417.1 - 1.3 9.4 5.7 0.34 11.3 1.0 2.4 3 0 0 3 3 3 0 Nicotinate phosphoribosyltransferase C-terminal domain TMPIT PF07851.13 EMC78417.1 - 2.1 7.5 11.1 3.6 6.7 11.1 1.3 1 0 0 1 1 1 0 TMPIT-like protein YabA PF06156.13 EMC78417.1 - 2.4 8.9 14.7 1.1 10.0 10.4 2.4 1 1 1 2 2 2 0 Initiation control protein YabA MT PF12777.7 EMC78417.1 - 3.1 6.7 8.8 5.6 5.9 8.8 1.4 1 0 0 1 1 1 0 Microtubule-binding stalk of dynein motor UPF0242 PF06785.11 EMC78417.1 - 4.7 7.3 20.4 8.5 6.4 20.4 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4200 PF13863.6 EMC78417.1 - 6.2 7.3 28.2 1.8 9.0 22.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) GAS PF13851.6 EMC78417.1 - 6.6 6.0 26.8 0.26 10.6 10.6 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Cyclin_N PF00134.23 EMC78418.1 - 1.2e-09 38.0 1.1 0.00035 20.3 0.1 2.5 3 0 0 3 3 3 2 Cyclin, N-terminal domain ESCRT-II PF05871.12 EMC78419.1 - 6.1e-28 97.8 0.1 8.9e-28 97.3 0.1 1.2 1 0 0 1 1 1 1 ESCRT-II complex subunit LisH_TPL PF17814.1 EMC78419.1 - 0.026 14.2 0.5 5.4 6.8 0.5 2.3 2 0 0 2 2 2 0 LisH-like dimerisation domain RAMP PF04901.13 EMC78420.1 - 5.3e-39 132.6 0.9 5.9e-39 132.5 0.9 1.0 1 0 0 1 1 1 1 Receptor activity modifying family 7tm_1 PF00001.21 EMC78421.1 - 1.7e-37 129.2 1.2 2.1e-37 128.9 1.2 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC78421.1 - 1.4e-05 24.6 0.2 1.7e-05 24.4 0.2 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx V1R PF03402.14 EMC78421.1 - 0.14 11.8 1.7 0.11 12.0 0.5 1.5 2 0 0 2 2 2 0 Vomeronasal organ pheromone receptor family, V1R Tubulin PF00091.25 EMC78422.1 - 1.1e-50 172.6 0.0 1.8e-50 171.9 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EMC78422.1 - 8.1e-47 158.5 0.1 1.7e-46 157.5 0.1 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EMC78422.1 - 0.023 14.4 0.2 0.056 13.1 0.0 1.7 2 0 0 2 2 2 0 Tubulin domain Tubulin_2 PF13809.6 EMC78422.1 - 0.046 12.9 0.0 0.077 12.2 0.0 1.4 1 0 0 1 1 1 0 Tubulin like DUF4131 PF13567.6 EMC78423.1 - 0.046 13.4 0.2 0.046 13.4 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) LZ3wCH PF18517.1 EMC78424.1 - 3.4e-14 52.7 1.2 3.2e-13 49.6 0.1 2.2 2 0 0 2 2 2 1 Leucine zipper with capping helix domain NPA PF16469.5 EMC78424.1 - 0.015 15.9 3.3 0.017 15.7 2.9 1.3 1 1 0 1 1 1 0 Nematode polyprotein allergen ABA-1 FlxA PF14282.6 EMC78424.1 - 0.2 11.7 0.1 0.29 11.2 0.1 1.3 1 0 0 1 1 1 0 FlxA-like protein CCDC-167 PF15188.6 EMC78424.1 - 0.22 11.9 3.2 0.38 11.1 3.2 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 HLH PF00010.26 EMC78425.1 - 8.2e-15 54.5 0.1 2.3e-14 53.1 0.1 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF3322 PF11795.8 EMC78425.1 - 0.048 13.7 0.5 0.12 12.3 0.2 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) CoaE PF01121.20 EMC78426.1 - 5.3e-47 159.8 0.0 6.6e-47 159.5 0.0 1.0 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_33 PF13671.6 EMC78426.1 - 1.3e-06 28.6 0.2 6.7e-06 26.3 0.2 2.0 1 1 0 1 1 1 1 AAA domain Cytidylate_kin2 PF13189.6 EMC78426.1 - 0.00087 19.5 0.4 0.0022 18.1 0.4 1.6 1 1 0 1 1 1 1 Cytidylate kinase-like family AAA_18 PF13238.6 EMC78426.1 - 0.0046 17.5 0.8 0.0091 16.5 0.1 1.9 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EMC78426.1 - 0.0078 15.5 0.6 0.043 13.1 0.0 2.0 2 0 0 2 2 2 1 Zeta toxin AAA_28 PF13521.6 EMC78426.1 - 0.0094 16.2 4.7 0.086 13.1 1.9 2.6 1 1 1 2 2 2 1 AAA domain KAP_NTPase PF07693.14 EMC78426.1 - 0.017 14.4 0.0 0.033 13.4 0.0 1.4 1 0 0 1 1 1 0 KAP family P-loop domain ANTAR PF03861.14 EMC78426.1 - 0.036 13.9 0.8 0.068 13.0 0.8 1.5 1 0 0 1 1 1 0 ANTAR domain Pox_A32 PF04665.12 EMC78426.1 - 0.041 13.4 0.0 1.8 8.0 0.1 2.1 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_24 PF13479.6 EMC78426.1 - 0.084 12.6 0.3 0.12 12.1 0.2 1.5 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EMC78426.1 - 0.1 13.1 0.4 0.21 12.1 0.1 1.6 2 1 0 2 2 2 0 ABC transporter adh_short PF00106.25 EMC78427.1 - 7.6e-28 97.3 0.0 1e-27 96.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC78427.1 - 1.1e-20 74.2 0.0 1.5e-20 73.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 EMC78427.1 - 1.6e-05 24.5 0.0 2e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) KR PF08659.10 EMC78427.1 - 0.18 11.7 0.0 0.25 11.2 0.0 1.2 1 0 0 1 1 1 0 KR domain rOmpB PF12334.8 EMC78427.1 - 0.23 10.9 0.0 0.32 10.4 0.0 1.1 1 0 0 1 1 1 0 Rickettsia outer membrane protein B V_ATPase_I PF01496.19 EMC78428.1 - 0 1131.5 0.0 0 1131.4 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family PTRF_SDPR PF15237.6 EMC78429.1 - 6.7e-103 343.6 37.0 2.5e-100 335.1 37.0 2.1 1 1 0 1 1 1 1 PTRF/SDPR family pP_pnuc_2 PF18166.1 EMC78429.1 - 0.0092 16.0 0.9 0.11 12.6 0.0 2.7 2 0 0 2 2 2 1 Predicted pPIWI-associating nuclease DUF1664 PF07889.12 EMC78429.1 - 0.02 14.9 7.8 0.02 14.9 7.8 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) HrpB7 PF09486.10 EMC78429.1 - 0.2 12.0 8.0 0.037 14.4 3.0 2.2 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) Baculo_PEP_C PF04513.12 EMC78429.1 - 0.49 10.4 12.3 0.46 10.5 6.6 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF16 PF01519.16 EMC78429.1 - 0.5 10.9 20.3 0.24 11.9 7.5 2.8 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF948 PF06103.11 EMC78429.1 - 1.8 8.9 14.1 0.13 12.5 6.8 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) FlaC_arch PF05377.11 EMC78429.1 - 4.4 7.8 19.2 2.5 8.6 2.7 4.0 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Fib_alpha PF08702.10 EMC78429.1 - 6.1 7.0 22.0 0.93 9.7 5.9 2.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family STAT_alpha PF01017.20 EMC78430.1 - 1.3e-53 181.4 16.2 2.7e-53 180.4 16.2 1.5 1 0 0 1 1 1 1 STAT protein, all-alpha domain STAT_bind PF02864.15 EMC78430.1 - 4.6e-38 130.8 1.9 8.8e-38 129.9 0.0 2.2 2 0 0 2 2 2 1 STAT protein, DNA binding domain STAT_int PF02865.17 EMC78430.1 - 5.1e-38 130.3 7.9 5.1e-38 130.3 7.9 3.2 3 1 1 4 4 4 1 STAT protein, protein interaction domain SH2 PF00017.24 EMC78430.1 - 3.2e-14 52.8 0.0 8.6e-14 51.4 0.0 1.8 1 0 0 1 1 1 1 SH2 domain Syntaxin-6_N PF09177.11 EMC78430.1 - 0.18 12.4 4.7 0.18 12.4 1.3 2.6 2 1 1 3 3 3 0 Syntaxin 6, N-terminal YojJ PF10372.9 EMC78430.1 - 0.25 11.4 6.7 1.6 8.9 0.3 2.8 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus Fib_alpha PF08702.10 EMC78430.1 - 0.29 11.3 10.3 0.27 11.4 5.3 2.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Tropomyosin_1 PF12718.7 EMC78430.1 - 0.63 10.2 8.3 0.094 12.9 3.1 2.0 2 0 0 2 2 2 0 Tropomyosin like RecG_N PF17190.4 EMC78430.1 - 1 10.1 10.1 2.1 9.2 0.2 3.8 3 1 0 3 3 3 0 RecG N-terminal helical domain MerR-DNA-bind PF09278.11 EMC78430.1 - 2.9 8.5 13.7 3.6 8.2 0.6 3.9 4 0 0 4 4 4 0 MerR, DNA binding Cep57_CLD PF14073.6 EMC78430.1 - 3.4 7.6 16.2 6.2 6.8 4.5 3.1 2 1 0 3 3 3 0 Centrosome localisation domain of Cep57 PRKG1_interact PF15898.5 EMC78430.1 - 3.5 8.6 11.3 0.95 10.4 5.2 2.6 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain eIF3_N PF09440.10 EMC78430.1 - 3.8 8.0 11.8 2.7 8.5 2.7 3.1 2 1 1 3 3 3 0 eIF3 subunit 6 N terminal domain Ras PF00071.22 EMC78432.1 - 1.6e-61 206.6 0.5 1.9e-61 206.4 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC78432.1 - 2e-35 121.6 0.0 3.5e-35 120.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC78432.1 - 5.1e-12 45.6 0.1 6.4e-12 45.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EMC78432.1 - 0.0001 21.7 0.0 0.00013 21.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMC78432.1 - 0.00017 21.6 0.0 0.00027 21.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC78432.1 - 0.001 19.0 0.4 0.37 10.7 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EMC78432.1 - 0.0034 16.9 0.2 0.01 15.4 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EMC78432.1 - 0.028 14.8 0.1 0.043 14.2 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain SRPRB PF09439.10 EMC78432.1 - 0.1 12.0 0.1 0.33 10.4 0.0 1.8 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit BrnT_toxin PF04365.13 EMC78432.1 - 0.15 12.4 0.1 0.97 9.8 0.0 2.0 2 0 0 2 2 2 0 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system HSP20 PF00011.21 EMC78433.1 - 6.2e-16 58.4 0.0 9e-16 57.9 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family HSP20 PF00011.21 EMC78434.1 - 3.4e-14 52.8 0.0 5e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family RIG-I_C PF18119.1 EMC78435.1 - 9e-40 135.9 3.2 3.2e-39 134.1 2.5 2.2 2 0 0 2 2 2 1 RIG-I receptor C-terminal domain RIG-I_C-RD PF11648.8 EMC78435.1 - 1.1e-37 128.8 0.9 1.1e-37 128.8 0.9 1.9 2 0 0 2 2 2 1 C-terminal domain of RIG-I Helicase_C PF00271.31 EMC78435.1 - 4.9e-20 71.9 0.4 6.9e-18 65.0 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC78435.1 - 1.6e-19 70.6 0.0 3.2e-19 69.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EMC78435.1 - 7.3e-19 68.2 0.0 2.4e-18 66.5 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EMC78435.1 - 2.3e-07 30.7 0.1 4.4e-07 29.8 0.1 1.4 1 0 0 1 1 1 1 SWI2/SNF2 ATPase AAA_11 PF13086.6 EMC78435.1 - 5.6e-05 23.1 4.5 0.024 14.5 0.8 3.0 2 1 1 3 3 3 2 AAA domain AAA_19 PF13245.6 EMC78435.1 - 0.00047 20.5 1.0 0.18 12.1 0.1 3.0 1 1 1 2 2 2 2 AAA domain SNF2_N PF00176.23 EMC78435.1 - 0.0056 15.4 0.1 0.012 14.4 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain AAA_22 PF13401.6 EMC78435.1 - 0.038 14.3 2.3 0.1 12.9 0.1 2.8 3 0 0 3 3 3 0 AAA domain AlaDh_PNT_C PF01262.21 EMC78435.1 - 0.08 12.2 0.1 0.19 11.0 0.1 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain zf-met PF12874.7 EMC78436.1 - 8.8e-08 32.3 0.5 8.8e-08 32.3 0.5 2.0 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMC78436.1 - 0.00031 20.9 0.6 0.00031 20.9 0.6 1.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding Pih1_fungal_CS PF18482.1 EMC78436.1 - 0.32 11.6 0.4 0.52 10.9 0.4 1.3 1 0 0 1 1 1 0 Fungal Pih1 CS domain TRAM_LAG1_CLN8 PF03798.16 EMC78437.1 - 1.4e-16 60.8 10.6 1.4e-16 60.8 10.6 2.3 2 0 0 2 2 2 1 TLC domain Homeodomain PF00046.29 EMC78437.1 - 2.4e-07 30.5 0.2 4.8e-07 29.5 0.2 1.5 1 0 0 1 1 1 1 Homeodomain TRAM1 PF08390.11 EMC78437.1 - 0.0097 15.5 0.3 0.026 14.2 0.3 1.7 1 0 0 1 1 1 1 TRAM1-like protein YdaS_antitoxin PF15943.5 EMC78437.1 - 0.068 13.1 0.1 0.22 11.4 0.0 1.8 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Toxin_25 PF08095.11 EMC78438.1 - 0.0075 16.2 48.3 20 5.2 0.2 10.0 10 0 0 10 10 10 9 Hefutoxin family DUF4639 PF15479.6 EMC78438.1 - 1.7 7.5 8.9 3 6.7 8.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4639) Aldedh PF00171.22 EMC78439.1 - 5.4e-184 612.0 0.0 6.1e-184 611.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EMC78439.1 - 0.0069 15.9 0.1 1.8 7.9 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1487) Pkinase PF00069.25 EMC78440.1 - 8.2e-39 133.6 0.0 3.5e-38 131.5 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC78440.1 - 1.4e-36 126.1 0.0 2.8e-36 125.1 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase LRR_8 PF13855.6 EMC78440.1 - 8.9e-27 92.6 21.7 3.3e-07 30.0 2.2 6.3 6 0 0 6 6 6 5 Leucine rich repeat COR PF16095.5 EMC78440.1 - 2.8e-24 86.0 0.1 5.5e-24 85.0 0.1 1.5 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain LRR_4 PF12799.7 EMC78440.1 - 1.6e-22 79.2 31.5 3.9e-06 27.1 1.5 8.1 6 2 2 8 8 8 7 Leucine Rich repeats (2 copies) Roc PF08477.13 EMC78440.1 - 1.9e-22 79.7 0.0 7.3e-22 77.8 0.0 2.1 2 0 0 2 2 1 1 Ras of Complex, Roc, domain of DAPkinase Ank_2 PF12796.7 EMC78440.1 - 3.2e-13 50.1 0.1 1.6e-05 25.4 0.1 2.8 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC78440.1 - 7.6e-07 29.6 0.2 0.0067 17.0 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC78440.1 - 1.3e-06 28.3 1.1 0.33 11.7 0.0 5.0 4 0 0 4 4 4 1 Ankyrin repeat Ras PF00071.22 EMC78440.1 - 1.9e-06 27.6 0.0 3.7e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Ras family Arf PF00025.21 EMC78440.1 - 9.4e-06 25.2 0.0 2.1e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family Ank_5 PF13857.6 EMC78440.1 - 0.00031 21.0 3.0 2.3 8.6 0.0 4.5 1 1 3 4 4 4 1 Ankyrin repeats (many copies) LRR_1 PF00560.33 EMC78440.1 - 0.00042 20.5 22.2 12 6.9 0.0 9.8 8 1 1 9 9 9 0 Leucine Rich Repeat Ank PF00023.30 EMC78440.1 - 0.00073 19.9 0.5 1.8 9.1 0.0 3.9 3 1 0 3 3 3 1 Ankyrin repeat TniB PF05621.11 EMC78440.1 - 0.11 11.9 0.2 0.32 10.4 0.1 1.7 2 0 0 2 2 2 0 Bacterial TniB protein MMR_HSR1 PF01926.23 EMC78440.1 - 0.18 11.9 0.0 0.42 10.7 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase LRR_6 PF13516.6 EMC78440.1 - 6.1 7.2 25.7 2.5 8.4 0.3 8.1 8 0 0 8 8 8 0 Leucine Rich repeat CHGN PF05679.16 EMC78441.1 - 5e-21 75.1 0.4 5.9e-21 74.9 0.4 1.1 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Fringe PF02434.16 EMC78441.1 - 2.9e-14 53.1 0.0 3.5e-14 52.9 0.0 1.1 1 0 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 EMC78441.1 - 3.6e-05 23.7 0.1 0.00028 20.8 0.1 1.9 1 1 0 1 1 1 1 Galactosyltransferase Glyco_transf_21 PF13506.6 EMC78441.1 - 0.0067 15.9 0.1 0.022 14.2 0.0 1.8 1 1 1 2 2 2 1 Glycosyl transferase family 21 Selenoprotein_S PF06936.11 EMC78442.1 - 1.8e-63 213.9 8.6 2e-63 213.7 8.6 1.0 1 0 0 1 1 1 1 Selenoprotein S (SelS) Trp_oprn_chp PF09534.10 EMC78442.1 - 0.39 10.5 2.1 0.61 9.9 2.1 1.2 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) LRR_9 PF14580.6 EMC78443.1 - 1.5e-78 262.2 1.1 1.9e-78 261.9 1.1 1.1 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EMC78443.1 - 2.9e-08 33.9 6.0 0.00035 20.9 1.6 2.6 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMC78443.1 - 2.8e-06 27.0 3.4 1.5e-05 24.6 2.7 2.3 1 1 1 2 2 2 2 Leucine rich repeat Peptidase_S8 PF00082.22 EMC78444.1 - 5e-49 167.2 0.2 7.4e-49 166.6 0.2 1.3 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 EMC78444.1 - 3e-32 110.5 0.1 4.9e-32 109.8 0.1 1.4 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 EMC78444.1 - 5.3e-14 52.7 1.0 1.1e-13 51.7 1.0 1.6 1 0 0 1 1 1 1 Peptidase S8 pro-domain GF_recep_IV PF14843.6 EMC78444.1 - 1.8e-13 50.4 55.5 6.9e-10 38.8 34.4 4.0 1 1 3 4 4 4 3 Growth factor receptor domain IV Furin-like_2 PF15913.5 EMC78444.1 - 2e-11 44.0 62.3 3.2e-05 24.0 14.6 4.1 2 2 1 3 3 3 3 Furin-like repeat, cysteine-rich PLAC PF08686.11 EMC78444.1 - 1.5e-06 28.8 10.1 1.5e-06 28.8 10.1 3.2 2 0 0 2 2 2 1 PLAC (protease and lacunin) domain VSP PF03302.13 EMC78444.1 - 0.51 9.1 57.4 0.052 12.4 10.6 3.9 1 1 3 4 4 4 0 Giardia variant-specific surface protein PH PF00169.29 EMC78445.1 - 2.5e-12 47.2 0.7 4e-12 46.6 0.7 1.3 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 EMC78445.1 - 0.00021 21.7 0.3 0.019 15.3 0.3 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EMC78445.1 - 0.0013 19.2 0.5 0.0042 17.5 0.5 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain CAP-ZIP_m PF15255.6 EMC78445.1 - 0.0036 17.6 0.0 0.0057 16.9 0.0 1.4 1 0 0 1 1 1 1 WASH complex subunit CAP-Z interacting, central region Mcp5_PH PF12814.7 EMC78445.1 - 0.037 14.1 0.0 0.053 13.6 0.0 1.4 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology Sep15_SelM PF08806.11 EMC78445.1 - 0.068 13.3 0.7 0.37 11.0 0.1 2.1 2 0 0 2 2 2 0 Sep15/SelM redox domain Herpes_U26 PF07402.11 EMC78445.1 - 0.31 10.6 0.0 0.41 10.2 0.0 1.1 1 0 0 1 1 1 0 Human herpesvirus U26 protein Ank_4 PF13637.6 EMC78446.1 - 3.9e-19 68.8 2.1 5.4e-10 39.6 0.2 3.1 1 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC78446.1 - 1.8e-18 66.9 0.4 8.4e-15 55.1 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC78446.1 - 5.5e-15 55.2 3.4 2.4e-06 27.7 0.2 4.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC78446.1 - 8.7e-13 47.2 0.8 0.00017 21.8 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 EMC78446.1 - 9.4e-10 38.5 0.2 0.039 14.4 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Collagen PF01391.18 EMC78447.1 - 7.5e-41 137.7 213.1 1.2e-06 28.1 28.8 8.0 1 1 4 5 5 5 4 Collagen triple helix repeat (20 copies) VWA PF00092.28 EMC78447.1 - 6.7e-26 91.6 1.5 9e-26 91.2 1.5 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EMC78447.1 - 8.3e-11 42.5 0.1 1.4e-10 41.8 0.1 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EMC78447.1 - 0.0099 15.8 0.1 0.027 14.4 0.1 1.7 1 1 0 1 1 1 1 von Willebrand factor type A domain RasGEF_N_2 PF14663.6 EMC78447.1 - 0.08 13.3 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain zinc_ribbon_16 PF17034.5 EMC78448.1 - 6.8e-24 84.5 14.3 1.5e-23 83.3 14.3 1.6 1 0 0 1 1 1 1 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 EMC78448.1 - 0.011 15.4 10.8 0.011 15.4 10.8 2.7 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type CheB_methylest PF01339.17 EMC78448.1 - 0.15 11.8 0.0 0.29 10.8 0.0 1.4 1 0 0 1 1 1 0 CheB methylesterase Rep_fac-A_3 PF08661.11 EMC78449.1 - 3e-19 69.3 0.0 3.3e-19 69.2 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 DUF2464 PF10240.9 EMC78450.1 - 0.026 14.1 0.0 0.028 14.0 0.0 1.0 1 0 0 1 1 1 0 Multivesicular body subunit 12 FAM117 PF15388.6 EMC78451.1 - 1e-121 406.2 19.9 1e-121 406.2 19.9 1.8 2 0 0 2 2 2 1 Protein Family FAM117 Csm1_N PF18504.1 EMC78451.1 - 2.1 8.7 6.1 0.61 10.5 1.9 2.1 2 0 0 2 2 2 0 Csm1 N-terminal domain FlxA PF14282.6 EMC78451.1 - 9.2 6.3 20.8 0.75 9.8 6.2 2.5 2 0 0 2 2 2 0 FlxA-like protein Neurexophilin PF06312.12 EMC78452.1 - 1.4e-111 371.0 2.7 1.8e-111 370.6 2.7 1.1 1 0 0 1 1 1 1 Neurexophilin NigD_C PF17415.2 EMC78452.1 - 0.048 13.7 0.1 0.8 9.8 0.0 2.2 2 0 0 2 2 2 0 NigD-like C-terminal beta sandwich domain Filamin PF00630.19 EMC78452.1 - 0.08 13.8 0.0 0.28 12.0 0.0 1.9 2 0 0 2 2 2 0 Filamin/ABP280 repeat B12D PF06522.11 EMC78453.1 - 1.2e-30 105.1 0.0 1.3e-30 104.9 0.0 1.0 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit Keratin PF02422.16 EMC78454.1 - 1.1e-21 76.4 15.3 3.7e-21 74.6 15.3 1.7 1 1 0 1 1 1 1 Keratin DUF3432 PF11914.8 EMC78454.1 - 0.089 13.1 5.5 0.11 12.8 5.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3432) Keratin PF02422.16 EMC78455.1 - 2.4e-30 104.1 13.6 2.9e-30 103.8 13.6 1.1 1 0 0 1 1 1 1 Keratin Cornifin PF02389.15 EMC78455.1 - 0.0082 16.3 2.3 0.01 16.1 2.3 1.1 1 0 0 1 1 1 1 Cornifin (SPRR) family zf-Tim10_DDP PF02953.15 EMC78455.1 - 0.054 13.1 0.0 0.092 12.4 0.0 1.4 1 0 0 1 1 1 0 Tim10/DDP family zinc finger DUF3432 PF11914.8 EMC78455.1 - 0.059 13.6 10.3 0.082 13.2 10.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3432) Keratin PF02422.16 EMC78456.1 - 6.5e-33 112.3 15.7 7.1e-33 112.2 15.7 1.0 1 0 0 1 1 1 1 Keratin DUF3432 PF11914.8 EMC78456.1 - 0.67 10.2 10.6 1.4 9.2 10.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3432) Keratin PF02422.16 EMC78457.1 - 2.2e-29 101.0 14.4 2.7e-29 100.7 14.4 1.1 1 0 0 1 1 1 1 Keratin DUF3432 PF11914.8 EMC78457.1 - 0.25 11.6 5.3 0.46 10.8 5.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3432) Pyridoxal_deC PF00282.19 EMC78458.1 - 1.8e-114 382.4 0.0 2.1e-114 382.2 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EMC78458.1 - 1.1e-06 27.8 0.0 6.9e-06 25.2 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EMC78458.1 - 5.3e-05 22.6 0.0 7.2e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase SepSecS PF05889.13 EMC78458.1 - 0.1 11.3 0.0 0.17 10.5 0.0 1.3 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS PSP1 PF04468.12 EMC78459.1 - 0.028 14.7 0.9 0.051 13.9 0.1 1.8 2 0 0 2 2 2 0 PSP1 C-terminal conserved region STT3 PF02516.14 EMC78460.1 - 4.6e-136 454.6 24.3 5.7e-136 454.3 24.3 1.1 1 0 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit Oxysterol_BP PF01237.18 EMC78461.1 - 2.9e-84 283.1 3.5 2.3e-82 276.8 3.5 2.3 1 1 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.6 EMC78461.1 - 2.4e-08 34.1 0.0 4.8e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EMC78461.1 - 2.6e-07 31.1 0.0 7.8e-07 29.6 0.0 1.8 1 0 0 1 1 1 1 PH domain PH_6 PF15406.6 EMC78461.1 - 0.012 15.9 0.0 0.045 14.0 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain NAD_Gly3P_dh_N PF01210.23 EMC78462.1 - 1.1e-45 155.4 0.2 1.4e-45 155.1 0.2 1.1 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.17 EMC78462.1 - 0.077 13.6 0.1 0.24 12.0 0.1 2.0 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent AcetDehyd-dimer PF09290.11 EMC78462.1 - 0.16 12.1 0.0 0.31 11.3 0.0 1.4 1 1 0 1 1 1 0 Prokaryotic acetaldehyde dehydrogenase, dimerisation MARVEL PF01284.23 EMC78463.1 - 1.4e-14 54.4 18.7 1.6e-14 54.2 18.7 1.0 1 0 0 1 1 1 1 Membrane-associating domain DUF5367 PF17329.2 EMC78463.1 - 0.06 13.5 7.7 0.09 12.9 7.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5367) TMEM138 PF14935.6 EMC78463.1 - 0.16 12.6 9.8 0.68 10.6 2.5 2.1 1 1 1 2 2 2 0 Transmembrane protein 138 Retrotran_gag_3 PF14244.6 EMC78463.1 - 0.21 11.4 1.0 0.25 11.2 0.1 1.6 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type HRG PF16954.5 EMC78463.1 - 5.5 7.5 21.1 0.38 11.2 7.4 3.1 2 1 1 3 3 3 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene AKAP2_C PF15304.6 EMC78464.1 - 3.8e-16 59.3 11.8 3.8e-16 59.3 11.8 2.9 2 1 0 2 2 2 1 A-kinase anchor protein 2 C-terminus Misat_Tub_SegII PF10644.9 EMC78464.1 - 0.037 14.3 0.3 0.21 11.9 0.1 2.5 2 0 0 2 2 2 0 Misato Segment II tubulin-like domain PX PF00787.24 EMC78465.1 - 8.2e-24 83.8 1.8 1.6e-23 82.8 1.8 1.5 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 EMC78465.1 - 2.6e-09 37.0 2.2 7.4e-05 22.4 0.0 2.5 2 1 1 3 3 3 2 Vps5 C terminal like BAR PF03114.18 EMC78465.1 - 5.3e-08 32.8 0.2 1.1e-07 31.7 0.2 1.6 1 0 0 1 1 1 1 BAR domain BAR_3_WASP_bdg PF10456.9 EMC78465.1 - 0.0044 16.5 0.3 0.0088 15.5 0.1 1.6 2 0 0 2 2 2 1 WASP-binding domain of Sorting nexin protein SOSSC PF15925.5 EMC78466.1 - 6.7e-23 81.9 0.8 4.5e-22 79.3 0.8 1.9 1 1 0 1 1 1 1 SOSS complex subunit C adh_short PF00106.25 EMC78468.1 - 2.9e-34 118.2 0.6 5.4e-34 117.4 0.6 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC78468.1 - 9.4e-28 97.3 0.9 1.8e-27 96.4 0.9 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase SCP2 PF02036.17 EMC78468.1 - 6.9e-23 81.1 0.0 1.4e-22 80.0 0.0 1.5 1 0 0 1 1 1 1 SCP-2 sterol transfer family KR PF08659.10 EMC78468.1 - 0.0002 21.3 1.8 0.00024 21.1 0.5 1.7 2 0 0 2 2 2 1 KR domain Alkyl_sulf_C PF14864.6 EMC78468.1 - 0.00081 19.7 0.0 0.0017 18.6 0.0 1.5 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal RRM_5 PF13893.6 EMC78469.1 - 7e-46 154.9 0.0 7.2e-36 122.5 0.0 3.6 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 EMC78469.1 - 5.1e-25 87.1 0.0 2.7e-08 33.5 0.0 4.4 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMC78469.1 - 5e-05 23.1 0.1 0.19 11.6 0.0 3.1 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_8 PF11835.8 EMC78469.1 - 0.00045 20.4 0.0 0.012 15.8 0.0 2.4 2 0 0 2 2 2 1 RRM-like domain RVT_1 PF00078.27 EMC78470.1 - 0.076 12.5 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) EGF_CA PF07645.15 EMC78471.1 - 8.8e-17 61.0 46.3 1.2e-09 38.2 7.3 4.5 4 0 0 4 4 4 2 Calcium-binding EGF domain EGF_3 PF12947.7 EMC78471.1 - 9.6e-13 48.1 41.6 2.8e-05 24.2 8.3 4.7 4 0 0 4 4 4 3 EGF domain cEGF PF12662.7 EMC78471.1 - 7.7e-12 44.9 25.4 1.4e-07 31.3 2.4 4.4 4 0 0 4 4 4 3 Complement Clr-like EGF-like Sushi PF00084.20 EMC78471.1 - 1.6e-11 44.6 29.0 4.9e-07 30.3 0.8 5.5 5 0 0 5 5 5 2 Sushi repeat (SCR repeat) EGF_MSP1_1 PF12946.7 EMC78471.1 - 7.1e-08 32.4 29.7 4.7e-05 23.4 7.6 3.9 3 0 0 3 3 3 3 MSP1 EGF domain 1 hEGF PF12661.7 EMC78471.1 - 3.6e-05 24.2 41.3 0.0015 19.1 7.7 5.1 4 0 0 4 4 4 3 Human growth factor-like EGF FXa_inhibition PF14670.6 EMC78471.1 - 4.3e-05 23.7 34.1 0.0021 18.3 6.2 4.4 3 1 1 4 4 4 2 Coagulation Factor Xa inhibitory site DUF4165 PF13752.6 EMC78471.1 - 0.024 14.6 3.1 1.3 9.1 0.5 3.2 3 1 1 4 4 4 0 Domain of unknown function (DUF4165) Cas_DxTHG PF09455.10 EMC78471.1 - 0.06 12.9 0.1 0.1 12.2 0.1 1.3 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family fn3 PF00041.21 EMC78471.1 - 0.11 12.9 0.0 16 5.9 0.0 3.2 3 0 0 3 3 3 0 Fibronectin type III domain TMEM190 PF15431.6 EMC78471.1 - 3.2 7.9 8.7 0.071 13.3 0.8 2.3 2 0 0 2 2 2 0 Transmembrane protein 190 G-gamma PF00631.22 EMC78472.1 - 2e-16 59.8 0.0 2.2e-16 59.6 0.0 1.0 1 0 0 1 1 1 1 GGL domain L31 PF09784.9 EMC78473.1 - 0.04 14.4 1.8 0.12 12.8 1.8 1.8 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L31 DUF2917 PF11142.8 EMC78474.1 - 0.00047 19.5 1.2 5.7 6.4 0.0 3.2 3 0 0 3 3 3 3 Protein of unknown function (DUF2917) DUF2875 PF11394.8 EMC78474.1 - 0.029 13.3 0.0 8.3 5.1 0.0 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF2875) AGH PF17558.2 EMC78474.1 - 0.05 13.8 0.0 5 7.3 0.0 2.0 1 1 1 2 2 2 0 Androgenic gland hormone DUF3984 PF13136.6 EMC78474.1 - 0.07 12.5 0.0 1.1 8.6 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3984) Vault PF01505.18 EMC78474.1 - 0.14 12.3 1.2 31 4.8 0.0 2.9 3 0 0 3 3 3 0 Major Vault Protein repeat domain Trypsin PF00089.26 EMC78475.1 - 7.1e-50 169.9 0.0 7.9e-50 169.7 0.0 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 EMC78475.1 - 5.5e-06 26.7 0.0 9.4e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) DUF551 PF04448.12 EMC78475.1 - 0.0096 16.8 0.0 0.024 15.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF551) Trypsin_2 PF13365.6 EMC78475.1 - 0.083 13.8 0.0 0.48 11.3 0.0 2.0 1 1 0 1 1 1 0 Trypsin-like peptidase domain PMSR PF01625.21 EMC78476.1 - 2e-53 180.7 0.9 2.3e-53 180.5 0.9 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Cornifin PF02389.15 EMC78477.1 - 1.8e-05 25.0 1.8 4.1e-05 23.8 1.8 1.6 1 1 0 1 1 1 1 Cornifin (SPRR) family HNF-1_N PF04814.13 EMC78478.1 - 2.8e-62 210.8 3.4 2.8e-62 210.8 3.4 1.9 2 0 0 2 2 2 1 Hepatocyte nuclear factor 1 (HNF-1), N terminus Homeodomain PF00046.29 EMC78478.1 - 3.7e-10 39.5 2.2 9.2e-10 38.2 0.1 2.7 3 1 0 3 3 3 1 Homeodomain Homeobox_KN PF05920.11 EMC78478.1 - 4.1e-05 23.4 0.7 0.0025 17.7 0.1 2.9 2 1 0 2 2 2 1 Homeobox KN domain HTH_37 PF13744.6 EMC78478.1 - 0.00036 20.4 0.4 0.0012 18.8 0.4 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 EMC78478.1 - 0.00085 19.3 0.3 0.054 13.5 0.0 2.9 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_3 PF01381.22 EMC78478.1 - 0.0033 17.5 0.1 0.0076 16.3 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix HTH_24 PF13412.6 EMC78478.1 - 0.015 14.9 0.2 0.066 12.8 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding AbiJ_NTD3 PF18860.1 EMC78478.1 - 0.022 14.3 0.2 0.4 10.2 0.1 2.5 3 0 0 3 3 3 0 AbiJ N-terminal domain 3 HTH_31 PF13560.6 EMC78478.1 - 0.025 14.9 2.6 0.086 13.2 0.1 2.8 3 1 0 3 3 3 0 Helix-turn-helix domain DUF494 PF04361.13 EMC78478.1 - 0.04 13.8 0.0 0.094 12.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF494) Pex14_N PF04695.13 EMC78478.1 - 0.059 14.0 3.4 0.09 13.4 1.2 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DSBA PF01323.20 EMC78478.1 - 0.07 12.9 0.2 1.2 8.8 0.0 2.8 3 0 0 3 3 3 0 DSBA-like thioredoxin domain CUT PF02376.15 EMC78478.1 - 0.09 13.0 0.8 0.32 11.2 0.1 2.2 2 0 0 2 2 2 0 CUT domain NOC3p PF07540.11 EMC78478.1 - 0.13 12.7 0.1 0.31 11.5 0.1 1.6 1 0 0 1 1 1 0 Nucleolar complex-associated protein YdaS_antitoxin PF15943.5 EMC78478.1 - 0.21 11.5 0.8 1 9.3 0.1 2.1 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_23 PF13384.6 EMC78478.1 - 0.57 10.0 4.6 0.28 11.0 0.2 2.7 3 0 0 3 3 2 0 Homeodomain-like domain Lactamase_B_6 PF16661.5 EMC78479.1 - 8.9e-16 57.9 1.1 5.6e-14 52.0 0.1 3.3 4 1 1 5 5 5 1 Metallo-beta-lactamase superfamily domain Beta-Casp PF10996.8 EMC78479.1 - 6.3e-07 29.7 0.0 1.2e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 Beta-Casp domain Beta_lactamase3 PF17030.5 EMC78479.1 - 0.01 15.1 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 Putative beta-lactamase-like family Glyco_transf_64 PF09258.10 EMC78481.1 - 2.6e-101 338.0 0.1 4.3e-101 337.3 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Exostosin PF03016.15 EMC78481.1 - 6.6e-56 189.7 0.0 1.2e-55 188.8 0.0 1.5 1 0 0 1 1 1 1 Exostosin family DUF812 PF05667.11 EMC78481.1 - 0.014 14.3 0.9 0.022 13.7 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) ADIP PF11559.8 EMC78481.1 - 0.017 15.2 7.2 0.028 14.5 7.2 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Jnk-SapK_ap_N PF09744.9 EMC78481.1 - 0.022 15.0 2.8 0.044 14.0 2.8 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF1664 PF07889.12 EMC78481.1 - 0.029 14.4 2.3 0.06 13.4 2.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Seryl_tRNA_N PF02403.22 EMC78481.1 - 0.048 13.9 4.9 0.096 12.9 4.9 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain MscS_porin PF12795.7 EMC78481.1 - 0.05 13.1 4.6 0.079 12.5 4.6 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain TPR_MLP1_2 PF07926.12 EMC78481.1 - 0.12 12.4 12.0 0.015 15.3 8.0 1.5 2 0 0 2 2 1 0 TPR/MLP1/MLP2-like protein THOC7 PF05615.13 EMC78481.1 - 0.15 12.3 5.9 0.075 13.3 3.3 1.7 2 0 0 2 2 2 0 Tho complex subunit 7 EzrA PF06160.12 EMC78481.1 - 0.16 10.1 4.0 0.25 9.5 4.0 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Noelin-1 PF12308.8 EMC78481.1 - 0.26 11.3 1.9 0.57 10.2 1.9 1.5 1 0 0 1 1 1 0 Neurogenesis glycoprotein BRE1 PF08647.11 EMC78481.1 - 0.32 11.1 6.5 0.59 10.2 6.5 1.3 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase CAMSAP_CC1 PF17095.5 EMC78481.1 - 0.34 10.8 1.6 0.66 9.9 1.6 1.4 1 0 0 1 1 1 0 Spectrin-binding region of Ca2+-Calmodulin TMPIT PF07851.13 EMC78481.1 - 0.42 9.8 3.1 0.85 8.8 3.1 1.4 1 0 0 1 1 1 0 TMPIT-like protein Tropomyosin_1 PF12718.7 EMC78481.1 - 0.5 10.5 6.2 0.98 9.6 6.2 1.4 1 0 0 1 1 1 0 Tropomyosin like DUF724 PF05266.14 EMC78481.1 - 1.9 8.3 4.9 3.5 7.4 4.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Spc7 PF08317.11 EMC78481.1 - 2 7.2 7.7 3.7 6.3 7.7 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein YlqD PF11068.8 EMC78481.1 - 4.8 7.6 7.5 9.8 6.6 7.5 1.4 1 0 0 1 1 1 0 YlqD protein EF-hand_6 PF13405.6 EMC78482.1 - 7.6e-12 44.2 6.6 2.6e-05 23.8 0.3 4.2 5 0 0 5 5 5 2 EF-hand domain EF-hand_1 PF00036.32 EMC78482.1 - 5.3e-11 41.3 11.7 1.7e-05 24.0 0.1 4.0 5 0 0 5 5 5 2 EF hand EF-hand_7 PF13499.6 EMC78482.1 - 1.2e-09 38.4 5.7 0.00021 21.6 0.9 3.6 2 2 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EMC78482.1 - 5.8e-09 35.0 3.7 2.4e-06 26.8 0.9 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EMC78482.1 - 3.3e-08 33.3 5.5 4.4e-05 23.2 0.1 3.4 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.7 EMC78482.1 - 2e-05 24.5 0.5 0.012 15.6 0.1 3.0 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand TcdB_toxin_midN PF12256.8 EMC78482.1 - 0.11 11.9 0.4 3.5 7.0 0.0 2.8 3 0 0 3 3 3 0 Insecticide toxin TcdB middle/N-terminal region Dockerin_1 PF00404.18 EMC78482.1 - 0.11 12.7 0.0 0.48 10.6 0.0 2.0 2 0 0 2 2 2 0 Dockerin type I domain DUF2415 PF10313.9 EMC78483.1 - 0.063 13.2 0.3 0.089 12.7 0.3 1.4 1 1 0 1 1 1 0 Uncharacterised protein domain (DUF2415) DUF1977 PF09320.11 EMC78484.1 - 1.8e-28 98.8 0.3 3.5e-28 97.9 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 EMC78484.1 - 5.2e-27 93.8 0.9 8.6e-27 93.1 0.9 1.4 1 0 0 1 1 1 1 DnaJ domain RPT PF13446.6 EMC78484.1 - 0.021 14.7 0.0 0.38 10.7 0.0 2.3 2 0 0 2 2 2 0 A repeated domain in UCH-protein KH_1 PF00013.29 EMC78485.1 - 9.9e-12 44.5 0.5 1.6e-11 43.9 0.5 1.3 1 0 0 1 1 1 1 KH domain AKAP7_NLS PF10469.9 EMC78485.1 - 0.00056 19.8 0.2 0.00076 19.4 0.2 1.2 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain KH_2 PF07650.17 EMC78485.1 - 0.011 15.6 0.0 0.019 14.8 0.0 1.5 1 0 0 1 1 1 0 KH domain MTS_N PF08468.11 EMC78485.1 - 0.098 12.7 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain N-terminal AKAP7_NLS PF10469.9 EMC78486.1 - 3.5e-15 56.4 0.1 3.9e-15 56.3 0.1 1.0 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain SPARC_Ca_bdg PF10591.9 EMC78487.1 - 3.4e-29 101.5 0.0 7e-29 100.4 0.0 1.5 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Thyroglobulin_1 PF00086.18 EMC78487.1 - 8.3e-18 63.8 3.4 8.3e-18 63.8 3.4 2.2 2 0 0 2 2 2 1 Thyroglobulin type-1 repeat Kazal_2 PF07648.15 EMC78487.1 - 6.2e-11 42.2 7.5 6.2e-11 42.2 7.5 2.7 3 0 0 3 3 3 1 Kazal-type serine protease inhibitor domain EF-hand_7 PF13499.6 EMC78487.1 - 0.00013 22.4 0.0 0.0004 20.8 0.0 1.9 1 1 0 1 1 1 1 EF-hand domain pair Kazal_1 PF00050.21 EMC78487.1 - 0.0012 18.8 5.2 0.0012 18.8 5.2 2.6 3 0 0 3 3 3 1 Kazal-type serine protease inhibitor domain EF-hand_6 PF13405.6 EMC78487.1 - 0.0023 17.7 0.0 0.31 11.1 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 EMC78487.1 - 0.0049 16.3 0.0 0.21 11.2 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_10 PF14788.6 EMC78487.1 - 0.032 14.1 0.1 0.23 11.3 0.0 2.0 1 1 1 2 2 2 0 EF hand EF-hand_5 PF13202.6 EMC78487.1 - 0.055 13.0 0.0 0.73 9.4 0.0 2.8 3 0 0 3 3 3 0 EF hand Cadherin PF00028.17 EMC78488.1 - 1.6e-49 166.3 0.0 2.5e-19 69.5 0.0 4.1 4 0 0 4 4 4 4 Cadherin domain Cadherin_3 PF16184.5 EMC78488.1 - 8.6e-06 25.7 0.0 0.00047 20.1 0.0 2.6 3 0 0 3 3 3 1 Cadherin-like Sharpin_PH PF16764.5 EMC78488.1 - 0.00014 21.6 0.0 0.059 13.1 0.0 2.4 2 0 0 2 2 2 2 Sharpin PH domain Cadherin_2 PF08266.12 EMC78488.1 - 0.00025 20.8 0.0 0.033 14.0 0.0 3.2 3 0 0 3 3 3 1 Cadherin-like RET_CLD1 PF17756.1 EMC78488.1 - 0.029 14.7 0.0 0.06 13.6 0.0 1.6 1 0 0 1 1 1 0 RET Cadherin like domain 1 Acetyltransf_17 PF17668.1 EMC78488.1 - 0.052 14.4 0.0 1.2 10.0 0.0 2.4 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Pkinase PF00069.25 EMC78489.1 - 2.1e-64 217.4 0.0 2.9e-64 217.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC78489.1 - 1.2e-37 129.7 0.0 1.6e-37 129.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C2 PF00168.30 EMC78489.1 - 1.4e-29 102.4 0.1 2.3e-29 101.7 0.1 1.3 1 0 0 1 1 1 1 C2 domain C1_1 PF00130.22 EMC78489.1 - 4.9e-18 64.8 15.9 2e-16 59.6 4.8 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 EMC78489.1 - 0.00031 21.4 0.6 0.0009 19.9 0.6 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 EMC78489.1 - 0.024 13.6 0.1 0.036 13.0 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 EMC78489.1 - 0.037 13.3 0.0 0.066 12.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 EMC78489.1 - 0.14 12.0 0.0 0.36 10.7 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family PMP22_Claudin PF00822.20 EMC78490.1 - 8.9e-22 77.7 3.9 2.1e-21 76.5 3.9 1.6 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC78490.1 - 5.6e-21 75.2 3.8 8.2e-21 74.6 3.8 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF716 PF04819.12 EMC78490.1 - 0.022 14.4 0.2 0.041 13.5 0.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF716) DHHC PF01529.20 EMC78490.1 - 0.82 9.8 7.1 0.13 12.3 2.3 2.0 1 1 1 2 2 2 0 DHHC palmitoyltransferase Claudin_3 PF06653.11 EMC78490.1 - 1.4 8.8 9.7 3.7 7.5 9.7 1.6 1 1 0 1 1 1 0 Tight junction protein, Claudin-like Tetraspanin PF00335.20 EMC78490.1 - 3.6 7.2 7.9 2.9 7.6 1.9 2.4 2 1 0 2 2 2 0 Tetraspanin family MFS_1 PF07690.16 EMC78490.1 - 3.6 6.4 15.6 0.61 8.9 8.5 1.9 1 1 0 2 2 2 0 Major Facilitator Superfamily DUF4199 PF13858.6 EMC78490.1 - 4.7 7.6 10.9 5.8 7.3 10.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4199) CD20 PF04103.15 EMC78490.1 - 5.9 7.0 12.7 17 5.4 0.1 3.6 2 1 1 3 3 3 0 CD20-like family PMP22_Claudin PF00822.20 EMC78491.1 - 2.3e-24 86.1 0.0 4.3e-24 85.2 0.0 1.4 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC78491.1 - 4.1e-10 39.7 0.0 6.2e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction AA_permease_2 PF13520.6 EMC78491.1 - 0.0032 16.4 0.1 0.0043 15.9 0.1 1.1 1 0 0 1 1 1 1 Amino acid permease DUF2269 PF10027.9 EMC78491.1 - 0.015 15.3 0.0 0.025 14.7 0.0 1.2 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2269) DUF4199 PF13858.6 EMC78491.1 - 0.023 15.1 0.0 0.031 14.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Claudin_2 PF13903.6 EMC78492.1 - 1.2e-38 132.9 6.0 1.5e-38 132.5 6.0 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 EMC78492.1 - 8.5e-16 58.3 9.9 1.6e-09 37.9 5.6 2.1 2 0 0 2 2 2 2 PMP-22/EMP/MP20/Claudin family Claudin_3 PF06653.11 EMC78492.1 - 0.045 13.7 7.2 0.31 11.0 3.7 2.2 2 0 0 2 2 2 0 Tight junction protein, Claudin-like DuoxA PF10204.9 EMC78492.1 - 0.13 11.2 5.4 0.041 12.9 2.1 1.7 2 0 0 2 2 2 0 Dual oxidase maturation factor UNC-50 PF05216.13 EMC78492.1 - 0.13 11.8 7.1 0.019 14.5 3.3 1.4 2 0 0 2 2 2 0 UNC-50 family DUF981 PF06168.11 EMC78492.1 - 0.26 11.2 5.5 1.2 9.0 3.9 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF981) DUF805 PF05656.14 EMC78492.1 - 0.49 10.8 4.2 0.18 12.2 1.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF805) LapA_dom PF06305.11 EMC78492.1 - 0.57 10.0 0.0 0.57 10.0 0.0 2.3 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Phage_holin_3_6 PF07332.11 EMC78492.1 - 0.91 9.6 7.3 13 5.9 4.6 2.9 2 1 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF2207 PF09972.9 EMC78492.1 - 7.3 5.2 7.7 3.3 6.4 5.2 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) AAA_12 PF13087.6 EMC78493.1 - 2.3e-35 122.0 1.1 2.7e-34 118.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EMC78493.1 - 1.1e-23 84.4 6.9 2.2e-12 47.3 0.1 3.3 2 1 1 3 3 2 2 AAA domain AAA_19 PF13245.6 EMC78493.1 - 5.1e-10 39.9 0.0 6.8e-08 33.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EMC78493.1 - 8e-09 35.5 0.0 3.8e-08 33.3 0.0 2.1 2 1 0 2 2 2 1 AAA domain zf-CCCH PF00642.24 EMC78493.1 - 7.4e-08 32.1 0.6 2e-07 30.8 0.6 1.8 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) ResIII PF04851.15 EMC78493.1 - 1.8e-05 24.8 0.0 4.1e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.16 EMC78493.1 - 2.5e-05 23.9 0.0 0.02 14.4 0.0 2.3 2 0 0 2 2 2 2 PhoH-like protein UvrD-helicase PF00580.21 EMC78493.1 - 0.00011 21.9 0.0 0.00011 21.9 0.0 2.8 4 0 0 4 4 4 1 UvrD/REP helicase N-terminal domain PAM2 PF07145.15 EMC78493.1 - 0.00022 20.7 0.1 0.00092 18.7 0.1 2.2 1 0 0 1 1 1 1 Ataxin-2 C-terminal region zf_CCCH_4 PF18345.1 EMC78493.1 - 0.0011 18.9 1.2 0.0029 17.6 1.2 1.8 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 EMC78493.1 - 0.0055 16.5 0.3 0.014 15.2 0.3 1.7 1 0 0 1 1 1 1 CCCH-type zinc finger AAA_7 PF12775.7 EMC78493.1 - 0.017 14.6 0.0 0.072 12.6 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_22 PF13401.6 EMC78493.1 - 0.037 14.3 0.0 0.18 12.1 0.0 2.3 1 0 0 1 1 1 0 AAA domain Helicase_RecD PF05127.14 EMC78493.1 - 0.039 13.8 0.1 0.24 11.2 0.0 2.4 2 0 0 2 2 2 0 Helicase AAA_14 PF13173.6 EMC78493.1 - 0.039 14.0 0.0 1.8 8.6 0.0 2.8 2 0 0 2 2 2 0 AAA domain Bac_DnaA PF00308.18 EMC78493.1 - 0.068 13.0 0.3 0.31 10.8 0.0 2.2 3 0 0 3 3 3 0 Bacterial dnaA protein AAA_16 PF13191.6 EMC78493.1 - 0.084 13.2 0.0 0.5 10.7 0.0 2.3 2 0 0 2 2 1 0 AAA ATPase domain AAA_5 PF07728.14 EMC78493.1 - 0.14 12.2 0.1 0.63 10.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) PCI PF01399.27 EMC78494.1 - 3.4e-23 82.2 2.1 9.8e-23 80.7 0.0 2.7 2 1 0 2 2 2 1 PCI domain RPN5_C PF18098.1 EMC78494.1 - 4.8e-15 55.4 8.6 1.1e-14 54.2 8.6 1.7 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain Hydrophob_seed PF14547.6 EMC78494.1 - 0.1 12.8 0.1 0.27 11.5 0.1 1.7 1 0 0 1 1 1 0 Hydrophobic seed protein Retrotrans_gag PF03732.17 EMC78494.1 - 0.25 11.7 1.3 25 5.2 0.0 3.7 3 1 1 4 4 4 0 Retrotransposon gag protein IP_trans PF02121.18 EMC78495.1 - 2.8e-94 315.3 1.8 3.3e-94 315.1 1.8 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein NUC205 PF08168.11 EMC78496.1 - 1.9e-05 24.1 0.1 0.00011 21.7 0.0 2.3 2 0 0 2 2 2 1 NUC205 domain HisG_C PF08029.11 EMC78496.1 - 0.017 15.3 0.1 0.69 10.1 0.0 2.8 3 0 0 3 3 3 0 HisG, C-terminal domain UTP15_C PF09384.10 EMC78496.1 - 0.022 14.4 0.0 0.051 13.3 0.0 1.6 1 0 0 1 1 1 0 UTP15 C terminal DDT PF02791.17 EMC78497.1 - 2.4e-17 63.0 0.3 5.2e-17 61.9 0.3 1.6 1 0 0 1 1 1 1 DDT domain WSD PF15613.6 EMC78497.1 - 1e-09 38.7 2.6 1e-09 38.7 2.6 5.0 4 1 0 4 4 4 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif PHD PF00628.29 EMC78497.1 - 3.6e-08 33.2 13.6 3.6e-08 33.2 13.6 2.2 2 0 0 2 2 2 1 PHD-finger WHIM1 PF15612.6 EMC78497.1 - 0.0001 21.8 0.0 0.00037 20.0 0.0 1.9 2 0 0 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 1 Arc_PepC_II PF06847.11 EMC78497.1 - 0.12 13.0 1.3 1.1 9.8 0.4 3.2 2 0 0 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II DUF3213 PF11491.8 EMC78497.1 - 2.9 8.2 8.1 9.5 6.5 0.0 4.1 5 0 0 5 5 5 0 Protein of unknown function (DUF3213) Bromodomain PF00439.25 EMC78498.1 - 2.7e-26 91.5 0.2 5.7e-26 90.4 0.2 1.6 1 0 0 1 1 1 1 Bromodomain PHD PF00628.29 EMC78498.1 - 5.5e-10 39.0 7.1 5.5e-10 39.0 7.1 2.0 2 0 0 2 2 2 1 PHD-finger zf-HC5HC2H PF13771.6 EMC78498.1 - 1.2 9.5 5.2 5.9 7.2 5.2 2.2 1 0 0 1 1 1 0 PHD-like zinc-binding domain PHD_4 PF16866.5 EMC78498.1 - 1.2 9.3 3.9 3.4 7.8 3.9 1.8 1 0 0 1 1 1 0 PHD-finger zinc_ribbon_15 PF17032.5 EMC78498.1 - 5.8 7.7 10.7 0.58 10.9 5.4 2.1 2 0 0 2 2 2 0 zinc-ribbon family NTR PF01759.21 EMC78499.1 - 0.018 14.8 0.1 0.038 13.8 0.1 1.6 1 1 0 1 1 1 0 UNC-6/NTR/C345C module CEP44 PF15007.6 EMC78500.1 - 3.4e-42 143.6 1.3 6.7e-42 142.6 0.6 1.9 2 0 0 2 2 2 1 Centrosomal spindle body, CEP44 adh_short PF00106.25 EMC78501.1 - 1.4e-58 197.6 0.2 2e-58 197.1 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC78501.1 - 2.2e-44 151.8 0.0 2.8e-44 151.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC78501.1 - 1.6e-14 54.2 0.2 2.2e-14 53.8 0.2 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EMC78501.1 - 1.6e-09 37.6 0.1 2.1e-09 37.2 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMC78501.1 - 6e-07 29.2 0.1 8.2e-07 28.7 0.1 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EMC78501.1 - 6.3e-05 22.1 0.2 9.1e-05 21.6 0.2 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 EMC78501.1 - 0.00014 21.6 0.4 0.0002 21.0 0.4 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMC78501.1 - 0.00048 20.1 0.2 0.00084 19.3 0.2 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EMC78501.1 - 0.0015 17.7 0.1 0.0024 17.0 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 EMC78501.1 - 0.0021 18.3 0.1 0.008 16.4 0.2 1.8 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain 3HCDH_N PF02737.18 EMC78501.1 - 0.082 12.8 0.3 0.14 12.1 0.3 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 EMC78501.1 - 0.12 11.8 0.1 0.2 11.0 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 EMC78501.1 - 0.19 10.8 0.1 0.26 10.3 0.1 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Neur_chan_LBD PF02931.23 EMC78502.1 - 7.5e-41 139.9 0.4 1.1e-40 139.4 0.4 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC78502.1 - 9.5e-38 130.6 7.1 9.4e-33 114.2 3.0 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Toxin_TOLIP PF00087.21 EMC78503.1 - 3.3e-11 43.3 16.8 5.1e-11 42.7 16.8 1.3 1 0 0 1 1 1 1 Snake toxin and toxin-like protein UPAR_LY6 PF00021.21 EMC78503.1 - 4.7e-10 40.0 16.3 6.2e-10 39.7 16.3 1.2 1 0 0 1 1 1 1 u-PAR/Ly-6 domain DUF1075 PF06388.11 EMC78503.1 - 0.53 10.3 3.0 0.45 10.6 1.6 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1075) Toxin_TOLIP PF00087.21 EMC78504.1 - 6.7e-12 45.5 14.6 8.7e-12 45.1 14.6 1.1 1 0 0 1 1 1 1 Snake toxin and toxin-like protein UPAR_LY6 PF00021.21 EMC78504.1 - 1.2e-10 41.9 13.4 1.6e-10 41.6 13.4 1.1 1 0 0 1 1 1 1 u-PAR/Ly-6 domain UPAR_LY6_2 PF16975.5 EMC78504.1 - 0.0003 20.9 15.1 0.00071 19.8 15.1 1.6 1 1 0 1 1 1 1 Ly6/PLAUR domain-containing protein 6, Lypd6 UPAR_LY6 PF00021.21 EMC78505.1 - 4.3e-16 59.4 9.8 5.2e-16 59.1 9.8 1.1 1 0 0 1 1 1 1 u-PAR/Ly-6 domain Toxin_TOLIP PF00087.21 EMC78505.1 - 3.8e-09 36.7 9.6 4.6e-09 36.4 9.6 1.1 1 0 0 1 1 1 1 Snake toxin and toxin-like protein UPAR_LY6_2 PF16975.5 EMC78505.1 - 0.15 12.3 8.2 0.23 11.7 8.2 1.4 1 1 0 1 1 1 0 Ly6/PLAUR domain-containing protein 6, Lypd6 UPAR_LY6 PF00021.21 EMC78506.1 - 2.8e-06 27.9 11.4 4.1e-06 27.4 11.4 1.3 1 0 0 1 1 1 1 u-PAR/Ly-6 domain Toxin_TOLIP PF00087.21 EMC78506.1 - 0.00011 22.3 12.1 0.00019 21.6 12.1 1.4 1 0 0 1 1 1 1 Snake toxin and toxin-like protein BAMBI PF06211.12 EMC78506.1 - 0.2 11.9 8.1 0.54 10.5 8.1 1.7 1 1 0 1 1 1 0 BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain UPAR_LY6 PF00021.21 EMC78507.1 - 7e-05 23.5 11.7 9.1e-05 23.1 11.7 1.2 1 0 0 1 1 1 1 u-PAR/Ly-6 domain Toxin_TOLIP PF00087.21 EMC78507.1 - 0.0003 21.0 12.7 0.00038 20.6 12.7 1.1 1 0 0 1 1 1 1 Snake toxin and toxin-like protein ARTD15_N PF18084.1 EMC78507.1 - 0.0038 17.4 0.2 1.1 9.5 0.0 2.3 2 0 0 2 2 2 2 ARTD15 N-terminal domain UPAR_LY6_2 PF16975.5 EMC78507.1 - 0.032 14.4 9.6 0.049 13.8 9.6 1.3 1 0 0 1 1 1 0 Ly6/PLAUR domain-containing protein 6, Lypd6 Toxin_TOLIP PF00087.21 EMC78508.1 - 1.6e-06 28.3 13.6 2e-06 28.0 13.6 1.1 1 0 0 1 1 1 1 Snake toxin and toxin-like protein UPAR_LY6 PF00021.21 EMC78508.1 - 2.1e-06 28.3 15.1 2.7e-06 28.0 15.1 1.1 1 0 0 1 1 1 1 u-PAR/Ly-6 domain MORN PF02493.20 EMC78509.1 - 1.1e-35 119.3 45.6 1.2e-09 37.5 3.6 7.8 8 0 0 8 8 8 7 MORN repeat Vmethyltransf PF01660.17 EMC78509.1 - 0.3 9.9 1.1 0.42 9.4 1.1 1.2 1 0 0 1 1 1 0 Viral methyltransferase Trypsin PF00089.26 EMC78510.1 - 9.4e-72 241.4 0.7 1.4e-71 240.9 0.7 1.2 1 0 0 1 1 1 1 Trypsin SRCR_2 PF15494.6 EMC78510.1 - 1.8e-26 92.5 1.7 3.9e-26 91.5 1.7 1.6 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 EMC78510.1 - 5.3e-10 39.8 1.0 1.4e-09 38.5 1.0 1.6 1 0 0 1 1 1 1 Hepsin, SRCR domain SRCR PF00530.18 EMC78510.1 - 3.4e-07 30.7 0.4 1.2e-06 28.9 0.2 2.0 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Ldl_recept_a PF00057.18 EMC78510.1 - 5.9e-06 26.4 8.0 2.3e-05 24.5 8.0 2.1 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A DUF1986 PF09342.11 EMC78510.1 - 1.1e-05 25.7 0.1 2.4e-05 24.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 EMC78510.1 - 7.6e-05 23.6 0.0 0.00015 22.7 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trefoil PF00088.18 EMC78511.1 - 6.4e-26 90.0 24.3 4.2e-13 48.9 8.2 2.1 2 0 0 2 2 2 2 Trefoil (P-type) domain TEX29 PF15839.5 EMC78511.1 - 1 10.0 10.3 2.3 8.9 1.1 2.5 1 1 1 2 2 2 0 Testis-expressed sequence 29 protein ABC2_membrane PF01061.24 EMC78512.1 - 6.2e-47 159.7 25.7 9.6e-47 159.1 25.7 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EMC78512.1 - 5.8e-30 104.6 0.0 9.4e-30 103.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EMC78512.1 - 2.6e-07 30.8 0.0 0.003 17.4 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EMC78512.1 - 1.3e-06 28.0 0.0 4.6e-06 26.2 0.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EMC78512.1 - 0.0001 22.3 0.0 0.0002 21.3 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_13 PF13166.6 EMC78512.1 - 0.0051 15.5 0.0 0.084 11.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EMC78512.1 - 0.0065 16.9 0.0 0.014 15.8 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 EMC78512.1 - 0.0066 16.2 0.6 0.015 15.0 0.6 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EMC78512.1 - 0.012 15.7 0.1 0.022 14.8 0.1 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_23 PF13476.6 EMC78512.1 - 0.027 15.0 0.3 0.046 14.2 0.3 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EMC78512.1 - 0.045 14.3 0.0 0.088 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EMC78512.1 - 0.047 14.0 0.1 0.15 12.4 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EMC78512.1 - 0.062 13.5 0.1 0.12 12.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EMC78512.1 - 0.068 12.9 0.1 0.14 11.9 0.1 1.4 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EMC78512.1 - 0.081 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain Cytidylate_kin PF02224.18 EMC78512.1 - 0.18 11.5 0.0 0.33 10.6 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase DUF1440 PF07274.12 EMC78512.1 - 0.24 11.7 4.2 3.5 8.0 0.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1440) BTB PF00651.31 EMC78513.1 - 6e-26 90.9 0.2 7e-26 90.6 0.2 1.0 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.8 EMC78513.1 - 4.7e-07 29.9 0.1 6.9e-07 29.4 0.1 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF3342) BTB_2 PF02214.22 EMC78513.1 - 6.2e-05 23.3 0.0 8.3e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain DUF1367 PF07105.11 EMC78513.1 - 0.059 13.0 0.0 0.067 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1367) Stathmin PF00836.19 EMC78514.1 - 1.6e-43 147.9 12.4 1.7e-43 147.8 12.4 1.0 1 0 0 1 1 1 1 Stathmin family HTH_8 PF02954.19 EMC78514.1 - 0.095 12.5 0.5 0.095 12.5 0.5 2.2 1 1 0 1 1 1 0 Bacterial regulatory protein, Fis family HlyIII PF03006.20 EMC78515.1 - 9.4e-49 166.1 15.8 1.3e-48 165.6 15.8 1.2 1 0 0 1 1 1 1 Haemolysin-III related Frag1 PF10277.9 EMC78515.1 - 0.00018 21.1 4.9 0.00018 21.1 4.9 2.2 2 1 0 2 2 2 1 Frag1/DRAM/Sfk1 family Fer4_18 PF13746.6 EMC78515.1 - 0.13 12.4 0.0 0.23 11.7 0.0 1.3 1 0 0 1 1 1 0 4Fe-4S dicluster domain Mito_fiss_reg PF05308.11 EMC78516.1 - 2e-72 244.3 1.2 2.4e-72 244.0 1.2 1.1 1 0 0 1 1 1 1 Mitochondrial fission regulator PID PF00640.23 EMC78518.1 - 1.4e-17 64.0 0.5 2.2e-17 63.4 0.5 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PID_2 PF14719.6 EMC78518.1 - 1.6e-17 63.9 0.0 2.1e-17 63.6 0.0 1.1 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 EMC78518.1 - 2.4e-07 31.0 0.1 4.3e-07 30.1 0.1 1.4 1 0 0 1 1 1 1 Phosphotyrosine-binding domain Ammonium_transp PF00909.21 EMC78519.1 - 1.9e-50 171.7 26.3 4.2e-49 167.3 27.2 1.8 1 1 1 2 2 2 2 Ammonium Transporter Family GWT1 PF06423.12 EMC78519.1 - 0.00011 22.4 0.9 0.00047 20.3 0.1 2.5 2 0 0 2 2 2 1 GWT1 NiFe_hyd_3_EhaA PF17367.2 EMC78519.1 - 0.69 10.1 9.9 2.2 8.5 0.0 3.4 3 0 0 3 3 3 0 NiFe-hydrogenase-type-3 Eha complex subunit A UPF0220 PF05255.11 EMC78520.1 - 4.5e-47 159.7 4.3 5e-47 159.5 4.3 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) TMEM107 PF14995.6 EMC78520.1 - 0.55 10.7 0.1 0.55 10.7 0.1 2.4 2 1 1 3 3 3 0 Transmembrane protein RSRP PF17069.5 EMC78521.1 - 2.7e-47 161.8 106.0 3.9e-47 161.3 106.0 1.3 1 1 0 1 1 1 1 Arginine/Serine-Rich protein 1 Pol_alpha_B_N PF08418.10 EMC78521.1 - 0.054 13.5 7.4 0.081 12.9 7.4 1.3 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal CCDC106 PF15794.5 EMC78521.1 - 8.6 6.0 24.4 10 5.7 23.7 1.5 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 106 Presenilin PF01080.17 EMC78521.1 - 9.7 4.8 5.8 9.5 4.9 5.8 1.2 1 0 0 1 1 1 0 Presenilin SYF2 PF08231.12 EMC78522.1 - 5.3e-57 192.7 12.6 5.3e-57 192.7 12.6 1.5 2 0 0 2 2 2 1 SYF2 splicing factor rve_3 PF13683.6 EMC78522.1 - 0.016 15.0 0.1 0.42 10.4 0.0 2.6 2 0 0 2 2 2 0 Integrase core domain FUSC-like PF12805.7 EMC78522.1 - 0.075 12.1 0.3 0.11 11.6 0.3 1.2 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS ARD PF03079.14 EMC78522.1 - 7.5 6.7 11.3 0.61 10.3 0.7 2.4 1 1 2 3 3 3 0 ARD/ARD' family Runt PF00853.19 EMC78523.1 - 2.1e-73 244.0 0.2 3e-73 243.5 0.2 1.2 1 0 0 1 1 1 1 Runt domain RunxI PF08504.11 EMC78523.1 - 5.7e-45 152.1 6.0 1.4e-44 150.8 6.0 1.7 1 0 0 1 1 1 1 Runx inhibition domain GST_C_2 PF13410.6 EMC78524.1 - 4.3e-07 29.9 0.0 8.9e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EMC78524.1 - 3.8e-05 24.0 0.0 6.6e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EMC78524.1 - 4.1e-05 23.8 0.0 8.4e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EMC78524.1 - 0.0048 17.1 0.2 0.028 14.6 0.0 2.2 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EMC78524.1 - 0.14 12.4 0.1 0.44 10.8 0.0 1.9 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain SKG6 PF08693.10 EMC78525.1 - 0.00065 19.1 1.0 0.001 18.5 1.0 1.3 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF2207 PF09972.9 EMC78525.1 - 0.0079 15.0 0.0 0.0085 14.9 0.0 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) MscL PF01741.18 EMC78525.1 - 0.0096 16.2 0.0 0.011 16.0 0.0 1.1 1 0 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL DUF2976 PF11190.8 EMC78525.1 - 0.015 15.1 0.1 0.018 14.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2976) RIFIN PF02009.16 EMC78525.1 - 0.015 15.2 0.3 0.017 15.0 0.3 1.1 1 0 0 1 1 1 0 Rifin m04gp34like PF12216.8 EMC78525.1 - 0.024 14.2 0.3 0.03 13.9 0.3 1.1 1 0 0 1 1 1 0 Immune evasion protein Amnionless PF14828.6 EMC78525.1 - 0.025 13.4 0.1 0.026 13.4 0.1 1.0 1 0 0 1 1 1 0 Amnionless EphA2_TM PF14575.6 EMC78525.1 - 0.036 14.9 0.0 0.051 14.5 0.0 1.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Adeno_E3_CR2 PF02439.15 EMC78525.1 - 0.043 13.6 2.5 0.064 13.0 2.5 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 TMEM154 PF15102.6 EMC78525.1 - 0.072 13.0 0.1 0.084 12.8 0.1 1.3 1 0 0 1 1 1 0 TMEM154 protein family Syndecan PF01034.20 EMC78525.1 - 0.085 12.8 1.3 0.12 12.3 1.3 1.2 1 0 0 1 1 1 0 Syndecan domain S1FA PF04689.13 EMC78525.1 - 0.12 12.6 0.1 0.17 12.0 0.1 1.2 1 0 0 1 1 1 0 DNA binding protein S1FA Calcipressin PF04847.12 EMC78526.1 - 3.9e-58 196.3 0.3 5.3e-58 195.8 0.3 1.2 1 0 0 1 1 1 1 Calcipressin RRM_occluded PF16842.5 EMC78526.1 - 0.16 11.8 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif Mg_trans_NIPA PF05653.14 EMC78527.1 - 9.3e-71 238.3 20.1 1.1e-70 238.1 20.1 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA 7TMR-DISM_7TM PF07695.11 EMC78527.1 - 0.15 11.9 32.6 0.26 11.1 18.5 2.4 1 1 1 2 2 2 0 7TM diverse intracellular signalling CP2 PF04516.15 EMC78528.1 - 6e-86 287.5 0.1 8.7e-86 287.0 0.1 1.2 1 0 0 1 1 1 1 CP2 transcription factor Tissue_fac PF01108.17 EMC78529.1 - 4.4e-22 77.9 0.0 7.2e-22 77.3 0.0 1.4 1 0 0 1 1 1 1 Tissue factor Interfer-bind PF09294.10 EMC78529.1 - 4e-08 33.5 0.2 8.9e-08 32.4 0.1 1.7 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.21 EMC78529.1 - 0.00097 19.4 0.4 0.022 15.1 0.1 2.6 2 1 0 2 2 2 1 Fibronectin type III domain IL6Ra-bind PF09240.10 EMC78529.1 - 0.0025 18.2 0.0 0.0053 17.1 0.0 1.6 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding Tissue_fac PF01108.17 EMC78530.1 - 1.3e-23 82.9 0.1 3.3e-23 81.6 0.1 1.6 1 0 0 1 1 1 1 Tissue factor Interfer-bind PF09294.10 EMC78530.1 - 2.1e-06 28.0 0.1 5.6e-06 26.6 0.1 1.7 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.21 EMC78530.1 - 0.049 14.0 2.8 0.28 11.5 0.3 2.6 2 0 0 2 2 2 0 Fibronectin type III domain fn3 PF00041.21 EMC78531.1 - 1e-87 288.6 0.1 7.9e-19 67.8 0.0 6.1 5 0 0 5 5 5 5 Fibronectin type III domain I-set PF07679.16 EMC78531.1 - 2.9e-63 209.9 6.6 8.4e-18 64.2 0.4 7.7 7 0 0 7 7 7 7 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC78531.1 - 9.5e-46 154.3 1.5 7.1e-10 39.4 0.0 7.7 7 0 0 7 7 7 7 Immunoglobulin domain ig PF00047.25 EMC78531.1 - 8.7e-27 93.1 12.1 1.9e-05 24.8 0.0 7.4 8 0 0 8 8 8 5 Immunoglobulin domain Ig_2 PF13895.6 EMC78531.1 - 2.2e-26 92.0 5.0 1.9e-05 24.9 0.0 6.7 6 0 0 6 6 6 4 Immunoglobulin domain V-set PF07686.17 EMC78531.1 - 2.2e-14 53.5 21.8 0.11 12.7 0.2 10.7 7 4 1 8 8 8 4 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.5 EMC78531.1 - 1.9e-10 41.1 0.2 0.07 13.7 0.0 6.8 5 1 0 5 5 5 2 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.12 EMC78531.1 - 8.2e-07 29.0 0.1 0.18 11.9 0.0 4.3 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain fn3_2 PF16893.5 EMC78531.1 - 7e-06 26.1 0.0 0.07 13.3 0.0 3.4 3 0 0 3 3 3 2 Fibronectin type III domain Interfer-bind PF09294.10 EMC78531.1 - 9.6e-05 22.7 0.2 5 7.5 0.0 4.7 5 0 0 5 5 5 2 Interferon-alpha/beta receptor, fibronectin type III DUF4926 PF16277.5 EMC78531.1 - 0.003 16.9 0.4 0.51 9.7 0.0 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4926) Lipocalin_7 PF14651.6 EMC78532.1 - 2.9e-33 114.5 1.1 3.2e-33 114.4 1.1 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin PF00061.23 EMC78532.1 - 6.5e-19 68.6 1.4 7.2e-19 68.4 1.4 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family PNRC PF15365.6 EMC78533.1 - 3.6e-07 29.8 6.7 3.6e-07 29.8 6.7 1.7 2 0 0 2 2 2 1 Proline-rich nuclear receptor coactivator motif Ribosomal_S20p PF01649.18 EMC78533.1 - 0.0081 16.8 1.3 0.012 16.2 1.3 1.4 1 0 0 1 1 1 1 Ribosomal protein S20 7tm_1 PF00001.21 EMC78534.1 - 6.8e-37 127.2 22.1 1e-36 126.6 22.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC78534.1 - 9.8e-12 45.2 10.4 9.6e-08 32.1 1.1 2.2 2 0 0 2 2 2 2 Olfactory receptor Abhydrolase_9_N PF15420.6 EMC78534.1 - 3.4 7.6 9.9 12 5.8 9.9 1.9 1 1 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus Alpha_L_fucos PF01120.17 EMC78535.1 - 8.8e-117 390.5 5.7 1e-116 390.3 5.7 1.0 1 0 0 1 1 1 1 Alpha-L-fucosidase Fucosidase_C PF16757.5 EMC78535.1 - 1.8e-20 73.3 0.0 4.7e-20 72.0 0.0 1.7 1 0 0 1 1 1 1 Alpha-L-fucosidase C-terminal domain HMGL-like PF00682.19 EMC78536.1 - 4e-70 236.4 0.0 4.6e-70 236.2 0.0 1.0 1 0 0 1 1 1 1 HMGL-like GDP_Man_Dehyd PF16363.5 EMC78537.1 - 7.1e-58 196.6 0.0 8.3e-58 196.3 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EMC78537.1 - 1.5e-51 175.2 0.0 1.9e-51 174.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EMC78537.1 - 1.3e-18 67.0 0.0 7.2e-17 61.3 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EMC78537.1 - 2e-13 50.1 0.1 4.5e-11 42.4 0.0 2.8 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EMC78537.1 - 9.1e-13 47.9 0.0 1.7e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EMC78537.1 - 7.7e-07 28.5 0.0 4.5e-05 22.8 0.0 2.2 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EMC78537.1 - 1.1e-05 25.4 0.0 3.3e-05 23.9 0.0 1.8 1 1 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EMC78537.1 - 1.4e-05 25.1 0.0 2.6e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 EMC78537.1 - 4.1e-05 23.1 0.0 0.00014 21.4 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.13 EMC78537.1 - 0.00075 19.1 0.4 0.31 10.6 0.1 2.7 2 1 0 2 2 2 2 NmrA-like family Abhydrolase_2 PF02230.16 EMC78538.1 - 6.2e-81 271.3 0.0 6.9e-81 271.2 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EMC78538.1 - 0.003 16.8 0.0 0.045 13.0 0.0 2.4 2 1 1 3 3 3 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EMC78538.1 - 0.025 14.1 0.0 0.082 12.4 0.0 1.8 2 0 0 2 2 2 0 Prolyl oligopeptidase family DLH PF01738.18 EMC78538.1 - 0.033 13.7 0.0 0.055 13.0 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family Collagen PF01391.18 EMC78539.1 - 5.1e-17 61.4 56.1 1e-09 38.0 28.2 2.9 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) PITH PF06201.13 EMC78540.1 - 9.9e-31 107.0 0.0 1.2e-30 106.7 0.0 1.1 1 0 0 1 1 1 1 PITH domain BLOC1S3 PF15753.5 EMC78540.1 - 0.18 11.9 0.0 0.29 11.2 0.0 1.2 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 7tm_1 PF00001.21 EMC78541.1 - 9.7e-50 169.3 23.0 1.2e-49 169.0 23.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC78541.1 - 0.01 15.2 23.5 0.013 14.8 23.5 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx DUF621 PF04789.15 EMC78541.1 - 0.13 11.5 23.6 0.23 10.6 23.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF621) HMG_box PF00505.19 EMC78542.1 - 3.1e-18 66.0 1.7 3.1e-18 66.0 1.7 2.5 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC78542.1 - 4.5e-06 27.2 0.6 4.5e-06 27.2 0.6 2.7 2 1 0 2 2 2 1 HMG-box domain Pepsin-I3 PF06394.13 EMC78542.1 - 0.31 11.3 0.2 0.31 11.3 0.2 2.1 2 0 0 2 2 2 0 Pepsin inhibitor-3-like repeated domain DUF4296 PF14129.6 EMC78542.1 - 0.5 11.0 5.2 8.3 7.1 0.7 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4296) Filament PF00038.21 EMC78543.1 - 7.7e-107 357.5 21.6 9.4e-107 357.2 21.6 1.1 1 0 0 1 1 1 1 Intermediate filament protein DUF4407 PF14362.6 EMC78543.1 - 0.00033 20.1 11.5 0.92 8.8 0.0 3.1 2 1 1 3 3 3 3 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 EMC78543.1 - 0.0033 17.5 1.3 0.0033 17.5 1.3 4.2 3 1 1 4 4 3 1 TPR/MLP1/MLP2-like protein RasGAP_C PF03836.15 EMC78543.1 - 0.037 14.2 12.6 0.46 10.6 2.0 2.9 3 0 0 3 3 3 0 RasGAP C-terminus DivIC PF04977.15 EMC78543.1 - 0.096 12.5 20.1 2.2 8.1 1.8 4.6 4 0 0 4 4 4 0 Septum formation initiator PDGF_N PF04692.13 EMC78543.1 - 0.15 12.9 2.4 0.37 11.6 0.3 2.5 2 0 0 2 2 2 0 Platelet-derived growth factor, N terminal region Prefoldin_2 PF01920.20 EMC78543.1 - 0.42 10.6 20.4 1.1 9.3 0.1 4.5 3 1 1 4 4 4 0 Prefoldin subunit APG6_N PF17675.1 EMC78543.1 - 1.4 9.4 28.3 0.22 12.1 1.9 3.4 3 0 0 3 3 3 0 Apg6 coiled-coil region Phage_Mu_Gam PF07352.12 EMC78543.1 - 1.5 8.7 14.2 5.3 6.9 0.7 4.2 4 1 0 4 4 4 0 Bacteriophage Mu Gam like protein SlyX PF04102.12 EMC78543.1 - 2 9.1 17.2 9.4 6.9 0.6 4.1 4 0 0 4 4 3 0 SlyX YabA PF06156.13 EMC78543.1 - 7 7.3 21.1 0.15 12.7 1.3 4.3 3 1 1 4 4 4 0 Initiation control protein YabA CHDCT2 PF08074.11 EMC78543.1 - 7.5 6.7 8.4 2.4 8.3 1.5 2.5 2 1 0 2 2 2 0 CHDCT2 (NUC038) domain zf-C4H2 PF10146.9 EMC78543.1 - 7.6 6.8 15.1 1.9 8.7 3.4 2.8 1 1 2 3 3 3 0 Zinc finger-containing protein DUF4446 PF14584.6 EMC78543.1 - 8.9 6.3 8.9 2.1 8.3 0.1 3.4 2 1 3 5 5 5 0 Protein of unknown function (DUF4446) Filament PF00038.21 EMC78544.1 - 2.1e-21 76.8 17.0 2.9e-21 76.4 17.0 1.2 1 0 0 1 1 1 1 Intermediate filament protein Mei5 PF10376.9 EMC78544.1 - 0.044 13.6 4.2 0.089 12.6 4.2 1.5 1 0 0 1 1 1 0 Double-strand recombination repair protein FUSC PF04632.12 EMC78544.1 - 0.15 10.6 6.6 0.18 10.3 6.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF1664 PF07889.12 EMC78544.1 - 0.25 11.4 0.1 0.25 11.4 0.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.12 EMC78544.1 - 0.32 11.1 14.1 0.052 13.6 6.3 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein EST1 PF10374.9 EMC78544.1 - 0.33 11.6 2.1 1.3 9.7 1.9 2.0 1 1 0 1 1 1 0 Telomerase activating protein Est1 V_ATPase_I PF01496.19 EMC78544.1 - 0.74 7.7 4.8 0.84 7.5 4.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family BST2 PF16716.5 EMC78544.1 - 2.2 8.9 10.4 0.39 11.3 3.7 2.7 1 1 3 4 4 4 0 Bone marrow stromal antigen 2 UPF0242 PF06785.11 EMC78544.1 - 3.9 7.5 14.7 1.3 9.1 11.8 1.8 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Filament PF00038.21 EMC78545.1 - 4.3e-106 355.0 42.3 4.3e-106 355.0 42.3 1.3 2 0 0 2 2 2 1 Intermediate filament protein TPR_MLP1_2 PF07926.12 EMC78545.1 - 0.0049 16.9 1.5 0.0049 16.9 1.5 4.2 2 2 1 3 3 3 1 TPR/MLP1/MLP2-like protein DUF1664 PF07889.12 EMC78545.1 - 0.047 13.7 31.8 0.72 9.9 0.3 4.8 2 1 3 5 5 5 0 Protein of unknown function (DUF1664) Thump_like PF18096.1 EMC78545.1 - 0.12 12.4 0.0 0.42 10.6 0.0 2.0 1 0 0 1 1 1 0 THUMP domain-like DUF573 PF04504.14 EMC78545.1 - 0.15 12.8 0.4 0.15 12.8 0.4 2.7 3 0 0 3 3 3 0 Protein of unknown function, DUF573 Atg14 PF10186.9 EMC78545.1 - 6 5.9 31.1 2.6 7.1 14.2 3.2 2 2 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Filament PF00038.21 EMC78546.1 - 3.2e-85 286.5 35.9 4e-85 286.1 35.9 1.1 1 0 0 1 1 1 1 Intermediate filament protein ADIP PF11559.8 EMC78546.1 - 0.033 14.3 28.0 0.17 12.0 6.4 3.1 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.9 EMC78546.1 - 0.093 12.7 28.0 0.21 11.6 5.8 4.0 2 2 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Phage_sheath_1C PF17482.2 EMC78546.1 - 0.1 12.6 0.8 0.23 11.4 0.2 1.9 2 0 0 2 2 2 0 Phage tail sheath C-terminal domain DivIC PF04977.15 EMC78546.1 - 3.6 7.4 24.5 2 8.3 0.1 5.5 3 1 2 5 5 5 0 Septum formation initiator Filament PF00038.21 EMC78547.1 - 1.3e-113 379.8 29.0 1.4e-113 379.6 29.0 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.12 EMC78547.1 - 0.00018 21.6 26.3 0.00023 21.2 2.5 3.4 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 EMC78547.1 - 0.0052 17.3 6.7 0.0052 17.3 6.7 3.8 2 2 1 3 3 3 1 Apg6 coiled-coil region DUF4407 PF14362.6 EMC78547.1 - 0.0057 16.0 14.5 0.48 9.7 5.6 3.0 1 1 2 3 3 3 2 Domain of unknown function (DUF4407) Baculo_PEP_C PF04513.12 EMC78547.1 - 0.0062 16.6 9.3 4.4 7.3 2.9 3.6 1 1 2 3 3 3 3 Baculovirus polyhedron envelope protein, PEP, C terminus SPATA1_C PF15743.5 EMC78547.1 - 0.008 16.3 0.4 0.008 16.3 0.4 3.8 2 1 0 3 3 3 1 Spermatogenesis-associated C-terminus DUF1664 PF07889.12 EMC78547.1 - 0.022 14.8 8.6 11 6.1 0.3 4.1 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) BRE1 PF08647.11 EMC78547.1 - 0.022 14.8 20.5 0.081 13.0 2.0 4.2 3 1 1 4 4 4 0 BRE1 E3 ubiquitin ligase Prefoldin_2 PF01920.20 EMC78547.1 - 0.037 14.0 19.1 1.3 9.0 2.7 4.8 4 1 0 4 4 4 0 Prefoldin subunit CENP-F_leu_zip PF10473.9 EMC78547.1 - 0.055 13.5 29.8 3.2 7.8 10.1 4.9 1 1 4 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIC PF04977.15 EMC78547.1 - 0.098 12.4 21.0 0.23 11.2 1.4 5.0 4 1 0 5 5 5 0 Septum formation initiator FlxA PF14282.6 EMC78547.1 - 0.14 12.2 11.9 1.9 8.5 0.5 3.0 2 1 0 2 2 2 0 FlxA-like protein SlyX PF04102.12 EMC78547.1 - 0.49 11.0 21.8 6.1 7.5 1.4 5.0 3 1 2 5 5 5 0 SlyX DUF724 PF05266.14 EMC78547.1 - 0.52 10.1 18.1 0.77 9.6 1.5 3.8 2 2 2 4 4 4 0 Protein of unknown function (DUF724) Fib_alpha PF08702.10 EMC78547.1 - 0.67 10.1 17.4 6.8 6.9 0.8 4.0 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family Phage_GP20 PF06810.11 EMC78547.1 - 0.94 9.3 15.9 1.1 9.0 0.7 3.6 2 2 1 4 4 4 0 Phage minor structural protein GP20 EMP24_GP25L PF01105.24 EMC78547.1 - 2.4 8.1 7.6 4.9 7.0 0.6 2.5 2 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF2203 PF09969.9 EMC78547.1 - 2.4 8.9 11.8 1 10.1 1.3 3.4 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) bZIP_1 PF00170.21 EMC78547.1 - 2.9 8.1 15.6 1.9 8.7 1.8 4.8 4 0 0 4 4 4 0 bZIP transcription factor Sec2p PF06428.11 EMC78547.1 - 3.8 7.6 20.3 0.38 10.7 0.5 4.0 4 0 0 4 4 4 0 GDP/GTP exchange factor Sec2p RasGAP_C PF03836.15 EMC78547.1 - 4.5 7.4 11.3 2.1 8.5 1.2 2.9 1 1 0 2 2 2 0 RasGAP C-terminus Jnk-SapK_ap_N PF09744.9 EMC78547.1 - 4.8 7.4 23.1 1.3 9.2 3.9 3.4 2 2 0 3 3 3 0 JNK_SAPK-associated protein-1 ADIP PF11559.8 EMC78547.1 - 4.8 7.3 22.2 6.2 6.9 1.8 4.2 2 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding DUF4795 PF16043.5 EMC78547.1 - 8.6 5.9 21.7 5.8 6.5 6.7 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) FlaC_arch PF05377.11 EMC78547.1 - 8.9 6.8 16.4 6 7.3 1.0 4.5 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) Filament PF00038.21 EMC78548.1 - 5e-24 85.4 6.6 5.4e-24 85.3 6.6 1.0 1 0 0 1 1 1 1 Intermediate filament protein BRE1 PF08647.11 EMC78548.1 - 0.0012 18.9 1.0 0.0013 18.7 1.0 1.1 1 0 0 1 1 1 1 BRE1 E3 ubiquitin ligase Lebercilin PF15619.6 EMC78548.1 - 0.0099 15.6 3.2 0.01 15.5 3.2 1.0 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease Sec2p PF06428.11 EMC78548.1 - 0.027 14.4 3.0 0.03 14.3 0.3 1.9 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p Filament PF00038.21 EMC78549.1 - 2.6e-48 165.2 22.7 3e-48 165.0 22.7 1.0 1 0 0 1 1 1 1 Intermediate filament protein Transcrip_act PF04949.13 EMC78549.1 - 0.00017 21.5 7.9 0.04 13.8 1.6 2.1 1 1 1 2 2 2 2 Transcriptional activator Phage_GP20 PF06810.11 EMC78549.1 - 0.0019 18.0 5.9 0.0019 18.0 5.9 1.8 1 1 1 2 2 2 1 Phage minor structural protein GP20 AIP3 PF03915.13 EMC78549.1 - 0.0022 17.2 11.7 0.0027 16.9 11.7 1.1 1 0 0 1 1 1 1 Actin interacting protein 3 Gp58 PF07902.11 EMC78549.1 - 0.0026 16.1 9.4 0.0035 15.7 9.4 1.2 1 0 0 1 1 1 1 gp58-like protein EzrA PF06160.12 EMC78549.1 - 0.0028 15.9 12.3 0.0041 15.4 12.3 1.2 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Golgin_A5 PF09787.9 EMC78549.1 - 0.003 17.1 19.6 0.004 16.7 19.6 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 5 Exonuc_VII_L PF02601.15 EMC78549.1 - 0.0046 16.6 9.5 0.0065 16.1 9.5 1.3 1 0 0 1 1 1 1 Exonuclease VII, large subunit Spc7 PF08317.11 EMC78549.1 - 0.0047 15.9 21.6 0.0058 15.6 15.1 2.0 1 1 1 2 2 2 2 Spc7 kinetochore protein GAS PF13851.6 EMC78549.1 - 0.0059 16.0 21.2 0.017 14.4 21.2 1.7 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding Bacillus_HBL PF05791.11 EMC78549.1 - 0.0099 15.7 11.4 0.021 14.7 8.5 2.4 1 1 1 2 2 2 1 Bacillus haemolytic enterotoxin (HBL) Baculo_PEP_C PF04513.12 EMC78549.1 - 0.011 15.8 12.4 0.064 13.3 10.6 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Prominin PF05478.11 EMC78549.1 - 0.025 12.6 10.0 0.029 12.3 10.0 1.1 1 0 0 1 1 1 0 Prominin TSNAXIP1_N PF15739.5 EMC78549.1 - 0.03 14.7 8.1 0.03 14.7 8.1 2.3 1 1 1 2 2 2 0 Translin-associated factor X-interacting N-terminus HMMR_N PF15905.5 EMC78549.1 - 0.036 13.6 20.9 0.049 13.1 20.9 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Atg14 PF10186.9 EMC78549.1 - 0.037 13.1 14.2 0.051 12.6 14.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Lebercilin PF15619.6 EMC78549.1 - 0.045 13.4 22.6 0.062 13.0 22.6 1.1 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Tup_N PF08581.10 EMC78549.1 - 0.083 13.2 26.0 0.089 13.1 10.2 3.7 1 1 2 3 3 3 0 Tup N-terminal Tropomyosin_1 PF12718.7 EMC78549.1 - 0.092 12.9 17.8 0.24 11.5 15.4 2.2 1 1 1 2 2 2 0 Tropomyosin like SKA1 PF07160.12 EMC78549.1 - 0.094 12.6 15.2 0.23 11.3 12.4 2.3 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 DUF2551 PF10826.8 EMC78549.1 - 0.097 12.9 0.9 0.23 11.7 0.1 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2551) CENP-Q PF13094.6 EMC78549.1 - 0.099 12.8 15.7 0.089 13.0 12.6 2.1 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Transposase_22 PF02994.14 EMC78549.1 - 0.15 12.2 6.5 0.17 12.1 1.6 2.3 1 1 1 2 2 2 0 L1 transposable element RBD-like domain Cob_adeno_trans PF01923.18 EMC78549.1 - 0.16 12.1 8.0 0.087 13.0 1.7 2.1 1 1 1 2 2 2 0 Cobalamin adenosyltransferase Laminin_II PF06009.12 EMC78549.1 - 0.16 12.0 10.5 0.35 10.9 10.4 1.6 1 1 0 1 1 1 0 Laminin Domain II Phage_GPO PF05929.11 EMC78549.1 - 0.33 10.5 10.3 0.13 11.9 7.2 1.6 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase ADIP PF11559.8 EMC78549.1 - 0.35 10.9 20.9 0.19 11.8 14.9 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF948 PF06103.11 EMC78549.1 - 0.37 11.1 6.4 1.2 9.4 4.7 2.5 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) APG6_N PF17675.1 EMC78549.1 - 0.37 11.3 25.1 0.19 12.3 20.0 2.0 1 1 1 2 2 2 0 Apg6 coiled-coil region FUSC PF04632.12 EMC78549.1 - 0.41 9.1 2.8 0.46 8.9 2.8 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family CC2-LZ PF16516.5 EMC78549.1 - 0.46 10.9 13.5 0.16 12.3 5.4 2.5 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator FliD_C PF07195.12 EMC78549.1 - 0.46 9.9 9.4 0.68 9.3 8.8 1.6 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus DUF4201 PF13870.6 EMC78549.1 - 0.54 10.0 18.3 1.2 8.8 11.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) DUF1664 PF07889.12 EMC78549.1 - 0.54 10.3 12.7 0.87 9.6 6.4 2.4 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) OmpH PF03938.14 EMC78549.1 - 0.59 10.5 23.3 2.9 8.2 12.1 2.7 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) ATG16 PF08614.11 EMC78549.1 - 0.76 10.0 19.5 9 6.5 18.7 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Fib_alpha PF08702.10 EMC78549.1 - 0.88 9.7 21.0 0.56 10.4 15.4 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family FapA PF03961.13 EMC78549.1 - 0.91 8.0 15.4 0.24 10.0 5.5 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A UPF0242 PF06785.11 EMC78549.1 - 0.97 9.5 24.8 17 5.4 24.8 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Uso1_p115_C PF04871.13 EMC78549.1 - 1 9.8 17.1 15 5.9 17.1 2.4 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Sec2p PF06428.11 EMC78549.1 - 1 9.3 20.1 0.35 10.9 6.0 2.9 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p Lectin_N PF03954.14 EMC78549.1 - 1.1 9.0 12.0 0.71 9.6 4.5 2.6 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain SLATT_6 PF18169.1 EMC78549.1 - 1.3 8.6 7.0 0.49 10.0 0.8 2.3 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 6 T2SSM PF04612.12 EMC78549.1 - 1.4 9.0 13.9 11 6.1 6.9 3.0 2 1 1 3 3 3 0 Type II secretion system (T2SS), protein M V_ATPase_I PF01496.19 EMC78549.1 - 1.4 6.7 12.2 1.3 6.9 11.1 1.3 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family TPR_MLP1_2 PF07926.12 EMC78549.1 - 1.6 8.8 23.8 4.8 7.2 19.2 2.7 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF2203 PF09969.9 EMC78549.1 - 1.7 9.3 12.8 7.5 7.3 5.7 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) HAUS-augmin3 PF14932.6 EMC78549.1 - 1.9 8.0 21.6 0.093 12.3 9.5 2.1 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 POX PF07526.11 EMC78549.1 - 1.9 9.1 10.4 1.1 9.8 8.4 1.7 1 1 0 1 1 1 0 Associated with HOX DUF4559 PF15112.6 EMC78549.1 - 1.9 8.1 12.2 1.5 8.4 11.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4559) DUF724 PF05266.14 EMC78549.1 - 1.9 8.2 15.4 3 7.6 2.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) YabA PF06156.13 EMC78549.1 - 2 9.1 18.1 1.7 9.4 1.3 3.0 1 1 2 3 3 3 0 Initiation control protein YabA NPV_P10 PF05531.12 EMC78549.1 - 2.3 8.7 10.1 6.3 7.3 8.9 2.3 1 1 2 3 3 2 0 Nucleopolyhedrovirus P10 protein BLOC1_2 PF10046.9 EMC78549.1 - 2.4 8.5 17.0 1.7 9.0 8.1 3.4 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 WXG100 PF06013.12 EMC78549.1 - 2.7 8.3 12.5 1.6 9.1 6.2 3.2 1 1 2 3 3 3 0 Proteins of 100 residues with WXG FAM76 PF16046.5 EMC78549.1 - 2.8 7.2 11.0 1.5 8.1 8.5 1.7 1 1 0 1 1 1 0 FAM76 protein Fungal_TACC PF12709.7 EMC78549.1 - 2.9 8.4 15.5 4.6 7.7 1.7 3.0 1 1 2 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins TBCA PF02970.16 EMC78549.1 - 3.3 8.1 15.3 1.4 9.3 2.3 2.6 1 1 2 3 3 3 0 Tubulin binding cofactor A CENP-F_leu_zip PF10473.9 EMC78549.1 - 3.3 7.7 23.9 71 3.4 23.3 2.4 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 COG2 PF06148.11 EMC78549.1 - 3.4 7.7 13.3 59 3.7 13.0 2.5 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Jnk-SapK_ap_N PF09744.9 EMC78549.1 - 3.9 7.7 22.2 56 3.9 22.1 2.1 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Tweety PF04906.13 EMC78549.1 - 4.6 5.8 7.6 5 5.7 6.7 1.5 1 1 0 1 1 1 0 Tweety TMPIT PF07851.13 EMC78549.1 - 5.3 6.2 16.0 3.5 6.8 10.2 1.9 1 1 1 2 2 2 0 TMPIT-like protein DUF16 PF01519.16 EMC78549.1 - 5.8 7.5 17.3 2.4 8.7 10.1 2.5 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF4665 PF15679.5 EMC78549.1 - 7.1 7.3 7.4 13 6.5 3.4 2.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4665) DUF745 PF05335.13 EMC78549.1 - 7.4 6.2 16.3 5.6 6.6 12.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Filament PF00038.21 EMC78550.1 - 3.7e-74 250.1 34.0 2.3e-47 162.1 22.2 2.0 2 0 0 2 2 2 2 Intermediate filament protein Spc7 PF08317.11 EMC78550.1 - 0.0015 17.5 14.6 0.0015 17.5 14.6 2.7 2 1 1 3 3 3 1 Spc7 kinetochore protein ADIP PF11559.8 EMC78550.1 - 0.0015 18.6 11.7 0.0015 18.6 11.7 3.0 2 1 1 3 3 3 1 Afadin- and alpha -actinin-Binding Bacillus_HBL PF05791.11 EMC78550.1 - 0.0059 16.4 3.2 0.0059 16.4 3.2 3.0 2 2 1 3 3 3 1 Bacillus haemolytic enterotoxin (HBL) BAR_3_WASP_bdg PF10456.9 EMC78550.1 - 0.009 15.5 2.8 0.26 10.7 0.1 2.3 2 0 0 2 2 2 1 WASP-binding domain of Sorting nexin protein Tropomyosin_1 PF12718.7 EMC78550.1 - 0.016 15.4 21.0 0.065 13.4 12.8 3.1 2 2 0 2 2 2 0 Tropomyosin like Fungal_TACC PF12709.7 EMC78550.1 - 0.026 15.0 20.6 5.6 7.5 1.2 5.0 2 2 2 5 5 5 0 Fungal Transforming acidic coiled-coil (TACC) proteins DUF4446 PF14584.6 EMC78550.1 - 0.064 13.2 17.2 0.13 12.2 0.3 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF4446) Gp58 PF07902.11 EMC78550.1 - 0.071 11.4 11.5 0.041 12.2 6.9 2.0 2 0 0 2 2 2 0 gp58-like protein Laminin_II PF06009.12 EMC78550.1 - 0.14 12.2 12.2 0.066 13.2 5.9 2.6 2 1 0 2 2 2 0 Laminin Domain II DUF2312 PF10073.9 EMC78550.1 - 0.15 11.8 0.1 0.15 11.8 0.1 3.1 3 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2312) Golgin_A5 PF09787.9 EMC78550.1 - 0.2 11.1 27.4 0.018 14.5 19.7 2.2 2 0 0 2 2 2 0 Golgin subfamily A member 5 Transcrip_act PF04949.13 EMC78550.1 - 0.25 11.2 13.4 0.32 10.9 0.8 2.8 2 1 1 3 3 3 0 Transcriptional activator Lectin_N PF03954.14 EMC78550.1 - 0.26 11.0 12.0 0.39 10.5 2.4 3.3 2 2 1 3 3 3 0 Hepatic lectin, N-terminal domain Phage_GP20 PF06810.11 EMC78550.1 - 0.26 11.1 9.4 0.044 13.6 2.5 2.9 2 2 0 2 2 2 0 Phage minor structural protein GP20 M11L PF11099.8 EMC78550.1 - 0.41 10.9 6.3 0.16 12.3 2.2 2.0 2 0 0 2 2 2 0 Apoptosis regulator M11L like Lebercilin PF15619.6 EMC78550.1 - 0.48 10.1 28.9 0.039 13.6 20.3 2.3 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease T2SSM PF04612.12 EMC78550.1 - 0.52 10.4 12.9 2 8.4 0.0 3.4 3 1 1 4 4 4 0 Type II secretion system (T2SS), protein M Atg14 PF10186.9 EMC78550.1 - 0.65 9.0 17.9 0.3 10.1 10.3 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 POX PF07526.11 EMC78550.1 - 0.86 10.2 12.0 0.57 10.8 6.5 2.3 2 0 0 2 2 2 0 Associated with HOX FlxA PF14282.6 EMC78550.1 - 0.88 9.6 21.9 4.8 7.2 16.3 2.9 2 0 0 2 2 2 0 FlxA-like protein WEMBL PF05701.11 EMC78550.1 - 0.89 8.2 18.4 0.15 10.7 12.1 2.0 2 0 0 2 2 2 0 Weak chloroplast movement under blue light CENP-Q PF13094.6 EMC78550.1 - 1.6 8.9 21.0 0.095 12.9 12.0 2.9 2 2 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF1664 PF07889.12 EMC78550.1 - 1.9 8.5 13.8 0.62 10.1 4.9 3.1 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 EMC78550.1 - 2 8.6 26.7 0.72 10.0 13.1 3.1 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family SOAR PF16533.5 EMC78550.1 - 2.2 8.3 12.9 3.2 7.8 0.6 3.7 2 1 2 4 4 4 0 STIM1 Orai1-activating region SlyX PF04102.12 EMC78550.1 - 2.3 8.9 30.2 1.5 9.5 0.6 5.2 2 2 3 5 5 5 0 SlyX FAM76 PF16046.5 EMC78550.1 - 2.4 7.4 8.9 0.36 10.2 3.8 2.1 2 0 0 2 2 2 0 FAM76 protein Cob_adeno_trans PF01923.18 EMC78550.1 - 2.9 8.0 8.4 0.38 10.9 2.0 2.5 2 1 1 3 3 3 0 Cobalamin adenosyltransferase CENP-F_leu_zip PF10473.9 EMC78550.1 - 3 7.9 31.2 1e+02 2.9 22.9 4.3 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 WXG100 PF06013.12 EMC78550.1 - 3.6 7.9 11.3 1.6 9.0 3.6 3.8 2 2 1 3 3 3 0 Proteins of 100 residues with WXG DUF4407 PF14362.6 EMC78550.1 - 3.9 6.7 12.9 48 3.1 12.9 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF16 PF01519.16 EMC78550.1 - 4.2 7.9 20.1 0.18 12.3 7.5 3.3 2 2 1 3 3 3 0 Protein of unknown function DUF16 V_ATPase_I PF01496.19 EMC78550.1 - 4.3 5.1 17.4 0.34 8.8 11.0 1.9 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF948 PF06103.11 EMC78550.1 - 5 7.4 5.6 12 6.2 0.5 3.6 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Phage_GPO PF05929.11 EMC78550.1 - 5.1 6.6 10.3 0.34 10.5 4.1 2.0 2 1 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase YabA PF06156.13 EMC78550.1 - 6.1 7.5 28.4 18 6.1 1.0 4.9 1 1 4 5 5 5 0 Initiation control protein YabA FapA PF03961.13 EMC78550.1 - 6.3 5.3 22.6 3.8 6.0 0.6 3.0 1 1 1 3 3 3 0 Flagellar Assembly Protein A DUF848 PF05852.11 EMC78550.1 - 6.4 6.9 12.9 0.89 9.7 4.4 3.1 2 2 2 4 4 4 0 Gammaherpesvirus protein of unknown function (DUF848) HMMR_N PF15905.5 EMC78550.1 - 8.4 5.8 27.5 0.37 10.2 17.7 2.2 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Filament PF00038.21 EMC78551.1 - 1.4e-100 336.9 34.7 1.6e-100 336.7 34.7 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.12 EMC78551.1 - 8e-09 35.6 30.8 7.4e-07 29.3 0.1 3.9 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein Golgin_A5 PF09787.9 EMC78551.1 - 5.7e-05 22.7 27.8 0.0093 15.5 20.4 2.4 1 1 1 2 2 2 2 Golgin subfamily A member 5 DUF4407 PF14362.6 EMC78551.1 - 0.00062 19.2 14.0 0.49 9.7 9.4 3.2 1 1 2 3 3 3 2 Domain of unknown function (DUF4407) Spc7 PF08317.11 EMC78551.1 - 0.0019 17.1 15.5 0.0019 17.1 15.5 3.5 1 1 1 4 4 4 1 Spc7 kinetochore protein Phage_GP20 PF06810.11 EMC78551.1 - 0.0032 17.3 3.1 0.0032 17.3 3.1 3.3 2 2 0 2 2 2 1 Phage minor structural protein GP20 Transcrip_act PF04949.13 EMC78551.1 - 0.0039 17.1 12.1 0.15 12.0 3.4 2.8 2 1 1 3 3 3 2 Transcriptional activator Tropomyosin_1 PF12718.7 EMC78551.1 - 0.016 15.3 28.5 0.022 14.9 13.6 3.8 2 1 1 3 3 3 0 Tropomyosin like CEP63 PF17045.5 EMC78551.1 - 0.031 14.2 28.5 0.076 12.9 23.2 2.2 2 0 0 2 2 2 0 Centrosomal protein of 63 kDa Laminin_II PF06009.12 EMC78551.1 - 0.035 14.1 16.9 0.063 13.3 7.4 3.3 2 1 1 3 3 3 0 Laminin Domain II GAS PF13851.6 EMC78551.1 - 0.069 12.5 34.8 0.65 9.3 19.1 3.9 1 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Lectin_N PF03954.14 EMC78551.1 - 0.23 11.2 17.3 0.58 9.9 1.6 3.7 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain CENP-F_leu_zip PF10473.9 EMC78551.1 - 0.24 11.4 39.3 1.1 9.3 23.2 4.4 2 2 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Exonuc_VII_L PF02601.15 EMC78551.1 - 0.28 10.7 21.4 0.042 13.4 11.3 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit ADIP PF11559.8 EMC78551.1 - 0.28 11.3 31.2 0.11 12.5 12.9 4.3 2 2 2 4 4 4 0 Afadin- and alpha -actinin-Binding Gp58 PF07902.11 EMC78551.1 - 0.3 9.3 14.0 0.32 9.2 12.1 1.9 1 1 0 1 1 1 0 gp58-like protein FapA PF03961.13 EMC78551.1 - 0.35 9.4 24.2 3.2 6.2 3.1 3.1 1 1 2 3 3 3 0 Flagellar Assembly Protein A Vps5 PF09325.10 EMC78551.1 - 0.36 10.4 16.7 0.34 10.4 2.5 3.1 2 1 1 3 3 3 0 Vps5 C terminal like UPF0242 PF06785.11 EMC78551.1 - 0.37 10.9 33.9 0.4 10.8 2.1 2.9 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus AAA_13 PF13166.6 EMC78551.1 - 0.39 9.3 20.1 0.44 9.1 15.9 2.1 1 1 1 2 2 2 0 AAA domain Phage_Mu_Gam PF07352.12 EMC78551.1 - 0.39 10.6 20.5 7.1 6.5 0.1 4.5 3 1 1 4 4 4 0 Bacteriophage Mu Gam like protein MCPsignal PF00015.21 EMC78551.1 - 0.48 10.2 4.8 1.9 8.3 3.7 2.4 2 1 1 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Atg14 PF10186.9 EMC78551.1 - 0.71 8.9 22.4 8.6 5.3 18.7 2.8 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4446 PF14584.6 EMC78551.1 - 0.96 9.4 21.5 0.89 9.5 0.3 4.0 3 2 1 4 4 4 0 Protein of unknown function (DUF4446) Bacillus_HBL PF05791.11 EMC78551.1 - 0.98 9.2 16.6 0.077 12.8 6.4 3.4 2 1 2 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) PspA_IM30 PF04012.12 EMC78551.1 - 1.1 8.7 25.1 2.1 7.9 1.0 4.3 2 1 2 4 4 4 0 PspA/IM30 family WEMBL PF05701.11 EMC78551.1 - 1.2 7.8 22.1 4.2 5.9 17.1 2.9 1 1 0 2 2 2 0 Weak chloroplast movement under blue light Jnk-SapK_ap_N PF09744.9 EMC78551.1 - 1.5 9.0 33.4 4.9 7.4 1.0 3.9 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 EzrA PF06160.12 EMC78551.1 - 2 6.5 32.7 0.16 10.1 15.2 3.7 1 1 1 3 3 3 0 Septation ring formation regulator, EzrA HMMR_N PF15905.5 EMC78551.1 - 2.2 7.7 34.5 7.1 6.0 27.6 2.6 1 1 2 3 3 3 0 Hyaluronan mediated motility receptor N-terminal DUF948 PF06103.11 EMC78551.1 - 2.5 8.4 13.3 1.7 9.0 0.7 4.5 2 1 4 6 6 6 0 Bacterial protein of unknown function (DUF948) DUF725 PF05267.12 EMC78551.1 - 2.6 8.0 7.4 18 5.4 4.8 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF725) Phage_GPO PF05929.11 EMC78551.1 - 3.4 7.2 12.2 0.59 9.7 7.0 2.2 2 1 1 3 3 2 0 Phage capsid scaffolding protein (GPO) serine peptidase BLOC1_2 PF10046.9 EMC78551.1 - 3.4 8.0 27.0 4.5 7.6 7.1 5.4 4 1 3 7 7 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fib_alpha PF08702.10 EMC78551.1 - 3.6 7.8 30.5 1.4 9.1 13.9 4.1 2 2 2 4 4 4 0 Fibrinogen alpha/beta chain family Baculo_PEP_C PF04513.12 EMC78551.1 - 3.7 7.6 21.4 3.2 7.8 2.5 3.7 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Cob_adeno_trans PF01923.18 EMC78551.1 - 3.9 7.6 11.6 0.54 10.4 1.6 3.3 1 1 2 3 3 3 0 Cobalamin adenosyltransferase WXG100 PF06013.12 EMC78551.1 - 4.9 7.5 14.1 0.72 10.1 2.5 4.1 4 1 1 5 5 3 0 Proteins of 100 residues with WXG DUF4200 PF13863.6 EMC78551.1 - 5.7 7.4 28.6 3.1 8.2 0.1 4.1 2 2 1 3 3 3 0 Domain of unknown function (DUF4200) DUF641 PF04859.12 EMC78551.1 - 5.9 7.2 23.3 22 5.4 9.9 4.2 2 2 2 4 4 4 0 Plant protein of unknown function (DUF641) DUF724 PF05266.14 EMC78551.1 - 6.3 6.6 22.9 7 6.4 1.6 3.5 1 1 1 3 3 3 0 Protein of unknown function (DUF724) DUF2203 PF09969.9 EMC78551.1 - 6.7 7.5 17.8 17 6.2 4.8 4.0 1 1 2 4 4 4 0 Uncharacterized conserved protein (DUF2203) DUF848 PF05852.11 EMC78551.1 - 6.9 6.8 18.1 8.2 6.5 9.3 4.1 2 1 0 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) ApoO PF09769.9 EMC78551.1 - 6.9 6.6 11.5 23 5.0 1.6 4.1 3 1 2 5 5 5 0 Apolipoprotein O DUF1664 PF07889.12 EMC78551.1 - 7.2 6.7 20.0 4.5 7.3 5.2 4.5 2 1 4 6 6 6 0 Protein of unknown function (DUF1664) FliJ PF02050.16 EMC78551.1 - 9.3 6.5 34.0 18 5.6 0.2 4.2 3 1 1 4 4 4 0 Flagellar FliJ protein HAD_2 PF13419.6 EMC78551.1 - 9.9 6.2 9.1 3.9 7.5 0.2 2.7 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Filament PF00038.21 EMC78552.1 - 2.2e-99 333.0 41.2 2.5e-99 332.8 41.2 1.0 1 0 0 1 1 1 1 Intermediate filament protein Spc7 PF08317.11 EMC78552.1 - 0.002 17.1 14.5 0.002 17.1 14.5 3.4 1 1 1 2 2 2 1 Spc7 kinetochore protein ADIP PF11559.8 EMC78552.1 - 0.002 18.2 11.6 0.002 18.2 11.6 4.1 2 2 2 4 4 4 1 Afadin- and alpha -actinin-Binding TPR_MLP1_2 PF07926.12 EMC78552.1 - 0.0021 18.1 2.3 0.0021 18.1 2.3 4.0 3 1 0 3 3 3 1 TPR/MLP1/MLP2-like protein Bacillus_HBL PF05791.11 EMC78552.1 - 0.012 15.5 3.8 0.012 15.5 3.8 3.9 1 1 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) GAS PF13851.6 EMC78552.1 - 0.014 14.7 38.4 0.69 9.2 4.1 4.1 2 2 1 3 3 3 0 Growth-arrest specific micro-tubule binding DUF4407 PF14362.6 EMC78552.1 - 0.05 12.9 15.1 0.79 9.0 0.9 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Golgin_A5 PF09787.9 EMC78552.1 - 0.051 13.0 37.9 0.087 12.3 21.6 2.8 1 1 1 3 3 3 0 Golgin subfamily A member 5 M11L PF11099.8 EMC78552.1 - 0.084 13.2 2.5 0.22 11.8 2.5 1.7 1 0 0 1 1 1 0 Apoptosis regulator M11L like Death PF00531.22 EMC78552.1 - 0.086 13.0 0.1 0.086 13.0 0.1 3.3 2 1 0 3 3 3 0 Death domain CENP-F_leu_zip PF10473.9 EMC78552.1 - 0.14 12.2 46.8 0.34 10.9 8.5 4.8 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4200 PF13863.6 EMC78552.1 - 0.3 11.5 0.2 0.3 11.5 0.2 4.5 2 2 0 3 3 3 0 Domain of unknown function (DUF4200) T2SSM PF04612.12 EMC78552.1 - 0.32 11.0 12.4 2.5 8.2 0.0 3.5 3 1 1 4 4 4 0 Type II secretion system (T2SS), protein M Lectin_N PF03954.14 EMC78552.1 - 0.38 10.5 18.9 0.63 9.8 2.6 4.1 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain Fungal_TACC PF12709.7 EMC78552.1 - 0.69 10.4 31.5 3.6 8.1 0.5 6.0 3 2 1 5 5 5 0 Fungal Transforming acidic coiled-coil (TACC) proteins Gp58 PF07902.11 EMC78552.1 - 0.88 7.8 14.2 0.14 10.4 9.7 1.9 1 1 0 1 1 1 0 gp58-like protein WXG100 PF06013.12 EMC78552.1 - 1.5 9.1 11.0 1.5 9.1 3.4 4.0 2 2 0 2 2 2 0 Proteins of 100 residues with WXG Syntaxin-6_N PF09177.11 EMC78552.1 - 2.1 8.9 22.6 4.6 7.8 0.5 4.0 2 2 1 3 3 3 0 Syntaxin 6, N-terminal WEMBL PF05701.11 EMC78552.1 - 2.6 6.6 28.0 1.2 7.7 18.1 2.5 3 0 0 3 3 3 0 Weak chloroplast movement under blue light Tropomyosin_1 PF12718.7 EMC78552.1 - 3 8.0 34.8 0.19 11.9 13.8 3.9 1 1 2 3 3 3 0 Tropomyosin like Fib_alpha PF08702.10 EMC78552.1 - 3.9 7.7 31.9 1.2 9.3 13.4 4.0 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family HAD_2 PF13419.6 EMC78552.1 - 5.1 7.1 12.3 2.8 8.0 0.4 2.8 2 2 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Cob_adeno_trans PF01923.18 EMC78552.1 - 6.4 6.9 10.9 0.39 10.8 1.9 2.9 1 1 2 3 3 3 0 Cobalamin adenosyltransferase Phage_GPO PF05929.11 EMC78552.1 - 6.4 6.3 14.1 3.5 7.2 8.5 2.5 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase FapA PF03961.13 EMC78552.1 - 9.2 4.7 29.1 2.4 6.7 0.8 3.3 1 1 2 3 3 3 0 Flagellar Assembly Protein A Filament PF00038.21 EMC78553.1 - 6.4e-104 347.9 25.6 7.1e-104 347.7 25.6 1.0 1 0 0 1 1 1 1 Intermediate filament protein CENP-F_leu_zip PF10473.9 EMC78553.1 - 1e-05 25.6 31.1 0.00029 20.9 5.4 4.9 3 2 1 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.12 EMC78553.1 - 2e-05 24.6 25.8 2.2e-05 24.5 0.6 3.8 3 1 0 3 3 3 1 TPR/MLP1/MLP2-like protein Nsp1_C PF05064.13 EMC78553.1 - 0.00091 19.0 6.4 0.00091 19.0 6.4 3.5 2 2 1 3 3 3 1 Nsp1-like C-terminal region SPATA1_C PF15743.5 EMC78553.1 - 0.0021 18.1 16.4 0.061 13.4 0.1 3.0 2 1 0 2 2 2 1 Spermatogenesis-associated C-terminus ADIP PF11559.8 EMC78553.1 - 0.0079 16.3 27.7 0.16 12.0 1.0 4.2 3 1 1 4 4 4 2 Afadin- and alpha -actinin-Binding DUF5344 PF17279.2 EMC78553.1 - 0.014 16.0 10.6 0.27 11.9 3.0 4.1 2 2 2 4 4 4 0 Family of unknown function (DUF5344) RasGAP_C PF03836.15 EMC78553.1 - 0.016 15.3 14.4 0.36 11.0 0.2 3.2 2 1 1 3 3 3 0 RasGAP C-terminus SKA1 PF07160.12 EMC78553.1 - 0.028 14.3 14.0 0.76 9.6 2.0 3.4 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 1 DUF4200 PF13863.6 EMC78553.1 - 0.04 14.3 17.2 0.16 12.4 0.3 3.5 2 2 2 4 4 4 0 Domain of unknown function (DUF4200) Spc7 PF08317.11 EMC78553.1 - 0.044 12.7 26.4 0.053 12.4 14.5 2.8 1 1 1 2 2 2 0 Spc7 kinetochore protein Baculo_PEP_C PF04513.12 EMC78553.1 - 0.047 13.7 15.8 0.21 11.7 7.6 3.5 2 1 0 3 3 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus UPF0242 PF06785.11 EMC78553.1 - 0.25 11.4 19.9 1.1 9.3 12.8 2.4 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF4140 PF13600.6 EMC78553.1 - 0.44 11.0 16.0 2.5 8.6 2.1 4.0 3 1 1 4 4 4 0 N-terminal domain of unknown function (DUF4140) DUF745 PF05335.13 EMC78553.1 - 0.45 10.2 11.2 3 7.5 7.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF745) Fungal_TACC PF12709.7 EMC78553.1 - 0.48 10.9 17.4 3.2 8.2 0.4 4.9 4 2 1 5 5 5 0 Fungal Transforming acidic coiled-coil (TACC) proteins Tropomyosin_1 PF12718.7 EMC78553.1 - 0.64 10.2 22.7 0.78 9.9 9.3 3.4 3 1 0 3 3 3 0 Tropomyosin like FlaC_arch PF05377.11 EMC78553.1 - 0.72 10.3 13.1 5.5 7.5 0.3 5.0 4 2 0 4 4 4 0 Flagella accessory protein C (FlaC) Golgin_A5 PF09787.9 EMC78553.1 - 0.75 9.2 25.6 0.83 9.1 13.7 2.7 1 1 1 2 2 2 0 Golgin subfamily A member 5 TBCC_N PF16752.5 EMC78553.1 - 0.87 10.0 9.4 3.9 7.9 2.5 3.0 3 1 1 4 4 3 0 Tubulin-specific chaperone C N-terminal domain DUF4407 PF14362.6 EMC78553.1 - 0.96 8.7 18.4 2.5 7.4 4.5 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) DUF4510 PF14971.6 EMC78553.1 - 1.2 9.4 8.4 0.21 11.9 1.9 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4510) Bacillus_HBL PF05791.11 EMC78553.1 - 1.9 8.3 8.0 0.45 10.3 2.5 2.6 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) CREPT PF16566.5 EMC78553.1 - 2 8.6 21.8 0.042 14.0 7.0 3.4 3 2 1 4 4 4 0 Cell-cycle alteration and expression-elevated protein in tumour Uso1_p115_C PF04871.13 EMC78553.1 - 2.4 8.5 20.1 0.15 12.4 6.5 3.1 2 1 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region APG6_N PF17675.1 EMC78553.1 - 2.5 8.6 33.5 0.42 11.1 3.0 4.1 2 2 2 4 4 4 0 Apg6 coiled-coil region She9_MDM33 PF05546.11 EMC78553.1 - 2.7 7.8 12.3 6.9 6.4 0.8 3.6 2 2 1 3 3 3 0 She9 / Mdm33 family TolA_bind_tri PF16331.5 EMC78553.1 - 2.8 8.1 29.9 0.14 12.3 3.3 5.0 4 1 1 5 5 5 0 TolA binding protein trimerisation Prefoldin_2 PF01920.20 EMC78553.1 - 3.2 7.8 27.6 0.75 9.8 1.9 5.0 4 1 2 6 6 5 0 Prefoldin subunit PI3K_P85_iSH2 PF16454.5 EMC78553.1 - 3.4 7.2 23.2 1.1 8.8 1.7 3.9 3 1 1 4 4 4 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF1664 PF07889.12 EMC78553.1 - 4 7.5 13.5 3.5 7.7 1.2 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) TMF_DNA_bd PF12329.8 EMC78553.1 - 4.8 7.3 13.9 12 6.0 0.2 4.6 3 1 1 4 4 4 0 TATA element modulatory factor 1 DNA binding KELK PF15796.5 EMC78553.1 - 5 7.6 16.0 0.083 13.4 4.2 3.5 3 1 1 4 4 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Jnk-SapK_ap_N PF09744.9 EMC78553.1 - 5.4 7.2 30.2 0.25 11.6 2.5 3.6 2 2 1 4 4 4 0 JNK_SAPK-associated protein-1 DUF641 PF04859.12 EMC78553.1 - 5.8 7.3 17.7 1.4 9.3 0.7 3.7 2 2 2 4 4 4 0 Plant protein of unknown function (DUF641) SlyX PF04102.12 EMC78553.1 - 6.2 7.5 25.1 0.24 12.0 2.4 4.8 4 1 1 5 5 4 0 SlyX BRE1 PF08647.11 EMC78553.1 - 9.1 6.4 18.3 0.25 11.4 0.4 4.2 3 2 1 4 4 3 0 BRE1 E3 ubiquitin ligase Filament PF00038.21 EMC78554.1 - 3.2e-108 362.0 23.4 3.6e-108 361.8 23.4 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.12 EMC78554.1 - 3e-05 24.1 23.7 0.00022 21.3 0.7 3.3 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.9 EMC78554.1 - 4.1e-05 23.6 31.1 0.0028 17.7 12.5 4.9 3 2 1 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SPATA1_C PF15743.5 EMC78554.1 - 0.0011 19.1 16.4 0.093 12.8 0.0 3.0 2 1 0 2 2 2 1 Spermatogenesis-associated C-terminus Nsp1_C PF05064.13 EMC78554.1 - 0.0044 16.8 7.0 0.0044 16.8 7.0 3.2 2 2 1 3 3 3 1 Nsp1-like C-terminal region Baculo_PEP_C PF04513.12 EMC78554.1 - 0.0046 17.0 6.6 0.0091 16.0 0.4 2.8 3 0 0 3 3 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus KELK PF15796.5 EMC78554.1 - 0.021 15.2 5.6 0.021 15.2 5.6 3.1 3 0 0 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase ADIP PF11559.8 EMC78554.1 - 0.036 14.2 25.5 0.24 11.5 1.3 4.2 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding Prefoldin_2 PF01920.20 EMC78554.1 - 0.04 13.9 23.4 0.69 9.9 2.0 4.9 5 1 0 5 5 4 0 Prefoldin subunit Spc7 PF08317.11 EMC78554.1 - 0.05 12.5 24.3 0.071 12.0 13.6 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein CCDC144C PF14915.6 EMC78554.1 - 0.072 12.2 22.9 0.047 12.8 0.7 3.6 3 1 1 4 4 4 0 CCDC144C protein coiled-coil region gp45-slide_C PF09116.10 EMC78554.1 - 0.14 12.3 0.1 4.6 7.4 0.0 2.4 2 0 0 2 2 2 0 gp45 sliding clamp, C terminal APG6_N PF17675.1 EMC78554.1 - 0.17 12.4 27.1 0.12 12.9 0.7 3.8 3 1 1 4 4 4 0 Apg6 coiled-coil region DUF4140 PF13600.6 EMC78554.1 - 0.19 12.2 15.6 5.7 7.4 2.0 3.9 3 1 1 4 4 4 0 N-terminal domain of unknown function (DUF4140) DUF4407 PF14362.6 EMC78554.1 - 0.19 11.0 15.2 2.3 7.5 4.6 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) DUF4200 PF13863.6 EMC78554.1 - 0.23 11.9 16.2 0.58 10.6 0.3 3.3 2 2 1 3 3 3 0 Domain of unknown function (DUF4200) DUF4510 PF14971.6 EMC78554.1 - 0.3 11.4 7.3 0.046 14.1 1.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4510) Tropomyosin_1 PF12718.7 EMC78554.1 - 0.41 10.8 19.9 1.8 8.7 8.6 3.5 3 1 0 3 3 3 0 Tropomyosin like Bacillus_HBL PF05791.11 EMC78554.1 - 0.54 10.1 6.2 0.17 11.7 1.5 2.4 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF5344 PF17279.2 EMC78554.1 - 0.55 10.8 6.6 24 5.6 2.6 3.4 2 2 1 3 3 3 0 Family of unknown function (DUF5344) Fungal_TACC PF12709.7 EMC78554.1 - 0.58 10.6 16.8 1.3 9.5 2.4 4.7 4 2 1 5 5 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins SlyX PF04102.12 EMC78554.1 - 0.76 10.4 24.4 0.53 10.9 2.8 4.7 4 1 1 5 5 4 0 SlyX Phage_GP20 PF06810.11 EMC78554.1 - 0.77 9.5 11.9 3.9 7.3 4.9 3.8 2 2 0 2 2 2 0 Phage minor structural protein GP20 Sec2p PF06428.11 EMC78554.1 - 1.1 9.3 23.8 0.05 13.6 3.0 4.1 3 2 1 4 4 3 0 GDP/GTP exchange factor Sec2p Gp58 PF07902.11 EMC78554.1 - 1.3 7.2 6.5 5 5.3 6.3 1.7 1 1 0 1 1 1 0 gp58-like protein LXG PF04740.12 EMC78554.1 - 1.5 8.5 6.5 0.61 9.8 3.3 1.9 2 0 0 2 2 2 0 LXG domain of WXG superfamily Cortex-I_coil PF09304.10 EMC78554.1 - 1.6 9.0 16.8 15 5.8 1.3 3.9 3 1 0 3 3 3 0 Cortexillin I, coiled coil DUF641 PF04859.12 EMC78554.1 - 1.7 9.0 17.0 1.5 9.1 0.8 3.5 2 2 1 3 3 3 0 Plant protein of unknown function (DUF641) Golgin_A5 PF09787.9 EMC78554.1 - 1.8 8.0 23.9 2.5 7.5 13.3 2.6 1 1 2 3 3 3 0 Golgin subfamily A member 5 FlxA PF14282.6 EMC78554.1 - 2 8.4 20.7 0.46 10.5 9.8 3.7 2 2 0 3 3 3 0 FlxA-like protein FliJ PF02050.16 EMC78554.1 - 2.1 8.6 17.2 0.52 10.6 8.8 3.2 3 0 0 3 3 3 0 Flagellar FliJ protein Mt_ATP-synt_D PF05873.12 EMC78554.1 - 2.1 8.2 3.9 2.9 7.7 0.1 2.8 2 2 2 4 4 4 0 ATP synthase D chain, mitochondrial (ATP5H) DivIC PF04977.15 EMC78554.1 - 2.8 7.8 19.7 6.6 6.6 0.2 5.0 5 0 0 5 5 5 0 Septum formation initiator Uso1_p115_C PF04871.13 EMC78554.1 - 3.1 8.2 18.7 0.034 14.5 3.3 3.1 3 1 1 4 4 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF745 PF05335.13 EMC78554.1 - 3.3 7.4 10.6 16 5.2 6.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Jnk-SapK_ap_N PF09744.9 EMC78554.1 - 5.4 7.2 28.3 1.7 8.9 5.4 3.3 2 1 2 4 4 4 0 JNK_SAPK-associated protein-1 SKA1 PF07160.12 EMC78554.1 - 6.8 6.5 16.0 3.7 7.3 1.1 3.3 1 1 1 3 3 3 0 Spindle and kinetochore-associated protein 1 RasGAP_C PF03836.15 EMC78554.1 - 8.1 6.6 13.0 0.42 10.7 0.2 3.0 2 1 1 3 3 3 0 RasGAP C-terminus DHR10 PF18595.1 EMC78554.1 - 8.8 6.4 27.0 1.7 8.7 2.2 3.3 3 1 0 3 3 3 0 Designed helical repeat protein 10 domain Swi5 PF07061.11 EMC78554.1 - 9.2 6.4 10.1 5.4 7.2 0.4 3.9 4 0 0 4 4 3 0 Swi5 Filament PF00038.21 EMC78555.1 - 2.7e-24 86.3 4.7 2.9e-24 86.2 4.7 1.0 1 0 0 1 1 1 1 Intermediate filament protein Med29 PF11568.8 EMC78555.1 - 0.01 16.1 0.2 0.029 14.6 0.2 1.7 1 1 1 2 2 2 0 Mediator complex subunit 29 BRE1 PF08647.11 EMC78555.1 - 0.013 15.6 0.6 0.016 15.2 0.4 1.3 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase TolA_bind_tri PF16331.5 EMC78555.1 - 0.015 15.3 2.8 0.022 14.8 2.8 1.4 1 1 0 1 1 1 0 TolA binding protein trimerisation HalX PF08663.10 EMC78555.1 - 0.039 14.3 2.1 0.05 13.9 1.1 1.6 1 1 1 2 2 2 0 HalX domain ABC_tran_CTD PF16326.5 EMC78555.1 - 0.065 13.5 5.3 0.43 10.9 5.3 2.0 1 1 0 1 1 1 0 ABC transporter C-terminal domain SKA1 PF07160.12 EMC78555.1 - 0.081 12.8 1.6 0.094 12.6 1.6 1.1 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 FlxA PF14282.6 EMC78555.1 - 0.13 12.3 1.7 0.17 11.9 1.7 1.3 1 0 0 1 1 1 0 FlxA-like protein DUF4407 PF14362.6 EMC78555.1 - 0.14 11.5 1.1 0.16 11.3 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3498 PF12004.8 EMC78555.1 - 0.36 10.0 5.6 0.42 9.8 5.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3498) Nsp1_C PF05064.13 EMC78555.1 - 1.4 8.7 5.6 1.7 8.5 0.3 2.0 1 1 1 2 2 2 0 Nsp1-like C-terminal region Sugarporin_N PF11471.8 EMC78555.1 - 1.5 8.8 5.2 5.5 7.0 0.1 2.5 2 1 1 3 3 3 0 Maltoporin periplasmic N-terminal extension Filament PF00038.21 EMC78556.1 - 3.5e-73 246.9 7.4 3.9e-73 246.7 7.4 1.0 1 0 0 1 1 1 1 Intermediate filament protein Fungal_TACC PF12709.7 EMC78556.1 - 0.031 14.7 5.6 3.5 8.1 1.4 3.3 3 0 0 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins MADF_DNA_bdg PF10545.9 EMC78556.1 - 0.036 14.4 0.7 0.37 11.2 0.1 2.6 2 1 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like NTP_transf_8 PF12281.8 EMC78556.1 - 0.048 13.7 0.1 0.076 13.0 0.1 1.3 1 0 0 1 1 1 0 Nucleotidyltransferase Spc7 PF08317.11 EMC78556.1 - 0.22 10.4 10.1 0.065 12.1 3.0 2.5 3 0 0 3 3 3 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 EMC78556.1 - 0.39 10.7 16.7 1.5 8.8 4.7 3.4 3 2 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TSNAXIP1_N PF15739.5 EMC78556.1 - 0.52 10.7 5.9 0.43 11.0 3.2 2.1 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus SlyX PF04102.12 EMC78556.1 - 0.53 10.9 10.8 1.4 9.6 2.3 4.0 4 1 1 5 5 5 0 SlyX Prefoldin_2 PF01920.20 EMC78556.1 - 9.5 6.2 12.5 9 6.3 4.1 3.7 4 1 0 4 4 4 0 Prefoldin subunit Filament PF00038.21 EMC78557.1 - 1.4e-109 366.4 27.8 8.2e-109 364.0 27.8 1.9 1 1 0 1 1 1 1 Intermediate filament protein Peptidase_Mx PF15887.5 EMC78557.1 - 0.049 13.0 0.2 0.096 12.1 0.2 1.4 1 0 0 1 1 1 0 Putative zinc-binding metallo-peptidase SlyX PF04102.12 EMC78557.1 - 0.053 14.1 21.4 2.3 8.9 0.3 5.6 4 1 1 5 5 5 0 SlyX DUF4407 PF14362.6 EMC78557.1 - 0.074 12.4 17.4 1 8.7 3.7 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) DUF5082 PF16888.5 EMC78557.1 - 0.55 10.5 18.2 1.2 9.4 0.4 4.4 3 2 1 4 4 4 0 Domain of unknown function (DUF5082) Keratin_2_head PF16208.5 EMC78557.1 - 1.3 9.1 46.2 2.8 8.1 46.2 1.5 1 0 0 1 1 1 0 Keratin type II head Atg14 PF10186.9 EMC78557.1 - 1.6 7.7 18.7 1.2 8.1 1.0 3.2 2 2 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4510 PF14971.6 EMC78557.1 - 4 7.8 8.7 0.21 11.9 0.7 2.8 3 2 0 3 3 3 0 Domain of unknown function (DUF4510) DUF1664 PF07889.12 EMC78557.1 - 5.9 7.0 14.8 13 5.9 0.3 4.4 2 1 2 5 5 5 0 Protein of unknown function (DUF1664) RasGAP_C PF03836.15 EMC78557.1 - 6.7 6.9 15.2 9.3 6.4 0.4 3.3 2 1 0 3 3 3 0 RasGAP C-terminus DUF4446 PF14584.6 EMC78557.1 - 7.1 6.6 11.5 3.4 7.6 0.1 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF4446) ADIP PF11559.8 EMC78557.1 - 8.8 6.4 24.9 0.73 9.9 4.2 4.0 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding WXG100 PF06013.12 EMC78557.1 - 9.4 6.6 9.9 3.9 7.8 0.7 3.8 2 1 2 4 4 4 0 Proteins of 100 residues with WXG SUI1 PF01253.22 EMC78558.1 - 1.9e-29 102.0 0.8 2.2e-29 101.8 0.8 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF2729 PF10870.8 EMC78558.1 - 0.058 13.3 0.3 0.14 12.1 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2729) Milton PF12448.8 EMC78559.1 - 7.9e-06 26.1 0.1 1e-05 25.7 0.1 1.2 1 0 0 1 1 1 1 Kinesin associated protein Arm PF00514.23 EMC78560.1 - 7.2e-45 149.7 18.6 1.3e-09 37.8 0.1 10.9 12 0 0 12 12 12 5 Armadillo/beta-catenin-like repeat HEAT PF02985.22 EMC78560.1 - 1.6e-09 37.2 5.6 0.16 12.3 0.0 6.9 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.6 EMC78560.1 - 5.6e-07 29.9 12.7 1.2 9.7 0.0 7.9 8 1 1 9 9 9 3 HEAT-like repeat HEAT_2 PF13646.6 EMC78560.1 - 1.2e-06 28.8 9.6 0.0016 18.8 0.7 5.7 4 2 0 5 5 5 1 HEAT repeats V-ATPase_H_N PF03224.14 EMC78560.1 - 4.2e-06 26.3 0.9 0.061 12.6 0.1 3.3 2 1 0 3 3 3 2 V-ATPase subunit H Cnd1 PF12717.7 EMC78560.1 - 9.5e-06 25.7 2.7 0.00095 19.2 0.3 3.3 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EMC78560.1 - 1.4e-05 23.9 7.1 0.0014 17.3 0.6 2.9 2 1 0 2 2 2 2 Adaptin N terminal region Atx10homo_assoc PF09759.9 EMC78560.1 - 0.00082 19.4 2.6 0.019 15.0 0.1 4.2 5 1 1 6 6 6 1 Spinocerebellar ataxia type 10 protein domain RasGEF_N_2 PF14663.6 EMC78560.1 - 0.0011 19.4 5.8 3.9 7.9 0.1 4.8 4 1 1 5 5 5 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain PUL PF08324.11 EMC78560.1 - 0.0027 17.0 0.2 0.0027 17.0 0.2 2.2 2 1 0 2 2 2 1 PUL domain Arm_2 PF04826.13 EMC78560.1 - 0.0032 17.0 3.2 1.3 8.4 0.1 4.3 3 2 1 4 4 4 1 Armadillo-like DUF3361 PF11841.8 EMC78560.1 - 0.0039 17.1 5.1 0.19 11.7 0.2 4.2 2 2 3 5 5 5 1 Domain of unknown function (DUF3361) UMPH-1 PF05822.12 EMC78561.1 - 6.1e-121 402.6 0.4 7.1e-121 402.4 0.4 1.0 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD PF12710.7 EMC78561.1 - 8.9e-06 26.2 0.0 2.1e-05 25.0 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 EMC78561.1 - 0.0087 15.5 0.5 0.051 13.0 0.1 2.2 2 1 0 2 2 2 1 Putative Phosphatase DNA_photolyase PF00875.18 EMC78561.1 - 0.12 12.3 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 DNA photolyase Kelch_1 PF01344.25 EMC78562.1 - 3.1e-76 250.7 15.6 2.7e-16 58.9 0.8 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EMC78562.1 - 3.2e-44 147.8 6.3 8.1e-10 38.6 0.0 6.3 2 1 4 6 6 6 6 Kelch motif Kelch_2 PF07646.15 EMC78562.1 - 6.4e-31 105.1 2.8 6.4e-05 22.8 0.0 6.9 7 0 0 7 7 7 6 Kelch motif BACK PF07707.15 EMC78562.1 - 1.9e-29 101.8 0.2 3.4e-29 101.0 0.2 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.31 EMC78562.1 - 1.5e-28 99.2 0.1 4.7e-28 97.6 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain Kelch_3 PF13415.6 EMC78562.1 - 8.1e-28 96.1 10.7 1.6e-05 25.1 0.0 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_4 PF13418.6 EMC78562.1 - 4.8e-25 87.3 3.9 0.00029 20.8 0.0 5.7 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC78562.1 - 4.4e-15 55.3 14.8 0.017 15.1 0.3 6.5 6 0 0 6 6 6 6 Kelch motif BCS1_N PF08740.11 EMC78562.1 - 0.16 12.0 0.0 0.86 9.6 0.0 2.0 2 0 0 2 2 2 0 BCS1 N terminal TPR_12 PF13424.6 EMC78563.1 - 1.8e-13 50.6 2.8 5.4e-06 26.6 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EMC78563.1 - 1e-09 38.3 1.9 1.5e-09 37.7 1.9 1.1 1 0 0 1 1 1 1 MalT-like TPR region TPR_8 PF13181.6 EMC78563.1 - 1.3e-08 34.4 7.5 0.01 16.0 0.2 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 EMC78563.1 - 1.5e-08 34.1 2.8 0.1 12.7 0.0 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 EMC78563.1 - 1.2e-07 31.2 5.8 0.16 11.8 0.2 4.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 EMC78563.1 - 4.2e-07 29.6 6.2 0.061 13.5 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EMC78563.1 - 0.0013 19.2 9.5 2.1 9.1 0.1 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMC78563.1 - 0.0025 17.5 0.1 1.3 8.7 0.0 3.1 2 0 0 2 2 2 1 TPR repeat RPN7 PF10602.9 EMC78563.1 - 0.0096 15.6 0.3 0.029 14.1 0.3 1.9 1 1 0 1 1 1 1 26S proteasome subunit RPN7 DDE_Tnp_1_3 PF13612.6 EMC78563.1 - 0.065 13.2 0.1 0.17 11.9 0.1 1.7 1 0 0 1 1 1 0 Transposase DDE domain ANAPC3 PF12895.7 EMC78563.1 - 0.091 13.0 0.5 16 5.8 0.6 2.5 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 EMC78564.1 - 8.8e-43 142.4 28.5 1.5e-06 27.7 0.0 9.0 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 EMC78564.1 - 5.7e-40 132.2 21.9 6e-06 26.0 1.6 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat DnaJ PF00226.31 EMC78564.1 - 3.6e-24 84.7 2.4 3.6e-24 84.7 2.4 2.4 2 0 0 2 2 2 1 DnaJ domain TPR_8 PF13181.6 EMC78564.1 - 6.9e-22 75.8 17.3 0.0028 17.7 0.3 9.1 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.6 EMC78564.1 - 1e-17 64.3 12.0 0.011 16.2 0.2 6.4 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 EMC78564.1 - 1.9e-16 59.4 22.1 8.6e-07 28.5 4.7 7.7 6 1 2 8 8 7 3 TPR repeat TPR_12 PF13424.6 EMC78564.1 - 2e-16 60.0 18.3 2.1e-05 24.7 1.3 6.7 4 2 2 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 EMC78564.1 - 1.2e-15 57.9 5.3 0.00044 20.8 0.0 5.8 3 3 2 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 EMC78564.1 - 1.6e-14 53.1 17.0 4.4e-05 23.6 0.1 7.7 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 EMC78564.1 - 6.5e-12 45.2 7.8 0.1 13.5 0.0 8.4 7 2 3 10 10 8 2 Tetratricopeptide repeat TPR_9 PF13371.6 EMC78564.1 - 3.3e-09 36.8 8.3 0.15 12.2 0.2 5.7 3 3 3 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 EMC78564.1 - 3.7e-08 32.8 10.4 0.14 12.3 0.4 7.5 7 1 0 8 8 7 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMC78564.1 - 6.3e-08 32.8 13.7 0.2 12.4 0.7 6.6 6 0 0 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC78564.1 - 1.3e-07 31.7 26.0 0.00086 19.5 0.3 5.7 2 2 3 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EMC78564.1 - 7.1e-05 22.5 12.5 0.56 10.1 0.3 5.8 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_4 PF07721.14 EMC78564.1 - 0.0028 18.1 0.4 1.8 9.4 0.0 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat NFACT-R_1 PF05670.13 EMC78564.1 - 0.0083 16.8 0.1 0.021 15.5 0.1 1.7 1 0 0 1 1 1 1 NFACT protein RNA binding domain Fis1_TPR_C PF14853.6 EMC78564.1 - 0.035 14.2 9.8 13 5.9 0.1 5.8 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat Rapsyn_N PF10579.9 EMC78564.1 - 0.039 14.0 0.5 15 5.8 0.0 3.7 3 0 0 3 3 3 0 Rapsyn N-terminal myristoylation and linker region RPT PF13446.6 EMC78564.1 - 0.045 13.7 0.2 0.22 11.5 0.0 2.3 2 0 0 2 2 1 0 A repeated domain in UCH-protein MtrB PF05440.12 EMC78564.1 - 0.18 12.3 0.0 0.41 11.1 0.0 1.6 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase subunit B Alkyl_sulf_dimr PF14863.6 EMC78564.1 - 0.32 11.5 11.7 9.1 6.7 0.1 4.8 4 1 1 5 5 5 0 Alkyl sulfatase dimerisation BTAD PF03704.17 EMC78564.1 - 0.72 10.3 11.1 14 6.1 0.2 4.3 1 1 2 4 4 4 0 Bacterial transcriptional activator domain Sel1 PF08238.12 EMC78564.1 - 0.74 10.6 3.6 6.7 7.6 0.4 3.7 3 0 0 3 3 3 0 Sel1 repeat MIT PF04212.18 EMC78564.1 - 1 9.5 23.8 1.3 9.1 2.2 5.8 4 2 2 6 6 5 0 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.9 EMC78564.1 - 3.6 7.1 8.5 7.8 6.0 0.1 5.1 7 0 0 7 7 7 0 SHNi-TPR RPN7 PF10602.9 EMC78564.1 - 4.4 7.0 13.9 0.64 9.7 4.0 3.3 2 1 0 2 2 2 0 26S proteasome subunit RPN7 TPR_3 PF07720.12 EMC78564.1 - 8.6 6.5 13.0 0.45 10.6 4.3 3.4 4 0 0 4 4 3 0 Tetratricopeptide repeat Ras PF00071.22 EMC78565.1 - 3.2e-26 91.9 0.4 3.6e-26 91.7 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC78565.1 - 1.6e-11 44.5 0.3 3.5e-11 43.4 0.1 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC78565.1 - 3.9e-08 32.9 0.1 5e-08 32.6 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC78565.1 - 5.9e-06 26.0 0.2 0.00068 19.2 0.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EMC78565.1 - 8.4e-06 25.8 0.0 1.1e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EMC78565.1 - 0.00014 22.0 0.8 0.00044 20.3 0.9 2.0 1 1 0 1 1 1 1 Dynamin family DUF2121 PF09894.9 EMC78565.1 - 0.0011 18.5 0.4 0.012 15.1 0.0 2.3 2 1 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2121) RsgA_GTPase PF03193.16 EMC78565.1 - 0.0013 18.6 0.6 0.77 9.6 0.1 2.1 2 0 0 2 2 2 2 RsgA GTPase G-alpha PF00503.20 EMC78565.1 - 0.039 13.1 1.0 1.5 7.9 0.1 2.4 1 1 1 2 2 2 0 G-protein alpha subunit DUF2677 PF10838.8 EMC78565.1 - 0.091 12.7 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2677) UPF0113 PF03657.13 EMC78565.1 - 0.092 13.0 0.2 0.39 11.0 0.0 2.0 2 0 0 2 2 2 0 UPF0113 PUA domain AAA_16 PF13191.6 EMC78565.1 - 0.11 12.8 0.2 0.26 11.6 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain Gtr1_RagA PF04670.12 EMC78565.1 - 0.16 11.3 1.0 0.33 10.3 1.0 1.5 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region LRAT PF04970.13 EMC78567.1 - 2.2e-05 24.7 3.2 0.0069 16.7 0.1 2.1 1 1 1 2 2 2 2 Lecithin retinol acyltransferase Peptidase_C92 PF05708.12 EMC78567.1 - 0.11 12.6 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family NLPC_P60 PF00877.19 EMC78567.1 - 0.12 12.5 0.1 0.33 11.0 0.1 1.8 1 1 0 1 1 1 0 NlpC/P60 family Hormone_recep PF00104.30 EMC78568.1 - 6.8e-31 107.5 0.1 2.6e-30 105.6 0.1 1.8 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 EMC78568.1 - 3.9e-28 97.7 14.2 4.5e-28 97.5 12.5 1.9 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Peptidase_C48 PF02902.19 EMC78569.1 - 1.2e-12 48.2 0.3 6e-12 45.9 0.3 2.1 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain PK_C PF02887.16 EMC78570.1 - 2e-34 118.3 0.0 2.6e-34 118.0 0.0 1.1 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain Biotin_lipoyl PF00364.22 EMC78571.1 - 3.4e-21 74.8 2.5 4e-21 74.6 2.5 1.1 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EMC78571.1 - 3.3e-11 42.8 0.0 7.5e-05 22.5 0.0 2.1 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD_3 PF13437.6 EMC78571.1 - 3.6e-05 24.4 0.1 0.0061 17.2 0.1 2.0 1 1 1 2 2 2 1 HlyD family secretion protein HlyD_D23 PF16576.5 EMC78571.1 - 0.00013 21.2 0.2 0.033 13.4 0.0 2.0 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion RnfC_N PF13375.6 EMC78571.1 - 0.0011 18.8 1.8 0.0023 17.9 1.8 1.6 1 1 0 1 1 1 1 RnfC Barrel sandwich hybrid domain PYNP_C PF07831.13 EMC78571.1 - 0.003 17.2 0.2 1.6 8.4 0.0 2.1 1 1 1 2 2 2 2 Pyrimidine nucleoside phosphorylase C-terminal domain PTS_EIIA_1 PF00358.20 EMC78571.1 - 0.0035 17.1 0.1 0.82 9.4 0.0 2.1 1 1 1 2 2 2 2 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 PASTA PF03793.19 EMC78571.1 - 0.0049 16.7 0.1 0.078 12.8 0.1 2.1 2 0 0 2 2 2 1 PASTA domain GCV_H PF01597.19 EMC78571.1 - 0.018 14.9 0.2 0.022 14.7 0.2 1.2 1 0 0 1 1 1 0 Glycine cleavage H-protein Peptidase_M23 PF01551.22 EMC78571.1 - 0.07 13.3 0.4 1.5 9.1 0.1 2.2 1 1 0 1 1 1 0 Peptidase family M23 NQRA PF05896.11 EMC78571.1 - 0.12 11.8 0.5 0.14 11.6 0.3 1.3 1 1 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) YqfD PF06898.11 EMC78571.1 - 0.22 10.3 1.6 1.7 7.4 1.1 2.0 1 1 0 1 1 1 0 Putative stage IV sporulation protein YqfD GGACT PF06094.12 EMC78572.1 - 3.6e-22 79.2 0.2 4.1e-22 79.0 0.2 1.1 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 EMC78572.1 - 0.089 13.2 0.0 0.19 12.2 0.0 1.5 1 0 0 1 1 1 0 AIG2-like family TPR_1 PF00515.28 EMC78573.1 - 2.1e-34 115.9 19.1 5.9e-05 22.7 0.1 7.6 7 0 0 7 7 7 7 Tetratricopeptide repeat DUF1736 PF08409.11 EMC78573.1 - 1.5e-33 114.6 3.7 3.1e-33 113.6 3.7 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1736) TPR_2 PF07719.17 EMC78573.1 - 3.5e-29 98.5 17.3 1.1e-05 25.1 0.3 7.7 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.6 EMC78573.1 - 1.2e-27 93.8 9.7 5.7e-05 23.0 0.2 7.6 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.6 EMC78573.1 - 1.3e-26 91.0 20.9 6.2e-06 26.2 0.3 7.9 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_16 PF13432.6 EMC78573.1 - 1.3e-24 86.5 5.7 1.1e-07 32.3 0.1 4.8 3 1 1 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 EMC78573.1 - 1.5e-24 85.4 17.6 2.3e-06 27.2 0.3 8.0 2 2 6 8 8 8 5 TPR repeat TPR_12 PF13424.6 EMC78573.1 - 9.1e-19 67.5 13.8 1.5e-06 28.4 0.2 5.9 2 2 4 6 6 6 6 Tetratricopeptide repeat TPR_14 PF13428.6 EMC78573.1 - 4.6e-16 58.1 8.3 0.0045 17.7 0.1 8.1 3 1 6 9 9 7 5 Tetratricopeptide repeat TPR_10 PF13374.6 EMC78573.1 - 1.9e-14 53.0 22.1 5.7e-05 22.8 0.5 7.5 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 EMC78573.1 - 8.6e-14 51.8 9.7 2.5e-06 27.9 0.9 5.3 1 1 5 6 6 6 5 Tetratricopeptide repeat TPR_7 PF13176.6 EMC78573.1 - 4.1e-10 39.0 5.3 4.6 7.5 0.0 7.0 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_4 PF07721.14 EMC78573.1 - 7.5e-05 23.0 0.3 3.8 8.4 0.0 5.1 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 EMC78573.1 - 0.00026 20.3 7.4 0.011 15.0 1.1 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EMC78573.1 - 0.00032 20.2 4.6 0.12 11.7 0.3 3.3 1 1 2 3 3 3 2 MalT-like TPR region NARP1 PF12569.8 EMC78573.1 - 0.0019 17.2 3.1 0.05 12.5 0.2 2.6 1 1 1 3 3 3 1 NMDA receptor-regulated protein 1 TPR_6 PF13174.6 EMC78573.1 - 0.0039 17.7 3.2 16 6.4 0.0 5.2 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 EMC78573.1 - 0.0099 16.0 4.8 0.11 12.6 0.1 3.4 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_20 PF14561.6 EMC78573.1 - 0.052 13.9 2.9 1 9.7 0.1 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.17 EMC78573.1 - 0.14 12.6 1.8 0.85 10.1 0.1 2.3 2 0 0 2 2 2 0 Bacterial transcriptional activator domain FAT PF02259.23 EMC78573.1 - 0.18 11.0 5.3 0.03 13.6 1.4 1.7 2 0 0 2 2 2 0 FAT domain ANAPC3 PF12895.7 EMC78573.1 - 0.41 10.9 5.5 3.2 8.1 0.4 2.9 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.18 EMC78573.1 - 4.9 7.3 5.8 14 5.8 0.8 3.8 3 2 1 4 4 3 0 MIT (microtubule interacting and transport) domain EGF_2 PF07974.13 EMC78575.1 - 1.4e-41 140.5 213.7 6.2e-08 32.9 16.8 11.0 9 3 3 12 12 12 9 EGF-like domain I-EGF_1 PF18372.1 EMC78575.1 - 3.8e-06 26.9 197.9 0.0084 16.2 11.7 13.0 14 1 1 15 15 15 9 Integrin beta epidermal growth factor like domain 1 FGF PF00167.18 EMC78576.1 - 2.8e-16 59.7 0.2 3.6e-16 59.4 0.2 1.1 1 0 0 1 1 1 1 Fibroblast growth factor Ion_trans PF00520.31 EMC78577.1 - 2.2e-35 122.1 10.0 3e-35 121.6 10.0 1.2 1 0 0 1 1 1 1 Ion transport protein PAS_9 PF13426.7 EMC78577.1 - 3.9e-18 65.6 0.1 8.4e-18 64.5 0.1 1.5 1 0 0 1 1 1 1 PAS domain cNMP_binding PF00027.29 EMC78577.1 - 1.3e-14 54.1 0.0 2.3e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 EMC78577.1 - 4.6e-12 45.7 3.5 4.6e-12 45.7 3.5 2.2 3 0 0 3 3 3 1 Ion channel PAS PF00989.25 EMC78577.1 - 9.6e-07 28.8 0.0 2.9e-06 27.3 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.12 EMC78577.1 - 2.8e-05 24.3 0.0 5.5e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EMC78577.1 - 0.016 15.4 0.0 0.036 14.3 0.0 1.6 1 0 0 1 1 1 0 PAS fold Cupin_3 PF05899.12 EMC78577.1 - 0.02 14.6 0.7 0.048 13.4 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF861) Cupin_2 PF07883.11 EMC78577.1 - 0.02 14.6 0.1 0.055 13.2 0.1 1.7 1 0 0 1 1 1 0 Cupin domain PI3K_1B_p101 PF10486.9 EMC78578.1 - 8.3 4.0 13.2 8.1 4.1 13.2 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RD3 PF14473.6 EMC78579.1 - 1.1e-49 167.7 2.7 1.5e-49 167.1 2.7 1.2 1 0 0 1 1 1 1 RD3 protein Acyltransf_C PF16076.5 EMC78581.1 - 3.9e-16 58.9 0.1 1e-15 57.6 0.0 1.7 2 0 0 2 2 2 1 Acyltransferase C-terminus Acyltransferase PF01553.21 EMC78581.1 - 0.051 13.2 0.0 0.076 12.6 0.0 1.3 1 0 0 1 1 1 0 Acyltransferase DUF4517 PF15006.6 EMC78582.1 - 2.4e-50 170.8 0.0 2.8e-50 170.5 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4517) Ig_2 PF13895.6 EMC78583.1 - 6.6e-49 164.2 0.6 4.3e-13 49.4 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin domain Ig_3 PF13927.6 EMC78583.1 - 3.9e-46 155.6 5.1 2e-11 44.3 0.0 5.7 6 0 0 6 6 6 5 Immunoglobulin domain I-set PF07679.16 EMC78583.1 - 8.2e-40 134.8 0.4 1.7e-08 34.4 0.1 7.3 5 3 1 6 6 6 5 Immunoglobulin I-set domain ig PF00047.25 EMC78583.1 - 8.7e-30 102.7 4.0 6.7e-06 26.2 0.1 7.0 7 2 0 7 7 7 5 Immunoglobulin domain V-set PF07686.17 EMC78583.1 - 1.8e-24 86.0 1.8 0.022 14.9 0.0 8.3 5 3 3 8 8 8 7 Immunoglobulin V-set domain Ig_4 PF16680.5 EMC78583.1 - 1.5e-15 57.2 0.0 0.012 15.8 0.0 5.1 5 0 0 5 5 5 3 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 EMC78583.1 - 3.2e-14 53.1 0.0 0.013 15.9 0.2 5.4 5 1 0 5 5 5 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 EMC78583.1 - 3.3e-13 49.5 0.0 0.039 14.0 0.0 5.3 5 0 0 5 5 5 3 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 EMC78583.1 - 1.8e-10 40.2 0.1 0.025 14.2 0.0 5.5 5 1 1 6 6 6 2 Immunoglobulin domain C1-set PF07654.15 EMC78583.1 - 7.9e-08 32.6 0.0 0.67 10.4 0.0 4.2 3 1 0 3 3 3 3 Immunoglobulin C1-set domain C2-set PF05790.15 EMC78583.1 - 0.00015 21.9 0.0 1.7 8.9 0.0 5.2 7 0 0 7 7 7 1 Immunoglobulin C2-set domain C2-set_2 PF08205.12 EMC78583.1 - 0.00021 21.3 5.9 0.91 9.6 0.0 5.2 6 0 0 6 6 6 1 CD80-like C2-set immunoglobulin domain PKD_3 PF16820.5 EMC78583.1 - 0.002 17.9 0.0 4.2 7.2 0.0 3.9 4 0 0 4 4 4 1 PKD-like domain BiPBP_C PF06832.12 EMC78583.1 - 0.011 15.8 0.1 0.51 10.4 0.0 3.3 3 1 0 3 3 3 0 Penicillin-Binding Protein C-terminus Family RGI_lyase PF18370.1 EMC78583.1 - 0.017 15.4 0.1 0.67 10.3 0.0 2.8 3 0 0 3 3 3 0 Rhamnogalacturonan I lyases beta-sheet domain Ig_2 PF13895.6 EMC78584.1 - 6.4e-13 48.8 0.0 7.8e-13 48.6 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC78584.1 - 2.4e-11 44.1 0.0 4.1e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC78584.1 - 1.1e-07 31.9 0.0 6.9e-07 29.2 0.0 1.9 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC78584.1 - 1.8e-07 31.2 0.0 4e-07 30.1 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC78584.1 - 9.6e-05 22.5 0.1 0.093 12.9 0.0 2.0 1 1 1 2 2 2 2 Immunoglobulin V-set domain Ig_4 PF16680.5 EMC78584.1 - 0.00027 21.1 0.0 0.00032 20.9 0.0 1.1 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 EMC78584.1 - 0.0015 18.9 0.0 0.0019 18.5 0.0 1.1 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Homeodomain PF00046.29 EMC78585.1 - 2.6e-13 49.6 2.4 3.1e-13 49.3 2.4 1.1 1 0 0 1 1 1 1 Homeodomain HTH_AsnC-type PF13404.6 EMC78585.1 - 0.043 13.6 0.0 0.1 12.5 0.0 1.7 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain ATP-synt_ab PF00006.25 EMC78587.1 - 2.5e-63 213.6 0.0 3.4e-63 213.1 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EMC78587.1 - 3.6e-09 37.0 0.2 6.5e-09 36.2 0.2 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain RNA_capsid PF03035.14 EMC78588.1 - 0.055 13.5 0.0 0.098 12.7 0.0 1.3 1 0 0 1 1 1 0 Calicivirus putative RNA polymerase/capsid protein ATG16 PF08614.11 EMC78588.1 - 1.4 9.1 18.4 4.9 7.3 7.6 2.3 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) FAD-oxidase_C PF02913.19 EMC78588.1 - 2.6 7.6 4.8 2.3 7.8 0.3 2.4 2 0 0 2 2 2 0 FAD linked oxidases, C-terminal domain PAM2 PF07145.15 EMC78589.1 - 8.1e-07 28.3 0.2 8.1e-07 28.3 0.2 1.8 2 0 0 2 2 2 1 Ataxin-2 C-terminal region PT PF04886.12 EMC78590.1 - 5.6e-17 61.0 104.0 1.8e+04 -48.3 104.0 4.1 1 1 0 1 1 1 0 PT repeat C2 PF00168.30 EMC78591.1 - 8.7e-78 257.2 0.0 4.3e-17 62.3 0.0 6.9 7 0 0 7 7 7 6 C2 domain FerB PF08150.12 EMC78591.1 - 3.5e-32 110.8 0.0 1.1e-31 109.2 0.0 2.0 1 0 0 1 1 1 1 FerB (NUC096) domain Ferlin_C PF16165.5 EMC78591.1 - 1.8e-26 92.9 1.7 3e-22 79.2 0.1 2.6 1 1 1 2 2 2 2 Ferlin C-terminus FerA PF08165.11 EMC78591.1 - 1.2e-20 73.2 0.5 3.1e-20 71.9 0.5 1.8 1 0 0 1 1 1 1 FerA (NUC095) domain FerI PF08151.12 EMC78591.1 - 5.8e-20 71.1 0.1 1.4e-19 69.9 0.1 1.7 1 0 0 1 1 1 1 FerI (NUC094) domain Pex24p PF06398.11 EMC78591.1 - 1.7e-05 24.0 5.4 1.7e-05 24.0 5.4 3.7 3 1 1 4 4 4 2 Integral peroxisomal membrane peroxin PTEN_C2 PF10409.9 EMC78591.1 - 0.0011 18.7 0.0 0.0029 17.4 0.0 1.6 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DUF4726 PF15855.5 EMC78591.1 - 0.031 14.5 1.4 0.085 13.1 1.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4726) Synaptobrevin PF00957.21 EMC78591.1 - 1.9 8.3 3.6 4.3 7.2 3.6 1.6 1 0 0 1 1 1 0 Synaptobrevin CCSAP PF15748.5 EMC78593.1 - 0.0003 21.1 35.4 0.00034 20.9 35.4 1.1 1 0 0 1 1 1 1 Centriole, cilia and spindle-associated Presenilin PF01080.17 EMC78593.1 - 0.02 13.6 29.1 0.024 13.4 29.1 1.1 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 EMC78593.1 - 0.092 11.8 26.9 0.11 11.6 26.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Nop14 PF04147.12 EMC78593.1 - 0.1 10.8 44.2 0.12 10.6 44.2 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EMC78593.1 - 0.15 10.3 41.4 0.18 10.0 41.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4045 PF13254.6 EMC78593.1 - 0.19 11.3 31.2 0.22 11.1 31.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) NPR3 PF03666.13 EMC78593.1 - 0.28 9.9 33.5 0.42 9.4 33.5 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 TFIIF_alpha PF05793.12 EMC78593.1 - 0.33 9.5 61.1 0.44 9.1 61.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Hid1 PF12722.7 EMC78593.1 - 0.51 8.4 24.7 0.57 8.2 24.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF262 PF03235.14 EMC78593.1 - 0.71 10.0 18.9 0.92 9.6 18.9 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 SAPS PF04499.15 EMC78593.1 - 1.1 8.0 26.9 1.4 7.6 26.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SID-1_RNA_chan PF13965.6 EMC78593.1 - 1.6 7.0 11.4 2.1 6.7 11.4 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Endostatin PF06482.11 EMC78593.1 - 1.9 7.9 13.3 2.5 7.5 13.3 1.4 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin XRN_M PF17846.1 EMC78593.1 - 3.3 6.6 26.7 3.9 6.3 26.7 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Menin PF05053.13 EMC78593.1 - 3.8 5.7 13.4 5.1 5.3 13.4 1.3 1 0 0 1 1 1 0 Menin CDC27 PF09507.10 EMC78593.1 - 4.1 6.7 55.4 6.6 6.0 55.4 1.4 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Raftlin PF15250.6 EMC78593.1 - 7 5.3 23.9 8.3 5.0 23.9 1.1 1 0 0 1 1 1 0 Raftlin CBP_BcsG PF11658.8 EMC78593.1 - 7.2 4.9 6.5 9.2 4.5 6.5 1.3 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Smg8_Smg9 PF10220.9 EMC78593.1 - 7.2 4.8 23.5 8.5 4.5 23.5 1.1 1 0 0 1 1 1 0 Smg8_Smg9 DUF5427 PF10310.9 EMC78593.1 - 9 5.1 36.4 12 4.7 36.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5427) BTB PF00651.31 EMC78594.1 - 1.9e-27 95.7 2.0 6e-13 49.0 0.0 3.6 4 0 0 4 4 4 3 BTB/POZ domain Ras PF00071.22 EMC78594.1 - 4.3e-23 81.7 0.0 8.5e-23 80.7 0.0 1.5 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EMC78594.1 - 2.6e-09 37.3 0.0 5.6e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase zf-RING_4 PF14570.6 EMC78594.1 - 0.1 12.4 3.4 0.29 10.9 3.4 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain SR-25 PF10500.9 EMC78594.1 - 1.9 8.1 13.0 3.1 7.3 13.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF755 PF05501.11 EMC78594.1 - 8.5 6.7 13.2 20 5.5 13.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Death PF00531.22 EMC78595.1 - 4.6e-16 58.8 0.2 7.2e-16 58.1 0.2 1.2 1 0 0 1 1 1 1 Death domain TNFR_c6 PF00020.18 EMC78595.1 - 1.3e-08 35.0 22.1 4.8e-08 33.3 16.0 4.2 4 1 0 4 4 4 2 TNFR/NGFR cysteine-rich region Tweety PF04906.13 EMC78595.1 - 0.29 9.8 4.2 0.15 10.7 2.2 1.4 2 0 0 2 2 2 0 Tweety Snf7 PF03357.21 EMC78596.1 - 1.3e-23 83.5 5.4 1.3e-23 83.5 5.4 2.0 1 1 1 2 2 2 1 Snf7 PspA_IM30 PF04012.12 EMC78596.1 - 1.1e-05 25.1 0.5 1.1e-05 25.1 0.5 2.0 2 0 0 2 2 2 1 PspA/IM30 family DUF763 PF05559.11 EMC78596.1 - 0.11 11.7 1.3 0.18 10.9 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF763) Fez1 PF06818.15 EMC78596.1 - 0.13 12.7 9.5 0.8 10.1 9.5 2.1 1 1 1 2 2 2 0 Fez1 Citrate_synt PF00285.21 EMC78596.1 - 0.14 11.2 0.4 5.2 6.0 0.0 2.1 1 1 1 2 2 2 0 Citrate synthase, C-terminal domain Fmp27_WPPW PF10359.9 EMC78596.1 - 0.4 9.5 4.0 0.54 9.0 3.5 1.3 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Snapin_Pallidin PF14712.6 EMC78596.1 - 2 8.9 10.5 1 9.8 2.9 3.2 3 1 0 3 3 3 0 Snapin/Pallidin RUN PF02759.19 EMC78596.1 - 3.8 7.4 5.9 11 6.0 0.2 3.0 2 1 0 2 2 2 0 RUN domain 7tm_1 PF00001.21 EMC78597.1 - 8.3e-73 244.9 11.4 9.7e-73 244.7 11.4 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC78597.1 - 9.1e-10 38.3 11.5 3e-09 36.6 11.5 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 EMC78597.1 - 1.2e-08 34.7 4.4 1.6e-08 34.2 4.4 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 EMC78597.1 - 6.7e-08 32.5 7.1 6.7e-08 32.5 7.1 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC78597.1 - 0.0019 18.0 2.5 0.0019 18.0 2.5 1.8 2 0 0 2 2 2 1 Olfactory receptor tRNA-synt_2 PF00152.20 EMC78597.1 - 0.052 12.6 0.0 0.094 11.8 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class II (D, K and N) zf-LITAF-like PF10601.9 EMC78597.1 - 2.5 8.4 9.8 3.4 8.0 0.9 3.4 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain R3H PF01424.22 EMC78598.1 - 4.1e-13 49.1 0.1 6.7e-13 48.4 0.1 1.4 1 0 0 1 1 1 1 R3H domain NCBP3 PF10309.9 EMC78598.1 - 0.00047 19.9 0.0 0.00087 19.1 0.0 1.4 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 MPTase-PolyVal PF18818.1 EMC78598.1 - 0.045 13.8 0.0 0.087 12.9 0.0 1.4 1 0 0 1 1 1 0 Metallopeptidase superfamily domain SRCR PF00530.18 EMC78599.1 - 1.9e-87 288.3 30.4 5e-29 100.7 4.3 4.1 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 EMC78599.1 - 2.6e-23 82.4 12.8 1.9e-05 25.1 0.2 4.4 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 EMC78599.1 - 1.1e-15 58.1 6.5 0.0025 18.3 0.0 4.6 4 0 0 4 4 4 4 Hepsin, SRCR domain Drf_FH1 PF06346.12 EMC78600.1 - 0.063 13.0 39.5 0.16 11.7 39.5 1.6 1 1 0 1 1 1 0 Formin Homology Region 1 GDA1_CD39 PF01150.17 EMC78601.1 - 1.1e-07 30.9 0.0 1.3e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family DUF2207 PF09972.9 EMC78601.1 - 0.045 12.5 0.0 0.047 12.4 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Mito_carr PF00153.27 EMC78602.1 - 8.3e-11 41.7 0.0 1.2e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial carrier protein RebB PF11747.8 EMC78602.1 - 0.12 12.5 0.0 0.18 11.9 0.0 1.2 1 0 0 1 1 1 0 Killing trait DUF543 PF04418.12 EMC78602.1 - 0.14 12.2 0.0 0.26 11.3 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF543) Homeodomain PF00046.29 EMC78603.1 - 9.8e-21 73.4 6.9 1.4e-20 72.8 6.9 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC78603.1 - 0.015 15.1 0.2 0.03 14.2 0.2 1.4 1 0 0 1 1 1 0 Homeobox KN domain Homeodomain PF00046.29 EMC78604.1 - 2.3e-21 75.4 5.7 3.2e-21 74.9 5.7 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC78604.1 - 0.014 15.3 0.2 0.024 14.6 0.2 1.4 1 0 0 1 1 1 0 Homeobox KN domain Homez PF11569.8 EMC78604.1 - 0.021 14.3 0.2 0.03 13.8 0.2 1.3 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Stanniocalcin PF03298.13 EMC78605.1 - 6.1e-101 335.8 5.7 7.1e-101 335.6 5.7 1.0 1 0 0 1 1 1 1 Stanniocalcin family Reprolysin PF01421.19 EMC78606.1 - 4.8e-30 105.0 2.5 4.8e-30 105.0 2.5 2.1 2 0 0 2 2 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 EMC78606.1 - 3.7e-22 78.9 8.8 3.7e-22 78.9 8.8 4.1 3 2 0 3 3 1 1 ADAM cysteine-rich Disintegrin PF00200.23 EMC78606.1 - 1.8e-19 70.3 34.0 1.8e-19 70.3 34.0 4.1 4 0 0 4 4 4 1 Disintegrin Reprolysin_2 PF13574.6 EMC78606.1 - 1.9e-08 34.4 0.2 4.6e-08 33.2 0.2 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 EMC78606.1 - 5.2e-08 33.4 0.3 5.2e-08 33.4 0.3 1.7 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EMC78606.1 - 1.1e-07 32.2 0.8 1.1e-07 32.2 0.8 2.8 3 0 0 3 3 2 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 EMC78606.1 - 5.7e-06 26.1 0.1 1e-05 25.3 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 EMC78606.1 - 0.0019 17.8 0.0 0.0039 16.8 0.0 1.4 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.24 EMC78606.1 - 0.0081 16.0 0.1 0.013 15.3 0.1 1.2 1 0 0 1 1 1 1 Matrixin ADAM_CR_2 PF17771.1 EMC78606.1 - 0.018 15.5 9.2 0.018 15.5 9.2 6.3 4 2 1 5 5 3 0 ADAM cysteine-rich domain Peptidase_M43 PF05572.13 EMC78606.1 - 0.054 13.4 0.0 0.16 11.9 0.0 1.8 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A Peptidase_M54 PF07998.11 EMC78606.1 - 0.079 12.9 0.3 0.15 12.0 0.3 1.4 1 0 0 1 1 1 0 Peptidase family M54 Peptidase_M66 PF10462.9 EMC78606.1 - 0.13 11.2 0.1 0.2 10.6 0.1 1.2 1 0 0 1 1 1 0 Peptidase M66 Zincin_1 PF06262.11 EMC78606.1 - 0.13 12.4 0.1 0.24 11.5 0.1 1.3 1 0 0 1 1 1 0 Zincin-like metallopeptidase DUF3810 PF12725.7 EMC78606.1 - 0.14 11.5 0.4 0.2 11.0 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) DUF4953 PF16313.5 EMC78606.1 - 0.21 10.8 0.1 0.28 10.3 0.1 1.1 1 0 0 1 1 1 0 Met-zincin Collagen PF01391.18 EMC78608.1 - 5.5e-09 35.7 1.5 4.5e-07 29.5 1.5 2.1 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) Filament PF00038.21 EMC78609.1 - 1.9e-83 280.6 37.5 2.9e-64 217.6 21.4 3.2 2 2 1 3 3 3 2 Intermediate filament protein Filament_head PF04732.14 EMC78609.1 - 0.00025 21.8 8.7 0.00073 20.4 0.4 2.5 2 0 0 2 2 2 1 Intermediate filament head (DNA binding) region DUF1664 PF07889.12 EMC78609.1 - 0.017 15.2 1.7 0.017 15.2 1.7 3.9 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) JIP_LZII PF16471.5 EMC78609.1 - 1.9 8.7 27.9 2.1 8.6 0.8 6.0 3 3 3 6 6 6 0 JNK-interacting protein leucine zipper II Lectin_N PF03954.14 EMC78609.1 - 6 6.6 17.3 8.2 6.2 1.3 3.5 1 1 2 3 3 3 0 Hepatic lectin, N-terminal domain Baculo_PEP_C PF04513.12 EMC78609.1 - 8.6 6.4 13.9 10 6.2 4.1 3.7 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DOCK_N PF16172.5 EMC78610.1 - 2e-108 362.7 0.4 6.1e-108 361.1 0.1 1.9 2 0 0 2 2 2 1 DOCK N-terminus DHR-2 PF06920.13 EMC78610.1 - 1.8e-87 294.2 8.3 6e-87 292.5 8.3 1.9 1 1 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 EMC78610.1 - 2.6e-59 200.3 0.3 9.3e-59 198.5 0.3 2.0 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins SH3_9 PF14604.6 EMC78610.1 - 6.2e-09 35.6 0.0 1.4e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC78610.1 - 6.4e-09 35.3 0.0 1.5e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC78610.1 - 4.5e-06 26.2 0.0 9.6e-06 25.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF1160 PF06648.11 EMC78610.1 - 0.0083 16.1 0.0 0.037 14.0 0.0 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1160) PI3K_C2 PF00792.24 EMC78610.1 - 0.078 12.9 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 Phosphoinositide 3-kinase C2 Vps39_1 PF10366.9 EMC78610.1 - 0.46 10.8 3.0 1.6 9.1 0.2 3.2 2 1 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 GnRH PF00446.17 EMC78611.1 - 0.0016 18.6 5.2 0.0016 18.6 5.2 1.6 2 0 0 2 2 2 1 Gonadotropin-releasing hormone Pentapeptide PF00805.22 EMC78612.1 - 1.4e-37 126.9 23.6 1.4e-12 47.0 1.9 4.6 2 2 1 4 4 4 4 Pentapeptide repeats (8 copies) BTB_2 PF02214.22 EMC78612.1 - 1.2e-20 73.7 0.0 2e-20 72.9 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Pentapeptide_4 PF13599.6 EMC78612.1 - 4.2e-20 71.7 0.3 5e-07 29.8 0.0 3.2 1 1 2 3 3 3 3 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 EMC78612.1 - 3.6e-14 52.7 0.0 9.3e-06 25.7 0.0 4.4 1 1 0 3 3 3 3 Pentapeptide repeats (9 copies) KHA PF11834.8 EMC78612.1 - 4.7e-09 36.2 0.0 8.7e-09 35.3 0.0 1.4 1 0 0 1 1 1 1 KHA, dimerisation domain of potassium ion channel BTB PF00651.31 EMC78612.1 - 2.5e-05 24.5 0.0 7.9e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain BTB_3 PF16017.5 EMC78612.1 - 3e-05 24.1 0.0 5.7e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain PP1_bind PF15276.6 EMC78613.1 - 5.4e-19 68.3 0.1 7.1e-19 67.9 0.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 1 binding COE1_DBD PF16422.5 EMC78614.1 - 2.5e-142 472.2 3.6 3.2e-142 471.8 3.6 1.1 1 0 0 1 1 1 1 Transcription factor COE1 DNA-binding domain COE1_HLH PF16423.5 EMC78614.1 - 1.3e-34 117.6 2.0 7.5e-28 96.0 0.3 2.5 2 0 0 2 2 2 2 Transcription factor COE1 helix-loop-helix domain TIG PF01833.24 EMC78614.1 - 2.3e-12 46.8 0.1 7.4e-12 45.2 0.1 1.9 1 0 0 1 1 1 1 IPT/TIG domain Pericardin_rpt PF07054.11 EMC78614.1 - 0.087 13.0 0.1 0.34 11.1 0.1 2.0 1 0 0 1 1 1 0 Pericardin like repeat WD40 PF00400.32 EMC78615.1 - 7e-10 39.4 4.2 3 8.8 0.1 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC78615.1 - 1.3e-05 25.4 0.2 0.76 10.1 0.0 4.4 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Y_phosphatase2 PF03162.13 EMC78615.1 - 0.049 13.2 0.5 1.3 8.6 0.1 2.5 2 0 0 2 2 2 0 Tyrosine phosphatase family BNIP3 PF06553.12 EMC78616.1 - 2.1e-84 282.1 3.0 2.3e-84 281.9 3.0 1.0 1 0 0 1 1 1 1 BNIP3 DUF3319 PF11782.8 EMC78616.1 - 0.013 15.5 0.1 0.022 14.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3319) Amidohydro_1 PF01979.20 EMC78617.1 - 1.7e-50 172.3 0.1 2.2e-50 171.9 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EMC78617.1 - 1.8e-12 47.5 0.5 1.6e-07 31.2 0.0 2.6 3 0 0 3 3 3 2 Amidohydrolase family 7tm_1 PF00001.21 EMC78618.1 - 4.8e-80 268.7 5.3 7.5e-80 268.0 5.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC78618.1 - 2.5e-18 66.4 3.9 3.6e-18 65.9 3.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC78618.1 - 2e-10 40.8 5.0 3.5e-10 40.0 5.0 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 EMC78618.1 - 5.4e-07 29.3 0.2 8.8e-07 28.6 0.2 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 EMC78618.1 - 0.00044 20.1 5.9 0.0053 16.5 4.0 2.7 3 0 0 3 3 3 1 Olfactory receptor RVT_1 PF00078.27 EMC78619.1 - 0.023 14.2 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) LRR_8 PF13855.6 EMC78620.1 - 3e-80 263.9 69.3 2.2e-16 59.4 2.3 5.6 1 1 5 7 7 7 7 Leucine rich repeat LRR_5 PF13306.6 EMC78620.1 - 3.2e-20 72.4 0.8 1.2e-09 38.2 0.0 2.6 1 1 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 EMC78620.1 - 1.5e-19 69.7 39.3 5.9e-06 26.5 5.2 6.6 2 2 6 8 8 8 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC78620.1 - 1.3e-12 47.5 7.8 2.5e-05 23.9 0.3 3.7 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 EMC78620.1 - 3.1e-11 42.2 34.4 0.63 10.8 0.4 10.5 10 1 0 10 10 10 4 Leucine Rich Repeat LRR_6 PF13516.6 EMC78620.1 - 0.00062 19.6 33.5 2.3 8.5 0.7 8.6 9 0 0 9 9 9 4 Leucine Rich repeat LRRNT PF01462.18 EMC78620.1 - 0.024 14.3 3.7 0.04 13.6 1.9 2.3 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain LSR PF05624.14 EMC78620.1 - 9.5 6.3 6.5 0.75 9.8 1.2 1.9 2 0 0 2 2 2 0 Lipolysis stimulated receptor (LSR) EGF_2 PF07974.13 EMC78621.1 - 0.0071 16.7 3.9 0.017 15.5 3.9 1.7 1 1 0 1 1 1 1 EGF-like domain EGF PF00008.27 EMC78621.1 - 0.0072 16.6 4.6 0.013 15.8 4.6 1.4 1 0 0 1 1 1 1 EGF-like domain DUF3844 PF12955.7 EMC78621.1 - 0.032 14.3 1.2 0.038 14.1 1.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3844) Laminin_EGF PF00053.24 EMC78621.1 - 0.07 13.3 4.2 0.096 12.8 4.2 1.3 1 0 0 1 1 1 0 Laminin EGF domain hEGF PF12661.7 EMC78621.1 - 0.13 12.9 1.8 0.13 12.9 1.8 2.1 3 0 0 3 3 3 0 Human growth factor-like EGF DUF842 PF05811.13 EMC78622.1 - 8.8e-35 119.3 9.2 9.8e-35 119.1 9.2 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) Vicilin_N PF04702.12 EMC78622.1 - 0.12 12.2 7.8 0.14 11.9 7.8 1.2 1 1 0 1 1 1 0 Vicilin N terminal region LSM PF01423.22 EMC78623.1 - 1.6e-19 69.3 0.2 1.8e-19 69.2 0.2 1.0 1 0 0 1 1 1 1 LSM domain Prenylcys_lyase PF07156.14 EMC78624.1 - 5e-124 414.1 0.0 6e-124 413.8 0.0 1.0 1 0 0 1 1 1 1 Prenylcysteine lyase RRM_1 PF00076.22 EMC78625.1 - 4.1e-66 218.7 0.0 2e-23 82.0 0.0 3.1 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMC78625.1 - 3.9e-11 42.7 0.0 1.3e-05 25.0 0.0 3.0 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_7 PF16367.5 EMC78625.1 - 1.7e-07 31.2 0.2 0.33 11.1 0.0 4.3 3 1 0 3 3 3 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EMC78625.1 - 0.00011 22.2 0.9 0.1 12.6 0.0 3.7 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif Calcipressin PF04847.12 EMC78625.1 - 0.00013 21.7 0.0 0.05 13.3 0.0 2.6 3 0 0 3 3 3 1 Calcipressin PHM7_cyt PF14703.6 EMC78625.1 - 0.00015 22.1 0.1 4.6 7.4 0.0 3.3 2 1 1 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter RRM_3 PF08777.11 EMC78625.1 - 0.00039 20.4 0.0 0.82 9.7 0.0 3.1 2 1 1 3 3 3 1 RNA binding motif Nup35_RRM PF05172.13 EMC78625.1 - 0.0031 17.4 0.3 0.18 11.8 0.2 3.1 2 1 0 2 2 2 1 Nup53/35/40-type RNA recognition motif DbpA PF03880.15 EMC78625.1 - 0.0044 17.0 0.0 0.93 9.5 0.0 3.1 3 0 0 3 3 3 1 DbpA RNA binding domain XOO_2897-deam PF14440.6 EMC78625.1 - 0.081 13.0 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase Cas_Cas2CT1978 PF09707.10 EMC78625.1 - 0.13 12.3 0.0 12 6.1 0.0 2.8 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Cas2CT1978) Arm PF00514.23 EMC78628.1 - 5e-35 118.5 19.9 1.9e-07 30.9 0.0 8.9 8 1 1 9 9 9 5 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EMC78628.1 - 2.9e-14 53.2 4.3 0.0063 16.9 0.3 5.6 2 2 2 5 5 5 4 HEAT repeats HEAT PF02985.22 EMC78628.1 - 3.8e-14 51.6 10.9 0.074 13.3 0.0 7.7 8 1 1 9 9 8 4 HEAT repeat HEAT_EZ PF13513.6 EMC78628.1 - 1.6e-11 44.4 14.0 0.0022 18.5 0.0 6.1 6 1 1 7 7 6 4 HEAT-like repeat Cnd1 PF12717.7 EMC78628.1 - 6e-11 42.6 0.9 0.25 11.4 0.2 5.3 1 1 5 6 6 6 4 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EMC78628.1 - 3.3e-08 32.6 4.1 0.0094 14.6 0.5 3.8 2 2 1 4 4 4 3 Adaptin N terminal region CHASE6_C PF17150.4 EMC78628.1 - 2.8e-05 24.7 1.3 4.6 8.0 0.0 5.9 5 1 1 6 6 6 1 C-terminal domain of two-partite extracellular sensor domain DNA_alkylation PF08713.11 EMC78628.1 - 9.5e-05 22.2 0.0 1.7 8.3 0.0 3.4 2 1 0 3 3 3 2 DNA alkylation repair enzyme RICTOR_V PF14668.6 EMC78628.1 - 0.00057 20.1 0.1 2 8.7 0.0 3.9 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 Proteasom_PSMB PF10508.9 EMC78628.1 - 0.0013 17.4 2.4 0.011 14.3 0.3 2.5 1 1 1 2 2 2 1 Proteasome non-ATPase 26S subunit CLASP_N PF12348.8 EMC78628.1 - 0.0025 17.4 0.1 22 4.5 0.0 3.6 1 1 0 3 3 3 0 CLASP N terminal RTP1_C1 PF10363.9 EMC78628.1 - 0.0029 17.8 0.6 0.094 12.9 0.2 3.3 4 2 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_PBS PF03130.16 EMC78628.1 - 0.0034 17.9 6.0 0.26 12.1 0.2 4.6 5 0 0 5 5 3 1 PBS lyase HEAT-like repeat V-ATPase_H_C PF11698.8 EMC78628.1 - 0.0039 17.3 0.6 1.4 9.1 0.1 3.5 3 1 0 4 4 4 1 V-ATPase subunit H DUF3361 PF11841.8 EMC78628.1 - 0.025 14.5 1.1 3 7.8 0.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3361) DUF3731 PF12531.8 EMC78628.1 - 0.059 13.2 0.3 3.5 7.4 0.1 2.5 2 0 0 2 2 2 0 DNA-K related protein API5 PF05918.11 EMC78628.1 - 0.25 10.1 0.8 6.7 5.4 0.4 2.8 2 2 2 4 4 4 0 Apoptosis inhibitory protein 5 (API5) TPR_16 PF13432.6 EMC78628.1 - 6.1 7.6 5.8 26 5.5 0.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat PIP5K PF01504.18 EMC78629.1 - 3.1e-77 259.5 0.2 4e-77 259.1 0.2 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Arm PF00514.23 EMC78630.1 - 4.6e-50 166.2 24.1 1.2e-07 31.5 0.1 11.7 11 0 0 11 11 11 8 Armadillo/beta-catenin-like repeat EDR1 PF14381.6 EMC78630.1 - 4.3e-39 134.3 0.0 2.3e-38 132.0 0.0 2.4 1 1 0 1 1 1 1 Ethylene-responsive protein kinase Le-CTR1 HEAT_2 PF13646.6 EMC78630.1 - 6.4e-27 93.8 14.5 2.4e-05 24.6 0.0 7.0 1 1 5 8 8 8 8 HEAT repeats HEAT PF02985.22 EMC78630.1 - 7.6e-23 78.6 16.3 0.0059 16.8 0.1 9.9 10 0 0 10 10 10 6 HEAT repeat HEAT_EZ PF13513.6 EMC78630.1 - 5.7e-16 58.6 11.3 0.00051 20.5 0.0 8.7 9 1 0 9 9 9 3 HEAT-like repeat Adaptin_N PF01602.20 EMC78630.1 - 2.2e-12 46.4 9.3 3.8e-08 32.3 4.9 3.1 2 1 0 2 2 2 2 Adaptin N terminal region V-ATPase_H_C PF11698.8 EMC78630.1 - 1.9e-11 44.1 5.7 0.3 11.2 0.0 6.2 2 2 4 6 6 6 4 V-ATPase subunit H Cnd1 PF12717.7 EMC78630.1 - 6.6e-11 42.5 7.7 0.12 12.4 0.0 5.1 3 2 2 6 6 6 4 non-SMC mitotic condensation complex subunit 1 Arm_2 PF04826.13 EMC78630.1 - 1e-05 25.1 12.4 0.13 11.7 0.7 5.8 1 1 3 4 4 4 4 Armadillo-like V-ATPase_H_N PF03224.14 EMC78630.1 - 3.1e-05 23.4 4.9 0.023 14.0 0.0 4.0 2 1 1 3 3 3 2 V-ATPase subunit H Atx10homo_assoc PF09759.9 EMC78630.1 - 0.025 14.6 0.6 5.3 7.1 0.0 3.7 2 1 2 5 5 5 0 Spinocerebellar ataxia type 10 protein domain UNC45-central PF11701.8 EMC78630.1 - 0.59 10.1 9.5 0.22 11.5 0.5 4.0 2 2 2 5 5 5 0 Myosin-binding striated muscle assembly central OTU PF02338.19 EMC78631.1 - 8.9e-25 87.6 0.0 1.9e-24 86.5 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EMC78631.1 - 0.0071 15.8 0.0 0.6 9.5 0.3 2.2 1 1 0 2 2 2 2 Peptidase C65 Otubain RhoGAP PF00620.27 EMC78633.1 - 1.6e-50 170.9 0.1 3e-50 170.0 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain PDZ_6 PF17820.1 EMC78633.1 - 2.8e-15 55.9 0.2 1.5e-14 53.6 0.0 2.3 2 0 0 2 2 2 1 PDZ domain PH_9 PF15410.6 EMC78633.1 - 2.6e-14 53.6 0.0 8.2e-14 52.0 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EMC78633.1 - 3.3e-13 50.0 2.8 1.6e-12 47.9 0.2 2.8 2 0 0 2 2 2 1 PH domain PDZ PF00595.24 EMC78633.1 - 8e-10 38.9 0.0 2.8e-09 37.2 0.0 2.0 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC78633.1 - 4.6e-06 26.9 0.1 2e-05 24.8 0.0 2.1 2 0 0 2 2 2 1 PDZ domain PH_11 PF15413.6 EMC78633.1 - 0.0008 19.8 0.0 0.0058 17.0 0.0 2.6 1 0 0 1 1 1 1 Pleckstrin homology domain Pribosyltran PF00156.27 EMC78634.1 - 8e-15 54.7 0.0 1.5e-06 27.8 0.0 2.0 2 0 0 2 2 2 2 Phosphoribosyl transferase domain Enkurin PF13864.6 EMC78635.1 - 1.6e-26 92.6 9.2 1.6e-26 92.6 9.2 2.6 3 1 0 3 3 3 1 Calmodulin-binding XkdW PF09636.10 EMC78635.1 - 0.22 11.6 4.2 0.1 12.7 0.8 2.1 2 1 0 2 2 2 0 XkdW protein MOSC_N PF03476.16 EMC78636.1 - 7.8e-30 103.2 0.0 1.4e-29 102.4 0.0 1.4 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain MOSC PF03473.17 EMC78636.1 - 1.2e-24 86.8 0.0 3e-24 85.5 0.0 1.6 1 0 0 1 1 1 1 MOSC domain Aminotran_5 PF00266.19 EMC78636.1 - 4e-22 78.7 0.0 1.7e-21 76.6 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class-V FERM_N PF09379.10 EMC78637.1 - 2.2e-16 59.5 0.0 3.4e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 FERM N-terminal domain FERM_M PF00373.18 EMC78637.1 - 3.1e-13 50.1 0.1 5.1e-13 49.5 0.1 1.3 1 0 0 1 1 1 1 FERM central domain Trm112p PF03966.16 EMC78637.1 - 0.0074 16.8 0.0 4.8 7.8 0.0 2.8 2 1 1 3 3 3 2 Trm112p-like protein Y_phosphatase PF00102.27 EMC78638.1 - 9.5e-81 270.8 1.5 1.1e-80 270.6 1.5 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EMC78638.1 - 8.8e-06 25.6 0.1 1.5e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC78638.1 - 5.2e-05 23.3 0.0 8.4e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EMC78638.1 - 6.2e-05 23.2 0.1 0.0001 22.5 0.1 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 EMC78638.1 - 0.13 11.8 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Myotub-related PF06602.14 EMC78638.1 - 0.14 11.0 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain FERM_C PF09380.10 EMC78640.1 - 3.2e-22 78.7 0.0 7.5e-22 77.5 0.0 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 EMC78640.1 - 2.7e-17 63.2 0.7 5.4e-17 62.3 0.2 1.8 2 0 0 2 2 2 1 FERM central domain FA PF08736.11 EMC78640.1 - 1.7e-12 47.2 10.7 1.7e-12 47.2 10.7 2.1 2 0 0 2 2 2 1 FERM adjacent (FA) FERM_N PF09379.10 EMC78640.1 - 2.1e-12 46.8 0.2 6.3e-12 45.3 0.2 1.8 1 0 0 1 1 1 1 FERM N-terminal domain DOMON PF03351.17 EMC78641.1 - 2.6e-23 82.6 0.0 3.2e-23 82.3 0.0 1.1 1 0 0 1 1 1 1 DOMON domain DUF5134 PF17197.4 EMC78642.1 - 0.093 12.6 2.1 0.1 12.5 0.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5134) Tubulin_2 PF13809.6 EMC78642.1 - 0.12 11.5 0.4 0.26 10.4 0.0 1.6 2 0 0 2 2 2 0 Tubulin like Neur_chan_memb PF02932.16 EMC78642.1 - 0.16 12.0 2.7 0.51 10.4 0.1 2.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DAG1 PF05454.11 EMC78642.1 - 0.24 10.8 0.1 0.46 9.8 0.1 1.5 1 1 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) Sarcoglycan_1 PF04790.13 EMC78642.1 - 0.9 8.8 8.3 0.88 8.9 0.9 2.5 2 0 0 2 2 2 0 Sarcoglycan complex subunit protein SR-25 PF10500.9 EMC78642.1 - 1.9 8.1 13.4 2.9 7.5 13.4 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4698 PF15769.5 EMC78643.1 - 1.3e-155 519.3 14.0 1.4e-155 519.1 14.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4698) Ribosomal_S19e PF01090.19 EMC78643.1 - 0.068 12.9 0.5 1.9 8.2 0.0 2.9 3 0 0 3 3 3 0 Ribosomal protein S19e HET PF06985.11 EMC78643.1 - 0.17 12.3 3.4 0.12 12.7 0.7 2.1 2 0 0 2 2 2 0 Heterokaryon incompatibility protein (HET) AMPK1_CBM PF16561.5 EMC78644.1 - 2.6e-35 120.5 0.3 4.7e-35 119.7 0.3 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 EMC78644.1 - 8.5e-28 96.4 1.8 1.5e-27 95.7 1.8 1.4 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain CBM_48 PF02922.18 EMC78644.1 - 0.008 16.5 0.0 0.016 15.5 0.0 1.5 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) CNH PF00780.22 EMC78645.1 - 3.6e-60 203.9 0.0 8e-60 202.8 0.0 1.5 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.25 EMC78645.1 - 2.3e-59 200.9 2.1 3.8e-58 196.9 0.0 3.3 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC78645.1 - 3.3e-28 98.7 0.0 9.1e-28 97.2 0.0 1.8 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 EMC78645.1 - 6.3e-10 39.5 0.0 2.4e-09 37.6 0.0 2.1 2 0 0 2 2 2 1 PH domain C1_1 PF00130.22 EMC78645.1 - 2.5e-05 24.1 9.2 5.5e-05 23.0 9.2 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Seadorna_VP7 PF07387.11 EMC78645.1 - 0.00053 19.1 0.0 0.0018 17.4 0.0 1.9 1 0 0 1 1 1 1 Seadornavirus VP7 Pkinase_C PF00433.24 EMC78645.1 - 0.0037 17.9 1.3 0.011 16.4 1.3 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.23 EMC78645.1 - 0.047 13.6 0.1 0.047 13.6 0.1 5.1 6 2 1 7 7 7 0 Phosphotransferase enzyme family ATG16 PF08614.11 EMC78646.1 - 0.0049 17.1 27.5 0.0049 17.1 27.5 4.0 1 1 2 3 3 3 1 Autophagy protein 16 (ATG16) GP57 PF17594.2 EMC78646.1 - 0.19 11.5 5.8 0.12 12.1 0.4 3.2 4 0 0 4 4 4 0 Phage Tail fiber assembly helper gene product 57 CENP-F_leu_zip PF10473.9 EMC78646.1 - 0.95 9.5 74.7 3.3 7.7 19.7 5.3 1 1 4 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SEA PF01390.20 EMC78646.1 - 2.9 8.0 6.1 5.6 7.1 0.3 2.8 2 0 0 2 2 2 0 SEA domain Ras PF00071.22 EMC78647.1 - 4.5e-55 185.7 0.5 6.1e-55 185.2 0.5 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC78647.1 - 2.5e-31 108.4 1.9 2.8e-31 108.2 0.2 1.9 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC78647.1 - 9.4e-16 57.8 0.2 1.3e-15 57.3 0.2 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC78647.1 - 1.2e-06 28.3 0.4 2e-06 27.5 0.3 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EMC78647.1 - 0.0011 19.0 0.3 0.0019 18.2 0.3 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dioxygenase_N PF04444.14 EMC78647.1 - 0.091 12.6 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Catechol dioxygenase N terminus Glycoprot_B_PH2 PF17417.2 EMC78647.1 - 0.43 10.9 3.9 2 8.8 0.9 2.3 2 1 0 2 2 2 0 Herpesvirus Glycoprotein B PH-like domain HTH_3 PF01381.22 EMC78651.1 - 9e-13 48.1 0.2 1.3e-12 47.6 0.2 1.2 1 0 0 1 1 1 1 Helix-turn-helix MBF1 PF08523.10 EMC78651.1 - 1.2e-06 28.8 1.8 1.4e-06 28.7 0.3 1.8 2 1 0 2 2 2 1 Multiprotein bridging factor 1 HTH_31 PF13560.6 EMC78651.1 - 0.00015 22.0 0.0 0.00021 21.6 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 EMC78651.1 - 0.022 14.8 0.2 0.031 14.3 0.2 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_38 PF13936.6 EMC78651.1 - 0.046 13.5 0.0 0.087 12.6 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Ocnus PF05005.15 EMC78652.1 - 1.9e-21 76.2 0.1 2e-21 76.1 0.1 1.0 1 0 0 1 1 1 1 Janus/Ocnus family (Ocnus) Ras PF00071.22 EMC78653.1 - 8.1e-12 45.0 0.1 1.1e-05 25.1 0.3 2.3 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EMC78653.1 - 4.1e-07 30.2 1.0 4.1e-07 30.2 1.0 2.7 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC78653.1 - 6.6e-06 25.7 0.1 2.2e-05 24.0 0.1 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC78653.1 - 0.00014 21.9 0.0 0.00044 20.3 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 EMC78653.1 - 0.065 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Kunitz_BPTI PF00014.23 EMC78654.1 - 6.5e-35 119.2 19.1 2.6e-17 62.8 6.6 2.5 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Lipocalin PF00061.23 EMC78654.1 - 2.1e-26 92.8 0.0 2.9e-26 92.4 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family SL4P PF17618.2 EMC78654.1 - 0.041 13.9 0.0 0.076 13.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized Strongylid L4 protein NPP PF08384.10 EMC78654.1 - 0.07 13.2 1.7 0.15 12.1 1.7 1.6 1 0 0 1 1 1 0 Pro-opiomelanocortin, N-terminal region Megourin PF17560.2 EMC78654.1 - 1.1 9.5 9.8 0.82 10.0 2.6 2.4 2 0 0 2 2 2 0 Aphid Megourins Mut7-C PF01927.16 EMC78655.1 - 4.9e-07 29.9 0.0 5.9e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Mut7-C RNAse domain SCNM1_acidic PF15805.5 EMC78659.1 - 2.2e-24 84.9 0.3 3.7e-24 84.2 0.3 1.4 1 0 0 1 1 1 1 Acidic C-terminal region of sodium channel modifier 1 SCNM1 zf-SCNM1 PF15803.5 EMC78659.1 - 1.5e-15 56.5 1.8 2.6e-15 55.8 1.8 1.4 1 0 0 1 1 1 1 Zinc-finger of sodium channel modifier 1 Tropomodulin PF03250.14 EMC78660.1 - 1.9e-15 57.2 0.0 3.7e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 Tropomodulin LRR_6 PF13516.6 EMC78660.1 - 0.1 12.7 0.1 0.1 12.7 0.1 3.3 3 0 0 3 3 3 0 Leucine Rich repeat Ole-e-6 PF09253.10 EMC78660.1 - 0.16 11.9 0.0 0.35 10.9 0.0 1.5 1 0 0 1 1 1 0 Pollen allergen ole e 6 Tropomodulin PF03250.14 EMC78661.1 - 2.2e-10 40.8 3.0 2.4e-10 40.6 3.0 1.0 1 0 0 1 1 1 1 Tropomodulin Ribosomal_S13 PF00416.22 EMC78661.1 - 0.17 12.3 0.1 0.17 12.3 0.1 1.1 1 0 0 1 1 1 0 Ribosomal protein S13/S18 DUF3007 PF11460.8 EMC78661.1 - 0.17 12.2 2.3 0.2 11.9 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3007) PIP5K PF01504.18 EMC78662.1 - 1.7e-91 306.3 0.0 2.2e-91 305.9 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase UIM PF02809.20 EMC78663.1 - 2.6e-08 33.2 5.7 0.00011 21.9 0.4 3.0 2 0 0 2 2 2 2 Ubiquitin interaction motif VWA_2 PF13519.6 EMC78663.1 - 7.5e-06 26.6 1.7 3.8e-05 24.3 0.0 2.9 4 1 0 4 4 4 1 von Willebrand factor type A domain RAP80_UIM PF18282.1 EMC78663.1 - 0.024 14.4 3.0 0.024 14.4 3.0 2.6 2 0 0 2 2 2 0 RAP80 N-terminal ubiquitin interaction motif DAGK_cat PF00781.24 EMC78663.1 - 0.03 14.0 0.1 0.49 10.0 0.0 2.3 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain K_channel_TID PF07941.11 EMC78663.1 - 0.051 14.0 6.5 0.14 12.7 6.5 1.7 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain RFX_DNA_binding PF02257.15 EMC78664.1 - 8.3e-23 80.8 0.2 2e-22 79.6 0.2 1.6 1 1 0 1 1 1 1 RFX DNA-binding domain RFX5_N PF18326.1 EMC78664.1 - 1.4e-14 53.6 2.3 2e-14 53.1 2.3 1.3 1 0 0 1 1 1 1 RFX5 N-terminal domain GATA-N PF05349.12 EMC78665.1 - 2.9 8.2 7.5 1 9.6 1.9 1.9 1 1 1 2 2 2 0 GATA-type transcription activator, N-terminal SBP56 PF05694.11 EMC78666.1 - 4.7e-182 605.9 0.0 5.2e-182 605.7 0.0 1.0 1 0 0 1 1 1 1 56kDa selenium binding protein (SBP56) Lactonase PF10282.9 EMC78666.1 - 0.0073 15.6 0.0 0.021 14.1 0.0 1.7 2 0 0 2 2 2 1 Lactonase, 7-bladed beta-propeller SBP56 PF05694.11 EMC78667.1 - 1.6e-144 482.1 0.0 1.8e-144 481.9 0.0 1.0 1 0 0 1 1 1 1 56kDa selenium binding protein (SBP56) Lactonase PF10282.9 EMC78667.1 - 0.0022 17.3 0.0 0.0054 16.0 0.0 1.6 2 0 0 2 2 2 1 Lactonase, 7-bladed beta-propeller SH3_6 PF12913.7 EMC78667.1 - 0.082 12.5 0.2 0.4 10.3 0.0 2.1 2 0 0 2 2 2 0 SH3 domain (SH3b1 type) SGL PF08450.12 EMC78667.1 - 0.13 11.8 0.0 0.8 9.2 0.0 2.0 1 1 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region SBP56 PF05694.11 EMC78668.1 - 4e-220 731.3 0.0 4.6e-220 731.1 0.0 1.0 1 0 0 1 1 1 1 56kDa selenium binding protein (SBP56) Lactonase PF10282.9 EMC78668.1 - 0.00047 19.5 0.0 0.0032 16.8 0.0 2.0 2 0 0 2 2 2 1 Lactonase, 7-bladed beta-propeller zf-C2H2_4 PF13894.6 EMC78669.1 - 4e-12 45.9 44.2 0.023 15.5 0.6 6.7 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC78669.1 - 0.00021 21.5 48.9 0.12 12.9 0.3 6.8 6 1 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EMC78669.1 - 0.001 19.3 23.1 0.15 12.4 0.5 5.4 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 EMC78669.1 - 0.012 15.9 36.3 0.11 12.8 0.5 4.6 4 0 0 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding FYVE PF01363.21 EMC78669.1 - 0.057 13.6 20.6 0.2 11.8 0.1 5.2 5 1 1 6 6 6 0 FYVE zinc finger zinc_ribbon_4 PF13717.6 EMC78669.1 - 0.34 10.9 15.1 1.2 9.2 0.1 5.2 5 0 0 5 5 5 0 zinc-ribbon domain Zn-C2H2_12 PF18112.1 EMC78669.1 - 0.63 10.6 11.4 2.4 8.7 0.7 4.0 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain Rubredoxin PF00301.20 EMC78669.1 - 0.75 9.9 0.0 0.75 9.9 0.0 5.1 6 0 0 6 6 6 0 Rubredoxin FOXP-CC PF16159.5 EMC78669.1 - 1.2 9.8 18.3 8.2 7.1 0.1 4.5 2 1 2 4 4 4 0 FOXP coiled-coil domain DUF2757 PF10955.8 EMC78669.1 - 5.3 7.4 13.6 1.9 8.8 4.3 4.0 3 1 0 3 3 3 0 Protein of unknown function (DUF2757) zf-C2H2_2 PF12756.7 EMC78669.1 - 5.6 7.4 34.5 6 7.3 1.7 5.4 3 2 1 4 4 4 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_5 PF13719.6 EMC78669.1 - 9.2 6.1 10.5 4.6 7.1 0.2 4.1 4 0 0 4 4 4 0 zinc-ribbon domain PT PF04886.12 EMC78670.1 - 4.2e-09 35.8 179.5 0.2 11.2 11.1 10.9 1 1 7 8 8 8 5 PT repeat KCNQC3-Ank-G_bd PF11956.8 EMC78670.1 - 2.5 8.4 19.8 8.7 6.7 1.1 4.2 1 1 0 3 3 3 0 Ankyrin-G binding motif of KCNQ2-3 ERbeta_N PF12497.8 EMC78671.1 - 0.0094 15.7 0.8 0.011 15.5 0.8 1.1 1 0 0 1 1 1 1 Estrogen receptor beta Proteasome PF00227.26 EMC78672.1 - 1.8e-21 76.5 0.0 2e-21 76.4 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Retinal PF15449.6 EMC78673.1 - 0 1294.5 46.1 0 1294.3 46.1 1.0 1 0 0 1 1 1 1 Retinal protein CAP_GLY PF01302.25 EMC78674.1 - 1.6e-73 242.7 4.5 5.2e-24 84.0 0.4 3.3 3 0 0 3 3 3 3 CAP-Gly domain Ank_2 PF12796.7 EMC78674.1 - 3.2e-12 46.8 0.5 2.6e-07 31.1 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC78674.1 - 2.6e-07 31.1 0.2 2.6e-05 24.7 0.1 3.1 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 EMC78674.1 - 3.7e-05 24.0 4.4 0.015 15.7 0.2 3.8 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 EMC78674.1 - 0.00014 22.0 2.3 1.1 10.0 0.1 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EMC78674.1 - 0.00038 20.7 1.7 0.13 12.7 0.1 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Tubulin-binding PF00418.19 EMC78674.1 - 0.027 14.5 0.2 0.076 13.1 0.2 1.8 1 0 0 1 1 1 0 Tau and MAP protein, tubulin-binding repeat RRM_1 PF00076.22 EMC78677.1 - 2.7e-44 148.9 0.7 2.6e-15 56.0 0.4 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) hnRNP_Q_AcD PF18360.1 EMC78677.1 - 1.4e-31 108.2 0.1 2.9e-31 107.2 0.1 1.5 1 0 0 1 1 1 1 Heterogeneous nuclear ribonucleoprotein Q acidic domain RRM_7 PF16367.5 EMC78677.1 - 2.9e-09 36.9 0.1 0.01 15.9 0.0 4.1 2 2 2 4 4 4 2 RNA recognition motif RRM_5 PF13893.6 EMC78677.1 - 3.5e-06 26.6 0.0 4.3e-05 23.1 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMC78677.1 - 0.0015 18.4 0.0 0.01 15.6 0.0 2.4 3 0 0 3 3 3 1 Occluded RNA-recognition motif Limkain-b1 PF11608.8 EMC78677.1 - 0.0023 18.0 0.1 2.7 8.1 0.1 3.7 3 1 0 3 3 3 1 Limkain b1 Nup35_RRM_2 PF14605.6 EMC78677.1 - 0.0024 17.8 0.1 12 5.9 0.0 3.4 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif Calcipressin PF04847.12 EMC78677.1 - 0.085 12.6 0.1 0.44 10.3 0.1 2.2 3 0 0 3 3 3 0 Calcipressin PHM7_cyt PF14703.6 EMC78677.1 - 0.088 13.0 0.7 43 4.3 0.0 4.1 3 2 2 5 5 5 0 Cytosolic domain of 10TM putative phosphate transporter Cep57_MT_bd PF06657.13 EMC78678.1 - 0.0016 18.9 4.3 0.0021 18.4 4.3 1.3 1 0 0 1 1 1 1 Centrosome microtubule-binding domain of Cep57 DivIC PF04977.15 EMC78678.1 - 0.0064 16.2 3.8 0.0075 16.0 3.3 1.4 1 1 0 1 1 1 1 Septum formation initiator HrpB7 PF09486.10 EMC78678.1 - 0.012 16.0 1.1 0.013 15.9 1.1 1.1 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) IATP PF04568.12 EMC78678.1 - 0.012 16.0 17.1 0.043 14.2 17.1 1.9 1 1 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP Prefoldin_2 PF01920.20 EMC78678.1 - 0.014 15.3 4.0 0.015 15.2 4.0 1.1 1 0 0 1 1 1 0 Prefoldin subunit Seryl_tRNA_N PF02403.22 EMC78678.1 - 0.035 14.3 3.0 0.039 14.2 3.0 1.0 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Fib_alpha PF08702.10 EMC78678.1 - 0.047 13.9 2.4 0.05 13.8 2.4 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1192 PF06698.11 EMC78678.1 - 0.06 13.4 4.1 0.11 12.6 4.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1192) Phage_lysis PF03245.13 EMC78678.1 - 0.061 13.5 2.9 0.081 13.1 2.4 1.5 1 1 0 1 1 1 0 Bacteriophage Rz lysis protein THOC7 PF05615.13 EMC78678.1 - 0.07 13.4 5.9 0.082 13.2 5.9 1.1 1 0 0 1 1 1 0 Tho complex subunit 7 Val_tRNA-synt_C PF10458.9 EMC78678.1 - 0.083 13.2 2.4 0.083 13.2 2.4 1.9 1 1 1 2 2 2 0 Valyl tRNA synthetase tRNA binding arm CCDC73 PF15818.5 EMC78678.1 - 0.17 9.7 7.8 0.18 9.7 7.8 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 73 family FlaC_arch PF05377.11 EMC78678.1 - 0.23 11.9 2.0 0.29 11.6 2.0 1.3 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) TMPIT PF07851.13 EMC78678.1 - 0.23 10.7 3.0 0.25 10.6 3.0 1.0 1 0 0 1 1 1 0 TMPIT-like protein Csm1_N PF18504.1 EMC78678.1 - 0.33 11.3 5.1 0.21 11.9 3.3 1.6 1 1 1 2 2 2 0 Csm1 N-terminal domain ABC_tran_Xtn PF12848.7 EMC78678.1 - 0.4 10.7 8.5 0.51 10.4 8.5 1.1 1 0 0 1 1 1 0 ABC transporter XhlA PF10779.9 EMC78678.1 - 0.4 10.9 3.8 0.48 10.7 3.8 1.2 1 0 0 1 1 1 0 Haemolysin XhlA DnaJ PF00226.31 EMC78679.1 - 1.1e-17 63.9 1.4 1.1e-17 63.9 1.4 2.1 2 0 0 2 2 2 1 DnaJ domain DUF1676 PF07898.13 EMC78679.1 - 7.9 6.5 7.5 0.81 9.7 2.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) 7tm_1 PF00001.21 EMC78680.1 - 5.1e-44 150.6 23.9 7.1e-44 150.1 23.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Serpentine_r_xa PF03383.15 EMC78680.1 - 0.028 14.4 0.9 0.028 14.4 0.9 3.2 1 1 1 3 3 3 0 Caenorhabditis serpentine receptor-like protein, class xa HemY_N PF07219.13 EMC78680.1 - 2.9 8.1 7.6 7.5 6.8 0.7 3.3 2 1 1 3 3 3 0 HemY protein N-terminus Orf78 PF06024.12 EMC78680.1 - 3.2 8.1 9.6 0.35 11.2 1.2 3.4 4 0 0 4 4 4 0 Orf78 (ac78) CitMHS PF03600.16 EMC78680.1 - 5 6.2 6.5 13 4.8 6.8 1.5 1 1 0 1 1 1 0 Citrate transporter YTH PF04146.15 EMC78681.1 - 6.1e-42 143.4 0.6 2.6e-41 141.3 0.6 1.9 1 1 0 1 1 1 1 YT521-B-like domain HLH PF00010.26 EMC78682.1 - 5.1e-12 45.6 0.0 7.3e-12 45.1 0.0 1.2 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain ArfGap PF01412.18 EMC78683.1 - 9e-35 119.3 0.2 4.3e-34 117.1 0.0 2.2 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 EMC78683.1 - 1.9e-18 67.1 8.9 3.4e-18 66.2 8.9 1.3 1 0 0 1 1 1 1 BAR domain of APPL family Ank_2 PF12796.7 EMC78683.1 - 1.1e-16 61.2 1.7 2.1e-08 34.6 0.2 2.5 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) PH PF00169.29 EMC78683.1 - 7.9e-11 42.4 0.8 2.1e-10 41.1 0.3 2.0 2 0 0 2 2 2 1 PH domain Ank_5 PF13857.6 EMC78683.1 - 1.1e-08 35.1 0.2 7.3e-08 32.5 0.2 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC78683.1 - 7.8e-08 32.0 0.3 0.001 19.3 0.0 3.9 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 EMC78683.1 - 5e-07 29.9 1.6 2.4e-06 27.7 0.3 2.8 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EMC78683.1 - 1.2e-06 29.0 0.4 6.6e-06 26.6 0.2 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) DUF3287 PF11690.8 EMC78683.1 - 0.013 15.3 0.2 0.038 13.7 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3287) PH_3 PF14593.6 EMC78683.1 - 0.024 14.7 0.0 0.058 13.5 0.0 1.6 1 0 0 1 1 1 0 PH domain PH_2 PF08458.10 EMC78683.1 - 0.04 14.3 0.1 0.14 12.5 0.0 1.9 2 0 0 2 2 1 0 Plant pleckstrin homology-like region PH_13 PF16652.5 EMC78683.1 - 0.052 13.4 1.7 0.063 13.1 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain RCC1 PF00415.18 EMC78684.1 - 3.9e-45 152.2 11.2 1.1e-11 45.1 0.3 4.1 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EMC78684.1 - 6.6e-12 44.9 23.7 0.033 14.0 1.6 5.3 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat Peptidase_C1 PF00112.23 EMC78685.1 - 9.1e-66 222.1 3.6 1.1e-65 221.7 3.6 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EMC78685.1 - 4.7e-09 36.6 0.0 8.4e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EMC78685.1 - 0.001 17.9 0.2 0.07 11.9 0.1 2.3 2 0 0 2 2 2 2 Peptidase C1-like family Pkinase_Tyr PF07714.17 EMC78686.1 - 5.4e-94 314.3 0.0 6.5e-94 314.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC78686.1 - 9.8e-46 156.2 0.0 1.2e-45 155.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 EMC78686.1 - 2.4e-24 85.2 0.0 5.4e-24 84.1 0.0 1.6 1 0 0 1 1 1 1 SH2 domain SH3_9 PF14604.6 EMC78686.1 - 0.00016 21.5 0.4 0.00065 19.5 0.1 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EMC78686.1 - 0.00066 19.3 0.4 0.0022 17.6 0.1 2.1 2 0 0 2 2 2 1 Variant SH3 domain Haspin_kinase PF12330.8 EMC78686.1 - 0.0012 17.8 0.0 0.0022 17.0 0.0 1.3 1 1 0 1 1 1 1 Haspin like kinase domain SH3_1 PF00018.28 EMC78686.1 - 0.0014 18.2 0.4 0.0063 16.1 0.1 2.2 2 0 0 2 2 2 1 SH3 domain APH PF01636.23 EMC78686.1 - 0.04 13.8 0.1 0.46 10.4 0.1 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family zf-RING_14 PF17978.1 EMC78686.1 - 0.16 12.4 0.0 0.57 10.6 0.0 1.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain WASH_WAHD PF11945.8 EMC78689.1 - 0.016 14.7 0.0 0.03 13.9 0.0 1.3 1 0 0 1 1 1 0 WAHD domain of WASH complex 7tm_1 PF00001.21 EMC78690.1 - 2.3e-37 128.7 22.0 2.7e-37 128.5 22.0 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC78690.1 - 0.0021 17.8 18.1 0.2 11.3 18.1 2.8 1 1 0 1 1 1 1 Olfactory receptor Corona_NSP4_C PF16348.5 EMC78690.1 - 0.0088 16.8 0.0 0.017 15.9 0.0 1.5 1 0 0 1 1 1 1 Coronavirus nonstructural protein 4 C-terminus MGC-24 PF05283.11 EMC78691.1 - 5.9e-29 101.3 14.9 1.2e-27 97.0 14.9 2.0 1 1 0 1 1 1 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin PSI PF01437.25 EMC78691.1 - 7 7.3 11.6 20 5.8 11.6 1.8 1 1 0 1 1 1 0 Plexin repeat DUF778 PF05608.12 EMC78692.1 - 7.7e-46 156.9 7.2 4.3e-25 89.2 0.1 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF778) RCDG1 PF15725.5 EMC78693.1 - 0.49 10.8 5.0 0.68 10.4 5.0 1.3 1 0 0 1 1 1 0 Renal cancer differentiation gene 1 protein WD40 PF00400.32 EMC78694.1 - 1.5e-23 82.6 5.4 2.1e-06 28.3 0.1 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat TPR_19 PF14559.6 EMC78694.1 - 2.5e-07 31.1 1.8 0.0019 18.7 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC4_WD40 PF12894.7 EMC78694.1 - 5.6e-06 26.6 0.1 0.0068 16.7 0.2 4.4 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain TPR_2 PF07719.17 EMC78694.1 - 6.6e-06 25.9 8.3 0.053 13.7 0.4 4.0 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMC78694.1 - 1.6e-05 24.5 10.4 0.14 12.0 0.9 4.4 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 EMC78694.1 - 1.6e-05 25.0 2.2 0.032 14.6 0.2 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC78694.1 - 2.8e-05 24.3 4.7 5.4e-05 23.3 4.7 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EMC78694.1 - 3.4e-05 24.3 0.8 0.36 11.8 0.1 2.8 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EMC78694.1 - 4.1e-05 23.2 1.4 0.00024 20.7 0.9 2.2 2 0 0 2 2 2 1 TPR repeat TPR_6 PF13174.6 EMC78694.1 - 0.00043 20.7 0.3 0.31 11.8 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMC78694.1 - 0.06 14.0 2.8 9.1 7.0 0.1 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EMC78694.1 - 0.32 11.3 1.1 10 6.6 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat NTP_transf_7 PF07984.12 EMC78695.1 - 7.6e-143 475.5 0.9 8.7e-143 475.3 0.9 1.0 1 0 0 1 1 1 1 Nucleotidyltransferase CS PF04969.16 EMC78696.1 - 4.4e-19 69.3 0.5 1.8e-18 67.3 0.1 2.2 2 0 0 2 2 2 1 CS domain NuDC PF16273.5 EMC78696.1 - 5.7e-16 58.8 18.6 5.7e-16 58.8 18.6 3.2 2 2 1 3 3 3 1 Nuclear distribution C domain Nudc_N PF14050.6 EMC78696.1 - 1.2e-09 38.1 0.4 4e-09 36.3 0.4 1.9 1 1 0 1 1 1 1 N-terminal conserved domain of Nudc. G-patch PF01585.23 EMC78697.1 - 8.6e-09 35.2 1.3 1.6e-08 34.3 1.3 1.5 1 0 0 1 1 1 1 G-patch domain ATP_bind_1 PF03029.17 EMC78698.1 - 1.5e-86 290.1 0.0 1.8e-86 289.9 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 EMC78698.1 - 0.00037 20.3 0.0 0.00079 19.3 0.0 1.5 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_17 PF13207.6 EMC78698.1 - 0.0059 17.0 0.1 0.13 12.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 EMC78698.1 - 0.0066 15.5 0.0 0.01 14.8 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 EMC78698.1 - 0.0077 16.0 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EMC78698.1 - 0.0091 16.3 0.0 0.029 14.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_31 PF13614.6 EMC78698.1 - 0.0099 15.8 0.0 0.078 12.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EMC78698.1 - 0.012 16.1 0.2 0.18 12.3 0.0 2.5 3 1 0 3 3 3 0 AAA domain AAA_16 PF13191.6 EMC78698.1 - 0.026 14.9 0.0 0.068 13.5 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 EMC78698.1 - 0.053 13.2 0.0 0.25 11.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EMC78698.1 - 0.054 13.7 0.0 0.15 12.2 0.1 1.9 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EMC78698.1 - 0.067 13.6 0.0 0.15 12.5 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA PF00004.29 EMC78698.1 - 0.087 13.2 0.0 0.18 12.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EMC78698.1 - 0.14 12.2 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) 14-3-3 PF00244.20 EMC78699.1 - 6.9e-103 342.9 7.6 7.8e-103 342.7 7.6 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_12 PF13424.6 EMC78699.1 - 0.0097 16.2 0.3 0.34 11.2 0.0 2.6 2 1 1 3 3 3 1 Tetratricopeptide repeat Peptidase_C98 PF15499.6 EMC78699.1 - 0.02 14.3 0.1 0.036 13.5 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase WXG100 PF06013.12 EMC78699.1 - 0.032 14.5 1.3 9.4 6.6 0.0 3.3 4 0 0 4 4 4 0 Proteins of 100 residues with WXG Anticodon_1 PF08264.13 EMC78699.1 - 0.054 13.5 0.1 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 Anticodon-binding domain of tRNA Cdh1_DBD_1 PF18196.1 EMC78699.1 - 0.061 13.6 1.9 1.8 8.9 0.0 2.6 2 1 0 2 2 2 0 Chromodomain helicase DNA-binding domain 1 FliM PF02154.15 EMC78699.1 - 0.14 12.0 0.0 0.31 10.9 0.0 1.6 1 1 0 1 1 1 0 Flagellar motor switch protein FliM DHHC PF01529.20 EMC78700.1 - 8.3e-37 126.3 13.1 1.2e-36 125.8 13.1 1.2 1 0 0 1 1 1 1 DHHC palmitoyltransferase DUF2244 PF10003.9 EMC78700.1 - 1.7 8.3 5.8 16 5.2 1.6 2.3 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) Pkinase PF00069.25 EMC78702.1 - 4.6e-149 495.0 0.0 7.6e-76 255.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMC78702.1 - 4.3e-78 262.2 0.0 1.8e-41 142.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EMC78702.1 - 5.3e-14 52.2 0.0 6.9e-07 28.9 0.0 3.3 2 1 1 3 3 3 2 Kinase-like Kdo PF06293.14 EMC78702.1 - 4.5e-11 42.5 0.0 2e-06 27.3 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMC78702.1 - 4e-09 35.7 0.0 0.00048 19.0 0.0 2.2 2 0 0 2 2 2 2 Fungal protein kinase Haspin_kinase PF12330.8 EMC78702.1 - 1.9e-06 27.1 1.4 0.029 13.3 0.1 2.6 3 0 0 3 3 3 2 Haspin like kinase domain APH PF01636.23 EMC78702.1 - 5.3e-05 23.3 0.0 0.3 11.0 0.0 2.8 2 1 1 3 3 3 2 Phosphotransferase enzyme family FTA2 PF13095.6 EMC78702.1 - 0.00019 21.1 0.1 3.4 7.2 0.0 3.4 3 0 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 EMC78702.1 - 0.0011 18.6 0.0 0.28 10.7 0.0 2.8 3 0 0 3 3 3 1 PhoP regulatory network protein YrbL Pkinase_C PF00433.24 EMC78702.1 - 0.0029 18.3 0.0 0.011 16.5 0.0 2.0 1 0 0 1 1 1 1 Protein kinase C terminal domain tRNA-synt_1f PF01921.18 EMC78702.1 - 0.0035 16.3 0.0 0.007 15.3 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (K) RIO1 PF01163.22 EMC78702.1 - 0.03 13.9 0.0 0.82 9.2 0.0 2.4 2 0 0 2 2 2 0 RIO1 family HMG14_17 PF01101.18 EMC78703.1 - 8.7e-26 90.7 20.4 9.2e-26 90.6 20.4 1.0 1 0 0 1 1 1 1 HMG14 and HMG17 Prenyltransf PF01255.19 EMC78704.1 - 3.4e-77 258.9 0.0 4.7e-77 258.5 0.0 1.2 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase AATase PF07247.12 EMC78704.1 - 0.17 10.4 0.0 0.24 9.9 0.0 1.1 1 0 0 1 1 1 0 Alcohol acetyltransferase DUF5526 PF17664.1 EMC78704.1 - 0.25 10.9 4.0 0.46 10.0 4.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5526) zf-CCHC PF00098.23 EMC78705.1 - 1.9e-07 30.9 10.8 2.5e-05 24.1 3.0 2.3 2 0 0 2 2 2 2 Zinc knuckle CSD PF00313.22 EMC78705.1 - 2e-06 27.6 0.0 3e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain zf-CCHC_4 PF14392.6 EMC78705.1 - 0.0074 16.0 8.6 0.066 12.9 1.5 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_6 PF15288.6 EMC78705.1 - 0.053 13.4 6.2 1.6 8.6 0.7 2.4 2 0 0 2 2 2 0 Zinc knuckle CusF_Ec PF11604.8 EMC78705.1 - 0.1 12.6 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Copper binding periplasmic protein CusF CSD PF00313.22 EMC78706.1 - 0.00088 19.1 0.2 0.0022 17.8 0.2 1.7 1 1 0 1 1 1 1 'Cold-shock' DNA-binding domain SEP PF08059.13 EMC78707.1 - 6.4e-15 55.5 0.3 1.5e-14 54.3 0.0 1.8 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 EMC78707.1 - 1.9e-09 37.6 0.0 9.4e-09 35.4 0.0 2.1 2 0 0 2 2 2 1 UBX domain TMPIT PF07851.13 EMC78707.1 - 0.0037 16.6 1.2 0.0055 16.0 1.2 1.1 1 0 0 1 1 1 1 TMPIT-like protein DUF16 PF01519.16 EMC78707.1 - 0.017 15.6 2.5 0.047 14.2 2.5 1.8 1 0 0 1 1 1 0 Protein of unknown function DUF16 Fib_alpha PF08702.10 EMC78707.1 - 0.049 13.8 1.4 0.26 11.5 1.4 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Nup54 PF13874.6 EMC78707.1 - 0.071 13.2 1.3 0.13 12.4 1.3 1.4 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 ROS_MUCR PF05443.11 EMC78707.1 - 0.16 12.0 0.2 1.2 9.2 0.0 2.1 2 0 0 2 2 2 0 ROS/MUCR transcriptional regulator protein DivIC PF04977.15 EMC78707.1 - 0.22 11.3 6.0 0.063 13.1 2.1 2.0 2 0 0 2 2 2 0 Septum formation initiator FAM76 PF16046.5 EMC78707.1 - 0.23 10.7 4.5 0.36 10.1 4.5 1.2 1 0 0 1 1 1 0 FAM76 protein SH3BGR PF04908.15 EMC78708.1 - 2.4e-38 130.3 0.1 2.7e-38 130.1 0.1 1.0 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 EMC78708.1 - 5.6e-07 29.7 0.0 8.6e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.6 EMC78708.1 - 0.077 13.4 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain PI_PP_I PF18363.1 EMC78709.1 - 5.1 7.3 8.5 3.5 7.9 0.4 3.3 2 1 0 2 2 2 0 Phosphoinositide phosphatase insertion domain TDRP PF15683.5 EMC78711.1 - 4e-06 26.9 0.0 1.4e-05 25.2 0.0 1.8 1 1 1 2 2 2 1 Testis development-related protein FAM110_N PF14161.6 EMC78712.1 - 5.5e-16 58.7 0.0 1.2e-15 57.6 0.0 1.6 1 0 0 1 1 1 1 Centrosome-associated N terminus Herpes_capsid PF06112.11 EMC78712.1 - 0.071 13.2 1.4 0.15 12.1 1.4 1.5 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Cation_efflux PF01545.21 EMC78713.1 - 4.3e-32 111.5 8.5 7.3e-32 110.7 8.5 1.4 1 0 0 1 1 1 1 Cation efflux family Ocular_alb PF02101.15 EMC78713.1 - 0.037 13.0 0.1 0.053 12.4 0.1 1.2 1 0 0 1 1 1 0 Ocular albinism type 1 protein TMEM108 PF15759.5 EMC78714.1 - 5.3e-66 223.7 0.1 6.2e-66 223.5 0.1 1.0 1 0 0 1 1 1 1 TMEM108 family CDV3 PF15359.6 EMC78715.1 - 2.7e-43 147.6 8.0 3.8e-43 147.1 8.0 1.2 1 0 0 1 1 1 1 Carnitine deficiency-associated protein 3 MecA_N PF05223.11 EMC78715.1 - 0.16 12.2 2.4 2.8 8.3 0.6 2.1 2 0 0 2 2 2 0 NTF2-like N-terminal transpeptidase domain BRCT PF00533.26 EMC78716.1 - 4.3e-83 273.7 0.6 1.1e-16 61.0 0.1 8.9 9 0 0 9 9 9 6 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EMC78716.1 - 1.4e-60 201.1 10.9 1.2e-22 79.6 1.2 7.6 7 1 0 7 7 7 5 twin BRCT domain BRCT_2 PF16589.5 EMC78716.1 - 5.7e-33 113.2 0.3 9e-08 32.4 0.0 7.6 7 0 0 7 7 7 6 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EMC78716.1 - 3.6e-20 72.0 2.6 2.6e-06 27.6 0.0 7.1 8 0 0 8 8 8 3 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 EMC78716.1 - 7.4e-17 61.1 0.0 1.8e-05 24.5 0.0 5.9 7 0 0 7 7 7 3 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 EMC78716.1 - 3.7e-05 23.7 0.0 6 7.0 0.0 5.4 6 0 0 6 6 6 1 BRCA1 C Terminus (BRCT) domain 7tm_1 PF00001.21 EMC78717.1 - 1.6e-48 165.3 27.8 1.4e-45 155.6 27.8 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC78717.1 - 4.2e-06 26.3 21.8 9.6e-05 21.9 21.8 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 EMC78718.1 - 3.4e-53 180.7 21.7 4.1e-53 180.4 21.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC78718.1 - 2.2e-08 33.8 22.4 2.8e-08 33.5 22.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx PspC PF04024.12 EMC78718.1 - 0.2 11.5 0.2 0.2 11.5 0.2 2.4 2 1 0 2 2 2 0 PspC domain 7tm_4 PF13853.6 EMC78718.1 - 0.27 10.9 22.0 1.7 8.3 22.0 2.4 1 1 0 1 1 1 0 Olfactory receptor COX7C PF02935.16 EMC78718.1 - 1.8 8.9 5.3 9.4 6.6 1.1 2.9 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIIc 7tm_1 PF00001.21 EMC78719.1 - 1.3e-42 145.9 18.4 1.6e-42 145.7 18.4 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TSR PF18487.1 EMC78719.1 - 0.17 12.1 0.9 3.2 8.1 0.0 2.5 3 0 0 3 3 3 0 Thrombospondin type 1 repeat 7tm_1 PF00001.21 EMC78720.1 - 6.9e-46 156.7 21.8 1.2e-45 155.9 21.8 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC78720.1 - 0.0018 17.7 21.7 0.0025 17.2 21.7 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF3290 PF11694.8 EMC78720.1 - 1 9.3 5.3 3 7.8 5.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) MIF4G PF02854.19 EMC78721.1 - 4.7e-13 49.3 1.3 1e-12 48.2 1.3 1.6 1 0 0 1 1 1 1 MIF4G domain MA3 PF02847.17 EMC78721.1 - 0.00089 19.2 0.0 0.0025 17.8 0.0 1.8 1 0 0 1 1 1 1 MA3 domain CENP-B_dimeris PF09026.10 EMC78721.1 - 0.032 14.6 7.2 0.032 14.6 7.2 2.7 3 0 0 3 3 3 0 Centromere protein B dimerisation domain SDA1 PF05285.12 EMC78721.1 - 5.5 6.3 27.3 2.5 7.4 6.3 2.1 2 0 0 2 2 2 0 SDA1 UQ_con PF00179.26 EMC78722.1 - 8.2e-47 158.4 0.0 1.1e-46 157.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EMC78722.1 - 0.009 15.7 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EMC78722.1 - 0.0094 16.2 0.1 0.015 15.6 0.1 1.4 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 EMC78722.1 - 0.16 11.8 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 UEV domain DUF4663 PF15668.5 EMC78722.1 - 2.4 7.1 5.2 3.4 6.6 5.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4663) Integrin_alpha2 PF08441.12 EMC78723.1 - 5.2e-78 263.0 3.2 6.7e-76 256.1 0.8 2.2 1 1 1 2 2 2 2 Integrin alpha FG-GAP PF01839.23 EMC78723.1 - 1.5e-20 73.0 14.5 1.7e-09 37.7 0.0 4.1 4 0 0 4 4 4 3 FG-GAP repeat VCBS PF13517.6 EMC78723.1 - 1.1e-11 45.2 5.3 8.9e-08 32.6 0.1 2.8 1 1 1 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.20 EMC78723.1 - 0.00075 19.3 0.5 0.0016 18.3 0.5 1.6 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region AlgF PF11182.8 EMC78723.1 - 0.0091 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Alginate O-acetyl transferase AlgF Spp-24 PF07448.11 EMC78724.1 - 6e-20 71.2 0.3 9.1e-20 70.6 0.3 1.3 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Cathelicidins PF00666.17 EMC78724.1 - 1.8e-08 34.6 0.0 2.6e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Cathelicidin Cystatin PF00031.21 EMC78724.1 - 0.0025 18.0 0.0 0.0038 17.5 0.0 1.3 1 0 0 1 1 1 1 Cystatin domain Arf PF00025.21 EMC78725.1 - 9.5e-62 207.5 0.0 1.1e-61 207.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EMC78725.1 - 6.1e-16 58.7 0.0 8.1e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMC78725.1 - 2e-15 56.8 0.0 2.5e-15 56.5 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EMC78725.1 - 5.6e-11 42.2 0.0 8.6e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EMC78725.1 - 3e-08 33.2 0.1 1.5e-05 24.4 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 EMC78725.1 - 9.2e-08 32.2 0.0 1.2e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC78725.1 - 0.0006 19.4 0.0 0.002 17.7 0.0 1.7 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EMC78725.1 - 0.0027 17.1 0.0 0.0037 16.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region 6PF2K PF01591.18 EMC78725.1 - 0.061 12.6 0.0 0.088 12.1 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase cobW PF02492.19 EMC78725.1 - 0.15 11.7 0.0 1.2 8.7 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SH3_2 PF07653.17 EMC78726.1 - 2.1e-22 78.6 0.1 8.7e-11 41.3 0.2 3.3 3 0 0 3 3 3 2 Variant SH3 domain SH3_1 PF00018.28 EMC78726.1 - 8.1e-10 38.2 0.5 6.3e-09 35.3 0.0 2.7 2 1 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EMC78726.1 - 1.1e-09 37.9 0.2 1.1e-08 34.8 0.0 2.4 2 0 0 2 2 2 1 Variant SH3 domain ZU5 PF00791.20 EMC78726.1 - 3.7e-08 33.6 0.2 7.9e-08 32.6 0.2 1.5 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 EMC78726.1 - 0.0039 17.3 1.4 0.75 10.0 0.1 3.5 2 1 1 3 3 3 1 Death domain UDPGT PF00201.18 EMC78727.1 - 1.2e-191 637.8 0.1 1.5e-191 637.6 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EMC78727.1 - 4.3e-06 26.8 0.0 9.6e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Herpes_LMP2 PF07415.11 EMC78727.1 - 0.07 11.9 0.8 0.1 11.4 0.8 1.2 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein Pro_3_hydrox_C PF05373.11 EMC78727.1 - 0.16 12.0 0.0 0.34 11.0 0.0 1.5 1 0 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal RhoGAP PF00620.27 EMC78728.1 - 6.9e-15 55.2 3.2 8.6e-07 28.9 0.1 5.0 3 1 2 5 5 5 4 RhoGAP domain Trypan_PARP PF05887.11 EMC78729.1 - 0.00056 19.9 24.5 0.00077 19.4 24.5 1.2 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Mpp10 PF04006.12 EMC78729.1 - 0.0037 15.8 35.2 0.0047 15.5 35.2 1.0 1 0 0 1 1 1 1 Mpp10 protein CDC45 PF02724.14 EMC78729.1 - 0.049 11.9 27.9 0.058 11.7 27.9 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4045 PF13254.6 EMC78729.1 - 0.057 13.1 25.1 0.067 12.8 25.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Velvet PF11754.8 EMC78729.1 - 0.4 10.6 7.7 0.52 10.2 7.7 1.1 1 0 0 1 1 1 0 Velvet factor SAPS PF04499.15 EMC78729.1 - 1.1 7.9 19.5 1.2 7.8 19.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PA26 PF04636.13 EMC78729.1 - 4.9 6.0 16.2 6.1 5.6 16.2 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF913 PF06025.12 EMC78729.1 - 5.5 5.9 16.1 6.9 5.5 16.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Hid1 PF12722.7 EMC78729.1 - 6.9 4.7 18.8 7.5 4.5 18.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CobT PF06213.12 EMC78729.1 - 7.4 5.9 29.1 11 5.3 29.1 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SID-1_RNA_chan PF13965.6 EMC78729.1 - 7.5 4.8 9.5 8.6 4.6 9.5 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 GAGA_bind PF06217.12 EMC78729.1 - 9.8 6.4 24.9 14 5.9 24.9 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family zf-C3HC4_3 PF13920.6 EMC78730.1 - 3e-11 43.0 7.2 5.4e-11 42.2 7.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC78730.1 - 1.8e-09 37.3 9.2 3.6e-09 36.4 9.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC78730.1 - 3.2e-09 37.0 11.4 7.2e-09 35.8 11.4 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC78730.1 - 1e-08 34.9 10.4 1.8e-08 34.1 10.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMC78730.1 - 2.2e-07 31.1 9.3 4.9e-07 29.9 9.3 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EMC78730.1 - 5.8e-06 26.2 5.1 5.8e-06 26.2 5.1 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMC78730.1 - 1.1e-05 25.3 7.0 2.1e-05 24.4 7.0 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC78730.1 - 5.8e-05 22.9 11.8 0.00095 19.0 11.7 2.3 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 EMC78730.1 - 0.00092 19.3 1.9 0.0021 18.2 1.9 1.6 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-C3HC4_4 PF15227.6 EMC78730.1 - 0.0015 18.7 8.7 0.0043 17.2 8.7 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 EMC78730.1 - 0.0077 16.3 5.5 0.016 15.3 5.5 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Rad50_zn_hook PF04423.14 EMC78730.1 - 0.013 15.3 0.8 0.16 11.8 0.1 2.4 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-MIZ PF02891.20 EMC78730.1 - 0.079 12.7 0.2 0.079 12.7 0.2 2.5 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger zf-RING_4 PF14570.6 EMC78730.1 - 0.13 12.1 9.9 0.77 9.6 10.3 2.0 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Vps36-NZF-N PF16988.5 EMC78730.1 - 6.7 6.2 7.7 17 4.9 7.8 1.7 1 1 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain HU-CCDC81_euk_2 PF18289.1 EMC78731.1 - 2.4e-08 34.0 0.0 5.6e-08 32.8 0.0 1.6 2 0 0 2 2 2 1 CCDC81 eukaryotic HU domain 2 HU-CCDC81_euk_1 PF14908.6 EMC78731.1 - 1.1e-07 31.8 0.0 1.5e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 1 DUF2099 PF09872.9 EMC78731.1 - 0.083 12.1 0.1 1.4 8.1 0.1 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2099) Rad17 PF03215.15 EMC78732.1 - 3.6e-61 206.4 0.0 6.9e-61 205.4 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 EMC78732.1 - 2.5e-06 28.0 0.0 7.1e-06 26.5 0.0 1.7 2 0 0 2 2 1 1 AAA ATPase domain AAA PF00004.29 EMC78732.1 - 1.6e-05 25.3 0.0 3.7e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EMC78732.1 - 6.9e-05 22.6 0.0 0.00014 21.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EMC78732.1 - 0.0001 22.9 0.0 0.00027 21.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EMC78732.1 - 0.00018 21.8 0.0 0.00048 20.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EMC78732.1 - 0.0037 17.3 0.0 0.0079 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) TsaE PF02367.17 EMC78732.1 - 0.0051 16.8 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_assoc_2 PF16193.5 EMC78732.1 - 0.0052 17.1 0.0 0.013 15.9 0.0 1.7 1 0 0 1 1 1 1 AAA C-terminal domain AAA_7 PF12775.7 EMC78732.1 - 0.007 15.9 0.0 0.016 14.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_19 PF13245.6 EMC78732.1 - 0.0099 16.2 0.0 0.026 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EMC78732.1 - 0.02 15.3 0.1 0.11 12.9 0.0 2.3 2 1 0 2 2 2 0 RNA helicase DMA PF03474.14 EMC78732.1 - 0.043 13.4 0.0 0.25 11.0 0.0 2.3 2 0 0 2 2 2 0 DMRTA motif Zeta_toxin PF06414.12 EMC78732.1 - 0.045 13.0 0.0 0.072 12.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_11 PF13086.6 EMC78732.1 - 0.051 13.4 0.2 0.2 11.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EMC78732.1 - 0.059 13.6 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EMC78732.1 - 0.092 12.7 0.3 0.46 10.4 0.3 2.3 2 1 0 2 2 2 0 NACHT domain Mg_chelatase PF01078.21 EMC78732.1 - 0.12 11.8 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 EMC78732.1 - 0.13 11.5 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_14 PF13173.6 EMC78732.1 - 0.14 12.1 0.0 0.33 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EMC78733.1 - 1.3e-24 87.2 0.0 1.9e-24 86.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EMC78733.1 - 2.4e-05 24.8 0.1 5.7e-05 23.6 0.1 1.8 1 1 1 2 2 2 1 AAA domain SKI PF01202.22 EMC78733.1 - 0.00016 21.9 0.5 0.015 15.4 0.1 2.4 2 1 0 2 2 2 1 Shikimate kinase AAA PF00004.29 EMC78733.1 - 0.03 14.7 0.0 0.05 14.0 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Cytidylate_kin PF02224.18 EMC78733.1 - 0.048 13.4 0.0 0.075 12.8 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase Cytidylate_kin2 PF13189.6 EMC78733.1 - 0.063 13.4 0.0 0.08 13.1 0.0 1.4 1 1 0 1 1 1 0 Cytidylate kinase-like family SbcD_C PF12320.8 EMC78734.1 - 0.046 14.0 1.9 0.046 14.0 1.9 2.9 3 0 0 3 3 3 0 Type 5 capsule protein repressor C-terminal domain Cas_Csa4 PF09703.10 EMC78734.1 - 0.17 11.1 4.3 1.3 8.3 0.3 2.5 2 1 1 3 3 3 0 CRISPR-associated protein (Cas_Csa4) DMPK_coil PF08826.10 EMC78734.1 - 8.7 6.5 24.5 0.96 9.6 0.7 4.8 5 0 0 5 5 5 0 DMPK coiled coil domain like DUF3480 PF11979.8 EMC78735.1 - 9.9e-156 518.1 0.1 2.2e-155 516.9 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3480) FYVE PF01363.21 EMC78735.1 - 1.1e-18 67.2 15.0 3.1e-18 65.7 15.0 1.9 1 0 0 1 1 1 1 FYVE zinc finger DUF2181 PF10223.9 EMC78736.1 - 5.7e-72 242.1 0.6 1.6e-70 237.3 0.6 2.0 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2181) Ank_2 PF12796.7 EMC78737.1 - 2.9e-25 88.7 0.2 9.4e-15 55.0 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC78737.1 - 6.5e-20 71.2 0.1 7e-07 29.7 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EMC78737.1 - 6.8e-16 57.9 0.0 4.9e-06 26.7 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EMC78737.1 - 8.7e-13 48.2 0.1 4.4e-06 26.9 0.0 3.8 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC78737.1 - 2.4e-11 42.8 0.0 0.00017 21.8 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat DHFR_1 PF00186.19 EMC78738.1 - 1.7e-26 92.8 0.0 2.1e-26 92.5 0.0 1.0 1 0 0 1 1 1 1 Dihydrofolate reductase MutS_I PF01624.20 EMC78739.1 - 2.2e-33 114.9 0.2 3.1e-33 114.4 0.2 1.2 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EMC78739.1 - 9.7e-12 45.3 0.3 3.9e-11 43.4 0.0 2.1 3 0 0 3 3 3 1 MutS domain II MutS_V PF00488.21 EMC78740.1 - 9.8e-73 244.2 0.1 3.4e-72 242.5 0.0 1.9 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 EMC78740.1 - 1.7e-35 123.0 0.1 6.6e-35 121.1 0.0 2.0 2 1 0 2 2 2 1 MutS domain III MutS_II PF05188.17 EMC78740.1 - 5e-11 43.0 0.1 3.4e-10 40.4 0.0 2.2 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 EMC78740.1 - 0.00032 21.0 0.1 0.0012 19.1 0.1 2.0 1 0 0 1 1 1 1 MutS family domain IV NPV_P10 PF05531.12 EMC78740.1 - 0.39 11.2 3.7 6.6 7.3 0.0 2.9 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein AAA_23 PF13476.6 EMC78740.1 - 0.84 10.1 6.2 13 6.2 1.1 3.1 3 0 0 3 3 3 0 AAA domain RasGEF PF00617.19 EMC78741.1 - 2.4e-48 164.7 0.1 6.6e-48 163.2 0.1 1.8 1 0 0 1 1 1 1 RasGEF domain RhoGEF PF00621.20 EMC78741.1 - 8.3e-32 110.9 2.9 8.3e-32 110.9 2.9 2.5 2 0 0 2 2 2 1 RhoGEF domain RasGEF_N PF00618.20 EMC78741.1 - 1.7e-24 86.1 0.2 2.1e-18 66.5 0.1 3.2 2 0 0 2 2 2 2 RasGEF N-terminal motif PH PF00169.29 EMC78741.1 - 5.1e-08 33.4 0.0 0.00035 21.1 0.0 2.7 2 0 0 2 2 2 2 PH domain PH_17 PF18012.1 EMC78741.1 - 0.007 16.1 0.0 0.077 12.7 0.0 2.6 2 0 0 2 2 2 1 PH domain IQ PF00612.27 EMC78741.1 - 0.01 15.6 1.8 0.024 14.4 1.8 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif SAM_DrpA PF18255.1 EMC78741.1 - 0.14 12.4 1.3 9.4 6.6 0.0 3.3 3 0 0 3 3 3 0 DNA processing protein A sterile alpha motif domain DUF641 PF04859.12 EMC78741.1 - 0.55 10.6 7.0 0.067 13.5 2.1 1.9 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) DUF3450 PF11932.8 EMC78741.1 - 6.8 5.9 13.0 0.065 12.5 2.8 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) ATP-gua_Ptrans PF00217.19 EMC78742.1 - 1.1e-81 273.4 0.0 1.3e-81 273.1 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.15 EMC78742.1 - 1.3e-30 105.6 0.0 2.2e-30 104.8 0.0 1.4 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain zf-CCHC PF00098.23 EMC78743.1 - 7.9e-18 63.6 24.8 1.9e-06 27.7 0.6 4.3 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_2 PF13696.6 EMC78743.1 - 4.2e-09 36.1 22.5 0.00021 21.0 0.3 4.2 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_4 PF14392.6 EMC78743.1 - 0.0014 18.3 21.7 0.32 10.8 0.6 4.4 4 0 0 4 4 4 4 Zinc knuckle Prim_Zn_Ribbon PF08273.12 EMC78743.1 - 0.019 15.2 6.3 1.6 9.1 0.1 3.4 3 0 0 3 3 3 0 Zinc-binding domain of primase-helicase zf-CCHC_5 PF14787.6 EMC78743.1 - 0.021 14.5 0.2 0.021 14.5 0.2 3.6 4 0 0 4 4 4 0 GAG-polyprotein viral zinc-finger zf-C2H2_10 PF16588.5 EMC78743.1 - 0.15 11.8 0.0 0.15 11.8 0.0 3.2 4 0 0 4 4 4 0 C2H2 zinc-finger PHD_4 PF16866.5 EMC78743.1 - 0.78 9.9 11.9 0.44 10.7 1.2 3.0 1 1 2 3 3 3 0 PHD-finger zf-CCHC_3 PF13917.6 EMC78743.1 - 2.7 8.0 15.0 5.2 7.1 0.6 4.1 2 1 2 4 4 4 0 Zinc knuckle DZR PF12773.7 EMC78743.1 - 7.2 6.7 13.3 1.2e+03 -0.4 13.3 3.0 1 1 0 1 1 1 0 Double zinc ribbon START PF01852.19 EMC78744.1 - 1.7e-19 70.1 0.1 2e-19 69.8 0.1 1.1 1 0 0 1 1 1 1 START domain Polyketide_cyc2 PF10604.9 EMC78744.1 - 0.015 15.6 0.0 0.029 14.7 0.0 1.4 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport DUF5546 PF17700.1 EMC78744.1 - 0.06 13.7 0.2 0.1 13.0 0.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5546) 4HBT PF03061.22 EMC78745.1 - 6.4e-25 87.3 0.3 2.5e-11 43.7 0.1 2.3 2 0 0 2 2 2 2 Thioesterase superfamily SSDP PF04503.13 EMC78746.1 - 1.3e-74 252.1 75.8 2.2e-59 202.1 64.2 2.0 1 1 1 2 2 2 2 Single-stranded DNA binding protein, SSDP Autophagy_act_C PF03987.15 EMC78747.1 - 6.2e-20 71.5 0.7 1.1e-19 70.7 0.7 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Ribosom_S12_S23 PF00164.25 EMC78748.1 - 1.2e-52 176.3 0.9 1.5e-52 176.0 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 ATP-synt_S1 PF05827.12 EMC78749.1 - 2.3e-47 160.5 1.0 2.8e-47 160.2 1.0 1.1 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) DUF3941 PF13081.6 EMC78749.1 - 0.18 12.3 0.2 0.39 11.2 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3941) VMA21 PF09446.10 EMC78750.1 - 4e-11 42.8 4.0 4.4e-11 42.7 4.0 1.0 1 0 0 1 1 1 1 VMA21-like domain DUF4134 PF13572.6 EMC78750.1 - 0.023 15.0 0.1 0.025 14.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4134) PAS_11 PF14598.6 EMC78751.1 - 1.2e-21 76.9 0.0 2.5e-19 69.5 0.0 2.9 2 0 0 2 2 2 1 PAS domain PAS_3 PF08447.12 EMC78751.1 - 4.2e-20 71.8 0.1 3.3e-16 59.3 0.1 2.9 3 0 0 3 3 3 2 PAS fold PAS PF00989.25 EMC78751.1 - 2.3e-11 43.7 0.0 4.6e-08 33.1 0.0 3.3 4 0 0 4 4 4 2 PAS fold HLH PF00010.26 EMC78751.1 - 9.1e-11 41.6 0.8 1.8e-10 40.6 0.8 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.7 EMC78751.1 - 0.00019 21.7 0.0 0.00096 19.4 0.0 2.2 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 EMC78751.1 - 0.098 12.9 0.1 0.74 10.1 0.0 2.5 3 0 0 3 3 3 0 PAS fold Meis_PKNOX_N PF16493.5 EMC78751.1 - 0.39 11.1 3.4 7.9 6.9 0.1 3.2 3 0 0 3 3 3 0 N-terminal of Homeobox Meis and PKNOX1 DDRGK PF09756.9 EMC78751.1 - 3.3 7.3 8.2 0.52 9.9 1.8 2.1 2 0 0 2 2 2 0 DDRGK domain RabGAP-TBC PF00566.18 EMC78752.1 - 9e-44 149.7 0.0 9e-44 149.7 0.0 2.4 4 0 0 4 4 4 1 Rab-GTPase-TBC domain GRAM PF02893.20 EMC78752.1 - 2.6e-33 114.3 1.4 5.2e-19 68.2 0.2 2.5 2 0 0 2 2 2 2 GRAM domain PA PF02225.22 EMC78753.1 - 4.3e-07 29.9 0.1 6.7e-07 29.2 0.1 1.3 1 0 0 1 1 1 1 PA domain zf-rbx1 PF12678.7 EMC78753.1 - 1.1e-06 28.8 7.3 2.6e-06 27.6 7.3 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EMC78753.1 - 1.9e-05 24.9 9.5 4.9e-05 23.6 9.5 1.8 1 0 0 1 1 1 1 Ring finger domain zf-ANAPC11 PF12861.7 EMC78753.1 - 0.0029 17.6 4.6 0.006 16.6 4.6 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 EMC78753.1 - 0.02 14.7 9.4 0.047 13.5 9.4 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EMC78753.1 - 0.079 12.6 7.7 0.16 11.7 7.7 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4 PF00097.25 EMC78753.1 - 0.22 11.4 8.8 0.57 10.1 8.9 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF5521 PF17659.1 EMC78754.1 - 7.2e-55 186.3 0.2 8e-55 186.1 0.2 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5521) DUF5521 PF17659.1 EMC78755.1 - 1.4e-181 605.4 1.2 1.6e-181 605.3 1.2 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5521) DUF5088 PF17008.5 EMC78755.1 - 0.001 18.8 0.1 0.0032 17.2 0.0 1.9 2 1 0 2 2 2 1 Domain of unknown function (DUF5088) Eryth_link_C PF16915.5 EMC78755.1 - 0.04 13.9 0.1 0.087 12.8 0.1 1.5 1 0 0 1 1 1 0 Annelid erythrocruorin linker subunit C-terminus CDC24_OB3 PF17244.2 EMC78755.1 - 0.064 13.0 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 3 tRNA_anti-codon PF01336.25 EMC78755.1 - 0.078 13.0 0.0 0.28 11.2 0.0 2.0 2 0 0 2 2 2 0 OB-fold nucleic acid binding domain DUF4539 PF15072.6 EMC78755.1 - 0.094 12.8 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4539) Pkinase PF00069.25 EMC78756.1 - 5.1e-62 209.6 0.0 8.8e-62 208.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain CNH PF00780.22 EMC78756.1 - 1e-54 186.0 0.0 1.9e-54 185.2 0.0 1.5 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.17 EMC78756.1 - 9.3e-46 156.2 0.0 1.5e-45 155.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC78756.1 - 0.00031 20.2 0.0 0.0022 17.4 0.0 2.2 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EMC78756.1 - 0.3 11.0 0.0 0.3 11.0 0.0 2.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family TIR PF01582.20 EMC78757.1 - 1.4e-31 109.6 0.1 3.5e-31 108.4 0.1 1.7 1 0 0 1 1 1 1 TIR domain Ig_2 PF13895.6 EMC78757.1 - 2.9e-21 75.6 0.0 5.4e-08 33.1 0.1 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_6 PF18452.1 EMC78757.1 - 3.4e-21 74.6 0.0 1.1e-14 53.7 0.1 3.5 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 EMC78757.1 - 7.8e-21 73.9 0.0 1e-05 25.5 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC78757.1 - 2.1e-19 69.9 0.0 5.9e-06 26.8 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 EMC78757.1 - 5.4e-17 61.7 0.0 3e-05 24.1 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 EMC78757.1 - 1.6e-10 41.1 0.0 0.18 12.0 0.0 5.0 3 2 0 3 3 3 3 Immunoglobulin V-set domain TIR_2 PF13676.6 EMC78757.1 - 6.6e-07 29.9 0.0 1.4e-06 28.9 0.0 1.5 1 0 0 1 1 1 1 TIR domain Izumo-Ig PF16706.5 EMC78757.1 - 9.4e-05 22.4 0.2 0.17 12.0 0.0 3.4 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain V-set_CD47 PF08204.11 EMC78757.1 - 0.00027 20.9 2.2 0.076 13.0 0.1 3.5 4 0 0 4 4 4 1 CD47 immunoglobulin-like domain OAR PF03826.17 EMC78758.1 - 1.1e-09 37.8 4.0 2e-09 37.0 4.0 1.5 1 0 0 1 1 1 1 OAR domain FAM199X PF15814.5 EMC78759.1 - 9.2e-206 682.2 21.9 1e-205 682.0 21.9 1.0 1 0 0 1 1 1 1 Protein family FAM199X Macoilin PF09726.9 EMC78759.1 - 0.054 12.0 11.6 0.065 11.8 11.6 1.1 1 0 0 1 1 1 0 Macoilin family Med3 PF11593.8 EMC78759.1 - 0.28 10.3 5.3 0.38 9.9 5.3 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal COMM_domain PF07258.14 EMC78760.1 - 9e-18 64.2 0.7 2.8e-17 62.6 0.1 2.0 2 0 0 2 2 2 1 COMM domain HOCHOB PF17943.1 EMC78760.1 - 0.084 13.6 0.0 0.68 10.7 0.0 2.2 2 1 0 2 2 2 0 Homeobox-cysteine loop-homeobox DUF3789 PF12664.7 EMC78761.1 - 6.7e-05 22.5 24.8 50 3.7 0.2 11.8 1 1 12 13 13 13 1 Protein of unknown function (DUF3789) Yae1_N PF09811.9 EMC78761.1 - 0.22 11.3 24.6 18 5.1 0.8 5.6 1 1 5 6 6 6 0 Essential protein Yae1, N terminal TraN PF06986.11 EMC78762.1 - 0.015 15.0 0.9 0.045 13.4 0.6 1.9 1 1 1 2 2 2 0 Type-1V conjugative transfer system mating pair stabilisation Cyt-b5 PF00173.28 EMC78763.1 - 0.02 15.0 0.0 0.029 14.5 0.0 1.2 1 0 0 1 1 1 0 Cytochrome b5-like Heme/Steroid binding domain DUF4164 PF13747.6 EMC78764.1 - 0.25 11.6 2.2 0.3 11.4 1.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) SOAR PF16533.5 EMC78764.1 - 0.87 9.6 4.9 2.2 8.3 4.9 1.7 1 0 0 1 1 1 0 STIM1 Orai1-activating region Dynein_light PF01221.18 EMC78765.1 - 1.3e-30 105.5 0.8 1.4e-30 105.4 0.8 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Dynein_light PF01221.18 EMC78766.1 - 5.3e-36 122.8 0.7 5.8e-36 122.7 0.7 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Nucleopor_Nup85 PF07575.13 EMC78766.1 - 0.099 11.2 0.1 0.11 11.1 0.1 1.0 1 0 0 1 1 1 0 Nup85 Nucleoporin Mito_carr PF00153.27 EMC78767.1 - 2.4e-55 184.5 0.4 3.8e-25 87.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EMC78767.1 - 0.0094 15.1 0.4 0.06 12.5 0.0 2.3 2 1 1 3 3 3 1 Gammaproteobacterial serine protease DUF4410 PF14366.6 EMC78768.1 - 0.31 10.9 2.9 0.61 10.0 2.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4410) UQ_con PF00179.26 EMC78769.1 - 1.5e-40 138.1 0.1 1.6e-40 138.0 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EMC78769.1 - 0.00011 22.4 0.1 0.00014 22.2 0.1 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 EMC78769.1 - 0.0081 15.9 0.0 0.0096 15.6 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EMC78769.1 - 0.0098 15.7 0.1 0.015 15.1 0.1 1.3 1 0 0 1 1 1 1 UEV domain DUF5487 PF17589.2 EMC78769.1 - 0.045 14.0 0.0 0.077 13.3 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5487) DUF2121 PF09894.9 EMC78769.1 - 0.16 11.5 0.0 0.19 11.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2121) G-patch PF01585.23 EMC78770.1 - 5.3e-13 48.6 2.4 5.3e-13 48.6 2.4 1.9 2 0 0 2 2 2 1 G-patch domain dsrm PF00035.26 EMC78770.1 - 6.6e-11 42.8 5.2 0.00014 22.4 0.1 4.2 4 0 0 4 4 4 2 Double-stranded RNA binding motif R3H PF01424.22 EMC78770.1 - 2.5e-07 30.6 0.2 6.7e-07 29.2 0.2 1.8 1 0 0 1 1 1 1 R3H domain G-patch_2 PF12656.7 EMC78770.1 - 2.3e-05 24.4 1.0 8.3e-05 22.6 1.0 2.0 1 0 0 1 1 1 1 G-patch domain Septin PF00735.18 EMC78771.1 - 1.3e-95 319.9 0.5 1.3e-95 319.9 0.5 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EMC78771.1 - 0.0002 21.4 1.0 0.00038 20.5 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EMC78771.1 - 0.0016 18.9 0.3 0.014 15.7 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain Roc PF08477.13 EMC78771.1 - 0.002 18.3 0.0 0.0059 16.8 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 EMC78771.1 - 0.0021 18.4 1.2 0.0048 17.2 0.0 2.2 2 1 0 2 2 2 1 AAA domain GTP_EFTU PF00009.27 EMC78771.1 - 0.003 17.1 2.9 1.4 8.4 0.0 3.2 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain AAA_29 PF13555.6 EMC78771.1 - 0.016 15.0 0.0 0.033 13.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Atg14 PF10186.9 EMC78771.1 - 0.022 13.9 13.2 0.038 13.1 13.2 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_7 PF12775.7 EMC78771.1 - 0.052 13.1 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region IMD PF08397.11 EMC78771.1 - 0.062 12.7 13.9 0.13 11.7 13.9 1.4 1 0 0 1 1 1 0 IRSp53/MIM homology domain DUF1890 PF09001.11 EMC78771.1 - 0.098 13.1 0.2 0.24 11.8 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1890) Fzo_mitofusin PF04799.13 EMC78771.1 - 0.23 11.0 9.9 0.11 12.1 7.5 1.7 2 0 0 2 2 2 0 fzo-like conserved region FtsK_SpoIIIE PF01580.18 EMC78771.1 - 0.47 9.8 3.1 4 6.7 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family RsgA_GTPase PF03193.16 EMC78771.1 - 0.73 9.7 0.0 0.73 9.7 0.0 3.0 3 1 0 3 3 3 0 RsgA GTPase Exonuc_VII_L PF02601.15 EMC78771.1 - 1 8.9 10.4 1.4 8.4 10.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF87 PF01935.17 EMC78771.1 - 1.1 9.3 8.3 3.1 7.8 0.0 2.7 3 0 0 3 3 3 0 Helicase HerA, central domain Dynamin_N PF00350.23 EMC78771.1 - 2.4 8.2 6.2 28 4.7 0.1 2.5 2 1 0 2 2 2 0 Dynamin family ABC_tran PF00005.27 EMC78771.1 - 3.2 8.3 6.2 0.4 11.2 0.2 2.4 2 2 0 2 2 2 0 ABC transporter Ribosomal_L39 PF00832.20 EMC78772.1 - 3.4e-24 84.2 11.0 3.8e-24 84.0 11.0 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein Smg4_UPF3 PF03467.15 EMC78773.1 - 2.3e-39 135.2 5.4 2.3e-39 135.2 5.4 5.3 1 1 4 5 5 5 1 Smg-4/UPF3 family MWFE PF15879.5 EMC78774.1 - 2.4e-10 40.4 0.1 2.6e-10 40.3 0.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit Mg_trans_NIPA PF05653.14 EMC78775.1 - 9.5e-77 258.0 7.8 1.1e-76 257.7 7.8 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EMC78775.1 - 6.4e-09 36.1 8.9 9e-09 35.6 3.9 2.2 2 0 0 2 2 2 1 EamA-like transporter family COX6C PF02937.15 EMC78775.1 - 0.0086 16.2 0.3 2.4 8.3 0.0 3.2 3 0 0 3 3 3 1 Cytochrome c oxidase subunit VIc DUF1295 PF06966.12 EMC78775.1 - 2.5 7.5 4.5 1.6 8.2 1.9 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF1295) TAFII55_N PF04658.13 EMC78776.1 - 7.8e-57 191.5 1.4 7.8e-57 191.5 1.4 2.1 2 1 0 2 2 2 1 TAFII55 protein conserved region DoxX_2 PF13564.6 EMC78778.1 - 9.7e-08 32.1 2.2 1.5e-07 31.5 2.2 1.2 1 0 0 1 1 1 1 DoxX-like family DUF4131 PF13567.6 EMC78778.1 - 0.01 15.5 0.8 0.23 11.1 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) SID-1_RNA_chan PF13965.6 EMC78778.1 - 0.019 13.4 0.5 0.024 13.1 0.5 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Ac76 PF05814.11 EMC78778.1 - 0.18 11.8 0.2 0.18 11.8 0.2 1.7 2 0 0 2 2 2 0 Orf76 (Ac76) HCV_NS2 PF01538.18 EMC78778.1 - 0.18 11.4 1.6 0.24 11.0 1.6 1.2 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein NS2 DKCLD PF08068.12 EMC78779.1 - 5.3e-24 84.1 0.1 1.2e-23 82.9 0.1 1.7 1 0 0 1 1 1 1 DKCLD (NUC011) domain TruB_C_2 PF16198.5 EMC78779.1 - 3.7e-22 78.2 0.3 6.6e-22 77.4 0.3 1.4 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain TruB_N PF01509.18 EMC78779.1 - 7.9e-21 75.0 5.6 2.9e-19 69.9 0.1 3.6 2 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 EMC78779.1 - 2.7e-14 52.9 0.6 7.1e-14 51.5 0.6 1.8 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 EMC78779.1 - 0.031 14.5 0.0 0.083 13.2 0.0 1.7 1 0 0 1 1 1 0 UPF0113 PUA domain FKS1_dom1 PF14288.6 EMC78779.1 - 0.43 10.9 0.0 0.43 10.9 0.0 1.8 2 0 0 2 2 2 0 1,3-beta-glucan synthase subunit FKS1, domain-1 PBP_N PF17093.5 EMC78779.1 - 3.2 8.0 8.2 5.7 7.2 8.2 1.3 1 0 0 1 1 1 0 Penicillin-binding protein N-terminus RNA_polI_A34 PF08208.11 EMC78779.1 - 6 6.9 30.9 10 6.1 30.9 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF908 PF06012.12 EMC78779.1 - 6.3 6.1 7.8 9.1 5.6 7.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Guanylate_kin PF00625.21 EMC78780.1 - 6.1e-61 205.3 0.5 8.9e-61 204.7 0.1 1.5 2 0 0 2 2 2 1 Guanylate kinase PDZ PF00595.24 EMC78780.1 - 1.7e-19 70.0 2.8 2.3e-19 69.5 1.0 2.0 2 0 0 2 2 2 1 PDZ domain SH3_2 PF07653.17 EMC78780.1 - 2.6e-10 39.8 0.0 6.5e-10 38.6 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC78780.1 - 2.3e-08 33.5 0.9 1.1e-07 31.3 0.9 2.1 1 1 0 1 1 1 1 SH3 domain PDZ_6 PF17820.1 EMC78780.1 - 6.3e-06 25.9 0.5 1.7e-05 24.6 0.1 2.0 2 0 0 2 2 2 1 PDZ domain SH3_9 PF14604.6 EMC78780.1 - 4.7e-05 23.1 0.0 0.00011 21.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain PDZ_2 PF13180.6 EMC78780.1 - 0.00012 22.3 0.2 0.00095 19.5 0.1 2.2 2 0 0 2 2 2 1 PDZ domain RsgA_GTPase PF03193.16 EMC78780.1 - 0.0011 18.9 0.0 0.0072 16.3 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase Tricorn_PDZ PF14685.6 EMC78780.1 - 0.0034 17.3 0.4 0.23 11.5 0.1 3.1 3 1 0 3 3 3 1 Tricorn protease PDZ domain AAA_7 PF12775.7 EMC78780.1 - 0.032 13.7 0.0 0.072 12.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region MMR_HSR1 PF01926.23 EMC78780.1 - 0.032 14.3 0.0 0.073 13.2 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase TolB_like PF15869.5 EMC78780.1 - 0.04 13.2 0.0 0.066 12.4 0.0 1.3 1 0 0 1 1 1 0 TolB-like 6-blade propeller-like PDZ_4 PF17816.1 EMC78780.1 - 0.04 14.3 0.1 0.18 12.2 0.0 2.1 2 0 0 2 2 2 0 PDZ domain F5_F8_type_C PF00754.25 EMC78781.1 - 5.8e-55 184.8 5.1 6.1e-27 94.2 0.5 2.7 2 0 0 2 2 2 2 F5/8 type C domain Cu-oxidase_3 PF07732.15 EMC78781.1 - 4.9e-17 62.0 0.0 0.00024 21.1 0.0 4.6 4 0 0 4 4 4 3 Multicopper oxidase Cu-oxidase_2 PF07731.14 EMC78781.1 - 1.7e-13 50.5 8.4 6.7e-09 35.6 1.2 5.0 5 1 0 5 5 5 3 Multicopper oxidase Muskelin_N PF06588.11 EMC78781.1 - 0.014 15.3 0.1 0.05 13.5 0.0 1.8 2 0 0 2 2 2 0 Muskelin N-terminus FUN14 PF04930.15 EMC78782.1 - 4.3e-26 91.2 4.7 5.5e-26 90.8 4.7 1.1 1 0 0 1 1 1 1 FUN14 family SH3BGR PF04908.15 EMC78782.1 - 0.08 13.1 0.0 12 6.1 0.1 2.2 2 0 0 2 2 2 0 SH3-binding, glutamic acid-rich protein SPC12 PF06645.13 EMC78782.1 - 0.31 11.2 2.6 0.25 11.5 0.3 2.0 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) MTCP1 PF08991.10 EMC78783.1 - 1.3e-09 38.2 6.1 1.5e-09 37.9 6.1 1.1 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type TCL1_MTCP1 PF01840.17 EMC78784.1 - 1.2e-16 60.4 0.1 1.2e-16 60.4 0.1 1.0 1 0 0 1 1 1 1 TCL1/MTCP1 family BRCC36_C PF18110.1 EMC78785.1 - 4.4e-31 106.9 2.1 8.1e-31 106.0 2.1 1.4 1 0 0 1 1 1 1 BRCC36 C-terminal helical domain JAB PF01398.21 EMC78785.1 - 1.4e-18 66.9 1.3 1.4e-18 66.9 1.3 1.8 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 EMC78785.1 - 0.0032 17.2 0.4 0.0032 17.2 0.4 1.7 1 1 0 1 1 1 1 Prokaryotic homologs of the JAB domain bZIP_2 PF07716.15 EMC78785.1 - 0.62 10.2 8.8 0.99 9.5 8.8 1.3 1 0 0 1 1 1 0 Basic region leucine zipper SprT-like PF10263.9 EMC78786.1 - 3e-16 59.3 0.0 4.8e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 SprT-like family Aspzincin_M35 PF14521.6 EMC78786.1 - 0.11 13.0 0.1 0.46 11.0 0.1 2.0 2 1 0 2 2 2 0 Lysine-specific metallo-endopeptidase Glyco_transf_41 PF13844.6 EMC78787.1 - 6.9e-257 852.4 0.0 8.9e-257 852.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 41 TPR_1 PF00515.28 EMC78787.1 - 8e-98 316.7 27.2 2.6e-10 39.7 0.3 13.5 13 0 0 13 13 13 11 Tetratricopeptide repeat TPR_11 PF13414.6 EMC78787.1 - 3.8e-90 295.3 36.3 9.2e-11 41.2 0.4 12.8 3 2 10 13 13 13 12 TPR repeat TPR_2 PF07719.17 EMC78787.1 - 5.7e-74 238.4 27.9 2.5e-08 33.4 0.4 13.2 13 0 0 13 13 12 11 Tetratricopeptide repeat TPR_17 PF13431.6 EMC78787.1 - 3.6e-68 221.2 28.8 2e-05 24.7 0.1 13.7 13 0 0 13 13 13 12 Tetratricopeptide repeat TPR_8 PF13181.6 EMC78787.1 - 1.3e-66 215.3 12.5 1.1e-06 28.4 0.1 13.5 14 0 0 14 14 13 11 Tetratricopeptide repeat TPR_12 PF13424.6 EMC78787.1 - 2.6e-48 162.2 28.8 2.9e-10 40.3 0.2 9.5 6 2 3 9 9 9 6 Tetratricopeptide repeat TPR_14 PF13428.6 EMC78787.1 - 1.4e-46 153.1 16.9 0.00034 21.2 0.1 12.2 5 3 7 12 12 12 10 Tetratricopeptide repeat TPR_16 PF13432.6 EMC78787.1 - 1.7e-45 153.4 17.4 2.1e-09 37.9 0.1 7.6 6 1 0 7 7 7 6 Tetratricopeptide repeat TPR_19 PF14559.6 EMC78787.1 - 1.5e-43 147.2 20.5 2.1e-07 31.4 0.6 9.2 4 4 5 9 9 9 9 Tetratricopeptide repeat TPR_7 PF13176.6 EMC78787.1 - 2.2e-39 130.6 17.0 9.8e-05 22.1 0.1 13.0 13 1 1 14 14 13 9 Tetratricopeptide repeat TPR_10 PF13374.6 EMC78787.1 - 6.1e-36 121.3 47.3 7e-07 28.9 0.4 12.2 12 0 0 12 12 12 8 Tetratricopeptide repeat TPR_9 PF13371.6 EMC78787.1 - 1.1e-17 64.0 14.7 0.0008 19.5 0.4 6.9 5 1 1 7 7 6 5 Tetratricopeptide repeat TPR_6 PF13174.6 EMC78787.1 - 1.6e-15 56.6 14.2 0.47 11.2 0.0 10.5 11 0 0 11 11 9 2 Tetratricopeptide repeat NARP1 PF12569.8 EMC78787.1 - 1.3e-14 54.1 4.7 0.0015 17.5 0.0 5.7 1 1 3 5 5 5 3 NMDA receptor-regulated protein 1 TPR_4 PF07721.14 EMC78787.1 - 6.2e-14 51.1 10.0 1.5 9.7 0.2 9.3 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EMC78787.1 - 4e-12 46.1 13.5 0.00031 20.2 0.1 4.8 1 1 1 4 4 4 3 MalT-like TPR region TPR_15 PF13429.6 EMC78787.1 - 4.4e-10 39.2 8.6 5.1e-06 25.9 1.0 4.9 1 1 3 5 5 5 2 Tetratricopeptide repeat FAT PF02259.23 EMC78787.1 - 5.7e-08 32.3 0.1 0.69 9.1 0.0 5.7 2 2 1 4 4 4 3 FAT domain MIT PF04212.18 EMC78787.1 - 3.7e-07 30.1 21.4 0.11 12.6 0.1 8.5 7 1 2 9 9 8 2 MIT (microtubule interacting and transport) domain TPR_3 PF07720.12 EMC78787.1 - 2.9e-06 27.2 1.5 1.2 9.2 0.0 5.7 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_21 PF09976.9 EMC78787.1 - 4.7e-06 26.4 10.4 0.13 11.9 0.0 5.2 3 2 2 5 5 5 3 Tetratricopeptide repeat-like domain Wzy_C_2 PF11846.8 EMC78787.1 - 8.2e-05 22.6 12.3 0.0085 16.0 0.2 4.6 5 0 0 5 5 4 1 Virulence factor membrane-bound polymerase, C-terminal SNAP PF14938.6 EMC78787.1 - 0.00019 21.0 15.1 0.034 13.6 2.4 4.7 1 1 2 4 4 4 2 Soluble NSF attachment protein, SNAP EST1_DNA_bind PF10373.9 EMC78787.1 - 0.00019 21.0 14.0 0.23 10.9 0.1 4.8 5 1 1 6 6 6 2 Est1 DNA/RNA binding domain SHNi-TPR PF10516.9 EMC78787.1 - 0.0016 17.9 2.5 12 5.4 0.0 5.5 7 0 0 7 7 6 0 SHNi-TPR BTAD PF03704.17 EMC78787.1 - 0.002 18.6 17.2 0.33 11.4 0.7 5.8 3 2 2 5 5 5 1 Bacterial transcriptional activator domain ANAPC3 PF12895.7 EMC78787.1 - 0.013 15.7 16.7 0.057 13.6 0.9 5.5 3 2 2 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TOM20_plant PF06552.12 EMC78787.1 - 0.048 13.4 0.3 31 4.3 0.0 4.0 3 2 1 4 4 4 0 Plant specific mitochondrial import receptor subunit TOM20 RPN7 PF10602.9 EMC78787.1 - 0.06 13.0 9.0 29 4.3 0.1 6.4 5 2 5 10 10 9 0 26S proteasome subunit RPN7 Fis1_TPR_C PF14853.6 EMC78787.1 - 0.072 13.2 0.5 1 9.5 0.0 3.3 3 0 0 3 3 2 0 Fis1 C-terminal tetratricopeptide repeat Tcf25 PF04910.14 EMC78787.1 - 0.082 12.0 0.1 0.22 10.6 0.0 1.7 2 0 0 2 2 2 0 Transcriptional repressor TCF25 Mad3_BUB1_I PF08311.12 EMC78787.1 - 0.1 12.6 8.2 92 3.0 0.1 6.8 6 1 1 8 8 8 0 Mad3/BUB1 homology region 1 Alkyl_sulf_dimr PF14863.6 EMC78787.1 - 0.18 12.2 2.2 12 6.3 0.1 3.3 3 0 0 3 3 2 0 Alkyl sulfatase dimerisation DUF627 PF04781.12 EMC78787.1 - 0.21 11.6 4.0 7.3 6.6 0.0 4.5 3 1 2 5 5 4 0 Protein of unknown function (DUF627) TPR_20 PF14561.6 EMC78787.1 - 0.4 11.0 13.2 1.9 8.9 0.2 5.9 4 2 3 7 7 7 0 Tetratricopeptide repeat DUF5113 PF17140.4 EMC78787.1 - 1.8 8.3 11.3 31 4.3 0.2 5.4 3 2 4 7 7 7 0 Domain of unknown function (DUF5113) DUF3591 PF12157.8 EMC78788.1 - 1.6e-163 544.5 0.6 5.8e-163 542.6 0.0 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF3591) Bromodomain PF00439.25 EMC78788.1 - 7.2e-45 151.0 3.9 4.7e-23 81.1 0.8 2.8 2 0 0 2 2 2 2 Bromodomain zf-CCHC_6 PF15288.6 EMC78788.1 - 4.1e-16 58.5 0.4 1.3e-15 56.9 0.4 1.9 1 0 0 1 1 1 1 Zinc knuckle TBP-binding PF09247.11 EMC78788.1 - 0.0004 20.6 0.2 0.0011 19.2 0.2 1.8 1 0 0 1 1 1 1 TATA box-binding protein binding Ras PF00071.22 EMC78789.1 - 1.1e-55 187.7 0.0 1.3e-55 187.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC78789.1 - 3.1e-23 82.3 0.0 4.3e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC78789.1 - 1.4e-09 37.6 0.0 2.1e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC78789.1 - 0.0088 15.6 0.0 0.043 13.4 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 EMC78789.1 - 0.098 12.2 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Gtr1_RagA PF04670.12 EMC78789.1 - 0.21 10.9 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region CHORD PF04968.12 EMC78790.1 - 1.1e-53 179.8 20.2 2.5e-28 98.5 5.9 2.7 3 0 0 3 3 3 2 CHORD CS PF04969.16 EMC78790.1 - 1.4e-12 48.4 0.4 2.5e-12 47.6 0.4 1.4 1 0 0 1 1 1 1 CS domain zf-tcix PF14952.6 EMC78790.1 - 0.028 14.0 3.4 1.5 8.5 1.0 2.7 2 0 0 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding BTK PF00779.19 EMC78790.1 - 1.6 8.6 16.5 0.6 10.0 0.5 3.6 4 1 0 4 4 4 0 BTK motif Connexin PF00029.19 EMC78791.1 - 3.6e-95 318.2 0.1 4.5e-95 317.9 0.1 1.1 1 0 0 1 1 1 1 Connexin Connexin PF00029.19 EMC78792.1 - 6e-84 281.5 17.1 2.4e-82 276.2 17.1 2.1 1 1 0 1 1 1 1 Connexin COesterase PF00135.28 EMC78793.1 - 6.4e-190 632.4 0.0 7.6e-190 632.1 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMC78793.1 - 4.9e-05 23.3 0.2 0.00034 20.5 0.2 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Med12-LCEWAV PF12145.8 EMC78794.1 - 2.8e-186 620.0 0.6 1.3e-185 617.8 0.0 2.3 2 0 0 2 2 2 1 Eukaryotic Mediator 12 subunit domain Med12-PQL PF12144.8 EMC78794.1 - 3.4e-88 295.0 33.7 3.4e-88 295.0 33.7 3.9 2 1 0 3 3 3 1 Eukaryotic Mediator 12 catenin-binding domain Med12 PF09497.10 EMC78794.1 - 8.6e-15 54.8 0.0 2.1e-14 53.6 0.0 1.6 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 FANCI_S2 PF14676.6 EMC78794.1 - 0.052 13.9 0.2 0.27 11.6 0.2 2.3 1 0 0 1 1 1 0 FANCI solenoid 2 SET PF00856.28 EMC78794.1 - 0.28 11.6 3.2 0.42 11.0 0.1 2.6 1 1 0 2 2 2 0 SET domain PA26 PF04636.13 EMC78795.1 - 2.5e-181 603.4 0.0 2.8e-181 603.2 0.0 1.0 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) CMD PF02627.20 EMC78795.1 - 0.0037 17.3 0.0 0.0099 15.9 0.0 1.7 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family Leptin PF02024.15 EMC78795.1 - 0.012 15.4 0.0 0.21 11.4 0.0 2.3 2 0 0 2 2 2 0 Leptin FOXO-TAD PF16676.5 EMC78796.1 - 3.5e-21 75.3 6.8 6.1e-21 74.6 6.8 1.4 1 0 0 1 1 1 1 Transactivation domain of FOXO protein family FOXO_KIX_bdg PF16675.5 EMC78796.1 - 2.6e-07 30.9 0.3 2.6e-07 30.9 0.3 2.5 3 0 0 3 3 3 1 KIX-binding domain of forkhead box O, CR2 PX PF00787.24 EMC78797.1 - 4.3e-27 94.3 0.1 5e-27 94.1 0.1 1.0 1 0 0 1 1 1 1 PX domain HrpB7 PF09486.10 EMC78798.1 - 0.0049 17.3 0.3 0.0053 17.2 0.3 1.1 1 0 0 1 1 1 1 Bacterial type III secretion protein (HrpB7) HIP1_clath_bdg PF16515.5 EMC78798.1 - 0.005 17.4 1.0 0.0072 16.9 1.0 1.1 1 0 0 1 1 1 1 Clathrin-binding domain of Huntingtin-interacting protein 1 WEMBL PF05701.11 EMC78798.1 - 0.0063 15.3 0.0 0.0063 15.3 0.0 1.0 1 0 0 1 1 1 1 Weak chloroplast movement under blue light HAP1_N PF04849.13 EMC78798.1 - 0.0076 15.5 0.6 0.0094 15.2 0.6 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region ADIP PF11559.8 EMC78798.1 - 0.05 13.7 2.0 0.062 13.4 2.0 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding ImcF-related_N PF14331.6 EMC78798.1 - 0.097 12.0 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 ImcF-related N-terminal domain Spc7 PF08317.11 EMC78798.1 - 0.1 11.5 1.0 0.12 11.2 1.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein AA_permease_2 PF13520.6 EMC78799.1 - 1.8e-49 168.8 25.9 1.8e-49 168.8 25.9 2.1 1 1 1 2 2 2 2 Amino acid permease AA_permease PF00324.21 EMC78799.1 - 1.4e-34 119.5 26.7 1.4e-34 119.5 26.7 2.2 2 0 0 2 2 2 1 Amino acid permease AA_permease_C PF13906.6 EMC78799.1 - 3.4e-22 78.2 8.0 3.4e-22 78.2 8.0 4.1 4 0 0 4 4 4 1 C-terminus of AA_permease RRM_1 PF00076.22 EMC78800.1 - 1.5e-18 66.4 0.0 1.9e-18 66.1 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMC78800.1 - 0.035 13.9 0.0 0.093 12.6 0.0 1.6 1 1 0 1 1 1 0 Occluded RNA-recognition motif RRM_5 PF13893.6 EMC78800.1 - 0.15 11.6 0.0 0.19 11.3 0.0 1.1 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPO22 PF08631.10 EMC78801.1 - 5.8e-81 272.0 24.1 1.6e-77 260.7 2.8 3.2 3 0 0 3 3 3 2 Meiosis protein SPO22/ZIP4 like TPR_2 PF07719.17 EMC78801.1 - 1.7e-06 27.7 7.5 0.052 13.7 0.1 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EMC78801.1 - 8.9e-06 25.9 4.5 0.34 11.2 0.0 5.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMC78801.1 - 6.8e-05 22.5 4.1 0.28 11.1 0.2 5.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EMC78801.1 - 0.00026 21.4 1.1 0.051 14.1 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EMC78801.1 - 0.035 14.3 0.3 2.9 8.3 0.1 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat ptaRNA1_toxin PF12703.7 EMC78801.1 - 0.046 13.8 0.1 0.12 12.5 0.1 1.7 1 0 0 1 1 1 0 Toxin of toxin-antitoxin type 1 system DUF493 PF04359.14 EMC78801.1 - 0.079 13.5 0.4 0.36 11.4 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF493) NRBF2_MIT PF17169.4 EMC78801.1 - 0.17 12.2 2.5 12 6.2 0.0 4.4 5 0 0 5 5 5 0 MIT domain of nuclear receptor-binding factor 2 Plk4_PB2 PF18409.1 EMC78801.1 - 0.18 12.5 6.1 1.1 10.0 0.4 3.7 3 1 1 4 4 4 0 Polo-like Kinase 4 Polo Box 2 GDPD PF03009.17 EMC78802.1 - 9.2e-21 74.7 0.0 4e-20 72.6 0.0 1.9 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family 7TMR-HDED PF07697.11 EMC78802.1 - 0.033 14.3 0.4 0.045 13.9 0.4 1.2 1 0 0 1 1 1 0 7TM-HD extracellular DUF1011 PF06237.12 EMC78802.1 - 3.2 8.2 8.1 0.16 12.3 0.5 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1011) 7tm_1 PF00001.21 EMC78803.1 - 2.1e-65 220.7 13.6 2.9e-65 220.2 13.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC78803.1 - 9.6e-13 48.1 14.4 2.6e-12 46.7 14.4 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC78803.1 - 8.3e-06 25.7 4.4 8.3e-06 25.7 4.4 2.3 2 1 0 3 3 3 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC78803.1 - 1.8e-05 24.5 12.6 1.8e-05 24.5 12.6 2.2 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Pox_P21 PF05313.12 EMC78803.1 - 0.051 13.1 0.7 0.051 13.1 0.7 3.0 3 0 0 3 3 3 0 Poxvirus P21 membrane protein RseC_MucC PF04246.12 EMC78803.1 - 5.6 6.9 8.0 0.21 11.5 0.3 2.4 3 0 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC fn3 PF00041.21 EMC78804.1 - 5.3e-05 23.5 0.2 8e-05 22.9 0.2 1.3 1 0 0 1 1 1 1 Fibronectin type III domain IL6Ra-bind PF09240.10 EMC78804.1 - 0.00017 22.0 0.4 0.00067 20.0 0.0 2.1 2 1 0 2 2 2 1 Interleukin-6 receptor alpha chain, binding LRR_8 PF13855.6 EMC78805.1 - 3.3e-17 62.0 7.5 2.9e-10 39.7 1.5 3.4 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EMC78805.1 - 1.8e-10 40.9 11.9 0.0019 18.5 0.0 4.3 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) CH PF00307.31 EMC78805.1 - 3.7e-10 39.9 0.0 7.7e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain LRR_1 PF00560.33 EMC78805.1 - 0.0023 18.2 10.7 14 6.7 1.2 6.3 5 1 0 5 5 5 1 Leucine Rich Repeat CDC24 PF06395.11 EMC78805.1 - 0.0082 16.4 0.0 0.021 15.0 0.0 1.8 1 0 0 1 1 1 1 CDC24 Calponin LRR_6 PF13516.6 EMC78805.1 - 0.029 14.4 13.2 14 6.1 0.4 5.3 5 0 0 5 5 5 0 Leucine Rich repeat CAMSAP_CH PF11971.8 EMC78805.1 - 0.045 13.6 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 CAMSAP CH domain FYTT PF07078.11 EMC78806.1 - 8.9e-05 22.0 5.5 0.0001 21.8 5.5 1.0 1 0 0 1 1 1 1 Forty-two-three protein CH PF00307.31 EMC78807.1 - 3.2e-92 304.0 2.1 1.3e-25 89.7 0.1 4.3 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.6 EMC78807.1 - 3.9e-12 46.4 0.7 1.3e-11 44.8 0.2 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EMC78807.1 - 3.2e-11 41.9 3.0 4.2e-05 22.8 0.5 3.1 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EMC78807.1 - 8.7e-07 28.4 0.9 0.037 14.0 0.1 3.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EMC78807.1 - 2.3e-06 26.8 10.6 0.00072 18.9 0.1 4.8 4 1 1 5 5 5 2 EF hand CAMSAP_CH PF11971.8 EMC78807.1 - 8.4e-06 25.5 0.1 0.00037 20.3 0.0 2.8 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_8 PF13833.6 EMC78807.1 - 0.017 15.0 1.2 0.2 11.5 0.1 3.1 2 1 0 2 2 2 0 EF-hand domain pair DUF5580 PF17743.1 EMC78807.1 - 0.024 13.2 0.0 0.032 12.8 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) SPARC_Ca_bdg PF10591.9 EMC78807.1 - 0.1 12.9 0.1 0.26 11.6 0.1 1.7 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region LRR_8 PF13855.6 EMC78808.1 - 1.3e-37 127.4 42.9 6.5e-14 51.4 5.0 4.8 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EMC78808.1 - 2.6e-21 75.3 42.0 1.1e-05 25.7 0.8 6.3 1 1 6 7 7 7 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC78808.1 - 9e-14 51.5 1.6 1.9e-07 31.1 0.0 2.7 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC78808.1 - 9.5e-08 31.7 11.2 3.9e-05 23.2 1.0 3.1 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 EMC78808.1 - 8.3e-07 28.7 44.9 1 10.2 2.1 9.8 10 0 0 10 10 10 3 Leucine Rich Repeat LRRNT PF01462.18 EMC78808.1 - 0.083 12.6 3.4 0.08 12.6 1.2 2.2 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 EMC78808.1 - 7.9 6.8 43.5 1.9 8.8 0.2 8.6 9 0 0 9 9 9 0 Leucine Rich repeat 7tm_1 PF00001.21 EMC78809.1 - 1.1e-60 205.2 17.7 1.4e-60 204.9 17.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC78809.1 - 1.9e-09 37.3 15.5 2.6e-09 36.9 15.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 EMC78809.1 - 4.2e-08 32.9 10.9 6.8e-08 32.2 10.9 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Piezo_RRas_bdg PF12166.8 EMC78809.1 - 0.035 13.4 0.2 0.06 12.6 0.2 1.4 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain DUF4059 PF13268.6 EMC78809.1 - 0.32 11.4 3.2 4 7.9 0.2 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4059) CYYR1 PF10873.8 EMC78809.1 - 2.2 8.7 8.4 1 9.8 1.0 2.5 1 1 1 2 2 2 0 Cysteine and tyrosine-rich protein 1 SNF PF00209.18 EMC78810.1 - 4.3e-197 655.9 41.6 5.4e-197 655.6 41.6 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family DUF1075 PF06388.11 EMC78811.1 - 6.9e-37 126.2 0.1 8.9e-37 125.8 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1075) DUF4389 PF14333.6 EMC78811.1 - 0.015 15.2 0.1 5.5 7.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4389) NB PF04159.13 EMC78811.1 - 0.073 13.1 0.1 0.1 12.6 0.1 1.2 1 0 0 1 1 1 0 NB glycoprotein DUF4044 PF13253.6 EMC78811.1 - 1.4 8.5 4.0 4.3 6.9 3.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4044) Kelch_1 PF01344.25 EMC78812.1 - 2.5e-56 187.0 8.5 1.1e-10 40.9 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EMC78812.1 - 1e-35 120.9 6.5 9.3e-08 32.1 0.0 7.1 1 1 5 6 6 6 6 Kelch motif BACK PF07707.15 EMC78812.1 - 4.9e-27 94.0 0.0 1.1e-26 92.9 0.0 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.31 EMC78812.1 - 2.8e-24 85.5 0.2 1.1e-23 83.5 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 EMC78812.1 - 4.9e-24 83.3 5.3 3.5e-05 23.6 0.0 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 EMC78812.1 - 7.4e-24 83.5 3.7 3.1e-06 27.3 0.0 6.7 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.6 EMC78812.1 - 8.1e-18 64.2 0.9 0.0014 18.6 0.0 5.6 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC78812.1 - 7e-11 41.9 13.0 0.0049 16.8 0.6 5.7 5 0 0 5 5 5 4 Kelch motif PQQ_3 PF13570.6 EMC78812.1 - 0.00044 20.6 1.8 8.9 6.9 0.0 4.7 5 0 0 5 5 5 1 PQQ-like domain WD40 PF00400.32 EMC78813.1 - 2.8e-22 78.6 3.8 7e-05 23.5 0.1 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC78813.1 - 0.00041 20.6 0.0 0.61 10.4 0.0 4.0 1 1 3 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EMC78813.1 - 0.0056 16.7 0.1 1.5 8.8 0.0 3.8 2 2 3 5 5 5 1 Ciliary BBSome complex subunit 2, middle region DHR-2 PF06920.13 EMC78814.1 - 3e-205 682.9 9.2 3e-205 682.9 9.2 1.7 2 0 0 2 2 2 1 Dock homology region 2 DOCK-C2 PF14429.6 EMC78814.1 - 4.6e-56 189.7 0.1 6.7e-55 185.9 0.0 2.5 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.8 EMC78814.1 - 2.5e-42 143.8 2.1 4.3e-42 143.1 0.7 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3398) PH PF00169.29 EMC78814.1 - 1.6e-11 44.6 0.6 7.8e-11 42.4 0.6 2.3 1 0 0 1 1 1 1 PH domain DUF1667 PF07892.11 EMC78814.1 - 0.13 12.3 0.1 0.56 10.3 0.1 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1667) ApoLp-III PF07464.11 EMC78814.1 - 0.25 11.4 2.9 0.57 10.3 1.2 2.4 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) FAM184 PF15665.5 EMC78814.1 - 8.3 6.1 9.3 27 4.5 3.6 2.6 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B Il13Ra_Ig PF18001.1 EMC78815.1 - 2.8e-40 136.3 0.7 2.8e-40 136.3 0.7 2.5 3 0 0 3 3 3 1 Interleukin-13 receptor subunit alpha Ig-like domain IL6Ra-bind PF09240.10 EMC78815.1 - 8e-19 67.9 0.6 1.8e-18 66.7 0.2 1.9 2 0 0 2 2 2 1 Interleukin-6 receptor alpha chain, binding EpoR_lig-bind PF09067.10 EMC78815.1 - 6.3e-08 32.8 0.1 2.1e-07 31.1 0.1 1.9 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding fn3 PF00041.21 EMC78815.1 - 0.00047 20.4 0.5 9.2 6.7 0.0 3.6 3 1 0 3 3 3 2 Fibronectin type III domain Tissue_fac PF01108.17 EMC78815.1 - 0.00063 19.6 3.4 0.63 9.9 0.0 3.7 3 1 0 3 3 3 2 Tissue factor IL2RB_N1 PF18707.1 EMC78815.1 - 0.051 14.1 3.0 0.21 12.2 0.3 2.6 2 0 0 2 2 2 0 Interleukin-2 receptor subunit beta N-terminal domain 1 Pkinase PF00069.25 EMC78816.1 - 5.2e-72 242.4 0.0 8.8e-72 241.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC78816.1 - 9.4e-54 182.4 0.0 1.5e-53 181.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1241 PF06840.11 EMC78816.1 - 2.7e-06 27.1 0.2 6.8e-06 25.8 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Pkinase_fungal PF17667.1 EMC78816.1 - 2.2e-05 23.4 1.4 7.7e-05 21.6 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EMC78816.1 - 0.0067 15.8 0.1 0.071 12.4 0.0 2.5 2 1 0 2 2 2 1 Kinase-like DEK_C PF08766.11 EMC78816.1 - 0.029 14.3 0.8 0.7 9.9 0.0 3.3 4 0 0 4 4 4 0 DEK C terminal domain APH PF01636.23 EMC78816.1 - 0.079 12.9 0.0 9.8 6.0 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EMC78816.1 - 0.097 12.0 0.5 0.27 10.6 0.0 2.0 3 0 0 3 3 3 0 Lipopolysaccharide kinase (Kdo/WaaP) family Stathmin PF00836.19 EMC78816.1 - 0.13 12.2 3.2 7 6.6 0.1 2.5 2 0 0 2 2 2 0 Stathmin family DUF5089 PF17002.5 EMC78816.1 - 0.46 10.3 11.6 0.1 12.5 7.7 1.9 3 0 0 3 3 3 0 Domain of unknown function (DUF5089) FERM_C PF09380.10 EMC78818.1 - 1.2e-25 89.7 0.3 2.4e-25 88.7 0.3 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 EMC78818.1 - 1.5e-14 54.4 0.1 2.7e-14 53.6 0.1 1.5 1 0 0 1 1 1 1 FERM central domain FA PF08736.11 EMC78818.1 - 4e-13 49.2 2.6 1.1e-12 47.8 0.9 2.3 2 0 0 2 2 2 1 FERM adjacent (FA) FERM_N PF09379.10 EMC78818.1 - 4.1e-09 36.3 0.0 9.6e-09 35.1 0.0 1.7 1 0 0 1 1 1 1 FERM N-terminal domain Ras PF00071.22 EMC78819.1 - 4.9e-56 188.8 0.3 2.6e-41 140.9 0.0 2.0 1 1 1 2 2 2 2 Ras family Roc PF08477.13 EMC78819.1 - 2.4e-18 66.5 0.0 1.6e-17 63.9 0.0 1.9 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC78819.1 - 1.1e-07 31.5 0.0 1.6e-06 27.7 0.0 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EMC78819.1 - 8.3e-07 29.0 0.1 0.0017 18.3 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EMC78819.1 - 1.6e-06 27.8 0.0 3.2e-06 26.8 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EMC78819.1 - 3.8e-05 23.7 0.0 5.5e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EMC78819.1 - 0.0042 16.6 0.1 0.025 14.1 0.0 2.3 2 1 0 2 2 2 1 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.5 EMC78819.1 - 0.02 14.9 0.0 0.034 14.2 0.0 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain TPP_enzyme_M PF00205.22 EMC78819.1 - 0.031 14.0 0.0 0.065 13.0 0.0 1.6 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain AAA_24 PF13479.6 EMC78819.1 - 0.099 12.4 0.1 0.37 10.5 0.0 1.8 1 1 0 2 2 2 0 AAA domain MeaB PF03308.16 EMC78819.1 - 0.13 11.2 0.1 2.1 7.3 0.0 2.1 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB zf-CCCH PF00642.24 EMC78821.1 - 1.7e-13 50.1 17.3 0.00021 21.1 0.4 4.6 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 EMC78821.1 - 7.1e-06 26.2 12.1 0.012 15.8 0.8 2.7 2 1 0 2 2 2 2 Zinc-finger containing family Torus PF16131.5 EMC78821.1 - 7.4e-06 26.6 18.9 0.021 15.5 0.2 4.3 2 2 2 4 4 4 4 Torus domain zf-CCCH_2 PF14608.6 EMC78821.1 - 1.1e-05 25.7 25.3 0.36 11.4 0.8 4.4 4 0 0 4 4 4 4 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 EMC78821.1 - 2.7e-05 23.8 2.1 2.7e-05 23.8 2.1 4.8 4 2 0 4 4 4 3 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EMC78821.1 - 0.00045 20.2 32.1 0.015 15.3 3.2 6.7 4 4 0 4 4 4 2 Zinc finger domain DUF1936 PF09151.10 EMC78821.1 - 0.34 10.9 3.8 8 6.5 0.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1936) Sulfotransfer_2 PF03567.14 EMC78822.1 - 1.4e-48 166.1 1.2 1.4e-48 166.1 1.2 1.6 2 0 0 2 2 2 1 Sulfotransferase family Phospholamban PF04272.14 EMC78822.1 - 0.15 11.5 0.1 0.38 10.2 0.1 1.7 1 0 0 1 1 1 0 Phospholamban Topoisom_I_N PF02919.15 EMC78822.1 - 0.17 11.4 4.7 0.26 10.8 4.7 1.3 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Sulfotransfer_2 PF03567.14 EMC78823.1 - 1.4e-18 67.7 0.2 1.6e-18 67.5 0.2 1.0 1 0 0 1 1 1 1 Sulfotransferase family Glypican PF01153.19 EMC78825.1 - 1.9e-221 736.7 5.2 2.4e-221 736.4 5.2 1.0 1 0 0 1 1 1 1 Glypican DUF5082 PF16888.5 EMC78825.1 - 0.0078 16.5 0.4 0.026 14.8 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF5082) DUF1910 PF08928.10 EMC78825.1 - 0.017 15.1 0.6 0.22 11.5 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1910) Fz PF01392.22 EMC78825.1 - 0.071 13.7 2.0 0.1 13.2 0.1 2.2 2 0 0 2 2 2 0 Fz domain Glypican PF01153.19 EMC78826.1 - 9.5e-155 516.6 1.2 1.2e-154 516.3 1.2 1.0 1 0 0 1 1 1 1 Glypican zf-HC5HC2H PF13771.6 EMC78828.1 - 1.6e-34 118.0 31.6 6.3e-18 64.8 9.4 3.6 4 0 0 4 4 4 2 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EMC78828.1 - 7.9e-14 51.8 29.3 3.7e-07 30.3 13.1 2.9 2 2 1 3 3 3 2 PHD-zinc-finger like domain zf-ANAPC11 PF12861.7 EMC78828.1 - 0.31 11.1 14.4 3.7 7.7 0.5 3.5 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger Pribosyltran PF00156.27 EMC78829.1 - 2.9e-23 82.2 0.0 3.5e-23 81.9 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EMC78829.1 - 0.02 14.3 0.0 0.025 14.0 0.0 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 EMC78829.1 - 0.17 11.3 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase Motile_Sperm PF00635.26 EMC78832.1 - 4.8e-18 65.0 0.2 7.8e-18 64.3 0.1 1.4 1 1 0 1 1 1 1 MSP (Major sperm protein) domain MMgT PF10270.9 EMC78833.1 - 1.3e-06 28.6 0.0 1.9e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Membrane magnesium transporter LIM PF00412.22 EMC78834.1 - 2e-33 114.4 57.2 6e-12 45.6 5.3 5.3 3 1 2 5 5 5 5 LIM domain Sgf11 PF08209.11 EMC78834.1 - 0.13 11.8 0.3 0.13 11.8 0.3 6.8 6 1 1 7 7 7 0 Sgf11 (transcriptional regulation protein) MAP7 PF05672.11 EMC78835.1 - 1.8e-12 47.3 15.5 1.8e-12 47.3 15.5 3.4 2 1 1 3 3 3 1 MAP7 (E-MAP-115) family DUF5401 PF17380.2 EMC78835.1 - 0.29 9.2 42.2 0.022 12.9 30.8 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5401) DUF87 PF01935.17 EMC78835.1 - 2.3 8.3 5.9 5.3 7.1 5.9 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain ARGLU PF15346.6 EMC78835.1 - 2.3 8.1 55.0 0.39 10.6 36.1 2.5 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 Pentaxin PF00354.17 EMC78836.1 - 1.6e-10 41.0 0.7 3.1e-08 33.6 0.7 2.0 1 1 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.6 EMC78836.1 - 4.1e-07 30.3 0.0 5.4e-06 26.6 0.0 2.0 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily 7tm_2 PF00002.24 EMC78837.1 - 4e-48 163.9 23.9 5.4e-48 163.4 23.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 EMC78837.1 - 6.5e-16 58.6 4.7 1.2e-15 57.7 4.7 1.5 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif 7tm_1 PF00001.21 EMC78838.1 - 3.9e-58 196.8 14.9 6.3e-58 196.2 14.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC78838.1 - 2.5e-11 43.5 14.4 3.9e-11 42.8 14.4 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 EMC78838.1 - 1.2e-08 34.6 14.8 1.6e-08 34.2 14.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 EMC78838.1 - 1.8e-06 27.8 11.0 1.8e-06 27.8 11.0 1.9 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx TAS2R PF05296.13 EMC78838.1 - 0.00055 19.1 4.0 0.00055 19.1 4.0 2.0 2 0 0 2 2 2 1 Taste receptor protein (TAS2R) Gaa1 PF04114.14 EMC78838.1 - 3.1 6.7 9.7 0.25 10.3 1.3 2.0 2 0 0 2 2 2 0 Gaa1-like, GPI transamidase component Vg_Tdu PF07545.14 EMC78839.1 - 5.4e-20 70.8 0.2 1.1e-19 69.9 0.2 1.5 1 0 0 1 1 1 1 Vestigial/Tondu family TNF PF00229.18 EMC78840.1 - 8.1e-32 109.8 0.3 1.2e-31 109.3 0.3 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.21 EMC78840.1 - 0.0015 18.7 0.8 0.0053 17.0 0.4 2.1 2 1 0 2 2 2 1 C1q domain DUF2244 PF10003.9 EMC78840.1 - 0.19 11.4 0.0 0.49 10.0 0.0 1.6 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) RhoGEF67_u2 PF16614.5 EMC78841.1 - 1.7e-62 208.2 1.9 1.7e-62 208.2 1.9 2.4 2 0 0 2 2 2 1 Unstructured region two on RhoGEF 6 and 7 betaPIX_CC PF16523.5 EMC78841.1 - 1e-37 127.8 8.4 1e-37 127.8 8.4 3.4 4 0 0 4 4 4 1 betaPIX coiled coil RhoGEF PF00621.20 EMC78841.1 - 5.2e-33 114.8 1.3 5.2e-33 114.8 1.3 2.3 2 0 0 2 2 2 1 RhoGEF domain SH3_9 PF14604.6 EMC78841.1 - 1.8e-17 62.9 0.1 4.3e-17 61.7 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC78841.1 - 2.6e-16 59.0 0.4 5.2e-16 58.1 0.4 1.5 1 0 0 1 1 1 1 Variant SH3 domain CH PF00307.31 EMC78841.1 - 3.2e-16 59.5 0.0 8.7e-16 58.1 0.0 1.8 1 0 0 1 1 1 1 Calponin homology (CH) domain SH3_1 PF00018.28 EMC78841.1 - 1.6e-14 53.2 0.3 3.1e-14 52.3 0.3 1.5 1 0 0 1 1 1 1 SH3 domain PH PF00169.29 EMC78841.1 - 1.1e-09 38.7 0.0 3e-09 37.3 0.0 1.7 1 0 0 1 1 1 1 PH domain RhoGEF67_u1 PF16615.5 EMC78841.1 - 3.6e-09 37.0 5.8 3.6e-09 37.0 5.8 2.3 2 0 0 2 2 2 1 Unstructured region one on RhoGEF 6 and 7 CAMSAP_CH PF11971.8 EMC78841.1 - 0.0027 17.5 0.0 0.0084 15.9 0.0 1.8 1 0 0 1 1 1 1 CAMSAP CH domain Nmad5 PF18757.1 EMC78841.1 - 0.14 12.4 2.6 0.41 10.8 0.9 2.4 2 0 0 2 2 2 0 Nucleotide modification associated domain 5 CENP-Q PF13094.6 EMC78841.1 - 0.27 11.4 15.0 0.038 14.2 5.1 3.3 3 0 0 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit ZapB PF06005.12 EMC78841.1 - 1.1 9.8 16.0 0.12 12.8 5.9 3.5 3 1 0 3 3 3 0 Cell division protein ZapB RPW8 PF05659.11 EMC78841.1 - 1.1 8.9 11.0 1 9.0 0.4 2.9 3 0 0 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 SKA1 PF07160.12 EMC78841.1 - 1.6 8.5 10.9 0.15 11.9 3.2 2.8 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 1 Nsp1_C PF05064.13 EMC78841.1 - 4 7.3 10.8 0.3 10.9 1.9 3.3 4 0 0 4 4 4 0 Nsp1-like C-terminal region YabA PF06156.13 EMC78841.1 - 7.9 7.2 10.5 2.3 8.9 2.2 3.3 3 0 0 3 3 3 0 Initiation control protein YabA RRM_1 PF00076.22 EMC78842.1 - 2.8e-23 81.5 0.1 4.1e-23 81.0 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM1CTR PF08081.11 EMC78842.1 - 3.4e-21 75.0 18.8 3.4e-21 75.0 18.8 9.7 6 3 2 8 8 8 1 RBM1CTR (NUC064) family RRM_7 PF16367.5 EMC78842.1 - 0.0093 16.1 0.0 0.018 15.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 EMC78842.1 - 0.01 15.5 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMC78842.1 - 0.048 13.5 0.0 0.072 13.0 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif PHM7_cyt PF14703.6 EMC78842.1 - 0.072 13.3 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter EMP70 PF02990.16 EMC78843.1 - 5.6e-216 718.2 12.9 5.6e-216 718.2 12.9 1.4 2 0 0 2 2 2 1 Endomembrane protein 70 zf-C2H2 PF00096.26 EMC78844.1 - 6.2e-21 73.6 31.2 1.3e-06 28.5 3.0 5.2 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC78844.1 - 2.8e-20 71.8 27.6 3.7e-07 30.3 0.3 4.7 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC78844.1 - 7.9e-13 48.1 25.6 0.00056 20.5 1.9 5.2 5 0 0 5 5 5 4 C2H2-type zinc finger zf_ZIC PF18366.1 EMC78844.1 - 1.7e-09 37.6 5.0 1.7e-09 37.6 5.0 4.1 4 2 1 5 5 5 1 Zic proteins zinc finger domain zf-met PF12874.7 EMC78844.1 - 2.9e-06 27.4 8.1 0.0001 22.6 1.0 3.5 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMC78844.1 - 6.9e-06 26.2 13.6 0.0025 18.1 0.2 4.9 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMC78844.1 - 9.9e-06 25.4 4.2 0.00046 20.1 1.8 3.1 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EMC78844.1 - 0.016 15.5 2.2 0.016 15.5 2.2 3.1 1 1 2 3 3 3 0 C2H2-type zinc ribbon Zf_RING PF16744.5 EMC78844.1 - 0.028 14.5 1.1 0.11 12.7 0.2 2.2 1 1 0 2 2 2 0 KIAA1045 RING finger MGC-24 PF05283.11 EMC78844.1 - 0.17 12.3 2.8 6.5 7.2 0.0 2.2 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin zf-C2H2_aberr PF17017.5 EMC78844.1 - 2.6 8.2 8.0 6.4 6.9 0.1 3.1 1 1 3 4 4 4 0 Aberrant zinc-finger FOXP-CC PF16159.5 EMC78844.1 - 5.6 7.7 13.1 13 6.5 0.0 4.4 2 2 3 5 5 5 0 FOXP coiled-coil domain zf-Di19 PF05605.12 EMC78844.1 - 5.7 7.3 20.7 14 6.1 2.0 3.7 1 1 3 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.5 EMC78844.1 - 8.6 6.2 7.2 0.61 9.9 0.8 2.4 3 0 0 3 3 3 0 zinc-finger C2H2-type FGF PF00167.18 EMC78845.1 - 1.2e-43 148.2 0.4 1.8e-43 147.6 0.4 1.3 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.13 EMC78845.1 - 0.00043 20.5 0.1 0.0031 17.7 0.0 2.0 1 1 1 2 2 2 1 Fascin domain TGF_beta_GS PF08515.12 EMC78845.1 - 0.14 11.6 0.5 0.28 10.7 0.5 1.5 1 0 0 1 1 1 0 Transforming growth factor beta type I GS-motif Trypsin PF00089.26 EMC78846.1 - 7.7e-65 218.8 1.1 1e-64 218.4 1.1 1.2 1 0 0 1 1 1 1 Trypsin Gla PF00594.20 EMC78846.1 - 1.7e-21 76.1 9.1 3.3e-21 75.2 9.1 1.5 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.6 EMC78846.1 - 9.1e-12 45.1 26.3 1.3e-11 44.6 6.8 2.9 3 0 0 3 3 3 2 Coagulation Factor Xa inhibitory site EGF PF00008.27 EMC78846.1 - 3.2e-08 33.7 16.8 5.2e-07 29.8 4.7 2.8 2 0 0 2 2 2 2 EGF-like domain cEGF PF12662.7 EMC78846.1 - 5.4e-08 32.6 5.3 0.00015 21.6 0.4 3.0 2 0 0 2 2 2 2 Complement Clr-like EGF-like hEGF PF12661.7 EMC78846.1 - 0.00035 21.1 13.2 0.0011 19.5 2.3 3.4 2 0 0 2 2 2 1 Human growth factor-like EGF Trypsin_2 PF13365.6 EMC78846.1 - 0.00053 20.9 0.0 0.0013 19.7 0.0 1.7 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 EMC78846.1 - 0.003 17.9 0.0 0.0064 16.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) EGF_3 PF12947.7 EMC78846.1 - 0.1 12.8 22.1 1.2 9.4 7.2 2.7 2 0 0 2 2 2 0 EGF domain EGF_CA PF07645.15 EMC78846.1 - 0.14 12.4 19.4 0.13 12.5 9.5 3.2 2 1 0 2 2 2 0 Calcium-binding EGF domain NUDE_C PF04880.13 EMC78847.1 - 2.6e-46 158.3 13.3 6e-46 157.1 0.7 2.4 2 1 0 2 2 2 1 NUDE protein, C-terminal conserved region PRKG1_interact PF15898.5 EMC78847.1 - 0.004 18.0 7.7 0.004 18.0 7.7 2.9 1 1 0 2 2 2 1 cGMP-dependent protein kinase interacting domain HALZ PF02183.18 EMC78847.1 - 0.019 15.1 2.6 0.019 15.1 2.6 3.2 3 0 0 3 3 3 0 Homeobox associated leucine zipper DUF5576 PF17739.1 EMC78847.1 - 0.025 14.7 0.3 2.5 8.2 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5576) Rootletin PF15035.6 EMC78847.1 - 0.068 13.2 31.9 0.15 12.0 12.3 2.3 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF1664 PF07889.12 EMC78847.1 - 0.091 12.8 9.6 0.053 13.6 4.5 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Golgin_A5 PF09787.9 EMC78847.1 - 0.13 11.7 24.2 0.23 10.9 24.2 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 ATG16 PF08614.11 EMC78847.1 - 0.19 11.9 35.6 1.3 9.2 9.0 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 EMC78847.1 - 0.24 11.5 35.0 0.064 13.3 9.9 3.4 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein HAD_SAK_1 PF10307.9 EMC78847.1 - 0.25 11.1 7.1 0.32 10.8 3.1 1.9 1 1 1 2 2 2 0 HAD domain family 1 in Swiss Army Knife RNA repair proteins KxDL PF10241.9 EMC78847.1 - 1.5 9.1 15.1 0.31 11.4 5.9 2.7 2 1 0 2 2 2 0 Uncharacterized conserved protein FlaC_arch PF05377.11 EMC78847.1 - 1.6 9.2 8.7 3.2 8.2 0.9 4.0 2 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Fzo_mitofusin PF04799.13 EMC78847.1 - 2.1 7.9 15.2 0.19 11.3 5.5 2.8 1 1 3 4 4 4 0 fzo-like conserved region BST2 PF16716.5 EMC78847.1 - 2.4 8.8 24.8 0.31 11.6 11.5 3.1 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 YabA PF06156.13 EMC78847.1 - 2.6 8.7 20.7 4.7 7.9 6.5 3.3 1 1 1 2 2 2 0 Initiation control protein YabA YtxH PF12732.7 EMC78847.1 - 4.5 7.9 5.9 4 8.0 0.4 3.0 2 1 1 3 3 3 0 YtxH-like protein DUF5595 PF18077.1 EMC78847.1 - 4.9 7.3 18.7 0.072 13.2 2.9 3.6 2 2 2 4 4 4 0 Domain of unknown function (DUF5595) Lectin_N PF03954.14 EMC78847.1 - 6 6.6 11.4 1.2 8.9 3.8 3.1 2 1 2 4 4 4 0 Hepatic lectin, N-terminal domain CENP-F_leu_zip PF10473.9 EMC78847.1 - 6.1 6.9 31.1 1.5 8.9 22.9 2.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ADIP PF11559.8 EMC78847.1 - 8.4 6.5 28.5 1.3 9.1 10.1 3.2 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Myosin_tail_1 PF01576.19 EMC78848.1 - 0 1685.6 320.9 0 1685.4 320.9 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.21 EMC78848.1 - 0 1016.2 0.4 0 1016.2 0.4 3.9 3 1 0 4 4 4 1 Myosin head (motor domain) Myosin_N PF02736.19 EMC78848.1 - 9.8e-13 47.7 0.2 2.7e-12 46.3 0.2 1.8 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain ADIP PF11559.8 EMC78848.1 - 2.7e-05 24.3 20.2 2.7e-05 24.3 20.2 14.3 1 1 12 14 14 14 4 Afadin- and alpha -actinin-Binding IQ PF00612.27 EMC78848.1 - 8.1e-05 22.1 0.1 0.00028 20.4 0.1 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif CC2-LZ PF16516.5 EMC78848.1 - 0.0052 17.1 18.6 0.0052 17.1 18.6 17.0 4 3 12 16 16 16 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator AAA_22 PF13401.6 EMC78848.1 - 0.045 14.0 0.0 0.045 14.0 0.0 6.6 5 2 1 7 7 7 0 AAA domain HEAT_UF PF18817.1 EMC78848.1 - 0.14 12.5 0.4 13 6.2 0.2 3.1 2 0 0 2 2 2 0 Repeat of uncharacterized protein PH0542 Mab-21 PF03281.14 EMC78849.1 - 7.6e-14 51.7 0.0 5.6e-13 48.8 0.0 2.0 1 1 0 1 1 1 1 Mab-21 protein zf-TRM13_CCCH PF11722.8 EMC78849.1 - 0.042 13.6 0.8 0.59 10.0 0.2 2.4 2 0 0 2 2 2 0 CCCH zinc finger in TRM13 protein Actin PF00022.19 EMC78850.1 - 9.9e-41 139.7 0.0 2.6e-40 138.3 0.0 1.5 1 1 0 1 1 1 1 Actin NYAP_N PF15439.6 EMC78851.1 - 1.3e-136 456.0 36.9 1.3e-136 456.0 36.9 3.8 2 2 1 3 3 3 1 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter NYAP_C PF15452.6 EMC78851.1 - 9.4e-41 140.4 13.7 9.4e-41 140.4 13.7 2.1 3 0 0 3 3 3 1 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter DHR-2 PF06920.13 EMC78852.1 - 2.6e-209 696.3 11.3 2.6e-209 696.3 11.3 2.3 3 0 0 3 3 3 1 Dock homology region 2 DOCK-C2 PF14429.6 EMC78852.1 - 2.7e-55 187.2 0.5 1.3e-54 185.0 0.3 2.4 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.8 EMC78852.1 - 1.5e-36 125.2 2.5 4.5e-36 123.7 2.5 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) PH PF00169.29 EMC78852.1 - 3.8e-13 49.8 0.6 2e-12 47.5 0.6 2.4 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 EMC78852.1 - 0.0078 16.6 1.2 0.04 14.3 0.1 2.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_10 PF15411.6 EMC78852.1 - 0.026 14.8 0.0 0.083 13.2 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain Cullin PF00888.22 EMC78853.1 - 2.2e-227 756.6 9.5 2.7e-227 756.3 9.5 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EMC78853.1 - 1.7e-27 95.2 1.1 1.7e-27 95.2 1.1 2.3 2 0 0 2 2 2 1 Cullin protein neddylation domain Phage_antitermQ PF06530.12 EMC78853.1 - 0.0087 16.0 0.2 0.05 13.5 0.1 2.4 2 0 0 2 2 2 1 Phage antitermination protein Q Phage_TAC_12 PF12363.8 EMC78853.1 - 0.055 13.9 0.8 1.1 9.7 0.0 3.3 3 0 0 3 3 3 0 Phage tail assembly chaperone protein, TAC RuvB_C PF05491.13 EMC78853.1 - 0.77 9.7 2.7 1e+02 2.9 0.0 4.4 4 0 0 4 4 4 0 RuvB C-terminal winged helix domain Glyco_hydro_4C PF11975.8 EMC78853.1 - 1.4 9.0 8.4 1.8 8.6 1.6 3.5 3 1 0 3 3 3 0 Family 4 glycosyl hydrolase C-terminal domain WAC_Acf1_DNA_bd PF10537.9 EMC78853.1 - 1.7 9.2 6.5 0.92 10.1 0.2 3.3 3 0 0 3 3 3 0 ATP-utilising chromatin assembly and remodelling N-terminal FAM124 PF15067.6 EMC78854.1 - 8e-106 352.9 0.5 9e-106 352.8 0.5 1.0 1 0 0 1 1 1 1 FAM124 family TPR_7 PF13176.6 EMC78854.1 - 0.14 12.3 0.1 0.5 10.5 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat Serpin PF00079.20 EMC78855.1 - 3.9e-109 365.4 0.0 4.4e-109 365.2 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Granin PF01271.17 EMC78856.1 - 9.9e-119 397.9 36.1 1.1e-118 397.7 36.1 1.0 1 0 0 1 1 1 1 Granin (chromogranin or secretogranin) IF2_N PF04760.15 EMC78856.1 - 0.005 16.6 1.4 1.6 8.6 0.2 3.3 2 0 0 2 2 2 2 Translation initiation factor IF-2, N-terminal region Telomere_Sde2_2 PF13297.6 EMC78856.1 - 0.08 12.6 0.1 0.26 11.0 0.1 1.9 1 0 0 1 1 1 0 Telomere stability C-terminal ISK_Channel PF02060.15 EMC78857.1 - 8.7e-10 38.4 0.1 1.1e-09 38.0 0.1 1.3 1 0 0 1 1 1 1 Slow voltage-gated potassium channel AMP-binding PF00501.28 EMC78858.1 - 2.9e-104 349.0 0.2 3.8e-104 348.6 0.2 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMC78858.1 - 4.4e-06 27.6 0.1 1.8e-05 25.6 0.1 2.1 2 1 0 2 2 2 1 AMP-binding enzyme C-terminal domain OCD_Mu_crystall PF02423.15 EMC78858.1 - 0.11 11.4 0.1 0.18 10.7 0.1 1.2 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family DAGAT PF03982.13 EMC78859.1 - 1.4e-119 398.5 0.2 1.6e-119 398.2 0.2 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase tRNA_synthFbeta PF17759.1 EMC78860.1 - 2.6e-51 174.1 0.0 3.6e-51 173.7 0.0 1.2 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain B3_4 PF03483.17 EMC78860.1 - 6.9e-28 97.5 0.1 1.4e-27 96.5 0.1 1.5 1 0 0 1 1 1 1 B3/4 domain PhetRS_B1 PF18262.1 EMC78860.1 - 1e-24 86.5 1.2 6e-24 84.1 0.6 2.5 2 1 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B5 PF03484.15 EMC78860.1 - 5.1e-16 58.7 0.0 7.3e-14 51.8 0.0 3.5 4 0 0 4 4 4 1 tRNA synthetase B5 domain Glyco_hydro_77 PF02446.17 EMC78860.1 - 0.25 10.1 0.0 0.36 9.6 0.0 1.1 1 0 0 1 1 1 0 4-alpha-glucanotransferase PAP2 PF01569.21 EMC78861.1 - 1.8e-16 60.1 3.3 1.8e-16 60.1 3.3 1.9 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EMC78861.1 - 4.7e-05 23.2 5.1 7e-05 22.6 4.2 1.8 1 1 0 1 1 1 1 PAP2 superfamily DUF212 PF02681.14 EMC78861.1 - 0.27 11.4 1.8 0.98 9.6 0.2 2.3 1 1 1 2 2 2 0 Divergent PAP2 family MNHE PF01899.16 EMC78861.1 - 4 7.2 11.3 8.6 6.1 0.1 3.5 2 1 2 4 4 4 0 Na+/H+ ion antiporter subunit REC114-like PF15165.6 EMC78862.1 - 1.6e-79 267.0 0.4 1.9e-79 266.8 0.4 1.0 1 0 0 1 1 1 1 Meiotic recombination protein REC114-like Ig_3 PF13927.6 EMC78863.1 - 6e-35 119.7 8.0 1.7e-11 44.5 0.0 3.5 4 0 0 4 4 4 3 Immunoglobulin domain I-set PF07679.16 EMC78863.1 - 2.7e-29 101.1 1.6 1.2e-11 44.5 0.1 3.9 3 1 1 4 4 4 3 Immunoglobulin I-set domain ig PF00047.25 EMC78863.1 - 6.5e-21 74.3 3.1 1.6e-08 34.6 0.0 3.5 3 1 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 EMC78863.1 - 3e-19 69.1 6.8 3.5e-05 24.0 0.3 4.0 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 EMC78863.1 - 1.2e-11 44.7 5.3 4.9e-06 26.7 0.0 4.8 3 3 1 4 4 4 2 Immunoglobulin V-set domain Ig_4 PF16680.5 EMC78863.1 - 7.5e-06 26.1 0.2 0.59 10.4 0.0 3.7 3 1 0 3 3 3 2 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 EMC78863.1 - 2.2e-05 23.9 0.0 2.7 7.6 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain Ig_5 PF16681.5 EMC78863.1 - 2.6e-05 24.5 0.1 0.84 10.1 0.0 3.8 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set PF05790.15 EMC78863.1 - 0.0023 18.1 0.0 0.27 11.4 0.0 3.1 3 0 0 3 3 3 1 Immunoglobulin C2-set domain Izumo-Ig PF16706.5 EMC78863.1 - 0.0059 16.6 0.0 14 5.9 0.0 3.3 3 0 0 3 3 3 2 Izumo-like Immunoglobulin domain ig PF00047.25 EMC78864.1 - 2.3e-14 53.3 0.0 7.2e-06 26.1 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 EMC78864.1 - 1e-12 48.5 0.0 1.3e-05 25.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 EMC78864.1 - 1e-09 38.6 0.1 5.2e-06 26.7 0.1 2.9 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC78864.1 - 1.2e-08 34.9 0.0 0.0027 17.7 0.0 3.0 2 1 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 EMC78864.1 - 1.5e-08 34.8 0.0 3.2e-07 30.5 0.0 2.6 2 1 0 2 2 2 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC78864.1 - 6.8e-07 29.3 0.2 6.7e-06 26.1 0.0 2.6 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 EMC78864.1 - 0.00011 22.5 0.0 0.0012 19.2 0.0 2.5 3 0 0 3 3 3 1 Immunoglobulin C1-set domain Marek_A PF02124.15 EMC78864.1 - 0.0058 16.5 0.3 0.0091 15.8 0.3 1.3 1 0 0 1 1 1 1 Marek's disease glycoprotein A Ig_6 PF18452.1 EMC78864.1 - 0.063 12.9 0.1 0.54 9.9 0.0 2.3 3 0 0 3 3 3 0 Immunoglobulin domain Cytadhesin_P30 PF07271.11 EMC78864.1 - 0.1 12.2 0.2 0.14 11.7 0.2 1.2 1 0 0 1 1 1 0 Cytadhesin P30/P32 Zona_pellucida PF00100.23 EMC78866.1 - 1.9e-44 152.4 0.0 2.3e-44 152.2 0.0 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain Zona_pellucida PF00100.23 EMC78867.1 - 4.5e-46 157.7 0.0 5.3e-46 157.5 0.0 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain DUF3583 PF12126.8 EMC78869.1 - 3.4e-25 89.2 17.1 4.3e-25 88.9 17.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3583) zf-B_box PF00643.24 EMC78869.1 - 4.5e-07 29.9 32.3 7.8e-05 22.7 13.7 4.1 3 2 0 3 3 3 2 B-box zinc finger zf-RING_5 PF14634.6 EMC78869.1 - 8.4e-05 22.5 8.4 8.4e-05 22.5 8.4 3.8 3 2 0 3 3 3 1 zinc-RING finger domain Myb_DNA-bind_3 PF12776.7 EMC78869.1 - 0.012 16.5 3.3 0.25 12.4 0.5 2.7 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain Exonuc_VII_L PF02601.15 EMC78869.1 - 0.22 11.1 5.8 0.27 10.7 5.8 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF5054 PF16477.5 EMC78869.1 - 0.34 10.7 5.3 0.43 10.3 4.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF5054) Spectrin PF00435.21 EMC78869.1 - 2.7 8.5 15.1 0.38 11.3 7.8 2.5 1 1 1 2 2 2 0 Spectrin repeat DUF4200 PF13863.6 EMC78869.1 - 4.4 7.7 19.3 7.5 7.0 18.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) OmpH PF03938.14 EMC78869.1 - 6.2 7.2 23.5 1.2 9.5 15.4 2.3 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) SCP2 PF02036.17 EMC78870.1 - 2.9e-16 59.8 0.0 2.5e-15 56.8 0.0 2.2 2 0 0 2 2 2 1 SCP-2 sterol transfer family Band_7 PF01145.25 EMC78870.1 - 5.5e-15 55.8 0.0 1.1e-14 54.9 0.0 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family Alkyl_sulf_C PF14864.6 EMC78870.1 - 0.083 13.2 0.0 0.29 11.4 0.0 1.8 2 0 0 2 2 2 0 Alkyl sulfatase C-terminal DUF3583 PF12126.8 EMC78871.1 - 4.3e-28 98.7 8.8 6.8e-28 98.1 8.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3583) zf-B_box PF00643.24 EMC78871.1 - 3.5e-05 23.9 2.4 3.5e-05 23.9 2.4 4.2 4 0 0 4 4 3 2 B-box zinc finger zf-RING_5 PF14634.6 EMC78871.1 - 0.0011 18.9 7.8 0.0011 18.9 7.8 4.4 4 0 0 4 4 3 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC78871.1 - 0.0021 17.9 8.0 0.0021 17.9 8.0 3.9 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 DUF4407 PF14362.6 EMC78871.1 - 0.25 10.7 5.7 0.48 9.7 5.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 EMC78871.1 - 0.55 9.8 8.3 0.92 9.0 8.3 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.9 EMC78871.1 - 0.98 8.4 13.7 1.6 7.7 13.7 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 C_Hendra PF16821.5 EMC78871.1 - 1.9 8.4 10.6 3.9 7.3 10.6 1.4 1 0 0 1 1 1 0 C protein from hendra and measles viruses Fmp27_WPPW PF10359.9 EMC78871.1 - 5.6 5.7 9.4 9.4 5.0 8.9 1.4 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Syntaxin-6_N PF09177.11 EMC78871.1 - 7.1 7.3 11.0 8 7.1 5.3 2.6 1 1 1 2 2 2 0 Syntaxin 6, N-terminal V_ATPase_I PF01496.19 EMC78871.1 - 7.8 4.3 7.8 11 3.7 7.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family LRR_8 PF13855.6 EMC78872.1 - 6.8e-24 83.4 9.9 5.2e-14 51.7 0.2 2.9 1 1 0 2 2 2 2 Leucine rich repeat I-set PF07679.16 EMC78872.1 - 3e-12 46.4 0.0 1.2e-11 44.5 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin I-set domain LRR_4 PF12799.7 EMC78872.1 - 3.8e-12 46.2 10.7 0.00062 20.1 1.7 3.8 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) Ig_3 PF13927.6 EMC78872.1 - 1.7e-11 44.6 0.0 5.2e-11 43.0 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC78872.1 - 3.8e-07 30.2 0.0 9.5e-07 28.9 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain LRR_5 PF13306.6 EMC78872.1 - 5.3e-07 29.7 1.0 0.093 12.7 0.0 2.8 2 1 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) V-set PF07686.17 EMC78872.1 - 1.4e-06 28.5 0.1 1.1e-05 25.6 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin V-set domain LRR_9 PF14580.6 EMC78872.1 - 2e-06 27.4 1.7 0.04 13.4 0.1 2.2 1 1 1 2 2 2 2 Leucine-rich repeat Ig_2 PF13895.6 EMC78872.1 - 1.6e-05 25.1 0.2 9.2e-05 22.7 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain TPKR_C2 PF16920.5 EMC78872.1 - 0.0045 17.1 1.1 0.014 15.6 1.1 1.8 1 0 0 1 1 1 1 Tyrosine-protein kinase receptor C2 Ig-like domain fn3 PF00041.21 EMC78872.1 - 0.026 14.9 0.0 0.083 13.2 0.0 1.9 1 0 0 1 1 1 0 Fibronectin type III domain LRR_6 PF13516.6 EMC78872.1 - 0.11 12.6 5.0 8.1 6.8 0.1 4.2 4 0 0 4 4 4 0 Leucine Rich repeat MAP17 PF15807.5 EMC78872.1 - 0.18 12.0 2.1 0.8 9.9 2.1 2.0 1 1 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 LRR_1 PF00560.33 EMC78872.1 - 0.19 12.4 9.5 12 6.9 0.1 5.9 7 1 0 7 7 4 0 Leucine Rich Repeat LRR_8 PF13855.6 EMC78873.1 - 3.6e-29 100.3 6.0 1.6e-13 50.2 4.2 2.3 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EMC78873.1 - 5.4e-12 45.7 13.5 2.3e-06 27.9 2.3 4.5 2 1 3 6 6 6 3 Leucine Rich repeats (2 copies) I-set PF07679.16 EMC78873.1 - 7.3e-12 45.2 0.0 1.3e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC78873.1 - 4.8e-11 43.1 0.4 1.1e-10 41.9 0.1 1.9 2 0 0 2 2 1 1 Immunoglobulin domain ig PF00047.25 EMC78873.1 - 3.8e-09 36.6 0.0 6.8e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.6 EMC78873.1 - 4.9e-08 32.7 0.2 1.9e-05 24.2 0.8 2.7 2 1 1 3 3 3 2 Leucine-rich repeat V-set PF07686.17 EMC78873.1 - 3.9e-07 30.2 0.0 8.8e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.6 EMC78873.1 - 1.3e-06 28.6 0.5 3.6e-06 27.2 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain LRR_1 PF00560.33 EMC78873.1 - 0.00029 21.0 6.3 3.6 8.5 0.3 5.1 4 1 0 4 4 4 2 Leucine Rich Repeat LRR_5 PF13306.6 EMC78873.1 - 0.00037 20.4 0.0 0.00075 19.5 0.0 1.5 1 1 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) TPKR_C2 PF16920.5 EMC78873.1 - 0.0045 17.1 0.4 0.0045 17.1 0.4 2.2 2 0 0 2 2 1 1 Tyrosine-protein kinase receptor C2 Ig-like domain LRR_6 PF13516.6 EMC78873.1 - 0.12 12.5 0.4 0.12 12.5 0.4 4.6 4 0 0 4 4 4 0 Leucine Rich repeat RBP_receptor PF14752.6 EMC78874.1 - 3.5e-235 782.3 16.7 4.2e-235 782.0 16.7 1.1 1 0 0 1 1 1 1 Retinol binding protein receptor p450 PF00067.22 EMC78876.1 - 4.2e-35 121.4 0.0 2.3e-28 99.1 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 Sema PF01403.19 EMC78877.1 - 1.8e-82 277.4 0.3 5.7e-82 275.8 0.0 1.8 2 0 0 2 2 2 1 Sema domain PSI PF01437.25 EMC78877.1 - 1.2e-05 25.8 4.2 1.2e-05 25.8 4.2 2.3 2 0 0 2 2 2 1 Plexin repeat Ig_2 PF13895.6 EMC78877.1 - 2.2e-05 24.7 2.3 4.2e-05 23.8 1.3 2.0 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 EMC78877.1 - 0.11 13.1 2.2 0.19 12.3 0.9 2.1 2 0 0 2 2 2 0 Immunoglobulin domain PID PF00640.23 EMC78881.1 - 2.5e-31 108.6 0.4 3.8e-31 108.0 0.4 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 EMC78881.1 - 1.1e-12 48.3 0.2 1.9e-12 47.5 0.2 1.4 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID_2 PF14719.6 EMC78881.1 - 9e-06 25.7 0.1 1.2e-05 25.3 0.1 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Ax_dynein_light PF10211.9 EMC78881.1 - 0.0019 18.1 0.4 0.0032 17.4 0.4 1.3 1 0 0 1 1 1 1 Axonemal dynein light chain TSC22 PF01166.18 EMC78881.1 - 0.0027 18.0 1.7 0.0081 16.5 1.7 1.8 1 0 0 1 1 1 1 TSC-22/dip/bun family DivIC PF04977.15 EMC78881.1 - 0.0041 16.9 4.7 0.0072 16.1 4.7 1.3 1 0 0 1 1 1 1 Septum formation initiator bZIP_2 PF07716.15 EMC78881.1 - 0.0075 16.3 4.7 0.0075 16.3 4.7 1.6 2 0 0 2 2 1 1 Basic region leucine zipper ZapB PF06005.12 EMC78881.1 - 0.01 16.3 2.1 0.02 15.3 2.1 1.4 1 0 0 1 1 1 0 Cell division protein ZapB bZIP_1 PF00170.21 EMC78881.1 - 0.012 15.7 2.0 0.022 14.9 2.0 1.4 1 0 0 1 1 1 0 bZIP transcription factor KASH_CCD PF14662.6 EMC78881.1 - 0.014 15.3 0.6 0.023 14.5 0.6 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Pox_A_type_inc PF04508.12 EMC78881.1 - 0.016 15.1 2.9 0.097 12.6 0.2 2.6 1 1 1 2 2 2 0 Viral A-type inclusion protein repeat HAP1_N PF04849.13 EMC78881.1 - 0.021 14.0 0.4 0.029 13.6 0.4 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region DUF4337 PF14235.6 EMC78881.1 - 0.022 14.9 0.0 0.037 14.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF2004 PF09406.10 EMC78881.1 - 0.024 15.0 0.2 0.088 13.1 0.0 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2004) Cnn_1N PF07989.11 EMC78881.1 - 0.025 14.7 0.6 0.052 13.7 0.6 1.5 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 Spc24 PF08286.11 EMC78881.1 - 0.045 14.0 0.5 0.096 12.9 0.5 1.5 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 BST2 PF16716.5 EMC78881.1 - 0.053 14.1 1.9 0.13 12.9 1.9 1.6 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 Herpes_UL6 PF01763.16 EMC78881.1 - 0.054 12.0 0.2 0.091 11.3 0.2 1.3 1 0 0 1 1 1 0 Herpesvirus UL6 like GIT_CC PF16559.5 EMC78881.1 - 0.079 12.8 0.5 0.079 12.8 0.5 1.8 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor APG6_N PF17675.1 EMC78881.1 - 0.089 13.3 1.7 0.17 12.4 1.7 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region SlyX PF04102.12 EMC78881.1 - 0.11 13.1 1.6 0.29 11.8 1.6 1.7 1 0 0 1 1 1 0 SlyX TMF_DNA_bd PF12329.8 EMC78881.1 - 0.59 10.2 6.7 0.11 12.5 2.8 1.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding COLFI PF01410.18 EMC78882.1 - 1e-27 96.9 0.0 1.1e-27 96.8 0.0 1.0 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain FluMu_N PF17891.1 EMC78882.1 - 0.053 13.3 0.0 0.091 12.5 0.0 1.3 1 0 0 1 1 1 0 Mu-like prophage FluMu N-terminal domain Collagen PF01391.18 EMC78883.1 - 6.3e-166 538.3 709.5 5.9e-09 35.6 33.5 21.9 2 2 17 19 19 19 18 Collagen triple helix repeat (20 copies) COLFI PF01410.18 EMC78883.1 - 4.6e-104 346.8 0.1 5.8e-104 346.5 0.1 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain VWC PF00093.18 EMC78883.1 - 1.1e-12 48.0 16.3 2.2e-12 47.1 16.3 1.5 1 0 0 1 1 1 1 von Willebrand factor type C domain TILa PF12714.7 EMC78883.1 - 0.0024 17.8 9.7 0.0024 17.8 9.7 2.2 2 0 0 2 2 2 1 TILa domain Amnionless PF14828.6 EMC78883.1 - 4.6 6.0 16.4 6.3 5.5 16.4 1.1 1 0 0 1 1 1 0 Amnionless VWA_N2 PF16164.5 EMC78883.1 - 8.5 6.6 8.7 19 5.5 8.7 1.5 1 0 0 1 1 1 0 VWA N-terminal Ald_Xan_dh_C2 PF02738.18 EMC78884.1 - 6.6e-199 661.9 0.0 9.1e-199 661.5 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 EMC78884.1 - 1.3e-52 178.0 0.0 2.5e-52 177.1 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 EMC78884.1 - 9.9e-38 128.9 1.1 1.8e-37 128.1 1.1 1.4 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.17 EMC78884.1 - 7.5e-33 112.8 0.0 2.3e-32 111.2 0.0 1.9 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.20 EMC78884.1 - 4.8e-30 103.4 0.1 1.3e-29 102.0 0.1 1.8 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.27 EMC78884.1 - 0.031 14.2 8.1 0.02 14.8 3.7 2.7 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain DUF218 PF02698.17 EMC78884.1 - 0.15 12.1 0.0 0.43 10.6 0.0 1.7 1 0 0 1 1 1 0 DUF218 domain Sulfotransfer_2 PF03567.14 EMC78885.1 - 1.2e-08 35.2 0.0 6.3e-07 29.6 0.0 2.1 1 1 1 2 2 2 2 Sulfotransferase family DUF1654 PF07867.11 EMC78885.1 - 0.025 14.3 0.4 0.06 13.1 0.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1654) DUF5600 PF18150.1 EMC78886.1 - 3.1e-44 149.9 1.8 3.1e-44 149.9 1.8 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF5600) EF-hand_4 PF12763.7 EMC78886.1 - 3.5e-19 68.7 0.2 1.8e-18 66.4 0.0 2.2 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EHD_N PF16880.5 EMC78886.1 - 2.4e-18 65.7 4.5 5.5e-18 64.6 4.5 1.7 1 0 0 1 1 1 1 N-terminal EH-domain containing protein Dynamin_N PF00350.23 EMC78886.1 - 8.9e-13 48.6 0.0 5.6e-12 46.0 0.0 2.1 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EMC78886.1 - 3.5e-09 36.7 0.0 8.6e-09 35.5 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase EF-hand_1 PF00036.32 EMC78886.1 - 0.00065 19.1 0.8 0.0025 17.2 0.2 2.4 2 0 0 2 2 1 1 EF hand GTP_EFTU PF00009.27 EMC78886.1 - 0.006 16.1 0.1 0.088 12.3 0.2 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Roc PF08477.13 EMC78886.1 - 0.0079 16.4 0.0 1.5 9.0 0.0 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EMC78886.1 - 0.013 14.9 0.0 0.11 11.9 0.0 2.1 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AIG1 PF04548.16 EMC78886.1 - 0.014 14.7 0.0 0.081 12.2 0.0 2.2 3 0 0 3 3 3 0 AIG1 family AAA_28 PF13521.6 EMC78886.1 - 0.035 14.3 0.0 0.16 12.2 0.0 2.1 2 0 0 2 2 1 0 AAA domain AAA_16 PF13191.6 EMC78886.1 - 0.047 14.1 0.2 0.31 11.4 0.0 2.4 2 2 0 2 2 2 0 AAA ATPase domain EF-hand_7 PF13499.6 EMC78886.1 - 0.1 13.1 0.1 0.44 11.0 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain pair cobW PF02492.19 EMC78886.1 - 0.14 11.8 0.0 20 4.7 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TsaE PF02367.17 EMC78886.1 - 0.16 12.0 0.0 0.39 10.7 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE EF-hand_8 PF13833.6 EMC78886.1 - 0.38 10.6 2.0 0.84 9.5 0.3 2.3 2 0 0 2 2 2 0 EF-hand domain pair Glycos_transf_2 PF00535.26 EMC78887.1 - 2.3e-22 79.6 0.0 3.6e-22 79.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 EMC78887.1 - 3.7e-20 72.5 3.4 6e-20 71.8 3.4 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 EMC78887.1 - 9.8e-05 21.9 0.0 0.00022 20.8 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_3 PF13641.6 EMC78887.1 - 0.00013 21.9 0.0 0.00022 21.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EMC78887.1 - 0.0002 20.9 0.0 0.0012 18.4 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Peptidase_C2 PF00648.21 EMC78888.1 - 4.1e-113 377.3 0.0 4.7e-113 377.1 0.0 1.0 1 0 0 1 1 1 1 Calpain family cysteine protease Peptidase_C47 PF05543.13 EMC78888.1 - 0.00045 19.8 0.3 0.00071 19.2 0.3 1.2 1 0 0 1 1 1 1 Staphopain peptidase C47 HflK_N PF12221.8 EMC78888.1 - 0.86 9.7 5.5 1.2 9.2 0.0 2.5 2 0 0 2 2 2 0 Bacterial membrane protein N terminal HSF_DNA-bind PF00447.17 EMC78889.1 - 1.9e-10 41.2 0.0 2.1e-10 41.1 0.0 1.0 1 0 0 1 1 1 1 HSF-type DNA-binding Acyltransferase PF01553.21 EMC78890.1 - 4.9e-23 81.2 0.0 8e-23 80.5 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 EMC78890.1 - 5.8e-19 68.0 1.5 1.3e-18 66.9 0.1 2.2 2 0 0 2 2 2 1 Acyltransferase C-terminus Lbh PF15317.6 EMC78891.1 - 2.9e-28 98.7 2.6 3.3e-28 98.5 2.6 1.1 1 0 0 1 1 1 1 Cardiac transcription factor regulator, Developmental protein Yippee-Mis18 PF03226.14 EMC78892.1 - 3.6e-14 52.8 0.1 4.3e-14 52.6 0.1 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly SelR PF01641.18 EMC78892.1 - 0.0011 19.1 0.0 0.0014 18.7 0.0 1.2 1 0 0 1 1 1 1 SelR domain RIG-I_C-RD PF11648.8 EMC78892.1 - 0.0015 18.8 0.1 0.0021 18.3 0.1 1.2 1 0 0 1 1 1 1 C-terminal domain of RIG-I HNH_5 PF14279.6 EMC78892.1 - 0.0031 17.3 0.2 0.041 13.7 0.0 2.2 2 0 0 2 2 2 1 HNH endonuclease Endonuclease_7 PF02945.15 EMC78892.1 - 0.0082 16.0 0.7 0.042 13.8 0.4 2.0 1 1 1 2 2 2 1 Recombination endonuclease VII HECT_2 PF09814.9 EMC78892.1 - 0.072 11.9 0.9 0.23 10.3 0.0 1.8 1 1 1 2 2 2 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Sgf11 PF08209.11 EMC78892.1 - 0.19 11.3 2.4 5.9 6.5 0.1 2.3 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Ank_5 PF13857.6 EMC78893.1 - 6.8e-07 29.5 0.0 5.6e-06 26.5 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC78893.1 - 8.5e-07 29.5 0.2 0.00081 19.9 0.0 2.6 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC78893.1 - 7.8e-06 25.9 1.0 0.046 14.3 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EMC78893.1 - 3.1e-05 24.4 0.2 0.033 14.8 0.3 3.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EMC78893.1 - 0.0026 18.1 0.0 0.0026 18.1 0.0 2.8 4 0 0 4 4 4 1 Ankyrin repeat ALMS_repeat PF18727.1 EMC78893.1 - 0.068 13.1 0.2 0.63 10.0 0.0 2.3 2 0 0 2 2 2 0 Alstrom syndrome repeat Steroid_dh PF02544.16 EMC78894.1 - 2e-58 196.6 1.0 2.3e-58 196.5 1.0 1.0 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EMC78894.1 - 2.7e-06 27.1 0.1 2.9e-06 27.0 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Ferric_reduct PF01794.19 EMC78894.1 - 0.015 15.4 0.0 0.035 14.2 0.0 1.6 1 0 0 1 1 1 0 Ferric reductase like transmembrane component ATG27 PF09451.10 EMC78894.1 - 0.1 12.4 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Autophagy-related protein 27 Methyltr_RsmB-F PF01189.17 EMC78895.1 - 1.1e-39 136.2 0.0 1e-35 123.2 0.0 2.5 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EMC78895.1 - 0.0039 17.3 0.0 0.008 16.3 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase Glutaredoxin PF00462.24 EMC78895.1 - 0.15 12.3 0.1 0.43 10.8 0.1 1.8 1 0 0 1 1 1 0 Glutaredoxin UQ_con PF00179.26 EMC78896.1 - 1.1e-08 34.9 0.0 1.2e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EMC78896.1 - 0.0001 22.0 0.0 0.00012 21.7 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B Med10 PF09748.9 EMC78897.1 - 1.8e-25 89.2 0.9 1.1e-24 86.7 0.9 1.8 1 1 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex Sigma70_r1_1 PF03979.14 EMC78897.1 - 0.014 15.4 1.4 4.9 7.3 0.0 2.5 2 2 0 2 2 2 0 Sigma-70 factor, region 1.1 DUF3198 PF11433.8 EMC78897.1 - 0.031 14.2 0.0 0.08 12.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3198) DUF2203 PF09969.9 EMC78897.1 - 0.042 14.6 0.1 2.9 8.6 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF3958 PF13125.6 EMC78897.1 - 0.087 13.0 1.4 0.15 12.2 0.1 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3958) DUF5524 PF17662.1 EMC78898.1 - 8.6e-87 291.2 6.1 9.8e-87 291.0 6.1 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5524) PNP_UDP_1 PF01048.20 EMC78899.1 - 3.9e-27 95.0 0.0 4.5e-27 94.8 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily TPR_MalT PF17874.1 EMC78899.1 - 0.089 12.1 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 MalT-like TPR region GyrB_insert PF18053.1 EMC78900.1 - 0.03 14.2 0.0 0.059 13.3 0.0 1.5 1 0 0 1 1 1 0 DNA gyrase B subunit insert domain DUF3045 PF11243.8 EMC78901.1 - 0.013 15.6 0.0 0.021 15.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3045) Duffy_binding PF05424.11 EMC78902.1 - 2.9 7.9 5.2 3.6 7.6 0.4 3.2 3 1 0 3 3 3 0 Duffy binding domain VWC PF00093.18 EMC78903.1 - 1.8e-10 41.0 55.2 3.3e-09 36.9 16.4 4.0 4 0 0 4 4 4 3 von Willebrand factor type C domain Pacifastin_I PF05375.13 EMC78903.1 - 0.0001 21.9 4.1 0.0001 21.9 4.1 4.0 4 0 0 4 4 4 2 Pacifastin inhibitor (LCMII) Ycf1 PF05758.12 EMC78903.1 - 0.12 10.2 0.1 0.15 9.9 0.1 1.1 1 0 0 1 1 1 0 Ycf1 zf-CCCH_2 PF14608.6 EMC78903.1 - 0.74 10.4 16.6 0.35 11.4 0.9 4.0 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger B12D PF06522.11 EMC78905.1 - 4.7e-23 80.8 0.0 5.4e-23 80.6 0.0 1.0 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit VHL PF01847.16 EMC78905.1 - 0.093 12.7 0.0 0.1 12.5 0.0 1.1 1 0 0 1 1 1 0 VHL beta domain Cation_efflux PF01545.21 EMC78906.1 - 1.2e-35 123.0 14.6 2.5e-33 115.5 9.6 2.2 2 0 0 2 2 2 2 Cation efflux family DUF1282 PF06930.12 EMC78906.1 - 0.0081 16.0 6.5 0.47 10.2 5.4 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1282) Polysacc_synt_C PF14667.6 EMC78906.1 - 0.023 14.8 1.6 0.023 14.8 1.6 2.2 3 0 0 3 3 3 0 Polysaccharide biosynthesis C-terminal domain CitMHS PF03600.16 EMC78906.1 - 0.35 10.0 4.9 0.24 10.5 3.4 1.5 2 0 0 2 2 2 0 Citrate transporter Snapin_Pallidin PF14712.6 EMC78907.1 - 3.6e-22 78.6 3.3 4.1e-22 78.4 3.3 1.1 1 0 0 1 1 1 1 Snapin/Pallidin DUF2353 PF09789.9 EMC78907.1 - 0.0077 15.6 3.3 0.025 14.0 3.4 1.7 1 1 1 2 2 2 1 Uncharacterized coiled-coil protein (DUF2353) Tup_N PF08581.10 EMC78907.1 - 0.069 13.5 3.4 0.62 10.4 0.5 2.1 2 0 0 2 2 2 0 Tup N-terminal Pyr_redox_2 PF07992.14 EMC78908.1 - 1.9e-16 60.1 0.0 5.5e-11 42.2 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Tox-PL-2 PF15643.6 EMC78908.1 - 0.1 12.7 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Papain fold toxin 2 AAA_18 PF13238.6 EMC78909.1 - 0.0087 16.6 0.0 0.015 15.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain Peptidase_A22B PF04258.13 EMC78910.1 - 6.2e-81 272.0 19.3 9.2e-81 271.5 19.3 1.2 1 0 0 1 1 1 1 Signal peptide peptidase PA PF02225.22 EMC78910.1 - 6.8e-08 32.4 0.0 1.4e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 PA domain Presenilin PF01080.17 EMC78910.1 - 0.0016 17.3 28.4 0.01 14.7 5.0 2.1 2 0 0 2 2 2 2 Presenilin MMPL PF03176.15 EMC78910.1 - 0.3 10.0 4.6 3.3 6.5 0.0 2.4 2 0 0 2 2 2 0 MMPL family CCSMST1 PF15013.6 EMC78910.1 - 7.9 6.7 5.5 48 4.2 0.1 3.0 3 0 0 3 3 3 0 CCSMST1 family LSDAT_euk PF18139.1 EMC78911.1 - 8.5e-119 395.8 0.0 1.3e-118 395.3 0.0 1.3 1 0 0 1 1 1 1 SLOG in TRPM Alpha_kinase PF02816.18 EMC78911.1 - 3.1e-38 131.7 0.0 8.8e-38 130.3 0.0 1.7 1 0 0 1 1 1 1 Alpha-kinase family TRPM_tetra PF16519.5 EMC78911.1 - 9.4e-27 92.9 1.2 1.9e-26 91.9 1.2 1.6 1 0 0 1 1 1 1 Tetramerisation domain of TRPM LSDAT_prok PF18171.1 EMC78911.1 - 1.6e-19 69.9 0.6 3e-19 69.1 0.6 1.4 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote Ion_trans PF00520.31 EMC78911.1 - 4.6e-09 35.9 22.0 7.2e-09 35.2 22.0 1.3 1 0 0 1 1 1 1 Ion transport protein UCH PF00443.29 EMC78912.1 - 8.3e-81 271.3 5.1 8.3e-81 271.3 5.1 2.2 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase USP8_dimer PF08969.11 EMC78912.1 - 1.8e-30 105.5 6.2 1.8e-30 105.5 6.2 2.5 2 0 0 2 2 2 1 USP8 dimerisation domain UCH_1 PF13423.6 EMC78912.1 - 1.1e-20 74.5 4.0 1.1e-20 74.5 4.0 2.3 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 EMC78912.1 - 6.2e-07 29.9 0.0 3.4e-06 27.5 0.0 2.4 1 0 0 1 1 1 1 Rhodanese-like domain Metallothio_Pro PF02069.16 EMC78912.1 - 0.13 12.5 0.7 0.38 11.0 0.5 1.9 2 0 0 2 2 2 0 Prokaryotic metallothionein Ank_2 PF12796.7 EMC78913.1 - 1.4e-37 128.1 4.8 1.4e-15 57.6 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC78913.1 - 3.9e-25 87.6 0.9 2.8e-08 33.9 0.0 4.5 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EMC78913.1 - 1.2e-24 85.5 0.5 7.7e-09 35.6 0.1 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 EMC78913.1 - 7.8e-23 80.5 0.3 5.4e-10 39.6 0.1 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC78913.1 - 7.5e-22 75.1 0.1 2.5e-06 27.4 0.0 5.4 5 0 0 5 5 5 3 Ankyrin repeat CCDC84 PF14968.6 EMC78913.1 - 0.075 12.7 0.0 0.1 12.2 0.0 1.1 1 0 0 1 1 1 0 Coiled coil protein 84 Pyridoxal_deC PF00282.19 EMC78914.1 - 3.2e-167 556.0 0.0 4e-167 555.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EMC78914.1 - 0.00045 19.6 0.0 0.00078 18.8 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EMC78914.1 - 0.024 13.8 0.0 0.039 13.1 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Amidinotransf PF02274.17 EMC78915.1 - 0.037 13.1 0.0 6.6 5.7 0.0 3.1 3 1 0 3 3 3 0 Amidinotransferase PDEase_I PF00233.19 EMC78916.1 - 1.2e-96 323.1 1.5 2e-96 322.3 1.5 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase PAS PF00989.25 EMC78916.1 - 1.8e-12 47.3 0.3 7.8e-12 45.2 0.0 2.2 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 EMC78916.1 - 2.3e-12 47.1 0.1 7.4e-12 45.4 0.1 1.9 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.12 EMC78916.1 - 1.1e-06 28.8 0.0 2.6e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EMC78916.1 - 6.9e-06 26.3 0.0 2.5e-05 24.5 0.0 2.0 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EMC78916.1 - 0.014 15.4 0.0 0.046 13.8 0.0 1.9 1 0 0 1 1 1 0 PAS domain Nrap_D2 PF17403.2 EMC78916.1 - 0.1 12.3 0.4 0.32 10.8 0.4 1.7 1 1 0 1 1 1 0 Nrap protein PAP/OAS-like domain WH1 PF00568.23 EMC78917.1 - 3.4e-36 123.6 0.4 7.9e-36 122.4 0.4 1.6 1 0 0 1 1 1 1 WH1 domain GAS PF13851.6 EMC78917.1 - 7e-06 25.5 42.4 0.00013 21.4 15.1 3.5 1 1 1 3 3 3 2 Growth-arrest specific micro-tubule binding Macoilin PF09726.9 EMC78917.1 - 7.9e-06 24.7 24.6 9.5e-06 24.5 24.6 1.1 1 0 0 1 1 1 1 Macoilin family MAD PF05557.13 EMC78917.1 - 9e-05 21.0 41.0 0.0039 15.6 20.3 2.1 1 1 1 2 2 2 2 Mitotic checkpoint protein DMPK_coil PF08826.10 EMC78917.1 - 0.0001 22.4 3.7 0.0001 22.4 3.7 3.8 2 1 1 3 3 3 1 DMPK coiled coil domain like IFT57 PF10498.9 EMC78917.1 - 0.00017 20.7 25.4 0.00026 20.1 25.4 1.2 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Uso1_p115_C PF04871.13 EMC78917.1 - 0.0013 19.1 16.3 0.0013 19.1 16.3 3.3 1 1 2 3 3 3 1 Uso1 / p115 like vesicle tethering protein, C terminal region DUF4201 PF13870.6 EMC78917.1 - 0.0054 16.5 6.3 0.0054 16.5 6.3 3.3 2 1 0 3 3 2 1 Domain of unknown function (DUF4201) Phage_GP20 PF06810.11 EMC78917.1 - 0.0054 16.5 9.7 0.0054 16.5 9.7 3.7 2 1 2 4 4 3 1 Phage minor structural protein GP20 HemX PF04375.14 EMC78917.1 - 0.0076 15.6 10.2 0.0076 15.6 10.2 3.4 1 1 2 3 3 2 1 HemX, putative uroporphyrinogen-III C-methyltransferase FlaC_arch PF05377.11 EMC78917.1 - 0.0087 16.4 21.7 1.9 9.0 0.5 4.8 2 2 2 4 4 4 1 Flagella accessory protein C (FlaC) ATG16 PF08614.11 EMC78917.1 - 0.011 15.9 21.0 0.011 15.9 21.0 3.1 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Effector_1 PF04518.12 EMC78917.1 - 0.014 14.6 0.6 0.014 14.6 0.6 3.0 1 1 2 3 3 3 0 Effector from type III secretion system TolA_bind_tri PF16331.5 EMC78917.1 - 0.016 15.3 23.5 0.21 11.7 7.3 3.8 1 1 2 3 3 3 0 TolA binding protein trimerisation BST2 PF16716.5 EMC78917.1 - 0.018 15.6 9.6 0.018 15.6 9.6 4.1 2 1 2 4 4 3 0 Bone marrow stromal antigen 2 Laminin_II PF06009.12 EMC78917.1 - 0.058 13.4 22.9 0.097 12.7 6.9 3.0 2 1 1 3 3 3 0 Laminin Domain II DUF948 PF06103.11 EMC78917.1 - 0.062 13.6 6.5 2.6 8.3 0.3 2.8 3 1 0 3 3 2 0 Bacterial protein of unknown function (DUF948) CALCOCO1 PF07888.11 EMC78917.1 - 0.065 12.1 36.6 0.24 10.2 15.9 2.6 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Corona_S2 PF01601.16 EMC78917.1 - 0.081 11.4 2.5 0.14 10.6 2.5 1.3 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein FPP PF05911.11 EMC78917.1 - 0.1 10.8 43.9 0.1 10.8 29.2 2.2 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil T3SSipB PF16535.5 EMC78917.1 - 0.13 12.7 24.0 0.29 11.6 18.0 2.9 2 1 0 2 2 2 0 Type III cell invasion protein SipB CENP-H PF05837.12 EMC78917.1 - 0.14 12.6 42.5 0.081 13.3 10.8 4.0 2 1 2 4 4 4 0 Centromere protein H (CENP-H) TMF_TATA_bd PF12325.8 EMC78917.1 - 0.16 12.2 38.9 0.029 14.6 13.9 3.1 2 1 1 3 3 2 0 TATA element modulatory factor 1 TATA binding DUF3450 PF11932.8 EMC78917.1 - 0.18 11.1 33.7 0.12 11.6 3.0 4.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) HAP1_N PF04849.13 EMC78917.1 - 0.24 10.6 42.1 0.058 12.6 28.1 2.5 2 1 1 3 3 2 0 HAP1 N-terminal conserved region DHR10 PF18595.1 EMC78917.1 - 0.29 11.2 51.6 0.19 11.8 8.7 4.2 2 1 2 4 4 4 0 Designed helical repeat protein 10 domain DUF3584 PF12128.8 EMC78917.1 - 0.35 8.3 35.7 0.0086 13.7 28.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Fez1 PF06818.15 EMC78917.1 - 0.43 11.0 39.6 0.16 12.4 9.5 3.1 1 1 1 2 2 1 0 Fez1 Mod_r PF07200.13 EMC78917.1 - 0.57 10.3 38.1 1.1 9.3 20.8 3.1 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein YabA PF06156.13 EMC78917.1 - 0.57 10.8 32.4 0.34 11.6 7.4 4.3 1 1 2 4 4 4 0 Initiation control protein YabA DUF812 PF05667.11 EMC78917.1 - 0.59 8.9 40.7 2.3 7.0 24.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF812) Sec34 PF04136.15 EMC78917.1 - 0.63 9.9 26.2 0.32 10.9 4.9 3.4 2 1 2 4 4 4 0 Sec34-like family NPV_P10 PF05531.12 EMC78917.1 - 0.72 10.3 11.3 9.7 6.7 0.7 3.5 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein FUSC PF04632.12 EMC78917.1 - 0.8 8.2 12.6 1 7.8 4.2 2.1 1 1 1 2 2 2 0 Fusaric acid resistance protein family TACC_C PF05010.14 EMC78917.1 - 0.89 9.3 34.5 0.024 14.4 25.4 2.6 2 1 1 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal EzrA PF06160.12 EMC78917.1 - 1.2 7.2 32.5 0.025 12.8 25.3 1.8 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA Lebercilin PF15619.6 EMC78917.1 - 1.3 8.7 44.3 0.7 9.5 20.8 3.5 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF3461 PF11944.8 EMC78917.1 - 1.8 8.7 23.5 0.17 12.0 6.7 3.1 2 1 2 4 4 3 0 Protein of unknown function (DUF3461) BLOC1_2 PF10046.9 EMC78917.1 - 1.9 8.8 25.1 0.63 10.4 2.6 3.8 2 1 2 4 4 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Leu_zip PF15294.6 EMC78917.1 - 2.1 7.8 34.7 0.3 10.6 28.3 2.3 1 1 1 2 2 1 0 Leucine zipper MscS_porin PF12795.7 EMC78917.1 - 2.1 7.9 38.1 0.6 9.6 22.1 3.0 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain VGPC1_C PF16799.5 EMC78917.1 - 2.3 8.3 22.1 0.2 11.7 4.1 3.6 2 2 1 3 3 2 0 C-terminal membrane-localisation domain of ion-channel, VCN1 Spc7 PF08317.11 EMC78917.1 - 2.3 7.0 42.1 0.36 9.7 21.7 2.9 1 1 2 3 3 3 0 Spc7 kinetochore protein Prominin PF05478.11 EMC78917.1 - 2.6 5.9 17.9 9.2 4.1 17.3 1.9 1 1 0 1 1 1 0 Prominin KASH_CCD PF14662.6 EMC78917.1 - 2.8 7.7 47.2 0.087 12.6 24.0 3.1 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH TMEM192 PF14802.6 EMC78917.1 - 2.8 7.0 8.8 1.4 8.0 2.8 2.6 1 1 1 2 2 2 0 TMEM192 family Filament PF00038.21 EMC78917.1 - 2.9 7.4 34.8 0.87 9.1 21.8 2.7 1 1 1 3 3 3 0 Intermediate filament protein ADIP PF11559.8 EMC78917.1 - 3 7.9 44.2 0.92 9.6 4.6 3.9 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding DUF4200 PF13863.6 EMC78917.1 - 3.5 8.1 43.7 2.1 8.8 15.2 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) DUF1664 PF07889.12 EMC78917.1 - 3.7 7.6 23.1 7.1 6.7 7.2 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) AIP3 PF03915.13 EMC78917.1 - 3.8 6.5 30.5 1 8.4 13.8 2.1 1 1 1 2 2 2 0 Actin interacting protein 3 ERM PF00769.19 EMC78917.1 - 4 7.2 51.0 0.41 10.4 38.8 2.9 1 1 1 2 2 2 0 Ezrin/radixin/moesin family AAA_13 PF13166.6 EMC78917.1 - 4.2 5.9 31.2 0.23 10.1 24.3 2.0 1 1 0 2 2 2 0 AAA domain UPF0242 PF06785.11 EMC78917.1 - 4.6 7.3 42.0 0.099 12.7 24.1 2.7 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Cep57_CLD_2 PF14197.6 EMC78917.1 - 4.6 7.4 39.8 28 4.9 16.9 4.1 1 1 2 3 3 3 0 Centrosome localisation domain of PPC89 DUF4600 PF15372.6 EMC78917.1 - 4.8 7.6 26.7 1.3 9.5 14.8 3.3 2 1 2 4 4 3 0 Domain of unknown function (DUF4600) Dor1 PF04124.12 EMC78917.1 - 4.9 5.8 24.3 0.21 10.2 18.1 1.9 2 1 0 2 2 1 0 Dor1-like family Baculo_PEP_C PF04513.12 EMC78917.1 - 4.9 7.2 13.3 6.3 6.8 0.8 3.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPR_MLP1_2 PF07926.12 EMC78917.1 - 5.3 7.1 52.9 0.19 11.8 5.8 4.0 2 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein ApoO PF09769.9 EMC78917.1 - 5.8 6.9 8.3 9.1 6.2 0.1 3.1 3 1 0 3 3 2 0 Apolipoprotein O FH2 PF02181.23 EMC78917.1 - 6.2 5.8 24.5 14 4.7 5.9 3.7 2 1 1 3 3 3 0 Formin Homology 2 Domain APG6_N PF17675.1 EMC78917.1 - 6.4 7.3 50.9 0.23 12.0 6.7 3.6 1 1 2 3 3 2 0 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 EMC78917.1 - 7.1 6.6 48.6 0.88 9.6 2.7 3.9 2 1 1 3 3 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF2353 PF09789.9 EMC78917.1 - 7.2 5.9 34.9 1.7 8.0 23.2 2.6 1 1 1 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) Golgin_A5 PF09787.9 EMC78917.1 - 8.6 5.7 40.7 0.29 10.6 19.9 2.8 1 1 2 3 3 3 0 Golgin subfamily A member 5 DUF4559 PF15112.6 EMC78917.1 - 8.7 5.9 21.9 2.6 7.6 18.4 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4559) Seryl_tRNA_N PF02403.22 EMC78917.1 - 8.9 6.6 36.5 0.84 9.9 12.8 3.9 2 1 3 5 5 4 0 Seryl-tRNA synthetase N-terminal domain COG6 PF06419.11 EMC78917.1 - 9.3 4.3 28.0 0.35 9.0 9.6 2.6 2 1 1 3 3 2 0 Conserved oligomeric complex COG6 KLRAQ PF10205.9 EMC78917.1 - 9.6 6.5 33.4 5.9 7.2 9.5 4.3 2 1 2 4 4 4 0 Predicted coiled-coil domain-containing protein RAM PF15320.6 EMC78918.1 - 2.3e-20 72.9 1.8 2.6e-20 72.8 1.8 1.0 1 0 0 1 1 1 1 mRNA cap methylation, RNMT-activating mini protein DUF167 PF02594.16 EMC78919.1 - 1.8e-20 72.8 0.3 2.1e-20 72.6 0.3 1.1 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 DUF410 PF04190.13 EMC78919.1 - 0.16 11.7 0.0 0.17 11.7 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF410) PHR PF08005.12 EMC78920.1 - 2.4e-50 171.1 0.8 3.6e-50 170.6 0.8 1.3 1 0 0 1 1 1 1 PHR domain BACK PF07707.15 EMC78920.1 - 9.1e-10 38.6 0.2 1.4e-08 34.7 0.1 2.6 1 1 1 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 EMC78920.1 - 7.1e-07 29.4 0.3 2.4e-05 24.5 0.0 2.5 1 1 1 2 2 2 1 BTB/POZ domain DUF2781 PF10914.8 EMC78921.1 - 5.9e-21 75.4 2.9 5.9e-21 75.4 2.9 3.3 2 1 1 3 3 3 1 Protein of unknown function (DUF2781) Thyroglob_assoc PF16597.5 EMC78922.1 - 0.22 11.8 0.0 0.32 11.3 0.0 1.2 1 0 0 1 1 1 0 Thyroglobulin_1 repeat associated disordered domain HSP20 PF00011.21 EMC78923.1 - 9.6e-08 32.1 0.1 1.2e-07 31.8 0.1 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family YabP PF07873.11 EMC78923.1 - 0.017 14.9 0.0 0.028 14.2 0.0 1.2 1 0 0 1 1 1 0 YabP family SRRM_C PF15230.6 EMC78924.1 - 9.8e-29 99.7 30.2 9.8e-29 99.7 30.2 10.0 4 3 5 9 9 9 1 Serine/arginine repetitive matrix protein C-terminus Ig_3 PF13927.6 EMC78925.1 - 1.1e-25 90.0 2.0 8.3e-12 45.5 0.2 3.2 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 EMC78925.1 - 9.2e-22 76.9 0.0 2.1e-11 43.7 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 EMC78925.1 - 3.3e-18 65.7 1.1 9.4e-09 35.3 0.0 3.6 3 1 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 EMC78925.1 - 1.7e-16 60.3 1.6 2.2e-05 24.7 0.1 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 EMC78925.1 - 6.7e-13 48.8 1.4 6.7e-08 32.7 0.0 4.0 3 1 0 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC78925.1 - 4.8e-08 33.0 3.4 0.00094 19.2 0.1 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 EMC78925.1 - 0.0016 18.8 0.3 1.5 9.3 0.0 3.6 3 2 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 EMC78925.1 - 0.0036 17.5 1.0 7.1 7.0 0.0 4.5 5 0 0 5 5 5 1 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 EMC78925.1 - 0.007 15.9 0.0 0.15 11.7 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain Izumo-Ig PF16706.5 EMC78925.1 - 0.13 12.3 0.1 3.6 7.7 0.0 2.3 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain YPEB PF14620.6 EMC78926.1 - 0.048 13.0 2.3 0.051 12.9 2.3 1.0 1 0 0 1 1 1 0 YpeB sporulation DEAD PF00270.29 EMC78927.1 - 2.8e-50 170.5 0.0 6.9e-50 169.2 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC78927.1 - 1e-24 87.0 0.0 6.1e-24 84.5 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 EMC78927.1 - 7.8e-19 67.7 7.4 1.9e-18 66.4 7.4 1.7 1 0 0 1 1 1 1 DBP10CT (NUC160) domain ResIII PF04851.15 EMC78927.1 - 1.6e-08 34.8 0.3 3.2e-07 30.5 0.0 3.0 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit PAPS_reduct PF01507.19 EMC78927.1 - 0.007 16.4 0.0 0.022 14.8 0.0 1.8 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Ion_trans PF00520.31 EMC78928.1 - 2.1e-53 181.1 62.8 3.1e-27 95.4 30.9 2.2 2 0 0 2 2 2 2 Ion transport protein ECSCR PF15820.5 EMC78928.1 - 0.13 12.1 0.1 0.69 9.8 0.2 2.2 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator Pilin_N PF07790.11 EMC78928.1 - 0.17 12.8 0.1 1.2 10.1 0.1 2.2 2 0 0 2 2 2 0 Archaeal Type IV pilin, N-terminal PALP PF00291.25 EMC78929.1 - 7.2e-53 179.9 0.5 1.3e-43 149.5 0.0 2.0 1 1 1 2 2 2 2 Pyridoxal-phosphate dependent enzyme TP_methylase PF00590.20 EMC78929.1 - 0.042 13.8 0.2 4.2 7.2 0.0 2.3 2 0 0 2 2 2 0 Tetrapyrrole (Corrin/Porphyrin) Methylases IFRD PF05004.13 EMC78929.1 - 0.2 10.7 0.1 0.28 10.3 0.1 1.1 1 0 0 1 1 1 0 Interferon-related developmental regulator (IFRD) RRM_1 PF00076.22 EMC78930.1 - 3.2e-89 292.8 4.8 2.3e-19 69.0 0.0 6.4 6 0 0 6 6 6 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMC78930.1 - 3.6e-08 33.4 0.0 1.3 9.2 0.0 5.8 6 0 0 6 6 6 3 RNA recognition motif RRM_Rrp7 PF17799.1 EMC78930.1 - 2.3e-07 30.7 1.1 0.65 9.8 0.0 5.0 5 0 0 5 5 5 2 Rrp7 RRM-like N-terminal domain RRM_3 PF08777.11 EMC78930.1 - 5.9e-07 29.5 7.4 2.7 8.1 0.1 7.4 7 2 1 8 8 8 2 RNA binding motif RRM_occluded PF16842.5 EMC78930.1 - 3.4e-05 23.6 0.0 6.9 6.6 0.0 4.9 5 0 0 5 5 5 2 Occluded RNA-recognition motif DnaJ-X PF14308.6 EMC78930.1 - 0.00054 19.5 0.0 0.00054 19.5 0.0 2.9 3 0 0 3 3 3 1 X-domain of DnaJ-containing Limkain-b1 PF11608.8 EMC78930.1 - 0.0019 18.2 0.1 0.97 9.5 0.0 4.9 5 1 0 5 5 5 1 Limkain b1 Nup35_RRM_2 PF14605.6 EMC78930.1 - 0.0025 17.8 0.3 23 5.1 0.0 4.6 4 0 0 4 4 4 0 Nup53/35/40-type RNA recognition motif T-box PF00907.22 EMC78932.1 - 2.5e-53 181.1 0.0 4.8e-46 157.3 0.0 2.3 2 0 0 2 2 2 2 T-box Sulfotransfer_2 PF03567.14 EMC78933.1 - 3.9e-31 108.9 0.1 5e-31 108.5 0.1 1.1 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 EMC78933.1 - 0.015 14.8 0.0 0.024 14.1 0.0 1.4 1 0 0 1 1 1 0 Sulfotransferase domain DICT PF10069.9 EMC78933.1 - 0.048 13.4 0.6 0.76 9.6 0.1 2.2 2 0 0 2 2 2 0 Sensory domain in DIguanylate Cyclases and Two-component system Pkinase PF00069.25 EMC78934.1 - 3.7e-65 219.9 0.0 6.1e-65 219.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC78934.1 - 1.6e-40 139.0 0.0 2.4e-40 138.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.16 EMC78934.1 - 2.6e-19 69.1 9.3 6.1e-15 55.1 1.3 2.4 2 0 0 2 2 2 2 Hr1 repeat Pkinase_C PF00433.24 EMC78934.1 - 3.3e-11 43.7 0.4 1e-10 42.2 0.4 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 EMC78934.1 - 2.3e-07 30.4 0.0 1.4e-06 27.8 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EMC78934.1 - 0.00011 21.3 0.1 0.00053 19.0 0.0 1.9 2 0 0 2 2 2 1 Haspin like kinase domain C2 PF00168.30 EMC78934.1 - 0.011 16.0 0.0 0.024 14.9 0.0 1.5 1 0 0 1 1 1 0 C2 domain TFIIB PF00382.19 EMC78935.1 - 2.3e-52 174.9 1.8 1.2e-25 89.3 0.1 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EMC78935.1 - 2e-14 52.8 0.3 3.3e-14 52.1 0.3 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 EMC78935.1 - 3.1e-09 36.6 0.0 7.7e-07 28.9 0.0 2.1 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 EMC78935.1 - 0.0019 18.3 0.4 0.07 13.2 0.0 2.4 1 1 1 2 2 2 1 Cyclin, C-terminal domain RB_B PF01857.20 EMC78935.1 - 0.0033 17.4 0.1 0.0079 16.2 0.1 1.6 2 0 0 2 2 2 1 Retinoblastoma-associated protein B domain Sigma70_r4 PF04545.16 EMC78935.1 - 0.032 13.7 0.0 0.26 10.8 0.0 2.2 2 0 0 2 2 2 0 Sigma-70, region 4 Pannexin_like PF12534.8 EMC78936.1 - 2.9e-125 418.0 15.6 3.8e-125 417.6 15.6 1.2 1 0 0 1 1 1 1 Pannexin-like TM region of LRRC8 LRR_8 PF13855.6 EMC78936.1 - 6.2e-27 93.1 53.4 1.3e-11 44.0 3.6 7.9 5 2 3 8 8 8 6 Leucine rich repeat LRR_4 PF12799.7 EMC78936.1 - 1.5e-16 60.2 64.6 1.4e-05 25.3 0.3 9.6 5 2 5 10 10 10 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC78936.1 - 1.7e-09 37.7 8.1 4.1e-05 23.5 1.3 3.7 1 1 3 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC78936.1 - 7.1e-09 35.4 16.6 0.0075 15.8 0.5 3.7 1 1 2 3 3 3 3 Leucine-rich repeat Pannexin_like PF12534.8 EMC78937.1 - 6.8e-150 499.0 4.8 9.4e-150 498.5 4.8 1.2 1 0 0 1 1 1 1 Pannexin-like TM region of LRRC8 LRR_8 PF13855.6 EMC78937.1 - 1.7e-28 98.2 35.0 4.5e-10 39.1 1.1 7.6 3 2 4 7 7 7 5 Leucine rich repeat LRR_4 PF12799.7 EMC78937.1 - 4.8e-20 71.3 40.9 0.00025 21.4 0.2 9.7 6 3 3 10 10 10 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC78937.1 - 1.4e-08 34.7 10.5 3.6e-05 23.7 0.4 4.3 2 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC78937.1 - 0.00022 20.8 13.9 0.2 11.2 0.3 4.2 2 1 1 4 4 4 2 Leucine-rich repeat LRR_6 PF13516.6 EMC78937.1 - 0.11 12.6 25.8 0.74 10.0 0.1 8.6 10 0 0 10 10 10 0 Leucine Rich repeat DUSP PF06337.12 EMC78937.1 - 0.14 12.8 0.2 1.5 9.5 0.0 2.6 2 0 0 2 2 2 0 DUSP domain LRR_1 PF00560.33 EMC78937.1 - 0.27 11.9 33.6 5.7 7.9 0.0 11.0 11 0 0 11 11 11 0 Leucine Rich Repeat Pannexin_like PF12534.8 EMC78938.1 - 2.2e-157 523.6 5.9 3.2e-157 523.1 5.9 1.3 1 0 0 1 1 1 1 Pannexin-like TM region of LRRC8 LRR_8 PF13855.6 EMC78938.1 - 1.2e-29 101.8 31.6 7e-10 38.5 0.7 7.3 3 2 5 8 8 8 6 Leucine rich repeat LRR_4 PF12799.7 EMC78938.1 - 2.5e-25 88.1 38.9 3.2e-06 27.4 1.1 9.0 4 2 7 11 11 11 10 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC78938.1 - 2.8e-11 43.2 14.6 6.1e-06 25.9 1.6 3.7 1 1 1 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 EMC78938.1 - 2.7e-07 30.2 32.8 0.35 11.6 0.1 10.6 10 2 0 10 10 10 4 Leucine Rich Repeat AKAP95 PF04988.12 EMC78939.1 - 9.4e-74 247.1 12.5 1.9e-73 246.1 12.5 1.5 1 0 0 1 1 1 1 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_2 PF12756.7 EMC78939.1 - 0.087 13.2 9.7 1.2 9.6 1.3 2.4 1 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) DUF678 PF05077.12 EMC78939.1 - 0.095 12.8 0.4 5.3 7.2 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF678) zf-Di19 PF05605.12 EMC78939.1 - 0.21 11.9 7.8 1.1 9.6 0.6 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Sec63 PF02889.16 EMC78940.1 - 8.6e-49 166.0 2.8 8.6e-49 166.0 2.8 1.6 2 0 0 2 2 2 1 Sec63 Brl domain DEAD PF00270.29 EMC78940.1 - 9.2e-26 90.7 0.0 3.9e-25 88.6 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EMC78940.1 - 1.2e-12 48.2 0.0 4e-12 46.5 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EMC78940.1 - 8.7e-11 42.2 0.2 6.5e-10 39.3 0.0 2.5 2 1 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EMC78940.1 - 0.0021 18.4 0.0 0.012 15.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain Pkinase PF00069.25 EMC78941.1 - 2.5e-48 164.7 0.1 4.1e-26 91.9 0.1 3.2 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EMC78941.1 - 1.4e-17 63.8 0.0 7.7e-14 51.6 0.0 2.8 3 0 0 3 3 3 2 Protein tyrosine kinase APH PF01636.23 EMC78941.1 - 0.01 15.8 0.0 0.8 9.6 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Shadoo PF14999.6 EMC78941.1 - 0.056 13.5 1.1 0.077 13.1 0.1 1.7 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective TPR_14 PF13428.6 EMC78941.1 - 0.16 12.8 0.2 55 5.0 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Kdo PF06293.14 EMC78941.1 - 0.16 11.3 0.0 0.3 10.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EMC78941.1 - 0.22 10.8 1.4 16 4.7 0.0 3.0 4 0 0 4 4 4 0 Kinase-like Zona_pellucida PF00100.23 EMC78942.1 - 1.8e-40 139.3 0.7 3.7e-40 138.4 0.7 1.5 1 0 0 1 1 1 1 Zona pellucida-like domain BET PF17035.5 EMC78943.1 - 2.6e-27 94.8 0.2 2.6e-27 94.8 0.2 2.8 2 0 0 2 2 2 1 Bromodomain extra-terminal - transcription regulation Bromodomain PF00439.25 EMC78943.1 - 1e-09 38.3 0.0 2.8e-09 36.9 0.0 1.8 1 0 0 1 1 1 1 Bromodomain Lsr2 PF11774.8 EMC78943.1 - 8.6 6.6 11.2 0.42 10.8 1.0 2.5 2 0 0 2 2 2 0 Lsr2 Abhydrolase_1 PF00561.20 EMC78944.1 - 1.2e-23 84.1 0.0 2.8e-21 76.3 0.0 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMC78944.1 - 7.3e-19 69.3 0.0 9.3e-19 68.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMC78944.1 - 1e-10 41.3 0.0 3e-08 33.2 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Ndr PF03096.14 EMC78944.1 - 0.00024 19.9 0.0 0.0045 15.7 0.0 2.0 2 0 0 2 2 2 1 Ndr family PGAP1 PF07819.13 EMC78944.1 - 0.0089 15.8 0.0 0.02 14.6 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.25 EMC78944.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) BTB PF00651.31 EMC78945.1 - 3.6e-23 81.9 0.0 2.4e-21 76.0 0.0 2.0 1 1 1 2 2 2 2 BTB/POZ domain SPOB_ab PF14682.6 EMC78945.1 - 0.036 14.1 0.0 0.059 13.4 0.0 1.3 1 0 0 1 1 1 0 Sporulation initiation phospho-transferase B, C-terminal BTB_3 PF16017.5 EMC78945.1 - 0.13 12.4 0.1 0.35 11.0 0.0 1.7 2 0 0 2 2 2 0 BTB/POZ domain DUF4596 PF15363.6 EMC78946.1 - 1.3e-27 95.7 5.9 1.3e-27 95.7 5.9 3.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4596) DUF4580 PF15162.6 EMC78947.1 - 1.4e-59 200.3 0.7 1.7e-59 200.1 0.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4580) Kinetochor_Ybp2 PF08568.10 EMC78948.1 - 6e-90 302.5 20.9 7.3e-90 302.3 20.9 1.1 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin Colipase-like PF15083.6 EMC78948.1 - 0.019 15.1 2.6 0.051 13.7 1.4 2.4 2 0 0 2 2 2 0 Colipase-like zf-AD PF07776.15 EMC78948.1 - 0.023 14.9 1.9 0.031 14.5 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger associated domain (zf-AD) RPAP2_Rtr1 PF04181.13 EMC78949.1 - 7.1e-24 83.9 5.1 2.5e-23 82.2 5.1 2.0 1 0 0 1 1 1 1 Rtr1/RPAP2 family Peptidase_M27 PF01742.17 EMC78949.1 - 0.0094 15.1 0.1 0.016 14.3 0.1 1.3 1 0 0 1 1 1 1 Clostridial neurotoxin zinc protease MetOD2 PF18548.1 EMC78949.1 - 0.072 13.2 0.2 18 5.5 0.0 3.3 2 0 0 2 2 2 0 Metanogen output domain 2 zf-C2H2 PF00096.26 EMC78950.1 - 3.7e-29 99.5 48.2 8e-06 26.0 1.0 6.8 7 0 0 7 7 6 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC78950.1 - 2.9e-27 93.8 41.9 1.4e-06 28.5 2.0 7.2 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC78950.1 - 9.2e-23 79.0 41.6 0.00073 20.2 0.8 6.7 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC78950.1 - 3.5e-15 55.6 39.1 0.0026 17.7 2.8 6.5 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC78950.1 - 3.8e-15 55.7 15.4 0.0079 16.5 0.0 6.4 6 0 0 6 6 6 6 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC78950.1 - 2.4e-07 30.9 26.1 0.01 16.2 0.3 5.8 6 0 0 6 6 6 3 Zinc-finger of C2H2 type Ta0938 PF11494.8 EMC78950.1 - 6.6e-05 23.1 1.6 0.03 14.6 0.0 2.8 2 1 1 3 3 3 1 Ta0938 zf-BED PF02892.15 EMC78950.1 - 0.00073 19.5 29.2 0.31 11.1 5.4 5.7 4 1 2 6 6 6 2 BED zinc finger zf_UBZ PF18439.1 EMC78950.1 - 0.0016 18.0 17.3 6.5 6.4 0.1 6.1 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger zf-Di19 PF05605.12 EMC78950.1 - 0.0022 18.3 21.8 0.15 12.4 3.6 4.4 3 1 1 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-CHCC PF10276.9 EMC78950.1 - 0.0079 16.2 10.2 0.46 10.6 0.3 4.6 4 0 0 4 4 4 2 Zinc-finger domain zf-C2H2_3rep PF18868.1 EMC78950.1 - 0.0089 16.7 20.0 0.68 10.6 2.2 4.9 1 1 1 2 2 2 1 Zinc finger C2H2-type, 3 repeats zf_C2H2_ZHX PF18387.1 EMC78950.1 - 0.025 14.2 1.5 0.025 14.2 1.5 3.5 3 2 1 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain Prok-RING_1 PF14446.6 EMC78950.1 - 0.05 13.5 15.9 9 6.3 0.1 5.9 6 0 0 6 6 6 0 Prokaryotic RING finger family 1 FYVE PF01363.21 EMC78950.1 - 0.059 13.5 25.9 1.6 8.9 9.3 4.0 1 1 3 4 4 4 0 FYVE zinc finger GAGA PF09237.11 EMC78950.1 - 0.075 12.9 6.7 6.5 6.6 0.0 4.2 2 2 2 4 4 4 0 GAGA factor BolA PF01722.18 EMC78950.1 - 0.14 12.4 7.2 0.95 9.8 0.5 3.4 2 2 1 3 3 3 0 BolA-like protein HypA PF01155.19 EMC78950.1 - 0.16 12.0 11.3 1.8 8.6 1.6 3.4 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_11 PF16622.5 EMC78950.1 - 0.18 11.6 29.8 4.9 7.0 0.2 6.3 6 0 0 6 6 6 0 zinc-finger C2H2-type HNH_5 PF14279.6 EMC78950.1 - 0.18 11.7 17.7 3.7 7.5 0.8 5.8 6 1 0 6 6 5 0 HNH endonuclease Zn-ribbon_8 PF09723.10 EMC78950.1 - 0.23 11.6 26.7 1.5 9.0 3.2 5.7 4 2 2 6 6 6 0 Zinc ribbon domain zinc_ribbon_15 PF17032.5 EMC78950.1 - 0.25 12.1 14.1 3.6 8.4 1.6 3.7 2 1 2 4 4 3 0 zinc-ribbon family zf-C2HC_2 PF13913.6 EMC78950.1 - 0.25 11.3 25.5 1.7 8.6 1.0 6.0 6 0 0 6 6 6 0 zinc-finger of a C2HC-type PyrI_C PF02748.15 EMC78950.1 - 0.59 10.1 13.9 1.6 8.7 0.1 5.2 5 1 1 6 6 6 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf_ZIC PF18366.1 EMC78950.1 - 0.72 10.0 18.4 2.5 8.3 0.1 5.2 3 1 3 6 6 6 0 Zic proteins zinc finger domain XPA_N PF01286.18 EMC78950.1 - 1.5 9.0 23.6 7.9 6.6 0.1 6.7 7 0 0 7 7 7 0 XPA protein N-terminal Ribosomal_S27e PF01667.17 EMC78950.1 - 2.1 8.1 10.4 1.4 8.7 0.1 4.5 4 1 1 5 5 5 0 Ribosomal protein S27 zf-C2H2_2 PF12756.7 EMC78950.1 - 2.4 8.5 23.8 35 4.8 0.5 5.6 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) Zf_RING PF16744.5 EMC78950.1 - 2.5 8.3 17.8 14 5.9 0.6 5.5 1 1 5 6 6 6 0 KIAA1045 RING finger zf-AN1 PF01428.16 EMC78950.1 - 3.8 7.7 34.0 5.2 7.3 0.7 6.8 5 2 2 7 7 7 0 AN1-like Zinc finger Arc_trans_TRASH PF08394.10 EMC78950.1 - 4.2 7.8 8.8 56 4.2 0.1 4.7 3 2 0 3 3 3 0 Archaeal TRASH domain ADK_lid PF05191.14 EMC78950.1 - 5.9 7.0 15.3 21 5.2 4.6 4.7 3 2 1 4 4 4 0 Adenylate kinase, active site lid RabGAP-TBC PF00566.18 EMC78951.1 - 2.2e-53 181.1 2.0 2.2e-53 181.1 2.0 2.2 3 0 0 3 3 3 1 Rab-GTPase-TBC domain DUF1129 PF06570.11 EMC78951.1 - 0.087 12.3 0.2 0.087 12.3 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) PARP_reg PF02877.14 EMC78951.1 - 0.14 12.2 8.3 0.13 12.4 0.8 2.9 2 0 0 2 2 2 0 Poly(ADP-ribose) polymerase, regulatory domain Surfac_D-trimer PF09006.11 EMC78951.1 - 0.94 9.4 7.2 10 6.1 0.2 4.1 4 0 0 4 4 4 0 Lung surfactant protein D coiled-coil trimerisation Ribosomal_L5e PF17144.4 EMC78952.1 - 9.8e-95 315.1 1.0 2e-94 314.1 1.0 1.5 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 EMC78952.1 - 1.1e-39 135.3 9.7 1.1e-39 135.3 9.7 1.7 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region DUF1476 PF07345.11 EMC78952.1 - 0.0099 16.2 0.2 0.023 15.0 0.2 1.7 1 0 0 1 1 1 1 ATPase inhibitor subunit zeta PIP49_C PF12260.8 EMC78953.1 - 6.9e-57 192.2 0.1 1.1e-56 191.5 0.1 1.3 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 PIP49_N PF14875.6 EMC78953.1 - 2.8e-36 124.8 2.1 7.7e-36 123.3 0.0 2.1 2 0 0 2 2 2 1 N-term cysteine-rich ER, FAM69 EF-hand_5 PF13202.6 EMC78953.1 - 0.15 11.6 0.0 0.36 10.4 0.0 1.5 1 0 0 1 1 1 0 EF hand Mtf2_C PF14061.6 EMC78954.1 - 3.3e-27 94.4 0.1 6.3e-27 93.5 0.1 1.5 1 0 0 1 1 1 1 Polycomb-like MTF2 factor 2 PHD PF00628.29 EMC78954.1 - 8.1e-17 60.9 27.7 1.9e-12 46.9 8.0 2.5 2 0 0 2 2 2 2 PHD-finger Tudor_2 PF18104.1 EMC78954.1 - 3.3e-13 49.1 0.0 7.5e-13 47.9 0.0 1.7 1 0 0 1 1 1 1 Jumonji domain-containing protein 2A Tudor domain Prok-RING_1 PF14446.6 EMC78954.1 - 0.00014 21.7 3.3 0.00014 21.7 3.3 2.9 3 0 0 3 3 2 1 Prokaryotic RING finger family 1 DUF4537 PF15057.6 EMC78954.1 - 0.0017 18.4 0.0 0.004 17.2 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) DUF1325 PF07039.11 EMC78954.1 - 0.0046 17.0 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 SGF29 tudor-like domain DUF3682 PF12446.8 EMC78954.1 - 0.009 16.5 2.1 0.018 15.5 2.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3682) C1_1 PF00130.22 EMC78954.1 - 0.01 15.7 1.2 0.01 15.7 1.2 3.0 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF3573 PF12097.8 EMC78954.1 - 0.075 11.8 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Chromo PF00385.24 EMC78954.1 - 0.12 12.3 0.3 0.36 10.8 0.0 2.1 2 0 0 2 2 2 0 Chromo (CHRromatin Organisation MOdifier) domain PHD_3 PF13922.6 EMC78954.1 - 3.3 8.2 9.3 2.1 8.8 0.3 2.8 2 0 0 2 2 2 0 PHD domain of transcriptional enhancer, Asx EMP24_GP25L PF01105.24 EMC78955.1 - 3.1e-27 95.7 0.1 3.4e-27 95.5 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF1664 PF07889.12 EMC78956.1 - 0.013 15.5 8.4 0.013 15.5 8.4 10.2 4 1 4 10 10 10 0 Protein of unknown function (DUF1664) adh_short PF00106.25 EMC78957.1 - 1.2e-36 126.1 0.0 4.2e-36 124.2 0.0 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC78957.1 - 2.6e-23 82.8 0.0 9.5e-23 81.0 0.0 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC78957.1 - 2.9e-08 33.8 0.0 4.3e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EMC78957.1 - 0.0017 17.8 0.0 0.0031 17.0 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Eno-Rase_NADH_b PF12242.8 EMC78957.1 - 0.0029 17.3 0.0 0.055 13.2 0.0 2.2 2 0 0 2 2 2 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase CBFD_NFYB_HMF PF00808.23 EMC78958.1 - 2.5e-23 82.1 2.5 3.9e-23 81.5 0.8 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EMC78958.1 - 4.7e-05 23.8 0.0 9.9e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-W PF15510.6 EMC78958.1 - 0.00058 20.0 0.6 0.0011 19.1 0.1 1.6 2 0 0 2 2 2 1 CENP-W protein AAA_32 PF13654.6 EMC78958.1 - 0.019 13.8 0.0 0.03 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain RexA PF15969.5 EMC78958.1 - 0.033 13.7 0.0 0.039 13.5 0.0 1.1 1 0 0 1 1 1 0 Intracellular sensor of Lambda phage, Abi component Bromo_TP PF07524.13 EMC78958.1 - 0.099 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated SH2 PF00017.24 EMC78959.1 - 2.7e-15 56.2 0.0 6.6e-15 55.0 0.0 1.7 1 0 0 1 1 1 1 SH2 domain RasGEF PF00617.19 EMC78959.1 - 4e-12 46.7 0.0 8.3e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 RasGEF domain Fcf2 PF08698.11 EMC78960.1 - 9.1e-39 131.8 0.5 9.1e-39 131.8 0.5 2.9 3 1 0 3 3 3 1 Fcf2 pre-rRNA processing DUF4706 PF15797.5 EMC78960.1 - 0.85 10.2 6.7 1.5 9.4 0.3 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4706) Aldo_ket_red PF00248.21 EMC78961.1 - 7e-06 25.5 0.0 8.3e-06 25.2 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Steroid_dh PF02544.16 EMC78962.1 - 1.3e-26 93.4 5.5 2.4e-26 92.5 5.5 1.5 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase RhoGAP PF00620.27 EMC78963.1 - 1.1e-49 168.1 0.5 1.1e-49 168.1 0.5 2.3 2 0 0 2 2 2 1 RhoGAP domain C1_1 PF00130.22 EMC78963.1 - 1.1e-06 28.5 9.4 2.4e-06 27.3 9.4 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING-like PF08746.11 EMC78963.1 - 1.5 9.2 9.6 3.4 8.1 9.6 1.6 1 0 0 1 1 1 0 RING-like domain Exonuc_VII_L PF02601.15 EMC78963.1 - 5 6.6 12.4 12 5.4 12.4 1.6 1 0 0 1 1 1 0 Exonuclease VII, large subunit BPL_N PF09825.9 EMC78963.1 - 7.5 5.5 8.7 17 4.4 8.7 1.5 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal ABC_membrane_2 PF06472.15 EMC78964.1 - 9.2e-98 326.9 6.0 1.2e-97 326.5 6.0 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EMC78964.1 - 1e-17 64.9 0.0 2.2e-17 63.9 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 EMC78964.1 - 0.00073 20.1 0.0 0.0016 18.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 EMC78964.1 - 0.0013 18.2 0.0 0.21 11.0 0.0 2.3 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EMC78964.1 - 0.011 15.6 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EMC78964.1 - 0.017 14.8 0.0 0.037 13.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 EMC78964.1 - 0.029 14.3 0.0 0.069 13.1 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_27 PF13514.6 EMC78964.1 - 0.038 13.6 0.0 0.12 11.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain Lon_2 PF13337.6 EMC78964.1 - 0.077 11.5 0.0 0.14 10.6 0.0 1.4 1 0 0 1 1 1 0 Putative ATP-dependent Lon protease AAA_18 PF13238.6 EMC78964.1 - 0.15 12.6 0.0 0.36 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EMC78964.1 - 0.16 11.7 0.0 0.34 10.6 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_16 PF13191.6 EMC78964.1 - 0.16 12.3 0.0 0.32 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Interfer-bind PF09294.10 EMC78965.1 - 3.9e-20 72.1 1.4 3.9e-19 68.9 0.1 2.1 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III Tissue_fac PF01108.17 EMC78965.1 - 3.1e-18 65.6 1.5 3.5e-18 65.4 0.4 1.6 2 0 0 2 2 2 1 Tissue factor TMEM154 PF15102.6 EMC78965.1 - 0.02 14.8 0.5 0.032 14.2 0.0 1.6 2 0 0 2 2 2 0 TMEM154 protein family Sarcoglycan_2 PF05510.13 EMC78965.1 - 0.074 11.8 0.6 0.14 10.9 0.3 1.6 1 1 1 2 2 2 0 Sarcoglycan alpha/epsilon Orf78 PF06024.12 EMC78965.1 - 0.15 12.4 1.2 0.29 11.5 1.2 1.6 1 1 0 1 1 1 0 Orf78 (ac78) EphA2_TM PF14575.6 EMC78965.1 - 0.2 12.6 0.7 0.78 10.7 0.7 2.0 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF5104 PF17117.5 EMC78965.1 - 0.86 10.1 4.3 0.51 10.8 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5104) Choline_transpo PF04515.12 EMC78966.1 - 5.6e-91 305.1 35.5 5.6e-91 305.1 35.5 2.6 2 1 1 3 3 3 1 Plasma-membrane choline transporter Ski_Sno PF02437.17 EMC78966.1 - 0.081 12.7 0.5 0.22 11.3 0.5 1.7 1 0 0 1 1 1 0 SKI/SNO/DAC family DUF3671 PF12420.8 EMC78966.1 - 1.4 9.0 6.3 10 6.2 6.3 2.5 1 1 0 1 1 1 0 Protein of unknown function Calponin PF00402.18 EMC78968.1 - 1.9e-44 148.9 16.5 4.8e-16 58.1 1.5 3.5 3 0 0 3 3 3 3 Calponin family repeat CH PF00307.31 EMC78968.1 - 8.8e-23 80.6 0.1 1.3e-22 80.0 0.1 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain Raf1_HTH PF18579.1 EMC78968.1 - 0.14 11.8 0.0 0.52 10.0 0.0 2.0 2 0 0 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain CAMSAP_CH PF11971.8 EMC78968.1 - 0.18 11.7 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 CAMSAP CH domain Alg14 PF08660.11 EMC78969.1 - 7.3e-66 221.4 0.1 8.3e-66 221.2 0.1 1.0 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like Retrotrans_gag PF03732.17 EMC78969.1 - 0.12 12.7 0.1 0.18 12.1 0.1 1.3 1 0 0 1 1 1 0 Retrotransposon gag protein TRAM_LAG1_CLN8 PF03798.16 EMC78970.1 - 1.2e-35 123.1 16.6 1.2e-35 123.1 16.6 1.5 2 0 0 2 2 2 1 TLC domain Cyto_heme_lyase PF01265.17 EMC78971.1 - 2.9e-71 240.4 20.7 5.6e-70 236.2 20.7 2.5 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase DUF1115 PF06544.12 EMC78972.1 - 2.1e-07 31.2 1.1 4.7e-05 23.5 1.1 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1115) NICE-3 PF07406.11 EMC78972.1 - 0.049 13.6 0.1 0.062 13.3 0.1 1.2 1 0 0 1 1 1 0 NICE-3 protein BLUF PF04940.12 EMC78972.1 - 0.065 13.4 0.1 0.29 11.3 0.1 1.9 1 1 1 2 2 2 0 Sensors of blue-light using FAD DHO_dh PF01180.21 EMC78973.1 - 5.2e-35 121.1 0.0 4.5e-34 118.0 0.0 2.2 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase Fer4_21 PF14697.6 EMC78973.1 - 4.3e-24 84.4 12.1 4.3e-24 84.4 12.1 3.1 3 0 0 3 3 3 1 4Fe-4S dicluster domain Pyr_redox_2 PF07992.14 EMC78973.1 - 1.2e-13 50.9 0.0 4.8e-13 49.0 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 EMC78973.1 - 9.6e-13 47.9 0.0 9.6e-13 47.9 0.0 2.5 3 0 0 3 3 2 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster NAD_binding_8 PF13450.6 EMC78973.1 - 2.8e-08 33.9 0.0 7.7e-08 32.5 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Dus PF01207.17 EMC78973.1 - 1.5e-06 27.6 0.0 1.3e-05 24.4 0.0 2.1 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) Pyr_redox_3 PF13738.6 EMC78973.1 - 3.7e-06 26.4 0.0 0.032 13.5 0.0 2.6 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Fer4_7 PF12838.7 EMC78973.1 - 1.8e-05 25.2 10.2 1.8e-05 25.2 10.2 2.5 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4 PF00037.27 EMC78973.1 - 2.2e-05 24.0 20.8 0.0063 16.3 4.6 3.9 3 0 0 3 3 3 2 4Fe-4S binding domain Pyr_redox PF00070.27 EMC78973.1 - 4.8e-05 23.8 0.0 0.64 10.6 0.0 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Fer4_10 PF13237.6 EMC78973.1 - 0.0002 21.4 11.2 0.0002 21.4 11.2 2.4 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 EMC78973.1 - 0.00032 20.6 1.8 0.00032 20.6 1.8 3.6 3 1 1 4 4 3 2 4Fe-4S binding domain Fer4_2 PF12797.7 EMC78973.1 - 0.0013 18.7 13.5 0.0027 17.7 2.3 3.8 4 0 0 4 4 3 2 4Fe-4S binding domain Fer4_9 PF13187.6 EMC78973.1 - 0.0018 18.4 11.9 0.0018 18.4 11.9 2.1 2 0 0 2 2 1 1 4Fe-4S dicluster domain Thi4 PF01946.17 EMC78973.1 - 0.032 13.5 0.0 0.073 12.3 0.0 1.5 1 0 0 1 1 1 0 Thi4 family Fer4_13 PF13370.6 EMC78973.1 - 0.073 13.6 13.8 0.72 10.4 3.3 2.8 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I DAO PF01266.24 EMC78973.1 - 0.12 11.9 0.0 0.38 10.3 0.0 1.8 1 1 0 1 1 1 0 FAD dependent oxidoreductase Shikimate_DH PF01488.20 EMC78973.1 - 0.16 12.0 0.0 28 4.7 0.0 2.7 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase MCRA PF06100.11 EMC78973.1 - 0.26 10.0 0.0 0.5 9.1 0.0 1.4 1 0 0 1 1 1 0 MCRA family Fer4_17 PF13534.6 EMC78973.1 - 3.8 8.1 17.7 0.23 12.0 0.9 3.1 3 0 0 3 3 2 0 4Fe-4S dicluster domain Fer4_4 PF12800.7 EMC78973.1 - 8.6 7.1 24.6 0.27 11.8 3.0 3.3 3 0 0 3 3 2 0 4Fe-4S binding domain PX PF00787.24 EMC78974.1 - 3.5e-26 91.4 0.8 6.6e-26 90.5 0.8 1.4 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 EMC78974.1 - 3.1e-05 23.6 3.6 0.0035 16.9 0.7 2.5 2 1 0 2 2 2 1 Vps5 C terminal like NuA4 PF09340.10 EMC78974.1 - 0.07 13.0 1.3 0.16 11.9 0.1 2.2 2 1 0 2 2 2 0 Histone acetyltransferase subunit NuA4 PAP2 PF01569.21 EMC78975.1 - 3e-22 78.9 2.9 4e-22 78.5 2.9 1.2 1 0 0 1 1 1 1 PAP2 superfamily Cyt_bd_oxida_II PF02322.15 EMC78975.1 - 0.023 14.1 0.4 0.035 13.5 0.4 1.2 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit II Tim17 PF02466.19 EMC78975.1 - 0.097 13.1 0.2 0.16 12.4 0.2 1.4 1 0 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family MtrF PF09472.10 EMC78975.1 - 0.19 11.1 0.8 0.41 10.1 0.8 1.6 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) PAP2 PF01569.21 EMC78976.1 - 2.5e-17 62.9 1.3 3.9e-17 62.3 1.3 1.3 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 EMC78976.1 - 0.072 12.8 0.3 0.12 12.0 0.3 1.4 1 0 0 1 1 1 0 PAP2 superfamily Paralemmin PF03285.15 EMC78977.1 - 3.2e-55 187.9 20.5 3.7e-54 184.4 20.3 2.3 1 1 0 1 1 1 1 Paralemmin Mu-like_Pro PF10123.9 EMC78977.1 - 0.093 12.3 8.5 0.19 11.3 8.5 1.4 1 0 0 1 1 1 0 Mu-like prophage I protein ERM PF00769.19 EMC78977.1 - 0.098 12.5 26.7 0.025 14.4 21.0 2.3 2 0 0 2 2 2 0 Ezrin/radixin/moesin family FlaC_arch PF05377.11 EMC78977.1 - 1.7 9.1 6.2 12 6.4 6.2 2.5 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) Syntaxin-6_N PF09177.11 EMC78977.1 - 1.9 9.1 9.4 7 7.3 9.4 2.0 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Nup54 PF13874.6 EMC78977.1 - 9.6 6.3 17.8 1.9 8.6 13.6 2.0 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Reeler PF02014.16 EMC78978.1 - 7.5e-30 104.3 0.0 1.2e-29 103.7 0.0 1.3 1 0 0 1 1 1 1 Reeler domain DOMON PF03351.17 EMC78978.1 - 2.2e-20 73.1 0.0 3.9e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 DOMON domain Cytochrom_B561 PF03188.16 EMC78978.1 - 2.7e-05 24.3 11.1 2.7e-05 24.3 11.1 1.6 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 Claudin_3 PF06653.11 EMC78978.1 - 0.046 13.7 5.5 0.076 13.0 4.6 1.8 1 1 0 1 1 1 0 Tight junction protein, Claudin-like Nuc_sug_transp PF04142.15 EMC78979.1 - 2.7e-128 427.5 16.6 3.6e-128 427.2 16.6 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 EMC78979.1 - 8.8e-06 25.9 22.8 3.2e-05 24.1 1.7 2.5 3 0 0 3 3 3 2 EamA-like transporter family EmrE PF13536.6 EMC78979.1 - 0.09 12.3 8.2 0.19 11.3 1.1 2.3 2 0 0 2 2 2 0 Putative multidrug resistance efflux transporter Aim19 PF10315.9 EMC78979.1 - 0.092 13.0 1.9 0.62 10.4 0.1 2.5 1 1 0 2 2 2 0 Altered inheritance of mitochondria protein 19 PUNUT PF16913.5 EMC78979.1 - 0.42 9.8 14.5 0.013 14.7 5.2 2.5 2 1 1 3 3 3 0 Purine nucleobase transmembrane transport UAA PF08449.11 EMC78979.1 - 2 7.6 13.2 0.33 10.1 2.8 2.4 2 0 0 2 2 2 0 UAA transporter family MFS_1 PF07690.16 EMC78980.1 - 8.1e-34 117.1 37.4 2.1e-32 112.4 37.9 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EMC78980.1 - 1.3e-11 44.0 21.9 1.2e-09 37.5 21.9 2.9 1 1 0 1 1 1 1 MFS_1 like family CCB1 PF12046.8 EMC78980.1 - 1.8 7.9 4.4 1.4 8.2 1.3 2.3 2 0 0 2 2 2 0 Cofactor assembly of complex C subunit B SAS-6_N PF16531.5 EMC78981.1 - 3.5e-28 98.0 1.5 3.5e-28 98.0 1.5 2.3 2 0 0 2 2 2 1 Centriolar protein SAS N-terminal Sas6_CC PF18594.1 EMC78981.1 - 6e-14 51.5 7.3 6e-14 51.5 7.3 4.3 5 0 0 5 5 5 1 Sas6/XLF/XRCC4 coiled-coil domain Tropomyosin_1 PF12718.7 EMC78981.1 - 0.011 15.9 14.3 0.011 15.9 14.3 4.9 1 1 4 5 5 5 0 Tropomyosin like DUF641 PF04859.12 EMC78981.1 - 0.019 15.3 6.6 0.019 15.3 6.6 5.4 1 1 3 4 4 4 0 Plant protein of unknown function (DUF641) Spc7 PF08317.11 EMC78981.1 - 0.21 10.4 79.4 1.1 8.1 27.2 3.1 1 1 2 3 3 3 0 Spc7 kinetochore protein PI3K_P85_iSH2 PF16454.5 EMC78981.1 - 2.9 7.5 65.2 0.12 11.9 22.8 4.1 1 1 3 4 4 4 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain ATG16 PF08614.11 EMC78981.1 - 6.4 7.0 76.7 0.051 13.8 10.3 4.5 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) DUF1192 PF06698.11 EMC78981.1 - 9.3 6.4 13.4 17 5.6 0.2 5.0 4 0 0 4 4 4 0 Protein of unknown function (DUF1192) TRM13 PF05206.14 EMC78982.1 - 3.3e-85 285.8 2.1 4.9e-85 285.2 2.1 1.3 1 0 0 1 1 1 1 Methyltransferase TRM13 zf-TRM13_CCCH PF11722.8 EMC78982.1 - 4.9e-13 48.6 3.4 4.9e-13 48.6 3.4 2.5 2 0 0 2 2 2 1 CCCH zinc finger in TRM13 protein zf-U11-48K PF05253.12 EMC78982.1 - 5.4e-11 42.2 1.3 1.2e-10 41.0 1.3 1.6 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger LRR_8 PF13855.6 EMC78983.1 - 2.3e-28 97.8 16.9 2.9e-09 36.6 0.5 3.6 2 1 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EMC78983.1 - 3.6e-26 90.8 32.9 6.1e-07 29.7 2.5 5.5 2 1 4 6 6 6 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC78983.1 - 8.5e-07 28.7 17.7 7.9 7.5 0.0 8.5 8 0 0 8 8 8 2 Leucine Rich Repeat LRR_9 PF14580.6 EMC78983.1 - 1.7e-06 27.6 12.6 0.0029 17.1 1.5 3.1 1 1 3 4 4 4 2 Leucine-rich repeat LRR_6 PF13516.6 EMC78983.1 - 1.2 9.4 18.9 29 5.0 0.1 6.8 7 0 0 7 7 7 0 Leucine Rich repeat CREPT PF16566.5 EMC78983.1 - 2 8.6 9.3 5.8 7.1 0.0 4.3 1 1 4 5 5 5 0 Cell-cycle alteration and expression-elevated protein in tumour 2-oxoacid_dh PF00198.23 EMC78984.1 - 9.7e-80 267.3 0.0 1.4e-79 266.8 0.0 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EMC78984.1 - 1.5e-20 72.8 0.1 2.7e-20 72.0 0.1 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EMC78984.1 - 1.7e-14 53.8 0.0 3.8e-14 52.7 0.0 1.6 1 0 0 1 1 1 1 e3 binding domain Toprim_Crpt PF13342.6 EMC78984.1 - 0.099 12.6 0.1 0.88 9.6 0.0 2.3 2 0 0 2 2 2 0 C-terminal repeat of topoisomerase Biotin_lipoyl_2 PF13533.6 EMC78984.1 - 0.15 11.9 0.0 3 7.8 0.0 2.3 1 1 1 2 2 2 0 Biotin-lipoyl like Ig_3 PF13927.6 EMC78985.1 - 8.2e-52 173.7 8.9 1.6e-13 51.0 0.2 5.3 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 EMC78985.1 - 1.4e-48 162.9 4.1 3e-15 56.0 0.3 5.0 4 1 0 4 4 4 4 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC78985.1 - 1.5e-41 140.6 7.6 6.6e-11 42.4 0.0 5.2 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 EMC78985.1 - 8.6e-36 122.0 5.5 2.7e-10 40.3 0.1 5.2 5 0 0 5 5 5 4 Immunoglobulin domain V-set PF07686.17 EMC78985.1 - 1.9e-17 63.4 15.0 0.0018 18.4 0.0 9.0 5 4 3 9 9 9 4 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC78985.1 - 6.9e-14 51.7 6.1 0.1 12.7 0.0 5.7 5 1 0 5 5 5 4 CD80-like C2-set immunoglobulin domain C2-set PF05790.15 EMC78985.1 - 2.1e-12 47.1 5.5 3e-09 37.0 0.0 4.3 5 0 0 5 5 5 2 Immunoglobulin C2-set domain Ig_4 PF16680.5 EMC78985.1 - 3.7e-06 27.1 3.7 0.07 13.4 0.1 4.4 4 1 0 4 4 4 2 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 EMC78985.1 - 1.7e-05 24.2 0.2 1.1 8.8 0.0 4.6 4 1 0 4 4 4 1 Immunoglobulin domain Ig_C17orf99 PF17736.1 EMC78985.1 - 4.8e-05 23.3 6.1 0.11 12.5 0.0 4.8 4 1 0 4 4 3 2 C17orf99 Ig domain DUF2808 PF10989.8 EMC78985.1 - 0.00043 20.3 1.1 1.3 9.0 0.3 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF2808) Izumo-Ig PF16706.5 EMC78985.1 - 0.00099 19.1 0.3 8.2 6.6 0.0 4.0 4 1 0 4 4 4 1 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.8 EMC78985.1 - 0.0062 16.7 0.5 3 8.1 0.0 3.3 3 1 1 4 4 3 1 Natural killer cell receptor 2B4 C1-set PF07654.15 EMC78985.1 - 0.0075 16.6 2.2 1.9 8.9 0.0 4.6 5 0 0 5 5 5 1 Immunoglobulin C1-set domain V-set_CD47 PF08204.11 EMC78985.1 - 0.0084 16.1 0.3 3.7 7.6 0.1 3.6 3 0 0 3 3 3 1 CD47 immunoglobulin-like domain Herpes_gE PF02480.16 EMC78985.1 - 0.01 14.7 1.8 0.046 12.5 0.0 2.3 3 0 0 3 3 3 0 Alphaherpesvirus glycoprotein E DUF824 PF05688.11 EMC78985.1 - 0.2 11.5 0.4 2.5 8.0 0.3 2.5 2 0 0 2 2 2 0 Salmonella repeat of unknown function (DUF824) MAGUK_N_PEST PF10608.9 EMC78985.1 - 2 8.9 9.1 63 4.0 7.8 3.1 1 1 1 2 2 2 0 Polyubiquitination (PEST) N-terminal domain of MAGUK DSPn PF14671.6 EMC78986.1 - 2.8e-61 206.1 3.1 4.9e-61 205.3 1.8 2.1 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 EMC78986.1 - 1.4e-14 54.0 0.1 5.6e-14 52.1 0.0 2.1 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EMC78986.1 - 2.3e-06 27.8 0.0 4.9e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 EMC78986.1 - 6.9e-05 22.5 0.0 0.00011 21.8 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EMC78986.1 - 0.011 15.7 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Glyco_transf_64 PF09258.10 EMC78987.1 - 2.1e-87 292.5 0.0 2.6e-87 292.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Glyco_tranf_2_3 PF13641.6 EMC78987.1 - 0.0009 19.2 0.0 0.0013 18.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EMC78987.1 - 0.0072 16.1 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 TP_methylase PF00590.20 EMC78988.1 - 2.6e-23 83.1 0.0 5.5e-23 82.0 0.0 1.5 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF4062 PF13271.6 EMC78988.1 - 0.15 12.5 0.0 0.32 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4062) Aldo_ket_red PF00248.21 EMC78989.1 - 6.8e-56 189.6 0.0 3.1e-53 180.9 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family 7tm_1 PF00001.21 EMC78990.1 - 7.2e-40 137.0 20.0 7.2e-40 137.0 20.0 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC78990.1 - 4e-05 23.1 23.4 5.3e-05 22.7 23.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 EMC78990.1 - 4.1e-05 23.1 14.6 4.1e-05 23.1 14.6 2.1 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 EMC78990.1 - 0.0007 19.4 20.7 0.0022 17.8 20.7 2.0 1 1 0 1 1 1 1 Olfactory receptor DUF2208 PF09973.9 EMC78990.1 - 0.035 13.7 0.5 0.035 13.7 0.5 2.5 2 2 1 3 3 3 0 Predicted membrane protein (DUF2208) OLF PF02191.16 EMC78991.1 - 1.2e-83 280.5 7.1 1.7e-83 280.0 7.1 1.2 1 0 0 1 1 1 1 Olfactomedin-like domain Noelin-1 PF12308.8 EMC78991.1 - 3e-41 139.5 5.3 6.5e-41 138.4 2.3 2.6 2 1 2 4 4 4 1 Neurogenesis glycoprotein CLZ PF16526.5 EMC78991.1 - 1.2 9.6 4.5 8.5 6.8 0.4 2.6 2 1 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels C_Hendra PF16821.5 EMC78991.1 - 1.3 8.9 6.7 4.5 7.1 0.5 2.8 3 0 0 3 3 3 0 C protein from hendra and measles viruses RRM_1 PF00076.22 EMC78992.1 - 5e-10 39.0 0.3 1.6e-06 27.8 0.3 3.4 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Alpha-amylase_C PF02806.18 EMC78993.1 - 1.9e-14 53.9 0.2 4.4e-14 52.7 0.2 1.7 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 EMC78993.1 - 1.6e-13 50.9 0.0 3.5e-13 49.8 0.0 1.5 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Alpha-amylase_C PF02806.18 EMC78994.1 - 4.4e-17 62.3 0.1 9.6e-17 61.2 0.1 1.6 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 EMC78994.1 - 6.3e-15 55.6 0.0 9.1e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Laminin_N PF00055.17 EMC78995.1 - 2e-55 187.9 0.0 2e-55 187.9 0.0 2.9 3 1 1 4 4 4 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.24 EMC78995.1 - 2.2e-20 72.5 70.4 2e-08 34.2 11.4 5.0 4 1 1 5 5 5 3 Laminin EGF domain EGF_2 PF07974.13 EMC78995.1 - 0.0023 18.2 10.1 0.0023 18.2 10.1 7.5 6 2 0 6 6 6 1 EGF-like domain hEGF PF12661.7 EMC78995.1 - 0.0045 17.6 8.2 0.0045 17.6 8.2 7.0 7 1 1 8 8 8 1 Human growth factor-like EGF EGF PF00008.27 EMC78995.1 - 0.0072 16.6 9.3 0.0072 16.6 9.3 6.2 5 2 0 5 5 5 1 EGF-like domain RhoGEF PF00621.20 EMC78996.1 - 8e-39 133.8 7.9 8e-39 133.8 7.9 1.8 2 0 0 2 2 2 1 RhoGEF domain SH3_2 PF07653.17 EMC78996.1 - 4.1e-23 80.8 0.0 3.8e-14 52.1 0.0 2.9 2 0 0 2 2 2 2 Variant SH3 domain SH3_9 PF14604.6 EMC78996.1 - 3.9e-18 65.0 0.1 2.1e-11 43.5 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 EMC78996.1 - 1.9e-17 62.6 0.1 1.2e-13 50.4 0.0 2.5 2 0 0 2 2 2 2 SH3 domain SH2 PF00017.24 EMC78996.1 - 1.8e-15 56.8 0.5 8.7e-15 54.6 0.5 2.2 1 0 0 1 1 1 1 SH2 domain C1_1 PF00130.22 EMC78996.1 - 2.9e-09 36.7 4.8 5.7e-09 35.7 4.8 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.29 EMC78996.1 - 8.7e-08 32.6 0.1 2.3e-07 31.3 0.1 1.7 1 0 0 1 1 1 1 PH domain CH PF00307.31 EMC78996.1 - 3e-06 27.4 0.1 1.8e-05 24.9 0.0 2.4 2 0 0 2 2 2 1 Calponin homology (CH) domain Filamin PF00630.19 EMC78996.1 - 0.00053 20.8 0.1 0.0027 18.5 0.1 2.2 1 1 0 1 1 1 1 Filamin/ABP280 repeat Prok-RING_1 PF14446.6 EMC78996.1 - 0.006 16.5 1.8 0.016 15.1 1.8 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 CAMSAP_CH PF11971.8 EMC78996.1 - 0.016 15.1 1.2 0.045 13.6 0.1 2.4 2 0 0 2 2 2 0 CAMSAP CH domain LZ3wCH PF18517.1 EMC78996.1 - 0.02 15.0 0.2 0.02 15.0 0.2 2.9 3 0 0 3 3 2 0 Leucine zipper with capping helix domain DUF2326 PF10088.9 EMC78996.1 - 0.025 14.3 0.2 5.2 6.8 0.1 2.5 2 0 0 2 2 2 0 Uncharacterised protein conserved in bacteria (DUF2326) C1_2 PF03107.16 EMC78996.1 - 0.027 14.8 3.2 0.066 13.5 3.2 1.7 1 0 0 1 1 1 0 C1 domain Zn_ribbon_17 PF17120.5 EMC78996.1 - 0.051 13.2 1.0 0.14 11.8 1.0 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type PH_10 PF15411.6 EMC78996.1 - 0.089 13.1 2.3 0.15 12.3 0.1 2.5 3 0 0 3 3 3 0 Pleckstrin homology domain PHD PF00628.29 EMC78996.1 - 1 9.3 3.5 2.8 7.9 3.5 1.7 1 0 0 1 1 1 0 PHD-finger Methyltransf_12 PF08242.12 EMC78997.1 - 0.0044 17.7 0.0 0.0097 16.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC78997.1 - 0.034 14.0 0.0 0.074 12.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 EMC78997.1 - 0.045 14.5 0.0 0.15 12.8 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain fn3 PF00041.21 EMC78998.1 - 1.1e-32 112.2 4.5 1.2e-05 25.6 0.2 9.9 9 2 0 9 9 9 5 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 EMC78998.1 - 1.7e-05 25.3 7.5 5.1 7.7 0.1 6.7 5 3 1 6 6 6 2 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 EMC78998.1 - 1.7e-05 25.1 8.5 0.0043 17.4 0.0 4.6 6 0 0 6 6 6 2 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.10 EMC78998.1 - 0.0057 17.0 2.2 25 5.3 0.0 4.8 6 0 0 6 6 6 1 Interferon-alpha/beta receptor, fibronectin type III Y_Y_Y PF07495.13 EMC78998.1 - 0.011 15.6 0.0 1 9.4 0.0 3.8 5 0 0 5 5 5 0 Y_Y_Y domain Salt_tol_Pase PF09506.10 EMC78998.1 - 0.25 10.0 0.0 0.41 9.4 0.0 1.2 1 0 0 1 1 1 0 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase) Sec1 PF00995.23 EMC78999.1 - 1.6e-121 407.3 5.2 1.8e-121 407.2 5.2 1.0 1 0 0 1 1 1 1 Sec1 family PDZ_3 PF17815.1 EMC78999.1 - 0.078 12.8 0.1 0.18 11.6 0.1 1.7 1 0 0 1 1 1 0 PDZ domain DUF2621 PF11084.8 EMC78999.1 - 0.11 12.4 0.1 0.29 11.1 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2621) GoLoco PF02188.17 EMC79000.1 - 3.1e-39 131.9 28.2 2.2e-10 39.8 3.6 4.5 4 0 0 4 4 4 4 GoLoco motif TPR_12 PF13424.6 EMC79000.1 - 7.8e-38 128.6 26.8 1.5e-10 41.2 4.5 5.6 3 2 3 7 7 6 6 Tetratricopeptide repeat TPR_1 PF00515.28 EMC79000.1 - 4.1e-36 121.3 29.3 1e-06 28.3 0.4 8.1 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_7 PF13176.6 EMC79000.1 - 1.7e-31 105.9 20.7 8.6e-06 25.4 0.2 8.5 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 EMC79000.1 - 7e-20 69.5 30.0 0.00033 20.5 0.6 8.2 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 EMC79000.1 - 1.4e-19 68.6 22.2 0.00032 20.7 0.3 7.9 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_10 PF13374.6 EMC79000.1 - 3.8e-18 64.7 24.4 0.0004 20.2 0.4 8.3 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_4 PF07721.14 EMC79000.1 - 3.6e-08 33.3 0.1 0.48 11.2 0.2 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMC79000.1 - 4.6e-06 27.0 4.9 3.8 8.6 0.1 6.2 5 1 1 6 6 5 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EMC79000.1 - 7.9e-06 25.5 5.5 0.013 14.9 3.3 2.8 2 1 0 2 2 2 2 MalT-like TPR region TPR_16 PF13432.6 EMC79000.1 - 1.7e-05 25.4 11.6 0.028 15.0 0.3 6.1 4 1 1 5 5 5 1 Tetratricopeptide repeat Rapsyn_N PF10579.9 EMC79000.1 - 2.3e-05 24.4 1.1 9.5 6.4 0.1 5.2 3 2 2 5 5 5 1 Rapsyn N-terminal myristoylation and linker region TPR_11 PF13414.6 EMC79000.1 - 0.00029 20.4 21.9 0.28 10.9 0.2 7.4 6 2 1 7 7 7 2 TPR repeat TPR_6 PF13174.6 EMC79000.1 - 0.015 15.9 5.7 21 6.1 0.2 6.0 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 EMC79000.1 - 0.019 15.3 15.6 21 5.8 0.1 7.1 7 0 0 7 7 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC79000.1 - 0.051 13.8 12.3 3.3 8.0 2.6 5.1 3 1 2 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.9 EMC79000.1 - 0.4 10.4 2.5 1.7 8.3 0.1 2.8 3 2 0 3 3 3 0 26S proteasome subunit RPN7 MCLC PF05934.11 EMC79001.1 - 1.4e-173 578.5 6.0 1.6e-173 578.4 6.0 1.0 1 0 0 1 1 1 1 Mid-1-related chloride channel (MCLC) PAP2 PF01569.21 EMC79001.1 - 9.1 6.1 10.1 3.5 7.4 5.6 2.1 2 0 0 2 2 2 0 PAP2 superfamily WD40 PF00400.32 EMC79002.1 - 5.9e-28 96.5 15.1 2.8e-05 24.8 0.0 7.6 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC79002.1 - 5.2e-13 49.1 0.0 8e-05 22.9 0.0 4.8 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain LisH_TPL PF17814.1 EMC79002.1 - 4.6e-09 35.8 1.4 2.4e-08 33.5 0.0 2.4 2 0 0 2 2 2 1 LisH-like dimerisation domain Vir_act_alpha_C PF10400.9 EMC79002.1 - 0.19 12.5 5.4 0.44 11.3 5.4 1.6 1 0 0 1 1 1 0 Virulence activator alpha C-term DUF4798 PF16055.5 EMC79002.1 - 0.94 9.8 4.3 14 6.0 1.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4798) DEAD PF00270.29 EMC79003.1 - 2.2e-43 148.0 2.2 2.5e-43 147.9 0.7 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC79003.1 - 2.3e-21 76.2 0.0 1.1e-19 70.8 0.0 3.0 2 1 1 3 3 3 1 Helicase conserved C-terminal domain zf-HIT PF04438.16 EMC79003.1 - 4.9e-08 32.7 1.8 8.5e-08 31.9 1.8 1.4 1 0 0 1 1 1 1 HIT zinc finger SecA_DEAD PF07517.14 EMC79003.1 - 0.0091 15.3 0.2 0.28 10.4 0.0 2.4 2 0 0 2 2 2 1 SecA DEAD-like domain UvrD-helicase PF00580.21 EMC79003.1 - 0.04 13.4 0.8 1.2 8.6 0.0 2.3 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA PF00004.29 EMC79003.1 - 0.054 13.9 0.5 0.19 12.1 0.2 2.2 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) CMS1 PF14617.6 EMC79003.1 - 0.092 12.1 0.1 0.092 12.1 0.1 2.0 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Toprim_C_rpt PF13368.6 EMC79003.1 - 0.11 12.5 0.0 0.29 11.1 0.0 1.7 1 0 0 1 1 1 0 Topoisomerase C-terminal repeat AMP-binding PF00501.28 EMC79003.1 - 0.17 10.4 0.0 1.3 7.6 0.0 2.1 2 0 0 2 2 2 0 AMP-binding enzyme Kinesin PF00225.23 EMC79004.1 - 1.1e-106 356.6 0.1 1.1e-106 356.6 0.1 2.1 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EMC79004.1 - 5e-25 88.2 0.0 5e-25 88.2 0.0 2.8 2 0 0 2 2 2 1 Microtubule binding Kinesin_assoc PF16183.5 EMC79004.1 - 1.1e-13 51.8 7.3 9.7e-12 45.4 1.0 4.5 3 2 1 4 4 4 2 Kinesin-associated FHA PF00498.26 EMC79004.1 - 7.9e-09 35.8 0.1 2.1e-08 34.4 0.1 1.8 1 0 0 1 1 1 1 FHA domain KIF1B PF12423.8 EMC79004.1 - 0.043 14.3 1.9 0.075 13.5 0.1 2.5 2 0 0 2 2 2 0 Kinesin protein 1B Yop-YscD_cpl PF16697.5 EMC79004.1 - 0.062 13.6 0.0 0.26 11.6 0.0 2.1 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain Caps_synth_GfcC PF06251.11 EMC79004.1 - 1.2 8.7 11.5 4.4 6.9 0.1 3.0 2 0 0 2 2 2 0 Capsule biosynthesis GfcC zf-H2C2_2 PF13465.6 EMC79005.1 - 2.1e-19 69.0 20.9 1.5e-06 28.4 0.2 4.7 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2 PF00096.26 EMC79005.1 - 5.5e-12 45.4 33.4 0.0025 18.2 0.8 4.9 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC79005.1 - 1e-06 29.0 42.5 0.01 16.6 4.1 5.3 5 0 0 5 5 5 4 C2H2-type zinc finger FYVE PF01363.21 EMC79005.1 - 4.2e-06 26.8 0.4 0.12 12.6 0.0 3.1 1 1 1 2 2 2 1 FYVE zinc finger DZR PF12773.7 EMC79005.1 - 1.5 8.9 8.0 6.6 6.8 2.0 2.6 2 0 0 2 2 2 0 Double zinc ribbon GAGA PF09237.11 EMC79005.1 - 1.6 8.6 9.7 0.18 11.6 1.9 2.9 1 1 1 3 3 3 0 GAGA factor XPA_N PF01286.18 EMC79005.1 - 2.2 8.4 9.0 9.8 6.3 0.0 4.3 4 0 0 4 4 4 0 XPA protein N-terminal zf-C2H2_jaz PF12171.8 EMC79005.1 - 3.8 7.9 16.8 2.9 8.3 0.3 4.6 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-MYST PF17772.1 EMC79005.1 - 6 6.6 12.8 0.61 9.7 1.8 3.1 2 1 1 3 3 3 0 MYST family zinc finger domain zf-C4 PF00105.18 EMC79006.1 - 2.7e-32 111.0 12.0 4.6e-32 110.3 12.0 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 EMC79006.1 - 7.6e-31 107.3 5.9 1.3e-30 106.6 5.9 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor DUF2431 PF10354.9 EMC79006.1 - 0.13 12.5 0.0 0.34 11.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) Y_phosphatase PF00102.27 EMC79007.1 - 1.3e-74 250.7 0.8 2.1e-74 250.0 0.8 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EMC79007.1 - 0.0051 16.8 0.0 0.0071 16.3 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EMC79008.1 - 2e-78 263.2 0.0 3e-78 262.6 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EMC79008.1 - 0.0087 16.2 0.0 0.14 12.3 0.0 2.4 2 0 0 2 2 2 1 Inositol hexakisphosphate DSPc PF00782.20 EMC79008.1 - 0.0093 15.8 0.0 0.022 14.6 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC79008.1 - 0.0095 15.9 0.0 0.016 15.2 0.0 1.5 1 1 0 1 1 1 1 Tyrosine phosphatase family V-ATPase_G PF03179.15 EMC79009.1 - 2.3e-28 98.8 9.1 2.7e-28 98.5 9.1 1.1 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit FdhE PF04216.12 EMC79009.1 - 0.01 15.7 1.4 0.012 15.6 1.4 1.0 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation CENP-Q PF13094.6 EMC79009.1 - 0.033 14.4 3.9 0.041 14.1 3.9 1.1 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Atg14 PF10186.9 EMC79009.1 - 0.065 12.3 7.7 0.072 12.2 7.7 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FAM75 PF14650.6 EMC79009.1 - 0.12 11.9 3.4 0.13 11.8 3.4 1.1 1 0 0 1 1 1 0 FAM75 family Prominin PF05478.11 EMC79009.1 - 0.13 10.1 3.2 0.16 9.9 3.2 1.0 1 0 0 1 1 1 0 Prominin RabGAP-TBC PF00566.18 EMC79009.1 - 0.2 11.3 1.7 0.26 10.9 1.7 1.3 1 1 0 1 1 1 0 Rab-GTPase-TBC domain GED PF02212.18 EMC79009.1 - 0.3 11.3 4.5 5.2 7.3 0.1 2.2 2 0 0 2 2 2 0 Dynamin GTPase effector domain DUF3552 PF12072.8 EMC79009.1 - 0.51 9.7 11.6 1.2 8.5 11.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) Muted PF14942.6 EMC79009.1 - 0.52 10.7 9.1 0.96 9.8 8.8 1.6 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein EMC3_TMCO1 PF01956.16 EMC79009.1 - 1.2 8.8 4.5 1.6 8.4 4.5 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Pkinase PF00069.25 EMC79010.1 - 1.5e-65 221.2 0.0 1.9e-65 220.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC79010.1 - 4.6e-48 163.7 0.0 5.7e-48 163.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC79010.1 - 5.3e-06 26.0 0.0 8.4e-06 25.3 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EMC79010.1 - 1.7e-05 24.0 0.0 3.1e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EMC79010.1 - 0.00026 19.9 0.0 0.00033 19.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase PIP49_C PF12260.8 EMC79010.1 - 0.0039 16.9 0.3 0.22 11.1 0.1 2.2 2 0 0 2 2 2 1 Protein-kinase domain of FAM69 Kdo PF06293.14 EMC79010.1 - 0.0051 16.2 0.1 0.0082 15.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF309 PF03745.14 EMC79010.1 - 0.12 12.0 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF309) Gln_deamidase_2 PF18626.1 EMC79010.1 - 0.14 12.4 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 Glutaminase APH PF01636.23 EMC79010.1 - 0.16 11.9 0.0 0.58 10.0 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family LIM PF00412.22 EMC79011.1 - 5.6e-32 109.8 21.5 2.7e-16 59.5 4.0 2.3 2 0 0 2 2 2 2 LIM domain Homeodomain PF00046.29 EMC79011.1 - 5.1e-19 67.9 3.7 1.1e-18 66.8 3.7 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC79011.1 - 0.00014 21.7 5.1 0.00091 19.1 5.1 2.3 1 1 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 EMC79011.1 - 0.0061 16.0 0.0 0.015 14.7 0.0 1.6 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez TNFR_c6 PF00020.18 EMC79011.1 - 5.4 7.5 15.8 7.7 7.0 0.6 3.5 3 0 0 3 3 3 0 TNFR/NGFR cysteine-rich region DENN PF02141.21 EMC79012.1 - 1.7e-48 165.0 3.6 2.8e-48 164.4 3.6 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.19 EMC79012.1 - 2.2e-09 37.2 1.4 5.7e-09 35.8 1.4 1.8 1 0 0 1 1 1 1 dDENN domain EGF PF00008.27 EMC79013.1 - 2.8e-96 315.3 270.8 9.3e-08 32.2 4.0 19.4 18 1 0 18 18 18 17 EGF-like domain Laminin_G_2 PF02210.24 EMC79013.1 - 3.6e-52 176.2 1.1 2.2e-21 76.7 0.0 3.3 3 0 0 3 3 3 3 Laminin G domain hEGF PF12661.7 EMC79013.1 - 9e-52 172.0 223.3 7.2e-06 26.4 3.0 21.0 20 0 0 20 20 20 17 Human growth factor-like EGF Laminin_G_1 PF00054.23 EMC79013.1 - 1.7e-39 135.0 0.1 2.6e-15 56.8 0.0 3.4 3 0 0 3 3 3 3 Laminin G domain EGF_CA PF07645.15 EMC79013.1 - 2.2e-20 72.6 257.5 1.6e-05 25.0 5.6 19.7 16 3 4 20 20 20 12 Calcium-binding EGF domain EGF_2 PF07974.13 EMC79013.1 - 4.1e-12 46.2 295.6 0.03 14.7 8.5 19.1 18 1 0 18 18 18 14 EGF-like domain Laminin_G_3 PF13385.6 EMC79013.1 - 1.2e-06 28.8 0.0 0.0063 16.7 0.0 3.2 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily cEGF PF12662.7 EMC79013.1 - 0.00043 20.2 15.8 0.0022 17.9 2.7 17.5 18 0 0 18 18 18 10 Complement Clr-like EGF-like zf-H2C2_2 PF13465.6 EMC79014.1 - 9.9e-47 155.4 124.3 1.9e-06 28.0 2.3 15.6 16 0 0 16 16 16 13 Zinc-finger double domain zf-C2H2 PF00096.26 EMC79014.1 - 2.1e-46 153.9 134.6 0.00013 22.2 1.3 14.8 14 0 0 14 14 14 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC79014.1 - 2.9e-35 117.9 129.1 0.0051 17.5 2.8 14.8 14 0 0 14 14 14 14 C2H2-type zinc finger BTB PF00651.31 EMC79014.1 - 3.4e-21 75.6 0.5 1e-20 74.0 0.5 1.9 1 0 0 1 1 1 1 BTB/POZ domain zf-met PF12874.7 EMC79014.1 - 1.5e-09 37.9 85.2 0.00053 20.3 1.1 13.9 14 0 0 14 14 14 5 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EMC79014.1 - 7e-09 35.5 116.8 0.02 14.9 2.9 13.7 14 0 0 14 14 14 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC79014.1 - 1.1e-05 25.5 87.6 0.042 14.1 2.1 13.7 14 0 0 14 14 14 5 Zinc-finger double-stranded RNA-binding Thioredoxin_2 PF13098.6 EMC79014.1 - 0.0033 17.9 1.0 0.019 15.4 1.0 2.4 1 0 0 1 1 1 1 Thioredoxin-like domain GAGA PF09237.11 EMC79014.1 - 0.014 15.2 15.7 5 7.0 0.1 6.4 3 2 3 6 6 6 0 GAGA factor zf-C2H2_2 PF12756.7 EMC79014.1 - 0.054 13.8 82.5 0.056 13.8 4.1 13.0 3 1 7 11 11 11 0 C2H2 type zinc-finger (2 copies) zf-C2HC_2 PF13913.6 EMC79014.1 - 0.091 12.7 0.2 0.074 13.0 1.9 12.3 15 0 0 15 15 14 0 zinc-finger of a C2HC-type SDA1 PF05285.12 EMC79014.1 - 0.13 11.6 17.2 0.28 10.6 17.2 1.5 1 0 0 1 1 1 0 SDA1 BolA PF01722.18 EMC79014.1 - 0.37 11.1 9.5 19 5.6 0.1 5.1 3 2 2 5 5 5 0 BolA-like protein Sushi PF00084.20 EMC79015.1 - 2.9e-51 171.9 62.8 9e-09 35.8 3.5 9.4 9 0 0 9 9 9 8 Sushi repeat (SCR repeat) Sushi_2 PF09014.10 EMC79015.1 - 0.00033 20.5 1.7 0.0061 16.4 0.2 5.9 5 3 1 6 6 6 2 Beta-2-glycoprotein-1 fifth domain Galactosyl_T PF01762.21 EMC79016.1 - 9.9e-66 221.3 0.0 1.4e-65 220.8 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase Glutaredoxin PF00462.24 EMC79017.1 - 5e-20 71.5 0.0 6.4e-20 71.1 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.6 EMC79017.1 - 0.00011 22.2 0.1 0.00015 21.8 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin domain DUF836 PF05768.14 EMC79017.1 - 0.00094 19.6 0.0 0.0012 19.2 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_2 PF13098.6 EMC79017.1 - 0.0023 18.4 0.1 0.0031 18.0 0.1 1.3 1 1 0 1 1 1 1 Thioredoxin-like domain DSBA PF01323.20 EMC79017.1 - 0.01 15.6 0.5 0.24 11.2 0.1 2.1 1 1 1 2 2 2 0 DSBA-like thioredoxin domain DUF2117 PF09890.9 EMC79017.1 - 0.052 13.0 0.0 0.057 12.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2117) DUF2153 PF09921.9 EMC79017.1 - 0.074 12.9 0.0 1.3 8.8 0.0 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2153) TraF PF13728.6 EMC79017.1 - 0.097 12.5 0.1 0.11 12.3 0.1 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_4 PF13462.6 EMC79017.1 - 0.3 11.2 1.9 10 6.2 1.1 2.1 1 1 1 2 2 2 0 Thioredoxin TROVE PF05731.11 EMC79018.1 - 1.3e-50 172.8 0.6 8.6e-47 160.2 1.0 2.2 1 1 1 2 2 2 2 TROVE domain DUF2201 PF09967.9 EMC79018.1 - 0.003 17.7 1.1 0.0053 16.9 0.3 1.8 2 0 0 2 2 2 1 VWA-like domain (DUF2201) VWA_2 PF13519.6 EMC79018.1 - 0.084 13.5 0.1 0.21 12.3 0.1 1.7 1 0 0 1 1 1 0 von Willebrand factor type A domain Peptidase_C12 PF01088.21 EMC79019.1 - 1e-60 205.1 0.4 1.9e-60 204.2 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 EMC79019.1 - 4.6e-20 71.3 4.8 4.6e-20 71.3 4.8 2.5 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolases BBP1_C PF15272.6 EMC79019.1 - 0.0056 16.5 3.8 0.0056 16.5 3.8 2.0 1 1 1 2 2 2 1 Spindle pole body component BBP1, C-terminal DUF2785 PF10978.8 EMC79019.1 - 0.069 12.9 2.3 0.14 11.9 2.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2785) Exonuc_VII_L PF02601.15 EMC79019.1 - 5.7 6.4 8.6 2.8 7.4 5.9 1.7 2 0 0 2 2 2 0 Exonuclease VII, large subunit RGS PF00615.19 EMC79020.1 - 1e-39 135.4 7.4 1e-39 135.4 7.4 1.5 2 0 0 2 2 2 1 Regulator of G protein signaling domain COMPASS-Shg1 PF05205.12 EMC79020.1 - 0.035 14.8 0.3 0.073 13.8 0.3 1.5 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component shg1 RhoGEF67_u2 PF16614.5 EMC79020.1 - 0.076 13.1 0.4 0.19 11.8 0.4 1.6 1 0 0 1 1 1 0 Unstructured region two on RhoGEF 6 and 7 RGS PF00615.19 EMC79021.1 - 3.3e-34 117.7 1.8 3.8e-34 117.5 1.8 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.11 EMC79021.1 - 0.024 14.3 0.1 0.028 14.2 0.1 1.1 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain RGS PF00615.19 EMC79022.1 - 3.2e-37 127.4 3.0 4.8e-37 126.8 3.0 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.11 EMC79022.1 - 0.019 14.7 0.1 0.031 14.0 0.1 1.3 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain Nipped-B_C PF12830.7 EMC79022.1 - 0.085 12.8 0.8 0.13 12.2 0.2 1.6 2 0 0 2 2 2 0 Sister chromatid cohesion C-terminus RGS PF00615.19 EMC79023.1 - 7.2e-39 132.7 2.2 8.6e-39 132.5 2.2 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain TGT PF01702.18 EMC79023.1 - 0.062 12.5 0.1 0.07 12.3 0.1 1.1 1 0 0 1 1 1 0 Queuine tRNA-ribosyltransferase RGS PF00615.19 EMC79024.1 - 2.2e-38 131.1 3.3 3.1e-38 130.6 3.3 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.11 EMC79024.1 - 0.0021 17.8 0.0 0.0029 17.3 0.0 1.2 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain COMPASS-Shg1 PF05205.12 EMC79024.1 - 0.041 14.6 0.1 0.084 13.6 0.1 1.4 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component shg1 RGS PF00615.19 EMC79025.1 - 7.1e-37 126.3 1.6 9.4e-37 125.9 1.6 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain Sas6_CC PF18594.1 EMC79025.1 - 0.065 13.0 0.2 0.15 11.9 0.2 1.6 1 0 0 1 1 1 0 Sas6/XLF/XRCC4 coiled-coil domain RGS PF00615.19 EMC79026.1 - 3.8e-38 130.4 2.3 5e-38 130.0 2.3 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF4929 PF16283.5 EMC79026.1 - 0.051 12.6 0.1 0.063 12.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4929) RGS-like PF09128.11 EMC79026.1 - 0.066 12.9 0.1 0.087 12.5 0.1 1.1 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain Gag_p19 PF02228.16 EMC79026.1 - 0.1 13.0 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 Major core protein p19 PI-PLC-X PF00388.19 EMC79027.1 - 0.00043 19.9 0.0 0.0011 18.6 0.0 1.5 1 1 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain Sushi PF00084.20 EMC79028.1 - 1.8e-82 271.8 85.2 3.1e-10 40.5 4.2 10.0 9 1 1 10 10 10 9 Sushi repeat (SCR repeat) Lectin_C PF00059.21 EMC79028.1 - 1.4e-23 83.6 6.1 1.4e-23 83.6 6.1 3.6 4 0 0 4 4 4 1 Lectin C-type domain EGF_2 PF07974.13 EMC79028.1 - 3.7e-05 24.0 10.3 0.0016 18.7 10.3 4.3 1 0 0 1 1 1 1 EGF-like domain cEGF PF12662.7 EMC79028.1 - 0.00029 20.7 57.8 0.03 14.3 3.5 10.4 10 0 0 10 10 10 5 Complement Clr-like EGF-like EGF PF00008.27 EMC79028.1 - 0.00058 20.1 10.3 0.00058 20.1 10.3 5.3 4 0 0 4 4 4 1 EGF-like domain EGF_3 PF12947.7 EMC79028.1 - 0.014 15.6 2.2 0.014 15.6 2.2 6.4 7 1 0 7 7 7 0 EGF domain hEGF PF12661.7 EMC79028.1 - 0.018 15.7 4.4 0.018 15.7 4.4 4.9 4 0 0 4 4 4 0 Human growth factor-like EGF HRM PF02793.22 EMC79028.1 - 0.043 14.1 73.4 0.73 10.2 1.4 10.0 9 1 1 10 10 10 0 Hormone receptor domain bZIP_1 PF00170.21 EMC79029.1 - 7.9e-10 38.7 14.5 1.7e-09 37.6 14.5 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMC79029.1 - 3.5e-05 23.8 12.9 3.5e-05 23.8 12.9 2.2 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 EMC79029.1 - 0.0027 18.2 8.5 0.0027 18.2 8.5 2.8 3 0 0 3 3 3 1 bZIP Maf transcription factor MCU PF04678.13 EMC79029.1 - 0.27 11.3 1.5 0.65 10.1 0.1 2.0 2 0 0 2 2 2 0 Mitochondrial calcium uniporter YabA PF06156.13 EMC79029.1 - 4.7 7.9 6.5 2.4 8.9 3.0 2.1 2 0 0 2 2 2 0 Initiation control protein YabA OLF PF02191.16 EMC79030.1 - 3.3e-85 285.6 10.9 4.5e-85 285.2 10.9 1.2 1 0 0 1 1 1 1 Olfactomedin-like domain Noelin-1 PF12308.8 EMC79030.1 - 0.0023 17.8 0.7 0.015 15.3 0.0 2.3 2 0 0 2 2 2 1 Neurogenesis glycoprotein adh_short PF00106.25 EMC79031.1 - 3e-09 36.6 0.0 1.8e-07 30.8 0.0 3.1 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC79031.1 - 0.00027 20.6 0.0 0.012 15.1 0.0 2.5 2 1 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Pkinase_Tyr PF07714.17 EMC79032.1 - 5e-84 281.6 0.0 6.6e-84 281.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC79032.1 - 1.3e-42 146.0 0.0 1e-40 139.8 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 EMC79032.1 - 0.021 13.8 0.0 0.047 12.6 0.0 1.5 1 0 0 1 1 1 0 Haspin like kinase domain Shisa PF13908.6 EMC79032.1 - 0.062 13.6 0.1 0.13 12.5 0.0 1.4 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF4834 PF16118.5 EMC79032.1 - 0.13 13.2 0.0 0.24 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF3328 PF11807.8 EMC79032.1 - 0.24 11.2 0.8 0.48 10.2 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) F5_F8_type_C PF00754.25 EMC79033.1 - 3.1e-14 53.2 0.0 3.6e-14 53.0 0.0 1.0 1 0 0 1 1 1 1 F5/8 type C domain UDPGP PF01704.18 EMC79034.1 - 3.5e-65 220.3 0.0 1.5e-64 218.2 0.0 1.7 1 1 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Pkinase PF00069.25 EMC79035.1 - 2.4e-33 115.6 0.0 3e-33 115.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC79035.1 - 9.3e-17 61.2 0.1 1.3e-16 60.7 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RRM_1 PF00076.22 EMC79035.1 - 3.7e-08 33.1 0.0 7.1e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Kinase-like PF14531.6 EMC79035.1 - 1.4e-07 31.2 0.0 1.9e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC79035.1 - 0.00048 19.5 0.1 0.00076 18.9 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMC79035.1 - 0.0011 19.0 0.1 0.0017 18.3 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 EMC79035.1 - 0.0026 17.4 0.0 0.0047 16.6 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 EMC79035.1 - 0.073 12.7 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Spt46 PF17734.1 EMC79036.1 - 3.2e-25 89.3 1.4 3.4e-25 89.2 1.4 1.0 1 0 0 1 1 1 1 Spermatogenesis-associated protein 46 zf-C2H2_4 PF13894.6 EMC79036.1 - 0.083 13.8 2.1 0.083 13.8 2.1 1.9 2 0 0 2 2 2 0 C2H2-type zinc finger S_100 PF01023.19 EMC79036.1 - 0.13 12.0 0.1 0.18 11.5 0.1 1.3 1 0 0 1 1 1 0 S-100/ICaBP type calcium binding domain PID PF00640.23 EMC79037.1 - 9.5e-29 100.2 0.8 9.5e-29 100.2 0.8 2.1 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) Phage_GPO PF05929.11 EMC79037.1 - 0.051 13.2 2.3 0.12 11.9 2.3 1.6 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase CECR6_TMEM121 PF14997.6 EMC79038.1 - 6.3e-60 202.4 11.5 1.2e-59 201.5 11.5 1.4 1 0 0 1 1 1 1 CECR6/TMEM121 family DUF5083 PF16890.5 EMC79038.1 - 9.5e-05 22.2 1.4 9.5e-05 22.2 1.4 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF5083) DUF4509 PF14970.6 EMC79039.1 - 6.6e-68 228.4 0.0 7.3e-68 228.2 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4509) LIM PF00412.22 EMC79040.1 - 1.4e-13 50.9 1.9 1.5e-13 50.8 1.9 1.1 1 0 0 1 1 1 1 LIM domain zf_UBZ PF18439.1 EMC79040.1 - 4.2 7.1 7.4 0.37 10.4 1.1 2.1 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger MTA_R1 PF17226.2 EMC79041.1 - 6e-38 128.9 5.6 1.5e-34 118.0 1.9 2.7 2 0 0 2 2 2 2 MTA R1 domain BAH PF01426.18 EMC79041.1 - 6.6e-31 106.7 2.2 6.2e-30 103.6 1.1 2.4 2 1 0 2 2 2 1 BAH domain ELM2 PF01448.24 EMC79041.1 - 3.8e-13 50.0 0.4 1.5e-12 48.1 0.0 2.2 2 0 0 2 2 2 1 ELM2 domain GATA PF00320.27 EMC79041.1 - 9e-10 38.0 10.0 2.1e-09 36.8 10.0 1.7 1 0 0 1 1 1 1 GATA zinc finger Myb_DNA-binding PF00249.31 EMC79041.1 - 3.4e-05 23.9 0.0 9.1e-05 22.6 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EMC79041.1 - 0.017 15.0 2.1 0.019 14.8 0.1 2.1 2 0 0 2 2 2 0 Myb DNA-binding like Pacs-1 PF10254.9 EMC79042.1 - 4.9e-202 671.4 0.6 9.5e-202 670.4 0.6 1.5 1 0 0 1 1 1 1 PACS-1 cytosolic sorting protein Longin PF13774.6 EMC79043.1 - 2.2e-23 82.1 0.1 2.6e-23 81.9 0.1 1.1 1 0 0 1 1 1 1 Regulated-SNARE-like domain Lectin_C PF00059.21 EMC79045.1 - 1.1e-16 61.5 3.7 1.4e-16 61.2 3.7 1.1 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 EMC79045.1 - 0.011 15.4 0.9 0.019 14.6 0.9 1.7 1 1 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Cnd1 PF12717.7 EMC79047.1 - 0.0074 16.3 1.6 0.0074 16.3 1.6 2.8 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 AMPK1_CBM PF16561.5 EMC79048.1 - 3.7e-36 123.2 0.2 6.2e-36 122.5 0.2 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 EMC79048.1 - 8.5e-28 96.4 2.9 1.5e-27 95.6 2.9 1.4 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain CBM_48 PF02922.18 EMC79048.1 - 0.0027 18.0 0.0 0.0058 17.0 0.0 1.5 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) FMO-like PF00743.19 EMC79049.1 - 6.4e-253 840.0 0.0 7.9e-253 839.7 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EMC79049.1 - 6.7e-17 61.7 0.0 2.1e-12 46.9 0.0 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMC79049.1 - 1.9e-12 47.0 0.0 8.9e-10 38.3 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMC79049.1 - 2.5e-10 40.0 0.3 2e-07 30.5 0.0 3.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EMC79049.1 - 6.7e-06 26.2 0.4 0.55 10.2 0.1 4.3 3 1 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EMC79049.1 - 1.4e-05 25.2 0.1 0.00041 20.5 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMC79049.1 - 0.00014 21.6 1.3 4 6.9 0.0 4.0 4 0 0 4 4 4 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EMC79049.1 - 0.00028 21.4 1.2 0.0086 16.6 0.1 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMC79049.1 - 0.0063 15.3 0.5 1.8 7.2 0.2 2.3 2 0 0 2 2 2 2 HI0933-like protein Thi4 PF01946.17 EMC79049.1 - 0.0069 15.7 0.2 3.7 6.7 0.0 2.3 2 0 0 2 2 2 2 Thi4 family Shikimate_DH PF01488.20 EMC79049.1 - 0.093 12.8 0.1 1.4 9.0 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase GIDA PF01134.22 EMC79049.1 - 0.18 10.9 1.2 1.5 7.8 0.1 2.6 3 0 0 3 3 3 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EMC79049.1 - 0.62 9.1 3.5 11 4.9 0.1 2.6 3 0 0 3 3 3 0 FAD binding domain ESPR PF13018.6 EMC79049.1 - 0.92 9.4 4.4 13 5.7 0.6 3.3 3 0 0 3 3 3 0 Extended Signal Peptide of Type V secretion system FMO-like PF00743.19 EMC79050.1 - 4.5e-259 860.3 0.0 5e-259 860.1 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EMC79050.1 - 1e-18 67.7 0.0 7.7e-14 51.6 0.0 2.3 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMC79050.1 - 1.6e-14 53.9 0.0 2.3e-11 43.5 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMC79050.1 - 3.9e-10 39.4 0.2 4.6e-07 29.3 0.0 3.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EMC79050.1 - 2.3e-05 24.5 0.0 7.3e-05 22.9 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EMC79050.1 - 3.8e-05 23.7 0.9 0.13 12.3 0.2 3.9 3 1 0 3 3 3 1 FAD-NAD(P)-binding Thi4 PF01946.17 EMC79050.1 - 0.00033 20.0 0.2 0.23 10.7 0.1 2.3 2 0 0 2 2 2 2 Thi4 family DAO PF01266.24 EMC79050.1 - 0.00075 19.2 0.6 0.26 10.8 0.0 3.1 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EMC79050.1 - 0.0037 17.8 0.4 0.13 12.9 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 EMC79050.1 - 0.041 13.9 0.0 8.2 6.5 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.14 EMC79050.1 - 0.079 11.6 1.1 0.77 8.4 0.2 2.3 2 0 0 2 2 2 0 HI0933-like protein IlvN PF07991.12 EMC79050.1 - 0.091 12.3 0.1 4.1 7.0 0.0 2.5 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain 2-Hacid_dh_C PF02826.19 EMC79050.1 - 0.19 11.1 0.2 3.2 7.1 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GIDA PF01134.22 EMC79050.1 - 0.69 8.9 1.7 8.6 5.3 0.0 2.6 3 0 0 3 3 3 0 Glucose inhibited division protein A PAP2 PF01569.21 EMC79051.1 - 2.3e-19 69.5 5.0 3.8e-19 68.8 5.0 1.3 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 EMC79051.1 - 9.6e-07 28.7 10.7 3.4e-06 26.9 10.7 1.9 1 1 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.6 EMC79051.1 - 0.00096 19.6 3.8 0.00096 19.6 3.8 2.1 1 1 1 2 2 2 1 PAP2 superfamily C-terminal DUF5326 PF17260.2 EMC79051.1 - 0.17 12.0 6.1 7.9 6.7 0.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5326) RFC1 PF08519.12 EMC79052.1 - 0.051 13.7 0.0 0.063 13.4 0.0 1.2 1 0 0 1 1 1 0 Replication factor RFC1 C terminal domain AhpC-TSA PF00578.21 EMC79053.1 - 7e-20 71.2 0.0 1.1e-19 70.6 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.9 EMC79053.1 - 8e-13 48.0 0.3 1.6e-12 47.0 0.3 1.6 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.10 EMC79053.1 - 3.5e-07 30.0 0.0 4.2e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Redoxin SAGA-Tad1 PF12767.7 EMC79054.1 - 9.3e-28 97.6 0.3 2.6e-15 56.8 0.1 2.3 1 1 1 2 2 2 2 Transcriptional regulator of RNA polII, SAGA, subunit TAF4 PF05236.14 EMC79054.1 - 0.012 15.4 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family TNF PF00229.18 EMC79056.1 - 1.5e-32 112.2 0.1 2.1e-32 111.7 0.1 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family Sad1_UNC PF07738.13 EMC79057.1 - 3.7e-37 127.3 0.0 8.4e-37 126.1 0.0 1.7 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal dNK PF01712.19 EMC79057.1 - 0.0049 16.7 0.2 0.012 15.5 0.2 1.6 1 0 0 1 1 1 1 Deoxynucleoside kinase Trehalase PF01204.18 EMC79057.1 - 0.02 13.7 2.3 0.81 8.4 0.0 2.4 2 0 0 2 2 2 0 Trehalase DUF4658 PF15555.6 EMC79057.1 - 0.026 14.7 0.9 0.17 12.0 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4658) Tweety PF04906.13 EMC79057.1 - 0.035 12.8 3.7 0.059 12.0 3.7 1.2 1 0 0 1 1 1 0 Tweety Telomere_reg-2 PF10193.9 EMC79057.1 - 0.51 10.8 3.1 1.7 9.1 3.1 1.9 1 0 0 1 1 1 0 Telomere length regulation protein SlyX PF04102.12 EMC79057.1 - 3.7 8.2 11.3 3.5 8.3 3.7 3.0 1 1 1 2 2 2 0 SlyX Methyltransf_25 PF13649.6 EMC79058.1 - 3.6e-18 66.0 0.1 3.6e-12 46.8 0.1 2.9 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EMC79058.1 - 9e-18 64.7 0.1 3.6e-13 50.0 0.0 3.0 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 EMC79058.1 - 3.3e-17 62.7 0.0 1e-12 48.1 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Spermine_synth PF01564.17 EMC79058.1 - 3.1e-08 33.3 0.5 6.9e-07 28.8 0.0 2.3 2 1 0 2 2 2 1 Spermine/spermidine synthase domain Methyltransf_12 PF08242.12 EMC79058.1 - 1.1e-05 26.1 0.0 0.0057 17.4 0.0 2.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC79058.1 - 6.4e-05 22.9 0.0 0.098 12.5 0.0 3.0 2 1 0 2 2 2 2 Methyltransferase domain MTS PF05175.14 EMC79058.1 - 0.00045 19.8 0.0 0.21 11.1 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase small domain Ham1p_like PF01725.16 EMC79059.1 - 2.3e-47 161.3 0.0 2.6e-47 161.2 0.0 1.0 1 0 0 1 1 1 1 Ham1 family Synaptobrevin PF00957.21 EMC79060.1 - 1e-34 118.2 2.5 1.3e-34 117.8 2.5 1.2 1 0 0 1 1 1 1 Synaptobrevin MCU PF04678.13 EMC79060.1 - 0.00082 19.5 0.0 0.00088 19.4 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial calcium uniporter RIFIN PF02009.16 EMC79060.1 - 0.004 17.1 0.0 0.0041 17.1 0.0 1.1 1 0 0 1 1 1 1 Rifin Fzo_mitofusin PF04799.13 EMC79060.1 - 0.0072 15.9 0.7 0.011 15.3 0.7 1.3 1 0 0 1 1 1 1 fzo-like conserved region DUF5345 PF17280.2 EMC79060.1 - 0.0078 16.2 0.1 0.014 15.4 0.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5345) Ferlin_C PF16165.5 EMC79060.1 - 0.018 15.0 0.0 0.024 14.6 0.0 1.3 1 0 0 1 1 1 0 Ferlin C-terminus UPF0258 PF06789.12 EMC79060.1 - 0.11 12.6 0.8 0.19 11.9 0.8 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0258) XhlA PF10779.9 EMC79060.1 - 0.58 10.4 3.7 2.2 8.6 2.3 2.2 1 1 1 2 2 2 0 Haemolysin XhlA DUF948 PF06103.11 EMC79060.1 - 2.6 8.3 10.3 0.59 10.4 0.2 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 EMC79060.1 - 4.6 7.3 8.3 1.4 9.0 2.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) OLF PF02191.16 EMC79061.1 - 2.7e-83 279.4 0.0 3.1e-83 279.2 0.0 1.0 1 0 0 1 1 1 1 Olfactomedin-like domain FMO-like PF00743.19 EMC79062.1 - 1e-237 789.8 0.0 1.2e-237 789.6 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EMC79062.1 - 6.8e-16 58.4 0.0 1.5e-12 47.4 0.0 2.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMC79062.1 - 4.5e-12 45.8 0.0 2.2e-10 40.3 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMC79062.1 - 2.1e-08 33.7 0.0 1.5e-07 30.9 0.0 2.1 1 1 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EMC79062.1 - 9.7e-05 22.5 0.0 0.00023 21.3 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EMC79062.1 - 0.00021 21.3 0.1 0.0027 17.7 0.0 2.6 2 1 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EMC79062.1 - 0.003 18.1 0.1 1.1 9.9 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMC79062.1 - 0.0058 16.2 0.0 0.48 10.0 0.0 2.6 3 0 0 3 3 3 1 FAD dependent oxidoreductase FMO-like PF00743.19 EMC79063.1 - 4.3e-114 381.8 0.0 5e-114 381.6 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EMC79063.1 - 0.11 11.8 0.0 0.14 11.3 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMC79063.1 - 0.31 10.2 0.0 0.48 9.6 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EMC79064.1 - 6.7e-21 74.3 0.1 6.9e-21 74.3 0.1 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EMC79064.1 - 4.1e-07 30.1 0.0 4.6e-07 30.0 0.0 1.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EMC79064.1 - 0.00057 19.2 0.0 0.0006 19.1 0.0 1.0 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 EMC79064.1 - 0.00091 18.4 0.0 0.00091 18.4 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EMC79064.1 - 0.014 14.1 0.0 0.014 14.1 0.0 1.0 1 0 0 1 1 1 0 HI0933-like protein AlaDh_PNT_C PF01262.21 EMC79064.1 - 0.026 13.8 0.0 0.026 13.8 0.0 1.0 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 EMC79064.1 - 0.037 13.4 0.0 0.04 13.3 0.0 1.0 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMC79064.1 - 0.041 13.1 0.0 0.041 13.1 0.0 1.0 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EMC79064.1 - 0.086 12.7 0.1 0.091 12.6 0.1 1.0 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.27 EMC79064.1 - 0.13 12.8 0.0 0.14 12.7 0.0 1.0 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EMC79064.1 - 0.14 12.2 0.0 0.15 12.1 0.0 1.1 1 0 0 1 1 1 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 EMC79064.1 - 0.15 11.3 0.1 0.15 11.3 0.1 1.0 1 0 0 1 1 1 0 FAD binding domain Homeodomain PF00046.29 EMC79065.1 - 6.4e-23 80.4 6.4 1.5e-22 79.2 6.4 1.6 1 0 0 1 1 1 1 Homeodomain OAR PF03826.17 EMC79065.1 - 9e-08 31.7 0.1 1.6e-07 30.9 0.1 1.5 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.11 EMC79065.1 - 0.00096 19.0 0.2 0.0029 17.5 0.2 1.8 1 0 0 1 1 1 1 Homeobox KN domain Transcrip_act PF04949.13 EMC79066.1 - 2.3e-08 34.1 18.7 4.3e-08 33.2 18.7 1.4 1 0 0 1 1 1 1 Transcriptional activator DUF1828 PF08861.10 EMC79066.1 - 3 8.2 6.6 0.53 10.6 1.3 2.3 2 1 0 2 2 2 0 Domain of unknown function DUF1828 DUF2407_C PF13373.6 EMC79066.1 - 6.2 7.0 12.3 1.8 8.8 0.0 2.9 3 0 0 3 3 3 0 DUF2407 C-terminal domain Methyltransf_PK PF05891.12 EMC79067.1 - 2.1e-69 233.4 0.0 2.6e-69 233.1 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 EMC79067.1 - 5.5e-06 27.0 0.0 9.1e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC79067.1 - 0.00013 22.5 0.0 0.00021 21.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC79067.1 - 0.0011 19.6 0.0 0.0019 18.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 EMC79067.1 - 0.0028 17.0 0.0 0.0035 16.7 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain KAP PF05804.12 EMC79068.1 - 0 1280.1 27.1 0 1271.6 27.1 2.0 1 1 0 1 1 1 1 Kinesin-associated protein (KAP) Arm PF00514.23 EMC79068.1 - 0.00025 21.0 10.7 0.12 12.5 0.1 6.8 7 1 1 8 8 8 1 Armadillo/beta-catenin-like repeat RICTOR_M PF14666.6 EMC79068.1 - 0.0069 16.1 0.2 0.033 14.0 0.0 2.3 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, middle domain FPL PF09758.9 EMC79068.1 - 0.011 15.7 13.4 0.094 12.7 3.2 4.2 2 1 1 3 3 3 0 Uncharacterised conserved protein HEAT PF02985.22 EMC79068.1 - 0.095 13.0 0.8 7.4 7.1 0.0 4.1 4 0 0 4 4 4 0 HEAT repeat V-ATPase_H_C PF11698.8 EMC79068.1 - 0.84 9.8 8.0 2.4 8.3 0.1 4.0 3 1 0 3 3 3 0 V-ATPase subunit H Pkinase PF00069.25 EMC79069.1 - 1.7e-06 27.6 0.0 4.3e-05 23.0 0.0 2.4 1 1 0 1 1 1 1 Protein kinase domain NUC PF18510.1 EMC79070.1 - 0.056 13.9 0.1 0.075 13.5 0.1 1.1 1 0 0 1 1 1 0 Nuclease domain Peptidase_M16_M PF16187.5 EMC79071.1 - 6.5e-86 288.1 2.2 1e-85 287.4 2.2 1.3 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 EMC79071.1 - 2e-41 141.4 0.0 1.6e-40 138.5 0.0 2.4 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EMC79071.1 - 4.8e-37 127.7 1.7 1.5e-21 77.2 0.0 2.9 3 0 0 3 3 3 2 Peptidase M16 inactive domain SDA1 PF05285.12 EMC79071.1 - 0.12 11.8 17.0 0.2 11.1 17.0 1.3 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EMC79071.1 - 4.7 5.3 22.6 7.7 4.6 22.6 1.2 1 0 0 1 1 1 0 Nop14-like family Ras PF00071.22 EMC79072.1 - 5.4e-61 204.9 0.5 6.5e-61 204.7 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC79072.1 - 4e-34 117.4 0.6 5.7e-34 116.9 0.6 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC79072.1 - 5.2e-13 48.8 0.2 6.3e-13 48.5 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EMC79072.1 - 3.8e-05 23.2 0.0 0.00015 21.2 0.0 1.8 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EMC79072.1 - 0.00021 21.3 0.0 0.0004 20.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC79072.1 - 0.00046 19.8 0.1 0.0015 18.1 0.1 1.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EMC79072.1 - 0.00051 19.5 0.0 0.00076 18.9 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 EMC79072.1 - 0.0082 15.7 0.0 3.5 7.1 0.0 2.1 2 0 0 2 2 2 2 Ferrous iron transport protein B G-alpha PF00503.20 EMC79072.1 - 0.017 14.3 0.4 5.6 6.0 0.0 2.9 1 1 1 2 2 2 0 G-protein alpha subunit RsgA_GTPase PF03193.16 EMC79072.1 - 0.018 15.0 0.0 1.8 8.4 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase DUF2757 PF10955.8 EMC79072.1 - 0.022 15.0 0.1 0.039 14.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) AAA_24 PF13479.6 EMC79072.1 - 0.046 13.4 0.4 0.11 12.2 0.4 1.8 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EMC79072.1 - 0.12 12.8 0.0 0.23 11.8 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain Thioredoxin_7 PF13899.6 EMC79073.1 - 3.5e-18 65.6 0.0 5.5e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 EMC79073.1 - 1.7e-06 28.0 0.0 2.5e-06 27.4 0.0 1.3 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EMC79073.1 - 0.00024 21.5 0.0 0.00039 20.8 0.0 1.6 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredox_DsbH PF03190.15 EMC79073.1 - 0.0048 16.9 0.1 0.0056 16.7 0.1 1.4 1 1 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_9 PF14595.6 EMC79073.1 - 0.008 16.0 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EMC79073.1 - 0.0086 16.4 0.2 0.045 14.1 0.0 2.1 2 1 0 2 2 2 1 Thioredoxin-like AhpC-TSA PF00578.21 EMC79073.1 - 0.016 15.1 0.0 0.02 14.8 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA family Glutaredoxin PF00462.24 EMC79073.1 - 0.057 13.6 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin NAC PF01849.18 EMC79074.1 - 4.7e-25 87.3 0.1 8.1e-25 86.6 0.1 1.4 1 0 0 1 1 1 1 NAC domain DUF3480 PF11979.8 EMC79075.1 - 2.6e-164 546.3 0.0 3.8e-164 545.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3480) SARA PF11409.8 EMC79075.1 - 5.9e-19 68.0 10.6 5.9e-19 68.0 10.6 2.8 3 0 0 3 3 3 1 Smad anchor for receptor activation (SARA) FYVE PF01363.21 EMC79075.1 - 4.6e-18 65.1 15.9 4.6e-18 65.1 15.9 2.4 2 0 0 2 2 2 1 FYVE zinc finger Band_3_cyto PF07565.13 EMC79075.1 - 0.14 11.9 0.1 0.38 10.5 0.1 1.7 1 0 0 1 1 1 0 Band 3 cytoplasmic domain C2 PF00168.30 EMC79076.1 - 3.2e-09 37.0 0.0 8e-09 35.7 0.0 1.7 1 0 0 1 1 1 1 C2 domain Velvet PF11754.8 EMC79076.1 - 0.018 15.0 0.2 0.055 13.4 0.2 1.7 1 0 0 1 1 1 0 Velvet factor LZ_Tnp_IS66 PF13007.7 EMC79076.1 - 0.36 11.7 0.0 0.36 11.7 0.0 3.3 3 0 0 3 3 3 0 Transposase C of IS166 homeodomain PRP38 PF03371.15 EMC79077.1 - 1.1e-63 214.2 0.9 1.4e-63 213.9 0.9 1.1 1 0 0 1 1 1 1 PRP38 family PRP38_assoc PF12871.7 EMC79077.1 - 5.1e-07 30.2 36.9 5.1e-07 30.2 36.9 2.2 1 1 1 2 2 2 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF2457 PF10446.9 EMC79077.1 - 6.7 5.7 39.5 14 4.6 39.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2457) PAP_assoc PF03828.19 EMC79078.1 - 1.8e-30 104.9 0.7 9.7e-16 57.7 0.2 2.9 2 0 0 2 2 2 2 Cid1 family poly A polymerase zf-CCHC PF00098.23 EMC79078.1 - 1.1e-11 44.2 21.7 4.6e-05 23.3 1.0 3.9 3 0 0 3 3 3 3 Zinc knuckle NTP_transf_2 PF01909.23 EMC79078.1 - 1.7e-10 41.0 0.1 1.1e-07 32.1 0.0 2.7 2 0 0 2 2 2 2 Nucleotidyltransferase domain Polbeta PF18765.1 EMC79078.1 - 9e-06 25.7 0.0 0.055 13.6 0.0 2.6 2 0 0 2 2 2 2 Polymerase beta, Nucleotidyltransferase zf-CCHC_4 PF14392.6 EMC79078.1 - 2.5e-05 23.9 14.9 0.25 11.1 0.6 3.7 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 EMC79078.1 - 0.0032 17.3 38.8 0.055 13.3 6.7 5.4 5 0 0 5 5 5 3 Zinc knuckle Ubiq_cyt_C_chap PF03981.12 EMC79078.1 - 0.098 12.7 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Ubiquinol-cytochrome C chaperone Pex14_N PF04695.13 EMC79078.1 - 8.5 7.0 13.0 54 4.4 13.0 2.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region zf-CCHC_6 PF15288.6 EMC79078.1 - 8.8 6.3 10.9 34 4.4 0.2 3.1 2 0 0 2 2 2 0 Zinc knuckle Shisa PF13908.6 EMC79079.1 - 3.2e-06 27.5 6.6 3.2e-06 27.5 6.6 2.0 1 1 1 2 2 2 1 Wnt and FGF inhibitory regulator PDR_assoc PF08370.11 EMC79079.1 - 0.0024 17.6 0.6 0.0045 16.7 0.6 1.4 1 0 0 1 1 1 1 Plant PDR ABC transporter associated PRIMA1 PF16101.5 EMC79079.1 - 0.018 15.1 0.0 0.025 14.6 0.0 1.2 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Sel1 PF08238.12 EMC79080.1 - 7.6e-17 61.4 0.0 2.1e-05 25.0 0.0 4.3 4 0 0 4 4 4 4 Sel1 repeat LRR_4 PF12799.7 EMC79081.1 - 3e-05 24.3 9.0 0.015 15.7 0.3 4.1 2 1 0 3 3 3 2 Leucine Rich repeats (2 copies) DNA_alkylation PF08713.11 EMC79081.1 - 0.032 14.0 1.6 3.8 7.2 0.1 2.7 3 0 0 3 3 3 0 DNA alkylation repair enzyme DUF3361 PF11841.8 EMC79081.1 - 0.1 12.6 13.2 0.15 12.0 0.7 4.6 3 1 2 5 5 5 0 Domain of unknown function (DUF3361) LRR_8 PF13855.6 EMC79081.1 - 0.15 11.9 4.3 2.6 7.9 0.1 3.7 4 0 0 4 4 4 0 Leucine rich repeat His_kinase PF06580.13 EMC79081.1 - 0.15 12.4 1.3 0.36 11.2 0.3 2.1 2 0 0 2 2 2 0 Histidine kinase ECH_1 PF00378.20 EMC79082.1 - 1.1e-52 178.9 0.1 1.2e-52 178.8 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EMC79082.1 - 8e-26 91.3 0.4 3.2e-25 89.3 0.4 1.7 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase LRR_8 PF13855.6 EMC79083.1 - 1.9e-71 235.7 59.2 1.2e-15 57.0 3.2 9.4 7 4 1 9 9 9 9 Leucine rich repeat LRR_4 PF12799.7 EMC79083.1 - 1.4e-44 149.3 64.1 5.8e-07 29.7 0.4 11.8 6 3 8 14 14 14 14 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC79083.1 - 1.3e-23 83.4 4.2 7.6e-07 29.1 0.0 5.2 2 1 4 6 6 6 6 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EMC79083.1 - 1.1e-18 64.8 46.0 0.76 10.6 0.3 15.5 14 2 0 14 14 14 5 Leucine Rich Repeat LRR_9 PF14580.6 EMC79083.1 - 6.7e-15 55.0 25.3 0.0025 17.3 1.2 6.8 1 1 5 7 7 7 5 Leucine-rich repeat LRR_6 PF13516.6 EMC79083.1 - 1.9e-10 40.0 46.6 0.7 10.1 0.5 13.4 15 0 0 15 15 15 5 Leucine Rich repeat FNIP PF05725.12 EMC79083.1 - 0.022 14.9 21.7 6.8 6.9 0.3 7.7 5 2 2 7 7 7 0 FNIP Repeat LRRNT PF01462.18 EMC79083.1 - 1.1 9.0 5.0 27 4.6 0.1 4.0 5 0 0 5 5 5 0 Leucine rich repeat N-terminal domain SDF PF00375.18 EMC79084.1 - 2.4e-125 418.6 27.9 2.8e-125 418.4 27.9 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family DUF2417 PF10329.9 EMC79084.1 - 0.086 12.2 0.9 0.12 11.7 0.1 1.7 2 0 0 2 2 2 0 Region of unknown function (DUF2417) Carn_acyltransf PF00755.20 EMC79085.1 - 2e-196 654.1 0.0 2.3e-196 654.0 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase DUF866 PF05907.13 EMC79086.1 - 1.8e-41 141.6 0.1 2e-41 141.5 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) Mago_nashi PF02792.14 EMC79087.1 - 2.9e-60 202.5 0.1 3.2e-60 202.4 0.1 1.0 1 0 0 1 1 1 1 Mago nashi protein Ldl_recept_a PF00057.18 EMC79088.1 - 1.2e-80 265.4 146.1 4.7e-14 52.3 10.6 8.0 8 0 0 8 8 7 7 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 EMC79088.1 - 2.2e-59 197.7 8.3 4.5e-15 55.8 0.0 5.4 5 0 0 5 5 5 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 EMC79088.1 - 1.3e-16 60.6 36.9 4.6e-09 36.4 8.0 6.2 6 1 0 6 6 3 3 Coagulation Factor Xa inhibitory site SGL PF08450.12 EMC79088.1 - 2.9e-07 30.3 0.7 0.0063 16.1 0.0 2.6 1 1 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region cEGF PF12662.7 EMC79088.1 - 1.3e-06 28.2 1.6 1.3e-06 28.2 1.6 6.1 5 0 0 5 5 4 2 Complement Clr-like EGF-like EGF_CA PF07645.15 EMC79088.1 - 3.6e-06 27.1 11.3 3.6e-06 27.1 11.3 10.2 6 2 3 9 9 7 2 Calcium-binding EGF domain EGF PF00008.27 EMC79088.1 - 0.00023 21.4 19.7 0.00058 20.1 4.7 9.2 9 0 0 9 9 8 2 EGF-like domain SKG6 PF08693.10 EMC79088.1 - 0.0017 17.8 0.9 0.0037 16.6 0.9 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TMEM154 PF15102.6 EMC79088.1 - 0.0061 16.5 0.4 0.013 15.4 0.4 1.5 1 0 0 1 1 1 1 TMEM154 protein family Arylesterase PF01731.20 EMC79088.1 - 0.028 14.6 0.0 4.2 7.6 0.0 3.3 3 0 0 3 3 3 0 Arylesterase Polyhedrin PF00738.18 EMC79088.1 - 0.046 13.0 0.1 0.076 12.3 0.1 1.2 1 0 0 1 1 1 0 Polyhedrin NHL PF01436.21 EMC79088.1 - 0.19 11.8 5.1 4 7.6 0.0 5.2 9 0 0 9 9 8 0 NHL repeat PSI_8 PF00796.18 EMC79088.1 - 1.3 8.9 4.4 2.3 8.1 4.4 1.4 1 0 0 1 1 1 0 Photosystem I reaction centre subunit VIII DM PF00751.18 EMC79089.1 - 1.2e-19 70.0 7.8 1.7e-19 69.4 7.8 1.3 1 0 0 1 1 1 1 DM DNA binding domain zf-C2H2 PF00096.26 EMC79090.1 - 3.7e-16 58.6 29.1 0.00097 19.5 0.6 6.9 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC79090.1 - 4.7e-11 42.6 20.2 4.8e-05 23.6 0.8 5.6 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC79090.1 - 1.9e-07 31.4 26.0 0.005 17.6 0.2 6.7 6 0 0 6 6 6 4 C2H2-type zinc finger FOXP-CC PF16159.5 EMC79090.1 - 7e-07 29.8 18.1 0.004 17.7 0.2 5.6 1 1 4 5 5 5 3 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 EMC79090.1 - 0.0054 17.0 15.0 0.11 12.8 1.9 4.8 2 1 4 6 6 6 5 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 EMC79090.1 - 0.027 14.5 3.0 1.6 8.8 0.1 4.0 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC79090.1 - 0.081 13.2 6.6 14 6.1 0.2 4.0 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_aberr PF17017.5 EMC79090.1 - 0.086 13.0 9.9 14 5.8 0.2 4.5 1 1 3 4 4 4 0 Aberrant zinc-finger DHR10 PF18595.1 EMC79090.1 - 0.23 11.5 2.7 1 9.4 0.7 2.4 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain zf-met PF12874.7 EMC79090.1 - 0.45 11.0 7.0 3.2 8.3 0.1 3.6 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Yip1 PF04893.17 EMC79091.1 - 5.6e-20 71.8 11.5 7.7e-20 71.3 11.5 1.2 1 0 0 1 1 1 1 Yip1 domain T4_deiodinase PF00837.17 EMC79092.1 - 1.2e-22 80.3 0.0 1.5e-22 80.1 0.0 1.0 1 0 0 1 1 1 1 Iodothyronine deiodinase PRIMA1 PF16101.5 EMC79092.1 - 6.9e-06 26.1 0.2 9.5e-06 25.6 0.2 1.2 1 0 0 1 1 1 1 Proline-rich membrane anchor 1 Ldl_recept_a PF00057.18 EMC79094.1 - 2.2e-12 46.9 28.6 1.6e-06 28.2 4.5 3.4 3 1 0 3 3 3 3 Low-density lipoprotein receptor domain class A BSMAP PF12280.8 EMC79095.1 - 2.7e-70 236.5 0.5 2.7e-70 236.5 0.5 2.1 2 0 0 2 2 2 2 Brain specific membrane anchored protein Med26 PF08711.11 EMC79096.1 - 3.8e-11 42.8 0.4 3.8e-11 42.8 0.4 2.7 3 1 1 4 4 4 1 TFIIS helical bundle-like domain TFIIS_M PF07500.14 EMC79096.1 - 3.7e-08 33.8 0.3 1.9e-07 31.5 0.1 2.0 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TssR PF17643.1 EMC79096.1 - 0.055 11.4 0.0 0.065 11.2 0.0 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssR CUB PF00431.20 EMC79098.1 - 4.7e-94 310.2 0.0 3.4e-32 111.0 0.0 3.0 3 0 0 3 3 3 3 CUB domain CUB_2 PF02408.20 EMC79098.1 - 0.00017 21.3 0.1 0.09 12.5 0.0 3.3 4 0 0 4 4 4 1 CUB-like domain NAD_binding_1 PF00175.21 EMC79099.1 - 2.1e-13 50.9 0.0 1.3e-12 48.3 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EMC79099.1 - 2.2e-13 50.4 0.0 3.7e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Oxidored-like PF09791.9 EMC79099.1 - 3.1e-12 45.9 2.2 6.4e-11 41.7 3.4 2.2 2 0 0 2 2 2 1 Oxidoreductase-like protein, N-terminal NAD_binding_6 PF08030.12 EMC79099.1 - 0.00018 21.6 0.2 0.017 15.3 0.0 2.8 2 1 0 3 3 3 1 Ferric reductase NAD binding domain TrbC_Ftype PF09673.10 EMC79099.1 - 0.0026 17.8 0.0 0.35 10.9 0.0 2.3 2 0 0 2 2 2 1 Type-F conjugative transfer system pilin assembly protein DUF5522 PF17653.1 EMC79099.1 - 0.6 10.1 7.7 0.16 11.9 4.1 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5522) PDCD9 PF07147.12 EMC79100.1 - 2.3e-11 43.6 0.1 6.6e-09 35.5 0.1 2.2 2 0 0 2 2 2 2 Mitochondrial 28S ribosomal protein S30 (PDCD9) Thi4 PF01946.17 EMC79100.1 - 0.13 11.5 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 Thi4 family SSDP PF04503.13 EMC79101.1 - 5.8e-90 302.5 74.3 6.6e-90 302.3 74.3 1.0 1 0 0 1 1 1 1 Single-stranded DNA binding protein, SSDP START PF01852.19 EMC79102.1 - 3.8e-29 101.6 0.1 6.1e-29 100.9 0.1 1.3 1 0 0 1 1 1 1 START domain 4HBT PF03061.22 EMC79102.1 - 2.9e-21 75.6 0.1 7.6e-10 39.0 0.0 2.4 2 0 0 2 2 2 2 Thioesterase superfamily TPR_1 PF00515.28 EMC79103.1 - 1.3e-15 56.4 2.4 0.00042 20.0 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EMC79103.1 - 5.4e-13 48.0 1.6 0.0067 16.5 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EMC79103.1 - 6.9e-07 29.0 0.5 0.14 12.5 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 EMC79103.1 - 0.00033 21.3 0.0 0.037 14.7 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC79103.1 - 0.00094 19.4 0.3 0.0023 18.1 0.3 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EMC79103.1 - 0.0032 17.9 0.0 0.0071 16.8 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 EMC79103.1 - 0.0039 17.9 0.0 0.68 10.9 0.0 3.3 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMC79103.1 - 0.0057 16.3 0.2 1.6 8.5 0.7 3.2 2 1 0 2 2 2 1 TPR repeat TPR_12 PF13424.6 EMC79103.1 - 0.039 14.2 1.0 1.7 9.0 0.2 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat tRNA-synt_2b PF00587.25 EMC79104.1 - 2.3e-36 125.4 0.0 3.2e-36 125.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EMC79104.1 - 1.1e-05 25.4 0.0 1.9e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_His PF13393.6 EMC79104.1 - 0.016 14.5 0.0 0.023 14.0 0.0 1.2 1 0 0 1 1 1 0 Histidyl-tRNA synthetase FAD_binding_4 PF01565.23 EMC79105.1 - 7.7e-17 61.3 0.1 1.2e-16 60.7 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain TMEM61 PF15105.6 EMC79106.1 - 3.4e-46 157.5 1.1 4e-46 157.2 1.1 1.0 1 0 0 1 1 1 1 TMEM61 protein family CD20 PF04103.15 EMC79106.1 - 0.042 13.9 0.4 0.2 11.7 0.0 1.9 2 0 0 2 2 2 0 CD20-like family Barttin PF15462.6 EMC79107.1 - 2.8e-38 131.9 4.2 1.6e-37 129.4 3.9 2.1 1 1 0 1 1 1 1 Bartter syndrome, infantile, with sensorineural deafness (Barttin) Peptidase_S8 PF00082.22 EMC79108.1 - 4.1e-24 85.4 4.6 1.4e-23 83.6 4.6 1.7 1 1 0 1 1 1 1 Subtilase family UCH PF00443.29 EMC79109.1 - 3e-46 158.0 1.6 4e-46 157.6 0.1 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMC79109.1 - 2.4e-31 109.5 0.0 7.2e-31 108.0 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DZR PF12773.7 EMC79109.1 - 6.1 7.0 7.5 5.1 7.2 1.3 3.1 3 0 0 3 3 3 0 Double zinc ribbon PAP2 PF01569.21 EMC79110.1 - 3.8e-26 91.5 3.4 5.3e-26 91.0 2.1 1.8 2 0 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 EMC79110.1 - 7.3e-05 23.2 3.1 7.3e-05 23.2 3.1 1.8 2 0 0 2 2 2 1 PAP2 superfamily C-terminal PAP2_3 PF14378.6 EMC79110.1 - 0.0076 16.0 1.3 0.023 14.4 1.3 1.6 1 1 0 1 1 1 1 PAP2 superfamily FSH1 PF03959.13 EMC79110.1 - 0.17 11.6 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) YhhN PF07947.14 EMC79110.1 - 1.8 8.1 8.4 1.4 8.5 6.2 1.8 2 1 0 2 2 2 0 YhhN family hSH3 PF14603.6 EMC79111.1 - 8.5e-15 55.0 0.1 2e-14 53.8 0.0 1.6 2 0 0 2 2 2 1 Helically-extended SH3 domain SH3_16 PF18348.1 EMC79111.1 - 0.19 11.5 0.1 1.1 9.1 0.0 1.9 2 0 0 2 2 2 0 Bacterial dipeptidyl-peptidase Sh3 domain MACPF PF01823.19 EMC79112.1 - 2.5e-42 145.3 0.1 1.7e-41 142.7 0.0 1.9 2 0 0 2 2 2 1 MAC/Perforin domain Ldl_recept_a PF00057.18 EMC79112.1 - 7.1e-11 42.1 11.9 7.1e-11 42.1 11.9 2.9 1 1 1 2 2 2 1 Low-density lipoprotein receptor domain class A TSP_1 PF00090.19 EMC79112.1 - 4.7e-05 23.5 27.5 0.0005 20.2 12.3 3.8 4 0 0 4 4 4 2 Thrombospondin type 1 domain MACPF PF01823.19 EMC79113.1 - 4.8e-37 128.1 0.1 7.9e-37 127.4 0.1 1.3 1 0 0 1 1 1 1 MAC/Perforin domain Ldl_recept_a PF00057.18 EMC79113.1 - 1.4e-08 34.8 12.2 3.3e-08 33.6 11.0 2.4 1 1 0 1 1 1 1 Low-density lipoprotein receptor domain class A TSP_1 PF00090.19 EMC79113.1 - 1.8e-07 31.3 34.5 4.1e-05 23.7 10.6 3.7 3 0 0 3 3 3 2 Thrombospondin type 1 domain PID PF00640.23 EMC79114.1 - 3.2e-08 33.7 0.1 5.3e-08 33.0 0.1 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Peptidase_M48 PF01435.18 EMC79115.1 - 2.5e-31 109.0 0.1 3.5e-31 108.5 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M48 Sulf_transp PF04143.14 EMC79115.1 - 0.14 11.7 0.5 0.24 10.9 0.1 1.5 2 0 0 2 2 2 0 Sulphur transport SWIRM PF04433.17 EMC79116.1 - 6.9e-21 74.4 0.0 2.4e-20 72.7 0.0 2.0 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-binding PF00249.31 EMC79116.1 - 1.1e-12 47.9 0.2 3.1e-12 46.5 0.2 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain JAB PF01398.21 EMC79116.1 - 6.5e-12 45.5 0.0 1.5e-11 44.3 0.0 1.7 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 EMC79116.1 - 3.8e-09 36.3 0.0 1e-08 35.0 0.0 1.7 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Myb_DNA-bind_6 PF13921.6 EMC79116.1 - 0.00022 21.4 0.6 0.00079 19.6 0.6 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain UPF0172 PF03665.13 EMC79116.1 - 0.004 17.2 0.0 0.0095 16.0 0.0 1.6 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) Myb_DNA-bind_7 PF15963.5 EMC79116.1 - 0.011 15.6 0.5 0.05 13.5 0.5 2.1 1 0 0 1 1 1 0 Myb DNA-binding like TetR_C_19 PF17924.1 EMC79116.1 - 0.67 10.6 3.0 21 5.7 0.2 2.9 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Ank_2 PF12796.7 EMC79117.1 - 1.5e-82 272.3 29.1 1.1e-20 74.0 0.1 6.7 2 2 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC79117.1 - 3.7e-74 244.2 23.2 1.4e-10 41.5 0.0 11.0 2 2 12 14 14 14 13 Ankyrin repeats (many copies) Ank PF00023.30 EMC79117.1 - 1.4e-69 227.7 41.3 4.3e-06 26.9 0.1 14.3 14 1 1 15 15 15 13 Ankyrin repeat Ank_3 PF13606.6 EMC79117.1 - 3.4e-69 220.6 16.5 0.00023 21.3 0.0 14.4 15 0 0 15 15 15 14 Ankyrin repeat Ank_5 PF13857.6 EMC79117.1 - 6.9e-64 211.1 21.2 4.6e-10 39.5 0.1 11.9 2 2 10 12 12 12 12 Ankyrin repeats (many copies) FGGY_C PF02782.16 EMC79118.1 - 6.4e-48 163.1 0.1 9.9e-48 162.5 0.1 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EMC79118.1 - 2.7e-27 95.9 0.0 3.9e-27 95.4 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 EMC79118.1 - 0.021 14.3 0.1 0.24 10.9 0.1 2.5 3 0 0 3 3 3 0 BadF/BadG/BcrA/BcrD ATPase family HSP70 PF00012.20 EMC79118.1 - 0.14 10.3 0.0 0.19 9.8 0.0 1.1 1 0 0 1 1 1 0 Hsp70 protein zf-C3HC4 PF00097.25 EMC79119.1 - 9e-10 38.3 7.7 1.8e-09 37.3 7.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC79119.1 - 1.7e-09 37.5 4.9 1.7e-09 37.5 4.9 1.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EMC79119.1 - 5.7e-09 35.7 4.6 1.1e-08 34.8 4.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMC79119.1 - 6.3e-09 35.9 6.2 6.3e-09 35.9 6.2 1.8 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EMC79119.1 - 8.8e-08 32.4 9.0 1.8e-07 31.3 9.0 1.6 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EMC79119.1 - 1e-07 31.7 11.7 1.5e-06 27.9 1.2 2.4 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EMC79119.1 - 1e-06 28.5 9.1 2.6e-06 27.1 9.1 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC79119.1 - 1.3e-05 25.1 9.9 5.7e-05 23.0 8.5 2.4 1 1 1 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EMC79119.1 - 0.0096 15.9 6.7 0.074 13.1 5.8 2.1 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EMC79119.1 - 0.034 14.4 11.4 0.034 14.4 11.4 1.6 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-Nse PF11789.8 EMC79119.1 - 0.1 12.4 6.4 0.17 11.7 5.9 1.6 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DUF4020 PF13212.6 EMC79119.1 - 0.16 11.8 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4020) Baculo_IE-1 PF05290.11 EMC79119.1 - 0.4 10.6 9.8 0.73 9.8 9.7 1.6 1 1 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_4 PF14570.6 EMC79119.1 - 0.64 9.9 9.4 9.7 6.1 8.8 2.4 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain TerY_C PF15616.6 EMC79119.1 - 2.9 8.0 8.0 10 6.2 7.9 1.8 1 1 0 1 1 1 0 TerY-C metal binding domain HOOK PF05622.12 EMC79120.1 - 0 1020.7 80.3 0 1020.6 80.3 1.0 1 0 0 1 1 1 1 HOOK protein ATG16 PF08614.11 EMC79120.1 - 6.6e-06 26.5 89.9 0.12 12.6 12.0 5.4 1 1 3 4 4 4 3 Autophagy protein 16 (ATG16) Spc7 PF08317.11 EMC79120.1 - 2.4e-05 23.4 15.2 2.4e-05 23.4 15.2 5.2 1 1 4 5 5 5 1 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 EMC79120.1 - 0.00084 19.4 21.4 0.00084 19.4 21.4 5.9 2 2 2 5 5 5 1 TPR/MLP1/MLP2-like protein DUF4200 PF13863.6 EMC79120.1 - 0.013 15.8 11.6 0.013 15.8 11.6 6.0 2 1 4 6 6 6 0 Domain of unknown function (DUF4200) GAS PF13851.6 EMC79120.1 - 0.53 9.6 103.4 0.038 13.3 20.9 5.7 1 1 4 6 6 6 0 Growth-arrest specific micro-tubule binding Laminin_II PF06009.12 EMC79120.1 - 6.4 6.8 54.6 0.6 10.1 3.3 5.7 2 2 4 6 6 6 0 Laminin Domain II Vip3A_N PF12495.8 EMC79120.1 - 9.4 6.1 15.1 1.1 9.1 3.0 3.4 2 1 1 3 3 3 0 Vegetative insecticide protein 3A N terminal p450 PF00067.22 EMC79121.1 - 3.3e-135 451.4 0.1 3.8e-135 451.2 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EMC79122.1 - 1.2e-132 442.9 0.4 1.4e-132 442.7 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EMC79123.1 - 1.3e-130 436.3 0.1 1.5e-130 436.1 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EMC79124.1 - 7.9e-14 51.3 0.0 8.9e-14 51.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EMC79126.1 - 5.1e-42 144.2 0.1 5.7e-42 144.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EMC79127.1 - 2.5e-10 39.7 0.6 2.6e-10 39.7 0.6 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cadherin_3 PF16184.5 EMC79128.1 - 0.00019 21.4 0.1 0.12 12.4 0.0 2.2 2 0 0 2 2 2 2 Cadherin-like Clathrin PF00637.20 EMC79128.1 - 0.0089 15.9 0.0 0.013 15.4 0.0 1.2 1 0 0 1 1 1 1 Region in Clathrin and VPS TM2 PF05154.16 EMC79132.1 - 4.5e-17 62.1 5.5 6.6e-17 61.6 5.5 1.2 1 0 0 1 1 1 1 TM2 domain Nitrate_red_gam PF02665.14 EMC79132.1 - 0.029 13.9 0.1 0.032 13.8 0.1 1.1 1 0 0 1 1 1 0 Nitrate reductase gamma subunit PDZ PF00595.24 EMC79133.1 - 3.5e-17 62.5 0.0 2.2e-10 40.7 0.0 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 EMC79133.1 - 1.3e-13 50.5 0.0 2.1e-07 30.7 0.1 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 EMC79133.1 - 3.3e-06 27.3 0.0 0.023 15.0 0.0 2.5 2 0 0 2 2 2 2 PDZ domain Mucin15 PF15672.5 EMC79133.1 - 0.05 13.1 0.1 0.078 12.5 0.1 1.2 1 0 0 1 1 1 0 Cell-membrane associated Mucin15 Ank_5 PF13857.6 EMC79134.1 - 2.7e-24 84.9 3.8 4.5e-14 52.3 0.1 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC79134.1 - 2.2e-23 82.7 2.0 3e-11 43.7 0.1 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EMC79134.1 - 3.4e-19 68.3 2.3 7.8e-05 22.9 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EMC79134.1 - 5.9e-18 65.0 0.6 4.3e-08 33.6 0.0 4.3 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC79134.1 - 1.6e-16 58.7 0.5 0.00085 19.6 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat DUF1870 PF08965.10 EMC79134.1 - 0.06 13.4 0.0 0.21 11.6 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1870) UCH PF00443.29 EMC79136.1 - 3.9e-37 128.1 0.1 1.8e-31 109.6 0.0 2.7 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMC79136.1 - 1.7e-11 44.3 13.6 1.5e-08 34.6 14.7 3.4 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase CDC45 PF02724.14 EMC79136.1 - 1.5 7.1 8.8 2.4 6.3 8.8 1.3 1 0 0 1 1 1 0 CDC45-like protein Peroxin-3 PF04882.12 EMC79136.1 - 4.8 6.1 12.8 14 4.5 12.8 1.7 1 0 0 1 1 1 0 Peroxin-3 Fibrinogen_C PF00147.18 EMC79137.1 - 5.1e-52 176.9 1.0 9.3e-52 176.0 1.0 1.4 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain UPF0242 PF06785.11 EMC79137.1 - 0.0015 18.7 17.2 0.0024 18.0 17.2 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus DUF1664 PF07889.12 EMC79137.1 - 0.02 14.9 1.9 0.02 14.9 1.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) YscJ_FliF_C PF08345.11 EMC79137.1 - 0.05 13.9 0.3 0.11 12.9 0.3 1.5 1 0 0 1 1 1 0 Flagellar M-ring protein C-terminal USP8_interact PF08941.10 EMC79137.1 - 0.26 11.1 9.0 2.5 7.9 2.6 2.2 2 0 0 2 2 2 0 USP8 interacting DUF1465 PF07323.12 EMC79137.1 - 1.7 8.5 6.6 0.98 9.3 4.4 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1465) DUF4559 PF15112.6 EMC79137.1 - 3.9 7.1 18.3 5.8 6.5 18.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) Peptidase_C54 PF03416.19 EMC79138.1 - 2.4e-106 355.2 0.0 3.7e-106 354.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family C54 Alg6_Alg8 PF03155.15 EMC79139.1 - 2e-132 442.6 27.0 2.5e-132 442.3 27.0 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family CENP-R PF06729.12 EMC79140.1 - 2.3e-59 199.2 4.7 2.7e-59 199.0 4.7 1.0 1 0 0 1 1 1 1 Kinetochore component, CENP-R EF-hand_7 PF13499.6 EMC79141.1 - 1.2e-15 57.7 1.2 2.1e-10 40.9 0.1 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 EMC79141.1 - 2.9e-14 51.5 1.9 0.0044 16.5 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EMC79141.1 - 3.8e-10 39.5 6.6 1.2e-06 28.2 0.0 3.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EMC79141.1 - 4.3e-09 35.6 2.8 0.00055 19.7 0.1 4.1 3 1 1 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 EMC79141.1 - 6e-05 22.4 1.3 0.032 13.7 0.3 2.8 3 0 0 3 3 3 2 EF hand EFhand_Ca_insen PF08726.10 EMC79141.1 - 0.027 14.6 0.0 0.062 13.4 0.0 1.6 1 0 0 1 1 1 0 Ca2+ insensitive EF hand EF-hand_4 PF12763.7 EMC79141.1 - 0.035 14.1 0.4 1.8 8.5 0.0 3.2 3 0 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand DUF3085 PF11284.8 EMC79141.1 - 0.054 13.8 0.0 2.2 8.7 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3085) EF_assoc_2 PF08356.12 EMC79141.1 - 0.066 13.2 0.0 0.23 11.5 0.0 1.9 1 0 0 1 1 1 0 EF hand associated UPF0154 PF03672.13 EMC79141.1 - 0.067 13.2 0.0 0.18 11.8 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) PGM_PMM_I PF02878.16 EMC79142.1 - 2e-34 118.3 0.1 3.4e-34 117.5 0.1 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EMC79142.1 - 2e-31 108.5 0.0 3.5e-31 107.7 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EMC79142.1 - 8.2e-19 68.1 0.0 1.6e-18 67.2 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EMC79142.1 - 1.3e-05 25.3 0.0 2.8e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain VWA_N PF08399.11 EMC79143.1 - 6.2e-22 78.4 0.1 5e-19 69.0 0.1 3.3 2 1 0 2 2 2 1 VWA N-terminal dCache_1 PF02743.18 EMC79143.1 - 2.9e-15 56.8 2.2 3.2e-09 37.0 0.0 3.1 3 0 0 3 3 3 2 Cache domain VWA PF00092.28 EMC79143.1 - 1.2e-07 32.2 1.2 2.2e-07 31.3 1.2 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EMC79143.1 - 6.4e-06 26.8 0.4 1.8e-05 25.3 0.4 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EMC79143.1 - 0.059 13.3 0.2 0.13 12.2 0.2 1.6 1 0 0 1 1 1 0 von Willebrand factor type A domain RRM_1 PF00076.22 EMC79144.1 - 2.8e-27 94.3 3.3 4.7e-14 52.0 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMC79144.1 - 0.00013 21.7 0.0 1.9 8.4 0.0 3.5 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_5 PF13893.6 EMC79144.1 - 0.037 13.6 0.7 14 5.3 0.0 3.7 3 1 1 4 4 4 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DbpA PF03880.15 EMC79144.1 - 0.13 12.2 0.1 7.9 6.6 0.0 2.4 2 0 0 2 2 2 0 DbpA RNA binding domain ADK PF00406.22 EMC79145.1 - 6.1e-29 101.1 0.0 7.1e-29 100.9 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.14 EMC79145.1 - 1.3e-16 60.3 0.0 2.7e-16 59.2 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.6 EMC79145.1 - 0.00026 21.4 0.0 0.00047 20.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMC79145.1 - 0.0078 16.8 0.0 0.013 16.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain PTEN_C2 PF10409.9 EMC79146.1 - 3.1e-28 98.2 0.0 6.8e-28 97.1 0.0 1.5 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DnaJ PF00226.31 EMC79146.1 - 2e-06 27.8 0.0 4.4e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain Y_phosphatase PF00102.27 EMC79146.1 - 0.0064 16.1 0.1 0.011 15.3 0.1 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Vps55 PF04133.14 EMC79147.1 - 4.1e-39 133.2 6.6 4.6e-39 133.0 6.6 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 ObR_Ig PF18589.1 EMC79148.1 - 1.2e-69 231.3 8.1 8.4e-35 119.3 2.1 2.9 2 0 0 2 2 2 2 Obesity receptor immunoglobulin like domain Lep_receptor_Ig PF06328.11 EMC79148.1 - 3.4e-25 87.8 2.5 1.3e-24 85.9 0.7 2.9 2 0 0 2 2 2 1 Ig-like C2-type domain fn3 PF00041.21 EMC79148.1 - 2.1e-09 37.6 10.7 0.0076 16.6 0.0 5.1 5 0 0 5 5 5 3 Fibronectin type III domain PDEase_I PF00233.19 EMC79150.1 - 1.9e-93 312.6 4.8 1.9e-93 312.6 4.8 1.7 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase PDE4_UCR PF18100.1 EMC79150.1 - 3.7e-19 69.5 2.3 1.1e-18 68.0 0.3 2.8 2 1 0 2 2 2 1 Phosphodiesterase 4 upstream conserved regions (UCR) DFP PF04127.15 EMC79150.1 - 0.5 10.2 2.2 0.4 10.5 0.2 1.8 2 0 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein Tctex-1 PF03645.13 EMC79151.1 - 1.7e-25 89.3 0.0 1.9e-25 89.1 0.0 1.0 1 0 0 1 1 1 1 Tctex-1 family MTCP1 PF08991.10 EMC79151.1 - 0.078 13.2 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type Insulin PF00049.18 EMC79152.1 - 2e-07 31.9 2.7 8.2e-07 29.9 2.7 1.8 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.14 EMC79152.1 - 0.0026 17.7 7.1 0.42 10.7 0.1 2.3 2 0 0 2 2 2 2 Nematode insulin-related peptide beta type WD40 PF00400.32 EMC79153.1 - 6.1e-07 30.0 12.4 0.00086 20.1 0.3 6.2 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC79153.1 - 2.4e-05 24.5 0.1 1.1 9.6 0.0 4.6 3 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 EMC79153.1 - 0.0021 16.5 0.0 0.0033 15.8 0.0 1.2 1 0 0 1 1 1 1 WD repeat-containing and planar cell polarity effector protein Fritz ELM2 PF01448.24 EMC79154.1 - 3.1e-11 43.8 2.7 3.2e-10 40.6 0.0 3.1 2 0 0 2 2 2 1 ELM2 domain Myb_DNA-binding PF00249.31 EMC79154.1 - 4.2e-07 30.1 0.1 9.3e-07 28.9 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EMC79154.1 - 0.0047 16.8 0.8 0.02 14.8 0.0 2.5 2 0 0 2 2 2 1 Myb DNA-binding like TPT PF03151.16 EMC79155.1 - 4e-14 52.7 6.4 4.5e-14 52.5 6.4 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EMC79155.1 - 3.8e-05 23.9 18.5 0.0044 17.2 8.5 2.2 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 EMC79155.1 - 0.0014 17.6 1.0 0.0014 17.6 1.0 2.1 1 1 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like UAA PF08449.11 EMC79155.1 - 0.0019 17.5 11.9 0.0026 17.0 11.9 1.2 1 0 0 1 1 1 1 UAA transporter family HABP4_PAI-RBP1 PF04774.15 EMC79158.1 - 2e-32 112.5 10.7 2e-32 112.5 10.7 1.8 2 0 0 2 2 2 1 Hyaluronan / mRNA binding family IHABP4_N PF16174.5 EMC79158.1 - 3.1e-07 31.1 10.4 3.1e-07 31.1 10.4 2.4 2 1 0 2 2 2 1 Intracellular hyaluronan-binding protein 4 N-terminal DUF5320 PF17253.2 EMC79158.1 - 0.0021 19.1 5.3 0.017 16.2 3.2 2.4 2 0 0 2 2 2 1 Family of unknown function (DUF5320) Ribosomal_L7Ae PF01248.26 EMC79159.1 - 8.2e-16 57.5 0.0 1.1e-15 57.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Tmp39 PF10271.9 EMC79159.1 - 0.046 12.7 0.0 0.046 12.7 0.0 1.1 1 0 0 1 1 1 0 Putative transmembrane protein G-gamma PF00631.22 EMC79160.1 - 1.5e-17 63.3 0.0 1.7e-17 63.2 0.0 1.0 1 0 0 1 1 1 1 GGL domain Ras PF00071.22 EMC79161.1 - 2.1e-46 157.5 0.1 2.6e-46 157.2 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC79161.1 - 4.3e-17 62.4 0.0 8.4e-17 61.5 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC79161.1 - 5.6e-07 29.2 0.0 8.6e-07 28.6 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EMC79161.1 - 4e-05 23.6 0.6 0.19 11.6 0.1 2.4 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EMC79161.1 - 0.00042 20.4 0.0 0.00077 19.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EMC79161.1 - 0.0022 17.5 1.0 0.0085 15.5 1.0 1.9 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EMC79161.1 - 0.004 16.7 0.1 0.025 14.1 0.1 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EMC79161.1 - 0.0059 16.2 0.1 0.02 14.4 0.1 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 EMC79161.1 - 0.0088 15.8 0.3 0.11 12.2 0.0 2.6 3 0 0 3 3 3 1 AAA domain MeaB PF03308.16 EMC79161.1 - 0.014 14.4 0.2 1.5 7.7 0.1 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 EMC79161.1 - 0.019 15.3 0.1 0.024 15.0 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EMC79161.1 - 0.022 15.1 0.2 0.064 13.5 0.2 2.1 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EMC79161.1 - 0.063 13.5 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EMC79161.1 - 0.086 12.8 0.1 0.58 10.1 0.0 2.2 2 1 0 2 2 2 0 NACHT domain MMR_HSR1_Xtn PF16897.5 EMC79161.1 - 0.092 12.8 0.1 0.2 11.7 0.1 1.6 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain MIG-14_Wnt-bd PF06664.12 EMC79162.1 - 1.3e-94 316.8 21.9 1.6e-94 316.4 21.9 1.1 1 0 0 1 1 1 1 Wnt-binding factor required for Wnt secretion DUF5345 PF17280.2 EMC79162.1 - 2.9 7.9 7.9 0.62 10.1 1.2 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5345) RPE65 PF03055.15 EMC79163.1 - 3.3e-119 399.1 0.2 3.7e-119 398.9 0.2 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein DEP PF00610.21 EMC79164.1 - 2.1e-17 62.9 0.0 9.1e-17 60.9 0.0 2.2 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RhoGAP PF00620.27 EMC79164.1 - 3.2e-05 23.8 3.0 0.21 11.4 0.2 3.3 3 0 0 3 3 3 2 RhoGAP domain DUF148 PF02520.17 EMC79164.1 - 0.0063 16.6 1.1 0.02 15.0 1.1 1.8 1 0 0 1 1 1 1 Domain of unknown function DUF148 LRR_8 PF13855.6 EMC79165.1 - 6.3e-64 211.6 109.2 3.3e-12 46.0 8.7 8.0 4 1 7 11 11 11 10 Leucine rich repeat LRR_4 PF12799.7 EMC79165.1 - 5.3e-46 153.8 73.3 3.5e-08 33.6 0.9 11.6 5 4 10 15 15 15 13 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC79165.1 - 2.7e-13 48.4 49.5 0.15 12.7 0.2 15.6 16 1 0 16 16 16 5 Leucine Rich Repeat LRR_9 PF14580.6 EMC79165.1 - 7.8e-09 35.3 31.9 0.0019 17.7 2.8 6.1 2 2 5 7 7 7 5 Leucine-rich repeat LRR_3 PF07725.12 EMC79165.1 - 0.34 10.8 0.1 0.34 10.8 0.1 6.0 7 0 0 7 7 7 0 Leucine Rich Repeat RRM_1 PF00076.22 EMC79166.1 - 0.21 11.4 0.0 0.48 10.3 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GPCR_chapero_1 PF11904.8 EMC79167.1 - 4.7e-61 206.9 0.5 1.1e-60 205.7 0.5 1.5 1 1 0 1 1 1 1 GPCR-chaperone Ank_4 PF13637.6 EMC79167.1 - 0.0045 17.5 0.0 0.0085 16.6 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC79167.1 - 0.018 15.6 0.0 0.041 14.5 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Cys_Met_Meta_PP PF01053.20 EMC79168.1 - 3.4e-146 486.7 0.0 3.9e-146 486.5 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EMC79168.1 - 4.4e-06 26.1 0.1 6.4e-06 25.6 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EMC79168.1 - 9.1e-06 24.9 0.2 1.4e-05 24.3 0.2 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EMC79168.1 - 1.4e-05 24.6 0.0 1.7e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family GDC-P PF02347.16 EMC79168.1 - 0.0016 17.4 0.1 0.0024 16.8 0.1 1.2 1 0 0 1 1 1 1 Glycine cleavage system P-protein 7tm_1 PF00001.21 EMC79169.1 - 2.4e-13 50.0 10.9 3.1e-13 49.7 10.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srbc PF10316.9 EMC79169.1 - 1.2e-07 31.5 6.1 2.1e-07 30.7 6.1 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc Oxidored_q2 PF00420.24 EMC79169.1 - 0.00052 19.6 6.1 0.023 14.3 0.2 2.6 2 1 0 2 2 2 2 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 7TM_GPCR_Srx PF10328.9 EMC79169.1 - 0.0008 19.1 12.8 0.00097 18.8 12.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF4149 PF13664.6 EMC79169.1 - 0.033 14.5 0.7 0.033 14.5 0.7 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4149) zf-RanBP PF00641.18 EMC79170.1 - 8.8e-10 37.7 19.6 1e-06 27.9 9.5 2.4 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others DUF35_N PF12172.8 EMC79170.1 - 0.0069 16.2 6.5 0.57 10.1 0.4 2.3 2 0 0 2 2 2 2 Rubredoxin-like zinc ribbon domain (DUF35_N) BUD22 PF09073.10 EMC79170.1 - 0.43 9.9 35.2 0.6 9.4 35.2 1.2 1 0 0 1 1 1 0 BUD22 Opi1 PF08618.10 EMC79170.1 - 1.4 8.1 20.0 1.8 7.7 20.0 1.1 1 0 0 1 1 1 0 Transcription factor Opi1 Rrn6 PF10214.9 EMC79170.1 - 1.8 6.9 21.9 2.2 6.7 21.9 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DZR PF12773.7 EMC79170.1 - 2.1 8.4 9.2 5.6 7.1 1.9 2.1 1 1 1 2 2 2 0 Double zinc ribbon RecR PF02132.15 EMC79170.1 - 2.4 7.8 7.3 0.57 9.8 1.1 2.3 2 0 0 2 2 2 0 RecR protein Apt1 PF10351.9 EMC79170.1 - 4 6.2 29.0 4.9 5.9 29.0 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Lin-8 PF03353.15 EMC79170.1 - 5.3 6.5 17.3 6.9 6.1 17.3 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist LAP1C PF05609.12 EMC79170.1 - 5.6 5.9 19.7 7 5.6 19.7 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Macoilin PF09726.9 EMC79170.1 - 7.4 5.0 25.2 8.7 4.8 25.2 1.1 1 0 0 1 1 1 0 Macoilin family Transformer PF06495.11 EMC79170.1 - 7.6 6.6 35.7 0.62 10.1 31.2 1.5 2 0 0 2 2 2 0 Fruit fly transformer protein I-set PF07679.16 EMC79171.1 - 5.7e-34 116.1 0.2 7.3e-12 45.2 0.0 3.8 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC79171.1 - 8.5e-34 116.0 0.5 1.6e-13 51.1 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 EMC79171.1 - 1.6e-26 92.4 0.8 2.3e-10 40.7 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 EMC79171.1 - 1.2e-23 83.1 0.5 2.9e-10 40.2 0.0 4.2 4 0 0 4 4 4 4 Immunoglobulin domain V-set PF07686.17 EMC79171.1 - 2.3e-13 50.3 3.5 1.2e-05 25.4 0.0 5.0 3 2 1 4 4 4 3 Immunoglobulin V-set domain Izumo-Ig PF16706.5 EMC79171.1 - 6.6e-07 29.3 0.7 0.002 18.1 0.1 3.4 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 EMC79171.1 - 1.5e-06 28.5 0.0 0.21 12.0 0.0 3.3 3 0 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 EMC79171.1 - 2.8e-05 24.3 0.1 0.57 10.5 0.0 3.3 3 0 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 EMC79171.1 - 0.0009 19.3 0.0 0.7 10.0 0.0 2.7 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 EMC79171.1 - 0.0012 18.4 0.0 0.95 9.1 0.0 3.1 3 0 0 3 3 3 1 Immunoglobulin domain Adeno_E3_CR1 PF02440.15 EMC79171.1 - 0.0044 16.8 2.1 0.92 9.3 0.1 3.6 3 1 0 3 3 3 1 Adenovirus E3 region protein CR1 Ig_C17orf99 PF17736.1 EMC79171.1 - 0.0073 16.3 0.1 0.12 12.4 0.0 2.8 3 1 0 3 3 3 1 C17orf99 Ig domain V-set_CD47 PF08204.11 EMC79171.1 - 0.009 16.0 0.1 7.7 6.5 0.1 2.8 3 0 0 3 3 3 2 CD47 immunoglobulin-like domain LBP_BPI_CETP PF01273.25 EMC79172.1 - 2.7 7.6 4.7 1.9 8.1 2.1 2.0 1 1 1 2 2 2 0 LBP / BPI / CETP family, N-terminal domain Pkinase_Tyr PF07714.17 EMC79173.1 - 1.3e-51 175.3 0.0 1.6e-51 175.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC79173.1 - 9.7e-46 156.3 0.0 2e-45 155.3 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain RIO1 PF01163.22 EMC79173.1 - 0.0031 17.2 0.9 0.026 14.1 0.1 2.1 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.14 EMC79173.1 - 0.0067 15.8 0.0 0.0092 15.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMC79173.1 - 0.013 15.5 0.0 0.019 14.9 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EMC79173.1 - 0.033 13.5 0.0 0.05 12.9 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Pkinase_fungal PF17667.1 EMC79173.1 - 0.061 12.1 0.0 0.13 11.0 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase FTA2 PF13095.6 EMC79173.1 - 0.15 11.6 0.0 0.32 10.6 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Ank_2 PF12796.7 EMC79173.1 - 0.16 12.5 0.0 0.38 11.4 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) DUF4590 PF15257.6 EMC79174.1 - 9.5e-58 193.1 0.8 1.3e-57 192.7 0.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4590) ADH_zinc_N PF00107.26 EMC79175.1 - 5.7e-24 84.6 0.8 1.5e-23 83.2 0.2 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMC79175.1 - 6e-17 62.9 0.0 1.1e-16 62.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMC79175.1 - 3.7e-12 46.1 0.1 2.6e-11 43.4 0.1 2.2 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain TYW3 PF02676.14 EMC79176.1 - 8.8e-31 106.9 0.2 9.3e-31 106.9 0.2 1.0 1 0 0 1 1 1 1 Methyltransferase TYW3 Choline_transpo PF04515.12 EMC79177.1 - 5.9e-113 377.4 34.2 5.9e-113 377.4 34.2 2.6 3 0 0 3 3 3 2 Plasma-membrane choline transporter Acyl-CoA_dh_1 PF00441.24 EMC79178.1 - 2.3e-48 164.2 4.8 3.8e-48 163.5 4.8 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EMC79178.1 - 3.5e-27 94.4 0.0 6.9e-27 93.5 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EMC79178.1 - 1.3e-26 93.4 0.1 2.6e-26 92.5 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EMC79178.1 - 1.4e-20 73.9 2.8 2.2e-20 73.3 2.8 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 EMC79178.1 - 0.00036 20.3 0.0 0.0016 18.2 0.0 2.1 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal Prenyltrans PF00432.21 EMC79179.1 - 3.8e-72 237.7 7.3 2.9e-15 55.7 0.1 5.9 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 EMC79179.1 - 0.00027 20.1 0.0 0.00079 18.6 0.0 1.7 2 1 0 2 2 2 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EMC79179.1 - 0.038 13.1 0.0 3.4 6.7 0.0 3.1 2 2 2 4 4 4 0 Squalene-hopene cyclase N-terminal domain Methyltransf_16 PF10294.9 EMC79180.1 - 4.9e-12 45.9 1.1 7e-05 22.6 0.1 2.3 2 0 0 2 2 2 2 Lysine methyltransferase Methyltransf_23 PF13489.6 EMC79180.1 - 5.9e-07 29.5 0.0 1.1e-06 28.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EMC79180.1 - 8.8e-06 25.4 0.0 3.1e-05 23.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain PrmA PF06325.13 EMC79180.1 - 1.3e-05 24.7 0.0 2.2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EMC79180.1 - 4.5e-05 23.3 0.0 0.17 11.7 0.1 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EMC79180.1 - 0.00019 22.1 0.1 0.00086 20.0 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 EMC79180.1 - 0.011 15.4 0.0 0.022 14.4 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 EMC79180.1 - 0.018 15.7 0.0 0.11 13.3 0.1 2.1 2 0 0 2 2 2 0 Methyltransferase domain Ocnus PF05005.15 EMC79181.1 - 5.6e-31 106.8 0.5 6.1e-31 106.7 0.5 1.0 1 0 0 1 1 1 1 Janus/Ocnus family (Ocnus) Sushi PF00084.20 EMC79182.1 - 1.7e-52 175.8 68.0 1.1e-09 38.7 4.6 7.2 7 0 0 7 7 7 6 Sushi repeat (SCR repeat) Lectin_C PF00059.21 EMC79182.1 - 1.6e-21 77.1 4.4 1.6e-21 77.1 4.4 2.7 3 0 0 3 3 3 1 Lectin C-type domain EGF_2 PF07974.13 EMC79182.1 - 4.3e-05 23.8 12.3 0.00023 21.5 9.4 4.1 2 0 0 2 2 2 1 EGF-like domain EGF PF00008.27 EMC79182.1 - 0.0016 18.7 11.3 0.0016 18.7 11.3 5.1 7 0 0 7 7 7 1 EGF-like domain hEGF PF12661.7 EMC79182.1 - 0.0025 18.4 5.9 0.0025 18.4 5.9 5.2 5 0 0 5 5 5 1 Human growth factor-like EGF EGF_3 PF12947.7 EMC79182.1 - 0.022 14.9 5.0 0.022 14.9 5.0 6.1 6 0 0 6 6 6 0 EGF domain Nuc_recep-AF1 PF11825.8 EMC79183.1 - 3.1e-43 146.4 14.7 5.3e-43 145.7 14.7 1.4 1 0 0 1 1 1 1 Nuclear/hormone receptor activator site AF-1 Hormone_recep PF00104.30 EMC79183.1 - 1.9e-38 132.1 0.0 3.6e-38 131.2 0.0 1.5 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 EMC79183.1 - 4.7e-32 110.3 15.8 7.9e-32 109.5 15.8 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) PBC PF03792.13 EMC79184.1 - 2.3e-66 223.2 0.1 4e-66 222.4 0.0 1.5 2 0 0 2 2 2 1 PBC domain Homeodomain PF00046.29 EMC79184.1 - 9.2e-20 70.3 0.9 2.1e-19 69.1 0.9 1.7 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC79184.1 - 4.8e-16 58.4 0.0 1.1e-15 57.2 0.0 1.7 1 0 0 1 1 1 1 Homeobox KN domain YdaS_antitoxin PF15943.5 EMC79184.1 - 0.0022 17.8 0.0 0.0053 16.6 0.0 1.6 1 0 0 1 1 1 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_3 PF01381.22 EMC79184.1 - 0.0093 16.0 0.0 0.021 14.9 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix Sec15 PF04091.12 EMC79184.1 - 0.011 15.2 0.5 0.016 14.6 0.5 1.3 1 0 0 1 1 1 0 Exocyst complex subunit Sec15-like LZ3wCH PF18517.1 EMC79184.1 - 0.16 12.1 0.0 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 Leucine zipper with capping helix domain NUC130_3NT PF08158.12 EMC79184.1 - 0.5 10.7 1.6 27 5.2 0.1 3.0 3 0 0 3 3 3 0 NUC130/3NT domain Nuf2 PF03800.14 EMC79185.1 - 4e-33 114.5 0.5 4e-33 114.5 0.5 2.7 2 0 0 2 2 2 1 Nuf2 family DHR10 PF18595.1 EMC79185.1 - 0.015 15.3 20.8 0.015 15.3 20.8 4.3 2 1 1 4 4 4 0 Designed helical repeat protein 10 domain DUF5082 PF16888.5 EMC79185.1 - 0.51 10.6 36.0 1.5 9.2 16.9 4.9 2 1 2 4 4 4 0 Domain of unknown function (DUF5082) HMMR_N PF15905.5 EMC79185.1 - 0.87 9.0 68.5 0.14 11.6 28.0 2.1 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal SAVED PF18145.1 EMC79185.1 - 1.2 9.0 4.7 1.1 9.0 0.1 2.7 2 1 0 3 3 3 0 SMODS-associated and fused to various effectors sensor domain ApoLp-III PF07464.11 EMC79185.1 - 2 8.5 35.9 14 5.8 8.7 3.7 1 1 2 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Spc7 PF08317.11 EMC79185.1 - 2.2 7.1 63.7 0.85 8.4 28.3 3.3 1 1 2 3 3 3 0 Spc7 kinetochore protein PMC2NT PF08066.12 EMC79185.1 - 2.9 8.7 6.6 1.2 9.9 0.6 3.3 2 1 0 3 3 3 0 PMC2NT (NUC016) domain LRR_8 PF13855.6 EMC79186.1 - 2.5e-22 78.4 19.9 1.8e-10 40.4 2.3 3.2 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EMC79186.1 - 6.7e-10 39.1 9.5 0.002 18.5 0.5 3.6 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRRNT PF01462.18 EMC79186.1 - 0.00016 21.2 3.1 0.00018 21.1 0.6 2.3 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_5 PF13306.6 EMC79186.1 - 0.0035 17.3 0.0 0.0056 16.6 0.0 1.3 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EMC79186.1 - 0.1 13.2 12.3 0.29 11.8 0.1 5.4 5 1 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.6 EMC79186.1 - 0.1 12.7 14.0 1.6 9.0 0.0 4.8 5 0 0 5 5 5 0 Leucine Rich repeat MAPEG PF01124.18 EMC79187.1 - 8.2e-23 80.7 0.4 1.1e-22 80.4 0.4 1.1 1 0 0 1 1 1 1 MAPEG family Aldedh PF00171.22 EMC79188.1 - 6e-168 559.1 0.0 7.3e-168 558.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family CC PF04942.14 EMC79188.1 - 0.36 11.1 2.4 1.7 8.9 0.1 2.6 2 0 0 2 2 2 0 CC domain EMC3_TMCO1 PF01956.16 EMC79189.1 - 3.6e-43 147.3 1.3 4.2e-43 147.0 1.3 1.0 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like TRAM1 PF08390.11 EMC79189.1 - 0.0017 18.0 0.5 0.0063 16.1 0.0 2.0 2 0 0 2 2 2 1 TRAM1-like protein Vpu PF00558.19 EMC79189.1 - 0.0072 16.1 1.2 0.013 15.2 1.2 1.5 1 1 0 1 1 1 1 Vpu protein DUF4199 PF13858.6 EMC79189.1 - 0.011 16.1 0.1 0.022 15.1 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) DUF2368 PF10166.9 EMC79189.1 - 0.018 14.7 0.1 0.029 14.0 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2368) Connexin PF00029.19 EMC79189.1 - 0.052 13.3 0.2 0.076 12.8 0.2 1.2 1 0 0 1 1 1 0 Connexin DUF4257 PF14074.6 EMC79189.1 - 0.059 13.6 0.6 0.31 11.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4257) DivIC PF04977.15 EMC79189.1 - 0.11 12.3 0.5 0.11 12.3 0.5 2.4 1 1 1 2 2 2 0 Septum formation initiator DUF3899 PF13038.6 EMC79189.1 - 0.12 12.9 0.8 1.4 9.5 0.8 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3899) Nucleoside_tran PF01733.18 EMC79189.1 - 0.15 11.4 3.0 0.13 11.6 1.2 1.7 1 1 1 2 2 2 0 Nucleoside transporter DUF1090 PF06476.12 EMC79189.1 - 0.87 9.7 12.9 1.5 9.0 12.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) XhlA PF10779.9 EMC79189.1 - 1.1 9.5 6.5 6.1 7.1 6.3 2.1 1 1 1 2 2 2 0 Haemolysin XhlA Atg14 PF10186.9 EMC79189.1 - 1.8 7.5 6.6 2.6 7.0 6.6 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 SieB PF14163.6 EMC79189.1 - 4.9 6.6 7.2 16 5.0 5.1 2.5 2 1 0 2 2 2 0 Super-infection exclusion protein B PRK PF00485.18 EMC79190.1 - 3.9e-47 160.5 0.8 4.5e-47 160.3 0.8 1.0 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family DUF826 PF05696.11 EMC79190.1 - 0.1 12.7 0.0 6.6 6.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF826) Cytochrom_C PF00034.21 EMC79191.1 - 2.1e-14 54.4 0.1 2.8e-14 54.0 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 EMC79191.1 - 1.6e-06 28.3 3.4 8.9e-06 25.9 3.4 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 EMC79191.1 - 0.00013 21.7 3.2 0.0013 18.4 3.2 2.3 1 1 0 1 1 1 1 Cytochrome c-550 domain UPF0128 PF03673.13 EMC79191.1 - 0.094 12.2 0.2 0.13 11.7 0.1 1.2 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0128) Hexokinase_1 PF00349.21 EMC79192.1 - 0.0099 15.8 0.1 0.013 15.4 0.1 1.1 1 0 0 1 1 1 1 Hexokinase DUF824 PF05688.11 EMC79192.1 - 0.051 13.4 0.5 1.3 9.0 0.1 2.2 2 0 0 2 2 2 0 Salmonella repeat of unknown function (DUF824) FARP PF01581.16 EMC79192.1 - 3.9 8.4 7.3 78 4.5 0.0 4.1 4 0 0 4 4 4 0 FMRFamide related peptide family bZIP_Maf PF03131.17 EMC79193.1 - 0.0051 17.3 5.4 0.0076 16.7 0.5 2.7 2 1 1 3 3 3 1 bZIP Maf transcription factor RRM_1 PF00076.22 EMC79194.1 - 1.2e-32 111.5 0.0 4.8e-15 55.1 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMC79194.1 - 8.2e-09 35.5 0.1 0.00068 19.7 0.0 2.6 2 2 0 2 2 2 2 RNA recognition motif OB_RNB PF08206.11 EMC79194.1 - 0.033 13.9 0.5 1.2 8.9 0.1 2.7 2 0 0 2 2 2 0 Ribonuclease B OB domain Chromo_shadow PF01393.19 EMC79195.1 - 3.4e-33 113.5 0.1 1.4e-29 101.9 0.0 2.4 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.24 EMC79195.1 - 1.4e-20 72.9 0.1 1.1e-16 60.5 0.1 2.7 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.6 EMC79195.1 - 0.0092 16.1 0.1 0.053 13.7 0.1 2.1 2 0 0 2 2 2 1 Polycomb-like MTF2 factor 2 PX PF00787.24 EMC79196.1 - 1.4e-24 86.3 2.9 1.8e-24 85.9 2.9 1.2 1 0 0 1 1 1 1 PX domain PH PF00169.29 EMC79197.1 - 3.1e-17 63.0 0.6 5.3e-17 62.2 0.6 1.4 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.28 EMC79197.1 - 2.4e-11 43.0 0.3 6.5e-11 41.7 0.3 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC79197.1 - 2.5e-10 39.9 0.1 5.9e-10 38.7 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EMC79197.1 - 3.8e-10 39.4 0.1 9.5e-10 38.2 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain PH_9 PF15410.6 EMC79197.1 - 1.1e-05 25.7 0.3 3.1e-05 24.3 0.3 1.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EMC79197.1 - 5.8e-05 23.5 2.8 5.8e-05 23.5 2.8 2.0 2 1 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 EMC79197.1 - 8.2e-05 22.7 0.1 0.00017 21.6 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 EMC79197.1 - 0.032 14.1 0.1 0.055 13.3 0.1 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain Homeodomain PF00046.29 EMC79198.1 - 4.7e-22 77.6 7.4 6.8e-22 77.1 7.4 1.2 1 0 0 1 1 1 1 Homeodomain YcgR PF07317.12 EMC79198.1 - 0.0026 17.6 0.0 0.026 14.4 0.0 2.0 1 1 1 2 2 2 1 Flagellar regulator YcgR Homeobox_KN PF05920.11 EMC79198.1 - 2.3 8.2 6.9 0.26 11.2 0.6 2.5 3 0 0 3 3 3 0 Homeobox KN domain DUF4074 PF13293.6 EMC79199.1 - 9.5e-36 121.9 8.9 9.5e-36 121.9 8.9 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4074) Homeodomain PF00046.29 EMC79199.1 - 1.4e-21 76.0 5.2 3.1e-21 75.0 5.2 1.6 1 0 0 1 1 1 1 Homeodomain CDC27 PF09507.10 EMC79199.1 - 4.4 6.6 12.7 6.8 6.0 12.7 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Homeodomain PF00046.29 EMC79200.1 - 8.8e-24 83.1 9.2 1.1e-23 82.8 9.2 1.2 1 0 0 1 1 1 1 Homeodomain DUF2209 PF09974.9 EMC79200.1 - 0.0099 16.2 0.1 0.012 16.0 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2209) Homeobox_KN PF05920.11 EMC79200.1 - 0.021 14.7 0.5 0.021 14.7 0.5 1.6 2 0 0 2 2 2 0 Homeobox KN domain Terminase_5 PF06056.12 EMC79200.1 - 0.031 14.1 0.1 0.042 13.7 0.1 1.3 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) HTH_23 PF13384.6 EMC79200.1 - 0.043 13.6 0.9 0.063 13.1 0.9 1.3 1 0 0 1 1 1 0 Homeodomain-like domain Homeodomain PF00046.29 EMC79201.1 - 3.5e-22 78.0 8.4 7.2e-22 77.0 8.4 1.6 1 0 0 1 1 1 1 Homeodomain Terminase_5 PF06056.12 EMC79201.1 - 0.07 13.0 0.2 0.18 11.7 0.2 1.6 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) DUF2209 PF09974.9 EMC79201.1 - 0.08 13.3 0.1 0.12 12.7 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Homeobox_KN PF05920.11 EMC79201.1 - 0.12 12.3 1.6 0.24 11.3 0.8 1.9 2 0 0 2 2 2 0 Homeobox KN domain DUF739 PF05339.11 EMC79201.1 - 0.19 11.9 0.2 0.39 10.9 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF739) SPX PF03105.19 EMC79201.1 - 2.7 7.8 10.6 3.4 7.5 10.6 1.1 1 0 0 1 1 1 0 SPX domain SOG2 PF10428.9 EMC79201.1 - 4.9 6.2 16.0 6.3 5.9 16.0 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Homeodomain PF00046.29 EMC79202.1 - 1.7e-21 75.8 9.1 1.7e-21 75.8 9.1 1.7 2 0 0 2 2 2 1 Homeodomain Homeodomain PF00046.29 EMC79203.1 - 8.1e-22 76.8 8.5 1.3e-21 76.2 8.5 1.3 1 0 0 1 1 1 1 Homeodomain DUF2209 PF09974.9 EMC79203.1 - 0.18 12.1 0.1 0.29 11.5 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Homeodomain PF00046.29 EMC79204.1 - 7.3e-22 77.0 6.7 8.9e-22 76.7 6.7 1.1 1 0 0 1 1 1 1 Homeodomain HTH_23 PF13384.6 EMC79204.1 - 0.0054 16.5 0.0 0.0088 15.8 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain CI-B14_5a PF07347.12 EMC79204.1 - 0.046 13.6 0.1 0.068 13.1 0.1 1.3 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) Homeobox_KN PF05920.11 EMC79204.1 - 0.055 13.4 1.2 0.086 12.8 1.0 1.6 1 1 0 1 1 1 0 Homeobox KN domain Homeodomain PF00046.29 EMC79205.1 - 4e-20 71.4 6.3 7.3e-20 70.6 6.3 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC79205.1 - 0.06 13.3 0.3 0.14 12.1 0.3 1.6 1 0 0 1 1 1 0 Homeobox KN domain Homeodomain PF00046.29 EMC79206.1 - 1.1e-19 70.0 8.0 1.3e-19 69.8 8.0 1.0 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC79206.1 - 4.2e-05 23.3 2.6 5.6e-05 22.9 2.5 1.4 1 1 0 1 1 1 1 Homeobox KN domain DUF1510 PF07423.11 EMC79206.1 - 0.012 15.8 0.1 0.012 15.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1510) CI-B14_5a PF07347.12 EMC79206.1 - 0.017 15.0 0.3 0.021 14.7 0.3 1.1 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) Homez PF11569.8 EMC79206.1 - 0.066 12.7 0.1 0.071 12.6 0.1 1.2 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez HIRA_B PF09453.10 EMC79206.1 - 7.8 6.5 7.8 0.36 10.7 0.7 2.4 2 0 0 2 2 2 0 HIRA B motif Homeodomain PF00046.29 EMC79207.1 - 3.3e-21 74.9 4.9 5.4e-21 74.2 4.9 1.4 1 0 0 1 1 1 1 Homeodomain NAD_binding_2 PF03446.15 EMC79208.1 - 3.6e-51 173.5 0.3 5.1e-51 173.0 0.3 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EMC79208.1 - 4.8e-33 114.0 0.0 7.8e-33 113.3 0.0 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 2-Hacid_dh_C PF02826.19 EMC79208.1 - 1e-09 38.0 0.0 1.7e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EMC79208.1 - 5.4e-08 33.3 0.0 1.5e-07 31.9 0.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 EMC79208.1 - 0.00023 21.1 0.0 0.00044 20.2 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PDH PF02153.17 EMC79208.1 - 0.00078 18.5 0.2 0.0011 18.0 0.2 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase IlvN PF07991.12 EMC79208.1 - 0.0053 16.4 0.1 0.0096 15.5 0.1 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 EMC79208.1 - 0.0088 16.3 0.1 0.027 14.7 0.0 2.0 2 1 0 2 2 2 1 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 EMC79208.1 - 0.017 14.7 0.1 1.3 8.6 0.0 2.2 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Sacchrp_dh_NADP PF03435.18 EMC79208.1 - 0.12 12.7 0.0 0.74 10.1 0.0 2.0 1 1 1 2 2 2 0 Saccharopine dehydrogenase NADP binding domain zf-C2H2_aberr PF17017.5 EMC79209.1 - 8.6e-07 29.3 2.7 6.2e-05 23.2 0.2 2.2 1 1 1 2 2 2 2 Aberrant zinc-finger zf-C2H2_4 PF13894.6 EMC79209.1 - 0.0017 19.1 6.3 0.54 11.3 2.2 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC79209.1 - 0.012 16.0 6.8 0.68 10.5 2.3 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf_C2H2_ZHX PF18387.1 EMC79209.1 - 0.16 11.6 0.1 0.75 9.5 0.0 2.0 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain ARS2 PF04959.13 EMC79209.1 - 0.21 12.0 4.5 9.5 6.5 0.4 2.8 1 1 2 3 3 3 0 Arsenite-resistance protein 2 Mab-21 PF03281.14 EMC79210.1 - 2.1e-33 115.9 0.2 2.8e-33 115.5 0.2 1.2 1 0 0 1 1 1 1 Mab-21 protein PIN_11 PF18479.1 EMC79210.1 - 0.1 12.8 0.1 3.7 7.7 0.0 3.0 3 0 0 3 3 3 0 PIN like domain CCDC50_N PF15295.6 EMC79211.1 - 1.7e-45 154.3 39.6 9.1e-40 135.7 24.2 2.3 2 0 0 2 2 2 2 Coiled-coil domain-containing protein 50 N-terminus SspO PF08175.12 EMC79211.1 - 2.8 8.5 9.7 2.2 8.8 5.3 2.9 1 1 1 2 2 2 0 Small acid-soluble spore protein O family Urotensin_II PF02083.15 EMC79212.1 - 0.00013 21.4 4.8 0.00022 20.7 4.8 1.4 1 0 0 1 1 1 1 Urotensin II Dynactin_p22 PF07426.11 EMC79212.1 - 0.0013 18.6 1.7 0.47 10.3 0.2 2.1 2 0 0 2 2 2 2 Dynactin subunit p22 Musclin PF11037.8 EMC79213.1 - 9.7e-62 206.8 0.1 1.1e-61 206.6 0.1 1.0 1 0 0 1 1 1 1 Insulin-resistance promoting peptide in skeletal muscle ANP PF00212.18 EMC79213.1 - 0.00093 19.3 3.2 0.77 10.0 0.3 2.4 2 0 0 2 2 2 2 Atrial natriuretic peptide TIR PF01582.20 EMC79214.1 - 4.4e-07 29.9 0.0 6e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 TIR domain TMEM52 PF14979.6 EMC79215.1 - 9e-05 22.4 12.4 0.00047 20.1 12.4 1.9 1 1 0 1 1 1 1 Transmembrane 52 Hum_adeno_E3A PF05393.11 EMC79215.1 - 0.036 14.1 2.3 0.056 13.4 2.3 1.3 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein TMIE PF16038.5 EMC79215.1 - 0.4 10.5 3.2 0.6 10.0 3.2 1.2 1 0 0 1 1 1 0 TMIE protein WBP-1 PF11669.8 EMC79215.1 - 0.44 11.2 9.9 2.7 8.7 9.9 2.0 1 1 0 1 1 1 0 WW domain-binding protein 1 PMP22_Claudin PF00822.20 EMC79216.1 - 3.2e-19 69.4 7.9 4.4e-19 69.0 7.9 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC79216.1 - 2.8e-07 30.5 12.8 1.3e-06 28.3 12.8 1.9 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DuoxA PF10204.9 EMC79216.1 - 0.31 10.0 7.4 0.018 14.0 2.6 1.5 2 0 0 2 2 2 0 Dual oxidase maturation factor Phage_holin_3_6 PF07332.11 EMC79216.1 - 2.1 8.4 9.0 1 9.4 2.2 2.8 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III PMP22_Claudin PF00822.20 EMC79217.1 - 1.1e-50 171.7 10.2 1.3e-50 171.5 10.2 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC79217.1 - 9.8e-13 48.3 11.3 4.1e-12 46.3 10.9 2.0 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Sbt_1 PF05982.12 EMC79217.1 - 0.0034 16.7 1.9 0.0042 16.4 1.9 1.3 1 0 0 1 1 1 1 Na+-dependent bicarbonate transporter superfamily ThrE PF06738.12 EMC79217.1 - 0.0086 15.5 2.1 0.0086 15.5 2.1 2.0 2 1 1 3 3 3 1 Putative threonine/serine exporter Amastin PF07344.11 EMC79217.1 - 0.013 15.3 8.1 0.008 16.0 6.6 1.4 1 1 0 1 1 1 0 Amastin surface glycoprotein SUR7 PF06687.12 EMC79217.1 - 0.018 14.7 6.2 0.046 13.3 6.1 1.8 1 1 0 1 1 1 0 SUR7/PalI family CD20 PF04103.15 EMC79217.1 - 0.018 15.1 1.1 0.018 15.1 1.1 2.5 2 1 1 3 3 3 0 CD20-like family TMEM37 PF15108.6 EMC79217.1 - 0.043 13.7 5.7 0.037 13.9 4.3 1.5 1 1 0 1 1 1 0 Voltage-dependent calcium channel gamma-like subunit protein family DUF1218 PF06749.12 EMC79217.1 - 0.14 12.6 8.7 0.19 12.3 2.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1218) L6_membrane PF05805.12 EMC79217.1 - 0.25 10.9 9.9 0.79 9.3 8.6 2.1 1 1 1 2 2 2 0 L6 membrane protein DUF4134 PF13572.6 EMC79217.1 - 0.28 11.5 6.2 0.1 12.9 3.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4134) DUF2157 PF09925.9 EMC79217.1 - 0.42 10.4 0.1 0.42 10.4 0.1 3.1 3 1 0 4 4 4 0 Predicted membrane protein (DUF2157) OppC_N PF12911.7 EMC79217.1 - 0.48 10.4 0.0 0.48 10.4 0.0 2.7 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C DUF4064 PF13273.6 EMC79217.1 - 0.61 10.4 19.2 0.14 12.4 11.8 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) 2OG-FeII_Oxy_3 PF13640.6 EMC79219.1 - 3.8e-11 43.7 0.0 1.9e-10 41.5 0.0 2.2 2 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 EMC79219.1 - 2.9e-09 37.3 0.0 1.8e-08 34.8 0.0 2.3 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Fis1_TPR_C PF14853.6 EMC79219.1 - 0.0022 18.1 1.0 0.01 15.9 0.1 2.4 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat YfiO PF13525.6 EMC79219.1 - 0.0053 16.5 5.0 0.11 12.2 0.2 3.0 3 0 0 3 3 3 1 Outer membrane lipoprotein TPR_2 PF07719.17 EMC79219.1 - 0.006 16.6 6.4 1.1 9.5 0.5 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMC79219.1 - 0.01 15.6 6.5 0.66 9.9 0.2 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EMC79219.1 - 0.028 14.4 4.0 7.7 6.8 0.4 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Oxygenase-NA PF09859.9 EMC79219.1 - 0.037 13.6 0.0 0.51 9.8 0.0 2.3 1 1 0 1 1 1 0 Oxygenase, catalysing oxidative methylation of damaged DNA TPR_14 PF13428.6 EMC79219.1 - 0.063 14.1 0.6 2.1 9.4 0.1 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat FAD_binding_9 PF08021.11 EMC79219.1 - 0.098 12.9 0.1 0.19 11.9 0.1 1.4 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain TPR_9 PF13371.6 EMC79219.1 - 0.1 12.8 0.3 0.69 10.1 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 EMC79219.1 - 4.3 7.7 6.1 3.3 8.1 0.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat P53 PF00870.18 EMC79220.1 - 2.8e-65 219.7 1.2 2.9e-65 219.7 0.0 1.6 2 0 0 2 2 2 1 P53 DNA-binding domain P53_tetramer PF07710.11 EMC79220.1 - 6.8e-19 66.9 0.4 1.9e-18 65.5 0.2 1.8 2 0 0 2 2 2 1 P53 tetramerisation motif SAM_2 PF07647.17 EMC79220.1 - 4.5e-10 39.5 0.0 8.5e-10 38.6 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EMC79220.1 - 0.024 15.0 0.0 0.065 13.7 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF2357 PF09823.9 EMC79220.1 - 0.17 11.1 2.4 0.42 9.8 2.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2357) LIM PF00412.22 EMC79221.1 - 1.3e-34 118.2 28.1 1.2e-13 51.1 6.9 3.3 3 0 0 3 3 3 3 LIM domain Mut7-C PF01927.16 EMC79221.1 - 5.6 7.1 17.8 0.25 11.4 0.7 3.7 2 1 0 3 3 3 0 Mut7-C RNAse domain BTB PF00651.31 EMC79222.1 - 2e-27 95.6 0.3 3.5e-27 94.8 0.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 EMC79222.1 - 9.5e-23 79.6 54.2 8.3e-07 29.2 0.5 7.0 8 0 0 8 8 7 5 Zinc-finger double domain zf-C2H2 PF00096.26 EMC79222.1 - 4.4e-18 64.6 58.3 3.7e-05 23.9 0.3 7.6 7 0 0 7 7 6 6 Zinc finger, C2H2 type zf-met PF12874.7 EMC79222.1 - 2.7e-11 43.4 30.9 0.0081 16.5 0.1 7.1 6 0 0 6 6 6 5 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EMC79222.1 - 7.5e-11 41.9 56.4 0.012 16.4 1.1 7.7 7 0 0 7 7 6 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC79222.1 - 4e-05 23.8 20.5 0.41 11.0 2.0 6.3 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding DZR PF12773.7 EMC79222.1 - 0.00011 22.2 23.7 0.44 10.6 4.3 4.8 4 0 0 4 4 4 3 Double zinc ribbon zf-H2C2_5 PF13909.6 EMC79222.1 - 0.021 14.6 0.9 0.021 14.6 0.9 7.3 6 2 0 6 6 6 0 C2H2-type zinc-finger domain DUF3342 PF11822.8 EMC79222.1 - 0.031 14.5 0.4 0.073 13.3 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Zn-ribbon_8 PF09723.10 EMC79222.1 - 0.032 14.3 1.3 0.032 14.3 1.3 5.8 4 3 3 7 7 7 0 Zinc ribbon domain zf-C2H2_6 PF13912.6 EMC79222.1 - 0.039 14.0 0.1 0.039 14.0 0.1 6.5 7 0 0 7 7 6 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EMC79222.1 - 0.081 12.7 0.3 0.081 12.7 0.3 6.4 7 0 0 7 7 6 0 zinc-finger C2H2-type zf-C2HE PF16278.5 EMC79222.1 - 0.09 13.2 38.1 0.19 12.2 0.3 6.9 1 1 6 7 7 7 0 C2HE / C2H2 / C2HC zinc-binding finger DUF3268 PF11672.8 EMC79222.1 - 0.77 10.1 14.1 1 9.7 0.3 4.0 3 1 1 4 4 4 0 zinc-finger-containing domain GAGA PF09237.11 EMC79222.1 - 1.3 8.9 17.2 7.2 6.5 0.0 5.1 1 1 4 5 5 5 0 GAGA factor Somatostatin PF03002.15 EMC79223.1 - 1.1e-12 47.6 8.4 1.5e-12 47.2 8.4 1.2 1 0 0 1 1 1 1 Somatostatin/Cortistatin family DUF4363 PF14276.6 EMC79224.1 - 0.074 13.2 0.1 0.074 13.2 0.1 2.4 2 1 0 3 3 3 0 Domain of unknown function (DUF4363) Trypsin PF00089.26 EMC79225.1 - 7.5e-57 192.7 0.0 1.1e-56 192.1 0.0 1.3 1 0 0 1 1 1 1 Trypsin CUB PF00431.20 EMC79225.1 - 2.6e-50 169.4 1.0 5.9e-29 100.6 0.1 2.6 2 0 0 2 2 2 2 CUB domain Sushi PF00084.20 EMC79225.1 - 3.6e-16 59.5 19.3 2.3e-09 37.7 0.3 4.7 5 0 0 5 5 5 2 Sushi repeat (SCR repeat) FXa_inhibition PF14670.6 EMC79225.1 - 1e-08 35.3 10.8 5.7e-08 32.9 8.4 3.0 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site CUB_2 PF02408.20 EMC79225.1 - 7.1e-06 25.8 0.2 0.018 14.8 0.0 2.9 3 0 0 3 3 3 2 CUB-like domain EGF_CA PF07645.15 EMC79225.1 - 2.8e-05 24.2 7.9 2.8e-05 24.2 7.9 2.6 3 0 0 3 3 3 1 Calcium-binding EGF domain Trypsin_2 PF13365.6 EMC79225.1 - 0.00013 22.9 0.1 0.00026 21.9 0.1 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain cEGF PF12662.7 EMC79225.1 - 0.00043 20.1 6.5 0.0042 17.0 3.9 3.1 2 0 0 2 2 2 1 Complement Clr-like EGF-like DUF1986 PF09342.11 EMC79225.1 - 0.027 14.8 0.1 0.063 13.7 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) HRM PF02793.22 EMC79225.1 - 0.041 14.2 2.2 7.3 7.0 0.2 2.7 2 0 0 2 2 2 0 Hormone receptor domain DUF2244 PF10003.9 EMC79225.1 - 0.21 11.3 0.1 0.36 10.5 0.1 1.3 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) V-set PF07686.17 EMC79226.1 - 8.8e-11 42.0 0.0 1.3e-10 41.4 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC79226.1 - 8.2e-05 23.1 0.0 0.0002 21.9 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC79226.1 - 0.00098 19.3 0.0 0.0018 18.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC79226.1 - 0.0024 17.9 0.0 0.005 16.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC79226.1 - 0.018 15.4 1.4 0.042 14.2 1.4 1.6 1 1 0 1 1 1 0 Immunoglobulin domain Tctex-1 PF03645.13 EMC79227.1 - 1.1e-25 89.8 0.0 1.3e-25 89.7 0.0 1.0 1 0 0 1 1 1 1 Tctex-1 family CTP_transf_like PF01467.26 EMC79228.1 - 5.7e-32 110.9 0.5 1.2e-31 109.9 0.0 1.7 2 0 0 2 2 2 1 Cytidylyltransferase-like DUF1664 PF07889.12 EMC79228.1 - 0.056 13.5 0.6 0.092 12.8 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) KH_5 PF13184.6 EMC79228.1 - 0.058 13.5 0.5 0.16 12.0 0.5 1.7 1 0 0 1 1 1 0 NusA-like KH domain YtxH PF12732.7 EMC79228.1 - 0.24 11.9 2.5 0.46 11.1 2.5 1.4 1 0 0 1 1 1 0 YtxH-like protein AKNA PF12443.8 EMC79228.1 - 0.35 11.5 2.5 0.54 11.0 0.8 2.0 2 0 0 2 2 2 0 AT-hook-containing transcription factor DUF3678 PF12435.8 EMC79228.1 - 2.4 7.6 6.2 0.81 9.1 2.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) Solute_trans_a PF03619.16 EMC79229.1 - 2.8e-40 138.5 14.9 3.3e-40 138.3 14.9 1.0 1 0 0 1 1 1 1 Organic solute transporter Ostalpha YmcE_antitoxin PF15939.5 EMC79229.1 - 0.2 11.8 3.2 0.61 10.3 3.2 1.8 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system Peptidase_M28 PF04389.17 EMC79230.1 - 9e-14 51.6 0.0 1.8e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 TFR_dimer PF04253.15 EMC79230.1 - 3.7e-09 36.7 0.3 9.8e-09 35.4 0.1 1.8 2 0 0 2 2 2 1 Transferrin receptor-like dimerisation domain PA PF02225.22 EMC79230.1 - 5.5e-07 29.5 0.0 2e-06 27.7 0.0 1.9 2 0 0 2 2 2 1 PA domain Pkinase_Tyr PF07714.17 EMC79231.1 - 1.3e-88 296.7 0.0 1.7e-88 296.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC79231.1 - 1.1e-43 149.5 0.0 3.6e-43 147.9 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain GTPase_binding PF09027.10 EMC79231.1 - 4.2e-43 145.2 0.7 8.9e-43 144.1 0.7 1.6 1 0 0 1 1 1 1 GTPase binding Inhibitor_Mig-6 PF11555.8 EMC79231.1 - 4.1e-33 113.3 11.1 4.1e-33 113.3 11.1 4.1 4 0 0 4 4 2 1 EGFR receptor inhibitor Mig-6 SH3_9 PF14604.6 EMC79231.1 - 1.8e-09 37.3 0.0 3.8e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain UBA_4 PF14555.6 EMC79231.1 - 4.6e-07 29.5 0.0 0.0082 15.9 0.0 2.5 2 0 0 2 2 2 2 UBA-like domain SH3_1 PF00018.28 EMC79231.1 - 8.6e-07 28.5 0.0 1.6e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 SH3 domain Kinase-like PF14531.6 EMC79231.1 - 2.3e-05 23.8 0.0 3.9e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like SH3_2 PF07653.17 EMC79231.1 - 0.00033 20.3 0.0 0.00087 18.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Haspin_kinase PF12330.8 EMC79231.1 - 0.018 14.0 0.0 0.03 13.3 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain UBA PF00627.31 EMC79231.1 - 0.07 13.1 0.0 0.24 11.4 0.0 1.9 2 0 0 2 2 2 0 UBA/TS-N domain TAP_C PF03943.13 EMC79231.1 - 0.17 11.6 0.1 8.1 6.2 0.0 2.8 2 0 0 2 2 2 0 TAP C-terminal domain PCuAC PF04314.13 EMC79232.1 - 0.0012 18.6 0.1 10 6.0 0.0 4.0 1 1 2 4 4 4 2 Copper chaperone PCu(A)C Cadherin_3 PF16184.5 EMC79232.1 - 0.065 13.2 1.3 22 5.1 0.0 4.3 2 2 4 6 6 6 0 Cadherin-like DUF2345 PF10106.9 EMC79232.1 - 0.75 9.7 58.3 0.42 10.5 2.8 5.7 1 1 3 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2345) VWD PF00094.25 EMC79233.1 - 3.7e-19 69.5 0.0 7.2e-19 68.6 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type D domain NIDO PF06119.14 EMC79233.1 - 2.7e-08 34.7 0.0 9.1e-08 33.0 0.0 2.0 1 0 0 1 1 1 1 Nidogen-like Viral_Rep PF02407.16 EMC79233.1 - 0.092 13.0 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Putative viral replication protein DDE_3 PF13358.6 EMC79233.1 - 0.2 11.4 0.0 0.37 10.5 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease zf_CCCH_4 PF18345.1 EMC79233.1 - 0.88 9.7 7.0 1.2 9.2 0.2 2.9 2 0 0 2 2 2 0 Zinc finger domain NIDO PF06119.14 EMC79235.1 - 3.5e-10 40.7 0.7 6.7e-10 39.8 0.7 1.5 1 0 0 1 1 1 1 Nidogen-like DNA_photolyase PF00875.18 EMC79236.1 - 2.3e-21 76.5 0.0 4.2e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 DNA photolyase FAD_binding_7 PF03441.14 EMC79236.1 - 0.024 14.1 0.8 0.068 12.6 0.2 1.9 2 0 0 2 2 2 0 FAD binding domain of DNA photolyase zf-RING_9 PF13901.6 EMC79238.1 - 2e-70 237.0 14.7 2e-70 237.0 14.7 2.3 2 0 0 2 2 2 1 Putative zinc-RING and/or ribbon RUN PF02759.19 EMC79238.1 - 3.6e-09 36.7 0.2 8.6e-09 35.5 0.2 1.6 1 0 0 1 1 1 1 RUN domain FYTT PF07078.11 EMC79239.1 - 3.7e-120 401.0 19.5 4.2e-120 400.8 19.5 1.0 1 0 0 1 1 1 1 Forty-two-three protein LRR_8 PF13855.6 EMC79240.1 - 2.6e-22 78.3 10.3 6.5e-08 32.2 0.4 3.4 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EMC79240.1 - 4.2e-17 62.0 18.7 0.00012 22.4 0.1 5.1 3 2 2 5 5 5 5 Leucine Rich repeats (2 copies) CH PF00307.31 EMC79240.1 - 9.1e-10 38.7 0.0 1.9e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain LRR_6 PF13516.6 EMC79240.1 - 0.001 19.0 13.0 0.63 10.2 0.0 5.6 5 0 0 5 5 5 2 Leucine Rich repeat CAMSAP_CH PF11971.8 EMC79240.1 - 0.018 14.9 0.0 0.056 13.3 0.0 1.8 1 0 0 1 1 1 0 CAMSAP CH domain LRR_1 PF00560.33 EMC79240.1 - 0.051 14.1 23.3 30 5.7 0.7 7.9 9 0 0 9 9 9 0 Leucine Rich Repeat LRR_9 PF14580.6 EMC79240.1 - 3.2 7.2 6.1 7.6 6.0 2.7 2.7 1 1 2 3 3 3 0 Leucine-rich repeat IQ PF00612.27 EMC79241.1 - 0.00016 21.2 0.2 0.00016 21.2 0.2 2.4 3 0 0 3 3 3 1 IQ calmodulin-binding motif Baculo_PEP_C PF04513.12 EMC79241.1 - 0.013 15.6 7.3 0.038 14.0 1.1 2.4 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus APG6_N PF17675.1 EMC79241.1 - 0.49 10.9 45.7 25 5.4 15.6 3.4 1 1 1 2 2 2 0 Apg6 coiled-coil region ApoO PF09769.9 EMC79241.1 - 1.4 8.8 7.9 29 4.6 3.1 3.3 1 1 1 2 2 2 0 Apolipoprotein O Fib_alpha PF08702.10 EMC79241.1 - 3.6 7.8 26.6 1 9.6 9.3 3.4 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Ribosomal_L35Ae PF01247.18 EMC79242.1 - 2e-46 156.1 0.4 2.2e-46 155.9 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae DUF2080 PF09853.9 EMC79242.1 - 0.027 14.2 0.3 0.12 12.1 0.0 2.2 2 1 0 2 2 2 0 Putative transposon-encoded protein (DUF2080) RimM PF01782.18 EMC79242.1 - 0.091 13.0 0.1 1.1 9.5 0.0 2.1 2 0 0 2 2 2 0 RimM N-terminal domain DUF4630 PF15443.6 EMC79243.1 - 0.001 19.3 0.0 0.0014 18.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4630) RPN2_C PF18004.1 EMC79244.1 - 1.3e-49 168.1 11.2 2.8e-49 167.1 11.2 1.5 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 EMC79244.1 - 1.3e-42 142.1 19.5 5.1e-09 36.1 0.0 7.9 7 0 0 7 7 7 7 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EMC79244.1 - 2.3e-21 76.0 0.4 1.3e-14 54.4 0.0 5.5 4 1 1 6 6 6 2 HEAT repeats RPN1_RPN2_N PF17781.1 EMC79244.1 - 1.1e-08 34.9 0.1 3e-08 33.4 0.1 1.8 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain HEAT PF02985.22 EMC79244.1 - 7.2e-06 25.8 1.0 1.3 9.5 0.0 5.4 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.6 EMC79244.1 - 0.00047 20.6 1.5 0.52 10.9 0.0 5.0 5 1 2 7 7 6 2 HEAT-like repeat HEAT_PBS PF03130.16 EMC79244.1 - 0.0018 18.8 1.6 6.7 7.7 0.0 4.6 4 0 0 4 4 3 1 PBS lyase HEAT-like repeat PA26 PF04636.13 EMC79244.1 - 0.069 12.1 0.1 0.11 11.4 0.1 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Tim54 PF11711.8 EMC79244.1 - 0.67 8.7 8.9 1.1 8.0 8.9 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Pox_Ag35 PF03286.14 EMC79244.1 - 1.9 8.2 13.2 4.1 7.1 13.2 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Vfa1 PF08432.10 EMC79244.1 - 4.2 7.7 14.9 3.5 7.9 12.0 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 NARP1 PF12569.8 EMC79244.1 - 4.4 6.1 11.4 10 4.9 11.4 1.5 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF1764 PF08576.10 EMC79244.1 - 4.9 8.1 14.3 11 7.0 14.3 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) 7tm_1 PF00001.21 EMC79245.1 - 2e-65 220.8 12.7 2.9e-65 220.2 12.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC79245.1 - 2.6e-12 46.7 13.0 8.5e-12 45.0 13.0 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC79245.1 - 2.8e-07 30.6 8.1 3.5e-07 30.2 4.7 2.2 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC79245.1 - 5.1e-06 26.3 11.5 5.1e-06 26.3 11.5 2.3 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF2385 PF09539.10 EMC79245.1 - 0.029 14.9 0.0 0.06 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2385) DUF1385 PF07136.11 EMC79245.1 - 0.11 11.8 0.1 0.11 11.8 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1385) FOP_dimer PF09398.10 EMC79246.1 - 0.0065 16.7 0.0 0.044 14.0 0.0 2.4 2 0 0 2 2 2 1 FOP N terminal dimerisation domain CENP-B_dimeris PF09026.10 EMC79246.1 - 0.0071 16.7 3.3 0.0071 16.7 3.3 2.2 2 0 0 2 2 2 1 Centromere protein B dimerisation domain Galactosyl_T PF01762.21 EMC79247.1 - 2.9e-49 167.5 0.0 4.2e-49 167.0 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 EMC79247.1 - 2e-08 34.0 0.0 6.3e-08 32.4 0.0 1.7 2 0 0 2 2 2 1 Fringe-like DUF604 PF04646.12 EMC79247.1 - 0.14 11.6 0.0 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF604 RRM_1 PF00076.22 EMC79248.1 - 2.9e-64 212.8 8.8 3.2e-17 62.1 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 EMC79248.1 - 0.00041 20.2 0.5 0.16 11.8 0.0 4.0 3 1 0 4 4 4 1 Rrp7 RRM-like N-terminal domain Limkain-b1 PF11608.8 EMC79248.1 - 0.001 19.1 1.5 1.8 8.7 0.0 3.8 4 0 0 4 4 4 1 Limkain b1 RRM_7 PF16367.5 EMC79248.1 - 0.0016 18.5 0.3 5.2 7.3 0.0 4.0 4 1 0 4 4 4 1 RNA recognition motif DbpA PF03880.15 EMC79248.1 - 0.011 15.7 0.2 0.65 10.0 0.0 3.3 4 0 0 4 4 4 0 DbpA RNA binding domain SET_assoc PF11767.8 EMC79248.1 - 0.024 14.3 0.0 5.9 6.6 0.0 3.0 4 0 0 4 4 4 0 Histone lysine methyltransferase SET associated RRM_occluded PF16842.5 EMC79248.1 - 0.06 13.2 0.3 3 7.8 0.0 2.8 3 0 0 3 3 3 0 Occluded RNA-recognition motif RRM_5 PF13893.6 EMC79248.1 - 0.067 12.8 0.2 5.1 6.7 0.0 3.1 2 1 1 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EMC79248.1 - 0.082 12.9 0.1 2.9 8.0 0.1 3.3 4 0 0 4 4 4 0 Nup53/35/40-type RNA recognition motif SDA1 PF05285.12 EMC79248.1 - 9.4 5.6 81.7 0.037 13.5 49.6 2.6 1 1 1 2 2 2 0 SDA1 7tm_1 PF00001.21 EMC79249.1 - 2.2e-53 181.3 12.4 2.2e-53 181.3 12.4 1.3 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC79249.1 - 6.9e-09 35.5 14.7 1.9e-08 34.0 14.7 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 EMC79249.1 - 3.1e-08 33.3 17.3 1.8e-06 27.5 17.3 2.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.6 EMC79249.1 - 1.9e-05 24.6 6.7 1.9e-05 24.6 6.7 2.2 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC79249.1 - 0.0009 18.9 20.7 0.0029 17.3 19.2 2.2 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx GMP_PDE_delta PF05351.11 EMC79254.1 - 6.1e-44 149.9 0.1 1e-43 149.1 0.1 1.3 1 1 0 1 1 1 1 GMP-PDE, delta subunit CSN7a_helixI PF18392.1 EMC79255.1 - 5.6e-23 80.6 2.6 1.1e-22 79.7 2.6 1.5 1 0 0 1 1 1 1 COP9 signalosome complex subunit 7a helix I domain PCI PF01399.27 EMC79255.1 - 7.4e-09 36.1 4.2 1.7e-08 34.9 0.4 2.3 2 1 0 2 2 2 1 PCI domain Band_3_cyto PF07565.13 EMC79255.1 - 0.028 14.2 5.3 0.055 13.3 5.3 1.4 1 1 0 1 1 1 0 Band 3 cytoplasmic domain RNB PF00773.19 EMC79256.1 - 2.3e-65 221.1 0.0 2.8e-65 220.8 0.0 1.1 1 0 0 1 1 1 1 RNB domain Dis3l2_C_term PF17877.1 EMC79256.1 - 2e-26 92.1 0.0 3.6e-26 91.3 0.0 1.5 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal Rrp44_S1 PF17215.3 EMC79256.1 - 0.19 11.7 0.0 0.43 10.6 0.0 1.6 1 0 0 1 1 1 0 S1 domain Alk_phosphatase PF00245.20 EMC79257.1 - 8.4e-158 525.7 0.0 9.6e-158 525.5 0.0 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 EMC79257.1 - 0.047 13.0 0.1 0.084 12.2 0.1 1.3 1 0 0 1 1 1 0 Metalloenzyme superfamily Alk_phosphatase PF00245.20 EMC79258.1 - 1.5e-162 541.3 0.2 1.7e-162 541.1 0.2 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 EMC79258.1 - 0.012 15.0 0.1 0.023 14.1 0.1 1.4 1 0 0 1 1 1 0 Metalloenzyme superfamily Peptidase_M13_N PF05649.13 EMC79259.1 - 9.4e-79 265.8 0.7 1.5e-78 265.1 0.7 1.3 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 EMC79259.1 - 1.9e-71 239.9 0.3 3.3e-71 239.2 0.3 1.4 1 0 0 1 1 1 1 Peptidase family M13 Efg1 PF10153.9 EMC79259.1 - 0.11 12.9 0.6 0.51 10.7 0.1 2.2 2 0 0 2 2 2 0 rRNA-processing protein Efg1 SLC12 PF03522.15 EMC79260.1 - 0.0013 17.9 0.0 0.0024 17.0 0.0 1.5 2 0 0 2 2 2 1 Solute carrier family 12 AA_permease PF00324.21 EMC79261.1 - 3.5e-71 240.2 23.2 3.5e-71 240.2 23.2 1.9 1 1 1 2 2 2 2 Amino acid permease SLC12 PF03522.15 EMC79261.1 - 0.00011 21.4 0.0 0.00014 21.1 0.0 1.1 1 0 0 1 1 1 1 Solute carrier family 12 Trypsin PF00089.26 EMC79262.1 - 7e-73 245.1 0.0 8e-73 244.9 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EMC79262.1 - 6.8e-10 40.0 0.3 1.4e-09 39.1 0.3 1.4 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 EMC79262.1 - 4.7e-09 36.6 0.0 1e-08 35.6 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Neur_chan_memb PF02932.16 EMC79263.1 - 4.7e-75 252.7 0.2 6.2e-75 252.3 0.2 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 EMC79263.1 - 4.3e-66 222.4 0.3 5.7e-66 222.1 0.3 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain CrgA PF06781.12 EMC79263.1 - 0.29 11.2 2.2 5.2 7.2 0.0 2.9 3 0 0 3 3 3 0 Cell division protein CrgA IF4E PF01652.18 EMC79264.1 - 3.1e-60 202.6 0.1 3.9e-60 202.3 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E p450 PF00067.22 EMC79265.1 - 5.1e-119 398.0 0.0 5.9e-119 397.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EMC79266.1 - 2.4e-125 418.9 0.3 2.7e-125 418.7 0.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EMC79267.1 - 7.8e-106 354.6 0.0 8.9e-106 354.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sec62 PF03839.16 EMC79268.1 - 3.9e-77 258.6 3.2 3.9e-77 258.6 3.2 2.4 1 1 1 2 2 2 1 Translocation protein Sec62 PPP4R2 PF09184.11 EMC79268.1 - 0.005 16.5 9.1 0.005 16.5 9.1 2.4 2 0 0 2 2 2 1 PPP4R2 DEP PF00610.21 EMC79268.1 - 0.011 15.8 0.2 0.03 14.4 0.0 1.8 2 0 0 2 2 2 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Ctr PF04145.15 EMC79268.1 - 0.36 11.4 0.0 0.36 11.4 0.0 2.7 2 1 0 2 2 2 0 Ctr copper transporter family Dsh_C PF12316.8 EMC79268.1 - 4.4 7.6 18.3 11 6.3 10.7 2.3 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal SAM_1 PF00536.30 EMC79269.1 - 4e-12 46.4 0.0 7.9e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC79269.1 - 9.5e-09 35.2 0.0 2.1e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) LRR_4 PF12799.7 EMC79270.1 - 2.9e-19 68.8 37.1 0.0053 17.2 2.1 9.3 3 1 9 12 12 12 12 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EMC79270.1 - 9.1e-14 50.3 33.8 0.047 13.8 0.0 13.7 14 0 0 14 14 14 6 Leucine Rich repeat LRR_1 PF00560.33 EMC79270.1 - 8.6e-11 40.8 33.6 3.5 8.5 0.1 13.8 14 1 0 14 14 14 4 Leucine Rich Repeat LRR_8 PF13855.6 EMC79270.1 - 6.5e-07 29.0 41.0 0.019 14.7 3.0 10.0 5 3 2 8 8 8 6 Leucine rich repeat zf-H2C2_2 PF13465.6 EMC79271.1 - 9.6e-54 177.5 45.5 2.3e-09 37.2 0.2 9.3 9 0 0 9 9 9 7 Zinc-finger double domain zf-C2H2 PF00096.26 EMC79271.1 - 4.2e-37 124.5 53.2 5.1e-06 26.7 0.5 8.8 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC79271.1 - 1.5e-31 106.4 51.8 0.00075 20.1 2.1 9.0 8 0 0 8 8 8 8 C2H2-type zinc finger BTB PF00651.31 EMC79271.1 - 6.9e-24 84.2 0.2 1.6e-23 83.1 0.2 1.6 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_6 PF13912.6 EMC79271.1 - 2.4e-12 46.5 45.2 0.022 14.8 0.2 8.6 8 1 0 8 8 8 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC79271.1 - 7.9e-11 42.0 33.0 0.0031 17.8 0.2 8.4 9 0 0 9 9 8 5 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 EMC79271.1 - 3.9e-07 29.7 36.4 0.08 12.7 0.5 8.6 8 0 0 8 8 8 3 C2H2-type zinc-finger domain zf-met PF12874.7 EMC79271.1 - 8.4e-07 29.2 52.6 0.0026 18.1 0.5 9.1 9 0 0 9 9 9 4 Zinc-finger of C2H2 type zf-Di19 PF05605.12 EMC79271.1 - 4.4e-05 23.7 31.5 0.051 13.9 0.5 5.5 3 1 1 5 5 5 3 Drought induced 19 protein (Di19), zinc-binding zf-MYST PF17772.1 EMC79271.1 - 0.00051 19.6 20.4 6.1 6.5 0.1 8.2 8 1 1 9 9 9 1 MYST family zinc finger domain zf-C2H2_11 PF16622.5 EMC79271.1 - 0.0013 18.5 36.8 0.0016 18.2 0.4 8.3 8 0 0 8 8 8 1 zinc-finger C2H2-type zf_UBZ PF18439.1 EMC79271.1 - 0.0075 15.8 26.3 0.38 10.4 0.1 7.8 8 0 0 8 8 8 2 Ubiquitin-Binding Zinc Finger zf-C2H2_8 PF15909.5 EMC79271.1 - 0.012 15.9 23.0 0.068 13.5 6.2 4.8 1 1 3 4 4 4 0 C2H2-type zinc ribbon DUF3268 PF11672.8 EMC79271.1 - 0.023 15.0 20.5 0.4 11.0 0.6 4.4 3 1 1 4 4 4 0 zinc-finger-containing domain DUF3342 PF11822.8 EMC79271.1 - 0.023 14.9 0.2 0.13 12.5 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) zf_C2H2_13 PF18508.1 EMC79271.1 - 0.029 13.9 8.6 4.2 7.0 0.0 5.1 5 0 0 5 5 5 0 Zinc finger domain zf-BED PF02892.15 EMC79271.1 - 0.1 12.7 0.2 0.1 12.7 0.2 7.1 3 2 4 7 7 7 0 BED zinc finger Zn_ribbon_SprT PF17283.2 EMC79271.1 - 0.11 12.5 22.5 0.22 11.5 0.3 5.1 4 1 1 5 5 5 0 SprT-like zinc ribbon domain ADK_lid PF05191.14 EMC79271.1 - 0.13 12.3 31.0 2.2 8.3 0.8 6.5 4 2 3 7 7 6 0 Adenylate kinase, active site lid zf_C2H2_ZHX PF18387.1 EMC79271.1 - 0.2 11.3 0.1 0.2 11.3 0.1 6.8 4 1 4 8 8 8 0 Zinc-fingers and homeoboxes C2H2 finger domain zinc_ribbon_15 PF17032.5 EMC79271.1 - 0.25 12.1 32.8 0.69 10.7 2.2 5.5 1 1 3 5 5 5 0 zinc-ribbon family Vps36-NZF-N PF16988.5 EMC79271.1 - 0.43 10.0 15.8 6 6.4 0.4 5.0 3 1 2 5 5 5 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain GAGA PF09237.11 EMC79271.1 - 0.58 10.0 10.6 27 4.6 0.1 5.2 2 2 3 6 6 6 0 GAGA factor zf-C2H2_9 PF16293.5 EMC79271.1 - 1.3 8.9 9.2 25 4.8 0.0 5.7 6 0 0 6 6 6 0 C2H2 type zinc-finger (1 copy) zf-C2H2_3rep PF18868.1 EMC79271.1 - 3.3 8.4 29.8 3.1 8.5 0.8 6.1 1 1 2 5 5 5 0 Zinc finger C2H2-type, 3 repeats XPA_N PF01286.18 EMC79271.1 - 5.1 7.2 26.6 6.6 6.9 0.0 7.3 8 0 0 8 8 7 0 XPA protein N-terminal C1_4 PF07975.12 EMC79271.1 - 8.9 6.6 30.2 2.2 8.6 6.4 5.7 1 1 3 6 6 6 0 TFIIH C1-like domain zf-C2H2 PF00096.26 EMC79273.1 - 1e-49 164.2 78.0 5.3e-07 29.8 1.4 10.6 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC79273.1 - 1.8e-33 113.4 70.4 2.9e-08 33.8 1.2 11.9 12 0 0 12 12 11 6 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC79273.1 - 7.7e-33 110.3 73.0 0.00084 20.0 0.6 10.7 10 0 0 10 10 10 10 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC79273.1 - 1.6e-13 50.3 64.4 9e-05 22.4 0.2 10.1 10 0 0 10 10 10 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC79273.1 - 3.2e-11 43.2 56.7 0.0028 17.9 0.8 10.9 11 0 0 11 11 11 6 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 EMC79273.1 - 2.1e-06 27.4 61.8 4.4e-05 23.1 2.4 9.1 9 1 0 9 9 8 5 C2H2-type zinc-finger domain zf-BED PF02892.15 EMC79273.1 - 0.00065 19.7 0.5 0.00065 19.7 0.5 7.7 3 3 5 8 8 8 3 BED zinc finger zf-C2H2_8 PF15909.5 EMC79273.1 - 0.00091 19.5 39.8 0.16 12.2 8.2 5.8 2 1 3 5 5 5 3 C2H2-type zinc ribbon GAGA PF09237.11 EMC79273.1 - 0.0076 16.0 19.2 2.5 8.0 0.2 5.7 3 1 2 5 5 5 3 GAGA factor Zn-ribbon_8 PF09723.10 EMC79273.1 - 0.0082 16.2 1.6 0.0082 16.2 1.6 8.0 7 2 1 8 8 8 2 Zinc ribbon domain zf-C2H2_11 PF16622.5 EMC79273.1 - 0.02 14.7 57.4 0.051 13.3 0.8 8.5 10 0 0 10 10 9 0 zinc-finger C2H2-type zf-met PF12874.7 EMC79273.1 - 0.04 14.3 48.2 0.37 11.2 0.2 9.6 9 0 0 9 9 9 0 Zinc-finger of C2H2 type PyrI_C PF02748.15 EMC79273.1 - 0.21 11.5 27.9 0.35 10.8 0.0 6.9 6 1 1 7 7 7 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zinc_ribbon_15 PF17032.5 EMC79273.1 - 3.2 8.5 45.0 0.24 12.2 0.6 6.7 2 2 6 8 8 8 0 zinc-ribbon family BolA PF01722.18 EMC79273.1 - 9 6.7 13.4 17 5.8 0.1 5.8 5 3 1 6 6 4 0 BolA-like protein DUF948 PF06103.11 EMC79274.1 - 0.081 13.2 3.5 0.87 9.9 1.8 2.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF4525 PF15027.6 EMC79274.1 - 0.13 12.0 3.5 0.13 11.9 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4525) PI_PP_I PF18363.1 EMC79274.1 - 0.67 10.2 10.2 0.077 13.2 4.2 2.5 2 1 0 2 2 2 0 Phosphoinositide phosphatase insertion domain FlaC_arch PF05377.11 EMC79274.1 - 6 7.3 14.6 0.84 10.1 2.2 4.3 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) LRR_4 PF12799.7 EMC79275.1 - 2.6e-06 27.7 8.2 0.0014 19.0 0.2 3.9 2 1 3 5 5 5 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC79275.1 - 2.8e-06 26.9 0.7 4.4e-06 26.3 0.7 1.4 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 EMC79275.1 - 0.00078 19.2 7.1 0.12 12.1 0.5 3.6 1 1 2 3 3 3 3 Leucine rich repeat Serpin PF00079.20 EMC79276.1 - 6.5e-114 381.1 2.9 7.4e-114 380.9 2.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF1280 PF06918.14 EMC79276.1 - 0.049 13.2 0.5 0.08 12.5 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1280) DUF1241 PF06840.11 EMC79277.1 - 2.1e-63 212.4 3.2 2.9e-63 212.0 3.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) FH2 PF02181.23 EMC79277.1 - 0.00072 18.8 2.0 0.00072 18.8 2.0 1.5 1 1 0 1 1 1 1 Formin Homology 2 Domain CENP-L PF13092.6 EMC79277.1 - 0.0094 16.2 0.1 0.011 15.9 0.1 1.3 1 0 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 CREPT PF16566.5 EMC79277.1 - 0.018 15.2 0.8 0.032 14.4 0.8 1.5 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Med11 PF10280.9 EMC79277.1 - 0.028 14.9 1.1 0.077 13.5 0.4 2.0 1 1 2 3 3 3 0 Mediator complex protein SabA_adhesion PF18304.1 EMC79277.1 - 0.049 12.9 0.6 0.069 12.4 0.6 1.2 1 0 0 1 1 1 0 SabA N-terminal extracellular adhesion domain DUF4208 PF13907.6 EMC79277.1 - 0.06 13.8 1.1 20 5.7 0.0 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4208) DUF5344 PF17279.2 EMC79277.1 - 0.069 13.7 1.5 0.24 12.0 0.6 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5344) GCN5L1 PF06320.13 EMC79277.1 - 0.073 13.2 1.8 0.59 10.3 0.9 2.2 1 1 1 2 2 2 0 GCN5-like protein 1 (GCN5L1) SesA PF17107.5 EMC79277.1 - 0.076 13.2 2.3 0.1 12.8 0.9 2.0 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Sec23_trunk PF04811.15 EMC79277.1 - 0.086 12.4 1.2 2.4 7.7 1.3 2.6 1 1 0 1 1 1 0 Sec23/Sec24 trunk domain Syntaxin_2 PF14523.6 EMC79277.1 - 0.12 12.8 5.7 0.4 11.1 5.7 1.9 1 1 0 1 1 1 0 Syntaxin-like protein TFIIF_beta PF02270.15 EMC79277.1 - 0.14 12.3 1.0 0.44 10.7 0.3 2.2 2 0 0 2 2 2 0 TFIIF, beta subunit HTH domain NAAA-beta PF15508.6 EMC79277.1 - 0.2 12.0 0.7 2.8 8.3 0.1 2.7 3 0 0 3 3 2 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase KLRAQ PF10205.9 EMC79278.1 - 0.00028 21.1 4.2 0.00032 20.9 4.2 1.1 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein CENP-Q PF13094.6 EMC79278.1 - 0.00073 19.8 6.4 0.0008 19.6 6.4 1.1 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit FapA PF03961.13 EMC79278.1 - 0.0096 14.6 1.5 0.0093 14.6 1.5 1.0 1 0 0 1 1 1 1 Flagellar Assembly Protein A ZapB PF06005.12 EMC79278.1 - 0.013 15.9 11.2 0.021 15.3 11.2 1.2 1 0 0 1 1 1 0 Cell division protein ZapB DUF4482 PF14818.6 EMC79278.1 - 0.018 15.9 7.8 0.024 15.5 7.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4482) Ax_dynein_light PF10211.9 EMC79278.1 - 0.019 14.9 5.2 0.022 14.7 5.2 1.1 1 0 0 1 1 1 0 Axonemal dynein light chain Spc24 PF08286.11 EMC79278.1 - 0.04 14.2 2.9 0.043 14.0 2.9 1.2 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 DUF3027 PF11228.8 EMC79278.1 - 0.052 13.6 0.4 0.056 13.5 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3027) LMBR1 PF04791.16 EMC79278.1 - 0.061 12.2 1.0 0.055 12.4 1.0 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Herpes_UL6 PF01763.16 EMC79278.1 - 0.062 11.8 2.5 0.062 11.8 2.5 1.0 1 0 0 1 1 1 0 Herpesvirus UL6 like EMC3_TMCO1 PF01956.16 EMC79278.1 - 2.5 7.8 4.3 2.9 7.6 4.3 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like zf-C2H2 PF00096.26 EMC79281.1 - 7.1e-19 67.1 61.2 0.0026 18.1 2.0 8.7 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC79281.1 - 2.7e-17 61.9 58.9 0.0053 17.5 2.4 9.0 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC79281.1 - 1.2e-10 41.1 43.4 0.0037 17.2 3.1 7.3 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC79281.1 - 0.00027 21.1 27.6 0.24 11.7 0.7 6.9 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 EMC79281.1 - 0.0092 16.4 0.4 0.0092 16.4 0.4 6.9 7 1 0 7 7 6 2 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_2 PF13465.6 EMC79281.1 - 0.011 16.1 1.7 0.011 16.1 1.7 10.0 11 0 0 11 11 11 0 Zinc-finger double domain zf-MYST PF17772.1 EMC79281.1 - 0.53 9.9 14.8 2.4 7.8 0.2 5.3 5 0 0 5 5 5 0 MYST family zinc finger domain zf-CHCC PF10276.9 EMC79281.1 - 1.2 9.2 9.1 7.6 6.7 0.0 3.9 4 0 0 4 4 4 0 Zinc-finger domain zf-C2H2_11 PF16622.5 EMC79281.1 - 2.1 8.2 41.2 0.018 14.8 1.0 7.2 8 0 0 8 8 8 0 zinc-finger C2H2-type PyrI_C PF02748.15 EMC79281.1 - 2.4 8.1 23.4 0.59 10.1 0.2 6.7 6 1 1 7 7 7 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain PhnA_Zn_Ribbon PF08274.12 EMC79281.1 - 4.3 7.4 6.2 23 5.0 0.6 3.4 3 0 0 3 3 3 0 PhnA Zinc-Ribbon Podoplanin PF05808.11 EMC79282.1 - 1e-26 94.0 3.0 2.7e-26 92.6 1.8 1.8 1 1 1 2 2 2 2 Podoplanin Marek_A PF02124.15 EMC79282.1 - 0.15 11.9 0.0 0.18 11.6 0.0 1.1 1 0 0 1 1 1 0 Marek's disease glycoprotein A CYYR1 PF10873.8 EMC79282.1 - 2.4 8.6 4.4 4 7.9 4.4 1.3 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 LRR_8 PF13855.6 EMC79283.1 - 3.1e-34 116.5 21.5 7.3e-14 51.3 4.9 3.1 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EMC79283.1 - 4.5e-15 55.5 16.7 3.4e-05 24.1 0.8 4.7 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC79283.1 - 1.8e-10 40.9 1.9 3.3e-10 40.0 0.1 2.1 1 1 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EMC79283.1 - 2.1e-07 30.5 9.8 0.68 10.7 0.0 6.5 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_9 PF14580.6 EMC79283.1 - 3.2e-06 26.8 3.7 8.4e-05 22.1 1.5 2.1 1 1 1 2 2 2 2 Leucine-rich repeat DUF3557 PF12078.8 EMC79283.1 - 0.0027 17.6 0.1 0.0078 16.2 0.1 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF3557) LRR_3 PF07725.12 EMC79283.1 - 0.15 12.0 5.4 4.1 7.4 0.0 3.7 3 0 0 3 3 3 0 Leucine Rich Repeat LRRNT PF01462.18 EMC79283.1 - 0.22 11.2 3.8 0.88 9.3 3.8 2.1 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 EMC79283.1 - 0.28 11.3 0.2 0.28 11.3 0.2 5.4 6 0 0 6 6 6 0 Leucine Rich repeat Abhydrolase_3 PF07859.13 EMC79284.1 - 5.6e-59 199.5 0.1 1e-45 156.2 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 EMC79284.1 - 8.2e-10 38.2 0.3 4e-09 35.9 0.3 1.8 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 EMC79284.1 - 0.00021 20.3 0.0 0.00031 19.7 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 EMC79284.1 - 0.039 13.4 0.0 0.067 12.7 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EMC79285.1 - 1.1e-50 172.5 0.0 1.3e-38 133.0 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 EMC79285.1 - 0.00054 19.0 0.0 0.0017 17.3 0.0 1.7 1 1 0 1 1 1 1 Carboxylesterase family EIF_2_alpha PF07541.12 EMC79285.1 - 0.13 12.3 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit Abhydrolase_3 PF07859.13 EMC79286.1 - 2.1e-48 165.0 0.0 9.9e-37 126.8 0.0 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 EMC79286.1 - 6.8e-06 25.2 0.0 2.7e-05 23.2 0.0 1.7 1 1 0 1 1 1 1 Carboxylesterase family AXE1 PF05448.12 EMC79286.1 - 0.004 15.9 0.0 0.006 15.3 0.0 1.2 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.21 EMC79286.1 - 0.0043 16.5 0.0 0.0073 15.8 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family TNFR_c6 PF00020.18 EMC79288.1 - 2e-19 69.7 51.5 4.5e-06 27.0 8.5 4.7 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region DUF1180 PF06679.12 EMC79288.1 - 0.022 15.2 2.4 0.039 14.4 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Fzo_mitofusin PF04799.13 EMC79290.1 - 4.9e-76 253.8 12.1 5.8e-75 250.3 3.9 2.7 2 0 0 2 2 2 2 fzo-like conserved region Dynamin_N PF00350.23 EMC79290.1 - 2.7e-23 82.9 0.8 1.3e-22 80.7 0.0 2.6 3 0 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 EMC79290.1 - 6.6e-08 32.6 0.0 3.9e-07 30.1 0.0 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase Baculo_PEP_C PF04513.12 EMC79290.1 - 0.32 11.0 1.9 13 5.8 0.2 2.8 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Synaptobrevin PF00957.21 EMC79290.1 - 0.33 10.8 2.7 0.8 9.5 0.1 2.5 2 0 0 2 2 2 0 Synaptobrevin GTP_EFTU PF00009.27 EMC79290.1 - 0.45 10.0 2.4 3.6 7.1 0.0 2.7 1 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Streptin-Immun PF11083.8 EMC79290.1 - 0.54 10.7 5.3 0.13 12.7 0.4 2.4 2 0 0 2 2 2 0 Lantibiotic streptin immunity protein Apolipoprotein PF01442.18 EMC79290.1 - 2.3 8.0 12.2 3.7 7.4 5.5 2.6 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain 2OG-FeII_Oxy PF03171.20 EMC79291.1 - 2.2e-06 28.1 0.0 5.5e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Anp1 PF03452.14 EMC79291.1 - 2.6e-06 27.1 0.2 0.092 12.1 0.0 3.2 3 0 0 3 3 3 2 Anp1 2OG-FeII_Oxy_3 PF13640.6 EMC79291.1 - 4.2e-05 24.4 0.0 0.00014 22.7 0.0 1.9 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Trypsin PF00089.26 EMC79292.1 - 8.5e-69 231.7 3.7 9.8e-69 231.5 3.7 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EMC79292.1 - 1.5e-08 35.7 0.1 2.1e-08 35.2 0.1 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 EMC79292.1 - 2.1e-05 24.9 0.3 3.5e-05 24.2 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Guanylate_cyc PF00211.20 EMC79293.1 - 2.4e-69 232.6 0.0 2.9e-69 232.4 0.0 1.0 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 EMC79293.1 - 6e-05 22.6 1.0 8.5e-05 22.1 1.0 1.2 1 0 0 1 1 1 1 Heme NO binding associated Lactamase_B PF00753.27 EMC79293.1 - 0.1 12.6 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily ANP PF00212.18 EMC79295.1 - 3.2e-15 56.0 9.3 5.2e-15 55.3 9.3 1.4 1 0 0 1 1 1 1 Atrial natriuretic peptide ANP PF00212.18 EMC79296.1 - 3.4e-14 52.7 9.8 5.5e-14 52.1 9.8 1.3 1 0 0 1 1 1 1 Atrial natriuretic peptide ABC_tran_CTD PF16326.5 EMC79296.1 - 0.13 12.6 5.9 0.2 11.9 5.9 1.4 1 1 0 1 1 1 0 ABC transporter C-terminal domain Voltage_CLC PF00654.20 EMC79297.1 - 2.1e-97 326.6 24.3 6.6e-97 324.9 17.5 2.1 1 1 1 2 2 2 2 Voltage gated chloride channel CBS PF00571.28 EMC79297.1 - 8e-15 55.0 0.4 2.1e-08 34.5 0.0 3.0 3 0 0 3 3 3 2 CBS domain AGTRAP PF06396.11 EMC79298.1 - 1.3e-67 226.3 0.1 1.4e-67 226.1 0.1 1.0 1 0 0 1 1 1 1 Angiotensin II, type I receptor-associated protein (AGTRAP) Draxin PF15550.6 EMC79299.1 - 8e-139 463.0 11.3 8.9e-139 462.8 11.3 1.0 1 0 0 1 1 1 1 Draxin Dickkopf_N PF04706.12 EMC79299.1 - 3.4 8.2 14.2 7.4 7.1 14.2 1.6 1 0 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region HORMA PF02301.18 EMC79300.1 - 1.5e-09 37.8 0.1 2.7e-09 36.9 0.1 1.3 1 1 0 1 1 1 1 HORMA domain FBA PF04300.13 EMC79301.1 - 4.9e-74 247.9 0.3 6.4e-74 247.5 0.3 1.1 1 0 0 1 1 1 1 F-box associated region F-box-like PF12937.7 EMC79301.1 - 2.2e-12 46.6 5.7 5.9e-12 45.3 5.7 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMC79301.1 - 2.4e-08 33.6 4.8 4.9e-08 32.7 4.8 1.6 1 0 0 1 1 1 1 F-box domain RS4NT PF08071.12 EMC79301.1 - 0.014 15.5 0.2 0.029 14.5 0.2 1.5 1 0 0 1 1 1 0 RS4NT (NUC023) domain FBA PF04300.13 EMC79302.1 - 3.2e-80 268.0 0.2 3.9e-80 267.7 0.2 1.1 1 0 0 1 1 1 1 F-box associated region F-box PF00646.33 EMC79302.1 - 9.5e-10 38.1 0.9 1.8e-09 37.3 0.9 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EMC79302.1 - 1.3e-06 28.2 1.8 3.5e-06 26.8 1.8 1.7 1 0 0 1 1 1 1 F-box-like UbiA PF01040.18 EMC79303.1 - 1.1e-40 139.5 12.3 1.4e-40 139.2 12.3 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF1134 PF06577.12 EMC79303.1 - 0.11 12.2 0.2 0.16 11.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1134) Fibrinogen_C PF00147.18 EMC79304.1 - 3.2e-71 239.7 8.3 4.2e-71 239.3 8.3 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF4460 PF14687.6 EMC79304.1 - 0.041 13.9 0.0 0.086 12.9 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4460) DHR10 PF18595.1 EMC79304.1 - 0.95 9.5 5.4 1.5 8.9 5.4 1.3 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain DNA_pol_A_exo1 PF01612.20 EMC79305.1 - 5.5e-49 166.2 2.1 1e-48 165.4 2.1 1.5 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 EMC79305.1 - 6.5e-24 84.4 1.3 5.8e-23 81.4 0.0 3.2 3 2 0 3 3 3 1 PMC2NT (NUC016) domain HRDC PF00570.23 EMC79305.1 - 7.2e-14 51.5 0.0 1.8e-13 50.2 0.0 1.8 1 0 0 1 1 1 1 HRDC domain SPATIAL PF15256.6 EMC79305.1 - 0.26 11.6 8.0 0.49 10.7 7.0 2.0 2 0 0 2 2 2 0 SPATIAL Spermine_synth PF01564.17 EMC79306.1 - 6.8e-65 218.0 0.0 9.9e-65 217.5 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Methyltransf_31 PF13847.6 EMC79306.1 - 1e-05 25.3 0.0 1.2e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC79306.1 - 0.00019 22.1 0.0 0.0008 20.1 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 EMC79306.1 - 0.057 13.3 0.0 0.13 12.2 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 EMC79306.1 - 0.085 13.6 0.0 0.34 11.7 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_30 PF05430.11 EMC79306.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase Somatostatin PF03002.15 EMC79307.1 - 9.4e-12 44.6 7.1 1.5e-11 44.0 7.1 1.3 1 0 0 1 1 1 1 Somatostatin/Cortistatin family CUB PF00431.20 EMC79308.1 - 1e-18 67.6 0.1 1.6e-18 67.1 0.1 1.2 1 0 0 1 1 1 1 CUB domain FXa_inhibition PF14670.6 EMC79308.1 - 3.6e-08 33.5 9.8 8.2e-08 32.4 9.8 1.6 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 EMC79308.1 - 1.7e-07 31.3 7.9 3.5e-07 30.3 7.9 1.5 1 0 0 1 1 1 1 Calcium-binding EGF domain cEGF PF12662.7 EMC79308.1 - 0.00034 20.5 4.0 0.00034 20.5 4.0 2.7 3 0 0 3 3 3 1 Complement Clr-like EGF-like EGF PF00008.27 EMC79308.1 - 0.00044 20.5 8.6 0.0012 19.1 8.6 1.8 1 0 0 1 1 1 1 EGF-like domain CUB_2 PF02408.20 EMC79308.1 - 0.013 15.2 0.2 0.025 14.3 0.1 1.5 2 0 0 2 2 2 0 CUB-like domain TDP43_N PF18694.1 EMC79309.1 - 1.8e-33 114.2 0.0 3e-33 113.5 0.0 1.4 1 0 0 1 1 1 1 Transactive response DNA-binding protein N-terminal domain RRM_1 PF00076.22 EMC79309.1 - 1.8e-27 94.9 0.2 1.8e-15 56.5 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMC79309.1 - 5.4e-08 32.8 0.8 0.0068 16.5 0.0 3.2 3 1 0 3 3 3 2 RNA recognition motif RL PF17797.1 EMC79309.1 - 0.00025 20.9 0.0 0.13 12.2 0.0 2.3 2 0 0 2 2 2 2 RL domain RRM_3 PF08777.11 EMC79309.1 - 0.00088 19.3 0.0 0.11 12.6 0.0 2.4 2 0 0 2 2 2 1 RNA binding motif Nup35_RRM_2 PF14605.6 EMC79309.1 - 0.019 15.0 0.1 0.62 10.1 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 EMC79309.1 - 0.092 12.3 0.1 1.7 8.3 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RXT2_N PF08595.11 EMC79310.1 - 0.15 12.1 7.7 0.64 10.0 7.7 2.2 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF240 PF03086.14 EMC79310.1 - 0.21 11.5 0.3 5.7 6.9 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF240) Pex14_N PF04695.13 EMC79311.1 - 3.8e-21 76.4 1.9 3.8e-21 76.4 1.9 4.0 2 2 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region HemX PF04375.14 EMC79311.1 - 0.00025 20.4 4.4 0.00025 20.4 4.4 1.5 2 0 0 2 2 2 1 HemX, putative uroporphyrinogen-III C-methyltransferase DUF948 PF06103.11 EMC79311.1 - 0.0047 17.2 0.4 0.01 16.1 0.4 1.5 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF948) CC2-LZ PF16516.5 EMC79311.1 - 0.035 14.5 1.9 0.035 14.5 1.9 2.3 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Calici_PP_N PF08405.11 EMC79311.1 - 0.052 12.4 0.1 0.074 11.9 0.1 1.1 1 0 0 1 1 1 0 Viral polyprotein N-terminal Fib_alpha PF08702.10 EMC79311.1 - 0.12 12.6 4.6 0.28 11.4 4.6 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family GLE1 PF07817.13 EMC79311.1 - 0.2 10.9 3.3 0.3 10.3 3.3 1.2 1 0 0 1 1 1 0 GLE1-like protein Phage_Gp23 PF10669.9 EMC79311.1 - 1.1 9.6 13.2 1.3 9.4 4.5 2.3 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) TolA_bind_tri PF16331.5 EMC79311.1 - 1.6 8.8 12.0 1.9 8.6 7.4 2.7 2 1 1 3 3 3 0 TolA binding protein trimerisation SPG4 PF17325.2 EMC79311.1 - 7.9 7.6 7.9 17 6.5 3.0 2.3 2 0 0 2 2 2 0 Stationary phase protein 4 DFF-C PF09033.10 EMC79312.1 - 3e-62 209.4 19.1 7.1e-62 208.2 11.9 2.1 2 0 0 2 2 2 2 DNA Fragmentation factor 45kDa, C terminal domain CIDE-N PF02017.15 EMC79312.1 - 2.7e-17 62.5 0.0 3.1e-15 56.0 0.0 2.7 2 0 0 2 2 2 1 CIDE-N domain DUF4564 PF15169.6 EMC79312.1 - 0.07 12.8 0.4 0.13 12.0 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4564) Macoilin PF09726.9 EMC79312.1 - 3 6.3 17.5 0.49 8.9 9.5 2.1 1 1 1 2 2 2 0 Macoilin family CENP-S PF15630.6 EMC79313.1 - 4.1e-08 33.5 0.1 8.4e-08 32.5 0.1 1.5 1 0 0 1 1 1 1 CENP-S protein COMMD1_N PF17221.3 EMC79313.1 - 0.0086 16.4 0.3 0.01 16.1 0.3 1.2 1 0 0 1 1 1 1 COMMD1 N-terminal domain CENP-T_C PF15511.6 EMC79313.1 - 0.023 14.8 0.4 0.031 14.4 0.4 1.3 1 1 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EMC79313.1 - 0.089 13.2 0.3 0.089 13.2 0.3 2.1 1 1 1 2 2 2 0 Core histone H2A/H2B/H3/H4 6PGD PF00393.19 EMC79314.1 - 2.5e-127 424.2 0.0 2.9e-127 424.0 0.0 1.0 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain Kinesin PF00225.23 EMC79315.1 - 2.5e-116 388.2 0.4 4.1e-116 387.6 0.4 1.3 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.5 EMC79315.1 - 5.9e-77 257.9 14.4 4.5e-76 255.0 3.8 3.6 3 1 0 3 3 3 1 Kinesin-associated DUF3694 PF12473.8 EMC79315.1 - 4.7e-39 134.5 0.0 1.4e-38 132.9 0.0 1.9 1 0 0 1 1 1 1 Kinesin protein Microtub_bd PF16796.5 EMC79315.1 - 2.3e-25 89.2 0.1 7e-24 84.5 0.1 2.8 2 0 0 2 2 2 1 Microtubule binding KIF1B PF12423.8 EMC79315.1 - 1.5e-14 54.1 14.1 6e-12 45.8 0.2 3.7 3 0 0 3 3 3 2 Kinesin protein 1B PH PF00169.29 EMC79315.1 - 8.1e-13 48.8 0.1 5.5e-11 42.9 0.0 4.0 4 0 0 4 4 4 1 PH domain FHA PF00498.26 EMC79315.1 - 5.3e-08 33.1 0.3 2.7e-07 30.8 0.1 2.4 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 EMC79315.1 - 0.0019 18.5 0.0 0.0053 17.0 0.0 1.8 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Ufd2P_core PF10408.9 EMC79316.1 - 6.5e-199 662.6 10.3 8.4e-199 662.2 10.3 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 EMC79316.1 - 1.8e-07 31.2 0.6 5.4e-07 29.7 0.2 2.2 2 0 0 2 2 2 1 U-box domain CTP_transf_like PF01467.26 EMC79317.1 - 2.8e-22 79.5 0.1 6.7e-22 78.2 0.0 1.5 1 1 0 1 1 1 1 Cytidylyltransferase-like Lipocalin PF00061.23 EMC79317.1 - 1.6e-12 47.9 0.7 2.5e-12 47.2 0.7 1.3 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family ICAT PF06384.11 EMC79318.1 - 1.6e-33 114.7 0.1 1.6e-33 114.7 0.1 2.3 2 1 0 2 2 2 1 Beta-catenin-interacting protein ICAT CAMP_factor PF07373.11 EMC79318.1 - 0.00035 20.2 1.1 0.00052 19.7 1.1 1.3 1 0 0 1 1 1 1 CAMP factor (Cfa) GvpG PF05120.12 EMC79318.1 - 0.0021 18.0 10.4 0.01 15.8 0.2 2.4 2 0 0 2 2 2 1 Gas vesicle protein G Serine_rich PF08824.10 EMC79318.1 - 0.0041 17.1 1.7 0.0062 16.6 1.7 1.3 1 0 0 1 1 1 1 Serine rich protein interaction domain DMAP_binding PF06464.11 EMC79318.1 - 0.027 15.3 0.3 0.027 15.3 0.3 2.3 2 0 0 2 2 2 0 DMAP1-binding Domain Spc7 PF08317.11 EMC79318.1 - 0.032 13.1 7.6 0.041 12.8 7.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Importin_rep_6 PF18829.1 EMC79318.1 - 0.047 13.8 0.6 0.087 13.0 0.6 1.4 1 0 0 1 1 1 0 Importin repeat 6 Robl_LC7 PF03259.17 EMC79318.1 - 0.055 13.2 0.2 0.37 10.6 0.0 2.2 2 0 0 2 2 2 0 Roadblock/LC7 domain DUF3313 PF11769.8 EMC79318.1 - 0.064 13.1 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3313) FlxA PF14282.6 EMC79318.1 - 0.07 13.1 11.1 0.13 12.3 8.9 2.2 1 1 1 2 2 2 0 FlxA-like protein Imm40 PF15569.6 EMC79318.1 - 0.087 12.9 0.1 12 6.1 0.1 2.4 2 0 0 2 2 2 0 Immunity protein 40 TetR_C_7 PF14246.6 EMC79318.1 - 0.09 12.8 0.5 0.16 12.0 0.1 1.8 2 0 0 2 2 1 0 AefR-like transcriptional repressor, C-terminal domain CK2S PF15011.6 EMC79318.1 - 0.14 12.1 9.2 0.66 9.9 0.0 2.6 2 1 1 3 3 3 0 Casein Kinase 2 substrate DUF4254 PF14063.6 EMC79318.1 - 0.36 10.6 5.7 0.47 10.2 1.5 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4254) Cauli_AT PF03233.13 EMC79318.1 - 0.36 10.7 3.1 0.71 9.8 3.1 1.4 1 0 0 1 1 1 0 Aphid transmission protein Allexi_40kDa PF05549.11 EMC79318.1 - 0.67 9.4 3.8 0.96 8.9 3.1 1.6 1 1 0 1 1 1 0 Allexivirus 40kDa protein Laminin_II PF06009.12 EMC79318.1 - 0.72 9.9 7.4 2.4 8.2 1.3 2.8 2 1 1 3 3 3 0 Laminin Domain II WXG100 PF06013.12 EMC79318.1 - 0.8 10.0 4.6 0.5 10.6 0.9 2.5 3 1 0 3 3 2 0 Proteins of 100 residues with WXG Baculo_p24 PF05073.12 EMC79318.1 - 0.85 9.4 4.0 13 5.6 2.5 2.0 1 1 1 2 2 2 0 Baculovirus P24 capsid protein DUF2408 PF10303.9 EMC79318.1 - 0.91 10.1 7.8 1.9 9.1 7.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) NPV_P10 PF05531.12 EMC79318.1 - 1.2 9.6 5.3 1.4 9.4 3.4 2.2 2 1 0 2 2 1 0 Nucleopolyhedrovirus P10 protein XhlA PF10779.9 EMC79318.1 - 3.3 8.0 7.3 22 5.3 7.3 2.3 1 1 0 1 1 1 0 Haemolysin XhlA DUF1664 PF07889.12 EMC79318.1 - 4.2 7.4 7.2 5.9 7.0 4.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) YojJ PF10372.9 EMC79318.1 - 6 7.0 8.9 6 7.0 1.3 2.9 2 1 1 3 3 2 0 Bacterial membrane-spanning protein N-terminus FapA PF03961.13 EMC79318.1 - 8.8 4.8 7.8 12 4.3 7.8 1.4 1 1 0 1 1 1 0 Flagellar Assembly Protein A ICAT PF06384.11 EMC79319.1 - 4.3e-23 81.4 0.1 4.8e-23 81.2 0.1 1.0 1 0 0 1 1 1 1 Beta-catenin-interacting protein ICAT Cadherin PF00028.17 EMC79320.1 - 2.4e-16 59.9 0.0 3.7e-08 33.7 0.0 2.8 2 0 0 2 2 2 2 Cadherin domain Laminin_G_3 PF13385.6 EMC79320.1 - 1.1e-05 25.7 0.0 2.2e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 EMC79320.1 - 0.0015 19.2 0.0 0.0067 17.0 0.0 2.2 2 0 0 2 2 2 1 Laminin G domain PI3_PI4_kinase PF00454.27 EMC79321.1 - 1.2e-59 202.2 0.1 3.6e-59 200.6 0.1 1.9 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EMC79321.1 - 4.5e-56 189.2 2.8 8.2e-56 188.3 2.8 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_rbd PF00794.18 EMC79321.1 - 3.2e-24 85.1 0.1 1.2e-23 83.3 0.0 2.1 2 0 0 2 2 2 1 PI3-kinase family, ras-binding domain PI3K_C2 PF00792.24 EMC79321.1 - 4.7e-23 81.6 0.0 1.1e-22 80.4 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 DUF4135 PF13575.6 EMC79321.1 - 0.01 15.2 0.0 0.017 14.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) PI3K_p85B PF02192.16 EMC79322.1 - 6.7e-33 112.3 0.0 8.4e-33 112.0 0.0 1.1 1 0 0 1 1 1 1 PI3-kinase family, p85-binding domain DUF2448 PF10476.9 EMC79323.1 - 4.1e-95 317.5 1.7 6.5e-95 316.8 1.7 1.3 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2448) Ima1_N PF09779.9 EMC79323.1 - 2.6e-33 115.8 13.7 6.7e-33 114.4 13.7 1.7 1 0 0 1 1 1 1 Ima1 N-terminal domain zf-RRPl_C4 PF17026.5 EMC79323.1 - 0.66 10.1 14.4 0.15 12.2 10.5 2.0 2 1 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type MARVEL PF01284.23 EMC79323.1 - 0.84 9.7 4.8 3.9 7.5 4.7 2.2 1 1 1 2 2 2 0 Membrane-associating domain Mito_carr PF00153.27 EMC79324.1 - 1.5e-61 204.3 0.9 3.5e-20 71.7 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein 7tm_2 PF00002.24 EMC79325.1 - 7.3e-12 45.1 11.5 9.9e-12 44.7 11.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.11 EMC79325.1 - 1.1e-07 31.3 12.4 3.7e-07 29.6 12.4 1.8 1 1 0 1 1 1 1 Slime mold cyclic AMP receptor Frizzled PF01534.17 EMC79325.1 - 7e-05 22.0 13.1 0.029 13.4 13.1 2.3 1 1 0 1 1 1 1 Frizzled/Smoothened family membrane region 7tm_1 PF00001.21 EMC79325.1 - 0.029 13.7 8.4 0.013 14.9 6.4 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Sugar_tr PF00083.24 EMC79326.1 - 1.1e-130 436.6 26.4 1.3e-130 436.4 26.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMC79326.1 - 1e-20 74.0 53.1 2.9e-18 65.9 26.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Carb_anhydrase PF00194.21 EMC79327.1 - 2.8e-87 292.5 0.1 3.6e-87 292.1 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Pentaxin PF00354.17 EMC79327.1 - 4.8e-36 124.3 0.0 7.2e-36 123.7 0.0 1.3 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.6 EMC79327.1 - 5.3e-10 39.6 0.5 9.6e-10 38.8 0.5 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Enolase_C PF00113.22 EMC79328.1 - 1.8e-159 529.7 0.0 2.4e-159 529.3 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EMC79328.1 - 1.4e-60 203.2 0.1 2.4e-60 202.5 0.1 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 EMC79328.1 - 1.6e-08 34.4 0.0 2.3e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 EMC79328.1 - 0.00012 21.4 0.3 0.00027 20.2 0.3 1.6 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus Noc2 PF03715.13 EMC79329.1 - 2.3e-122 408.0 8.0 2.3e-122 408.0 8.0 1.8 2 0 0 2 2 2 1 Noc2p family Kelch_1 PF01344.25 EMC79330.1 - 5.1e-79 259.7 16.0 3.7e-16 58.4 0.3 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EMC79330.1 - 1.4e-43 145.8 3.7 2.3e-09 37.2 0.0 6.5 1 1 5 6 6 6 6 Kelch motif BACK PF07707.15 EMC79330.1 - 8.7e-37 125.4 0.1 1.9e-36 124.3 0.1 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.31 EMC79330.1 - 1.2e-33 115.6 0.6 2.4e-33 114.7 0.2 1.7 2 0 0 2 2 2 1 BTB/POZ domain Kelch_4 PF13418.6 EMC79330.1 - 1e-27 95.8 1.2 2.6e-06 27.3 0.0 6.3 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 EMC79330.1 - 2.1e-26 91.6 16.2 7.6e-07 29.3 0.1 6.5 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.15 EMC79330.1 - 5.6e-25 86.3 2.3 0.00013 21.7 0.1 6.0 6 0 0 6 6 6 5 Kelch motif Kelch_5 PF13854.6 EMC79330.1 - 4.7e-09 36.0 5.5 0.1 12.6 0.0 5.5 5 0 0 5 5 5 3 Kelch motif BA14K PF07886.11 EMC79330.1 - 0.033 14.1 2.0 0.76 9.7 0.0 3.8 4 0 0 4 4 4 0 BA14K-like protein XPA_C PF05181.12 EMC79330.1 - 0.13 12.2 0.5 27 4.8 0.0 2.8 3 0 0 3 3 3 0 XPA protein C-terminus PQQ_3 PF13570.6 EMC79330.1 - 3 8.4 13.0 22 5.7 0.1 5.7 6 0 0 6 6 6 0 PQQ-like domain Hairy_orange PF07527.13 EMC79334.1 - 1.2e-19 70.2 0.4 2.1e-19 69.4 0.4 1.4 1 0 0 1 1 1 1 Hairy Orange HLH PF00010.26 EMC79334.1 - 1.1e-15 57.4 4.2 1.5e-15 56.8 3.4 1.7 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Cytadhesin_P30 PF07271.11 EMC79334.1 - 0.58 9.7 12.2 0.99 8.9 12.2 1.3 1 0 0 1 1 1 0 Cytadhesin P30/P32 Kazal_2 PF07648.15 EMC79335.1 - 1.7e-63 210.5 119.1 2.9e-11 43.3 4.8 10.7 10 1 1 11 11 11 8 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EMC79335.1 - 7.7e-52 173.1 112.4 2.6e-12 46.5 0.1 10.1 9 0 0 9 9 9 8 Kazal-type serine protease inhibitor domain NtA PF03146.15 EMC79335.1 - 2e-25 88.8 0.0 4.4e-25 87.7 0.0 1.6 1 0 0 1 1 1 1 Agrin NtA domain Laminin_G_1 PF00054.23 EMC79335.1 - 8e-21 74.6 0.0 1.3e-20 74.0 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_EGF PF00053.24 EMC79335.1 - 7.7e-19 67.6 32.3 1.1e-12 47.9 11.7 14.2 9 4 4 13 13 13 2 Laminin EGF domain SEA PF01390.20 EMC79335.1 - 8.9e-16 57.9 0.0 1.4e-15 57.2 0.0 1.3 1 0 0 1 1 1 1 SEA domain Laminin_G_2 PF02210.24 EMC79335.1 - 2.1e-12 47.7 0.0 3.5e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain EGF PF00008.27 EMC79335.1 - 3.8e-06 27.1 7.8 3.8e-06 27.1 7.8 11.9 11 1 0 11 11 11 1 EGF-like domain hEGF PF12661.7 EMC79335.1 - 0.0054 17.3 4.9 0.0054 17.3 4.9 13.7 13 1 0 13 13 13 2 Human growth factor-like EGF Y_phosphatase PF00102.27 EMC79336.1 - 1.7e-78 263.4 0.8 3e-78 262.6 0.3 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase SH2 PF00017.24 EMC79336.1 - 1.3e-52 175.8 0.0 3.6e-25 87.8 0.0 2.8 2 0 0 2 2 2 2 SH2 domain DSPc PF00782.20 EMC79336.1 - 3.5e-05 23.6 0.0 0.00015 21.6 0.0 2.2 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EMC79336.1 - 0.0027 17.8 1.2 0.01 16.0 0.0 2.6 3 0 0 3 3 3 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 EMC79336.1 - 0.0028 17.7 0.2 0.0066 16.5 0.0 1.8 2 0 0 2 2 2 1 Tyrosine phosphatase family Collagen_bind_2 PF12904.7 EMC79336.1 - 0.07 13.1 0.6 1 9.4 0.0 2.5 2 0 0 2 2 2 0 Putative collagen-binding domain of a collagenase Cbl_N3 PF02762.14 EMC79336.1 - 0.12 12.3 0.0 1.2 9.0 0.0 2.6 3 0 0 3 3 3 0 CBL proto-oncogene N-terminus, SH2-like domain Membrane_bind PF14564.6 EMC79336.1 - 0.13 12.7 0.2 0.78 10.2 0.1 2.3 3 0 0 3 3 3 0 Membrane binding UPF0254 PF06787.11 EMC79336.1 - 0.15 11.8 0.1 0.3 10.8 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0254) zf-RING_5 PF14634.6 EMC79337.1 - 2.9e-09 36.7 6.4 2.9e-09 36.7 6.4 2.0 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.6 EMC79337.1 - 4.3e-09 36.6 6.8 4.3e-09 36.6 6.8 2.1 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 EMC79337.1 - 3.5e-08 33.3 7.6 3.8e-08 33.2 5.1 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EMC79337.1 - 1.2e-06 28.3 4.1 1.2e-06 28.3 4.1 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC79337.1 - 3.4e-06 26.8 7.0 3.4e-06 26.8 7.0 2.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMC79337.1 - 3.3e-05 24.0 7.2 0.00018 21.6 7.2 2.4 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 EMC79337.1 - 0.00014 21.5 5.0 0.00033 20.3 5.0 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EMC79337.1 - 0.0032 17.3 10.8 0.0032 17.3 10.8 2.6 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) UBM PF14377.6 EMC79337.1 - 0.011 15.1 0.4 0.02 14.3 0.4 1.5 1 0 0 1 1 1 0 Ubiquitin binding region zf-RING_4 PF14570.6 EMC79337.1 - 0.024 14.5 5.7 0.024 14.5 5.7 2.0 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 EMC79337.1 - 0.18 12.1 6.4 1.3 9.4 6.4 2.4 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_10 PF16685.5 EMC79337.1 - 0.49 10.6 7.6 6 7.1 5.2 2.8 2 1 1 3 3 3 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 EMC79337.1 - 6.1 6.8 17.7 0.044 13.6 7.5 2.7 3 1 0 3 3 3 0 Prokaryotic RING finger family 4 DUF4501 PF14946.6 EMC79338.1 - 5.3e-89 297.0 4.7 6.2e-89 296.7 4.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4501) UPF0560 PF10577.9 EMC79339.1 - 0.021 13.4 0.3 0.03 12.9 0.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Syndecan PF01034.20 EMC79339.1 - 0.24 11.3 1.5 0.48 10.4 1.5 1.4 1 0 0 1 1 1 0 Syndecan domain TNFR_c6 PF00020.18 EMC79340.1 - 1.2e-18 67.3 36.3 5.8e-07 29.8 2.8 3.7 3 0 0 3 3 3 3 TNFR/NGFR cysteine-rich region TMEM154 PF15102.6 EMC79340.1 - 0.0017 18.3 0.0 0.021 14.7 0.1 2.2 2 0 0 2 2 2 1 TMEM154 protein family DUF4834 PF16118.5 EMC79340.1 - 0.23 12.5 1.3 0.23 12.4 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ephrin_rec_like PF07699.13 EMC79340.1 - 4 7.3 26.3 0.094 12.5 3.3 3.5 2 1 1 3 3 3 0 Putative ephrin-receptor like EF-hand_1 PF00036.32 EMC79341.1 - 2.8e-21 73.4 7.7 0.00045 19.6 0.0 6.4 6 0 0 6 6 6 5 EF hand EF-hand_7 PF13499.6 EMC79341.1 - 2.6e-15 56.6 17.5 1.5e-07 31.8 1.6 4.6 3 2 2 5 5 5 4 EF-hand domain pair EF-hand_6 PF13405.6 EMC79341.1 - 4.6e-14 51.1 1.6 0.059 13.3 0.0 5.7 6 0 0 6 6 6 4 EF-hand domain EF-hand_5 PF13202.6 EMC79341.1 - 6.2e-13 47.6 2.2 0.0015 17.9 0.0 5.2 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 EMC79341.1 - 5.1e-07 29.4 6.9 0.0094 15.8 0.0 5.0 4 2 1 5 5 5 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EMC79341.1 - 0.00058 20.2 16.8 0.16 12.3 1.7 3.5 2 1 1 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region Pex14_N PF04695.13 EMC79341.1 - 0.02 15.6 0.2 0.041 14.5 0.2 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DsrC PF04358.13 EMC79341.1 - 0.039 14.5 0.7 0.2 12.2 0.1 2.4 2 1 0 2 2 2 0 DsrC like protein C1q PF00386.21 EMC79342.1 - 2.2e-06 27.9 0.1 7e-06 26.3 0.0 1.9 2 1 0 2 2 2 1 C1q domain Collagen PF01391.18 EMC79342.1 - 0.0044 16.7 4.5 0.0069 16.1 4.5 1.2 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) TNF PF00229.18 EMC79342.1 - 0.14 12.1 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 TNF(Tumour Necrosis Factor) family UQ_con PF00179.26 EMC79343.1 - 1.2e-18 67.1 0.0 1.8e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme ASC PF00858.24 EMC79344.1 - 1.8e-107 360.1 13.3 2.2e-107 359.8 13.3 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel BAR_3 PF16746.5 EMC79345.1 - 5.5e-82 275.0 10.8 9.5e-82 274.3 10.8 1.3 1 0 0 1 1 1 1 BAR domain of APPL family ArfGap PF01412.18 EMC79345.1 - 5.9e-41 139.2 0.5 2.1e-40 137.5 0.5 2.0 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 EMC79345.1 - 3.1e-14 53.3 0.2 3.1e-14 53.3 0.2 2.0 2 0 0 2 2 1 1 PH domain Ank_2 PF12796.7 EMC79345.1 - 3e-06 27.7 0.3 0.00026 21.5 0.3 2.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC79345.1 - 1.7e-05 25.2 0.2 0.38 11.4 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) BAR PF03114.18 EMC79345.1 - 0.0021 17.7 7.1 0.0042 16.8 7.1 1.5 1 0 0 1 1 1 1 BAR domain PH_11 PF15413.6 EMC79345.1 - 0.012 16.0 5.0 0.096 13.1 2.5 2.8 2 1 0 2 2 1 0 Pleckstrin homology domain Ank PF00023.30 EMC79345.1 - 0.04 14.4 1.0 14 6.3 0.1 3.4 3 0 0 3 3 3 0 Ankyrin repeat Ank_5 PF13857.6 EMC79345.1 - 0.041 14.2 0.8 3.4 8.1 0.0 3.0 1 1 3 4 4 4 0 Ankyrin repeats (many copies) Exonuc_VII_L PF02601.15 EMC79345.1 - 0.053 13.1 1.4 0.1 12.1 1.4 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit PH_8 PF15409.6 EMC79345.1 - 0.12 12.7 0.1 0.39 11.0 0.1 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain Ank_3 PF13606.6 EMC79345.1 - 0.26 12.0 0.5 88 4.2 0.0 3.9 3 0 0 3 3 3 0 Ankyrin repeat PseudoU_synth_1 PF01416.20 EMC79346.1 - 7.2e-36 122.9 0.0 7.8e-29 100.3 0.0 2.1 2 0 0 2 2 2 2 tRNA pseudouridine synthase Peptidase_C31 PF05410.13 EMC79346.1 - 0.023 14.7 0.0 6.8 6.8 0.0 2.4 2 0 0 2 2 2 0 Porcine arterivirus-type cysteine proteinase alpha 7tm_1 PF00001.21 EMC79347.1 - 5.7e-44 150.4 27.2 7.4e-44 150.0 27.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PGG PF13962.6 EMC79347.1 - 0.0066 16.2 0.4 0.0066 16.2 0.4 2.9 2 1 1 3 3 3 1 Domain of unknown function 7tm_4 PF13853.6 EMC79347.1 - 0.6 9.8 26.1 1.7 8.3 26.1 1.7 1 1 0 1 1 1 0 Olfactory receptor Beta-Casp PF10996.8 EMC79348.1 - 9.1e-26 90.3 0.0 3.1e-25 88.6 0.0 2.0 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B_6 PF16661.5 EMC79348.1 - 5.6e-23 81.4 0.0 1.1e-22 80.4 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 EMC79348.1 - 2.1e-20 72.4 0.1 4.3e-20 71.4 0.1 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 EMC79348.1 - 7.5e-11 42.4 0.1 1.8e-08 34.6 0.0 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EMC79348.1 - 2.1e-09 37.2 0.6 1.9e-08 34.1 0.1 2.2 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EMC79348.1 - 0.00013 22.0 0.1 0.001 19.0 0.0 2.5 3 1 0 3 3 3 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 EMC79348.1 - 0.0016 17.7 0.1 0.0053 16.0 0.1 1.9 1 1 0 1 1 1 1 Putative beta-lactamase-like family GLTP PF08718.11 EMC79349.1 - 2.6e-32 112.2 0.0 3.2e-32 111.9 0.0 1.1 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) V-set PF07686.17 EMC79350.1 - 1.5e-27 95.9 0.5 5.6e-16 58.7 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.25 EMC79350.1 - 1.6e-09 37.8 2.0 0.0028 17.8 0.2 3.9 2 2 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 EMC79350.1 - 3.8e-08 33.8 1.9 0.0067 17.0 0.3 3.8 2 2 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC79350.1 - 7.5e-08 32.3 0.1 0.018 15.1 0.0 2.8 3 0 0 3 3 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC79350.1 - 0.0026 18.1 1.9 0.46 10.8 0.1 3.1 2 1 0 2 2 2 1 Immunoglobulin domain Stevor PF17410.2 EMC79350.1 - 0.0031 17.1 0.2 0.0049 16.5 0.2 1.3 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame Ig_6 PF18452.1 EMC79350.1 - 0.0036 16.8 0.0 2.3 7.9 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain FixQ PF05545.11 EMC79350.1 - 0.0047 16.9 1.2 0.0098 15.8 1.2 1.5 1 0 0 1 1 1 1 Cbb3-type cytochrome oxidase component FixQ Izumo-Ig PF16706.5 EMC79350.1 - 0.0062 16.6 0.0 4.4 7.4 0.0 2.7 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.8 EMC79350.1 - 0.037 14.2 0.1 5.6 7.2 0.0 2.8 2 1 0 2 2 2 0 Natural killer cell receptor 2B4 DUF4064 PF13273.6 EMC79350.1 - 0.061 13.6 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) TMEM154 PF15102.6 EMC79350.1 - 0.18 11.7 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family DUF347 PF03988.12 EMC79350.1 - 0.26 11.5 1.0 0.46 10.7 1.0 1.3 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) DUF1713 PF08213.11 EMC79351.1 - 3.1e-11 43.0 20.6 3.1e-11 43.0 20.6 2.2 2 0 0 2 2 2 1 Mitochondrial domain of unknown function (DUF1713) adh_short PF00106.25 EMC79352.1 - 1.6e-30 106.0 0.5 2.2e-30 105.6 0.5 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC79352.1 - 1.5e-24 86.9 0.1 1.9e-24 86.5 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC79352.1 - 1.9e-08 34.4 0.1 3.4e-08 33.6 0.0 1.4 1 1 0 1 1 1 1 KR domain ADH_zinc_N PF00107.26 EMC79352.1 - 0.0066 16.4 0.1 0.01 15.8 0.1 1.4 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Cyclin_N PF00134.23 EMC79353.1 - 1.9e-14 53.5 1.1 2.5e-08 33.7 0.1 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 EMC79353.1 - 8.4e-07 29.1 0.1 8.4e-07 29.1 0.1 2.1 3 0 0 3 3 3 1 Cyclin, C-terminal domain TFIIB PF00382.19 EMC79353.1 - 0.00031 20.7 0.5 0.28 11.3 0.1 2.7 2 0 0 2 2 2 2 Transcription factor TFIIB repeat Cyclin_C_2 PF16899.5 EMC79353.1 - 0.0026 18.1 0.0 0.0069 16.7 0.0 1.9 2 0 0 2 2 2 1 Cyclin C-terminal domain E2F_TDP PF02319.20 EMC79353.1 - 0.021 14.8 0.1 0.35 10.9 0.0 2.3 2 0 0 2 2 2 0 E2F/DP family winged-helix DNA-binding domain DUF936 PF06075.12 EMC79353.1 - 8.8 5.1 29.6 12 4.7 29.6 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) Ribosomal_L20 PF00453.18 EMC79354.1 - 6.1e-35 119.6 4.3 8.3e-35 119.1 4.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L20 DUF2852 PF11014.8 EMC79355.1 - 0.28 11.3 1.7 0.31 11.2 0.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2852) FtsX PF02687.21 EMC79355.1 - 1 9.9 11.5 0.87 10.1 9.5 1.7 1 1 1 2 2 2 0 FtsX-like permease family VWA PF00092.28 EMC79356.1 - 6.5e-35 120.9 0.0 1e-34 120.3 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain fn3 PF00041.21 EMC79356.1 - 1.7e-22 79.5 0.9 2.5e-10 40.6 0.1 2.3 2 0 0 2 2 2 2 Fibronectin type III domain VWA_2 PF13519.6 EMC79356.1 - 2.6e-14 53.8 0.0 5.2e-14 52.8 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Pur_ac_phosph_N PF16656.5 EMC79356.1 - 3.2e-05 24.4 2.1 0.13 12.9 0.1 3.2 3 1 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 EMC79356.1 - 4.3e-05 23.8 0.0 0.013 15.8 0.0 2.3 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.9 EMC79356.1 - 0.0022 18.3 0.0 0.13 12.7 0.0 2.8 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2369) Big_5 PF13205.6 EMC79356.1 - 0.027 15.2 1.9 2.8 8.7 0.0 3.4 3 1 0 3 3 3 0 Bacterial Ig-like domain DUF1410 PF07198.11 EMC79356.1 - 0.036 14.6 0.0 2.3 8.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1410) DUF4998 PF16389.5 EMC79356.1 - 0.043 13.4 0.0 2.1 7.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function DJ-1_PfpI PF01965.24 EMC79356.1 - 0.052 13.4 0.0 0.092 12.5 0.0 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family VWA_CoxE PF05762.14 EMC79356.1 - 0.13 11.7 0.1 10 5.4 0.0 2.3 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein DUF3523 PF12037.8 EMC79357.1 - 9.9e-89 297.2 31.6 1.5e-88 296.6 31.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3523) AAA PF00004.29 EMC79357.1 - 9.5e-17 61.7 0.1 3.2e-16 60.0 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EMC79357.1 - 0.00026 20.8 0.0 0.00071 19.3 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 EMC79357.1 - 0.00058 19.3 0.2 0.0043 16.5 0.0 2.5 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_lid_3 PF17862.1 EMC79357.1 - 0.00086 19.1 0.1 0.0031 17.3 0.1 2.0 1 0 0 1 1 1 1 AAA+ lid domain AAA_24 PF13479.6 EMC79357.1 - 0.0019 17.9 0.0 0.0043 16.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EMC79357.1 - 0.0037 17.6 8.4 0.11 12.9 0.0 3.6 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EMC79357.1 - 0.0054 16.7 3.3 0.044 13.8 0.0 3.2 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EMC79357.1 - 0.011 15.9 0.0 0.011 15.9 0.0 2.8 2 1 0 2 2 1 0 AAA domain Sigma54_activ_2 PF14532.6 EMC79357.1 - 0.014 15.5 0.3 0.045 13.9 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain ATPase PF06745.13 EMC79357.1 - 0.024 14.0 0.0 0.024 14.0 0.0 2.1 2 1 0 2 2 1 0 KaiC RNA_helicase PF00910.22 EMC79357.1 - 0.033 14.6 0.0 0.082 13.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase TsaE PF02367.17 EMC79357.1 - 0.045 13.8 0.1 0.19 11.8 0.0 2.1 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EMC79357.1 - 0.11 12.1 0.0 0.24 10.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Zot PF05707.12 EMC79357.1 - 0.19 11.3 2.4 2.7 7.6 0.0 3.1 2 1 1 3 3 3 0 Zonular occludens toxin (Zot) AAA_18 PF13238.6 EMC79357.1 - 0.33 11.5 0.0 0.33 11.5 0.0 2.6 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EMC79357.1 - 0.34 11.2 0.0 0.34 11.2 0.0 3.5 3 1 0 3 3 2 0 AAA domain AAA_28 PF13521.6 EMC79357.1 - 0.53 10.5 0.0 0.53 10.5 0.0 3.4 3 1 1 4 4 4 0 AAA domain AAA_11 PF13086.6 EMC79357.1 - 0.73 9.6 0.0 0.73 9.6 0.0 2.8 2 1 0 2 2 1 0 AAA domain TFIIA PF03153.13 EMC79357.1 - 4.7 7.1 20.0 7.1 6.5 20.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BORG_CEP PF14957.6 EMC79357.1 - 6.4 8.0 7.2 16 6.7 7.2 1.7 1 0 0 1 1 1 0 Cdc42 effector TMEM240 PF15207.6 EMC79358.1 - 2.7e-74 248.7 1.5 3.1e-74 248.4 1.5 1.0 1 0 0 1 1 1 1 TMEM240 family DUF3306 PF11748.8 EMC79359.1 - 0.16 12.8 8.1 0.26 12.2 8.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) RecR PF02132.15 EMC79360.1 - 0.38 10.3 3.3 3.1 7.4 3.3 2.2 1 1 0 1 1 1 0 RecR protein ATG16 PF08614.11 EMC79361.1 - 3.5 7.8 36.6 0.32 11.2 21.9 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) JIP_LZII PF16471.5 EMC79361.1 - 4.9 7.4 20.8 0.076 13.2 2.5 4.0 2 2 1 4 4 4 0 JNK-interacting protein leucine zipper II Pkinase PF00069.25 EMC79362.1 - 2.2e-57 194.4 0.0 2.2e-57 194.4 0.0 2.0 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC79362.1 - 8.6e-28 97.3 1.4 1.5e-27 96.5 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC79362.1 - 4.7e-06 26.1 0.3 0.0004 19.8 0.3 2.5 1 1 0 1 1 1 1 Kinase-like NAD_kinase PF01513.21 EMC79364.1 - 1.8e-66 224.3 0.1 2.1e-66 224.1 0.1 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EMC79364.1 - 0.033 13.8 0.0 0.078 12.6 0.0 1.6 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain TMEM52 PF14979.6 EMC79366.1 - 8.5e-37 126.4 2.8 9.4e-37 126.2 2.8 1.0 1 0 0 1 1 1 1 Transmembrane 52 DUF1573 PF07610.11 EMC79367.1 - 0.00045 20.2 0.0 0.43 10.6 0.0 3.6 3 1 1 4 4 4 1 Protein of unknown function (DUF1573) ASH PF15780.5 EMC79367.1 - 0.0013 18.9 0.0 0.35 11.1 0.0 3.1 3 0 0 3 3 3 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF5475 PF17569.2 EMC79367.1 - 0.045 14.1 0.0 0.17 12.3 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5475) fn3_5 PF06280.12 EMC79367.1 - 0.074 13.8 0.0 0.19 12.5 0.0 1.7 2 0 0 2 2 2 0 Fn3-like domain Motile_Sperm PF00635.26 EMC79367.1 - 0.11 12.3 0.0 22 4.9 0.0 2.7 3 0 0 3 3 3 0 MSP (Major sperm protein) domain PapD-like PF14874.6 EMC79367.1 - 0.12 12.5 0.0 0.39 10.9 0.0 1.8 2 0 0 2 2 2 0 Flagellar-associated PapD-like ASH PF15780.5 EMC79368.1 - 3.3e-05 24.0 0.1 1.9 8.8 0.0 3.5 3 0 0 3 3 3 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 EMC79368.1 - 0.00017 21.7 0.0 0.98 9.6 0.0 2.7 2 0 0 2 2 2 2 Flagellar-associated PapD-like TMEM131_like PF12371.8 EMC79368.1 - 0.0019 18.4 0.0 0.54 10.5 0.0 3.2 3 0 0 3 3 3 1 Transmembrane protein 131-like DUF2868 PF11067.8 EMC79368.1 - 6.4 6.2 9.1 14 5.1 9.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) Neur_chan_LBD PF02931.23 EMC79369.1 - 1.2e-48 165.4 0.1 2e-48 164.7 0.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC79369.1 - 8.6e-34 117.6 6.8 6.2e-31 108.3 2.6 2.3 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Herpes_glycoH_C PF17488.2 EMC79369.1 - 0.038 13.8 0.3 7.9 6.3 0.4 2.3 2 0 0 2 2 2 0 Herpesvirus glycoprotein H C-terminal domain Pkinase PF00069.25 EMC79370.1 - 4.4e-64 216.4 0.0 5.7e-64 216.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC79370.1 - 2.6e-33 115.4 0.0 4.1e-33 114.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.24 EMC79370.1 - 2.7e-16 59.3 0.0 5.8e-16 58.2 0.0 1.6 1 0 0 1 1 1 1 PB1 domain C1_1 PF00130.22 EMC79370.1 - 1.2e-14 53.9 6.7 2.4e-14 52.9 6.7 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 EMC79370.1 - 1e-05 26.1 1.6 2.5e-05 24.9 1.6 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 EMC79370.1 - 3.4e-05 23.3 0.0 6.3e-05 22.4 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EMC79370.1 - 0.021 13.8 0.0 0.032 13.2 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 EMC79370.1 - 0.023 14.1 0.0 0.059 12.7 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family C1_2 PF03107.16 EMC79370.1 - 0.034 14.5 2.5 0.077 13.3 2.5 1.6 1 0 0 1 1 1 0 C1 domain FTA2 PF13095.6 EMC79370.1 - 0.039 13.6 0.1 1.1 8.8 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EMC79370.1 - 0.051 13.5 0.1 0.24 11.3 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family DZR PF12773.7 EMC79370.1 - 4.5 7.4 5.5 1.1 9.3 2.2 1.8 2 0 0 2 2 1 0 Double zinc ribbon UBZ_FAAP20 PF15750.5 EMC79371.1 - 5.6e-18 64.6 2.8 1e-17 63.8 2.8 1.5 1 0 0 1 1 1 1 Ubiquitin-binding zinc-finger FANCA_interact PF15751.5 EMC79371.1 - 1.5e-05 25.4 0.2 3.5e-05 24.3 0.2 1.7 1 1 0 1 1 1 1 FAAP20 FANCA interaction domain Rer1 PF03248.13 EMC79372.1 - 7.2e-78 260.2 8.2 8.2e-78 260.0 8.2 1.0 1 0 0 1 1 1 1 Rer1 family Bestrophin PF01062.21 EMC79372.1 - 0.013 14.9 0.2 0.024 14.0 0.2 1.4 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel DUF2208 PF09973.9 EMC79372.1 - 0.84 9.2 8.4 0.14 11.8 0.6 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) Pex2_Pex12 PF04757.14 EMC79373.1 - 9.2e-35 120.3 1.9 1.1e-34 120.0 1.9 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.6 EMC79373.1 - 4.4e-09 36.5 15.7 8.1e-09 35.7 15.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EMC79373.1 - 8.3e-09 35.2 12.7 1.3e-08 34.5 12.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC79373.1 - 6.6e-08 32.3 11.3 1.1e-07 31.5 11.3 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EMC79373.1 - 7.6e-08 32.1 13.8 1.5e-07 31.2 13.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC79373.1 - 1.5e-06 28.1 7.5 1.5e-06 28.1 7.5 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EMC79373.1 - 1.7e-06 27.8 13.5 3.6e-06 26.7 13.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMC79373.1 - 2.6e-05 24.4 10.9 6.3e-05 23.2 10.9 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EMC79373.1 - 3.5e-05 23.7 12.1 6.4e-05 22.8 12.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EMC79373.1 - 0.014 15.5 12.3 0.06 13.5 12.5 2.0 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF3290 PF11694.8 EMC79373.1 - 0.023 14.7 0.1 0.045 13.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) DUF3605 PF12239.8 EMC79373.1 - 0.034 14.5 0.8 0.041 14.2 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3605) zf-RING_6 PF14835.6 EMC79373.1 - 0.039 13.8 4.3 0.069 13.0 4.3 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein TMCCDC2 PF15844.5 EMC79373.1 - 0.07 13.1 0.8 0.68 9.9 0.1 2.5 3 0 0 3 3 3 0 Transmembrane and coiled-coil domain-containing protein 2 zf-RING_4 PF14570.6 EMC79373.1 - 0.085 12.7 10.1 0.17 11.7 10.1 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 EMC79373.1 - 0.21 11.4 4.9 0.49 10.2 3.0 2.5 2 1 0 2 2 2 0 RING-like zinc finger zf-ANAPC11 PF12861.7 EMC79373.1 - 0.36 10.9 6.8 0.74 9.9 6.5 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Lig_chan PF00060.26 EMC79374.1 - 5.8e-40 136.5 0.4 9.5e-40 135.9 0.4 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 EMC79374.1 - 1e-36 125.6 0.0 2e-36 124.7 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 EMC79374.1 - 6.2e-19 68.3 0.0 9e-19 67.8 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Borrelia_orfA PF02414.15 EMC79374.1 - 0.0041 16.8 0.2 0.006 16.3 0.2 1.1 1 0 0 1 1 1 1 Borrelia ORF-A Fumble PF03630.14 EMC79375.1 - 2e-128 428.2 3.5 2.5e-128 427.9 3.5 1.1 1 0 0 1 1 1 1 Fumble DUF89 PF01937.19 EMC79375.1 - 2e-56 191.5 0.0 3.2e-56 190.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF89 vATP-synt_E PF01991.18 EMC79375.1 - 0.033 13.6 0.0 0.097 12.1 0.0 1.8 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit HLH PF00010.26 EMC79376.1 - 3.8e-10 39.6 0.5 6.1e-10 38.9 0.5 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 EMC79376.1 - 7.9e-10 38.8 0.2 1.2e-09 38.2 0.2 1.3 1 0 0 1 1 1 1 Hairy Orange DUF5630 PF18632.1 EMC79376.1 - 0.024 14.0 0.9 0.028 13.8 0.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5630) HLH PF00010.26 EMC79377.1 - 3.4e-15 55.7 2.1 6.5e-15 54.8 2.1 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 EMC79377.1 - 7.4e-05 22.9 0.2 0.00012 22.2 0.2 1.4 1 0 0 1 1 1 1 Hairy Orange HLH PF00010.26 EMC79378.1 - 6.9e-16 57.9 2.4 1.1e-15 57.3 2.4 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 EMC79378.1 - 5.9e-07 29.6 1.4 1.1e-06 28.8 1.4 1.4 1 0 0 1 1 1 1 Hairy Orange TNFR_c6 PF00020.18 EMC79379.1 - 7.2e-09 35.9 23.7 2e-07 31.3 8.2 3.1 3 0 0 3 3 3 3 TNFR/NGFR cysteine-rich region Ephrin_rec_like PF07699.13 EMC79379.1 - 0.013 15.3 21.3 0.02 14.6 6.4 2.5 2 1 0 2 2 2 0 Putative ephrin-receptor like RANK_CRD_2 PF18278.1 EMC79379.1 - 0.16 12.1 7.1 0.42 10.8 7.1 1.8 1 0 0 1 1 1 0 Receptor activator of the NF-KB cysteine-rich repeat domain 2 zf-C2H2 PF00096.26 EMC79382.1 - 3.7e-35 118.4 76.1 6.2e-07 29.5 1.4 9.5 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC79382.1 - 2.3e-22 77.8 68.2 0.00099 19.8 0.6 9.6 9 0 0 9 9 9 7 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC79382.1 - 6e-17 61.2 68.2 3.5e-08 33.5 1.2 9.7 11 0 0 11 11 10 4 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EMC79382.1 - 1.3e-06 28.5 46.0 0.18 12.1 0.3 9.3 9 0 0 9 9 9 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMC79382.1 - 1.9e-06 27.7 56.9 0.07 13.1 0.2 8.3 8 0 0 8 8 8 6 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EMC79382.1 - 4.9e-06 26.2 47.0 0.07 12.9 2.8 7.4 8 0 0 8 8 7 5 zinc-finger C2H2-type zf-H2C2_5 PF13909.6 EMC79382.1 - 5.2e-05 22.9 2.4 5.2e-05 22.9 2.4 6.8 8 1 0 8 8 7 4 C2H2-type zinc-finger domain zf-BED PF02892.15 EMC79382.1 - 0.00074 19.5 0.5 0.00074 19.5 0.5 7.0 3 2 2 5 5 4 1 BED zinc finger SET PF00856.28 EMC79382.1 - 0.0053 17.2 0.8 0.12 12.8 0.0 3.3 3 1 0 3 3 3 1 SET domain zinc_ribbon_15 PF17032.5 EMC79382.1 - 0.009 16.7 26.0 0.25 12.1 0.2 5.6 4 1 1 5 5 5 2 zinc-ribbon family Ribosomal_L31 PF01197.18 EMC79382.1 - 1.1 9.5 9.4 7 7.0 1.2 4.3 3 1 1 4 4 4 0 Ribosomal protein L31 PyrI_C PF02748.15 EMC79382.1 - 1.2 9.1 23.6 0.68 9.9 0.1 5.7 5 1 1 6 6 6 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain GAGA PF09237.11 EMC79382.1 - 1.9 8.3 21.4 2.6 7.9 0.5 5.3 4 1 2 6 6 5 0 GAGA factor zf-ribbon_3 PF13248.6 EMC79382.1 - 1.9 8.0 6.1 17 5.0 0.1 3.7 3 0 0 3 3 3 0 zinc-ribbon domain zf-LYAR PF08790.11 EMC79382.1 - 4.9 7.2 15.8 4.4 7.3 0.3 5.3 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger zf-C2H2_8 PF15909.5 EMC79382.1 - 9.7 6.6 31.9 0.09 13.1 9.9 4.2 3 1 1 4 4 4 0 C2H2-type zinc ribbon RhoGEF PF00621.20 EMC79383.1 - 1.1e-36 126.8 1.9 1.5e-36 126.3 1.9 1.2 1 0 0 1 1 1 1 RhoGEF domain SH3_9 PF14604.6 EMC79383.1 - 6e-12 45.2 0.3 1.8e-11 43.7 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EMC79383.1 - 9.8e-09 34.7 0.4 2.4e-08 33.4 0.1 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EMC79383.1 - 1.5e-07 30.9 0.0 3.6e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.29 EMC79383.1 - 0.00021 21.8 0.0 0.00056 20.4 0.0 1.8 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 EMC79383.1 - 0.0038 17.2 0.1 0.031 14.3 0.0 2.5 2 1 0 2 2 2 1 PH domain hSac2 PF12456.8 EMC79385.1 - 6e-27 93.6 0.0 1e-26 92.9 0.0 1.3 1 0 0 1 1 1 1 Inositol phosphatase ANAPC4_WD40 PF12894.7 EMC79386.1 - 1.6e-11 44.4 0.6 0.0024 18.1 0.0 6.6 2 2 6 8 8 8 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EMC79386.1 - 2e-10 41.1 4.5 0.0047 17.7 0.0 7.7 7 1 0 7 7 7 2 WD domain, G-beta repeat eIF2A PF08662.11 EMC79386.1 - 1.1e-07 31.9 0.1 1.7 8.5 0.0 4.5 2 2 2 4 4 4 4 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.12 EMC79386.1 - 0.04 11.9 4.9 0.83 7.6 0.0 3.0 2 1 0 3 3 3 0 IKI3 family PD40 PF07676.12 EMC79386.1 - 0.041 13.8 0.8 38 4.4 0.0 3.8 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Lactonase PF10282.9 EMC79386.1 - 0.23 10.7 0.0 13 4.9 0.0 2.8 3 0 0 3 3 3 0 Lactonase, 7-bladed beta-propeller GFO_IDH_MocA_C PF02894.17 EMC79387.1 - 0.00029 20.8 0.0 0.00054 19.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Atg14 PF10186.9 EMC79388.1 - 0.0029 16.8 16.5 0.0037 16.4 16.5 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 TMF_TATA_bd PF12325.8 EMC79388.1 - 0.019 15.2 19.5 0.019 15.2 19.5 2.1 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Tektin PF03148.14 EMC79388.1 - 0.023 13.5 18.2 0.016 14.0 5.6 2.4 1 1 1 2 2 2 0 Tektin family DUF2922 PF11148.8 EMC79388.1 - 0.034 13.9 0.1 0.085 12.6 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2922) ERM PF00769.19 EMC79388.1 - 0.048 13.5 24.3 0.066 13.0 24.3 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Phage_GP20 PF06810.11 EMC79388.1 - 0.1 12.4 11.3 0.1 12.4 1.3 2.4 1 1 1 2 2 2 0 Phage minor structural protein GP20 DUF3835 PF12927.7 EMC79388.1 - 0.22 12.4 0.2 0.22 12.4 0.2 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF3835) NleF_casp_inhib PF16809.5 EMC79388.1 - 0.46 10.4 5.3 0.34 10.8 2.3 2.2 1 1 1 2 2 2 0 NleF caspase inhibitor Spc7 PF08317.11 EMC79388.1 - 0.64 8.9 24.5 0.51 9.2 23.1 1.6 1 1 1 2 2 2 0 Spc7 kinetochore protein DegS PF05384.11 EMC79388.1 - 0.67 9.4 21.0 1.6 8.2 0.4 3.0 1 1 2 3 3 3 0 Sensor protein DegS MPS2 PF17060.5 EMC79388.1 - 1.2 8.3 14.9 1 8.5 13.9 1.4 1 1 0 1 1 1 0 Monopolar spindle protein 2 Uso1_p115_C PF04871.13 EMC79388.1 - 1.4 9.3 20.6 2.5 8.5 12.8 2.3 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Cnn_1N PF07989.11 EMC79388.1 - 1.9 8.7 19.4 10 6.3 13.0 3.0 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 ATG16 PF08614.11 EMC79388.1 - 2.2 8.5 27.6 2 8.6 7.3 2.5 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) PIN_8 PF18476.1 EMC79388.1 - 2.7 7.8 11.9 0.12 12.2 3.0 2.0 1 1 1 2 2 2 0 PIN like domain CENP-F_leu_zip PF10473.9 EMC79388.1 - 4.3 7.4 29.9 0.53 10.3 23.4 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4795 PF16043.5 EMC79388.1 - 4.5 6.8 19.4 12 5.4 19.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Csm1_N PF18504.1 EMC79388.1 - 7.1 7.0 18.7 11 6.4 7.3 2.9 1 1 1 2 2 2 0 Csm1 N-terminal domain SlyX PF04102.12 EMC79388.1 - 8.2 7.1 26.5 1.7 9.3 8.5 3.2 2 1 1 3 3 2 0 SlyX B3_4 PF03483.17 EMC79389.1 - 2.3e-09 37.2 0.0 5.1e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 B3/4 domain LRR_4 PF12799.7 EMC79389.1 - 0.0042 17.5 0.0 0.033 14.6 0.0 2.6 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMC79389.1 - 0.035 13.9 0.0 0.1 12.4 0.0 1.8 1 0 0 1 1 1 0 Leucine rich repeat DFF40 PF09230.10 EMC79390.1 - 5e-89 297.8 0.7 5.7e-89 297.6 0.7 1.0 1 0 0 1 1 1 1 DNA fragmentation factor 40 kDa DUF2554 PF10829.8 EMC79390.1 - 0.085 13.3 0.0 0.2 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2554) UPF0688 PF15772.5 EMC79391.1 - 1.1e-38 133.9 3.9 1.3e-38 133.6 3.9 1.0 1 0 0 1 1 1 1 UPF0688 family AJAP1_PANP_C PF15298.6 EMC79392.1 - 4.6e-47 160.7 0.4 5.2e-47 160.6 0.4 1.0 1 0 0 1 1 1 1 AJAP1/PANP C-terminus Stomagen PF16851.5 EMC79392.1 - 0.016 15.2 0.0 0.026 14.5 0.0 1.3 1 0 0 1 1 1 0 Stomagen Aldo_ket_red PF00248.21 EMC79393.1 - 2.7e-67 227.0 0.0 3.1e-67 226.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family SMI1_KNR4 PF09346.10 EMC79393.1 - 0.21 12.0 0.0 0.36 11.2 0.0 1.4 1 0 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) Ribosomal_L22e PF01776.17 EMC79394.1 - 5.3e-41 139.4 2.3 6.2e-41 139.2 2.3 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family zf-RING_5 PF14634.6 EMC79395.1 - 0.00018 21.4 15.1 0.00018 21.4 15.1 3.4 3 0 0 3 3 3 1 zinc-RING finger domain AIP3 PF03915.13 EMC79395.1 - 0.00021 20.5 1.5 0.00021 20.5 1.5 1.5 2 0 0 2 2 2 1 Actin interacting protein 3 zf-C3HC4 PF00097.25 EMC79395.1 - 0.00063 19.6 14.8 0.00063 19.6 14.8 3.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC79395.1 - 0.0014 18.6 14.0 0.0014 18.6 14.0 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-B_box PF00643.24 EMC79395.1 - 0.002 18.2 10.4 0.002 18.2 10.4 3.9 4 0 0 4 4 4 1 B-box zinc finger IL10 PF00726.17 EMC79395.1 - 0.009 15.5 3.2 0.019 14.5 0.3 2.5 2 1 0 2 2 2 1 Interleukin 10 DUF3400 PF11880.8 EMC79395.1 - 0.025 14.1 0.5 0.053 13.1 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3400) Tex_N PF09371.10 EMC79395.1 - 0.56 9.9 6.7 0.49 10.0 1.1 2.1 2 0 0 2 2 2 0 Tex-like protein N-terminal domain ICMT PF04140.14 EMC79396.1 - 1.2e-34 118.6 0.1 1.8e-34 118.0 0.1 1.2 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EMC79396.1 - 3.5e-08 33.8 0.5 5.2e-08 33.2 0.5 1.3 1 0 0 1 1 1 1 Phospholipid methyltransferase DUF1295 PF06966.12 EMC79396.1 - 0.015 14.8 0.2 0.017 14.6 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) 4HBT PF03061.22 EMC79397.1 - 4.3e-24 84.7 1.2 3.9e-16 59.2 0.1 2.1 2 0 0 2 2 2 2 Thioesterase superfamily tRNA_anti-codon PF01336.25 EMC79397.1 - 7.1e-05 22.7 0.0 0.0018 18.2 0.0 2.3 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain NINJA_B PF16136.5 EMC79397.1 - 0.37 11.2 3.1 0.75 10.2 3.1 1.4 1 0 0 1 1 1 0 Putative nuclear localisation signal CLP1_P PF16575.5 EMC79398.1 - 6.1e-15 55.5 0.0 8.9e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Clp1 PF06807.14 EMC79398.1 - 0.11 12.9 0.0 0.27 11.7 0.0 1.6 1 0 0 1 1 1 0 Pre-mRNA cleavage complex II protein Clp1 ANF_receptor PF01094.28 EMC79399.1 - 4.7e-47 160.8 0.0 5.8e-47 160.5 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.6 EMC79399.1 - 0.00065 19.5 0.0 0.0014 18.4 0.0 1.5 2 0 0 2 2 2 1 Periplasmic binding protein MSP1a PF11670.8 EMC79399.1 - 1.3 8.3 5.6 0.6 9.4 0.8 2.4 3 0 0 3 3 3 0 Major surface protein 1a (MSP1a) zf-H2C2_2 PF13465.6 EMC79400.1 - 9.3e-43 142.8 68.2 1.4e-09 38.0 1.9 10.3 10 0 0 10 10 10 8 Zinc-finger double domain zf-C2H2 PF00096.26 EMC79400.1 - 4.5e-34 115.0 60.7 4e-06 27.0 1.9 8.6 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC79400.1 - 4.3e-25 86.2 63.2 0.0012 19.4 1.6 9.1 9 0 0 9 9 9 8 C2H2-type zinc finger zf-met PF12874.7 EMC79400.1 - 1.3e-08 34.9 43.1 0.043 14.2 0.9 7.8 8 0 0 8 8 7 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMC79400.1 - 7.1e-08 32.6 35.7 0.0033 17.7 0.4 7.7 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 EMC79400.1 - 8.1e-08 32.4 37.8 0.0011 19.3 1.1 5.2 4 1 1 5 5 5 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 EMC79400.1 - 2.4e-07 30.6 56.3 6.1e-05 22.9 2.2 7.8 8 0 0 8 8 7 5 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EMC79400.1 - 3.1e-06 26.8 4.8 7.8e-05 22.4 0.6 7.0 7 0 0 7 7 7 2 zinc-finger C2H2-type GAGA PF09237.11 EMC79400.1 - 7.2e-05 22.5 25.9 0.0098 15.7 0.5 5.1 2 1 4 6 6 6 3 GAGA factor zf-H2C2_5 PF13909.6 EMC79400.1 - 0.00011 21.8 42.7 0.0072 16.1 0.6 7.6 8 0 0 8 8 7 3 C2H2-type zinc-finger domain zf-MYST PF17772.1 EMC79400.1 - 0.011 15.4 17.1 1.5 8.5 1.0 5.6 5 2 1 6 6 6 0 MYST family zinc finger domain zinc_ribbon_15 PF17032.5 EMC79400.1 - 0.018 15.8 27.0 0.28 12.0 0.9 4.6 4 1 0 4 4 4 0 zinc-ribbon family zf-C2H2_2 PF12756.7 EMC79400.1 - 0.028 14.7 44.5 0.11 12.8 7.9 7.1 2 2 2 5 5 5 0 C2H2 type zinc-finger (2 copies) DUF2387 PF09526.10 EMC79400.1 - 0.071 13.3 0.4 0.071 13.3 0.4 3.6 4 1 1 5 5 4 0 Probable metal-binding protein (DUF2387) DUF1857 PF08982.11 EMC79400.1 - 0.17 11.8 0.4 7.7 6.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1857) DUF4226 PF10774.9 EMC79400.1 - 0.17 12.2 0.1 18 5.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4226) Zn-C2H2_12 PF18112.1 EMC79400.1 - 0.17 12.4 12.3 24 5.5 0.2 5.0 4 0 0 4 4 4 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_8 PF15909.5 EMC79400.1 - 0.2 12.0 34.3 0.26 11.6 2.6 4.8 1 1 4 5 5 5 0 C2H2-type zinc ribbon Zn-ribbon_8 PF09723.10 EMC79400.1 - 0.6 10.3 40.6 1.9 8.7 1.3 7.2 5 2 1 6 6 5 0 Zinc ribbon domain zf-C2H2_3rep PF18868.1 EMC79400.1 - 1.1 10.0 30.7 0.74 10.5 0.9 6.3 2 2 3 5 5 5 0 Zinc finger C2H2-type, 3 repeats DUF3268 PF11672.8 EMC79400.1 - 1.6 9.1 21.8 0.52 10.7 0.3 4.2 3 2 1 4 4 4 0 zinc-finger-containing domain zf-FCS PF06467.14 EMC79400.1 - 3 7.9 21.0 17 5.4 0.0 5.8 4 1 1 5 5 5 0 MYM-type Zinc finger with FCS sequence motif Elf1 PF05129.13 EMC79400.1 - 4.7 7.3 34.7 0.46 10.6 2.1 5.9 2 2 4 6 6 6 0 Transcription elongation factor Elf1 like zf_UBZ PF18439.1 EMC79400.1 - 5.6 6.7 31.1 8.3 6.1 0.1 7.7 8 0 0 8 8 8 0 Ubiquitin-Binding Zinc Finger CpXC PF14353.6 EMC79400.1 - 8.3 6.5 30.0 2.7 8.0 0.2 7.2 3 3 4 7 7 7 0 CpXC protein Kelch_6 PF13964.6 EMC79401.1 - 1.8e-13 50.2 0.0 3.5e-10 39.8 0.0 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 EMC79401.1 - 7.6e-13 47.8 1.7 1.4e-08 34.2 0.1 2.7 2 1 1 3 3 3 2 Kelch motif Kelch_2 PF07646.15 EMC79401.1 - 1.2e-10 40.9 0.3 6.2e-08 32.3 0.0 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 EMC79401.1 - 2.4e-10 40.5 0.1 1.9e-05 24.8 0.1 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_4 PF13418.6 EMC79401.1 - 4.6e-06 26.5 0.0 0.021 14.8 0.0 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC79401.1 - 0.0044 17.0 0.6 0.03 14.3 0.2 2.2 2 0 0 2 2 2 1 Kelch motif PQQ_3 PF13570.6 EMC79401.1 - 0.091 13.3 0.6 0.23 12.0 0.1 2.0 3 0 0 3 3 3 0 PQQ-like domain PHD PF00628.29 EMC79402.1 - 3.3e-08 33.3 8.2 5.8e-08 32.5 8.2 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EMC79402.1 - 3.7e-06 26.4 5.3 6.8e-06 25.5 5.3 1.4 1 0 0 1 1 1 1 PHD-finger zf-C4H2 PF10146.9 EMC79402.1 - 0.0011 19.3 0.2 0.0016 18.8 0.2 1.2 1 0 0 1 1 1 1 Zinc finger-containing protein zf-HC5HC2H PF13771.6 EMC79402.1 - 0.014 15.6 1.1 0.031 14.5 1.1 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain C1_1 PF00130.22 EMC79402.1 - 0.017 15.0 2.0 0.017 15.0 2.0 1.8 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) FYVE_2 PF02318.16 EMC79402.1 - 0.11 12.7 3.5 0.25 11.6 3.5 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger zf-RING_9 PF13901.6 EMC79402.1 - 0.75 9.7 6.8 1.4 8.9 6.8 1.3 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon C1_2 PF03107.16 EMC79402.1 - 8.6 6.8 7.9 17 5.8 2.3 2.5 3 0 0 3 3 3 0 C1 domain DUF3395 PF11875.8 EMC79403.1 - 9.4e-47 158.8 0.3 9.4e-47 158.8 0.3 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 EMC79403.1 - 2e-06 27.8 0.4 8.4e-06 25.8 0.1 2.2 2 0 0 2 2 2 1 DnaJ domain DUF4736 PF15883.5 EMC79403.1 - 0.092 12.5 1.6 0.16 11.7 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4736) GDA1_CD39 PF01150.17 EMC79403.1 - 0.13 10.9 0.1 0.19 10.3 0.1 1.1 1 0 0 1 1 1 0 GDA1/CD39 (nucleoside phosphatase) family CG-1 PF03859.16 EMC79404.1 - 2.2e-42 143.5 2.8 6.6e-42 142.0 2.8 1.9 1 0 0 1 1 1 1 CG-1 domain TIG PF01833.24 EMC79404.1 - 1.4e-10 41.1 1.5 3.1e-10 40.0 0.1 2.4 2 0 0 2 2 2 1 IPT/TIG domain Ank_2 PF12796.7 EMC79404.1 - 1.2e-09 38.6 0.2 5.4e-05 23.7 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC79404.1 - 3.9e-05 23.8 0.8 0.55 10.6 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC79404.1 - 0.00026 21.2 0.6 0.97 10.2 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat IQ PF00612.27 EMC79404.1 - 0.0026 17.4 19.4 0.83 9.6 0.3 5.4 5 0 0 5 5 5 3 IQ calmodulin-binding motif Ank_4 PF13637.6 EMC79404.1 - 0.0059 17.2 1.2 0.72 10.5 0.1 3.1 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 EMC79404.1 - 0.014 15.8 0.4 3.5 8.2 0.1 2.8 2 0 0 2 2 2 0 Ankyrin repeat Synaptobrevin PF00957.21 EMC79405.1 - 1e-34 118.2 4.1 1.1e-34 118.0 4.1 1.0 1 0 0 1 1 1 1 Synaptobrevin MCU PF04678.13 EMC79405.1 - 0.012 15.7 0.1 0.013 15.6 0.1 1.0 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF3619 PF12279.8 EMC79405.1 - 0.037 14.4 0.2 0.047 14.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) ASFV_J13L PF05568.11 EMC79405.1 - 6.1 6.6 7.7 7.8 6.2 7.2 1.4 1 1 0 1 1 1 0 African swine fever virus J13L protein Urotensin_II PF02083.15 EMC79406.1 - 1.5e-06 27.5 1.0 2.7e-06 26.7 1.0 1.4 1 0 0 1 1 1 1 Urotensin II DUF1418 PF07214.12 EMC79407.1 - 0.12 12.2 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1418) DJ-1_PfpI PF01965.24 EMC79408.1 - 1.4e-52 177.8 0.0 1.6e-52 177.6 0.0 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 EMC79408.1 - 0.00063 19.5 0.0 0.053 13.2 0.0 2.2 1 1 1 2 2 2 2 ThiJ/PfpI family-like GATase_3 PF07685.14 EMC79408.1 - 0.015 14.9 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain Inhibitor_Mig-6 PF11555.8 EMC79409.1 - 1.1e-14 54.3 8.9 1.1e-14 54.3 8.9 3.5 3 0 0 3 3 3 2 EGFR receptor inhibitor Mig-6 GTPase_binding PF09027.10 EMC79409.1 - 0.00021 21.2 0.0 0.00057 19.8 0.0 1.7 1 0 0 1 1 1 1 GTPase binding cIII PF08134.11 EMC79409.1 - 0.084 12.6 0.3 0.17 11.7 0.3 1.4 1 0 0 1 1 1 0 cIII protein family MFS_2 PF13347.6 EMC79410.1 - 3.8e-09 35.6 0.9 3.8e-09 35.6 0.9 2.4 2 0 0 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.7 EMC79410.1 - 6.2 5.6 9.1 5 5.9 0.0 2.9 3 1 1 4 4 4 0 MFS_1 like family Hormone_2 PF00123.20 EMC79411.1 - 9.5e-16 57.4 0.4 1.6e-15 56.7 0.4 1.4 1 0 0 1 1 1 1 Peptide hormone Pkinase_Tyr PF07714.17 EMC79412.1 - 6.4e-93 310.8 0.0 8.2e-93 310.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC79412.1 - 1.1e-45 156.1 0.0 1.4e-45 155.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 EMC79412.1 - 3.2e-28 97.7 0.2 6.2e-28 96.7 0.2 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 EMC79412.1 - 7.3e-20 70.3 0.4 3.3e-19 68.2 0.1 2.2 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EMC79412.1 - 6.3e-15 54.8 0.0 1.9e-14 53.2 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC79412.1 - 4.6e-11 42.2 0.1 1.4e-10 40.7 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain Haspin_kinase PF12330.8 EMC79412.1 - 0.0021 17.1 0.0 0.0038 16.2 0.0 1.4 1 1 0 1 1 1 1 Haspin like kinase domain SH3_10 PF17902.1 EMC79412.1 - 0.0042 17.1 0.0 0.0089 16.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_3 PF08239.11 EMC79412.1 - 0.014 15.6 0.1 0.033 14.5 0.1 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain zf-RING_14 PF17978.1 EMC79412.1 - 0.057 13.9 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain YdjC PF04794.12 EMC79412.1 - 0.061 13.3 0.0 0.093 12.7 0.0 1.2 1 0 0 1 1 1 0 YdjC-like protein hSH3 PF14603.6 EMC79412.1 - 0.12 12.9 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 Helically-extended SH3 domain Thymidylat_synt PF00303.19 EMC79413.1 - 2.3e-104 348.3 0.0 2.5e-104 348.2 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase Clusterin PF01093.17 EMC79414.1 - 4.4e-167 556.5 9.3 5e-167 556.3 9.3 1.0 1 0 0 1 1 1 1 Clusterin Gifsy-2 PF13856.6 EMC79414.1 - 0.0063 16.8 0.1 0.04 14.3 0.0 2.3 1 1 1 2 2 2 1 ATP-binding sugar transporter from pro-phage Carbpep_Y_N PF05388.11 EMC79414.1 - 0.0096 16.5 0.9 1.2 9.6 0.5 2.9 3 0 0 3 3 3 1 Carboxypeptidase Y pro-peptide Sulfatase_C PF14707.6 EMC79414.1 - 0.13 13.0 8.9 1.5 9.6 0.1 3.5 2 2 1 3 3 3 0 C-terminal region of aryl-sulfatase Toxin-deaminase PF14424.6 EMC79414.1 - 0.23 11.6 2.1 0.55 10.3 2.0 1.7 1 1 0 1 1 1 0 The BURPS668_1122 family of deaminases P2 PF07194.11 EMC79414.1 - 0.55 10.3 4.5 20 5.3 0.0 3.6 3 1 0 3 3 3 0 P2 response regulator binding domain ALIX_LYPXL_bnd PF13949.6 EMC79414.1 - 1.8 7.8 15.1 4.9 6.4 6.3 3.7 2 2 1 4 4 4 0 ALIX V-shaped domain binding to HIV efThoc1 PF11957.8 EMC79415.1 - 9.7e-147 489.6 8.9 1.5e-146 488.9 8.9 1.3 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Death PF00531.22 EMC79415.1 - 3.4e-18 65.6 1.9 1.5e-17 63.5 0.5 2.6 2 0 0 2 2 2 1 Death domain CTD_bind PF04818.13 EMC79415.1 - 0.49 11.3 2.5 35 5.3 0.0 4.2 4 0 0 4 4 4 0 RNA polymerase II-binding domain. JmjN PF02375.17 EMC79415.1 - 5.3 7.1 4.8 3.2 7.8 0.1 2.7 2 0 0 2 2 2 0 jmjN domain UCH PF00443.29 EMC79416.1 - 1.4e-49 169.0 0.5 1.6e-49 168.7 0.5 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMC79416.1 - 9.6e-13 48.4 3.7 3.1e-12 46.8 3.7 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EMC79416.1 - 0.0006 19.5 0.0 0.0013 18.5 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Peptidase_C98 PF15499.6 EMC79416.1 - 0.00075 19.1 1.4 0.019 14.4 0.1 2.2 2 0 0 2 2 2 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase PFEMP PF03011.15 EMC79416.1 - 2.2 8.9 7.0 4.6 7.9 0.1 2.8 3 0 0 3 3 3 0 PFEMP DBL domain Pkinase PF00069.25 EMC79417.1 - 1.7e-62 211.2 0.0 1.7e-62 211.2 0.0 3.4 4 1 1 5 5 5 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC79417.1 - 4.1e-30 104.9 0.0 4.1e-30 104.9 0.0 2.3 3 0 0 3 3 3 1 Protein tyrosine kinase Rho_Binding PF08912.11 EMC79417.1 - 2.6e-23 82.6 14.5 2.6e-23 82.6 14.5 13.2 4 3 8 12 12 12 1 Rho Binding PH PF00169.29 EMC79417.1 - 3.9e-06 27.3 4.0 7.6e-05 23.2 0.1 3.3 3 0 0 3 3 3 1 PH domain C1_1 PF00130.22 EMC79417.1 - 0.00041 20.2 5.9 0.00084 19.2 5.9 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) APH PF01636.23 EMC79417.1 - 0.001 19.1 0.3 0.03 14.3 0.2 2.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_C PF00433.24 EMC79417.1 - 0.0071 17.0 3.1 0.01 16.5 1.3 2.4 2 0 0 2 2 2 1 Protein kinase C terminal domain DUF1192 PF06698.11 EMC79417.1 - 0.027 14.5 0.6 0.027 14.5 0.6 4.4 4 0 0 4 4 4 0 Protein of unknown function (DUF1192) LRR_8 PF13855.6 EMC79418.1 - 2e-55 184.4 60.8 6.2e-15 54.7 3.0 6.8 2 2 6 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 EMC79418.1 - 2.9e-23 81.5 30.0 4.2e-06 27.0 2.1 7.7 6 1 1 7 7 7 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC79418.1 - 3.3e-20 72.3 0.0 8.7e-09 35.4 0.0 2.5 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC79418.1 - 7.9e-09 35.3 13.8 0.00093 18.7 0.1 4.1 2 2 2 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 EMC79418.1 - 3.6e-06 26.8 28.8 0.2 12.3 0.0 11.1 9 3 0 9 9 9 2 Leucine Rich Repeat LRRNT PF01462.18 EMC79418.1 - 0.0024 17.5 1.2 0.0024 17.5 1.2 2.5 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain SWIM PF04434.17 EMC79418.1 - 0.63 9.8 5.3 6.8 6.5 0.1 3.1 3 0 0 3 3 3 0 SWIM zinc finger COesterase PF00135.28 EMC79419.1 - 8.8e-177 589.0 0.0 1e-176 588.8 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family AChE_tetra PF08674.10 EMC79419.1 - 4.6e-23 80.6 7.9 9.9e-23 79.6 7.9 1.6 1 0 0 1 1 1 1 Acetylcholinesterase tetramerisation domain Abhydrolase_3 PF07859.13 EMC79419.1 - 2.2e-07 31.0 0.2 4.5e-07 29.9 0.2 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold RRM_1 PF00076.22 EMC79420.1 - 1.9e-11 43.6 0.2 0.00019 21.2 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EMC79420.1 - 4.7e-07 29.7 0.0 0.00046 20.1 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif PWI PF01480.17 EMC79420.1 - 0.00017 21.9 0.2 0.00035 20.8 0.2 1.6 1 0 0 1 1 1 1 PWI domain zf-CCCH PF00642.24 EMC79420.1 - 0.00088 19.1 2.7 0.0017 18.2 2.7 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EMC79420.1 - 0.0054 16.7 1.6 0.01 15.9 1.6 1.5 1 0 0 1 1 1 1 Zinc finger domain Nup35_RRM PF05172.13 EMC79420.1 - 0.17 11.9 0.1 36 4.4 0.0 3.0 2 1 0 2 2 2 0 Nup53/35/40-type RNA recognition motif ApoO PF09769.9 EMC79422.1 - 9.8e-29 99.9 0.1 1.3e-28 99.5 0.1 1.2 1 0 0 1 1 1 1 Apolipoprotein O DUF2214 PF09980.9 EMC79422.1 - 0.088 12.6 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2214) C2 PF00168.30 EMC79423.1 - 2.6e-43 146.5 0.1 3.4e-20 72.2 0.0 3.0 3 0 0 3 3 3 2 C2 domain FYVE_2 PF02318.16 EMC79423.1 - 3.8e-08 33.6 6.6 8.5e-08 32.4 6.6 1.6 1 0 0 1 1 1 1 FYVE-type zinc finger Prok-RING_4 PF14447.6 EMC79423.1 - 0.046 13.6 5.7 0.094 12.6 5.7 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 EMC79423.1 - 0.74 10.0 6.8 1.7 8.8 6.8 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-MIZ PF02891.20 EMC79423.1 - 1.2 8.9 6.9 2.3 8.1 6.9 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-C3HC4_3 PF13920.6 EMC79423.1 - 1.3 9.0 7.4 2.7 7.9 7.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Tetraspanin PF00335.20 EMC79424.1 - 7.3e-30 104.4 4.8 8.1e-30 104.2 4.8 1.0 1 0 0 1 1 1 1 Tetraspanin family FixQ PF05545.11 EMC79424.1 - 0.0026 17.7 0.3 0.0046 16.9 0.3 1.4 1 0 0 1 1 1 1 Cbb3-type cytochrome oxidase component FixQ DUF4190 PF13828.6 EMC79424.1 - 0.073 12.8 3.8 0.56 10.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4190) FeoB_C PF07664.12 EMC79424.1 - 0.68 9.7 4.1 0.41 10.4 0.3 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B C terminus BRICHOS PF04089.14 EMC79425.1 - 4.6e-16 58.8 0.0 9.6e-16 57.8 0.0 1.5 1 0 0 1 1 1 1 BRICHOS domain RVT_1 PF00078.27 EMC79426.1 - 0.001 18.6 0.0 0.0016 18.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CNH PF00780.22 EMC79427.1 - 3.2e-68 230.3 0.2 5.7e-68 229.5 0.2 1.4 1 0 0 1 1 1 1 CNH domain Rap_GAP PF02145.15 EMC79427.1 - 3.9e-67 225.4 0.1 8e-67 224.4 0.1 1.6 1 0 0 1 1 1 1 Rap/ran-GAP HEPN_STY4199 PF18729.1 EMC79427.1 - 0.049 12.8 0.2 2.3 7.3 0.1 2.2 2 0 0 2 2 2 0 STY4199-like HEPN Sugar_tr PF00083.24 EMC79429.1 - 5e-99 332.2 21.1 6.1e-99 331.9 21.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMC79429.1 - 2.3e-31 109.0 26.9 2.3e-31 109.0 26.9 2.2 1 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EMC79429.1 - 9.4e-06 24.3 3.1 1.7e-05 23.5 3.1 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) WD40 PF00400.32 EMC79430.1 - 4.7e-16 58.9 11.3 1.4e-05 25.7 0.1 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat F-box-like PF12937.7 EMC79430.1 - 5.1e-08 32.7 4.7 1.7e-07 31.0 3.2 2.4 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EMC79430.1 - 1.9e-05 24.4 1.3 7.5e-05 22.5 0.6 2.3 1 1 1 2 2 2 1 F-box domain ANAPC4_WD40 PF12894.7 EMC79430.1 - 0.002 18.4 1.1 5.1 7.5 0.0 4.4 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Glyco_transf_92 PF01697.27 EMC79431.1 - 1.5e-42 146.1 1.1 2e-42 145.7 1.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 EMC79431.1 - 0.0075 16.8 0.0 0.017 15.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 DUF5122 PF17164.4 EMC79431.1 - 0.18 12.1 0.2 2.7 8.3 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5122) beta-propeller RasGEF PF00617.19 EMC79432.1 - 1.4e-50 172.0 3.9 5.2e-50 170.1 1.3 2.1 1 1 1 2 2 2 1 RasGEF domain PH PF00169.29 EMC79432.1 - 1.2e-10 41.9 0.0 2.8e-10 40.6 0.0 1.7 1 0 0 1 1 1 1 PH domain Fibrinogen_C PF00147.18 EMC79433.1 - 2.6e-74 249.7 12.1 3.6e-74 249.3 12.1 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fer4_NifH PF00142.18 EMC79433.1 - 0.027 13.9 1.0 0.078 12.4 1.2 1.6 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family DUF16 PF01519.16 EMC79433.1 - 1.2 9.7 11.4 0.72 10.4 4.1 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 BTB PF00651.31 EMC79434.1 - 7e-26 90.6 0.2 1.1e-25 89.9 0.2 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 EMC79434.1 - 9.4e-16 57.4 15.1 2.3e-07 31.0 0.6 4.6 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 EMC79434.1 - 4e-15 55.3 22.4 4.1e-05 23.8 2.1 4.1 4 0 0 4 4 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC79434.1 - 9.8e-13 47.8 14.8 0.0004 21.0 0.3 4.2 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 EMC79434.1 - 1.7e-08 34.5 7.2 0.0047 17.3 0.2 3.9 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMC79434.1 - 9.4e-06 25.8 6.3 0.29 11.5 0.0 3.8 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding DUF3342 PF11822.8 EMC79434.1 - 1.4e-05 25.2 0.1 3e-05 24.1 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) zf-C2H2_11 PF16622.5 EMC79434.1 - 2.6e-05 23.9 14.2 0.0058 16.4 0.2 4.1 4 0 0 4 4 4 2 zinc-finger C2H2-type zf-BED PF02892.15 EMC79434.1 - 0.00065 19.7 15.2 0.38 10.8 0.7 3.7 1 1 2 3 3 3 2 BED zinc finger zf-C2H2_2 PF12756.7 EMC79434.1 - 0.0031 17.8 9.2 0.15 12.4 0.1 3.9 2 1 2 4 4 4 1 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 EMC79434.1 - 0.015 15.3 10.7 0.56 10.3 0.5 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger DUF4187 PF13821.6 EMC79434.1 - 0.015 15.1 2.0 1.8 8.4 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4187) zf-H2C2_5 PF13909.6 EMC79434.1 - 0.046 13.5 5.6 1.3 8.8 0.1 3.7 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Chordopox_A33R PF05966.12 EMC79434.1 - 0.05 12.9 0.1 0.099 11.9 0.1 1.4 1 0 0 1 1 1 0 Chordopoxvirus A33R protein PyrI_C PF02748.15 EMC79434.1 - 0.45 10.5 7.5 6.1 6.8 0.1 3.5 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DUF4764 PF15961.5 EMC79434.1 - 0.64 8.6 12.1 4.6 5.8 0.1 3.1 2 1 0 3 3 3 0 Domain of unknown function (DUF4764) FYDLN_acid PF09538.10 EMC79434.1 - 0.72 10.6 3.9 20 5.9 0.1 3.5 2 1 2 4 4 3 0 Protein of unknown function (FYDLN_acid) zf-C2H2_3rep PF18868.1 EMC79434.1 - 0.96 10.1 8.0 22 5.8 0.6 3.5 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-Di19 PF05605.12 EMC79434.1 - 1.4 9.3 9.9 0.54 10.6 3.1 3.0 2 1 1 3 3 2 0 Drought induced 19 protein (Di19), zinc-binding zf_C2H2_ZHX PF18387.1 EMC79434.1 - 1.9 8.2 4.6 16 5.2 0.1 3.1 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain HNH_5 PF14279.6 EMC79434.1 - 2.2 8.2 7.1 6.2 6.8 0.1 3.3 3 0 0 3 3 3 0 HNH endonuclease zf-C2HE PF16278.5 EMC79434.1 - 2.5 8.6 9.5 2.6 8.6 0.1 3.4 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2HC_2 PF13913.6 EMC79434.1 - 4 7.5 12.0 3.7 7.6 0.1 3.6 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf_UBZ PF18439.1 EMC79434.1 - 4.1 7.1 5.6 4.5 6.9 0.3 3.0 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-trcl PF13451.6 EMC79434.1 - 8.8 6.3 7.7 8.3 6.4 4.4 2.3 2 0 0 2 2 2 0 Probable zinc-ribbon domain BTB PF00651.31 EMC79435.1 - 3.6e-29 101.2 0.2 1.6e-19 70.1 0.0 2.4 1 1 1 2 2 2 2 BTB/POZ domain zf-H2C2_2 PF13465.6 EMC79435.1 - 3.4e-09 36.7 16.1 1.8e-06 28.1 0.5 4.2 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 EMC79435.1 - 7.9e-08 32.4 20.8 0.0016 18.8 2.5 4.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC79435.1 - 0.00011 22.7 21.4 0.032 15.1 1.8 4.5 3 0 0 3 3 3 3 C2H2-type zinc finger Zn_ribbon_SprT PF17283.2 EMC79435.1 - 0.0033 17.3 2.9 0.0033 17.3 2.9 2.1 2 0 0 2 2 2 1 SprT-like zinc ribbon domain zf-C2H2_8 PF15909.5 EMC79435.1 - 0.099 13.0 6.2 0.84 10.0 4.8 2.8 2 0 0 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 EMC79435.1 - 0.14 12.2 13.8 0.74 9.9 0.1 4.2 3 0 0 3 3 3 0 C2H2-type zinc finger zf-met PF12874.7 EMC79435.1 - 0.15 12.5 10.8 12 6.5 0.7 4.0 3 0 0 3 3 3 0 Zinc-finger of C2H2 type DUF2256 PF10013.9 EMC79435.1 - 2.6 8.2 7.6 1.7 8.8 0.7 3.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) Zn-ribbon_8 PF09723.10 EMC79435.1 - 3.4 7.9 6.5 9 6.5 0.3 3.2 2 1 1 3 3 3 0 Zinc ribbon domain Zn_Tnp_IS91 PF14319.6 EMC79435.1 - 3.9 7.6 8.0 0.37 10.8 1.5 2.6 1 1 1 2 2 2 0 Transposase zinc-binding domain OGFr_III PF04680.13 EMC79436.1 - 0.00032 21.2 170.8 6.7 7.5 3.9 15.1 15 0 0 15 15 15 15 Opioid growth factor receptor repeat Homeodomain PF00046.29 EMC79437.1 - 2.5e-18 65.7 2.5 5.9e-18 64.5 2.5 1.7 1 0 0 1 1 1 1 Homeodomain LIM PF00412.22 EMC79437.1 - 3.9e-17 62.2 11.3 6.4e-17 61.5 11.3 1.4 1 0 0 1 1 1 1 LIM domain Homeobox_KN PF05920.11 EMC79437.1 - 8.1e-05 22.4 0.0 0.00019 21.2 0.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain PBC PF03792.13 EMC79438.1 - 1e-64 217.8 6.9 3.8e-63 212.7 4.0 2.5 2 1 0 2 2 2 1 PBC domain Homeodomain PF00046.29 EMC79438.1 - 2.7e-19 68.8 1.2 5.6e-19 67.7 1.2 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC79438.1 - 2.3e-15 56.2 0.0 5.3e-15 55.0 0.0 1.7 1 0 0 1 1 1 1 Homeobox KN domain YdaS_antitoxin PF15943.5 EMC79438.1 - 0.02 14.8 0.0 0.043 13.7 0.0 1.5 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Sec15 PF04091.12 EMC79438.1 - 0.03 13.7 0.1 0.047 13.1 0.1 1.3 1 0 0 1 1 1 0 Exocyst complex subunit Sec15-like LZ3wCH PF18517.1 EMC79438.1 - 0.049 13.7 0.2 0.17 12.0 0.0 2.1 2 0 0 2 2 2 0 Leucine zipper with capping helix domain Auxin_canalis PF05703.11 EMC79438.1 - 0.12 12.2 5.9 0.32 10.9 5.9 1.6 1 1 0 1 1 1 0 Auxin canalisation CRIM PF16978.5 EMC79439.1 - 4.3e-36 124.1 0.0 1.1e-35 122.8 0.0 1.6 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1 PF05422.12 EMC79439.1 - 4.9e-33 114.7 11.6 4.7e-30 105.0 7.8 3.5 2 1 0 2 2 2 2 Stress-activated map kinase interacting protein 1 (SIN1) SIN1_PH PF16979.5 EMC79439.1 - 3.6e-28 98.0 0.3 6.8e-28 97.1 0.3 1.5 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology Plasmodium_HRP PF05403.11 EMC79440.1 - 1.3e-07 31.6 32.8 0.0059 16.4 7.9 3.0 1 1 2 3 3 3 3 Plasmodium histidine-rich protein (HRPII/III) Collagen PF01391.18 EMC79440.1 - 0.0024 17.6 41.7 1.5 8.6 7.5 4.2 1 1 3 4 4 4 2 Collagen triple helix repeat (20 copies) Extensin_2 PF04554.13 EMC79440.1 - 1.5 9.0 78.4 1.8e+04 -52.2 78.4 5.2 1 1 0 1 1 1 0 Extensin-like region RasGAP PF00616.19 EMC79441.1 - 2.9e-31 108.8 0.0 1e-30 107.1 0.0 2.0 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase VPS9 PF02204.18 EMC79441.1 - 1.3e-28 99.3 0.0 3.9e-28 97.7 0.0 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EMC79441.1 - 3.4e-12 46.5 0.2 1.1e-11 44.8 0.2 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) SURF2 PF05477.11 EMC79441.1 - 0.51 10.0 5.9 2.5 7.7 0.1 2.4 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) HSP70 PF00012.20 EMC79442.1 - 3.1e-258 857.9 10.2 3.5e-258 857.7 10.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EMC79442.1 - 3.5e-17 62.2 0.1 7.6e-17 61.1 0.1 1.5 1 1 0 1 1 1 1 MreB/Mbl protein Hydantoinase_A PF01968.18 EMC79442.1 - 0.0036 16.6 0.2 0.013 14.8 0.1 1.9 1 1 0 1 1 1 1 Hydantoinase/oxoprolinase DDR PF08841.10 EMC79442.1 - 0.008 15.2 1.0 0.021 13.8 0.6 1.8 1 1 0 1 1 1 1 Diol dehydratase reactivase ATPase-like domain FGGY_C PF02782.16 EMC79442.1 - 0.036 13.8 0.0 0.068 12.9 0.0 1.4 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Radial_spoke_3 PF06098.11 EMC79442.1 - 1.6 8.0 13.1 0.038 13.3 5.9 1.8 2 0 0 2 2 2 0 Radial spoke protein 3 Kelch_3 PF13415.6 EMC79443.1 - 3e-26 91.1 6.8 4.1e-07 30.1 0.0 4.9 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_1 PF01344.25 EMC79443.1 - 3.7e-23 80.8 0.5 6.8e-07 28.8 0.0 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 EMC79443.1 - 8.3e-21 73.7 7.2 1.2e-06 28.4 0.0 4.7 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.6 EMC79443.1 - 1.4e-19 69.6 1.4 6.9e-06 26.2 0.0 4.0 2 1 2 4 4 4 3 Kelch motif Kelch_5 PF13854.6 EMC79443.1 - 1.6e-19 69.5 6.8 5.8e-06 26.2 0.1 4.9 4 1 0 4 4 4 4 Kelch motif Kelch_2 PF07646.15 EMC79443.1 - 1.1e-13 50.5 3.8 4.3e-05 23.3 0.0 4.3 4 1 0 4 4 4 3 Kelch motif PQQ_3 PF13570.6 EMC79443.1 - 0.26 11.8 5.6 1.9 9.1 0.0 3.7 2 1 2 4 4 4 0 PQQ-like domain P16-Arc PF04699.14 EMC79444.1 - 6.8e-35 120.7 0.0 7.3e-35 120.6 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Utp12 PF04003.12 EMC79444.1 - 0.018 15.4 0.0 0.02 15.2 0.0 1.2 1 0 0 1 1 1 0 Dip2/Utp12 Family Ribosomal_L29 PF00831.23 EMC79445.1 - 5.4e-20 71.1 2.1 5.4e-20 71.1 2.1 2.4 2 1 1 3 3 3 1 Ribosomal L29 protein XFP_N PF09364.10 EMC79445.1 - 0.1 11.3 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 XFP N-terminal domain OLF PF02191.16 EMC79446.1 - 2.1e-48 165.1 3.4 2.1e-48 165.1 3.4 1.4 2 0 0 2 2 2 1 Olfactomedin-like domain Dehalogenase PF13486.6 EMC79446.1 - 0.022 14.1 0.0 0.04 13.3 0.0 1.3 1 0 0 1 1 1 0 Reductive dehalogenase subunit zf-C4 PF00105.18 EMC79447.1 - 4.3e-28 97.6 17.9 8.3e-28 96.7 17.9 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 EMC79447.1 - 3.8e-17 62.5 5.8 4.7e-16 59.0 5.8 2.2 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor 7tm_2 PF00002.24 EMC79448.1 - 1.7e-48 165.1 24.6 2.6e-48 164.5 24.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Pentaxin PF00354.17 EMC79448.1 - 1.4e-27 96.7 0.1 2.7e-27 95.7 0.1 1.5 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.6 EMC79448.1 - 6.5e-13 49.1 0.1 1.1e-12 48.3 0.1 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily GPS PF01825.21 EMC79448.1 - 5.2e-10 39.7 2.4 5.2e-10 39.7 2.4 3.0 3 0 0 3 3 3 1 GPCR proteolysis site, GPS, motif GAIN PF16489.5 EMC79448.1 - 1e-05 25.1 0.1 2.2e-05 24.0 0.1 1.6 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Tex_N PF09371.10 EMC79448.1 - 2.2e-05 24.2 0.2 5.4e-05 22.9 0.0 1.7 2 0 0 2 2 2 1 Tex-like protein N-terminal domain Dicty_CAR PF05462.11 EMC79448.1 - 7.9e-05 21.9 10.1 0.00014 21.1 10.1 1.5 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Lectin_C PF00059.21 EMC79448.1 - 0.33 11.7 1.7 3.4 8.4 0.0 3.1 4 0 0 4 4 4 0 Lectin C-type domain Pox_P21 PF05313.12 EMC79448.1 - 7.4 6.1 12.2 0.36 10.4 2.3 2.4 2 0 0 2 2 2 0 Poxvirus P21 membrane protein Proteasome PF00227.26 EMC79449.1 - 2.8e-46 157.4 0.0 4e-46 156.9 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 EMC79449.1 - 1.8e-14 52.9 0.2 3.3e-14 52.0 0.2 1.5 1 0 0 1 1 1 1 Proteasome beta subunits C terminal Pkinase PF00069.25 EMC79450.1 - 1.7e-64 217.8 0.0 2.1e-64 217.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC79450.1 - 2.1e-46 158.3 0.0 2.5e-46 158.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EMC79450.1 - 2.4e-05 23.5 0.2 5e-05 22.4 0.2 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EMC79450.1 - 0.0011 17.9 0.0 0.0014 17.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EMC79450.1 - 0.002 17.5 0.0 0.003 16.9 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC79450.1 - 0.0027 17.1 0.0 0.0047 16.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RecG_N PF17190.4 EMC79450.1 - 0.045 14.5 0.3 0.25 12.1 0.2 2.2 3 0 0 3 3 3 0 RecG N-terminal helical domain PIP49_C PF12260.8 EMC79450.1 - 0.077 12.6 0.2 4.1 7.0 0.1 2.2 2 0 0 2 2 2 0 Protein-kinase domain of FAM69 Gln_deamidase_2 PF18626.1 EMC79450.1 - 0.1 12.9 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 Glutaminase LIM PF00412.22 EMC79451.1 - 5.3e-31 106.6 21.1 2.8e-15 56.3 3.8 2.3 2 0 0 2 2 2 2 LIM domain Homeodomain PF00046.29 EMC79451.1 - 6.5e-19 67.5 3.7 1.2e-18 66.6 3.7 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC79451.1 - 3.9e-05 23.4 1.5 0.00012 21.9 1.5 1.9 1 1 0 1 1 1 1 Homeobox KN domain DUF1314 PF07013.11 EMC79451.1 - 0.0012 18.8 0.1 0.0027 17.6 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1314) Homez PF11569.8 EMC79451.1 - 0.008 15.6 0.0 0.017 14.5 0.0 1.5 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez Yippee-Mis18 PF03226.14 EMC79451.1 - 5.5 7.3 11.6 1.2 9.3 1.6 2.5 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DENN PF02141.21 EMC79452.1 - 6.9e-47 159.8 2.6 1.4e-46 158.8 2.6 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 EMC79452.1 - 3e-11 43.9 1.0 3e-11 43.9 1.0 2.5 2 0 0 2 2 2 1 uDENN domain dDENN PF03455.19 EMC79452.1 - 1.9e-10 40.6 2.0 4e-10 39.5 2.0 1.6 1 0 0 1 1 1 1 dDENN domain DZF PF07528.14 EMC79453.1 - 7.7e-80 268.1 0.0 1.2e-79 267.4 0.0 1.3 1 0 0 1 1 1 1 DZF domain dsrm PF00035.26 EMC79453.1 - 4e-26 91.5 0.0 1.8e-13 51.0 0.0 2.7 2 0 0 2 2 2 2 Double-stranded RNA binding motif SGP PF17228.2 EMC79453.1 - 0.0015 19.3 2.1 0.0015 19.3 2.1 1.8 2 0 0 2 2 2 1 Sulphur globule protein DND1_DSRM PF14709.7 EMC79453.1 - 0.007 16.6 3.5 4.1 7.7 0.1 3.8 3 2 0 3 3 3 2 double strand RNA binding domain from DEAD END PROTEIN 1 BTB PF00651.31 EMC79454.1 - 3.9e-18 65.7 0.1 1.2e-17 64.1 0.1 1.9 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.26 EMC79454.1 - 5.6e-18 64.3 38.8 1.2e-05 25.5 2.6 5.2 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC79454.1 - 6.1e-17 61.2 18.3 3.7e-07 30.3 0.7 5.7 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC79454.1 - 2.1e-12 46.7 36.8 0.00017 22.1 2.7 5.0 5 0 0 5 5 4 4 C2H2-type zinc finger zf-met PF12874.7 EMC79454.1 - 0.00026 21.2 22.6 0.015 15.6 1.8 4.6 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 EMC79454.1 - 0.00037 20.2 23.9 0.0053 16.5 2.3 4.3 4 0 0 4 4 4 3 zinc-finger C2H2-type zf-H2C2_5 PF13909.6 EMC79454.1 - 0.00082 19.1 23.7 0.0029 17.3 2.4 4.4 5 0 0 5 5 5 2 C2H2-type zinc-finger domain DUF899 PF05988.12 EMC79454.1 - 0.00099 18.7 0.1 0.00099 18.7 0.1 1.9 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF899) zf-C2H2_2 PF12756.7 EMC79454.1 - 0.061 13.7 28.4 0.35 11.2 0.8 5.3 2 1 4 6 6 5 0 C2H2 type zinc-finger (2 copies) zf-CHCC PF10276.9 EMC79454.1 - 0.13 12.4 4.2 0.15 12.1 0.1 2.7 3 0 0 3 3 2 0 Zinc-finger domain zf-C2H2_jaz PF12171.8 EMC79454.1 - 0.14 12.5 19.2 2.3 8.6 0.1 4.6 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 EMC79454.1 - 0.39 10.6 3.4 9.2 6.3 0.0 3.3 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain GAGA PF09237.11 EMC79454.1 - 0.44 10.4 8.3 27 4.7 0.1 4.2 1 1 3 4 4 4 0 GAGA factor AHH PF14412.6 EMC79454.1 - 0.58 10.2 7.3 92 3.1 7.3 2.8 1 1 0 1 1 1 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH zf-C2H2_6 PF13912.6 EMC79454.1 - 1.6 8.8 29.4 1.2 9.2 2.5 4.6 4 0 0 4 4 4 0 C2H2-type zinc finger zf-Dof PF02701.15 EMC79454.1 - 2.2 8.5 8.0 0.094 12.9 0.8 2.4 1 1 1 2 2 2 0 Dof domain, zinc finger Zn-ribbon_8 PF09723.10 EMC79454.1 - 3.8 7.7 9.0 29 4.9 2.3 3.8 2 1 0 3 3 3 0 Zinc ribbon domain FYVE PF01363.21 EMC79454.1 - 4.6 7.5 22.0 19 5.5 13.6 3.5 1 1 1 2 2 2 0 FYVE zinc finger Sprouty PF05210.13 EMC79454.1 - 5.7 7.4 8.9 4.6 7.7 3.8 2.9 1 1 1 2 2 2 0 Sprouty protein (Spry) Phosducin PF02114.16 EMC79455.1 - 4e-135 448.9 3.3 5e-135 448.6 3.3 1.1 1 0 0 1 1 1 1 Phosducin MRC1 PF09444.10 EMC79455.1 - 0.66 10.5 19.3 0.038 14.5 12.4 2.3 2 1 0 2 2 2 0 MRC1-like domain FtsX_ECD PF18075.1 EMC79455.1 - 2.2 9.0 6.9 0.26 11.9 2.3 1.9 2 0 0 2 2 2 0 FtsX extracellular domain An_peroxidase PF03098.15 EMC79456.1 - 2.8e-45 154.9 0.0 3.1e-28 98.7 0.0 3.1 2 1 1 3 3 3 3 Animal haem peroxidase EGF PF00008.27 EMC79456.1 - 6e-06 26.5 8.1 1.4e-05 25.3 8.1 1.6 1 0 0 1 1 1 1 EGF-like domain EGF_2 PF07974.13 EMC79456.1 - 0.068 13.5 10.3 0.13 12.6 10.3 1.4 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 EMC79456.1 - 0.12 13.1 4.1 0.28 11.9 4.1 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF RRF PF01765.19 EMC79457.1 - 1.1e-43 149.1 4.3 1.6e-43 148.5 4.3 1.3 1 0 0 1 1 1 1 Ribosome recycling factor DUF2072 PF09845.9 EMC79457.1 - 0.0095 16.2 0.4 0.076 13.3 0.0 2.1 2 0 0 2 2 2 1 Zn-ribbon containing protein DUF951 PF06107.11 EMC79457.1 - 0.075 12.9 0.1 0.19 11.7 0.1 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF951) Thiamine_BP PF01910.17 EMC79457.1 - 0.083 12.8 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 Thiamine-binding protein Robl_LC7 PF03259.17 EMC79457.1 - 0.096 12.5 0.0 12 5.7 0.0 2.6 2 0 0 2 2 2 0 Roadblock/LC7 domain YvbH_ext PF11724.8 EMC79457.1 - 0.12 12.7 0.6 0.23 11.8 0.6 1.5 1 0 0 1 1 1 0 YvbH-like oligomerisation region DUF3810 PF12725.7 EMC79457.1 - 0.74 9.1 4.4 0.48 9.7 2.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) DUF883 PF05957.13 EMC79457.1 - 0.75 10.4 7.5 0.25 12.0 3.1 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) YtxH PF12732.7 EMC79457.1 - 0.81 10.3 10.0 1.1 9.9 6.2 2.5 2 1 0 2 2 2 0 YtxH-like protein RRM_1 PF00076.22 EMC79458.1 - 5.3e-12 45.4 0.1 8.5e-12 44.7 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SET_assoc PF11767.8 EMC79458.1 - 0.12 12.0 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated Homeodomain PF00046.29 EMC79459.1 - 2e-20 72.3 2.0 3.6e-20 71.5 2.0 1.4 1 0 0 1 1 1 1 Homeodomain LIM PF00412.22 EMC79459.1 - 1.3e-16 60.6 11.8 7.1e-11 42.2 3.0 3.3 2 1 0 2 2 2 2 LIM domain Homeobox_KN PF05920.11 EMC79459.1 - 0.00016 21.5 1.2 0.00027 20.8 0.2 1.9 2 0 0 2 2 2 1 Homeobox KN domain DZR PF12773.7 EMC79459.1 - 0.056 13.5 1.3 0.056 13.5 1.3 2.8 2 0 0 2 2 2 0 Double zinc ribbon BON PF04972.17 EMC79459.1 - 0.07 13.5 0.0 1.1 9.6 0.0 2.2 2 0 0 2 2 2 0 BON domain DUF2175 PF09943.9 EMC79459.1 - 0.16 12.3 0.2 0.16 12.3 0.2 2.8 2 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) Sgf11 PF08209.11 EMC79459.1 - 6.5 6.4 12.2 0.7 9.5 2.2 3.1 2 1 1 3 3 3 0 Sgf11 (transcriptional regulation protein) MORN PF02493.20 EMC79460.1 - 3.1e-10 39.3 8.8 1.6e-05 24.5 0.2 4.7 5 0 0 5 5 5 3 MORN repeat CHCH PF06747.13 EMC79461.1 - 1.3e-08 34.7 1.4 1.7e-08 34.4 1.4 1.2 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 EMC79461.1 - 0.036 14.1 1.9 0.11 12.5 2.0 1.7 1 1 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, COX6B PF02297.17 EMC79461.1 - 0.059 13.6 1.8 0.077 13.2 1.8 1.2 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb Cmc1 PF08583.10 EMC79461.1 - 0.061 13.4 0.7 0.081 12.9 0.7 1.1 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like TTL PF03133.15 EMC79463.1 - 9.1e-19 67.7 0.0 1.6e-18 66.9 0.0 1.5 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_ST PF14397.6 EMC79463.1 - 4.2e-05 22.9 0.0 9.1e-05 21.8 0.0 1.5 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp ATPgrasp_YheCD PF14398.6 EMC79463.1 - 0.0058 15.9 0.0 0.0082 15.4 0.0 1.3 1 0 0 1 1 1 1 YheC/D like ATP-grasp YajC PF02699.15 EMC79464.1 - 0.066 13.1 0.0 0.089 12.7 0.0 1.3 1 0 0 1 1 1 0 Preprotein translocase subunit Ribosomal_L5 PF00281.19 EMC79466.1 - 6.8e-23 80.8 0.0 5e-21 74.8 0.0 2.2 2 0 0 2 2 2 2 Ribosomal protein L5 Ribosomal_L5_C PF00673.21 EMC79466.1 - 2.8e-21 75.5 0.0 4.4e-21 74.9 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Palm_thioest PF02089.15 EMC79467.1 - 3.8e-75 252.8 0.0 4.3e-75 252.7 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase AlkA_N PF06029.11 EMC79467.1 - 0.17 12.1 0.0 0.31 11.3 0.0 1.3 1 0 0 1 1 1 0 AlkA N-terminal domain CAP_N PF01213.19 EMC79468.1 - 2.8e-111 372.0 0.2 5.9e-111 370.9 0.2 1.5 1 1 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 EMC79468.1 - 2.7e-65 218.8 3.2 3.8e-65 218.3 3.2 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 EMC79468.1 - 0.00017 21.3 1.6 0.00041 20.1 1.6 1.6 1 1 0 1 1 1 1 Tubulin binding cofactor C WH2 PF02205.20 EMC79468.1 - 0.081 12.8 0.1 0.21 11.5 0.1 1.7 1 0 0 1 1 1 0 WH2 motif MFS_2 PF13347.6 EMC79469.1 - 5.7e-125 417.2 23.7 6.4e-125 417.1 23.7 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1 PF07690.16 EMC79469.1 - 5.3e-14 51.9 20.7 4.4e-13 48.9 19.7 2.1 1 1 0 2 2 2 1 Major Facilitator Superfamily EF-hand_1 PF00036.32 EMC79470.1 - 7.3e-17 59.6 5.6 4.1e-07 29.1 0.1 3.9 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 EMC79470.1 - 5.7e-16 57.0 2.5 1.1e-06 28.0 0.1 3.9 3 1 1 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 EMC79470.1 - 1.9e-15 57.1 1.7 7.7e-05 23.1 0.1 3.1 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EMC79470.1 - 3.3e-13 48.5 4.9 4.4e-05 22.8 0.1 3.6 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 EMC79470.1 - 6.2e-06 26.0 6.1 0.002 17.9 0.5 3.6 2 1 1 3 3 3 2 EF-hand domain pair Dockerin_1 PF00404.18 EMC79470.1 - 0.00088 19.4 0.0 0.036 14.2 0.0 2.1 2 0 0 2 2 2 1 Dockerin type I domain EF-hand_4 PF12763.7 EMC79470.1 - 0.0082 16.1 1.1 3.2 7.7 0.0 3.0 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EMC79470.1 - 0.012 15.9 0.7 5 7.5 0.0 2.4 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region ApoM PF11032.8 EMC79470.1 - 0.046 13.4 0.1 0.15 11.7 0.1 1.7 1 1 0 1 1 1 0 ApoM domain YxiJ PF14176.6 EMC79470.1 - 0.081 13.4 0.1 0.13 12.8 0.1 1.4 1 0 0 1 1 1 0 YxiJ-like protein 5-nucleotidase PF06189.12 EMC79471.1 - 7.1e-106 353.0 0.0 3e-105 350.9 0.0 1.7 1 1 1 2 2 2 1 5'-nucleotidase RRM_1 PF00076.22 EMC79472.1 - 3.1e-92 302.4 2.4 3.2e-24 84.5 0.3 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EMC79472.1 - 2.8e-32 110.7 0.2 1.5e-31 108.4 0.3 2.2 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 EMC79472.1 - 1e-09 38.0 0.2 0.014 15.0 0.1 4.2 1 1 3 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EMC79472.1 - 1.6e-07 31.3 1.4 0.61 10.2 0.0 4.4 4 0 0 4 4 4 2 Limkain b1 RRM_occluded PF16842.5 EMC79472.1 - 5.4e-07 29.4 0.0 0.074 12.9 0.0 4.0 4 0 0 4 4 4 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EMC79472.1 - 1.9e-06 27.8 0.1 9.1 6.4 0.0 4.4 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EMC79472.1 - 1.3e-05 25.2 1.6 3.2 7.9 0.1 5.3 3 3 1 4 4 4 2 RNA recognition motif SET_assoc PF11767.8 EMC79472.1 - 5.3e-05 22.8 0.2 7.9 6.2 0.0 4.3 4 0 0 4 4 4 1 Histone lysine methyltransferase SET associated RRM_3 PF08777.11 EMC79472.1 - 8.4e-05 22.6 6.3 0.13 12.3 0.8 3.9 4 0 0 4 4 4 2 RNA binding motif OB_RNB PF08206.11 EMC79472.1 - 0.008 15.8 3.2 2.1 8.1 0.1 3.4 3 0 0 3 3 3 1 Ribonuclease B OB domain PHM7_cyt PF14703.6 EMC79472.1 - 0.093 13.0 2.0 49 4.1 0.0 4.8 3 1 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter DbpA PF03880.15 EMC79472.1 - 0.12 12.4 0.1 40 4.3 0.0 3.3 3 0 0 3 3 3 0 DbpA RNA binding domain NOP5NT PF08156.13 EMC79472.1 - 0.27 11.6 2.3 0.86 10.0 0.1 3.1 4 0 0 4 4 4 0 NOP5NT (NUC127) domain HHV-5_US34A PF17087.5 EMC79472.1 - 0.99 9.6 4.2 23 5.2 1.5 2.5 2 0 0 2 2 2 0 Herpesvirus US34A protein family Pro_isomerase PF00160.21 EMC79473.1 - 5.3e-47 160.0 0.2 7.8e-47 159.5 0.2 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 EMC79473.1 - 2.4e-19 68.9 0.0 4.6e-19 68.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMC79473.1 - 0.0078 15.8 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spectrin PF00435.21 EMC79474.1 - 4.2e-155 506.1 161.5 7.7e-18 64.9 4.4 18.1 18 0 0 18 18 18 17 Spectrin repeat GAS2 PF02187.17 EMC79474.1 - 1.9e-33 114.4 0.4 5.8e-33 112.8 0.4 2.0 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain EF-hand_1 PF00036.32 EMC79474.1 - 1.6e-12 46.0 2.2 3.7e-05 23.0 0.7 3.0 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EMC79474.1 - 1.7e-11 43.0 1.6 0.00016 21.3 0.4 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 EMC79474.1 - 8e-11 42.2 1.8 4.5e-10 39.8 0.9 2.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 EMC79474.1 - 2.2e-08 33.8 0.3 9.9e-08 31.7 0.1 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EMC79474.1 - 2.5e-08 33.0 4.5 1.9e-05 23.9 1.1 2.9 2 0 0 2 2 2 2 EF hand DUF1959 PF09218.10 EMC79474.1 - 0.01 15.9 2.0 0.68 10.1 0.1 3.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1959) Laminin_II PF06009.12 EMC79474.1 - 0.1 12.6 0.1 0.1 12.6 0.1 11.2 11 2 2 13 13 13 0 Laminin Domain II Prefoldin_2 PF01920.20 EMC79474.1 - 0.25 11.3 0.0 0.25 11.3 0.0 12.8 10 4 2 13 13 12 0 Prefoldin subunit FNIP_M PF14637.6 EMC79474.1 - 2.1 8.3 5.8 6.7 6.7 0.0 3.5 3 0 0 3 3 3 0 Folliculin-interacting protein middle domain Virulence_fact PF13769.6 EMC79474.1 - 5.1 7.4 9.1 0.99 9.7 0.2 4.6 5 0 0 5 5 5 0 Virulence factor FYRC PF05965.14 EMC79474.1 - 7.7 6.8 6.1 17 5.6 0.1 4.4 4 0 0 4 4 4 0 F/Y rich C-terminus zinc_ribbon_9 PF14369.6 EMC79475.1 - 0.0019 18.4 2.9 0.0054 17.0 0.2 2.9 2 0 0 2 2 2 1 zinc-ribbon Rad50_zn_hook PF04423.14 EMC79475.1 - 0.41 10.5 2.5 1.2 9.1 0.2 2.3 2 0 0 2 2 2 0 Rad50 zinc hook motif RNA_pol_Rpc82 PF05645.13 EMC79476.1 - 1.8e-30 106.6 0.8 2.5e-27 96.3 0.0 3.2 4 0 0 4 4 4 2 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 EMC79476.1 - 5.4e-23 80.9 3.8 4.6e-18 65.1 0.1 4.7 5 0 0 5 5 5 3 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 EMC79476.1 - 0.093 12.6 0.0 1.1 9.1 0.0 2.7 3 0 0 3 3 3 0 TFIIE alpha subunit NIT PF08376.10 EMC79476.1 - 0.12 12.9 0.6 0.21 12.0 0.6 1.4 1 0 0 1 1 1 0 Nitrate and nitrite sensing PRIMA1 PF16101.5 EMC79476.1 - 0.36 10.9 1.7 0.87 9.6 1.7 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Peptidase_C1 PF00112.23 EMC79477.1 - 8.9e-40 137.1 0.0 9.5e-40 137.0 0.0 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EMC79477.1 - 0.003 16.4 0.3 0.0038 16.1 0.3 1.1 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 EMC79478.1 - 3e-60 204.0 3.8 3.4e-45 154.8 0.4 2.1 1 1 1 2 2 2 2 Papain family cysteine protease Inhibitor_I29 PF08246.12 EMC79478.1 - 3.1e-12 46.8 0.1 4.8e-12 46.1 0.1 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EMC79478.1 - 3.6e-07 29.3 1.9 0.00032 19.6 0.3 2.1 2 0 0 2 2 2 2 Peptidase C1-like family DUF5604 PF18300.1 EMC79479.1 - 1.1e-17 63.7 1.8 2e-17 62.9 1.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5604) P4Ha_N PF08336.11 EMC79479.1 - 0.0025 17.8 5.4 1.9 8.5 4.1 2.4 2 1 0 2 2 2 2 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Prominin PF05478.11 EMC79479.1 - 0.064 11.2 0.6 0.92 7.4 0.3 2.0 2 0 0 2 2 2 0 Prominin Cupin_8 PF13621.6 EMC79479.1 - 0.075 12.7 0.4 0.1 12.3 0.4 1.2 1 0 0 1 1 1 0 Cupin-like domain zf-C4H2 PF10146.9 EMC79479.1 - 0.12 12.6 11.6 0.28 11.5 11.6 1.5 1 1 0 1 1 1 0 Zinc finger-containing protein HTH_26 PF13443.6 EMC79479.1 - 0.27 11.7 2.6 18 5.8 0.3 2.8 2 1 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain DUF1664 PF07889.12 EMC79479.1 - 0.31 11.1 5.9 3.9 7.5 3.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) TMF_DNA_bd PF12329.8 EMC79479.1 - 0.4 10.7 11.0 0.2 11.7 6.1 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF241 PF03087.14 EMC79479.1 - 0.42 10.4 9.5 3.6 7.3 7.7 2.2 2 0 0 2 2 2 0 Arabidopsis protein of unknown function HU-CCDC81_bac_2 PF18175.1 EMC79479.1 - 0.51 10.3 3.8 2.5 8.0 3.8 2.1 1 1 0 1 1 1 0 CCDC81-like prokaryotic HU domain 2 Fib_alpha PF08702.10 EMC79479.1 - 0.7 10.1 8.5 20 5.4 0.0 2.5 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family KxDL PF10241.9 EMC79479.1 - 1.7 9.0 8.2 2.2 8.6 2.8 2.6 2 1 0 2 2 2 0 Uncharacterized conserved protein DUF842 PF05811.13 EMC79479.1 - 5.2 6.8 12.1 1.3 8.7 1.8 2.7 2 1 1 3 3 3 0 Eukaryotic protein of unknown function (DUF842) DHHA2 PF02833.14 EMC79480.1 - 1.4e-22 80.4 0.0 9.1e-22 77.8 0.0 2.0 1 1 0 1 1 1 1 DHHA2 domain DHH PF01368.20 EMC79480.1 - 6.4e-06 26.3 0.0 6.6e-05 23.1 0.0 2.4 1 1 1 2 2 2 1 DHH family PBD PF00786.28 EMC79481.1 - 0.00012 22.3 0.0 0.00021 21.6 0.0 1.4 1 0 0 1 1 1 1 P21-Rho-binding domain S_100 PF01023.19 EMC79482.1 - 5.5e-11 42.0 0.0 1.3e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.32 EMC79482.1 - 1.1e-05 24.7 0.7 3.4e-05 23.1 0.1 1.9 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 EMC79482.1 - 0.00013 22.3 1.4 0.0003 21.2 1.4 1.6 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EMC79482.1 - 0.0002 21.0 0.6 0.00046 19.9 0.3 1.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_4 PF12763.7 EMC79482.1 - 0.0016 18.3 0.2 0.0021 18.0 0.2 1.1 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_8 PF13833.6 EMC79482.1 - 0.039 13.8 0.3 0.24 11.2 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain pair S_100 PF01023.19 EMC79483.1 - 8.5e-21 73.4 0.3 1.2e-20 72.9 0.3 1.2 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.32 EMC79483.1 - 0.00063 19.1 0.7 0.003 17.0 0.1 2.2 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 EMC79483.1 - 0.00095 19.6 0.4 0.0015 18.9 0.4 1.5 1 0 0 1 1 1 1 EF-hand domain pair DEK_C PF08766.11 EMC79483.1 - 0.0045 16.9 1.4 0.0085 16.0 1.4 1.4 1 0 0 1 1 1 1 DEK C terminal domain DUF5421 PF17458.2 EMC79483.1 - 0.18 11.1 3.9 0.19 11.1 3.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5421) Cornifin PF02389.15 EMC79485.1 - 0.0014 18.9 67.0 0.0014 18.9 67.0 2.1 1 1 1 2 2 2 2 Cornifin (SPRR) family Keratin PF02422.16 EMC79487.1 - 1.2e-31 108.2 9.0 1.4e-31 108.1 9.0 1.0 1 0 0 1 1 1 1 Keratin Cornifin PF02389.15 EMC79487.1 - 0.0024 18.1 4.8 0.0028 17.8 4.8 1.1 1 0 0 1 1 1 1 Cornifin (SPRR) family DUF3432 PF11914.8 EMC79487.1 - 0.0038 17.4 1.0 0.0038 17.4 1.0 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF3432) Keratin PF02422.16 EMC79488.1 - 5.7e-35 118.9 11.1 9.5e-35 118.2 11.1 1.5 1 1 0 1 1 1 1 Keratin Keratin PF02422.16 EMC79489.1 - 5.7e-35 118.9 11.7 1.1e-34 118.0 11.7 1.5 1 1 0 1 1 1 1 Keratin Keratin PF02422.16 EMC79490.1 - 1.9e-36 123.6 7.5 2.5e-36 123.3 7.5 1.2 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC79491.1 - 1.1e-37 127.6 10.9 1.2e-37 127.4 10.9 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC79493.1 - 6.9e-40 134.7 11.8 7.4e-40 134.6 11.8 1.0 1 0 0 1 1 1 1 Keratin CALCOCO1 PF07888.11 EMC79493.1 - 0.058 12.3 0.2 0.062 12.2 0.2 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Keratin PF02422.16 EMC79494.1 - 1.7e-42 143.0 9.4 1.9e-42 142.9 9.4 1.0 1 0 0 1 1 1 1 Keratin CALCOCO1 PF07888.11 EMC79494.1 - 0.087 11.7 0.2 0.098 11.5 0.2 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Keratin PF02422.16 EMC79495.1 - 1.7e-42 143.0 9.4 1.9e-42 142.9 9.4 1.0 1 0 0 1 1 1 1 Keratin CALCOCO1 PF07888.11 EMC79495.1 - 0.087 11.7 0.2 0.098 11.5 0.2 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Keratin PF02422.16 EMC79496.1 - 1.7e-42 143.0 9.4 1.9e-42 142.9 9.4 1.0 1 0 0 1 1 1 1 Keratin CALCOCO1 PF07888.11 EMC79496.1 - 0.087 11.7 0.2 0.098 11.5 0.2 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like zf-C3HC4_3 PF13920.6 EMC79497.1 - 3e-07 30.2 9.1 3e-07 30.2 9.1 4.1 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC79497.1 - 4.6e-06 26.4 12.1 4.6e-06 26.4 12.1 3.7 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC79497.1 - 1e-05 25.4 10.9 1e-05 25.4 10.9 3.5 3 1 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EMC79497.1 - 1.6e-05 24.7 13.5 1.6e-05 24.7 13.5 3.6 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC79497.1 - 8.2e-05 22.9 12.2 8.2e-05 22.9 12.2 4.1 2 1 2 4 4 4 1 Ring finger domain zf-RING_5 PF14634.6 EMC79497.1 - 0.00031 20.6 9.9 0.00031 20.6 9.9 4.1 3 1 0 3 3 3 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC79497.1 - 0.0041 16.9 9.6 0.0041 16.9 9.6 3.4 3 1 1 4 4 4 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 EMC79497.1 - 0.7 9.8 19.6 0.15 11.9 4.0 3.1 3 0 0 3 3 3 0 zf-RING of BARD1-type protein Yae1_N PF09811.9 EMC79498.1 - 5.7e-18 64.3 64.4 1.8e+04 -28.7 64.4 6.0 1 1 0 1 1 1 0 Essential protein Yae1, N terminal Pkinase PF00069.25 EMC79500.1 - 3e-74 249.7 0.0 4.9e-74 249.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC79500.1 - 2e-34 119.1 0.0 3.4e-34 118.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EMC79500.1 - 8.7e-05 21.6 0.5 0.00021 20.4 0.5 1.6 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 EMC79500.1 - 0.0018 18.0 0.3 1.2 8.7 0.0 2.6 1 1 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EMC79500.1 - 0.0051 16.4 0.8 0.012 15.2 0.8 1.6 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 EMC79500.1 - 0.4 9.4 0.0 0.4 9.4 0.0 2.5 3 0 0 3 3 3 0 Fungal protein kinase APH PF01636.23 EMC79500.1 - 2.3 8.1 3.7 2.8 7.8 0.2 2.6 3 1 0 4 4 4 0 Phosphotransferase enzyme family F5_F8_type_C PF00754.25 EMC79501.1 - 1.6e-30 105.9 0.7 1.6e-30 105.9 0.7 1.4 2 0 0 2 2 2 1 F5/8 type C domain KorB_C PF06613.11 EMC79501.1 - 0.00096 19.1 0.3 0.0053 16.7 0.0 2.0 2 0 0 2 2 2 1 KorB C-terminal beta-barrel domain Metallophos PF00149.28 EMC79502.1 - 2e-27 97.0 0.1 4.1e-27 96.0 0.1 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase EF-hand_1 PF00036.32 EMC79502.1 - 4.6e-18 63.3 0.7 3.6e-05 23.0 0.3 3.6 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EMC79502.1 - 1.8e-17 63.5 0.9 9.8e-10 38.7 1.2 2.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EMC79502.1 - 1.3e-14 52.7 0.2 0.0038 17.0 0.1 3.8 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 EMC79502.1 - 6.8e-11 41.2 0.3 0.0009 18.6 0.2 3.6 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EMC79502.1 - 2.8e-09 36.7 0.2 0.0067 16.3 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain pair PPP5 PF08321.12 EMC79502.1 - 2.6e-07 30.9 0.0 5.7e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 PPP5 TPR repeat region IQ PF00612.27 EMC79502.1 - 0.052 13.4 0.8 0.12 12.2 0.8 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif EF-hand_4 PF12763.7 EMC79502.1 - 0.19 11.7 1.0 4.5 7.3 0.1 2.5 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Glyco_hydro_15 PF00723.21 EMC79503.1 - 6.1e-181 602.1 0.0 7.2e-181 601.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 E1_dh PF00676.20 EMC79504.1 - 7.2e-123 409.3 0.0 8.5e-123 409.1 0.0 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 EMC79504.1 - 0.00097 18.9 0.3 0.0022 17.8 0.3 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 EMC79504.1 - 0.0047 16.2 0.0 0.0077 15.5 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase DUF2776 PF10951.8 EMC79504.1 - 0.19 10.9 0.0 0.28 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2776) DUF4071 PF13281.6 EMC79505.1 - 1.3e-165 550.9 1.3 3e-165 549.7 1.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4071) Pkinase PF00069.25 EMC79505.1 - 3.1e-64 216.9 0.0 6.2e-64 215.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC79505.1 - 8.7e-42 143.2 0.0 1.6e-41 142.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC79505.1 - 0.0014 18.0 0.0 0.0048 16.3 0.0 1.9 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMC79505.1 - 0.0033 16.3 0.0 0.0077 15.1 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase SLIDE PF09111.10 EMC79505.1 - 0.036 14.1 1.0 0.11 12.5 0.5 2.2 2 0 0 2 2 2 0 SLIDE TPD52 PF04201.15 EMC79505.1 - 5.9 6.5 7.5 3 7.5 1.8 2.9 3 0 0 3 3 3 0 Tumour protein D52 family SH3_9 PF14604.6 EMC79506.1 - 2.4e-35 120.2 0.7 2.1e-16 59.5 0.1 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 EMC79506.1 - 6.3e-28 96.2 0.9 2.7e-13 49.4 0.1 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 EMC79506.1 - 1.9e-27 94.6 2.0 4.1e-13 48.7 0.2 2.4 2 0 0 2 2 2 2 SH3 domain XFP PF03894.15 EMC79506.1 - 0.0016 18.2 0.0 1.6 8.5 0.0 2.4 2 0 0 2 2 2 2 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase Tmemb_cc2 PF10267.9 EMC79506.1 - 0.0027 16.9 0.5 0.0041 16.3 0.5 1.2 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein COG2 PF06148.11 EMC79506.1 - 0.03 14.4 3.9 0.051 13.7 3.9 1.4 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 YkyA PF10368.9 EMC79506.1 - 0.35 10.5 6.1 0.84 9.3 6.1 1.5 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein PDEase_I PF00233.19 EMC79507.1 - 3.8e-87 292.0 4.8 3.8e-87 292.0 4.8 2.0 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase WD40 PF00400.32 EMC79508.1 - 5.9e-07 30.1 1.4 0.62 11.0 0.0 5.5 6 0 0 6 6 6 2 WD domain, G-beta repeat NDUFV3 PF15880.5 EMC79509.1 - 3e-15 55.9 0.4 6.2e-15 54.9 0.4 1.5 1 0 0 1 1 1 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial Hydrolase_6 PF13344.6 EMC79509.1 - 1.1 9.4 5.1 1.9 8.6 0.8 2.4 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Meis_PKNOX_N PF16493.5 EMC79510.1 - 4.4e-37 126.3 0.1 8.5e-37 125.4 0.1 1.5 1 0 0 1 1 1 1 N-terminal of Homeobox Meis and PKNOX1 Homeobox_KN PF05920.11 EMC79510.1 - 7.7e-20 70.5 1.2 1.9e-19 69.2 1.2 1.7 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EMC79510.1 - 4.9e-08 32.7 0.3 1e-07 31.7 0.3 1.5 1 0 0 1 1 1 1 Homeodomain PALP PF00291.25 EMC79512.1 - 4.1e-64 216.8 0.0 4.9e-64 216.6 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 EMC79512.1 - 4.6e-06 27.0 0.0 0.00018 21.9 0.0 2.9 3 0 0 3 3 3 1 CBS domain Poxvirus_B22R_C PF13168.6 EMC79512.1 - 0.043 13.3 0.0 0.081 12.4 0.0 1.3 1 0 0 1 1 1 0 Poxvirus B22R protein C-terminal Glyco_tran_WecB PF03808.13 EMC79512.1 - 0.18 11.7 0.0 0.46 10.4 0.0 1.7 1 1 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family zf-CCCH PF00642.24 EMC79513.1 - 9.7e-14 50.9 17.1 1.1e-06 28.4 3.3 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 EMC79513.1 - 9e-07 28.6 0.0 1.5e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 EMC79513.1 - 2.7e-05 24.0 14.4 0.013 15.5 2.9 2.5 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 EMC79513.1 - 0.00037 21.2 9.3 0.11 13.3 0.3 2.9 2 1 1 3 3 3 2 Torus domain KMP11 PF03037.16 EMC79513.1 - 0.016 16.0 0.5 0.71 10.7 0.3 2.2 2 0 0 2 2 2 0 Kinetoplastid membrane protein 11 Nup35_RRM_2 PF14605.6 EMC79513.1 - 0.058 13.4 0.1 0.1 12.6 0.1 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif zf-CCCH_3 PF15663.5 EMC79513.1 - 0.093 13.0 5.6 1.6 9.0 0.3 2.4 2 0 0 2 2 2 0 Zinc-finger containing family Crystallin PF00525.18 EMC79514.1 - 7.6e-27 93.2 1.8 1.3e-26 92.5 1.8 1.4 1 0 0 1 1 1 1 Alpha crystallin A chain, N terminal HSP20 PF00011.21 EMC79514.1 - 2.3e-23 82.3 0.0 2.8e-23 82.0 0.0 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family YabA PF06156.13 EMC79515.1 - 0.002 18.7 1.9 0.0074 16.9 1.9 2.0 1 0 0 1 1 1 1 Initiation control protein YabA VHS PF00790.19 EMC79515.1 - 0.006 16.4 0.1 0.5 10.2 0.0 2.5 2 0 0 2 2 2 1 VHS domain DUF383 PF04063.14 EMC79515.1 - 0.0071 16.0 0.2 0.015 14.9 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF383) Exonuc_VII_L PF02601.15 EMC79515.1 - 0.015 14.9 2.2 0.022 14.4 2.2 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit RasGEF_N_2 PF14663.6 EMC79515.1 - 0.016 15.6 0.7 0.11 12.9 0.1 2.5 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain PEP-utilisers_N PF05524.13 EMC79515.1 - 0.054 13.7 1.3 0.32 11.2 0.6 2.2 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal UPF0242 PF06785.11 EMC79515.1 - 0.31 11.1 9.5 0.032 14.4 5.2 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF1664 PF07889.12 EMC79515.1 - 0.42 10.7 6.0 14 5.7 0.1 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Jnk-SapK_ap_N PF09744.9 EMC79515.1 - 0.73 10.1 13.3 0.041 14.1 6.7 2.3 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 Mis14 PF08641.12 EMC79515.1 - 1.5 9.2 7.4 0.26 11.6 3.4 1.8 2 0 0 2 2 2 0 Kinetochore protein Mis14 like Lectin_N PF03954.14 EMC79515.1 - 2 8.2 7.4 4.1 7.1 3.9 2.8 2 1 0 2 2 2 0 Hepatic lectin, N-terminal domain APG6_N PF17675.1 EMC79515.1 - 4 8.0 17.3 0.23 12.0 9.6 2.5 3 0 0 3 3 3 0 Apg6 coiled-coil region YlqD PF11068.8 EMC79515.1 - 4.7 7.6 9.1 1 9.7 5.2 1.8 2 0 0 2 2 2 0 YlqD protein AAA_23 PF13476.6 EMC79515.1 - 8.6 6.8 7.9 15 6.1 7.1 1.8 2 0 0 2 2 2 0 AAA domain Nop52 PF05997.12 EMC79516.1 - 6.8e-62 209.1 3.8 6.8e-62 209.1 3.8 1.9 2 0 0 2 2 2 1 Nucleolar protein,Nop52 Phos_pyr_kin PF08543.12 EMC79517.1 - 1e-18 67.6 0.1 1.7e-18 66.9 0.1 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 EMC79517.1 - 4.8e-11 42.5 0.1 1.3e-10 41.1 0.1 1.7 1 1 0 1 1 1 1 pfkB family carbohydrate kinase HpcH_HpaI PF03328.14 EMC79517.1 - 0.0056 15.8 0.0 0.014 14.6 0.0 1.6 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family SRR1 PF07985.12 EMC79517.1 - 0.0088 16.1 0.1 0.041 13.9 0.0 2.0 2 0 0 2 2 2 1 SRR1 SDA1 PF05285.12 EMC79518.1 - 0.0065 15.9 72.9 0.014 14.9 72.9 1.6 1 0 0 1 1 1 1 SDA1 BUD22 PF09073.10 EMC79518.1 - 5.7 6.2 70.4 9.2 5.5 70.4 1.2 1 0 0 1 1 1 0 BUD22 Acyltransf_C PF16076.5 EMC79519.1 - 1e-28 99.2 0.4 1.9e-28 98.3 0.4 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus Acyltransferase PF01553.21 EMC79519.1 - 5.4e-15 55.2 0.0 8.7e-15 54.5 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase TRAPPC10 PF12584.8 EMC79521.1 - 1.7e-42 144.8 0.0 3.8e-42 143.6 0.0 1.6 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 WD40 PF00400.32 EMC79522.1 - 1.3e-32 111.2 22.8 1.1e-07 32.4 0.0 11.4 12 1 0 12 12 12 4 WD domain, G-beta repeat Utp12 PF04003.12 EMC79522.1 - 4.7e-25 88.0 0.8 7.3e-25 87.3 0.8 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EMC79522.1 - 1.9e-18 66.6 0.0 0.01 16.1 0.0 9.4 4 3 6 10 10 10 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMC79522.1 - 2.8e-07 29.8 0.2 0.42 9.5 0.1 4.3 2 2 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EMC79522.1 - 1.4e-06 28.3 1.7 0.19 11.6 0.1 4.7 3 2 2 5 5 5 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 EMC79522.1 - 1.2e-05 25.2 0.1 0.12 12.4 0.0 4.9 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 EMC79522.1 - 5.4e-05 22.7 0.3 0.00078 18.9 0.1 2.9 2 1 0 2 2 2 1 WD40-like domain DUF1513 PF07433.11 EMC79522.1 - 0.009 15.1 0.0 0.17 10.9 0.0 2.8 2 1 0 3 3 3 1 Protein of unknown function (DUF1513) Nup160 PF11715.8 EMC79522.1 - 0.062 11.9 4.1 0.059 12.0 0.2 2.5 2 1 0 2 2 2 0 Nucleoporin Nup120/160 Utp13 PF08625.11 EMC79522.1 - 0.089 12.7 0.6 0.27 11.1 0.6 1.9 1 1 0 1 1 1 0 Utp13 specific WD40 associated domain DJ-1_PfpI PF01965.24 EMC79523.1 - 2.4e-06 27.5 0.2 7.2e-06 25.9 0.2 1.8 1 1 0 1 1 1 1 DJ-1/PfpI family Catalase_C PF18011.1 EMC79523.1 - 0.067 12.8 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 C-terminal domain found in long catalases Ig_3 PF13927.6 EMC79524.1 - 4.7e-12 46.3 1.7 4.4e-05 24.0 0.5 2.6 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 EMC79524.1 - 5.2e-10 39.5 2.9 1.1e-08 35.2 0.2 2.4 2 1 0 2 2 2 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC79524.1 - 8.3e-10 38.6 0.2 4.4e-09 36.3 0.2 2.2 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain ig PF00047.25 EMC79524.1 - 1.7e-08 34.5 3.4 0.0035 17.5 0.1 4.3 2 2 1 3 3 3 2 Immunoglobulin domain I-set PF07679.16 EMC79524.1 - 2.9e-08 33.7 0.1 0.011 15.8 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC79524.1 - 8.1e-07 29.3 2.4 0.0066 16.8 0.3 3.1 2 1 0 2 2 2 2 Immunoglobulin domain C1-set PF07654.15 EMC79524.1 - 0.00042 20.6 3.2 0.0044 17.4 0.1 3.1 2 1 0 3 3 3 1 Immunoglobulin C1-set domain Lep_receptor_Ig PF06328.11 EMC79524.1 - 0.0014 18.5 2.6 0.045 13.7 0.0 2.9 2 1 1 3 3 3 1 Ig-like C2-type domain DUF2207 PF09972.9 EMC79524.1 - 0.0032 16.3 0.0 0.0045 15.8 0.0 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) MLANA PF14991.6 EMC79524.1 - 0.012 15.9 1.0 0.012 15.9 1.0 2.1 2 1 0 2 2 2 0 Protein melan-A DUF2987 PF11205.8 EMC79524.1 - 0.037 13.9 0.1 0.076 12.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2987) Herpes_gE PF02480.16 EMC79524.1 - 0.052 12.3 0.6 0.44 9.2 0.4 1.9 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein E DUF4366 PF14283.6 EMC79524.1 - 0.082 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) DUF4328 PF14219.6 EMC79524.1 - 0.094 12.3 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4328) FUN14 PF04930.15 EMC79526.1 - 1.5e-29 102.2 2.7 1.9e-29 101.9 2.7 1.1 1 0 0 1 1 1 1 FUN14 family EutA PF06277.11 EMC79526.1 - 0.053 12.4 0.1 0.063 12.1 0.1 1.0 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutA SPC12 PF06645.13 EMC79526.1 - 0.56 10.3 2.9 0.96 9.6 0.9 2.0 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) DUF1126 PF06565.12 EMC79527.1 - 3.9e-76 251.6 0.4 5.1e-32 109.8 0.0 4.3 3 1 0 3 3 3 3 DUF1126 PH-like domain Cys_knot PF00007.22 EMC79528.1 - 3e-06 27.5 13.3 4.4e-06 26.9 13.3 1.3 1 0 0 1 1 1 1 Cystine-knot domain DAN PF03045.15 EMC79528.1 - 6.3e-06 26.2 9.6 7.5e-06 25.9 9.6 1.1 1 0 0 1 1 1 1 DAN domain Amino_oxidase PF01593.24 EMC79529.1 - 4.7e-77 260.2 0.0 5.4e-77 260.0 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EMC79529.1 - 1.7e-06 28.1 0.0 5e-06 26.6 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EMC79530.1 - 1.1e-69 235.9 0.0 1.4e-69 235.6 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EMC79530.1 - 2.9e-10 40.2 0.0 2.3e-09 37.4 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain PSP1 PF04468.12 EMC79531.1 - 0.02 15.1 0.1 0.052 13.8 0.1 1.7 1 0 0 1 1 1 0 PSP1 C-terminal conserved region Pkinase PF00069.25 EMC79532.1 - 6.5e-65 219.1 0.0 1.2e-64 218.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Guanylate_kin PF00625.21 EMC79532.1 - 9.5e-62 207.9 0.1 1.8e-61 207.0 0.1 1.5 1 0 0 1 1 1 1 Guanylate kinase L27 PF02828.16 EMC79532.1 - 3.2e-27 94.0 12.5 3.7e-16 58.6 0.4 4.2 4 0 0 4 4 4 2 L27 domain Pkinase_Tyr PF07714.17 EMC79532.1 - 3.5e-27 95.3 0.0 5.8e-27 94.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PDZ PF00595.24 EMC79532.1 - 7.1e-17 61.5 0.5 1.7e-16 60.3 0.5 1.7 1 0 0 1 1 1 1 PDZ domain SH3_2 PF07653.17 EMC79532.1 - 2e-12 46.6 0.0 5.3e-12 45.2 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC79532.1 - 3.1e-08 33.1 0.0 1e-07 31.5 0.1 1.9 2 0 0 2 2 2 1 SH3 domain Pkinase_fungal PF17667.1 EMC79532.1 - 7.3e-06 25.0 0.0 0.0002 20.2 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase PDZ_6 PF17820.1 EMC79532.1 - 4.8e-05 23.1 0.0 0.00015 21.6 0.0 1.8 1 0 0 1 1 1 1 PDZ domain SH3_9 PF14604.6 EMC79532.1 - 6.4e-05 22.7 0.0 0.00017 21.4 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Kinase-like PF14531.6 EMC79532.1 - 0.0046 16.3 0.0 0.011 15.1 0.0 1.6 1 0 0 1 1 1 1 Kinase-like PDZ_2 PF13180.6 EMC79532.1 - 0.0079 16.5 0.0 0.023 15.0 0.0 1.8 1 0 0 1 1 1 1 PDZ domain LRR_8 PF13855.6 EMC79533.1 - 5.5e-57 189.4 20.4 4.5e-17 61.6 0.9 4.8 2 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EMC79533.1 - 5.8e-27 93.3 24.0 1.4e-05 25.3 0.2 6.5 4 2 3 7 7 7 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC79533.1 - 9.1e-21 74.2 0.3 9.9e-10 38.5 0.0 3.2 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC79533.1 - 2.2e-13 50.1 7.8 2.6e-05 23.8 0.3 3.3 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 EMC79533.1 - 3.5e-10 39.0 26.2 1.5 9.7 0.2 9.6 9 1 1 10 10 10 4 Leucine Rich Repeat LRRNT PF01462.18 EMC79533.1 - 2.7e-06 26.9 6.5 5.3e-06 26.0 4.7 2.4 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 EMC79533.1 - 0.0011 18.8 24.2 2.2 8.5 0.9 7.8 9 0 0 9 9 9 2 Leucine Rich repeat TPKR_C2 PF16920.5 EMC79533.1 - 0.038 14.1 3.5 0.85 9.8 1.2 3.4 3 0 0 3 3 3 0 Tyrosine-protein kinase receptor C2 Ig-like domain LRR_2 PF07723.13 EMC79533.1 - 0.064 13.9 0.3 48 4.8 0.0 4.0 3 0 0 3 3 3 0 Leucine Rich Repeat Ribosomal_L2_C PF03947.18 EMC79534.1 - 1.1e-48 164.6 3.0 1.6e-48 164.0 3.0 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EMC79534.1 - 5.5e-19 67.9 0.1 1.9e-18 66.2 0.1 1.9 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain UCH PF00443.29 EMC79535.1 - 5.4e-50 170.3 0.5 3.3e-49 167.7 0.1 2.5 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMC79535.1 - 3.1e-27 96.0 0.0 9.1e-26 91.2 0.0 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF1722 PF08349.11 EMC79535.1 - 0.055 13.8 0.0 15 5.9 0.0 3.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1722) Vps23_core PF09454.10 EMC79535.1 - 0.07 13.1 0.5 0.48 10.4 0.1 2.8 3 0 0 3 3 3 0 Vps23 core domain FAST_1 PF06743.15 EMC79535.1 - 0.11 12.5 0.2 1.3 9.0 0.0 2.9 3 0 0 3 3 3 0 FAST kinase-like protein, subdomain 1 Cas9_a PF18470.1 EMC79535.1 - 0.18 11.3 0.7 0.46 10.0 0.6 1.7 1 1 0 1 1 1 0 Cas9 alpha-helical lobe domain Med14 PF08638.11 EMC79536.1 - 1e-51 175.1 0.4 2.5e-51 173.8 0.0 1.9 2 0 0 2 2 2 1 Mediator complex subunit MED14 RE_SinI PF09570.10 EMC79536.1 - 0.1 11.8 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 SinI restriction endonuclease Renin_r PF07850.14 EMC79537.1 - 1.1e-36 125.4 1.2 1.6e-36 124.8 1.2 1.3 1 0 0 1 1 1 1 Renin receptor-like protein Glycophorin_A PF01102.18 EMC79537.1 - 0.065 13.5 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Glycophorin A CbtA PF09490.10 EMC79537.1 - 0.076 12.8 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) DUF2273 PF10031.9 EMC79537.1 - 0.092 12.8 1.0 0.16 12.0 1.0 1.4 1 0 0 1 1 1 0 Small integral membrane protein (DUF2273) Spot_14 PF07084.12 EMC79539.1 - 7.3e-55 185.3 0.0 8.7e-55 185.0 0.0 1.1 1 0 0 1 1 1 1 Thyroid hormone-inducible hepatic protein Spot 14 Tetraspanin PF00335.20 EMC79540.1 - 4.4e-47 160.7 8.6 5.3e-47 160.5 8.6 1.0 1 0 0 1 1 1 1 Tetraspanin family Adeno_E3_CR2 PF02439.15 EMC79540.1 - 3.8 7.3 7.1 0.66 9.8 0.8 2.4 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 OTCace PF00185.24 EMC79541.1 - 4.8e-54 182.7 0.0 6.7e-54 182.2 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 EMC79541.1 - 6.6e-43 146.3 0.0 1.2e-42 145.4 0.0 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain RCC1 PF00415.18 EMC79542.1 - 1.5e-74 246.4 15.7 1.3e-12 48.1 0.1 8.1 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EMC79542.1 - 4.9e-40 134.6 22.1 1.8e-08 34.0 0.1 8.1 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat Kelch_4 PF13418.6 EMC79542.1 - 0.0039 17.2 6.4 1.5 8.9 0.1 4.7 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EMC79542.1 - 0.0061 16.5 0.1 7.6 6.7 0.0 3.4 3 0 0 3 3 3 2 Kelch motif DUF1921 PF09081.10 EMC79542.1 - 0.15 12.3 0.0 1.2 9.4 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1921) DUF4174 PF13778.6 EMC79543.1 - 5.5e-31 107.5 0.0 7.4e-31 107.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4174) HYR PF02494.16 EMC79543.1 - 9.9e-29 99.5 0.0 1.8e-28 98.7 0.0 1.5 1 0 0 1 1 1 1 HYR domain Sushi PF00084.20 EMC79543.1 - 9.8e-25 86.9 27.0 5e-11 43.0 3.9 3.4 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) C2 PF00168.30 EMC79544.1 - 4.8e-44 148.9 0.8 1.8e-22 79.5 0.1 2.8 3 0 0 3 3 3 2 C2 domain FYVE_2 PF02318.16 EMC79544.1 - 1.5e-17 63.9 9.5 2.6e-17 63.1 9.5 1.4 1 0 0 1 1 1 1 FYVE-type zinc finger PI3K_C2 PF00792.24 EMC79544.1 - 0.029 14.3 0.3 0.57 10.1 0.1 2.3 2 0 0 2 2 2 0 Phosphoinositide 3-kinase C2 zf-B_box PF00643.24 EMC79544.1 - 9 6.5 13.6 8.8 6.6 0.4 2.9 2 1 0 2 2 2 0 B-box zinc finger Tctex-1 PF03645.13 EMC79545.1 - 1.9e-31 108.3 2.7 2.2e-31 108.1 2.7 1.1 1 0 0 1 1 1 1 Tctex-1 family S1-like PF14444.6 EMC79545.1 - 0.032 14.1 0.1 0.055 13.4 0.1 1.3 1 0 0 1 1 1 0 S1-like NAD_binding_6 PF08030.12 EMC79546.1 - 4.2e-37 127.7 0.0 6.7e-37 127.0 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EMC79546.1 - 8.2e-25 87.3 6.6 8.2e-25 87.3 6.6 1.8 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EMC79546.1 - 6.8e-22 77.6 0.2 1.6e-21 76.4 0.0 1.7 2 0 0 2 2 2 1 FAD-binding domain FAD_binding_6 PF00970.24 EMC79546.1 - 0.00014 22.2 0.0 0.00027 21.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EMC79546.1 - 0.025 15.2 0.0 0.11 13.1 0.0 2.1 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain XK-related PF09815.9 EMC79547.1 - 1e-60 205.6 22.3 1.2e-60 205.3 22.3 1.2 1 0 0 1 1 1 1 XK-related protein LANC_like PF05147.13 EMC79548.1 - 1.7e-57 194.6 0.0 2.1e-57 194.3 0.0 1.0 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein C5-epim_C PF06662.13 EMC79548.1 - 0.021 14.3 1.0 1.7 8.1 0.2 2.3 1 1 1 2 2 2 0 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_127 PF07944.12 EMC79548.1 - 0.08 11.4 0.0 0.34 9.3 0.0 1.6 1 1 1 2 2 2 0 Beta-L-arabinofuranosidase, GH127 Gla PF00594.20 EMC79549.1 - 9.5e-19 67.3 13.0 9.5e-19 67.3 13.0 1.8 2 0 0 2 2 2 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain RCR PF12273.8 EMC79549.1 - 0.0043 17.7 0.0 0.012 16.2 0.0 1.7 1 1 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red TMEM252 PF15664.5 EMC79549.1 - 0.017 14.8 1.1 0.12 12.1 0.2 2.3 2 0 0 2 2 2 0 Transmembrane protein 252 family DUF2207 PF09972.9 EMC79549.1 - 0.048 12.4 0.0 0.055 12.2 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4834 PF16118.5 EMC79549.1 - 0.088 13.8 1.3 0.12 13.3 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF488 PF04343.13 EMC79549.1 - 0.15 12.6 0.6 0.24 12.0 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF488 RIFIN PF02009.16 EMC79549.1 - 0.15 11.9 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 Rifin FeoB_associated PF12669.7 EMC79549.1 - 0.26 11.7 2.6 0.6 10.6 2.6 1.5 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Asp4 PF16996.5 EMC79549.1 - 0.36 10.6 3.3 0.87 9.4 3.3 1.6 1 0 0 1 1 1 0 Accessory secretory protein Sec Asp4 ASH PF15780.5 EMC79550.1 - 2.1e-08 34.3 4.6 0.95 9.7 0.1 5.7 6 1 1 7 7 7 4 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Motile_Sperm PF00635.26 EMC79550.1 - 6.5e-08 32.4 0.4 0.093 12.6 0.4 5.1 6 0 0 6 6 6 3 MSP (Major sperm protein) domain TMEM131_like PF12371.8 EMC79550.1 - 0.0011 19.2 2.0 0.0052 17.0 0.1 2.9 3 0 0 3 3 3 1 Transmembrane protein 131-like Gal-bind_lectin PF00337.22 EMC79551.1 - 0.039 13.5 0.0 0.15 11.6 0.0 1.9 2 1 1 3 3 3 0 Galactoside-binding lectin CAMSAP_CH PF11971.8 EMC79552.1 - 0.028 14.3 0.0 0.061 13.2 0.0 1.6 1 0 0 1 1 1 0 CAMSAP CH domain CH PF00307.31 EMC79552.1 - 0.041 14.1 0.0 0.15 12.3 0.0 2.0 2 0 0 2 2 2 0 Calponin homology (CH) domain ASH PF15780.5 EMC79553.1 - 0.041 14.1 0.0 0.08 13.2 0.0 1.4 1 1 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Glu_cys_ligase PF04262.14 EMC79554.1 - 0.064 11.9 0.0 0.074 11.7 0.0 1.1 1 0 0 1 1 1 0 Glutamate-cysteine ligase ArfGap PF01412.18 EMC79555.1 - 1.3e-40 138.1 0.1 3.2e-40 136.8 0.1 1.7 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Ank_2 PF12796.7 EMC79555.1 - 2.6e-11 43.9 0.1 5e-11 43.0 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EMC79555.1 - 3e-10 40.1 0.1 2.4e-06 27.8 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat PH PF00169.29 EMC79555.1 - 1.4e-09 38.4 3.5 5.1e-05 23.7 0.1 3.4 4 0 0 4 4 4 2 PH domain Ank_5 PF13857.6 EMC79555.1 - 1.8e-09 37.6 0.3 4.8e-09 36.3 0.3 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC79555.1 - 7.1e-08 32.9 0.1 1.4e-05 25.6 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC79555.1 - 4.5e-06 26.6 0.1 0.00028 21.1 0.0 3.0 3 0 0 3 3 2 1 Ankyrin repeat PH_6 PF15406.6 EMC79555.1 - 0.0021 18.3 0.4 0.0021 18.3 0.4 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 EMC79555.1 - 0.0033 17.8 7.1 0.24 11.8 0.3 3.6 4 0 0 4 4 4 2 Pleckstrin homology domain MAGI_u1 PF16663.5 EMC79555.1 - 0.017 15.1 0.9 0.048 13.7 0.1 2.2 2 0 0 2 2 2 0 Unstructured region on MAGI TackOD1 PF18551.1 EMC79555.1 - 0.046 13.4 0.1 0.078 12.6 0.1 1.3 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 PH_4 PF15404.6 EMC79555.1 - 0.098 12.4 0.1 0.32 10.8 0.1 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain PH_8 PF15409.6 EMC79555.1 - 0.12 12.7 0.7 3.3 8.1 0.1 2.5 2 0 0 2 2 2 0 Pleckstrin homology domain Pap_E4 PF02711.14 EMC79555.1 - 0.5 11.4 6.7 0.45 11.5 0.7 2.9 3 0 0 3 3 2 0 E4 protein Homeodomain PF00046.29 EMC79556.1 - 5.1e-24 83.9 6.2 8.4e-24 83.2 6.2 1.4 1 0 0 1 1 1 1 Homeodomain REV PF00424.18 EMC79556.1 - 0.059 13.4 0.4 0.19 11.8 0.1 2.0 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) Homeobox_KN PF05920.11 EMC79556.1 - 0.12 12.3 0.1 0.12 12.3 0.1 1.7 2 0 0 2 2 2 0 Homeobox KN domain Ank_2 PF12796.7 EMC79557.1 - 2.8e-28 98.3 1.5 3.1e-11 43.7 0.0 3.7 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC79557.1 - 1.5e-25 88.9 10.6 1.3e-07 31.7 0.0 4.4 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC79557.1 - 3.8e-25 87.9 12.7 3.1e-07 30.8 0.1 7.2 4 2 4 8 8 8 5 Ankyrin repeats (many copies) Ank PF00023.30 EMC79557.1 - 1.3e-22 79.2 19.2 0.00014 22.2 0.0 7.2 7 0 0 7 7 7 6 Ankyrin repeat Ank_3 PF13606.6 EMC79557.1 - 5.8e-21 72.3 12.6 0.00019 21.6 0.0 7.2 7 0 0 7 7 7 4 Ankyrin repeat SOCS_box PF07525.16 EMC79557.1 - 6.1e-09 36.1 6.2 6.1e-09 36.1 6.2 2.3 2 0 0 2 2 2 1 SOCS box YjeF_N PF03853.15 EMC79557.1 - 0.089 12.7 0.8 0.61 10.0 0.4 2.2 1 1 1 2 2 2 0 YjeF-related protein N-terminus AAA PF00004.29 EMC79558.1 - 7.9e-17 61.9 0.0 1.9e-16 60.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IQ PF00612.27 EMC79558.1 - 5.2e-06 25.8 0.0 1.4e-05 24.5 0.0 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif FGAR-AT_linker PF18072.1 EMC79558.1 - 0.26 11.9 1.5 1.5 9.4 0.2 2.8 2 0 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain RuvB_N PF05496.12 EMC79558.1 - 0.38 10.5 2.2 0.69 9.6 0.1 2.5 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain Presenilin PF01080.17 EMC79558.1 - 4.9 5.8 7.0 8.1 5.1 7.0 1.3 1 0 0 1 1 1 0 Presenilin 7tm_1 PF00001.21 EMC79559.1 - 3.1e-49 167.7 25.2 6.3e-49 166.7 25.2 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CSN8_PSD8_EIF3K PF10075.9 EMC79560.1 - 3.8e-36 124.2 0.0 5.1e-36 123.8 0.0 1.1 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family PCI PF01399.27 EMC79560.1 - 0.034 14.7 0.0 0.054 14.0 0.0 1.3 1 0 0 1 1 1 0 PCI domain Rab_eff_C PF04698.12 EMC79561.1 - 8.9e-41 140.0 16.2 1.6e-40 139.1 16.2 1.3 1 0 0 1 1 1 1 Rab effector MyRIP/melanophilin C-terminus FYVE_2 PF02318.16 EMC79561.1 - 1.8e-32 112.0 22.8 9.6e-31 106.5 13.8 3.4 2 1 0 2 2 2 1 FYVE-type zinc finger DUF1664 PF07889.12 EMC79561.1 - 0.1 12.7 0.2 0.1 12.7 0.2 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Phage_tail_NK PF16532.5 EMC79561.1 - 0.13 11.9 0.1 0.36 10.4 0.1 1.7 1 0 0 1 1 1 0 Sf6-type phage tail needle knob or tip of some Caudovirales PEGA PF08308.11 EMC79561.1 - 0.18 11.7 0.4 0.33 10.9 0.4 1.4 1 0 0 1 1 1 0 PEGA domain DUF16 PF01519.16 EMC79561.1 - 0.18 12.3 0.2 0.18 12.3 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function DUF16 DUF4407 PF14362.6 EMC79561.1 - 5.5 6.3 9.0 13 5.1 9.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SlyX PF04102.12 EMC79561.1 - 6.5 7.4 7.9 7.9 7.2 0.5 3.2 2 1 0 2 2 2 0 SlyX Prolactin_RP PF15172.6 EMC79562.1 - 1.2e-21 76.0 2.8 1.7e-21 75.5 2.8 1.3 1 0 0 1 1 1 1 Prolactin-releasing peptide Ras PF00071.22 EMC79563.1 - 1.9e-54 183.6 0.1 2.3e-54 183.4 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC79563.1 - 3.6e-30 104.7 0.0 5.5e-30 104.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC79563.1 - 4.2e-15 55.6 0.0 5.4e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC79563.1 - 1.3e-06 28.4 0.0 2.7e-06 27.4 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC79563.1 - 0.0011 18.9 0.1 1 9.3 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EMC79563.1 - 0.0053 16.1 0.0 0.0061 15.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EMC79563.1 - 0.0075 15.8 0.0 0.017 14.7 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain CPT PF07931.12 EMC79563.1 - 0.014 15.2 0.0 0.028 14.3 0.0 1.4 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein FeoB_N PF02421.18 EMC79563.1 - 0.16 11.5 0.4 2.7 7.5 0.4 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B LRRFIP PF09738.9 EMC79564.1 - 8.7e-64 215.8 48.4 1.7e-44 152.5 25.1 5.5 2 1 2 4 4 3 2 LRRFIP family APG6_N PF17675.1 EMC79564.1 - 0.0023 18.4 60.8 0.024 15.2 11.4 4.5 1 1 3 4 4 4 1 Apg6 coiled-coil region BRE1 PF08647.11 EMC79564.1 - 0.0053 16.8 10.3 0.0053 16.8 10.3 5.1 3 2 1 4 4 4 1 BRE1 E3 ubiquitin ligase Seryl_tRNA_N PF02403.22 EMC79564.1 - 0.0075 16.5 6.8 0.0075 16.5 6.8 5.3 3 2 0 4 4 4 1 Seryl-tRNA synthetase N-terminal domain TPR_MLP1_2 PF07926.12 EMC79564.1 - 0.0099 15.9 56.5 0.018 15.1 11.7 4.6 2 2 1 3 3 3 1 TPR/MLP1/MLP2-like protein DUF3584 PF12128.8 EMC79564.1 - 0.015 12.8 41.2 0.0024 15.5 16.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Tweety PF04906.13 EMC79564.1 - 0.19 10.4 18.0 0.21 10.2 3.0 3.9 2 2 3 5 5 5 0 Tweety ATG16 PF08614.11 EMC79564.1 - 0.22 11.7 54.7 0.03 14.5 13.7 4.4 3 1 1 4 4 4 0 Autophagy protein 16 (ATG16) HALZ PF02183.18 EMC79564.1 - 0.28 11.4 27.5 1.5 9.1 0.1 5.8 5 1 1 6 6 6 0 Homeobox associated leucine zipper DUF724 PF05266.14 EMC79564.1 - 0.61 9.9 48.1 0.2 11.5 6.7 4.3 2 2 2 4 4 4 0 Protein of unknown function (DUF724) FPP PF05911.11 EMC79564.1 - 0.63 8.2 45.2 3.4 5.7 23.5 2.3 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil Fez1 PF06818.15 EMC79564.1 - 1.6 9.1 49.3 0.15 12.5 9.2 3.4 1 1 2 3 3 3 0 Fez1 DUF3450 PF11932.8 EMC79564.1 - 2.6 7.3 51.1 0.025 13.9 5.2 4.7 2 2 3 5 5 5 0 Protein of unknown function (DUF3450) Fib_alpha PF08702.10 EMC79564.1 - 2.7 8.1 36.8 1.2 9.3 11.6 4.1 2 2 2 4 4 4 0 Fibrinogen alpha/beta chain family CALCOCO1 PF07888.11 EMC79564.1 - 6.2 5.6 49.4 1.6 7.5 22.4 2.4 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like FAM76 PF16046.5 EMC79564.1 - 6.9 5.9 35.8 4.4 6.6 10.7 2.8 2 1 0 2 2 2 0 FAM76 protein DUF812 PF05667.11 EMC79564.1 - 8.8 5.1 49.1 2.3 7.0 14.6 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF812) RRM_1 PF00076.22 EMC79566.1 - 7.8e-10 38.4 0.0 1.4e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SET_assoc PF11767.8 EMC79566.1 - 0.025 14.2 0.1 0.078 12.6 0.1 1.9 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated RRM_5 PF13893.6 EMC79566.1 - 0.035 13.7 0.0 0.071 12.7 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMC79566.1 - 0.043 13.7 0.0 0.084 12.7 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif RAMP PF04901.13 EMC79567.1 - 6.7e-46 154.8 0.1 7.8e-46 154.6 0.1 1.1 1 0 0 1 1 1 1 Receptor activity modifying family UQ_con PF00179.26 EMC79568.1 - 1.6e-29 102.4 0.0 1.8e-29 102.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme IL28A PF15177.6 EMC79569.1 - 6.8e-17 61.8 0.2 7.1e-17 61.7 0.2 1.0 1 0 0 1 1 1 1 Interleukin-28A Ring_hydroxyl_B PF00866.18 EMC79569.1 - 0.097 12.7 0.0 0.097 12.7 0.0 1.0 1 0 0 1 1 1 0 Ring hydroxylating beta subunit Methyltransf_11 PF08241.12 EMC79570.1 - 1e-24 87.0 0.0 2.6e-24 85.7 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC79570.1 - 2.5e-22 79.4 0.0 5.4e-22 78.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC79570.1 - 3.7e-15 56.0 0.0 5.3e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMC79570.1 - 3.3e-13 49.5 0.0 5.2e-13 48.9 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EMC79570.1 - 3.5e-13 49.7 0.0 5.1e-13 49.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC79570.1 - 2.5e-11 44.2 0.0 5.1e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EMC79570.1 - 3.6e-07 30.3 0.0 9e-07 29.0 0.0 1.6 1 1 0 1 1 1 1 Hypothetical methyltransferase TPMT PF05724.11 EMC79570.1 - 3.4e-05 23.6 0.0 5.2e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_29 PF03141.16 EMC79570.1 - 0.00021 20.0 0.0 0.00027 19.6 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase CMAS PF02353.20 EMC79570.1 - 0.00047 19.5 0.0 0.0012 18.3 0.0 1.6 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase N6_N4_Mtase PF01555.18 EMC79570.1 - 0.0012 18.6 0.0 0.21 11.2 0.0 2.2 2 0 0 2 2 2 1 DNA methylase PrmA PF06325.13 EMC79570.1 - 0.0026 17.2 0.0 0.004 16.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EMC79570.1 - 0.0034 16.9 0.0 0.011 15.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EMC79570.1 - 0.0046 17.0 0.0 0.008 16.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DUF938 PF06080.12 EMC79570.1 - 0.0063 16.3 0.0 0.019 14.7 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF938) tRNA_U5-meth_tr PF05958.11 EMC79570.1 - 0.011 14.8 0.0 0.015 14.3 0.0 1.2 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase FtsJ PF01728.19 EMC79570.1 - 0.014 15.6 0.0 0.47 10.5 0.0 2.1 1 1 0 2 2 2 0 FtsJ-like methyltransferase DREV PF05219.12 EMC79570.1 - 0.021 13.9 0.0 0.029 13.5 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_33 PF10017.9 EMC79570.1 - 0.032 13.4 0.0 0.067 12.3 0.0 1.5 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent DUF4817 PF16087.5 EMC79570.1 - 0.043 13.6 0.2 0.33 10.8 0.0 2.3 1 1 1 2 2 2 0 Helix-turn-helix domain (DUF4817) Methyltransf_15 PF09445.10 EMC79570.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_7 PF03492.15 EMC79570.1 - 0.18 11.0 0.0 11 5.1 0.0 2.3 2 0 0 2 2 2 0 SAM dependent carboxyl methyltransferase MREG PF15812.5 EMC79571.1 - 2.2e-70 235.7 4.0 2.6e-70 235.5 4.0 1.0 1 0 0 1 1 1 1 Melanoregulin AIP3 PF03915.13 EMC79571.1 - 0.012 14.8 0.2 0.014 14.5 0.2 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 COG5 PF10392.9 EMC79571.1 - 0.039 14.1 0.3 0.057 13.6 0.3 1.3 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Lipoprotein_6 PF01441.19 EMC79571.1 - 0.12 12.3 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Lipoprotein fn3 PF00041.21 EMC79572.1 - 1.6e-264 855.2 81.7 2.4e-20 72.7 0.6 17.3 17 0 0 17 17 17 17 Fibronectin type III domain fn1 PF00039.18 EMC79572.1 - 7.7e-149 483.6 166.4 4.9e-15 55.4 5.2 12.8 12 0 0 12 12 12 12 Fibronectin type I domain Pur_ac_phosph_N PF16656.5 EMC79572.1 - 7.2e-32 109.8 59.7 0.0009 19.8 0.0 19.8 16 7 0 16 16 16 9 Purple acid Phosphatase, N-terminal domain fn2 PF00040.19 EMC79572.1 - 5.5e-31 106.6 28.9 1.5e-16 60.4 6.5 3.9 3 0 0 3 3 2 2 Fibronectin type II domain DUF2369 PF10179.9 EMC79572.1 - 4.6e-26 91.0 13.8 0.16 12.4 0.0 13.9 14 1 1 15 15 14 7 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.10 EMC79572.1 - 4.5e-18 65.5 0.0 0.41 11.0 0.0 12.5 15 0 0 15 15 13 2 Interferon-alpha/beta receptor, fibronectin type III DUF4959 PF16323.5 EMC79572.1 - 1.1e-10 41.8 4.5 2 8.8 0.0 8.5 9 0 0 9 9 9 2 Domain of unknown function (DUF4959) DUF4912 PF16258.5 EMC79572.1 - 9.6e-07 29.0 0.0 3.3 8.0 0.0 7.1 9 0 0 9 9 8 1 Domain of unknown function (DUF4912) fn3_2 PF16893.5 EMC79572.1 - 0.0016 18.5 11.0 0.75 10.0 0.0 7.9 8 1 0 8 8 7 1 Fibronectin type III domain TILa PF12714.7 EMC79572.1 - 0.0031 17.4 1.5 0.0031 17.4 1.5 11.5 5 3 7 12 12 12 1 TILa domain MG4 PF17789.1 EMC79572.1 - 0.0075 16.4 0.1 0.095 12.9 0.2 2.9 2 0 0 2 2 2 1 Macroglobulin domain MG4 DUF1410 PF07198.11 EMC79572.1 - 0.013 15.9 6.5 38 4.9 0.0 7.2 8 0 0 8 8 7 0 Protein of unknown function (DUF1410) Glyco_hydro_66 PF13199.6 EMC79572.1 - 0.022 13.4 6.9 27 3.2 0.0 6.0 4 2 3 7 7 7 0 Glycosyl hydrolase family 66 Arylsulfotran_N PF17425.2 EMC79572.1 - 0.033 14.2 24.1 0.8 9.8 0.4 7.8 8 0 0 8 8 8 0 Arylsulfotransferase Ig-like domain ABC_tran PF00005.27 EMC79574.1 - 8.4e-30 104.1 0.0 1.2e-29 103.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EMC79574.1 - 5.7e-14 52.6 0.1 6.1e-09 36.1 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EMC79574.1 - 0.0014 18.1 0.1 1.1 8.7 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EMC79574.1 - 0.0036 17.8 2.5 0.0052 17.3 2.5 1.5 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 EMC79574.1 - 0.014 15.2 0.3 0.026 14.2 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 EMC79574.1 - 0.038 13.7 0.4 0.074 12.8 0.4 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF1846 PF08903.11 EMC79574.1 - 0.071 11.6 0.0 0.097 11.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1846) AAA_30 PF13604.6 EMC79574.1 - 0.075 12.7 0.0 0.13 12.0 0.0 1.5 1 1 0 1 1 1 0 AAA domain MukB PF04310.12 EMC79574.1 - 0.077 12.8 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 MukB N-terminal SRP54 PF00448.22 EMC79574.1 - 0.081 12.6 0.2 0.12 12.0 0.2 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_22 PF13401.6 EMC79574.1 - 0.12 12.7 0.4 0.48 10.7 0.4 2.1 1 1 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 EMC79574.1 - 0.13 12.5 0.0 2.3 8.5 0.0 2.4 1 1 1 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 EMC79574.1 - 0.18 12.2 0.0 0.27 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain VWC PF00093.18 EMC79576.1 - 4.4e-09 36.5 52.4 7.8e-06 26.1 17.1 3.2 3 0 0 3 3 3 3 von Willebrand factor type C domain Pacifastin_I PF05375.13 EMC79576.1 - 0.0016 18.1 5.1 0.0016 18.1 5.1 3.9 3 0 0 3 3 3 2 Pacifastin inhibitor (LCMII) Jnk-SapK_ap_N PF09744.9 EMC79577.1 - 0.41 10.9 10.4 0.86 9.8 10.4 1.5 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Cep57_CLD_2 PF14197.6 EMC79577.1 - 5 7.3 12.0 15 5.8 0.5 3.3 1 1 3 4 4 4 0 Centrosome localisation domain of PPC89 zf-H2C2_2 PF13465.6 EMC79578.1 - 5.4e-16 58.2 34.8 9.2e-08 32.2 2.7 7.5 7 0 0 7 7 7 3 Zinc-finger double domain zf-C2H2 PF00096.26 EMC79578.1 - 1.4e-15 56.8 43.1 8.1e-05 22.9 1.3 6.8 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC79578.1 - 2.9e-11 43.2 41.4 0.0009 19.9 1.1 6.9 6 0 0 6 6 6 4 C2H2-type zinc finger zf-H2C2_5 PF13909.6 EMC79578.1 - 5.8e-05 22.8 6.3 0.0005 19.8 1.3 5.2 5 0 0 5 5 5 2 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 EMC79578.1 - 0.0011 19.1 16.2 0.91 9.9 0.0 5.5 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding GAGA PF09237.11 EMC79578.1 - 0.0024 17.6 3.7 0.19 11.6 0.1 3.2 2 1 1 3 3 3 2 GAGA factor zf-MYND PF01753.18 EMC79578.1 - 0.12 12.5 10.0 0.24 11.5 0.0 3.6 3 1 0 3 3 3 0 MYND finger zf-met PF12874.7 EMC79578.1 - 0.29 11.6 0.2 0.29 11.6 0.2 6.3 6 0 0 6 6 6 0 Zinc-finger of C2H2 type DUF3268 PF11672.8 EMC79578.1 - 0.65 10.3 7.1 2.1 8.7 0.3 3.1 3 0 0 3 3 3 0 zinc-finger-containing domain zf-C2H2_8 PF15909.5 EMC79578.1 - 2.5 8.5 14.4 0.3 11.4 2.8 3.5 3 1 0 3 3 3 0 C2H2-type zinc ribbon CxC3 PF18804.1 EMC79578.1 - 2.7 7.9 5.1 8.9 6.2 0.0 3.4 2 1 1 3 3 3 0 CxC3 like cysteine cluster associated with KDZ transposases zf-C2HE PF16278.5 EMC79578.1 - 3.8 8.0 25.3 0.83 10.2 1.0 5.8 5 1 1 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger zf-TRAF PF02176.18 EMC79578.1 - 4.6 8.0 15.6 0.73 10.6 4.2 3.4 3 0 0 3 3 3 0 TRAF-type zinc finger zf-C2H2_11 PF16622.5 EMC79578.1 - 8 6.3 18.7 0.12 12.2 0.3 4.1 4 0 0 4 4 4 0 zinc-finger C2H2-type zinc_ribbon_15 PF17032.5 EMC79578.1 - 9.9 7.0 14.5 5.9 7.7 0.5 3.9 4 0 0 4 4 4 0 zinc-ribbon family Pkinase_Tyr PF07714.17 EMC79579.1 - 1.3e-91 306.5 0.0 2.4e-91 305.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.24 EMC79579.1 - 1.6e-58 195.7 4.0 1.1e-29 102.8 0.2 2.4 2 0 0 2 2 2 2 Receptor L domain GF_recep_IV PF14843.6 EMC79579.1 - 3.4e-53 179.0 82.1 3.4e-47 159.5 28.9 3.9 2 1 1 3 3 3 3 Growth factor receptor domain IV Pkinase PF00069.25 EMC79579.1 - 1.4e-39 136.1 0.0 2.2e-39 135.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.20 EMC79579.1 - 1.1e-35 122.7 88.1 1e-28 100.1 42.3 4.3 2 1 2 4 4 4 3 Furin-like cysteine rich region Haspin_kinase PF12330.8 EMC79579.1 - 0.0028 16.7 0.0 0.0047 15.9 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EMC79579.1 - 0.013 15.4 0.1 0.022 14.7 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EMC79579.1 - 0.022 14.1 0.0 0.046 13.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like DUF3951 PF13131.6 EMC79579.1 - 0.08 13.2 1.6 0.18 12.0 1.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3951) Adeno_E3_CR2 PF02439.15 EMC79579.1 - 0.25 11.1 2.1 0.67 9.8 2.1 1.7 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 CPSase_L_D2 PF02786.17 EMC79580.1 - 7e-114 378.6 0.7 4.5e-82 274.6 0.0 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 EMC79580.1 - 1.5e-37 128.7 0.0 4.6e-37 127.1 0.0 1.9 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain GATase PF00117.28 EMC79580.1 - 1.2e-36 126.2 0.0 2.3e-36 125.4 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.22 EMC79580.1 - 3e-28 98.2 0.0 7.4e-28 96.9 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain MGS PF02142.22 EMC79580.1 - 7.5e-19 67.7 0.0 1.3e-17 63.8 0.0 2.6 2 0 0 2 2 2 1 MGS-like domain ATP-grasp PF02222.22 EMC79580.1 - 8.6e-17 61.2 0.4 3.8e-08 33.1 0.1 2.4 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EMC79580.1 - 3e-13 49.8 0.6 2.1e-06 27.5 0.1 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 EMC79580.1 - 4.4e-12 45.9 0.0 1.7e-05 24.5 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 EMC79580.1 - 4.6e-05 23.5 0.1 0.03 14.4 0.1 2.6 2 0 0 2 2 2 2 ATP-grasp domain CPSase_C PF18302.1 EMC79580.1 - 0.0029 17.7 0.5 0.0079 16.3 0.5 1.8 1 0 0 1 1 1 1 Carbamoyl phosphate synthetase C-terminal domain LANC_like PF05147.13 EMC79581.1 - 3.4e-84 282.4 0.6 4.4e-84 282.1 0.6 1.1 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein EF-hand_6 PF13405.6 EMC79582.1 - 1.5e-11 43.3 0.9 0.00023 20.8 0.2 4.4 4 1 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 EMC79582.1 - 2.7e-11 43.8 0.1 5e-05 23.7 0.0 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EMC79582.1 - 3.3e-11 41.9 5.7 0.011 15.2 0.1 5.2 5 1 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 EMC79582.1 - 2.2e-06 27.4 1.7 0.082 12.8 0.1 3.3 2 2 2 4 4 4 2 EF-hand domain pair EF-hand_9 PF14658.6 EMC79582.1 - 0.00017 21.8 0.0 0.36 11.2 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain Cas9_REC PF16592.5 EMC79582.1 - 0.017 13.9 0.2 0.019 13.7 0.2 1.1 1 0 0 1 1 1 0 REC lobe of CRISPR-associated endonuclease Cas9 SapB_1 PF05184.15 EMC79582.1 - 0.12 12.4 0.0 18 5.5 0.0 2.4 2 0 0 2 2 2 0 Saposin-like type B, region 1 DUF2267 PF10025.9 EMC79582.1 - 0.13 12.5 0.3 0.57 10.5 0.3 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) Acyl-CoA_dh_1 PF00441.24 EMC79583.1 - 8e-42 143.0 0.1 1.2e-41 142.4 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EMC79583.1 - 2.3e-30 105.5 0.0 5.4e-30 104.4 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EMC79583.1 - 3.2e-25 88.1 0.0 7.1e-25 87.0 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EMC79583.1 - 6.7e-08 32.9 0.0 1.1e-07 32.3 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 EMC79583.1 - 0.033 14.7 0.0 0.079 13.5 0.0 1.7 1 0 0 1 1 1 0 Acyl-coenzyme A oxidase N-terminal PEHE PF15275.6 EMC79584.1 - 3.5e-23 82.6 5.4 3.5e-23 82.6 5.4 4.5 4 1 1 5 5 5 1 PEHE domain Mo-co_dimer PF03404.16 EMC79584.1 - 0.052 13.6 0.2 0.12 12.4 0.2 1.6 1 0 0 1 1 1 0 Mo-co oxidoreductase dimerisation domain Ribul_P_3_epim PF00834.19 EMC79585.1 - 1.8e-44 151.6 0.1 2e-44 151.4 0.1 1.0 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.19 EMC79585.1 - 0.0035 17.1 0.0 0.0051 16.6 0.0 1.3 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain OMPdecase PF00215.24 EMC79585.1 - 0.0056 16.3 0.0 0.008 15.8 0.0 1.3 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family TMP-TENI PF02581.17 EMC79585.1 - 0.0062 15.9 0.0 0.011 15.1 0.0 1.4 1 1 0 1 1 1 1 Thiamine monophosphate synthase His_biosynth PF00977.21 EMC79585.1 - 0.067 12.6 0.0 0.28 10.6 0.0 1.8 1 1 1 2 2 2 0 Histidine biosynthesis protein UNC80 PF15778.5 EMC79586.1 - 2.8e-90 301.0 0.0 3.6e-90 300.6 0.0 1.1 1 0 0 1 1 1 1 Cation channel complex component UNC80 Tubulin-binding PF00418.19 EMC79587.1 - 1.6e-63 210.4 21.3 9.9e-16 57.5 2.6 5.5 5 0 0 5 5 5 5 Tau and MAP protein, tubulin-binding repeat RII_binding_1 PF10522.9 EMC79587.1 - 0.0012 18.8 0.8 0.003 17.6 0.8 1.8 1 0 0 1 1 1 1 RII binding domain Nckap1 PF09735.9 EMC79588.1 - 0 1677.0 27.2 0 1676.8 27.2 1.0 1 0 0 1 1 1 1 Membrane-associated apoptosis protein Nup35_RRM PF05172.13 EMC79589.1 - 5.7e-27 93.6 0.1 9.5e-27 92.9 0.1 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 EMC79589.1 - 9.6e-12 44.7 0.0 1.4e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif zf-C2H2_jaz PF12171.8 EMC79590.1 - 7.9e-06 26.0 9.2 7.9e-06 26.0 9.2 2.7 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding BIR PF00653.21 EMC79591.1 - 6.7e-22 77.9 4.5 8.1e-22 77.7 4.5 1.1 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain zf-C3HC PF07967.13 EMC79591.1 - 0.0018 18.3 0.8 0.0019 18.3 0.8 1.1 1 0 0 1 1 1 1 C3HC zinc finger-like Castor1_N PF18700.1 EMC79591.1 - 0.04 13.8 0.0 0.062 13.1 0.0 1.3 1 0 0 1 1 1 0 Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain AAA_6 PF12774.7 EMC79592.1 - 1.9e-159 530.0 0.0 2.5e-157 523.0 0.0 3.1 4 0 0 4 4 4 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EMC79592.1 - 2.9e-143 477.8 6.5 2.9e-143 477.8 6.5 4.6 5 1 0 5 5 4 1 Dynein heavy chain, N-terminal region 2 Dynein_C PF18199.1 EMC79592.1 - 1.2e-121 405.6 0.0 5.9e-120 400.1 0.0 2.6 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_8 PF12780.7 EMC79592.1 - 1.7e-109 365.2 1.9 3e-106 354.5 0.1 2.9 3 0 0 3 3 2 2 P-loop containing dynein motor region D4 AAA_9 PF12781.7 EMC79592.1 - 1.1e-94 315.7 1.4 8.7e-93 309.5 0.6 3.7 3 0 0 3 3 3 1 ATP-binding dynein motor region AAA_7 PF12775.7 EMC79592.1 - 7.1e-83 276.6 0.1 9.3e-81 269.7 0.0 3.2 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_lid_11 PF18198.1 EMC79592.1 - 3.2e-62 209.2 0.2 2.4e-61 206.3 0.0 2.5 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain MT PF12777.7 EMC79592.1 - 4.7e-58 196.9 4.9 4.7e-58 196.9 4.9 2.5 3 0 0 3 3 3 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 EMC79592.1 - 3.4e-48 162.7 0.0 9.4e-45 151.6 0.0 2.9 2 0 0 2 2 2 2 Dynein heavy chain region D6 P-loop domain Dynein_AAA_lid PF17852.1 EMC79592.1 - 1.4e-37 128.6 0.1 1e-36 125.8 0.1 2.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 EMC79592.1 - 1e-20 74.1 0.0 0.00021 21.3 0.0 5.8 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 EMC79592.1 - 9.1e-18 64.3 0.2 1.7e-16 60.3 0.1 3.0 2 0 0 2 2 2 1 AAA+ lid domain AAA_22 PF13401.6 EMC79592.1 - 6e-07 29.8 1.2 0.084 13.1 0.0 5.0 4 0 0 4 4 4 1 AAA domain AAA PF00004.29 EMC79592.1 - 8.3e-06 26.3 3.5 1.8 9.0 0.0 5.7 6 0 0 6 6 5 2 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EMC79592.1 - 0.00067 20.2 0.1 0.071 13.7 0.0 4.1 4 0 0 4 4 2 1 AAA domain AAA_16 PF13191.6 EMC79592.1 - 0.0013 19.1 0.2 10 6.5 0.0 4.5 4 0 0 4 4 4 0 AAA ATPase domain RNA_helicase PF00910.22 EMC79592.1 - 0.0021 18.4 0.1 8.3 6.9 0.0 3.8 4 0 0 4 4 2 0 RNA helicase AAA_30 PF13604.6 EMC79592.1 - 0.0031 17.3 0.2 3.8 7.2 0.2 2.9 3 0 0 3 3 2 2 AAA domain EF-hand_1 PF00036.32 EMC79592.1 - 0.0038 16.7 1.5 0.019 14.5 1.5 2.3 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EMC79592.1 - 0.036 14.0 1.9 0.15 12.0 1.9 2.2 1 0 0 1 1 1 0 EF-hand domain AAA_24 PF13479.6 EMC79592.1 - 0.062 13.0 0.1 19 4.9 0.0 2.9 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 EMC79592.1 - 0.097 12.3 0.7 3.6 7.2 0.0 3.1 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain AAA_19 PF13245.6 EMC79592.1 - 0.12 12.7 0.5 30 4.9 0.0 3.9 4 0 0 4 4 4 0 AAA domain AAA_33 PF13671.6 EMC79592.1 - 0.14 12.3 0.0 3.7 7.7 0.0 2.9 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 EMC79592.1 - 0.16 11.7 2.6 11 5.7 0.0 3.8 4 0 0 4 4 3 0 Conserved hypothetical ATP binding protein T2SSE PF00437.20 EMC79592.1 - 0.17 10.9 0.8 0.67 9.0 0.0 2.4 3 0 0 3 3 2 0 Type II/IV secretion system protein DUF4407 PF14362.6 EMC79592.1 - 0.19 11.1 12.9 1.4 8.2 3.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4407) EF-hand_7 PF13499.6 EMC79592.1 - 0.94 10.0 5.4 0.73 10.3 1.6 2.9 2 0 0 2 2 1 0 EF-hand domain pair BLOC1S3 PF15753.5 EMC79592.1 - 3.6 7.7 7.5 0.74 9.9 0.3 2.8 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 Zip PF02535.22 EMC79594.1 - 2.4e-97 326.1 22.1 1.2e-65 221.9 13.0 5.2 2 2 3 5 5 5 2 ZIP Zinc transporter U1snRNP70_N PF12220.8 EMC79594.1 - 3.5 8.3 10.1 0.16 12.6 3.7 2.2 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Ost4 PF10215.9 EMC79594.1 - 9.5 6.1 6.9 9.6 6.1 2.3 2.7 2 0 0 2 2 2 0 Oligosaccaryltransferase Kazal_2 PF07648.15 EMC79595.1 - 7e-19 67.7 33.6 1.2e-10 41.3 7.8 4.6 4 0 0 4 4 4 2 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EMC79595.1 - 2.3e-13 49.9 19.7 4.5e-09 36.2 5.8 4.7 3 2 2 5 5 5 2 Kazal-type serine protease inhibitor domain EGF_2 PF07974.13 EMC79595.1 - 0.0012 19.2 9.0 0.0012 19.2 9.0 5.2 3 2 2 5 5 5 2 EGF-like domain EphA2_TM PF14575.6 EMC79595.1 - 0.52 11.2 2.0 0.61 11.0 0.3 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF4834 PF16118.5 EMC79595.1 - 1.3 10.0 2.9 2.4 9.2 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) PTRF_SDPR PF15237.6 EMC79596.1 - 5.1e-86 288.3 12.9 5.1e-86 288.3 12.9 2.1 2 1 0 2 2 2 1 PTRF/SDPR family YlbD_coat PF14071.6 EMC79596.1 - 0.0099 16.1 4.9 0.0099 16.1 4.9 2.3 3 0 0 3 3 3 1 Putative coat protein tRNA_anti-codon PF01336.25 EMC79597.1 - 0.0076 16.2 0.0 0.01 15.8 0.0 1.2 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Pkinase PF00069.25 EMC79598.1 - 1.7e-22 80.0 0.0 1.9e-22 79.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC79598.1 - 2.1e-17 63.2 0.1 2.3e-17 63.1 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMC79598.1 - 8.9e-05 21.9 0.0 9.1e-05 21.9 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EMC79598.1 - 0.0033 16.8 0.0 0.0038 16.6 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EMC79598.1 - 0.029 13.3 0.0 0.033 13.1 0.0 1.0 1 0 0 1 1 1 0 Haspin like kinase domain CLN3 PF02487.17 EMC79598.1 - 0.03 13.4 0.0 0.032 13.3 0.0 1.1 1 0 0 1 1 1 0 CLN3 protein Pkinase_fungal PF17667.1 EMC79598.1 - 0.039 12.7 0.0 0.055 12.2 0.0 1.3 1 1 0 1 1 1 0 Fungal protein kinase RIO1 PF01163.22 EMC79598.1 - 0.093 12.3 0.0 0.1 12.2 0.0 1.1 1 0 0 1 1 1 0 RIO1 family Pkinase PF00069.25 EMC79599.1 - 3.3e-56 190.6 0.0 4.1e-56 190.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC79599.1 - 1.1e-33 116.6 0.0 1.3e-33 116.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC79599.1 - 1.3e-07 31.3 0.0 3.9e-07 29.7 0.0 1.8 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 EMC79599.1 - 0.00019 20.9 0.0 0.0013 18.1 0.0 2.0 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMC79599.1 - 0.001 17.9 0.0 0.0016 17.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase CLN3 PF02487.17 EMC79599.1 - 0.16 11.0 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 CLN3 protein RIO1 PF01163.22 EMC79599.1 - 0.16 11.5 0.0 0.19 11.3 0.0 1.1 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.20 EMC79599.1 - 0.24 11.0 0.0 0.34 10.5 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Myosin_head PF00063.21 EMC79600.1 - 1.5e-267 889.3 3.7 2e-267 888.9 3.7 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EMC79600.1 - 3.4e-43 147.5 7.9 7.4e-43 146.4 1.6 2.8 3 0 0 3 3 3 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.27 EMC79600.1 - 2.5e-05 23.7 21.1 0.15 11.9 0.2 6.0 5 0 0 5 5 5 3 IQ calmodulin-binding motif AAA_16 PF13191.6 EMC79600.1 - 0.0077 16.6 0.0 0.029 14.7 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EMC79600.1 - 0.031 14.5 0.0 0.11 12.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain Hpr_kinase_C PF07475.12 EMC79600.1 - 0.043 13.4 0.9 2 7.9 0.0 2.6 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain Sigma54_activat PF00158.26 EMC79600.1 - 0.084 12.6 0.0 1 9.1 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain Chorismate_bind PF00425.18 EMC79600.1 - 0.11 12.1 0.0 15 5.0 0.0 2.4 2 0 0 2 2 2 0 chorismate binding enzyme DUF4441 PF14536.6 EMC79600.1 - 8.2 6.7 10.0 2.9 8.1 1.3 3.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4441) NEMP PF10225.9 EMC79601.1 - 3.6e-78 262.7 8.3 4.9e-78 262.3 8.3 1.2 1 0 0 1 1 1 1 NEMP family Kringle PF00051.18 EMC79601.1 - 0.52 10.7 3.4 6.8 7.1 0.0 2.8 2 1 0 2 2 2 0 Kringle domain MFS_1_like PF12832.7 EMC79602.1 - 8.8e-93 311.2 11.5 1.2e-92 310.8 11.5 1.2 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 EMC79602.1 - 5.3e-32 111.1 22.0 8.8e-17 61.1 11.6 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily Nuc_H_symport PF03825.16 EMC79602.1 - 1e-07 31.3 7.0 1e-07 31.3 7.0 3.6 3 1 0 3 3 3 1 Nucleoside H+ symporter LacY_symp PF01306.19 EMC79602.1 - 1.1e-06 27.7 18.3 0.0014 17.5 3.7 3.2 3 0 0 3 3 3 3 LacY proton/sugar symporter MFS_3 PF05977.13 EMC79602.1 - 0.00082 17.9 2.0 0.00096 17.7 0.7 1.7 2 0 0 2 2 2 1 Transmembrane secretion effector DUF5316 PF17247.2 EMC79602.1 - 0.057 13.4 0.0 0.22 11.6 0.0 2.0 1 0 0 1 1 1 0 Family of unknown function (DUF5316) OppC_N PF12911.7 EMC79602.1 - 2.7 8.1 12.4 4.6 7.3 0.2 4.1 4 0 0 4 4 4 0 N-terminal TM domain of oligopeptide transport permease C ECH_2 PF16113.5 EMC79603.1 - 1.4e-139 465.2 0.0 1.7e-139 465.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EMC79603.1 - 1.1e-33 116.6 0.0 1.1e-31 110.0 0.0 2.1 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Thioredox_DsbH PF03190.15 EMC79603.1 - 0.037 14.0 0.0 0.064 13.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF255 TGFb_propeptide PF00688.18 EMC79604.1 - 1.3e-33 116.8 0.0 1.6e-33 116.5 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 EMC79604.1 - 5.8e-19 69.0 0.8 1.6e-15 58.0 0.8 2.8 1 1 0 1 1 1 1 Transforming growth factor beta like domain LydB PF16084.5 EMC79604.1 - 0.08 12.8 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 LydA-holin antagonist ORMDL PF04061.14 EMC79605.1 - 2.8e-53 179.4 3.5 3.2e-53 179.2 3.5 1.0 1 0 0 1 1 1 1 ORMDL family Peptidase_M22 PF00814.25 EMC79606.1 - 1.1e-57 195.9 1.6 1.3e-57 195.6 1.6 1.0 1 0 0 1 1 1 1 Glycoprotease family Peptidase_S32 PF05579.13 EMC79606.1 - 0.018 14.2 0.1 0.028 13.6 0.1 1.2 1 0 0 1 1 1 0 Equine arteritis virus serine endopeptidase S32 Asn_synthase PF00733.21 EMC79607.1 - 8.2e-20 71.8 0.0 1.8e-08 34.4 0.0 3.3 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 EMC79607.1 - 4.9e-07 29.7 0.0 4.5e-06 26.6 0.0 2.5 1 1 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EMC79607.1 - 0.00026 21.2 0.0 0.00075 19.7 0.0 1.8 2 0 0 2 2 2 1 Glutamine amidotransferase domain ATP_bind_3 PF01171.20 EMC79607.1 - 0.018 14.8 0.0 0.04 13.7 0.0 1.5 1 0 0 1 1 1 0 PP-loop family QueC PF06508.13 EMC79607.1 - 0.097 12.1 0.0 0.22 11.0 0.0 1.6 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC NAD_synthase PF02540.17 EMC79607.1 - 0.15 11.1 0.2 0.7 9.0 0.1 1.9 1 1 1 2 2 2 0 NAD synthase FPN1 PF06963.12 EMC79608.1 - 3.9e-187 622.2 12.8 4.5e-187 622.0 12.8 1.0 1 0 0 1 1 1 1 Ferroportin1 (FPN1) MFS_1 PF07690.16 EMC79608.1 - 1.2e-06 27.8 30.3 9.4e-06 24.8 1.7 3.7 3 1 1 4 4 4 3 Major Facilitator Superfamily Vezatin PF12632.7 EMC79608.1 - 0.76 9.1 2.8 1.2 8.4 2.8 1.3 1 0 0 1 1 1 0 Mysoin-binding motif of peroxisomes WD40 PF00400.32 EMC79609.1 - 0.00028 21.6 1.1 7.8 7.6 0.4 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat TGF_beta PF00019.20 EMC79610.1 - 1.2e-31 109.7 0.1 1.8e-31 109.2 0.1 1.3 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 EMC79610.1 - 3e-22 79.6 0.0 4.2e-22 79.1 0.0 1.2 1 0 0 1 1 1 1 TGF-beta propeptide Ion_trans PF00520.31 EMC79611.1 - 2.2e-33 115.5 9.9 3.1e-33 115.0 9.9 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 EMC79611.1 - 3.1e-24 85.1 0.0 6.3e-24 84.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 EMC79611.1 - 9.9e-12 44.7 3.8 9.9e-12 44.7 3.8 2.2 2 0 0 2 2 2 1 Ion channel PKD_channel PF08016.12 EMC79611.1 - 0.083 11.6 8.3 0.26 9.9 8.3 1.8 1 1 0 1 1 1 0 Polycystin cation channel Ank_2 PF12796.7 EMC79612.1 - 1.9e-24 86.1 4.8 7.3e-14 52.1 0.7 2.2 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC79612.1 - 4.8e-23 81.2 4.9 7.2e-11 42.4 0.0 4.6 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC79612.1 - 1.2e-19 70.1 10.5 2.9e-10 40.2 0.2 4.8 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EMC79612.1 - 3.7e-19 68.3 6.0 4.3e-05 23.8 0.3 4.6 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EMC79612.1 - 5.9e-16 57.0 5.6 0.00044 20.5 0.0 5.1 5 0 0 5 5 5 3 Ankyrin repeat Nop14 PF04147.12 EMC79612.1 - 0.04 12.2 5.9 0.046 11.9 5.9 1.1 1 0 0 1 1 1 0 Nop14-like family zf-CHY PF05495.12 EMC79612.1 - 0.085 13.4 0.8 0.2 12.2 0.8 1.6 1 0 0 1 1 1 0 CHY zinc finger Raftlin PF15250.6 EMC79612.1 - 0.64 8.7 4.1 0.89 8.2 4.1 1.1 1 0 0 1 1 1 0 Raftlin SDA1 PF05285.12 EMC79612.1 - 0.79 9.1 10.7 1 8.7 10.7 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 EMC79612.1 - 3.2 5.9 7.3 4.4 5.5 7.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Fibrinogen_C PF00147.18 EMC79613.1 - 1.8e-62 211.0 0.9 1.9e-62 210.9 0.2 1.4 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain UPF0242 PF06785.11 EMC79613.1 - 0.15 12.1 6.6 0.24 11.5 6.6 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DivIC PF04977.15 EMC79613.1 - 0.34 10.7 6.3 0.63 9.8 6.3 1.3 1 0 0 1 1 1 0 Septum formation initiator Ras PF00071.22 EMC79614.1 - 5.7e-24 84.6 0.1 6.1e-24 84.5 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC79614.1 - 3e-18 66.2 0.1 3.2e-18 66.1 0.1 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC79614.1 - 0.00043 19.8 0.0 0.00046 19.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC79614.1 - 0.00064 19.8 0.1 0.00072 19.6 0.1 1.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase RINGv PF12906.7 EMC79617.1 - 3e-15 56.0 7.1 3e-15 56.0 7.1 2.8 4 0 0 4 4 4 1 RING-variant domain Vpu PF00558.19 EMC79617.1 - 0.011 15.5 0.2 0.02 14.7 0.2 1.3 1 0 0 1 1 1 0 Vpu protein zf-RING_2 PF13639.6 EMC79617.1 - 0.017 15.5 6.4 0.017 15.5 6.4 2.4 3 0 0 3 3 3 0 Ring finger domain zf-ANAPC11 PF12861.7 EMC79617.1 - 0.046 13.8 0.9 0.046 13.8 0.9 2.2 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 EMC79617.1 - 0.44 10.8 6.3 0.47 10.7 2.3 2.7 2 1 1 3 3 3 0 FANCL C-terminal domain PRY PF13765.6 EMC79619.1 - 2.3e-21 75.2 0.0 3.4e-21 74.6 0.0 1.3 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.28 EMC79619.1 - 2.1e-08 34.3 0.0 2.9e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 SPRY domain PRY PF13765.6 EMC79620.1 - 5.8e-19 67.5 0.0 1.2e-18 66.5 0.0 1.5 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.28 EMC79620.1 - 3.3e-07 30.4 0.0 4.2e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 SPRY domain Myelin_PLP PF01275.19 EMC79621.1 - 8.9e-63 212.3 14.8 1e-62 212.1 14.8 1.0 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) DUF2701 PF10857.8 EMC79621.1 - 0.077 13.0 2.7 0.2 11.7 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2701) EF-hand_1 PF00036.32 EMC79622.1 - 0.00088 18.7 0.7 0.00088 18.7 0.7 2.3 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.6 EMC79622.1 - 0.0025 17.6 0.5 0.0059 16.4 0.2 1.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 EMC79622.1 - 0.0083 15.6 0.4 0.02 14.4 0.4 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EMC79622.1 - 0.058 13.8 0.1 0.058 13.8 0.1 2.0 2 1 0 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.6 EMC79622.1 - 0.3 11.1 0.1 0.3 11.1 0.1 2.3 3 0 0 3 3 3 0 EF-hand domain IRK PF01007.20 EMC79623.1 - 1.1e-46 158.1 0.1 1.9e-46 157.4 0.1 1.4 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain IRK_C PF17655.1 EMC79623.1 - 2.2e-36 125.1 0.1 2.8e-36 124.7 0.1 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain Ion_trans_2 PF07885.16 EMC79623.1 - 0.00013 21.9 3.1 0.00028 20.8 3.1 1.6 1 1 0 1 1 1 1 Ion channel GYF PF02213.16 EMC79624.1 - 7.7e-22 76.7 0.7 1.7e-21 75.6 0.7 1.6 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 EMC79624.1 - 7.3e-07 28.9 0.1 2.9e-06 27.0 0.1 2.2 1 0 0 1 1 1 1 GYF domain 2 DUF4690 PF15756.5 EMC79625.1 - 1.2e-46 157.2 0.3 1.4e-46 157.1 0.3 1.0 1 0 0 1 1 1 1 Small Novel Rich in Cartilage RhoGEF PF00621.20 EMC79626.1 - 8.2e-35 120.7 7.9 1.4e-34 120.0 7.9 1.4 1 0 0 1 1 1 1 RhoGEF domain SH3_1 PF00018.28 EMC79626.1 - 2.3e-12 46.3 0.0 6.5e-12 44.9 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EMC79626.1 - 2.5e-12 46.5 0.1 5.1e-12 45.5 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC79626.1 - 2.8e-07 30.1 0.0 7e-07 28.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.29 EMC79626.1 - 7.1e-06 26.5 0.2 8.8e-05 23.0 0.0 2.7 3 0 0 3 3 3 1 PH domain SesA PF17107.5 EMC79626.1 - 0.014 15.6 0.6 0.044 14.0 0.6 1.8 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases SH3_16 PF18348.1 EMC79626.1 - 0.042 13.6 0.0 0.34 10.7 0.0 2.2 2 0 0 2 2 2 0 Bacterial dipeptidyl-peptidase Sh3 domain BNR_2 PF13088.6 EMC79627.1 - 3.3e-35 121.8 0.0 4.4e-35 121.3 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 EMC79627.1 - 0.018 15.0 4.8 0.22 11.6 0.1 3.7 4 0 0 4 4 4 0 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 EMC79627.1 - 0.083 11.7 0.0 1.7 7.4 0.0 2.1 2 0 0 2 2 2 0 Sortilin, neurotensin receptor 3, SH2 PF00017.24 EMC79628.1 - 5.5e-18 64.9 0.0 2e-17 63.0 0.0 2.1 1 0 0 1 1 1 1 SH2 domain Exo_endo_phos PF03372.23 EMC79628.1 - 8.4e-10 38.6 0.0 1.4e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family ATG16 PF08614.11 EMC79629.1 - 3.7e-38 131.8 27.6 3.7e-38 131.8 27.6 1.9 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) WD40 PF00400.32 EMC79629.1 - 4.8e-35 119.0 11.1 1.2e-06 29.1 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC79629.1 - 2.9e-09 37.1 0.1 0.016 15.5 0.0 4.8 1 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC79629.1 - 4.5e-06 26.7 0.0 0.32 10.9 0.0 3.5 2 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EMC79629.1 - 1.5e-05 24.2 0.1 0.4 9.6 0.2 3.4 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EMC79629.1 - 0.00012 20.9 7.5 1.5 7.4 0.0 4.6 3 1 1 5 5 5 3 Nucleoporin Nup120/160 ZapB PF06005.12 EMC79629.1 - 0.0039 17.6 7.2 0.0039 17.6 7.2 3.7 1 1 2 3 3 3 1 Cell division protein ZapB Fez1 PF06818.15 EMC79629.1 - 0.0042 17.6 26.4 0.0077 16.7 26.4 1.4 1 0 0 1 1 1 1 Fez1 KASH_CCD PF14662.6 EMC79629.1 - 0.016 15.0 13.1 0.016 15.0 13.1 2.8 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH ERM PF00769.19 EMC79629.1 - 0.033 14.0 32.0 0.019 14.8 29.9 1.5 1 1 0 1 1 1 0 Ezrin/radixin/moesin family SGL PF08450.12 EMC79629.1 - 0.039 13.5 0.0 0.15 11.6 0.0 1.9 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region V_ATPase_I PF01496.19 EMC79629.1 - 0.052 11.5 12.4 0.067 11.1 12.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HTH_6 PF01418.17 EMC79629.1 - 0.063 13.3 1.0 0.16 12.0 1.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family Lipoprotein_6 PF01441.19 EMC79629.1 - 0.067 13.2 4.8 0.12 12.3 4.4 1.6 1 1 0 1 1 1 0 Lipoprotein WD40_like PF17005.5 EMC79629.1 - 0.077 12.3 0.0 0.53 9.6 0.0 2.3 3 1 0 3 3 3 0 WD40-like domain YabA PF06156.13 EMC79629.1 - 0.28 11.8 20.4 0.19 12.4 7.7 2.6 1 1 1 2 2 2 0 Initiation control protein YabA YicC_N PF03755.13 EMC79629.1 - 0.56 10.7 9.0 1.1 9.7 9.0 1.5 1 0 0 1 1 1 0 YicC-like family, N-terminal region FUSC PF04632.12 EMC79629.1 - 1.5 7.3 11.2 2.1 6.8 11.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family NPV_P10 PF05531.12 EMC79629.1 - 1.5 9.3 5.1 0.74 10.3 0.7 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Lebercilin PF15619.6 EMC79629.1 - 1.7 8.3 34.8 3.2 7.4 34.8 1.4 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Atg14 PF10186.9 EMC79629.1 - 1.7 7.7 15.7 3.1 6.8 15.7 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Synaptobrevin PF00957.21 EMC79629.1 - 1.9 8.4 6.5 3 7.7 4.9 2.2 2 0 0 2 2 2 0 Synaptobrevin Phage_GPO PF05929.11 EMC79629.1 - 2.1 7.9 16.6 1.2 8.7 13.2 2.1 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF1664 PF07889.12 EMC79629.1 - 2.5 8.2 7.9 13 5.8 7.9 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) MRP-S27 PF10037.9 EMC79629.1 - 2.5 6.8 18.8 3.7 6.3 18.8 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 Allexi_40kDa PF05549.11 EMC79629.1 - 2.8 7.4 8.4 4 6.9 7.2 1.7 1 1 0 1 1 1 0 Allexivirus 40kDa protein DUF812 PF05667.11 EMC79629.1 - 3.5 6.4 27.6 4.8 5.9 27.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) TSC22 PF01166.18 EMC79629.1 - 4.3 7.7 8.9 1.4 9.3 1.8 3.0 1 1 2 3 3 3 0 TSC-22/dip/bun family FlaC_arch PF05377.11 EMC79629.1 - 5 7.6 8.9 0.25 11.8 1.6 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) PKcGMP_CC PF16808.5 EMC79629.1 - 5.7 6.9 11.8 0.31 10.9 2.2 3.4 2 1 1 3 3 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase APG6_N PF17675.1 EMC79629.1 - 6.8 7.2 40.3 6.1 7.4 23.2 3.0 1 1 2 3 3 3 0 Apg6 coiled-coil region Syntaxin-6_N PF09177.11 EMC79629.1 - 8.7 7.0 17.1 4.9 7.8 8.6 3.0 1 1 2 3 3 3 0 Syntaxin 6, N-terminal DUF724 PF05266.14 EMC79629.1 - 8.7 6.1 21.4 0.19 11.5 13.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) HALZ PF02183.18 EMC79629.1 - 9.2 6.6 13.3 0.35 11.1 5.0 3.1 2 2 1 3 3 2 0 Homeobox associated leucine zipper Arrestin_N PF00339.29 EMC79630.1 - 1.3e-38 132.3 0.3 2e-34 118.7 0.0 2.5 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EMC79630.1 - 5.2e-26 91.7 2.0 7.8e-26 91.1 2.0 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain DUF2079 PF09852.9 EMC79630.1 - 0.02 13.7 0.1 0.029 13.3 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2079) Transglut_C PF00927.22 EMC79630.1 - 0.023 14.8 0.4 0.053 13.7 0.4 1.6 1 0 0 1 1 1 0 Transglutaminase family, C-terminal ig like domain DAGK_acc PF00609.19 EMC79631.1 - 2.4e-51 174.2 0.0 4.8e-51 173.3 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 EMC79631.1 - 2.1e-27 95.2 0.1 5.5e-27 93.9 0.0 1.8 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain SAM_2 PF07647.17 EMC79631.1 - 3e-19 68.9 1.0 1.5e-18 66.7 0.2 2.4 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) C1_1 PF00130.22 EMC79631.1 - 1.2e-18 66.7 28.2 8.6e-11 41.6 4.9 2.9 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) SAM_1 PF00536.30 EMC79631.1 - 1.6e-17 63.6 2.6 9.1e-17 61.3 0.6 2.4 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PH PF00169.29 EMC79631.1 - 3.9e-15 56.3 1.4 6.7e-15 55.5 0.2 2.1 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 EMC79631.1 - 0.00011 22.4 0.2 0.00025 21.3 0.2 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EMC79631.1 - 0.0014 19.1 6.0 0.0028 18.0 2.5 3.3 2 1 0 2 2 2 1 Pleckstrin homology domain C1_2 PF03107.16 EMC79631.1 - 0.0021 18.3 16.0 0.014 15.7 5.7 2.8 2 0 0 2 2 2 2 C1 domain Mcp5_PH PF12814.7 EMC79631.1 - 0.0086 16.2 0.1 0.022 14.9 0.1 1.7 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology LIM PF00412.22 EMC79632.1 - 1.1e-61 204.9 59.5 1.5e-14 54.0 3.2 5.1 5 0 0 5 5 5 5 LIM domain zf-C4pol PF14260.6 EMC79632.1 - 3 8.4 0.0 3 8.4 0.0 7.1 2 2 4 6 6 6 0 C4-type zinc-finger of DNA polymerase delta zf-met PF12874.7 EMC79632.1 - 4.5 7.8 0.0 4.5 7.8 0.0 5.4 5 0 0 5 5 5 0 Zinc-finger of C2H2 type 7tm_1 PF00001.21 EMC79633.1 - 1.6e-49 168.6 17.6 1.6e-49 168.6 17.6 1.4 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC79633.1 - 4.8e-07 29.4 19.1 5.8e-07 29.2 19.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 EMC79633.1 - 0.00041 19.8 16.9 0.00041 19.8 16.9 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 EMC79633.1 - 0.0023 17.6 10.1 0.0023 17.6 10.1 2.4 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Srg PF02118.21 EMC79633.1 - 0.022 14.5 19.9 0.024 14.3 19.0 1.5 1 1 0 1 1 1 0 Srg family chemoreceptor 7tm_4 PF13853.6 EMC79633.1 - 0.026 14.3 16.8 1.2 8.8 16.8 2.5 1 1 0 1 1 1 0 Olfactory receptor DUF5409 PF17421.2 EMC79633.1 - 0.051 14.3 0.5 0.051 14.3 0.5 2.5 3 0 0 3 3 3 0 Family of unknown function (DUF5409) DUF373 PF04123.13 EMC79633.1 - 5.6 6.3 8.6 0.79 9.1 5.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF373) DUF2070 PF09843.9 EMC79633.1 - 9.8 4.3 18.6 6.6 4.9 16.6 1.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2070) Glycolytic PF00274.19 EMC79634.1 - 1.6e-07 30.4 0.1 1.7e-07 30.3 0.1 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I DUF2680 PF10925.8 EMC79634.1 - 0.07 13.1 0.0 0.082 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2680) p450 PF00067.22 EMC79635.1 - 1e-108 364.1 0.0 1.2e-108 363.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1819 PF08849.11 EMC79635.1 - 0.13 12.1 0.2 7.5 6.3 0.1 2.3 2 0 0 2 2 2 0 Putative inner membrane protein (DUF1819) Ldl_recept_a PF00057.18 EMC79637.1 - 3.9 7.8 7.2 85 3.5 0.2 3.3 3 0 0 3 3 3 0 Low-density lipoprotein receptor domain class A IGFBP PF00219.18 EMC79638.1 - 7.2 7.3 27.6 1.9 9.2 1.5 2.5 2 1 0 2 2 2 0 Insulin-like growth factor binding protein Syndecan PF01034.20 EMC79639.1 - 5.4e-27 93.5 0.0 9.6e-27 92.7 0.0 1.4 1 0 0 1 1 1 1 Syndecan domain Glycophorin_A PF01102.18 EMC79639.1 - 0.013 15.7 0.9 0.046 13.9 0.0 2.3 2 1 0 3 3 3 0 Glycophorin A PUF PF00806.19 EMC79640.1 - 3.5e-74 240.5 8.7 1.1e-09 37.5 0.0 8.4 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.11 EMC79640.1 - 0.023 15.1 1.2 5.8 7.3 0.1 3.9 1 1 3 4 4 4 0 CPL (NUC119) domain sCache_2 PF17200.4 EMC79640.1 - 0.031 14.1 0.2 53 3.6 0.0 4.1 4 0 0 4 4 4 0 Single Cache domain 2 Mt_ATP-synt_B PF05405.14 EMC79640.1 - 3.9 7.1 6.0 9.8 5.8 0.2 3.3 3 1 0 3 3 3 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) AA_permease_2 PF13520.6 EMC79641.1 - 5.8e-55 186.8 45.4 7.5e-55 186.5 45.4 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMC79641.1 - 7.1e-24 84.2 40.4 1.1e-23 83.6 40.4 1.2 1 0 0 1 1 1 1 Amino acid permease Ras PF00071.22 EMC79642.1 - 9.6e-58 194.4 0.0 1.2e-57 194.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC79642.1 - 4.4e-23 81.8 0.0 6.8e-23 81.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC79642.1 - 1e-10 41.4 0.0 1.8e-10 40.5 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC79642.1 - 0.00011 21.9 0.0 0.00021 20.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EMC79642.1 - 0.026 14.4 0.0 0.084 12.8 0.0 1.8 2 1 0 2 2 2 0 RsgA GTPase Gtr1_RagA PF04670.12 EMC79642.1 - 0.027 13.8 0.0 0.042 13.2 0.0 1.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EMC79642.1 - 0.098 12.1 0.0 0.15 11.5 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Hormone_3 PF00159.18 EMC79643.1 - 5.3e-19 68.0 1.1 1e-18 67.1 1.1 1.5 1 0 0 1 1 1 1 Pancreatic hormone peptide HEAT PF02985.22 EMC79644.1 - 2.2e-16 58.5 0.8 0.0099 16.1 0.0 6.7 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.6 EMC79644.1 - 8.2e-09 35.7 0.1 0.00054 20.3 0.0 3.8 2 1 1 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 EMC79644.1 - 0.00019 21.8 1.9 0.26 11.8 0.0 4.6 5 0 0 5 5 5 1 HEAT-like repeat Cnd1 PF12717.7 EMC79644.1 - 0.039 14.0 0.0 2.8 8.0 0.0 2.8 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.8 EMC79644.1 - 0.078 12.9 1.9 0.74 9.7 0.0 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF3385) Nuc_H_symport PF03825.16 EMC79644.1 - 0.11 11.5 0.1 4.9 6.0 0.0 2.3 2 0 0 2 2 2 0 Nucleoside H+ symporter TMF_TATA_bd PF12325.8 EMC79644.1 - 0.29 11.4 3.5 1.5 9.1 0.1 2.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DivIC PF04977.15 EMC79644.1 - 3.1 7.7 5.6 4.4 7.1 0.2 2.6 2 0 0 2 2 2 0 Septum formation initiator PigN PF04987.14 EMC79645.1 - 5.8e-138 460.6 49.6 7.7e-138 460.2 49.6 1.2 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 EMC79645.1 - 2.6e-14 53.6 0.2 1.4e-12 47.9 0.2 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 EMC79645.1 - 4.2e-06 26.3 0.0 8.1e-06 25.4 0.0 1.5 1 1 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 EMC79645.1 - 8.9e-05 22.0 0.0 0.00021 20.8 0.0 1.6 2 0 0 2 2 2 1 Sulfatase Orthoreo_P10 PF07204.11 EMC79645.1 - 0.02 14.8 1.8 1 9.3 0.1 2.6 2 0 0 2 2 2 0 Orthoreovirus membrane fusion protein p10 zf-RING_5 PF14634.6 EMC79646.1 - 1e-07 31.7 11.6 1e-07 31.7 11.6 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EMC79646.1 - 4.5e-07 29.6 12.7 8.6e-07 28.7 12.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC79646.1 - 8.9e-07 29.2 13.1 2e-06 28.0 13.1 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EMC79646.1 - 2.1e-05 24.4 10.7 4.5e-05 23.4 10.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 EMC79646.1 - 8e-05 22.3 4.2 0.068 12.9 0.1 2.6 2 0 0 2 2 2 2 RING-like zinc finger zf-C3HC4_2 PF13923.6 EMC79646.1 - 0.00059 19.6 12.9 0.0013 18.5 12.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMC79646.1 - 0.0023 18.0 11.7 0.0023 18.0 11.7 1.9 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EMC79646.1 - 0.0069 16.2 8.5 0.021 14.7 8.5 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 VMA21 PF09446.10 EMC79646.1 - 0.053 13.6 0.1 0.12 12.5 0.1 1.5 1 0 0 1 1 1 0 VMA21-like domain zf-RING_10 PF16685.5 EMC79646.1 - 0.067 13.3 8.6 0.12 12.5 8.6 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_4 PF14570.6 EMC79646.1 - 1.7 8.5 13.5 6.8 6.6 13.5 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Cadherin PF00028.17 EMC79647.1 - 3.4e-82 271.0 2.2 2.1e-18 66.6 0.0 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 EMC79647.1 - 6.1e-52 175.8 0.2 1.3e-51 174.7 0.2 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_3 PF16184.5 EMC79647.1 - 7.3e-07 29.2 4.3 0.34 10.9 0.0 4.9 5 0 0 5 5 5 2 Cadherin-like Cadherin_2 PF08266.12 EMC79647.1 - 8e-06 25.6 0.0 0.44 10.4 0.0 4.4 4 0 0 4 4 4 2 Cadherin-like Cadherin_4 PF17803.1 EMC79647.1 - 0.11 13.1 15.0 0.3 11.7 0.4 4.5 4 1 0 4 4 4 0 Bacterial cadherin-like domain Invasin_D3 PF09134.10 EMC79647.1 - 0.57 10.5 3.6 46 4.4 0.0 4.1 6 0 0 6 6 6 0 Invasin, domain 3 Cadherin PF00028.17 EMC79648.1 - 6.3e-81 266.9 5.4 6.6e-20 71.4 0.1 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 EMC79648.1 - 2e-57 193.6 0.3 3.8e-57 192.7 0.3 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_3 PF16184.5 EMC79648.1 - 7.2e-06 26.0 7.1 0.024 14.6 0.1 5.3 6 0 0 6 6 6 1 Cadherin-like Cadherin_2 PF08266.12 EMC79648.1 - 0.00038 20.2 0.0 1.7 8.5 0.0 4.2 4 1 0 4 4 4 1 Cadherin-like Invasin_D3 PF09134.10 EMC79648.1 - 0.0071 16.6 2.0 5.3 7.4 0.1 4.2 4 0 0 4 4 4 1 Invasin, domain 3 Cadherin_pro PF08758.11 EMC79648.1 - 0.064 13.4 0.0 4.7 7.4 0.0 3.3 3 0 0 3 3 3 0 Cadherin prodomain like ASFV_J13L PF05568.11 EMC79648.1 - 0.068 12.9 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 African swine fever virus J13L protein Big_9 PF17963.1 EMC79648.1 - 0.13 13.0 10.3 19 6.1 2.2 4.6 4 0 0 4 4 4 0 Bacterial Ig domain Stevor PF17410.2 EMC79648.1 - 0.18 11.3 0.1 0.3 10.6 0.1 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Cadherin_4 PF17803.1 EMC79648.1 - 0.5 11.0 15.4 0.84 10.3 3.5 4.5 4 1 0 4 4 4 0 Bacterial cadherin-like domain Yae1_N PF09811.9 EMC79649.1 - 4e-11 42.4 40.8 0.00068 19.3 6.5 5.1 2 1 3 5 5 5 5 Essential protein Yae1, N terminal RVT_1 PF00078.27 EMC79651.1 - 0.0012 18.4 0.0 0.0019 17.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) tRNA-synt_2c PF01411.19 EMC79652.1 - 3.1e-207 689.5 0.0 2.9e-173 577.3 0.0 2.3 1 1 1 2 2 2 2 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EMC79652.1 - 5.6e-17 61.6 0.1 1.3e-16 60.3 0.1 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 EMC79652.1 - 2.3e-16 60.5 0.4 2.3e-16 60.5 0.4 2.1 2 0 0 2 2 2 1 DHHA1 domain Syntaxin-6_N PF09177.11 EMC79652.1 - 0.015 15.8 1.5 0.045 14.3 1.5 1.8 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Med11 PF10280.9 EMC79652.1 - 0.064 13.7 0.1 0.19 12.2 0.0 1.8 2 0 0 2 2 2 0 Mediator complex protein Asp-B-Hydro_N PF05279.11 EMC79652.1 - 0.083 12.9 3.2 0.17 12.0 3.2 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Lipase_GDSL_3 PF14606.6 EMC79652.1 - 0.11 12.6 0.1 0.25 11.4 0.1 1.5 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family DUF4404 PF14357.6 EMC79652.1 - 2.5 8.8 4.3 4.2 8.1 1.7 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4404) adh_short PF00106.25 EMC79653.1 - 7.3e-31 107.1 0.0 1.4e-30 106.2 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC79653.1 - 2e-20 73.4 0.0 4.8e-20 72.1 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC79653.1 - 1e-08 35.3 0.0 2.2e-08 34.2 0.0 1.4 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.6 EMC79653.1 - 0.0053 16.7 0.0 0.34 10.8 0.0 2.2 2 0 0 2 2 2 1 NAD(P)H-binding adh_short PF00106.25 EMC79654.1 - 2.6e-32 111.9 0.0 5.4e-32 110.8 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC79654.1 - 9.4e-23 81.0 0.0 1.4e-22 80.4 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC79654.1 - 3.9e-10 39.9 0.0 6.9e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 KR domain NmrA PF05368.13 EMC79654.1 - 0.0031 17.1 0.0 0.0045 16.6 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family zf-H2C2_2 PF13465.6 EMC79656.1 - 1.1e-50 167.8 95.0 1e-08 35.2 0.6 11.3 11 0 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.26 EMC79656.1 - 7.6e-34 114.3 102.2 8.8e-05 22.8 1.1 11.3 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC79656.1 - 5e-26 89.1 96.8 0.0048 17.6 2.7 11.3 11 0 0 11 11 11 10 C2H2-type zinc finger zf-H2C2_5 PF13909.6 EMC79656.1 - 1.5e-16 59.8 87.6 1.1e-06 28.3 0.6 10.6 11 0 0 11 11 11 5 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 EMC79656.1 - 8.2e-10 38.7 58.3 0.042 14.1 0.1 11.1 11 0 0 11 11 11 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC79656.1 - 0.006 16.9 1.3 0.006 16.9 1.3 9.7 11 0 0 11 11 10 4 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EMC79656.1 - 0.021 14.8 1.6 0.021 14.8 1.6 11.0 11 2 0 11 11 10 0 C2H2-type zinc finger zf_UBZ PF18439.1 EMC79656.1 - 1.3 8.6 0.0 1.3 8.6 0.0 6.9 8 1 0 8 8 8 0 Ubiquitin-Binding Zinc Finger GAGA PF09237.11 EMC79656.1 - 1.5 8.7 30.9 3.6 7.5 0.1 8.0 1 1 9 10 10 10 0 GAGA factor zf-C2H2_2 PF12756.7 EMC79656.1 - 3 8.2 61.8 2.4 8.5 7.0 7.6 1 1 4 6 6 6 0 C2H2 type zinc-finger (2 copies) TFIIF_alpha PF05793.12 EMC79656.1 - 5.5 5.5 24.7 0.069 11.7 13.2 2.3 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) zinc_ribbon_15 PF17032.5 EMC79656.1 - 6.4 7.6 43.9 5.3 7.9 0.9 6.0 2 1 4 6 6 6 0 zinc-ribbon family HEAT_2 PF13646.6 EMC79657.1 - 6.3e-06 26.5 3.6 3.1e-05 24.3 0.2 2.5 1 1 1 2 2 2 1 HEAT repeats PL48 PF15903.5 EMC79658.1 - 3.5e-172 572.1 0.1 4.1e-172 571.9 0.1 1.0 1 0 0 1 1 1 1 Filopodia upregulated, FAM65 HR1 PF02185.16 EMC79658.1 - 1.4e-06 28.3 0.4 6e-06 26.3 0.0 2.2 1 1 0 2 2 2 1 Hr1 repeat Uds1 PF15456.6 EMC79658.1 - 0.0099 16.0 1.0 0.014 15.6 0.1 1.7 2 0 0 2 2 2 1 Up-regulated During Septation FAM92 PF06730.11 EMC79658.1 - 0.11 11.9 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 FAM92 protein adh_short PF00106.25 EMC79659.1 - 3e-28 98.6 0.0 4.8e-28 97.9 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC79659.1 - 3e-20 72.8 0.0 4.5e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC79659.1 - 4.1e-06 26.8 0.0 6.2e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EMC79659.1 - 0.023 14.6 0.0 0.059 13.3 0.0 1.6 2 0 0 2 2 2 0 NAD(P)H-binding adh_short PF00106.25 EMC79660.1 - 3.9e-31 108.1 0.0 8.2e-31 107.0 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC79660.1 - 5.7e-22 78.4 0.0 1.2e-21 77.4 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC79660.1 - 4.7e-11 42.9 0.0 7.2e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 KR domain NmrA PF05368.13 EMC79660.1 - 0.0021 17.6 0.0 0.0058 16.2 0.0 1.7 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 EMC79660.1 - 0.11 12.3 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H-binding LCAT PF02450.15 EMC79661.1 - 6.8e-121 404.1 2.4 3.2e-120 401.9 2.4 1.8 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF915 PF06028.11 EMC79661.1 - 4.4e-05 22.9 0.0 0.00071 19.0 0.0 2.2 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_6 PF12697.7 EMC79661.1 - 0.00012 22.7 0.0 0.00018 22.2 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMC79661.1 - 0.00027 20.3 0.0 0.00075 18.8 0.0 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF1749 PF08538.10 EMC79661.1 - 0.0018 17.4 0.0 0.0029 16.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) PGAP1 PF07819.13 EMC79661.1 - 0.0043 16.8 0.1 0.019 14.7 0.0 2.0 3 0 0 3 3 3 1 PGAP1-like protein Abhydrolase_1 PF00561.20 EMC79661.1 - 0.0075 15.9 0.0 0.71 9.5 0.0 2.4 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF676 PF05057.14 EMC79661.1 - 0.032 13.7 0.0 0.058 12.9 0.0 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) DUF900 PF05990.12 EMC79661.1 - 0.045 13.3 0.0 0.084 12.4 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) DUF1704 PF08014.11 EMC79662.1 - 1e-12 47.8 0.1 2.1e-12 46.8 0.1 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF1704) TMEM208_SND2 PF05620.11 EMC79663.1 - 2.7e-44 150.9 0.0 3.9e-44 150.4 0.0 1.1 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 DUF3361 PF11841.8 EMC79664.1 - 2.8e-55 186.5 7.6 3.9e-55 186.0 5.9 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3361) ELMO_CED12 PF04727.13 EMC79664.1 - 1e-42 146.2 0.4 2.2e-42 145.2 0.4 1.6 1 0 0 1 1 1 1 ELMO/CED-12 family PH_12 PF16457.5 EMC79664.1 - 3.3e-35 121.5 0.0 6.8e-35 120.5 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain DegT_DnrJ_EryC1 PF01041.17 EMC79664.1 - 0.069 12.4 0.3 0.1 11.9 0.3 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family ZFYVE21_C PF16696.5 EMC79664.1 - 0.082 12.8 0.0 0.28 11.1 0.0 1.9 1 0 0 1 1 1 0 Zinc finger FYVE domain-containing protein 21 C-terminus E2F_CC-MB PF16421.5 EMC79665.1 - 9.4e-25 86.8 0.0 1.7e-24 86.0 0.0 1.4 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.20 EMC79665.1 - 2.3e-14 53.2 0.2 4.6e-14 52.2 0.2 1.5 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain Sec6 PF06046.13 EMC79666.1 - 2.9e-116 389.2 0.4 4.2e-116 388.6 0.4 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec6 Sec8_exocyst PF04048.14 EMC79666.1 - 0.029 14.3 0.4 0.2 11.5 0.2 2.4 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain SOAR PF16533.5 EMC79666.1 - 0.14 12.1 3.2 4.3 7.4 0.1 3.6 3 0 0 3 3 3 0 STIM1 Orai1-activating region Pkinase PF00069.25 EMC79668.1 - 1.8e-75 253.7 0.0 2.3e-75 253.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC79668.1 - 1.3e-35 123.0 0.0 1.7e-35 122.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC79668.1 - 2.4e-07 30.3 0.1 8.5e-06 25.3 0.0 2.3 2 1 1 3 3 3 1 Kinase-like FTA2 PF13095.6 EMC79668.1 - 0.00094 18.9 0.1 0.46 10.1 0.1 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EMC79668.1 - 0.001 18.5 0.0 0.002 17.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMC79668.1 - 0.0016 18.4 0.1 0.43 10.5 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Cytokin-bind PF09265.10 EMC79668.1 - 0.1 12.0 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding TmoB PF06234.12 EMC79668.1 - 0.14 12.3 0.0 0.66 10.1 0.0 2.2 3 0 0 3 3 3 0 Toluene-4-monooxygenase system protein B (TmoB) Ge1_WD40 PF16529.5 EMC79669.1 - 1.2e-140 468.1 0.0 2.1e-140 467.3 0.0 1.4 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40 PF00400.32 EMC79669.1 - 0.00031 21.5 3.3 0.0064 17.3 0.1 3.5 3 0 0 3 3 3 1 WD domain, G-beta repeat DUF445 PF04286.12 EMC79669.1 - 0.18 11.5 18.6 0.41 10.4 5.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF445) TetR_C_11 PF16859.5 EMC79669.1 - 2.7 8.3 4.5 2.7 8.3 0.6 2.6 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain PIN_8 PF18476.1 EMC79669.1 - 6.2 6.6 16.0 11 5.8 4.6 3.1 1 1 2 3 3 3 0 PIN like domain NTF2 PF02136.20 EMC79670.1 - 6.1e-34 117.2 0.0 6.8e-34 117.0 0.0 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4440 PF14534.6 EMC79670.1 - 0.048 14.1 0.0 0.059 13.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) CENP-T_C PF15511.6 EMC79671.1 - 4.9e-29 100.6 0.1 5.9e-29 100.4 0.1 1.1 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EMC79671.1 - 1.4e-08 35.0 0.0 1.8e-08 34.6 0.0 1.3 1 1 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EMC79671.1 - 0.00063 20.0 0.0 0.0009 19.5 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.13 EMC79671.1 - 0.0013 18.7 0.0 0.0021 18.1 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated Histone PF00125.24 EMC79671.1 - 0.015 15.7 0.1 0.018 15.4 0.1 1.2 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 EMC79671.1 - 0.12 12.4 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Amdo_NSP PF12475.8 EMC79671.1 - 0.12 12.4 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Amdovirus non-structural protein IL8 PF00048.20 EMC79672.1 - 8.4e-16 57.9 0.7 1e-15 57.6 0.7 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like IL8 PF00048.20 EMC79673.1 - 8.2e-16 57.9 0.0 9.7e-16 57.7 0.0 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like IL8 PF00048.20 EMC79675.1 - 0.02 15.0 1.0 0.028 14.6 1.0 1.3 1 0 0 1 1 1 0 Small cytokines (intecrine/chemokine), interleukin-8 like MARVEL PF01284.23 EMC79676.1 - 7.3e-16 58.5 23.2 8.8e-16 58.2 23.2 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF805 PF05656.14 EMC79676.1 - 2.9 8.3 8.6 4.4 7.8 8.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF805) ARL2_Bind_BART PF11527.8 EMC79677.1 - 1.7e-33 115.2 8.7 2e-33 114.9 8.7 1.1 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART SF3A3 PF16837.5 EMC79677.1 - 0.63 10.6 4.9 2.5 8.7 0.1 2.9 2 2 1 3 3 3 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 Nefa_Nip30_N PF10187.9 EMC79678.1 - 1.7e-31 108.7 23.1 3.2e-31 107.8 23.1 1.5 1 0 0 1 1 1 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 Herpes_UL92 PF03048.14 EMC79678.1 - 0.099 12.4 0.2 0.16 11.8 0.2 1.2 1 0 0 1 1 1 0 UL92 family Copine PF07002.16 EMC79679.1 - 7.2e-88 293.7 0.0 1.1e-87 293.0 0.0 1.3 1 0 0 1 1 1 1 Copine C2 PF00168.30 EMC79679.1 - 8.8e-27 93.4 0.0 1.8e-13 50.6 0.0 2.4 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 EMC79679.1 - 9.3e-06 25.9 0.0 2.1e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 vWA found in TerF C terminus NACHT PF05729.12 EMC79680.1 - 7.2e-36 123.6 0.1 1.9e-35 122.3 0.1 1.8 1 0 0 1 1 1 1 NACHT domain Atypical_Card PF18461.1 EMC79680.1 - 1.7e-35 121.1 0.5 5.3e-34 116.3 0.0 3.2 2 0 0 2 2 2 1 Atypical caspase recruitment domain LRR_6 PF13516.6 EMC79680.1 - 1.7e-30 102.4 42.1 0.00079 19.3 0.3 16.7 17 0 0 17 17 16 7 Leucine Rich repeat NLRC4_HD2 PF17776.1 EMC79680.1 - 1.5e-20 74.0 5.7 5.5e-20 72.2 5.7 2.1 1 0 0 1 1 1 1 NLRC4 helical domain HD2 LRR_4 PF12799.7 EMC79680.1 - 4.2e-11 42.9 50.4 0.0087 16.5 0.2 13.0 12 3 0 12 12 12 4 Leucine Rich repeats (2 copies) NOD2_WH PF17779.1 EMC79680.1 - 1.9e-07 31.3 0.0 8e-07 29.3 0.0 2.2 1 0 0 1 1 1 1 NOD2 winged helix domain AAA PF00004.29 EMC79680.1 - 4.3e-06 27.2 0.0 1.1e-05 25.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) LRR_8 PF13855.6 EMC79680.1 - 0.00099 18.8 41.6 0.091 12.5 0.7 11.6 11 5 0 11 11 11 2 Leucine rich repeat AAA_16 PF13191.6 EMC79680.1 - 0.0076 16.6 0.1 0.036 14.5 0.0 2.2 2 0 0 2 2 1 1 AAA ATPase domain AAA_33 PF13671.6 EMC79680.1 - 0.017 15.3 0.1 0.047 13.8 0.1 1.8 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EMC79680.1 - 0.019 14.2 0.0 0.067 12.4 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain Mg_chelatase PF01078.21 EMC79680.1 - 0.025 14.0 0.0 0.052 12.9 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 EMC79680.1 - 0.05 13.9 0.0 0.6 10.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EMC79680.1 - 0.056 13.2 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain EbsA PF17255.2 EMC79680.1 - 0.058 13.7 0.3 0.56 10.5 0.1 2.4 2 0 0 2 2 2 0 EbsA-like protein AAA_7 PF12775.7 EMC79680.1 - 0.11 12.0 0.0 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EMC79680.1 - 0.13 12.6 0.0 0.38 11.2 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_25 PF13481.6 EMC79680.1 - 0.15 11.6 0.0 0.97 9.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain LBP_BPI_CETP_C PF02886.17 EMC79681.1 - 8e-29 100.8 0.6 8e-29 100.8 0.6 1.8 2 0 0 2 2 2 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 EMC79681.1 - 5.6e-27 94.4 0.6 3.9e-26 91.6 0.1 2.3 2 1 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain ubiquitin PF00240.23 EMC79682.1 - 1.6e-07 31.0 0.0 2.5e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 EMC79682.1 - 0.0029 18.1 0.0 0.011 16.3 0.0 1.9 1 1 0 1 1 1 1 DUF2407 ubiquitin-like domain Pex14_N PF04695.13 EMC79682.1 - 1.8 9.2 7.4 12 6.5 7.5 2.2 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PB1 PF00564.24 EMC79683.1 - 1e-12 47.8 0.2 2.2e-12 46.7 0.0 1.6 2 0 0 2 2 2 1 PB1 domain PDZ PF00595.24 EMC79683.1 - 2e-11 44.1 0.3 4.4e-11 43.0 0.2 1.6 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 EMC79683.1 - 1.2e-07 31.4 0.1 3.4e-07 30.0 0.1 1.7 2 0 0 2 2 2 1 PDZ domain GFO_IDH_MocA PF01408.22 EMC79684.1 - 6.7e-15 56.0 0.0 2.2e-14 54.3 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold F420_oxidored PF03807.17 EMC79684.1 - 0.0012 19.4 0.0 0.0032 18.0 0.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent GFO_IDH_MocA_C PF02894.17 EMC79684.1 - 0.0068 16.4 0.1 0.013 15.5 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Shikimate_DH PF01488.20 EMC79684.1 - 0.13 12.3 0.0 0.35 10.9 0.0 1.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Terminase_5 PF06056.12 EMC79685.1 - 0.027 14.3 0.4 0.027 14.3 0.4 2.2 1 1 1 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) Presenilin PF01080.17 EMC79685.1 - 8.9 5.0 7.7 10 4.8 7.7 1.1 1 0 0 1 1 1 0 Presenilin CIAPIN1 PF05093.13 EMC79686.1 - 4.4e-22 78.5 18.7 5.5e-17 62.1 4.6 2.8 2 1 1 3 3 3 2 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Methyltransf_11 PF08241.12 EMC79686.1 - 4.6e-06 27.2 0.0 9.1e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC79686.1 - 3.5e-05 23.6 0.0 7.2e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC79686.1 - 0.0012 18.7 0.0 0.0018 18.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC79686.1 - 0.0014 19.3 0.0 0.0028 18.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC79686.1 - 0.0047 17.6 0.0 0.0091 16.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 EMC79686.1 - 0.18 11.1 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Tat PF00539.18 EMC79686.1 - 6.7 6.9 13.4 0.11 12.6 1.9 2.4 1 1 1 2 2 2 0 Transactivating regulatory protein (Tat) COQ9 PF08511.11 EMC79687.1 - 1.2e-35 121.1 0.5 2.1e-35 120.3 0.5 1.4 1 0 0 1 1 1 1 COQ9 BicD PF09730.9 EMC79687.1 - 0.0049 15.4 0.5 0.0075 14.8 0.5 1.2 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D RNA_pol_A_bac PF01000.26 EMC79688.1 - 2.6e-40 137.3 0.0 3.6e-40 136.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EMC79688.1 - 4e-12 45.4 0.0 5.6e-12 44.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain IRS PF02174.17 EMC79689.1 - 2.8e-30 104.2 0.0 4.4e-30 103.5 0.0 1.3 1 0 0 1 1 1 1 PTB domain (IRS-1 type) Cytochrome_cB PF11783.8 EMC79689.1 - 0.087 12.7 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Cytochrome c bacterial PH PF00169.29 EMC79689.1 - 0.11 13.0 0.1 0.22 12.0 0.1 1.5 1 0 0 1 1 1 0 PH domain Myosin_tail_1 PF01576.19 EMC79690.1 - 2.6e-14 52.1 41.7 2.6e-14 52.1 41.7 3.0 2 1 1 3 3 3 3 Myosin tail Filament PF00038.21 EMC79690.1 - 0.0003 20.5 60.7 0.066 12.8 1.0 3.8 2 1 1 3 3 3 3 Intermediate filament protein PRKG1_interact PF15898.5 EMC79690.1 - 0.0025 18.7 12.9 0.0025 18.7 12.9 5.7 3 3 3 6 6 6 1 cGMP-dependent protein kinase interacting domain THOC7 PF05615.13 EMC79690.1 - 0.011 16.0 16.3 0.011 16.0 16.3 5.4 2 1 3 5 5 5 0 Tho complex subunit 7 Taxilin PF09728.9 EMC79690.1 - 0.045 12.9 67.6 1.7 7.8 9.4 4.0 2 1 1 3 3 3 0 Myosin-like coiled-coil protein Spc7 PF08317.11 EMC79690.1 - 0.085 11.7 68.5 0.049 12.5 21.4 4.2 2 1 2 4 4 4 0 Spc7 kinetochore protein BRE1 PF08647.11 EMC79690.1 - 0.13 12.3 57.4 0.48 10.5 0.9 5.0 2 1 3 5 5 5 0 BRE1 E3 ubiquitin ligase NPV_P10 PF05531.12 EMC79690.1 - 0.17 12.4 21.4 0.73 10.3 1.1 5.5 2 1 3 5 5 5 0 Nucleopolyhedrovirus P10 protein CRISPR_Cas2 PF09827.9 EMC79690.1 - 0.17 12.1 2.1 0.47 10.7 0.3 2.7 2 0 0 2 2 1 0 CRISPR associated protein Cas2 APG6_N PF17675.1 EMC79690.1 - 0.28 11.7 79.5 0.62 10.6 25.8 5.2 2 2 1 4 4 4 0 Apg6 coiled-coil region Leu_zip PF15294.6 EMC79690.1 - 0.61 9.6 49.3 0.027 14.0 26.9 3.1 2 1 1 3 3 3 0 Leucine zipper DUF3450 PF11932.8 EMC79690.1 - 0.66 9.2 53.6 0.06 12.6 2.3 4.6 2 1 3 5 5 5 0 Protein of unknown function (DUF3450) FlaC_arch PF05377.11 EMC79690.1 - 1.5 9.3 29.0 7 7.1 0.6 6.4 6 0 0 6 6 6 0 Flagella accessory protein C (FlaC) ADIP PF11559.8 EMC79690.1 - 1.6 8.8 60.5 1.3 9.1 11.1 5.0 2 1 3 5 5 5 0 Afadin- and alpha -actinin-Binding EzrA PF06160.12 EMC79690.1 - 3 5.9 46.6 0.6 8.2 4.4 4.0 2 1 1 3 3 3 0 Septation ring formation regulator, EzrA Fez1 PF06818.15 EMC79690.1 - 3.3 8.1 66.4 2.9 8.3 24.3 3.9 1 1 2 3 3 3 0 Fez1 DUF4407 PF14362.6 EMC79690.1 - 4.9 6.4 44.0 2.7 7.3 2.3 3.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) Laminin_II PF06009.12 EMC79690.1 - 5.9 6.9 30.0 0.81 9.7 9.2 4.7 2 1 3 5 5 5 0 Laminin Domain II DUF1664 PF07889.12 EMC79690.1 - 8.7 6.4 30.8 8.1 6.5 7.6 5.2 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) DUF4201 PF13870.6 EMC79690.1 - 8.8 6.0 63.7 1 9.1 2.7 4.5 2 1 1 4 4 4 0 Domain of unknown function (DUF4201) PLL PF18587.1 EMC79691.1 - 1.4e-49 167.7 0.4 3.2e-49 166.5 0.4 1.7 1 0 0 1 1 1 1 PTX/LNS-Like (PLL) domain 7tm_2 PF00002.24 EMC79691.1 - 1.8e-29 102.7 19.4 2.9e-29 102.1 19.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 EMC79691.1 - 3.3e-13 49.9 4.0 3.3e-13 49.9 4.0 2.1 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif 7tm_2 PF00002.24 EMC79692.1 - 3e-33 115.1 25.1 4.1e-33 114.7 25.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 EMC79692.1 - 1.6e-14 54.2 3.5 4.1e-14 52.8 3.5 1.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Gp5_C PF06715.12 EMC79692.1 - 2.8 8.3 4.8 1.5 9.1 0.4 2.5 2 0 0 2 2 2 0 Gp5 C-terminal repeat (3 copies) Transglut_core PF01841.19 EMC79693.1 - 0.00082 19.8 0.0 0.0029 18.1 0.0 2.0 1 1 0 1 1 1 1 Transglutaminase-like superfamily DUF553 PF04473.12 EMC79693.1 - 0.072 12.6 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 Transglutaminase-like domain DUF5487 PF17589.2 EMC79693.1 - 0.16 12.2 0.2 16 5.8 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5487) Katanin_con80 PF13925.6 EMC79694.1 - 3.6e-52 176.6 1.3 5.3e-52 176.1 1.3 1.3 1 0 0 1 1 1 1 con80 domain of Katanin WD40 PF00400.32 EMC79694.1 - 8.4e-50 165.7 7.4 1.2e-11 45.0 0.2 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC79694.1 - 4.3e-20 71.8 0.0 8.9e-05 22.7 0.0 5.7 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC79694.1 - 1.1e-06 28.7 0.0 0.00092 19.1 0.0 2.8 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EMC79694.1 - 0.0029 16.3 1.0 12 4.4 0.0 4.2 4 1 0 5 5 5 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EMC79694.1 - 0.0045 16.0 0.0 0.38 9.7 0.0 3.1 1 1 2 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 EMC79694.1 - 0.066 11.9 0.1 2.3 6.8 0.1 3.3 2 1 1 3 3 3 0 Nup133 N terminal like ALS_ss_C PF10369.9 EMC79694.1 - 0.2 11.9 0.0 11 6.3 0.0 2.8 2 0 0 2 2 2 0 Small subunit of acetolactate synthase Kinesin PF00225.23 EMC79695.1 - 1.3e-107 359.6 0.0 1.5e-107 359.4 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EMC79695.1 - 4.4e-44 150.0 0.0 6.7e-44 149.4 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding Enolase_C PF00113.22 EMC79695.1 - 0.15 11.3 0.0 0.21 10.8 0.0 1.1 1 0 0 1 1 1 0 Enolase, C-terminal TIM barrel domain CusF_Ec PF11604.8 EMC79695.1 - 0.21 11.6 0.1 0.5 10.4 0.1 1.5 1 0 0 1 1 1 0 Copper binding periplasmic protein CusF CENP-F_leu_zip PF10473.9 EMC79696.1 - 0.00044 20.3 17.1 0.00058 19.9 17.1 1.3 1 1 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 V_ATPase_I PF01496.19 EMC79696.1 - 0.00069 17.7 1.1 0.00075 17.6 1.1 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Filament PF00038.21 EMC79696.1 - 0.0027 17.4 11.2 0.0034 17.0 11.2 1.1 1 0 0 1 1 1 1 Intermediate filament protein Atg14 PF10186.9 EMC79696.1 - 0.0033 16.6 7.4 0.0041 16.2 7.4 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 EMC79696.1 - 0.0036 16.2 10.9 0.0046 15.9 10.9 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein AAA_13 PF13166.6 EMC79696.1 - 0.015 14.0 3.9 0.017 13.8 3.9 1.1 1 0 0 1 1 1 0 AAA domain FapA PF03961.13 EMC79696.1 - 0.02 13.5 6.1 0.023 13.3 6.1 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A GRA6 PF05084.13 EMC79696.1 - 0.081 12.9 1.6 0.1 12.5 1.6 1.1 1 0 0 1 1 1 0 Granule antigen protein (GRA6) PRKG1_interact PF15898.5 EMC79696.1 - 0.086 13.7 16.4 0.15 13.0 12.9 2.5 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain Rho_Binding PF08912.11 EMC79696.1 - 0.11 13.3 1.1 0.11 13.3 1.1 2.9 3 0 0 3 3 3 0 Rho Binding Macoilin PF09726.9 EMC79696.1 - 0.13 10.8 10.5 0.13 10.8 10.5 1.1 1 0 0 1 1 1 0 Macoilin family GAS PF13851.6 EMC79696.1 - 0.25 10.7 15.2 3.1 7.1 5.2 2.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding FAM76 PF16046.5 EMC79696.1 - 0.35 10.2 4.7 0.42 9.9 4.7 1.1 1 0 0 1 1 1 0 FAM76 protein DUF3450 PF11932.8 EMC79696.1 - 0.36 10.1 15.1 0.17 11.2 10.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) APG6_N PF17675.1 EMC79696.1 - 0.41 11.2 19.0 0.64 10.6 18.9 1.4 1 1 0 1 1 1 0 Apg6 coiled-coil region Exonuc_VII_L PF02601.15 EMC79696.1 - 0.53 9.8 7.6 0.61 9.6 7.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit UPF0242 PF06785.11 EMC79696.1 - 0.89 9.6 15.0 2.4 8.2 5.9 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus COG2 PF06148.11 EMC79696.1 - 1.2 9.2 9.1 0.7 10.0 5.9 2.1 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Fmp27_WPPW PF10359.9 EMC79696.1 - 1.6 7.5 7.9 2 7.2 7.9 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain FemAB PF02388.16 EMC79696.1 - 2.3 7.0 5.9 3 6.6 5.9 1.1 1 0 0 1 1 1 0 FemAB family TMPIT PF07851.13 EMC79696.1 - 3 7.0 6.7 4.1 6.5 6.7 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF2203 PF09969.9 EMC79696.1 - 4.4 8.1 8.1 3.9 8.2 5.5 1.9 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) ZapB PF06005.12 EMC79696.1 - 4.5 7.8 21.3 4.4 7.8 11.1 2.9 2 1 1 3 3 3 0 Cell division protein ZapB DUF5339 PF17274.2 EMC79696.1 - 5.3 8.0 11.8 0.51 11.2 0.4 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5339) FUSC PF04632.12 EMC79696.1 - 5.6 5.4 8.0 6 5.3 8.0 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family cNMP_binding PF00027.29 EMC79697.1 - 1.9e-17 63.1 0.0 4.2e-17 62.0 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain zf-C2H2 PF00096.26 EMC79701.1 - 9e-59 192.8 148.6 2.6e-06 27.5 0.9 17.3 17 0 0 17 17 17 16 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC79701.1 - 1.9e-54 179.7 142.2 4.1e-11 42.8 1.4 17.7 18 0 0 18 18 18 13 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC79701.1 - 5.1e-40 132.7 133.9 0.0013 19.4 2.1 17.1 17 0 0 17 17 17 15 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC79701.1 - 1.3e-26 92.3 84.2 0.0012 19.1 0.1 15.0 15 0 0 15 15 15 10 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC79701.1 - 3.3e-17 62.2 92.6 0.016 15.6 0.6 14.9 15 0 0 15 15 14 9 Zinc-finger of C2H2 type BolA PF01722.18 EMC79701.1 - 2.9e-06 27.5 36.0 0.34 11.2 0.2 8.8 3 2 5 10 10 10 4 BolA-like protein zf-C2H2_6 PF13912.6 EMC79701.1 - 0.00012 22.0 1.8 0.00012 22.0 1.8 17.1 17 1 0 17 17 17 8 C2H2-type zinc finger MRP-S23 PF10484.9 EMC79701.1 - 0.014 15.7 0.1 75 3.6 0.0 5.0 3 2 2 5 5 5 0 Mitochondrial ribosomal protein S23 DUF2712 PF10916.8 EMC79701.1 - 0.1 13.3 0.0 0.36 11.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2712) Antimicrobial_3 PF08025.11 EMC79701.1 - 0.18 11.8 1.0 39 4.3 0.1 4.0 3 0 0 3 3 3 0 Spider antimicrobial peptide zf_PR_Knuckle PF18445.1 EMC79701.1 - 0.88 9.4 23.8 8.1 6.4 0.3 8.0 8 0 0 8 8 7 0 PR zinc knuckle motif UPF0728 PF15092.6 EMC79701.1 - 2.3 8.1 8.8 3.8 7.4 0.1 4.7 4 1 0 4 4 4 0 Uncharacterised protein family UPF0728 Ta0938 PF11494.8 EMC79701.1 - 5.4 7.4 21.2 8.2 6.8 1.8 7.0 2 2 7 9 9 9 0 Ta0938 zf-Di19 PF05605.12 EMC79701.1 - 7 7.0 106.9 0.41 11.0 9.8 11.3 5 3 9 14 14 14 0 Drought induced 19 protein (Di19), zinc-binding HVSL PF09749.9 EMC79702.1 - 4.9e-44 150.6 0.0 5.3e-44 150.5 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein Peptidase_M10 PF00413.24 EMC79703.1 - 7.1e-43 146.2 0.1 8.9e-43 145.9 0.1 1.1 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 EMC79703.1 - 2.1e-12 46.8 4.4 3.7e-07 30.0 0.4 2.8 2 0 0 2 2 2 2 Hemopexin DUF4953 PF16313.5 EMC79703.1 - 0.012 14.9 0.1 0.016 14.5 0.1 1.1 1 0 0 1 1 1 0 Met-zincin Metallopep PF12044.8 EMC79703.1 - 0.019 13.6 0.0 0.025 13.2 0.0 1.1 1 0 0 1 1 1 0 Putative peptidase family Reprolysin_5 PF13688.6 EMC79703.1 - 0.026 14.7 0.1 0.034 14.3 0.1 1.1 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EMC79703.1 - 0.028 14.9 0.3 0.04 14.5 0.3 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M54 PF07998.11 EMC79703.1 - 0.029 14.3 0.0 0.076 13.0 0.0 1.6 2 0 0 2 2 2 0 Peptidase family M54 Peptidase_M66 PF10462.9 EMC79703.1 - 0.054 12.4 0.0 0.081 11.9 0.0 1.2 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_4 PF13583.6 EMC79703.1 - 0.13 11.9 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.8 EMC79703.1 - 0.26 10.9 0.0 0.36 10.4 0.0 1.1 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase DUF667 PF05018.13 EMC79704.1 - 1.1e-79 266.4 0.8 1.3e-79 266.3 0.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF667) Pkinase PF00069.25 EMC79706.1 - 6.7e-71 238.7 0.9 7.9e-71 238.5 0.9 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC79706.1 - 7.8e-21 74.5 0.2 1.5e-20 73.6 0.1 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EMC79706.1 - 6.1e-10 39.4 0.0 1.4e-06 28.5 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EMC79706.1 - 0.00069 18.5 0.1 0.0062 15.4 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EMC79706.1 - 0.0051 16.2 0.4 0.0087 15.4 0.4 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EMC79706.1 - 0.0059 16.2 0.2 0.013 15.1 0.2 1.6 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kinase-like PF14531.6 EMC79706.1 - 0.039 13.3 0.7 0.14 11.5 0.1 2.1 2 1 0 2 2 2 0 Kinase-like PAS_3 PF08447.12 EMC79706.1 - 0.076 13.3 0.1 0.23 11.8 0.1 1.8 1 0 0 1 1 1 0 PAS fold ABC1 PF03109.16 EMC79706.1 - 0.1 12.8 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 ABC1 family DUF4201 PF13870.6 EMC79707.1 - 4.1e-34 117.8 31.4 9.8e-34 116.6 25.7 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) TEA PF01285.18 EMC79707.1 - 0.028 14.5 0.2 0.088 12.9 0.2 1.9 1 0 0 1 1 1 0 TEA/ATTS domain NFRKB_winged PF14465.6 EMC79707.1 - 0.23 11.7 6.0 0.72 10.1 0.5 3.0 3 1 1 4 4 4 0 NFRKB Winged Helix-like DUF1474 PF07342.11 EMC79707.1 - 0.46 11.0 3.7 1 10.0 0.9 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1474) APG6_N PF17675.1 EMC79707.1 - 1.3 9.6 30.9 3.4 8.2 1.1 3.5 2 1 0 2 2 2 0 Apg6 coiled-coil region DUF948 PF06103.11 EMC79707.1 - 5 7.5 10.1 0.7 10.2 0.8 3.1 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Fez1 PF06818.15 EMC79707.1 - 5.3 7.4 31.8 1.3 9.4 21.1 2.3 1 1 1 2 2 2 0 Fez1 EIF4E-T PF10477.9 EMC79707.1 - 8 5.2 14.4 19 3.9 14.4 1.6 1 1 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Ndr PF03096.14 EMC79708.1 - 6.9e-104 346.5 0.0 8e-104 346.3 0.0 1.0 1 0 0 1 1 1 1 Ndr family Abhydrolase_1 PF00561.20 EMC79708.1 - 0.02 14.5 0.1 0.04 13.5 0.1 1.4 1 1 0 1 1 1 0 alpha/beta hydrolase fold UCR_TM PF02921.14 EMC79709.1 - 2.8e-27 95.0 2.5 4.1e-27 94.5 2.5 1.3 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region Rieske PF00355.26 EMC79709.1 - 3.9e-13 49.1 0.1 1.1e-12 47.7 0.1 1.8 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain MCM_bind PF09739.9 EMC79709.1 - 0.093 11.2 0.0 0.12 10.8 0.0 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Isochorismatase PF00857.20 EMC79709.1 - 0.093 12.9 0.1 2.5 8.2 0.1 2.1 1 1 0 1 1 1 0 Isochorismatase family V-set PF07686.17 EMC79710.1 - 0.00013 22.1 0.0 0.00016 21.8 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.16 EMC79710.1 - 0.0045 17.0 0.0 0.0055 16.7 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC79710.1 - 0.032 14.8 0.0 0.037 14.6 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin domain ig PF00047.25 EMC79710.1 - 0.11 12.6 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin domain UPF0086 PF01868.16 EMC79711.1 - 4.5e-26 90.6 0.6 6.6e-26 90.1 0.1 1.5 2 0 0 2 2 2 1 Domain of unknown function UPF0086 FYVE PF01363.21 EMC79712.1 - 6.2e-18 64.7 7.1 1.2e-17 63.8 7.1 1.5 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 EMC79712.1 - 3.1e-09 37.3 0.4 6.1e-09 36.3 0.2 1.6 2 0 0 2 2 2 1 PH domain PH_13 PF16652.5 EMC79712.1 - 0.00013 21.8 0.6 0.0038 17.1 0.6 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 EMC79712.1 - 0.00056 19.9 0.1 0.0011 19.0 0.1 1.4 1 0 0 1 1 1 1 PH domain FYVE_2 PF02318.16 EMC79712.1 - 0.0089 16.2 8.7 0.014 15.6 8.5 1.5 1 1 0 1 1 1 1 FYVE-type zinc finger C1_2 PF03107.16 EMC79712.1 - 0.032 14.5 3.9 0.053 13.9 2.2 2.1 2 0 0 2 2 2 0 C1 domain DUF1835 PF08874.10 EMC79712.1 - 0.036 14.3 0.0 0.074 13.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1835) PH_6 PF15406.6 EMC79712.1 - 0.037 14.3 0.0 0.068 13.5 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain tRNA_bind_3 PF17176.4 EMC79712.1 - 0.095 13.0 0.1 0.17 12.2 0.1 1.4 1 0 0 1 1 1 0 tRNA-binding domain OrfB_Zn_ribbon PF07282.11 EMC79712.1 - 1.7 8.6 6.8 3.9 7.5 6.8 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-RING_4 PF14570.6 EMC79712.1 - 4 7.3 8.6 42 4.0 0.0 2.7 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-C2H2 PF00096.26 EMC79715.1 - 6.6e-08 32.6 14.2 0.13 12.7 0.0 3.9 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC79715.1 - 1.4e-05 25.5 13.9 0.11 13.3 0.1 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC79715.1 - 0.00044 20.5 0.0 0.00044 20.5 0.0 3.3 4 0 0 4 4 4 1 Zinc-finger double domain Zn-C2H2_12 PF18112.1 EMC79715.1 - 0.005 17.3 0.0 0.66 10.5 0.0 2.6 2 0 0 2 2 2 1 Autophagy receptor zinc finger-C2H2 domain DUF4764 PF15961.5 EMC79715.1 - 0.007 15.1 0.3 0.0087 14.8 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4764) zf-C2H2_11 PF16622.5 EMC79715.1 - 0.01 15.6 13.2 0.76 9.6 0.0 3.6 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2_aberr PF17017.5 EMC79715.1 - 0.17 12.0 2.0 3 7.9 0.0 2.4 1 1 1 2 2 2 0 Aberrant zinc-finger zf-C2H2_8 PF15909.5 EMC79715.1 - 0.25 11.6 3.5 3.3 8.1 0.3 2.4 1 1 3 4 4 4 0 C2H2-type zinc ribbon PH PF00169.29 EMC79716.1 - 3e-18 66.3 5.7 7.3e-18 65.0 0.1 3.6 3 0 0 3 3 3 1 PH domain PH_11 PF15413.6 EMC79716.1 - 0.00052 20.4 5.3 0.014 15.9 5.3 3.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 EMC79716.1 - 0.0029 17.7 0.0 0.0076 16.3 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 EMC79716.1 - 0.054 13.9 0.2 1.1 9.6 0.2 2.8 1 1 0 1 1 1 0 Pleckstrin homology domain PH_8 PF15409.6 EMC79716.1 - 0.086 13.1 0.0 0.25 11.6 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain PI-PLC-X PF00388.19 EMC79717.1 - 3e-62 208.5 0.0 5.1e-62 207.7 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EMC79717.1 - 4.8e-43 146.2 0.2 9.5e-43 145.2 0.2 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.11 EMC79717.1 - 1.1e-20 73.9 0.1 2.6e-20 72.7 0.1 1.7 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.30 EMC79717.1 - 3.7e-16 59.3 0.0 1.4e-15 57.4 0.0 2.0 1 0 0 1 1 1 1 C2 domain EF-hand_7 PF13499.6 EMC79717.1 - 0.035 14.5 0.2 0.27 11.7 0.2 2.4 2 1 0 2 2 2 0 EF-hand domain pair PT PF04886.12 EMC79721.1 - 0.00078 18.9 6.7 0.053 13.1 4.4 3.6 2 1 0 2 2 2 1 PT repeat EamA PF00892.20 EMC79723.1 - 2e-13 50.7 17.7 7.7e-09 35.8 3.0 2.5 2 1 0 2 2 2 2 EamA-like transporter family SLC35F PF06027.12 EMC79723.1 - 9.6e-12 45.0 2.2 9.6e-12 45.0 2.2 2.0 2 0 0 2 2 2 1 Solute carrier family 35 TPT PF03151.16 EMC79723.1 - 1.5e-09 37.6 1.4 3.2e-09 36.5 1.4 1.5 1 1 0 1 1 1 1 Triose-phosphate Transporter family Nuc_sug_transp PF04142.15 EMC79723.1 - 1.4e-08 34.3 0.0 2e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter CRT-like PF08627.10 EMC79723.1 - 4.4e-07 29.2 9.0 8.2e-07 28.3 3.4 2.0 1 1 1 2 2 2 2 CRT-like, chloroquine-resistance transporter-like Bax1-I PF01027.20 EMC79723.1 - 3.7e-05 23.7 1.9 3.7e-05 23.7 1.9 2.4 1 1 1 2 2 2 1 Inhibitor of apoptosis-promoting Bax1 UAA PF08449.11 EMC79723.1 - 0.00014 21.2 1.7 0.00019 20.7 1.7 1.2 1 0 0 1 1 1 1 UAA transporter family PUNUT PF16913.5 EMC79723.1 - 0.0004 19.7 0.1 0.00069 18.9 0.1 1.3 1 0 0 1 1 1 1 Purine nucleobase transmembrane transport Mg_trans_NIPA PF05653.14 EMC79723.1 - 0.0009 18.4 1.5 0.0019 17.4 1.5 1.5 1 0 0 1 1 1 1 Magnesium transporter NIPA TMEM234 PF10639.9 EMC79723.1 - 0.84 9.7 6.0 2.7 8.0 1.3 2.4 2 0 0 2 2 2 0 Putative transmembrane family 234 Integrase_H2C2 PF17921.1 EMC79725.1 - 3.5e-07 30.2 0.1 5.1e-07 29.7 0.1 1.2 1 0 0 1 1 1 1 Integrase zinc binding domain NFACT-R_1 PF05670.13 EMC79727.1 - 4.9e-43 146.2 0.1 5.8e-43 146.0 0.1 1.0 1 0 0 1 1 1 1 NFACT protein RNA binding domain YscJ_FliF PF01514.17 EMC79727.1 - 0.1 12.2 0.0 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 Secretory protein of YscJ/FliF family Acetyltransf_13 PF13880.6 EMC79728.1 - 1.6e-29 101.7 0.0 2.8e-29 100.9 0.0 1.4 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 EMC79728.1 - 6.2e-14 51.5 1.7 7.6e-14 51.3 0.7 1.7 2 0 0 2 2 2 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_7 PF13508.7 EMC79728.1 - 0.12 12.8 0.0 0.32 11.4 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Pkinase PF00069.25 EMC79729.1 - 7.3e-38 130.4 0.0 9.6e-38 130.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC79729.1 - 2.5e-32 112.2 0.0 3.6e-32 111.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EMC79729.1 - 0.093 12.3 0.0 0.13 11.8 0.0 1.3 1 1 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 EMC79729.1 - 0.097 11.4 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase DUF4226 PF10774.9 EMC79730.1 - 0.43 10.9 2.4 15 5.9 0.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4226) CFEM PF05730.11 EMC79730.1 - 5.2 7.3 11.6 8.2 6.6 9.2 2.2 2 0 0 2 2 2 0 CFEM domain Neur_chan_memb PF02932.16 EMC79731.1 - 2.6e-101 338.7 0.0 3.4e-101 338.3 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 EMC79731.1 - 7.5e-79 264.2 3.6 1.2e-78 263.5 3.6 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain PTPRCAP PF15713.5 EMC79731.1 - 0.0016 18.7 6.7 0.0026 18.0 6.7 1.2 1 0 0 1 1 1 1 Protein tyrosine phosphatase receptor type C-associated eIF3_subunit PF08597.10 EMC79731.1 - 0.053 13.4 4.6 0.097 12.6 4.6 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit PBP1_TM PF14812.6 EMC79731.1 - 0.35 11.3 1.6 0.85 10.0 1.6 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DNA_pol_phi PF04931.13 EMC79731.1 - 1.1 7.3 2.6 1.4 7.0 2.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi MHC_I PF00129.18 EMC79731.1 - 8.3 5.9 7.1 0.36 10.4 1.4 1.6 2 0 0 2 2 2 0 Class I Histocompatibility antigen, domains alpha 1 and 2 7tm_1 PF00001.21 EMC79732.1 - 6.4e-40 137.1 21.7 6.4e-40 137.1 21.7 1.7 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC79732.1 - 8.1e-07 28.7 22.9 1.1e-06 28.2 22.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC79732.1 - 0.0016 18.2 18.5 0.011 15.5 4.2 2.1 2 0 0 2 2 2 2 Olfactory receptor DUF5527 PF17665.1 EMC79732.1 - 0.019 14.5 0.1 0.045 13.3 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5527) DUF3899 PF13038.6 EMC79732.1 - 2.2 8.8 0.0 2.2 8.8 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3899) DUF3675 PF12428.8 EMC79732.1 - 3.3 8.3 9.0 18 5.9 5.9 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3675) DUF2208 PF09973.9 EMC79732.1 - 7.7 6.1 11.6 1.1 8.8 0.2 2.7 2 1 1 3 3 3 0 Predicted membrane protein (DUF2208) Keratin_B2 PF01500.17 EMC79733.1 - 2.1 8.3 42.4 0.25 11.3 8.1 3.7 1 1 2 3 3 3 0 Keratin, high sulfur B2 protein DNMT1-RFD PF12047.8 EMC79734.1 - 2.8e-47 160.4 0.0 7.3e-47 159.0 0.0 1.7 1 0 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain BAH PF01426.18 EMC79734.1 - 2.8e-46 156.3 0.0 5.4e-22 77.9 0.1 2.4 2 0 0 2 2 2 2 BAH domain DNA_methylase PF00145.17 EMC79734.1 - 4.8e-35 121.5 0.0 6.6e-19 68.4 0.0 2.3 2 0 0 2 2 2 2 C-5 cytosine-specific DNA methylase zf-CXXC PF02008.20 EMC79734.1 - 4.8e-15 55.3 21.2 1.8e-14 53.5 21.2 2.1 1 0 0 1 1 1 1 CXXC zinc finger domain DUF2284 PF10050.9 EMC79734.1 - 0.036 13.8 2.4 9.6 5.9 2.6 2.5 2 0 0 2 2 2 0 Predicted metal-binding protein (DUF2284) Laminin_G_2 PF02210.24 EMC79735.1 - 0.00082 20.0 0.0 0.0014 19.2 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 EMC79735.1 - 0.06 13.6 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Laminin G domain OLF PF02191.16 EMC79736.1 - 1.7e-84 283.3 3.3 2.2e-84 282.9 3.3 1.1 1 0 0 1 1 1 1 Olfactomedin-like domain Noelin-1 PF12308.8 EMC79736.1 - 3.8e-47 158.4 4.2 4.6e-46 154.9 0.9 3.0 3 0 0 3 3 3 1 Neurogenesis glycoprotein Atg8 PF02991.16 EMC79737.1 - 1.6e-34 118.2 0.1 1.8e-34 118.0 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EMC79737.1 - 2.9e-05 24.4 0.0 3.4e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Lectin_C PF00059.21 EMC79738.1 - 8.8e-24 84.3 5.4 9.6e-24 84.2 5.4 1.0 1 0 0 1 1 1 1 Lectin C-type domain LIM PF00412.22 EMC79740.1 - 1.5e-30 105.2 22.6 2.8e-16 59.5 6.4 2.3 2 0 0 2 2 2 2 LIM domain Homeodomain PF00046.29 EMC79740.1 - 3.7e-18 65.1 3.0 7.4e-18 64.1 2.7 1.7 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 EMC79740.1 - 0.00012 21.9 0.6 0.00038 20.3 0.2 2.2 2 0 0 2 2 2 1 Homeobox KN domain CX9C PF16860.5 EMC79741.1 - 7.1e-21 74.0 1.5 7.4e-15 54.7 0.0 2.1 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 EMC79741.1 - 1.3e-06 28.4 4.7 0.00014 21.9 0.7 2.4 2 0 0 2 2 2 2 CHCH domain Cmc1 PF08583.10 EMC79741.1 - 0.00023 21.1 5.9 0.5 10.4 0.1 3.0 1 1 2 3 3 3 3 Cytochrome c oxidase biogenesis protein Cmc1 like GCK PF07802.11 EMC79741.1 - 0.00092 19.6 3.4 0.15 12.5 0.5 2.2 1 1 1 2 2 2 2 GCK domain NDUF_B7 PF05676.13 EMC79741.1 - 0.0046 16.6 1.0 0.0046 16.6 1.0 2.2 1 1 0 2 2 2 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Pet191_N PF10203.9 EMC79741.1 - 0.041 14.2 5.6 0.19 12.0 3.1 2.3 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 UPF0203 PF05254.12 EMC79741.1 - 0.064 13.5 2.8 2.9 8.2 0.1 2.6 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) DD_K PF12121.8 EMC79741.1 - 0.087 13.0 1.2 0.15 12.2 1.2 1.4 1 0 0 1 1 1 0 Dermaseptin COX17 PF05051.13 EMC79741.1 - 0.11 12.9 3.2 5.4 7.5 0.4 2.8 2 1 1 3 3 3 0 Cytochrome C oxidase copper chaperone (COX17) E1-E2_ATPase PF00122.20 EMC79742.1 - 0.028 14.0 0.1 0.074 12.6 0.0 1.7 2 0 0 2 2 2 0 E1-E2 ATPase DUF2464 PF10240.9 EMC79743.1 - 8e-06 25.6 0.1 2.1e-05 24.2 0.0 1.6 2 0 0 2 2 2 1 Multivesicular body subunit 12 MIS13 PF08202.11 EMC79744.1 - 1.3e-19 70.6 3.3 1.1e-18 67.6 3.4 1.9 1 1 0 1 1 1 1 Mis12-Mtw1 protein family Ribosomal_L39 PF00832.20 EMC79744.1 - 0.031 13.9 1.8 0.093 12.4 1.8 1.8 1 0 0 1 1 1 0 Ribosomal L39 protein PBC PF03792.13 EMC79745.1 - 6.2e-82 274.0 0.7 8.9e-82 273.4 0.1 1.6 2 0 0 2 2 2 1 PBC domain Homeodomain PF00046.29 EMC79745.1 - 1.5e-18 66.4 0.5 3.1e-18 65.3 0.5 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC79745.1 - 2.5e-15 56.1 0.0 9e-15 54.3 0.0 2.0 2 0 0 2 2 2 1 Homeobox KN domain HTH_3 PF01381.22 EMC79745.1 - 0.02 14.9 0.0 0.05 13.7 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix Sec15 PF04091.12 EMC79745.1 - 0.03 13.8 0.3 0.045 13.2 0.3 1.2 1 0 0 1 1 1 0 Exocyst complex subunit Sec15-like YdaS_antitoxin PF15943.5 EMC79745.1 - 0.15 11.9 0.0 0.45 10.4 0.0 1.8 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT NUC130_3NT PF08158.12 EMC79745.1 - 0.22 11.9 1.0 22 5.5 0.1 3.1 3 0 0 3 3 3 0 NUC130/3NT domain 7tm_1 PF00001.21 EMC79746.1 - 1.7e-34 119.3 23.6 2.3e-34 118.9 23.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC79746.1 - 1.6e-11 44.1 23.6 2.1e-11 43.7 23.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx RhoGAP PF00620.27 EMC79747.1 - 8.5e-40 136.1 0.1 2.1e-38 131.5 0.0 2.8 2 1 0 2 2 2 1 RhoGAP domain C1_1 PF00130.22 EMC79747.1 - 4e-05 23.4 13.0 4.3e-05 23.3 11.5 1.9 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) FCH PF00611.23 EMC79747.1 - 0.013 15.8 2.0 0.073 13.4 1.4 2.7 2 1 1 3 3 3 0 Fes/CIP4, and EFC/F-BAR homology domain IF-2B PF01008.17 EMC79747.1 - 0.11 11.7 0.1 0.19 10.9 0.1 1.3 1 0 0 1 1 1 0 Initiation factor 2 subunit family Atg14 PF10186.9 EMC79747.1 - 7.8 5.5 17.4 1.3 8.0 11.9 2.2 2 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 AMP-binding PF00501.28 EMC79748.1 - 2.2e-69 234.1 0.0 2.6e-69 233.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMC79748.1 - 1.3e-06 29.3 0.1 2.7e-06 28.3 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain HHH_3 PF12836.7 EMC79749.1 - 5.7e-42 141.8 0.2 1.2e-20 73.5 0.1 2.4 2 0 0 2 2 2 2 Helix-hairpin-helix motif HHH PF00633.23 EMC79749.1 - 4e-17 61.1 0.1 1.3e-06 27.9 0.0 3.7 3 0 0 3 3 3 3 Helix-hairpin-helix motif HHH_6 PF14579.6 EMC79749.1 - 7.6e-09 35.7 0.0 5.8e-05 23.3 0.0 2.5 2 0 0 2 2 2 2 Helix-hairpin-helix motif T2SSK PF03934.13 EMC79749.1 - 3.8e-08 33.1 0.0 0.0022 17.5 0.0 2.2 2 0 0 2 2 2 2 Type II secretion system (T2SS), protein K Exo_endo_phos PF03372.23 EMC79749.1 - 8.6e-08 32.0 0.0 2.3e-07 30.6 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family HHH_2 PF12826.7 EMC79749.1 - 1.2e-07 31.7 0.1 0.02 15.0 0.0 3.0 3 0 0 3 3 3 2 Helix-hairpin-helix motif HHH_5 PF14520.6 EMC79749.1 - 1.2e-05 25.9 0.3 1.1 9.9 0.1 4.1 3 2 2 5 5 5 4 Helix-hairpin-helix domain PsbU PF06514.11 EMC79749.1 - 0.0058 16.6 0.0 0.67 10.0 0.0 2.4 2 0 0 2 2 2 1 Photosystem II 12 kDa extrinsic protein (PsbU) Exo_endo_phos_2 PF14529.6 EMC79749.1 - 0.036 13.9 0.3 0.13 12.1 0.3 2.0 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase DUF1704 PF08014.11 EMC79750.1 - 2.9e-15 56.2 0.1 4.7e-14 52.2 0.0 2.2 1 1 0 2 2 2 1 Domain of unknown function (DUF1704) GN3L_Grn1 PF08701.11 EMC79750.1 - 0.021 14.9 7.9 0.046 13.8 7.9 1.5 1 0 0 1 1 1 0 GNL3L/Grn1 putative GTPase DUF5323 PF17257.2 EMC79750.1 - 0.7 9.8 10.7 4.8 7.1 0.9 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5323) Anillin PF08174.11 EMC79751.1 - 2.3e-38 131.8 0.3 6.3e-38 130.4 0.3 1.8 1 0 0 1 1 1 1 Cell division protein anillin Anillin_N PF16018.5 EMC79751.1 - 2e-37 127.6 10.9 9.3e-34 115.9 1.0 4.5 3 1 1 4 4 4 2 Anillin N-terminus PH PF00169.29 EMC79751.1 - 6.6e-18 65.2 1.3 1.4e-17 64.1 0.2 2.3 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 EMC79751.1 - 0.019 15.4 0.1 0.08 13.4 0.1 2.2 1 0 0 1 1 1 0 Pleckstrin homology domain Lipase_GDSL PF00657.22 EMC79752.1 - 1.2e-14 54.8 0.0 1.8e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase SapB_2 PF03489.17 EMC79752.1 - 1.1e-05 25.4 0.8 3.9e-05 23.7 0.8 1.9 1 0 0 1 1 1 1 Saposin-like type B, region 2 Cu-binding_MopE PF11617.8 EMC79752.1 - 0.026 14.7 4.4 0.026 14.7 4.4 2.4 2 1 0 2 2 2 0 Putative metal-binding motif DUF3361 PF11841.8 EMC79753.1 - 6.5e-62 208.0 3.5 1.4e-61 207.0 3.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) ELMO_CED12 PF04727.13 EMC79753.1 - 1e-42 146.2 1.0 2.1e-42 145.2 1.0 1.5 1 0 0 1 1 1 1 ELMO/CED-12 family PH_12 PF16457.5 EMC79753.1 - 7.7e-39 133.3 0.1 3.2e-38 131.3 0.0 2.2 3 0 0 3 3 3 1 Pleckstrin homology domain ZFYVE21_C PF16696.5 EMC79753.1 - 0.067 13.1 0.1 0.26 11.2 0.0 2.1 2 0 0 2 2 2 0 Zinc finger FYVE domain-containing protein 21 C-terminus FERM_N PF09379.10 EMC79753.1 - 0.076 13.0 0.0 0.71 9.9 0.0 2.5 3 0 0 3 3 3 0 FERM N-terminal domain 7tm_1 PF00001.21 EMC79754.1 - 3.8e-09 36.3 25.7 7.1e-09 35.4 25.7 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4131 PF13567.6 EMC79754.1 - 4.5 6.9 8.2 2.8 7.6 2.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) 7tm_1 PF00001.21 EMC79755.1 - 2.6e-07 30.3 24.9 5.2e-07 29.2 24.1 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) NDK PF00334.19 EMC79756.1 - 2.6e-98 325.4 0.0 1.6e-39 135.0 0.2 3.5 3 1 1 4 4 4 3 Nucleoside diphosphate kinase Thioredoxin PF00085.20 EMC79756.1 - 1.1e-10 41.5 0.2 2.9e-10 40.1 0.2 1.8 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 EMC79756.1 - 0.00037 20.4 0.0 0.0012 18.7 0.0 1.9 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EMC79756.1 - 0.00085 19.1 0.1 0.002 17.9 0.1 1.6 1 0 0 1 1 1 1 Redoxin DUF4162 PF13732.6 EMC79756.1 - 0.02 15.6 2.5 1.8 9.4 0.2 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4162) DUF4898 PF16239.5 EMC79756.1 - 0.038 13.9 0.9 0.75 9.8 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4898) Glutaredoxin PF00462.24 EMC79756.1 - 0.11 12.7 0.0 0.48 10.7 0.0 2.1 1 0 0 1 1 1 0 Glutaredoxin DAHP_snth_FXD PF18152.1 EMC79756.1 - 0.11 12.3 2.1 5.1 7.0 0.1 3.5 3 1 1 4 4 4 0 DAHP synthase ferredoxin-like domain DnaI_N PF07319.11 EMC79756.1 - 0.43 11.3 3.5 34 5.2 0.1 3.5 3 0 0 3 3 3 0 Primosomal protein DnaI N-terminus Fz PF01392.22 EMC79758.1 - 4e-17 62.8 9.6 1.2e-08 35.6 0.7 2.8 2 2 1 3 3 3 2 Fz domain NTR PF01759.21 EMC79758.1 - 1.5e-14 53.7 1.1 2.2e-14 53.2 0.2 1.7 1 1 1 2 2 2 1 UNC-6/NTR/C345C module MENTAL PF10457.9 EMC79759.1 - 1.2e-63 214.2 5.1 1.4e-63 213.9 5.1 1.1 1 0 0 1 1 1 1 Cholesterol-capturing domain Mlh1_C PF16413.5 EMC79760.1 - 3.1e-61 207.1 0.3 5.2e-61 206.4 0.3 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 EMC79760.1 - 2.7e-34 117.4 0.2 5e-34 116.5 0.2 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EMC79760.1 - 9.1e-14 51.5 0.2 1.9e-13 50.4 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EMC79760.1 - 1.3e-07 32.1 0.0 5e-07 30.2 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CAF1 PF04857.20 EMC79760.1 - 0.0079 15.4 0.3 0.15 11.2 0.0 2.1 1 1 1 2 2 2 1 CAF1 family ribonuclease TPR_2 PF07719.17 EMC79761.1 - 0.0033 17.4 0.2 0.41 10.9 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF3856 PF12968.7 EMC79761.1 - 0.037 14.1 0.0 2.8 8.0 0.0 2.3 2 1 0 2 2 2 0 Domain of Unknown Function (DUF3856) ANAPC3 PF12895.7 EMC79761.1 - 0.055 13.7 0.4 1.1 9.6 0.1 2.6 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EMC79761.1 - 0.079 13.2 0.1 2.3 8.7 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 EMC79761.1 - 0.094 12.4 0.5 0.22 11.2 0.5 1.7 1 1 0 1 1 1 0 TPR repeat TPR_6 PF13174.6 EMC79761.1 - 0.14 12.8 0.1 6.2 7.7 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat UvrD_C PF13361.6 EMC79762.1 - 2.4e-07 30.5 0.2 0.00068 19.1 0.0 4.8 3 2 2 5 5 5 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 EMC79762.1 - 1.5e-06 28.0 0.9 1.5e-06 28.0 0.9 3.8 3 2 0 3 3 3 1 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.6 EMC79762.1 - 2.6e-06 27.2 0.0 0.1 12.4 0.0 2.5 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain Ank_2 PF12796.7 EMC79762.1 - 1.2e-05 25.8 0.0 3.3e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC79762.1 - 0.00069 20.1 0.2 0.076 13.6 0.0 3.0 1 1 1 2 2 2 1 Ankyrin repeats (many copies) AAA_19 PF13245.6 EMC79762.1 - 0.0036 17.6 0.0 0.79 10.1 0.0 3.0 2 0 0 2 2 2 1 AAA domain Clathrin PF00637.20 EMC79762.1 - 0.016 15.1 21.8 0.067 13.1 3.6 4.9 5 1 1 6 6 6 0 Region in Clathrin and VPS ABC_tran PF00005.27 EMC79762.1 - 0.046 14.2 0.7 0.18 12.3 0.0 2.5 2 0 0 2 2 2 0 ABC transporter AAA_22 PF13401.6 EMC79762.1 - 0.055 13.7 0.1 1.6 9.0 0.0 3.2 2 0 0 2 2 2 0 AAA domain STAC2_u1 PF16664.5 EMC79763.1 - 3.2e-31 108.5 2.6 7.4e-31 107.3 0.4 2.1 2 0 0 2 2 2 1 Unstructured on SH3 and cysteine-rich domain-containing protein 2 SH3_9 PF14604.6 EMC79763.1 - 8.9e-20 70.3 0.0 1.1e-15 57.1 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 EMC79763.1 - 5.8e-17 61.0 0.5 8.9e-15 54.0 0.1 2.3 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EMC79763.1 - 1.1e-16 60.3 0.2 4.2e-07 29.5 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain C1_1 PF00130.22 EMC79763.1 - 5.4e-10 39.0 10.6 5.4e-10 39.0 10.6 1.8 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_9 PF13901.6 EMC79763.1 - 0.0041 17.1 3.4 0.008 16.2 3.4 1.4 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon C1_2 PF03107.16 EMC79763.1 - 0.0068 16.7 3.3 0.0068 16.7 3.3 2.1 2 0 0 2 2 2 1 C1 domain RNA_POL_M_15KD PF02150.16 EMC79763.1 - 0.081 12.8 1.3 0.17 11.8 1.3 1.5 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit BssC_TutF PF08201.11 EMC79763.1 - 0.15 12.1 1.1 0.29 11.2 0.0 2.0 2 0 0 2 2 2 0 BssC/TutF protein PHD PF00628.29 EMC79763.1 - 0.26 11.2 8.2 0.59 10.1 8.2 1.6 1 0 0 1 1 1 0 PHD-finger Zf_RING PF16744.5 EMC79763.1 - 1.4 9.1 6.3 0.64 10.2 3.7 1.8 2 0 0 2 2 2 0 KIAA1045 RING finger zf-RING-like PF08746.11 EMC79763.1 - 1.9 8.8 10.2 5.1 7.5 10.2 1.7 1 0 0 1 1 1 0 RING-like domain R3H PF01424.22 EMC79764.1 - 3.1e-12 46.3 0.6 9.1e-12 44.8 0.1 2.1 2 0 0 2 2 2 1 R3H domain 7tm_4 PF13853.6 EMC79767.1 - 7.1e-29 101.4 13.0 2.4e-20 73.4 6.0 2.0 1 1 1 2 2 2 2 Olfactory receptor 7tm_1 PF00001.21 EMC79767.1 - 1.5e-12 47.5 15.0 8.2e-09 35.2 0.3 2.2 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) EGF_CA PF07645.15 EMC79768.1 - 1.4e-19 70.0 39.6 1.1e-10 41.6 7.6 6.1 4 2 1 5 5 5 3 Calcium-binding EGF domain EGF PF00008.27 EMC79768.1 - 4.4e-11 42.9 73.9 6.8e-05 23.1 5.9 6.0 6 1 0 6 6 6 4 EGF-like domain FXa_inhibition PF14670.6 EMC79768.1 - 6.8e-10 39.1 68.4 0.0011 19.1 9.4 5.6 2 2 2 5 5 5 4 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 EMC79768.1 - 1.1e-09 38.3 22.9 5.8e-08 32.8 11.0 6.1 3 2 2 5 5 5 3 EGF domain cEGF PF12662.7 EMC79768.1 - 8e-07 28.9 50.0 0.0058 16.5 0.2 6.2 6 0 0 6 6 6 5 Complement Clr-like EGF-like hEGF PF12661.7 EMC79768.1 - 0.0012 19.4 1.2 0.0012 19.4 1.2 7.6 7 0 0 7 7 7 3 Human growth factor-like EGF EGF_MSP1_1 PF12946.7 EMC79768.1 - 0.44 10.6 53.3 0.051 13.6 4.1 5.7 5 0 0 5 5 5 0 MSP1 EGF domain 1 Thymosin PF01290.20 EMC79770.1 - 3.4e-23 81.1 10.7 3.7e-23 81.0 10.7 1.0 1 0 0 1 1 1 1 Thymosin beta-4 family WH2 PF02205.20 EMC79770.1 - 0.0023 17.7 0.1 0.003 17.3 0.1 1.2 1 0 0 1 1 1 1 WH2 motif DUF4522 PF15022.6 EMC79770.1 - 0.028 14.7 0.2 0.03 14.6 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4522) LRR_8 PF13855.6 EMC79771.1 - 2.2e-77 254.7 87.6 4.1e-10 39.3 3.1 14.7 11 4 3 14 14 14 14 Leucine rich repeat LRR_4 PF12799.7 EMC79771.1 - 4.5e-37 125.4 99.2 2.6e-05 24.5 5.1 15.7 7 5 9 17 17 17 15 Leucine Rich repeats (2 copies) TIR PF01582.20 EMC79771.1 - 7.8e-17 61.6 0.3 1.2e-16 61.0 0.3 1.2 1 0 0 1 1 1 1 TIR domain LRR_5 PF13306.6 EMC79771.1 - 3.9e-15 55.9 21.3 9.7e-06 25.6 0.1 6.7 5 2 1 6 6 6 4 BspA type Leucine rich repeat region (6 copies) LRR_12 PF18837.1 EMC79771.1 - 2e-11 43.3 0.1 2e-11 43.3 0.1 4.2 4 0 0 4 4 4 1 Leucine-rich repeat LRR_1 PF00560.33 EMC79771.1 - 2.2e-10 39.6 78.7 1.6 9.6 0.1 20.5 20 3 1 21 21 21 7 Leucine Rich Repeat LRR_9 PF14580.6 EMC79771.1 - 1.6e-09 37.5 43.9 0.0054 16.3 6.4 8.4 4 2 6 10 10 10 7 Leucine-rich repeat TIR_2 PF13676.6 EMC79771.1 - 2.4e-08 34.6 0.2 7.5e-08 33.0 0.1 1.8 2 0 0 2 2 2 1 TIR domain LRRNT PF01462.18 EMC79771.1 - 0.034 13.8 0.0 0.034 13.8 0.0 4.8 7 0 0 7 7 7 0 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 EMC79771.1 - 4.3 7.6 72.7 2.9 8.2 0.0 16.6 20 0 0 20 20 20 0 Leucine Rich repeat Pribosyl_synth PF14572.6 EMC79772.1 - 7.5e-45 153.2 1.9 2.7e-37 128.6 0.6 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 EMC79772.1 - 1.1e-41 141.4 0.1 4.6e-41 139.4 0.0 2.0 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EMC79772.1 - 1.3e-13 50.8 0.2 2.7e-13 49.7 0.2 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EMC79772.1 - 0.00039 19.9 0.1 0.00069 19.1 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase FERM_M PF00373.18 EMC79773.1 - 3.1e-18 66.3 0.1 9.3e-18 64.8 0.1 1.9 1 0 0 1 1 1 1 FERM central domain PDZ PF00595.24 EMC79773.1 - 1.6e-10 41.2 0.0 3.6e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC79773.1 - 1.6e-07 31.1 0.1 3.7e-07 29.9 0.1 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC79773.1 - 4.5e-05 23.7 0.0 0.00019 21.7 0.0 2.1 1 0 0 1 1 1 1 PDZ domain WW PF00397.26 EMC79773.1 - 0.0013 18.7 0.1 0.0031 17.6 0.1 1.7 1 0 0 1 1 1 1 WW domain FERM_f0 PF16511.5 EMC79773.1 - 0.0035 17.6 0.0 0.0083 16.4 0.0 1.6 1 0 0 1 1 1 1 N-terminal or F0 domain of Talin-head FERM Vfa1 PF08432.10 EMC79773.1 - 1.1 9.5 9.8 0.18 12.1 3.0 2.6 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 MRG PF05712.13 EMC79774.1 - 5e-70 234.8 0.5 7.1e-70 234.3 0.5 1.2 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 EMC79774.1 - 3.9e-05 23.5 0.4 9.9e-05 22.1 0.4 1.8 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.24 EMC79774.1 - 0.018 15.0 0.2 0.044 13.7 0.2 1.7 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain ABC_tran PF00005.27 EMC79777.1 - 2.1e-33 115.7 0.0 2.7e-33 115.4 0.0 1.1 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EMC79777.1 - 2.7e-07 30.3 0.0 5.3e-05 22.8 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EMC79777.1 - 0.00014 22.2 0.1 0.0014 18.9 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EMC79777.1 - 0.00029 21.3 0.7 0.00076 19.9 0.7 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 EMC79777.1 - 0.0055 16.4 1.7 0.037 13.7 1.7 2.1 1 1 0 1 1 1 1 AAA domain ABC_ATPase PF09818.9 EMC79777.1 - 0.0069 15.2 0.1 0.034 12.9 0.1 1.8 2 0 0 2 2 2 1 Predicted ATPase of the ABC class SbcCD_C PF13558.6 EMC79777.1 - 0.0078 16.4 0.9 0.18 12.0 0.9 2.4 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit APS_kinase PF01583.20 EMC79777.1 - 0.025 14.5 0.0 0.057 13.3 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase IstB_IS21 PF01695.17 EMC79777.1 - 0.034 13.9 0.4 2.6 7.8 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_25 PF13481.6 EMC79777.1 - 0.038 13.6 0.4 4 7.0 0.1 2.3 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 EMC79777.1 - 0.053 13.6 0.0 0.19 11.8 0.0 1.7 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_5 PF07728.14 EMC79777.1 - 0.053 13.5 0.0 0.46 10.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF3987 PF13148.6 EMC79777.1 - 0.07 12.1 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) DEAD PF00270.29 EMC79777.1 - 0.07 12.9 0.1 0.67 9.7 0.1 2.0 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_29 PF13555.6 EMC79777.1 - 0.073 12.8 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 EMC79777.1 - 0.099 11.9 0.0 0.22 10.7 0.0 1.5 2 0 0 2 2 2 0 Zeta toxin AAA PF00004.29 EMC79777.1 - 0.099 13.1 1.2 1.5 9.2 1.2 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EMC79777.1 - 0.1 12.8 0.7 0.26 11.5 0.1 1.9 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EMC79777.1 - 0.11 13.1 0.0 0.19 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 EMC79777.1 - 0.11 12.2 0.7 0.25 11.0 0.4 1.8 1 1 1 2 2 2 0 Cytidylate kinase AAA_24 PF13479.6 EMC79777.1 - 0.13 12.0 0.1 0.18 11.5 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 EMC79777.1 - 0.15 11.8 0.3 4.1 7.1 0.1 2.1 1 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EMC79777.1 - 0.17 11.8 0.0 0.29 11.0 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase ASC PF00858.24 EMC79778.1 - 6.3e-71 239.6 0.0 6.5e-70 236.3 0.0 1.9 1 1 0 1 1 1 1 Amiloride-sensitive sodium channel Pkinase PF00069.25 EMC79779.1 - 1.3e-21 77.2 0.0 2.2e-18 66.6 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMC79779.1 - 3.4e-10 39.6 0.0 1.2e-08 34.5 0.0 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase Sugar_tr PF00083.24 EMC79781.1 - 7.9e-18 64.5 18.0 9.7e-16 57.7 3.3 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EMC79781.1 - 1.1e-16 60.8 31.4 1.3e-15 57.3 30.9 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 EMC79782.1 - 4e-28 98.3 28.7 5e-28 98.0 28.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMC79782.1 - 1.2e-26 93.6 21.5 1.6e-26 93.2 21.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter eIF-5a PF01287.20 EMC79782.1 - 0.043 13.9 0.2 0.077 13.1 0.2 1.3 1 0 0 1 1 1 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold RhoGEF PF00621.20 EMC79784.1 - 8.3e-44 150.0 2.4 8.3e-44 150.0 2.4 1.9 2 1 0 2 2 2 1 RhoGEF domain SH3_1 PF00018.28 EMC79784.1 - 1.9e-10 40.1 1.8 4e-10 39.1 1.8 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC79784.1 - 1.2e-09 37.7 0.0 2.9e-09 36.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EMC79784.1 - 3.7e-09 36.3 0.1 7.6e-09 35.3 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.29 EMC79784.1 - 3.3e-07 30.8 0.3 7.1e-07 29.7 0.3 1.5 1 0 0 1 1 1 1 PH domain Pkinase_Tyr PF07714.17 EMC79786.1 - 4.4e-104 347.3 0.0 7.9e-104 346.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase I-set PF07679.16 EMC79786.1 - 9.5e-55 182.7 4.1 2.1e-18 66.1 0.0 5.9 5 1 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC79786.1 - 6.1e-53 177.3 15.0 7e-14 52.2 0.0 6.6 6 1 0 6 6 6 5 Immunoglobulin domain Pkinase PF00069.25 EMC79786.1 - 3.5e-42 144.6 0.0 2.4e-28 99.2 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain ig PF00047.25 EMC79786.1 - 3.9e-35 119.9 13.2 8.6e-10 38.7 0.6 7.0 6 1 0 6 6 6 4 Immunoglobulin domain Ig_2 PF13895.6 EMC79786.1 - 1.9e-32 111.4 17.6 3.2e-09 37.0 0.0 7.1 6 1 0 6 6 6 5 Immunoglobulin domain V-set PF07686.17 EMC79786.1 - 5.4e-19 68.4 13.4 0.0054 16.9 0.8 7.4 5 3 1 6 6 6 5 Immunoglobulin V-set domain VEGFR-2_TMD PF17988.1 EMC79786.1 - 7.5e-18 63.7 0.7 1.6e-17 62.7 0.7 1.6 1 0 0 1 1 1 1 VEGFR-2 Transmembrane domain Ig_4 PF16680.5 EMC79786.1 - 3.1e-10 40.2 1.6 0.0028 17.9 0.0 5.3 5 0 0 5 5 5 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 EMC79786.1 - 9.8e-07 28.8 2.2 0.041 14.0 0.0 4.3 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 EMC79786.1 - 3e-06 26.7 0.1 0.8 9.3 0.0 4.9 5 0 0 5 5 5 2 Immunoglobulin domain Izumo-Ig PF16706.5 EMC79786.1 - 7.7e-06 25.9 4.1 2.6 8.2 0.1 5.4 6 0 0 6 6 6 3 Izumo-like Immunoglobulin domain C2-set PF05790.15 EMC79786.1 - 0.011 15.9 0.6 31 4.8 0.0 4.6 5 0 0 5 5 5 0 Immunoglobulin C2-set domain Herpes_gE PF02480.16 EMC79786.1 - 0.012 14.4 0.1 5.4 5.7 0.0 3.2 2 1 0 3 3 3 0 Alphaherpesvirus glycoprotein E Haspin_kinase PF12330.8 EMC79786.1 - 0.025 13.5 0.0 0.044 12.7 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Adeno_E3_CR1 PF02440.15 EMC79786.1 - 0.059 13.2 11.1 0.77 9.6 0.3 5.0 5 1 0 5 5 5 0 Adenovirus E3 region protein CR1 Receptor_2B4 PF11465.8 EMC79786.1 - 0.081 13.1 0.1 30 4.9 0.0 4.1 5 0 0 5 5 5 0 Natural killer cell receptor 2B4 Hydrophob_seed PF14547.6 EMC79786.1 - 0.095 12.9 0.9 5 7.4 0.3 2.9 3 0 0 3 3 3 0 Hydrophobic seed protein PMC2NT PF08066.12 EMC79786.1 - 0.11 13.2 1.2 0.48 11.1 0.3 2.4 2 0 0 2 2 2 0 PMC2NT (NUC016) domain Caudal_act PF04731.12 EMC79787.1 - 3.4e-55 186.1 15.6 5.7e-55 185.4 15.6 1.3 1 0 0 1 1 1 1 Caudal like protein activation region Homeodomain PF00046.29 EMC79787.1 - 5.4e-20 71.0 6.0 8.6e-20 70.3 6.0 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC79787.1 - 0.01 15.7 0.9 0.021 14.7 0.9 1.5 1 0 0 1 1 1 0 Homeobox KN domain Homez PF11569.8 EMC79787.1 - 0.22 11.0 0.9 0.36 10.3 0.1 1.8 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez Mito_fiss_reg PF05308.11 EMC79787.1 - 1.4 9.0 9.5 0.76 9.8 3.5 2.2 2 0 0 2 2 2 0 Mitochondrial fission regulator Caudal_act PF04731.12 EMC79788.1 - 4e-52 176.2 13.8 5.7e-52 175.7 13.8 1.2 1 0 0 1 1 1 1 Caudal like protein activation region Homeodomain PF00046.29 EMC79788.1 - 1.3e-21 76.2 3.2 2e-21 75.5 3.2 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC79788.1 - 0.003 17.4 0.3 0.0058 16.5 0.3 1.4 1 0 0 1 1 1 1 Homeobox KN domain YdaS_antitoxin PF15943.5 EMC79788.1 - 0.086 12.7 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Erf4 PF10256.9 EMC79789.1 - 4.5e-10 39.7 0.0 6.7e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Fip1 PF05182.13 EMC79790.1 - 5.7e-26 89.8 1.8 8.7e-26 89.2 1.8 1.3 1 0 0 1 1 1 1 Fip1 motif DUF5404 PF17397.2 EMC79790.1 - 2.5e-11 43.9 0.8 3.9e-11 43.3 0.8 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5404) Cwf_Cwc_15 PF04889.12 EMC79790.1 - 4.2 7.0 8.3 5.6 6.6 8.3 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PDZ PF00595.24 EMC79791.1 - 1.2e-62 208.2 3.8 2.9e-16 59.6 0.1 4.2 4 0 0 4 4 4 4 PDZ domain PDZ_6 PF17820.1 EMC79791.1 - 5.6e-34 115.8 0.8 5.8e-08 32.5 0.0 4.4 4 0 0 4 4 4 4 PDZ domain PDZ_2 PF13180.6 EMC79791.1 - 2.7e-18 66.1 0.5 0.0061 16.9 0.0 4.4 4 0 0 4 4 4 4 PDZ domain LCE PF14672.6 EMC79791.1 - 1.1 9.9 5.5 0.25 12.0 1.7 1.8 2 0 0 2 2 2 0 Late cornified envelope Ras PF00071.22 EMC79792.1 - 4.4e-30 104.4 0.0 1.7e-29 102.5 0.0 1.7 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EMC79792.1 - 4.9e-08 33.2 0.0 2.5e-07 30.9 0.0 2.0 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC79792.1 - 0.00076 19.0 0.0 0.28 10.6 0.0 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC79792.1 - 0.0015 18.6 0.0 0.0024 17.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC79792.1 - 0.0093 15.9 0.0 0.55 10.1 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase SRPRB PF09439.10 EMC79792.1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 EMC79792.1 - 0.19 11.4 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain 7tm_1 PF00001.21 EMC79793.1 - 1.7e-28 99.7 11.8 2e-28 99.5 11.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) MFS_1 PF07690.16 EMC79794.1 - 2.4e-11 43.2 3.1 2.6e-11 43.1 3.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily zf-RING_2 PF13639.6 EMC79795.1 - 3.5e-13 49.7 8.0 5.5e-13 49.0 8.0 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EMC79795.1 - 3.5e-10 40.0 4.8 7e-10 39.0 4.8 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EMC79795.1 - 1.6e-08 34.1 3.4 1.6e-08 34.1 3.4 1.7 2 0 0 2 2 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EMC79795.1 - 4.7e-08 32.7 6.2 7.4e-08 32.1 6.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC79795.1 - 1.9e-06 27.6 7.6 3.1e-06 26.9 7.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC79795.1 - 4.3e-05 23.4 6.3 6.8e-05 22.8 6.3 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EMC79795.1 - 4.5e-05 23.4 1.4 9.5e-05 22.4 1.4 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EMC79795.1 - 0.00056 19.7 4.7 0.00095 19.0 4.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC79795.1 - 0.0017 18.2 4.5 0.003 17.4 4.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EMC79795.1 - 0.0047 16.9 4.0 0.01 15.8 4.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 EMC79795.1 - 0.15 11.8 5.1 0.23 11.1 5.1 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-HC5HC2H_2 PF13832.6 EMC79795.1 - 0.16 12.2 1.2 0.3 11.3 1.2 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-RING_4 PF14570.6 EMC79795.1 - 0.17 11.7 4.5 0.32 10.8 4.5 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.11 EMC79795.1 - 0.24 11.7 6.2 0.4 11.0 6.2 1.4 1 0 0 1 1 1 0 RING-like domain RINGv PF12906.7 EMC79795.1 - 1.1 9.4 7.4 2.3 8.4 7.4 1.6 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 EMC79795.1 - 1.9 8.7 5.0 6.8 6.9 5.0 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain GREB1 PF15782.5 EMC79795.1 - 7.5 3.5 11.2 9.9 3.1 11.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4683 PF15735.5 EMC79796.1 - 4.7e-125 418.4 8.7 4.7e-125 418.4 8.7 3.7 4 0 0 4 4 4 1 Domain of unknown function (DUF4683) ABC_membrane PF00664.23 EMC79797.1 - 1.2e-36 126.8 9.6 1.5e-36 126.4 9.6 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EMC79797.1 - 3.2e-35 121.6 0.0 8e-35 120.3 0.0 1.7 2 0 0 2 2 1 1 ABC transporter SMC_N PF02463.19 EMC79797.1 - 1.7e-05 24.4 0.2 0.0061 16.0 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EMC79797.1 - 0.00099 19.5 0.0 0.0026 18.2 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 EMC79797.1 - 0.0056 16.4 1.1 0.011 15.5 0.2 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF87 PF01935.17 EMC79797.1 - 0.0088 16.2 0.7 0.025 14.7 0.0 2.0 2 0 0 2 2 2 1 Helicase HerA, central domain G-alpha PF00503.20 EMC79797.1 - 0.027 13.7 0.1 0.077 12.1 0.1 1.8 1 1 0 1 1 1 0 G-protein alpha subunit AAA_22 PF13401.6 EMC79797.1 - 0.048 13.9 0.6 0.16 12.2 0.1 2.2 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EMC79797.1 - 0.07 13.7 0.6 1.3 9.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EMC79797.1 - 0.071 13.4 0.0 0.18 12.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EMC79797.1 - 0.077 12.5 0.0 0.74 9.3 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_30 PF13604.6 EMC79797.1 - 0.093 12.4 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EMC79797.1 - 0.16 11.7 0.2 0.57 9.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EMC79797.1 - 0.83 10.1 0.0 0.83 10.1 0.0 2.4 3 0 0 3 3 2 0 AAA domain UPRTase PF14681.6 EMC79798.1 - 3.4e-46 157.3 0.0 4.2e-46 157.0 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EMC79798.1 - 0.00013 21.5 0.0 0.00016 21.2 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain FGF PF00167.18 EMC79799.1 - 4.8e-34 117.2 0.1 5.4e-34 117.0 0.1 1.0 1 0 0 1 1 1 1 Fibroblast growth factor MecA PF05389.12 EMC79799.1 - 0.18 11.4 0.1 0.21 11.2 0.1 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) Helicase_C PF00271.31 EMC79800.1 - 1.9e-16 60.4 0.2 1.4e-15 57.5 0.0 2.4 2 1 0 2 2 2 1 Helicase conserved C-terminal domain SUIM_assoc PF16619.5 EMC79800.1 - 0.32 11.1 4.5 0.95 9.6 4.5 1.8 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 zf-C4H2 PF10146.9 EMC79800.1 - 5.2 7.3 10.5 0.97 9.7 6.5 1.7 2 0 0 2 2 2 0 Zinc finger-containing protein SNF2_N PF00176.23 EMC79801.1 - 6.6e-37 127.0 0.0 7.1e-37 126.9 0.0 1.0 1 0 0 1 1 1 1 SNF2 family N-terminal domain 7tm_1 PF00001.21 EMC79802.1 - 5.1e-57 193.2 24.1 6.5e-57 192.8 24.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC79802.1 - 2e-10 40.5 26.8 2.6e-10 40.1 26.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC79802.1 - 3.6e-05 23.6 21.7 5.2e-05 23.1 21.7 1.2 1 0 0 1 1 1 1 Olfactory receptor Hexokinase_2 PF03727.16 EMC79803.1 - 2.4e-172 570.6 0.9 1.6e-87 292.9 0.2 2.3 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.21 EMC79803.1 - 2.3e-143 474.9 0.2 1.4e-72 243.8 0.1 2.3 2 0 0 2 2 2 2 Hexokinase CSD PF00313.22 EMC79803.1 - 0.0033 17.2 0.0 0.19 11.6 0.0 2.7 2 0 0 2 2 2 1 'Cold-shock' DNA-binding domain Hexokinase_2 PF03727.16 EMC79804.1 - 5.8e-169 559.5 1.1 5.9e-88 294.3 0.1 2.2 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.21 EMC79804.1 - 7.1e-135 447.1 0.0 6.2e-70 235.1 0.0 2.3 2 0 0 2 2 2 2 Hexokinase Pyridoxal_deC PF00282.19 EMC79804.1 - 0.0022 16.8 0.2 0.45 9.2 0.0 2.3 2 0 0 2 2 2 2 Pyridoxal-dependent decarboxylase conserved domain Suv3_N PF18114.1 EMC79805.1 - 5e-35 120.1 0.5 1.2e-34 119.0 0.5 1.7 1 0 0 1 1 1 1 Suv3 helical N-terminal domain SUV3_C PF12513.8 EMC79805.1 - 3.1e-16 59.0 0.0 7.9e-16 57.7 0.0 1.8 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Suv3_C_1 PF18147.1 EMC79805.1 - 1e-11 44.5 0.1 2.2e-11 43.5 0.1 1.5 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 Helicase_C PF00271.31 EMC79805.1 - 1.9e-11 44.3 0.0 4.1e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Vps26 PF03643.15 EMC79806.1 - 6.1e-133 442.0 4.5 7.1e-133 441.8 4.5 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_C PF02752.22 EMC79806.1 - 0.0067 16.9 0.1 0.18 12.2 0.0 2.3 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EMC79806.1 - 0.014 15.5 0.2 0.52 10.4 0.0 3.0 2 1 1 3 3 3 0 Arrestin (or S-antigen), N-terminal domain Serglycin PF04360.12 EMC79807.1 - 1.5e-26 93.1 0.0 1.5e-26 93.1 0.0 1.0 1 0 0 1 1 1 1 Serglycin GUCT PF08152.12 EMC79808.1 - 5.7e-33 113.1 0.0 3.8e-32 110.5 0.0 2.2 2 0 0 2 2 2 1 GUCT (NUC152) domain Helicase_C PF00271.31 EMC79808.1 - 1.2e-24 86.8 0.0 2.5e-24 85.8 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EMC79808.1 - 0.0058 15.9 0.0 0.012 14.8 0.0 1.5 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase FTR PF01913.18 EMC79808.1 - 0.16 11.9 0.1 1.3 9.0 0.0 2.1 2 0 0 2 2 2 0 Formylmethanofuran-tetrahydromethanopterin formyltransferase DBC1 PF14443.6 EMC79809.1 - 3.6e-52 175.6 1.4 7.9e-52 174.5 0.0 2.4 2 0 0 2 2 2 1 DBC1 S1-like PF14444.6 EMC79809.1 - 2.7e-33 113.7 0.9 4.9e-33 112.9 0.9 1.4 1 0 0 1 1 1 1 S1-like SAP PF02037.27 EMC79809.1 - 2.2e-08 33.7 4.7 2.7e-08 33.4 2.0 2.3 2 0 0 2 2 2 1 SAP domain Tautomerase_2 PF14552.6 EMC79809.1 - 0.03 14.4 0.1 0.12 12.4 0.0 2.1 2 0 0 2 2 2 0 Tautomerase enzyme DUF1456 PF07308.13 EMC79809.1 - 0.071 13.5 0.2 0.27 11.6 0.2 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1456) Tet_JBP PF12851.7 EMC79810.1 - 1.8e-73 247.8 0.0 1.8e-73 247.8 0.0 2.7 2 1 0 2 2 2 1 Oxygenase domain of the 2OGFeDO superfamily zf-CXXC PF02008.20 EMC79810.1 - 7.3e-05 22.7 28.8 7.3e-05 22.7 28.8 2.7 2 0 0 2 2 2 1 CXXC zinc finger domain Mito_carr PF00153.27 EMC79811.1 - 1.3e-67 223.8 6.5 3.9e-23 81.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EMC79811.1 - 0.00023 20.4 1.1 0.038 13.1 0.1 2.8 2 2 1 3 3 3 2 Gammaproteobacterial serine protease Dna2 PF08696.11 EMC79812.1 - 6.3e-64 215.5 0.3 1.3e-63 214.5 0.3 1.6 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_12 PF13087.6 EMC79812.1 - 3.7e-42 144.2 2.6 6.4e-42 143.4 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EMC79812.1 - 4.8e-32 111.8 3.5 1.2e-16 61.3 0.2 2.7 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.6 EMC79812.1 - 8.6e-15 55.0 0.0 2.1e-14 53.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EMC79812.1 - 3.7e-11 43.6 0.0 1.6e-10 41.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain PDDEXK_1 PF12705.7 EMC79812.1 - 3e-08 33.9 0.0 4.6e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Viral_helicase1 PF01443.18 EMC79812.1 - 6.6e-05 22.8 1.1 0.11 12.2 0.0 3.3 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase Cas_Cas4 PF01930.17 EMC79812.1 - 0.0001 22.5 7.8 0.0052 16.9 0.8 3.7 3 1 0 3 3 3 1 Domain of unknown function DUF83 SRP54 PF00448.22 EMC79812.1 - 0.0016 18.1 0.0 0.0033 17.1 0.0 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain cobW PF02492.19 EMC79812.1 - 0.0041 16.7 0.0 0.0071 16.0 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.23 EMC79812.1 - 0.01 15.9 0.4 0.029 14.4 0.4 1.7 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_25 PF13481.6 EMC79812.1 - 0.012 15.3 0.0 0.023 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain UvrD-helicase PF00580.21 EMC79812.1 - 0.014 14.9 4.1 0.019 14.5 0.0 2.6 2 1 1 3 3 3 0 UvrD/REP helicase N-terminal domain AAA_7 PF12775.7 EMC79812.1 - 0.016 14.7 0.2 0.037 13.6 0.2 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF853 PF05872.12 EMC79812.1 - 0.018 13.7 0.1 0.028 13.0 0.1 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) PhoH PF02562.16 EMC79812.1 - 0.019 14.4 1.2 0.047 13.1 0.1 2.4 2 1 0 2 2 2 0 PhoH-like protein AAA PF00004.29 EMC79812.1 - 0.026 15.0 0.0 0.064 13.7 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 EMC79812.1 - 0.042 14.3 4.1 0.12 12.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain Helicase_RecD PF05127.14 EMC79812.1 - 0.045 13.6 0.0 0.18 11.7 0.0 2.0 2 1 0 2 2 2 0 Helicase AAA_16 PF13191.6 EMC79812.1 - 0.061 13.7 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EMC79812.1 - 0.07 12.9 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 EMC79812.1 - 0.07 13.7 0.2 0.42 11.2 0.1 2.2 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 EMC79812.1 - 0.12 12.4 0.6 0.54 10.2 0.3 2.3 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit MobB PF03205.14 EMC79812.1 - 0.13 12.1 0.1 0.3 11.0 0.1 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B tRNA-synt_1e PF01406.19 EMC79812.1 - 0.14 11.5 1.1 0.83 8.9 0.5 2.1 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain RUN PF02759.19 EMC79813.1 - 2e-28 99.0 0.0 2e-28 99.0 0.0 2.5 2 1 0 2 2 2 1 RUN domain FYVE PF01363.21 EMC79813.1 - 2.4e-20 72.4 8.8 2.4e-20 72.4 8.8 1.9 2 0 0 2 2 2 1 FYVE zinc finger YabA PF06156.13 EMC79813.1 - 0.00049 20.7 5.7 0.00049 20.7 5.7 4.9 2 1 2 4 4 4 1 Initiation control protein YabA GIT_CC PF16559.5 EMC79813.1 - 0.0011 18.8 4.2 0.0011 18.8 4.2 5.7 5 2 1 6 6 5 1 GIT coiled-coil Rho guanine nucleotide exchange factor zf_C2HC_14 PF18574.1 EMC79813.1 - 0.26 11.1 6.2 0.54 10.1 6.2 1.5 1 0 0 1 1 1 0 C2HC Zing finger domain IBR PF01485.21 EMC79813.1 - 0.3 11.3 7.3 0.99 9.7 7.3 1.9 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain ADK_lid PF05191.14 EMC79813.1 - 0.36 10.8 9.9 0.071 13.1 6.0 1.8 2 0 0 2 2 2 0 Adenylate kinase, active site lid Trimer_CC PF08954.11 EMC79813.1 - 0.44 10.1 0.0 0.44 10.1 0.0 3.8 4 0 0 4 4 4 0 Trimerisation motif zf-RING_5 PF14634.6 EMC79813.1 - 0.81 9.7 13.2 1.6 8.8 13.2 1.5 1 0 0 1 1 1 0 zinc-RING finger domain C1_1 PF00130.22 EMC79813.1 - 2.1 8.3 16.4 2.5 8.0 10.5 2.4 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Cytokin_check_N PF10407.9 EMC79813.1 - 2.2 8.3 6.2 15 5.6 1.5 4.0 3 0 0 3 3 3 0 Cdc14 phosphatase binding protein N-terminus DUF724 PF05266.14 EMC79813.1 - 2.6 7.8 62.9 0.13 12.1 13.6 4.3 1 1 3 4 4 4 0 Protein of unknown function (DUF724) DZR PF12773.7 EMC79813.1 - 5.9 7.0 15.2 2.7 8.1 1.7 2.5 1 1 1 2 2 2 0 Double zinc ribbon Baculo_IE-1 PF05290.11 EMC79813.1 - 9 6.2 10.6 0.58 10.1 4.1 2.5 2 1 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) RRM_1 PF00076.22 EMC79814.1 - 1.1e-21 76.4 0.0 1.1e-10 41.2 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PhzC-PhzF PF02567.16 EMC79815.1 - 6.7e-61 206.2 0.0 8e-61 206.0 0.0 1.1 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein HLH PF00010.26 EMC79816.1 - 1.2e-18 66.8 0.1 1.7e-18 66.3 0.1 1.2 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DERM PF14704.6 EMC79816.1 - 0.027 15.0 0.7 0.19 12.2 0.3 2.0 1 1 1 2 2 2 0 Dermatopontin DUF1295 PF06966.12 EMC79816.1 - 0.089 12.3 0.1 0.12 11.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) SIR2 PF02146.17 EMC79817.1 - 2.7e-63 213.1 0.0 4.4e-63 212.4 0.0 1.4 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 EMC79817.1 - 0.001 18.8 0.0 0.42 10.4 0.0 2.3 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain DUF592 PF04574.13 EMC79817.1 - 0.0045 16.8 0.2 0.0077 16.0 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF592) DnaJ PF00226.31 EMC79818.1 - 4.4e-19 68.4 0.1 9.7e-19 67.3 0.1 1.6 1 0 0 1 1 1 1 DnaJ domain Vinculin PF01044.19 EMC79819.1 - 1.4e-43 149.4 2.1 1.5e-43 149.3 2.1 1.0 1 0 0 1 1 1 1 Vinculin family PilJ PF13675.6 EMC79819.1 - 0.013 15.6 2.4 0.24 11.5 0.3 2.2 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term HTH_57 PF18679.1 EMC79819.1 - 0.047 14.0 0.8 0.084 13.2 0.2 1.7 2 0 0 2 2 2 0 ThcOx helix turn helix domain TMEM89 PF15098.6 EMC79819.1 - 0.14 12.3 0.4 0.31 11.2 0.1 1.7 2 1 0 2 2 2 0 TMEM89 protein family LRR_8 PF13855.6 EMC79820.1 - 8.1e-55 182.4 60.8 2.4e-14 52.8 5.6 5.8 1 1 5 6 6 6 6 Leucine rich repeat LRR_5 PF13306.6 EMC79820.1 - 2.1e-31 108.5 1.5 7.5e-13 48.6 0.2 3.1 1 1 3 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 EMC79820.1 - 4.6e-19 68.2 39.5 5.7e-05 23.4 3.3 6.5 1 1 7 9 9 9 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC79820.1 - 4.1e-10 39.4 7.6 0.00015 21.3 3.2 3.5 1 1 3 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 EMC79820.1 - 7.8e-07 28.8 39.2 1.2 9.9 0.6 10.6 10 1 0 10 10 10 2 Leucine Rich Repeat LRR_6 PF13516.6 EMC79820.1 - 6.9e-06 25.7 30.7 1.1 9.5 0.2 9.6 10 0 0 10 10 10 2 Leucine Rich repeat LRRNT PF01462.18 EMC79820.1 - 3e-05 23.6 0.6 3e-05 23.6 0.6 2.5 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain EphA2_TM PF14575.6 EMC79820.1 - 0.11 13.3 0.2 0.33 11.8 0.1 1.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain LRR_2 PF07723.13 EMC79820.1 - 6.1 7.7 12.7 10 7.0 0.2 6.3 7 1 1 8 8 8 0 Leucine Rich Repeat Synaptobrevin PF00957.21 EMC79823.1 - 1.2e-28 98.7 0.4 1.3e-28 98.6 0.4 1.0 1 0 0 1 1 1 1 Synaptobrevin Ferlin_C PF16165.5 EMC79823.1 - 0.011 15.6 0.0 0.013 15.5 0.0 1.1 1 0 0 1 1 1 0 Ferlin C-terminus DUF2207 PF09972.9 EMC79823.1 - 0.085 11.6 0.0 0.087 11.6 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) MCU PF04678.13 EMC79823.1 - 0.092 12.8 0.0 0.11 12.6 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Integrase_H2C2 PF17921.1 EMC79823.1 - 0.15 12.2 0.1 0.27 11.4 0.1 1.4 1 0 0 1 1 1 0 Integrase zinc binding domain DUF948 PF06103.11 EMC79823.1 - 4.7 7.5 5.2 0.34 11.2 0.3 1.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) UCH PF00443.29 EMC79824.1 - 1.9e-18 66.9 0.0 3.5e-18 66.0 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EMC79824.1 - 1.6e-05 25.1 0.4 3.1e-05 24.2 0.4 1.5 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein SapA PF02199.15 EMC79825.1 - 5.9e-13 48.9 4.6 1.2e-12 47.8 4.6 1.5 1 0 0 1 1 1 1 Saposin A-type domain MspA PF09203.11 EMC79825.1 - 0.088 12.7 20.6 0.14 12.0 4.1 3.4 1 1 2 3 3 3 0 MspA OMP_b-brl_2 PF13568.6 EMC79825.1 - 1.5 8.8 3.0 5.5 7.0 0.2 2.6 2 0 0 2 2 2 0 Outer membrane protein beta-barrel domain Toxin_23 PF08093.11 EMC79826.1 - 5 7.4 12.6 6.9 6.9 1.2 3.3 3 0 0 3 3 3 0 Magi 5 toxic peptide family CLN5 PF15014.6 EMC79826.1 - 6.2 6.4 6.7 19 4.8 0.7 2.2 1 1 1 2 2 2 0 Ceroid-lipofuscinosis neuronal protein 5 SNRNP27 PF08648.12 EMC79827.1 - 5.6e-29 100.0 1.6 1.1e-28 99.0 1.6 1.5 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins Moulting_cycle PF04870.16 EMC79827.1 - 2.6 7.2 9.6 3.4 6.8 9.6 1.1 1 0 0 1 1 1 0 Moulting cycle DUF4662 PF15578.6 EMC79827.1 - 5 6.8 9.2 5.4 6.7 9.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4662) BNIP3 PF06553.12 EMC79827.1 - 8.7 6.0 11.3 1.1 8.9 7.2 1.5 1 1 1 2 2 2 0 BNIP3 Hexokinase_2 PF03727.16 EMC79828.1 - 1.6e-173 574.5 0.3 6.9e-87 290.9 0.1 2.2 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.21 EMC79828.1 - 2.7e-111 370.2 0.5 3.1e-72 242.7 0.0 2.3 2 0 0 2 2 2 2 Hexokinase BTB PF00651.31 EMC79829.1 - 3.2e-14 53.1 0.0 6.8e-13 48.8 0.0 2.5 2 1 1 3 3 3 1 BTB/POZ domain BACK PF07707.15 EMC79829.1 - 2.1e-07 31.0 0.5 5.7e-07 29.6 0.5 1.8 1 0 0 1 1 1 1 BTB And C-terminal Kelch Annexin PF00191.20 EMC79830.1 - 3.8e-97 318.4 6.8 1.3e-24 86.1 0.1 4.0 4 0 0 4 4 4 4 Annexin BMP2K_C PF15282.6 EMC79831.1 - 6.6e-30 104.8 19.5 4.5e-23 82.4 7.4 4.2 3 1 1 4 4 4 2 BMP-2-inducible protein kinase C-terminus RFamide_26RFa PF11109.8 EMC79832.1 - 1.2e-30 106.7 1.0 1.5e-30 106.4 1.0 1.1 1 0 0 1 1 1 1 Orexigenic neuropeptide Qrfp/P518 Fibrinogen_C PF00147.18 EMC79833.1 - 4.4e-11 43.0 0.0 6.6e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Snapin_Pallidin PF14712.6 EMC79833.1 - 0.0092 16.4 4.1 0.071 13.5 0.3 2.4 2 0 0 2 2 2 1 Snapin/Pallidin CENP-F_leu_zip PF10473.9 EMC79833.1 - 0.035 14.1 2.5 0.054 13.5 2.5 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 EMC79833.1 - 0.063 13.3 1.5 7.6 6.6 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) ATG16 PF08614.11 EMC79833.1 - 0.067 13.4 3.7 0.1 12.8 3.7 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) PI_PP_I PF18363.1 EMC79833.1 - 0.069 13.3 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Phosphoinositide phosphatase insertion domain COLFI PF01410.18 EMC79833.1 - 0.13 11.6 0.0 0.29 10.4 0.0 1.5 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain EF-hand_7 PF13499.6 EMC79834.1 - 0.0013 19.1 0.0 0.0019 18.6 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EMC79834.1 - 0.0037 16.7 3.4 0.14 11.8 0.7 2.8 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EMC79834.1 - 0.0049 16.7 0.1 0.079 12.9 0.1 2.5 3 0 0 3 3 3 1 EF-hand domain UPF0154 PF03672.13 EMC79834.1 - 0.019 15.0 1.2 0.03 14.3 1.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) TOPRIM_C PF16898.5 EMC79834.1 - 0.077 13.3 0.2 0.1 12.9 0.2 1.1 1 0 0 1 1 1 0 C-terminal associated domain of TOPRIM PAP2 PF01569.21 EMC79836.1 - 7.4e-14 51.7 3.9 1.1e-13 51.1 3.9 1.2 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 EMC79836.1 - 0.0013 18.5 8.0 0.0037 17.0 8.0 1.8 1 1 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.6 EMC79836.1 - 0.027 15.0 0.6 0.027 15.0 0.6 1.6 2 0 0 2 2 2 0 PAP2 superfamily C-terminal Zip PF02535.22 EMC79836.1 - 0.48 9.6 6.4 5.5 6.1 6.4 2.1 1 1 0 1 1 1 0 ZIP Zinc transporter BAT2_N PF07001.11 EMC79837.1 - 7.9e-67 225.5 9.7 7.9e-67 225.5 9.7 8.2 7 2 3 10 10 10 1 BAT2 N-terminus PMT PF02366.18 EMC79838.1 - 1.3e-90 303.3 23.0 1.3e-90 303.3 23.0 2.1 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EMC79838.1 - 2.9e-53 180.4 11.6 2.9e-53 180.4 11.6 2.8 2 1 1 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EMC79838.1 - 2.7e-12 46.9 0.0 4.9e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 MIR domain HPP PF04982.13 EMC79838.1 - 0.05 13.8 0.6 0.05 13.8 0.6 3.5 4 0 0 4 4 4 0 HPP family IL34 PF15036.6 EMC79838.1 - 0.11 12.5 0.3 0.19 11.8 0.3 1.3 1 0 0 1 1 1 0 Interleukin 34 PRK PF00485.18 EMC79839.1 - 1.8e-35 122.5 0.3 2.4e-35 122.1 0.3 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family CD225 PF04505.12 EMC79840.1 - 2.8e-20 72.2 0.5 3.7e-20 71.8 0.5 1.2 1 0 0 1 1 1 1 Interferon-induced transmembrane protein DUF4234 PF14018.6 EMC79840.1 - 0.011 15.9 0.1 4 7.6 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4234) DUF4190 PF13828.6 EMC79840.1 - 0.015 15.0 0.2 0.015 15.0 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4190) Med27 PF11571.8 EMC79841.1 - 9.4e-28 96.4 0.2 1.8e-27 95.5 0.2 1.5 1 0 0 1 1 1 1 Mediator complex subunit 27 Laminin_N PF00055.17 EMC79842.1 - 1.4e-49 168.8 0.0 1.4e-49 168.8 0.0 3.3 3 1 1 4 4 4 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.24 EMC79842.1 - 3.3e-21 75.2 68.1 3.7e-09 36.6 14.0 4.7 3 1 1 4 4 4 3 Laminin EGF domain EGF PF00008.27 EMC79842.1 - 0.0017 18.6 7.6 0.0017 18.6 7.6 5.6 4 2 2 6 6 6 2 EGF-like domain BNR PF02012.20 EMC79842.1 - 0.012 15.5 1.1 1.5 9.2 0.0 3.2 2 0 0 2 2 2 0 BNR/Asp-box repeat AAA_11 PF13086.6 EMC79843.1 - 2.7e-68 230.6 2.9 2.7e-68 230.6 2.9 4.4 3 1 0 3 3 2 1 AAA domain AAA_12 PF13087.6 EMC79843.1 - 7.2e-54 182.4 0.1 1.8e-53 181.1 0.1 1.8 1 0 0 1 1 1 1 AAA domain SEN1_N PF12726.7 EMC79843.1 - 4.6e-14 51.6 1.3 1.8e-13 49.7 1.3 1.9 1 1 0 1 1 1 1 SEN1 N terminal AAA_19 PF13245.6 EMC79843.1 - 2.4e-10 40.9 0.0 2.2e-09 37.8 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EMC79843.1 - 4.1e-10 39.7 0.8 0.00099 18.9 0.0 3.2 3 0 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 EMC79843.1 - 2.5e-07 30.7 0.6 0.12 12.1 0.0 3.8 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 EMC79843.1 - 1.4e-05 25.4 0.8 0.00015 22.0 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_16 PF13191.6 EMC79843.1 - 0.00036 21.0 0.1 0.0015 18.9 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain ResIII PF04851.15 EMC79843.1 - 0.0012 18.9 0.0 0.0075 16.3 0.0 2.4 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 EMC79843.1 - 0.0047 16.2 0.1 0.14 11.4 0.0 2.5 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.14 EMC79843.1 - 0.039 13.8 0.0 0.22 11.3 0.0 2.3 2 0 0 2 2 2 0 Helicase STAT_alpha PF01017.20 EMC79843.1 - 0.081 12.8 3.3 0.44 10.4 3.3 2.4 1 0 0 1 1 1 0 STAT protein, all-alpha domain OmpH PF03938.14 EMC79843.1 - 1.7 9.0 6.6 8.2 6.8 6.6 2.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Myb_DNA-bind_6 PF13921.6 EMC79844.1 - 3.6e-16 59.1 6.7 2.3e-13 50.2 0.3 3.7 4 0 0 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EMC79844.1 - 2e-14 53.5 11.1 2e-08 34.3 0.1 3.6 4 1 0 4 4 4 2 Myb-like DNA-binding domain Poxvirus_B22R_N PF13169.6 EMC79844.1 - 0.034 14.6 0.5 0.3 11.6 0.1 2.5 2 0 0 2 2 2 0 Poxvirus B22R protein N-terminal Myb_DNA-bind_4 PF13837.6 EMC79844.1 - 0.94 9.9 11.3 13 6.2 5.9 3.7 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain DUF4483 PF14825.6 EMC79845.1 - 1.9e-38 131.7 0.0 2.7e-38 131.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4483) Homeodomain PF00046.29 EMC79846.1 - 1.5e-22 79.2 5.9 2.5e-22 78.5 5.9 1.4 1 0 0 1 1 1 1 Homeodomain Anophelin PF10731.9 EMC79846.1 - 0.014 15.2 0.4 0.024 14.5 0.4 1.4 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito Homeobox_KN PF05920.11 EMC79846.1 - 0.033 14.1 0.2 0.084 12.8 0.2 1.7 1 0 0 1 1 1 0 Homeobox KN domain DEAD PF00270.29 EMC79847.1 - 1e-45 155.6 0.0 2.2e-45 154.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC79847.1 - 1.3e-25 89.8 0.0 6e-25 87.7 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EMC79847.1 - 5.4e-15 55.4 0.1 1.1e-14 54.3 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EMC79847.1 - 1.6e-06 28.2 0.0 3e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EMC79847.1 - 0.00056 19.2 0.1 0.0051 16.1 0.0 2.1 1 1 1 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase FF PF01846.19 EMC79847.1 - 0.0038 17.4 0.2 0.15 12.2 0.0 2.5 2 0 0 2 2 2 1 FF domain Helicase_C_2 PF13307.6 EMC79847.1 - 0.077 13.2 0.1 0.15 12.2 0.1 1.5 1 0 0 1 1 1 0 Helicase C-terminal domain Helicase_RecD PF05127.14 EMC79847.1 - 0.092 12.6 0.0 0.53 10.1 0.0 2.3 3 0 0 3 3 3 0 Helicase SecA_DEAD PF07517.14 EMC79847.1 - 0.16 11.3 0.2 1.1 8.4 0.0 2.1 2 0 0 2 2 2 0 SecA DEAD-like domain AAA_22 PF13401.6 EMC79847.1 - 0.53 10.6 2.1 7.6 6.8 0.3 3.0 2 1 1 3 3 3 0 AAA domain TFIIIC_delta PF12657.7 EMC79848.1 - 1.4e-28 100.1 0.0 5.9e-28 98.1 0.0 2.0 2 0 0 2 2 2 1 Transcription factor IIIC subunit delta N-term zf-TFIIIC PF12660.7 EMC79848.1 - 1.3e-09 37.9 2.0 1.3e-09 37.9 2.0 2.1 2 0 0 2 2 2 1 Putative zinc-finger of transcription factor IIIC complex ADK PF00406.22 EMC79849.1 - 0.0073 16.4 0.1 0.0084 16.2 0.1 1.1 1 0 0 1 1 1 1 Adenylate kinase ADK PF00406.22 EMC79850.1 - 1.3e-41 142.3 0.0 6.5e-24 84.8 0.0 2.4 2 1 0 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 EMC79850.1 - 9.4e-20 71.4 0.0 2e-10 41.2 0.0 2.4 2 1 0 2 2 2 2 AAA domain AAA_33 PF13671.6 EMC79850.1 - 1.5e-12 47.9 0.1 8.8e-08 32.4 0.0 2.8 2 1 1 3 3 3 2 AAA domain AAA_18 PF13238.6 EMC79850.1 - 1.6e-12 48.1 0.0 1.2e-08 35.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain Hydin_ADK PF17213.3 EMC79850.1 - 1.1e-08 35.7 0.0 0.037 14.3 0.0 4.1 3 1 0 4 4 4 2 Hydin Adenylate kinase-like domain AAA PF00004.29 EMC79850.1 - 1.2e-07 32.2 0.1 0.0029 18.0 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EMC79850.1 - 1.8e-05 25.2 0.0 0.062 13.7 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain KTI12 PF08433.10 EMC79850.1 - 5.1e-05 22.8 0.0 0.1 12.0 0.0 2.4 2 0 0 2 2 2 2 Chromatin associated protein KTI12 AAA_22 PF13401.6 EMC79850.1 - 0.00064 20.0 0.0 0.83 9.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain Cytidylate_kin PF02224.18 EMC79850.1 - 0.00089 19.0 0.0 0.048 13.4 0.0 2.2 2 0 0 2 2 2 1 Cytidylate kinase ABC_tran PF00005.27 EMC79850.1 - 0.0013 19.2 0.0 0.57 10.7 0.0 2.3 2 0 0 2 2 2 1 ABC transporter RuvB_N PF05496.12 EMC79850.1 - 0.0014 18.4 0.0 1.8 8.3 0.0 2.3 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EMC79850.1 - 0.0015 18.9 0.1 2.3 8.6 0.0 2.5 2 0 0 2 2 2 2 RNA helicase AAA_19 PF13245.6 EMC79850.1 - 0.0054 17.1 0.0 0.064 13.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EMC79850.1 - 0.0075 16.3 0.1 6.2 6.8 0.0 3.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EMC79850.1 - 0.0095 15.3 0.0 1.4 8.3 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EMC79850.1 - 0.011 15.9 0.0 6 7.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.17 EMC79850.1 - 0.013 15.2 0.0 10 5.8 0.0 3.1 3 0 0 3 3 3 0 Thymidylate kinase AAA_24 PF13479.6 EMC79850.1 - 0.017 14.9 0.0 1.6 8.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain RIIa PF02197.17 EMC79850.1 - 0.017 14.8 0.0 0.054 13.2 0.0 1.8 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit NACHT PF05729.12 EMC79850.1 - 0.019 14.9 0.0 0.72 9.7 0.0 2.6 2 0 0 2 2 2 0 NACHT domain PMBR PF09373.10 EMC79850.1 - 0.025 14.8 0.0 0.79 10.0 0.0 2.3 2 0 0 2 2 2 0 Pseudomurein-binding repeat DUF5586 PF17824.1 EMC79850.1 - 0.055 12.6 0.1 0.1 11.7 0.1 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5586) IstB_IS21 PF01695.17 EMC79850.1 - 0.075 12.8 0.0 5.8 6.6 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein ATP_bind_1 PF03029.17 EMC79850.1 - 0.077 12.8 0.0 1.7 8.4 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DUF3987 PF13148.6 EMC79850.1 - 0.079 12.0 0.4 0.94 8.4 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3987) Dpy-30 PF05186.13 EMC79850.1 - 0.081 12.6 0.1 0.24 11.1 0.1 1.9 2 0 0 2 2 1 0 Dpy-30 motif ResIII PF04851.15 EMC79850.1 - 0.11 12.5 0.0 1.2 9.1 0.0 2.1 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit dNK PF01712.19 EMC79850.1 - 0.11 12.3 0.0 0.36 10.7 0.0 1.9 2 0 0 2 2 2 0 Deoxynucleoside kinase Sigma54_activ_2 PF14532.6 EMC79850.1 - 0.14 12.3 0.0 6.7 6.8 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain APS_kinase PF01583.20 EMC79850.1 - 0.16 11.8 0.0 1.8 8.5 0.0 2.1 2 0 0 2 2 2 0 Adenylylsulphate kinase SPACA9 PF15120.6 EMC79851.1 - 1.6e-78 262.2 2.0 1.8e-78 262.0 2.0 1.0 1 0 0 1 1 1 1 Sperm acrosome-associated protein 9 Allexi_40kDa PF05549.11 EMC79851.1 - 0.024 14.1 0.6 0.031 13.8 0.2 1.5 1 1 1 2 2 2 0 Allexivirus 40kDa protein Binary_toxB_2 PF17475.2 EMC79851.1 - 0.081 12.6 0.0 0.1 12.3 0.0 1.1 1 0 0 1 1 1 0 Clostridial binary toxin B/anthrax toxin PA domain 2 zf-C2H2 PF00096.26 EMC79852.1 - 3.2e-27 93.4 52.2 1.9e-05 24.8 2.2 7.1 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC79852.1 - 2.6e-25 87.6 42.9 8.9e-08 32.2 2.0 7.2 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC79852.1 - 5.9e-19 67.1 50.5 0.001 19.7 1.1 6.8 6 1 1 7 7 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC79852.1 - 7.5e-16 58.0 19.8 0.046 14.0 0.0 6.9 6 0 0 6 6 6 6 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMC79852.1 - 8e-09 35.3 42.0 0.0024 17.8 2.8 6.5 6 0 0 6 6 6 4 C2H2-type zinc finger zf-met PF12874.7 EMC79852.1 - 9e-07 29.1 38.2 0.0074 16.6 0.3 6.5 7 0 0 7 7 6 3 Zinc-finger of C2H2 type Ta0938 PF11494.8 EMC79852.1 - 0.00012 22.3 1.3 0.27 11.5 0.0 2.8 2 1 1 3 3 3 2 Ta0938 zf-CHCC PF10276.9 EMC79852.1 - 0.00089 19.3 9.1 0.43 10.7 0.3 4.4 4 0 0 4 4 4 2 Zinc-finger domain Prok-RING_1 PF14446.6 EMC79852.1 - 0.012 15.6 16.2 8.4 6.4 0.1 6.0 6 0 0 6 6 6 0 Prokaryotic RING finger family 1 zf_C2H2_ZHX PF18387.1 EMC79852.1 - 0.013 15.2 3.3 0.013 15.2 3.3 3.6 3 1 1 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-AN1 PF01428.16 EMC79852.1 - 0.013 15.6 23.2 3.5 7.9 0.2 6.6 6 0 0 6 6 6 0 AN1-like Zinc finger Zn-ribbon_8 PF09723.10 EMC79852.1 - 0.014 15.5 23.4 0.55 10.4 2.5 4.8 3 2 2 5 5 5 0 Zinc ribbon domain HNH_5 PF14279.6 EMC79852.1 - 0.015 15.1 15.6 4 7.4 0.9 6.1 4 2 2 6 6 6 0 HNH endonuclease FYVE PF01363.21 EMC79852.1 - 0.019 15.1 27.0 0.45 10.7 4.2 4.2 1 1 2 3 3 3 0 FYVE zinc finger zinc_ribbon_15 PF17032.5 EMC79852.1 - 0.033 14.9 13.6 1.4 9.8 1.0 3.5 1 1 2 3 3 3 0 zinc-ribbon family zf-C2H2_3rep PF18868.1 EMC79852.1 - 0.069 13.8 20.1 12 6.6 11.8 4.8 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf_UBZ PF18439.1 EMC79852.1 - 0.082 12.5 20.5 6.1 6.5 0.1 5.8 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger XPA_N PF01286.18 EMC79852.1 - 0.11 12.5 19.2 7.4 6.7 0.1 6.2 6 0 0 6 6 6 0 XPA protein N-terminal GAGA PF09237.11 EMC79852.1 - 0.16 11.8 7.0 6.9 6.6 0.1 3.6 2 2 2 4 4 4 0 GAGA factor zf-BED PF02892.15 EMC79852.1 - 0.33 11.0 35.2 0.25 11.4 2.5 5.7 3 1 3 6 6 6 0 BED zinc finger HypA PF01155.19 EMC79852.1 - 0.43 10.6 14.1 8.3 6.5 7.0 3.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA BolA PF01722.18 EMC79852.1 - 0.44 10.9 8.4 3.7 7.9 2.1 3.4 2 1 0 2 2 2 0 BolA-like protein zf-LYAR PF08790.11 EMC79852.1 - 0.46 10.4 25.3 6.2 6.8 1.4 6.6 6 1 0 6 6 6 0 LYAR-type C2HC zinc finger Zn_ribbon_SprT PF17283.2 EMC79852.1 - 0.52 10.3 18.8 4.1 7.4 0.0 4.8 4 1 0 4 4 4 0 SprT-like zinc ribbon domain zf-SNAP50_C PF12251.8 EMC79852.1 - 0.63 9.7 15.7 0.042 13.5 2.5 2.8 1 1 2 3 3 3 0 snRNA-activating protein of 50kDa MW C terminal zf-C2HC_2 PF13913.6 EMC79852.1 - 0.89 9.5 25.1 1.6 8.7 1.0 5.5 6 0 0 6 6 5 0 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.5 EMC79852.1 - 1.7 8.5 29.6 8 6.3 0.1 6.3 6 0 0 6 6 6 0 zinc-finger C2H2-type HNH PF01844.23 EMC79852.1 - 2.4 8.4 22.8 1.9 8.8 0.7 5.5 6 0 0 6 6 6 0 HNH endonuclease PyrI_C PF02748.15 EMC79852.1 - 2.4 8.1 18.6 1.5 8.8 0.1 5.6 4 1 2 6 6 6 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_2 PF12756.7 EMC79852.1 - 2.5 8.5 29.3 3.5 8.0 1.1 5.9 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) Sprouty PF05210.13 EMC79852.1 - 2.6 8.5 12.8 3.9 7.9 0.4 2.9 2 1 0 2 2 2 0 Sprouty protein (Spry) DZR PF12773.7 EMC79852.1 - 4.6 7.3 20.5 1.7e+04 -4.1 20.5 3.5 1 1 0 1 1 0 0 Double zinc ribbon HalOD2 PF18547.1 EMC79852.1 - 5.6 7.0 7.7 29 4.7 0.2 3.5 3 0 0 3 3 3 0 Halobacterial output domain 2 DUF2256 PF10013.9 EMC79852.1 - 7.8 6.7 17.9 46 4.2 0.1 5.8 6 0 0 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2256) ADK_lid PF05191.14 EMC79852.1 - 8.8 6.4 15.3 49 4.0 0.4 4.1 1 1 2 3 3 3 0 Adenylate kinase, active site lid PknG_rubred PF16919.5 EMC79852.1 - 9.3 6.4 7.5 2.9 8.1 0.5 2.6 1 1 1 2 2 2 0 Protein kinase G rubredoxin domain COesterase PF00135.28 EMC79853.1 - 1.9e-155 518.6 0.0 2.3e-155 518.3 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMC79853.1 - 6.9e-07 29.3 0.0 1.6e-06 28.2 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EMC79853.1 - 0.0015 18.0 0.0 0.0025 17.4 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family COesterase PF00135.28 EMC79854.1 - 3.1e-30 105.5 0.2 3.5e-30 105.4 0.2 1.0 1 0 0 1 1 1 1 Carboxylesterase family TraO PF10626.9 EMC79854.1 - 0.048 13.4 0.1 0.067 13.0 0.1 1.2 1 0 0 1 1 1 0 Conjugative transposon protein TraO Tau95 PF09734.9 EMC79855.1 - 1.4e-41 142.6 0.3 3.1e-41 141.4 0.3 1.6 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 EMC79855.1 - 9.6e-20 71.1 0.0 2.6e-19 69.7 0.0 1.8 1 0 0 1 1 1 1 Tau95 Triple barrel domain RasGEF PF00617.19 EMC79857.1 - 2.3e-59 200.5 0.3 3.7e-59 199.9 0.3 1.3 1 0 0 1 1 1 1 RasGEF domain RA PF00788.23 EMC79857.1 - 8.3e-15 55.2 0.0 2.8e-14 53.5 0.0 2.0 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain Acyl-CoA_ox_N PF14749.6 EMC79857.1 - 5.1e-05 23.8 0.7 0.48 11.0 0.1 2.8 2 0 0 2 2 2 2 Acyl-coenzyme A oxidase N-terminal Glyco_transf_6 PF03414.13 EMC79858.1 - 8.3e-141 468.4 0.0 9.6e-141 468.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 6 Glyco_tranf_2_4 PF13704.6 EMC79858.1 - 0.11 13.0 0.0 0.2 12.2 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 PhdYeFM_antitox PF02604.19 EMC79858.1 - 0.14 12.0 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Antitoxin Phd_YefM, type II toxin-antitoxin system SURF6 PF04935.12 EMC79859.1 - 1.5e-37 129.4 65.4 1.5e-37 129.4 65.4 2.1 1 1 1 2 2 2 2 Surfeit locus protein 6 Med22 PF06179.12 EMC79860.1 - 1.6e-37 127.9 4.9 2.2e-37 127.5 4.9 1.2 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex UPRTase PF14681.6 EMC79860.1 - 0.054 12.9 0.0 0.079 12.4 0.0 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase SURF1 PF02104.15 EMC79861.1 - 9.4e-44 149.7 0.0 1.1e-43 149.5 0.0 1.1 1 0 0 1 1 1 1 SURF1 family SURF2 PF05477.11 EMC79862.1 - 7.8e-86 287.6 8.1 8.9e-86 287.4 8.1 1.0 1 0 0 1 1 1 1 Surfeit locus protein 2 (SURF2) SURF4 PF02077.15 EMC79863.1 - 7.9e-128 425.7 7.6 8.8e-128 425.5 7.6 1.0 1 0 0 1 1 1 1 SURF4 family SURF2 PF05477.11 EMC79863.1 - 3.5e-38 131.6 0.0 4.2e-38 131.4 0.0 1.0 1 0 0 1 1 1 1 Surfeit locus protein 2 (SURF2) DoxX PF07681.12 EMC79863.1 - 0.034 14.7 0.2 0.034 14.7 0.2 3.5 4 1 1 5 5 5 0 DoxX Pkinase PF00069.25 EMC79864.1 - 2.8e-32 112.1 1.0 3.3e-32 111.9 1.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC79864.1 - 7.7e-27 94.2 1.7 8.6e-27 94.0 1.7 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMC79864.1 - 0.0067 15.8 0.2 0.0089 15.4 0.2 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EMC79864.1 - 0.012 14.9 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like UME PF08064.13 EMC79865.1 - 0.018 14.9 1.5 0.49 10.3 0.1 3.1 2 2 1 3 3 3 0 UME (NUC010) domain IFRD PF05004.13 EMC79865.1 - 0.019 14.1 1.2 0.61 9.1 0.1 2.2 1 1 1 2 2 2 0 Interferon-related developmental regulator (IFRD) RNase_T PF00929.24 EMC79866.1 - 4.4e-21 76.1 0.2 9.4e-21 75.1 0.0 1.7 2 0 0 2 2 2 1 Exonuclease DNA_pol_A_exo1 PF01612.20 EMC79866.1 - 0.00029 20.6 0.1 0.00085 19.1 0.1 1.7 1 1 0 1 1 1 1 3'-5' exonuclease DUF243 PF03103.17 EMC79866.1 - 0.17 12.2 6.5 1.4 9.3 0.2 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF243) DUF3987 PF13148.6 EMC79866.1 - 1.4 7.9 9.0 0.34 9.9 2.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) Cg6151-P PF10233.9 EMC79867.1 - 3.6e-30 104.6 3.9 4.3e-30 104.3 3.9 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P DUF4191 PF13829.6 EMC79867.1 - 0.047 13.0 2.7 0.05 12.9 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4191) TMEM72 PF16054.5 EMC79867.1 - 0.1 12.3 2.6 0.12 12.0 2.6 1.2 1 0 0 1 1 1 0 Transmembrane protein family 72 COPI_assoc PF08507.10 EMC79867.1 - 0.44 10.6 4.8 1.1 9.3 4.9 1.8 1 1 0 1 1 1 0 COPI associated protein DUF3522 PF12036.8 EMC79868.1 - 2.4e-58 197.5 7.2 2.8e-58 197.3 7.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3522) Oxidored_q5_N PF01059.17 EMC79868.1 - 0.097 12.8 4.9 0.26 11.4 3.3 2.1 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase chain 4, amino terminus FAM163 PF15069.6 EMC79869.1 - 1.1e-66 224.3 0.0 1.2e-66 224.1 0.0 1.0 1 0 0 1 1 1 1 FAM163 family DUF4006 PF13179.6 EMC79869.1 - 0.0072 16.2 0.1 0.012 15.5 0.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF4006) ECSCR PF15820.5 EMC79869.1 - 0.092 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator HCV_NS4a PF01006.20 EMC79869.1 - 1.7 8.4 4.5 3.5 7.5 3.2 2.0 2 0 0 2 2 2 0 Hepatitis C virus non-structural protein NS4a Bromodomain PF00439.25 EMC79871.1 - 3.6e-39 132.7 4.0 2.3e-21 75.6 0.3 2.5 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 EMC79871.1 - 3.5e-29 100.7 0.1 3.5e-29 100.7 0.1 2.4 2 0 0 2 2 2 1 Bromodomain extra-terminal - transcription regulation WD40 PF00400.32 EMC79872.1 - 1.1e-62 206.4 19.9 5e-10 39.8 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC79872.1 - 4.2e-27 94.3 2.0 4.1e-05 23.8 0.1 6.2 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMC79872.1 - 8.7e-15 54.3 4.7 0.0017 17.1 0.1 4.8 1 1 4 5 5 5 4 Nucleoporin Nup120/160 eIF2A PF08662.11 EMC79872.1 - 2.6e-12 47.0 0.1 3.1e-06 27.2 0.0 3.7 1 1 3 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EMC79872.1 - 1.5e-06 27.5 5.1 0.026 13.5 0.8 4.1 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EMC79872.1 - 1.5e-06 27.8 0.1 0.0091 15.3 0.0 3.3 1 1 3 4 4 4 3 WD40-like domain PALB2_WD40 PF16756.5 EMC79872.1 - 6.5e-06 25.3 1.9 2.1 7.2 0.0 4.2 1 1 2 4 4 4 3 Partner and localizer of BRCA2 WD40 domain Frtz PF11768.8 EMC79872.1 - 0.00034 19.1 0.0 0.021 13.1 0.0 2.4 1 1 2 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz VID27 PF08553.10 EMC79872.1 - 0.0077 15.3 0.0 0.11 11.5 0.0 2.6 2 1 1 4 4 4 2 VID27 C-terminal WD40-like domain Hira PF07569.11 EMC79872.1 - 0.018 14.7 1.9 28 4.4 0.0 4.4 3 1 1 4 4 4 0 TUP1-like enhancer of split CDtoxinA PF03498.14 EMC79872.1 - 0.039 13.5 1.2 0.26 10.9 0.1 2.5 1 1 0 2 2 2 0 Cytolethal distending toxin A/C domain SBD PF17882.1 EMC79872.1 - 0.11 12.3 0.1 1.8 8.4 0.0 2.3 2 0 0 2 2 2 0 OAA-family lectin sugar binding domain Nucleoporin_N PF08801.11 EMC79872.1 - 0.14 10.8 5.3 0.32 9.7 1.7 3.0 1 1 1 2 2 2 0 Nup133 N terminal like Hormone_recep PF00104.30 EMC79874.1 - 4.1e-40 137.6 0.0 7e-40 136.8 0.0 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Nuc_recep-AF1 PF11825.8 EMC79874.1 - 5.1e-40 136.1 23.1 7.9e-40 135.5 23.1 1.3 1 0 0 1 1 1 1 Nuclear/hormone receptor activator site AF-1 zf-C4 PF00105.18 EMC79874.1 - 4.1e-32 110.5 16.3 6.8e-32 109.8 16.3 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) BAGE PF08180.11 EMC79875.1 - 0.084 13.0 0.6 0.14 12.3 0.6 1.4 1 0 0 1 1 1 0 B melanoma antigen family Chorion_1 PF01723.16 EMC79875.1 - 0.32 11.0 0.4 0.42 10.6 0.4 1.2 1 0 0 1 1 1 0 Chorion protein Collagen PF01391.18 EMC79876.1 - 7.2e-171 554.1 703.7 1.1e-08 34.7 21.5 22.5 3 1 13 16 16 16 11 Collagen triple helix repeat (20 copies) COLFI PF01410.18 EMC79876.1 - 1.7e-96 322.0 0.0 2.4e-96 321.6 0.0 1.2 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Laminin_G_2 PF02210.24 EMC79876.1 - 0.00018 22.1 0.0 0.0003 21.3 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_3 PF13385.6 EMC79876.1 - 0.0015 18.7 0.0 0.0025 18.0 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_1 PF00054.23 EMC79876.1 - 0.058 13.6 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Laminin G domain OLF PF02191.16 EMC79877.1 - 1.3e-89 300.1 7.5 2.1e-89 299.4 7.5 1.3 1 0 0 1 1 1 1 Olfactomedin-like domain Noelin-1 PF12308.8 EMC79877.1 - 5e-49 164.4 9.1 1.5e-47 159.7 5.2 2.8 3 0 0 3 3 3 1 Neurogenesis glycoprotein Helo_like_N PF17111.5 EMC79877.1 - 0.0014 18.1 0.7 0.0014 18.1 0.7 2.4 1 1 1 2 2 2 1 Fungal N-terminal domain of STAND proteins zf-C4H2 PF10146.9 EMC79877.1 - 0.0037 17.6 0.9 0.0054 17.1 0.9 1.3 1 0 0 1 1 1 1 Zinc finger-containing protein GCP_C_terminal PF04130.13 EMC79877.1 - 0.013 15.0 2.3 0.022 14.2 2.3 1.3 1 0 0 1 1 1 0 Gamma tubulin complex component C-terminal Baculo_PEP_C PF04513.12 EMC79877.1 - 0.013 15.5 2.2 0.17 11.9 2.2 2.3 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Lipoprotein_7 PF01540.16 EMC79877.1 - 0.021 14.2 2.7 0.03 13.6 2.7 1.2 1 0 0 1 1 1 0 Adhesin lipoprotein Exonuc_VII_L PF02601.15 EMC79877.1 - 0.075 12.6 5.4 0.13 11.8 5.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.9 EMC79877.1 - 0.076 12.1 8.7 0.15 11.1 8.7 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 NPV_P10 PF05531.12 EMC79877.1 - 0.08 13.4 3.5 6 7.4 3.5 3.2 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF4795 PF16043.5 EMC79877.1 - 0.087 12.4 11.8 0.43 10.1 11.6 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) Xpo1 PF08389.12 EMC79877.1 - 0.088 12.9 1.8 0.11 12.6 0.4 1.7 1 1 0 1 1 1 0 Exportin 1-like protein TBCC_N PF16752.5 EMC79877.1 - 0.097 13.1 12.4 0.085 13.3 8.4 2.4 1 1 2 3 3 3 0 Tubulin-specific chaperone C N-terminal domain APG17 PF04108.12 EMC79877.1 - 0.1 11.7 10.2 0.2 10.7 10.2 1.4 1 1 0 1 1 1 0 Autophagy protein Apg17 DUF1664 PF07889.12 EMC79877.1 - 0.19 11.7 9.3 2.3 8.2 4.5 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Syntaxin_2 PF14523.6 EMC79877.1 - 0.25 11.8 10.6 1.9 8.9 1.3 2.6 1 1 1 2 2 2 0 Syntaxin-like protein FUSC PF04632.12 EMC79877.1 - 0.42 9.1 3.7 0.59 8.6 3.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family CENP-Q PF13094.6 EMC79877.1 - 0.46 10.7 13.1 1.2 9.3 13.1 1.7 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit BLOC1_2 PF10046.9 EMC79877.1 - 0.61 10.4 15.0 0.16 12.3 1.4 3.7 2 1 2 4 4 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 MitMem_reg PF13012.6 EMC79877.1 - 0.62 10.5 3.6 3.6 8.1 3.6 2.1 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function Csm2_III-A PF03750.13 EMC79877.1 - 0.8 10.6 8.6 5.2 7.9 4.3 2.4 1 1 1 2 2 2 0 Csm2 Type III-A CLZ PF16526.5 EMC79877.1 - 0.95 9.9 14.8 2.6 8.5 4.5 3.4 2 2 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels PriC PF07445.12 EMC79877.1 - 1 9.3 13.7 0.55 10.1 7.3 2.2 2 0 0 2 2 2 0 Primosomal replication protein priC Bacillus_HBL PF05791.11 EMC79877.1 - 1 9.1 6.9 7 6.4 2.6 2.3 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) H-kinase_dim PF02895.14 EMC79877.1 - 1.4 9.3 7.3 40 4.7 7.3 2.8 1 1 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain ABC_tran_CTD PF16326.5 EMC79877.1 - 1.5 9.1 15.5 0.59 10.4 2.8 3.7 1 1 2 3 3 3 0 ABC transporter C-terminal domain Laminin_II PF06009.12 EMC79877.1 - 1.6 8.8 9.1 0.67 10.0 3.7 2.4 1 1 1 2 2 2 0 Laminin Domain II DUF2203 PF09969.9 EMC79877.1 - 3.8 8.2 10.8 3.4 8.4 0.9 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Fib_alpha PF08702.10 EMC79877.1 - 4 7.6 11.3 1.8 8.7 5.4 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DASH_Dad3 PF08656.10 EMC79877.1 - 4.9 7.3 10.4 6.3 7.0 0.4 3.8 2 1 2 4 4 3 0 DASH complex subunit Dad3 Occludin_ELL PF07303.13 EMC79877.1 - 5.4 7.8 13.5 24 5.7 0.6 2.7 1 1 1 2 2 2 0 Occludin homology domain FapA PF03961.13 EMC79877.1 - 6.7 5.2 11.1 1.8 7.1 6.0 1.9 1 1 1 2 2 2 0 Flagellar Assembly Protein A PCRF PF03462.18 EMC79877.1 - 7.1 6.4 13.1 2 8.2 5.3 2.2 1 1 1 2 2 2 0 PCRF domain Nup54 PF13874.6 EMC79877.1 - 7.9 6.6 12.7 4.6 7.3 9.3 2.2 1 1 2 3 3 3 0 Nucleoporin complex subunit 54 Spectrin PF00435.21 EMC79877.1 - 8.1 7.0 12.5 3.8e+03 -1.6 12.5 2.5 1 1 0 1 1 1 0 Spectrin repeat TMPIT PF07851.13 EMC79877.1 - 9.7 5.3 11.2 2.8 7.1 6.0 2.0 1 1 1 2 2 2 0 TMPIT-like protein PPP1R26_N PF15740.5 EMC79878.1 - 0 1039.7 54.4 0 1035.8 54.4 1.9 1 1 0 1 1 1 1 Protein phosphatase 1 regulatory subunit 26 N-terminus WHEP-TRS PF00458.20 EMC79878.1 - 0.074 13.2 5.9 6.3 7.0 2.0 3.4 3 0 0 3 3 3 0 WHEP-TRS domain Acyltransferase PF01553.21 EMC79879.1 - 1.6e-35 121.7 0.0 2e-35 121.3 0.0 1.1 1 0 0 1 1 1 1 Acyltransferase Exo_endo_phos PF03372.23 EMC79881.1 - 3.9e-09 36.4 0.1 7.6e-09 35.4 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Peptidase_M16_C PF05193.21 EMC79882.1 - 4.2e-42 144.2 0.0 7.5e-42 143.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EMC79882.1 - 8.1e-40 136.2 0.0 2e-39 135.0 0.0 1.6 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) DUF2695 PF10905.8 EMC79882.1 - 0.019 15.2 0.0 0.044 14.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2695) ERM PF00769.19 EMC79883.1 - 0.011 15.6 15.9 0.012 15.4 15.9 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Tropomyosin PF00261.20 EMC79883.1 - 0.019 14.3 20.8 0.37 10.1 20.6 2.3 1 1 0 1 1 1 0 Tropomyosin Monooxygenase_B PF04744.12 EMC79883.1 - 0.029 13.2 0.7 0.032 13.1 0.7 1.1 1 0 0 1 1 1 0 Monooxygenase subunit B protein GAS PF13851.6 EMC79883.1 - 0.037 13.4 21.8 0.048 13.0 21.8 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding AP1AR PF15745.5 EMC79883.1 - 0.053 13.1 9.7 0.064 12.9 9.7 1.2 1 0 0 1 1 1 0 AP-1 complex-associated regulatory protein LNP1 PF15419.6 EMC79883.1 - 0.061 13.6 6.8 0.092 13.0 6.8 1.3 1 0 0 1 1 1 0 Leukemia NUP98 fusion partner 1 DUF724 PF05266.14 EMC79883.1 - 0.19 11.6 15.4 0.32 10.8 15.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) HMMR_C PF15908.5 EMC79883.1 - 0.79 10.0 17.1 6.3 7.0 6.8 2.2 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor C-terminal V_ATPase_I PF01496.19 EMC79883.1 - 0.91 7.4 11.2 0.97 7.3 11.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLZ PF16526.5 EMC79883.1 - 1.8 9.0 14.8 1.3 9.4 10.2 2.9 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TPR_MLP1_2 PF07926.12 EMC79883.1 - 2.3 8.3 26.2 3.5 7.7 24.9 1.9 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF2514 PF10721.9 EMC79883.1 - 2.5 8.1 10.2 1.7 8.7 7.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2514) Jnk-SapK_ap_N PF09744.9 EMC79883.1 - 3.4 7.9 22.3 6.8 6.9 19.8 1.9 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 HAUS-augmin3 PF14932.6 EMC79883.1 - 3.9 7.0 21.3 3.1 7.3 18.5 1.9 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 DUF5094 PF17015.5 EMC79883.1 - 4.8 7.3 17.1 13 5.8 14.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF5094) zf-DNL PF05180.12 EMC79885.1 - 6.1e-28 96.6 0.1 7.3e-28 96.3 0.1 1.1 1 0 0 1 1 1 1 DNL zinc finger GoLoco PF02188.17 EMC79886.1 - 2.2e-41 138.8 27.3 2.3e-11 42.9 0.7 4.5 4 0 0 4 4 4 4 GoLoco motif TPR_12 PF13424.6 EMC79886.1 - 2.2e-39 133.6 28.3 1.6e-09 37.9 0.9 5.9 4 2 2 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.28 EMC79886.1 - 8.8e-35 117.1 32.1 2.2e-05 24.1 0.0 8.8 10 0 0 10 10 9 7 Tetratricopeptide repeat TPR_7 PF13176.6 EMC79886.1 - 5.7e-30 101.1 19.8 5.6e-06 26.0 0.3 8.7 9 0 0 9 9 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 EMC79886.1 - 4.8e-21 73.2 26.0 0.0054 16.8 0.1 8.7 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 EMC79886.1 - 1.8e-19 68.2 31.3 0.002 18.1 0.1 9.0 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_10 PF13374.6 EMC79886.1 - 2.4e-19 68.5 18.8 0.00053 19.8 0.0 8.3 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_14 PF13428.6 EMC79886.1 - 5.6e-07 29.9 5.3 29 5.8 0.0 7.6 4 3 3 7 7 7 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EMC79886.1 - 2.9e-06 26.9 7.7 0.08 12.3 5.3 2.9 2 1 0 2 2 2 2 MalT-like TPR region TPR_4 PF07721.14 EMC79886.1 - 2.8e-05 24.3 4.3 17 6.4 0.0 6.4 7 0 0 7 7 5 0 Tetratricopeptide repeat Rapsyn_N PF10579.9 EMC79886.1 - 0.00014 21.8 1.8 3.2 7.9 0.0 4.7 3 2 2 5 5 5 2 Rapsyn N-terminal myristoylation and linker region TPR_16 PF13432.6 EMC79886.1 - 0.0002 21.9 13.6 0.096 13.4 0.1 7.1 4 2 1 7 7 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMC79886.1 - 0.00074 19.2 23.5 0.16 11.7 0.2 7.8 7 3 0 7 7 6 1 TPR repeat UreE_C PF05194.12 EMC79886.1 - 0.093 13.2 0.9 7.1 7.2 0.1 3.0 2 1 1 3 3 2 0 UreE urease accessory protein, C-terminal domain FliJ PF02050.16 EMC79886.1 - 0.19 11.9 3.8 0.75 10.0 0.2 3.2 2 2 1 3 3 3 0 Flagellar FliJ protein TPR_17 PF13431.6 EMC79886.1 - 0.46 11.0 16.0 21 5.8 0.0 6.4 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMC79886.1 - 1.2 9.9 8.2 1.8e+02 3.1 0.1 6.4 7 1 0 7 7 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC79886.1 - 6.1 7.2 15.1 28 5.0 0.0 4.7 3 2 3 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 CENP-K PF11802.8 EMC79887.1 - 2.7 7.5 11.8 7.3 6.1 5.4 2.0 1 1 1 2 2 2 0 Centromere-associated protein K QSOX_Trx1 PF18108.1 EMC79888.1 - 8.2e-45 151.4 0.0 1.5e-44 150.5 0.0 1.5 1 0 0 1 1 1 1 QSOX Trx-like domain FAD_SOX PF18371.1 EMC79888.1 - 7.3e-43 145.2 0.2 4.6e-42 142.6 0.0 2.5 2 0 0 2 2 2 1 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase Evr1_Alr PF04777.13 EMC79888.1 - 1.4e-27 96.1 0.3 4.3e-27 94.5 0.3 1.9 1 0 0 1 1 1 1 Erv1 / Alr family Thioredoxin PF00085.20 EMC79888.1 - 0.0061 16.5 0.0 0.061 13.3 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin eIF-5_eIF-2B PF01873.17 EMC79888.1 - 0.13 12.1 0.0 0.41 10.5 0.0 1.8 1 0 0 1 1 1 0 Domain found in IF2B/IF5 Peptidase_A22B PF04258.13 EMC79888.1 - 0.19 11.2 2.1 0.16 11.5 0.6 1.6 2 0 0 2 2 2 0 Signal peptide peptidase Zn-ribbon_8 PF09723.10 EMC79888.1 - 0.47 10.6 3.3 10 6.3 0.4 2.7 2 0 0 2 2 2 0 Zinc ribbon domain Homeodomain PF00046.29 EMC79889.1 - 2.8e-21 75.1 2.1 4.8e-21 74.3 2.1 1.4 1 0 0 1 1 1 1 Homeodomain LIM PF00412.22 EMC79889.1 - 1.5e-15 57.2 11.8 2e-13 50.3 11.7 2.3 2 0 0 2 2 2 2 LIM domain Homeobox_KN PF05920.11 EMC79889.1 - 0.00014 21.7 0.1 0.00042 20.2 0.1 1.9 1 0 0 1 1 1 1 Homeobox KN domain Furin-like_2 PF15913.5 EMC79889.1 - 0.038 14.1 4.2 0.072 13.3 4.2 1.4 1 0 0 1 1 1 0 Furin-like repeat, cysteine-rich DUF5533 PF17685.1 EMC79890.1 - 3.5e-81 270.4 11.4 3.9e-81 270.3 11.4 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5533) CAMSAP_CKK PF08683.11 EMC79893.1 - 5.9e-55 184.5 0.1 1.1e-54 183.6 0.1 1.5 1 0 0 1 1 1 1 Microtubule-binding calmodulin-regulated spectrin-associated CAMSAP_CH PF11971.8 EMC79893.1 - 1.6e-34 117.6 0.3 3.8e-34 116.4 0.3 1.7 1 0 0 1 1 1 1 CAMSAP CH domain CAMSAP_CC1 PF17095.5 EMC79893.1 - 3.7e-24 84.3 5.9 3.7e-24 84.3 5.9 2.9 2 1 1 3 3 3 1 Spectrin-binding region of Ca2+-Calmodulin M_domain PF12938.7 EMC79893.1 - 0.035 13.9 0.1 0.035 13.9 0.1 2.4 4 0 0 4 4 4 0 M domain of GW182 CH PF00307.31 EMC79893.1 - 0.064 13.4 0.0 0.17 12.1 0.0 1.8 1 0 0 1 1 1 0 Calponin homology (CH) domain Galactosyl_T PF01762.21 EMC79894.1 - 1.1e-39 136.3 0.0 1.5e-39 135.9 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 EMC79894.1 - 1.1e-07 31.6 0.0 1.9e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Fringe-like Proteasom_PSMB PF10508.9 EMC79895.1 - 6.7e-176 585.6 0.0 7.5e-176 585.5 0.0 1.0 1 0 0 1 1 1 1 Proteasome non-ATPase 26S subunit RICTOR_V PF14668.6 EMC79895.1 - 3.9e-06 27.0 0.1 0.55 10.5 0.0 3.9 3 1 2 5 5 5 2 Rapamycin-insensitive companion of mTOR, domain 5 HEAT_2 PF13646.6 EMC79895.1 - 0.00018 21.8 0.0 0.088 13.2 0.0 3.9 3 2 1 4 4 4 1 HEAT repeats Cnd1 PF12717.7 EMC79895.1 - 0.035 14.2 0.0 18 5.4 0.0 2.8 2 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_C PF11698.8 EMC79895.1 - 0.066 13.3 0.0 15 5.8 0.0 3.2 3 0 0 3 3 3 0 V-ATPase subunit H RTTN_N PF14726.6 EMC79895.1 - 0.093 13.5 0.0 8.8 7.2 0.0 3.0 2 0 0 2 2 2 0 Rotatin, an armadillo repeat protein, centriole functioning STAG PF08514.11 EMC79895.1 - 0.097 12.6 0.0 0.68 9.9 0.0 2.3 2 0 0 2 2 2 0 STAG domain Neurochondrin PF05536.11 EMC79895.1 - 0.12 10.7 0.6 5.2 5.3 0.1 2.7 1 1 1 3 3 3 0 Neurochondrin CutA1 PF03091.15 EMC79896.1 - 1.3e-30 105.2 0.0 1.6e-30 104.9 0.0 1.1 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein PHD PF00628.29 EMC79897.1 - 5.2e-15 55.1 18.3 6.6e-10 38.7 1.9 2.5 2 0 0 2 2 2 2 PHD-finger Tudor_2 PF18104.1 EMC79897.1 - 3.3e-14 52.3 0.2 7.2e-14 51.2 0.2 1.6 1 0 0 1 1 1 1 Jumonji domain-containing protein 2A Tudor domain PHD_2 PF13831.6 EMC79897.1 - 0.00017 21.0 2.9 0.00017 21.0 2.9 3.6 3 2 0 3 3 3 1 PHD-finger Prok-RING_1 PF14446.6 EMC79897.1 - 0.0015 18.5 1.3 0.0015 18.5 1.3 3.3 4 0 0 4 4 4 1 Prokaryotic RING finger family 1 DUF4537 PF15057.6 EMC79897.1 - 0.0023 18.0 0.0 0.0038 17.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) C1_1 PF00130.22 EMC79897.1 - 0.014 15.3 0.7 0.014 15.3 0.7 3.9 3 1 1 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) LBR_tudor PF09465.10 EMC79897.1 - 0.091 12.6 0.4 0.17 11.7 0.4 1.5 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain TED_complement PF07678.14 EMC79898.1 - 5.7e-87 291.6 0.1 9.9e-87 290.9 0.1 1.4 1 0 0 1 1 1 1 A-macroglobulin TED domain MG4 PF17789.1 EMC79898.1 - 1.1e-29 102.4 0.9 2.3e-28 98.2 0.1 3.2 4 0 0 4 4 4 1 Macroglobulin domain MG4 MG1 PF17790.1 EMC79898.1 - 1.3e-27 96.1 0.3 6.3e-26 90.7 0.1 3.2 2 0 0 2 2 2 1 Macroglobulin domain MG1 A2M_BRD PF07703.14 EMC79898.1 - 6.5e-26 91.4 0.3 4.4e-24 85.4 0.0 3.0 2 0 0 2 2 2 1 Alpha-2-macroglobulin bait region domain A2M PF00207.22 EMC79898.1 - 5.2e-25 87.1 1.9 9.9e-25 86.2 0.0 2.5 3 0 0 3 3 3 1 Alpha-2-macroglobulin family NTR PF01759.21 EMC79898.1 - 1.1e-23 83.0 0.7 2.7e-23 81.8 0.2 1.9 2 0 0 2 2 2 1 UNC-6/NTR/C345C module A2M_recep PF07677.14 EMC79898.1 - 5.2e-21 75.2 0.0 1.6e-20 73.6 0.0 1.9 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain MG2 PF01835.19 EMC79898.1 - 4.2e-13 49.6 0.0 1.7e-12 47.6 0.0 2.1 1 0 0 1 1 1 1 MG2 domain ANATO PF01821.18 EMC79898.1 - 1.8e-08 35.1 8.3 5.3e-08 33.6 8.3 1.9 1 0 0 1 1 1 1 Anaphylotoxin-like domain MG3 PF17791.1 EMC79898.1 - 3.4e-05 24.0 0.0 0.00012 22.3 0.0 2.0 1 0 0 1 1 1 1 Macroglobulin domain MG3 Prenyltrans PF00432.21 EMC79898.1 - 0.0029 17.3 0.1 0.6 9.9 0.0 2.8 2 0 0 2 2 2 1 Prenyltransferase and squalene oxidase repeat PilZ PF07238.14 EMC79898.1 - 0.0085 16.4 0.1 0.85 10.0 0.0 3.2 3 0 0 3 3 3 1 PilZ domain RVT_connect PF06815.13 EMC79898.1 - 0.13 12.5 2.2 0.86 9.9 0.1 2.6 2 0 0 2 2 2 0 Reverse transcriptase connection domain LRR_9 PF14580.6 EMC79899.1 - 7.8e-21 74.3 8.4 3.3e-20 72.3 2.2 4.1 3 1 1 4 4 4 2 Leucine-rich repeat LRR_8 PF13855.6 EMC79899.1 - 3.7e-10 39.4 25.8 5.2e-07 29.3 2.3 4.8 4 1 0 5 5 5 2 Leucine rich repeat LRR_4 PF12799.7 EMC79899.1 - 9.3e-08 32.3 38.1 3.7e-06 27.2 1.1 5.5 4 1 0 6 6 6 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EMC79899.1 - 6.3e-05 22.7 11.7 0.76 10.0 0.1 4.8 4 0 0 4 4 4 3 Leucine Rich repeat LRR_1 PF00560.33 EMC79899.1 - 0.27 11.9 13.6 15 6.6 0.2 5.6 5 0 0 5 5 5 0 Leucine Rich Repeat Ras PF00071.22 EMC79900.1 - 8.2e-61 204.3 0.1 9.5e-61 204.1 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC79900.1 - 2.4e-32 111.6 0.0 3.7e-32 111.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC79900.1 - 1.6e-12 47.2 0.0 2e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC79900.1 - 2.7e-05 23.8 0.0 0.0013 18.3 0.0 2.2 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EMC79900.1 - 4.7e-05 23.4 0.0 8.9e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC79900.1 - 0.0003 20.7 0.1 0.62 9.9 0.0 2.2 1 1 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EMC79900.1 - 0.0013 18.1 0.0 0.0016 17.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 EMC79900.1 - 0.0025 17.6 0.0 0.062 13.1 0.0 2.0 1 1 0 2 2 2 1 Conserved hypothetical ATP binding protein SRPRB PF09439.10 EMC79900.1 - 0.052 13.0 0.0 0.086 12.3 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF1863 PF08937.11 EMC79900.1 - 0.054 13.8 0.0 0.093 13.0 0.0 1.5 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) Septin PF00735.18 EMC79900.1 - 0.08 12.2 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Septin AAA PF00004.29 EMC79900.1 - 0.11 13.0 0.0 0.56 10.6 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EMC79900.1 - 0.14 12.5 0.1 0.46 10.7 0.1 2.0 1 1 0 1 1 1 0 AAA domain Gelsolin PF00626.22 EMC79901.1 - 2.7e-106 347.6 0.1 1.1e-20 73.3 0.0 6.2 6 0 0 6 6 6 6 Gelsolin repeat Lipoprotein_Ltp PF07553.11 EMC79901.1 - 0.0084 16.3 0.1 2.4 8.5 0.1 2.5 2 0 0 2 2 2 2 Host cell surface-exposed lipoprotein CutA1 PF03091.15 EMC79901.1 - 0.31 10.9 1.8 9.2 6.2 0.0 3.4 5 0 0 5 5 5 0 CutA1 divalent ion tolerance protein Band_7 PF01145.25 EMC79902.1 - 3.5e-35 121.6 1.1 4.3e-35 121.3 1.1 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 EMC79902.1 - 0.00015 21.5 0.2 0.00022 21.0 0.2 1.3 1 0 0 1 1 1 1 SPFH domain-Band 7 family GP68 PF17469.2 EMC79902.1 - 0.12 12.8 0.1 0.32 11.4 0.1 1.7 1 0 0 1 1 1 0 Phage protein Gp68 7tm_4 PF13853.6 EMC79904.1 - 6.9e-49 167.1 9.8 8.9e-49 166.7 9.8 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC79904.1 - 9e-30 103.9 15.0 1.6e-29 103.0 15.0 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC79904.1 - 0.002 17.8 6.7 0.002 17.8 6.7 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC79905.1 - 6.6e-41 140.9 14.7 8.2e-41 140.6 14.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC79905.1 - 2.6e-27 95.8 17.9 3.6e-27 95.4 17.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC79906.1 - 8.2e-35 120.9 11.4 2.2e-26 93.3 4.3 2.0 1 1 1 2 2 2 2 Olfactory receptor 7tm_1 PF00001.21 EMC79906.1 - 1.8e-13 50.5 11.5 1.6e-06 27.7 0.2 2.2 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) p450 PF00067.22 EMC79907.1 - 5.2e-12 45.3 0.4 5.4e-12 45.2 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 FA_desaturase PF00487.24 EMC79908.1 - 4.2e-14 53.0 10.1 4.2e-14 53.0 10.1 1.5 1 1 0 1 1 1 1 Fatty acid desaturase Fun_ATP-synt_8 PF05933.13 EMC79908.1 - 0.022 14.9 1.1 0.084 13.0 0.3 2.2 2 0 0 2 2 2 0 Fungal ATP synthase protein 8 (A6L) wnt PF00110.19 EMC79909.1 - 3e-97 325.9 21.7 3.7e-97 325.6 21.7 1.0 1 0 0 1 1 1 1 wnt family NDUF_B8 PF05821.11 EMC79910.1 - 2.3e-66 223.0 9.7 2.6e-66 222.9 9.7 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) Cupin_8 PF13621.6 EMC79911.1 - 3.9e-41 141.5 0.2 5.2e-41 141.0 0.2 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 EMC79911.1 - 2.1e-07 30.7 0.1 3.8e-07 29.9 0.1 1.4 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 EMC79911.1 - 0.041 14.3 0.2 0.18 12.2 0.2 2.1 1 1 0 1 1 1 0 JmjC domain, hydroxylase Cupin_2 PF07883.11 EMC79911.1 - 0.072 12.8 0.0 0.7 9.7 0.0 2.1 2 0 0 2 2 2 0 Cupin domain DUF4342 PF14242.6 EMC79911.1 - 0.16 12.0 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4342) Pax2_C PF12403.8 EMC79913.1 - 7e-41 138.8 19.3 7e-41 138.8 19.3 3.2 3 1 0 3 3 3 1 Paired-box protein 2 C terminal PAX PF00292.18 EMC79913.1 - 1.2e-31 109.3 0.2 2.2e-31 108.4 0.2 1.4 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.6 EMC79913.1 - 0.00088 19.0 0.0 0.0019 18.0 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain Homeodomain PF00046.29 EMC79913.1 - 0.0098 15.7 0.1 0.023 14.5 0.1 1.6 1 0 0 1 1 1 1 Homeodomain HTH_Tnp_IS1 PF12759.7 EMC79913.1 - 0.1 12.2 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 InsA C-terminal domain CUE PF02845.16 EMC79914.1 - 0.0013 18.3 0.1 0.003 17.2 0.1 1.6 1 0 0 1 1 1 1 CUE domain ANTH PF07651.16 EMC79914.1 - 0.042 12.8 0.0 0.075 12.0 0.0 1.3 1 0 0 1 1 1 0 ANTH domain LRR_4 PF12799.7 EMC79915.1 - 1.7e-09 37.8 0.4 0.02 15.3 0.0 5.0 4 2 2 6 6 6 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EMC79915.1 - 1.3e-07 31.1 6.4 0.37 10.9 0.0 6.1 6 0 0 6 6 6 3 Leucine Rich repeat F-box PF00646.33 EMC79915.1 - 1e-05 25.3 0.8 1e-05 25.3 0.8 3.2 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 EMC79915.1 - 0.023 14.6 1.7 0.023 14.6 1.7 2.6 2 0 0 2 2 2 0 F-box-like DUF1699 PF08004.11 EMC79915.1 - 0.052 13.2 0.6 3.4 7.4 0.0 3.2 1 1 0 3 3 3 0 Protein of unknown function (DUF1699) LRR_1 PF00560.33 EMC79915.1 - 7.8 7.5 13.5 13 6.8 0.1 5.5 6 2 0 6 6 6 0 Leucine Rich Repeat PH_9 PF15410.6 EMC79916.1 - 2.4e-37 127.9 0.0 8.4e-37 126.2 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain Sec7 PF01369.20 EMC79916.1 - 1.4e-29 103.1 0.0 2.8e-29 102.1 0.0 1.5 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 EMC79916.1 - 1.3e-12 48.2 0.0 3.2e-12 46.9 0.0 1.8 1 0 0 1 1 1 1 PH domain RHD_DNA_bind PF00554.22 EMC79917.1 - 1.1e-66 223.9 0.1 1.8e-66 223.3 0.1 1.3 1 0 0 1 1 1 1 Rel homology DNA-binding domain RHD_dimer PF16179.5 EMC79917.1 - 2.8e-38 130.1 0.0 4.9e-38 129.3 0.0 1.4 1 0 0 1 1 1 1 Rel homology dimerisation domain Ank_2 PF12796.7 EMC79917.1 - 3.8e-30 104.3 2.2 5.7e-13 49.3 0.3 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC79917.1 - 1.1e-28 96.1 4.7 0.00038 20.7 0.0 6.7 6 0 0 6 6 6 6 Ankyrin repeat Ank PF00023.30 EMC79917.1 - 2e-27 94.4 15.8 3.5e-05 24.1 0.0 6.6 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.6 EMC79917.1 - 9.3e-27 93.1 1.9 2.5e-08 34.3 0.0 5.0 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC79917.1 - 1e-24 86.2 1.2 5.3e-07 29.8 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Death PF00531.22 EMC79917.1 - 0.00083 19.5 0.3 0.0081 16.3 0.0 2.4 2 0 0 2 2 2 1 Death domain Tim44 PF04280.15 EMC79917.1 - 0.13 12.4 0.7 0.24 11.5 0.3 1.6 2 0 0 2 2 2 0 Tim44-like domain Frag1 PF10277.9 EMC79918.1 - 4.1e-35 121.3 7.8 5.1e-35 121.0 7.8 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family VKOR PF07884.14 EMC79918.1 - 0.0085 16.3 4.5 0.018 15.2 4.5 1.6 1 0 0 1 1 1 1 Vitamin K epoxide reductase family DUF998 PF06197.13 EMC79918.1 - 0.019 14.6 8.4 0.028 14.0 8.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF998) DUF2768 PF10966.8 EMC79918.1 - 0.033 14.6 1.6 0.1 13.1 1.6 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2768) Homeodomain PF00046.29 EMC79919.1 - 9.2e-23 79.9 9.4 1.5e-22 79.2 9.4 1.3 1 0 0 1 1 1 1 Homeodomain OAR PF03826.17 EMC79919.1 - 5.2e-08 32.5 0.6 5.2e-08 32.5 0.6 2.3 2 0 0 2 2 2 1 OAR domain Homeobox_KN PF05920.11 EMC79919.1 - 0.0037 17.1 0.6 0.0037 17.1 0.6 2.1 2 0 0 2 2 2 1 Homeobox KN domain Auxin_canalis PF05703.11 EMC79919.1 - 5.5 6.8 10.4 1.1 9.2 6.2 1.8 2 0 0 2 2 2 0 Auxin canalisation UDPGT PF00201.18 EMC79920.1 - 9.7e-108 361.1 0.0 1.1e-107 360.9 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EMC79920.1 - 0.00066 19.7 0.0 0.0014 18.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Pro_3_hydrox_C PF05373.11 EMC79920.1 - 0.1 12.7 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal DBB PF14545.6 EMC79921.1 - 9.2e-53 177.9 0.1 1.5e-52 177.2 0.1 1.4 1 0 0 1 1 1 1 Dof, BCAP, and BANK (DBB) motif, TIR_3 PF18567.1 EMC79921.1 - 2.6e-47 160.1 0.5 6.1e-47 158.9 0.5 1.7 1 0 0 1 1 1 1 Toll/interleukin-1 receptor domain EMP70 PF02990.16 EMC79922.1 - 5.5e-161 536.8 21.0 6.8e-161 536.5 21.0 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 EVC2_like PF12297.8 EMC79922.1 - 0.83 8.3 1.8 15 4.1 0.0 2.1 2 0 0 2 2 2 0 Ellis van Creveld protein 2 like protein Zona_pellucida PF00100.23 EMC79923.1 - 9.1e-56 189.5 0.2 1.2e-55 189.1 0.2 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain Trefoil PF00088.18 EMC79923.1 - 1.5e-09 37.6 6.2 3.9e-09 36.3 6.2 1.8 1 0 0 1 1 1 1 Trefoil (P-type) domain DUF4657 PF15552.6 EMC79924.1 - 9.5e-05 22.1 7.3 9.5e-05 22.1 7.3 2.2 2 1 1 3 3 3 1 Domain of unknown function (DUF4657) DUF4749 PF15936.5 EMC79925.1 - 1.5e-28 99.8 3.9 1.5e-28 99.8 1.9 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4749) PDZ PF00595.24 EMC79925.1 - 4.7e-12 46.1 0.1 1.2e-11 44.7 0.1 1.8 1 0 0 1 1 1 1 PDZ domain LIM PF00412.22 EMC79925.1 - 2.1e-11 43.8 5.3 3.8e-11 43.0 5.3 1.4 1 0 0 1 1 1 1 LIM domain PDZ_6 PF17820.1 EMC79925.1 - 2.4e-07 30.5 0.1 6.9e-07 29.0 0.0 1.9 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 EMC79925.1 - 0.00014 22.1 0.1 0.00032 20.9 0.0 1.7 2 0 0 2 2 2 1 PDZ domain Lar_restr_allev PF14354.6 EMC79925.1 - 0.73 10.2 3.1 1.4 9.3 3.1 1.5 1 0 0 1 1 1 0 Restriction alleviation protein Lar Zn-ribbon_8 PF09723.10 EMC79925.1 - 2.2 8.5 5.4 18 5.5 3.8 2.7 1 1 2 3 3 3 0 Zinc ribbon domain DZR PF12773.7 EMC79925.1 - 3.8 7.6 7.3 4.9 7.3 4.5 2.4 2 1 0 2 2 2 0 Double zinc ribbon SH3_1 PF00018.28 EMC79926.1 - 2.3e-39 132.8 0.5 7.3e-12 44.7 0.0 4.3 4 0 0 4 4 4 3 SH3 domain SH3_9 PF14604.6 EMC79926.1 - 5.8e-39 131.7 0.6 1.5e-14 53.5 0.1 3.8 3 0 0 3 3 3 3 Variant SH3 domain SH3_2 PF07653.17 EMC79926.1 - 1.2e-30 104.9 0.3 2.5e-12 46.3 0.0 3.6 4 0 0 4 4 4 3 Variant SH3 domain Sorb PF02208.16 EMC79926.1 - 2.2e-19 69.0 0.9 6.3e-19 67.6 0.9 1.9 1 0 0 1 1 1 1 Sorbin homologous domain MitMem_reg PF13012.6 EMC79927.1 - 8.5e-24 84.1 0.5 1.5e-23 83.4 0.2 1.6 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EMC79927.1 - 4.4e-16 58.9 0.6 7.5e-16 58.2 0.6 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Annexin PF00191.20 EMC79928.1 - 1.3e-99 326.3 9.7 1.8e-27 95.2 0.6 4.1 4 0 0 4 4 4 4 Annexin Metallophos PF00149.28 EMC79929.1 - 1.3e-37 130.3 0.0 2.1e-37 129.6 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF5378 PF17349.2 EMC79929.1 - 0.00076 18.9 0.1 0.0011 18.3 0.1 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5378) Calsarcin PF05556.11 EMC79931.1 - 1.2e-102 342.9 0.0 1.3e-102 342.7 0.0 1.0 1 0 0 1 1 1 1 Calcineurin-binding protein (Calsarcin) PDZ PF00595.24 EMC79932.1 - 4.6e-11 42.9 0.0 1e-10 41.8 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Calsarcin PF05556.11 EMC79932.1 - 4.9e-11 42.7 5.2 0.0029 17.2 0.1 4.0 2 1 1 4 4 4 3 Calcineurin-binding protein (Calsarcin) PDZ_6 PF17820.1 EMC79932.1 - 1.7e-05 24.6 0.0 3.5e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Sec23_trunk PF04811.15 EMC79933.1 - 3e-90 302.0 0.1 4.3e-90 301.5 0.1 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EMC79933.1 - 1.3e-26 92.4 0.0 2.8e-26 91.3 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EMC79933.1 - 3.1e-19 69.5 0.1 1.9e-18 67.0 0.0 2.2 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EMC79933.1 - 4e-14 52.4 11.5 9e-14 51.2 11.5 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EMC79933.1 - 1.3e-11 44.2 0.0 3.2e-11 43.0 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat Glyco_transf_10 PF00852.19 EMC79934.1 - 2.9e-36 124.8 0.1 4.1e-36 124.3 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 EMC79934.1 - 0.0032 17.9 0.1 0.007 16.8 0.1 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal CHCH PF06747.13 EMC79935.1 - 3.2e-09 36.7 2.6 4.4e-09 36.2 2.6 1.2 1 0 0 1 1 1 1 CHCH domain MTCP1 PF08991.10 EMC79935.1 - 0.00024 21.3 0.5 0.00029 21.0 0.5 1.2 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type UCR_hinge PF02320.16 EMC79935.1 - 0.059 13.6 3.1 0.99 9.7 0.1 2.1 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein SRCR PF00530.18 EMC79936.1 - 1.9e-111 365.2 27.6 5.3e-32 110.3 0.9 4.5 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Trypsin PF00089.26 EMC79936.1 - 2.8e-63 213.7 0.0 4e-63 213.2 0.0 1.2 1 0 0 1 1 1 1 Trypsin SRCR_2 PF15494.6 EMC79936.1 - 1.2e-25 89.8 9.9 1.9e-05 25.1 0.1 4.6 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 EMC79936.1 - 8.2e-10 39.2 0.5 1.2 9.7 0.0 4.6 4 0 0 4 4 4 3 Hepsin, SRCR domain Kringle PF00051.18 EMC79936.1 - 6.8e-09 35.9 0.8 1.6e-08 34.7 0.8 1.7 1 0 0 1 1 1 1 Kringle domain DUF1986 PF09342.11 EMC79936.1 - 0.0014 19.0 0.0 0.003 17.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) SapB_2 PF03489.17 EMC79936.1 - 0.091 12.9 0.0 1.9e+02 2.3 0.0 4.2 4 0 0 4 4 4 0 Saposin-like type B, region 2 Defensin_1 PF00323.19 EMC79936.1 - 0.22 12.1 1.2 3.2 8.4 0.1 3.2 2 0 0 2 2 2 0 Mammalian defensin HSNSD PF12062.8 EMC79937.1 - 1.2e-254 845.6 0.0 1.7e-254 845.1 0.0 1.2 1 0 0 1 1 1 1 heparan sulfate-N-deacetylase Sulfotransfer_1 PF00685.27 EMC79937.1 - 3.7e-45 154.5 0.0 5.5e-45 153.9 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC79937.1 - 7.2e-09 36.3 0.7 0.0046 17.4 0.0 2.5 1 1 1 2 2 2 2 Sulfotransferase family Pkinase PF00069.25 EMC79938.1 - 3.7e-58 197.0 0.0 1.8e-47 161.9 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMC79938.1 - 9.9e-24 84.0 0.0 3.6e-19 69.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC79938.1 - 0.00017 20.5 0.0 0.00032 19.6 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EMC79938.1 - 0.19 11.1 1.1 0.41 10.0 1.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Trypsin PF00089.26 EMC79939.1 - 3e-68 229.9 1.8 3.9e-68 229.6 1.8 1.1 1 0 0 1 1 1 1 Trypsin Kringle PF00051.18 EMC79939.1 - 5e-18 65.2 3.9 1.3e-17 63.8 3.9 1.8 1 0 0 1 1 1 1 Kringle domain Trypsin_2 PF13365.6 EMC79939.1 - 8.8e-06 26.7 0.0 1.5e-05 26.0 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1505 PF07403.11 EMC79939.1 - 0.0078 16.4 2.0 0.03 14.5 2.0 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1505) EGF_2 PF07974.13 EMC79939.1 - 0.0089 16.4 6.3 0.0089 16.4 6.3 3.6 4 0 0 4 4 4 1 EGF-like domain DUF1986 PF09342.11 EMC79939.1 - 0.022 15.1 0.0 0.046 14.1 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1986) DUF316 PF03761.15 EMC79939.1 - 0.024 14.2 0.1 1.4 8.4 0.0 2.2 2 0 0 2 2 2 0 Chymotrypsin family Peptidase-S1 hEGF PF12661.7 EMC79939.1 - 0.053 14.2 3.3 0.67 10.7 3.3 3.1 1 0 0 1 1 1 0 Human growth factor-like EGF Adap_comp_sub PF00928.21 EMC79940.1 - 9e-64 215.4 0.3 9.7e-63 212.0 0.3 2.0 1 1 0 1 1 1 1 Adaptor complexes medium subunit family muHD PF10291.9 EMC79940.1 - 4.1e-05 23.2 0.0 0.00012 21.6 0.0 1.6 1 1 1 2 2 2 1 Muniscin C-terminal mu homology domain Clat_adaptor_s PF01217.20 EMC79940.1 - 0.00015 21.7 0.2 0.00028 20.8 0.2 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain PfkB PF00294.24 EMC79941.1 - 1.8e-77 260.6 0.3 2.1e-77 260.4 0.3 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EMC79941.1 - 0.041 13.3 0.0 0.08 12.3 0.0 1.4 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase Raf1_N PF18578.1 EMC79941.1 - 0.094 13.2 0.5 0.36 11.3 0.2 2.0 2 0 0 2 2 2 0 Rubisco accumulation factor 1 alpha helical domain MOZ_SAS PF01853.18 EMC79942.1 - 1.4e-40 138.8 0.1 1.3e-39 135.7 0.1 2.1 1 1 1 2 2 2 1 MOZ/SAS family zf-MYST PF17772.1 EMC79942.1 - 5.4e-22 77.2 3.9 5.4e-22 77.2 3.9 2.0 2 0 0 2 2 2 1 MYST family zinc finger domain Acetyltransf_7 PF13508.7 EMC79942.1 - 0.021 15.2 0.0 0.14 12.6 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DSPc PF00782.20 EMC79943.1 - 7.1e-31 106.8 0.0 9.9e-31 106.3 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC79943.1 - 0.001 18.7 0.0 0.0015 18.1 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 EMC79943.1 - 0.0021 18.3 0.0 0.0047 17.2 0.0 1.5 1 1 1 2 2 2 1 Rit1 DUSP-like domain DSPn PF14671.6 EMC79943.1 - 0.0029 18.1 0.0 0.0042 17.5 0.0 1.2 1 0 0 1 1 1 1 Dual specificity protein phosphatase, N-terminal half PTPlike_phytase PF14566.6 EMC79943.1 - 0.049 13.7 0.0 0.076 13.1 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate DSPc PF00782.20 EMC79944.1 - 7.2e-27 93.8 0.0 8.6e-27 93.6 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC79944.1 - 0.0002 21.0 0.0 0.00027 20.6 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EMC79945.1 - 5.5e-28 97.4 0.0 6.4e-28 97.2 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC79945.1 - 0.0071 15.9 0.0 0.0094 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EMC79946.1 - 6.8e-27 93.9 0.0 8.1e-27 93.6 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC79946.1 - 0.00083 19.0 0.0 0.0011 18.6 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Myotub-related PF06602.14 EMC79946.1 - 0.021 13.8 0.0 0.026 13.5 0.0 1.1 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain Init_tRNA_PT PF04179.12 EMC79946.1 - 0.054 13.8 0.0 0.11 12.8 0.0 1.5 1 1 0 1 1 1 0 Rit1 DUSP-like domain PAP2_C PF14360.6 EMC79947.1 - 1.5e-27 95.9 10.2 1.5e-27 95.9 10.2 3.0 3 1 0 3 3 3 1 PAP2 superfamily C-terminal SAM_1 PF00536.30 EMC79947.1 - 2.2e-11 44.0 0.0 3.6e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC79947.1 - 4.1e-06 26.8 0.0 8e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PAP2 PF01569.21 EMC79947.1 - 0.0017 18.2 11.4 0.0017 18.2 11.4 2.0 1 1 1 2 2 2 1 PAP2 superfamily SAM_PNT PF02198.16 EMC79947.1 - 0.029 14.3 0.2 0.26 11.3 0.0 2.5 3 0 0 3 3 3 0 Sterile alpha motif (SAM)/Pointed domain PAP2_3 PF14378.6 EMC79947.1 - 0.13 12.0 17.5 0.012 15.4 12.3 1.8 1 1 1 2 2 2 0 PAP2 superfamily Porin_3 PF01459.22 EMC79948.1 - 7.7e-86 287.9 6.0 8.6e-86 287.7 6.0 1.0 1 0 0 1 1 1 1 Eukaryotic porin Methyltransf_3 PF01596.17 EMC79949.1 - 5.6e-71 238.1 0.1 7.1e-71 237.8 0.1 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 EMC79949.1 - 2.9e-13 50.8 0.0 4.3e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC79949.1 - 3.6e-06 26.8 0.0 5.1e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC79949.1 - 3.3e-05 24.5 0.0 6.8e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EMC79949.1 - 0.00021 21.1 0.0 0.00037 20.3 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 EMC79949.1 - 0.0013 18.2 0.0 0.003 16.9 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.7 EMC79949.1 - 0.0091 15.9 0.0 0.058 13.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC79949.1 - 0.016 15.9 0.0 0.035 14.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain LRR_9 PF14580.6 EMC79950.1 - 4.5e-09 36.0 4.9 1e-08 34.9 4.9 1.5 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EMC79950.1 - 4.8e-05 23.6 11.7 0.002 18.5 5.9 3.2 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMC79950.1 - 7.5 6.4 13.5 2.2e+02 1.7 9.4 3.4 2 1 0 2 2 2 0 Leucine rich repeat BK_channel_a PF03493.18 EMC79951.1 - 2e-33 114.4 0.1 4.6e-33 113.3 0.1 1.6 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Ion_trans PF00520.31 EMC79951.1 - 2.8e-17 62.8 17.8 5e-17 61.9 17.8 1.4 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 EMC79951.1 - 1.3e-14 53.9 2.9 3.3e-14 52.6 2.9 1.8 1 0 0 1 1 1 1 Ion channel TrkA_N PF02254.18 EMC79951.1 - 1.5e-05 25.3 0.0 0.00013 22.2 0.0 2.4 2 0 0 2 2 2 1 TrkA-N domain SR-25 PF10500.9 EMC79951.1 - 5.5 6.5 13.0 9.1 5.8 13.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein dbPDZ_assoc PF16610.5 EMC79952.1 - 8.7e-44 147.6 9.6 8.7e-44 147.6 9.6 3.1 2 0 0 2 2 2 1 Unstructured region between two PDZ domains on Dlg5 PDZ PF00595.24 EMC79952.1 - 6.3e-42 141.8 9.8 4.1e-12 46.3 0.0 4.6 4 0 0 4 4 4 4 PDZ domain Takusan PF04822.13 EMC79952.1 - 2.8e-35 120.0 0.5 2.8e-35 120.0 0.5 6.3 4 2 2 6 6 6 1 Takusan PDZ_6 PF17820.1 EMC79952.1 - 1.3e-33 114.5 2.5 2.3e-10 40.1 0.0 4.6 4 0 0 4 4 4 4 PDZ domain PDZ_2 PF13180.6 EMC79952.1 - 1.6e-22 79.6 1.5 9.4e-06 25.9 0.0 4.9 4 0 0 4 4 4 4 PDZ domain Guanylate_kin PF00625.21 EMC79952.1 - 5.3e-14 52.3 0.6 5.3e-14 52.3 0.6 4.1 4 3 0 4 4 4 1 Guanylate kinase SH3_1 PF00018.28 EMC79952.1 - 0.11 12.2 0.0 0.25 11.0 0.0 1.7 1 0 0 1 1 1 0 SH3 domain Peptidase_U32_C PF16325.5 EMC79952.1 - 0.15 12.3 0.4 1.3 9.3 0.0 2.6 2 0 0 2 2 2 0 Peptidase family U32 C-terminal domain RNA_pol_Rpb1_1 PF04997.12 EMC79953.1 - 5.6e-95 318.3 1.5 9.5e-95 317.5 1.5 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 EMC79953.1 - 1.6e-88 296.6 0.2 2.5e-88 296.0 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EMC79953.1 - 5e-75 251.3 0.1 8.9e-75 250.5 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EMC79953.1 - 5.4e-42 143.4 0.0 9.8e-41 139.3 0.0 2.9 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EMC79953.1 - 2.1e-32 111.2 0.0 8.1e-32 109.4 0.0 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Chordopox_RPO7 PF05864.12 EMC79953.1 - 0.45 10.8 2.2 49 4.3 0.1 3.5 3 0 0 3 3 3 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Ribosomal_S24e PF01282.19 EMC79954.1 - 6.9e-46 154.1 0.4 1.3e-45 153.2 0.4 1.5 1 0 0 1 1 1 1 Ribosomal protein S24e ELFV_dehydrog PF00208.21 EMC79955.1 - 5.8e-55 186.7 0.0 8.4e-52 176.3 0.0 2.1 2 0 0 2 2 2 2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 EMC79955.1 - 1.1e-41 141.8 0.0 2.2e-41 140.8 0.0 1.5 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 2-Hacid_dh_C PF02826.19 EMC79955.1 - 0.056 12.8 0.0 0.092 12.1 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain C2 PF00168.30 EMC79956.1 - 3.2e-29 101.3 0.5 7e-16 58.4 0.2 2.2 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.6 EMC79956.1 - 0.0098 15.5 0.1 0.091 12.3 0.1 2.2 2 0 0 2 2 2 1 CEP76 C2 domain MP PF01107.18 EMC79956.1 - 0.042 13.4 0.0 0.085 12.4 0.0 1.4 1 0 0 1 1 1 0 Viral movement protein (MP) ARA70 PF12489.8 EMC79958.1 - 5.1e-66 220.9 35.5 9.3e-39 132.7 6.4 5.9 2 2 2 5 5 5 3 Nuclear coactivator BRK PF07533.16 EMC79958.1 - 0.031 13.9 8.2 0.14 11.8 0.7 3.5 3 0 0 3 3 3 0 BRK domain MRP-63 PF14978.6 EMC79958.1 - 1.2 9.8 5.0 3.5 8.3 0.3 3.0 3 0 0 3 3 3 0 Mitochondrial ribosome protein 63 Tim17 PF02466.19 EMC79959.1 - 8.7e-20 71.2 2.3 9.9e-20 71.0 2.3 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family PARG_cat PF05028.14 EMC79960.1 - 5.3e-113 377.7 0.0 9.8e-113 376.8 0.0 1.5 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) E1_dh PF00676.20 EMC79961.1 - 6.3e-88 294.6 0.1 1.2e-87 293.7 0.1 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component Transket_pyr PF02779.24 EMC79961.1 - 3.2e-67 225.6 0.0 5e-67 225.0 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 EMC79961.1 - 9.3e-55 184.5 0.0 1.7e-54 183.7 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 EMC79961.1 - 1.4e-18 66.2 5.4 1.9e-17 62.5 3.8 2.5 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus GGA_N-GAT PF18308.1 EMC79961.1 - 0.016 14.8 0.0 0.03 13.9 0.0 1.5 1 0 0 1 1 1 0 GGA N-GAT domain Carn_acyltransf PF00755.20 EMC79962.1 - 3.9e-194 646.6 0.0 4.5e-194 646.4 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase LRR_8 PF13855.6 EMC79963.1 - 8.2e-23 79.9 0.4 8.1e-11 41.5 0.0 2.4 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EMC79963.1 - 1.1e-11 44.7 11.5 2.7e-06 27.6 1.5 2.8 1 1 4 5 5 5 4 Leucine Rich repeats (2 copies) I-set PF07679.16 EMC79963.1 - 3.9e-10 39.6 0.0 6.6e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC79963.1 - 6.5e-09 36.3 0.0 1.3e-08 35.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC79963.1 - 4.9e-07 29.8 0.0 1.2e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain fn3 PF00041.21 EMC79963.1 - 6.2e-07 29.7 0.0 2e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 Fibronectin type III domain LRR_1 PF00560.33 EMC79963.1 - 1.5e-05 24.9 1.9 3.8 8.4 0.1 5.0 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_5 PF13306.6 EMC79963.1 - 0.0026 17.7 0.0 0.0048 16.9 0.0 1.3 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) Ig_2 PF13895.6 EMC79963.1 - 0.0069 16.7 0.0 0.015 15.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.6 EMC79963.1 - 0.24 10.9 0.3 1.7 8.1 0.3 1.9 1 1 1 2 2 2 0 Leucine-rich repeat LRR_6 PF13516.6 EMC79963.1 - 3.9 7.8 4.7 9.5 6.6 0.1 3.1 3 0 0 3 3 3 0 Leucine Rich repeat LRR_8 PF13855.6 EMC79964.1 - 6.5e-29 99.5 6.3 2.3e-18 65.7 0.5 2.6 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EMC79964.1 - 3.8e-15 55.7 12.5 1.1e-07 32.1 1.7 3.4 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) Ig_3 PF13927.6 EMC79964.1 - 3.7e-13 49.9 0.0 6.6e-13 49.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC79964.1 - 6.3e-12 45.4 0.0 1.2e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC79964.1 - 1e-07 32.0 0.0 2e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.33 EMC79964.1 - 1.1e-07 31.4 2.3 2 9.3 0.0 5.9 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_5 PF13306.6 EMC79964.1 - 2.4e-06 27.6 0.0 0.00024 21.1 0.0 1.9 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) Ig_2 PF13895.6 EMC79964.1 - 2.6e-06 27.7 0.0 5.6e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRR_6 PF13516.6 EMC79964.1 - 8.2e-05 22.4 7.3 0.1 12.7 0.1 5.2 5 0 0 5 5 5 1 Leucine Rich repeat V-set PF07686.17 EMC79964.1 - 0.0023 18.1 0.1 0.085 13.0 0.1 2.3 1 1 0 1 1 1 1 Immunoglobulin V-set domain LRR_9 PF14580.6 EMC79964.1 - 0.0036 16.8 0.5 0.0076 15.8 0.4 1.4 1 1 0 1 1 1 1 Leucine-rich repeat Bax1-I PF01027.20 EMC79965.1 - 1.7e-39 135.8 14.2 2.5e-39 135.3 14.2 1.3 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 LapA_dom PF06305.11 EMC79966.1 - 0.0054 16.5 0.1 0.0095 15.7 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain DUF3021 PF11457.8 EMC79966.1 - 0.19 12.1 0.1 0.28 11.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3021) DUF4205 PF13898.6 EMC79967.1 - 3.8e-142 473.3 0.0 6.2e-142 472.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4205) Phospho_p8 PF10195.9 EMC79967.1 - 0.26 11.8 7.6 0.13 12.8 4.1 2.2 2 0 0 2 2 2 0 DNA-binding nuclear phosphoprotein p8 UbiA PF01040.18 EMC79968.1 - 2.3e-53 181.1 10.5 2.6e-53 180.9 10.5 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF4018 PF13210.6 EMC79968.1 - 0.034 13.9 0.1 0.085 12.6 0.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4018) Glyco_hydro_79n PF03662.14 EMC79969.1 - 1.2e-25 90.2 0.1 6e-25 87.8 0.1 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 79, N-terminal domain DEAD PF00270.29 EMC79970.1 - 5.8e-16 58.7 1.9 1e-14 54.7 0.1 3.0 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC79970.1 - 1.2e-12 48.1 0.0 4.7e-11 43.0 0.0 3.1 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC79970.1 - 6.7e-09 36.0 0.0 2e-08 34.5 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HHH_5 PF14520.6 EMC79970.1 - 7.3e-06 26.5 0.0 2.7e-05 24.7 0.0 2.0 1 0 0 1 1 1 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.9 EMC79970.1 - 0.0021 17.8 0.0 0.0068 16.2 0.0 1.9 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda DUF4332 PF14229.6 EMC79970.1 - 0.0051 17.0 0.3 0.014 15.6 0.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4332) ScsC_N PF18312.1 EMC79970.1 - 0.0099 15.7 0.2 0.0099 15.7 0.2 2.2 2 0 0 2 2 2 1 Copper resistance protein ScsC N-terminal domain DUF3135 PF11333.8 EMC79970.1 - 0.14 12.4 0.1 0.52 10.6 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3135) FliL PF03748.14 EMC79970.1 - 0.24 12.0 3.5 24 5.6 0.2 3.6 3 0 0 3 3 3 0 Flagellar basal body-associated protein FliL Ribosomal_S18 PF01084.20 EMC79971.1 - 1.7e-22 79.4 0.0 3.6e-22 78.3 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein S18 Rubella_E1 PF05748.11 EMC79971.1 - 0.059 12.3 0.0 0.065 12.1 0.0 1.0 1 0 0 1 1 1 0 Rubella membrane glycoprotein E1 UPF0172 PF03665.13 EMC79972.1 - 0.0036 17.4 2.0 0.0069 16.5 0.0 2.3 2 1 1 3 3 3 1 Uncharacterised protein family (UPF0172) Cluap1 PF10234.9 EMC79972.1 - 0.0046 16.4 0.9 0.0046 16.4 0.9 1.6 2 0 0 2 2 2 1 Clusterin-associated protein-1 DUF16 PF01519.16 EMC79972.1 - 0.047 14.2 0.7 0.047 14.2 0.7 2.1 2 1 0 2 2 2 0 Protein of unknown function DUF16 LMBR1 PF04791.16 EMC79972.1 - 0.048 12.6 1.3 0.062 12.2 1.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein CAMP_factor PF07373.11 EMC79972.1 - 0.081 12.5 0.4 0.15 11.6 0.4 1.3 1 0 0 1 1 1 0 CAMP factor (Cfa) FlaC_arch PF05377.11 EMC79972.1 - 3.2 8.2 5.3 2.3 8.7 2.8 2.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF724 PF05266.14 EMC79972.1 - 6.6 6.5 11.9 1 9.2 2.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Acyltransferase PF01553.21 EMC79973.1 - 3.3e-11 43.0 0.0 5.8e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Acyltransferase PF01553.21 EMC79974.1 - 1.8e-11 43.8 0.0 3.5e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase zf-B_box PF00643.24 EMC79975.1 - 3.9e-07 30.1 14.4 3.9e-07 30.1 14.4 3.6 3 1 0 3 3 3 2 B-box zinc finger CTU2 PF10288.9 EMC79975.1 - 0.11 12.8 0.2 0.11 12.8 0.2 2.6 1 1 1 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 Phage_TAC_3 PF06896.11 EMC79976.1 - 0.03 14.9 2.0 0.051 14.2 2.0 1.4 1 0 0 1 1 1 0 Phage tail assembly chaperone proteins, TAC Thioredoxin_4 PF13462.6 EMC79976.1 - 0.092 12.9 0.5 0.17 12.0 0.5 1.4 1 0 0 1 1 1 0 Thioredoxin SPRY PF00622.28 EMC79976.1 - 0.12 12.5 0.0 0.27 11.4 0.0 1.6 1 0 0 1 1 1 0 SPRY domain DUF612 PF04747.12 EMC79976.1 - 0.36 9.9 3.0 0.53 9.3 3.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF612 zf-RING_UBOX PF13445.6 EMC79977.1 - 3.7e-13 49.2 4.9 3.7e-13 49.2 4.9 3.0 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EMC79977.1 - 9.3e-11 41.7 11.3 9.3e-11 41.7 11.3 3.2 3 1 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 EMC79977.1 - 2.8e-10 39.9 9.6 2.8e-10 39.9 9.6 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC79977.1 - 9.2e-10 38.2 9.8 9.2e-10 38.2 9.8 3.2 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 EMC79977.1 - 2e-09 37.4 1.3 2e-09 37.4 1.3 4.2 5 0 0 5 5 3 1 B-box zinc finger zf-C3HC4_3 PF13920.6 EMC79977.1 - 2.5e-09 36.8 5.5 2.5e-09 36.8 5.5 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC79977.1 - 4.2e-09 36.6 7.8 4.2e-09 36.6 7.8 2.9 3 0 0 3 3 2 1 Ring finger domain zf-RING_5 PF14634.6 EMC79977.1 - 1e-08 35.0 8.2 1e-08 35.0 8.2 3.4 3 1 0 3 3 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC79977.1 - 1.1e-05 25.2 8.0 1.1e-05 25.2 8.0 3.5 3 1 1 4 4 4 1 Prokaryotic RING finger family 4 zf-Nse PF11789.8 EMC79977.1 - 6.5e-05 22.7 4.7 0.00019 21.2 4.7 1.8 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit APG6_N PF17675.1 EMC79977.1 - 9.3e-05 23.0 1.6 9.3e-05 23.0 1.6 1.9 2 0 0 2 2 2 1 Apg6 coiled-coil region zf-ANAPC11 PF12861.7 EMC79977.1 - 0.00058 19.9 1.5 0.00058 19.9 1.5 1.9 2 0 0 2 2 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger U-box PF04564.15 EMC79977.1 - 0.0011 19.1 0.0 0.0033 17.6 0.0 1.8 1 0 0 1 1 1 1 U-box domain CtIP_N PF10482.9 EMC79977.1 - 0.0026 17.8 4.3 0.0078 16.2 4.3 1.8 1 0 0 1 1 1 1 Tumour-suppressor protein CtIP N-terminal domain zf-rbx1 PF12678.7 EMC79977.1 - 0.0041 17.4 6.9 0.0041 17.4 6.9 3.0 2 2 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_6 PF14835.6 EMC79977.1 - 0.0062 16.4 1.6 0.023 14.6 1.6 2.0 1 0 0 1 1 1 1 zf-RING of BARD1-type protein NleF_casp_inhib PF16809.5 EMC79977.1 - 0.015 15.2 2.3 0.033 14.1 2.3 1.6 1 0 0 1 1 1 0 NleF caspase inhibitor Gon7 PF08738.10 EMC79977.1 - 0.022 14.9 2.2 0.07 13.2 1.7 2.0 2 0 0 2 2 2 0 Gon7 family UPF1_Zn_bind PF09416.10 EMC79977.1 - 0.044 13.8 6.0 0.079 12.9 6.0 1.4 1 0 0 1 1 1 0 RNA helicase (UPF2 interacting domain) DUF2383 PF09537.10 EMC79977.1 - 0.051 13.9 2.4 0.089 13.1 2.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) zf-UBR PF02207.20 EMC79977.1 - 0.056 13.6 1.3 0.056 13.6 1.3 3.8 2 2 2 4 4 2 0 Putative zinc finger in N-recognin (UBR box) HrpJ PF07201.11 EMC79977.1 - 0.058 13.7 3.3 0.23 11.8 3.9 1.6 1 1 1 2 2 2 0 HrpJ-like domain ZapB PF06005.12 EMC79977.1 - 0.06 13.8 6.6 0.11 12.9 6.6 1.5 1 0 0 1 1 1 0 Cell division protein ZapB DUF349 PF03993.12 EMC79977.1 - 0.076 13.3 4.3 0.15 12.4 4.3 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) GAGA PF09237.11 EMC79977.1 - 0.098 12.5 3.8 0.61 9.9 1.8 2.7 2 0 0 2 2 2 0 GAGA factor Sec34 PF04136.15 EMC79977.1 - 0.11 12.4 5.9 0.21 11.5 5.9 1.4 1 0 0 1 1 1 0 Sec34-like family UBZ_FAAP20 PF15750.5 EMC79977.1 - 0.23 11.5 0.2 0.23 11.5 0.2 4.1 5 1 1 6 6 4 0 Ubiquitin-binding zinc-finger Jnk-SapK_ap_N PF09744.9 EMC79977.1 - 0.24 11.6 8.3 0.35 11.1 8.3 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Bacillus_HBL PF05791.11 EMC79977.1 - 0.3 10.9 9.3 0.43 10.4 9.3 1.2 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) CHDCT2 PF08074.11 EMC79977.1 - 0.33 11.1 3.3 0.25 11.5 1.8 1.5 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain DUF812 PF05667.11 EMC79977.1 - 0.48 9.2 10.5 0.79 8.5 6.3 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF812) Spc24 PF08286.11 EMC79977.1 - 0.65 10.3 5.9 1.3 9.3 5.9 1.4 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 DUF948 PF06103.11 EMC79977.1 - 0.84 9.9 6.6 1.4 9.2 3.4 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) TMPIT PF07851.13 EMC79977.1 - 0.96 8.6 7.2 1.5 8.0 7.2 1.3 1 0 0 1 1 1 0 TMPIT-like protein zf-UBP_var PF17807.1 EMC79977.1 - 9.5 6.1 14.0 0.081 12.7 1.3 3.2 3 0 0 3 3 3 0 Variant UBP zinc finger Sulfate_transp PF00916.20 EMC79978.1 - 3.5e-131 437.4 16.9 5e-131 436.9 16.9 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EMC79978.1 - 2.8e-28 97.9 0.0 5.1e-28 97.1 0.0 1.5 1 0 0 1 1 1 1 STAS domain Sulfate_transp PF00916.20 EMC79979.1 - 6.7e-117 390.5 16.3 7.4e-117 390.3 15.7 1.4 2 0 0 2 2 2 1 Sulfate permease family STAS PF01740.21 EMC79979.1 - 1.4e-24 85.9 0.0 2.4e-24 85.2 0.0 1.4 1 0 0 1 1 1 1 STAS domain DUF543 PF04418.12 EMC79979.1 - 1.6 8.7 3.6 0.86 9.6 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF543) 7tm_1 PF00001.21 EMC79980.1 - 7.5e-67 225.4 13.5 1e-66 225.0 13.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) F-box PF00646.33 EMC79981.1 - 0.00019 21.2 0.1 0.00058 19.7 0.1 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EMC79981.1 - 0.0027 17.6 0.3 0.0063 16.4 0.3 1.6 1 0 0 1 1 1 1 F-box-like Zip PF02535.22 EMC79981.1 - 9.3 5.4 7.1 26 3.9 7.1 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter IRF PF00605.17 EMC79982.1 - 2.4e-40 137.0 0.6 5.1e-40 136.0 0.6 1.6 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor IL5 PF02025.15 EMC79983.1 - 4.2e-07 30.2 0.0 5.5e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Interleukin 5 AAA_23 PF13476.6 EMC79984.1 - 2.9e-33 116.1 3.5 2.9e-33 116.1 3.5 9.8 1 1 1 3 3 3 1 AAA domain Rad50_zn_hook PF04423.14 EMC79984.1 - 1.3e-12 47.3 0.1 1.3e-12 47.3 0.1 6.2 5 0 0 5 5 5 1 Rad50 zinc hook motif AAA_15 PF13175.6 EMC79984.1 - 1.7e-10 41.2 0.0 1.7e-10 41.2 0.0 5.2 1 1 5 6 6 6 2 AAA ATPase domain AAA_21 PF13304.6 EMC79984.1 - 1.5e-09 38.1 19.7 6e-06 26.3 0.0 4.6 4 2 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EMC79984.1 - 1.3e-06 28.6 0.0 4.4e-06 26.8 0.0 2.0 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit SMC_N PF02463.19 EMC79984.1 - 1e-05 25.1 0.0 1e-05 25.1 0.0 3.0 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain DUF2703 PF10865.8 EMC79984.1 - 0.0061 16.7 0.7 0.0061 16.7 0.7 5.8 4 2 2 6 6 6 1 Domain of unknown function (DUF2703) AAA_29 PF13555.6 EMC79984.1 - 0.0071 16.1 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EMC79984.1 - 0.33 11.3 0.0 0.33 11.3 0.0 5.2 5 3 0 5 5 5 0 AAA ATPase domain AAA_19 PF13245.6 EMC79984.1 - 5.4 7.3 8.0 14 6.0 0.0 4.5 4 1 0 4 4 4 0 AAA domain IL4 PF00727.18 EMC79985.1 - 2e-09 37.6 0.1 3e-09 37.1 0.1 1.3 1 0 0 1 1 1 1 Interleukin 4 IL13 PF03487.13 EMC79985.1 - 0.00027 20.7 0.1 0.00048 19.9 0.1 1.4 1 1 0 1 1 1 1 Interleukin-13 Kinesin PF00225.23 EMC79986.1 - 4.6e-122 407.1 0.1 1.3e-121 405.7 0.1 1.8 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EMC79986.1 - 5.6e-27 94.5 0.1 3.7e-26 91.8 0.0 2.3 2 0 0 2 2 2 1 Microtubule binding CheZ PF04344.13 EMC79986.1 - 0.0036 17.2 6.5 0.0036 17.2 6.5 2.6 3 0 0 3 3 3 1 Chemotaxis phosphatase, CheZ AAA_22 PF13401.6 EMC79986.1 - 0.28 11.4 8.1 1.9 8.8 0.0 3.3 3 1 0 3 3 3 0 AAA domain Cyclin_N PF00134.23 EMC79987.1 - 2.4e-08 33.8 0.1 4.4e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Sema PF01403.19 EMC79987.1 - 0.11 11.2 0.0 0.12 11.2 0.0 1.0 1 0 0 1 1 1 0 Sema domain Septin PF00735.18 EMC79988.1 - 3.2e-96 321.9 2.3 3.2e-96 321.9 2.3 2.0 2 1 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EMC79988.1 - 4.3e-06 26.8 0.0 4.3e-06 26.8 0.0 2.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC79988.1 - 0.00018 21.1 6.3 1.2 8.6 1.0 3.3 3 0 0 3 3 3 3 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EMC79988.1 - 0.00023 21.1 6.4 0.0042 17.0 0.0 3.6 3 2 0 3 3 3 1 RsgA GTPase AAA_16 PF13191.6 EMC79988.1 - 0.00026 21.4 0.1 0.00096 19.6 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain Roc PF08477.13 EMC79988.1 - 0.00048 20.3 0.1 0.0017 18.5 0.0 2.0 2 0 0 2 2 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 EMC79988.1 - 0.00073 19.8 1.8 0.0013 19.0 0.0 2.3 2 1 0 2 2 2 1 AAA domain Ras PF00071.22 EMC79988.1 - 0.0065 16.1 0.7 0.019 14.6 0.0 2.2 2 0 0 2 2 2 1 Ras family AAA_7 PF12775.7 EMC79988.1 - 0.0068 15.9 0.0 0.019 14.5 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region ABC_tran PF00005.27 EMC79988.1 - 0.025 15.1 0.1 0.025 15.1 0.1 2.5 2 1 0 2 2 2 0 ABC transporter RNA_helicase PF00910.22 EMC79988.1 - 0.032 14.6 0.0 0.097 13.1 0.0 1.9 1 0 0 1 1 1 0 RNA helicase Microtub_bd PF16796.5 EMC79988.1 - 0.064 13.2 6.1 0.089 12.7 0.0 2.8 2 0 0 2 2 2 0 Microtubule binding Atg14 PF10186.9 EMC79988.1 - 0.089 11.9 13.1 0.22 10.6 13.1 1.7 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_23 PF13476.6 EMC79988.1 - 0.12 12.8 18.4 0.4 11.2 0.4 2.5 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EMC79988.1 - 0.16 11.7 0.1 0.46 10.3 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain IMD PF08397.11 EMC79988.1 - 0.2 11.0 13.1 0.39 10.1 13.1 1.4 1 0 0 1 1 1 0 IRSp53/MIM homology domain Fzo_mitofusin PF04799.13 EMC79988.1 - 0.54 9.8 9.3 0.39 10.3 7.3 1.8 2 0 0 2 2 2 0 fzo-like conserved region DUF87 PF01935.17 EMC79988.1 - 0.82 9.7 9.0 0.9 9.6 0.0 2.6 3 0 0 3 3 3 0 Helicase HerA, central domain Exonuc_VII_L PF02601.15 EMC79988.1 - 3.7 7.0 11.4 7.4 6.0 11.4 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit ATP_bind_1 PF03029.17 EMC79988.1 - 5 6.8 8.1 23 4.7 0.0 3.1 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein UcrQ PF02939.16 EMC79989.1 - 8.3e-35 118.6 0.1 9.1e-35 118.4 0.1 1.0 1 0 0 1 1 1 1 UcrQ family Cyt_b-c1_8 PF10890.8 EMC79989.1 - 0.00011 22.5 0.0 0.00012 22.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b-c1 complex subunit 8 LEAP-2 PF07359.11 EMC79990.1 - 4.7e-28 96.8 2.9 5.3e-28 96.7 2.9 1.0 1 0 0 1 1 1 1 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) DIM PF08194.12 EMC79990.1 - 0.058 13.6 0.6 0.097 12.9 0.6 1.4 1 0 0 1 1 1 0 DIM protein HSP70 PF00012.20 EMC79991.1 - 6.2e-210 698.4 17.1 9.7e-204 677.9 0.1 3.0 1 1 2 3 3 3 2 Hsp70 protein MreB_Mbl PF06723.13 EMC79991.1 - 1.2e-09 37.4 0.0 3.1e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 MreB/Mbl protein Raco_middle PF17651.1 EMC79991.1 - 0.027 14.2 0.1 2.6 7.7 0.1 2.6 2 0 0 2 2 2 0 RACo middle region Clr5 PF14420.6 EMC79991.1 - 0.058 13.6 0.1 0.058 13.6 0.1 3.1 4 0 0 4 4 4 0 Clr5 domain RSS_P20 PF11757.8 EMC79991.1 - 5.1 7.6 7.2 1.3 9.5 1.1 3.1 3 0 0 3 3 3 0 Suppressor of RNA silencing P21-like N-terminal domain RWD PF05773.22 EMC79992.1 - 1.4e-24 86.6 0.0 3.2e-24 85.4 0.0 1.7 1 0 0 1 1 1 1 RWD domain IBR PF01485.21 EMC79992.1 - 4.8e-17 61.9 19.0 1e-10 41.6 3.5 4.3 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_5 PF14634.6 EMC79992.1 - 0.00022 21.1 15.5 0.00022 21.1 15.5 3.6 3 0 0 3 3 3 2 zinc-RING finger domain zf-RING_2 PF13639.6 EMC79992.1 - 0.0035 17.6 12.4 0.0035 17.6 12.4 4.7 4 0 0 4 4 4 2 Ring finger domain zf-RING_UBOX PF13445.6 EMC79992.1 - 0.016 15.2 11.5 0.016 15.2 11.5 3.2 3 0 0 3 3 3 0 RING-type zinc-finger RWD PF05773.22 EMC79993.1 - 1.6e-24 86.4 0.0 3.2e-24 85.4 0.0 1.6 1 0 0 1 1 1 1 RWD domain IBR PF01485.21 EMC79993.1 - 1.1e-17 64.0 16.1 9.9e-11 41.7 3.5 4.3 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_5 PF14634.6 EMC79993.1 - 0.00021 21.2 15.5 0.00021 21.2 15.5 3.6 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.6 EMC79993.1 - 0.0033 17.7 12.4 0.0033 17.7 12.4 4.7 3 1 1 4 4 4 1 Ring finger domain zf-RING_UBOX PF13445.6 EMC79993.1 - 0.015 15.3 11.5 0.015 15.3 11.5 3.4 3 0 0 3 3 3 0 RING-type zinc-finger Glucosamine_iso PF01182.20 EMC79994.1 - 3.5e-16 59.8 0.0 5e-16 59.3 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase DUF2370 PF10176.9 EMC79995.1 - 1.3e-10 41.3 3.3 8.7e-08 32.1 0.1 2.6 1 1 1 3 3 3 2 Protein of unknown function (DUF2370) Comm PF15957.5 EMC79995.1 - 0.029 14.7 0.1 0.053 13.9 0.1 1.4 1 0 0 1 1 1 0 Commissureless Herpes_UL56 PF04534.12 EMC79995.1 - 0.092 12.2 0.8 0.13 11.7 0.8 1.2 1 0 0 1 1 1 0 Herpesvirus UL56 protein WBP-1 PF11669.8 EMC79995.1 - 0.41 11.3 0.1 0.41 11.3 0.1 2.8 3 1 1 4 4 4 0 WW domain-binding protein 1 Sprouty PF05210.13 EMC79996.1 - 5.1e-27 94.3 31.4 1e-26 93.3 31.4 1.5 1 0 0 1 1 1 1 Sprouty protein (Spry) FGF PF00167.18 EMC79997.1 - 3.5e-41 140.2 0.0 4.1e-41 140.0 0.0 1.1 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.13 EMC79997.1 - 0.0015 18.7 0.0 0.0023 18.1 0.0 1.3 1 0 0 1 1 1 1 Fascin domain MMS1_N PF10433.9 EMC79997.1 - 0.18 10.4 0.0 0.21 10.2 0.0 1.1 1 0 0 1 1 1 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term GCR PF02155.15 EMC79999.1 - 1.5e-179 596.9 1.8 1.8e-179 596.6 1.8 1.1 1 0 0 1 1 1 1 Glucocorticoid receptor Hormone_recep PF00104.30 EMC79999.1 - 1.2e-29 103.3 5.2 1.2e-29 103.3 5.2 1.5 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 EMC79999.1 - 3e-28 98.1 13.0 5.5e-28 97.2 13.0 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Collagen PF01391.18 EMC80000.1 - 0.0034 17.1 10.4 1.3 8.8 1.7 3.8 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) DUF4021 PF13213.6 EMC80000.1 - 0.11 12.5 0.9 95 3.1 0.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4021) Yip1 PF04893.17 EMC80001.1 - 2.7e-10 40.3 15.8 3.7e-10 39.8 15.8 1.3 1 0 0 1 1 1 1 Yip1 domain BTB_2 PF02214.22 EMC80002.1 - 7.8e-16 58.2 0.0 1.7e-15 57.1 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 EMC80002.1 - 0.0053 16.8 0.0 0.012 15.7 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Dynein_C PF18199.1 EMC80002.1 - 0.02 14.1 0.0 0.028 13.7 0.0 1.1 1 0 0 1 1 1 0 Dynein heavy chain C-terminal domain DnaJ_CXXCXGXG PF00684.19 EMC80004.1 - 0.013 15.8 12.3 0.06 13.7 12.3 2.1 1 1 0 1 1 1 0 DnaJ central domain Anti-TRAP PF15777.5 EMC80004.1 - 0.63 10.1 9.1 16 5.6 9.1 2.5 1 1 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein SH3_1 PF00018.28 EMC80005.1 - 4.3e-21 74.3 0.0 4.8e-11 42.1 0.0 2.3 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 EMC80005.1 - 1.9e-18 66.0 0.0 5.9e-10 38.8 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 EMC80005.1 - 3e-18 65.3 0.0 6.5e-12 45.0 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain zf-C3HC4_2 PF13923.6 EMC80005.1 - 5.6e-10 38.9 10.4 1.2e-09 37.9 10.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC80005.1 - 6.5e-10 38.7 9.5 1.2e-09 37.8 9.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC80005.1 - 3.5e-09 36.5 8.6 8e-09 35.4 8.6 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EMC80005.1 - 7e-09 35.9 8.8 7e-09 35.9 8.8 1.7 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EMC80005.1 - 1.5e-08 34.3 6.6 3.1e-08 33.3 6.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC80005.1 - 7.5e-08 32.2 8.9 7.5e-08 32.2 8.9 1.6 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_4 PF14570.6 EMC80005.1 - 4.7e-06 26.3 7.4 1e-05 25.2 7.4 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 EMC80005.1 - 0.00013 22.0 9.3 0.00026 21.1 9.3 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EMC80005.1 - 0.00083 19.2 9.3 0.0067 16.3 9.8 2.0 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EMC80005.1 - 0.028 14.7 6.3 0.058 13.7 6.3 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EMC80005.1 - 0.032 14.0 2.4 0.032 14.0 2.4 2.5 1 1 1 2 2 2 0 RING-like zinc finger DUF1272 PF06906.11 EMC80005.1 - 0.94 9.6 7.8 0.28 11.3 3.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) DZR PF12773.7 EMC80005.1 - 1.5 8.9 10.1 2.9 8.0 8.7 2.1 2 0 0 2 2 2 0 Double zinc ribbon zf-MIZ PF02891.20 EMC80005.1 - 1.5 8.6 7.3 3.1 7.6 7.3 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-ANAPC11 PF12861.7 EMC80005.1 - 1.8 8.7 5.3 3.6 7.7 5.3 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zinc-ribbons_6 PF07191.12 EMC80005.1 - 1.8 8.6 8.8 3.8 7.6 8.8 1.5 1 0 0 1 1 1 0 zinc-ribbons zf-Nse PF11789.8 EMC80005.1 - 3.3 7.6 8.6 1.7 8.5 6.4 1.7 2 0 0 2 2 1 0 Zinc-finger of the MIZ type in Nse subunit tRNA-synt_1 PF00133.22 EMC80006.1 - 2.8e-39 134.9 0.0 2.2e-24 85.7 0.0 2.6 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EMC80006.1 - 2.9e-18 65.8 0.0 3.5e-09 35.9 0.0 2.6 3 0 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EMC80006.1 - 2.3e-16 60.1 0.0 5.9e-16 58.8 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EMC80006.1 - 2e-06 27.4 0.0 4e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EMC80006.1 - 0.031 13.2 0.0 0.067 12.1 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (K) FF PF01846.19 EMC80007.1 - 8.7e-75 246.7 45.2 1.8e-14 53.7 1.4 6.6 6 0 0 6 6 6 6 FF domain WW PF00397.26 EMC80007.1 - 8.2e-21 73.8 20.5 9.5e-08 32.0 5.1 3.9 3 0 0 3 3 3 3 WW domain Glyco_hyd_101C PF17451.2 EMC80007.1 - 8e-05 22.9 4.0 1.4 9.2 1.2 4.0 3 0 0 3 3 3 3 Glycosyl hydrolase 101 beta sandwich domain RhoGAP-FF1 PF16512.5 EMC80007.1 - 0.0012 19.5 1.8 0.0012 19.5 1.8 4.9 2 2 3 5 5 5 2 p190-A and -B Rho GAPs FF domain Pkinase PF00069.25 EMC80008.1 - 2.5e-64 217.2 0.1 3.6e-64 216.7 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC80008.1 - 1e-37 129.8 0.2 1.4e-37 129.4 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC80008.1 - 1.5e-13 50.7 0.1 2e-13 50.3 0.1 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EMC80008.1 - 0.002 18.1 0.1 0.0032 17.4 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EMC80008.1 - 0.0023 16.8 0.0 0.0046 15.8 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EMC80008.1 - 0.0027 16.7 0.4 0.005 15.8 0.4 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 EMC80008.1 - 0.033 13.3 0.1 0.074 12.1 0.1 1.5 1 0 0 1 1 1 0 Seadornavirus VP7 Endonuclease_5 PF04493.14 EMC80008.1 - 0.12 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Endonuclease V Amidohydro_1 PF01979.20 EMC80009.1 - 3e-38 132.0 0.0 4e-38 131.6 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EMC80009.1 - 1.4e-12 47.8 0.4 3.2e-07 30.2 0.0 2.6 3 0 0 3 3 3 2 Amidohydrolase family Amidohydro_2 PF04909.14 EMC80009.1 - 0.00017 21.5 0.0 0.0005 19.9 0.0 1.8 2 0 0 2 2 2 1 Amidohydrolase DUF3928 PF13065.6 EMC80009.1 - 0.053 14.3 0.0 0.11 13.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3928) PX PF00787.24 EMC80010.1 - 0.077 13.0 0.4 0.12 12.4 0.4 1.2 1 0 0 1 1 1 0 PX domain TB2_DP1_HVA22 PF03134.19 EMC80012.1 - 7.3e-22 77.1 10.0 1e-21 76.6 10.0 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family JmjC PF02373.22 EMC80013.1 - 7.7e-16 58.6 0.0 1.9e-15 57.3 0.0 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 EMC80013.1 - 0.095 12.4 0.1 0.46 10.2 0.0 2.1 2 0 0 2 2 2 0 Cupin domain C1_2 PF03107.16 EMC80013.1 - 0.13 12.6 4.9 0.43 10.9 4.9 1.9 1 0 0 1 1 1 0 C1 domain zf-C5HC2 PF02928.16 EMC80013.1 - 0.14 12.5 3.4 0.48 10.9 3.4 1.9 1 0 0 1 1 1 0 C5HC2 zinc finger 2-Hacid_dh_C PF02826.19 EMC80014.1 - 8.9e-57 191.3 0.0 1.2e-56 190.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EMC80014.1 - 4.7e-27 94.3 0.0 5.6e-27 94.0 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EMC80014.1 - 8.4e-05 22.8 0.0 0.00017 21.8 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase XdhC_C PF13478.6 EMC80014.1 - 0.083 13.4 0.0 0.27 11.7 0.0 1.9 2 0 0 2 2 2 0 XdhC Rossmann domain F420_oxidored PF03807.17 EMC80014.1 - 0.11 13.1 0.0 0.89 10.2 0.0 2.3 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent GDNF PF02351.16 EMC80015.1 - 9.3e-40 135.5 43.8 1.4e-22 80.4 8.2 3.1 3 0 0 3 3 3 3 GDNF/GAS1 domain Dcc1 PF09724.9 EMC80015.1 - 0.081 12.2 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Sister chromatid cohesion protein Dcc1 TPR_1 PF00515.28 EMC80016.1 - 5.2e-26 89.4 36.6 6.7e-06 25.7 0.1 10.2 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_2 PF07719.17 EMC80016.1 - 1.5e-24 84.1 36.8 0.00049 20.0 0.1 10.5 10 0 0 10 10 10 8 Tetratricopeptide repeat ANAPC8 PF04049.13 EMC80016.1 - 1.5e-23 83.4 2.5 1.5e-23 83.4 2.5 2.7 2 1 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_8 PF13181.6 EMC80016.1 - 7.3e-19 66.4 29.8 7.9e-05 22.6 0.0 10.5 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_14 PF13428.6 EMC80016.1 - 2.1e-14 53.0 19.1 0.0045 17.7 0.0 9.1 8 1 1 9 9 9 3 Tetratricopeptide repeat TPR_19 PF14559.6 EMC80016.1 - 3.3e-11 43.5 21.8 0.017 15.6 0.5 7.9 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 EMC80016.1 - 3.9e-09 37.0 12.7 0.0013 19.4 0.0 7.7 6 2 1 8 8 8 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMC80016.1 - 1e-08 34.7 22.1 1.8e-06 27.5 0.2 5.9 5 1 1 6 6 6 3 TPR repeat TPR_7 PF13176.6 EMC80016.1 - 3.9e-08 32.8 21.5 0.091 12.8 0.2 8.7 9 0 0 9 9 9 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC80016.1 - 1.1e-06 28.8 36.7 0.00054 20.1 1.1 6.3 4 1 1 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EMC80016.1 - 2.4e-06 27.5 15.9 0.094 13.1 0.0 6.8 9 0 0 9 9 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 EMC80016.1 - 1.1e-05 25.6 27.0 0.26 11.6 0.1 8.7 6 2 2 9 9 9 3 Tetratricopeptide repeat TPR_6 PF13174.6 EMC80016.1 - 3.9e-05 24.0 30.5 1.6 9.5 0.0 9.6 11 0 0 11 11 10 2 Tetratricopeptide repeat TPR_10 PF13374.6 EMC80016.1 - 0.002 17.9 12.1 11 6.1 0.0 7.0 7 0 0 7 7 7 0 Tetratricopeptide repeat DUF772 PF05598.11 EMC80016.1 - 0.0031 17.5 0.1 0.0085 16.1 0.1 1.8 1 0 0 1 1 1 1 Transposase domain (DUF772) TPR_9 PF13371.6 EMC80016.1 - 0.019 15.1 0.2 0.019 15.1 0.2 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat PPR PF01535.20 EMC80016.1 - 0.11 12.8 0.1 16 6.0 0.0 4.1 4 0 0 4 4 4 0 PPR repeat JAKMIP_CC3 PF16034.5 EMC80017.1 - 5.5e-85 284.4 19.4 5.5e-85 284.4 19.4 6.7 3 2 1 6 6 6 1 JAKMIP CC3 domain Pox_A_type_inc PF04508.12 EMC80017.1 - 0.018 14.8 0.0 0.018 14.8 0.0 7.8 10 0 0 10 10 10 0 Viral A-type inclusion protein repeat Anth_Ig PF05587.13 EMC80018.1 - 3.4e-43 146.1 0.4 6.6e-43 145.2 0.4 1.5 1 0 0 1 1 1 1 Anthrax receptor extracellular domain Ant_C PF05586.11 EMC80018.1 - 5.2e-42 142.4 1.0 8.3e-42 141.7 1.0 1.3 1 0 0 1 1 1 1 Anthrax receptor C-terminus region VWA PF00092.28 EMC80018.1 - 1.8e-24 86.9 0.0 2.5e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EMC80018.1 - 3.3e-10 40.6 0.0 9.8e-10 39.0 0.0 1.8 3 0 0 3 3 3 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 EMC80018.1 - 2.7e-05 23.7 0.0 4.5e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein Sox_N PF12444.8 EMC80019.1 - 0.0015 19.6 0.1 39 5.5 0.1 5.0 5 1 1 6 6 6 2 Sox developmental protein N terminal Mito_carr PF00153.27 EMC80020.1 - 3.7e-65 215.9 0.5 5.4e-22 77.5 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF4042 PF13251.6 EMC80020.1 - 0.066 12.9 0.0 0.39 10.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4042) zf-HC5HC2H PF13771.6 EMC80021.1 - 1.5e-14 54.0 3.8 1.5e-14 54.0 3.8 4.0 4 1 0 4 4 4 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EMC80021.1 - 2.1e-07 31.1 9.4 2.1e-07 31.1 9.4 3.3 2 1 2 4 4 4 1 PHD-zinc-finger like domain zf-RING_2 PF13639.6 EMC80021.1 - 5.9e-07 29.7 5.6 5.9e-07 29.7 5.6 4.8 4 2 0 4 4 4 1 Ring finger domain zf-RING_11 PF17123.5 EMC80021.1 - 0.0045 16.7 2.6 0.0045 16.7 2.6 4.3 4 2 0 4 4 4 1 RING-like zinc finger PhnA_Zn_Ribbon PF08274.12 EMC80021.1 - 0.28 11.2 0.2 0.28 11.2 0.2 5.3 7 0 0 7 7 7 0 PhnA Zinc-Ribbon zf-RanBP PF00641.18 EMC80021.1 - 1.2 8.5 0.0 1.2 8.5 0.0 4.7 5 0 0 5 5 5 0 Zn-finger in Ran binding protein and others SPRY PF00622.28 EMC80022.1 - 2.8e-19 69.4 0.0 4.4e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 SPRY domain SOCS_box PF07525.16 EMC80022.1 - 1.4e-10 41.4 2.9 2.7e-10 40.4 2.9 1.5 1 0 0 1 1 1 1 SOCS box HELP PF03451.14 EMC80022.1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 HELP motif zf-B_box PF00643.24 EMC80023.1 - 8.5e-09 35.4 3.6 8.5e-09 35.4 3.6 6.1 6 1 0 6 6 6 2 B-box zinc finger fn3 PF00041.21 EMC80023.1 - 3.7e-08 33.6 0.0 6.5e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 EMC80023.1 - 0.0098 16.4 0.0 0.02 15.4 0.0 1.5 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Nitrate_red_del PF02613.15 EMC80023.1 - 0.56 10.2 2.4 2.8 7.9 0.8 2.3 1 1 1 2 2 2 0 Nitrate reductase delta subunit Cadherin PF00028.17 EMC80024.1 - 1e-15 57.9 0.2 5.6e-10 39.5 0.6 2.6 2 0 0 2 2 2 2 Cadherin domain Laminin_G_3 PF13385.6 EMC80024.1 - 0.00037 20.7 0.0 0.00066 19.9 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily TMEM132D_C PF15706.5 EMC80024.1 - 0.0013 18.5 0.0 0.0031 17.2 0.0 1.7 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term V_ATPase_I PF01496.19 EMC80024.1 - 0.0049 14.9 1.0 0.0073 14.3 1.0 1.2 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Chordopox_A13L PF05961.11 EMC80024.1 - 0.046 14.0 0.0 0.14 12.4 0.0 1.8 1 0 0 1 1 1 0 Chordopoxvirus A13L protein LRR19-TM PF15176.6 EMC80024.1 - 0.059 13.4 1.3 0.16 12.0 1.3 1.7 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain Asparaginase_2 PF01112.18 EMC80025.1 - 3.5e-83 279.2 0.8 4.5e-83 278.8 0.8 1.0 1 0 0 1 1 1 1 Asparaginase zf-GRF PF06839.12 EMC80026.1 - 1.1e-35 121.4 24.6 3.8e-19 68.5 5.4 3.9 4 0 0 4 4 4 2 GRF zinc finger H2TH PF06831.14 EMC80026.1 - 2.4e-11 43.5 0.0 4.9e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Fapy_DNA_glyco PF01149.24 EMC80026.1 - 7e-05 23.4 0.0 0.00017 22.2 0.0 1.6 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain zf-RanBP PF00641.18 EMC80026.1 - 0.00069 18.9 2.6 0.00069 18.9 2.6 2.8 2 1 1 3 3 3 1 Zn-finger in Ran binding protein and others DUF687 PF05095.12 EMC80026.1 - 0.11 10.9 0.1 0.17 10.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF687) DZR PF12773.7 EMC80026.1 - 4.1 7.5 15.7 0.94 9.6 1.8 3.2 1 1 1 2 2 2 0 Double zinc ribbon PDGF PF00341.17 EMC80027.1 - 7.2e-24 83.9 6.8 7.2e-24 83.9 6.8 3.2 3 0 0 3 3 3 1 PDGF/VEGF domain CXCXC PF03128.14 EMC80027.1 - 9e-09 35.2 62.0 0.00052 20.3 5.0 9.0 8 0 0 8 8 8 6 CXCXC repeat SPC22 PF04573.12 EMC80028.1 - 3e-41 140.8 0.0 3.9e-41 140.4 0.0 1.2 1 0 0 1 1 1 1 Signal peptidase subunit AsmA_2 PF13502.6 EMC80028.1 - 0.013 15.1 0.1 0.017 14.7 0.1 1.1 1 0 0 1 1 1 0 AsmA-like C-terminal region Ank_2 PF12796.7 EMC80029.1 - 9.8e-49 163.9 7.5 1.2e-14 54.6 0.2 3.6 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC80029.1 - 4.3e-31 106.9 2.1 8.9e-11 42.1 0.1 5.2 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC80029.1 - 1.8e-28 95.4 1.9 3.3e-05 23.9 0.1 7.0 7 0 0 7 7 7 6 Ankyrin repeat Ank PF00023.30 EMC80029.1 - 6.3e-27 92.8 9.0 2.6e-06 27.6 0.2 6.7 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.6 EMC80029.1 - 3.5e-22 78.2 4.5 1.4e-06 28.5 0.1 6.0 1 1 5 6 6 6 4 Ankyrin repeats (many copies) SOCS_box PF07525.16 EMC80029.1 - 1.9e-10 40.9 8.7 3.4e-10 40.1 7.7 1.9 2 0 0 2 2 2 1 SOCS box WD40 PF00400.32 EMC80030.1 - 8.9e-32 108.6 38.6 5.8e-07 30.1 0.2 10.5 12 0 0 12 12 12 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC80030.1 - 9.9e-23 80.3 0.3 0.00018 21.7 0.0 6.2 3 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMC80030.1 - 0.00054 18.7 7.8 0.22 10.1 0.0 5.6 6 1 1 7 7 7 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EMC80030.1 - 0.07 12.1 0.3 4.1 6.3 0.0 3.0 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein TAF6_C PF07571.13 EMC80031.1 - 6.3e-08 32.8 0.0 1.2e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain DUF3039 PF11238.8 EMC80031.1 - 0.11 12.3 0.3 0.22 11.3 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3039) RNase_PH PF01138.21 EMC80032.1 - 1.5e-36 125.8 0.4 2.9e-22 79.6 0.0 2.9 3 0 0 3 3 3 2 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EMC80032.1 - 1.7e-15 56.8 0.9 4.5e-10 39.4 0.0 2.7 2 0 0 2 2 2 2 3' exoribonuclease family, domain 2 PNPase PF03726.14 EMC80032.1 - 1.3e-09 38.4 0.2 3.5e-09 37.0 0.2 1.8 1 0 0 1 1 1 1 Polyribonucleotide nucleotidyltransferase, RNA binding domain S1 PF00575.23 EMC80032.1 - 2.1e-06 28.0 0.0 1.1e-05 25.6 0.0 2.3 3 0 0 3 3 3 1 S1 RNA binding domain KH_1 PF00013.29 EMC80032.1 - 0.0002 21.1 0.0 0.0029 17.4 0.0 2.6 2 0 0 2 2 2 1 KH domain OAF PF14941.6 EMC80032.1 - 0.041 13.3 0.2 0.084 12.3 0.2 1.4 1 0 0 1 1 1 0 Transcriptional regulator, Out at first ProQ_C PF17516.2 EMC80032.1 - 0.043 13.3 0.0 3 7.3 0.0 3.0 2 1 0 2 2 2 0 ProQ C-terminal domain ARL2_Bind_BART PF11527.8 EMC80033.1 - 2.7e-25 88.7 4.2 2.7e-25 88.7 4.2 1.5 2 0 0 2 2 2 1 The ARF-like 2 binding protein BART Reticulon PF02453.17 EMC80033.1 - 0.14 12.2 0.1 0.21 11.5 0.1 1.2 1 0 0 1 1 1 0 Reticulon HOOK PF05622.12 EMC80034.1 - 9.3e-35 119.9 65.7 9.3e-35 119.9 65.7 5.8 1 1 5 6 6 6 2 HOOK protein APG6_N PF17675.1 EMC80034.1 - 0.00044 20.8 10.1 0.00044 20.8 10.1 15.0 2 1 11 14 14 14 4 Apg6 coiled-coil region GAS PF13851.6 EMC80034.1 - 0.0032 16.8 30.1 0.0032 16.8 30.1 12.4 1 1 10 12 12 12 6 Growth-arrest specific micro-tubule binding DUF4472 PF14739.6 EMC80034.1 - 0.005 17.6 17.3 0.005 17.6 17.3 15.1 4 3 11 16 16 16 3 Domain of unknown function (DUF4472) tRNA_edit PF04073.15 EMC80035.1 - 6.4e-26 90.8 0.0 7.8e-26 90.6 0.0 1.1 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain HTH_10 PF04967.12 EMC80035.1 - 0.091 12.6 0.0 0.49 10.2 0.0 2.0 2 0 0 2 2 2 0 HTH DNA binding domain GTP_EFTU PF00009.27 EMC80036.1 - 3.2e-34 118.2 3.4 1.6e-32 112.7 3.4 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EMC80036.1 - 6.7e-32 109.8 1.4 3.1e-31 107.6 1.4 2.2 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 EMC80036.1 - 9.7e-10 38.5 0.4 3.3e-09 36.8 0.1 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase Arf PF00025.21 EMC80036.1 - 7.7e-05 22.2 0.2 0.00032 20.2 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family Ras PF00071.22 EMC80036.1 - 0.00035 20.2 0.1 0.0017 18.0 0.0 2.3 2 0 0 2 2 2 1 Ras family SRPRB PF09439.10 EMC80036.1 - 0.00069 19.1 1.1 0.0081 15.6 0.3 2.8 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EMC80036.1 - 0.00089 18.8 0.1 0.0031 17.1 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B Roc PF08477.13 EMC80036.1 - 0.0021 18.3 0.0 0.0058 16.8 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase IF2_N PF04760.15 EMC80036.1 - 0.0043 16.9 1.0 0.078 12.8 0.1 2.6 2 0 0 2 2 2 1 Translation initiation factor IF-2, N-terminal region Dynamin_N PF00350.23 EMC80036.1 - 0.011 15.9 0.9 2.9 7.9 0.0 3.4 2 1 1 3 3 3 0 Dynamin family GTP_EFTU_D4 PF14578.6 EMC80036.1 - 0.018 15.0 1.2 0.12 12.3 0.2 2.5 2 0 0 2 2 2 0 Elongation factor Tu domain 4 AAA_26 PF13500.6 EMC80036.1 - 0.03 14.1 0.5 0.11 12.4 0.1 2.1 2 0 0 2 2 2 0 AAA domain MHB PF16525.5 EMC80036.1 - 0.16 12.2 0.1 0.39 11.0 0.1 1.6 1 0 0 1 1 1 0 Haemophore, haem-binding Myco_arth_vir_N PF09610.10 EMC80036.1 - 1.4 9.0 4.5 4.1 7.6 4.5 1.8 1 0 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) AAA_23 PF13476.6 EMC80036.1 - 3.2 8.2 10.7 5.8 7.4 0.0 3.2 3 1 0 3 3 3 0 AAA domain ubiquitin PF00240.23 EMC80037.1 - 6.4e-34 115.5 0.5 1.1e-33 114.8 0.2 1.5 2 0 0 2 2 2 1 Ubiquitin family Ribosomal_S27 PF01599.19 EMC80037.1 - 2.9e-28 97.8 4.1 5.8e-28 96.8 4.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S27a Rad60-SLD PF11976.8 EMC80037.1 - 4.4e-16 58.5 0.3 8.8e-16 57.5 0.3 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EMC80037.1 - 4e-06 27.2 0.4 2e-05 25.0 0.1 2.2 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EMC80037.1 - 0.00016 21.7 0.7 0.00034 20.7 0.7 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 EMC80037.1 - 0.0046 16.9 0.1 0.0068 16.3 0.1 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 EMC80037.1 - 0.0065 17.0 0.5 0.009 16.6 0.5 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Ubiquitin_5 PF18037.1 EMC80037.1 - 0.0073 16.6 0.7 0.014 15.8 0.0 1.8 1 1 1 2 2 2 1 Ubiquitin-like domain IBR PF01485.21 EMC80037.1 - 0.039 14.2 4.2 0.064 13.5 4.2 1.4 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain Ubiquitin_4 PF18036.1 EMC80037.1 - 0.1 12.7 2.2 9.7 6.3 0.0 2.5 3 0 0 3 3 3 0 Ubiquitin-like domain WD40 PF00400.32 EMC80038.1 - 2.2e-66 218.1 83.8 0.00013 22.7 0.1 28.4 31 0 0 31 31 31 14 WD domain, G-beta repeat HELP PF03451.14 EMC80038.1 - 6.9e-57 189.2 2.5 4.1e-20 71.4 0.1 3.4 3 0 0 3 3 3 3 HELP motif ANAPC4_WD40 PF12894.7 EMC80038.1 - 4e-38 129.6 12.7 1e-07 32.1 0.0 13.3 9 4 4 13 13 13 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMC80038.1 - 8.6e-12 44.7 3.0 0.015 14.3 0.0 7.8 6 3 3 9 9 9 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 EMC80038.1 - 2.9e-07 29.4 9.1 0.22 10.0 0.0 6.6 6 1 1 7 7 7 3 Cytochrome D1 heme domain WD40_like PF17005.5 EMC80038.1 - 8.3e-07 28.6 2.0 1.4 8.2 0.0 7.4 8 1 0 8 8 8 2 WD40-like domain Frtz PF11768.8 EMC80038.1 - 4.8e-06 25.2 0.0 0.0036 15.7 0.0 4.1 3 1 1 4 4 4 1 WD repeat-containing and planar cell polarity effector protein Fritz PD40 PF07676.12 EMC80038.1 - 2.7e-05 24.0 0.3 49 4.0 0.0 6.9 8 0 0 8 8 8 0 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 EMC80038.1 - 0.00013 20.9 0.0 0.22 10.2 0.0 4.0 4 0 0 4 4 4 1 Nup133 N terminal like Nbas_N PF15492.6 EMC80038.1 - 0.041 13.2 0.1 13 5.0 0.0 4.4 5 1 1 6 6 6 0 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 EMC80038.1 - 0.073 11.7 1.0 39 2.7 0.1 4.0 4 1 1 5 5 5 0 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 EMC80038.1 - 0.1 11.5 0.2 27 3.5 0.0 3.8 4 0 0 4 4 4 0 Partner and localizer of BRCA2 WD40 domain PSII_BNR PF14870.6 EMC80038.1 - 0.15 11.3 2.2 4.9 6.3 0.0 3.3 4 0 0 4 4 4 0 Photosynthesis system II assembly factor YCF48 UL11 PF11094.8 EMC80038.1 - 0.25 11.3 0.7 2.3 8.2 0.0 3.0 4 0 0 4 4 4 0 Membrane-associated tegument protein Acylphosphatase PF00708.18 EMC80039.1 - 1.1e-15 57.8 0.4 5e-15 55.7 0.4 1.8 1 1 0 1 1 1 1 Acylphosphatase PRKCSH PF07915.13 EMC80041.1 - 1.2e-41 141.6 15.9 2.6e-24 86.0 6.6 2.4 2 0 0 2 2 2 2 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 EMC80041.1 - 3.5e-11 43.0 1.8 0.00018 21.3 0.1 2.5 2 0 0 2 2 2 2 Glucosidase II beta subunit-like protein Ank_2 PF12796.7 EMC80042.1 - 1.9e-44 150.2 0.2 2.2e-18 66.6 0.4 4.7 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC80042.1 - 7.8e-38 128.4 4.1 1.4e-11 44.7 0.1 6.9 4 2 3 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC80042.1 - 7.7e-32 105.8 1.9 0.00014 22.0 0.0 8.3 7 0 0 7 7 7 7 Ankyrin repeat Ank PF00023.30 EMC80042.1 - 1.7e-31 107.3 3.9 1.1e-05 25.6 0.0 8.5 6 2 2 8 8 8 7 Ankyrin repeat Ank_5 PF13857.6 EMC80042.1 - 1.1e-28 98.9 1.5 2.3e-05 24.6 0.0 8.4 4 2 5 9 9 9 6 Ankyrin repeats (many copies) SOCS_box PF07525.16 EMC80042.1 - 1.5e-09 38.1 6.8 3.1e-09 37.0 6.8 1.5 1 0 0 1 1 1 1 SOCS box MARVEL PF01284.23 EMC80043.1 - 4.2e-11 43.1 10.3 4.9e-11 42.8 10.3 1.1 1 0 0 1 1 1 1 Membrane-associating domain SH3_1 PF00018.28 EMC80045.1 - 1.5e-13 50.1 0.1 4.9e-13 48.5 0.0 2.0 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EMC80045.1 - 3.7e-11 42.5 0.0 8.3e-11 41.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EMC80045.1 - 8.2e-10 38.4 0.0 2.7e-09 36.7 0.0 2.0 1 0 0 1 1 1 1 Variant SH3 domain TRAP_alpha PF03896.16 EMC80045.1 - 0.33 10.1 11.2 0.11 11.6 6.8 1.9 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit BUD22 PF09073.10 EMC80045.1 - 0.94 8.7 16.3 1.4 8.2 16.3 1.2 1 0 0 1 1 1 0 BUD22 PTPRCAP PF15713.5 EMC80045.1 - 2.3 8.5 17.4 1.1 9.6 10.0 2.3 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Trypan_PARP PF05887.11 EMC80045.1 - 2.8 7.9 16.3 0.024 14.6 8.5 1.6 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Nop25 PF09805.9 EMC80045.1 - 6.2 7.3 15.6 2.6 8.5 10.1 2.1 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) Mad3_BUB1_I PF08311.12 EMC80046.1 - 1e-33 116.0 0.0 2e-33 115.0 0.0 1.5 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Pkinase PF00069.25 EMC80046.1 - 8e-16 58.2 0.0 1.3e-15 57.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC80046.1 - 1e-07 31.5 0.0 1.7e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Mad3_BUB1_I_2 PF17014.5 EMC80046.1 - 0.0088 16.2 0.0 0.022 14.9 0.0 1.6 1 0 0 1 1 1 1 Putative Mad3/BUB1 like region 1 protein Pkinase_fungal PF17667.1 EMC80046.1 - 0.16 10.8 0.0 0.34 9.6 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Pkinase_Tyr PF07714.17 EMC80047.1 - 2.8e-92 308.6 0.0 3.8e-92 308.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC80047.1 - 2.4e-38 132.0 0.0 3.4e-38 131.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 EMC80047.1 - 1.2e-15 57.7 0.1 1.4e-07 31.7 0.1 2.5 2 0 0 2 2 2 2 Fibronectin type III domain Ig_2 PF13895.6 EMC80047.1 - 5e-15 55.6 0.1 3.3e-07 30.5 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 EMC80047.1 - 7.3e-14 52.1 1.5 1.9e-07 31.6 0.1 2.9 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 EMC80047.1 - 1.4e-10 41.1 0.0 0.00081 19.4 0.0 2.9 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 EMC80047.1 - 2.8e-10 40.2 0.1 0.00011 22.3 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 EMC80047.1 - 0.0068 16.6 0.4 11 6.2 0.0 3.6 4 0 0 4 4 4 1 Immunoglobulin V-set domain APH PF01636.23 EMC80047.1 - 0.056 13.4 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EMC80047.1 - 0.084 12.2 0.0 0.23 10.7 0.0 1.7 2 0 0 2 2 2 0 Kinase-like C2-set_2 PF08205.12 EMC80047.1 - 0.095 12.8 0.1 9.3 6.4 0.0 3.0 2 1 0 2 2 2 0 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 EMC80047.1 - 0.11 12.8 0.0 4.1 7.8 0.1 2.6 2 0 0 2 2 2 0 Immunoglobulin C1-set domain cEGF PF12662.7 EMC80048.1 - 4.4e-16 58.5 24.9 9.9e-13 47.8 1.9 4.8 5 0 0 5 5 5 3 Complement Clr-like EGF-like EGF_CA PF07645.15 EMC80048.1 - 8.1e-15 54.8 14.8 1.9e-09 37.5 5.5 5.2 5 1 0 5 5 5 2 Calcium-binding EGF domain Sushi PF00084.20 EMC80048.1 - 2.3e-13 50.5 11.1 3.7e-11 43.4 0.8 3.8 3 0 0 3 3 3 2 Sushi repeat (SCR repeat) FXa_inhibition PF14670.6 EMC80048.1 - 1.4e-10 41.3 3.8 1.4e-10 41.3 3.8 5.1 5 0 0 5 5 5 2 Coagulation Factor Xa inhibitory site EGF PF00008.27 EMC80048.1 - 1.2e-05 25.5 1.7 1.2e-05 25.5 1.7 6.1 7 0 0 7 7 7 2 EGF-like domain EGF_3 PF12947.7 EMC80048.1 - 0.00038 20.6 24.8 0.0037 17.4 3.1 5.3 4 1 1 5 5 5 2 EGF domain hEGF PF12661.7 EMC80048.1 - 0.0022 18.6 3.7 0.0022 18.6 3.7 6.2 8 0 0 8 8 8 3 Human growth factor-like EGF RANK_CRD_2 PF18278.1 EMC80048.1 - 0.096 12.8 7.5 3.3 7.9 0.9 3.1 2 0 0 2 2 2 0 Receptor activator of the NF-KB cysteine-rich repeat domain 2 zf_CCCH_4 PF18345.1 EMC80049.1 - 2e-14 53.1 29.4 1.5e-07 31.2 2.8 3.7 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH_4 PF18044.1 EMC80049.1 - 4.5e-13 48.7 20.8 0.0002 21.1 4.9 3.7 3 0 0 3 3 3 3 CCCH-type zinc finger zf-CCCH PF00642.24 EMC80049.1 - 7.7e-10 38.4 24.8 3.5e-05 23.6 1.7 3.4 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 EMC80049.1 - 5e-07 30.0 21.9 0.018 15.5 1.3 3.9 3 0 0 3 3 3 3 RNA-binding, Nab2-type zinc finger Torus PF16131.5 EMC80049.1 - 0.00077 20.1 11.8 0.0044 17.7 1.5 5.0 3 1 2 5 5 5 2 Torus domain zf-CCCH_3 PF15663.5 EMC80049.1 - 0.014 15.6 18.1 0.74 10.1 3.1 3.3 1 1 1 2 2 2 0 Zinc-finger containing family Paramecium_SA PF01508.16 EMC80049.1 - 0.36 11.3 3.4 0.83 10.1 3.4 1.5 1 0 0 1 1 1 0 Paramecium surface antigen domain SNAP PF14938.6 EMC80050.1 - 4.3e-111 370.8 22.2 5e-111 370.7 22.2 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 EMC80050.1 - 5.6e-07 29.8 18.6 0.00066 19.9 0.3 4.2 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMC80050.1 - 0.00048 20.0 11.1 0.067 13.3 0.0 5.5 5 2 2 7 7 7 2 Tetratricopeptide repeat Spatacsin_C PF14649.6 EMC80050.1 - 0.0016 17.6 13.1 0.015 14.4 2.8 2.6 1 1 2 3 3 3 2 Spatacsin C-terminus TPR_6 PF13174.6 EMC80050.1 - 0.0019 18.7 13.6 2.6 8.9 0.3 6.1 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMC80050.1 - 0.0045 17.7 7.3 17 6.6 0.0 5.8 6 1 0 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.6 EMC80050.1 - 0.051 14.2 10.0 0.15 12.7 0.3 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 EMC80050.1 - 0.14 12.4 22.2 3 8.3 0.7 6.5 6 2 1 7 7 6 0 Tetratricopeptide repeat PhageMin_Tail PF10145.9 EMC80050.1 - 0.14 12.0 2.1 3.1 7.6 0.1 2.4 1 1 1 2 2 2 0 Phage-related minor tail protein DUF2150 PF09920.9 EMC80050.1 - 0.22 11.5 4.7 0.089 12.8 0.9 2.2 2 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2150) NSF PF02071.20 EMC80050.1 - 0.23 12.3 39.5 0.61 11.1 2.7 8.8 8 1 1 9 9 9 0 Aromatic-di-Alanine (AdAR) repeat TPR_2 PF07719.17 EMC80050.1 - 1 9.7 26.6 2 8.7 0.1 6.1 8 0 0 8 8 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 EMC80050.1 - 1.1 9.2 12.5 3.2 7.8 0.0 5.0 4 1 2 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 EMC80050.1 - 2.1 8.1 17.3 4.2 7.1 0.4 5.2 4 1 1 5 5 5 0 TPR repeat Sel1 PF08238.12 EMC80050.1 - 3.7 8.4 11.3 2.9 8.7 0.3 4.4 5 0 0 5 5 5 0 Sel1 repeat zf-H2C2_2 PF13465.6 EMC80051.1 - 8.4e-53 174.6 69.1 1.7e-08 34.5 1.0 11.3 11 0 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.26 EMC80051.1 - 3.3e-36 121.7 88.2 0.00015 22.1 0.8 10.5 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC80051.1 - 5.4e-30 101.5 85.5 0.00045 20.8 0.9 10.7 11 0 0 11 11 10 10 C2H2-type zinc finger BTB PF00651.31 EMC80051.1 - 8.7e-22 77.4 2.2 1.9e-21 76.3 2.2 1.6 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_11 PF16622.5 EMC80051.1 - 5e-09 35.8 55.9 0.049 13.4 0.1 9.8 10 0 0 10 10 10 6 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 EMC80051.1 - 6.2e-09 35.9 52.5 0.12 12.7 0.4 10.1 10 0 0 10 10 10 6 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC80051.1 - 7.5e-08 32.5 63.5 0.043 14.2 0.2 10.4 11 0 0 11 11 10 5 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EMC80051.1 - 2.3e-06 27.4 82.7 0.016 15.2 3.0 10.5 10 0 0 10 10 10 5 C2H2-type zinc finger BolA PF01722.18 EMC80051.1 - 4.6e-05 23.6 12.8 0.018 15.3 1.1 4.8 2 1 2 4 4 4 2 BolA-like protein zf-C2H2_8 PF15909.5 EMC80051.1 - 0.0018 18.5 42.0 0.013 15.7 5.8 5.5 1 1 3 5 5 5 2 C2H2-type zinc ribbon zinc_ribbon_15 PF17032.5 EMC80051.1 - 0.0039 17.9 35.5 1.7 9.5 0.7 5.7 3 1 2 5 5 5 4 zinc-ribbon family HypA PF01155.19 EMC80051.1 - 0.0085 16.1 34.3 0.32 11.0 3.2 5.4 1 1 5 6 6 6 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_UBZ PF18439.1 EMC80051.1 - 0.023 14.3 38.8 5 6.8 0.3 9.1 9 0 0 9 9 9 0 Ubiquitin-Binding Zinc Finger DUF1415 PF07209.12 EMC80051.1 - 0.038 13.7 0.6 0.083 12.6 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1415) DUF3268 PF11672.8 EMC80051.1 - 0.04 14.2 22.8 0.55 10.6 0.2 4.8 4 0 0 4 4 4 0 zinc-finger-containing domain zf-H2C2_5 PF13909.6 EMC80051.1 - 0.12 12.1 0.1 0.12 12.1 0.1 10.4 9 2 0 9 9 7 0 C2H2-type zinc-finger domain Elong_Iki1 PF10483.9 EMC80051.1 - 1.3 8.4 4.4 1.1 8.7 1.8 2.0 1 1 0 2 2 2 0 Elongator subunit Iki1 LIM PF00412.22 EMC80051.1 - 3.4 8.0 54.1 5.2 7.4 7.0 7.5 3 1 5 8 8 8 0 LIM domain zf-H2C2_2 PF13465.6 EMC80052.1 - 4.8e-42 140.6 68.7 2.4e-09 37.2 0.5 10.8 10 0 0 10 10 10 8 Zinc-finger double domain zf-C2H2 PF00096.26 EMC80052.1 - 1.2e-33 113.7 66.8 4.5e-06 26.8 0.7 10.8 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC80052.1 - 2.6e-31 105.6 68.4 0.00069 20.2 0.5 10.7 10 0 0 10 10 10 10 C2H2-type zinc finger BTB PF00651.31 EMC80052.1 - 1.5e-23 83.2 2.5 2.9e-23 82.2 2.5 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_jaz PF12171.8 EMC80052.1 - 9e-15 54.5 40.0 0.053 13.8 0.3 10.3 11 0 0 11 11 10 7 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMC80052.1 - 1.2e-14 53.8 61.8 3.4e-08 33.3 0.7 10.7 10 0 0 10 10 10 5 C2H2-type zinc finger zf-met PF12874.7 EMC80052.1 - 1.2e-13 50.9 50.9 0.01 16.2 0.5 10.2 10 0 0 10 10 10 7 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 EMC80052.1 - 2.1e-09 36.9 40.4 0.00084 19.0 0.5 8.7 9 0 0 9 9 9 4 zinc-finger C2H2-type zf-C2HC_2 PF13913.6 EMC80052.1 - 0.00014 21.7 26.8 2 8.4 0.1 7.0 7 0 0 7 7 6 4 zinc-finger of a C2HC-type BolA PF01722.18 EMC80052.1 - 0.00021 21.5 3.7 6.6 7.1 0.3 5.3 2 2 4 6 6 6 1 BolA-like protein zf_UBZ PF18439.1 EMC80052.1 - 0.0029 17.1 34.5 1.2 8.8 0.1 9.3 10 0 0 10 10 10 4 Ubiquitin-Binding Zinc Finger BUD22 PF09073.10 EMC80052.1 - 0.026 13.9 21.8 0.037 13.4 21.8 1.1 1 0 0 1 1 1 0 BUD22 zinc_ribbon_15 PF17032.5 EMC80052.1 - 0.063 14.0 43.0 0.24 12.2 4.5 6.0 3 1 4 7 7 6 0 zinc-ribbon family ADK_lid PF05191.14 EMC80052.1 - 1.8 8.6 30.1 6.1 6.9 1.0 7.0 4 3 3 7 7 7 0 Adenylate kinase, active site lid Zn-ribbon_8 PF09723.10 EMC80052.1 - 2.2 8.5 57.7 0.033 14.3 3.5 9.0 6 2 4 10 10 9 0 Zinc ribbon domain Herpes_gE PF02480.16 EMC80054.1 - 0.0071 15.1 0.0 0.0075 15.1 0.0 1.1 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E Alpha_GJ PF03229.13 EMC80054.1 - 0.18 12.4 11.1 0.38 11.3 11.1 1.6 1 1 0 1 1 1 0 Alphavirus glycoprotein J 7tm_1 PF00001.21 EMC80055.1 - 3.4e-62 210.2 11.8 4.3e-62 209.8 11.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC80055.1 - 2.1e-15 56.8 3.9 2.6e-15 56.5 3.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC80055.1 - 3.2e-09 36.8 2.9 3.2e-09 36.8 2.9 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.9 EMC80055.1 - 0.00048 19.5 6.3 0.0037 16.6 0.1 2.4 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.6 EMC80055.1 - 0.0011 18.7 7.7 0.0031 17.3 7.7 1.6 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srv PF10323.9 EMC80055.1 - 0.0079 15.6 6.5 0.0059 16.0 3.8 1.9 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv Homeodomain PF00046.29 EMC80057.1 - 8.6e-17 60.7 1.0 2e-16 59.6 1.0 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC80057.1 - 0.059 13.3 0.7 0.19 11.6 0.0 2.2 3 0 0 3 3 3 0 Homeobox KN domain XRN_M PF17846.1 EMC80058.1 - 4.4e-167 556.5 0.0 5.9e-167 556.1 0.0 1.2 1 0 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 EMC80058.1 - 3.3e-94 314.8 0.0 6.6e-94 313.9 0.0 1.4 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus Rap_GAP PF02145.15 EMC80059.1 - 1.1e-45 155.5 0.0 2.3e-45 154.4 0.0 1.5 1 0 0 1 1 1 1 Rap/ran-GAP Ninjurin PF04923.12 EMC80059.1 - 0.066 13.1 0.3 0.31 11.0 0.1 2.2 2 0 0 2 2 2 0 Ninjurin DUF4821 PF16092.5 EMC80060.1 - 4.6e-92 308.4 4.3 6.3e-84 281.7 0.1 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4821) Pyr_redox_2 PF07992.14 EMC80060.1 - 2.8e-05 23.5 0.0 0.00012 21.4 0.0 1.9 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SQHop_cyclase_N PF13249.6 EMC80060.1 - 0.13 11.4 0.0 0.25 10.4 0.0 1.4 1 0 0 1 1 1 0 Squalene-hopene cyclase N-terminal domain HAT PF02184.16 EMC80061.1 - 9.3e-35 118.3 74.6 1.8e-09 37.4 0.3 15.2 14 2 0 14 14 14 8 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 EMC80061.1 - 4.1e-16 58.3 16.2 0.19 12.6 0.4 11.2 6 5 6 12 12 12 5 Tetratricopeptide repeat Suf PF05843.14 EMC80061.1 - 7.6e-10 39.2 41.8 0.00036 20.6 6.1 5.7 2 1 3 5 5 5 4 Suppressor of forked protein (Suf) TPR_19 PF14559.6 EMC80061.1 - 1.8e-08 34.8 6.9 0.0098 16.4 0.0 7.7 7 1 0 8 8 8 1 Tetratricopeptide repeat TPR_17 PF13431.6 EMC80061.1 - 3.6e-07 30.1 8.5 0.0013 18.9 0.0 6.5 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 EMC80061.1 - 1.8e-06 28.5 1.6 5.8 7.6 0.0 6.7 7 1 1 8 8 8 1 Tetratricopeptide repeat TPR_8 PF13181.6 EMC80061.1 - 0.0005 20.1 6.8 5.5 7.5 0.0 6.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMC80061.1 - 0.00062 20.0 5.2 6 7.2 0.0 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat NRDE-2 PF08424.10 EMC80061.1 - 0.0046 16.1 33.0 0.013 14.6 2.9 5.9 2 2 3 5 5 5 4 NRDE-2, necessary for RNA interference U3_assoc_6 PF08640.11 EMC80061.1 - 0.01 15.9 1.8 0.01 15.9 1.8 6.5 5 2 2 7 7 7 0 U3 small nucleolar RNA-associated protein 6 Mad3_BUB1_I PF08311.12 EMC80061.1 - 0.015 15.3 34.5 0.064 13.2 2.8 7.4 5 3 0 5 5 5 0 Mad3/BUB1 homology region 1 BSD PF03909.17 EMC80061.1 - 0.068 13.2 2.0 7.4 6.7 0.1 3.5 3 1 0 3 3 3 0 BSD domain TPR_2 PF07719.17 EMC80061.1 - 0.14 12.4 23.6 2.2 8.6 0.3 8.5 11 0 0 11 11 9 0 Tetratricopeptide repeat Na_Ca_ex PF01699.24 EMC80062.1 - 1.9e-58 196.7 40.5 3.8e-30 104.8 14.8 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein SPC25 PF06703.11 EMC80062.1 - 0.0033 17.2 2.5 0.021 14.6 0.1 2.6 2 0 0 2 2 2 1 Microsomal signal peptidase 25 kDa subunit (SPC25) RNA_pol_3_Rpc31 PF11705.8 EMC80062.1 - 0.011 16.1 5.5 0.016 15.5 5.5 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Herpes_LMP1 PF05297.11 EMC80062.1 - 0.013 14.7 0.4 0.013 14.7 0.4 3.1 3 0 0 3 3 3 0 Herpesvirus latent membrane protein 1 (LMP1) CENP-B_dimeris PF09026.10 EMC80062.1 - 0.027 14.8 9.1 0.065 13.6 9.1 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RXT2_N PF08595.11 EMC80062.1 - 0.058 13.4 1.9 0.1 12.7 1.9 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal NOA36 PF06524.12 EMC80062.1 - 0.083 12.2 7.3 0.13 11.6 7.3 1.2 1 0 0 1 1 1 0 NOA36 protein PBP1_TM PF14812.6 EMC80062.1 - 0.13 12.6 1.5 0.39 11.1 1.5 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PPP4R2 PF09184.11 EMC80062.1 - 0.16 11.6 6.0 0.25 10.9 6.0 1.2 1 0 0 1 1 1 0 PPP4R2 Cwf_Cwc_15 PF04889.12 EMC80062.1 - 0.54 10.0 8.1 0.82 9.3 8.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Astro_capsid_p PF12226.8 EMC80062.1 - 0.69 9.0 4.5 1.2 8.2 4.5 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein p53-inducible11 PF14936.6 EMC80062.1 - 2.4 8.2 7.4 0.68 10.0 3.6 2.0 2 0 0 2 2 2 0 Tumour protein p53-inducible protein 11 Ribosomal_60s PF00428.19 EMC80062.1 - 2.7 8.6 7.4 5.5 7.7 7.4 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein FAM176 PF14851.6 EMC80062.1 - 5.7 6.6 7.0 16 5.1 6.3 2.0 2 0 0 2 2 2 0 FAM176 family Ac76 PF05814.11 EMC80062.1 - 7.5 6.6 8.6 0.77 9.8 1.5 2.5 2 0 0 2 2 2 0 Orf76 (Ac76) Drf_FH1 PF06346.12 EMC80063.1 - 2 8.1 58.3 6.7 6.4 34.6 1.8 1 1 0 1 1 1 0 Formin Homology Region 1 VPS9 PF02204.18 EMC80065.1 - 2.8e-23 82.1 0.1 6.4e-23 80.9 0.1 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain SH2 PF00017.24 EMC80065.1 - 0.002 18.2 0.0 0.0079 16.3 0.0 2.1 2 0 0 2 2 2 1 SH2 domain VRP3 PF03536.15 EMC80065.1 - 0.016 14.8 0.1 0.029 13.9 0.1 1.3 1 0 0 1 1 1 0 Salmonella virulence-associated 28kDa protein RelB PF04221.12 EMC80065.1 - 0.095 12.7 0.0 0.25 11.3 0.0 1.7 1 0 0 1 1 1 0 RelB antitoxin Sushi PF00084.20 EMC80067.1 - 6.9e-10 39.4 0.4 6.9e-10 39.4 0.4 2.9 2 1 0 2 2 2 1 Sushi repeat (SCR repeat) Lectin_C PF00059.21 EMC80067.1 - 9e-07 29.6 0.7 9e-07 29.6 0.7 1.6 2 0 0 2 2 2 1 Lectin C-type domain Xlink PF00193.17 EMC80068.1 - 2.9e-59 197.5 0.7 4.2e-31 107.2 0.3 2.6 2 0 0 2 2 2 2 Extracellular link domain V-set PF07686.17 EMC80068.1 - 1.2e-15 57.6 0.1 3.4e-15 56.1 0.1 1.9 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC80068.1 - 0.0084 16.7 0.5 0.061 13.9 0.0 3.0 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 EMC80068.1 - 0.012 15.8 0.0 0.012 15.8 0.0 2.9 3 0 0 3 3 3 0 Immunoglobulin domain I-set PF07679.16 EMC80068.1 - 0.02 15.0 0.0 0.072 13.2 0.0 2.0 1 0 0 1 1 1 0 Immunoglobulin I-set domain Izumo-Ig PF16706.5 EMC80068.1 - 0.074 13.1 0.0 0.23 11.6 0.0 1.8 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain XRCC4 PF06632.12 EMC80069.1 - 1.3e-77 260.9 4.8 1.5e-77 260.8 4.8 1.0 1 0 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 Leu_zip PF15294.6 EMC80069.1 - 0.0013 18.3 3.6 0.0017 17.9 3.6 1.1 1 0 0 1 1 1 1 Leucine zipper Pox_A_type_inc PF04508.12 EMC80069.1 - 0.059 13.2 4.1 1.5 8.8 0.6 2.7 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat ZapB PF06005.12 EMC80069.1 - 0.13 12.7 6.5 1.1 9.8 5.9 2.2 1 1 1 2 2 2 0 Cell division protein ZapB DUF1242 PF06842.12 EMC80070.1 - 1.1e-19 69.9 3.4 1.9e-19 69.2 3.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) Pkinase PF00069.25 EMC80071.1 - 6e-57 193.0 0.0 1.2e-56 192.0 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC80071.1 - 1.9e-33 115.9 0.0 5.1e-33 114.4 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 EMC80071.1 - 3.1e-31 107.0 19.6 1.3e-16 60.1 6.3 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 EMC80071.1 - 2.4e-08 34.5 0.9 4.9e-08 33.6 0.9 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain C1_2 PF03107.16 EMC80071.1 - 5.6e-05 23.4 13.7 0.0013 19.0 3.0 2.5 2 0 0 2 2 2 2 C1 domain zf-RING-like PF08746.11 EMC80071.1 - 0.0012 19.1 19.3 0.044 14.1 6.7 2.7 2 0 0 2 2 2 2 RING-like domain Zf_RING PF16744.5 EMC80071.1 - 0.0029 17.7 1.5 0.0029 17.7 1.5 2.4 2 0 0 2 2 2 1 KIAA1045 RING finger Haspin_kinase PF12330.8 EMC80071.1 - 0.023 13.7 0.0 0.051 12.5 0.0 1.6 1 0 0 1 1 1 0 Haspin like kinase domain DZR PF12773.7 EMC80071.1 - 0.026 14.6 11.5 0.17 11.9 2.5 2.8 2 0 0 2 2 2 0 Double zinc ribbon zf-RING_9 PF13901.6 EMC80071.1 - 0.029 14.3 13.5 0.19 11.7 3.6 2.4 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon PHD PF00628.29 EMC80071.1 - 0.044 13.7 18.3 0.093 12.6 3.5 2.6 2 0 0 2 2 2 0 PHD-finger DUF2318 PF10080.9 EMC80071.1 - 0.31 11.2 13.8 0.47 10.6 4.8 2.5 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) Prok-RING_1 PF14446.6 EMC80071.1 - 0.44 10.5 12.6 1.7 8.6 3.0 3.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 CxC3 PF18804.1 EMC80071.1 - 0.58 10.0 5.8 0.94 9.3 0.5 3.0 3 0 0 3 3 3 0 CxC3 like cysteine cluster associated with KDZ transposases PHD_2 PF13831.6 EMC80071.1 - 0.95 9.1 11.2 1.5 8.4 1.6 2.8 2 0 0 2 2 2 0 PHD-finger PADR1 PF08063.12 EMC80071.1 - 1.9 8.4 11.4 0.053 13.3 2.8 2.6 2 0 0 2 2 2 0 PADR1 (NUC008) domain 6PF2K PF01591.18 EMC80072.1 - 2.2e-102 341.1 1.5 2.8e-102 340.7 0.7 1.5 2 0 0 2 2 2 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EMC80072.1 - 9.3e-43 146.2 0.0 1.3e-42 145.7 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EMC80072.1 - 4.8e-08 33.3 0.0 1.2e-07 32.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain Prefoldin PF02996.17 EMC80072.1 - 0.00075 19.4 1.0 0.0012 18.7 0.0 1.9 2 0 0 2 2 2 1 Prefoldin subunit KTI12 PF08433.10 EMC80072.1 - 0.0008 18.9 0.1 0.0015 18.1 0.1 1.6 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.6 EMC80072.1 - 0.013 16.0 0.0 0.028 15.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain His_Phos_2 PF00328.22 EMC80072.1 - 0.031 13.6 0.0 0.053 12.9 0.0 1.3 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) Zeta_toxin PF06414.12 EMC80072.1 - 0.071 12.4 0.0 0.22 10.8 0.0 2.0 1 1 0 1 1 1 0 Zeta toxin Arf PF00025.21 EMC80072.1 - 0.14 11.6 0.0 0.34 10.3 0.0 1.7 1 1 0 1 1 1 0 ADP-ribosylation factor family HSF_DNA-bind PF00447.17 EMC80073.1 - 7.4e-24 84.2 0.2 8.8e-24 84.0 0.2 1.1 1 0 0 1 1 1 1 HSF-type DNA-binding Glyco_hydro_56 PF01630.18 EMC80074.1 - 1.6e-133 444.8 0.5 1.9e-133 444.6 0.5 1.0 1 0 0 1 1 1 1 Hyaluronidase EGF_2 PF07974.13 EMC80074.1 - 0.29 11.5 13.1 3 8.3 2.8 2.5 2 0 0 2 2 2 0 EGF-like domain Glyco_hydro_56 PF01630.18 EMC80075.1 - 5.8e-145 482.5 0.1 6.8e-145 482.3 0.1 1.0 1 0 0 1 1 1 1 Hyaluronidase EGF PF00008.27 EMC80075.1 - 0.016 15.5 3.5 0.18 12.2 0.1 2.6 2 0 0 2 2 2 0 EGF-like domain HTH_20 PF12840.7 EMC80075.1 - 0.052 13.6 0.0 3.3 7.8 0.0 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain EGF_2 PF07974.13 EMC80075.1 - 1.1 9.7 13.7 5.4 7.5 5.1 2.6 2 0 0 2 2 2 0 EGF-like domain TUSC2 PF15000.6 EMC80076.1 - 4.9e-33 113.7 0.1 5.4e-33 113.6 0.1 1.0 1 0 0 1 1 1 1 Tumour suppressor candidate 2 RA PF00788.23 EMC80077.1 - 4e-16 59.4 1.7 6.9e-16 58.7 0.1 2.1 3 0 0 3 3 3 1 Ras association (RalGDS/AF-6) domain Ras_bdg_2 PF14847.6 EMC80077.1 - 0.043 14.1 0.0 0.085 13.2 0.0 1.4 1 0 0 1 1 1 0 Ras-binding domain of Byr2 FERM_N PF09379.10 EMC80077.1 - 0.084 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 FERM N-terminal domain zf-MYND PF01753.18 EMC80078.1 - 1.4e-09 37.8 19.6 1.4e-09 37.8 19.6 2.2 2 0 0 2 2 2 1 MYND finger zf-HIT PF04438.16 EMC80078.1 - 1.1 9.2 8.2 2 8.4 8.2 1.5 1 0 0 1 1 1 0 HIT zinc finger NPR2 PF06218.11 EMC80080.1 - 4.5e-53 180.6 4.8 1.1e-40 139.8 1.7 2.0 1 1 1 2 2 2 2 Nitrogen permease regulator 2 T4-gp15_tss PF16724.5 EMC80080.1 - 0.12 12.1 0.3 0.17 11.6 0.3 1.2 1 0 0 1 1 1 0 T4-like virus Myoviridae tail sheath stabiliser Cytochrom_B561 PF03188.16 EMC80081.1 - 4.8e-37 127.1 10.2 6.9e-37 126.6 10.2 1.2 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 CEP19 PF14933.6 EMC80083.1 - 0.053 13.8 0.0 0.068 13.5 0.0 1.1 1 0 0 1 1 1 0 CEP19-like protein Gram_pos_anchor PF00746.21 EMC80083.1 - 0.078 12.9 0.2 0.12 12.4 0.2 1.3 1 0 0 1 1 1 0 LPXTG cell wall anchor motif DUF2371 PF10177.9 EMC80083.1 - 0.14 12.3 0.0 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) LapA_dom PF06305.11 EMC80083.1 - 0.17 11.7 0.3 0.33 10.8 0.3 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain MTS PF05175.14 EMC80084.1 - 2.2e-13 50.1 0.0 1e-12 47.9 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase small domain Methyltransf_31 PF13847.6 EMC80084.1 - 1.1e-09 38.2 0.0 1.8e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmC_N PF17827.1 EMC80084.1 - 4.4e-09 36.8 0.1 1.3e-08 35.3 0.0 1.9 2 0 0 2 2 1 1 PrmC N-terminal domain Methyltransf_25 PF13649.6 EMC80084.1 - 1.4e-08 35.4 0.0 2.9e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 EMC80084.1 - 5e-08 32.8 0.0 1.2e-07 31.6 0.0 1.5 2 0 0 2 2 2 1 Conserved hypothetical protein 95 PrmA PF06325.13 EMC80084.1 - 8e-08 32.0 0.0 1.3e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 EMC80084.1 - 6.3e-06 25.8 0.0 3.1e-05 23.5 0.0 2.1 3 0 0 3 3 3 1 Putative methyltransferase UPF0020 PF01170.18 EMC80084.1 - 2e-05 24.4 0.0 5.9e-05 22.8 0.0 1.7 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_12 PF08242.12 EMC80084.1 - 0.00011 22.9 0.0 0.00017 22.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC80084.1 - 0.00016 22.3 0.0 0.00031 21.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 EMC80084.1 - 0.00092 20.2 0.1 0.0021 19.1 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EMC80084.1 - 0.001 19.0 0.1 0.0019 18.1 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltr_RsmB-F PF01189.17 EMC80084.1 - 0.0018 18.0 0.0 0.0034 17.0 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_15 PF09445.10 EMC80084.1 - 0.0036 16.9 0.0 0.0065 16.1 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_16 PF10294.9 EMC80084.1 - 0.0081 15.9 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EMC80084.1 - 0.014 15.2 0.0 0.044 13.6 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 EMC80084.1 - 0.031 14.3 0.0 0.053 13.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain N6_N4_Mtase PF01555.18 EMC80084.1 - 0.042 13.5 0.0 0.24 11.1 0.0 2.0 2 0 0 2 2 2 0 DNA methylase Methyltransf_3 PF01596.17 EMC80084.1 - 0.047 12.8 0.0 0.074 12.2 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase PCMT PF01135.19 EMC80084.1 - 0.076 12.8 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.20 EMC80084.1 - 0.11 11.6 0.0 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PRMT5 PF05185.16 EMC80084.1 - 0.12 12.2 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase GCD14 PF08704.10 EMC80084.1 - 0.14 11.8 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit DUF938 PF06080.12 EMC80084.1 - 0.16 11.7 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) SH2 PF00017.24 EMC80085.1 - 1.4e-13 50.8 0.0 2.3e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.16 EMC80085.1 - 3.7e-12 46.4 0.7 1.1e-11 44.8 0.7 1.9 1 0 0 1 1 1 1 SOCS box SH2_2 PF14633.6 EMC80085.1 - 0.19 11.1 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 SH2 domain Pkinase PF00069.25 EMC80086.1 - 1.5e-68 231.0 0.0 2.4e-68 230.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC80086.1 - 1.2e-29 103.4 0.0 1.8e-29 102.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMC80086.1 - 1.9e-07 30.6 0.2 3.5e-07 29.8 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMC80086.1 - 0.0019 17.1 0.1 0.0046 15.8 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EMC80086.1 - 0.0019 17.6 0.0 0.004 16.5 0.0 1.6 1 0 0 1 1 1 1 Kinase-like PAXIP1_C PF15364.6 EMC80086.1 - 0.042 14.2 0.7 0.27 11.5 0.2 2.5 3 0 0 3 3 3 0 PAXIP1-associated-protein-1 C term PTIP binding protein VF530 PF09905.9 EMC80086.1 - 0.056 13.6 0.0 0.49 10.6 0.0 2.3 2 0 0 2 2 2 0 DNA-binding protein VF530 Choline_kinase PF01633.20 EMC80086.1 - 0.086 12.4 0.0 0.34 10.5 0.0 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase DHR-2 PF06920.13 EMC80087.1 - 3.4e-133 445.1 5.8 3.4e-133 445.1 5.8 2.3 3 0 0 3 3 3 1 Dock homology region 2 DOCK_N PF16172.5 EMC80087.1 - 6.2e-101 338.0 0.3 1.1e-100 337.2 0.3 1.4 1 0 0 1 1 1 1 DOCK N-terminus DOCK-C2 PF14429.6 EMC80087.1 - 2.4e-56 190.7 0.0 6.3e-56 189.3 0.0 1.8 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins Armet PF10208.9 EMC80088.1 - 2e-69 232.1 3.5 2.3e-69 232.0 3.5 1.0 1 0 0 1 1 1 1 Degradation arginine-rich protein for mis-folding CheZ PF04344.13 EMC80088.1 - 0.0054 16.7 0.0 0.0062 16.5 0.0 1.2 1 0 0 1 1 1 1 Chemotaxis phosphatase, CheZ Cauli_DNA-bind PF03310.13 EMC80088.1 - 0.033 14.2 1.4 0.057 13.5 1.4 1.5 1 0 0 1 1 1 0 Caulimovirus DNA-binding protein HeH PF12949.7 EMC80088.1 - 0.04 13.6 0.2 0.1 12.3 0.1 1.8 2 0 0 2 2 2 0 HeH/LEM domain Hamartin PF04388.12 EMC80088.1 - 0.059 12.0 0.0 0.069 11.8 0.0 1.1 1 0 0 1 1 1 0 Hamartin protein Epsilon_antitox PF08998.11 EMC80088.1 - 0.17 12.1 0.0 0.28 11.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial epsilon antitoxin LisH PF08513.11 EMC80089.1 - 0.02 14.8 0.1 0.24 11.4 0.0 2.7 3 0 0 3 3 3 0 LisH ANAPC4_WD40 PF12894.7 EMC80089.1 - 0.065 13.5 0.0 0.25 11.7 0.0 2.0 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain DUF913 PF06025.12 EMC80089.1 - 7.8 5.4 8.4 20 4.0 0.0 2.7 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) Sema PF01403.19 EMC80090.1 - 3e-121 405.2 0.0 3.6e-69 233.6 0.0 2.1 2 0 0 2 2 2 2 Sema domain Ig_3 PF13927.6 EMC80090.1 - 4.2e-06 27.3 0.0 9.2e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC80090.1 - 3e-05 24.1 0.0 5.8e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC80090.1 - 3.2e-05 23.9 0.0 5.6e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain PSI PF01437.25 EMC80090.1 - 0.0021 18.6 9.2 0.0054 17.2 9.2 1.7 1 0 0 1 1 1 1 Plexin repeat V-set PF07686.17 EMC80090.1 - 0.0066 16.6 0.0 0.026 14.7 0.0 2.0 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.6 EMC80090.1 - 0.046 14.1 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain OCRE PF17780.1 EMC80091.1 - 7.8e-21 73.8 2.0 1.7e-20 72.8 2.0 1.6 1 0 0 1 1 1 1 OCRE domain G-patch PF01585.23 EMC80091.1 - 1.9e-05 24.5 1.8 5.9e-05 22.9 1.8 1.9 1 1 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EMC80091.1 - 0.072 13.2 1.3 0.32 11.1 1.3 2.2 1 0 0 1 1 1 0 G-patch domain RRM_1 PF00076.22 EMC80091.1 - 0.094 12.5 0.0 3 7.7 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2_jaz PF12171.8 EMC80091.1 - 0.11 12.8 0.3 0.35 11.2 0.3 1.9 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Mon1 PF03164.14 EMC80092.1 - 5.9e-144 480.1 0.1 6.9e-144 479.9 0.1 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 Pkinase PF00069.25 EMC80093.1 - 4.2e-46 157.4 0.0 4.7e-46 157.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC80093.1 - 3.8e-21 75.6 0.0 4.6e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC80093.1 - 2.6e-05 23.7 0.1 0.0027 17.1 0.0 2.3 2 1 0 2 2 2 2 Kinase-like Kdo PF06293.14 EMC80093.1 - 0.017 14.5 0.0 0.025 13.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Tropomyosin_1 PF12718.7 EMC80094.1 - 0.016 15.4 10.4 0.016 15.4 10.4 2.7 2 1 0 2 2 2 0 Tropomyosin like T3SSipB PF16535.5 EMC80094.1 - 0.016 15.7 0.6 0.016 15.7 0.6 3.0 2 1 0 2 2 2 0 Type III cell invasion protein SipB Laminin_II PF06009.12 EMC80094.1 - 0.016 15.2 6.1 0.016 15.2 6.1 2.7 2 1 0 2 2 2 0 Laminin Domain II HIP1_clath_bdg PF16515.5 EMC80094.1 - 0.15 12.7 31.9 0.13 12.8 7.0 3.6 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 APG17 PF04108.12 EMC80094.1 - 0.21 10.6 17.9 0.45 9.6 6.1 2.4 1 1 1 2 2 2 0 Autophagy protein Apg17 Spc7 PF08317.11 EMC80094.1 - 0.24 10.2 34.5 0.04 12.8 13.7 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein GAS PF13851.6 EMC80094.1 - 0.4 10.0 37.0 1.9 7.8 14.2 2.7 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding MAD PF05557.13 EMC80094.1 - 0.54 8.6 32.1 0.051 11.9 24.8 1.9 1 1 1 2 2 2 0 Mitotic checkpoint protein HMMR_N PF15905.5 EMC80094.1 - 0.76 9.2 38.4 2.7 7.4 13.7 2.7 1 1 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Filament PF00038.21 EMC80094.1 - 0.84 9.2 29.5 2 7.9 29.5 1.5 1 1 0 1 1 1 0 Intermediate filament protein WEMBL PF05701.11 EMC80094.1 - 1.2 7.7 29.2 7.7 5.1 18.4 2.7 1 1 2 3 3 3 0 Weak chloroplast movement under blue light DUF1664 PF07889.12 EMC80094.1 - 1.6 8.8 21.7 0.55 10.3 6.7 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) MscS_porin PF12795.7 EMC80094.1 - 2.7 7.5 26.1 0.31 10.6 6.7 2.3 1 1 0 2 2 2 0 Mechanosensitive ion channel porin domain Fez1 PF06818.15 EMC80094.1 - 3.1 8.2 30.0 6.5 7.2 9.7 2.3 1 1 1 2 2 2 0 Fez1 Occludin_ELL PF07303.13 EMC80094.1 - 4.8 8.0 18.3 2.1 9.1 5.4 2.8 2 1 0 2 2 2 0 Occludin homology domain Jnk-SapK_ap_N PF09744.9 EMC80094.1 - 5.5 7.2 33.3 16 5.7 12.2 2.8 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 FmiP_Thoc5 PF09766.9 EMC80094.1 - 6.8 5.9 23.1 0.057 12.7 6.1 2.3 2 0 0 2 2 2 0 Fms-interacting protein/Thoc5 CENP-F_leu_zip PF10473.9 EMC80094.1 - 7 6.7 38.5 18 5.3 10.4 3.2 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BST2 PF16716.5 EMC80094.1 - 8.4 7.1 28.9 3.5 8.3 7.7 3.9 1 1 3 4 4 4 0 Bone marrow stromal antigen 2 MCPsignal PF00015.21 EMC80094.1 - 9.6 6.0 7.8 1.1 9.0 1.4 2.3 1 1 2 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Myosin_head PF00063.21 EMC80096.1 - 2.2e-288 958.2 4.7 2.2e-288 958.2 4.7 2.2 2 0 0 2 2 2 1 Myosin head (motor domain) DIL PF01843.19 EMC80096.1 - 2.2e-32 111.4 1.6 2.2e-32 111.4 1.6 3.2 3 0 0 3 3 3 1 DIL domain IQ PF00612.27 EMC80096.1 - 1.2e-24 83.7 42.6 9.3e-05 21.9 3.5 6.8 6 0 0 6 6 6 6 IQ calmodulin-binding motif Csm1_N PF18504.1 EMC80096.1 - 0.0033 17.7 3.0 0.0033 17.7 3.0 8.9 8 1 0 8 8 8 1 Csm1 N-terminal domain AAA_22 PF13401.6 EMC80096.1 - 0.013 15.8 0.0 0.086 13.1 0.0 2.5 1 0 0 1 1 1 0 AAA domain HTH_17 PF12728.7 EMC80096.1 - 0.02 15.1 0.1 4.2 7.6 0.0 3.9 3 0 0 3 3 3 0 Helix-turn-helix domain Myosin_N PF02736.19 EMC80096.1 - 0.025 14.4 0.2 0.065 13.1 0.2 1.7 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain AAA_16 PF13191.6 EMC80096.1 - 0.13 12.6 0.0 0.13 12.6 0.0 3.4 4 0 0 4 4 4 0 AAA ATPase domain Endosulfine PF04667.17 EMC80097.1 - 5e-11 42.6 1.3 6.7e-11 42.2 1.3 1.2 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Ntox30 PF15532.6 EMC80097.1 - 0.054 13.9 0.0 0.067 13.6 0.0 1.2 1 0 0 1 1 1 0 Bacterial toxin 30 Chromosome_seg PF13889.6 EMC80098.1 - 2.4e-19 69.2 0.3 5.3e-19 68.1 0.3 1.6 1 0 0 1 1 1 1 Chromosome segregation during meiosis DUF4210 PF13915.6 EMC80098.1 - 1.7e-13 51.0 0.1 4.9e-13 49.5 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) CUT PF02376.15 EMC80099.1 - 7.5e-32 109.3 0.7 1.1e-31 108.8 0.7 1.3 1 0 0 1 1 1 1 CUT domain Homeodomain PF00046.29 EMC80099.1 - 2.3e-10 40.2 0.7 4.5e-10 39.2 0.7 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC80099.1 - 0.00062 19.6 0.0 0.0017 18.2 0.0 1.7 1 0 0 1 1 1 1 Homeobox KN domain C2 PF00168.30 EMC80100.1 - 2.8e-07 30.7 0.0 3.7e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 C2 domain Membr_traf_MHD PF10540.9 EMC80101.1 - 2.7e-50 170.4 0.9 1.7e-49 167.8 0.9 2.6 1 0 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 EMC80101.1 - 4.8e-43 145.7 5.2 9.9e-27 93.2 0.3 3.3 3 0 0 3 3 2 2 C2 domain DUF1041 PF06292.17 EMC80101.1 - 7.4e-34 116.3 0.4 7.4e-34 116.3 0.4 3.2 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1041) C1_1 PF00130.22 EMC80101.1 - 5.3e-11 42.2 6.2 1.2e-10 41.2 6.2 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Med9 PF07544.13 EMC80101.1 - 0.011 15.7 0.5 0.067 13.3 0.5 2.4 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 FlaC_arch PF05377.11 EMC80101.1 - 0.02 15.3 2.5 0.16 12.4 2.5 2.7 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Mrr_N PF14338.6 EMC80101.1 - 0.073 13.2 0.1 0.67 10.1 0.1 2.8 2 0 0 2 2 2 0 Mrr N-terminal domain DUF2205 PF10224.9 EMC80101.1 - 0.088 12.8 0.5 0.44 10.6 0.5 2.3 1 0 0 1 1 1 0 Short coiled-coil protein AKNA PF12443.8 EMC80101.1 - 0.11 13.1 1.6 1.5 9.5 0.4 3.2 2 0 0 2 2 2 0 AT-hook-containing transcription factor EzrA PF06160.12 EMC80101.1 - 0.39 8.8 11.5 0.079 11.1 0.5 2.7 3 0 0 3 3 3 0 Septation ring formation regulator, EzrA DUF2730 PF10805.8 EMC80101.1 - 1.1 9.4 3.1 2.8 8.1 0.2 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) COG5 PF10392.9 EMC80101.1 - 3.2 8.0 5.7 1 9.6 0.2 3.0 3 0 0 3 3 3 0 Golgi transport complex subunit 5 DUF1664 PF07889.12 EMC80101.1 - 8.3 6.5 11.5 0.16 12.0 0.6 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) Ribosomal_L24e PF01246.20 EMC80102.1 - 4.8e-14 52.3 6.5 4.8e-14 52.3 6.5 2.0 2 0 0 2 2 2 1 Ribosomal protein L24e DUF1091 PF06477.13 EMC80102.1 - 0.055 14.0 0.5 0.096 13.2 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1091) Ras PF00071.22 EMC80103.1 - 1.7e-57 193.5 0.0 2e-57 193.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC80103.1 - 3.2e-31 108.0 0.0 5e-31 107.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC80103.1 - 9.7e-12 44.7 0.0 1.3e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EMC80103.1 - 0.00011 22.2 0.2 0.22 11.4 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EMC80103.1 - 0.00029 20.4 0.0 0.00069 19.2 0.0 1.7 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EMC80103.1 - 0.00067 19.7 0.0 0.0011 19.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EMC80103.1 - 0.045 13.3 0.0 1.4 8.4 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B ATP-grasp_5 PF13549.6 EMC80103.1 - 0.1 12.0 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 ATP-grasp domain TPP_enzyme_M PF00205.22 EMC80103.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain SRPRB PF09439.10 EMC80103.1 - 0.15 11.5 0.0 0.55 9.6 0.0 1.8 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit DUF1664 PF07889.12 EMC80104.1 - 0.014 15.4 25.2 0.38 10.8 5.0 4.4 3 1 2 5 5 5 0 Protein of unknown function (DUF1664) HbrB PF08539.11 EMC80104.1 - 0.026 14.5 0.1 0.026 14.5 0.1 2.8 3 0 0 3 3 3 0 HbrB-like MTABC_N PF16185.5 EMC80104.1 - 0.75 9.2 1.6 2.2 7.7 0.0 2.3 2 1 0 2 2 2 0 Mitochondrial ABC-transporter N-terminal five TM region DUF3573 PF12097.8 EMC80104.1 - 0.88 8.3 2.5 2.7 6.7 2.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) ApoO PF09769.9 EMC80104.1 - 0.93 9.5 8.5 6.2 6.8 0.8 3.0 2 0 0 2 2 2 0 Apolipoprotein O Csm1_N PF18504.1 EMC80104.1 - 3.9 7.9 42.2 0.077 13.4 5.4 6.7 3 1 3 6 6 6 0 Csm1 N-terminal domain DUF948 PF06103.11 EMC80104.1 - 5.8 7.2 7.4 15 5.9 0.2 3.5 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) RVT_1 PF00078.27 EMC80105.1 - 0.016 14.8 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) PHD PF00628.29 EMC80106.1 - 7.5e-07 28.9 5.7 1.3e-06 28.2 5.7 1.4 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.6 EMC80106.1 - 0.0023 17.8 1.1 0.0058 16.5 1.1 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 zf-RING_2 PF13639.6 EMC80106.1 - 0.056 13.8 4.5 0.11 12.8 4.5 1.5 1 0 0 1 1 1 0 Ring finger domain PHD_4 PF16866.5 EMC80106.1 - 0.39 10.8 5.1 1.3 9.2 5.1 2.0 1 1 0 1 1 1 0 PHD-finger zf-RING_11 PF17123.5 EMC80106.1 - 0.68 9.7 4.6 1.4 8.8 4.6 1.5 1 0 0 1 1 1 0 RING-like zinc finger FANCL_C PF11793.8 EMC80106.1 - 1.6 9.0 5.1 1 9.6 2.7 1.9 2 0 0 2 2 2 0 FANCL C-terminal domain Macoilin PF09726.9 EMC80106.1 - 3.4 6.1 9.1 4.1 5.8 9.1 1.0 1 0 0 1 1 1 0 Macoilin family SWI-SNF_Ssr4 PF08549.10 EMC80106.1 - 4.4 5.8 11.8 5.7 5.5 11.8 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) PALP PF00291.25 EMC80107.1 - 3e-59 200.8 0.2 3.6e-59 200.6 0.2 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ACT_6 PF13740.6 EMC80107.1 - 0.00097 19.1 0.0 0.0027 17.7 0.0 1.7 1 0 0 1 1 1 1 ACT domain DUF4499 PF14934.6 EMC80108.1 - 5.2e-31 106.8 7.3 6e-31 106.6 7.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4499) RIBIOP_C PF04950.12 EMC80109.1 - 4.6e-97 325.0 0.0 4.6e-97 325.0 0.0 3.4 4 0 0 4 4 4 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EMC80109.1 - 1.8e-30 104.8 0.0 1.1e-29 102.4 0.0 2.5 1 0 0 1 1 1 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.27 EMC80109.1 - 3.2e-06 26.8 0.1 0.00057 19.5 0.0 3.2 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EMC80109.1 - 0.00065 19.8 0.3 0.0069 16.5 0.1 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA PF00004.29 EMC80109.1 - 0.012 16.1 0.1 0.034 14.6 0.1 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EMC80109.1 - 0.014 15.8 0.8 0.032 14.6 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain Gly_acyl_tr_C PF08444.10 EMC80109.1 - 0.043 14.0 0.0 0.2 11.9 0.0 2.2 2 0 0 2 2 2 0 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region AAA_22 PF13401.6 EMC80109.1 - 0.049 13.9 0.0 0.14 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EMC80109.1 - 0.1 13.0 0.0 0.31 11.5 0.0 1.8 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 EMC80109.1 - 1.1 9.7 0.0 1.1 9.7 0.0 3.4 4 1 0 4 4 4 0 ABC transporter Pkinase_Tyr PF07714.17 EMC80110.1 - 2.1e-104 348.4 0.0 3e-104 347.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RET_CLD1 PF17756.1 EMC80110.1 - 7.4e-55 184.6 0.0 1.9e-53 180.1 0.0 3.0 3 0 0 3 3 3 1 RET Cadherin like domain 1 RET_CLD3 PF17812.1 EMC80110.1 - 3e-54 182.2 0.1 7.2e-54 181.0 0.1 1.7 1 0 0 1 1 1 1 RET Cadherin like domain 3 Pkinase PF00069.25 EMC80110.1 - 5.8e-46 157.0 0.0 1.2e-45 156.0 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain RET_CLD4 PF17813.1 EMC80110.1 - 8.9e-46 154.5 1.0 3.7e-45 152.5 0.6 2.3 2 0 0 2 2 2 1 RET Cadherin like domain 4 Cadherin PF00028.17 EMC80110.1 - 6e-19 68.3 0.4 4.7e-09 36.6 0.0 5.0 4 1 0 4 4 4 2 Cadherin domain Cadherin_2 PF08266.12 EMC80110.1 - 0.013 15.3 0.6 0.97 9.3 0.0 2.9 3 0 0 3 3 3 0 Cadherin-like RIO1 PF01163.22 EMC80110.1 - 0.03 13.9 0.0 0.17 11.4 0.0 2.0 2 0 0 2 2 2 0 RIO1 family Pkinase_fungal PF17667.1 EMC80110.1 - 0.085 11.6 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 EMC80110.1 - 0.1 11.5 0.0 0.21 10.5 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain CHGN PF05679.16 EMC80111.1 - 2.2e-84 284.1 0.2 2.9e-84 283.7 0.2 1.1 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Glyco_transf_7C PF02709.14 EMC80111.1 - 3.1e-08 33.2 0.2 7.4e-08 31.9 0.2 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase KfrA_N PF11740.8 EMC80111.1 - 0.0009 19.9 0.3 0.0015 19.2 0.3 1.3 1 0 0 1 1 1 1 Plasmid replication region DNA-binding N-term Glyco_tranf_2_2 PF10111.9 EMC80111.1 - 0.0037 16.8 0.3 1.5 8.2 0.0 2.2 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Atg14 PF10186.9 EMC80111.1 - 0.079 12.0 3.8 0.13 11.4 3.8 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fmp27_WPPW PF10359.9 EMC80111.1 - 0.084 11.7 2.1 0.12 11.3 2.1 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain SlyX PF04102.12 EMC80111.1 - 0.14 12.8 2.7 0.39 11.4 2.7 1.7 1 0 0 1 1 1 0 SlyX Csm1_N PF18504.1 EMC80111.1 - 0.16 12.4 4.4 0.39 11.1 4.4 1.7 1 0 0 1 1 1 0 Csm1 N-terminal domain Allexi_40kDa PF05549.11 EMC80111.1 - 0.16 11.5 0.8 0.3 10.6 0.8 1.3 1 0 0 1 1 1 0 Allexivirus 40kDa protein TMPIT PF07851.13 EMC80111.1 - 0.32 10.2 2.2 0.6 9.3 2.2 1.3 1 0 0 1 1 1 0 TMPIT-like protein FapA PF03961.13 EMC80111.1 - 0.42 9.2 2.7 0.63 8.6 2.7 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Prefoldin PF02996.17 EMC80111.1 - 0.45 10.4 5.0 0.33 10.9 2.8 1.9 2 0 0 2 2 2 0 Prefoldin subunit Fib_alpha PF08702.10 EMC80111.1 - 0.77 9.9 4.3 1.7 8.8 4.3 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF4140 PF13600.6 EMC80111.1 - 0.86 10.1 3.3 1.8 9.0 3.3 1.5 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) DUF4407 PF14362.6 EMC80111.1 - 2.7 7.2 7.9 0.052 12.9 0.5 1.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4407) Cnn_1N PF07989.11 EMC80111.1 - 4 7.7 8.7 1.9 8.7 6.1 1.8 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 DUF5320 PF17253.2 EMC80111.1 - 5.5 8.1 6.2 0.45 11.6 0.4 2.3 3 0 0 3 3 1 0 Family of unknown function (DUF5320) RasGEF PF00617.19 EMC80112.1 - 2.7e-46 158.0 3.2 2.7e-46 158.0 3.2 2.2 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EMC80112.1 - 1.7e-19 70.0 0.2 5.6e-19 68.3 0.1 1.9 2 0 0 2 2 2 1 RasGEF N-terminal motif H2TH PF06831.14 EMC80112.1 - 0.037 14.0 0.0 14 5.8 0.0 2.9 2 0 0 2 2 2 0 Formamidopyrimidine-DNA glycosylase H2TH domain RRT14 PF17075.5 EMC80112.1 - 0.077 13.1 2.5 0.18 11.9 2.5 1.6 1 0 0 1 1 1 0 Regular of rDNA transcription protein 14 VHS PF00790.19 EMC80112.1 - 0.086 12.7 1.7 1.2 8.9 0.2 2.4 1 1 1 2 2 2 0 VHS domain Rb_C PF08934.10 EMC80112.1 - 0.13 12.1 0.4 0.23 11.3 0.4 1.4 1 0 0 1 1 1 0 Rb C-terminal domain Lectin_C PF00059.21 EMC80113.1 - 1.7e-24 86.6 0.2 2e-24 86.4 0.2 1.1 1 0 0 1 1 1 1 Lectin C-type domain Imm32 PF15566.6 EMC80113.1 - 0.025 14.4 0.0 0.047 13.5 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 32 Pex26 PF07163.12 EMC80113.1 - 0.23 10.7 0.0 0.27 10.5 0.0 1.1 1 0 0 1 1 1 0 Pex26 protein Lectin_C PF00059.21 EMC80114.1 - 6.2e-18 65.5 0.5 7.9e-18 65.2 0.5 1.1 1 0 0 1 1 1 1 Lectin C-type domain Pox_E6 PF04656.12 EMC80114.1 - 0.18 10.2 0.0 0.26 9.7 0.0 1.2 1 0 0 1 1 1 0 Pox virus E6 protein S-AdoMet_synt_C PF02773.16 EMC80116.1 - 2.1e-68 228.6 0.1 4.3e-68 227.6 0.1 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 EMC80116.1 - 2.8e-46 156.6 0.0 5.5e-46 155.7 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 EMC80116.1 - 4.8e-44 149.1 0.1 1.1e-43 147.9 0.1 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 EMC80116.1 - 0.028 13.2 0.3 0.089 11.6 0.2 1.7 1 1 1 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) Dpy-30 PF05186.13 EMC80117.1 - 1.2e-12 47.3 0.0 1.8e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 Dpy-30 motif HAT_KAT11 PF08214.11 EMC80117.1 - 0.43 9.8 4.1 0.49 9.6 4.1 1.1 1 0 0 1 1 1 0 Histone acetylation protein DUF5401 PF17380.2 EMC80117.1 - 4.6 5.2 22.2 5.6 4.9 22.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) KH_6 PF15985.5 EMC80118.1 - 6.5e-17 61.6 0.0 1e-16 61.0 0.0 1.3 1 0 0 1 1 1 1 KH domain UPF0444 PF15475.6 EMC80119.1 - 0.081 13.2 0.2 0.12 12.7 0.2 1.3 1 0 0 1 1 1 0 Transmembrane protein C12orf23, UPF0444 Tetraspanin PF00335.20 EMC80120.1 - 5.6e-56 189.8 7.5 6.3e-56 189.6 7.5 1.0 1 0 0 1 1 1 1 Tetraspanin family SH2 PF00017.24 EMC80121.1 - 3.9e-16 58.9 0.1 1.2e-15 57.4 0.1 1.9 1 0 0 1 1 1 1 SH2 domain FYVE PF01363.21 EMC80122.1 - 4.5e-16 58.8 18.9 1.5e-15 57.1 18.9 2.0 1 0 0 1 1 1 1 FYVE zinc finger RUN PF02759.19 EMC80122.1 - 2.4e-08 34.0 0.2 2.4e-08 34.0 0.2 5.2 4 3 0 4 4 4 1 RUN domain GOLD_2 PF13897.6 EMC80122.1 - 0.00013 22.4 0.0 0.00013 22.4 0.0 5.9 6 4 2 8 8 8 1 Golgi-dynamics membrane-trafficking 7tm_1 PF00001.21 EMC80123.1 - 9.3e-42 143.2 23.2 1.4e-41 142.6 23.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF621 PF04789.15 EMC80123.1 - 4.4 6.4 25.8 10 5.2 25.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF621) DDE_Tnp_1_6 PF13751.6 EMC80124.1 - 0.24 11.6 4.8 0.48 10.6 4.8 1.4 1 0 0 1 1 1 0 Transposase DDE domain DUF4778 PF16008.5 EMC80124.1 - 1.4 9.0 8.6 2.9 7.9 8.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) Macoilin PF09726.9 EMC80124.1 - 8.9 4.7 30.5 0.047 12.2 20.7 2.0 2 1 0 2 2 2 0 Macoilin family ATG16 PF08614.11 EMC80125.1 - 0.0009 19.5 30.7 0.025 14.8 5.7 3.1 1 1 2 3 3 3 2 Autophagy protein 16 (ATG16) PEARLI-4 PF05278.12 EMC80125.1 - 0.015 14.9 5.2 1.5 8.3 0.6 2.4 2 0 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) PKcGMP_CC PF16808.5 EMC80125.1 - 0.051 13.4 14.3 1.3 9.0 0.2 4.7 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase APG6_N PF17675.1 EMC80125.1 - 0.064 13.8 31.4 0.038 14.5 10.6 3.3 2 1 1 3 3 3 0 Apg6 coiled-coil region TSC22 PF01166.18 EMC80125.1 - 0.07 13.4 8.9 0.83 10.0 0.4 3.7 3 2 0 3 3 3 0 TSC-22/dip/bun family GIT_CC PF16559.5 EMC80125.1 - 0.074 12.9 0.3 0.074 12.9 0.3 3.6 5 1 1 6 6 6 0 GIT coiled-coil Rho guanine nucleotide exchange factor Spc7 PF08317.11 EMC80125.1 - 0.12 11.2 23.9 0.47 9.3 9.7 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein Lebercilin PF15619.6 EMC80125.1 - 0.23 11.1 25.7 0.57 9.8 25.6 1.8 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease CCDC144C PF14915.6 EMC80125.1 - 0.38 9.8 26.5 7.8 5.5 26.1 2.4 1 1 1 2 2 2 0 CCDC144C protein coiled-coil region ADIP PF11559.8 EMC80125.1 - 0.84 9.7 26.5 0.56 10.3 9.0 2.8 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.9 EMC80125.1 - 2 8.5 28.5 0.11 12.5 8.2 3.0 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Bacillus_HBL PF05791.11 EMC80125.1 - 5.1 6.9 16.2 0.46 10.3 2.2 2.7 3 0 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) HAUS-augmin3 PF14932.6 EMC80125.1 - 6 6.4 25.5 3.1 7.3 9.9 2.6 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 COQ7 PF03232.13 EMC80125.1 - 6.2 6.6 8.0 13 5.5 0.1 3.4 2 1 1 3 3 3 0 Ubiquinone biosynthesis protein COQ7 YabA PF06156.13 EMC80125.1 - 9.8 6.9 16.9 8.4 7.1 2.7 3.3 1 1 2 3 3 3 0 Initiation control protein YabA Prefoldin_3 PF13758.6 EMC80125.1 - 9.8 6.3 9.4 1.3 9.1 0.9 3.3 2 2 2 4 4 4 0 Prefoldin subunit Zfx_Zfy_act PF04704.13 EMC80126.1 - 2.3e-143 477.3 35.8 7.8e-143 475.5 30.3 2.9 2 1 0 2 2 2 1 Zfx / Zfy transcription activation region zf-C2H2 PF00096.26 EMC80126.1 - 5.2e-41 136.8 117.4 2.7e-06 27.5 2.9 12.3 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC80126.1 - 3.8e-36 121.9 118.6 1.7e-06 28.2 4.6 13.1 13 0 0 13 13 13 11 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC80126.1 - 5.4e-32 107.7 110.8 0.00011 22.7 2.3 12.4 12 0 0 12 12 12 12 C2H2-type zinc finger zf-H2C2_5 PF13909.6 EMC80126.1 - 2.2e-27 94.5 103.4 3.8e-07 29.7 0.9 12.4 12 0 0 12 12 12 9 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 EMC80126.1 - 9.2e-12 44.9 82.4 0.017 15.4 0.1 11.8 12 0 0 12 12 12 7 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.5 EMC80126.1 - 1.4e-07 32.2 48.1 0.013 16.2 2.7 7.1 4 2 3 7 7 7 4 zinc-ribbon family zf-met PF12874.7 EMC80126.1 - 0.0022 18.3 71.8 0.072 13.5 0.1 10.8 11 0 0 11 11 11 5 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EMC80126.1 - 0.0097 15.9 11.4 0.012 15.6 3.9 8.5 9 0 0 9 9 8 3 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EMC80126.1 - 0.046 13.5 0.5 0.046 13.5 0.5 10.3 11 0 0 11 11 11 0 zinc-finger C2H2-type Ribosomal_S17e PF00833.18 EMC80126.1 - 0.094 12.6 0.6 0.24 11.3 0.6 1.6 1 0 0 1 1 1 0 Ribosomal S17 Myotub-related PF06602.14 EMC80128.1 - 8.5e-150 498.5 0.1 1.2e-149 498.1 0.1 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.20 EMC80128.1 - 2.4e-19 69.3 0.0 5.6e-19 68.1 0.0 1.6 2 0 0 2 2 2 1 GRAM domain Y_phosphatase PF00102.27 EMC80128.1 - 0.00032 20.3 0.0 0.00063 19.4 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EMC80128.1 - 0.00084 19.2 0.0 0.0017 18.2 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain 3-PAP PF12578.8 EMC80128.1 - 0.0021 17.8 0.1 0.0049 16.6 0.1 1.6 1 0 0 1 1 1 1 Myotubularin-associated protein Y_phosphatase3 PF13350.6 EMC80128.1 - 0.037 14.0 0.0 0.071 13.1 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Myotub-related PF06602.14 EMC80129.1 - 3.2e-149 496.7 0.0 4e-149 496.3 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.20 EMC80129.1 - 6.1e-09 35.8 0.0 1.1e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 GRAM domain DSPc PF00782.20 EMC80129.1 - 0.00085 19.2 0.0 0.0021 17.9 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC80129.1 - 0.00095 18.8 0.0 0.0021 17.6 0.0 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EMC80129.1 - 0.0021 18.1 0.0 0.0035 17.3 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family 3-PAP PF12578.8 EMC80129.1 - 0.0045 16.7 0.4 0.013 15.2 0.1 1.9 2 0 0 2 2 2 1 Myotubularin-associated protein DUF4441 PF14536.6 EMC80129.1 - 0.14 12.3 1.2 0.33 11.1 1.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4441) Myb_CC_LHEQLE PF14379.6 EMC80129.1 - 0.46 10.2 3.7 13 5.6 1.0 2.5 2 0 0 2 2 2 0 MYB-CC type transfactor, LHEQLE motif CD99L2 PF12301.8 EMC80130.1 - 5.9e-50 169.9 1.6 7e-50 169.6 1.6 1.1 1 0 0 1 1 1 1 CD99 antigen like protein 2 HMG_box_2 PF09011.10 EMC80131.1 - 2.6e-49 165.7 10.2 5e-30 103.9 7.1 2.3 2 0 0 2 2 2 2 HMG-box domain HMG_box PF00505.19 EMC80131.1 - 3.2e-44 149.2 9.9 1e-27 96.3 0.1 2.5 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_5 PF14887.6 EMC80131.1 - 0.00055 19.9 11.4 0.11 12.5 1.2 2.4 2 0 0 2 2 2 2 HMG (high mobility group) box 5 Ribosomal_60s PF00428.19 EMC80131.1 - 0.026 15.1 18.0 0.082 13.5 18.0 1.9 1 0 0 1 1 1 0 60s Acidic ribosomal protein YABBY PF04690.13 EMC80131.1 - 1.3 9.6 8.1 0.28 11.7 1.1 2.7 1 1 2 3 3 3 0 YABBY protein 7tm_1 PF00001.21 EMC80132.1 - 6.2e-41 140.5 28.1 7.7e-41 140.2 28.1 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC80132.1 - 1.3e-09 38.1 25.8 2.1e-09 37.4 25.6 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Git3 PF11710.8 EMC80132.1 - 1.4 8.6 23.8 1.2 8.8 15.6 2.2 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 VMA21 PF09446.10 EMC80133.1 - 4.1e-09 36.4 0.4 4.7e-09 36.2 0.4 1.1 1 0 0 1 1 1 1 VMA21-like domain RVT_1 PF00078.27 EMC80134.1 - 0.0022 17.6 0.0 0.0032 17.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Cadherin PF00028.17 EMC80135.1 - 1.5e-56 188.8 0.7 1.4e-19 70.3 0.0 5.4 5 0 0 5 5 5 5 Cadherin domain Cadherin_2 PF08266.12 EMC80135.1 - 3e-34 116.7 0.0 7e-31 105.9 0.1 4.2 4 0 0 4 4 4 1 Cadherin-like Cadherin_C_2 PF16492.5 EMC80135.1 - 3.4e-20 72.6 2.3 8.5e-20 71.3 1.3 2.2 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal RET_CLD1 PF17756.1 EMC80135.1 - 4.2e-05 23.8 0.0 5.1 7.4 0.0 4.2 3 1 1 4 4 4 2 RET Cadherin like domain 1 Cadherin_3 PF16184.5 EMC80135.1 - 0.00037 20.5 0.3 1.7 8.6 0.0 4.4 5 0 0 5 5 5 1 Cadherin-like zinc-ribbons_6 PF07191.12 EMC80136.1 - 0.0018 18.2 10.0 2.2 8.3 0.7 3.8 2 1 2 4 4 4 4 zinc-ribbons SERTA PF06031.13 EMC80137.1 - 1.6e-15 56.4 0.1 2.9e-15 55.6 0.1 1.4 1 0 0 1 1 1 1 SERTA motif C2 PF00168.30 EMC80138.1 - 4.9e-20 71.8 0.1 1.1e-12 48.2 0.0 2.3 2 0 0 2 2 2 2 C2 domain UTP25 PF06862.12 EMC80139.1 - 5e-192 638.9 4.9 7e-192 638.4 4.9 1.2 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DEAD PF00270.29 EMC80139.1 - 0.0035 17.1 0.0 0.27 11.0 0.0 2.5 1 1 0 1 1 1 1 DEAD/DEAH box helicase Ribosomal_S10 PF00338.22 EMC80140.1 - 2.7e-26 91.7 0.3 3.7e-26 91.2 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e ClpS PF02617.17 EMC80141.1 - 5.6e-23 80.5 0.4 1.5e-22 79.2 0.4 1.8 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS zf-UBR PF02207.20 EMC80141.1 - 3.1e-21 75.3 7.8 3.1e-21 75.3 7.8 2.7 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) Tetraspanin PF00335.20 EMC80142.1 - 1.8e-29 103.1 3.5 2.4e-29 102.7 3.5 1.1 1 0 0 1 1 1 1 Tetraspanin family MtrD PF04207.12 EMC80142.1 - 0.14 11.8 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit D TBCC PF07986.12 EMC80143.1 - 3.6e-26 91.2 0.1 4.2e-26 91.0 0.1 1.0 1 0 0 1 1 1 1 Tubulin binding cofactor C GLTSCR1 PF15249.6 EMC80144.1 - 8.8e-32 109.6 1.4 2.7e-31 108.0 1.4 1.9 1 0 0 1 1 1 1 Conserved region of unknown function on GLTSCR protein PIP49_C PF12260.8 EMC80145.1 - 1.6e-11 44.2 0.0 2.8e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 RhoGAP PF00620.27 EMC80146.1 - 7.1e-48 162.3 0.0 1.8e-47 161.0 0.0 1.8 1 0 0 1 1 1 1 RhoGAP domain DUF1679 PF07914.11 EMC80146.1 - 0.1 11.4 0.0 0.17 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Ras PF00071.22 EMC80147.1 - 1.2e-53 181.0 0.0 1.4e-53 180.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC80147.1 - 8.7e-20 71.1 0.0 1.3e-19 70.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC80147.1 - 3.1e-08 33.3 0.0 3.9e-08 32.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family PET117 PF15786.5 EMC80147.1 - 0.00061 20.0 0.0 0.0009 19.5 0.0 1.3 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial GTP_EFTU PF00009.27 EMC80147.1 - 0.0057 16.2 0.1 0.026 14.1 0.1 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain wnt PF00110.19 EMC80148.1 - 5.9e-131 436.6 23.8 6.7e-131 436.5 23.8 1.0 1 0 0 1 1 1 1 wnt family MEF2_binding PF09047.10 EMC80148.1 - 0.2 11.5 1.0 0.51 10.2 1.0 1.6 1 0 0 1 1 1 0 MEF2 binding zf-H2C2_2 PF13465.6 EMC80149.1 - 1e-36 123.7 99.1 2e-07 31.1 0.4 14.5 14 1 0 14 14 14 11 Zinc-finger double domain zf-C2H2 PF00096.26 EMC80149.1 - 6.1e-31 105.2 99.9 1.5e-05 25.2 0.6 14.5 14 0 0 14 14 14 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC80149.1 - 8e-29 97.8 102.3 0.0083 16.9 0.2 14.7 14 0 0 14 14 14 11 C2H2-type zinc finger BTB PF00651.31 EMC80149.1 - 3.8e-19 69.0 0.2 9.7e-19 67.6 0.2 1.7 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_jaz PF12171.8 EMC80149.1 - 9.9e-07 28.9 55.1 0.73 10.2 0.7 13.4 14 0 0 14 14 14 6 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMC80149.1 - 0.0076 16.2 0.3 0.0076 16.2 0.3 13.7 14 0 0 14 14 13 7 C2H2-type zinc finger zf-H2C2_5 PF13909.6 EMC80149.1 - 0.024 14.4 0.1 0.024 14.4 0.1 7.0 8 1 0 8 8 6 0 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.5 EMC80149.1 - 0.091 12.5 0.0 0.091 12.5 0.0 9.2 10 0 0 10 10 9 0 zinc-finger C2H2-type zf-C2HC_2 PF13913.6 EMC80149.1 - 0.24 11.3 26.1 1.6 8.7 0.0 8.4 8 0 0 8 8 8 0 zinc-finger of a C2HC-type zf-met PF12874.7 EMC80149.1 - 0.47 10.9 61.5 1.1 9.8 0.1 12.0 13 0 0 13 13 13 0 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.5 EMC80149.1 - 0.51 11.1 50.7 1.2 9.9 0.5 7.0 4 2 2 6 6 6 0 zinc-ribbon family zf-C2H2_3rep PF18868.1 EMC80149.1 - 4.3 8.0 52.7 5.6 7.7 0.9 7.8 1 1 7 9 9 9 0 Zinc finger C2H2-type, 3 repeats Pkinase_Tyr PF07714.17 EMC80150.1 - 7.6e-94 313.8 0.0 1e-93 313.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.19 EMC80150.1 - 1.2e-67 227.4 0.1 1.9e-67 226.8 0.1 1.3 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.25 EMC80150.1 - 1.3e-45 155.9 0.0 1.8e-45 155.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 EMC80150.1 - 3.3e-32 110.7 0.1 2.3e-16 59.9 0.1 2.9 3 0 0 3 3 3 2 Fibronectin type III domain EphA2_TM PF14575.6 EMC80150.1 - 7.4e-21 74.8 0.0 1.6e-20 73.7 0.0 1.6 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_1 PF00536.30 EMC80150.1 - 1.6e-19 70.1 0.1 2.8e-19 69.3 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC80150.1 - 4.7e-16 58.7 0.0 1.1e-15 57.5 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pur_ac_phosph_N PF16656.5 EMC80150.1 - 5.2e-08 33.4 0.2 1.7e-06 28.5 0.3 2.6 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.5 EMC80150.1 - 5.7e-07 29.6 0.4 0.00042 20.4 0.1 2.6 2 0 0 2 2 2 2 Fibronectin type III domain SusE PF14292.6 EMC80150.1 - 7.7e-06 26.1 0.1 0.0099 16.1 0.3 2.4 2 0 0 2 2 2 2 SusE outer membrane protein Ephrin_rec_like PF07699.13 EMC80150.1 - 9.1e-05 22.2 3.4 9.1e-05 22.2 3.4 2.4 2 0 0 2 2 2 1 Putative ephrin-receptor like DUF2369 PF10179.9 EMC80150.1 - 0.00086 19.6 0.0 0.24 11.8 0.0 2.5 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2369) Kdo PF06293.14 EMC80150.1 - 0.005 16.2 0.0 0.0089 15.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Interfer-bind PF09294.10 EMC80150.1 - 0.005 17.1 0.1 0.036 14.4 0.1 2.4 3 0 0 3 3 2 1 Interferon-alpha/beta receptor, fibronectin type III Haspin_kinase PF12330.8 EMC80150.1 - 0.0094 14.9 0.0 0.016 14.2 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain DUF3300 PF11737.8 EMC80150.1 - 0.042 13.4 1.2 2.5 7.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3300) C1q PF00386.21 EMC80151.1 - 4.6e-35 120.6 0.1 5.6e-35 120.3 0.1 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 EMC80151.1 - 3e-12 46.1 31.6 2.6e-08 33.5 17.4 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) BclA_C PF18573.1 EMC80151.1 - 0.0054 16.7 0.2 0.0088 16.0 0.2 1.3 1 0 0 1 1 1 1 BclA C-terminal domain TNF PF00229.18 EMC80151.1 - 0.047 13.6 0.6 1.8 8.5 0.6 2.1 1 1 0 1 1 1 0 TNF(Tumour Necrosis Factor) family GST_N_5 PF18485.1 EMC80151.1 - 0.14 12.5 0.0 0.28 11.6 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain C1q PF00386.21 EMC80152.1 - 5.2e-37 126.9 0.2 6.6e-37 126.6 0.2 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 EMC80152.1 - 1.2e-14 53.7 44.0 1.3e-08 34.4 18.6 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) BclA_C PF18573.1 EMC80152.1 - 0.0016 18.3 0.3 0.0022 17.9 0.3 1.2 1 0 0 1 1 1 1 BclA C-terminal domain PT PF04886.12 EMC80153.1 - 0.00069 19.1 16.8 0.12 12.0 0.6 4.1 2 2 1 3 3 3 3 PT repeat Pkinase_Tyr PF07714.17 EMC80154.1 - 1.1e-95 319.8 0.0 1.6e-95 319.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.19 EMC80154.1 - 9.6e-74 247.3 0.1 1.6e-73 246.6 0.1 1.4 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.25 EMC80154.1 - 4.5e-46 157.4 0.0 7e-46 156.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 EMC80154.1 - 1.5e-37 127.8 3.2 1.4e-17 63.8 0.6 3.2 4 0 0 4 4 4 2 Fibronectin type III domain EphA2_TM PF14575.6 EMC80154.1 - 1.6e-23 83.4 0.1 3e-23 82.5 0.1 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_1 PF00536.30 EMC80154.1 - 8.2e-22 77.4 0.1 2.1e-21 76.1 0.0 1.8 2 0 0 2 2 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC80154.1 - 2.2e-19 69.3 0.0 4.4e-19 68.3 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ephrin_rec_like PF07699.13 EMC80154.1 - 1.3e-06 28.1 5.5 1.3e-06 28.1 5.5 3.0 2 1 1 3 3 3 1 Putative ephrin-receptor like Pur_ac_phosph_N PF16656.5 EMC80154.1 - 0.00023 21.7 2.6 0.0012 19.4 1.1 2.6 3 0 0 3 3 2 1 Purple acid Phosphatase, N-terminal domain SusE PF14292.6 EMC80154.1 - 0.0048 17.1 0.4 0.095 12.9 0.6 2.4 2 0 0 2 2 2 1 SusE outer membrane protein DUF4998 PF16389.5 EMC80154.1 - 0.0087 15.7 0.0 0.017 14.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function Interfer-bind PF09294.10 EMC80154.1 - 0.027 14.8 0.1 3.6 8.0 0.1 2.9 3 0 0 3 3 3 0 Interferon-alpha/beta receptor, fibronectin type III Haspin_kinase PF12330.8 EMC80154.1 - 0.078 11.9 0.0 0.15 11.0 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain cEGF PF12662.7 EMC80154.1 - 0.086 12.8 5.1 0.28 11.2 0.4 2.8 2 0 0 2 2 2 0 Complement Clr-like EGF-like Kdo PF06293.14 EMC80154.1 - 0.094 12.1 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Beta-lactamase PF00144.24 EMC80155.1 - 4.5e-37 128.0 0.0 6.9e-37 127.4 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase Guanylin PF02058.15 EMC80156.1 - 8.2e-29 99.9 1.4 9e-29 99.8 1.4 1.0 1 0 0 1 1 1 1 Guanylin precursor Enterotoxin_ST PF02048.16 EMC80156.1 - 0.034 14.6 5.6 0.074 13.5 5.6 1.6 1 0 0 1 1 1 0 Heat-stable enterotoxin ST ADP_ribosyl_GH PF03747.14 EMC80157.1 - 3.1e-45 155.1 5.9 3.7e-45 154.9 5.9 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Leu_zip PF15294.6 EMC80158.1 - 1.8e-123 411.5 28.4 2e-123 411.3 28.4 1.0 1 0 0 1 1 1 1 Leucine zipper Filament PF00038.21 EMC80158.1 - 0.0022 17.6 7.2 0.0022 17.6 7.2 2.3 1 1 1 2 2 2 2 Intermediate filament protein MAD PF05557.13 EMC80158.1 - 0.021 13.2 26.4 0.03 12.7 26.4 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein HisKA_3 PF07730.13 EMC80158.1 - 0.5 10.9 5.0 2.3 8.8 0.3 2.9 2 1 0 2 2 2 0 Histidine kinase ArsC PF03960.15 EMC80158.1 - 3 7.9 6.4 5.7 7.0 0.1 3.0 2 2 0 2 2 2 0 ArsC family TRAF_BIRC3_bd PF16673.5 EMC80158.1 - 8 6.3 13.7 5.3 6.9 3.9 3.8 3 1 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain SNF PF00209.18 EMC80159.1 - 4.8e-63 213.6 4.6 5.4e-63 213.5 4.6 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family EamA PF00892.20 EMC80159.1 - 0.067 13.4 8.1 1 9.5 2.5 2.3 2 0 0 2 2 2 0 EamA-like transporter family LSM PF01423.22 EMC80160.1 - 3.8e-19 68.1 0.7 5.8e-19 67.6 0.7 1.3 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EMC80160.1 - 0.01 15.5 0.0 0.016 14.9 0.0 1.3 1 0 0 1 1 1 0 Hfq protein Gemin7 PF11095.8 EMC80160.1 - 0.025 14.4 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) SM-ATX PF14438.6 EMC80160.1 - 0.047 13.8 0.1 0.069 13.3 0.1 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain API5 PF05918.11 EMC80160.1 - 1.6 7.4 3.3 2.2 7.0 3.3 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Syja_N PF02383.18 EMC80161.1 - 2.1e-16 60.2 0.0 3.1e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain Syja_N PF02383.18 EMC80162.1 - 6.2e-18 65.2 0.2 7.9e-18 64.8 0.2 1.0 1 0 0 1 1 1 1 SacI homology domain Adeno_GP19K PF04881.13 EMC80162.1 - 0.032 14.2 0.0 0.045 13.7 0.0 1.2 1 0 0 1 1 1 0 Adenovirus GP19K LIM PF00412.22 EMC80163.1 - 6e-31 106.5 34.2 9.2e-12 45.0 5.5 3.3 3 0 0 3 3 3 3 LIM domain SUIM_assoc PF16619.5 EMC80163.1 - 0.1 12.7 2.3 0.36 10.9 2.3 1.9 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 tRNA-synt_1 PF00133.22 EMC80165.1 - 7.6e-48 163.2 3.4 8.7e-24 83.7 6.6 6.1 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EMC80165.1 - 7.9e-32 110.5 0.0 2.4e-20 72.7 0.0 3.6 3 0 0 3 3 3 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EMC80165.1 - 2.4e-11 43.8 0.3 5.7e-11 42.6 0.3 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1_2 PF13603.6 EMC80165.1 - 8.1e-10 38.5 0.0 1.4e-07 31.2 0.0 2.5 1 1 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EMC80165.1 - 0.00067 19.1 0.0 0.23 10.8 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EMC80165.1 - 0.012 14.6 0.0 0.49 9.3 0.0 2.5 3 0 0 3 3 3 0 tRNA synthetases class I (K) fn3 PF00041.21 EMC80166.1 - 0.038 14.3 0.5 0.29 11.5 0.5 1.9 1 1 0 1 1 1 0 Fibronectin type III domain DUF4680 PF15730.5 EMC80166.1 - 0.21 11.9 0.1 0.25 11.7 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4680) Ribosomal_S9 PF00380.19 EMC80167.1 - 9.8e-33 113.3 0.2 1.1e-32 113.1 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Ank_4 PF13637.6 EMC80168.1 - 4.7e-29 100.4 0.4 5.7e-12 45.9 0.0 4.4 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC80168.1 - 2.5e-27 95.3 0.4 4.5e-13 49.6 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC80168.1 - 1.2e-23 82.8 3.2 3.4e-07 30.4 0.0 4.6 2 2 2 4 4 4 4 Ankyrin repeats (many copies) PRKG1_interact PF15898.5 EMC80168.1 - 1.9e-22 80.1 3.5 1.9e-22 80.1 3.5 6.3 7 2 0 7 7 7 1 cGMP-dependent protein kinase interacting domain Ank PF00023.30 EMC80168.1 - 5.3e-20 70.9 0.3 0.0031 17.9 0.0 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EMC80168.1 - 3.2e-16 57.8 1.7 0.017 15.6 0.0 4.8 4 0 0 4 4 4 4 Ankyrin repeat Yae1_N PF09811.9 EMC80170.1 - 2.8e-15 55.7 55.1 1.8e+04 -20.3 55.1 5.2 1 1 0 1 1 1 0 Essential protein Yae1, N terminal Ion_trans PF00520.31 EMC80171.1 - 5.5e-23 81.5 15.3 8.2e-23 80.9 15.3 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_N PF08412.10 EMC80171.1 - 1.9e-20 72.2 0.1 3.8e-20 71.2 0.1 1.6 1 0 0 1 1 1 1 Ion transport protein N-terminal cNMP_binding PF00027.29 EMC80171.1 - 1.5e-18 66.6 0.0 3e-18 65.7 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 EMC80171.1 - 0.0032 17.4 0.2 0.0086 16.0 0.2 1.7 1 0 0 1 1 1 1 Ion channel Neogenin_C PF06583.12 EMC80172.1 - 2e-126 421.8 21.1 4.1e-126 420.7 21.1 1.6 1 0 0 1 1 1 1 Neogenin C-terminus fn3 PF00041.21 EMC80172.1 - 3.8e-83 273.9 27.2 3.5e-18 65.7 0.0 6.4 6 0 0 6 6 6 6 Fibronectin type III domain I-set PF07679.16 EMC80172.1 - 2.7e-55 184.4 0.0 2.9e-16 59.3 0.0 6.6 7 0 0 7 7 7 4 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC80172.1 - 5e-47 158.4 0.2 5e-12 46.3 0.0 7.1 6 0 0 6 6 6 4 Immunoglobulin domain Ig_2 PF13895.6 EMC80172.1 - 4.1e-34 116.7 0.0 2.9e-07 30.7 0.0 4.9 5 0 0 5 5 4 4 Immunoglobulin domain ig PF00047.25 EMC80172.1 - 1.1e-24 86.4 0.0 6.1e-06 26.3 0.0 5.9 6 0 0 6 6 5 4 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 EMC80172.1 - 4.1e-22 78.6 21.5 0.00039 20.9 2.9 7.6 6 2 0 6 6 6 5 Purple acid Phosphatase, N-terminal domain V-set PF07686.17 EMC80172.1 - 8.4e-15 54.9 7.6 0.00083 19.5 0.0 9.1 5 4 1 6 6 6 1 Immunoglobulin V-set domain Interfer-bind PF09294.10 EMC80172.1 - 7.1e-13 48.8 0.0 0.064 13.6 0.0 5.9 6 0 0 6 6 6 2 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.9 EMC80172.1 - 1.8e-08 34.6 0.8 4.4 7.8 0.0 6.0 6 0 0 6 6 6 1 Uncharacterised conserved protein (DUF2369) C2-set_2 PF08205.12 EMC80172.1 - 2.4e-08 33.9 0.0 0.04 14.0 0.0 4.1 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Tissue_fac PF01108.17 EMC80172.1 - 2.1e-06 27.5 1.9 0.026 14.4 0.0 4.9 4 1 1 5 5 5 1 Tissue factor Ig_5 PF16681.5 EMC80172.1 - 5.9e-06 26.6 0.0 0.53 10.7 0.1 4.5 4 1 0 4 4 4 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain fn3_4 PF16794.5 EMC80172.1 - 6.7e-06 26.0 0.6 6.4 6.8 0.0 5.6 5 1 0 5 5 5 1 Fibronectin-III type domain Ig_4 PF16680.5 EMC80172.1 - 0.0002 21.5 0.1 2.8 8.3 0.0 4.5 4 1 0 4 4 4 1 T-cell surface glycoprotein CD3 delta chain SusE PF14292.6 EMC80172.1 - 0.00092 19.4 0.2 0.22 11.7 0.0 3.9 4 0 0 4 4 4 1 SusE outer membrane protein TMEM154 PF15102.6 EMC80172.1 - 0.0011 18.9 0.4 0.0035 17.2 0.0 2.0 2 0 0 2 2 2 1 TMEM154 protein family EphA2_TM PF14575.6 EMC80172.1 - 0.002 18.9 0.3 0.0046 17.8 0.3 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Izumo-Ig PF16706.5 EMC80172.1 - 0.0059 16.6 0.0 1.1 9.4 0.0 4.0 4 1 0 4 4 4 1 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 EMC80172.1 - 0.019 14.6 0.0 4.5 6.9 0.0 3.6 4 0 0 4 4 4 0 Immunoglobulin domain DUF4959 PF16323.5 EMC80172.1 - 0.025 14.9 6.7 1.3 9.3 0.0 3.7 4 1 0 4 4 3 0 Domain of unknown function (DUF4959) Ly49 PF08391.10 EMC80172.1 - 0.038 14.3 0.0 0.074 13.4 0.0 1.4 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Herpes_UL74 PF07982.12 EMC80172.1 - 0.047 12.6 2.7 0.082 11.8 2.7 1.3 1 0 0 1 1 1 0 Herpes UL74 glycoproteins Shisa PF13908.6 EMC80172.1 - 0.084 13.1 0.4 0.3 11.3 0.0 2.2 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator F5_F8_type_C PF00754.25 EMC80172.1 - 0.21 11.7 3.3 1.9 8.6 0.1 3.5 4 0 0 4 4 3 0 F5/8 type C domain Insulin_TMD PF17870.1 EMC80172.1 - 1.1 9.4 4.3 2.8 8.1 4.3 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment ADP_PFK_GK PF04587.15 EMC80173.1 - 2.5e-133 444.8 0.0 2.8e-133 444.6 0.0 1.0 1 0 0 1 1 1 1 ADP-specific Phosphofructokinase/Glucokinase conserved region TPR_2 PF07719.17 EMC80174.1 - 6.9e-41 135.1 19.7 3.6e-06 26.7 0.3 10.6 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_1 PF00515.28 EMC80174.1 - 4.1e-39 130.8 19.4 7.1e-06 25.6 0.3 8.9 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_8 PF13181.6 EMC80174.1 - 6.6e-34 113.3 20.4 1e-05 25.3 0.0 9.1 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_11 PF13414.6 EMC80174.1 - 2.2e-26 91.2 13.3 1.1e-07 31.4 0.0 8.0 3 2 6 9 9 9 5 TPR repeat TPR_19 PF14559.6 EMC80174.1 - 1.4e-25 89.6 6.2 5.8e-06 26.7 0.1 7.1 4 2 3 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.6 EMC80174.1 - 4.5e-23 81.6 0.0 0.00049 20.7 0.0 6.4 3 1 2 6 6 6 5 Tetratricopeptide repeat TPR_12 PF13424.6 EMC80174.1 - 1.5e-21 76.4 14.8 3.2e-06 27.3 0.2 7.5 5 2 2 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 EMC80174.1 - 2.8e-18 65.0 1.2 0.0026 18.4 0.0 7.5 2 2 6 8 8 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 EMC80174.1 - 4.6e-18 64.2 15.9 0.00024 21.3 0.0 8.9 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_9 PF13371.6 EMC80174.1 - 3.2e-16 59.2 0.0 0.00014 21.9 0.0 5.3 2 1 4 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC80174.1 - 2.2e-14 53.4 26.5 8.5e-06 25.9 1.7 6.1 1 1 6 7 7 7 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EMC80174.1 - 4.9e-14 51.2 9.1 0.0037 17.2 0.0 8.2 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 EMC80174.1 - 2.3e-10 40.4 12.8 0.55 11.0 0.0 9.7 10 0 0 10 10 10 1 Tetratricopeptide repeat PknG_TPR PF16918.5 EMC80174.1 - 1.8e-09 36.8 1.1 0.0064 15.3 0.0 3.1 2 1 1 3 3 3 3 Protein kinase G tetratricopeptide repeat TPR_15 PF13429.6 EMC80174.1 - 7.8e-09 35.1 5.9 2.4e-05 23.7 0.3 3.8 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_20 PF14561.6 EMC80174.1 - 8e-07 29.3 3.7 0.012 15.9 0.0 4.5 4 1 0 4 4 4 2 Tetratricopeptide repeat NARP1 PF12569.8 EMC80174.1 - 1e-05 24.7 5.2 0.013 14.5 0.1 3.8 2 2 1 3 3 3 1 NMDA receptor-regulated protein 1 Wzy_C_2 PF11846.8 EMC80174.1 - 1.9e-05 24.7 2.9 0.57 10.1 0.0 4.4 2 2 2 4 4 4 1 Virulence factor membrane-bound polymerase, C-terminal ChAPs PF09295.10 EMC80174.1 - 5.4e-05 22.4 0.8 0.0029 16.7 0.1 2.6 2 0 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_10 PF13374.6 EMC80174.1 - 0.00016 21.4 16.4 2.8 7.9 0.2 7.4 8 0 0 8 8 7 1 Tetratricopeptide repeat Coatomer_E PF04733.14 EMC80174.1 - 0.0011 18.4 5.9 0.61 9.4 0.7 3.4 2 1 1 3 3 3 1 Coatomer epsilon subunit ComR_TPR PF18710.1 EMC80174.1 - 0.0027 17.3 3.4 0.36 10.4 0.2 3.0 2 1 1 3 3 3 1 ComR tetratricopeptide DUF627 PF04781.12 EMC80174.1 - 0.0079 16.2 5.9 17 5.5 0.0 5.1 3 1 2 5 5 5 0 Protein of unknown function (DUF627) TPR_MalT PF17874.1 EMC80174.1 - 0.014 14.8 3.9 1.8 7.9 0.0 3.7 2 1 1 3 3 3 0 MalT-like TPR region HrpB1_HrpK PF09613.10 EMC80174.1 - 0.021 14.5 0.0 6.1 6.5 0.1 2.6 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) DUF4810 PF16068.5 EMC80174.1 - 0.032 14.8 1.9 14 6.3 0.0 4.2 3 1 2 5 5 3 0 Domain of unknown function (DUF4810) Mu-like_Pro PF10123.9 EMC80174.1 - 0.093 12.3 1.2 0.43 10.1 0.6 2.3 2 1 0 2 2 2 0 Mu-like prophage I protein TPR_21 PF09976.9 EMC80174.1 - 0.094 12.4 6.1 1 9.0 0.2 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat-like domain BTAD PF03704.17 EMC80174.1 - 0.11 12.9 4.7 15 6.0 0.1 4.4 2 1 2 4 4 4 0 Bacterial transcriptional activator domain Csm1_B PF18211.1 EMC80174.1 - 0.19 11.6 1.5 4 7.4 0.1 3.1 2 1 1 3 3 3 0 Csm1 subunit domain B Clathrin PF00637.20 EMC80174.1 - 0.48 10.3 7.8 2.9 7.8 0.2 3.2 2 1 1 3 3 3 0 Region in Clathrin and VPS Fis1_TPR_C PF14853.6 EMC80174.1 - 1.2 9.3 7.9 4.9 7.3 0.1 4.4 4 1 1 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat IBR PF01485.21 EMC80175.1 - 2.6e-18 66.0 44.3 3.4e-14 52.8 10.1 5.1 4 1 1 5 5 5 3 IBR domain, a half RING-finger domain zf-C3HC4_2 PF13923.6 EMC80175.1 - 4.6e-06 26.4 2.6 4.6e-06 26.4 2.6 4.4 3 1 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC80175.1 - 0.00037 20.3 3.8 0.00037 20.3 3.8 4.5 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC80175.1 - 0.00037 20.4 6.1 0.00037 20.4 6.1 3.9 3 1 0 3 3 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EMC80175.1 - 0.0011 18.9 4.2 0.0011 18.9 4.2 4.8 4 1 0 4 4 4 1 RING-type zinc-finger zf-RING_14 PF17978.1 EMC80175.1 - 0.0013 19.1 1.9 0.0013 19.1 1.9 2.4 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-RING_2 PF13639.6 EMC80175.1 - 0.0014 18.9 6.1 0.0014 18.9 6.1 4.4 3 2 0 3 3 3 1 Ring finger domain zf-C3HC4_4 PF15227.6 EMC80175.1 - 0.002 18.2 5.1 0.002 18.2 5.1 4.6 4 1 1 5 5 5 2 zinc finger of C3HC4-type, RING OmpH PF03938.14 EMC80175.1 - 0.22 11.8 5.4 0.12 12.7 1.7 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Med14 PF08638.11 EMC80175.1 - 0.62 9.5 4.4 0.14 11.6 0.4 2.0 3 0 0 3 3 3 0 Mediator complex subunit MED14 Glyco_hydro_20 PF00728.22 EMC80176.1 - 5.5e-76 256.2 0.0 1e-75 255.4 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EMC80176.1 - 3.5e-10 40.7 0.0 5.8e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EMC80176.1 - 4.5e-05 24.2 0.0 7.5e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 RRM_1 PF00076.22 EMC80177.1 - 2.3e-43 145.8 0.1 6.2e-18 64.4 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMC80177.1 - 1.6e-05 24.9 0.1 0.5 10.5 0.0 3.7 3 1 0 3 3 3 3 RNA recognition motif RNA_bind PF08675.11 EMC80177.1 - 0.0008 19.4 0.0 3.2 7.8 0.0 3.6 3 0 0 3 3 3 2 RNA binding domain PK PF00224.21 EMC80178.1 - 2.8e-166 552.6 4.0 3.5e-166 552.3 4.0 1.0 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain HpcH_HpaI PF03328.14 EMC80178.1 - 0.00024 20.3 0.2 0.00059 19.0 0.3 1.7 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family TRAPPC9-Trs120 PF08626.11 EMC80179.1 - 4.7e-44 150.2 0.1 3e-20 71.3 0.0 4.5 2 2 1 3 3 3 3 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Vps23_core PF09454.10 EMC80179.1 - 0.037 14.0 0.0 0.094 12.7 0.0 1.7 1 0 0 1 1 1 0 Vps23 core domain PMBR PF09373.10 EMC80179.1 - 0.19 12.0 0.3 0.65 10.3 0.1 2.1 2 0 0 2 2 2 0 Pseudomurein-binding repeat TPR_1 PF00515.28 EMC80179.1 - 0.27 11.1 0.6 18 5.4 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat SeqA PF03925.13 EMC80180.1 - 0.017 15.1 0.2 5.1 7.1 0.0 2.4 1 1 1 2 2 2 0 SeqA protein C-terminal domain FERM_M PF00373.18 EMC80180.1 - 0.03 14.7 0.6 4.8 7.6 0.0 2.2 1 1 1 2 2 2 0 FERM central domain Pkinase_Tyr PF07714.17 EMC80181.1 - 2.5e-93 312.1 0.0 3.8e-93 311.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Focal_AT PF03623.13 EMC80181.1 - 8.8e-56 187.6 3.3 1.8e-55 186.5 3.3 1.5 1 0 0 1 1 1 1 Focal adhesion targeting region Pkinase PF00069.25 EMC80181.1 - 6.2e-46 156.9 0.0 1.5e-45 155.7 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain FERM_N_2 PF18038.1 EMC80181.1 - 5.4e-44 149.0 0.2 1.9e-43 147.2 0.2 2.0 1 0 0 1 1 1 1 FERM N-terminal domain FERM_M PF00373.18 EMC80181.1 - 1.8e-05 25.1 1.4 5.3e-05 23.6 0.0 2.4 3 0 0 3 3 3 1 FERM central domain Haspin_kinase PF12330.8 EMC80181.1 - 0.0013 17.7 0.0 0.0025 16.8 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EMC80181.1 - 0.0081 15.5 0.0 0.016 14.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like C1-set PF07654.15 EMC80182.1 - 0.0028 18.0 0.0 0.017 15.5 0.0 2.1 2 1 0 2 2 2 1 Immunoglobulin C1-set domain DUF2117 PF09890.9 EMC80182.1 - 0.086 12.3 0.0 0.095 12.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2117) V-set PF07686.17 EMC80183.1 - 1.1e-08 35.3 0.0 1.3e-08 35.0 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC80183.1 - 0.064 13.9 0.0 0.14 12.7 0.0 1.6 1 1 0 1 1 1 0 Immunoglobulin domain Glyco_transf_29 PF00777.18 EMC80185.1 - 2.7e-67 227.0 0.0 3.2e-67 226.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) 7tm_4 PF13853.6 EMC80186.1 - 1.9e-50 172.2 23.6 2.3e-50 171.9 23.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC80186.1 - 6e-23 81.5 24.5 9.5e-23 80.9 24.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Saf_2TM PF18303.1 EMC80186.1 - 3.4 7.2 5.5 12 5.4 0.4 2.5 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain zf-C2H2 PF00096.26 EMC80187.1 - 0.0053 17.1 0.6 0.0053 17.1 0.6 6.1 6 0 0 6 6 6 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC80187.1 - 0.013 16.3 32.7 0.025 15.4 0.2 6.7 5 1 0 5 5 5 0 C2H2-type zinc finger Evr1_Alr PF04777.13 EMC80188.1 - 2e-31 108.4 2.4 2.3e-31 108.2 2.4 1.0 1 0 0 1 1 1 1 Erv1 / Alr family SH3_9 PF14604.6 EMC80189.1 - 1.4e-15 56.9 0.1 1.6e-11 43.9 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 EMC80189.1 - 1.2e-13 50.4 0.8 9e-09 34.8 0.0 2.4 2 0 0 2 2 2 2 SH3 domain PX PF00787.24 EMC80189.1 - 2.2e-09 37.3 1.9 1.8e-08 34.3 1.7 2.2 2 0 0 2 2 2 1 PX domain SH3_2 PF07653.17 EMC80189.1 - 2.6e-09 36.6 0.1 6.2e-05 22.6 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_3 PF08239.11 EMC80189.1 - 3.2e-06 27.3 0.9 0.017 15.4 0.1 2.6 2 0 0 2 2 2 2 Bacterial SH3 domain p47_phox_C PF08944.11 EMC80189.1 - 7.8e-05 22.0 0.7 0.00016 21.0 0.7 1.5 1 0 0 1 1 1 1 NADPH oxidase subunit p47Phox, C terminal domain SH3_4 PF06347.13 EMC80189.1 - 0.0052 16.6 1.1 0.024 14.5 0.0 2.4 3 0 0 3 3 3 1 Bacterial SH3 domain WD40 PF00400.32 EMC80190.1 - 2e-55 183.5 34.5 3.6e-07 30.8 0.4 11.7 11 0 0 11 11 11 9 WD domain, G-beta repeat Utp13 PF08625.11 EMC80190.1 - 2.3e-41 141.0 1.5 3.9e-41 140.3 1.5 1.4 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 EMC80190.1 - 4.2e-10 39.8 8.0 0.59 10.5 0.0 8.2 3 3 5 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMC80190.1 - 2.7e-07 29.6 8.0 0.23 10.0 0.0 5.8 4 2 1 5 5 5 4 Nucleoporin Nup120/160 NUP214 PF16755.5 EMC80190.1 - 0.00014 21.2 0.1 0.00067 19.0 0.0 2.1 2 0 0 2 2 2 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 WD40_like PF17005.5 EMC80190.1 - 0.0013 18.1 0.1 9.9 5.4 0.0 4.6 3 2 0 5 5 5 1 WD40-like domain UTP15_C PF09384.10 EMC80190.1 - 0.0036 17.0 1.6 0.0067 16.1 1.6 1.4 1 0 0 1 1 1 1 UTP15 C terminal Nucleoporin_N PF08801.11 EMC80190.1 - 0.0075 15.1 5.0 3.8 6.2 0.1 5.0 3 3 2 5 5 5 1 Nup133 N terminal like LRRC37AB_C PF14914.6 EMC80190.1 - 0.018 14.9 1.0 0.032 14.1 1.0 1.4 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain Ge1_WD40 PF16529.5 EMC80190.1 - 0.019 13.9 8.4 1.4 7.8 0.4 5.3 2 2 3 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Mcl1_mid PF12341.8 EMC80190.1 - 0.027 13.9 0.0 0.49 9.7 0.0 2.7 1 1 0 2 2 2 0 Minichromosome loss protein, Mcl1, middle region CP12 PF02672.15 EMC80190.1 - 0.67 10.8 2.9 7.6 7.4 0.9 2.8 2 0 0 2 2 2 0 CP12 domain NDUFB10 PF10249.9 EMC80191.1 - 1.7e-48 164.3 8.6 1.8e-48 164.2 8.6 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 WW PF00397.26 EMC80191.1 - 0.091 12.9 0.9 0.17 12.0 0.9 1.5 1 0 0 1 1 1 0 WW domain Ribosomal_L3 PF00297.22 EMC80192.1 - 2.5e-180 599.3 12.8 2.9e-180 599.1 12.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 MMM1 PF10296.9 EMC80193.1 - 4.1e-09 35.9 0.2 3.5e-07 29.6 0.0 2.2 2 0 0 2 2 2 2 Maintenance of mitochondrial morphology protein 1 SelR PF01641.18 EMC80195.1 - 3.6e-18 65.8 0.2 4.3e-18 65.6 0.2 1.0 1 0 0 1 1 1 1 SelR domain Zn_ribbon_recom PF13408.6 EMC80195.1 - 0.0013 19.2 0.4 0.67 10.5 0.0 2.2 2 0 0 2 2 2 2 Recombinase zinc beta ribbon domain zinc_ribbon_2 PF13240.6 EMC80195.1 - 0.013 15.2 2.6 0.61 9.9 0.0 2.3 2 0 0 2 2 2 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 EMC80195.1 - 0.028 13.9 0.1 3.4 7.3 0.0 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding zinc_ribbon_4 PF13717.6 EMC80195.1 - 0.048 13.6 3.6 0.4 10.7 0.4 2.2 2 0 0 2 2 2 0 zinc-ribbon domain TFIIS_C PF01096.18 EMC80195.1 - 0.049 13.5 0.8 2.1 8.3 0.1 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zf_UBZ PF18439.1 EMC80195.1 - 0.053 13.1 1.3 0.29 10.8 0.1 2.1 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DUF983 PF06170.12 EMC80195.1 - 0.055 13.9 0.3 5.1 7.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF983) Zn_ribbon_SprT PF17283.2 EMC80195.1 - 0.069 13.1 0.5 5.5 7.0 0.1 2.2 2 0 0 2 2 2 0 SprT-like zinc ribbon domain zf-ribbon_3 PF13248.6 EMC80195.1 - 0.13 11.7 3.5 2.1 7.9 0.2 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 EMC80195.1 - 0.14 12.3 1.3 2.2 8.4 0.2 2.2 2 0 0 2 2 2 0 Zinc ribbon domain DUF1451 PF07295.11 EMC80195.1 - 0.17 11.9 0.6 1.7 8.6 0.1 2.0 1 1 1 2 2 2 0 Zinc-ribbon containing domain zinc_ribbon_5 PF13719.6 EMC80195.1 - 0.2 11.5 4.6 3.4 7.5 0.8 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-NADH-PPase PF09297.11 EMC80195.1 - 0.46 10.2 3.9 2.5 7.8 0.1 2.3 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain zf-Mss51 PF13824.6 EMC80195.1 - 0.5 10.5 2.3 4.1 7.6 0.2 2.1 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 DAGK_acc PF00609.19 EMC80196.1 - 1.1e-55 188.3 0.0 2.7e-55 187.1 0.0 1.7 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 EMC80196.1 - 1.2e-27 96.1 0.0 2.2e-27 95.1 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 EMC80196.1 - 3.3e-21 74.9 34.5 1.5e-12 47.2 7.0 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_1 PF00036.32 EMC80196.1 - 1.1e-12 46.5 0.4 3.9e-05 22.9 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EMC80196.1 - 3.5e-09 35.9 0.0 8.6e-05 22.2 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EMC80196.1 - 9.7e-09 34.3 0.1 0.0038 16.6 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EMC80196.1 - 1.7e-08 34.8 0.1 4.3e-08 33.5 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 EMC80196.1 - 0.00032 20.5 0.6 0.93 9.4 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EMC80196.1 - 0.0059 16.9 0.1 0.069 13.5 0.1 2.7 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region DUF1033 PF06279.11 EMC80196.1 - 0.11 12.7 1.4 0.29 11.3 1.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1033) C1_2 PF03107.16 EMC80196.1 - 0.18 12.2 20.7 0.26 11.6 4.7 2.6 2 0 0 2 2 2 0 C1 domain ETS_PEA3_N PF04621.13 EMC80197.1 - 4.1e-145 484.0 20.5 5.5e-145 483.6 20.5 1.2 1 0 0 1 1 1 1 PEA3 subfamily ETS-domain transcription factor N terminal domain Ets PF00178.22 EMC80197.1 - 2.1e-38 130.6 0.2 3.5e-38 129.9 0.2 1.4 1 0 0 1 1 1 1 Ets-domain Arf PF00025.21 EMC80198.1 - 7.6e-67 224.1 0.0 8.8e-67 223.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EMC80198.1 - 1.6e-17 63.6 0.0 1.7e-17 63.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC80198.1 - 3.9e-17 62.6 0.1 5.2e-17 62.2 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EMC80198.1 - 2.1e-12 46.8 0.1 2.1e-12 46.8 0.1 1.4 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EMC80198.1 - 1.1e-08 34.7 0.6 1.4e-06 27.8 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 EMC80198.1 - 3.4e-08 33.6 0.1 4.7e-08 33.1 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMC80198.1 - 5e-05 22.8 0.0 7e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EMC80198.1 - 5.3e-05 22.9 0.1 0.00026 20.6 0.1 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 EMC80198.1 - 0.0046 16.8 0.0 0.018 14.8 0.0 1.7 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein 6PF2K PF01591.18 EMC80198.1 - 0.02 14.2 0.0 0.033 13.5 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_28 PF13521.6 EMC80198.1 - 0.061 13.6 0.0 0.44 10.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EMC80198.1 - 0.11 12.3 0.7 0.23 11.4 0.6 1.6 1 1 1 2 2 2 0 NTPase Gelsolin PF00626.22 EMC80199.1 - 6.7e-18 64.4 0.3 3.7e-10 39.6 0.0 2.4 3 0 0 3 3 3 2 Gelsolin repeat Gelsolin PF00626.22 EMC80200.1 - 5.3e-12 45.5 0.0 2.5e-05 24.1 0.0 2.1 2 0 0 2 2 2 2 Gelsolin repeat EGF_2 PF07974.13 EMC80201.1 - 4.6e-24 84.5 194.2 0.00012 22.3 10.2 13.7 11 2 2 13 13 13 11 EGF-like domain VWD PF00094.25 EMC80201.1 - 1.6e-12 48.0 1.5 4.3e-11 43.3 0.2 2.7 2 1 0 2 2 2 1 von Willebrand factor type D domain EGF PF00008.27 EMC80201.1 - 2.9e-10 40.2 189.2 0.0038 17.5 4.9 14.1 14 0 0 14 14 14 9 EGF-like domain hEGF PF12661.7 EMC80201.1 - 1e-07 32.3 175.6 0.012 16.2 4.1 15.0 15 0 0 15 15 15 11 Human growth factor-like EGF DUF1356 PF07092.12 EMC80202.1 - 1.8e-117 390.6 5.7 2.1e-117 390.4 5.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1356) Anti-TRAP PF15777.5 EMC80202.1 - 0.03 14.3 0.1 0.054 13.5 0.1 1.3 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein DnaJ_CXXCXGXG PF00684.19 EMC80202.1 - 0.042 14.2 0.3 0.14 12.5 0.1 2.0 2 0 0 2 2 2 0 DnaJ central domain LEA_2 PF03168.13 EMC80202.1 - 0.11 13.0 0.7 0.49 10.9 0.9 2.0 1 1 1 2 2 2 0 Late embryogenesis abundant protein TSP_1 PF00090.19 EMC80203.1 - 1.8e-66 220.1 221.5 4.4e-13 49.2 1.9 23.9 25 1 0 25 25 25 18 Thrombospondin type 1 domain I-set PF07679.16 EMC80204.1 - 7.9e-201 650.9 13.9 3.3e-27 94.4 0.1 10.0 10 0 0 10 10 10 9 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC80204.1 - 7.9e-123 401.3 16.2 3.3e-14 53.3 0.0 10.5 10 0 0 10 10 10 9 Immunoglobulin domain ig PF00047.25 EMC80204.1 - 5.6e-85 279.6 15.6 2.2e-09 37.3 0.0 9.6 9 0 0 9 9 9 9 Immunoglobulin domain Ig_2 PF13895.6 EMC80204.1 - 1e-79 262.9 16.0 3.1e-10 40.2 0.1 9.8 10 0 0 10 10 9 9 Immunoglobulin domain Pkinase PF00069.25 EMC80204.1 - 5.5e-77 258.7 0.0 1.1e-76 257.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain 23ISL PF16620.5 EMC80204.1 - 2.5e-47 161.1 17.1 2.5e-47 161.1 17.1 3.5 4 0 0 4 4 2 1 Unstructured linker between I-set domains 2 and 3 on MYLCK V-set PF07686.17 EMC80204.1 - 5.3e-41 139.2 17.7 0.00019 21.6 0.3 15.6 11 5 0 11 11 11 8 Immunoglobulin V-set domain Pkinase_Tyr PF07714.17 EMC80204.1 - 1.7e-35 122.5 0.0 3.1e-35 121.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase C2-set_2 PF08205.12 EMC80204.1 - 1e-26 92.8 2.8 0.013 15.5 0.0 8.9 8 0 0 8 8 8 7 CD80-like C2-set immunoglobulin domain fn3 PF00041.21 EMC80204.1 - 1.5e-16 60.5 0.4 5.1e-16 58.8 0.4 2.0 1 0 0 1 1 1 1 Fibronectin type III domain Ig_6 PF18452.1 EMC80204.1 - 3.6e-10 39.2 0.2 0.81 9.3 0.0 7.0 7 0 0 7 7 7 2 Immunoglobulin domain BiPBP_C PF06832.12 EMC80204.1 - 3.6e-10 39.7 0.0 11 6.2 0.0 8.2 7 0 0 7 7 7 0 Penicillin-Binding Protein C-terminus Family Receptor_2B4 PF11465.8 EMC80204.1 - 2.7e-09 37.2 2.1 0.6 10.3 0.0 7.9 9 0 0 9 9 9 2 Natural killer cell receptor 2B4 Ig_C17orf99 PF17736.1 EMC80204.1 - 4.8e-09 36.1 0.2 1.4 9.0 0.0 7.5 10 0 0 10 10 7 1 C17orf99 Ig domain Herpes_gE PF02480.16 EMC80204.1 - 2.3e-07 30.0 0.0 0.012 14.4 0.0 5.3 6 0 0 6 6 6 1 Alphaherpesvirus glycoprotein E Ig_4 PF16680.5 EMC80204.1 - 2.9e-07 30.6 12.8 1.3 9.3 0.0 8.9 9 1 0 9 9 9 3 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 EMC80204.1 - 0.00029 20.8 17.0 1.3 9.2 0.0 8.3 10 0 0 10 10 9 2 Izumo-like Immunoglobulin domain Kinase-like PF14531.6 EMC80204.1 - 0.00048 19.5 0.0 0.0014 18.0 0.0 1.8 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC80204.1 - 0.022 14.1 0.1 0.053 12.9 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EMC80204.1 - 0.034 13.7 0.1 0.091 12.4 0.1 1.7 1 0 0 1 1 1 0 RIO1 family V-set_CD47 PF08204.11 EMC80204.1 - 0.052 13.5 8.1 9.9 6.2 0.0 5.9 7 0 0 7 7 7 0 CD47 immunoglobulin-like domain PTPLA PF04387.14 EMC80205.1 - 1.7e-60 203.5 12.5 2.4e-60 203.0 12.5 1.2 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA AC_N PF16214.5 EMC80206.1 - 3.3e-162 540.4 2.3 4.1e-162 540.1 2.3 1.0 1 0 0 1 1 1 1 Adenylyl cyclase N-terminal extracellular and transmembrane region Lectin_N PF03954.14 EMC80206.1 - 0.035 13.8 2.8 0.77 9.5 0.2 2.6 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain 7TMR-DISM_7TM PF07695.11 EMC80206.1 - 1.1 9.1 16.1 0.83 9.5 13.7 1.7 1 1 1 2 2 2 0 7TM diverse intracellular signalling DUF2781 PF10914.8 EMC80206.1 - 1.5 9.3 12.7 0.28 11.6 7.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2781) Guanylate_cyc PF00211.20 EMC80207.1 - 2.5e-58 196.7 0.1 3.3e-58 196.3 0.1 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.5 EMC80207.1 - 9.9e-57 192.9 3.6 1.3e-56 192.6 3.6 1.1 1 0 0 1 1 1 1 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF1053 PF06327.14 EMC80207.1 - 0.0058 17.2 0.4 0.017 15.7 0.0 2.0 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1053) TBK1_ULD PF18396.1 EMC80207.1 - 0.0063 16.4 0.1 0.013 15.4 0.1 1.5 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain HNOBA PF07701.14 EMC80207.1 - 0.05 13.0 0.1 0.11 12.0 0.1 1.5 1 0 0 1 1 1 0 Heme NO binding associated GBR2_CC PF18455.1 EMC80207.1 - 0.055 13.6 0.1 0.16 12.1 0.0 1.8 2 0 0 2 2 2 0 Gamma-aminobutyric acid type B receptor subunit 2 coiled-coil domain Longin PF13774.6 EMC80208.1 - 5.3e-20 71.2 0.2 1.1e-19 70.3 0.2 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain Sema PF01403.19 EMC80209.1 - 1.1e-132 442.8 0.6 2.5e-132 441.7 0.0 1.8 2 0 0 2 2 2 1 Sema domain TSP_1 PF00090.19 EMC80209.1 - 2.9e-44 149.0 98.1 1.4e-10 41.2 9.0 7.7 7 0 0 7 7 7 6 Thrombospondin type 1 domain 7TM_GPCR_Srz PF10325.9 EMC80209.1 - 0.075 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srz MFS_1 PF07690.16 EMC80211.1 - 4.6e-06 25.8 27.4 4.6e-06 25.8 27.4 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily AceK PF06315.11 EMC80211.1 - 0.068 11.6 0.0 0.091 11.2 0.0 1.1 1 0 0 1 1 1 0 Isocitrate dehydrogenase kinase/phosphatase (AceK) Cupin_8 PF13621.6 EMC80212.1 - 1.5e-35 123.2 0.0 2.4e-35 122.5 0.0 1.4 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 EMC80212.1 - 7.9e-09 35.4 0.0 1.3e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 EMC80212.1 - 0.002 18.5 0.0 0.0043 17.5 0.0 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase EAF PF09816.9 EMC80213.1 - 4.1e-13 49.6 0.1 1.5e-12 47.8 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase II transcription elongation factor AF-4 PF05110.13 EMC80213.1 - 0.0014 16.9 24.5 0.0018 16.5 24.5 1.3 1 0 0 1 1 1 1 AF-4 proto-oncoprotein PAN_3 PF08277.12 EMC80213.1 - 0.024 14.4 0.1 0.062 13.1 0.1 1.7 1 0 0 1 1 1 0 PAN-like domain Lin-8 PF03353.15 EMC80213.1 - 0.93 9.0 11.4 1.1 8.8 11.4 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Cwf_Cwc_15 PF04889.12 EMC80213.1 - 1.1 9.0 11.5 1.9 8.2 11.5 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Macoilin PF09726.9 EMC80213.1 - 1.1 7.8 13.5 1.2 7.6 13.5 1.0 1 0 0 1 1 1 0 Macoilin family SR-25 PF10500.9 EMC80213.1 - 2.1 7.9 24.8 3.6 7.1 24.8 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IQ PF00612.27 EMC80214.1 - 8.8e-14 49.9 18.8 1.1e-06 27.9 0.8 5.1 4 0 0 4 4 4 3 IQ calmodulin-binding motif RNA_pol_Rpb1_7 PF04990.12 EMC80214.1 - 0.055 13.5 0.1 0.2 11.7 0.1 1.9 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 7 RNase_HII PF01351.18 EMC80214.1 - 0.13 12.0 0.2 0.36 10.6 0.2 1.7 1 0 0 1 1 1 0 Ribonuclease HII RhoGEF PF00621.20 EMC80216.1 - 1.4e-37 129.7 3.5 2.4e-37 128.9 3.2 1.6 2 0 0 2 2 2 1 RhoGEF domain PH_13 PF16652.5 EMC80216.1 - 0.0091 15.8 0.0 0.022 14.6 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain Sda PF08970.10 EMC80216.1 - 0.08 12.7 1.5 0.19 11.5 1.5 1.7 1 0 0 1 1 1 0 Sporulation inhibitor A IDEAL PF08858.10 EMC80216.1 - 0.11 12.2 1.5 0.3 10.8 1.5 1.8 1 0 0 1 1 1 0 IDEAL domain MKRN1_C PF15815.5 EMC80216.1 - 0.19 12.1 2.4 1.9 9.0 0.3 2.8 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase makorin-1, C-terminal hNIFK_binding PF12196.8 EMC80217.1 - 9e-19 66.7 0.4 1.6e-18 65.9 0.4 1.4 1 0 0 1 1 1 1 FHA Ki67 binding domain of hNIFK RRM_1 PF00076.22 EMC80217.1 - 2.9e-07 30.2 0.0 5.9e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CLASP_N PF12348.8 EMC80218.1 - 7.2e-56 189.3 14.4 3.6e-37 128.1 0.5 4.9 4 1 0 4 4 4 3 CLASP N terminal HEAT PF02985.22 EMC80218.1 - 5e-19 66.8 8.6 1.2e-05 25.1 0.0 9.7 9 0 0 9 9 9 3 HEAT repeat HEAT_EZ PF13513.6 EMC80218.1 - 4.7e-12 46.1 1.7 0.016 15.7 0.1 6.0 6 0 0 6 6 5 3 HEAT-like repeat HEAT_2 PF13646.6 EMC80218.1 - 1.2e-10 41.7 3.9 0.1 13.0 0.0 7.8 5 2 4 10 10 10 4 HEAT repeats Sec7_N PF12783.7 EMC80218.1 - 1.4e-07 31.5 7.1 0.017 15.0 0.0 5.3 5 0 0 5 5 5 2 Guanine nucleotide exchange factor in Golgi transport N-terminal Vac14_Fab1_bd PF12755.7 EMC80218.1 - 2.4e-07 31.3 1.7 1.9 9.2 0.0 6.0 6 0 0 6 6 6 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EMC80218.1 - 2.4e-07 30.9 11.3 0.0046 17.0 0.9 6.4 6 1 1 7 7 7 2 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 EMC80218.1 - 5.2e-06 26.6 9.5 0.061 13.5 0.1 5.6 6 2 1 7 7 5 2 Required for nuclear transport of RNA pol II C-terminus 1 Adaptin_N PF01602.20 EMC80218.1 - 9.5e-06 24.4 8.2 1.2 7.6 0.0 5.9 5 2 0 7 7 7 3 Adaptin N terminal region Tti2 PF10521.9 EMC80218.1 - 0.00012 21.7 4.6 2.4 7.6 0.0 5.4 4 1 0 5 5 5 2 Tti2 family ParcG PF10274.9 EMC80218.1 - 0.00023 21.4 0.5 0.0075 16.4 0.1 3.1 1 1 1 2 2 2 1 Parkin co-regulated protein TFCD_C PF12612.8 EMC80218.1 - 0.0013 18.6 1.6 0.026 14.4 0.2 3.5 3 1 0 3 3 3 1 Tubulin folding cofactor D C terminal MMS19_C PF12460.8 EMC80218.1 - 0.0025 17.0 1.5 1.6 7.8 0.1 3.3 3 0 0 3 3 3 2 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 EMC80218.1 - 0.003 17.2 6.1 0.61 9.6 0.2 4.6 3 2 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II Dopey_N PF04118.14 EMC80218.1 - 0.0046 16.1 3.4 0.36 9.9 0.1 3.5 4 0 0 4 4 4 1 Dopey, N-terminal TAN PF11640.8 EMC80218.1 - 0.0078 16.4 1.3 0.22 11.7 0.1 3.8 3 0 0 3 3 3 1 Telomere-length maintenance and DNA damage repair XRN_M PF17846.1 EMC80218.1 - 0.017 14.1 0.0 0.032 13.2 0.0 1.4 1 0 0 1 1 1 0 Xrn1 helical domain HMW1C_N PF18071.1 EMC80218.1 - 0.069 13.0 0.0 2.2 8.1 0.0 2.5 2 0 0 2 2 2 0 HMW1C N-terminal RasGEF_N_2 PF14663.6 EMC80218.1 - 0.084 13.3 0.2 8.2 6.9 0.1 3.8 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain TPR_20 PF14561.6 EMC80218.1 - 0.1 12.9 3.1 0.35 11.2 0.4 3.3 2 1 1 3 3 2 0 Tetratricopeptide repeat Ipi1_N PF12333.8 EMC80218.1 - 0.23 12.1 3.7 3.1 8.5 0.2 4.4 3 1 0 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation Nipped-B_C PF12830.7 EMC80218.1 - 9.9 6.1 7.7 30 4.5 0.0 4.3 5 1 1 6 6 6 0 Sister chromatid cohesion C-terminus CP2 PF04516.15 EMC80219.1 - 7.6e-57 192.2 0.0 1.1e-56 191.7 0.0 1.1 1 0 0 1 1 1 1 CP2 transcription factor SAM_3 PF18016.1 EMC80219.1 - 2.4e-17 62.5 0.0 4.4e-17 61.6 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 EMC80219.1 - 0.022 14.7 0.0 0.046 13.7 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain TGF_beta PF00019.20 EMC80220.1 - 6.1e-30 104.3 0.2 7.3e-30 104.0 0.2 1.1 1 0 0 1 1 1 1 Transforming growth factor beta like domain TctA PF01970.16 EMC80220.1 - 0.021 13.5 0.1 0.027 13.2 0.1 1.1 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctA family DUF411 PF04214.13 EMC80220.1 - 0.046 13.6 0.0 0.082 12.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF IN_DBD_C PF00552.21 EMC80221.1 - 1.8e-09 36.7 0.7 3e-09 36.0 0.7 1.3 1 0 0 1 1 1 1 Integrase DNA binding domain Ras PF00071.22 EMC80222.1 - 1e-54 184.5 0.1 1.2e-54 184.3 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC80222.1 - 4.6e-21 75.3 0.0 7.7e-21 74.5 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC80222.1 - 5.6e-10 38.9 0.0 6.9e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EMC80222.1 - 2.6e-09 37.2 0.2 1.6e-05 24.9 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 EMC80222.1 - 1.9e-05 24.2 0.1 2.9e-05 23.6 0.1 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EMC80222.1 - 7.5e-05 22.4 0.1 0.00028 20.5 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EMC80222.1 - 0.00058 19.9 0.0 0.0011 19.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMC80222.1 - 0.001 18.5 0.0 0.0013 18.1 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_25 PF13481.6 EMC80222.1 - 0.003 17.2 0.0 0.0072 15.9 0.0 1.6 1 1 0 1 1 1 1 AAA domain Septin PF00735.18 EMC80222.1 - 0.0095 15.2 0.0 1.2 8.3 0.0 2.2 2 0 0 2 2 2 2 Septin FeoB_N PF02421.18 EMC80222.1 - 0.039 13.5 0.0 0.44 10.1 0.0 2.0 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_24 PF13479.6 EMC80222.1 - 0.055 13.2 1.6 1.1 8.9 1.6 2.4 1 1 0 1 1 1 0 AAA domain FERM_C PF09380.10 EMC80224.1 - 1.1e-21 77.0 0.0 2e-21 76.2 0.0 1.4 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 EMC80224.1 - 2.7e-19 69.7 0.3 6e-19 68.6 0.1 1.7 2 0 0 2 2 2 1 FERM central domain FA PF08736.11 EMC80224.1 - 2.5e-14 53.1 12.0 6.2e-14 51.8 12.0 1.7 1 0 0 1 1 1 1 FERM adjacent (FA) FERM_N PF09379.10 EMC80224.1 - 6e-14 51.7 0.2 2.5e-13 49.7 0.1 2.1 2 0 0 2 2 2 1 FERM N-terminal domain ACBP PF00887.19 EMC80224.1 - 0.0027 17.9 0.0 0.0066 16.6 0.0 1.6 1 0 0 1 1 1 1 Acyl CoA binding protein FERM_C PF09380.10 EMC80225.1 - 3.1e-27 94.8 0.3 6.8e-27 93.7 0.3 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 EMC80225.1 - 8.4e-25 87.5 2.2 1e-24 87.2 0.4 2.0 3 0 0 3 3 3 1 FERM central domain FERM_N PF09379.10 EMC80225.1 - 1.4e-19 69.7 0.1 1.5e-18 66.5 0.1 2.3 2 0 0 2 2 2 1 FERM N-terminal domain FA PF08736.11 EMC80225.1 - 1.5e-14 53.7 3.1 1.7e-14 53.6 0.6 2.3 2 0 0 2 2 2 1 FERM adjacent (FA) Ras PF00071.22 EMC80227.1 - 2.7e-53 179.9 0.0 3.2e-53 179.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC80227.1 - 3e-20 72.6 0.0 4.8e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EMC80227.1 - 4.1e-07 29.7 0.1 1e-06 28.5 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Arf PF00025.21 EMC80227.1 - 2.2e-06 27.2 0.0 2.9e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EMC80227.1 - 3.2e-05 23.9 0.6 0.028 14.3 0.0 2.2 1 1 1 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EMC80227.1 - 0.0024 18.0 0.0 0.0043 17.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EMC80227.1 - 0.0048 16.7 0.1 0.029 14.1 0.0 1.9 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 EMC80227.1 - 0.072 13.5 0.1 0.12 12.7 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain MMR_HSR1_Xtn PF16897.5 EMC80227.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.4 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Gtr1_RagA PF04670.12 EMC80227.1 - 0.12 11.7 0.1 0.14 11.4 0.1 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region LCM PF04072.14 EMC80231.1 - 7.2e-24 84.8 0.0 1.1e-23 84.1 0.0 1.2 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Kelch_5 PF13854.6 EMC80231.1 - 2e-12 46.8 1.6 0.83 9.7 0.1 6.5 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 EMC80231.1 - 3.8e-10 39.6 2.3 1.1 9.3 0.1 6.3 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EMC80231.1 - 3.1e-07 30.4 4.1 0.037 14.3 0.1 4.7 3 1 2 5 5 5 2 Kelch motif Kelch_2 PF07646.15 EMC80231.1 - 0.0002 21.2 6.7 0.098 12.7 0.1 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 EMC80231.1 - 0.026 14.1 0.1 0.026 14.1 0.1 3.7 5 0 0 5 5 5 0 Kelch motif Kelch_3 PF13415.6 EMC80231.1 - 0.53 10.6 0.1 0.53 10.6 0.1 5.1 5 1 0 5 5 5 0 Galactose oxidase, central domain MRP-S33 PF08293.11 EMC80232.1 - 3.9e-26 91.1 3.9 4.9e-26 90.8 3.9 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Pkinase_Tyr PF07714.17 EMC80233.1 - 1.5e-63 214.5 0.0 2.2e-63 214.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC80233.1 - 1e-58 198.8 0.0 1.4e-58 198.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RBD PF02196.15 EMC80233.1 - 1.5e-26 92.2 0.0 3.6e-26 91.0 0.0 1.7 1 0 0 1 1 1 1 Raf-like Ras-binding domain C1_1 PF00130.22 EMC80233.1 - 3.3e-12 46.1 7.1 6.4e-12 45.2 7.1 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.6 EMC80233.1 - 1.1e-08 34.7 0.0 1.7e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like zf-RING-like PF08746.11 EMC80233.1 - 7.7e-05 22.9 2.7 0.00021 21.6 2.7 1.7 1 0 0 1 1 1 1 RING-like domain C1_2 PF03107.16 EMC80233.1 - 0.0032 17.8 3.6 0.007 16.7 3.6 1.6 1 0 0 1 1 1 1 C1 domain Pkinase_fungal PF17667.1 EMC80233.1 - 0.0042 15.9 0.0 0.0071 15.2 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMC80233.1 - 0.052 13.5 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EMC80233.1 - 0.11 11.9 0.1 0.18 11.2 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DENN PF02141.21 EMC80234.1 - 4.7e-57 192.9 1.1 1e-56 191.9 1.1 1.6 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 EMC80234.1 - 4.7e-16 59.3 0.2 1e-15 58.2 0.2 1.6 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 EMC80234.1 - 9e-12 44.8 0.7 2.7e-11 43.3 0.7 1.8 1 0 0 1 1 1 1 dDENN domain SPA PF08616.10 EMC80234.1 - 0.19 11.7 0.1 0.41 10.6 0.1 1.4 1 0 0 1 1 1 0 Stabilization of polarity axis MKRN1_C PF15815.5 EMC80235.1 - 8.5e-41 138.2 1.8 2.3e-40 136.9 1.8 1.7 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase makorin-1, C-terminal zf-CCCH_4 PF18044.1 EMC80235.1 - 1.2e-27 95.2 40.4 8.8e-08 31.8 8.1 4.7 4 0 0 4 4 4 4 CCCH-type zinc finger Torus PF16131.5 EMC80235.1 - 3.5e-17 63.1 15.1 4.8e-06 27.2 1.5 4.4 3 1 1 4 4 4 4 Torus domain zf-CCCH PF00642.24 EMC80235.1 - 5.8e-15 54.8 35.6 1.5e-05 24.8 0.1 4.5 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EMC80235.1 - 6.5e-14 51.4 41.7 2.3e-05 24.3 2.4 5.0 4 1 0 4 4 4 3 Zinc finger domain zf-C3HC4 PF00097.25 EMC80235.1 - 6.8e-07 29.1 7.1 6.8e-07 29.1 7.1 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC80235.1 - 9e-06 25.6 3.0 2.6e-05 24.1 3.0 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMC80235.1 - 3.6e-05 23.6 6.1 3.6e-05 23.6 6.1 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-CCCH_3 PF15663.5 EMC80235.1 - 6.1e-05 23.2 3.9 6.1e-05 23.2 3.9 3.1 3 1 0 3 3 3 1 Zinc-finger containing family zf-RING_2 PF13639.6 EMC80235.1 - 6.1e-05 23.3 6.2 6.1e-05 23.3 6.2 3.0 3 1 1 4 4 2 1 Ring finger domain zf-CCCH_2 PF14608.6 EMC80235.1 - 0.00023 21.5 30.9 0.95 10.0 1.3 4.9 4 1 0 4 4 4 4 RNA-binding, Nab2-type zinc finger zf-rbx1 PF12678.7 EMC80235.1 - 0.001 19.3 5.0 0.001 19.3 5.0 3.1 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EMC80235.1 - 0.0011 19.0 3.6 0.0011 19.0 3.6 3.1 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 EMC80235.1 - 0.0036 17.4 4.0 0.0036 17.4 4.0 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 EMC80235.1 - 0.47 10.2 8.0 0.056 13.2 2.4 2.5 2 0 0 2 2 2 0 RING-like zinc finger zf-C3HC4_2 PF13923.6 EMC80235.1 - 0.66 9.9 15.8 0.55 10.1 10.1 3.7 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) MFS_1 PF07690.16 EMC80236.1 - 6.8e-40 137.1 27.7 1.6e-36 126.0 14.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMC80236.1 - 0.00012 21.1 31.8 0.0074 15.2 10.0 3.3 2 2 0 2 2 2 2 Sugar (and other) transporter JHD PF17811.1 EMC80237.1 - 4.3e-43 146.1 0.1 1.3e-42 144.5 0.1 1.9 1 0 0 1 1 1 1 Jumonji helical domain JmjC PF02373.22 EMC80237.1 - 2e-10 41.1 5.8 5.6e-10 39.7 2.1 3.1 2 1 0 2 2 2 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 EMC80237.1 - 2.4e-08 34.0 0.3 2.4e-08 34.0 0.3 3.0 2 2 0 2 2 2 1 Cupin-like domain AA_permease_2 PF13520.6 EMC80238.1 - 2e-51 175.2 38.5 2.3e-51 175.0 38.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMC80238.1 - 1.8e-22 79.6 38.7 1e-21 77.1 38.7 1.9 1 1 0 1 1 1 1 Amino acid permease DUF4491 PF14898.6 EMC80238.1 - 0.28 11.6 4.4 1.9 9.0 0.3 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4491) PARP PF00644.20 EMC80240.1 - 5.4e-41 140.3 0.2 1.7e-40 138.7 0.2 1.7 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Aldo_ket_red PF00248.21 EMC80241.1 - 9.8e-46 156.3 0.0 1.2e-45 156.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Bromodomain PF00439.25 EMC80242.1 - 9.5e-23 80.1 0.2 2.4e-22 78.8 0.2 1.7 1 0 0 1 1 1 1 Bromodomain zf-B_box PF00643.24 EMC80242.1 - 3.1e-11 43.2 24.0 1.9e-09 37.5 7.7 4.8 5 0 0 5 5 5 2 B-box zinc finger PHD PF00628.29 EMC80242.1 - 1.3e-08 34.6 10.0 1.3e-08 34.6 10.0 4.5 4 1 0 4 4 4 1 PHD-finger zf-Sec23_Sec24 PF04810.15 EMC80242.1 - 1.1 9.4 5.4 4.2 7.5 2.4 3.2 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger MFS_1 PF07690.16 EMC80243.1 - 6.9e-30 104.2 43.1 5.3e-22 78.2 22.4 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMC80243.1 - 3.8e-22 78.8 33.9 4.7e-19 68.6 11.5 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter V_ATPase_I PF01496.19 EMC80244.1 - 0 1107.1 6.9 0 1107.0 6.9 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family KASH_CCD PF14662.6 EMC80244.1 - 2.1 8.1 7.1 2.6 7.8 2.0 2.1 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH TMEM213 PF15192.6 EMC80245.1 - 2.4e-29 101.1 1.9 2.5e-29 101.0 1.9 1.0 1 0 0 1 1 1 1 TMEM213 family p450 PF00067.22 EMC80246.1 - 2.4e-100 336.5 1.1 1.3e-69 235.2 0.2 3.0 3 0 0 3 3 3 3 Cytochrome P450 MCM_bind PF09739.9 EMC80246.1 - 0.15 10.5 0.0 0.22 9.9 0.0 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor PARP PF00644.20 EMC80247.1 - 1.6e-38 132.3 2.7 6.7e-38 130.2 2.7 2.0 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.20 EMC80247.1 - 1.2e-15 57.8 3.1 7.3e-15 55.3 1.6 2.7 2 0 0 2 2 2 1 WWE domain zf-CCCH_4 PF18044.1 EMC80247.1 - 5.7e-06 26.0 2.3 5.7e-06 26.0 2.3 3.2 3 0 0 3 3 3 1 CCCH-type zinc finger zf-CCCH PF00642.24 EMC80247.1 - 1.6e-05 24.7 2.4 1.6e-05 24.7 2.4 3.3 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EMC80247.1 - 0.00056 19.9 4.4 0.00056 19.9 4.4 3.7 4 0 0 4 4 4 1 Zinc finger domain HTH_Tnp_4 PF13613.6 EMC80247.1 - 0.092 12.5 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease Ets PF00178.22 EMC80249.1 - 4.7e-23 81.4 0.4 8.5e-23 80.6 0.4 1.4 1 0 0 1 1 1 1 Ets-domain I-set PF07679.16 EMC80250.1 - 2.5e-96 315.9 2.4 3.9e-20 71.7 0.0 7.6 7 0 0 7 7 7 7 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC80250.1 - 3.4e-62 207.0 0.3 2.2e-14 53.8 0.1 7.6 7 0 0 7 7 7 7 Immunoglobulin domain fn3 PF00041.21 EMC80250.1 - 1.6e-44 150.1 1.2 3.7e-14 52.8 0.0 5.2 5 0 0 5 5 5 3 Fibronectin type III domain Ig_2 PF13895.6 EMC80250.1 - 1e-41 141.1 0.6 1.1e-09 38.4 0.1 7.6 7 1 0 7 7 7 7 Immunoglobulin domain ig PF00047.25 EMC80250.1 - 5e-37 126.0 1.2 1.5e-09 37.9 0.0 7.7 8 0 0 8 8 8 6 Immunoglobulin domain THB PF18362.1 EMC80250.1 - 2.2e-21 75.1 0.4 9.1e-21 73.2 0.0 2.1 2 0 0 2 2 2 1 Tri-helix bundle domain V-set PF07686.17 EMC80250.1 - 3.7e-16 59.2 7.6 0.034 14.3 0.1 9.7 7 3 0 7 7 7 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC80250.1 - 1.2e-10 41.3 0.2 0.041 14.0 0.0 5.9 6 0 0 6 6 6 3 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 EMC80250.1 - 3.1e-07 30.7 3.4 2.2 8.8 0.0 6.6 7 0 0 7 7 7 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C1-set PF07654.15 EMC80250.1 - 9.3e-07 29.1 4.0 5.1 7.5 0.0 6.1 6 0 0 6 6 6 2 Immunoglobulin C1-set domain Pur_ac_phosph_N PF16656.5 EMC80250.1 - 0.00011 22.7 3.5 1.1 9.8 0.1 5.0 5 1 1 6 6 4 1 Purple acid Phosphatase, N-terminal domain DUF4251 PF14059.6 EMC80250.1 - 0.0028 17.6 1.2 6.3 6.7 0.1 3.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4251) Izumo-Ig PF16706.5 EMC80250.1 - 0.034 14.2 0.7 18 5.4 0.0 4.1 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 EMC80250.1 - 0.047 14.0 11.8 1 9.7 0.0 5.7 6 2 0 6 6 6 0 T-cell surface glycoprotein CD3 delta chain LIFR_D2 PF17971.1 EMC80250.1 - 0.062 13.5 0.1 0.66 10.2 0.0 2.7 3 0 0 3 3 2 0 Leukemia inhibitory factor receptor D2 domain V-set_CD47 PF08204.11 EMC80250.1 - 0.097 12.7 0.3 13 5.8 0.1 3.2 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain CDP-OH_P_transf PF01066.21 EMC80251.1 - 1.7e-11 44.7 0.0 1.7e-11 44.7 0.0 3.4 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Cor1 PF04803.12 EMC80252.1 - 5.3e-60 201.4 31.5 9.8e-60 200.5 31.5 1.5 1 0 0 1 1 1 1 Cor1/Xlr/Xmr conserved region Peptidase_C65 PF10275.9 EMC80252.1 - 0.021 14.3 11.2 0.022 14.2 10.5 1.3 1 1 0 1 1 1 0 Peptidase C65 Otubain T3SSipB PF16535.5 EMC80252.1 - 0.19 12.2 16.9 0.53 10.8 16.8 1.9 1 1 0 1 1 1 0 Type III cell invasion protein SipB Focal_AT PF03623.13 EMC80252.1 - 0.35 10.8 11.3 5.3 7.0 6.0 2.2 2 0 0 2 2 2 0 Focal adhesion targeting region Vac_Fusion PF02346.16 EMC80252.1 - 3.5 7.3 9.1 0.84 9.3 3.0 3.1 2 1 1 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 Stealth_CR2 PF11380.8 EMC80253.1 - 7e-46 154.9 2.4 2.3e-45 153.2 0.4 2.8 2 0 0 2 2 2 1 Stealth protein CR2, conserved region 2 GlcNAc-1_reg PF18440.1 EMC80253.1 - 7.7e-45 151.1 0.1 2.8e-44 149.3 0.1 2.1 1 0 0 1 1 1 1 Putative GlcNAc-1 phosphotransferase regulatory domain Stealth_CR4 PF17103.5 EMC80253.1 - 3.8e-24 84.3 3.0 9.3e-24 83.1 1.7 2.3 2 0 0 2 2 2 1 Stealth protein CR4, conserved region 4 Stealth_CR3 PF17102.5 EMC80253.1 - 6.5e-19 67.6 7.0 1.9e-18 66.1 7.0 1.9 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 Notch PF00066.17 EMC80253.1 - 1.7e-15 57.2 31.9 5.3e-09 36.4 12.6 2.4 2 0 0 2 2 2 2 LNR domain Stealth_CR1 PF17101.5 EMC80253.1 - 8.5e-12 44.6 0.0 1.9e-11 43.4 0.0 1.7 1 0 0 1 1 1 1 Stealth protein CR1, conserved region 1 DMAP_binding PF06464.11 EMC80253.1 - 2.3e-10 41.2 0.2 7.9e-10 39.5 0.2 2.0 1 0 0 1 1 1 1 DMAP1-binding Domain EF-hand_1 PF00036.32 EMC80253.1 - 0.031 13.8 0.0 0.09 12.4 0.0 1.9 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 EMC80253.1 - 0.085 13.3 0.1 1.4 9.4 0.0 2.7 2 0 0 2 2 2 0 EF-hand domain pair CCDC53 PF10152.9 EMC80255.1 - 6.2e-49 166.3 0.3 7.5e-49 166.1 0.3 1.1 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex WD40 PF00400.32 EMC80256.1 - 1.2e-14 54.4 1.9 2.4e-05 25.0 0.2 4.7 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC80256.1 - 0.0011 19.2 0.0 0.025 14.9 0.0 2.9 1 1 2 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Pro-MCH PF05824.12 EMC80258.1 - 4.3e-45 151.6 0.0 6.6e-45 151.0 0.0 1.3 1 0 0 1 1 1 1 Pro-melanin-concentrating hormone (Pro-MCH) RVT_1 PF00078.27 EMC80259.1 - 0.005 16.4 0.0 0.0083 15.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Insulin PF00049.18 EMC80260.1 - 4.8e-14 53.1 8.5 5.4e-12 46.5 5.9 2.7 2 1 0 2 2 2 1 Insulin/IGF/Relaxin family Biopterin_H PF00351.21 EMC80261.1 - 4.9e-174 578.0 1.3 6e-174 577.8 1.3 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase Spc7 PF08317.11 EMC80261.1 - 0.085 11.7 1.1 0.28 10.0 0.1 2.2 3 0 0 3 3 3 0 Spc7 kinetochore protein S_4TM PF18159.1 EMC80261.1 - 0.085 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 SMODS-associating 4TM effector domain Biopterin_H PF00351.21 EMC80262.1 - 3e-176 585.3 0.1 4e-176 584.9 0.1 1.2 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.25 EMC80262.1 - 5.5e-10 38.8 0.0 1.3e-09 37.7 0.0 1.6 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 EMC80262.1 - 0.00018 22.0 0.1 0.0013 19.3 0.0 2.1 2 0 0 2 2 2 1 ACT domain 5_nucleotid PF05761.14 EMC80263.1 - 4.1e-155 517.2 6.5 4.7e-155 517.0 6.5 1.0 1 0 0 1 1 1 1 5' nucleotidase family HAD_2 PF13419.6 EMC80263.1 - 1.2e-05 25.5 0.2 0.00048 20.3 0.0 3.1 3 1 0 3 3 3 1 Haloacid dehalogenase-like hydrolase Mu-transpos_C PF09299.11 EMC80263.1 - 0.047 13.6 0.6 0.79 9.7 0.1 3.1 3 0 0 3 3 3 0 Mu transposase, C-terminal Hydrolase PF00702.26 EMC80263.1 - 0.099 12.9 0.0 0.23 11.7 0.0 1.5 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase HSP90 PF00183.18 EMC80264.1 - 5.1e-229 761.4 28.9 8.6e-229 760.7 28.9 1.3 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EMC80264.1 - 4.5e-15 56.1 0.4 8.7e-15 55.2 0.4 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EMC80264.1 - 4.4e-12 46.0 0.4 1.4e-11 44.4 0.4 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4518 PF15008.6 EMC80264.1 - 0.084 12.0 3.4 0.82 8.8 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) AbiJ_NTD5 PF18865.1 EMC80264.1 - 0.09 12.6 1.2 0.21 11.4 0.2 2.2 2 0 0 2 2 2 0 AbiJ N-terminal domain 5 MH1 PF03165.16 EMC80264.1 - 0.14 12.3 0.6 1.2 9.4 0.0 2.8 2 0 0 2 2 2 0 MH1 domain DUF4516 PF14990.6 EMC80265.1 - 8.4e-11 41.4 0.2 1e-10 41.2 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4516) UDG PF03167.19 EMC80266.1 - 2e-18 66.9 0.0 2.9e-18 66.3 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily UCH PF00443.29 EMC80267.1 - 7.4e-43 146.9 2.5 8.8e-43 146.6 2.5 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMC80267.1 - 1.1e-27 97.4 10.2 2.2e-27 96.5 10.2 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Tubulin PF00091.25 EMC80268.1 - 2e-67 227.2 0.0 2.9e-67 226.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EMC80268.1 - 2.1e-51 173.4 0.0 3.4e-51 172.6 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EMC80268.1 - 0.0031 17.2 0.0 0.008 15.9 0.0 1.7 2 0 0 2 2 2 1 Tubulin domain Tubulin PF00091.25 EMC80269.1 - 3.2e-67 226.6 0.0 4.6e-67 226.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EMC80269.1 - 1.1e-50 171.0 0.0 2e-50 170.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EMC80269.1 - 0.00068 19.4 0.0 0.0021 17.8 0.0 1.8 2 0 0 2 2 2 1 Tubulin domain Pex26 PF07163.12 EMC80270.1 - 7.2e-89 298.1 3.5 8.2e-89 297.9 3.5 1.0 1 0 0 1 1 1 1 Pex26 protein CH PF00307.31 EMC80271.1 - 9e-20 70.9 0.0 2.8e-19 69.3 0.0 1.8 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EMC80271.1 - 1.5e-12 47.2 0.0 4.7e-12 45.6 0.0 1.9 1 0 0 1 1 1 1 CAMSAP CH domain LIM PF00412.22 EMC80271.1 - 8.8e-09 35.5 10.1 1.7e-08 34.6 10.1 1.5 1 0 0 1 1 1 1 LIM domain FAD_binding_3 PF01494.19 EMC80271.1 - 1.2e-05 24.8 0.0 2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EMC80271.1 - 4.3e-05 22.9 0.0 0.0001 21.7 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMC80271.1 - 0.00019 20.8 0.0 0.00035 19.9 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMC80271.1 - 0.00068 18.4 0.0 0.0012 17.6 0.0 1.4 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 EMC80271.1 - 0.0012 18.0 0.0 0.0023 17.1 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain NAD_binding_7 PF13241.6 EMC80271.1 - 0.003 18.0 0.0 0.011 16.2 0.0 1.9 2 0 0 2 2 1 1 Putative NAD(P)-binding NAD_binding_8 PF13450.6 EMC80271.1 - 0.0041 17.3 0.0 0.012 15.9 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EMC80271.1 - 0.0052 17.3 0.0 0.02 15.4 0.0 2.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMC80271.1 - 0.007 16.0 0.0 0.013 15.1 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EMC80271.1 - 0.026 13.7 0.0 0.049 12.9 0.0 1.3 1 0 0 1 1 1 0 Thi4 family AlaDh_PNT_C PF01262.21 EMC80271.1 - 0.057 12.7 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 EMC80271.1 - 0.087 11.9 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein BID PF06393.11 EMC80272.1 - 9.8e-56 188.3 0.5 1.1e-55 188.2 0.5 1.0 1 0 0 1 1 1 1 BH3 interacting domain (BID) Bcl-2 PF00452.19 EMC80272.1 - 0.0014 19.3 0.0 0.0021 18.7 0.0 1.2 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family CRM1_C PF08767.11 EMC80272.1 - 0.032 13.4 0.6 0.05 12.8 0.6 1.4 1 1 0 1 1 1 0 CRM1 C terminal RhoGAP PF00620.27 EMC80272.1 - 0.05 13.4 0.0 0.061 13.2 0.0 1.1 1 0 0 1 1 1 0 RhoGAP domain LisH_TPL PF17814.1 EMC80272.1 - 0.31 10.7 2.6 1.8 8.3 0.4 2.5 2 0 0 2 2 2 0 LisH-like dimerisation domain Bcl-2 PF00452.19 EMC80273.1 - 1.2e-11 45.1 0.0 2e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family T3SS_needle_E PF08988.10 EMC80273.1 - 0.0061 16.7 0.6 0.0061 16.7 0.6 2.4 2 1 1 3 3 3 1 Type III secretion system, cytoplasmic E component of needle DUF4549 PF15082.6 EMC80273.1 - 0.064 13.0 2.0 0.19 11.5 2.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4549) DUF842 PF05811.13 EMC80273.1 - 0.07 12.8 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) vATP-synt_E PF01991.18 EMC80274.1 - 1.5e-76 256.3 11.6 1.7e-76 256.1 11.6 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit DUF4288 PF14119.6 EMC80274.1 - 0.014 15.8 2.6 0.022 15.2 1.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4288) Par3_HAL_N_term PF12053.8 EMC80274.1 - 0.016 15.4 2.5 1.1 9.5 0.1 2.8 2 1 1 3 3 3 0 N-terminal of Par3 and HAL proteins ATP-synt_B PF00430.18 EMC80274.1 - 0.056 13.5 15.5 0.13 12.3 0.6 2.4 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) NifW PF03206.14 EMC80274.1 - 0.2 12.2 3.6 0.28 11.7 2.5 1.8 1 1 0 1 1 1 0 Nitrogen fixation protein NifW A_deaminase PF00962.22 EMC80275.1 - 3.1e-20 72.8 0.0 4.7e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase A_deaminase_N PF08451.11 EMC80275.1 - 2.8e-16 59.6 0.0 7.4e-16 58.2 0.0 1.7 2 0 0 2 2 2 1 Adenosine/AMP deaminase N-terminal Hydrolase_like PF13242.6 EMC80276.1 - 1.7e-08 34.4 0.0 4.3e-06 26.7 0.0 2.5 2 0 0 2 2 2 2 HAD-hyrolase-like Pap_E4 PF02711.14 EMC80276.1 - 0.088 13.8 0.2 0.22 12.5 0.2 1.6 1 0 0 1 1 1 0 E4 protein VGCC_alpha2 PF08473.11 EMC80278.1 - 1.1e-42 146.4 0.0 2.6e-42 145.1 0.0 1.5 1 1 0 1 1 1 1 Neuronal voltage-dependent calcium channel alpha 2acd VWA_N PF08399.11 EMC80278.1 - 5.1e-37 127.1 0.1 9.6e-37 126.2 0.1 1.5 1 0 0 1 1 1 1 VWA N-terminal VWA_3 PF13768.6 EMC80278.1 - 3.8e-16 59.4 0.0 7.6e-16 58.4 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EMC80278.1 - 3.5e-13 50.2 0.0 5.7e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain dCache_1 PF02743.18 EMC80278.1 - 8.2e-13 48.7 3.0 3.9e-10 39.9 0.0 4.0 2 2 1 3 3 3 1 Cache domain VWA_2 PF13519.6 EMC80278.1 - 1.2e-11 45.2 0.0 2.5e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 EMC80278.1 - 0.082 12.3 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein LRR_8 PF13855.6 EMC80279.1 - 3.5e-24 84.3 26.2 2.6e-12 46.3 0.9 3.2 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EMC80279.1 - 1.6e-11 44.2 17.7 0.0013 19.1 2.9 3.6 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRRNT PF01462.18 EMC80279.1 - 7.9e-09 35.0 4.0 7.9e-09 35.0 4.0 2.3 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_5 PF13306.6 EMC80279.1 - 3.2e-08 33.6 0.0 4.8e-07 29.8 0.0 2.5 2 1 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC80279.1 - 5.1e-05 22.8 4.1 0.00032 20.3 3.1 2.0 1 1 1 2 2 2 2 Leucine-rich repeat Shisa PF13908.6 EMC80279.1 - 0.0071 16.6 0.2 0.012 15.9 0.2 1.3 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator LRR_1 PF00560.33 EMC80279.1 - 0.0071 16.7 17.7 0.034 14.7 0.7 5.1 4 1 0 4 4 4 1 Leucine Rich Repeat LRR_6 PF13516.6 EMC80279.1 - 2.4 8.4 9.6 52 4.3 0.1 4.9 5 0 0 5 5 5 0 Leucine Rich repeat HlyIII PF03006.20 EMC80280.1 - 1.8e-72 243.7 21.2 2.2e-72 243.4 21.2 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF3493 PF11998.8 EMC80280.1 - 0.25 11.5 1.3 1.5 9.0 1.3 2.3 1 1 0 1 1 1 0 Low psii accumulation1 / Rep27 wnt PF00110.19 EMC80281.1 - 8.4e-121 403.3 21.8 9.5e-121 403.1 21.8 1.0 1 0 0 1 1 1 1 wnt family LRR_6 PF13516.6 EMC80282.1 - 4.7e-22 76.1 44.3 0.00029 20.6 0.2 11.4 12 0 0 12 12 12 8 Leucine Rich repeat LRR_4 PF12799.7 EMC80282.1 - 3.3e-17 62.3 18.3 0.0073 16.7 1.5 7.0 5 2 2 7 7 7 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMC80282.1 - 0.00075 19.2 24.5 4.8 7.0 2.6 7.6 3 2 4 7 7 7 2 Leucine rich repeat LRR_1 PF00560.33 EMC80282.1 - 0.0012 19.0 39.7 11 7.0 1.1 10.2 9 3 0 9 9 9 1 Leucine Rich Repeat SAM_Ste50p PF09235.10 EMC80282.1 - 0.0033 17.6 4.5 0.26 11.5 0.3 4.4 4 1 1 5 5 5 1 Ste50p, sterile alpha motif LRR_2 PF07723.13 EMC80282.1 - 0.073 13.8 8.7 21 6.0 0.1 6.0 6 0 0 6 6 6 0 Leucine Rich Repeat Bac_DnaA_C PF08299.11 EMC80282.1 - 0.13 12.3 0.0 0.99 9.5 0.0 2.4 2 0 0 2 2 2 0 Bacterial dnaA protein helix-turn-helix Cast PF10174.9 EMC80283.1 - 0 1092.4 148.0 0 1092.2 148.0 1.0 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone PKcGMP_CC PF16808.5 EMC80283.1 - 0.0022 17.8 0.6 0.0022 17.8 0.6 12.5 13 3 2 15 15 15 4 Coiled-coil N-terminus of cGMP-dependent protein kinase Spc7 PF08317.11 EMC80283.1 - 0.0036 16.2 17.7 0.0036 16.2 17.7 7.5 1 1 5 7 7 7 4 Spc7 kinetochore protein AAA_13 PF13166.6 EMC80283.1 - 0.0038 16.0 26.4 0.0038 16.0 26.4 5.1 1 1 4 5 5 5 1 AAA domain Troponin PF00992.20 EMC80283.1 - 0.013 15.8 21.5 0.013 15.8 21.5 8.2 2 2 5 8 8 8 0 Troponin Phage_tail_NK PF16532.5 EMC80283.1 - 7.5 6.2 8.2 8.3 6.0 0.5 3.6 3 0 0 3 3 3 0 Sf6-type phage tail needle knob or tip of some Caudovirales Rad52_Rad22 PF04098.15 EMC80284.1 - 5e-49 166.1 0.5 8.1e-49 165.5 0.0 1.6 2 0 0 2 2 2 1 Rad52/22 family double-strand break repair protein Ninjurin PF04923.12 EMC80285.1 - 2.4e-34 117.4 12.0 2.7e-34 117.2 12.0 1.0 1 0 0 1 1 1 1 Ninjurin DUF4231 PF14015.6 EMC80285.1 - 0.56 10.7 3.7 1 9.9 3.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) DUF4577 PF15145.6 EMC80285.1 - 2.1 8.4 5.5 0.56 10.2 2.4 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4577) Phage_lysozyme PF00959.19 EMC80286.1 - 0.023 15.1 1.3 5.2 7.6 0.4 2.8 1 1 1 2 2 2 0 Phage lysozyme Fez1 PF06818.15 EMC80286.1 - 0.094 13.2 43.9 0.16 12.4 18.6 4.1 2 1 3 5 5 5 0 Fez1 PLU-1 PF08429.11 EMC80287.1 - 1.3e-101 340.2 11.6 1.3e-101 340.2 11.6 4.2 3 1 0 3 3 3 2 PLU-1-like protein JmjC PF02373.22 EMC80287.1 - 2.4e-46 156.8 1.4 7.3e-46 155.3 1.4 1.9 1 0 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.29 EMC80287.1 - 2.1e-25 88.3 46.9 2.3e-12 46.6 3.3 3.9 4 0 0 4 4 4 3 PHD-finger ARID PF01388.21 EMC80287.1 - 1.2e-18 67.5 0.1 3.9e-18 65.9 0.0 2.0 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain zf-C5HC2 PF02928.16 EMC80287.1 - 1.7e-14 53.9 12.4 1.7e-14 53.9 12.4 3.5 4 0 0 4 4 4 1 C5HC2 zinc finger FRG1 PF06229.12 EMC80287.1 - 0.18 11.5 11.5 5.8 6.6 0.0 2.7 2 0 0 2 2 2 0 FRG1-like domain PHD_2 PF13831.6 EMC80287.1 - 0.43 10.2 20.0 0.7 9.5 0.5 3.8 3 1 0 3 3 3 0 PHD-finger TadF PF16964.5 EMC80287.1 - 1.5 8.5 6.3 3.3 7.4 2.5 2.7 2 0 0 2 2 2 0 Putative tight adherence pilin protein F zf-PHD-like PF15446.6 EMC80287.1 - 5.4 6.6 18.9 0.15 11.7 0.6 4.2 4 0 0 4 4 4 0 PHD/FYVE-zinc-finger like domain SNF PF00209.18 EMC80288.1 - 4.8e-246 817.5 36.8 5.5e-246 817.3 36.8 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family SNF PF00209.18 EMC80289.1 - 3e-243 808.3 36.8 3.4e-243 808.1 36.8 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family SNF PF00209.18 EMC80290.1 - 3.9e-229 761.7 40.1 4.6e-229 761.5 40.1 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Sec7 PF01369.20 EMC80291.1 - 4.1e-62 209.1 0.0 1e-61 207.8 0.0 1.7 1 0 0 1 1 1 1 Sec7 domain IQ_SEC7_PH PF16453.5 EMC80291.1 - 1.5e-61 206.4 2.5 2.4e-61 205.7 0.8 2.2 2 0 0 2 2 2 1 PH domain IQ PF00612.27 EMC80291.1 - 0.4 10.6 2.2 0.53 10.2 0.3 2.2 2 0 0 2 2 2 0 IQ calmodulin-binding motif zf-H2C2_2 PF13465.6 EMC80292.1 - 4.2e-85 276.7 82.4 1.4e-10 41.1 0.5 13.4 13 1 0 13 13 13 13 Zinc-finger double domain zf-C2H2 PF00096.26 EMC80292.1 - 4.2e-77 250.5 90.3 1.3e-07 31.7 1.9 12.3 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC80292.1 - 7e-47 154.0 84.8 0.00033 21.2 0.2 12.3 12 0 0 12 12 12 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC80292.1 - 8.3e-27 92.9 41.6 0.019 15.3 0.1 12.2 12 0 0 12 12 12 7 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMC80292.1 - 1.4e-24 85.5 77.8 0.0026 17.7 0.4 12.4 12 0 0 12 12 12 9 C2H2-type zinc finger zf-met PF12874.7 EMC80292.1 - 7.8e-14 51.5 73.6 0.082 13.3 0.2 11.9 12 0 0 12 12 12 9 Zinc-finger of C2H2 type zf_UBZ PF18439.1 EMC80292.1 - 9.9e-14 50.6 52.0 0.07 12.7 0.3 12.0 11 1 1 12 12 12 6 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 EMC80292.1 - 6e-12 45.5 64.5 0.021 14.9 3.6 8.3 5 3 4 9 9 9 7 Zinc ribbon domain zinc_ribbon_15 PF17032.5 EMC80292.1 - 4.1e-09 37.1 41.5 0.14 13.0 4.1 6.2 3 1 3 6 6 6 6 zinc-ribbon family XPA_N PF01286.18 EMC80292.1 - 6.9e-08 32.4 58.7 0.79 9.8 0.4 11.9 12 0 0 12 12 12 3 XPA protein N-terminal zf-C2H2_11 PF16622.5 EMC80292.1 - 9.8e-08 31.6 68.8 0.073 12.9 0.3 12.1 12 0 0 12 12 12 7 zinc-finger C2H2-type DNA_RNApol_7kD PF03604.13 EMC80292.1 - 0.00029 20.4 46.8 2.2 8.1 0.1 11.8 12 0 0 12 12 12 2 DNA directed RNA polymerase, 7 kDa subunit HalOD2 PF18547.1 EMC80292.1 - 0.0015 18.4 0.3 0.0015 18.4 0.3 8.2 8 2 1 9 9 9 3 Halobacterial output domain 2 HypA PF01155.19 EMC80292.1 - 0.002 18.1 43.5 0.035 14.1 0.1 6.7 1 1 4 5 5 4 3 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-Di19 PF05605.12 EMC80292.1 - 0.0055 17.0 8.7 0.024 15.0 0.9 7.2 4 2 3 8 8 8 2 Drought induced 19 protein (Di19), zinc-binding zf-LYAR PF08790.11 EMC80292.1 - 0.0089 15.9 50.3 1.2 9.1 0.4 11.0 12 0 0 12 12 11 2 LYAR-type C2HC zinc finger FYDLN_acid PF09538.10 EMC80292.1 - 0.01 16.5 34.1 30 5.3 0.1 10.3 2 2 6 9 9 9 0 Protein of unknown function (FYDLN_acid) LIM PF00412.22 EMC80292.1 - 0.018 15.3 52.6 0.19 12.0 4.2 8.5 4 3 4 8 8 8 0 LIM domain Zn_Tnp_IS1595 PF12760.7 EMC80292.1 - 0.066 13.2 65.2 0.29 11.1 0.7 8.4 5 2 4 9 9 8 0 Transposase zinc-ribbon domain Raffinose_syn PF05691.12 EMC80292.1 - 0.1 10.3 5.1 4.3 5.0 0.0 3.9 3 1 0 4 4 4 0 Raffinose synthase or seed imbibition protein Sip1 Rad50_zn_hook PF04423.14 EMC80292.1 - 0.26 11.1 6.3 0.92 9.4 0.1 3.6 4 0 0 4 4 2 0 Rad50 zinc hook motif YhfH PF14149.6 EMC80292.1 - 0.33 11.0 45.9 7.6 6.6 0.1 10.8 11 0 0 11 11 11 0 YhfH-like protein Zn-C2H2_12 PF18112.1 EMC80292.1 - 0.57 10.7 0.1 0.57 10.7 0.1 7.4 9 0 0 9 9 8 0 Autophagy receptor zinc finger-C2H2 domain C1_4 PF07975.12 EMC80292.1 - 0.81 10.0 54.1 0.41 10.9 4.6 8.5 2 2 6 9 9 8 0 TFIIH C1-like domain DUF2072 PF09845.9 EMC80292.1 - 1.2 9.4 48.5 2.9 8.2 0.7 10.5 10 2 2 12 12 12 0 Zn-ribbon containing protein zf-C2HE PF16278.5 EMC80292.1 - 2.8 8.5 64.8 3 8.4 0.6 11.1 2 2 8 11 11 11 0 C2HE / C2H2 / C2HC zinc-binding finger HNH PF01844.23 EMC80292.1 - 3 8.1 57.8 0.87 9.8 0.2 11.6 12 0 0 12 12 12 0 HNH endonuclease BolA PF01722.18 EMC80292.1 - 3.6 7.9 15.5 9.6 6.6 0.1 4.8 3 1 3 6 6 5 0 BolA-like protein CpXC PF14353.6 EMC80292.1 - 3.8 7.6 45.7 1.2 9.2 0.1 10.4 3 3 5 8 8 8 0 CpXC protein GAGA PF09237.11 EMC80292.1 - 4.3 7.2 29.3 9.3 6.1 0.0 7.4 3 2 5 8 8 8 0 GAGA factor DUF3268 PF11672.8 EMC80292.1 - 4.5 7.6 37.6 2.4 8.5 0.3 6.9 2 1 5 9 9 9 0 zinc-finger-containing domain PBP_sp32 PF07222.12 EMC80293.1 - 9.5e-31 107.1 0.3 1.1e-30 106.9 0.3 1.0 1 0 0 1 1 1 1 Proacrosin binding protein sp32 IBN_N PF03810.19 EMC80294.1 - 4.2e-19 68.2 0.0 5.8e-17 61.4 0.0 3.5 3 0 0 3 3 3 1 Importin-beta N-terminal domain Cse1 PF08506.10 EMC80294.1 - 7.6e-09 34.9 3.3 7.6e-09 34.9 3.3 3.1 2 1 0 3 3 3 1 Cse1 DUF1539 PF07560.11 EMC80294.1 - 0.0086 16.2 1.9 0.28 11.3 0.1 3.2 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1539) RTP1_C1 PF10363.9 EMC80294.1 - 0.15 12.3 1.7 3.6 7.8 0.5 3.6 2 1 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 BUD22 PF09073.10 EMC80294.1 - 0.19 11.0 5.2 0.39 10.0 5.2 1.4 1 0 0 1 1 1 0 BUD22 Cwf_Cwc_15 PF04889.12 EMC80294.1 - 0.26 11.0 7.7 0.52 10.0 7.7 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF5367 PF17329.2 EMC80294.1 - 0.26 11.4 1.4 2.8 8.1 0.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5367) Xpo1 PF08389.12 EMC80294.1 - 0.41 10.7 11.7 0.077 13.1 0.5 4.0 4 1 0 4 4 4 0 Exportin 1-like protein FAM60A PF15396.6 EMC80295.1 - 8.7e-83 277.5 10.4 1.1e-82 277.1 10.4 1.1 1 0 0 1 1 1 1 Protein Family FAM60A PrmA PF06325.13 EMC80296.1 - 2.4e-10 40.3 0.1 3.6e-10 39.7 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 EMC80296.1 - 2.1e-09 37.4 0.0 5.8e-09 35.9 0.0 1.6 1 1 0 1 1 1 1 Lysine methyltransferase Met_10 PF02475.16 EMC80296.1 - 0.00019 21.3 0.0 0.00029 20.6 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.14 EMC80296.1 - 0.0053 16.3 0.0 0.0073 15.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 EMC80296.1 - 0.03 14.0 0.0 0.048 13.3 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 EMC80296.1 - 0.14 12.9 0.0 0.25 12.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain LRR_6 PF13516.6 EMC80297.1 - 3.4e-14 51.6 11.0 0.019 15.0 0.0 7.1 7 0 0 7 7 7 5 Leucine Rich repeat LRR_4 PF12799.7 EMC80297.1 - 3.1e-06 27.4 5.7 0.0039 17.6 1.1 4.1 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC80297.1 - 0.003 17.9 5.2 69 4.6 0.1 5.2 4 2 0 4 4 4 0 Leucine Rich Repeat DUF4617 PF15395.6 EMC80298.1 - 1.2e-301 1004.0 111.2 1.2e-301 1004.0 111.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4617) BicD PF09730.9 EMC80299.1 - 0 1150.9 63.2 0 1150.7 63.2 1.0 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D Med4 PF10018.9 EMC80299.1 - 0.00053 19.7 1.3 0.00053 19.7 1.3 5.2 4 2 1 5 5 5 1 Vitamin-D-receptor interacting Mediator subunit 4 DUF1759 PF03564.15 EMC80299.1 - 0.0025 17.8 5.9 0.0025 17.8 5.9 5.1 4 1 0 5 5 5 1 Protein of unknown function (DUF1759) ApoO PF09769.9 EMC80299.1 - 1.2 9.2 14.1 0.13 12.2 0.8 3.9 3 2 0 3 3 3 0 Apolipoprotein O RhoGEF PF00621.20 EMC80300.1 - 1e-46 159.4 0.6 1e-46 159.4 0.6 1.7 2 0 0 2 2 1 1 RhoGEF domain PH PF00169.29 EMC80300.1 - 1.5e-25 89.8 0.6 1.9e-12 47.6 0.0 3.3 2 1 1 3 3 3 2 PH domain FYVE PF01363.21 EMC80300.1 - 6.5e-18 64.6 11.4 1.7e-17 63.3 11.4 1.7 1 0 0 1 1 1 1 FYVE zinc finger IQ_SEC7_PH PF16453.5 EMC80300.1 - 9.4e-08 32.1 0.4 1.7e-06 28.1 0.3 2.5 2 0 0 2 2 2 1 PH domain PH_13 PF16652.5 EMC80300.1 - 5.3e-06 26.3 3.2 0.014 15.2 2.9 3.6 2 1 0 2 2 2 1 Pleckstrin homology domain PH_6 PF15406.6 EMC80300.1 - 0.00076 19.7 0.0 1.7 9.0 0.0 2.7 2 0 0 2 2 2 2 Pleckstrin homology domain FYVE_2 PF02318.16 EMC80300.1 - 0.0014 18.8 11.6 0.0053 17.0 10.9 2.4 1 1 0 1 1 1 1 FYVE-type zinc finger PH_11 PF15413.6 EMC80300.1 - 0.0043 17.5 1.4 1.3 9.5 0.0 3.7 2 1 0 2 2 2 1 Pleckstrin homology domain PH_2 PF08458.10 EMC80300.1 - 0.0049 17.2 0.3 0.89 9.9 0.1 3.1 3 0 0 3 3 3 1 Plant pleckstrin homology-like region Presenilin PF01080.17 EMC80300.1 - 0.053 12.3 1.6 0.094 11.5 1.6 1.3 1 0 0 1 1 1 0 Presenilin PH_5 PF15405.6 EMC80300.1 - 0.082 13.0 0.3 8.4 6.5 0.1 3.1 1 1 1 2 2 2 0 Pleckstrin homology domain zf-RING_UBOX PF13445.6 EMC80300.1 - 0.13 12.3 6.4 0.48 10.5 6.4 2.0 1 1 0 1 1 1 0 RING-type zinc-finger PH_16 PF17838.1 EMC80300.1 - 0.24 11.3 2.2 3.5 7.5 0.1 2.8 3 0 0 3 3 3 0 PH domain zf-RING_5 PF14634.6 EMC80300.1 - 0.24 11.4 12.7 0.55 10.2 12.7 1.7 1 0 0 1 1 1 0 zinc-RING finger domain DUF4162 PF13732.6 EMC80300.1 - 4.4 8.1 9.2 1.9 9.3 0.1 4.1 5 0 0 5 5 4 0 Domain of unknown function (DUF4162) IBR PF01485.21 EMC80300.1 - 6.1 7.2 13.3 23 5.3 13.0 2.2 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain Dynamin_M PF01031.20 EMC80301.1 - 3e-104 348.2 0.0 1e-103 346.5 0.0 1.9 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 EMC80301.1 - 1.9e-50 171.2 0.5 4.7e-50 169.9 0.1 1.8 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 EMC80301.1 - 1.9e-31 108.1 2.7 1.9e-31 108.1 2.7 2.0 2 0 0 2 2 2 1 Dynamin GTPase effector domain tRNA-synt_1b PF00579.25 EMC80302.1 - 5.2e-31 108.1 0.0 6.3e-31 107.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) S4 PF01479.25 EMC80302.1 - 0.022 14.5 0.1 0.043 13.5 0.1 1.6 1 0 0 1 1 1 0 S4 domain PDZ PF00595.24 EMC80303.1 - 7.1e-83 273.0 25.6 2.8e-16 59.6 0.3 7.2 7 0 0 7 7 7 7 PDZ domain PDZ_6 PF17820.1 EMC80303.1 - 1.6e-42 143.1 9.3 4.4e-08 32.9 0.5 6.6 7 0 0 7 7 7 5 PDZ domain PDZ_2 PF13180.6 EMC80303.1 - 6.2e-26 90.5 15.0 1e-05 25.8 0.5 6.9 6 1 1 7 7 7 6 PDZ domain MPDZ_u10 PF16667.5 EMC80303.1 - 2.8e-22 79.4 13.2 2.8e-22 79.4 13.2 2.8 2 0 0 2 2 2 1 Unstructured region 10 on multiple PDZ protein PDZ_1 PF12812.7 EMC80303.1 - 0.022 14.8 0.1 10 6.2 0.0 3.2 3 0 0 3 3 3 0 PDZ-like domain LURAP PF14854.6 EMC80304.1 - 1.5e-39 134.6 1.3 1.9e-39 134.3 1.3 1.1 1 0 0 1 1 1 1 Leucine rich adaptor protein Tyrosinase PF00264.20 EMC80305.1 - 2.6e-33 116.2 0.1 7.2e-33 114.7 0.1 1.7 2 0 0 2 2 2 1 Common central domain of tyrosinase Laminin_EGF PF00053.24 EMC80305.1 - 0.71 10.1 13.4 1 9.5 9.8 2.7 2 1 0 2 2 2 0 Laminin EGF domain Yae1_N PF09811.9 EMC80306.1 - 4.6e-08 32.6 33.9 1.1 9.0 24.5 4.4 1 1 1 2 2 2 2 Essential protein Yae1, N terminal gp45-slide_C PF09116.10 EMC80307.1 - 0.0046 17.0 0.3 0.0082 16.2 0.3 1.5 1 1 0 1 1 1 1 gp45 sliding clamp, C terminal PSP1 PF04468.12 EMC80307.1 - 0.017 15.4 0.2 0.049 13.9 0.2 1.7 1 0 0 1 1 1 0 PSP1 C-terminal conserved region Y_phosphatase PF00102.27 EMC80308.1 - 2.5e-166 550.9 0.3 3.3e-82 275.6 0.0 2.3 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 EMC80308.1 - 8.6e-111 362.5 28.9 1.6e-16 60.4 0.3 10.4 10 1 0 10 10 9 8 Fibronectin type III domain Ig_3 PF13927.6 EMC80308.1 - 1.2e-25 89.9 0.4 1.1e-11 45.2 0.0 4.9 4 0 0 4 4 4 2 Immunoglobulin domain I-set PF07679.16 EMC80308.1 - 3.2e-22 78.4 0.0 3.4e-12 46.3 0.0 3.5 4 0 0 4 4 2 2 Immunoglobulin I-set domain Pur_ac_phosph_N PF16656.5 EMC80308.1 - 1.6e-16 60.6 19.3 0.048 14.2 0.3 9.4 8 2 1 9 9 9 4 Purple acid Phosphatase, N-terminal domain Ig_2 PF13895.6 EMC80308.1 - 4.9e-15 55.6 0.1 1.4e-07 31.7 0.0 3.7 3 0 0 3 3 3 2 Immunoglobulin domain fn3_2 PF16893.5 EMC80308.1 - 4.6e-11 42.7 3.6 0.11 12.6 0.0 8.0 7 2 0 7 7 7 2 Fibronectin type III domain Interfer-bind PF09294.10 EMC80308.1 - 3.6e-10 40.1 0.2 0.31 11.4 0.0 7.0 7 0 0 7 7 6 2 Interferon-alpha/beta receptor, fibronectin type III ig PF00047.25 EMC80308.1 - 1.7e-08 34.5 0.0 0.0074 16.4 0.0 3.2 3 0 0 3 3 2 2 Immunoglobulin domain DSPc PF00782.20 EMC80308.1 - 2.9e-08 33.6 0.0 0.0056 16.5 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC80308.1 - 7.9e-07 29.3 0.0 0.048 13.6 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EMC80308.1 - 9.9e-06 25.7 0.0 0.0053 16.9 0.0 2.7 2 0 0 2 2 2 1 Inositol hexakisphosphate fn3_4 PF16794.5 EMC80308.1 - 0.00011 22.1 5.4 0.31 11.0 0.0 7.0 9 0 0 9 9 9 1 Fibronectin-III type domain DUF2369 PF10179.9 EMC80308.1 - 0.0022 18.4 0.5 41 4.7 0.0 6.1 8 0 0 8 8 6 0 Uncharacterised conserved protein (DUF2369) Ig_5 PF16681.5 EMC80308.1 - 0.0045 17.3 0.0 0.19 12.1 0.0 2.9 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_C17orf99 PF17736.1 EMC80308.1 - 0.0067 16.4 0.1 1.3 9.1 0.0 3.7 4 0 0 4 4 4 1 C17orf99 Ig domain V-set PF07686.17 EMC80308.1 - 0.0087 16.2 0.0 3.2 8.0 0.0 4.1 2 1 0 2 2 2 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC80308.1 - 0.028 14.5 0.0 2.7 8.1 0.0 2.7 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Glyco_hydro_46 PF01374.18 EMC80308.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 46 Tudor_2 PF18104.1 EMC80309.1 - 5.2e-17 61.2 1.3 3.2e-16 58.7 0.0 2.5 2 0 0 2 2 2 1 Jumonji domain-containing protein 2A Tudor domain LBR_tudor PF09465.10 EMC80309.1 - 4.4e-05 23.2 0.2 8e-05 22.4 0.2 1.4 1 0 0 1 1 1 1 Lamin-B receptor of TUDOR domain Tudor_3 PF18115.1 EMC80309.1 - 0.003 17.3 0.0 0.036 13.9 0.0 2.6 1 1 1 2 2 2 1 DNA repair protein Crb2 Tudor domain CopK PF11525.8 EMC80309.1 - 0.012 15.2 0.0 0.02 14.5 0.0 1.4 1 0 0 1 1 1 0 Copper resistance protein K Rad9_Rad53_bind PF08605.10 EMC80309.1 - 0.015 15.5 0.0 0.019 15.1 0.0 1.2 1 0 0 1 1 1 0 Fungal Rad9-like Rad53-binding JmjC PF02373.22 EMC80310.1 - 5.3e-41 139.6 0.1 1.2e-40 138.5 0.1 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase TTD PF12148.8 EMC80311.1 - 2.7e-67 225.5 0.6 5.8e-67 224.4 0.6 1.6 1 0 0 1 1 1 1 Tandem tudor domain within UHRF1 SAD_SRA PF02182.17 EMC80311.1 - 3.9e-54 182.6 0.6 4.8e-53 179.0 0.1 2.3 2 0 0 2 2 2 1 SAD/SRA domain PHD PF00628.29 EMC80311.1 - 1.1e-09 38.0 11.2 1.1e-09 38.0 11.2 3.6 2 2 1 3 3 2 1 PHD-finger zf-C3HC4_2 PF13923.6 EMC80311.1 - 0.00026 20.8 13.6 0.00026 20.8 13.6 3.0 2 1 1 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMC80311.1 - 0.00033 20.5 10.4 0.00033 20.5 10.4 4.1 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC80311.1 - 0.00046 20.1 10.7 0.00046 20.1 10.7 3.6 2 1 0 2 2 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EMC80311.1 - 0.00051 19.9 13.3 0.00051 19.9 13.3 2.9 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.5 EMC80311.1 - 0.0014 18.7 6.5 0.0014 18.7 6.5 3.0 2 1 0 2 2 2 1 zinc RING finger of MSL2 zf-RING_UBOX PF13445.6 EMC80311.1 - 0.0018 18.3 10.2 0.0074 16.3 10.2 2.2 1 0 0 1 1 1 1 RING-type zinc-finger PHD_2 PF13831.6 EMC80311.1 - 0.0072 15.9 1.4 0.0072 15.9 1.4 3.6 3 0 0 3 3 3 1 PHD-finger ubiquitin PF00240.23 EMC80311.1 - 0.14 11.9 0.1 0.44 10.3 0.1 1.9 1 0 0 1 1 1 0 Ubiquitin family zf-RING_2 PF13639.6 EMC80311.1 - 2.8 8.3 36.4 0.038 14.3 13.2 3.0 2 1 0 2 2 2 0 Ring finger domain HPS3_N PF14761.6 EMC80314.1 - 0.0053 16.3 1.5 0.29 10.6 0.0 2.9 3 0 0 3 3 3 2 Hermansky-Pudlak syndrome 3 MLANA PF14991.6 EMC80315.1 - 2.4e-47 160.1 0.0 3.1e-47 159.7 0.0 1.2 1 0 0 1 1 1 1 Protein melan-A DUF4131 PF13567.6 EMC80315.1 - 0.083 12.5 0.5 0.1 12.2 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) SKG6 PF08693.10 EMC80315.1 - 0.67 9.4 2.8 1.1 8.7 2.8 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain MFS_1 PF07690.16 EMC80316.1 - 2.4e-34 118.8 41.4 9.6e-24 84.0 24.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily ATG22 PF11700.8 EMC80316.1 - 6.3e-06 25.1 2.2 6.3e-06 25.1 2.2 2.3 2 0 0 2 2 2 1 Vacuole effluxer Atg22 like DUF2721 PF11026.8 EMC80316.1 - 0.097 12.6 0.0 0.097 12.6 0.0 3.7 2 2 1 3 3 3 0 Protein of unknown function (DUF2721) SLATT_5 PF18160.1 EMC80316.1 - 6.3 6.1 10.1 0.73 9.1 1.1 2.8 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain family 5 RIC1 PF07064.13 EMC80318.1 - 1.6e-80 270.2 1.1 2.5e-80 269.5 1.1 1.3 1 0 0 1 1 1 1 RIC1 ANAPC4_WD40 PF12894.7 EMC80318.1 - 2.2e-05 24.7 0.0 0.19 12.0 0.0 3.9 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ig_3 PF13927.6 EMC80319.1 - 2.2e-11 44.2 0.0 8.4e-05 23.1 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 EMC80319.1 - 4.9e-07 29.9 0.1 1.2e-06 28.6 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 EMC80319.1 - 8e-07 29.1 0.4 0.06 13.5 0.0 3.0 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 EMC80319.1 - 2.3e-06 27.8 0.3 0.032 14.6 0.0 3.1 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC80319.1 - 5e-06 26.5 0.2 0.068 13.3 0.1 2.9 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_6 PF18452.1 EMC80319.1 - 0.0014 18.1 0.0 0.0075 15.8 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.12 EMC80319.1 - 0.0043 17.1 0.0 0.03 14.4 0.0 2.3 1 1 1 2 2 2 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 EMC80319.1 - 0.0067 16.8 0.5 0.015 15.7 0.1 1.8 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.6 EMC80320.1 - 6e-14 52.4 0.5 6.6e-07 29.8 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC80320.1 - 5.9e-12 45.5 0.3 1.4e-06 28.3 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 EMC80320.1 - 2.4e-11 43.8 1.1 6.3e-11 42.4 0.0 2.0 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.6 EMC80320.1 - 1.8e-08 34.6 0.7 0.0034 17.7 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 EMC80320.1 - 1.6e-07 31.4 2.8 0.0015 18.7 0.1 2.8 2 1 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 EMC80320.1 - 9.3e-07 28.8 0.1 4.1e-05 23.6 0.2 2.2 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 EMC80320.1 - 0.00091 19.6 1.3 0.06 13.7 0.3 2.4 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_6 PF18452.1 EMC80320.1 - 0.048 13.2 0.0 0.12 11.9 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain DUF2368 PF10166.9 EMC80321.1 - 2.9e-47 159.7 0.0 3.3e-47 159.5 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2368) Insulin PF00049.18 EMC80322.1 - 0.015 16.2 0.1 0.017 16.1 0.1 1.3 1 1 0 1 1 1 0 Insulin/IGF/Relaxin family CAF20 PF17052.5 EMC80322.1 - 0.15 12.2 0.0 0.2 11.8 0.0 1.1 1 0 0 1 1 1 0 Cap associated factor Pkinase_Tyr PF07714.17 EMC80323.1 - 8.8e-146 484.0 0.0 3.1e-85 285.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 EMC80323.1 - 4.9e-74 249.0 0.0 1.5e-50 172.0 0.0 2.7 3 0 0 3 3 3 2 Protein kinase domain FERM_F2 PF18377.1 EMC80323.1 - 3.8e-44 149.8 0.1 9.4e-44 148.5 0.1 1.7 1 0 0 1 1 1 1 FERM F2 acyl-CoA binding protein-like domain FERM_F1 PF18379.1 EMC80323.1 - 1.5e-39 133.9 0.5 1.5e-39 133.9 0.5 2.1 3 0 0 3 3 3 1 FERM F1 ubiquitin-like domain Jak1_Phl PF17887.1 EMC80323.1 - 5.8e-19 68.5 0.6 1.7e-18 67.0 0.2 1.9 1 1 1 2 2 2 1 Jak1 pleckstrin homology-like domain Kdo PF06293.14 EMC80323.1 - 3e-06 26.7 0.6 0.014 14.7 0.2 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EMC80323.1 - 8.5e-05 22.0 0.0 0.0079 15.6 0.0 2.8 2 1 0 2 2 2 1 Kinase-like RIO1 PF01163.22 EMC80323.1 - 0.0016 18.1 1.3 0.23 11.0 0.1 2.5 2 0 0 2 2 2 2 RIO1 family APH PF01636.23 EMC80323.1 - 0.018 15.0 0.0 1 9.2 0.0 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family RTC PF01137.21 EMC80324.1 - 4e-43 147.2 0.0 4.6e-43 147.0 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 EMC80324.1 - 3.3e-36 123.9 0.0 5.1e-36 123.3 0.0 1.3 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain Flavokinase PF01687.17 EMC80325.1 - 6.1e-12 45.8 0.1 7.3e-12 45.6 0.1 1.1 1 0 0 1 1 1 1 Riboflavin kinase Peptidase_S8 PF00082.22 EMC80326.1 - 7.8e-49 166.5 3.1 1.2e-48 166.0 3.1 1.3 1 0 0 1 1 1 1 Subtilase family Furin-like_2 PF15913.5 EMC80326.1 - 2.6e-34 117.6 340.2 3.2e-06 27.3 17.0 17.2 2 2 14 16 16 16 13 Furin-like repeat, cysteine-rich GF_recep_IV PF14843.6 EMC80326.1 - 1.5e-33 115.4 389.4 6.8e-09 35.6 41.2 13.9 2 2 12 14 14 14 10 Growth factor receptor domain IV P_proprotein PF01483.20 EMC80326.1 - 7.8e-31 105.9 0.0 1.4e-30 105.1 0.0 1.4 1 0 0 1 1 1 1 Proprotein convertase P-domain VSP PF03302.13 EMC80326.1 - 7.3e-22 77.8 335.5 0.00035 19.6 24.1 18.1 3 2 11 15 15 15 12 Giardia variant-specific surface protein S8_pro-domain PF16470.5 EMC80326.1 - 3.7e-12 46.9 0.6 8.3e-12 45.7 0.6 1.7 1 0 0 1 1 1 1 Peptidase S8 pro-domain Furin-like PF00757.20 EMC80326.1 - 2.6e-06 27.4 377.7 0.00037 20.4 33.3 14.3 1 1 10 12 12 12 6 Furin-like cysteine rich region Ank_2 PF12796.7 EMC80327.1 - 2.3e-24 85.8 3.0 3.7e-16 59.5 0.5 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC80327.1 - 4.9e-22 77.7 6.1 5.1e-09 36.2 0.3 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) SH3_1 PF00018.28 EMC80327.1 - 2.6e-16 59.0 0.0 4.8e-16 58.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain Ank_4 PF13637.6 EMC80327.1 - 6.7e-16 58.4 0.4 1.1e-07 32.3 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SH3_9 PF14604.6 EMC80327.1 - 9.2e-15 54.2 0.0 1.4e-14 53.6 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Ank PF00023.30 EMC80327.1 - 1.3e-13 50.7 0.4 2.4e-05 24.6 0.1 3.4 3 0 0 3 3 3 2 Ankyrin repeat SH3_2 PF07653.17 EMC80327.1 - 2.8e-13 49.3 0.0 5.7e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ank_3 PF13606.6 EMC80327.1 - 4.1e-10 39.0 0.1 0.014 15.9 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat AAA_18 PF13238.6 EMC80328.1 - 9.9e-14 52.0 0.0 2.9e-13 50.5 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EMC80328.1 - 0.12 12.6 0.0 0.4 10.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain N2227 PF07942.12 EMC80329.1 - 4.5e-112 373.7 0.2 5.5e-112 373.4 0.2 1.1 1 0 0 1 1 1 1 N2227-like protein RhoGAP PF00620.27 EMC80329.1 - 0.018 14.9 0.5 0.67 9.8 0.3 2.3 1 1 1 2 2 2 0 RhoGAP domain Methyltransf_12 PF08242.12 EMC80329.1 - 0.027 15.2 0.0 0.098 13.4 0.0 2.1 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 EMC80329.1 - 0.04 14.6 0.0 0.11 13.2 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EMC80329.1 - 0.079 12.8 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.6 EMC80329.1 - 0.2 12.7 0.0 0.47 11.5 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain LSDAT_euk PF18139.1 EMC80330.1 - 2.2e-119 397.8 0.1 3.2e-119 397.2 0.1 1.3 1 0 0 1 1 1 1 SLOG in TRPM Alpha_kinase PF02816.18 EMC80330.1 - 1.7e-43 148.9 0.0 4.6e-43 147.5 0.0 1.8 1 0 0 1 1 1 1 Alpha-kinase family TRPM_tetra PF16519.5 EMC80330.1 - 1.6e-26 92.2 2.3 5.8e-26 90.4 2.3 2.1 1 0 0 1 1 1 1 Tetramerisation domain of TRPM LSDAT_prok PF18171.1 EMC80330.1 - 1.3e-16 60.4 0.1 2.3e-16 59.6 0.1 1.4 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote Ion_trans PF00520.31 EMC80330.1 - 3.9e-12 45.9 17.2 7.2e-12 45.1 17.2 1.4 1 0 0 1 1 1 1 Ion transport protein Tmemb_18A PF09771.9 EMC80330.1 - 0.0094 16.3 0.3 11 6.4 0.1 3.6 3 0 0 3 3 3 1 Transmembrane protein 188 zf-C4 PF00105.18 EMC80331.1 - 2.3e-33 114.5 12.3 5.4e-33 113.3 12.3 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 EMC80331.1 - 6.9e-24 84.6 2.2 6.9e-24 84.6 2.2 1.8 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor Ras PF00071.22 EMC80332.1 - 4.5e-42 143.4 0.0 5.3e-42 143.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC80332.1 - 6.2e-29 100.6 0.0 8.7e-29 100.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC80332.1 - 1e-09 38.1 0.0 1.2e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EMC80332.1 - 1e-06 28.3 0.0 1.2e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region TniB PF05621.11 EMC80332.1 - 0.0029 17.0 0.0 0.0096 15.3 0.0 1.8 1 1 1 2 2 2 1 Bacterial TniB protein MMR_HSR1 PF01926.23 EMC80332.1 - 0.0061 16.6 0.0 0.0089 16.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_7 PF12775.7 EMC80332.1 - 0.012 15.1 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 EMC80332.1 - 0.018 15.3 0.0 0.03 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EMC80332.1 - 0.038 13.7 0.0 0.57 9.9 0.0 2.3 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 EMC80332.1 - 0.15 12.0 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Peptidase_C1 PF00112.23 EMC80333.1 - 4.4e-62 210.0 0.2 6.1e-62 209.5 0.2 1.2 1 0 0 1 1 1 1 Papain family cysteine protease CathepsinC_exc PF08773.11 EMC80333.1 - 4.7e-34 117.3 0.5 9.6e-34 116.3 0.5 1.5 1 0 0 1 1 1 1 Cathepsin C exclusion domain Peptidase_C1_2 PF03051.15 EMC80333.1 - 0.0003 19.7 0.7 0.0041 16.0 0.0 2.5 2 1 1 3 3 3 1 Peptidase C1-like family Propeptide_C1 PF08127.13 EMC80333.1 - 0.012 15.5 0.1 0.022 14.6 0.1 1.4 1 0 0 1 1 1 0 Peptidase family C1 propeptide 7tm_3 PF00003.22 EMC80334.1 - 1e-57 195.6 24.8 1.4e-57 195.1 24.8 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.28 EMC80334.1 - 1.8e-46 158.9 0.0 2.7e-46 158.3 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region GluR_Homer-bdg PF10606.9 EMC80334.1 - 1.3e-20 73.3 12.6 4.2e-20 71.7 12.6 2.0 1 0 0 1 1 1 1 Homer-binding domain of metabotropic glutamate receptor NCD3G PF07562.14 EMC80334.1 - 8.4e-16 57.7 13.1 1.7e-15 56.7 13.1 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR DUF5438 PF17506.2 EMC80334.1 - 0.093 13.1 0.5 0.31 11.4 0.5 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5438) ANF_receptor PF01094.28 EMC80335.1 - 8.9e-21 74.4 0.0 9.8e-21 74.2 0.0 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region Ferric_reduct PF01794.19 EMC80336.1 - 2.6e-23 82.5 5.3 2.6e-23 82.5 5.3 2.2 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EMC80336.1 - 1.2e-21 77.5 0.0 3.1e-20 72.9 0.0 2.2 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EMC80336.1 - 1.4e-15 57.3 0.0 3.1e-15 56.2 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EMC80336.1 - 0.15 12.7 0.0 0.45 11.2 0.0 1.8 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain Ni_hydr_CYTB PF01292.20 EMC80336.1 - 5.2 6.6 9.3 1.5e+02 1.9 9.3 2.4 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 ORMDL PF04061.14 EMC80336.1 - 9.5 6.0 8.5 1.7 8.5 2.8 2.3 2 0 0 2 2 2 0 ORMDL family TFR_dimer PF04253.15 EMC80338.1 - 8e-37 126.0 0.1 1.7e-36 125.0 0.1 1.6 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EMC80338.1 - 2e-18 66.8 0.0 7.1e-18 65.0 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M28 PA PF02225.22 EMC80338.1 - 6.8e-15 54.9 0.0 1.4e-14 53.9 0.0 1.5 1 0 0 1 1 1 1 PA domain PPR_3 PF13812.6 EMC80338.1 - 0.0086 16.1 0.5 0.027 14.5 0.0 2.1 2 0 0 2 2 2 1 Pentatricopeptide repeat domain TFR_dimer PF04253.15 EMC80339.1 - 2.1e-36 124.7 0.0 4.4e-36 123.7 0.0 1.6 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EMC80339.1 - 5.8e-19 68.6 0.0 2.2e-18 66.6 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M28 PA PF02225.22 EMC80339.1 - 1.3e-12 47.6 0.0 3.2e-12 46.3 0.0 1.7 1 0 0 1 1 1 1 PA domain CHORD PF04968.12 EMC80340.1 - 2.4e-54 181.9 23.2 3.7e-28 98.0 3.7 2.7 3 0 0 3 3 3 2 CHORD CS PF04969.16 EMC80340.1 - 4.8e-12 46.7 0.3 9.5e-12 45.8 0.3 1.5 1 0 0 1 1 1 1 CS domain RhoGAP PF00620.27 EMC80341.1 - 7.7e-07 29.1 0.0 1.1e-06 28.5 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain DUF1072 PF06380.11 EMC80341.1 - 0.033 14.1 0.3 1.3 9.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1072) Cadherin PF00028.17 EMC80343.1 - 0 1596.1 79.4 1.9e-22 79.5 0.0 34.7 34 0 0 34 34 34 33 Cadherin domain Cadherin_2 PF08266.12 EMC80343.1 - 5.3e-28 96.7 1.3 1.5 8.7 0.0 19.1 22 0 0 22 22 21 4 Cadherin-like RET_CLD1 PF17756.1 EMC80343.1 - 1.5e-25 89.9 1.9 0.0062 16.8 0.0 17.1 19 1 1 20 20 20 2 RET Cadherin like domain 1 Laminin_G_2 PF02210.24 EMC80343.1 - 5.3e-24 85.2 0.9 6.4e-23 81.7 0.1 3.4 3 0 0 3 3 3 1 Laminin G domain Laminin_G_1 PF00054.23 EMC80343.1 - 2.8e-17 63.2 0.0 1.1e-16 61.3 0.0 2.1 1 0 0 1 1 1 1 Laminin G domain Cadherin_3 PF16184.5 EMC80343.1 - 9.7e-17 61.0 67.7 0.029 14.4 0.5 21.5 25 0 0 25 25 25 9 Cadherin-like EGF PF00008.27 EMC80343.1 - 4.3e-09 36.5 61.3 0.00055 20.2 10.9 4.6 4 0 0 4 4 4 3 EGF-like domain EGF_CA PF07645.15 EMC80343.1 - 4.9e-05 23.4 10.6 4.9e-05 23.4 10.6 4.3 3 1 1 4 4 3 1 Calcium-binding EGF domain RMI1_C PF16099.5 EMC80343.1 - 0.00033 20.5 1.1 18 5.2 0.0 5.6 5 0 0 5 5 5 0 Recq-mediated genome instability protein 1, C-terminal OB-fold hEGF PF12661.7 EMC80343.1 - 0.0046 17.6 53.6 0.014 16.0 7.8 4.8 4 0 0 4 4 4 2 Human growth factor-like EGF Big_9 PF17963.1 EMC80343.1 - 0.13 13.1 0.0 0.13 13.1 0.0 19.5 22 0 0 22 22 21 0 Bacterial Ig domain Cadherin_4 PF17803.1 EMC80343.1 - 2.9 8.6 124.0 0.062 13.9 0.5 19.1 23 0 0 23 23 21 0 Bacterial cadherin-like domain 7tm_1 PF00001.21 EMC80344.1 - 9.1e-50 169.4 25.3 1.1e-49 169.2 25.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC80344.1 - 3e-12 46.7 26.7 6.1e-12 45.7 26.7 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 EMC80344.1 - 2.5e-08 33.7 21.4 3e-08 33.3 21.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC80344.1 - 0.00041 20.2 16.9 0.014 15.2 16.9 2.1 1 1 0 1 1 1 1 Olfactory receptor Aa_trans PF01490.18 EMC80345.1 - 5.2e-11 41.9 1.5 6.5e-11 41.6 1.5 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Aa_trans PF01490.18 EMC80346.1 - 5.1e-65 219.8 11.7 6.2e-65 219.5 11.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Spore_permease PF03845.13 EMC80346.1 - 0.0047 15.8 7.2 0.0047 15.8 7.2 2.3 2 0 0 2 2 2 2 Spore germination protein RhoGAP PF00620.27 EMC80347.1 - 3e-20 72.6 0.0 1.8e-10 40.9 0.0 2.3 2 0 0 2 2 2 2 RhoGAP domain NYD-SP12_N PF15015.6 EMC80348.1 - 2.3e-161 538.0 0.0 2.5e-161 537.8 0.0 1.0 1 0 0 1 1 1 1 Spermatogenesis-associated, N-terminal TPR_1 PF00515.28 EMC80348.1 - 0.074 12.9 0.1 0.64 9.9 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF5124 PF17160.4 EMC80348.1 - 0.15 12.9 0.0 0.29 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5124) RhoGEF PF00621.20 EMC80349.1 - 4.7e-43 147.5 0.6 9.3e-43 146.6 0.6 1.5 1 0 0 1 1 1 1 RhoGEF domain PTCB-BRCT PF12738.7 EMC80349.1 - 4e-25 87.5 0.2 1.2e-18 66.8 0.1 2.5 2 0 0 2 2 2 2 twin BRCT domain BRCT PF00533.26 EMC80349.1 - 5.7e-16 58.7 0.1 5.4e-07 29.9 0.0 2.9 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EMC80349.1 - 0.00042 20.6 0.0 1.5 9.2 0.1 2.7 2 0 0 2 2 2 2 DNA ligase 3 BRCT domain BRCT_2 PF16589.5 EMC80349.1 - 0.00097 19.5 0.0 0.019 15.3 0.0 2.6 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain SKA2 PF16740.5 EMC80349.1 - 0.067 13.0 0.1 0.2 11.4 0.1 1.8 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 Abhydrolase_3 PF07859.13 EMC80350.1 - 5e-55 186.6 0.2 1e-39 136.6 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 EMC80350.1 - 1.6e-07 30.6 0.0 2.6e-05 23.3 0.0 2.1 2 0 0 2 2 2 2 Carboxylesterase family Say1_Mug180 PF10340.9 EMC80350.1 - 4.1e-07 29.2 0.0 6.5e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 EMC80350.1 - 0.00066 19.2 0.0 0.0018 17.8 0.0 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 EMC80350.1 - 0.01 14.8 0.0 0.017 14.1 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme PuR_N PF09182.10 EMC80350.1 - 0.015 15.2 0.0 0.035 14.0 0.0 1.6 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal AXE1 PF05448.12 EMC80350.1 - 0.018 13.7 0.0 0.027 13.2 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) TNF PF00229.18 EMC80351.1 - 1.3e-36 125.3 0.2 2e-36 124.7 0.2 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.21 EMC80351.1 - 0.093 12.9 0.7 0.64 10.2 0.7 2.1 1 1 0 1 1 1 0 C1q domain 7tm_1 PF00001.21 EMC80352.1 - 7.7e-52 176.2 16.6 9.3e-52 175.9 16.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 EMC80352.1 - 3.9e-09 36.3 18.8 9.3e-09 35.0 18.8 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.6 EMC80352.1 - 1.8e-05 24.7 12.6 0.0001 22.2 12.6 2.1 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC80352.1 - 0.00013 21.7 14.4 0.00013 21.7 14.4 2.4 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 EMC80352.1 - 0.00046 19.7 19.1 0.00085 18.8 19.1 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx YIF1 PF03878.15 EMC80352.1 - 0.069 12.7 7.2 1.9 8.0 2.2 2.5 2 1 0 2 2 2 0 YIF1 zf-LITAF-like PF10601.9 EMC80352.1 - 1.5 9.1 8.7 16 5.8 0.0 4.0 3 1 0 3 3 3 0 LITAF-like zinc ribbon domain fn3 PF00041.21 EMC80353.1 - 2.1e-97 319.6 0.9 9.9e-11 41.8 0.0 9.9 9 1 0 9 9 9 9 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 EMC80353.1 - 4.4e-25 88.1 0.8 0.22 12.1 0.0 9.3 8 1 0 8 8 8 7 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 EMC80353.1 - 6.8e-13 48.8 0.0 0.029 14.7 0.0 7.2 8 0 0 8 8 8 4 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.10 EMC80353.1 - 4.3e-11 43.1 5.9 2.4 8.5 0.0 7.9 8 0 0 8 8 8 4 Interferon-alpha/beta receptor, fibronectin type III fn3_4 PF16794.5 EMC80353.1 - 4.4e-05 23.3 1.3 2.4 8.1 0.1 6.7 7 2 0 7 7 7 1 Fibronectin-III type domain fn3_2 PF16893.5 EMC80353.1 - 0.00015 21.8 0.0 2.7 8.2 0.0 5.3 5 0 0 5 5 5 1 Fibronectin type III domain PX PF00787.24 EMC80354.1 - 3.8e-21 75.2 3.5 1.2e-20 73.6 3.5 1.9 1 0 0 1 1 1 1 PX domain PLDc PF00614.22 EMC80354.1 - 1.6e-15 56.5 1.7 9.2e-08 32.0 0.1 3.3 3 0 0 3 3 3 2 Phospholipase D Active site motif PLDc_2 PF13091.6 EMC80354.1 - 7e-15 55.1 0.2 6.2e-09 35.8 0.1 3.1 2 1 0 2 2 2 2 PLD-like domain PH PF00169.29 EMC80354.1 - 1.3e-07 32.0 0.1 4e-07 30.5 0.1 1.9 1 0 0 1 1 1 1 PH domain DUF3785 PF12653.7 EMC80354.1 - 0.1 12.7 0.3 0.23 11.6 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3785) Pkinase PF00069.25 EMC80355.1 - 1e-65 221.7 0.0 3.2e-65 220.1 0.0 1.9 1 0 0 1 1 1 1 Protein kinase domain CNH PF00780.22 EMC80355.1 - 1.7e-60 205.0 0.0 2.6e-60 204.4 0.0 1.3 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.17 EMC80355.1 - 1.5e-48 165.3 0.0 2.8e-48 164.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Sugar_tr PF00083.24 EMC80356.1 - 3.8e-151 504.0 19.0 4.8e-151 503.6 19.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMC80356.1 - 2.2e-20 72.9 36.2 4.4e-17 62.0 24.7 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3054 PF11255.8 EMC80356.1 - 0.015 15.8 1.6 0.015 15.8 1.6 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3054) eIF-5a PF01287.20 EMC80357.1 - 1.1e-27 96.0 0.2 1.5e-27 95.5 0.2 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 EMC80357.1 - 0.004 17.2 0.4 0.0064 16.5 0.0 1.6 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain Ribosomal_L22e PF01776.17 EMC80358.1 - 5.6e-50 168.3 3.1 6.7e-50 168.0 3.1 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family AA_permease_2 PF13520.6 EMC80359.1 - 3e-45 154.8 57.8 1.5e-44 152.5 38.4 2.1 2 0 0 2 2 2 2 Amino acid permease AA_permease PF00324.21 EMC80359.1 - 1.7e-36 125.9 37.2 1.7e-36 125.9 37.2 2.4 2 1 0 2 2 2 1 Amino acid permease AA_permease_C PF13906.6 EMC80359.1 - 1.7e-20 72.8 9.9 1.7e-20 72.8 9.9 4.5 4 0 0 4 4 4 1 C-terminus of AA_permease PMP22_Claudin PF00822.20 EMC80360.1 - 1.1e-19 70.9 10.6 1.5e-19 70.5 10.6 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC80360.1 - 4.1e-05 23.4 13.7 0.0045 16.8 13.7 2.5 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Ski_Sno PF02437.17 EMC80361.1 - 5.1e-44 148.4 1.5 1.3e-43 147.2 1.5 1.7 1 0 0 1 1 1 1 SKI/SNO/DAC family c-SKI_SMAD_bind PF08782.10 EMC80361.1 - 1e-36 125.0 4.1 2.8e-36 123.6 4.1 1.8 1 0 0 1 1 1 1 c-SKI Smad4 binding domain DUF489 PF04356.12 EMC80361.1 - 1 9.4 12.0 0.23 11.5 7.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF489) Pkinase PF00069.25 EMC80362.1 - 2.6e-67 227.0 0.0 3.5e-67 226.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC80362.1 - 2.5e-34 118.8 0.0 3.6e-34 118.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 EMC80362.1 - 1.5e-14 53.6 10.1 3.1e-14 52.6 10.1 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PB1 PF00564.24 EMC80362.1 - 8.3e-11 41.7 0.0 2.3e-10 40.2 0.0 1.8 1 0 0 1 1 1 1 PB1 domain Pkinase_C PF00433.24 EMC80362.1 - 1.8e-05 25.3 2.3 5.3e-05 23.8 2.3 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 EMC80362.1 - 4.1e-05 23.0 0.0 6.6e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EMC80362.1 - 0.009 15.0 0.0 0.014 14.3 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain C1_2 PF03107.16 EMC80362.1 - 0.015 15.6 2.8 0.033 14.5 2.8 1.5 1 0 0 1 1 1 0 C1 domain FTA2 PF13095.6 EMC80362.1 - 0.028 14.0 0.1 0.73 9.4 0.0 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EMC80362.1 - 0.03 14.2 0.0 0.094 12.6 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EMC80362.1 - 0.032 13.6 0.0 0.055 12.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SAM_1 PF00536.30 EMC80363.1 - 2.3e-15 56.8 0.0 3.9e-15 56.0 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC80363.1 - 9.9e-09 35.2 0.0 2.2e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 EMC80363.1 - 0.0053 16.7 0.0 0.01 15.8 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain VATC PF18716.1 EMC80363.1 - 1.2 9.1 5.5 2.5 8.0 5.5 1.5 1 0 0 1 1 1 0 Vms1-associating treble clef domain zf-FCS PF06467.14 EMC80363.1 - 2.2 8.3 7.0 19 5.3 7.0 2.4 1 1 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif 7tm_1 PF00001.21 EMC80364.1 - 0.092 12.1 20.3 0.38 10.0 20.3 1.8 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Oxidored_q2 PF00420.24 EMC80364.1 - 0.3 10.7 6.5 0.18 11.5 2.2 2.7 2 1 1 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L LRR_8 PF13855.6 EMC80365.1 - 1.2e-59 197.9 28.3 8e-17 60.8 0.9 4.1 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EMC80365.1 - 5.2e-23 80.7 14.6 1.1e-05 25.7 0.1 5.7 2 2 5 7 7 7 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC80365.1 - 3.7e-10 39.6 0.8 0.0034 16.9 0.2 3.1 1 1 1 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 EMC80365.1 - 6.1e-08 32.2 11.5 8.9 7.3 0.0 8.2 8 1 0 8 8 8 2 Leucine Rich Repeat LRR_5 PF13306.6 EMC80365.1 - 1.6e-05 24.8 0.0 0.054 13.4 0.0 2.4 1 1 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRRNT PF01462.18 EMC80365.1 - 0.00052 19.6 1.4 0.0013 18.3 1.4 1.8 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 EMC80365.1 - 5.2 7.4 19.3 46 4.4 0.0 7.3 9 0 0 9 9 9 0 Leucine Rich repeat LRR_8 PF13855.6 EMC80366.1 - 1.2e-70 233.2 101.3 1.5e-14 53.5 4.9 8.3 1 1 8 9 9 9 9 Leucine rich repeat LRR_5 PF13306.6 EMC80366.1 - 3.3e-31 107.9 0.1 1.6e-10 41.0 0.0 3.6 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 EMC80366.1 - 1e-30 105.2 56.1 5e-06 26.8 1.0 9.2 7 1 1 9 9 9 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC80366.1 - 2.2e-14 53.4 27.9 1.5e-05 24.6 3.1 5.8 1 1 4 6 6 6 5 Leucine-rich repeat LRR_1 PF00560.33 EMC80366.1 - 0.15 12.7 0.3 0.15 12.7 0.3 11.1 10 2 1 11 11 11 0 Leucine Rich Repeat CECR6_TMEM121 PF14997.6 EMC80367.1 - 6.8e-61 205.5 12.0 6.8e-61 205.5 12.0 1.4 2 0 0 2 2 2 1 CECR6/TMEM121 family DUF5083 PF16890.5 EMC80367.1 - 0.0088 15.8 1.6 0.0088 15.8 1.6 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF5083) RRP36 PF06102.12 EMC80368.1 - 8.2e-45 152.7 29.9 8.2e-45 152.7 29.9 1.8 2 0 0 2 2 2 1 rRNA biogenesis protein RRP36 Kelch_6 PF13964.6 EMC80368.1 - 3.2e-43 144.7 9.4 3.4e-09 36.7 0.1 6.3 5 1 1 6 6 6 6 Kelch motif Kelch_2 PF07646.15 EMC80368.1 - 5.3e-41 137.1 10.6 5.9e-07 29.2 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.25 EMC80368.1 - 1.8e-38 129.9 7.1 4.8e-08 32.4 0.0 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_5 PF13854.6 EMC80368.1 - 2.2e-33 113.7 11.7 5.9e-06 26.1 0.3 6.4 6 1 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 EMC80368.1 - 7.2e-31 106.0 16.0 1e-07 31.8 0.2 7.2 5 2 1 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 EMC80368.1 - 2.2e-27 94.7 10.6 5.8e-06 26.4 0.2 7.0 7 0 0 7 7 7 5 Galactose oxidase, central domain B56 PF01603.20 EMC80369.1 - 1.3e-193 643.6 6.8 1.5e-193 643.4 6.8 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Pkinase PF00069.25 EMC80370.1 - 9.6e-06 25.1 0.0 0.036 13.4 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Hydrolase_4 PF12146.8 EMC80371.1 - 4e-17 62.3 0.0 1.3e-13 50.8 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMC80371.1 - 7.6e-15 55.2 0.4 8.6e-13 48.5 0.3 2.2 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMC80371.1 - 3.5e-09 37.6 0.5 1.3e-08 35.7 0.5 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 EMC80371.1 - 0.00067 19.6 0.0 0.0014 18.6 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.20 EMC80371.1 - 0.0099 16.0 0.0 0.016 15.4 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Peptidase_S9 PF00326.21 EMC80371.1 - 0.01 15.4 0.0 0.036 13.5 0.0 1.8 1 1 0 1 1 1 0 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EMC80371.1 - 0.037 13.6 0.0 0.045 13.3 0.0 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_2 PF02230.16 EMC80371.1 - 0.058 13.2 0.0 0.26 11.0 0.0 2.0 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Say1_Mug180 PF10340.9 EMC80371.1 - 0.13 11.0 0.0 0.28 10.0 0.0 1.6 1 1 0 1 1 1 0 Steryl acetyl hydrolase Chlorophyllase2 PF12740.7 EMC80371.1 - 0.21 10.5 0.0 1.1 8.0 0.0 1.9 1 1 0 1 1 1 0 Chlorophyllase enzyme Phosphorylase PF00343.20 EMC80372.1 - 0 1139.4 0.0 0 1139.2 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase TPR_22 PF18833.1 EMC80372.1 - 8.6e-05 22.6 0.2 0.00021 21.4 0.2 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat GDA1_CD39 PF01150.17 EMC80373.1 - 2.1e-73 247.4 0.0 1.1e-72 245.0 0.0 1.9 1 1 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.16 EMC80373.1 - 0.14 11.6 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Ppx/GppA phosphatase family Homeodomain PF00046.29 EMC80374.1 - 4.2e-24 84.2 2.8 7.7e-24 83.3 2.8 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC80374.1 - 0.0047 16.8 1.4 0.0087 15.9 0.1 2.1 2 0 0 2 2 2 1 Homeobox KN domain AAA PF00004.29 EMC80375.1 - 8.3e-62 207.5 0.0 8.6e-45 152.4 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EMC80375.1 - 3.6e-09 37.2 1.9 0.012 16.1 0.1 3.7 2 2 1 4 4 4 2 AAA ATPase domain AAA_lid_3 PF17862.1 EMC80375.1 - 9e-09 35.0 0.1 4.6e-05 23.1 0.0 2.5 2 0 0 2 2 2 2 AAA+ lid domain AAA_5 PF07728.14 EMC80375.1 - 2.9e-06 27.3 0.3 0.01 15.8 0.1 3.2 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) TsaE PF02367.17 EMC80375.1 - 9.5e-06 25.6 0.0 0.082 12.9 0.0 3.3 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 EMC80375.1 - 2.9e-05 24.3 0.9 0.018 15.3 0.1 3.6 3 1 0 3 3 3 1 AAA domain Mg_chelatase PF01078.21 EMC80375.1 - 3.7e-05 23.2 3.3 0.016 14.6 0.2 2.6 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 EMC80375.1 - 0.00064 19.5 0.0 0.007 16.1 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EMC80375.1 - 0.00079 19.6 0.0 0.039 14.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EMC80375.1 - 0.00098 19.5 0.0 0.044 14.2 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_2 PF07724.14 EMC80375.1 - 0.0014 18.8 0.0 0.089 12.9 0.0 2.7 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) Vps4_C PF09336.10 EMC80375.1 - 0.0014 18.6 0.0 0.0048 16.9 0.0 2.0 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain Sigma54_activat PF00158.26 EMC80375.1 - 0.0039 16.9 0.0 2.5 7.8 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain TIP49 PF06068.13 EMC80375.1 - 0.004 16.4 0.2 0.049 12.8 0.0 2.1 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_25 PF13481.6 EMC80375.1 - 0.0042 16.7 0.2 0.037 13.6 0.0 2.4 3 0 0 3 3 2 1 AAA domain AAA_7 PF12775.7 EMC80375.1 - 0.0045 16.5 0.0 1.1 8.7 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_19 PF13245.6 EMC80375.1 - 0.0054 17.1 0.0 4.4 7.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 EMC80375.1 - 0.0073 15.5 0.0 0.29 10.3 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 EMC80375.1 - 0.008 15.9 0.3 0.05 13.3 0.1 2.1 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_18 PF13238.6 EMC80375.1 - 0.011 16.3 0.1 0.42 11.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 EMC80375.1 - 0.011 15.5 0.0 1.6 8.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EMC80375.1 - 0.017 14.9 0.9 1.8 8.4 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_3 PF07726.11 EMC80375.1 - 0.025 14.5 0.0 0.83 9.5 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EMC80375.1 - 0.027 14.4 1.1 2.2 8.2 0.2 2.9 2 1 0 2 2 2 0 NACHT domain Rad17 PF03215.15 EMC80375.1 - 0.031 14.2 0.0 6.8 6.6 0.0 2.5 2 0 0 2 2 2 0 Rad17 P-loop domain T2SSE PF00437.20 EMC80375.1 - 0.033 13.3 0.0 2.6 7.0 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_30 PF13604.6 EMC80375.1 - 0.05 13.3 0.3 1.9 8.1 0.2 2.2 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 EMC80375.1 - 0.062 12.4 0.0 0.15 11.1 0.0 1.6 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_24 PF13479.6 EMC80375.1 - 0.08 12.7 0.4 0.23 11.1 0.1 1.8 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 EMC80375.1 - 0.11 12.0 0.4 0.43 10.0 0.2 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_28 PF13521.6 EMC80375.1 - 0.14 12.4 0.0 0.48 10.6 0.0 1.9 2 0 0 2 2 1 0 AAA domain Methyltransf_31 PF13847.6 EMC80376.1 - 1.8e-08 34.3 0.0 3.5e-08 33.4 0.0 1.4 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC80376.1 - 1.2e-07 32.3 0.0 2.5e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC80376.1 - 2.7e-07 31.3 0.0 4.4e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC80376.1 - 2.1e-06 28.3 0.0 3.8e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC80376.1 - 0.00016 21.6 0.0 0.00022 21.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain DUF3456 PF11938.8 EMC80377.1 - 5.6e-44 150.4 3.0 5.6e-44 150.4 3.0 1.8 2 0 0 2 2 2 1 TLR4 regulator and MIR-interacting MSAP PTCRA PF15028.6 EMC80378.1 - 6.5e-20 71.1 0.2 7.6e-20 70.9 0.2 1.0 1 0 0 1 1 1 1 Pre-T-cell antigen receptor C1-set PF07654.15 EMC80378.1 - 0.11 12.9 0.0 0.15 12.5 0.0 1.1 1 0 0 1 1 1 0 Immunoglobulin C1-set domain RNA_pol_Rpb2_6 PF00562.28 EMC80379.1 - 9.2e-105 350.9 0.0 2.8e-104 349.3 0.0 1.7 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_3 PF04565.16 EMC80379.1 - 5.5e-27 93.7 0.0 1.1e-26 92.8 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_1 PF04563.15 EMC80379.1 - 3.5e-23 82.2 0.1 5.7e-23 81.5 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 EMC80379.1 - 5.9e-21 74.7 0.0 1.3e-20 73.6 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpa2_4 PF06883.12 EMC80379.1 - 1.6e-18 66.5 0.0 3.2e-18 65.5 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.14 EMC80379.1 - 2.9e-11 43.4 0.0 4.8e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 PBP_GOBP PF01395.22 EMC80379.1 - 0.2 11.8 1.0 0.42 10.8 1.0 1.5 1 0 0 1 1 1 0 PBP/GOBP family Sugar_tr PF00083.24 EMC80380.1 - 3e-33 115.4 20.0 4e-33 115.0 20.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMC80380.1 - 3e-30 105.3 23.4 4e-30 105.0 23.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 EMC80380.1 - 0.0057 15.3 7.2 0.0057 15.3 7.2 3.6 2 2 1 4 4 4 1 MFS/sugar transport protein TRI12 PF06609.13 EMC80380.1 - 0.23 9.8 9.9 0.028 12.8 5.0 1.7 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) Ig_3 PF13927.6 EMC80381.1 - 1.1e-11 45.1 0.1 6.7e-05 23.4 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 EMC80381.1 - 2.4e-11 43.8 0.3 1.5e-05 25.2 0.1 2.1 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 EMC80381.1 - 5.9e-08 32.8 0.4 0.0023 18.1 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC80381.1 - 7.6e-06 25.9 0.1 0.019 15.0 0.0 3.1 2 1 0 2 2 2 2 Immunoglobulin I-set domain ICAM_N PF03921.14 EMC80381.1 - 2e-05 24.2 0.4 0.00032 20.3 0.0 2.1 2 0 0 2 2 2 1 Intercellular adhesion molecule (ICAM), N-terminal domain V-set PF07686.17 EMC80381.1 - 0.0001 22.4 2.1 0.013 15.7 0.2 2.9 2 2 1 3 3 3 2 Immunoglobulin V-set domain MBT PF02820.18 EMC80382.1 - 8.7e-94 307.9 3.5 1e-33 115.5 0.3 3.4 3 0 0 3 3 3 3 mbt repeat zf-C2HC PF01530.18 EMC80382.1 - 7e-18 64.5 20.8 4.5e-14 52.3 8.8 2.6 2 0 0 2 2 2 2 Zinc finger, C2HC type SAM_1 PF00536.30 EMC80382.1 - 1.7e-12 47.6 0.0 2.9e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) YacG PF03884.14 EMC80382.1 - 0.038 13.7 0.4 0.11 12.2 0.4 1.8 1 0 0 1 1 1 0 DNA gyrase inhibitor YacG SAM_Ste50p PF09235.10 EMC80382.1 - 0.085 13.1 0.1 0.15 12.3 0.1 1.4 1 0 0 1 1 1 0 Ste50p, sterile alpha motif DTHCT PF08070.11 EMC80382.1 - 2.5 8.9 8.9 0.39 11.5 4.2 2.1 2 0 0 2 2 2 0 DTHCT (NUC029) region 4_1_CTD PF05902.13 EMC80384.1 - 1.1e-33 115.5 4.3 1.1e-33 115.5 4.3 3.0 2 1 1 3 3 3 1 4.1 protein C-terminal domain (CTD) SAB PF04382.13 EMC80384.1 - 7.4e-21 74.0 2.3 7.4e-21 74.0 2.3 2.5 2 0 0 2 2 2 1 SAB domain DUF1213 PF06740.12 EMC80384.1 - 0.05 14.2 1.2 0.05 14.2 1.2 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1213) AAR2 PF05282.11 EMC80385.1 - 8.4e-52 176.7 0.2 9.3e-52 176.6 0.2 1.0 1 0 0 1 1 1 1 AAR2 protein Alginate_lyase PF05426.12 EMC80385.1 - 0.034 13.7 0.0 0.049 13.2 0.0 1.2 1 0 0 1 1 1 0 Alginate lyase GKAP PF03359.13 EMC80386.1 - 4.8e-148 493.3 11.6 4.8e-148 493.3 11.6 3.2 4 0 0 4 4 4 1 Guanylate-kinase-associated protein (GKAP) protein Homeobox_KN PF05920.11 EMC80387.1 - 0.0013 18.5 3.1 0.0022 17.9 3.1 1.4 1 0 0 1 1 1 1 Homeobox KN domain EF-hand_1 PF00036.32 EMC80388.1 - 3.8e-16 57.4 8.9 1.2e-07 30.7 1.6 4.4 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 EMC80388.1 - 8.1e-14 51.8 5.8 6.3e-07 29.8 0.2 2.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EMC80388.1 - 2.3e-12 45.8 9.1 7.4e-08 31.7 0.9 3.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 EMC80388.1 - 2.2e-07 30.6 7.4 0.008 16.0 0.1 3.5 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EMC80388.1 - 3.1e-06 26.4 2.9 1.7e-05 24.1 1.5 2.6 2 0 0 2 2 2 1 EF hand EF-hand_11 PF08976.11 EMC80388.1 - 0.00012 22.9 0.1 0.0008 20.3 0.1 1.9 1 1 1 2 2 2 1 EF-hand domain GPHH PF16905.5 EMC80388.1 - 0.0015 18.2 0.0 0.22 11.3 0.0 2.3 2 0 0 2 2 2 1 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_9 PF14658.6 EMC80388.1 - 0.0016 18.7 0.0 2 8.8 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain UPF0154 PF03672.13 EMC80388.1 - 0.0022 17.9 0.0 3.5 7.7 0.0 2.9 3 0 0 3 3 3 2 Uncharacterised protein family (UPF0154) Syntaxin PF00804.25 EMC80388.1 - 0.014 15.0 0.3 0.92 9.1 0.1 2.1 2 0 0 2 2 2 0 Syntaxin SPARC_Ca_bdg PF10591.9 EMC80388.1 - 0.033 14.5 0.6 0.076 13.3 0.1 1.7 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF2267 PF10025.9 EMC80388.1 - 0.063 13.6 0.0 23 5.3 0.0 2.9 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2267) SurA_N_2 PF13623.6 EMC80388.1 - 0.07 13.0 0.1 2.7 7.8 0.0 2.1 2 0 0 2 2 2 0 SurA N-terminal domain Rab5ip PF07019.12 EMC80389.1 - 2.6e-18 66.4 10.3 2.9e-18 66.2 10.3 1.0 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) DUF2244 PF10003.9 EMC80389.1 - 0.022 14.4 0.8 0.022 14.4 0.8 1.9 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) Clc-like PF07062.12 EMC80389.1 - 0.11 12.0 3.5 0.13 11.7 3.5 1.0 1 0 0 1 1 1 0 Clc-like Yip1 PF04893.17 EMC80389.1 - 0.47 10.1 9.3 2.8 7.6 9.0 1.9 1 1 0 1 1 1 0 Yip1 domain Nucleic_acid_bd PF13820.6 EMC80390.1 - 9.3e-52 174.7 0.1 2.7e-51 173.2 0.1 1.9 1 0 0 1 1 1 1 Putative nucleic acid-binding region DOR PF14839.6 EMC80392.1 - 4.9e-26 92.2 6.2 2.1e-24 86.8 1.8 2.6 1 1 1 2 2 2 2 DOR family PIG-U PF06728.13 EMC80393.1 - 5.4e-105 351.6 48.4 6.1e-105 351.4 48.4 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U TLD PF07534.16 EMC80394.1 - 2.2e-35 121.9 0.0 2.5e-35 121.7 0.0 1.0 1 0 0 1 1 1 1 TLD RB_A PF01858.17 EMC80395.1 - 2.6e-80 268.9 0.9 4.2e-79 265.0 0.2 2.5 2 0 0 2 2 2 1 Retinoblastoma-associated protein A domain RB_B PF01857.20 EMC80395.1 - 1.5e-54 183.6 2.3 2.4e-54 182.9 0.5 2.4 2 0 0 2 2 2 1 Retinoblastoma-associated protein B domain DUF3452 PF11934.8 EMC80395.1 - 2.2e-48 163.3 0.3 2.2e-48 163.3 0.3 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3452) Rb_C PF08934.10 EMC80395.1 - 2.5e-06 27.4 1.8 4.4e-06 26.6 0.4 2.1 2 0 0 2 2 2 1 Rb C-terminal domain eIF-3c_N PF05470.12 EMC80395.1 - 0.65 8.2 8.1 1.4 7.1 6.0 2.3 2 1 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus SNF2_N PF00176.23 EMC80396.1 - 5.5e-63 212.8 2.0 9e-63 212.1 2.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.24 EMC80396.1 - 3.7e-25 87.6 3.3 2.8e-13 49.5 0.7 2.9 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 EMC80396.1 - 1.1e-16 61.2 0.0 3.7e-16 59.4 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC80396.1 - 1.8e-07 31.3 0.1 8.2e-07 29.2 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CHDCT2 PF08074.11 EMC80396.1 - 1.8e-05 25.0 0.8 0.37 10.9 0.0 3.7 3 0 0 3 3 3 2 CHDCT2 (NUC038) domain DEAD PF00270.29 EMC80396.1 - 0.00031 20.6 0.0 0.00061 19.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 EMC80396.1 - 0.0064 15.7 0.1 0.037 13.2 0.1 2.2 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 BRK PF07533.16 EMC80396.1 - 0.064 12.9 0.7 0.48 10.1 0.1 2.5 2 0 0 2 2 2 0 BRK domain DUF3437 PF11919.8 EMC80396.1 - 0.12 12.3 0.0 0.4 10.6 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) Collagen PF01391.18 EMC80397.1 - 3.3e-17 62.0 32.0 1.2e-08 34.6 15.2 2.1 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) PID PF00640.23 EMC80398.1 - 1.2e-49 168.0 0.0 2.1e-49 167.2 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH2 PF00017.24 EMC80398.1 - 8.5e-17 61.0 0.0 2.8e-16 59.4 0.0 1.9 2 0 0 2 2 2 1 SH2 domain PTB PF08416.13 EMC80398.1 - 0.024 14.8 0.1 0.29 11.3 0.0 2.4 2 0 0 2 2 2 0 Phosphotyrosine-binding domain Delta_lysin PF05372.11 EMC80398.1 - 0.097 12.0 0.1 0.21 10.9 0.1 1.5 1 0 0 1 1 1 0 Delta lysin family 7tm_1 PF00001.21 EMC80399.1 - 4.5e-40 137.6 23.6 5.7e-40 137.3 23.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC80399.1 - 1.1e-09 38.1 24.7 1.4e-09 37.8 24.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC80399.1 - 0.00013 21.9 21.9 0.0079 16.0 21.9 2.1 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC80399.1 - 0.02 14.5 25.0 0.047 13.3 22.3 2.5 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx Tetraspanin PF00335.20 EMC80399.1 - 2.9 7.5 20.7 0.092 12.4 5.5 2.6 3 0 0 3 3 3 0 Tetraspanin family ODV-E18 PF10717.9 EMC80399.1 - 7.3 6.5 6.3 2.1 8.3 2.3 2.1 1 1 1 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 Thioredoxin_8 PF13905.6 EMC80400.1 - 3.9e-30 104.0 0.0 5.3e-30 103.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 EMC80400.1 - 8.7e-08 32.1 0.1 0.00037 20.4 0.0 2.1 2 0 0 2 2 2 2 Thioredoxin Redoxin PF08534.10 EMC80400.1 - 4.2e-07 29.8 0.0 5.3e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EMC80400.1 - 0.00083 19.3 0.0 0.0012 18.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_2 PF13098.6 EMC80400.1 - 0.06 13.8 0.0 0.11 13.0 0.0 1.4 1 1 0 1 1 1 0 Thioredoxin-like domain NAD_synthase PF02540.17 EMC80400.1 - 0.19 10.8 0.0 0.26 10.4 0.0 1.1 1 0 0 1 1 1 0 NAD synthase Spin-Ssty PF02513.17 EMC80401.1 - 1.6e-76 251.8 7.8 7.2e-28 96.1 0.2 3.2 3 0 0 3 3 3 3 Spin/Ssty Family MFS_1 PF07690.16 EMC80402.1 - 1.2e-34 119.8 37.9 1.6e-33 116.1 36.4 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EMC80402.1 - 2.6e-12 46.3 23.5 5.2e-10 38.7 21.8 3.8 2 1 0 2 2 2 1 MFS_1 like family US10 PF17617.2 EMC80402.1 - 0.042 13.9 0.1 0.077 13.1 0.1 1.5 1 0 0 1 1 1 0 Viral unique short region 10 Myosin_tail_1 PF01576.19 EMC80403.1 - 2.7e-108 363.3 173.5 3.2e-108 363.0 173.5 1.0 1 0 0 1 1 1 1 Myosin tail DUF1664 PF07889.12 EMC80403.1 - 1.1e-06 28.7 103.9 0.00067 19.7 7.4 9.7 2 1 7 10 10 10 4 Protein of unknown function (DUF1664) Filament PF00038.21 EMC80403.1 - 9.8e-05 22.1 154.2 0.19 11.3 44.9 5.8 1 1 4 5 5 5 4 Intermediate filament protein TSNAXIP1_N PF15739.5 EMC80403.1 - 0.0017 18.7 8.5 0.0017 18.7 8.5 11.2 2 2 9 11 11 8 2 Translin-associated factor X-interacting N-terminus Spc7 PF08317.11 EMC80403.1 - 0.0043 16.0 23.9 0.0043 16.0 23.9 7.2 1 1 6 7 7 7 2 Spc7 kinetochore protein BBP1_C PF15272.6 EMC80403.1 - 0.0045 16.8 15.8 0.0045 16.8 15.8 7.3 1 1 5 6 6 5 1 Spindle pole body component BBP1, C-terminal Syntaxin-6_N PF09177.11 EMC80403.1 - 0.0066 17.0 7.7 0.0066 17.0 7.7 10.4 3 3 5 8 8 7 1 Syntaxin 6, N-terminal BRE1 PF08647.11 EMC80403.1 - 0.0076 16.3 11.2 0.0076 16.3 11.2 10.7 1 1 8 11 11 10 4 BRE1 E3 ubiquitin ligase Bacillus_HBL PF05791.11 EMC80403.1 - 0.016 15.1 90.3 0.064 13.1 7.7 8.9 2 2 6 9 9 9 0 Bacillus haemolytic enterotoxin (HBL) TPR_MLP1_2 PF07926.12 EMC80403.1 - 0.089 12.9 180.4 0.45 10.6 9.4 9.0 2 2 5 8 8 8 0 TPR/MLP1/MLP2-like protein ATG16 PF08614.11 EMC80403.1 - 0.21 11.8 170.9 0.17 12.1 19.7 7.7 1 1 6 7 7 7 0 Autophagy protein 16 (ATG16) zf-C2HE PF16278.5 EMC80403.1 - 0.54 10.8 5.5 0.99 9.9 0.3 4.5 2 2 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Fib_alpha PF08702.10 EMC80403.1 - 0.6 10.3 112.8 0.15 12.3 13.4 7.8 1 1 6 7 7 7 0 Fibrinogen alpha/beta chain family PDZ PF00595.24 EMC80404.1 - 2.9e-08 33.9 0.4 4.4e-08 33.4 0.4 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 EMC80405.1 - 3.8e-18 65.6 0.4 5.7e-18 65.0 0.4 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC80405.1 - 1.8e-09 37.3 0.2 2.7e-09 36.7 0.2 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC80405.1 - 0.00019 21.7 0.1 0.00037 20.7 0.0 1.7 2 0 0 2 2 2 1 PDZ domain Sec61_beta PF03911.16 EMC80405.1 - 0.29 11.2 1.0 0.75 9.9 0.2 1.9 2 0 0 2 2 2 0 Sec61beta family GPP34 PF05719.11 EMC80406.1 - 1.1e-53 182.3 0.3 1.3e-53 182.1 0.3 1.0 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) Peptidase_M15_2 PF05951.13 EMC80406.1 - 0.025 14.3 0.1 0.044 13.5 0.1 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF882) Myotub-related PF06602.14 EMC80407.1 - 2.3e-49 168.2 7.5 2.5e-48 164.8 4.3 2.2 1 1 1 2 2 2 2 Myotubularin-like phosphatase domain 3-PAP PF12578.8 EMC80407.1 - 3.4e-39 133.6 0.0 6.7e-39 132.6 0.0 1.5 1 0 0 1 1 1 1 Myotubularin-associated protein PC4 PF02229.16 EMC80408.1 - 1.3e-25 88.7 0.4 2.1e-25 88.1 0.4 1.4 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) QLQ PF08880.11 EMC80408.1 - 0.024 14.4 0.2 0.035 13.9 0.2 1.2 1 0 0 1 1 1 0 QLQ ANF_receptor PF01094.28 EMC80409.1 - 1.1e-32 113.6 0.2 1.3e-32 113.3 0.2 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region DUF4690 PF15756.5 EMC80409.1 - 0.069 13.8 0.0 0.14 12.8 0.0 1.4 1 0 0 1 1 1 0 Small Novel Rich in Cartilage tRNA-synt_2b PF00587.25 EMC80410.1 - 3.8e-36 124.7 0.0 8.5e-36 123.6 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EMC80410.1 - 1.8e-20 72.8 0.1 4e-20 71.8 0.1 1.6 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.21 EMC80410.1 - 2.9e-18 65.7 0.1 2.9e-17 62.4 0.0 2.3 2 0 0 2 2 2 1 TGS domain tRNA_SAD PF07973.14 EMC80410.1 - 1.6e-12 47.3 0.1 3.8e-12 46.1 0.1 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain START PF01852.19 EMC80412.1 - 6e-43 146.7 0.3 1.1e-42 145.9 0.3 1.3 1 0 0 1 1 1 1 START domain RhoGAP PF00620.27 EMC80412.1 - 2.2e-36 125.0 0.7 4.4e-36 124.0 0.7 1.5 1 0 0 1 1 1 1 RhoGAP domain SAM_2 PF07647.17 EMC80412.1 - 0.0014 18.7 0.5 0.0052 16.9 0.0 2.3 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) Glyco_hydro_1 PF00232.18 EMC80413.1 - 5.2e-166 552.6 16.4 1.4e-76 257.8 6.4 4.0 2 2 1 3 3 3 3 Glycosyl hydrolase family 1 HEAT PF02985.22 EMC80415.1 - 0.0063 16.7 2.5 2.2 8.8 0.0 5.3 5 0 0 5 5 5 1 HEAT repeat Cnd1 PF12717.7 EMC80415.1 - 0.02 15.0 16.5 0.37 10.8 0.4 5.8 4 2 2 6 6 6 0 non-SMC mitotic condensation complex subunit 1 PI-TkoII_IV PF18714.1 EMC80415.1 - 0.068 12.6 0.0 0.22 11.0 0.0 1.8 1 0 0 1 1 1 0 DNA polymerase II intein Domain IV FANCI_S2 PF14676.6 EMC80415.1 - 0.24 11.7 1.9 4.5 7.5 0.3 3.4 2 1 0 2 2 2 0 FANCI solenoid 2 AAA_33 PF13671.6 EMC80416.1 - 5.8e-15 55.7 0.0 1.1e-14 54.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EMC80416.1 - 1.2e-05 24.7 0.0 3.1e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.6 EMC80416.1 - 0.00036 21.1 0.1 0.0012 19.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.10 EMC80416.1 - 0.0013 18.3 0.1 0.0034 16.9 0.0 1.7 2 0 0 2 2 2 1 Chromatin associated protein KTI12 ABC_tran PF00005.27 EMC80416.1 - 0.0054 17.2 0.3 0.022 15.3 0.0 2.1 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 EMC80416.1 - 0.023 15.1 0.0 0.044 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.6 EMC80416.1 - 0.029 14.8 0.1 0.093 13.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EMC80416.1 - 0.096 13.0 0.0 0.37 11.1 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EMC80418.1 - 6.6e-10 39.3 0.2 1e-09 38.7 0.2 1.3 1 0 0 1 1 1 1 AAA domain BRCA-2_helical PF09169.10 EMC80419.1 - 2.2e-93 311.2 0.1 1.2e-92 308.8 0.0 2.5 2 0 0 2 2 2 1 BRCA2, helical BRCA2 PF00634.18 EMC80419.1 - 2.5e-54 180.6 31.4 5.6e-12 45.1 0.5 7.7 7 0 0 7 7 7 6 BRCA2 repeat BRCA-2_OB3 PF09104.10 EMC80419.1 - 1.8e-52 176.7 0.9 4.5e-52 175.4 0.1 2.3 2 0 0 2 2 2 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 BRCA-2_OB1 PF09103.10 EMC80419.1 - 7.2e-41 139.0 0.2 3e-40 137.0 0.0 2.3 2 0 0 2 2 2 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 Tower PF09121.10 EMC80419.1 - 1.6e-21 76.2 4.0 4.8e-21 74.7 4.0 1.9 1 0 0 1 1 1 1 Tower DUF45 PF01863.17 EMC80419.1 - 0.99 9.4 6.0 2.4 8.1 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function DUF45 zf-3CxxC PF13695.6 EMC80420.1 - 3.8e-09 36.9 17.5 6.1e-09 36.3 17.5 1.3 1 0 0 1 1 1 1 Zinc-binding domain zf-3CxxC_2 PF17180.4 EMC80420.1 - 0.00043 20.9 23.7 0.00043 20.9 23.7 2.3 2 1 0 2 2 2 1 Zinc-binding domain RNA_pol_Rpb1_1 PF04997.12 EMC80420.1 - 0.29 10.4 4.2 0.58 9.4 4.2 1.6 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 1 MOR2-PAG1_N PF14222.6 EMC80421.1 - 7.8e-169 563.2 4.6 1.7e-168 562.0 4.6 1.6 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 EMC80421.1 - 4.5e-72 243.0 9.6 4.5e-72 243.0 9.6 3.3 3 0 0 3 3 3 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 EMC80421.1 - 2.1e-27 95.3 7.0 3.6e-09 34.9 0.0 6.2 5 1 2 7 7 7 5 Cell morphogenesis central region MAPEG PF01124.18 EMC80422.1 - 2.3e-08 34.0 0.3 2.8e-08 33.7 0.3 1.2 1 0 0 1 1 1 1 MAPEG family Ndr PF03096.14 EMC80422.1 - 0.049 12.3 0.0 0.062 12.0 0.0 1.1 1 0 0 1 1 1 0 Ndr family DUF4650 PF15509.6 EMC80423.1 - 1.3e-146 490.0 35.1 1e-125 421.1 25.8 2.5 2 1 1 3 3 3 2 Domain of unknown function (DUF4650) Peptidase_C98 PF15499.6 EMC80423.1 - 5.5e-126 419.6 10.3 1.1e-125 418.6 10.3 1.6 1 0 0 1 1 1 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase GHL5 PF14872.6 EMC80423.1 - 0.037 12.1 0.0 0.055 11.5 0.0 1.1 1 0 0 1 1 1 0 Hypothetical glycoside hydrolase 5 HMG_box_2 PF09011.10 EMC80424.1 - 2.5e-40 136.9 12.0 9.3e-27 93.4 7.4 2.7 3 0 0 3 3 3 2 HMG-box domain HMG_box PF00505.19 EMC80424.1 - 2.8e-40 136.6 12.2 1.9e-25 89.0 0.4 3.0 3 0 0 3 3 3 2 HMG (high mobility group) box FAA_hydrolase_N PF09298.11 EMC80424.1 - 0.05 13.8 0.2 0.085 13.1 0.2 1.3 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal Rrn6 PF10214.9 EMC80424.1 - 1.1 7.6 13.4 0.18 10.3 5.9 1.8 1 1 1 2 2 2 0 RNA polymerase I-specific transcription-initiation factor AAA PF00004.29 EMC80425.1 - 7e-40 136.5 0.0 1.6e-39 135.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMC80425.1 - 6.4e-14 51.5 2.5 1.5e-13 50.3 0.4 2.8 2 1 0 2 2 1 1 AAA+ lid domain Vps4_C PF09336.10 EMC80425.1 - 2.4e-10 40.2 0.2 2.3e-09 37.1 0.0 2.7 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.12 EMC80425.1 - 1.5e-05 24.8 0.0 2.7e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EMC80425.1 - 2.3e-05 24.6 0.0 4.6e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EMC80425.1 - 2.9e-05 24.3 0.0 5.1e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EMC80425.1 - 4.4e-05 23.9 0.1 0.029 14.8 0.1 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EMC80425.1 - 0.00019 21.4 0.3 0.0016 18.4 0.2 2.6 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EMC80425.1 - 0.0003 20.1 0.0 0.00051 19.4 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 EMC80425.1 - 0.00075 18.9 0.2 0.0016 17.8 0.2 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 EMC80425.1 - 0.0014 18.6 0.0 0.0029 17.6 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EMC80425.1 - 0.0026 17.8 0.0 0.0066 16.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EMC80425.1 - 0.0034 17.1 0.0 0.0072 16.1 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_22 PF13401.6 EMC80425.1 - 0.0051 17.1 0.6 0.076 13.3 0.2 2.7 2 1 1 3 3 3 1 AAA domain AAA_18 PF13238.6 EMC80425.1 - 0.0052 17.3 0.3 0.023 15.2 0.3 2.1 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EMC80425.1 - 0.0081 15.7 0.3 0.019 14.5 0.2 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_24 PF13479.6 EMC80425.1 - 0.012 15.3 0.1 0.34 10.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EMC80425.1 - 0.03 13.7 0.2 2.5 7.4 0.1 2.4 1 1 1 2 2 2 0 KaiC TPR_8 PF13181.6 EMC80425.1 - 0.037 14.2 1.5 3.1 8.2 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat NACHT PF05729.12 EMC80425.1 - 0.046 13.6 0.1 0.12 12.3 0.1 1.7 1 0 0 1 1 1 0 NACHT domain PhoH PF02562.16 EMC80425.1 - 0.052 13.0 0.1 0.1 12.1 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_28 PF13521.6 EMC80425.1 - 0.053 13.8 0.1 0.12 12.6 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EMC80425.1 - 0.061 13.8 0.0 0.22 11.9 0.0 2.0 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EMC80425.1 - 0.071 13.5 0.0 0.17 12.3 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Guanylate_kin PF00625.21 EMC80425.1 - 0.14 11.9 0.0 0.49 10.1 0.0 1.9 2 0 0 2 2 2 0 Guanylate kinase AAA_30 PF13604.6 EMC80425.1 - 0.15 11.7 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EMC80425.1 - 0.16 11.5 0.3 0.54 9.8 0.3 1.9 1 1 1 2 2 2 0 AAA domain TPR_2 PF07719.17 EMC80425.1 - 0.57 10.4 1.7 35 4.8 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Rad60-SLD_2 PF13881.6 EMC80426.1 - 9.4e-33 112.6 0.0 1.1e-32 112.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EMC80426.1 - 8.7e-05 22.2 0.0 0.00019 21.1 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 EMC80426.1 - 0.044 14.3 0.0 0.058 13.9 0.0 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Met_gamma_lyase PF06838.11 EMC80426.1 - 0.076 11.5 0.0 0.096 11.2 0.0 1.1 1 0 0 1 1 1 0 Methionine gamma-lyase AA_permease_2 PF13520.6 EMC80427.1 - 9.9e-54 182.8 26.4 9.9e-54 182.8 26.4 2.2 2 0 0 2 2 2 1 Amino acid permease AA_permease PF00324.21 EMC80427.1 - 1.1e-40 139.7 25.9 1.1e-40 139.7 25.9 2.4 2 1 0 2 2 2 1 Amino acid permease AA_permease_C PF13906.6 EMC80427.1 - 3e-25 88.1 9.9 3e-25 88.1 9.9 3.9 5 0 0 5 5 5 1 C-terminus of AA_permease DUF3278 PF11683.8 EMC80427.1 - 1.2 9.3 11.6 0.2 11.7 0.3 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF3278) RTBV_P46 PF06216.11 EMC80428.1 - 0.23 10.3 8.8 0.082 11.8 3.0 2.1 1 1 0 2 2 2 0 Rice tungro bacilliform virus P46 protein NPV_P10 PF05531.12 EMC80428.1 - 2.1 8.9 22.0 0.74 10.3 3.5 4.8 3 2 1 4 4 4 0 Nucleopolyhedrovirus P10 protein MFS_1 PF07690.16 EMC80429.1 - 1e-15 57.6 28.8 1e-15 57.6 28.8 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily UMP1 PF05348.11 EMC80430.1 - 3.7e-37 127.1 0.1 4.6e-37 126.8 0.1 1.0 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 Pkinase_Tyr PF07714.17 EMC80431.1 - 3.4e-106 354.3 0.0 5.6e-106 353.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.6 EMC80431.1 - 1.5e-57 192.1 5.8 1.1e-13 51.6 0.0 7.1 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.16 EMC80431.1 - 6.6e-54 180.0 7.1 1.9e-16 59.9 0.0 7.1 6 1 0 6 6 6 6 Immunoglobulin I-set domain Pkinase PF00069.25 EMC80431.1 - 5.1e-44 150.6 0.0 2.3e-30 105.8 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Ig_2 PF13895.6 EMC80431.1 - 4.4e-37 126.3 14.6 4.6e-10 39.7 0.0 8.2 7 1 0 7 7 7 6 Immunoglobulin domain ig PF00047.25 EMC80431.1 - 8.1e-36 122.1 10.2 9.5e-08 32.1 0.0 7.9 7 1 0 7 7 7 5 Immunoglobulin domain VEGFR-2_TMD PF17988.1 EMC80431.1 - 2e-17 62.3 0.4 4.5e-17 61.2 0.4 1.6 1 0 0 1 1 1 1 VEGFR-2 Transmembrane domain V-set PF07686.17 EMC80431.1 - 1e-14 54.6 17.2 0.0026 17.9 0.0 8.9 6 3 0 6 6 6 3 Immunoglobulin V-set domain C1-set PF07654.15 EMC80431.1 - 3.7e-09 36.8 3.0 0.18 12.2 0.0 5.2 5 0 0 5 5 5 3 Immunoglobulin C1-set domain Ig_6 PF18452.1 EMC80431.1 - 1.7e-08 33.9 1.2 0.52 9.9 0.0 6.3 6 0 0 6 6 6 2 Immunoglobulin domain Ig_4 PF16680.5 EMC80431.1 - 2.2e-08 34.2 3.2 0.048 13.9 0.0 5.7 5 0 0 5 5 5 2 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 EMC80431.1 - 1.4e-07 31.5 3.6 17 5.5 0.0 6.5 6 0 0 6 6 6 0 Izumo-like Immunoglobulin domain C2-set_2 PF08205.12 EMC80431.1 - 0.00071 19.6 0.3 6.2 7.0 0.0 3.9 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Haspin_kinase PF12330.8 EMC80431.1 - 0.021 13.7 0.0 0.045 12.7 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Herpes_gE PF02480.16 EMC80431.1 - 0.053 12.3 0.1 0.34 9.6 0.0 2.4 4 0 0 4 4 4 0 Alphaherpesvirus glycoprotein E Adeno_E3_CR1 PF02440.15 EMC80431.1 - 1.3 8.9 6.8 33 4.3 0.0 4.7 4 1 0 4 4 4 0 Adenovirus E3 region protein CR1 Pan3_PK PF18101.1 EMC80432.1 - 1.4e-62 209.8 0.0 2.2e-62 209.1 0.0 1.3 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 EMC80432.1 - 0.0014 18.0 0.0 0.0044 16.4 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC80433.1 - 6.2e-103 343.6 0.0 8.6e-103 343.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC80433.1 - 2.2e-45 155.1 0.0 7.9e-29 100.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.6 EMC80433.1 - 1.5e-07 31.9 9.7 0.61 10.7 0.0 5.6 6 0 0 6 6 6 3 Immunoglobulin domain ig PF00047.25 EMC80433.1 - 1.8e-06 28.0 0.2 0.0035 17.5 0.0 4.0 4 0 0 4 4 4 1 Immunoglobulin domain Haspin_kinase PF12330.8 EMC80433.1 - 0.0013 17.7 0.1 0.0027 16.7 0.1 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Ig_2 PF13895.6 EMC80433.1 - 0.0042 17.4 6.3 0.098 13.0 0.0 3.8 4 0 0 4 4 4 1 Immunoglobulin domain Ost5 PF05251.12 EMC80433.1 - 0.02 15.1 0.6 0.05 13.9 0.6 1.6 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit 5 APH PF01636.23 EMC80433.1 - 0.054 13.4 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIFIN PF02009.16 EMC80433.1 - 0.1 12.5 0.0 0.34 10.7 0.0 1.8 2 0 0 2 2 2 0 Rifin Homeodomain PF00046.29 EMC80434.1 - 2.7e-22 78.4 6.3 4.2e-22 77.8 6.3 1.3 1 0 0 1 1 1 1 Homeodomain U62_UL91 PF17442.2 EMC80434.1 - 0.2 11.7 0.2 0.68 10.0 0.0 1.7 1 1 1 2 2 2 0 Functional domain of U62 and UL91 proteins Homeodomain PF00046.29 EMC80435.1 - 1.5e-22 79.1 4.6 2.2e-22 78.6 4.6 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC80435.1 - 0.027 14.3 0.2 0.053 13.4 0.2 1.5 1 0 0 1 1 1 0 Homeobox KN domain Terminase_5 PF06056.12 EMC80435.1 - 0.032 14.1 0.0 0.052 13.5 0.0 1.3 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) HTH_23 PF13384.6 EMC80435.1 - 0.12 12.3 0.1 0.21 11.4 0.1 1.4 1 0 0 1 1 1 0 Homeodomain-like domain WDCP PF15390.6 EMC80436.1 - 0.87 7.9 4.0 0.78 8.0 4.0 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family IF3_N PF05198.16 EMC80437.1 - 3.6e-16 59.2 0.1 1.6e-15 57.1 0.0 2.1 2 0 0 2 2 2 1 Translation initiation factor IF-3, N-terminal domain IF3_C PF00707.22 EMC80437.1 - 2e-08 34.1 0.5 6.8e-08 32.4 0.5 2.0 1 1 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain HTH_33 PF13592.6 EMC80437.1 - 0.029 14.0 0.1 0.077 12.6 0.1 1.7 1 0 0 1 1 1 0 Winged helix-turn helix DM4_12 PF07841.13 EMC80437.1 - 0.19 12.4 2.3 0.24 12.1 0.3 2.3 3 1 0 3 3 3 0 DM4/DM12 family zf-C2H2 PF00096.26 EMC80438.1 - 1.1e-31 107.5 54.9 8e-05 22.9 2.6 8.3 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC80438.1 - 3.7e-16 58.4 50.6 0.0098 16.7 1.3 8.5 8 1 0 8 8 8 6 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC80438.1 - 2.1e-15 56.4 57.1 0.00036 20.8 0.5 9.2 9 0 0 9 9 9 7 Zinc-finger double domain zf-C2H2_8 PF15909.5 EMC80438.1 - 9.6e-06 25.8 25.4 0.15 12.3 1.4 4.2 1 1 3 4 4 4 3 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 EMC80438.1 - 5.1e-05 23.4 24.3 0.42 10.9 1.4 6.9 7 0 0 7 7 7 3 Zinc-finger double-stranded RNA-binding CHORD PF04968.12 EMC80438.1 - 0.0015 19.2 37.0 0.87 10.4 0.3 6.8 2 2 4 7 7 7 4 CHORD zf-C2H2_11 PF16622.5 EMC80438.1 - 0.0036 17.0 8.2 0.65 9.8 0.1 4.6 4 0 0 4 4 4 1 zinc-finger C2H2-type zf-met PF12874.7 EMC80438.1 - 0.0049 17.2 22.1 3.7 8.1 1.1 7.2 7 0 0 7 7 7 1 Zinc-finger of C2H2 type zf-Di19 PF05605.12 EMC80438.1 - 0.0058 16.9 22.6 0.19 12.1 4.3 5.0 2 2 2 4 4 4 3 Drought induced 19 protein (Di19), zinc-binding zf_C2H2_ZHX PF18387.1 EMC80438.1 - 0.02 14.5 0.6 0.02 14.5 0.6 4.4 3 1 3 6 6 6 0 Zinc-fingers and homeoboxes C2H2 finger domain FOXP-CC PF16159.5 EMC80438.1 - 0.025 15.2 26.5 0.62 10.7 0.0 5.9 2 2 5 7 7 7 0 FOXP coiled-coil domain zf_Hakai PF18408.1 EMC80438.1 - 0.037 13.7 0.0 0.037 13.7 0.0 6.3 6 1 1 7 7 7 0 C2H2 Hakai zinc finger domain UME PF08064.13 EMC80438.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 UME (NUC010) domain Ogr_Delta PF04606.12 EMC80438.1 - 1.1 9.2 0.1 1.1 9.2 0.1 6.5 5 2 2 7 7 7 0 Ogr/Delta-like zinc finger zf-C2HC_2 PF13913.6 EMC80438.1 - 6.1 6.9 19.7 2.5 8.1 0.3 6.5 7 0 0 7 7 7 0 zinc-finger of a C2HC-type Ras PF00071.22 EMC80439.1 - 1.9e-31 108.9 0.0 2.3e-31 108.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC80439.1 - 2.3e-09 37.5 0.0 3.5e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EMC80439.1 - 1.7e-06 28.1 0.0 2.7e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EMC80439.1 - 0.0015 17.9 0.0 0.002 17.5 0.0 1.3 1 0 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 EMC80439.1 - 0.0054 16.7 0.1 2.3 8.1 0.0 2.5 2 1 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EMC80439.1 - 0.038 14.4 0.0 0.061 13.7 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AlkA_N PF06029.11 EMC80439.1 - 0.041 14.1 0.0 0.1 12.9 0.0 1.8 1 1 0 1 1 1 0 AlkA N-terminal domain AAA_22 PF13401.6 EMC80439.1 - 0.13 12.5 0.0 0.27 11.5 0.0 1.6 1 1 1 2 2 2 0 AAA domain Ribosomal_L21e PF01157.18 EMC80440.1 - 7.5e-49 163.8 6.5 7.5e-49 163.8 6.5 1.5 2 0 0 2 2 2 1 Ribosomal protein L21e Nudix_hydro PF18290.1 EMC80440.1 - 0.0056 16.6 0.2 0.0087 16.0 0.2 1.3 1 0 0 1 1 1 1 Nudix hydrolase domain CLP_protease PF00574.23 EMC80440.1 - 0.042 13.7 0.1 0.06 13.2 0.1 1.2 1 0 0 1 1 1 0 Clp protease UCH PF00443.29 EMC80441.1 - 4.9e-61 206.5 1.8 5.7e-61 206.2 1.8 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMC80441.1 - 2.1e-31 109.7 2.8 2.9e-31 109.3 2.8 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 EMC80441.1 - 0.0018 17.8 9.9 0.0032 17.0 7.1 2.4 2 1 0 2 2 2 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase CEBP_ZZ PF16366.5 EMC80441.1 - 0.59 10.4 6.5 0.51 10.6 1.7 2.4 2 0 0 2 2 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain RVT_1 PF00078.27 EMC80442.1 - 0.0063 16.1 0.0 0.0093 15.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) 7tm_1 PF00001.21 EMC80443.1 - 1.1e-35 123.3 20.8 1.3e-35 123.0 20.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC80443.1 - 1.1e-05 24.9 11.6 1.1e-05 24.9 11.6 2.0 1 1 1 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC80443.1 - 3.6e-05 23.6 18.8 0.00017 21.4 18.8 2.4 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC80443.1 - 0.53 9.9 24.3 0.041 13.5 16.4 2.5 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx Pkinase PF00069.25 EMC80444.1 - 8.7e-56 189.2 0.1 1.1e-55 188.9 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC80444.1 - 3.8e-20 72.3 0.0 6.1e-20 71.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EMC80444.1 - 0.0063 16.5 0.1 0.0098 15.8 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EMC80444.1 - 0.013 14.8 0.1 0.028 13.8 0.1 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RING_2 PF13639.6 EMC80445.1 - 6.5e-13 48.8 8.2 1e-12 48.2 8.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EMC80445.1 - 8.3e-10 38.8 7.2 1.7e-09 37.8 7.2 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EMC80445.1 - 3.7e-08 33.1 6.9 5.8e-08 32.5 6.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EMC80445.1 - 1.6e-07 31.0 5.2 1.6e-07 31.0 5.2 1.8 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 EMC80445.1 - 2.5e-07 30.4 7.8 4.2e-07 29.7 7.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EMC80445.1 - 1.2e-05 25.3 1.7 2.5e-05 24.2 1.7 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EMC80445.1 - 7e-05 22.6 4.7 0.00011 22.0 4.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC80445.1 - 9.2e-05 22.3 6.5 0.00015 21.6 6.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC80445.1 - 0.0039 17.0 5.5 0.0075 16.1 5.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EMC80445.1 - 0.0046 16.9 1.6 0.0046 16.9 1.6 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.6 EMC80445.1 - 0.05 13.4 4.6 0.086 12.6 4.6 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 EMC80445.1 - 0.19 11.3 5.5 0.32 10.7 5.5 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 EMC80445.1 - 0.39 11.1 6.2 0.7 10.2 6.2 1.4 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.8 EMC80445.1 - 1.6 8.9 6.9 7.4 6.8 6.9 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 EMC80445.1 - 2.6 8.2 7.1 5.9 7.1 7.0 1.6 1 1 0 1 1 1 0 RING-variant domain PhoLip_ATPase_C PF16212.5 EMC80446.1 - 8e-79 264.9 19.0 8e-79 264.9 19.0 2.2 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EMC80446.1 - 1.9e-19 69.1 0.8 1.9e-19 69.1 0.8 1.9 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EMC80446.1 - 1.8e-14 53.6 0.0 6.4e-13 48.6 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EMC80446.1 - 2.8e-12 46.5 0.0 1.1e-11 44.5 0.0 2.0 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EMC80446.1 - 9.8e-08 32.5 0.0 0.002 18.4 0.0 3.2 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Colicin_im PF03857.13 EMC80446.1 - 0.0025 17.8 0.2 0.0025 17.8 0.2 2.7 2 0 0 2 2 2 1 Colicin immunity protein Hydrolase_3 PF08282.12 EMC80446.1 - 0.013 15.3 0.4 0.044 13.5 0.2 1.9 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Shisa PF13908.6 EMC80447.1 - 1.3e-22 81.0 2.1 1.3e-22 81.0 2.1 1.6 1 1 0 1 1 1 1 Wnt and FGF inhibitory regulator Gag_MA PF01140.19 EMC80447.1 - 0.051 13.3 1.4 0.073 12.8 0.3 1.6 1 1 1 2 2 2 0 Matrix protein (MA), p15 Rhabdo_glycop PF00974.18 EMC80447.1 - 0.098 11.1 0.1 0.14 10.6 0.1 1.1 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein Nucleoporin_FG2 PF15967.5 EMC80448.1 - 0 1023.9 57.3 0 1023.7 57.3 1.0 1 0 0 1 1 1 1 Nucleoporin FG repeated region FapA PF03961.13 EMC80448.1 - 0.0074 14.9 5.9 0.055 12.1 0.3 2.1 2 0 0 2 2 2 2 Flagellar Assembly Protein A Tox-ODYAM1 PF15642.6 EMC80448.1 - 0.024 13.6 6.5 0.033 13.2 6.5 1.1 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus PSY3 PF16836.5 EMC80448.1 - 0.23 10.9 2.8 0.13 11.8 0.3 1.7 2 0 0 2 2 2 0 Shu complex component Psy3, DNA-binding description DUF1043 PF06295.12 EMC80448.1 - 0.31 11.0 9.0 2.6 8.1 1.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) DUF1664 PF07889.12 EMC80448.1 - 0.37 10.8 7.4 1.9 8.6 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) RNase_3_N PF18497.1 EMC80448.1 - 1.3 9.3 4.8 15 5.9 0.4 2.3 2 0 0 2 2 2 0 Ribonuclease III N-terminal domain COG2 PF06148.11 EMC80448.1 - 2.2 8.4 8.2 3.1 7.9 1.1 2.9 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 PHM7_cyt PF14703.6 EMC80448.1 - 2.4 8.4 10.8 1.8 8.8 7.3 2.3 2 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter CENP-F_leu_zip PF10473.9 EMC80448.1 - 2.4 8.2 14.5 2.4 8.2 0.5 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Golgin_A5 PF09787.9 EMC80448.1 - 3.8 6.9 16.2 1.3 8.4 6.2 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 Fib_alpha PF08702.10 EMC80448.1 - 4.8 7.4 12.5 3.2 7.9 1.2 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Myotub-related PF06602.14 EMC80449.1 - 2.8e-143 477.1 0.2 4e-143 476.6 0.2 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DSPc PF00782.20 EMC80449.1 - 0.0031 17.3 0.2 0.033 14.0 0.0 2.4 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC80449.1 - 0.0049 16.5 0.0 0.016 14.8 0.0 1.8 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EMC80449.1 - 0.023 14.7 0.0 0.047 13.7 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF2353 PF09789.9 EMC80449.1 - 0.059 12.7 0.1 0.095 12.0 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) WTX PF09422.10 EMC80450.1 - 1.7e-116 390.1 15.0 2.4e-116 389.6 15.0 1.2 1 0 0 1 1 1 1 WTX protein RhoGEF PF00621.20 EMC80451.1 - 9.6e-46 156.3 5.7 9.6e-46 156.3 5.7 1.9 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 EMC80451.1 - 4.3e-11 43.2 0.8 9.9e-11 42.1 0.8 1.6 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.28 EMC80451.1 - 2.4e-10 39.9 2.1 5.5e-10 38.7 2.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC80451.1 - 5.8e-10 38.9 0.1 1.1e-09 38.0 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC80451.1 - 1.1e-07 31.4 0.0 2.5e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain PH_5 PF15405.6 EMC80451.1 - 0.0051 16.9 0.4 0.063 13.4 0.5 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain Myosin_TH1 PF06017.13 EMC80451.1 - 0.0054 16.4 1.3 0.01 15.5 1.3 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding C1q PF00386.21 EMC80452.1 - 8.3e-39 132.7 0.0 1.1e-38 132.4 0.0 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 EMC80452.1 - 9.4e-30 102.2 82.6 8.4e-11 41.5 25.6 3.7 1 1 2 3 3 3 3 Collagen triple helix repeat (20 copies) BclA_C PF18573.1 EMC80452.1 - 1.2e-06 28.4 0.0 1.8e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 BclA C-terminal domain Peptidase_M3 PF01432.20 EMC80453.1 - 9.3e-145 483.4 0.0 1.3e-144 482.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 VKG_Carbox PF05090.14 EMC80453.1 - 0.031 13.1 0.1 0.047 12.5 0.1 1.2 1 0 0 1 1 1 0 Vitamin K-dependent gamma-carboxylase Peptidase_M91 PF14891.6 EMC80453.1 - 0.042 14.2 0.8 0.078 13.3 0.1 1.7 2 0 0 2 2 2 0 Effector protein TNFR_c6 PF00020.18 EMC80454.1 - 3.2e-08 33.8 17.5 8.6e-06 26.1 4.3 5.9 6 1 0 6 6 6 2 TNFR/NGFR cysteine-rich region Sarcoglycan_1 PF04790.13 EMC80455.1 - 5.3e-82 275.1 0.0 6.5e-82 274.8 0.0 1.0 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein DUF2345 PF10106.9 EMC80455.1 - 0.012 15.5 0.0 0.053 13.4 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2345) FGF PF00167.18 EMC80456.1 - 1.9e-47 160.4 0.3 2.3e-47 160.2 0.3 1.1 1 0 0 1 1 1 1 Fibroblast growth factor EF-hand_7 PF13499.6 EMC80457.1 - 6.7e-12 45.7 9.7 0.00024 21.5 0.1 4.6 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 EMC80457.1 - 1.2e-08 34.7 12.6 1.5e-05 24.8 0.0 5.5 6 1 1 7 7 7 2 EF-hand domain pair EF-hand_1 PF00036.32 EMC80457.1 - 8.6e-08 31.2 15.0 0.00083 18.7 0.2 5.4 6 0 0 6 6 6 2 EF hand EF-hand_6 PF13405.6 EMC80457.1 - 2.4e-07 30.1 8.0 0.0033 17.2 0.2 4.1 5 0 0 5 5 5 2 EF-hand domain EF-hand_4 PF12763.7 EMC80457.1 - 0.022 14.7 1.4 0.077 13.0 0.1 2.6 2 2 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand MHC_I PF00129.18 EMC80457.1 - 0.079 12.5 0.4 0.16 11.5 0.4 1.5 1 0 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 EF-hand_5 PF13202.6 EMC80457.1 - 0.21 11.1 8.1 13 5.5 1.1 3.7 3 0 0 3 3 3 0 EF hand DHHC PF01529.20 EMC80458.1 - 5.7e-36 123.6 17.8 5.7e-36 123.6 17.8 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase Spt4 PF06093.13 EMC80458.1 - 1.4 9.0 6.3 2.8 8.1 6.3 1.4 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger MRP-63 PF14978.6 EMC80459.1 - 9e-37 125.6 2.8 1e-36 125.4 2.8 1.0 1 0 0 1 1 1 1 Mitochondrial ribosome protein 63 Dynamitin PF04912.14 EMC80460.1 - 0.0044 16.4 1.7 0.006 16.0 1.7 1.2 1 0 0 1 1 1 1 Dynamitin CCDC92 PF14916.6 EMC80460.1 - 0.03 14.1 0.2 0.071 12.9 0.2 1.6 1 0 0 1 1 1 0 Coiled-coil domain of unknown function SAP18 PF06487.12 EMC80461.1 - 1.6e-19 70.5 0.0 2.1e-19 70.1 0.0 1.2 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) Pkinase PF00069.25 EMC80463.1 - 2.2e-61 207.6 0.1 2.8e-39 135.1 0.1 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMC80463.1 - 6.8e-29 100.9 0.1 3.8e-20 72.3 0.0 2.7 3 0 0 3 3 3 2 Protein tyrosine kinase UBA PF00627.31 EMC80463.1 - 0.00015 21.6 0.4 0.00028 20.7 0.4 1.5 1 0 0 1 1 1 1 UBA/TS-N domain Pkinase_C PF00433.24 EMC80463.1 - 0.00018 22.1 2.4 0.00018 22.1 2.4 2.3 2 0 0 2 2 2 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 EMC80463.1 - 0.0009 18.3 1.1 0.0018 17.3 1.1 1.4 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EMC80463.1 - 0.0038 17.2 0.1 0.047 13.6 0.1 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EMC80463.1 - 0.01 15.2 0.0 0.023 14.0 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 EMC80463.1 - 0.024 13.6 0.1 0.047 12.7 0.1 1.4 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kinase-like PF14531.6 EMC80463.1 - 0.039 13.3 0.1 0.16 11.3 0.0 1.9 2 0 0 2 2 2 0 Kinase-like Cadherin_tail PF15974.5 EMC80463.1 - 0.069 13.5 0.2 0.069 13.5 0.2 2.6 2 0 0 2 2 2 0 Cadherin C-terminal cytoplasmic tail, catenin-binding region Pkinase_fungal PF17667.1 EMC80463.1 - 0.17 10.6 1.6 0.99 8.1 0.0 2.3 2 0 0 2 2 2 0 Fungal protein kinase CRM1_C PF08767.11 EMC80465.1 - 1.8e-05 24.1 1.2 1.8e-05 24.1 1.2 2.4 2 0 0 2 2 2 1 CRM1 C terminal N6-adenineMlase PF10237.9 EMC80467.1 - 5.4e-57 192.1 0.0 6.7e-57 191.8 0.0 1.1 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase Cons_hypoth95 PF03602.15 EMC80467.1 - 0.00048 19.8 0.0 0.00088 19.0 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 IL17 PF06083.11 EMC80468.1 - 1.8e-22 79.6 0.6 1.8e-22 79.6 0.6 1.7 2 0 0 2 2 2 1 Interleukin-17 TPR_2 PF07719.17 EMC80469.1 - 8.6e-37 122.3 18.1 0.00014 21.7 0.2 11.9 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_1 PF00515.28 EMC80469.1 - 1.6e-34 116.3 29.9 1.1e-06 28.1 0.0 11.3 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_12 PF13424.6 EMC80469.1 - 2.1e-26 92.0 18.3 2.3e-06 27.8 0.0 9.5 5 2 4 9 9 9 6 Tetratricopeptide repeat TPR_7 PF13176.6 EMC80469.1 - 1.7e-25 87.1 9.7 0.00014 21.6 0.0 10.1 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_8 PF13181.6 EMC80469.1 - 4.1e-23 79.6 36.9 0.0018 18.4 0.2 12.7 13 0 0 13 13 13 6 Tetratricopeptide repeat TPR_19 PF14559.6 EMC80469.1 - 1.7e-21 76.5 7.4 1.1e-06 29.0 0.2 6.9 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_6 PF13174.6 EMC80469.1 - 3.4e-19 68.1 18.5 0.02 15.5 0.0 10.4 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_16 PF13432.6 EMC80469.1 - 1.9e-16 60.4 0.4 7.6e-05 23.3 0.0 5.4 6 0 0 6 6 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 EMC80469.1 - 5.2e-14 51.8 0.5 0.26 12.2 0.0 8.0 4 1 3 8 8 8 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC80469.1 - 6.3e-13 48.8 21.5 3.9e-07 30.2 3.6 5.8 4 2 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EMC80469.1 - 1.2e-11 44.1 21.3 3.1e-07 30.0 0.6 7.6 7 1 1 8 8 8 3 TPR repeat TPR_10 PF13374.6 EMC80469.1 - 1.5e-07 31.1 23.7 0.52 10.3 0.2 10.0 11 0 0 11 11 11 3 Tetratricopeptide repeat TPR_21 PF09976.9 EMC80469.1 - 1.6e-06 28.0 8.8 0.0005 19.8 3.7 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat-like domain TPR_9 PF13371.6 EMC80469.1 - 3.5e-05 23.9 0.0 7.6 6.8 0.0 5.3 4 2 1 5 5 5 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EMC80469.1 - 0.00018 21.0 0.1 0.41 10.0 0.0 3.4 2 1 1 3 3 3 1 MalT-like TPR region TPR_17 PF13431.6 EMC80469.1 - 0.0003 21.0 31.0 0.16 12.4 0.5 9.7 11 0 0 11 11 9 2 Tetratricopeptide repeat DUF3808 PF10300.9 EMC80469.1 - 0.00044 19.1 0.2 0.00044 19.1 0.2 3.0 3 1 0 3 3 3 1 Protein of unknown function (DUF3808) TPR_15 PF13429.6 EMC80469.1 - 0.00066 19.0 10.1 0.007 15.6 6.4 3.9 2 2 1 3 3 3 1 Tetratricopeptide repeat FumaraseC_C PF10415.9 EMC80469.1 - 0.0012 19.2 2.1 0.18 12.2 0.1 3.7 3 0 0 3 3 3 1 Fumarase C C-terminus BTAD PF03704.17 EMC80469.1 - 0.0015 19.0 3.3 0.39 11.1 0.1 4.4 4 2 0 4 4 4 1 Bacterial transcriptional activator domain Sel1 PF08238.12 EMC80469.1 - 0.0025 18.4 14.1 3 8.7 0.0 6.6 8 0 0 8 8 5 1 Sel1 repeat SbsC_C PF18058.1 EMC80469.1 - 0.0082 16.4 1.1 3.6 7.8 0.0 2.9 2 0 0 2 2 2 1 SbsC C-terminal domain Coatomer_E PF04733.14 EMC80469.1 - 0.014 14.8 6.1 0.075 12.4 0.1 3.8 4 2 0 4 4 4 0 Coatomer epsilon subunit DUF4810 PF16068.5 EMC80469.1 - 0.025 15.1 6.4 1.3 9.6 0.0 5.6 6 1 1 7 7 5 0 Domain of unknown function (DUF4810) TPR_20 PF14561.6 EMC80469.1 - 0.031 14.6 7.6 4 7.8 0.1 5.2 3 1 2 5 5 5 0 Tetratricopeptide repeat ORC6 PF05460.13 EMC80469.1 - 0.19 11.0 3.1 2.9 7.1 0.0 3.0 3 0 0 3 3 3 0 Origin recognition complex subunit 6 (ORC6) PPR PF01535.20 EMC80469.1 - 0.37 11.1 9.8 77 3.9 0.0 6.6 8 0 0 8 8 6 0 PPR repeat FRB_dom PF08771.11 EMC80469.1 - 0.45 10.9 3.4 13 6.2 0.1 3.4 4 0 0 4 4 2 0 FKBP12-rapamycin binding domain DUF2989 PF11207.8 EMC80469.1 - 1.4 8.6 20.7 1.8 8.3 0.0 4.2 4 1 1 5 5 5 0 Protein of unknown function (DUF2989) 3HCDH_N PF02737.18 EMC80470.1 - 7.3e-49 166.1 0.0 9.4e-49 165.7 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EMC80470.1 - 1.3e-14 54.6 0.0 2.4e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Chlorophyllase2 PF12740.7 EMC80470.1 - 0.049 12.5 0.0 0.068 12.1 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme MAP70 PF07058.11 EMC80470.1 - 0.055 12.2 0.6 0.075 11.8 0.6 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 NAD_binding_2 PF03446.15 EMC80470.1 - 0.18 12.0 0.0 0.36 11.0 0.0 1.5 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ApoC-I PF04691.12 EMC80470.1 - 0.52 10.3 3.8 14 5.7 0.3 3.1 3 1 0 3 3 3 0 Apolipoprotein C-I (ApoC-1) Connexin PF00029.19 EMC80471.1 - 6e-87 291.3 10.9 6e-87 291.3 10.9 2.5 2 1 0 2 2 2 1 Connexin Connexin PF00029.19 EMC80472.1 - 1.6e-87 293.1 10.8 1e-85 287.2 10.8 2.0 1 1 0 1 1 1 1 Connexin zf-FCS PF06467.14 EMC80473.1 - 2e-65 216.4 118.1 9.4e-10 38.3 3.6 10.6 10 0 0 10 10 10 10 MYM-type Zinc finger with FCS sequence motif DUF3504 PF12012.8 EMC80473.1 - 4.6e-62 208.8 1.8 4.6e-62 208.8 1.8 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3504) YHS PF04945.13 EMC80473.1 - 0.0003 20.8 3.0 0.0024 17.9 0.2 9.5 9 0 0 9 9 9 3 YHS domain Arc_trans_TRASH PF08394.10 EMC80473.1 - 0.00071 19.9 5.1 0.00071 19.9 5.1 7.1 9 0 0 9 9 9 1 Archaeal TRASH domain NosL PF05573.12 EMC80473.1 - 0.25 11.7 6.9 6.4 7.1 0.3 4.0 3 1 1 4 4 4 0 NosL Ribosomal_L24e PF01246.20 EMC80473.1 - 6.4 7.1 34.1 0.068 13.4 0.5 7.5 6 1 1 7 7 7 0 Ribosomal protein L24e RRM_1 PF00076.22 EMC80474.1 - 8.4e-33 112.0 0.0 1.2e-15 57.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOPS PF08075.11 EMC80474.1 - 2.3e-25 88.5 1.5 2.3e-25 88.5 1.5 2.1 2 0 0 2 2 2 1 NOPS (NUC059) domain RRM_7 PF16367.5 EMC80474.1 - 0.00055 20.0 0.0 0.0034 17.5 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif Zot PF05707.12 EMC80474.1 - 1.3 8.6 3.4 2.3 7.8 3.4 1.5 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) Aldedh PF00171.22 EMC80474.1 - 3.2 6.2 5.3 4.7 5.6 5.3 1.2 1 0 0 1 1 1 0 Aldehyde dehydrogenase family MRP-S26 PF14943.6 EMC80474.1 - 4.8 7.1 20.8 7.6 6.4 20.8 1.3 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Exonuc_VII_L PF02601.15 EMC80474.1 - 6.5 6.2 11.0 10 5.6 11.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Ank_2 PF12796.7 EMC80476.1 - 1.7e-19 70.2 1.5 1.2e-10 41.8 0.1 2.6 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC80476.1 - 7.4e-18 64.4 0.1 4.1e-10 39.7 0.0 2.7 1 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC80476.1 - 2.9e-17 62.8 0.6 1.5e-06 28.6 0.0 4.4 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC80476.1 - 6.9e-13 47.5 0.8 4.1e-05 23.6 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 EMC80476.1 - 1.2e-10 41.3 0.8 0.00032 21.0 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Chromo PF00385.24 EMC80476.1 - 4.4e-10 39.3 0.7 1.9e-09 37.3 0.7 2.2 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Snapin_Pallidin PF14712.6 EMC80478.1 - 0.48 10.9 7.3 0.14 12.6 3.0 2.4 2 1 0 2 2 2 0 Snapin/Pallidin DP PF08781.10 EMC80478.1 - 4.1 7.3 12.5 0.087 12.7 3.9 2.5 3 0 0 3 3 3 0 Transcription factor DP Tcp10_C PF07202.13 EMC80479.1 - 2.2e-86 288.3 7.4 2.2e-86 288.3 6.6 1.4 1 1 0 1 1 1 1 T-complex protein 10 C-terminus Plant_vir_prot PF01307.17 EMC80479.1 - 0.02 15.1 0.2 5.3 7.3 0.0 2.7 1 1 2 3 3 3 0 Plant viral movement protein PepSY_like PF11396.8 EMC80479.1 - 0.028 14.9 0.7 0.25 11.9 0.2 2.6 1 1 1 2 2 2 0 Putative beta-lactamase-inhibitor-like, PepSY-like FecR PF04773.13 EMC80479.1 - 0.072 13.7 0.1 11 6.7 0.0 3.4 1 1 2 3 3 3 0 FecR protein TUDOR PF00567.24 EMC80480.1 - 4.3e-40 136.5 0.5 3.1e-21 75.7 0.1 3.0 2 1 0 2 2 2 2 Tudor domain Agenet PF05641.12 EMC80480.1 - 2.6e-07 31.0 0.5 0.0089 16.5 0.1 2.6 2 0 0 2 2 2 2 Agenet domain TUDOR PF00567.24 EMC80481.1 - 8.6e-51 171.1 7.8 6.2e-22 77.9 0.1 5.1 5 0 0 5 5 5 4 Tudor domain Agenet PF05641.12 EMC80481.1 - 0.00074 19.9 0.2 0.18 12.3 0.0 3.5 3 0 0 3 3 3 1 Agenet domain STAS PF01740.21 EMC80481.1 - 0.031 13.9 0.0 0.089 12.4 0.0 1.7 1 0 0 1 1 1 0 STAS domain Tudor_2 PF18104.1 EMC80481.1 - 0.18 11.5 0.0 0.35 10.6 0.0 1.5 1 0 0 1 1 1 0 Jumonji domain-containing protein 2A Tudor domain RVT_1 PF00078.27 EMC80482.1 - 0.03 13.8 0.0 0.071 12.6 0.0 1.7 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RhoGAP PF00620.27 EMC80483.1 - 4e-41 140.4 0.0 5.1e-41 140.0 0.0 1.1 1 0 0 1 1 1 1 RhoGAP domain Nod1 PF17114.5 EMC80483.1 - 6.5e-07 29.6 0.1 4.7e-06 26.8 0.1 2.1 1 1 0 1 1 1 1 Gef2-related medial cortical node protein Nod1 DUF2183 PF09949.9 EMC80483.1 - 0.13 12.6 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2183) RHH_7 PF16777.5 EMC80484.1 - 0.02 15.3 4.3 0.023 15.1 0.1 2.7 3 0 0 3 3 3 0 Transcriptional regulator, RHH-like, CopG Fer2 PF00111.27 EMC80485.1 - 7.9e-08 32.2 0.2 1.1e-07 31.7 0.2 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain CTU2 PF10288.9 EMC80485.1 - 0.026 14.8 0.0 0.13 12.5 0.0 1.9 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 Zf_RING PF16744.5 EMC80485.1 - 0.037 14.1 0.4 0.68 10.1 0.5 2.0 1 1 1 2 2 2 0 KIAA1045 RING finger zf-CHY PF05495.12 EMC80485.1 - 0.055 14.0 0.3 0.1 13.1 0.3 1.4 1 1 0 1 1 1 0 CHY zinc finger ERM PF00769.19 EMC80486.1 - 1.7e-72 244.2 48.3 1.7e-72 244.2 48.3 2.5 2 1 1 3 3 3 1 Ezrin/radixin/moesin family FERM_C PF09380.10 EMC80486.1 - 3.6e-28 97.8 0.0 1.4e-27 95.9 0.0 2.1 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 EMC80486.1 - 1.1e-27 96.8 1.5 1.1e-27 96.8 1.5 3.6 2 1 0 2 2 2 1 FERM central domain FERM_N PF09379.10 EMC80486.1 - 3.1e-15 55.8 0.8 1.6e-14 53.5 0.1 2.5 2 0 0 2 2 2 1 FERM N-terminal domain Mito_fiss_reg PF05308.11 EMC80486.1 - 0.0039 17.3 25.7 0.0039 17.3 25.7 2.1 1 1 1 2 2 2 1 Mitochondrial fission regulator RNase_Zc3h12a PF11977.8 EMC80487.1 - 2.4e-65 219.0 0.0 3.7e-65 218.5 0.0 1.3 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain Regnase_1_C PF18561.1 EMC80487.1 - 2e-26 91.4 0.3 3.8e-26 90.6 0.3 1.5 1 0 0 1 1 1 1 Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain zf-CCCH_4 PF18044.1 EMC80487.1 - 0.00022 20.9 7.0 0.00044 20.0 7.0 1.6 1 0 0 1 1 1 1 CCCH-type zinc finger PRORP PF16953.5 EMC80487.1 - 0.18 11.3 0.0 0.52 9.8 0.0 1.6 2 0 0 2 2 2 0 Protein-only RNase P PLU-1 PF08429.11 EMC80488.1 - 0.043 13.0 8.1 0.027 13.6 4.6 2.2 2 1 0 2 2 2 0 PLU-1-like protein Adeno_E1B_19K PF01691.16 EMC80489.1 - 0.093 12.3 0.1 0.12 12.0 0.1 1.1 1 0 0 1 1 1 0 Adenovirus E1B 19K protein / small t-antigen DUF4276 PF14103.6 EMC80489.1 - 0.12 12.5 0.1 0.16 12.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4276) CD34_antigen PF06365.12 EMC80490.1 - 3.2e-05 23.6 0.1 3.7e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 CD34/Podocalyxin family DUF4834 PF16118.5 EMC80490.1 - 0.0039 18.1 0.0 0.0052 17.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) TMEM154 PF15102.6 EMC80490.1 - 0.0046 16.9 0.0 0.0072 16.2 0.0 1.4 1 0 0 1 1 1 1 TMEM154 protein family OSTbeta PF15048.6 EMC80490.1 - 0.0056 16.8 0.0 0.0074 16.4 0.0 1.2 1 0 0 1 1 1 1 Organic solute transporter subunit beta protein TMEM51 PF15345.6 EMC80490.1 - 0.0079 16.1 0.1 0.01 15.7 0.1 1.2 1 0 0 1 1 1 1 Transmembrane protein 51 LapA_dom PF06305.11 EMC80490.1 - 0.0092 15.8 0.1 0.017 15.0 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain 7tm_1 PF00001.21 EMC80490.1 - 0.0093 15.3 0.0 0.0097 15.3 0.0 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3328 PF11807.8 EMC80490.1 - 0.015 15.1 0.0 0.02 14.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) DUF3169 PF11368.8 EMC80490.1 - 0.019 14.5 0.0 0.023 14.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) Tmemb_9 PF05434.11 EMC80490.1 - 0.02 14.8 0.0 0.026 14.4 0.0 1.3 1 0 0 1 1 1 0 TMEM9 TssO PF17561.2 EMC80490.1 - 0.025 14.7 0.8 0.034 14.2 0.8 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssO SID-1_RNA_chan PF13965.6 EMC80490.1 - 0.032 12.6 0.0 0.036 12.5 0.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 OAD_gamma PF04277.13 EMC80490.1 - 0.033 14.8 0.1 0.069 13.8 0.0 1.6 2 0 0 2 2 1 0 Oxaloacetate decarboxylase, gamma chain DUF2663 PF10864.8 EMC80490.1 - 0.035 14.5 0.1 0.046 14.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2663) Phage_Gp23 PF10669.9 EMC80490.1 - 0.037 14.4 0.0 0.048 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) EphA2_TM PF14575.6 EMC80490.1 - 0.039 14.8 0.3 0.068 14.1 0.3 1.4 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain V_ATPase_I PF01496.19 EMC80490.1 - 0.043 11.7 0.1 0.046 11.6 0.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Miga PF10265.9 EMC80490.1 - 0.053 12.5 0.2 0.062 12.3 0.2 1.0 1 0 0 1 1 1 0 Mitoguardin Afaf PF15339.6 EMC80490.1 - 0.092 12.5 0.1 0.12 12.1 0.1 1.2 1 0 0 1 1 1 0 Acrosome formation-associated factor ATP-synt_8 PF00895.20 EMC80490.1 - 0.1 13.1 0.3 0.22 12.0 0.3 1.6 1 0 0 1 1 1 0 ATP synthase protein 8 DUF2207 PF09972.9 EMC80490.1 - 0.15 10.8 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Brr6_like_C_C PF10104.9 EMC80490.1 - 1.7 8.4 7.0 2.1 8.1 5.4 1.7 1 1 1 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain DEAD PF00270.29 EMC80491.1 - 1.3e-46 158.6 0.9 3.5e-46 157.2 0.1 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC80491.1 - 1.2e-25 90.0 0.0 1.4e-24 86.6 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EMC80491.1 - 5.8e-18 64.9 0.3 1.3e-17 63.7 0.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EMC80491.1 - 1.1e-10 41.8 0.0 1.1e-10 41.8 0.0 3.0 3 2 0 3 3 3 1 Type III restriction enzyme, res subunit Capsid-VNN PF11729.8 EMC80492.1 - 0.00077 18.6 13.0 3 6.8 0.4 4.3 1 1 4 5 5 5 5 nodavirus capsid protein bZIP_Maf PF03131.17 EMC80493.1 - 0.12 12.9 0.3 0.12 12.9 0.3 2.9 3 0 0 3 3 3 0 bZIP Maf transcription factor Glyco_transf_90 PF05686.12 EMC80494.1 - 6.4e-86 288.7 0.1 8.2e-86 288.4 0.1 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 90 Filamin PF00630.19 EMC80494.1 - 0.0022 18.8 0.0 0.0044 17.8 0.0 1.6 1 0 0 1 1 1 1 Filamin/ABP280 repeat Glyco_trans_1_2 PF13524.6 EMC80494.1 - 0.0044 17.4 0.0 0.0086 16.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Thiolase_N PF00108.23 EMC80495.1 - 3.2e-95 318.4 2.0 5.6e-95 317.6 2.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EMC80495.1 - 2.3e-46 156.5 2.4 8.2e-46 154.6 1.5 2.2 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EMC80495.1 - 4.2e-06 26.5 5.2 3.7e-05 23.4 4.1 2.7 2 1 1 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.10 EMC80495.1 - 0.11 12.7 0.8 0.77 10.0 0.0 2.6 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Cullin PF00888.22 EMC80496.1 - 4.3e-191 636.7 17.6 5.7e-191 636.3 17.6 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EMC80496.1 - 5.5e-18 64.8 5.0 2.1e-17 62.9 5.0 2.0 1 0 0 1 1 1 1 Cullin protein neddylation domain Stork_head PF10264.9 EMC80496.1 - 0.023 14.8 2.0 0.044 13.9 0.8 2.1 2 0 0 2 2 2 0 Winged helix Storkhead-box1 domain Ras PF00071.22 EMC80497.1 - 3.2e-29 101.6 0.1 3.9e-29 101.3 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC80497.1 - 4.9e-06 26.7 0.0 1e-05 25.7 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC80497.1 - 0.028 13.9 0.0 0.035 13.6 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosylation factor family zf-C2H2_3 PF13878.6 EMC80497.1 - 0.073 12.9 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO SLC35F PF06027.12 EMC80498.1 - 4.7e-126 420.3 29.8 5.3e-126 420.2 29.8 1.0 1 0 0 1 1 1 1 Solute carrier family 35 EamA PF00892.20 EMC80498.1 - 1.5e-13 51.1 34.9 1.6e-08 34.8 17.9 2.0 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 EMC80498.1 - 2.1e-09 36.8 10.4 2.1e-09 36.8 10.4 2.0 1 1 1 2 2 2 1 CRT-like, chloroquine-resistance transporter-like UAA PF08449.11 EMC80498.1 - 8e-09 35.1 24.7 1.3e-08 34.4 24.7 1.2 1 0 0 1 1 1 1 UAA transporter family Sarcolipin PF05366.11 EMC80499.1 - 2.3e-20 72.0 4.5 2.4e-20 71.9 4.5 1.0 1 0 0 1 1 1 1 Sarcolipin Phospholamban PF04272.14 EMC80499.1 - 0.00025 20.5 0.5 0.00027 20.3 0.5 1.1 1 0 0 1 1 1 1 Phospholamban ELMO_CED12 PF04727.13 EMC80500.1 - 1.6e-47 161.9 0.5 2.1e-47 161.5 0.1 1.4 2 0 0 2 2 2 1 ELMO/CED-12 family 2OG-FeII_Oxy_2 PF13532.6 EMC80501.1 - 2.1e-21 77.0 0.0 5.1e-21 75.8 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Methyltransf_11 PF08241.12 EMC80501.1 - 2.1e-13 50.7 0.0 5.5e-13 49.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC80501.1 - 5.3e-12 46.3 0.1 1.9e-11 44.5 0.1 2.0 1 0 0 1 1 1 1 Methyltransferase domain RRM_1 PF00076.22 EMC80501.1 - 4.3e-09 36.1 0.0 1.1e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Methyltransf_8 PF05148.15 EMC80501.1 - 1.8e-05 24.7 0.0 3.5e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_31 PF13847.6 EMC80501.1 - 4.7e-05 23.2 0.0 9.9e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC80501.1 - 0.00012 22.0 0.0 0.00041 20.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC80501.1 - 0.00012 22.8 0.0 0.00032 21.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain DUF1891 PF09004.10 EMC80501.1 - 0.0017 17.9 0.4 0.0038 16.8 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1891) 2OG-FeII_Oxy PF03171.20 EMC80501.1 - 0.026 15.0 0.0 0.071 13.6 0.0 1.7 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Ubie_methyltran PF01209.18 EMC80501.1 - 0.031 13.6 0.0 0.092 12.1 0.0 1.7 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.7 EMC80501.1 - 0.053 13.5 0.1 9.1 6.2 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain MetW PF07021.12 EMC80501.1 - 0.1 12.2 0.1 0.2 11.3 0.1 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_9 PF08003.11 EMC80501.1 - 0.11 11.4 0.0 0.18 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) ILEI PF15711.5 EMC80501.1 - 0.18 12.3 0.0 3.3 8.3 0.0 2.8 3 0 0 3 3 3 0 Interleukin-like EMT inducer CwfJ_C_1 PF04677.15 EMC80502.1 - 3e-38 130.4 0.7 8.8e-38 128.9 0.7 1.8 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 EMC80502.1 - 7.3e-32 110.2 0.1 7.3e-32 110.2 0.1 3.8 3 0 0 3 3 3 1 Protein similar to CwfJ C-terminus 2 NuDC PF16273.5 EMC80502.1 - 0.015 15.8 0.6 0.015 15.8 0.6 6.5 6 0 0 6 6 6 0 Nuclear distribution C domain VOMI PF03762.17 EMC80503.1 - 4e-52 176.8 1.3 4.7e-52 176.5 1.3 1.1 1 0 0 1 1 1 1 Vitelline membrane outer layer protein I (VOMI) Guanylate_cyc PF00211.20 EMC80504.1 - 4.3e-62 209.0 0.0 7e-62 208.3 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 EMC80504.1 - 4.1e-49 167.0 3.4 2.3e-47 161.3 3.4 2.3 1 1 0 1 1 1 1 Heme NO binding associated HNOB PF07700.15 EMC80504.1 - 4.7e-18 65.7 0.1 8.8e-18 64.8 0.1 1.4 1 0 0 1 1 1 1 Haem-NO-binding DUF4761 PF15958.5 EMC80504.1 - 0.15 12.2 0.0 0.32 11.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4761) RhoGAP PF00620.27 EMC80505.1 - 9.7e-80 265.7 3.4 9.5e-31 106.7 0.3 7.3 4 3 3 7 7 7 7 RhoGAP domain AAA_19 PF13245.6 EMC80505.1 - 0.00019 21.8 0.6 4.4 7.6 0.0 4.2 4 0 0 4 4 4 2 AAA domain LepB_N PF18640.1 EMC80505.1 - 0.0047 16.6 1.6 16 5.1 0.0 3.7 4 0 0 4 4 4 2 LepB N-terminal domain DUF3160 PF11369.8 EMC80505.1 - 2.3 6.6 6.1 42 2.4 0.1 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3160) IDO PF01231.18 EMC80505.1 - 7.8 5.2 5.8 70 2.0 0.2 3.5 4 0 0 4 4 4 0 Indoleamine 2,3-dioxygenase ACPS PF01648.20 EMC80506.1 - 5.6e-19 68.3 0.1 8.2e-17 61.4 0.0 2.3 2 0 0 2 2 2 2 4'-phosphopantetheinyl transferase superfamily BTB PF00651.31 EMC80507.1 - 3.3e-27 94.9 0.9 3.3e-27 94.9 0.9 2.2 2 0 0 2 2 2 1 BTB/POZ domain Kelch_6 PF13964.6 EMC80507.1 - 3.6e-26 90.5 3.4 2.1e-05 24.6 0.0 6.6 3 1 3 6 6 6 5 Kelch motif BACK PF07707.15 EMC80507.1 - 6e-26 90.5 3.4 6e-26 90.5 3.4 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_1 PF01344.25 EMC80507.1 - 1.1e-25 88.9 7.5 1.3e-06 27.9 0.0 6.3 6 1 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 EMC80507.1 - 8.2e-12 44.9 0.0 0.08 13.0 0.0 5.1 4 1 1 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.6 EMC80507.1 - 1.7e-09 37.7 0.0 0.82 10.0 0.0 5.0 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.15 EMC80507.1 - 1.8e-06 27.7 5.2 0.11 12.6 0.0 5.8 6 1 0 6 6 6 2 Kelch motif Kelch_5 PF13854.6 EMC80507.1 - 0.0085 16.1 0.5 7.3 6.7 0.0 3.6 3 0 0 3 3 3 1 Kelch motif Myb_DNA-bind_5 PF13873.6 EMC80508.1 - 4.1e-23 81.2 7.1 4.1e-23 81.2 7.1 2.2 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Myb_DNA-binding PF00249.31 EMC80508.1 - 0.00051 20.2 0.9 0.00051 20.2 0.9 2.5 3 0 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EMC80508.1 - 0.01 16.2 2.8 0.027 14.8 2.8 1.7 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain ANF_receptor PF01094.28 EMC80509.1 - 1.6e-65 221.5 0.0 2.2e-65 221.1 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.26 EMC80509.1 - 6.9e-60 201.2 0.0 1.1e-59 200.5 0.0 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 EMC80509.1 - 1.1e-44 151.3 0.3 2.4e-44 150.2 0.0 1.7 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 EMC80509.1 - 6.2e-23 81.4 0.0 1.1e-22 80.5 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.6 EMC80509.1 - 0.0059 16.3 0.0 0.012 15.3 0.0 1.4 1 1 0 1 1 1 1 Periplasmic binding protein Ion_trans_2 PF07885.16 EMC80509.1 - 7.6 6.6 7.8 5.2 7.1 0.1 3.3 3 0 0 3 3 3 0 Ion channel CUB PF00431.20 EMC80510.1 - 8.4e-20 71.2 0.0 1.6e-19 70.2 0.0 1.4 1 0 0 1 1 1 1 CUB domain PDGF PF00341.17 EMC80510.1 - 5.4e-17 61.9 6.2 9.4e-17 61.1 6.2 1.4 1 0 0 1 1 1 1 PDGF/VEGF domain DUF262 PF03235.14 EMC80511.1 - 0.29 11.3 18.2 0.34 11.0 18.2 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 DUF5427 PF10310.9 EMC80511.1 - 0.85 8.5 35.4 0.91 8.4 35.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) SLC12 PF03522.15 EMC80511.1 - 1.4 7.8 29.1 1.6 7.7 29.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 AAA_11 PF13086.6 EMC80511.1 - 3.3 7.4 28.7 3.9 7.2 28.7 1.1 1 0 0 1 1 1 0 AAA domain PTPRCAP PF15713.5 EMC80511.1 - 3.6 7.9 38.7 5.4 7.3 38.7 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated ALMT PF11744.8 EMC80511.1 - 3.8 6.2 23.2 4.3 6.1 23.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter RR_TM4-6 PF06459.12 EMC80511.1 - 4.1 7.2 45.8 5.2 6.8 45.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 EMC80511.1 - 4.3 6.0 34.2 4.7 5.9 34.2 1.0 1 0 0 1 1 1 0 Presenilin DUF4045 PF13254.6 EMC80511.1 - 4.5 6.8 33.8 5.2 6.6 33.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Trypan_PARP PF05887.11 EMC80511.1 - 5.1 7.1 44.6 4.6 7.2 27.4 2.0 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) Rrn6 PF10214.9 EMC80511.1 - 6.1 5.2 17.8 7.3 4.9 17.8 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor TT_ORF1 PF02956.14 EMC80511.1 - 7.1 5.2 13.0 8.3 5.0 13.0 1.1 1 0 0 1 1 1 0 TT viral orf 1 Endostatin PF06482.11 EMC80511.1 - 9.9 5.5 15.7 11 5.4 15.7 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Cullin_binding PF03556.15 EMC80512.1 - 3e-30 105.1 4.5 4.7e-30 104.5 4.5 1.3 1 0 0 1 1 1 1 Cullin binding Peptidase_M10 PF00413.24 EMC80513.1 - 3e-65 218.9 0.0 4.5e-65 218.3 0.0 1.3 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 EMC80513.1 - 1e-40 137.4 3.2 2.5e-13 49.7 0.0 4.4 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.18 EMC80513.1 - 9.8e-11 41.7 0.0 1.8e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.24 EMC80513.1 - 0.013 15.1 0.1 3.3 7.3 0.0 2.3 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.6 EMC80513.1 - 0.014 15.9 0.0 0.031 14.8 0.0 1.7 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EMC80513.1 - 0.053 13.2 0.0 0.086 12.5 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 EMC80513.1 - 0.059 12.6 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Met-zincin Reprolysin_5 PF13688.6 EMC80513.1 - 0.074 13.2 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12 MerR_2 PF13591.6 EMC80513.1 - 0.1 12.5 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 MerR HTH family regulatory protein Peptidase_M10 PF00413.24 EMC80514.1 - 3.2e-62 209.0 0.0 6.3e-62 208.1 0.0 1.5 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 EMC80514.1 - 5.6e-46 154.3 8.7 1.5e-14 53.7 0.0 4.5 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.18 EMC80514.1 - 2.7e-10 40.3 0.0 5.2e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.24 EMC80514.1 - 0.0054 16.4 0.1 2.9 7.5 0.2 2.3 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.6 EMC80514.1 - 0.0097 16.4 0.1 0.02 15.4 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EMC80514.1 - 0.049 13.8 0.3 0.089 12.9 0.3 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 DUF4953 PF16313.5 EMC80514.1 - 0.052 12.7 0.1 0.091 11.9 0.1 1.3 1 0 0 1 1 1 0 Met-zincin Reprolysin_4 PF13583.6 EMC80514.1 - 0.17 11.5 0.1 0.33 10.6 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.8 EMC80514.1 - 0.18 11.4 0.1 0.32 10.6 0.1 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Peptidase_M10 PF00413.24 EMC80515.1 - 9.6e-60 201.0 0.1 1.7e-59 200.2 0.1 1.4 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 EMC80515.1 - 8.6e-36 121.6 13.3 5.1e-09 35.9 0.6 4.3 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.18 EMC80515.1 - 1.7e-07 31.3 0.0 3.1e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.24 EMC80515.1 - 0.00024 20.8 0.0 0.17 11.5 0.0 2.5 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.6 EMC80515.1 - 0.0089 16.5 0.0 0.017 15.6 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EMC80515.1 - 0.019 15.2 0.2 0.029 14.5 0.2 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 EMC80515.1 - 0.041 13.5 0.1 0.066 12.8 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 EMC80515.1 - 0.079 12.2 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 Met-zincin Peptidase_M10 PF00413.24 EMC80516.1 - 1.7e-60 203.5 0.0 3e-60 202.7 0.0 1.4 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 EMC80516.1 - 2.9e-36 123.1 10.0 2.3e-11 43.4 0.6 4.3 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.18 EMC80516.1 - 4.2e-11 42.9 0.1 1e-10 41.6 0.1 1.7 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Reprolysin_3 PF13582.6 EMC80516.1 - 0.00011 22.8 0.0 0.00043 20.8 0.0 2.0 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 EMC80516.1 - 0.00024 20.8 0.2 0.38 10.4 0.1 2.4 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Reprolysin_4 PF13583.6 EMC80516.1 - 0.0021 17.7 0.1 0.0039 16.9 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EMC80516.1 - 0.003 17.7 0.0 0.0043 17.2 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M54 PF07998.11 EMC80516.1 - 0.0085 16.1 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M54 DUF4953 PF16313.5 EMC80516.1 - 0.052 12.7 0.5 0.093 11.9 0.0 1.6 2 0 0 2 2 2 0 Met-zincin Peptidase_M66 PF10462.9 EMC80516.1 - 0.057 12.4 0.1 0.1 11.5 0.1 1.3 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M57 PF12388.8 EMC80516.1 - 0.087 12.4 0.2 0.14 11.7 0.2 1.2 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Metallopep PF12044.8 EMC80516.1 - 0.24 10.0 0.0 0.38 9.3 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family Peptidase_M10 PF00413.24 EMC80517.1 - 3.9e-60 202.3 0.0 7e-60 201.4 0.0 1.4 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 EMC80517.1 - 2.8e-40 136.0 6.4 1.9e-12 46.9 0.1 4.3 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.18 EMC80517.1 - 1e-13 51.3 0.1 1e-12 48.1 0.1 2.3 2 0 0 2 2 2 1 Putative peptidoglycan binding domain Reprolysin_3 PF13582.6 EMC80517.1 - 0.00018 22.0 0.0 0.00043 20.8 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 EMC80517.1 - 0.0016 18.1 0.2 0.23 11.0 0.1 2.3 2 0 0 2 2 2 1 Astacin (Peptidase family M12A) Reprolysin_4 PF13583.6 EMC80517.1 - 0.0048 16.6 0.0 0.0081 15.8 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EMC80517.1 - 0.011 15.9 0.0 0.017 15.3 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 DUF4953 PF16313.5 EMC80517.1 - 0.021 14.0 0.3 0.034 13.3 0.3 1.2 1 0 0 1 1 1 0 Met-zincin Peptidase_M54 PF07998.11 EMC80517.1 - 0.031 14.3 0.0 0.06 13.3 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M54 Peptidase_M66 PF10462.9 EMC80517.1 - 0.036 13.0 0.1 0.063 12.2 0.1 1.3 1 0 0 1 1 1 0 Peptidase M66 Metallopep PF12044.8 EMC80517.1 - 0.091 11.3 0.0 0.14 10.7 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family Reprolysin_2 PF13574.6 EMC80517.1 - 0.11 12.4 0.1 0.25 11.2 0.1 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 EMC80518.1 - 1.9e-63 213.0 0.0 2.6e-63 212.6 0.0 1.2 1 0 0 1 1 1 1 Matrixin PG_binding_1 PF01471.18 EMC80518.1 - 5.1e-09 36.2 0.0 8.2e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Putative peptidoglycan binding domain DUF4953 PF16313.5 EMC80518.1 - 0.0095 15.2 0.1 0.014 14.6 0.1 1.2 1 0 0 1 1 1 1 Met-zincin Astacin PF01400.24 EMC80518.1 - 0.0096 15.6 0.2 2.1 7.9 0.2 2.2 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Reprolysin_4 PF13583.6 EMC80518.1 - 0.018 14.7 0.0 0.028 14.1 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 EMC80518.1 - 0.032 14.8 0.8 0.056 14.0 0.9 1.4 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EMC80518.1 - 0.088 12.9 0.6 0.13 12.4 0.6 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M66 PF10462.9 EMC80518.1 - 0.14 11.1 0.2 0.2 10.6 0.2 1.2 1 0 0 1 1 1 0 Peptidase M66 MGC-24 PF05283.11 EMC80519.1 - 1.4e-10 41.8 8.0 1.7e-10 41.5 8.0 1.2 1 0 0 1 1 1 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin FSA_C PF10479.9 EMC80519.1 - 0.023 12.8 5.9 0.026 12.7 5.9 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus MLANA PF14991.6 EMC80519.1 - 1.8 8.9 3.9 1.5 9.2 0.7 1.9 1 1 1 2 2 2 0 Protein melan-A BIR PF00653.21 EMC80520.1 - 3.8e-65 216.5 13.3 1.2e-21 77.1 0.8 3.9 4 0 0 4 4 4 3 Inhibitor of Apoptosis domain CARD PF00619.21 EMC80520.1 - 1.6e-22 79.3 0.2 3.6e-22 78.2 0.2 1.6 1 0 0 1 1 1 1 Caspase recruitment domain zf-C3HC4_3 PF13920.6 EMC80520.1 - 1.3e-14 53.8 8.2 1.3e-14 53.8 8.2 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC80520.1 - 8.8e-08 31.9 7.9 2.8e-07 30.3 7.9 2.0 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EMC80520.1 - 0.0056 16.6 7.1 0.0056 16.6 7.1 2.3 2 0 0 2 2 2 1 zinc-RING finger domain DUF2039 PF10217.9 EMC80520.1 - 0.12 12.7 4.4 0.34 11.3 4.4 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) zf-RING_UBOX PF13445.6 EMC80520.1 - 0.31 11.1 6.2 0.69 10.0 3.5 2.6 1 1 1 2 2 2 0 RING-type zinc-finger RNA_pol_N PF01194.17 EMC80520.1 - 0.41 11.0 8.7 2.7 8.3 0.1 3.3 3 0 0 3 3 3 0 RNA polymerases N / 8 kDa subunit zf-C3HC4_2 PF13923.6 EMC80520.1 - 0.46 10.4 13.6 0.21 11.4 9.9 2.6 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) DUF1644 PF07800.12 EMC80520.1 - 6.1 6.9 7.4 14 5.8 1.0 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1644) WW PF00397.26 EMC80521.1 - 5.2e-22 77.6 2.6 3e-10 40.0 0.1 2.6 2 0 0 2 2 2 2 WW domain MbtH PF03621.13 EMC80521.1 - 0.01 15.3 0.0 0.85 9.1 0.0 2.4 2 0 0 2 2 2 0 MbtH-like protein TFIIA PF03153.13 EMC80521.1 - 2.1 8.2 11.4 2.8 7.8 11.4 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4498 PF14926.6 EMC80522.1 - 3.3e-102 341.0 1.4 4e-102 340.8 1.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4498) CarbpepA_inh PF02977.15 EMC80522.1 - 1.6 8.6 4.7 0.88 9.4 0.3 2.5 2 0 0 2 2 2 0 Carboxypeptidase A inhibitor K1377 PF15352.6 EMC80523.1 - 2.5e-262 873.5 49.2 2.9e-262 873.3 49.2 1.0 1 0 0 1 1 1 1 Susceptibility to monomelic amyotrophy Fibrinogen_C PF00147.18 EMC80524.1 - 1.4e-58 198.3 1.8 2.1e-58 197.7 1.8 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF2201_N PF13203.6 EMC80525.1 - 0.018 14.6 11.5 0.043 13.4 11.5 1.6 1 1 0 1 1 1 0 Putative metallopeptidase domain SLC12 PF03522.15 EMC80525.1 - 0.029 13.4 31.7 0.031 13.3 31.7 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Zip PF02535.22 EMC80525.1 - 0.12 11.5 21.7 0.15 11.2 21.7 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 EMC80525.1 - 0.28 9.9 35.6 0.32 9.7 35.6 1.0 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 EMC80525.1 - 0.42 8.8 46.3 0.47 8.7 46.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EMC80525.1 - 0.61 8.2 50.3 0.66 8.1 50.3 1.0 1 0 0 1 1 1 0 Nop14-like family Velvet PF11754.8 EMC80525.1 - 3.6 7.4 10.1 4.6 7.1 10.1 1.2 1 0 0 1 1 1 0 Velvet factor SID-1_RNA_chan PF13965.6 EMC80525.1 - 4.6 5.5 15.3 6.6 5.0 15.3 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Smg8_Smg9 PF10220.9 EMC80525.1 - 8.1 4.6 30.8 9 4.5 30.8 1.0 1 0 0 1 1 1 0 Smg8_Smg9 Ion_trans PF00520.31 EMC80526.1 - 2e-34 118.9 17.8 3e-34 118.3 17.8 1.3 1 0 0 1 1 1 1 Ion transport protein TRP_2 PF08344.11 EMC80526.1 - 4.1e-27 94.2 1.0 8.1e-27 93.2 1.0 1.5 1 0 0 1 1 1 1 Transient receptor ion channel II PKD_channel PF08016.12 EMC80526.1 - 1.9e-14 53.2 13.8 3.3e-14 52.4 13.8 1.3 1 0 0 1 1 1 1 Polycystin cation channel Ank_2 PF12796.7 EMC80526.1 - 1.3e-10 41.8 1.6 3.8e-07 30.6 0.4 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC80526.1 - 1e-05 25.7 2.1 0.35 11.2 0.2 4.2 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC80526.1 - 8.7e-05 23.0 0.6 0.0092 16.5 0.0 3.5 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC80526.1 - 0.00056 20.2 4.0 9.7 7.1 0.1 5.3 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.30 EMC80526.1 - 0.031 14.7 3.8 10 6.8 0.0 3.6 2 1 1 3 3 3 0 Ankyrin repeat ING PF12998.7 EMC80526.1 - 0.049 14.2 7.6 1.1 9.9 5.1 2.7 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding 7tm_1 PF00001.21 EMC80526.1 - 1.9 7.8 6.6 4.1 6.6 6.6 1.5 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Baculo_11_kDa PF06143.11 EMC80526.1 - 8.9 6.0 6.8 1.7 8.2 0.8 2.4 2 0 0 2 2 2 0 Baculovirus 11 kDa family Hormone_recep PF00104.30 EMC80527.1 - 6.7e-28 97.7 7.3 1.1e-27 97.0 7.3 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 EMC80527.1 - 1.1e-26 93.0 15.7 1.1e-26 93.0 15.7 1.6 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Prog_receptor PF02161.15 EMC80527.1 - 0.00039 19.3 1.1 0.0005 18.9 1.1 1.1 1 0 0 1 1 1 1 Progesterone receptor DUF1422 PF07226.11 EMC80527.1 - 0.12 12.4 0.2 16 5.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1422) I-set PF07679.16 EMC80528.1 - 3.3e-75 248.2 0.0 4.3e-15 55.6 0.0 6.8 5 1 1 6 6 6 6 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC80528.1 - 5.9e-75 247.9 3.4 5.3e-13 49.4 0.0 7.6 8 0 0 8 8 7 6 Immunoglobulin domain Ig_2 PF13895.6 EMC80528.1 - 1.3e-53 179.3 0.8 5.6e-09 36.2 0.0 6.9 6 1 1 7 7 7 6 Immunoglobulin domain ig PF00047.25 EMC80528.1 - 1.1e-40 137.6 0.2 9.2e-08 32.2 0.0 6.8 6 0 0 6 6 6 6 Immunoglobulin domain fn3 PF00041.21 EMC80528.1 - 5.7e-37 125.9 3.7 2.2e-11 43.9 0.2 4.7 4 0 0 4 4 4 4 Fibronectin type III domain V-set PF07686.17 EMC80528.1 - 3e-27 94.9 4.0 0.00079 19.6 0.0 9.4 6 3 0 6 6 6 5 Immunoglobulin V-set domain Ig_6 PF18452.1 EMC80528.1 - 5.5e-14 51.5 0.0 0.0095 15.5 0.0 6.5 6 0 0 6 6 6 3 Immunoglobulin domain Ig_5 PF16681.5 EMC80528.1 - 1.5e-12 47.8 0.1 0.0083 16.5 0.0 6.3 6 1 0 6 6 6 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 EMC80528.1 - 3e-10 40.2 0.4 0.044 14.1 0.0 6.0 6 1 0 6 6 6 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 EMC80528.1 - 7.4e-09 35.6 2.4 0.81 9.8 0.0 6.0 6 0 0 6 6 6 2 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 EMC80528.1 - 8.5e-08 32.2 0.1 1.6 8.9 0.0 6.3 6 0 0 6 6 6 1 Izumo-like Immunoglobulin domain C2-set PF05790.15 EMC80528.1 - 7.6e-05 22.8 0.0 0.24 11.6 0.0 4.1 4 0 0 4 4 3 1 Immunoglobulin C2-set domain Herpes_gE PF02480.16 EMC80528.1 - 0.00022 20.1 0.1 2.3 6.9 0.0 3.9 4 1 1 5 5 5 2 Alphaherpesvirus glycoprotein E Pur_ac_phosph_N PF16656.5 EMC80528.1 - 0.001 19.6 0.3 1.1 9.9 0.0 3.1 3 0 0 3 3 2 1 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 EMC80528.1 - 0.052 13.9 0.0 2.5 8.5 0.0 3.2 3 0 0 3 3 3 0 Interferon-alpha/beta receptor, fibronectin type III C1-set PF07654.15 EMC80528.1 - 0.072 13.5 0.0 12 6.3 0.0 3.7 3 0 0 3 3 2 0 Immunoglobulin C1-set domain 7tm_2 PF00002.24 EMC80529.1 - 2.4e-30 105.7 20.1 3.3e-30 105.2 20.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 EMC80529.1 - 1.6e-08 35.0 4.2 3.3e-08 33.9 4.2 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif GAIN PF16489.5 EMC80529.1 - 0.061 12.7 0.5 0.7 9.3 0.6 2.1 1 1 1 2 2 2 0 GPCR-Autoproteolysis INducing (GAIN) domain SH3_9 PF14604.6 EMC80530.1 - 1.6e-45 152.7 4.2 4.8e-16 58.4 0.1 3.5 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.28 EMC80530.1 - 9.9e-41 137.1 7.2 2e-13 49.7 0.2 3.4 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.17 EMC80530.1 - 5.2e-37 125.3 4.5 7.7e-13 47.9 0.1 3.4 3 0 0 3 3 3 3 Variant SH3 domain Filament PF00038.21 EMC80530.1 - 0.0016 18.1 0.8 0.0026 17.4 0.8 1.3 1 0 0 1 1 1 1 Intermediate filament protein Golgin_A5 PF09787.9 EMC80530.1 - 0.0057 16.2 1.6 0.009 15.5 1.6 1.3 1 0 0 1 1 1 1 Golgin subfamily A member 5 betaPIX_CC PF16523.5 EMC80530.1 - 0.3 10.9 10.5 0.68 9.8 10.5 1.6 1 0 0 1 1 1 0 betaPIX coiled coil NRBF2 PF08961.10 EMC80530.1 - 0.54 9.8 8.8 1.8 8.2 8.8 1.8 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator DUF724 PF05266.14 EMC80530.1 - 1.1 9.0 6.4 2.2 8.1 6.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TNFR_c6 PF00020.18 EMC80531.1 - 7.5e-20 71.0 35.5 7.1e-07 29.5 7.0 5.2 5 0 0 5 5 5 4 TNFR/NGFR cysteine-rich region Death PF00531.22 EMC80531.1 - 6.7e-13 48.6 0.1 1.2e-12 47.8 0.1 1.4 1 0 0 1 1 1 1 Death domain Ephrin_rec_like PF07699.13 EMC80531.1 - 0.00015 21.5 25.3 0.0015 18.3 4.7 4.3 2 2 3 5 5 5 4 Putative ephrin-receptor like CARD PF00619.21 EMC80531.1 - 0.019 15.0 0.2 0.036 14.1 0.2 1.5 1 0 0 1 1 1 0 Caspase recruitment domain NCD3G PF07562.14 EMC80531.1 - 0.54 10.3 22.0 3.1 7.8 10.0 3.8 2 2 2 4 4 4 0 Nine Cysteines Domain of family 3 GPCR 7tm_2 PF00002.24 EMC80532.1 - 1.5e-34 119.4 22.4 2.7e-34 118.6 22.4 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 EMC80532.1 - 1.4e-15 57.5 3.3 7.6e-15 55.2 3.3 2.5 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Ig_3 PF13927.6 EMC80532.1 - 1.8e-13 50.8 15.1 3.9e-09 37.0 0.1 3.7 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 EMC80532.1 - 4e-13 49.2 2.9 1.6e-07 31.3 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 EMC80532.1 - 9.5e-13 48.1 16.9 1.2e-07 31.7 0.2 3.9 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 EMC80532.1 - 2.4e-08 34.2 19.5 4.6e-06 26.9 0.1 4.3 4 0 0 4 4 4 2 Immunoglobulin domain GAIN PF16489.5 EMC80532.1 - 2.7e-08 33.5 7.1 5.7e-08 32.5 7.1 1.5 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain SEA PF01390.20 EMC80532.1 - 4.2e-08 33.2 0.9 6.2e-07 29.5 0.1 3.3 3 1 0 3 3 3 1 SEA domain Izumo-Ig PF16706.5 EMC80532.1 - 0.00024 21.1 2.4 0.0091 16.0 0.0 3.8 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain V-set PF07686.17 EMC80532.1 - 0.00066 19.8 10.0 0.097 12.9 0.6 5.3 3 2 0 3 3 3 1 Immunoglobulin V-set domain DUF1772 PF08592.11 EMC80532.1 - 5.5 7.3 8.9 37 4.6 5.4 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) Astacin PF01400.24 EMC80533.1 - 2e-67 226.5 0.0 3.1e-67 225.9 0.0 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) MAM PF00629.23 EMC80533.1 - 1.1e-37 129.5 0.1 1.8e-37 128.7 0.1 1.4 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu EGF PF00008.27 EMC80533.1 - 4.9e-09 36.3 5.5 1.3e-08 34.9 5.5 1.8 1 0 0 1 1 1 1 EGF-like domain EGF_2 PF07974.13 EMC80533.1 - 0.71 10.3 13.0 0.25 11.7 8.6 2.5 2 0 0 2 2 2 0 EGF-like domain hEGF PF12661.7 EMC80533.1 - 2.4 8.9 9.0 0.73 10.6 5.6 2.1 2 0 0 2 2 2 0 Human growth factor-like EGF EGF_CA PF07645.15 EMC80533.1 - 2.8 8.2 11.8 0.24 11.7 6.7 1.9 2 0 0 2 2 2 0 Calcium-binding EGF domain EGF_3 PF12947.7 EMC80533.1 - 3.2 8.0 6.7 9.6 6.5 6.7 1.9 1 0 0 1 1 1 0 EGF domain Astacin PF01400.24 EMC80534.1 - 4.3e-14 52.6 0.0 5.9e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) TAS2R PF05296.13 EMC80535.1 - 1.3e-63 214.9 29.1 1.6e-63 214.7 29.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) UcrQ PF02939.16 EMC80535.1 - 0.68 9.9 2.6 8.4 6.4 0.1 3.3 3 0 0 3 3 3 0 UcrQ family Ni_hydr_CYTB PF01292.20 EMC80535.1 - 1.6 8.3 10.4 0.34 10.5 6.4 2.0 2 1 0 2 2 2 0 Prokaryotic cytochrome b561 DUF202 PF02656.15 EMC80535.1 - 4 8.0 8.2 0.86 10.1 3.5 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF202) Ank_4 PF13637.6 EMC80536.1 - 9.5e-19 67.5 1.0 6.3e-10 39.4 0.1 2.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC80536.1 - 2.4e-16 60.1 0.0 2e-14 54.0 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC80536.1 - 4.1e-13 48.2 0.2 0.00024 21.3 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EMC80536.1 - 3.7e-11 43.0 0.4 0.00013 22.2 0.0 3.3 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EMC80536.1 - 9.5e-09 35.3 1.8 0.00026 21.3 0.1 3.6 3 1 0 3 3 3 2 Ankyrin repeat Mito_carr PF00153.27 EMC80538.1 - 4.8e-67 221.9 0.4 3.3e-21 75.0 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein p450 PF00067.22 EMC80539.1 - 8.6e-58 196.2 0.1 1.5e-57 195.4 0.1 1.3 1 1 0 1 1 1 1 Cytochrome P450 Utp13 PF08625.11 EMC80539.1 - 0.16 11.9 0.0 0.29 11.0 0.0 1.3 1 0 0 1 1 1 0 Utp13 specific WD40 associated domain Calcipressin PF04847.12 EMC80540.1 - 4.2e-64 215.7 0.3 5.3e-64 215.4 0.3 1.1 1 0 0 1 1 1 1 Calcipressin RRM_1 PF00076.22 EMC80540.1 - 0.012 15.4 0.3 0.023 14.5 0.3 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMC80540.1 - 0.035 13.9 0.0 0.06 13.2 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif Phosphodiest PF01663.22 EMC80541.1 - 1.2e-71 242.3 1.9 1.4e-71 242.0 1.9 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EMC80541.1 - 0.00017 21.1 0.0 0.0065 15.9 0.0 2.4 2 1 0 2 2 2 1 Sulfatase DUF131 PF01998.17 EMC80541.1 - 0.036 13.7 1.8 0.074 12.7 1.8 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF131 Metalloenzyme PF01676.18 EMC80541.1 - 0.041 13.2 0.0 0.08 12.3 0.0 1.4 1 0 0 1 1 1 0 Metalloenzyme superfamily Phosphodiest PF01663.22 EMC80542.1 - 3e-84 283.7 0.8 3.5e-84 283.4 0.8 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EMC80542.1 - 6e-07 29.2 0.0 0.00032 20.2 0.0 2.3 1 1 0 2 2 2 2 Sulfatase Metalloenzyme PF01676.18 EMC80542.1 - 0.00031 20.2 0.0 0.00051 19.5 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily PglZ PF08665.12 EMC80542.1 - 0.084 13.0 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 PglZ domain TFIID-18kDa PF02269.16 EMC80543.1 - 3.1e-29 100.9 0.1 1.1e-28 99.1 0.3 1.9 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit Hit1_C PF18268.1 EMC80543.1 - 0.041 14.0 0.3 0.1 12.8 0.3 1.6 1 0 0 1 1 1 0 Hit1 C-terminal 7tm_4 PF13853.6 EMC80544.1 - 7.9e-13 48.8 1.0 1.1e-12 48.4 1.0 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC80544.1 - 5.4e-11 42.3 0.4 7.3e-11 41.9 0.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TNF PF00229.18 EMC80546.1 - 3.1e-38 130.6 0.1 4.9e-38 129.9 0.1 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family Voltage_CLC PF00654.20 EMC80548.1 - 2.6e-108 362.4 21.2 2.6e-108 362.4 21.2 1.7 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EMC80548.1 - 3.6e-15 56.1 2.3 2.1e-06 28.0 0.1 2.5 2 0 0 2 2 2 2 CBS domain RhoGAP PF00620.27 EMC80549.1 - 5e-32 110.8 0.0 9.6e-31 106.7 0.0 2.7 2 1 0 2 2 2 1 RhoGAP domain APC_N_CC PF16689.5 EMC80550.1 - 0.057 13.5 0.8 0.057 13.5 0.8 3.2 4 0 0 4 4 4 0 Coiled-coil N-terminus of APC, dimerisation domain 7tm_1 PF00001.21 EMC80551.1 - 2.9e-38 131.7 13.8 3.6e-38 131.4 13.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LAB_N PF07578.11 EMC80551.1 - 0.1 12.7 3.2 0.083 13.0 1.1 2.0 2 0 0 2 2 2 0 Lipid A Biosynthesis N-terminal domain Mito_carr PF00153.27 EMC80552.1 - 9.8e-29 99.1 0.2 6.8e-16 58.0 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein Ras PF00071.22 EMC80553.1 - 4.8e-50 169.3 0.0 5.6e-50 169.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC80553.1 - 5.4e-33 113.8 0.1 7.5e-33 113.3 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC80553.1 - 3.5e-15 55.9 0.0 4e-15 55.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EMC80553.1 - 2.2e-08 33.7 0.0 2.6e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMC80553.1 - 9.5e-08 32.1 0.0 1.4e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC80553.1 - 2e-06 27.5 1.0 0.00011 21.8 1.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EMC80553.1 - 1.1e-05 24.9 0.0 1.9e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EMC80553.1 - 0.00049 19.4 0.3 0.0033 16.6 0.2 2.2 1 1 1 2 2 2 1 G-protein alpha subunit PduV-EutP PF10662.9 EMC80553.1 - 0.023 14.4 0.0 0.045 13.5 0.0 1.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 EMC80553.1 - 0.052 13.0 0.0 0.083 12.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein FeoB_N PF02421.18 EMC80553.1 - 0.16 11.5 0.0 0.27 10.8 0.0 1.5 1 1 0 1 1 1 0 Ferrous iron transport protein B Ribosomal_S4e PF00900.20 EMC80554.1 - 2.3e-40 136.4 0.5 1.7e-39 133.6 0.5 2.1 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.5 EMC80554.1 - 1.6e-29 101.2 0.1 2.9e-29 100.4 0.1 1.4 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus S4 PF01479.25 EMC80554.1 - 3.5e-06 26.6 0.0 6.6e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 EMC80554.1 - 4e-06 26.6 0.2 1.9e-05 24.4 0.2 2.3 1 0 0 1 1 1 1 KOW motif RS4NT PF08071.12 EMC80554.1 - 0.0083 16.2 0.8 0.025 14.7 0.8 1.9 1 0 0 1 1 1 1 RS4NT (NUC023) domain Glyco_hydro_15 PF00723.21 EMC80555.1 - 1.8e-175 584.1 0.0 2.2e-175 583.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Lipase_C PF18067.1 EMC80555.1 - 0.033 14.8 0.0 3.1 8.4 0.0 2.6 2 0 0 2 2 2 0 Lipase C-terminal domain Cyclin_N PF00134.23 EMC80557.1 - 9e-08 31.9 0.1 1.4e-07 31.3 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Gal_Lectin PF02140.18 EMC80558.1 - 1.9e-37 127.6 4.2 4.3e-18 65.5 0.3 2.3 2 0 0 2 2 2 2 Galactose binding lectin domain FAM176 PF14851.6 EMC80558.1 - 5.4e-12 45.6 0.0 8.3e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 FAM176 family DUF3395 PF11875.8 EMC80558.1 - 0.015 15.2 0.0 5.1 7.0 0.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF3395) GST_C_2 PF13410.6 EMC80559.1 - 6.1e-07 29.4 0.0 1.1e-06 28.6 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EMC80559.1 - 2.9e-06 27.5 0.0 5.7e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EMC80559.1 - 0.00033 21.0 0.0 0.00058 20.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 EMC80559.1 - 0.0057 16.9 0.0 0.013 15.7 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin GST_C PF00043.25 EMC80559.1 - 0.014 15.6 0.0 0.042 14.1 0.0 1.8 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF1533 PF07550.11 EMC80559.1 - 0.058 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1533) GST_N_4 PF17172.4 EMC80559.1 - 0.13 13.0 0.1 0.67 10.7 0.1 2.1 2 1 0 2 2 2 0 Glutathione S-transferase N-terminal domain FerB PF08150.12 EMC80561.1 - 7.3e-17 61.7 0.0 7.7e-17 61.7 0.0 1.0 1 0 0 1 1 1 1 FerB (NUC096) domain C2 PF00168.30 EMC80562.1 - 2.5e-22 79.1 0.0 9.2e-15 54.8 0.0 3.3 3 0 0 3 3 3 3 C2 domain PTEN_C2 PF10409.9 EMC80562.1 - 0.042 13.6 0.0 0.07 12.9 0.0 1.3 1 0 0 1 1 1 0 C2 domain of PTEN tumour-suppressor protein Lectin_leg-like PF03388.13 EMC80563.1 - 2.1e-62 210.5 0.0 6.1e-62 209.0 0.0 1.6 1 1 0 1 1 1 1 Legume-like lectin family PMP1_2 PF08114.11 EMC80563.1 - 0.0039 16.9 0.2 0.0079 15.9 0.2 1.5 1 0 0 1 1 1 1 ATPase proteolipid family DUF4134 PF13572.6 EMC80563.1 - 0.04 14.2 0.1 0.066 13.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4134) Vpu PF00558.19 EMC80563.1 - 0.23 11.2 0.6 0.44 10.4 0.6 1.4 1 0 0 1 1 1 0 Vpu protein FAM178 PF14816.6 EMC80565.1 - 6.3e-43 147.2 0.5 9.1e-42 143.4 0.5 2.5 1 1 0 1 1 1 1 Family of unknown function, FAM178 START PF01852.19 EMC80566.1 - 6.3e-08 32.3 0.1 7.8e-08 32.0 0.1 1.1 1 0 0 1 1 1 1 START domain IL1 PF00340.19 EMC80567.1 - 4.9e-18 64.9 0.0 2.6e-09 36.8 0.0 2.4 2 0 0 2 2 2 2 Interleukin-1 / 18 PH_9 PF15410.6 EMC80567.1 - 1.5e-06 28.6 0.0 2.8e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain Bactofilin PF04519.13 EMC80567.1 - 0.014 15.7 0.0 29 5.0 0.0 4.1 2 1 1 3 3 3 0 Polymer-forming cytoskeletal PH PF00169.29 EMC80567.1 - 0.12 12.9 0.0 0.24 11.9 0.0 1.5 1 0 0 1 1 1 0 PH domain Sec7 PF01369.20 EMC80567.1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 Sec7 domain EMP24_GP25L PF01105.24 EMC80568.1 - 1.2e-44 152.4 0.0 1.3e-44 152.3 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD SdrD_B PF17210.3 EMC80568.1 - 0.052 13.8 0.0 0.079 13.2 0.0 1.3 1 0 0 1 1 1 0 SdrD B-like domain CarboxypepD_reg PF13620.6 EMC80568.1 - 0.14 12.5 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain Plectin PF00681.20 EMC80569.1 - 5.5e-55 183.0 0.0 1.4e-20 72.8 0.0 5.3 4 1 1 5 5 5 4 Plectin repeat An_peroxidase PF03098.15 EMC80570.1 - 1.1e-54 185.9 0.0 4.1e-48 164.3 0.0 2.3 1 1 1 2 2 2 2 Animal haem peroxidase EGF PF00008.27 EMC80570.1 - 2.9e-05 24.3 13.8 6e-05 23.2 13.8 1.6 1 0 0 1 1 1 1 EGF-like domain PLA2_B PF01735.18 EMC80572.1 - 5e-158 526.5 0.0 6.3e-158 526.2 0.0 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain C2 PF00168.30 EMC80572.1 - 3.5e-15 56.1 0.0 7e-15 55.2 0.0 1.5 1 0 0 1 1 1 1 C2 domain DUF2281 PF10047.9 EMC80572.1 - 0.0062 17.2 0.0 0.015 16.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2281) FANCAA PF15146.6 EMC80572.1 - 0.014 14.5 0.0 0.026 13.6 0.0 1.3 1 0 0 1 1 1 0 Fanconi anemia-associated EGF_CA PF07645.15 EMC80573.1 - 3.8e-12 46.2 8.0 3.8e-12 46.2 8.0 1.9 1 1 1 2 2 2 1 Calcium-binding EGF domain EGF_3 PF12947.7 EMC80573.1 - 0.024 14.8 3.8 0.024 14.8 3.8 1.9 2 0 0 2 2 2 0 EGF domain T-box PF00907.22 EMC80575.1 - 8.4e-86 286.9 0.1 1.1e-85 286.6 0.1 1.1 1 0 0 1 1 1 1 T-box TBX PF12598.8 EMC80575.1 - 1.2e-05 26.0 0.1 4.2e-05 24.3 0.1 2.0 1 0 0 1 1 1 1 T-box transcription factor Helicase_C_2 PF13307.6 EMC80576.1 - 5.1e-53 179.7 0.0 1e-52 178.8 0.0 1.5 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 EMC80576.1 - 3.4e-50 170.1 0.1 3.4e-50 170.1 0.1 2.1 2 0 0 2 2 2 1 DEAD_2 DEAD PF00270.29 EMC80576.1 - 0.00014 21.7 0.3 0.0024 17.7 0.3 2.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase HBB PF06777.11 EMC80576.1 - 0.00039 20.2 0.0 0.00078 19.2 0.0 1.4 1 0 0 1 1 1 1 Helical and beta-bridge domain ResIII PF04851.15 EMC80576.1 - 0.0013 18.8 0.0 0.27 11.2 0.0 2.8 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Med13_C PF06333.12 EMC80577.1 - 1.3e-118 396.1 0.1 1.3e-118 396.1 0.1 3.9 3 0 0 3 3 3 1 Mediator complex subunit 13 C-terminal domain MID_MedPIWI PF18296.1 EMC80577.1 - 4e-98 328.1 0.1 4e-98 328.1 0.1 2.8 3 0 0 3 3 3 1 MID domain of medPIWI Med13_N PF11597.8 EMC80577.1 - 2.8e-25 89.4 0.0 6.8e-25 88.1 0.0 1.7 1 0 0 1 1 1 1 Mediator complex subunit 13 N-terminal zf-C3HC4_3 PF13920.6 EMC80578.1 - 9.6e-11 41.4 7.1 1.7e-10 40.6 7.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC80578.1 - 6.6e-10 39.2 11.0 1.6e-09 38.0 11.0 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC80578.1 - 7.2e-10 38.5 10.7 1.4e-09 37.6 10.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC80578.1 - 3.2e-09 36.6 7.7 7.7e-09 35.4 7.7 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EMC80578.1 - 1.3e-08 34.5 11.3 2.6e-08 33.6 11.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC80578.1 - 1.5e-07 31.1 8.3 2.8e-07 30.3 8.3 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EMC80578.1 - 1.6e-07 31.1 9.5 3.5e-07 30.1 9.5 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EMC80578.1 - 3.9e-07 30.2 10.1 9.2e-07 29.1 10.1 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EMC80578.1 - 1.4e-05 25.2 11.1 2.8e-05 24.2 11.1 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 EMC80578.1 - 0.0013 18.5 2.8 0.0032 17.3 2.8 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 EMC80578.1 - 0.017 15.1 7.3 0.46 10.6 7.3 2.5 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EMC80578.1 - 0.054 13.1 5.6 0.11 12.2 5.6 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 EMC80578.1 - 0.31 10.8 8.0 0.83 9.5 8.0 1.8 1 0 0 1 1 1 0 RING-like zinc finger GAGA PF09237.11 EMC80578.1 - 0.67 9.8 3.3 8.3 6.3 0.0 2.3 2 0 0 2 2 2 0 GAGA factor zf-Nse PF11789.8 EMC80578.1 - 0.71 9.7 7.2 1.3 8.9 7.2 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit CTU2 PF10288.9 EMC80578.1 - 1.8 8.8 5.5 44 4.4 5.5 2.2 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 DZR PF12773.7 EMC80578.1 - 3.3 7.8 8.5 8.6 6.5 8.7 1.7 1 1 0 1 1 1 0 Double zinc ribbon zf-C3HC4_5 PF17121.5 EMC80578.1 - 3.5 7.6 8.9 64 3.5 8.9 3.0 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Pkinase PF00069.25 EMC80579.1 - 7.2e-70 235.4 0.0 1.3e-69 234.5 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC80579.1 - 5.2e-37 127.5 0.0 6.7e-37 127.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EMC80579.1 - 3e-10 40.7 3.7 7.4e-10 39.4 3.7 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 EMC80579.1 - 2.2e-07 30.5 0.0 6.6e-07 28.9 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EMC80579.1 - 0.00018 20.4 0.1 0.00028 19.8 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 EMC80579.1 - 0.036 13.7 0.1 5 6.7 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EMC80579.1 - 0.14 12.0 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EMC80579.1 - 0.19 10.6 0.1 0.28 10.1 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 EMC80579.1 - 0.25 10.7 0.2 0.4 10.0 0.2 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PTH2 PF01981.16 EMC80580.1 - 2.6e-48 163.2 0.0 2.8e-48 163.0 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 DUF2000 PF09391.10 EMC80580.1 - 0.025 14.5 0.4 0.86 9.5 0.2 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2000) HTH_ParB PF17762.1 EMC80580.1 - 0.097 12.5 0.2 0.63 9.9 0.0 2.0 2 0 0 2 2 2 0 HTH domain found in ParB protein Clathrin PF00637.20 EMC80581.1 - 1.2e-209 686.6 39.2 1.8e-34 118.7 1.4 7.9 7 1 1 8 8 8 7 Region in Clathrin and VPS Clathrin_propel PF01394.20 EMC80581.1 - 2.1e-48 160.3 3.4 3.1e-08 33.5 0.0 6.7 6 0 0 6 6 6 6 Clathrin propeller repeat Clathrin_H_link PF13838.6 EMC80581.1 - 1.1e-32 111.7 0.4 7.1e-32 109.1 0.3 2.6 2 0 0 2 2 2 1 Clathrin-H-link Clathrin-link PF09268.10 EMC80581.1 - 1e-14 53.5 0.7 3.1e-14 52.0 0.7 1.9 1 0 0 1 1 1 1 Clathrin, heavy-chain linker Coatomer_WDAD PF04053.14 EMC80581.1 - 1.6e-07 30.7 4.8 1.4e-05 24.4 0.3 4.0 4 0 0 4 4 4 1 Coatomer WD associated region TPR_7 PF13176.6 EMC80581.1 - 0.00011 22.0 11.4 1.5 9.1 0.1 8.1 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_19 PF14559.6 EMC80581.1 - 0.00043 20.7 3.9 4.1 8.0 0.1 6.0 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 EMC80581.1 - 0.0048 16.9 8.9 4.5 7.6 0.0 6.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 EMC80581.1 - 0.017 15.9 22.5 24 6.1 0.0 9.1 8 1 1 9 9 8 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC80581.1 - 0.04 14.1 3.1 12 6.2 0.1 5.3 5 0 0 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 EMC80581.1 - 0.098 12.5 13.9 0.27 11.1 0.0 6.0 6 0 0 6 6 5 0 Tetratricopeptide repeat Ovate PF04844.13 EMC80581.1 - 0.28 11.2 1.6 1.4 9.0 0.0 3.0 3 0 0 3 3 3 0 Transcriptional repressor, ovate HA2 PF04408.23 EMC80582.1 - 7.3e-15 55.2 1.7 1.1e-14 54.6 0.0 2.1 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EMC80582.1 - 5.5e-14 52.3 0.0 1e-13 51.4 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EMC80582.1 - 1.2e-13 51.4 0.0 2.7e-13 50.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4685 PF15737.5 EMC80582.1 - 0.00011 22.6 0.7 0.094 13.2 0.3 2.9 3 0 0 3 3 3 2 Domain of unknown function (DUF4685) DEAD PF00270.29 EMC80582.1 - 0.0011 18.7 0.0 0.0031 17.3 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase SesA PF17107.5 EMC80582.1 - 0.03 14.5 0.0 0.066 13.4 0.0 1.6 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Yippee-Mis18 PF03226.14 EMC80583.1 - 1.1e-12 48.0 0.2 1.5e-12 47.7 0.2 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly ATPgrasp_YheCD PF14398.6 EMC80583.1 - 0.0091 15.3 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 YheC/D like ATP-grasp RIG-I_C-RD PF11648.8 EMC80583.1 - 0.034 14.4 0.4 0.069 13.4 0.4 1.5 1 1 0 1 1 1 0 C-terminal domain of RIG-I Evr1_Alr PF04777.13 EMC80583.1 - 0.072 13.6 2.4 0.26 11.8 0.5 2.0 1 1 0 2 2 2 0 Erv1 / Alr family zf-CHY PF05495.12 EMC80583.1 - 0.094 13.2 7.3 0.41 11.2 7.3 1.9 1 1 0 1 1 1 0 CHY zinc finger Elf1 PF05129.13 EMC80583.1 - 0.1 12.7 0.9 4.6 7.3 0.1 2.2 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like GDPD PF03009.17 EMC80584.1 - 3.5e-24 85.9 0.1 1.2e-16 61.2 0.1 2.0 2 0 0 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 EMC80584.1 - 0.004 17.6 0.0 0.0075 16.7 0.0 1.5 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Smg8_Smg9 PF10220.9 EMC80585.1 - 0 1139.3 0.0 0 1139.0 0.0 1.0 1 0 0 1 1 1 1 Smg8_Smg9 SKA2 PF16740.5 EMC80586.1 - 3.2e-30 104.1 3.1 3.7e-30 103.9 3.1 1.0 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 2 Vps54_N PF10475.9 EMC80586.1 - 0.018 14.4 0.8 0.018 14.3 0.8 1.1 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex zf-B_box PF00643.24 EMC80587.1 - 6.8e-09 35.7 8.7 6.8e-09 35.7 8.7 3.0 2 1 1 3 3 2 1 B-box zinc finger MATH PF00917.26 EMC80587.1 - 3.6e-08 33.5 0.0 1.1e-07 32.0 0.0 1.9 1 0 0 1 1 1 1 MATH domain zf-C3HC4_3 PF13920.6 EMC80587.1 - 1.9e-05 24.4 15.1 1.9e-05 24.4 15.1 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC80587.1 - 0.0034 17.2 17.1 0.0034 17.2 17.1 2.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) HlyD_2 PF12700.7 EMC80587.1 - 0.012 14.4 4.7 0.021 13.6 4.7 1.3 1 0 0 1 1 1 0 HlyD family secretion protein Baculo_PEP_C PF04513.12 EMC80587.1 - 0.067 13.2 5.1 1.1 9.3 2.0 3.2 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus FUSC PF04632.12 EMC80587.1 - 0.13 10.7 2.8 0.26 9.8 2.8 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family MRFAP1 PF15155.6 EMC80587.1 - 0.31 11.6 4.5 0.16 12.5 1.4 2.1 2 0 0 2 2 2 0 MORF4 family-associated protein1 HTH_1 PF00126.27 EMC80587.1 - 0.37 10.8 1.4 4.9 7.2 0.2 2.5 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family PIN_8 PF18476.1 EMC80587.1 - 0.57 10.0 7.2 0.16 11.8 1.9 2.5 3 0 0 3 3 3 0 PIN like domain DUF148 PF02520.17 EMC80587.1 - 0.81 9.8 9.1 0.96 9.6 2.3 3.0 3 0 0 3 3 3 0 Domain of unknown function DUF148 DUF2203 PF09969.9 EMC80587.1 - 2.2 9.0 5.6 28 5.4 2.6 3.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF5071 PF16804.5 EMC80587.1 - 2.5 8.4 5.3 10 6.4 3.4 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF5071) Spc7 PF08317.11 EMC80587.1 - 9.7 5.0 16.3 33 3.2 0.1 2.7 2 1 0 2 2 2 0 Spc7 kinetochore protein PP2C PF00481.21 EMC80588.1 - 6e-64 216.2 0.2 7.6e-64 215.8 0.2 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EMC80588.1 - 0.003 17.2 0.2 0.0078 15.9 0.2 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EMC80588.1 - 0.017 15.0 0.7 1.4 8.8 0.1 2.3 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) Rad51 PF08423.11 EMC80589.1 - 1.1e-44 152.7 0.0 1.9e-44 151.9 0.0 1.3 1 1 0 1 1 1 1 Rad51 AAA_25 PF13481.6 EMC80589.1 - 1e-06 28.5 0.0 3e-06 27.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain RecA PF00154.21 EMC80589.1 - 9.6e-05 22.0 0.2 0.00034 20.2 0.2 1.9 2 0 0 2 2 2 1 recA bacterial DNA recombination protein ATPase PF06745.13 EMC80589.1 - 0.00022 20.7 0.4 0.0005 19.5 0.1 1.7 1 1 1 2 2 2 1 KaiC AAA_24 PF13479.6 EMC80589.1 - 0.007 16.1 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 EMC80589.1 - 0.01 15.2 0.0 0.018 14.4 0.0 1.4 1 1 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_18 PF13238.6 EMC80589.1 - 0.017 15.7 0.0 0.036 14.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EMC80589.1 - 0.02 15.3 0.2 0.076 13.4 0.1 2.0 2 1 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 EMC80589.1 - 0.05 13.9 0.5 0.5 10.6 0.0 2.8 3 1 1 4 4 4 0 AAA domain NACHT PF05729.12 EMC80589.1 - 0.06 13.3 0.1 0.14 12.1 0.1 1.6 1 1 0 1 1 1 0 NACHT domain AAA PF00004.29 EMC80589.1 - 0.093 13.2 0.1 0.45 10.9 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EMC80589.1 - 0.12 12.5 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EMC80589.1 - 0.12 12.6 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EMC80589.1 - 0.16 12.4 0.0 0.46 10.9 0.0 1.7 2 0 0 2 2 2 0 RNA helicase 7tm_1 PF00001.21 EMC80590.1 - 1.4e-47 162.3 11.7 1.7e-47 162.0 11.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 EMC80590.1 - 3.7e-10 39.6 10.4 5e-10 39.2 10.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 EMC80590.1 - 8.7e-08 32.2 5.8 5.9e-05 22.9 0.6 2.1 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srw PF10324.9 EMC80590.1 - 3.5e-07 29.8 3.6 3.5e-07 29.8 3.6 2.3 3 0 0 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.9 EMC80590.1 - 1.8e-06 27.5 12.3 5.9e-06 25.9 12.3 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TAS2R PF05296.13 EMC80590.1 - 0.0066 15.6 13.1 0.0079 15.3 2.6 2.1 2 0 0 2 2 2 2 Taste receptor protein (TAS2R) Cytochrom_B_N_2 PF13631.6 EMC80590.1 - 0.0088 16.1 0.8 0.019 15.0 0.2 1.8 2 0 0 2 2 2 1 Cytochrome b(N-terminal)/b6/petB 7TM_GPCR_Srh PF10318.9 EMC80590.1 - 0.16 10.9 13.0 0.0092 15.1 7.5 1.6 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srh DHHC PF01529.20 EMC80590.1 - 9.2 6.4 11.7 0.29 11.2 2.8 2.4 2 1 0 2 2 2 0 DHHC palmitoyltransferase C2 PF00168.30 EMC80591.1 - 8e-42 141.7 0.0 1.7e-24 86.1 0.0 2.5 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.16 EMC80591.1 - 4.7e-35 120.4 4.5 1e-34 119.3 4.5 1.6 1 0 0 1 1 1 1 FYVE-type zinc finger zf-piccolo PF05715.13 EMC80591.1 - 0.00018 21.6 8.2 0.00044 20.3 8.2 1.7 1 0 0 1 1 1 1 Piccolo Zn-finger IBR PF01485.21 EMC80591.1 - 0.071 13.3 3.4 0.094 13.0 1.3 2.3 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain PHD PF00628.29 EMC80591.1 - 0.16 11.9 8.2 0.38 10.7 8.2 1.7 1 0 0 1 1 1 0 PHD-finger Zn_Tnp_IS91 PF14319.6 EMC80591.1 - 0.18 11.8 4.9 0.15 12.1 2.7 2.0 1 1 0 1 1 1 0 Transposase zinc-binding domain DUF5401 PF17380.2 EMC80591.1 - 0.26 9.3 3.2 0.4 8.7 3.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5401) zf-B_box PF00643.24 EMC80591.1 - 1.8 8.8 8.9 0.24 11.6 3.9 2.1 1 1 1 2 2 2 0 B-box zinc finger C1_1 PF00130.22 EMC80591.1 - 2.2 8.3 10.9 0.76 9.7 5.6 2.4 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Vps53_N PF04100.12 EMC80593.1 - 1.5e-134 448.7 2.6 7.5e-106 354.3 1.7 2.4 2 0 0 2 2 2 2 Vps53-like, N-terminal Vps54_N PF10475.9 EMC80593.1 - 7.5e-07 28.7 2.3 7.5e-07 28.7 2.3 2.4 4 0 0 4 4 4 1 Vacuolar-sorting protein 54, of GARP complex VPS53_C PF16854.5 EMC80593.1 - 3.1e-05 24.0 0.4 0.001 19.0 0.0 2.7 2 0 0 2 2 2 1 Vacuolar protein sorting-associated protein 53 C-terminus Spc7 PF08317.11 EMC80593.1 - 5.6e-05 22.2 3.0 0.00011 21.2 3.0 1.4 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF2451 PF10474.9 EMC80593.1 - 0.0052 16.6 0.2 0.017 14.9 0.2 1.9 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) DUF4413 PF14372.6 EMC80593.1 - 0.0092 16.3 0.5 0.12 12.7 0.0 3.1 3 1 0 3 3 2 1 Domain of unknown function (DUF4413) DUF1664 PF07889.12 EMC80593.1 - 0.01 15.8 6.8 0.81 9.7 2.8 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 EMC80593.1 - 0.015 15.3 4.9 0.02 14.9 3.1 2.0 2 0 0 2 2 2 0 Laminin Domain II NBD94 PF16830.5 EMC80593.1 - 0.018 15.4 3.0 0.043 14.2 3.0 1.6 1 0 0 1 1 1 0 Nucleotide-Binding Domain 94 of RH Sec8_exocyst PF04048.14 EMC80593.1 - 0.019 14.9 2.1 0.025 14.5 0.7 1.9 2 0 0 2 2 1 0 Sec8 exocyst complex component specific domain Vps51 PF08700.11 EMC80593.1 - 0.025 14.7 4.5 0.063 13.4 0.0 3.3 3 0 0 3 3 2 0 Vps51/Vps67 XhlA PF10779.9 EMC80593.1 - 0.028 14.6 4.3 0.061 13.5 1.5 2.6 2 0 0 2 2 2 0 Haemolysin XhlA LXG PF04740.12 EMC80593.1 - 0.037 13.7 2.5 0.13 12.0 2.5 1.9 1 1 0 1 1 1 0 LXG domain of WXG superfamily Tropomyosin PF00261.20 EMC80593.1 - 0.039 13.3 2.3 0.067 12.5 1.1 2.0 2 0 0 2 2 2 0 Tropomyosin GrpE PF01025.19 EMC80593.1 - 0.045 13.4 1.8 0.12 12.1 1.8 1.7 1 0 0 1 1 1 0 GrpE ING PF12998.7 EMC80593.1 - 0.15 12.7 5.0 0.22 12.2 3.6 2.0 2 0 0 2 2 1 0 Inhibitor of growth proteins N-terminal histone-binding Sec34 PF04136.15 EMC80593.1 - 0.16 11.9 3.0 0.56 10.1 2.2 2.3 2 0 0 2 2 2 0 Sec34-like family APG17 PF04108.12 EMC80593.1 - 0.18 10.9 3.0 0.41 9.7 0.8 2.3 2 0 0 2 2 2 0 Autophagy protein Apg17 BRE1 PF08647.11 EMC80593.1 - 0.22 11.6 3.7 0.72 10.0 3.7 1.8 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase CREPT PF16566.5 EMC80593.1 - 0.26 11.5 3.3 2.8 8.1 1.2 3.1 2 1 1 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour Seryl_tRNA_N PF02403.22 EMC80593.1 - 0.35 11.1 4.8 0.88 9.8 2.7 2.6 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain COG5 PF10392.9 EMC80593.1 - 0.44 10.7 3.0 0.35 11.0 0.8 2.1 2 0 0 2 2 1 0 Golgi transport complex subunit 5 COG2 PF06148.11 EMC80593.1 - 0.49 10.5 5.7 2.1 8.4 2.5 3.3 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 BLOC1_2 PF10046.9 EMC80593.1 - 0.61 10.4 5.2 1.6 9.1 1.9 3.2 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF16 PF01519.16 EMC80593.1 - 1.2 9.6 9.0 2.9 8.4 3.3 3.6 1 1 2 3 3 3 0 Protein of unknown function DUF16 Syntaxin_2 PF14523.6 EMC80593.1 - 1.4 9.3 7.5 5.9 7.3 5.1 3.2 2 1 0 2 2 2 0 Syntaxin-like protein AAA_13 PF13166.6 EMC80593.1 - 1.6 7.3 5.6 0.33 9.6 1.5 1.8 2 0 0 2 2 2 0 AAA domain Prefoldin PF02996.17 EMC80593.1 - 2.2 8.2 5.9 24 4.9 0.1 3.5 2 1 2 4 4 4 0 Prefoldin subunit HrpB7 PF09486.10 EMC80593.1 - 2.4 8.5 6.0 1.2 9.5 2.5 2.2 2 1 1 3 3 2 0 Bacterial type III secretion protein (HrpB7) TRAM_LAG1_CLN8 PF03798.16 EMC80594.1 - 1.8e-40 138.8 13.6 2e-40 138.6 13.6 1.0 1 0 0 1 1 1 1 TLC domain SpoU_methylase PF00588.19 EMC80596.1 - 2.9e-23 82.6 0.0 1.2e-21 77.4 0.0 2.2 1 1 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 EMC80596.1 - 0.00086 19.5 0.0 0.0027 18.0 0.0 1.9 2 0 0 2 2 2 1 RNA 2'-O ribose methyltransferase substrate binding Thioredoxin_8 PF13905.6 EMC80597.1 - 3.1e-33 114.0 0.0 1.7e-29 102.0 0.0 2.8 3 0 0 3 3 3 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EMC80597.1 - 4.3e-12 46.4 0.0 8.9e-09 35.8 0.0 2.6 3 0 0 3 3 3 2 Thioredoxin-like domain AhpC-TSA PF00578.21 EMC80597.1 - 5e-09 36.1 0.0 1.2e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin PF00085.20 EMC80597.1 - 1.2e-08 34.9 0.0 2.6e-05 24.1 0.0 3.5 3 1 1 4 4 4 1 Thioredoxin Thioredoxin_6 PF13848.6 EMC80597.1 - 7.3e-08 32.5 0.1 4.5e-07 30.0 0.0 2.2 3 0 0 3 3 3 1 Thioredoxin-like domain Redoxin PF08534.10 EMC80597.1 - 2.7e-07 30.4 0.0 5.3e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Redoxin Thioredoxin_7 PF13899.6 EMC80597.1 - 5e-06 26.6 0.0 0.00013 22.0 0.0 3.0 2 1 0 2 2 2 1 Thioredoxin-like SCO1-SenC PF02630.14 EMC80597.1 - 3.9e-05 23.6 0.0 0.0002 21.3 0.0 2.0 2 0 0 2 2 2 1 SCO1/SenC HyaE PF07449.11 EMC80597.1 - 0.00033 20.6 0.1 4.1 7.4 0.0 3.9 4 0 0 4 4 4 1 Hydrogenase-1 expression protein HyaE Glutaredoxin PF00462.24 EMC80597.1 - 0.00064 19.9 0.0 0.0069 16.6 0.1 2.5 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin_9 PF14595.6 EMC80597.1 - 0.052 13.3 0.0 8 6.2 0.0 3.4 3 1 0 3 3 3 0 Thioredoxin MatE PF01554.18 EMC80599.1 - 4e-51 172.9 29.5 9.6e-29 100.1 10.5 2.3 2 0 0 2 2 2 2 MatE E1-E2_ATPase PF00122.20 EMC80599.1 - 8.6 5.8 18.6 0.014 14.9 4.0 3.2 2 2 2 4 4 4 0 E1-E2 ATPase WW PF00397.26 EMC80600.1 - 8.9e-08 32.1 0.2 1.9e-07 31.1 0.2 1.6 1 0 0 1 1 1 1 WW domain PMP22_Claudin PF00822.20 EMC80601.1 - 6.3e-24 84.7 0.9 8e-24 84.4 0.9 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC80601.1 - 9.2e-07 28.8 5.2 2.2e-05 24.3 5.2 2.2 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Clc-like PF07062.12 EMC80601.1 - 0.045 13.2 0.2 0.084 12.3 0.2 1.4 1 0 0 1 1 1 0 Clc-like XTBD PF11952.8 EMC80602.1 - 5.1e-20 71.0 0.0 1.4e-17 63.2 0.0 2.6 2 0 0 2 2 2 2 XRN-Two Binding Domain, XTBD Ish1 PF10281.9 EMC80602.1 - 0.087 13.1 0.1 0.27 11.6 0.1 1.9 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein ING PF12998.7 EMC80603.1 - 2e-12 47.6 3.3 2e-12 47.6 3.3 1.7 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EMC80603.1 - 2.9e-06 27.0 7.6 2.9e-06 27.0 7.6 2.3 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.6 EMC80603.1 - 0.0027 17.2 2.8 0.0073 15.8 2.8 1.7 1 0 0 1 1 1 1 PHD-finger zf-RING-like PF08746.11 EMC80603.1 - 0.011 16.0 4.9 0.16 12.3 2.6 2.7 2 0 0 2 2 2 0 RING-like domain zf-HC5HC2H PF13771.6 EMC80603.1 - 0.74 10.1 8.3 0.19 12.0 4.3 2.2 2 1 0 2 2 2 0 PHD-like zinc-binding domain Foie-gras_1 PF11817.8 EMC80604.1 - 4.2e-76 256.0 0.7 7.2e-76 255.2 0.7 1.4 1 0 0 1 1 1 1 Foie gras liver health family 1 Gryzun-like PF12742.7 EMC80604.1 - 4.8e-23 80.9 0.1 2.7e-22 78.5 0.1 2.1 2 0 0 2 2 2 1 Gryzun, putative Golgi trafficking Gryzun PF07919.12 EMC80604.1 - 9.6e-11 41.1 0.0 1.1e-08 34.4 0.1 2.2 2 0 0 2 2 2 2 Gryzun, putative trafficking through Golgi Prefoldin PF02996.17 EMC80604.1 - 0.067 13.1 0.1 0.36 10.8 0.1 2.2 1 0 0 1 1 1 0 Prefoldin subunit Phosphodiest PF01663.22 EMC80605.1 - 5.7e-75 253.1 0.6 6.6e-75 252.9 0.6 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 EMC80605.1 - 0.0015 17.9 0.0 0.0022 17.4 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 EMC80605.1 - 0.0075 15.7 0.1 0.015 14.7 0.0 1.6 2 0 0 2 2 2 1 Sulfatase PglZ PF08665.12 EMC80605.1 - 0.016 15.3 0.8 0.027 14.6 0.1 1.7 2 0 0 2 2 2 0 PglZ domain DUF229 PF02995.17 EMC80605.1 - 0.12 11.0 0.0 0.15 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) IRF PF00605.17 EMC80606.1 - 4.1e-42 142.7 1.0 7.5e-42 141.9 1.0 1.4 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor Heme_oxygenase PF01126.20 EMC80606.1 - 0.082 12.7 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Heme oxygenase Peptidase_C14 PF00656.22 EMC80607.1 - 2.2e-53 181.8 0.0 2.6e-53 181.5 0.0 1.0 1 0 0 1 1 1 1 Caspase domain Tachystatin_B PF11478.8 EMC80607.1 - 0.11 12.5 1.1 0.34 10.9 0.3 2.2 2 0 0 2 2 2 0 Antimicrobial chitin binding protein tachystatin B CENP-U PF13097.6 EMC80608.1 - 1.3e-49 168.6 5.5 1.3e-49 168.6 5.5 1.6 2 0 0 2 2 2 1 CENP-A nucleosome associated complex (NAC) subunit DUF4201 PF13870.6 EMC80608.1 - 0.0037 17.0 7.6 0.0092 15.7 7.6 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) GAS PF13851.6 EMC80608.1 - 0.0079 15.6 12.6 0.0079 15.6 12.6 2.1 2 1 1 3 3 3 1 Growth-arrest specific micro-tubule binding DUF1380 PF07128.12 EMC80608.1 - 0.03 14.5 0.0 0.059 13.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1380) SseC PF04888.12 EMC80608.1 - 0.033 13.8 0.3 0.072 12.7 0.3 1.6 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Sec8_exocyst PF04048.14 EMC80608.1 - 0.41 10.5 6.2 1.9 8.3 5.8 2.2 1 1 0 1 1 1 0 Sec8 exocyst complex component specific domain FliJ PF02050.16 EMC80608.1 - 0.51 10.6 9.5 1.6 8.9 8.2 2.6 1 1 1 2 2 2 0 Flagellar FliJ protein MCD_N PF17408.2 EMC80608.1 - 2 8.6 6.5 2.9 8.1 4.0 2.6 2 2 1 3 3 3 0 Malonyl-CoA decarboxylase N-terminal domain TMF_TATA_bd PF12325.8 EMC80608.1 - 2.4 8.4 11.4 14 6.0 5.9 2.6 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding V_ATPase_I PF01496.19 EMC80608.1 - 3 5.6 9.4 0.92 7.3 6.0 1.6 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Mod_r PF07200.13 EMC80608.1 - 3.3 7.8 15.5 0.34 11.0 9.2 2.4 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein NPV_P10 PF05531.12 EMC80608.1 - 4 8.0 5.8 20 5.8 2.6 2.9 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein BRE1 PF08647.11 EMC80608.1 - 4.5 7.4 15.2 0.7 10.0 10.2 2.2 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase OmpH PF03938.14 EMC80608.1 - 5.1 7.4 11.7 8.5 6.7 10.9 1.8 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) AMP-binding PF00501.28 EMC80609.1 - 1.6e-98 330.1 0.0 2.1e-98 329.7 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMC80609.1 - 7.7e-06 26.8 0.2 3.4e-05 24.7 0.1 2.1 1 1 1 2 2 2 1 AMP-binding enzyme C-terminal domain HLH PF00010.26 EMC80610.1 - 3.4e-13 49.3 0.0 8e-13 48.1 0.0 1.6 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 EMC80610.1 - 1.5e-08 34.7 0.8 6.4e-08 32.7 0.3 2.2 2 0 0 2 2 2 1 Hairy Orange Mito_carr PF00153.27 EMC80611.1 - 8e-58 192.4 4.4 6.1e-24 83.8 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Fuseless PF15993.5 EMC80611.1 - 0.028 13.6 0.1 0.24 10.6 0.0 2.0 2 0 0 2 2 2 0 Fuseless Sel1 PF08238.12 EMC80612.1 - 5.9e-30 103.0 15.0 9.2e-06 26.2 0.0 6.1 6 0 0 6 6 6 5 Sel1 repeat TPR_6 PF13174.6 EMC80612.1 - 0.0053 17.3 10.4 7.3 7.5 0.0 5.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMC80612.1 - 0.12 12.6 10.5 2.7 8.4 0.1 5.7 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 EMC80612.1 - 1 9.3 10.7 2.2 8.2 0.1 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 EMC80612.1 - 6.9 7.0 21.4 1.8 8.8 0.1 6.8 8 0 0 8 8 8 0 Tetratricopeptide repeat Ank_4 PF13637.6 EMC80613.1 - 9.5e-07 29.3 0.3 0.011 16.3 0.0 2.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC80613.1 - 1e-06 29.2 0.1 2.3e-06 28.1 0.1 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC80613.1 - 2.2e-05 24.6 0.5 0.0001 22.5 0.1 1.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EMC80613.1 - 2.3e-05 24.6 0.3 0.037 14.5 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 EMC80613.1 - 0.068 13.8 0.1 6.7 7.6 0.0 2.6 2 0 0 2 2 2 0 Ankyrin repeat Peptidase_C78 PF07910.13 EMC80614.1 - 4.4e-53 179.9 0.1 5.2e-53 179.7 0.1 1.0 1 0 0 1 1 1 1 Peptidase family C78 Peptidase_C54 PF03416.19 EMC80614.1 - 0.094 12.1 0.4 0.34 10.3 0.1 1.9 2 0 0 2 2 2 0 Peptidase family C54 DUF4586 PF15239.6 EMC80615.1 - 2.7e-113 379.2 5.8 3.1e-113 379.0 5.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4586) DUF4749 PF15936.5 EMC80616.1 - 3.1e-26 92.3 0.4 5.1e-26 91.7 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) PDZ PF00595.24 EMC80616.1 - 9.9e-16 57.9 0.0 2.3e-15 56.7 0.0 1.7 1 0 0 1 1 1 1 PDZ domain LIM PF00412.22 EMC80616.1 - 7.6e-14 51.7 2.7 1.2e-13 51.0 2.7 1.4 1 0 0 1 1 1 1 LIM domain PDZ_6 PF17820.1 EMC80616.1 - 4.5e-07 29.6 0.0 7.7e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC80616.1 - 0.0019 18.5 0.0 0.0052 17.1 0.0 1.7 1 0 0 1 1 1 1 PDZ domain Lar_restr_allev PF14354.6 EMC80616.1 - 0.14 12.6 1.7 0.31 11.5 1.7 1.6 1 0 0 1 1 1 0 Restriction alleviation protein Lar SH3_1 PF00018.28 EMC80617.1 - 6.8e-43 144.1 0.2 3.5e-14 52.1 0.0 3.5 3 0 0 3 3 3 3 SH3 domain SH3_9 PF14604.6 EMC80617.1 - 6.2e-40 134.8 1.0 1.2e-14 53.9 0.1 4.2 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.17 EMC80617.1 - 2.7e-29 100.6 0.8 9.8e-14 50.8 0.0 3.5 3 0 0 3 3 3 3 Variant SH3 domain Sorb PF02208.16 EMC80617.1 - 9.5e-26 89.4 3.3 3.1e-22 78.2 0.2 2.7 2 0 0 2 2 2 2 Sorbin homologous domain LRR_8 PF13855.6 EMC80618.1 - 3.1e-85 279.9 175.7 5.9e-13 48.4 1.9 11.7 2 2 11 14 14 14 14 Leucine rich repeat LRR_4 PF12799.7 EMC80618.1 - 2.3e-33 113.6 110.2 8.4e-05 22.9 1.1 13.3 6 3 10 17 17 17 14 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC80618.1 - 9.2e-27 93.5 26.6 2.6e-10 40.3 2.6 6.0 2 1 2 5 5 5 5 BspA type Leucine rich repeat region (6 copies) Tlr3_TMD PF17968.1 EMC80618.1 - 2.9e-17 62.5 3.4 7.2e-17 61.3 3.4 1.7 1 0 0 1 1 1 1 Toll-like receptor 3 trans-membrane domain LRR_9 PF14580.6 EMC80618.1 - 4e-12 46.0 36.6 0.0011 18.5 0.5 6.7 1 1 6 7 7 7 5 Leucine-rich repeat TIR PF01582.20 EMC80618.1 - 1.3e-11 44.7 3.6 1.9e-11 44.1 3.6 1.3 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.6 EMC80618.1 - 5.9e-08 33.3 0.3 1.8e-07 31.7 0.3 1.8 1 0 0 1 1 1 1 TIR domain LRR_1 PF00560.33 EMC80618.1 - 5.6e-05 23.2 97.6 0.33 11.7 0.3 20.8 21 3 0 21 21 21 4 Leucine Rich Repeat LRRNT PF01462.18 EMC80618.1 - 0.0025 17.4 0.0 0.014 15.0 0.0 2.3 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_3 PF07725.12 EMC80618.1 - 0.084 12.8 2.5 18 5.4 0.0 4.7 3 0 0 3 3 3 0 Leucine Rich Repeat DUF3719 PF12516.8 EMC80619.1 - 1.8e-23 82.0 0.1 9.9e-23 79.6 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3719) p450 PF00067.22 EMC80620.1 - 4.7e-94 315.8 0.0 5.2e-94 315.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peripla_BP_1 PF00532.21 EMC80620.1 - 0.057 12.8 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Periplasmic binding proteins and sugar binding domain of LacI family Trypsin PF00089.26 EMC80621.1 - 3.4e-73 246.1 0.0 5.2e-73 245.5 0.0 1.3 1 0 0 1 1 1 1 Trypsin PAN_1 PF00024.26 EMC80621.1 - 1.1e-27 95.8 36.4 2.1e-08 34.0 1.2 4.9 5 0 0 5 5 5 4 PAN domain PAN_4 PF14295.6 EMC80621.1 - 2.4e-15 56.2 24.7 9.7e-06 25.4 1.1 5.8 5 1 1 6 6 6 4 PAN domain Trypsin_2 PF13365.6 EMC80621.1 - 1.2e-06 29.4 0.0 2.6e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 EMC80621.1 - 0.00023 21.5 0.2 0.00049 20.5 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Cadherin PF00028.17 EMC80622.1 - 0 1697.7 100.5 9.1e-24 83.7 0.4 34.3 34 0 0 34 34 34 34 Cadherin domain Laminin_G_2 PF02210.24 EMC80622.1 - 4.7e-28 98.3 0.3 2.8e-27 95.8 0.3 2.5 1 0 0 1 1 1 1 Laminin G domain Cadherin_3 PF16184.5 EMC80622.1 - 5.9e-25 87.4 62.8 0.011 15.7 0.1 21.0 22 0 0 22 22 22 8 Cadherin-like Cadherin_2 PF08266.12 EMC80622.1 - 3.9e-21 74.7 6.4 3.4 7.6 0.0 19.2 22 0 0 22 22 22 1 Cadherin-like Laminin_G_1 PF00054.23 EMC80622.1 - 1e-18 67.8 0.0 4.9e-18 65.6 0.0 2.3 1 0 0 1 1 1 1 Laminin G domain EGF PF00008.27 EMC80622.1 - 5.7e-18 64.9 75.9 4.7e-07 30.0 5.2 5.8 6 0 0 6 6 5 4 EGF-like domain RET_CLD1 PF17756.1 EMC80622.1 - 1.8e-14 54.1 0.9 1.7 9.0 0.0 11.4 9 2 1 11 11 11 3 RET Cadherin like domain 1 Cadherin_pro PF08758.11 EMC80622.1 - 5.8e-10 39.2 0.5 2.6 8.3 0.0 12.4 13 0 0 13 13 13 1 Cadherin prodomain like EGF_CA PF07645.15 EMC80622.1 - 9.9e-06 25.7 10.7 9.9e-06 25.7 10.7 5.5 4 1 1 5 5 5 1 Calcium-binding EGF domain Y_Y_Y PF07495.13 EMC80622.1 - 0.00014 21.7 4.4 65 3.6 0.0 10.2 12 0 0 12 12 11 0 Y_Y_Y domain hEGF PF12661.7 EMC80622.1 - 0.0014 19.2 1.6 0.0014 19.2 1.6 6.1 6 0 0 6 6 6 3 Human growth factor-like EGF Laminin_G_3 PF13385.6 EMC80622.1 - 0.023 14.9 0.1 0.11 12.7 0.1 2.2 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily Cadherin_4 PF17803.1 EMC80622.1 - 0.028 15.0 112.3 0.38 11.4 5.6 19.3 20 0 0 20 20 18 0 Bacterial cadherin-like domain MBF2 PF15868.5 EMC80622.1 - 1.5 9.4 6.7 12 6.5 0.0 6.3 7 0 0 7 7 5 0 Transcription activator MBF2 MRP-S27 PF10037.9 EMC80623.1 - 1.9e-114 382.6 0.7 6.1e-114 380.9 0.7 1.6 1 1 0 1 1 1 1 Mitochondrial 28S ribosomal protein S27 PPR_2 PF13041.6 EMC80623.1 - 4.9e-07 29.8 0.6 0.0012 19.0 0.1 1.8 1 1 1 2 2 2 2 PPR repeat family PPR_1 PF12854.7 EMC80623.1 - 0.00011 21.8 0.1 0.00042 19.9 0.1 2.0 2 0 0 2 2 2 1 PPR repeat PPR PF01535.20 EMC80623.1 - 0.0031 17.6 0.0 0.012 15.8 0.0 2.1 1 0 0 1 1 1 1 PPR repeat PPR_3 PF13812.6 EMC80623.1 - 0.013 15.6 0.1 0.036 14.1 0.1 1.8 1 0 0 1 1 1 0 Pentatricopeptide repeat domain TPR_19 PF14559.6 EMC80623.1 - 0.12 12.9 0.0 0.45 11.1 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-C2H2 PF00096.26 EMC80624.1 - 7.6e-47 155.2 94.4 2.8e-05 24.3 1.6 11.6 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC80624.1 - 2.8e-36 122.3 77.9 1.7e-05 25.0 0.6 12.2 12 0 0 12 12 12 10 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC80624.1 - 4.7e-35 117.2 90.0 0.0015 19.2 1.1 11.7 11 0 0 11 11 11 11 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC80624.1 - 3.7e-11 42.7 75.5 0.0013 18.7 3.1 11.3 11 0 0 11 11 10 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC80624.1 - 4.4e-08 33.2 55.6 0.0073 16.6 2.7 10.7 10 1 1 11 11 11 4 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 EMC80624.1 - 4e-05 23.3 57.1 0.0079 15.9 0.1 10.7 11 0 0 11 11 11 3 zinc-finger C2H2-type zf-C2H2_3rep PF18868.1 EMC80624.1 - 0.00046 20.9 38.2 2.7 8.7 0.5 7.9 3 3 2 5 5 5 1 Zinc finger C2H2-type, 3 repeats zf-met PF12874.7 EMC80624.1 - 0.0015 18.9 59.5 0.037 14.4 1.6 10.0 10 0 0 10 10 10 4 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EMC80624.1 - 0.0017 18.6 65.3 1.6 9.1 0.2 9.8 1 1 7 9 9 9 2 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.6 EMC80624.1 - 0.0056 16.4 0.7 0.0056 16.4 0.7 10.1 10 0 0 10 10 10 3 C2H2-type zinc-finger domain zf_ZIC PF18366.1 EMC80624.1 - 0.0057 16.7 2.3 0.044 13.9 0.9 6.8 7 2 1 8 8 7 2 Zic proteins zinc finger domain HypA PF01155.19 EMC80624.1 - 0.022 14.7 26.4 0.082 12.9 1.2 4.9 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.10 EMC80624.1 - 0.036 14.2 39.9 0.65 10.2 2.6 7.8 6 3 2 8 8 8 0 Zinc ribbon domain Zn_ribbon_SprT PF17283.2 EMC80624.1 - 0.056 13.4 0.1 0.056 13.4 0.1 7.7 6 2 4 10 10 10 0 SprT-like zinc ribbon domain zf-C2HE PF16278.5 EMC80624.1 - 0.08 13.4 0.6 0.08 13.4 0.6 9.8 4 4 6 10 10 10 0 C2HE / C2H2 / C2HC zinc-binding finger zf-MIZ PF02891.20 EMC80624.1 - 0.1 12.4 0.1 0.1 12.4 0.1 3.6 4 1 1 5 5 4 0 MIZ/SP-RING zinc finger zf-Sec23_Sec24 PF04810.15 EMC80624.1 - 0.89 9.7 0.0 0.89 9.7 0.0 5.9 8 1 0 8 8 7 0 Sec23/Sec24 zinc finger FYVE PF01363.21 EMC80624.1 - 1.7 8.9 46.1 0.75 10.0 7.7 6.2 2 2 2 5 5 5 0 FYVE zinc finger zinc_ribbon_15 PF17032.5 EMC80624.1 - 2.6 8.8 32.4 14 6.5 0.5 5.8 1 1 2 5 5 5 0 zinc-ribbon family Sprouty PF05210.13 EMC80624.1 - 4.1 7.8 28.9 0.86 10.0 1.6 4.5 3 1 0 3 3 3 0 Sprouty protein (Spry) Ta0938 PF11494.8 EMC80624.1 - 7.6 6.9 7.6 32 4.9 0.0 4.1 2 2 2 4 4 4 0 Ta0938 HEAT_EZ PF13513.6 EMC80625.1 - 3e-35 120.2 0.5 1.6e-12 47.6 0.0 10.8 8 2 4 12 12 12 4 HEAT-like repeat HEAT PF02985.22 EMC80625.1 - 3.3e-31 104.7 7.6 0.0054 16.9 0.0 11.8 11 0 0 11 11 11 7 HEAT repeat HEAT_2 PF13646.6 EMC80625.1 - 1.7e-20 73.2 0.0 6.8e-06 26.4 0.0 7.0 6 2 3 9 9 8 5 HEAT repeats Arm PF00514.23 EMC80625.1 - 1e-17 63.5 5.6 0.0076 16.3 0.0 8.7 9 0 0 9 9 8 3 Armadillo/beta-catenin-like repeat IBN_N PF03810.19 EMC80625.1 - 2.2e-16 59.5 0.1 1.7e-15 56.7 0.0 2.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain Cnd1 PF12717.7 EMC80625.1 - 3.4e-16 59.7 0.2 0.00075 19.6 0.1 4.6 3 1 0 4 4 4 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EMC80625.1 - 1e-14 54.9 0.9 0.0012 19.4 0.1 6.9 6 2 3 9 9 8 5 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 EMC80625.1 - 1.7e-10 40.1 5.6 0.0022 16.6 0.7 5.3 2 2 1 4 4 4 4 Adaptin N terminal region UNC45-central PF11701.8 EMC80625.1 - 7.9e-05 22.7 2.3 0.029 14.4 0.1 4.0 4 0 0 4 4 4 1 Myosin-binding striated muscle assembly central Dopey_N PF04118.14 EMC80625.1 - 0.00056 19.1 0.3 0.0037 16.4 0.0 2.4 2 1 0 2 2 2 1 Dopey, N-terminal RTP1_C1 PF10363.9 EMC80625.1 - 0.00098 19.3 1.3 0.32 11.2 0.0 4.7 5 0 0 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 EMC80625.1 - 0.0011 18.5 0.7 1.3 8.5 0.0 4.5 3 2 1 4 4 4 1 CLASP N terminal MMS19_C PF12460.8 EMC80625.1 - 0.0065 15.6 2.2 1 8.4 0.1 4.1 3 2 0 3 3 3 1 RNAPII transcription regulator C-terminal Xpo1 PF08389.12 EMC80625.1 - 0.0083 16.2 3.4 5.4 7.1 0.0 5.2 5 1 0 6 6 5 1 Exportin 1-like protein DUF3437 PF11919.8 EMC80625.1 - 0.013 15.3 0.3 3.8 7.5 0.0 4.5 5 0 0 5 5 5 0 Domain of unknown function (DUF3437) DUF3689 PF12463.8 EMC80625.1 - 0.023 14.0 0.0 0.13 11.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3689) TAF6_C PF07571.13 EMC80625.1 - 0.046 14.0 0.0 1.3 9.4 0.0 3.2 3 0 0 3 3 3 0 TAF6 C-terminal HEAT repeat domain TAFH PF07531.14 EMC80625.1 - 0.11 12.6 1.2 13 6.0 0.0 3.8 4 1 1 5 5 3 0 NHR1 homology to TAF DALR_1 PF05746.15 EMC80625.1 - 0.2 11.8 0.4 1.6 8.9 0.0 2.4 2 0 0 2 2 2 0 DALR anticodon binding domain Tti2 PF10521.9 EMC80625.1 - 0.22 11.0 2.0 45 3.4 0.0 4.7 3 3 2 5 5 5 0 Tti2 family DUF2457 PF10446.9 EMC80625.1 - 3.2 6.8 7.7 4.7 6.2 7.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) muHD PF10291.9 EMC80626.1 - 4.2e-61 206.7 0.5 1e-60 205.4 0.5 1.6 1 1 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.23 EMC80626.1 - 7.5e-19 67.8 0.0 7.5e-19 67.8 0.0 3.0 2 1 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain DUF1664 PF07889.12 EMC80626.1 - 0.035 14.2 9.1 0.16 12.0 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) CheZ PF04344.13 EMC80626.1 - 0.16 11.9 5.1 0.37 10.7 5.1 1.7 1 0 0 1 1 1 0 Chemotaxis phosphatase, CheZ Prominin PF05478.11 EMC80626.1 - 0.18 9.7 12.0 0.34 8.8 11.6 1.5 1 1 0 1 1 1 0 Prominin CorA PF01544.18 EMC80626.1 - 0.33 10.2 3.1 1.7 7.9 0.9 2.1 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF948 PF06103.11 EMC80626.1 - 4.8 7.5 7.0 21 5.5 0.2 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) KMP11 PF03037.16 EMC80626.1 - 6.3 7.7 11.7 1 10.2 4.3 2.4 2 0 0 2 2 2 0 Kinetoplastid membrane protein 11 TMEM171 PF15471.6 EMC80627.1 - 2.4e-156 519.6 1.8 2.9e-156 519.4 1.8 1.0 1 0 0 1 1 1 1 Transmembrane protein family 171 SdpI PF13630.6 EMC80627.1 - 0.18 12.0 3.0 15 5.8 0.6 3.4 3 1 0 3 3 3 0 SdpI/YhfL protein family DUF2371 PF10177.9 EMC80627.1 - 0.31 11.2 0.6 3.9 7.7 0.4 2.4 1 1 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) TMEM174 PF15029.6 EMC80627.1 - 0.52 10.0 6.8 6 6.5 2.8 3.1 2 1 0 2 2 2 0 Transmembrane protein 174 EVC2_like PF12297.8 EMC80627.1 - 1.6 7.3 2.9 1.5 7.5 0.0 1.9 2 0 0 2 2 2 0 Ellis van Creveld protein 2 like protein Phage_holin_3_6 PF07332.11 EMC80627.1 - 3.1 7.9 10.2 13 5.9 5.5 2.4 1 1 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Tetraspanin PF00335.20 EMC80627.1 - 9 5.9 12.9 1.2 8.8 2.1 2.2 2 0 0 2 2 2 0 Tetraspanin family TMEM174 PF15029.6 EMC80628.1 - 5.3e-118 392.9 0.0 6e-118 392.7 0.0 1.0 1 0 0 1 1 1 1 Transmembrane protein 174 NAC PF01849.18 EMC80629.1 - 4.3e-26 90.6 0.2 7.9e-26 89.8 0.2 1.5 1 0 0 1 1 1 1 NAC domain Myco_19_kDa PF05481.12 EMC80629.1 - 0.065 13.5 0.5 0.12 12.6 0.5 1.5 1 1 0 1 1 1 0 Mycobacterium 19 kDa lipoprotein antigen LolA PF03548.15 EMC80629.1 - 0.067 12.9 0.5 0.087 12.5 0.5 1.2 1 0 0 1 1 1 0 Outer membrane lipoprotein carrier protein LolA Ank_2 PF12796.7 EMC80630.1 - 9.2e-23 80.6 0.0 1e-12 48.4 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC80630.1 - 2.4e-21 75.5 0.2 4.1e-07 30.2 0.1 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC80630.1 - 6.9e-20 69.0 0.0 5.1e-06 26.4 0.0 3.9 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 EMC80630.1 - 1.6e-19 69.4 0.0 6.5e-06 26.3 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 EMC80630.1 - 8.8e-19 67.6 0.2 4.6e-08 33.4 0.0 3.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) DUF1296 PF06972.11 EMC80630.1 - 0.32 11.2 1.3 2.9 8.1 0.0 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF1296) UTP15_C PF09384.10 EMC80631.1 - 3.7e-47 159.7 0.1 5.5e-47 159.1 0.1 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 EMC80631.1 - 8.2e-22 77.1 5.7 7.2e-06 26.7 0.1 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC80631.1 - 1.1e-10 41.6 0.0 0.00025 21.3 0.0 4.5 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EMC80631.1 - 0.00016 21.7 0.0 0.23 11.5 0.0 3.3 3 0 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region Salt_tol_Pase PF09506.10 EMC80631.1 - 0.12 11.1 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase) Ank_2 PF12796.7 EMC80632.1 - 0.00064 20.3 0.0 0.0015 19.1 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Kelch_1 PF01344.25 EMC80633.1 - 6.8e-50 166.4 7.6 1.5e-11 43.6 0.0 5.6 6 0 0 6 6 6 5 Kelch motif BACK PF07707.15 EMC80633.1 - 2e-30 104.9 1.4 6.8e-30 103.2 0.8 2.1 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 EMC80633.1 - 4.2e-29 101.0 0.2 8.2e-29 100.1 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.6 EMC80633.1 - 6.3e-24 83.4 5.6 2.3e-05 24.5 0.0 5.9 2 1 4 6 6 6 5 Kelch motif Kelch_2 PF07646.15 EMC80633.1 - 3.6e-21 74.2 2.6 0.00017 21.4 0.0 5.5 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.6 EMC80633.1 - 6.5e-20 70.9 0.8 3e-07 30.3 0.0 5.7 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_3 PF13415.6 EMC80633.1 - 1.4e-19 69.8 4.3 5.1e-05 23.4 0.0 6.1 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC80633.1 - 1.5e-13 50.4 6.5 8.5e-07 28.8 0.0 5.3 6 0 0 6 6 6 3 Kelch motif DUF3342 PF11822.8 EMC80633.1 - 0.00024 21.2 0.0 0.0017 18.5 0.0 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3342) PFU PF09070.11 EMC80633.1 - 0.027 14.7 0.0 0.073 13.3 0.0 1.8 1 0 0 1 1 1 0 PFU (PLAA family ubiquitin binding) Glyco_hydro_20 PF00728.22 EMC80634.1 - 7.2e-82 275.6 0.0 9.8e-82 275.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EMC80634.1 - 3.1e-10 40.9 0.0 5e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EMC80634.1 - 0.0087 16.8 0.0 0.014 16.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 GTP_EFTU PF00009.27 EMC80635.1 - 1.5e-66 223.7 0.0 2.4e-66 223.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 EMC80635.1 - 4.9e-29 100.2 0.0 2e-28 98.2 0.0 2.2 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EMC80635.1 - 4.1e-23 81.2 0.0 1e-22 79.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 EMC80635.1 - 2.8e-12 46.5 0.3 6.7e-12 45.2 0.0 1.8 2 0 0 2 2 2 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.25 EMC80635.1 - 2.7e-08 34.1 0.0 6e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EMC80635.1 - 4.7e-08 32.9 0.0 2.1e-07 30.9 0.0 1.9 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 EMC80635.1 - 0.00012 22.1 0.0 0.00027 21.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AvrPtoB_bdg PF16847.5 EMC80635.1 - 0.0016 18.9 0.1 0.068 13.7 0.0 3.0 3 0 0 3 3 3 1 Avirulence AvrPtoB, BAK1-binding domain FeoB_N PF02421.18 EMC80635.1 - 0.021 14.3 0.0 0.13 11.8 0.0 2.3 2 1 0 2 2 2 0 Ferrous iron transport protein B AIG1 PF04548.16 EMC80635.1 - 0.053 12.8 0.0 0.14 11.4 0.0 1.7 1 0 0 1 1 1 0 AIG1 family Ribosomal_S8e PF01201.22 EMC80636.1 - 2.3e-50 170.3 10.3 4.7e-50 169.3 10.3 1.5 1 1 0 1 1 1 1 Ribosomal protein S8e HU-CCDC81_euk_2 PF18289.1 EMC80638.1 - 8.7e-18 64.3 0.0 1.3e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 2 BAH PF01426.18 EMC80639.1 - 6.1e-16 58.4 0.0 9.9e-16 57.7 0.0 1.3 1 0 0 1 1 1 1 BAH domain DUF2090 PF09863.9 EMC80639.1 - 0.003 16.6 0.0 0.0049 15.9 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2090) Fascin PF06268.13 EMC80641.1 - 1.4e-14 54.2 0.1 1.7e-14 53.9 0.1 1.2 1 0 0 1 1 1 1 Fascin domain FANCAA PF15146.6 EMC80642.1 - 1.3e-147 492.5 1.1 2.1e-147 491.8 1.1 1.3 1 1 0 1 1 1 1 Fanconi anemia-associated NPL4 PF05021.15 EMC80643.1 - 2.3e-92 309.7 0.0 3.9e-92 308.9 0.0 1.3 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 EMC80643.1 - 1.7e-62 209.8 0.2 3e-62 209.1 0.2 1.4 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.8 EMC80643.1 - 6.5e-31 106.7 0.1 1.2e-30 105.8 0.1 1.5 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 PDE6_gamma PF04868.12 EMC80644.1 - 9.1e-49 163.6 0.6 1e-48 163.5 0.6 1.0 1 0 0 1 1 1 1 Retinal cGMP phosphodiesterase, gamma subunit 7tm_3 PF00003.22 EMC80645.1 - 6e-33 114.5 14.9 8.2e-33 114.1 14.9 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR PalH PF08733.10 EMC80645.1 - 1 8.3 4.7 9.2 5.2 0.0 2.3 1 1 1 2 2 2 0 PalH/RIM21 DUF3341 PF11821.8 EMC80645.1 - 1.4 8.6 4.8 0.52 9.9 0.5 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3341) 7tm_1 PF00001.21 EMC80646.1 - 2.7e-24 85.9 20.9 3.2e-24 85.7 20.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC80646.1 - 2.1e-07 30.9 9.0 2.1e-07 30.9 9.0 2.1 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.9 EMC80646.1 - 2.6e-06 26.9 2.5 2.6e-06 26.9 2.5 2.3 1 1 1 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srw DUF1472 PF07339.12 EMC80646.1 - 0.014 15.9 1.9 3.6 8.2 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1472) 7tm_4 PF13853.6 EMC80646.1 - 0.035 13.9 9.4 0.17 11.6 9.4 2.1 1 1 0 1 1 1 0 Olfactory receptor DUF2116 PF09889.9 EMC80646.1 - 0.092 12.7 6.5 0.49 10.4 0.1 3.3 3 0 0 3 3 3 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) 7TM_GPCR_Srbc PF10316.9 EMC80646.1 - 1.7 8.0 19.1 0.037 13.5 7.5 2.4 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srbc Polysacc_lyase PF14099.6 EMC80647.1 - 0.015 15.2 0.0 0.018 14.9 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide lyase Ribosomal_L38e PF01781.18 EMC80648.1 - 9.9e-36 121.7 4.5 1.1e-35 121.6 4.5 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family WRW PF10206.9 EMC80649.1 - 1.2e-11 44.9 0.0 1.4e-11 44.6 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial F1F0-ATP synthase, subunit f F1F0-ATPsyn_F PF10791.9 EMC80649.1 - 0.096 13.2 0.0 0.12 12.9 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial F1-F0 ATP synthase subunit F of fungi FAM104 PF15434.6 EMC80651.1 - 1.4e-46 157.5 6.8 2e-46 157.0 6.8 1.2 1 0 0 1 1 1 1 Family 104 SR-25 PF10500.9 EMC80651.1 - 0.075 12.6 13.8 0.1 12.2 13.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CDK2AP PF09806.9 EMC80651.1 - 0.22 11.6 2.1 0.25 11.4 2.1 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Caskin1-CID PF16600.5 EMC80652.1 - 0.05 14.2 1.2 0.089 13.4 1.2 1.4 1 0 0 1 1 1 0 Caskin1 CASK-interaction domain 7tm_1 PF00001.21 EMC80653.1 - 5.8e-65 219.2 19.8 7.6e-65 218.8 19.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC80653.1 - 2.7e-16 59.8 21.3 3.6e-16 59.3 21.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC80653.1 - 2.5e-12 47.0 18.3 2.5e-12 47.0 18.3 2.3 1 1 2 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 EMC80653.1 - 2.3e-11 43.6 8.3 2.3e-11 43.6 8.3 2.1 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv Zip PF02535.22 EMC80654.1 - 5.3e-24 85.0 8.7 1.7e-23 83.4 8.7 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter Sox_N PF12444.8 EMC80655.1 - 2.2e-26 92.8 0.5 2.2e-26 92.8 0.5 2.3 2 1 0 2 2 2 1 Sox developmental protein N terminal HMG_box PF00505.19 EMC80655.1 - 4.8e-26 91.0 2.6 5.3e-26 90.8 1.3 1.7 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC80655.1 - 3.5e-11 43.5 1.1 6.4e-11 42.7 1.1 1.5 1 0 0 1 1 1 1 HMG-box domain IRK_C PF17655.1 EMC80656.1 - 2.9e-77 258.2 0.0 4.3e-77 257.6 0.0 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 EMC80656.1 - 1.8e-64 215.8 6.2 2.6e-64 215.3 6.2 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain IRK_N PF08466.10 EMC80656.1 - 1.7e-26 92.0 1.3 3.5e-26 91.1 1.3 1.6 1 0 0 1 1 1 1 Inward rectifier potassium channel N-terminal Ion_trans_2 PF07885.16 EMC80656.1 - 0.0011 18.8 6.4 0.0027 17.6 6.4 1.7 1 1 0 1 1 1 1 Ion channel Ion_trans PF00520.31 EMC80656.1 - 0.0033 16.7 5.4 0.0047 16.2 5.4 1.2 1 0 0 1 1 1 1 Ion transport protein IRK_C PF17655.1 EMC80657.1 - 2.4e-62 209.6 0.0 3.7e-62 209.0 0.0 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 EMC80657.1 - 2e-57 193.0 6.6 3e-57 192.4 6.6 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 EMC80657.1 - 0.00024 21.0 2.6 0.00052 19.9 2.6 1.7 1 0 0 1 1 1 1 Ion channel Pkinase PF00069.25 EMC80659.1 - 3.8e-07 29.8 0.0 4.4e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC80659.1 - 0.00056 19.3 0.0 0.00066 19.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase ABC_tran PF00005.27 EMC80660.1 - 1.5e-54 184.2 0.0 1.2e-28 100.3 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 EMC80660.1 - 9.5e-31 107.2 44.2 3.2e-23 82.4 11.7 2.7 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 EMC80660.1 - 9.9e-19 68.3 5.3 3.8e-08 33.5 0.0 4.4 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EMC80660.1 - 6e-10 39.3 2.2 0.00046 20.1 0.1 2.6 3 0 0 3 3 2 2 RsgA GTPase AAA_29 PF13555.6 EMC80660.1 - 3.6e-05 23.4 3.9 0.034 13.9 0.4 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.19 EMC80660.1 - 0.00012 21.6 0.5 0.23 10.9 0.1 3.4 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EMC80660.1 - 0.00017 22.2 4.3 0.2 12.1 0.4 2.6 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EMC80660.1 - 0.00053 20.4 3.6 0.51 10.7 0.1 3.8 3 1 0 3 3 3 1 AAA ATPase domain DUF4162 PF13732.6 EMC80660.1 - 0.00094 19.9 0.0 0.042 14.6 0.0 2.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4162) MMR_HSR1 PF01926.23 EMC80660.1 - 0.0071 16.4 1.8 3.6 7.7 0.2 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.6 EMC80660.1 - 0.0097 16.2 0.3 1.1 9.5 0.0 2.8 3 0 0 3 3 2 1 AAA domain Rad17 PF03215.15 EMC80660.1 - 0.011 15.7 0.2 0.86 9.5 0.1 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_15 PF13175.6 EMC80660.1 - 0.028 14.1 2.0 0.78 9.4 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_30 PF13604.6 EMC80660.1 - 0.036 13.8 1.9 6.2 6.5 0.0 2.7 2 1 0 2 2 2 0 AAA domain DLIC PF05783.11 EMC80660.1 - 0.047 12.5 0.0 0.091 11.6 0.0 1.3 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_24 PF13479.6 EMC80660.1 - 0.062 13.0 0.5 9.6 5.9 0.0 2.6 3 0 0 3 3 2 0 AAA domain cobW PF02492.19 EMC80660.1 - 0.16 11.5 1.2 1.4 8.4 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EMC80660.1 - 0.97 9.3 4.2 5.1 7.0 0.3 3.7 4 0 0 4 4 4 0 NACHT domain G-alpha PF00503.20 EMC80660.1 - 1.5 7.9 4.2 3.7 6.6 0.0 2.8 3 0 0 3 3 3 0 G-protein alpha subunit DUF1129 PF06570.11 EMC80660.1 - 6.5 6.2 9.6 3.9 6.9 5.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) cNMP_binding PF00027.29 EMC80661.1 - 3e-41 139.4 0.0 3.4e-20 71.9 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.17 EMC80661.1 - 2.8e-14 52.5 0.1 5.8e-14 51.5 0.1 1.6 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Cupin_2 PF07883.11 EMC80661.1 - 0.016 14.9 2.1 1.4 8.6 0.1 2.3 2 0 0 2 2 2 0 Cupin domain Cupin_3 PF05899.12 EMC80661.1 - 1.1 9.0 2.8 27 4.6 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF861) WD40 PF00400.32 EMC80662.1 - 0.00085 20.1 0.0 16 6.5 0.0 3.7 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC80662.1 - 0.0042 17.4 0.0 0.85 10.0 0.0 3.7 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain BCAS3 PF12490.8 EMC80662.1 - 0.029 13.9 0.0 0.044 13.3 0.0 1.2 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 3 Sulfatase_C PF14707.6 EMC80663.1 - 2.5e-23 83.1 0.0 2.9e-23 82.9 0.0 1.1 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase MFS_1 PF07690.16 EMC80665.1 - 2.3e-33 115.6 18.9 2.8e-31 108.7 14.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMC80665.1 - 0.00045 19.2 28.4 0.00047 19.1 7.0 3.0 2 2 1 3 3 3 2 Sugar (and other) transporter Pex14_N PF04695.13 EMC80665.1 - 0.085 13.5 0.5 0.23 12.1 0.0 1.9 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RGS_DHEX PF18148.1 EMC80666.1 - 1.3e-44 150.4 2.9 2.8e-44 149.3 2.9 1.6 1 0 0 1 1 1 1 Regulator of G-protein signalling DHEX domain RGS PF00615.19 EMC80666.1 - 1e-31 109.7 0.0 1.8e-31 108.8 0.0 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain DEP PF00610.21 EMC80666.1 - 5.1e-13 48.9 0.0 1.4e-12 47.5 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) G-gamma PF00631.22 EMC80666.1 - 1.1e-08 35.0 0.0 4.9e-08 32.8 0.0 2.0 2 0 0 2 2 2 1 GGL domain DUF4485 PF14846.6 EMC80667.1 - 5.1e-28 97.0 0.0 5.1e-28 97.0 0.0 5.0 4 2 1 5 5 5 1 Domain of unknown function (DUF4485) DUF148 PF02520.17 EMC80667.1 - 0.00011 22.3 11.5 0.00011 22.3 11.5 8.2 1 1 7 8 8 8 1 Domain of unknown function DUF148 Tup_N PF08581.10 EMC80667.1 - 0.0048 17.2 8.2 0.0048 17.2 8.2 10.8 5 3 6 11 11 11 2 Tup N-terminal DUF424 PF04242.13 EMC80667.1 - 0.78 10.0 3.5 1.9 8.8 0.3 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF424) Sushi PF00084.20 EMC80668.1 - 1.9e-42 143.6 23.6 5.6e-12 46.1 1.0 5.1 5 0 0 5 5 5 4 Sushi repeat (SCR repeat) Sushi_2 PF09014.10 EMC80668.1 - 6.1e-29 99.8 1.2 6.1e-29 99.8 1.2 2.4 4 0 0 4 4 4 1 Beta-2-glycoprotein-1 fifth domain HRM PF02793.22 EMC80668.1 - 0.0018 18.5 14.2 3.5 8.0 1.4 4.5 3 1 1 4 4 4 3 Hormone receptor domain Meleagrin PF08189.11 EMC80668.1 - 7.7 6.3 13.5 2.8 7.7 0.9 4.3 5 0 0 5 5 5 0 Meleagrin/Cygnin family FANCI_S4 PF14678.6 EMC80669.1 - 0.066 12.3 9.2 0.86 8.7 2.5 2.4 2 1 0 2 2 2 0 FANCI solenoid 4 HemS PF05171.12 EMC80670.1 - 1.4 8.9 6.1 33 4.4 0.1 3.9 1 1 3 4 4 4 0 Haemin-degrading HemS.ChuX domain TFIID-31kDa PF02291.15 EMC80671.1 - 6.5e-52 174.7 0.0 9.9e-52 174.2 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CENP-S PF15630.6 EMC80671.1 - 7.8e-07 29.4 0.1 1.4e-06 28.6 0.1 1.4 1 0 0 1 1 1 1 CENP-S protein Bromo_TP PF07524.13 EMC80671.1 - 1e-06 28.7 0.0 1.8e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated Histone PF00125.24 EMC80671.1 - 0.00043 20.6 0.2 0.00078 19.8 0.2 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EMC80671.1 - 0.0028 17.8 0.1 0.0051 16.9 0.1 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID_30kDa PF03540.13 EMC80671.1 - 0.023 14.6 0.1 3.6 7.6 0.0 2.6 2 0 0 2 2 2 0 Transcription initiation factor TFIID 23-30kDa subunit TIP49_C PF17856.1 EMC80671.1 - 0.15 12.2 0.1 0.32 11.2 0.1 1.5 1 0 0 1 1 1 0 TIP49 AAA-lid domain YtxC PF08812.11 EMC80671.1 - 0.16 11.5 0.1 0.22 11.1 0.1 1.2 1 0 0 1 1 1 0 YtxC-like family 7tm_1 PF00001.21 EMC80672.1 - 4.9e-45 153.9 24.3 6e-45 153.6 24.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC80672.1 - 9.5e-13 48.4 24.7 9.5e-13 48.4 24.7 1.5 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 EMC80672.1 - 8.8e-06 25.3 20.8 1.2e-05 24.8 20.8 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv TAS2R PF05296.13 EMC80672.1 - 1.3e-05 24.5 20.6 1.8e-05 24.0 20.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_4 PF13853.6 EMC80672.1 - 0.0007 19.4 17.6 0.0019 18.0 17.5 1.6 1 1 0 1 1 1 1 Olfactory receptor COX7C PF02935.16 EMC80672.1 - 8.9 6.7 7.3 17 5.8 0.4 3.4 3 0 0 3 3 3 0 Cytochrome c oxidase subunit VIIc 7tm_1 PF00001.21 EMC80673.1 - 7.5e-10 38.6 13.4 9e-10 38.3 13.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 EMC80674.1 - 1.7e-52 178.4 24.0 1.7e-52 178.4 24.0 1.3 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC80674.1 - 5.7e-08 32.5 26.2 7.9e-08 32.0 26.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Serpentine_r_xa PF03383.15 EMC80674.1 - 0.093 12.7 16.9 0.026 14.5 2.2 2.7 1 1 1 2 2 2 0 Caenorhabditis serpentine receptor-like protein, class xa 7TM_GPCR_Srx PF10328.9 EMC80674.1 - 0.18 11.4 33.8 0.48 10.0 32.1 2.3 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.21 EMC80675.1 - 3e-27 95.6 13.9 3.8e-27 95.3 13.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 EMC80676.1 - 0.0024 17.2 9.8 0.0029 17.0 9.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 EMC80676.1 - 0.12 11.7 8.4 0.14 11.4 8.4 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_1 PF00001.21 EMC80677.1 - 3.1e-40 138.2 20.7 4.2e-40 137.8 20.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 EMC80678.1 - 2.7e-38 131.8 20.1 3.4e-38 131.5 20.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 EMC80678.1 - 0.00019 20.8 18.8 0.00026 20.4 1.5 2.6 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srw BRICHOS PF04089.14 EMC80679.1 - 4.4e-18 65.3 0.0 1e-17 64.1 0.0 1.6 2 0 0 2 2 2 1 BRICHOS domain Snf7 PF03357.21 EMC80680.1 - 6e-16 58.5 16.5 6e-16 58.5 16.5 1.4 2 0 0 2 2 2 1 Snf7 Ist1 PF03398.14 EMC80680.1 - 5.5e-05 23.2 7.3 7.9e-05 22.6 7.3 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway FlxA PF14282.6 EMC80680.1 - 0.05 13.6 0.6 0.05 13.6 0.6 2.8 2 1 1 3 3 3 0 FlxA-like protein DUF948 PF06103.11 EMC80680.1 - 0.051 13.8 6.5 0.051 13.8 4.4 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DMSP_lyase PF16867.5 EMC80680.1 - 0.067 12.8 0.2 0.12 12.0 0.2 1.4 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase Mu-like_Pro PF10123.9 EMC80680.1 - 0.15 11.6 8.9 0.2 11.1 8.9 1.2 1 0 0 1 1 1 0 Mu-like prophage I protein Mt_ATP-synt_D PF05873.12 EMC80680.1 - 0.26 11.1 8.7 0.81 9.5 0.3 2.6 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) NTP_transf_7 PF07984.12 EMC80681.1 - 5.2e-158 525.4 3.7 5.9e-158 525.2 3.7 1.0 1 0 0 1 1 1 1 Nucleotidyltransferase NTF2 PF02136.20 EMC80683.1 - 3.1e-30 105.2 0.4 3.6e-30 105.0 0.4 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain SnoaL_2 PF12680.7 EMC80683.1 - 0.023 15.3 0.0 0.027 15.1 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like domain ODR4-like PF14778.6 EMC80683.1 - 0.1 11.5 0.0 0.12 11.3 0.0 1.1 1 0 0 1 1 1 0 Olfactory receptor 4-like OST3_OST6 PF04756.13 EMC80684.1 - 8.7e-107 356.8 0.0 9.8e-107 356.6 0.0 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin PF00085.20 EMC80684.1 - 3.8e-05 23.6 0.0 5.8e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Yip1 PF04893.17 EMC80684.1 - 0.67 9.7 5.5 2.1 8.0 5.5 1.8 1 1 0 1 1 1 0 Yip1 domain DUF4131 PF13567.6 EMC80684.1 - 0.89 9.2 4.7 0.38 10.4 0.4 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4131) COX7B PF05392.11 EMC80685.1 - 2.9e-31 106.9 0.1 3.2e-31 106.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome C oxidase chain VIIB HMA PF00403.26 EMC80686.1 - 1.1e-88 291.7 16.0 1.8e-14 53.9 0.0 7.6 7 0 0 7 7 7 7 Heavy-metal-associated domain Hydrolase PF00702.26 EMC80686.1 - 2.6e-61 207.6 0.5 5.5e-61 206.5 0.5 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EMC80686.1 - 1.3e-37 129.0 1.4 1.3e-37 129.0 1.4 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EMC80686.1 - 6.9e-06 26.0 2.4 0.00032 20.5 1.5 2.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase RRM_3 PF08777.11 EMC80686.1 - 0.00011 22.2 0.0 15 5.7 0.0 5.3 6 0 0 6 6 6 0 RNA binding motif CT_C_D PF02682.16 EMC80686.1 - 0.0053 16.5 0.2 1.4 8.6 0.0 3.3 4 0 0 4 4 4 1 Carboxyltransferase domain, subdomain C and D Hydrolase_6 PF13344.6 EMC80686.1 - 0.0081 16.3 0.3 0.053 13.6 0.1 2.7 3 0 0 3 3 1 1 Haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EMC80686.1 - 0.029 14.4 0.1 0.075 13.1 0.1 1.7 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Spore_YhcN_YlaJ PF09580.10 EMC80686.1 - 0.043 13.9 3.2 3.5 7.7 0.1 3.2 3 0 0 3 3 3 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) RRM_occluded PF16842.5 EMC80686.1 - 0.056 13.3 0.2 0.34 10.8 0.1 2.4 2 0 0 2 2 2 0 Occluded RNA-recognition motif UPF0270 PF06794.12 EMC80686.1 - 0.11 12.6 0.3 31 4.7 0.0 3.9 4 0 0 4 4 3 0 Uncharacterised protein family (UPF0270) Germane PF10646.9 EMC80686.1 - 1.8 9.4 4.4 10 7.0 0.1 4.2 4 1 0 4 4 4 0 Sporulation and spore germination DUF2997 PF11211.8 EMC80686.1 - 4 7.3 18.2 6.9 6.5 0.6 4.9 5 0 0 5 5 5 0 Protein of unknown function (DUF2997) Fer2_BFD PF04324.15 EMC80686.1 - 9.6 6.7 18.9 1e+02 3.4 0.0 6.9 7 0 0 7 7 7 0 BFD-like [2Fe-2S] binding domain PGK PF00162.19 EMC80687.1 - 6.5e-144 479.5 1.3 7.3e-144 479.4 1.3 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase Ion_trans PF00520.31 EMC80688.1 - 4.1e-33 114.6 13.1 6.1e-33 114.1 13.1 1.2 1 0 0 1 1 1 1 Ion transport protein TRP_2 PF08344.11 EMC80688.1 - 6.6e-29 99.9 0.3 1.4e-28 98.9 0.3 1.6 1 0 0 1 1 1 1 Transient receptor ion channel II Ank_2 PF12796.7 EMC80688.1 - 7.3e-11 42.5 1.1 2.8e-06 27.8 0.4 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC80688.1 - 1.3e-07 32.0 0.0 0.016 15.7 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC80688.1 - 1.9e-06 27.7 3.5 0.17 12.5 0.0 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 EMC80688.1 - 4.4e-05 23.7 0.3 0.074 13.5 0.0 3.3 2 1 0 2 2 2 2 Ankyrin repeat PKD_channel PF08016.12 EMC80688.1 - 6.7e-05 21.8 14.2 0.008 14.9 2.7 2.8 2 1 0 2 2 2 2 Polycystin cation channel Ank_5 PF13857.6 EMC80688.1 - 0.00018 21.7 0.4 0.79 10.1 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Gp-FAR-1 PF05823.12 EMC80688.1 - 0.016 15.6 8.7 0.76 10.1 1.1 3.2 3 0 0 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF1340 PF07067.11 EMC80688.1 - 0.1 12.0 0.2 0.2 11.0 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1340) DCX PF03607.17 EMC80690.1 - 2.6e-43 145.9 0.1 4.3e-22 78.0 0.0 2.4 2 0 0 2 2 2 2 Doublecortin MGC-24 PF05283.11 EMC80690.1 - 0.11 12.9 4.3 0.15 12.5 0.9 2.2 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF2457 PF10446.9 EMC80690.1 - 1.1 8.3 9.8 0.07 12.3 4.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) Peptidase_C2 PF00648.21 EMC80691.1 - 1e-118 395.7 0.6 1.6e-118 395.1 0.6 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 EMC80691.1 - 6.4e-34 117.2 0.0 1.1e-33 116.4 0.0 1.4 1 0 0 1 1 1 1 Calpain large subunit, domain III C2 PF00168.30 EMC80691.1 - 1.1e-12 48.2 0.3 6.4e-12 45.7 0.0 2.1 2 0 0 2 2 2 1 C2 domain Pkinase PF00069.25 EMC80693.1 - 1e-72 244.7 0.0 1.5e-72 244.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC80693.1 - 1.6e-45 155.4 0.0 2.5e-45 154.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EMC80693.1 - 1.1e-23 83.3 0.0 3.3e-23 81.8 0.0 1.8 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 EMC80693.1 - 1.3e-07 31.3 0.1 0.00034 20.0 0.0 2.7 2 1 1 3 3 3 2 Kinase-like Pkinase_fungal PF17667.1 EMC80693.1 - 1.5e-06 27.3 0.7 4.5e-06 25.7 0.7 1.9 1 1 0 1 1 1 1 Fungal protein kinase Spt5_N PF11942.8 EMC80693.1 - 0.00065 20.6 2.4 0.0015 19.4 2.4 1.6 1 0 0 1 1 1 1 Spt5 transcription elongation factor, acidic N-terminal APH PF01636.23 EMC80693.1 - 0.0057 16.6 0.1 0.068 13.1 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family DSHCT PF08148.12 EMC80693.1 - 0.014 15.0 0.0 0.028 14.1 0.0 1.5 1 0 0 1 1 1 0 DSHCT (NUC185) domain Kdo PF06293.14 EMC80693.1 - 0.058 12.7 0.0 0.13 11.6 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family SOG2 PF10428.9 EMC80693.1 - 0.56 9.4 8.2 0.89 8.7 8.2 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein VWC PF00093.18 EMC80694.1 - 3.9e-27 94.3 59.4 1.2e-09 38.4 10.2 3.8 4 0 0 4 4 4 3 von Willebrand factor type C domain Amnionless PF14828.6 EMC80694.1 - 0.0011 17.9 7.0 0.0011 17.9 7.0 3.2 1 1 2 3 3 3 3 Amnionless DUF1496 PF07383.12 EMC80694.1 - 0.01 15.4 2.4 2.2 7.9 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1496) AMMECR1 PF01871.17 EMC80695.1 - 1.7e-47 161.1 0.0 2e-47 160.9 0.0 1.0 1 0 0 1 1 1 1 AMMECR1 AMP-binding PF00501.28 EMC80696.1 - 3e-108 362.1 0.0 4e-108 361.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMC80696.1 - 8.9e-07 29.8 0.0 4.1e-05 24.5 0.0 2.6 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain CelTOS PF18659.1 EMC80696.1 - 0.091 13.2 0.0 0.26 11.7 0.0 1.7 1 0 0 1 1 1 0 Cell-traversal protein for ookinetes and sporozoites Pkinase_Tyr PF07714.17 EMC80697.1 - 1.3e-92 309.7 0.0 1.8e-92 309.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC80697.1 - 7e-47 160.0 0.0 1.1e-46 159.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 EMC80697.1 - 1.1e-21 76.7 0.1 2.8e-21 75.4 0.1 1.7 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 EMC80697.1 - 5.2e-15 54.8 0.1 1.2e-14 53.7 0.1 1.7 1 0 0 1 1 1 1 SH3 domain PH PF00169.29 EMC80697.1 - 8e-14 52.0 0.4 8.8e-13 48.7 0.1 2.6 2 1 0 2 2 2 1 PH domain BTK PF00779.19 EMC80697.1 - 3.7e-13 49.0 1.9 8.5e-13 47.9 1.9 1.7 1 0 0 1 1 1 1 BTK motif SH3_9 PF14604.6 EMC80697.1 - 3.1e-09 36.5 0.1 7.4e-09 35.3 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC80697.1 - 5.1e-06 26.1 0.0 1.4e-05 24.6 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 EMC80697.1 - 0.00032 20.9 0.1 0.00076 19.7 0.1 1.7 1 0 0 1 1 1 1 Bacterial SH3 domain Kinase-like PF14531.6 EMC80697.1 - 0.0012 18.2 0.0 0.0019 17.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like SH3_10 PF17902.1 EMC80697.1 - 0.0079 16.2 0.0 0.018 15.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain Pkinase_fungal PF17667.1 EMC80697.1 - 0.021 13.6 0.0 0.033 13.0 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 EMC80697.1 - 0.022 13.7 0.0 0.035 13.0 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 EMC80697.1 - 0.063 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMC80697.1 - 0.073 13.0 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ribosomal_L44 PF00935.19 EMC80698.1 - 1e-38 131.6 9.2 1e-38 131.6 9.2 1.7 1 1 1 2 2 2 1 Ribosomal protein L44 Melibiase_2 PF16499.5 EMC80699.1 - 4.8e-135 449.2 0.7 5.8e-135 449.0 0.7 1.1 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase_2_C PF17450.2 EMC80699.1 - 1.2e-28 99.1 0.0 2.2e-28 98.3 0.0 1.4 1 0 0 1 1 1 1 Alpha galactosidase A C-terminal beta sandwich domain Melibiase PF02065.18 EMC80699.1 - 8.6e-06 24.9 0.0 1.8e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Melibiase Melibiase_C PF17801.1 EMC80699.1 - 1.3e-05 25.2 0.0 5.4e-05 23.2 0.0 2.1 2 1 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain DUF3215 PF11503.8 EMC80699.1 - 0.1 12.5 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3215) Neur_chan_LBD PF02931.23 EMC80700.1 - 3.9e-52 176.8 0.1 4.9e-52 176.5 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC80700.1 - 2.5e-39 135.8 0.4 4.3e-34 118.6 0.1 2.1 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Myelin_PLP PF01275.19 EMC80701.1 - 1.5e-104 349.1 13.3 1.8e-104 348.8 13.3 1.1 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) Comm PF15957.5 EMC80701.1 - 0.099 13.0 0.2 0.27 11.6 0.2 1.6 1 0 0 1 1 1 0 Commissureless DUF2207 PF09972.9 EMC80701.1 - 2.1 7.0 4.0 0.78 8.4 0.1 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Ras PF00071.22 EMC80702.1 - 1.3e-56 190.6 0.0 1.8e-56 190.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC80702.1 - 1.4e-30 106.0 0.0 2.2e-30 105.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC80702.1 - 4.9e-10 39.1 0.0 5.4e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC80702.1 - 2.2e-06 27.8 0.0 3.5e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMC80702.1 - 6.2e-06 25.7 0.0 9.7e-06 25.1 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EMC80702.1 - 2.3e-05 24.4 0.1 0.012 15.5 0.1 2.5 2 1 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EMC80702.1 - 0.00015 21.4 0.0 0.00023 20.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 EMC80702.1 - 0.0067 16.0 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 EMC80702.1 - 0.032 14.6 0.0 0.048 14.1 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 EMC80702.1 - 0.052 12.7 1.7 0.74 8.9 0.1 2.5 1 1 1 2 2 2 0 G-protein alpha subunit FeoB_N PF02421.18 EMC80702.1 - 0.16 11.5 0.0 0.26 10.8 0.0 1.6 1 1 0 1 1 1 0 Ferrous iron transport protein B Thymosin PF01290.20 EMC80703.1 - 1.5e-19 69.4 13.6 1.9e-19 69.1 13.6 1.0 1 0 0 1 1 1 1 Thymosin beta-4 family DUF4522 PF15022.6 EMC80703.1 - 0.019 15.2 0.3 0.02 15.1 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4522) FERM_N PF09379.10 EMC80704.1 - 4.6e-05 23.3 0.0 6.2e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 FERM N-terminal domain FERM_f0 PF16511.5 EMC80704.1 - 0.018 15.4 0.0 0.023 15.0 0.0 1.2 1 0 0 1 1 1 0 N-terminal or F0 domain of Talin-head FERM PIH1_CS PF18201.1 EMC80705.1 - 2.8e-10 40.5 0.1 4.1e-10 39.9 0.1 1.2 1 0 0 1 1 1 1 PIH1 CS-like domain ERGIC_N PF13850.6 EMC80705.1 - 0.067 13.5 0.2 0.13 12.6 0.2 1.5 1 0 0 1 1 1 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) DUF2677 PF10838.8 EMC80705.1 - 0.12 12.3 0.1 0.16 11.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2677) RhoGAP PF00620.27 EMC80706.1 - 1.3e-51 174.5 1.1 1.4e-32 112.6 0.4 2.4 2 0 0 2 2 2 2 RhoGAP domain AAA_19 PF13245.6 EMC80706.1 - 6.1e-06 26.6 0.3 0.21 11.9 0.1 2.6 3 0 0 3 3 3 2 AAA domain RMMBL PF07521.12 EMC80706.1 - 1.9e-05 24.5 0.1 0.35 10.8 0.0 2.5 2 0 0 2 2 2 2 Zn-dependent metallo-hydrolase RNA specificity domain UvrD-helicase PF00580.21 EMC80706.1 - 0.00035 20.2 0.1 0.81 9.1 0.0 2.3 2 1 0 2 2 2 2 UvrD/REP helicase N-terminal domain RsbRD_N PF14361.6 EMC80706.1 - 0.12 13.1 2.8 28 5.5 0.1 3.6 4 0 0 4 4 4 0 RsbT co-antagonist protein rsbRD N-terminal domain Spt20 PF12090.8 EMC80707.1 - 6.7e-35 120.8 10.5 8.4e-20 71.4 0.0 2.9 2 1 1 3 3 3 2 Spt20 family RNase_PH PF01138.21 EMC80708.1 - 2e-24 86.6 0.2 3.7e-24 85.7 0.2 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EMC80708.1 - 4.2e-12 45.9 0.0 7.4e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Glycos_transf_2 PF00535.26 EMC80709.1 - 1.9e-24 86.4 0.0 2.4e-24 86.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EMC80709.1 - 6.1e-08 32.8 0.0 9.2e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EMC80709.1 - 0.015 14.8 0.0 0.018 14.5 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase like family 2 MH2 PF03166.14 EMC80710.1 - 1.4e-74 250.3 1.6 1.9e-74 249.9 1.6 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.16 EMC80710.1 - 1.5e-42 144.0 1.2 3.6e-42 142.8 1.2 1.7 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.9 EMC80710.1 - 0.0013 18.5 0.0 0.0021 17.9 0.0 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 DUF4223 PF13978.6 EMC80710.1 - 0.02 14.8 0.5 0.044 13.8 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4223) RFXA_RFXANK_bdg PF15289.6 EMC80711.1 - 3.8e-30 104.8 6.5 4.2e-30 104.6 6.5 1.0 1 0 0 1 1 1 1 Regulatory factor X-associated C-terminal binding domain DnaI_N PF07319.11 EMC80711.1 - 0.033 14.8 0.1 0.04 14.6 0.1 1.1 1 0 0 1 1 1 0 Primosomal protein DnaI N-terminus UPF0302 PF08864.10 EMC80711.1 - 0.049 13.7 0.3 0.059 13.4 0.3 1.1 1 0 0 1 1 1 0 UPF0302 domain SRTM1 PF15872.5 EMC80712.1 - 4.5e-53 177.7 10.4 5e-53 177.6 10.4 1.0 1 0 0 1 1 1 1 Serine-rich and transmembrane domain-containing protein 1 Cyclin_N PF00134.23 EMC80713.1 - 1.8e-47 160.2 0.2 3.7e-47 159.2 0.1 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EMC80713.1 - 3.4e-29 101.3 0.8 8.7e-29 100.0 0.2 1.9 2 0 0 2 2 2 1 Cyclin, C-terminal domain Cyclin_C_2 PF16899.5 EMC80713.1 - 0.031 14.7 0.3 0.41 11.1 0.1 2.3 2 0 0 2 2 2 0 Cyclin C-terminal domain DCX PF03607.17 EMC80714.1 - 1.6e-37 127.4 0.1 3.6e-23 81.4 0.0 2.3 2 0 0 2 2 2 2 Doublecortin Pkinase PF00069.25 EMC80715.1 - 3.9e-75 252.6 0.0 5e-75 252.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC80715.1 - 3.5e-34 118.3 0.0 4.4e-34 117.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMC80715.1 - 7.6e-05 22.1 0.0 0.00013 21.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EMC80715.1 - 0.00066 19.1 0.0 0.0015 17.9 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EMC80715.1 - 0.0016 17.3 0.4 0.004 16.0 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 EMC80715.1 - 0.093 12.2 0.0 0.22 11.0 0.0 1.6 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL RIO1 PF01163.22 EMC80715.1 - 0.12 11.9 0.2 0.25 10.9 0.2 1.4 1 0 0 1 1 1 0 RIO1 family CAP_GLY PF01302.25 EMC80716.1 - 4.1e-25 87.6 2.0 5.1e-25 87.3 2.0 1.1 1 0 0 1 1 1 1 CAP-Gly domain Dynactin PF12455.8 EMC80717.1 - 1.5e-46 159.0 2.7 1.5e-46 159.0 2.7 4.5 2 1 0 3 3 2 1 Dynein associated protein TolA_bind_tri PF16331.5 EMC80717.1 - 0.0035 17.4 12.6 0.0035 17.4 12.6 7.1 4 2 1 6 6 4 2 TolA binding protein trimerisation Spc7 PF08317.11 EMC80717.1 - 0.071 12.0 89.4 0.8 8.5 27.6 4.7 1 1 3 4 4 4 0 Spc7 kinetochore protein Phage_GP20 PF06810.11 EMC80717.1 - 0.26 11.1 73.6 0.15 11.8 19.8 4.8 1 1 2 4 4 4 0 Phage minor structural protein GP20 GAS PF13851.6 EMC80717.1 - 0.44 9.9 94.8 0.086 12.2 25.1 5.6 2 1 1 4 4 4 0 Growth-arrest specific micro-tubule binding BRI3BP PF14965.6 EMC80717.1 - 0.53 9.8 3.7 3.3 7.2 0.0 3.5 3 1 0 3 3 3 0 Negative regulator of p53/TP53 Filament PF00038.21 EMC80717.1 - 0.67 9.5 83.8 1.5 8.3 28.1 3.6 1 1 0 2 2 2 0 Intermediate filament protein Fez1 PF06818.15 EMC80717.1 - 2.5 8.5 79.0 0.092 13.2 24.8 3.2 1 1 2 3 3 3 0 Fez1 TPR_MLP1_2 PF07926.12 EMC80717.1 - 6.5 6.8 96.3 4.2 7.5 28.2 5.4 1 1 5 6 6 6 0 TPR/MLP1/MLP2-like protein Seryl_tRNA_N PF02403.22 EMC80717.1 - 7 6.9 76.5 0.13 12.5 18.6 5.3 1 1 3 5 5 5 0 Seryl-tRNA synthetase N-terminal domain NPV_P10 PF05531.12 EMC80717.1 - 8.5 6.9 34.0 0.77 10.3 0.6 6.6 1 1 2 3 3 2 0 Nucleopolyhedrovirus P10 protein Papilloma_E5 PF03025.14 EMC80718.1 - 0.09 13.0 14.4 0.34 11.1 0.1 4.3 3 2 1 4 4 4 0 Papillomavirus E5 Collagen PF01391.18 EMC80719.1 - 9.5e-09 34.9 6.9 0.0049 16.6 0.0 2.9 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Drf_FH1 PF06346.12 EMC80719.1 - 0.0016 18.2 20.5 0.0019 17.9 20.5 1.2 1 0 0 1 1 1 1 Formin Homology Region 1 TRC8_N PF13705.6 EMC80720.1 - 3.7e-63 214.2 13.0 4.1e-63 214.0 13.0 1.0 1 0 0 1 1 1 1 TRC8 N-terminal domain Bac_export_2 PF01312.19 EMC80720.1 - 3.6 6.7 5.7 5.2 6.2 5.7 1.2 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family Gastrin PF00918.17 EMC80721.1 - 5.1e-51 172.9 0.0 5.7e-51 172.7 0.0 1.0 1 0 0 1 1 1 1 Gastrin/cholecystokinin family SUI1 PF01253.22 EMC80722.1 - 3.3e-29 101.2 1.0 4.9e-29 100.7 1.0 1.3 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF2729 PF10870.8 EMC80722.1 - 0.75 9.7 4.6 2.3 8.1 4.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2729) Prolactin_RP PF15172.6 EMC80723.1 - 3.4e-22 77.8 3.8 5.8e-22 77.0 3.8 1.3 1 0 0 1 1 1 1 Prolactin-releasing peptide LEAP-2 PF07359.11 EMC80723.1 - 0.0096 15.7 0.0 0.021 14.6 0.0 1.6 1 0 0 1 1 1 1 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) Rab_eff_C PF04698.12 EMC80724.1 - 1.2e-80 271.8 5.6 1.3e-80 271.7 5.6 1.0 1 0 0 1 1 1 1 Rab effector MyRIP/melanophilin C-terminus FYVE_2 PF02318.16 EMC80725.1 - 2.1e-24 86.0 20.7 2.3e-24 85.9 20.7 1.0 1 0 0 1 1 1 1 FYVE-type zinc finger zf-UDP PF14569.6 EMC80725.1 - 4.8 7.4 15.7 13 5.9 15.2 1.9 1 1 1 2 2 2 0 Zinc-binding RING-finger C1_1 PF00130.22 EMC80725.1 - 6.4 6.7 22.7 2.7 8.0 16.1 2.3 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-piccolo PF05715.13 EMC80725.1 - 9 6.5 22.1 0.075 13.2 11.6 2.1 1 1 0 2 2 2 0 Piccolo Zn-finger TMC PF07810.13 EMC80726.1 - 8.3e-18 65.0 0.6 1.8e-17 63.9 0.6 1.6 1 0 0 1 1 1 1 TMC domain DUF5366 PF17328.2 EMC80726.1 - 0.23 11.6 3.2 0.79 9.8 0.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5366) 40S_SA_C PF16122.5 EMC80727.1 - 1.3e-27 97.0 21.9 2.2e-27 96.2 21.9 1.4 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Ribosomal_S2 PF00318.20 EMC80727.1 - 1.5e-26 93.0 0.0 1.6e-13 50.4 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 Mito_carr PF00153.27 EMC80728.1 - 1.8e-58 194.5 8.2 7.5e-20 70.7 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein TRAPP PF04051.16 EMC80728.1 - 0.024 14.3 0.0 1.4 8.6 0.0 2.4 2 0 0 2 2 2 0 Transport protein particle (TRAPP) component 7tm_1 PF00001.21 EMC80729.1 - 6e-51 173.3 22.1 7.9e-51 172.9 22.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC80729.1 - 0.00046 19.7 21.1 0.00064 19.2 21.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx SNARE PF05739.19 EMC80729.1 - 4.9 7.2 5.2 1.1 9.4 1.4 1.9 1 1 0 1 1 1 0 SNARE domain 7tm_1 PF00001.21 EMC80730.1 - 4.4e-55 186.8 25.1 5.9e-55 186.4 25.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC80730.1 - 1.2e-09 37.9 27.0 1.7e-09 37.4 27.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 60KD_IMP PF02096.20 EMC80730.1 - 0.043 13.7 8.9 1.5 8.7 8.9 2.2 1 1 0 1 1 1 0 60Kd inner membrane protein DUF3325 PF11804.8 EMC80730.1 - 0.12 12.6 1.5 0.24 11.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3325) Metallophos PF00149.28 EMC80731.1 - 6.1e-13 49.7 0.1 8.3e-13 49.3 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EMC80731.1 - 9.3e-06 25.9 0.0 2.1e-05 24.8 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain BTB PF00651.31 EMC80733.1 - 7.5e-29 100.2 3.6 1e-27 96.6 1.0 2.4 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 EMC80733.1 - 1.9e-28 98.6 3.7 1.9e-28 98.6 3.7 2.1 2 0 0 2 2 2 1 BTB And C-terminal Kelch Skp1_POZ PF03931.15 EMC80733.1 - 0.018 15.2 0.0 0.078 13.2 0.0 2.1 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain DUF3342 PF11822.8 EMC80733.1 - 0.024 14.8 0.4 0.2 11.9 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) Kelch_6 PF13964.6 EMC80733.1 - 0.037 14.3 0.0 0.096 13.0 0.0 1.7 1 0 0 1 1 1 0 Kelch motif DUF3819 PF12842.7 EMC80733.1 - 0.11 12.4 1.1 0.69 9.8 0.1 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF3819) CENP-B_dimeris PF09026.10 EMC80734.1 - 0.0025 18.1 5.5 0.0067 16.8 5.5 1.7 1 0 0 1 1 1 1 Centromere protein B dimerisation domain Y_Y_Y PF07495.13 EMC80734.1 - 0.081 12.9 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 Y_Y_Y domain RNA_pol_3_Rpc31 PF11705.8 EMC80734.1 - 1.8 8.8 18.0 0.13 12.5 11.6 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Astro_capsid_p PF12226.8 EMC80734.1 - 9.4 5.3 11.6 15 4.6 9.1 2.1 2 0 0 2 2 2 0 Turkey astrovirus capsid protein FKBP_C PF00254.28 EMC80735.1 - 4.6e-58 193.6 0.1 3.5e-27 94.6 0.0 4.1 4 0 0 4 4 4 2 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_1 PF00036.32 EMC80735.1 - 5e-10 38.2 0.9 0.0003 20.1 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EMC80735.1 - 9.7e-07 29.2 1.0 9.7e-06 25.9 1.0 2.1 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EMC80735.1 - 3.9e-06 26.1 0.5 0.051 13.1 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EMC80735.1 - 5.1e-06 26.0 0.5 0.051 13.5 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 EMC80735.1 - 3.8e-05 23.4 0.1 0.22 11.4 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair DUF3047 PF11249.8 EMC80735.1 - 0.038 13.4 0.0 1.5 8.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3047) UMPH-1 PF05822.12 EMC80736.1 - 5.9e-121 402.6 5.9 7.3e-121 402.3 5.9 1.1 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD PF12710.7 EMC80736.1 - 0.00023 21.6 0.1 0.00046 20.6 0.1 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase ACT_7 PF13840.6 EMC80736.1 - 0.0022 17.7 0.4 6.2 6.7 0.1 3.3 3 0 0 3 3 3 2 ACT domain CIDE-N PF02017.15 EMC80736.1 - 0.017 15.2 0.1 0.35 10.9 0.0 2.6 2 0 0 2 2 2 0 CIDE-N domain NIF PF03031.18 EMC80736.1 - 0.031 14.1 0.1 3.2 7.5 0.0 2.8 1 1 0 2 2 2 0 NLI interacting factor-like phosphatase cNMP_binding PF00027.29 EMC80737.1 - 3.5e-09 36.6 0.1 6e-09 35.9 0.1 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain FeoB_associated PF12669.7 EMC80737.1 - 0.029 14.7 2.7 0.063 13.7 2.7 1.5 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein TNFR_16_TM PF18422.1 EMC80737.1 - 0.042 13.8 0.2 0.079 12.9 0.2 1.4 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain EphA2_TM PF14575.6 EMC80737.1 - 0.15 13.0 0.4 0.24 12.3 0.4 1.4 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain SIT PF15330.6 EMC80737.1 - 0.18 12.2 0.0 0.31 11.5 0.0 1.4 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Vpu PF00558.19 EMC80737.1 - 0.54 10.1 3.1 2.3 8.1 0.1 2.5 3 0 0 3 3 3 0 Vpu protein DAP10 PF07213.11 EMC80737.1 - 1 9.4 2.9 2.5 8.1 0.2 2.5 3 0 0 3 3 3 0 DAP10 membrane protein MRP-L27 PF09809.9 EMC80738.1 - 1.4e-35 121.5 0.0 1.6e-35 121.3 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 WD40 PF00400.32 EMC80739.1 - 6.2e-07 30.0 6.1 0.13 13.2 0.0 4.7 4 0 0 4 4 4 4 WD domain, G-beta repeat HNH_3 PF13392.6 EMC80740.1 - 4.5e-08 32.7 0.6 8.5e-08 31.8 0.6 1.4 1 0 0 1 1 1 1 HNH endonuclease zf-MYND PF01753.18 EMC80740.1 - 4.4e-07 29.9 15.5 8.2e-07 29.0 15.5 1.5 1 0 0 1 1 1 1 MYND finger SHIPPO-rpt PF07004.12 EMC80741.1 - 0.014 16.3 0.0 0.024 15.6 0.0 1.5 1 0 0 1 1 1 0 Sperm-tail PG-rich repeat Ribosomal_L11 PF00298.19 EMC80742.1 - 5.7e-18 65.2 0.1 8e-18 64.7 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 EMC80742.1 - 1e-10 41.2 0.0 1.8e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain FKBP_C PF00254.28 EMC80743.1 - 1.9e-25 89.0 0.0 4.3e-25 87.9 0.0 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase WH1 PF00568.23 EMC80743.1 - 7.9e-05 22.6 0.3 0.00019 21.3 0.3 1.6 1 0 0 1 1 1 1 WH1 domain FPP PF05911.11 EMC80743.1 - 0.0011 17.2 47.8 0.0011 17.2 47.8 2.0 1 1 1 2 2 2 1 Filament-like plant protein, long coiled-coil NPV_P10 PF05531.12 EMC80743.1 - 0.58 10.7 24.6 0.82 10.2 0.4 5.6 2 1 2 5 5 5 0 Nucleopolyhedrovirus P10 protein DUF3568 PF12092.8 EMC80743.1 - 0.69 10.0 7.4 17 5.5 0.0 4.3 4 1 0 4 4 4 0 Protein of unknown function (DUF3568) Filament PF00038.21 EMC80743.1 - 2 7.9 66.1 0.023 14.3 32.5 3.3 1 1 2 3 3 3 0 Intermediate filament protein GAS PF13851.6 EMC80743.1 - 2.4 7.5 72.8 0.28 10.5 35.0 3.7 1 1 3 4 4 4 0 Growth-arrest specific micro-tubule binding Ctr PF04145.15 EMC80744.1 - 7.6e-33 114.2 6.1 1.8e-32 113.0 6.1 1.6 1 1 0 1 1 1 1 Ctr copper transporter family WD40 PF00400.32 EMC80745.1 - 1.6e-41 139.4 20.7 1.6e-08 35.0 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC80745.1 - 2.5e-15 56.5 0.1 0.0065 16.7 0.0 5.4 2 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PRP4 PF08799.11 EMC80745.1 - 2.9e-14 52.3 0.7 2.9e-14 52.3 0.7 2.2 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like WD40_like PF17005.5 EMC80745.1 - 0.00014 21.3 0.0 0.00058 19.3 0.0 2.0 2 0 0 2 2 2 1 WD40-like domain Ge1_WD40 PF16529.5 EMC80745.1 - 0.00044 19.3 0.9 1.8 7.4 0.2 3.9 1 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EMC80745.1 - 0.0044 15.7 1.0 2.2 6.8 0.0 3.9 1 1 2 4 4 4 1 Nucleoporin Nup120/160 WD40 PF00400.32 EMC80746.1 - 1.1e-27 95.7 7.8 0.00021 22.0 0.1 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 EMC80746.1 - 1.7e-06 27.0 0.4 0.15 10.6 0.0 3.9 3 1 1 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EMC80746.1 - 6.5e-06 26.4 0.0 0.25 11.7 0.0 3.7 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 EMC80746.1 - 0.074 13.6 0.6 14 6.3 0.0 3.4 4 1 0 4 4 4 0 PQQ-like domain PSI PF01437.25 EMC80746.1 - 0.27 11.8 3.2 2.9 8.5 0.6 3.0 2 0 0 2 2 2 0 Plexin repeat Cornifin PF02389.15 EMC80747.1 - 0.0014 18.9 56.0 0.16 12.2 19.4 2.1 1 1 1 2 2 2 2 Cornifin (SPRR) family Toxin_12 PF07740.12 EMC80747.1 - 4.5 8.1 50.1 1.5 9.6 1.6 7.2 7 0 0 7 7 7 0 Ion channel inhibitory toxin PRY PF13765.6 EMC80748.1 - 5.4e-11 42.0 0.8 8.6e-11 41.3 0.0 1.8 2 0 0 2 2 2 1 SPRY-associated domain SPRY PF00622.28 EMC80748.1 - 2.3e-09 37.4 0.0 3.5e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 SPRY domain HAD_2 PF13419.6 EMC80749.1 - 1.3e-16 61.2 0.0 1.5e-16 61.0 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EMC80749.1 - 3.6e-13 50.3 0.0 4.4e-13 50.0 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EMC80749.1 - 1.1e-07 31.8 0.0 1.9e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 EMC80749.1 - 0.095 12.8 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase ALAD PF00490.21 EMC80750.1 - 1e-82 277.9 0.0 1.2e-82 277.6 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase CBFD_NFYB_HMF PF00808.23 EMC80751.1 - 2.8e-07 30.7 0.0 5.2e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SpoU_methylase PF00588.19 EMC80751.1 - 0.0068 16.6 0.0 0.0085 16.3 0.0 1.1 1 0 0 1 1 1 1 SpoU rRNA Methylase family Histone PF00125.24 EMC80751.1 - 0.017 15.5 5.9 0.069 13.5 0.0 2.1 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 DUF4746 PF15928.5 EMC80751.1 - 0.061 12.7 8.0 0.062 12.7 8.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Myc_N PF01056.18 EMC80751.1 - 0.077 12.9 6.4 0.073 13.0 6.4 1.1 1 0 0 1 1 1 0 Myc amino-terminal region BUD22 PF09073.10 EMC80751.1 - 0.079 12.3 15.0 0.086 12.2 15.0 1.1 1 0 0 1 1 1 0 BUD22 Pox_Ag35 PF03286.14 EMC80751.1 - 0.11 12.3 10.7 0.12 12.2 10.7 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein NOA36 PF06524.12 EMC80751.1 - 0.22 10.8 11.3 0.22 10.8 11.3 1.1 1 0 0 1 1 1 0 NOA36 protein CobT PF06213.12 EMC80751.1 - 0.31 10.4 16.1 0.36 10.2 16.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Afi1 PF07792.12 EMC80751.1 - 0.35 11.3 12.3 0.49 10.9 12.3 1.3 1 1 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CDC45 PF02724.14 EMC80751.1 - 0.63 8.3 9.8 0.59 8.4 9.8 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2956 PF11169.8 EMC80751.1 - 0.89 9.8 8.1 1.4 9.2 8.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) DUF913 PF06025.12 EMC80751.1 - 1.1 8.2 4.1 0.97 8.3 4.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) V_ATPase_I PF01496.19 EMC80751.1 - 1.3 6.9 4.2 1.2 7.0 4.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Vfa1 PF08432.10 EMC80751.1 - 1.3 9.3 14.1 1.5 9.1 14.1 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RPN2_C PF18004.1 EMC80751.1 - 1.3 8.9 11.9 1.4 8.8 11.9 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Presenilin PF01080.17 EMC80751.1 - 1.4 7.6 5.8 1.4 7.6 5.8 1.1 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 EMC80751.1 - 1.5 8.5 3.7 1.5 8.6 3.7 1.2 1 0 0 1 1 1 0 Connexin DNA_pol_phi PF04931.13 EMC80751.1 - 1.7 6.7 21.8 2 6.4 21.8 1.0 1 0 0 1 1 1 0 DNA polymerase phi NPR3 PF03666.13 EMC80751.1 - 2.8 6.6 8.0 3.1 6.5 8.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RGS PF00615.19 EMC80752.1 - 2.1e-38 131.2 4.1 2.8e-38 130.8 4.1 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain zf-C2H2_4 PF13894.6 EMC80753.1 - 1.4e-09 38.0 23.4 0.029 15.2 2.3 5.4 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC80753.1 - 1e-07 32.0 28.3 0.13 12.8 2.9 5.4 4 0 0 4 4 4 4 Zinc finger, C2H2 type Dimer_Tnp_hAT PF05699.14 EMC80753.1 - 2.1e-05 24.2 0.2 6.3e-05 22.7 0.2 1.9 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region zf-C2H2_3rep PF18868.1 EMC80753.1 - 0.022 15.5 4.6 0.76 10.5 0.1 3.2 2 1 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats DBD_Tnp_Hermes PF10683.9 EMC80753.1 - 0.077 12.7 0.0 0.19 11.5 0.0 1.7 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain DUF4413 PF14372.6 EMC80753.1 - 0.1 13.0 0.0 0.26 11.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) zf_UBZ PF18439.1 EMC80753.1 - 0.15 11.7 14.1 0.53 9.9 1.3 4.5 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf-BED PF02892.15 EMC80753.1 - 0.99 9.5 24.1 1.4 9.0 2.5 4.9 5 0 0 5 5 5 0 BED zinc finger C1_2 PF03107.16 EMC80753.1 - 6.1 7.2 33.7 1.2 9.5 4.6 5.2 4 1 1 5 5 5 0 C1 domain RNA_pol_Rpb1_1 PF04997.12 EMC80753.1 - 7.3 5.8 10.4 4.3 6.6 0.4 3.5 2 2 1 3 3 3 0 RNA polymerase Rpb1, domain 1 Lig_chan PF00060.26 EMC80754.1 - 1.3e-38 132.2 0.1 2.2e-38 131.4 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel ANF_receptor PF01094.28 EMC80754.1 - 4.9e-33 114.7 0.0 4.2e-31 108.3 0.0 2.3 1 1 0 1 1 1 1 Receptor family ligand binding region Lig_chan-Glu_bd PF10613.9 EMC80754.1 - 7.9e-32 109.9 0.1 4.1e-30 104.3 0.0 2.5 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 EMC80754.1 - 2.2e-19 69.8 0.0 4.9e-19 68.7 0.0 1.6 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 CaM_bdg_C0 PF10562.9 EMC80754.1 - 1e-13 51.0 3.9 2.3e-13 49.9 3.9 1.6 1 0 0 1 1 1 1 Calmodulin-binding domain C0 of NMDA receptor NR1 subunit Peripla_BP_6 PF13458.6 EMC80754.1 - 0.022 14.4 0.0 0.8 9.3 0.0 2.2 2 0 0 2 2 2 0 Periplasmic binding protein Ion_trans_2 PF07885.16 EMC80754.1 - 0.025 14.5 0.6 0.068 13.1 0.6 1.7 1 0 0 1 1 1 0 Ion channel LRR_8 PF13855.6 EMC80755.1 - 5.4e-25 86.9 13.1 8.4e-14 51.1 3.7 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EMC80755.1 - 7.2e-11 42.2 5.5 5.8e-06 26.6 1.5 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRRNT PF01462.18 EMC80755.1 - 3e-10 39.5 3.0 9e-10 38.0 3.0 1.9 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 EMC80755.1 - 2.5e-07 30.3 9.5 0.063 13.9 0.1 5.1 5 0 0 5 5 5 3 Leucine Rich Repeat LRR_9 PF14580.6 EMC80755.1 - 0.00037 20.0 0.1 0.0037 16.8 0.0 1.9 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 EMC80755.1 - 0.016 15.2 6.7 2.4 8.4 0.4 3.5 3 0 0 3 3 3 0 Leucine Rich repeat TPKR_C2 PF16920.5 EMC80755.1 - 0.028 14.6 2.1 0.09 12.9 1.4 2.1 2 0 0 2 2 2 0 Tyrosine-protein kinase receptor C2 Ig-like domain zf-RING_UBOX PF13445.6 EMC80756.1 - 0.0028 17.6 10.5 0.0028 17.6 10.5 2.5 2 1 1 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMC80756.1 - 0.0029 17.6 16.5 0.0029 17.5 13.9 2.4 2 1 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC80756.1 - 0.004 17.0 15.9 0.012 15.4 13.7 2.6 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EMC80756.1 - 0.0044 17.3 11.8 0.0044 17.3 11.8 1.9 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EMC80756.1 - 0.032 14.1 14.3 0.032 14.1 14.3 2.2 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) GcpE PF04551.14 EMC80756.1 - 0.28 10.2 5.5 1 8.4 5.5 1.8 1 1 0 1 1 1 0 GcpE protein Zn_Tnp_IS1595 PF12760.7 EMC80756.1 - 0.83 9.7 11.4 2.6 8.1 2.2 2.8 2 1 1 3 3 3 0 Transposase zinc-ribbon domain FYVE PF01363.21 EMC80756.1 - 3.3 7.9 11.8 8.9 6.5 11.8 1.9 1 1 0 1 1 1 0 FYVE zinc finger ADK_lid PF05191.14 EMC80756.1 - 7.6 6.6 9.5 0.4 10.7 1.5 2.7 3 0 0 3 3 3 0 Adenylate kinase, active site lid Anti-TRAP PF15777.5 EMC80756.1 - 9 6.3 8.2 6 6.9 0.7 2.4 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein zf-RING_2 PF13639.6 EMC80759.1 - 4.8e-10 39.6 5.8 8e-10 38.9 5.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EMC80759.1 - 2.5e-09 36.8 5.7 4.2e-09 36.1 5.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC80759.1 - 4.5e-09 36.1 5.4 6.7e-09 35.6 5.4 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EMC80759.1 - 2.4e-08 33.9 6.8 2.5e-08 33.8 2.3 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EMC80759.1 - 4.4e-08 32.9 7.3 1.1e-07 31.5 7.3 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMC80759.1 - 1.2e-06 28.5 3.3 3.1e-06 27.3 3.3 1.7 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EMC80759.1 - 2.2e-06 27.4 9.2 0.0001 22.1 9.7 2.5 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 EMC80759.1 - 9.6e-06 25.3 6.5 1.8e-05 24.5 6.5 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 EMC80759.1 - 0.0013 18.8 2.1 0.0018 18.3 2.1 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EMC80759.1 - 0.0017 18.6 4.1 0.0017 18.6 3.2 1.5 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EMC80759.1 - 0.0039 17.0 11.0 0.051 13.4 11.3 2.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) NMD3 PF04981.13 EMC80759.1 - 0.0071 15.8 2.2 0.008 15.7 2.2 1.0 1 0 0 1 1 1 1 NMD3 family zf-RING_11 PF17123.5 EMC80759.1 - 0.022 14.5 0.5 0.022 14.5 0.5 2.4 3 0 0 3 3 3 0 RING-like zinc finger Gin PF10764.9 EMC80759.1 - 0.074 13.0 0.3 0.074 13.0 0.3 2.2 2 0 0 2 2 2 0 Inhibitor of sigma-G Gin zf-Sec23_Sec24 PF04810.15 EMC80759.1 - 0.1 12.7 3.2 0.37 10.9 1.2 2.4 2 1 0 2 2 2 0 Sec23/Sec24 zinc finger zf-P11 PF03854.14 EMC80759.1 - 0.18 11.5 11.1 0.82 9.4 4.6 2.9 1 1 1 2 2 2 0 P-11 zinc finger zf-RING_10 PF16685.5 EMC80759.1 - 0.22 11.7 7.2 0.6 10.3 7.2 1.8 1 1 0 1 1 1 0 zinc RING finger of MSL2 Baculo_IE-1 PF05290.11 EMC80759.1 - 0.37 10.8 3.6 0.48 10.4 3.6 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Zn-C2H2_12 PF18112.1 EMC80759.1 - 0.4 11.2 4.1 3.4 8.2 0.3 2.4 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain DUF4428 PF14471.6 EMC80759.1 - 0.62 10.0 0.2 0.62 10.0 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4428) DZR PF12773.7 EMC80759.1 - 0.95 9.5 7.3 13 5.9 7.4 2.2 1 1 0 1 1 1 0 Double zinc ribbon zf-WRNIP1_ubi PF18279.1 EMC80759.1 - 1.1 10.0 6.4 1.3 9.9 0.3 2.8 2 1 0 2 2 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain YacG PF03884.14 EMC80759.1 - 1.1 9.0 7.2 5.4 6.8 1.1 2.3 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG DUF3090 PF11290.8 EMC80759.1 - 1.6 8.5 6.2 3.4 7.5 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3090) zf-C2H2_4 PF13894.6 EMC80759.1 - 4.9 8.3 7.4 4.2 8.5 0.3 2.9 2 1 0 2 2 2 0 C2H2-type zinc finger zf-Di19 PF05605.12 EMC80759.1 - 8.1 6.8 9.2 12 6.3 2.4 2.4 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Tmemb_185A PF10269.9 EMC80760.1 - 1.6e-07 31.3 5.0 1.6e-07 31.3 5.0 1.4 1 1 0 1 1 1 1 Transmembrane Fragile-X-F protein GDA1_CD39 PF01150.17 EMC80761.1 - 2.3e-107 359.3 0.0 2.9e-107 359.0 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family GDA1_CD39 PF01150.17 EMC80762.1 - 5.9e-106 354.7 0.0 7.6e-106 354.3 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Adeno_E3_CR2 PF02439.15 EMC80762.1 - 0.25 11.1 1.4 0.48 10.2 1.4 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 GDA1_CD39 PF01150.17 EMC80763.1 - 5.4e-104 348.2 0.0 6.6e-104 347.9 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family SH3_1 PF00018.28 EMC80764.1 - 4.2e-16 58.3 0.0 1.6e-12 46.9 0.0 2.5 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 EMC80764.1 - 1e-10 41.3 0.0 2.3e-08 33.8 0.0 2.6 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EMC80764.1 - 2.2e-09 36.8 0.0 8.7e-06 25.3 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain PB1 PF00564.24 EMC80764.1 - 6.4e-07 29.2 0.0 1.6e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 PB1 domain TPR_2 PF07719.17 EMC80764.1 - 7.2e-07 28.9 0.5 0.025 14.7 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMC80764.1 - 1.7e-05 24.4 0.1 0.0011 18.7 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMC80764.1 - 0.0039 17.5 0.8 2.1 8.7 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 EMC80764.1 - 0.0049 17.0 0.8 1.9 8.7 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMC80764.1 - 0.048 13.7 0.3 2 8.7 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMC80764.1 - 0.28 11.9 1.3 3.6 8.4 0.3 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat BRO1 PF03097.18 EMC80765.1 - 2.5e-92 309.7 5.6 2.5e-92 309.7 5.6 1.9 2 1 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EMC80765.1 - 4.2e-87 292.2 18.6 4.2e-87 292.2 18.6 2.0 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV Patatin PF01734.22 EMC80765.1 - 0.034 14.3 0.7 0.13 12.4 0.0 2.3 2 1 0 2 2 2 0 Patatin-like phospholipase Importin_rep_6 PF18829.1 EMC80765.1 - 0.063 13.4 3.6 0.074 13.2 0.1 2.6 2 0 0 2 2 2 0 Importin repeat 6 T2SSM PF04612.12 EMC80765.1 - 0.33 11.0 6.4 1.4 8.9 0.2 2.8 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein M Med10 PF09748.9 EMC80765.1 - 0.39 10.7 5.1 0.24 11.4 1.5 2.5 2 0 0 2 2 2 0 Transcription factor subunit Med10 of Mediator complex HbrB PF08539.11 EMC80765.1 - 0.93 9.5 3.5 2.9 7.8 0.4 2.8 2 1 1 3 3 3 0 HbrB-like DUF592 PF04574.13 EMC80765.1 - 1.5 8.5 8.3 6.2 6.6 0.1 3.5 2 1 2 4 4 4 0 Protein of unknown function (DUF592) DUF3510 PF12022.8 EMC80765.1 - 1.8 8.9 8.1 9 6.7 2.9 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF3510) YebO PF13974.6 EMC80765.1 - 5.7 7.1 6.7 4.5 7.4 3.4 2.6 2 0 0 2 2 2 0 YebO-like protein NHL PF01436.21 EMC80766.1 - 6e-26 89.1 3.0 0.00048 20.0 0.0 6.8 7 0 0 7 7 7 6 NHL repeat SGL PF08450.12 EMC80766.1 - 0.014 15.0 0.0 0.14 11.7 0.0 2.7 1 1 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region Kinesin PF00225.23 EMC80767.1 - 1.3e-109 366.2 0.3 2.1e-109 365.5 0.3 1.4 1 0 0 1 1 1 1 Kinesin motor domain DUF3694 PF12473.8 EMC80767.1 - 7.2e-30 104.7 0.1 7.9e-29 101.3 0.1 2.6 1 1 0 1 1 1 1 Kinesin protein Kinesin_assoc PF16183.5 EMC80767.1 - 5.2e-25 88.6 20.8 8e-20 71.7 1.8 3.9 3 1 1 4 4 4 2 Kinesin-associated Microtub_bd PF16796.5 EMC80767.1 - 8.9e-23 80.9 0.1 2.5e-22 79.4 0.1 1.9 1 0 0 1 1 1 1 Microtubule binding KIF1B PF12423.8 EMC80767.1 - 1.3e-16 60.7 0.0 4.6e-16 59.0 0.0 2.1 1 0 0 1 1 1 1 Kinesin protein 1B FHA PF00498.26 EMC80767.1 - 9.1e-05 22.7 0.1 0.0014 18.9 0.0 2.5 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 EMC80767.1 - 0.005 17.1 0.0 0.017 15.4 0.0 1.9 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain C2-C2_1 PF11618.8 EMC80767.1 - 0.11 12.6 0.3 3.7 7.6 0.1 2.8 2 1 0 2 2 2 0 First C2 domain of RPGR-interacting protein 1 KMP11 PF03037.16 EMC80767.1 - 0.35 11.7 6.7 0.22 12.3 1.4 2.9 2 0 0 2 2 2 0 Kinetoplastid membrane protein 11 Creatinase_N PF01321.18 EMC80767.1 - 0.67 10.6 2.9 1.6 9.4 0.1 3.1 3 1 0 3 3 3 0 Creatinase/Prolidase N-terminal domain Exonuc_VII_L PF02601.15 EMC80767.1 - 4.8 6.7 13.9 1.1 8.7 0.4 2.7 2 0 0 2 2 2 0 Exonuclease VII, large subunit Fib_alpha PF08702.10 EMC80767.1 - 7.9 6.7 16.5 9.5 6.4 2.0 4.1 4 0 0 4 4 4 0 Fibrinogen alpha/beta chain family SIR2 PF02146.17 EMC80768.1 - 1.3e-49 168.5 0.0 2.9e-49 167.4 0.0 1.5 1 1 0 1 1 1 1 Sir2 family PNTB PF02233.16 EMC80768.1 - 0.00039 19.5 0.1 0.011 14.6 0.1 2.0 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit TPP_enzyme_M PF00205.22 EMC80768.1 - 0.069 12.9 0.0 10 5.8 0.0 2.7 3 0 0 3 3 3 0 Thiamine pyrophosphate enzyme, central domain DZR PF12773.7 EMC80768.1 - 1 9.5 4.4 1.9 8.6 0.1 3.2 4 0 0 4 4 4 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 EMC80768.1 - 8.7 6.2 8.2 11 5.8 1.2 3.0 3 0 0 3 3 3 0 zinc-ribbon domain NUC129 PF08157.11 EMC80769.1 - 8e-30 103.0 0.0 1.4e-29 102.3 0.0 1.4 1 0 0 1 1 1 1 NUC129 domain CLTH PF10607.9 EMC80770.1 - 4.6e-48 162.9 0.0 6.6e-48 162.4 0.0 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.28 EMC80770.1 - 1.9e-25 89.3 0.2 4e-25 88.3 0.2 1.6 1 0 0 1 1 1 1 SPRY domain LisH PF08513.11 EMC80770.1 - 1.3e-06 28.1 0.0 3e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 LisH DUF1640 PF07798.11 EMC80771.1 - 1.3e-57 194.6 11.0 1.5e-56 191.2 11.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1640) HALZ PF02183.18 EMC80771.1 - 0.014 15.6 4.2 0.017 15.4 1.9 2.1 2 0 0 2 2 2 0 Homeobox associated leucine zipper YabA PF06156.13 EMC80771.1 - 0.43 11.2 7.8 1.8 9.2 7.2 2.3 1 1 0 1 1 1 0 Initiation control protein YabA FlaC_arch PF05377.11 EMC80771.1 - 1.9 9.0 7.0 5.5 7.5 3.7 3.0 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Phage_GP20 PF06810.11 EMC80771.1 - 5.6 6.8 13.4 1.1 9.0 8.0 2.0 2 0 0 2 2 2 0 Phage minor structural protein GP20 zf-RING_2 PF13639.6 EMC80772.1 - 9e-06 25.9 12.7 9e-06 25.9 12.7 2.1 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 EMC80772.1 - 0.00016 21.5 13.2 0.00016 21.5 13.2 1.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EMC80772.1 - 0.004 17.1 10.2 0.015 15.3 10.2 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EMC80772.1 - 0.01 15.7 13.2 0.026 14.4 13.2 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Dysbindin PF04440.16 EMC80773.1 - 2.6e-67 225.5 9.8 5.7e-67 224.4 9.8 1.6 1 0 0 1 1 1 1 Dysbindin (Dystrobrevin binding protein 1) FERM_M PF00373.18 EMC80774.1 - 1.2e-17 64.4 2.4 2.7e-17 63.2 2.4 1.6 1 0 0 1 1 1 1 FERM central domain zf-C3HC4_3 PF13920.6 EMC80774.1 - 1.7e-10 40.6 20.3 4.1e-10 39.4 20.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FERM_N PF09379.10 EMC80774.1 - 1.6e-09 37.5 0.0 3.8e-09 36.4 0.0 1.7 1 0 0 1 1 1 1 FERM N-terminal domain FERM_C PF09380.10 EMC80774.1 - 0.00013 22.2 0.0 0.00051 20.4 0.0 2.0 2 1 0 2 2 2 1 FERM C-terminal PH-like domain Prok-RING_4 PF14447.6 EMC80774.1 - 0.022 14.6 21.1 0.063 13.2 21.1 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Rab_eff_C PF04698.12 EMC80774.1 - 2.6 6.2 6.0 0.19 10.0 0.6 1.7 2 0 0 2 2 2 0 Rab effector MyRIP/melanophilin C-terminus IMPDH PF00478.25 EMC80775.1 - 1.6e-75 254.2 2.5 1.1e-74 251.5 2.5 2.2 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EMC80775.1 - 0.00011 21.3 1.0 0.00018 20.6 1.0 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 EMC80775.1 - 0.064 12.4 0.5 0.1 11.7 0.5 1.3 1 0 0 1 1 1 0 Conserved region in glutamate synthase RDD PF06271.12 EMC80776.1 - 4.2e-12 46.5 5.0 1.1e-10 41.9 5.0 2.0 1 1 0 1 1 1 1 RDD family Nup153 PF08604.10 EMC80777.1 - 1.7e-127 426.4 23.3 1.7e-127 426.4 23.3 4.7 4 1 1 6 6 6 1 Nucleoporin Nup153-like zf-RanBP PF00641.18 EMC80777.1 - 1.5e-34 116.9 39.5 3.3e-12 45.5 3.1 4.6 5 0 0 5 5 5 4 Zn-finger in Ran binding protein and others Trnau1ap PF17654.1 EMC80778.1 - 1.3e-31 109.5 15.4 1.3e-31 109.5 15.4 1.6 2 0 0 2 2 2 1 Selenocysteine tRNA 1 associated proteins RRM_1 PF00076.22 EMC80778.1 - 6.8e-10 38.6 0.0 1.4e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4929 PF16283.5 EMC80778.1 - 0.29 10.1 4.3 0.41 9.6 4.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4929) WD40 PF00400.32 EMC80779.1 - 1.9e-23 82.3 4.7 3.4e-06 27.7 0.4 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC80779.1 - 3.8e-08 33.5 1.6 0.11 12.8 0.0 5.0 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC80779.1 - 4.5e-06 26.7 0.4 0.095 12.6 0.2 2.4 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.6 EMC80779.1 - 2.1e-05 24.5 0.3 0.03 14.4 0.1 3.0 2 1 1 3 3 3 2 Ciliary BBSome complex subunit 2, middle region Ge1_WD40 PF16529.5 EMC80779.1 - 2.3e-05 23.5 4.2 0.004 16.1 0.5 2.8 1 1 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EMC80779.1 - 0.0028 16.4 3.0 0.2 10.2 0.2 3.1 2 1 0 3 3 3 2 Nucleoporin Nup120/160 Vps16_N PF04841.13 EMC80779.1 - 0.005 15.7 0.2 0.0093 14.8 0.2 1.5 1 1 0 1 1 1 1 Vps16, N-terminal region WD40_like PF17005.5 EMC80779.1 - 0.02 14.2 2.9 0.57 9.5 0.0 2.7 1 1 0 2 2 2 0 WD40-like domain RNA_pol_Rpc4 PF05132.14 EMC80779.1 - 1.6 9.1 7.7 12 6.3 0.0 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 Tmemb_14 PF03647.13 EMC80780.1 - 7.8e-30 103.5 9.8 8.8e-30 103.3 9.8 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C CytB6-F_Fe-S PF08802.10 EMC80780.1 - 0.11 12.5 4.4 1.6 8.8 0.2 2.9 3 0 0 3 3 3 0 Cytochrome B6-F complex Fe-S subunit GFO_IDH_MocA_C PF02894.17 EMC80781.1 - 0.036 14.1 0.2 0.078 13.0 0.2 1.6 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain RabGAP-TBC PF00566.18 EMC80782.1 - 2.8e-06 27.1 6.3 6.1e-05 22.8 4.3 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain DrrA_P4M PF14860.6 EMC80782.1 - 0.058 13.2 0.1 0.17 11.7 0.0 1.8 2 0 0 2 2 2 0 DrrA phosphatidylinositol 4-phosphate binding domain RPEL PF02755.15 EMC80783.1 - 2.6e-32 109.6 29.0 2.5e-09 36.5 2.9 4.6 4 0 0 4 4 4 4 RPEL repeat Sod_Ni PF09055.11 EMC80783.1 - 0.078 13.5 0.6 0.19 12.3 0.6 1.6 1 0 0 1 1 1 0 Nickel-containing superoxide dismutase Endothelin PF00322.17 EMC80784.1 - 2.6e-23 81.3 14.2 1.3e-20 72.7 4.0 2.7 2 0 0 2 2 2 2 Endothelin family PIN_3 PF13470.6 EMC80784.1 - 0.067 14.0 0.0 0.1 13.4 0.0 1.4 1 0 0 1 1 1 0 PIN domain zf-C2H2 PF00096.26 EMC80785.1 - 2.7e-18 65.3 41.1 0.00016 21.9 1.6 6.1 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC80785.1 - 2.1e-09 37.4 11.0 9.6e-07 29.0 0.6 5.6 6 0 0 6 6 6 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC80785.1 - 2.3e-07 31.1 35.5 0.041 14.7 1.8 6.1 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC80785.1 - 3.1e-06 27.3 41.1 0.014 15.7 1.4 6.0 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 EMC80785.1 - 8.4e-05 22.2 34.4 0.00095 18.9 5.8 5.9 5 0 0 5 5 5 3 C2H2-type zinc-finger domain NOA36 PF06524.12 EMC80785.1 - 0.0022 17.4 23.7 0.014 14.8 1.1 3.2 3 0 0 3 3 3 2 NOA36 protein zf-met PF12874.7 EMC80785.1 - 7.2 7.1 43.1 1.5 9.3 0.5 5.8 6 0 0 6 6 6 0 Zinc-finger of C2H2 type Far-17a_AIG1 PF04750.14 EMC80786.1 - 6.7e-60 201.9 17.5 7.8e-60 201.7 17.5 1.0 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein Tmemb_170 PF10190.9 EMC80787.1 - 1.8e-35 121.5 12.7 2e-35 121.4 12.7 1.0 1 0 0 1 1 1 1 Putative transmembrane protein 170 Gly_kinase PF02595.15 EMC80787.1 - 0.0087 15.1 0.0 0.0091 15.0 0.0 1.0 1 0 0 1 1 1 1 Glycerate kinase family CAS_C PF12026.8 EMC80788.1 - 1.9e-83 279.7 7.6 2.3e-83 279.4 6.0 2.0 2 0 0 2 2 2 1 Crk-Associated Substrate C-terminal domain Serine_rich PF08824.10 EMC80788.1 - 4.2e-58 195.8 3.6 4.2e-58 195.8 3.6 2.7 3 0 0 3 3 3 1 Serine rich protein interaction domain SH3_9 PF14604.6 EMC80788.1 - 2.3e-13 49.8 0.0 4.2e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC80788.1 - 1.5e-11 43.7 0.0 2.7e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC80788.1 - 7.1e-11 41.6 0.0 1.2e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain ELO PF01151.18 EMC80789.1 - 4.9e-62 209.7 22.2 5.8e-62 209.5 22.2 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family GCM PF03615.15 EMC80790.1 - 2.4e-72 241.3 1.4 3.6e-72 240.8 1.4 1.3 1 0 0 1 1 1 1 GCM motif protein FixO PF02433.15 EMC80790.1 - 0.11 11.9 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 Cytochrome C oxidase, mono-heme subunit/FixO Pkinase PF00069.25 EMC80791.1 - 1.2e-76 257.6 0.0 1.5e-76 257.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC80791.1 - 1.4e-35 122.8 0.2 7e-35 120.6 0.2 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Tmemb_14 PF03647.13 EMC80792.1 - 8.9e-18 64.8 2.3 9.9e-18 64.7 2.3 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C DUF308 PF03729.13 EMC80792.1 - 0.033 14.5 1.4 0.051 13.9 0.1 1.7 2 0 0 2 2 2 0 Short repeat of unknown function (DUF308) ETRAMP PF09716.10 EMC80792.1 - 2.4 8.3 5.4 4.7 7.3 0.3 2.7 1 1 2 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) Branch PF02485.21 EMC80793.1 - 4.6e-56 190.1 0.0 8.5e-56 189.2 0.0 1.4 2 0 0 2 2 2 1 Core-2/I-Branching enzyme TF_AP-2 PF03299.14 EMC80794.1 - 4.4e-56 190.0 0.0 5.1e-56 189.8 0.0 1.1 1 0 0 1 1 1 1 Transcription factor AP-2 Peptidase_Prp PF04327.12 EMC80794.1 - 0.023 14.9 0.0 0.38 11.0 0.0 2.1 2 0 0 2 2 2 0 Cysteine protease Prp DUF2624 PF11116.8 EMC80794.1 - 0.03 15.2 0.0 0.05 14.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2624) OFCC1 PF15680.5 EMC80795.1 - 3.4e-59 198.1 2.5 5.1e-59 197.6 2.5 1.3 1 0 0 1 1 1 1 Orofacial cleft 1 candidate gene 1 protein DUF3674 PF12426.8 EMC80795.1 - 0.078 13.0 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 RNA dependent RNA polymerase AA_kinase PF00696.28 EMC80795.1 - 0.082 12.5 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Amino acid kinase family DUF4653 PF15546.6 EMC80796.1 - 1.1e-21 77.7 0.9 1.2e-21 77.5 0.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4653) UAA PF08449.11 EMC80797.1 - 2.4e-95 319.2 24.2 2.9e-95 318.9 24.2 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 EMC80797.1 - 0.0052 17.0 31.4 0.0087 16.2 16.3 2.7 2 1 1 3 3 3 2 EamA-like transporter family GST_C PF00043.25 EMC80798.1 - 6.6e-08 32.7 0.2 1.5e-07 31.6 0.2 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EMC80798.1 - 9.4e-06 25.8 0.4 2.1e-05 24.7 0.1 1.8 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EMC80798.1 - 0.0002 21.3 0.1 0.00048 20.1 0.1 2.0 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EMC80798.1 - 0.067 13.0 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Muted PF14942.6 EMC80799.1 - 2.8e-56 189.9 15.3 3.1e-56 189.8 15.3 1.0 1 0 0 1 1 1 1 Organelle biogenesis, Muted-like protein DUF148 PF02520.17 EMC80799.1 - 0.0048 17.0 5.0 0.012 15.7 2.2 2.2 1 1 1 2 2 2 1 Domain of unknown function DUF148 EST1_DNA_bind PF10373.9 EMC80799.1 - 0.017 14.6 0.3 0.021 14.3 0.3 1.1 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain GSH-S_N PF02951.14 EMC80799.1 - 0.15 12.1 2.1 0.22 11.6 2.1 1.2 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, N-terminal domain AAA_11 PF13086.6 EMC80799.1 - 0.2 11.4 6.1 0.2 11.4 6.1 1.1 1 0 0 1 1 1 0 AAA domain FliD_C PF07195.12 EMC80799.1 - 0.22 10.9 4.1 0.16 11.4 1.9 1.5 1 1 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Cytochrom_NNT PF03264.14 EMC80799.1 - 0.28 10.9 5.4 0.41 10.3 5.4 1.3 1 0 0 1 1 1 0 NapC/NirT cytochrome c family, N-terminal region TBCC_N PF16752.5 EMC80799.1 - 0.65 10.5 13.3 13 6.3 0.1 2.6 2 2 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain UMPH-1 PF05822.12 EMC80799.1 - 3 7.3 6.4 5.1 6.5 6.4 1.4 1 1 0 1 1 1 0 Pyrimidine 5'-nucleotidase (UMPH-1) Exonuc_VII_L PF02601.15 EMC80799.1 - 5.4 6.5 6.8 5.9 6.4 6.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mitofilin PF09731.9 EMC80799.1 - 9 5.0 22.0 7.7 5.2 21.0 1.3 1 1 0 1 1 1 0 Mitochondrial inner membrane protein Thioredoxin PF00085.20 EMC80800.1 - 6.9e-82 270.1 0.0 3.4e-29 100.8 0.0 3.0 3 0 0 3 3 3 3 Thioredoxin OST3_OST6 PF04756.13 EMC80800.1 - 5.8e-13 48.8 0.2 0.0038 16.6 0.0 3.1 3 0 0 3 3 3 3 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EMC80800.1 - 7.1e-13 49.0 1.2 0.0062 17.0 0.1 3.6 3 1 0 3 3 3 3 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EMC80800.1 - 3e-08 33.9 0.3 0.84 10.0 0.0 5.0 3 3 2 5 5 5 2 Thioredoxin-like HyaE PF07449.11 EMC80800.1 - 2.1e-07 30.9 0.0 0.0064 16.4 0.0 3.2 3 0 0 3 3 3 2 Hydrogenase-1 expression protein HyaE TraF PF13728.6 EMC80800.1 - 2.1e-05 24.5 4.0 0.41 10.4 0.0 4.0 3 2 1 4 4 4 3 F plasmid transfer operon protein AhpC-TSA PF00578.21 EMC80800.1 - 0.0031 17.4 0.6 1.1 9.2 0.0 2.6 3 0 0 3 3 3 2 AhpC/TSA family Thioredoxin_7 PF13899.6 EMC80800.1 - 0.0045 17.1 1.7 6.9 6.9 0.1 3.5 3 0 0 3 3 3 1 Thioredoxin-like Thioredoxin_3 PF13192.6 EMC80800.1 - 0.007 16.4 0.1 13 5.9 0.0 3.2 3 0 0 3 3 3 1 Thioredoxin domain Thioredoxin_9 PF14595.6 EMC80800.1 - 0.011 15.5 0.2 4.1 7.2 0.1 2.2 2 0 0 2 2 2 0 Thioredoxin TGFb_propeptide PF00688.18 EMC80801.1 - 1.8e-61 208.0 0.0 2.8e-61 207.4 0.0 1.3 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 EMC80801.1 - 8.6e-39 132.7 0.9 2.2e-38 131.4 0.9 1.7 1 0 0 1 1 1 1 Transforming growth factor beta like domain YafO_toxin PF13957.6 EMC80801.1 - 0.04 14.0 0.0 0.19 11.8 0.0 2.1 2 0 0 2 2 2 0 Toxin YafO, type II toxin-antitoxin system RIO1 PF01163.22 EMC80802.1 - 9.4e-76 253.6 0.3 9.4e-76 253.6 0.3 1.9 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 EMC80802.1 - 0.0093 15.9 0.0 0.084 12.8 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family TRAP_alpha PF03896.16 EMC80803.1 - 3.8e-118 393.8 1.0 4.4e-118 393.6 1.0 1.0 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit zf-C2H2 PF00096.26 EMC80804.1 - 3.3e-43 143.8 132.0 7.9e-05 22.9 2.5 17.4 18 0 0 18 18 17 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC80804.1 - 1.2e-39 131.5 122.2 0.00045 20.8 1.1 17.0 17 0 0 17 17 17 15 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC80804.1 - 5.7e-34 115.0 113.3 5e-08 33.0 1.1 19.3 20 0 0 20 20 20 8 Zinc-finger double domain zf-met PF12874.7 EMC80804.1 - 1.1e-10 41.6 77.8 0.014 15.7 0.3 13.1 13 0 0 13 13 12 8 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 EMC80804.1 - 8.2e-10 38.3 64.4 2.4e-07 30.4 0.0 11.6 12 0 0 12 12 12 5 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 EMC80804.1 - 3.6e-09 36.7 47.9 0.064 13.6 1.5 12.6 13 0 0 13 13 13 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMC80804.1 - 4.8e-09 36.0 104.7 2.5e-05 24.2 0.1 16.1 18 0 0 18 18 18 6 C2H2-type zinc finger zf-Di19 PF05605.12 EMC80804.1 - 0.0034 17.6 5.1 0.0034 17.6 5.1 9.7 7 5 3 10 10 9 4 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.5 EMC80804.1 - 0.0088 16.3 0.6 0.0088 16.3 0.6 7.1 8 0 0 8 8 7 3 C2H2-type zinc ribbon RBR PF17208.3 EMC80804.1 - 1.8 9.3 8.4 0.13 13.0 1.0 3.0 2 0 0 2 2 2 0 RNA binding Region zf-C2HC_2 PF13913.6 EMC80804.1 - 5.6 7.0 34.2 0.3 11.0 0.3 8.5 8 0 0 8 8 8 0 zinc-finger of a C2HC-type E1_DerP2_DerF2 PF02221.15 EMC80806.1 - 4.2e-08 33.7 0.3 7.2e-08 32.9 0.2 1.5 1 1 1 2 2 2 1 ML domain Transglut_N PF00868.20 EMC80807.1 - 2.2e-35 121.5 0.2 2.8e-33 114.8 0.0 3.1 3 0 0 3 3 3 1 Transglutaminase family Transglut_C PF00927.22 EMC80807.1 - 4.7e-35 119.9 0.4 1.3e-16 60.6 0.0 2.4 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_core PF01841.19 EMC80807.1 - 2.3e-16 60.2 0.1 4.9e-16 59.2 0.1 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF11 PF01345.18 EMC80807.1 - 0.015 15.6 0.4 1.3 9.4 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF11 DUF2393 PF09624.10 EMC80807.1 - 0.06 13.4 0.7 11 6.0 0.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2393) TssD PF17642.1 EMC80807.1 - 0.13 12.1 0.2 0.34 10.7 0.2 1.7 1 0 0 1 1 1 0 Hemolysin coregulated protein Hcp (TssD) NRN1 PF15056.6 EMC80808.1 - 4e-23 81.3 0.5 4.8e-23 81.1 0.5 1.1 1 0 0 1 1 1 1 Neuritin protein family tRNA-synt_2d PF01409.20 EMC80809.1 - 5.3e-49 166.9 1.8 2.4e-30 105.8 0.1 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 EMC80809.1 - 2.1e-21 76.1 0.0 7.9e-21 74.3 0.0 2.0 2 0 0 2 2 2 1 Ferredoxin-fold anticodon binding domain tRNA-synt_2 PF00152.20 EMC80809.1 - 0.018 14.1 0.2 2.4 7.2 0.1 2.5 3 0 0 3 3 3 0 tRNA synthetases class II (D, K and N) ANKH PF07260.11 EMC80810.1 - 1.5e-200 665.5 4.3 2.3e-200 665.0 4.3 1.2 1 0 0 1 1 1 1 Progressive ankylosis protein (ANKH) UCR_Fe-S_N PF10399.9 EMC80810.1 - 0.83 9.0 0.0 0.83 9.0 0.0 2.7 3 0 0 3 3 3 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Peptidase_C101 PF16218.5 EMC80811.1 - 8.4e-128 425.2 0.5 9.7e-128 425.0 0.5 1.0 1 0 0 1 1 1 1 Peptidase family C101 Peptidase_C65 PF10275.9 EMC80811.1 - 0.0015 18.0 1.7 0.0094 15.4 1.7 2.0 1 1 0 1 1 1 1 Peptidase C65 Otubain FliS PF02561.14 EMC80811.1 - 0.23 11.7 1.8 0.25 11.6 0.2 1.9 2 1 0 2 2 2 0 Flagellar protein FliS PTPRCAP PF15713.5 EMC80812.1 - 0.0033 17.7 25.6 0.0044 17.3 25.6 1.2 1 0 0 1 1 1 1 Protein tyrosine phosphatase receptor type C-associated RNA_pol_3_Rpc31 PF11705.8 EMC80812.1 - 0.0049 17.2 24.7 0.0049 17.2 24.7 2.1 2 0 0 2 2 2 1 DNA-directed RNA polymerase III subunit Rpc31 BUD22 PF09073.10 EMC80812.1 - 0.033 13.6 23.1 0.037 13.4 23.1 1.2 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 EMC80812.1 - 0.041 12.1 27.0 0.049 11.9 27.0 1.1 1 0 0 1 1 1 0 Nop14-like family Paf1 PF03985.13 EMC80812.1 - 0.099 11.6 32.0 0.13 11.3 32.0 1.1 1 0 0 1 1 1 0 Paf1 AFT PF08731.11 EMC80812.1 - 0.11 12.9 2.6 0.15 12.5 2.6 1.3 1 0 0 1 1 1 0 Transcription factor AFT Sec62 PF03839.16 EMC80812.1 - 0.29 10.6 5.4 0.35 10.3 5.4 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 SpoIIP PF07454.11 EMC80812.1 - 0.31 10.5 8.6 0.33 10.4 8.6 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CNDH2_C PF16858.5 EMC80812.1 - 0.31 10.9 12.4 0.39 10.6 12.4 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term PPL5 PF18168.1 EMC80812.1 - 0.32 10.3 8.7 0.35 10.1 8.7 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Tim54 PF11711.8 EMC80812.1 - 0.36 9.6 9.3 0.42 9.3 9.3 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CobT PF06213.12 EMC80812.1 - 0.36 10.2 28.3 0.46 9.8 28.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DDHD PF02862.17 EMC80812.1 - 0.69 10.0 2.9 0.68 10.1 2.9 1.1 1 0 0 1 1 1 0 DDHD domain Connexin PF00029.19 EMC80812.1 - 0.76 9.5 8.3 0.81 9.4 8.3 1.2 1 0 0 1 1 1 0 Connexin DUF913 PF06025.12 EMC80812.1 - 0.93 8.4 7.4 1 8.3 7.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Cwf_Cwc_15 PF04889.12 EMC80812.1 - 1.2 8.8 22.8 1.8 8.2 22.8 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2722 PF10846.8 EMC80812.1 - 1.3 7.9 8.7 1.4 7.8 8.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) NPR3 PF03666.13 EMC80812.1 - 1.3 7.7 14.0 1.5 7.6 14.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 NARP1 PF12569.8 EMC80812.1 - 1.6 7.5 11.3 1.9 7.3 11.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Plasmodium_Vir PF05795.11 EMC80812.1 - 1.7 8.0 8.4 1.9 7.8 8.4 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein GCD14 PF08704.10 EMC80812.1 - 1.8 8.2 4.3 2.2 7.9 4.3 1.1 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit EIIBC-GUT_N PF03612.14 EMC80812.1 - 1.8 8.2 5.7 2.4 7.9 5.7 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Drc1-Sld2 PF11719.8 EMC80812.1 - 2 7.8 18.1 2.6 7.5 18.1 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein Presenilin PF01080.17 EMC80812.1 - 2.1 7.0 10.3 2.2 7.0 10.3 1.0 1 0 0 1 1 1 0 Presenilin V_ATPase_I PF01496.19 EMC80812.1 - 2.2 6.1 9.6 2.6 5.9 9.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cellulose_synt PF03552.14 EMC80812.1 - 3.9 5.8 4.1 4.7 5.6 4.1 1.0 1 0 0 1 1 1 0 Cellulose synthase Saw1 PF11561.8 EMC80812.1 - 4.4 6.8 5.8 5.4 6.5 5.8 1.2 1 0 0 1 1 1 0 Single strand annealing-weakened 1 DDRGK PF09756.9 EMC80812.1 - 5 6.7 30.9 6.6 6.3 30.9 1.2 1 0 0 1 1 1 0 DDRGK domain AIF_C PF14721.6 EMC80812.1 - 6.4 7.1 6.9 9.2 6.6 6.9 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Hid1 PF12722.7 EMC80812.1 - 6.7 4.7 7.9 6.8 4.7 7.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RAB3GAP2_C PF14656.6 EMC80812.1 - 8.4 4.5 9.6 10 4.2 9.6 1.0 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus RRM_1 PF00076.22 EMC80813.1 - 1.5e-16 60.0 0.1 2.3e-16 59.3 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMC80813.1 - 0.061 13.2 0.0 0.12 12.3 0.0 1.5 1 1 0 1 1 1 0 Occluded RNA-recognition motif Glyco_transf_22 PF03901.17 EMC80814.1 - 1.3e-51 176.2 26.6 1.8e-51 175.7 26.6 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Transferrin PF00405.17 EMC80815.1 - 1.6e-223 740.8 11.4 1.7e-119 398.9 1.2 2.0 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.7 EMC80815.1 - 9e-14 51.6 0.0 1.7e-05 24.5 0.0 3.1 2 2 0 2 2 2 2 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.20 EMC80815.1 - 0.0005 19.6 0.2 0.69 9.3 0.1 2.7 2 1 1 3 3 3 2 Bacterial extracellular solute-binding proteins, family 3 DUF3421 PF11901.8 EMC80815.1 - 0.0082 16.1 0.0 0.8 9.7 0.0 2.9 2 1 0 2 2 2 1 Protein of unknown function (DUF3421) Jiv90 PF14901.6 EMC80815.1 - 0.015 15.4 0.4 8.3 6.6 0.0 3.5 3 0 0 3 3 3 0 Cleavage inducing molecular chaperone IL12p40_C PF10420.9 EMC80815.1 - 0.13 12.8 7.4 5.1 7.7 0.8 2.8 2 0 0 2 2 2 0 Cytokine interleukin-12p40 C-terminus PDZ PF00595.24 EMC80816.1 - 1.1e-63 211.6 9.0 1.7e-20 73.1 0.2 3.5 3 0 0 3 3 3 3 PDZ domain Guanylate_kin PF00625.21 EMC80816.1 - 1.2e-58 197.8 0.2 2.1e-58 197.0 0.2 1.4 1 0 0 1 1 1 1 Guanylate kinase MAGUK_N_PEST PF10608.9 EMC80816.1 - 2.3e-58 195.7 10.8 6.1e-58 194.4 10.8 1.8 1 0 0 1 1 1 1 Polyubiquitination (PEST) N-terminal domain of MAGUK PDZ_6 PF17820.1 EMC80816.1 - 4.9e-30 103.2 2.7 7.2e-11 41.8 0.1 3.6 3 0 0 3 3 3 3 PDZ domain PDZ_assoc PF10600.9 EMC80816.1 - 6.3e-28 97.4 5.0 6.3e-28 97.4 5.0 2.9 2 1 0 2 2 2 1 PDZ-associated domain of NMDA receptors PDZ_2 PF13180.6 EMC80816.1 - 3.2e-18 65.8 2.2 3.5e-05 24.0 0.0 3.9 4 0 0 4 4 4 3 PDZ domain SH3_1 PF00018.28 EMC80816.1 - 3.2e-08 33.0 0.1 9.1e-08 31.6 0.1 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC80816.1 - 4.4e-08 32.7 0.0 1.2e-07 31.3 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain L27_1 PF09058.10 EMC80816.1 - 0.0023 17.9 0.3 0.0065 16.4 0.3 1.8 1 0 0 1 1 1 1 L27_1 SH3_9 PF14604.6 EMC80816.1 - 0.043 13.7 0.0 0.15 12.0 0.0 2.0 1 0 0 1 1 1 0 Variant SH3 domain adh_short PF00106.25 EMC80817.1 - 1.4e-42 145.4 0.0 1.8e-42 145.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC80817.1 - 2.1e-26 92.9 0.0 3e-26 92.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC80817.1 - 4.5e-08 33.2 0.0 6.7e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EMC80817.1 - 1.7e-06 27.7 0.0 6.8e-06 25.7 0.0 1.7 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) Eno-Rase_NADH_b PF12242.8 EMC80817.1 - 0.17 11.7 0.1 0.37 10.6 0.1 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase adh_short PF00106.25 EMC80818.1 - 4.2e-35 121.0 0.0 5.5e-35 120.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC80818.1 - 2e-24 86.5 0.0 2.5e-24 86.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC80818.1 - 0.00032 20.7 0.0 0.00047 20.1 0.0 1.2 1 0 0 1 1 1 1 KR domain Lipocalin_2 PF08212.12 EMC80819.1 - 2.3e-23 82.8 0.0 3.4e-23 82.2 0.0 1.3 1 1 0 1 1 1 1 Lipocalin-like domain Lipocalin PF00061.23 EMC80819.1 - 6.4e-23 81.5 0.1 7.4e-23 81.4 0.1 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family VDE PF07137.11 EMC80819.1 - 1.8e-06 27.7 0.0 2.3e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 VDE lipocalin domain Triabin PF03973.13 EMC80819.1 - 0.00012 22.0 0.3 0.00037 20.4 0.3 1.8 1 1 0 1 1 1 1 Triabin HeH PF12949.7 EMC80819.1 - 0.12 12.1 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 HeH/LEM domain IPP-2 PF04979.14 EMC80820.1 - 4e-39 134.4 15.9 4e-39 134.4 15.9 1.3 1 1 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) DUF3435 PF11917.8 EMC80820.1 - 0.068 12.1 5.3 0.08 11.9 5.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) CDC27 PF09507.10 EMC80820.1 - 0.1 12.0 18.7 0.13 11.7 18.7 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 BAR_3 PF16746.5 EMC80821.1 - 4.5e-81 272.1 14.4 7.7e-81 271.3 14.4 1.4 1 0 0 1 1 1 1 BAR domain of APPL family ArfGap PF01412.18 EMC80821.1 - 2.5e-40 137.2 0.1 2.5e-40 137.2 0.1 2.6 4 0 0 4 4 4 1 Putative GTPase activating protein for Arf Ank_2 PF12796.7 EMC80821.1 - 4.9e-15 55.9 0.9 1.3e-08 35.3 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) PH PF00169.29 EMC80821.1 - 1.4e-14 54.5 0.6 1.4e-14 54.5 0.6 2.0 2 0 0 2 2 2 1 PH domain Ank_5 PF13857.6 EMC80821.1 - 1e-09 38.4 0.5 2.1e-06 27.9 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EMC80821.1 - 4.1e-07 30.2 0.3 0.062 13.8 0.0 4.4 4 0 0 4 4 4 1 Ankyrin repeat Ank_3 PF13606.6 EMC80821.1 - 4.1e-06 26.7 0.1 0.03 14.9 0.0 3.9 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EMC80821.1 - 0.00011 22.6 0.0 0.023 15.3 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) PH_8 PF15409.6 EMC80821.1 - 0.069 13.4 0.2 0.24 11.7 0.2 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain PH_11 PF15413.6 EMC80821.1 - 0.19 12.1 8.3 0.45 11.0 3.3 3.0 2 1 0 2 2 2 0 Pleckstrin homology domain APG6_N PF17675.1 EMC80821.1 - 6.4 7.3 12.1 3.1 8.3 6.4 2.9 2 0 0 2 2 2 0 Apg6 coiled-coil region PID_2 PF14719.6 EMC80822.1 - 3.6e-64 216.0 0.9 4.4e-64 215.7 0.9 1.1 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PID PF00640.23 EMC80822.1 - 7.4e-05 22.8 0.0 0.00011 22.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) CP_ATPgrasp_2 PF14403.6 EMC80822.1 - 0.12 11.3 0.1 0.16 10.9 0.1 1.1 1 0 0 1 1 1 0 Circularly permuted ATP-grasp type 2 MMR_HSR1 PF01926.23 EMC80823.1 - 5.7e-15 55.4 0.1 3.1e-13 49.8 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC80823.1 - 5.8e-08 32.8 0.1 0.013 15.4 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 EMC80823.1 - 2.4e-06 27.2 0.1 0.00051 19.6 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B AIG1 PF04548.16 EMC80823.1 - 0.00084 18.7 0.0 0.0022 17.3 0.0 1.8 1 0 0 1 1 1 1 AIG1 family cobW PF02492.19 EMC80823.1 - 0.022 14.4 0.3 0.19 11.3 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 EMC80823.1 - 0.7 10.2 4.2 3.1 8.2 0.0 3.2 2 1 0 2 2 2 0 AAA ATPase domain BUD22 PF09073.10 EMC80823.1 - 1.8 7.8 13.2 1.4 8.2 8.6 2.2 2 0 0 2 2 2 0 BUD22 Dynamin_N PF00350.23 EMC80823.1 - 4.3 7.4 8.5 2.4 8.2 0.3 3.4 3 1 1 4 4 4 0 Dynamin family P5-ATPase PF12409.8 EMC80824.1 - 7.9e-38 129.4 0.3 1.9e-37 128.1 0.3 1.7 1 0 0 1 1 1 1 P5-type ATPase cation transporter E1-E2_ATPase PF00122.20 EMC80824.1 - 7.8e-37 126.5 0.2 7.8e-37 126.5 0.2 1.6 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EMC80824.1 - 2.1e-12 47.8 0.1 3e-11 44.0 0.1 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EMC80824.1 - 3.9e-07 30.1 0.0 8.2e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EMC80824.1 - 2.8e-06 26.9 0.0 6.7e-06 25.7 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus FapA PF03961.13 EMC80824.1 - 0.017 13.8 0.0 0.026 13.1 0.0 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Ets PF00178.22 EMC80825.1 - 1e-33 115.6 3.8 3.5e-33 113.9 0.6 2.4 2 0 0 2 2 2 1 Ets-domain SAM_PNT PF02198.16 EMC80825.1 - 5.6e-25 87.1 3.3 8e-25 86.6 2.4 1.8 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain Acetyltransf_2 PF00797.17 EMC80825.1 - 0.024 14.4 0.2 0.13 12.0 0.1 2.1 1 1 0 1 1 1 0 N-acetyltransferase Aldolase_II PF00596.21 EMC80826.1 - 8.4e-48 162.8 0.0 9.9e-48 162.5 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Syja_N PF02383.18 EMC80826.1 - 0.077 12.3 0.0 0.098 12.0 0.0 1.1 1 0 0 1 1 1 0 SacI homology domain 2-oxoacid_dh PF00198.23 EMC80827.1 - 4.6e-74 248.8 0.4 6.5e-74 248.3 0.4 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EMC80827.1 - 6.7e-21 73.9 0.2 1.6e-20 72.7 0.2 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EMC80827.1 - 1.1e-09 38.4 0.0 3.4e-09 36.9 0.0 1.9 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 EMC80827.1 - 0.00016 21.4 0.0 0.014 15.2 0.0 2.9 1 1 1 2 2 2 1 Biotin-lipoyl like CIDE-N PF02017.15 EMC80827.1 - 0.11 12.6 0.5 0.33 11.0 0.1 2.0 2 0 0 2 2 2 0 CIDE-N domain Xlink PF00193.17 EMC80828.1 - 2.4e-20 72.7 0.5 5.5e-20 71.5 0.0 1.8 2 0 0 2 2 2 1 Extracellular link domain DUF5527 PF17665.1 EMC80828.1 - 0.014 14.9 0.1 0.027 14.0 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5527) PBP-Tp47_a PF14889.6 EMC80828.1 - 0.076 12.7 0.1 0.57 9.8 0.0 2.2 2 0 0 2 2 2 0 Penicillin-binding protein Tp47 domain a SDF PF00375.18 EMC80829.1 - 3.7e-133 444.3 27.6 4.4e-133 444.1 27.6 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family Trypsin PF00089.26 EMC80830.1 - 5.2e-36 124.5 0.0 7.3e-36 124.0 0.0 1.2 1 0 0 1 1 1 1 Trypsin CUB PF00431.20 EMC80830.1 - 3.3e-24 85.3 0.0 7.9e-24 84.1 0.0 1.7 1 0 0 1 1 1 1 CUB domain Sushi PF00084.20 EMC80830.1 - 1.9e-14 54.0 11.0 4.4e-08 33.6 0.2 3.4 4 0 0 4 4 4 2 Sushi repeat (SCR repeat) EGF PF00008.27 EMC80830.1 - 3.8e-08 33.5 3.4 3.8e-08 33.5 3.4 3.8 4 0 0 4 4 4 1 EGF-like domain hEGF PF12661.7 EMC80830.1 - 0.00032 21.2 0.4 0.00032 21.2 0.4 4.2 2 0 0 2 2 2 1 Human growth factor-like EGF DUF1986 PF09342.11 EMC80830.1 - 0.00044 20.6 1.0 0.0015 18.9 1.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) RVT_1 PF00078.27 EMC80831.1 - 0.0083 15.7 0.0 0.015 14.9 0.0 1.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) COMM_domain PF07258.14 EMC80832.1 - 3e-24 84.9 0.0 6.6e-24 83.8 0.0 1.6 1 0 0 1 1 1 1 COMM domain HbrB PF08539.11 EMC80833.1 - 5.5e-10 39.5 0.5 2.5e-07 30.9 0.1 2.5 1 1 1 2 2 2 2 HbrB-like zf-TRAF PF02176.18 EMC80834.1 - 2.1e-21 76.4 33.9 3e-18 66.3 3.2 3.9 3 1 1 4 4 3 3 TRAF-type zinc finger TRAF6_Z2 PF18048.1 EMC80834.1 - 8.1e-18 64.2 6.0 8.1e-18 64.2 6.0 5.0 6 0 0 6 6 4 1 TNF receptor-associated factor 6 zinc finger 2 zf-C3HC4_2 PF13923.6 EMC80834.1 - 1.7e-09 37.3 5.3 1.7e-09 37.3 5.3 3.9 2 1 2 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC80834.1 - 1.9e-08 34.0 4.9 1.9e-08 34.0 4.9 4.2 3 1 1 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMC80834.1 - 2e-07 30.7 4.2 2e-07 30.7 4.2 3.7 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC80834.1 - 4.1e-07 30.2 4.3 4.1e-07 30.2 4.3 3.8 2 1 1 3 3 2 1 Ring finger domain zf-RING_UBOX PF13445.6 EMC80834.1 - 2.3e-06 27.5 6.1 2.3e-06 27.5 6.1 2.9 3 1 0 3 3 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EMC80834.1 - 4.6e-06 26.7 3.9 4.6e-06 26.7 3.9 3.8 2 1 2 4 4 3 1 zinc finger of C3HC4-type, RING zf-TRAF_2 PF15965.5 EMC80834.1 - 2.2e-05 24.8 7.9 2.2e-05 24.8 7.9 3.8 3 2 2 5 5 3 2 TRAF-like zinc-finger SlyX PF04102.12 EMC80834.1 - 0.00016 22.3 2.6 0.00016 22.3 2.6 2.1 2 0 0 2 2 1 1 SlyX zf-RING_5 PF14634.6 EMC80834.1 - 0.00029 20.7 4.0 0.00029 20.7 4.0 4.1 2 1 1 3 3 1 1 zinc-RING finger domain PspA_IM30 PF04012.12 EMC80834.1 - 0.00079 19.1 0.9 0.0022 17.6 0.9 1.8 1 0 0 1 1 1 1 PspA/IM30 family Med21 PF11221.8 EMC80834.1 - 0.001 19.3 2.4 0.0023 18.2 2.4 1.6 1 1 0 1 1 1 1 Subunit 21 of Mediator complex UPF0242 PF06785.11 EMC80834.1 - 0.0057 16.8 1.3 0.013 15.7 1.3 1.5 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Prok-RING_4 PF14447.6 EMC80834.1 - 0.007 16.2 4.4 0.007 16.2 4.4 3.8 2 2 1 3 3 2 1 Prokaryotic RING finger family 4 Tropomyosin_1 PF12718.7 EMC80834.1 - 0.0083 16.3 1.1 0.015 15.4 1.1 1.3 1 0 0 1 1 1 1 Tropomyosin like TSC22 PF01166.18 EMC80834.1 - 0.0086 16.4 2.0 3.6 8.0 0.1 3.1 1 1 2 3 3 3 1 TSC-22/dip/bun family CENP-F_leu_zip PF10473.9 EMC80834.1 - 0.017 15.2 0.7 0.044 13.8 0.7 1.6 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 zf-RING_11 PF17123.5 EMC80834.1 - 0.021 14.6 2.9 0.077 12.8 2.9 2.1 1 0 0 1 1 1 0 RING-like zinc finger HMMR_N PF15905.5 EMC80834.1 - 0.023 14.2 0.4 0.039 13.4 0.4 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF1664 PF07889.12 EMC80834.1 - 0.024 14.7 0.9 0.055 13.5 0.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 EMC80834.1 - 0.024 13.5 0.2 0.042 12.7 0.2 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF2730 PF10805.8 EMC80834.1 - 0.027 14.5 0.1 0.065 13.3 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) Spc29 PF17082.5 EMC80834.1 - 0.038 13.8 0.1 0.078 12.8 0.1 1.5 1 0 0 1 1 1 0 Spindle Pole Component 29 Sina PF03145.16 EMC80834.1 - 0.05 13.5 26.2 0.1 12.6 6.4 4.0 2 1 2 4 4 4 0 Seven in absentia protein family zf-RAG1 PF10426.9 EMC80834.1 - 0.059 13.5 0.8 0.33 11.1 0.1 2.8 2 0 0 2 2 1 0 Recombination-activating protein 1 zinc-finger domain DUF16 PF01519.16 EMC80834.1 - 0.06 13.8 2.3 0.14 12.7 1.5 2.0 2 0 0 2 2 1 0 Protein of unknown function DUF16 U-box PF04564.15 EMC80834.1 - 0.061 13.5 0.1 0.25 11.5 0.0 2.1 2 0 0 2 2 1 0 U-box domain Myosin_tail_1 PF01576.19 EMC80834.1 - 0.11 10.3 1.3 0.15 9.8 1.3 1.1 1 0 0 1 1 1 0 Myosin tail Tropomyosin PF00261.20 EMC80834.1 - 0.14 11.5 2.2 0.23 10.8 2.2 1.2 1 0 0 1 1 1 0 Tropomyosin TMF_DNA_bd PF12329.8 EMC80834.1 - 0.3 11.1 2.2 0.56 10.2 2.2 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding zf-C2H2_4 PF13894.6 EMC80834.1 - 0.43 11.6 0.2 0.43 11.6 0.2 6.2 6 0 0 6 6 5 0 C2H2-type zinc finger Cortex-I_coil PF09304.10 EMC80834.1 - 1.2 9.4 4.7 0.54 10.5 0.9 2.3 3 0 0 3 3 2 0 Cortexillin I, coiled coil DM PF00751.18 EMC80834.1 - 1.4 8.9 17.3 2.6 8.0 4.1 3.3 1 1 2 3 3 3 0 DM DNA binding domain TACC_C PF05010.14 EMC80834.1 - 1.7 8.4 7.8 0.066 13.0 1.5 1.7 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal RAG1 PF12940.7 EMC80835.1 - 0 1249.1 1.2 0 1248.6 1.2 1.1 1 0 0 1 1 1 1 Recombination-activation protein 1 (RAG1), recombinase RAG1_imp_bd PF12560.8 EMC80835.1 - 6.8e-111 370.4 16.4 6.8e-111 370.4 16.4 2.2 2 0 0 2 2 2 1 RAG1 importin binding zf-RAG1 PF10426.9 EMC80835.1 - 5.7e-18 64.7 10.5 9.9e-17 60.8 2.4 2.7 2 0 0 2 2 2 2 Recombination-activating protein 1 zinc-finger domain zf-C3HC4 PF00097.25 EMC80835.1 - 6.3e-07 29.2 14.6 6.3e-07 29.2 14.6 3.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC80835.1 - 0.00012 21.8 13.7 0.00012 21.8 13.7 3.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EMC80835.1 - 0.00025 20.8 8.7 0.00025 20.8 8.7 2.5 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 EMC80835.1 - 0.013 15.7 13.4 0.013 15.7 13.4 3.1 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EMC80835.1 - 0.53 10.4 18.1 0.083 12.9 13.2 2.3 2 0 0 2 2 2 0 RING-type zinc-finger RAG2 PF03089.14 EMC80836.1 - 3.4e-186 618.1 0.0 4.4e-186 617.7 0.0 1.1 1 0 0 1 1 1 1 Recombination activating protein 2 RAG2_PHD PF13341.6 EMC80836.1 - 8.1e-47 157.2 2.6 1.7e-46 156.2 2.6 1.6 1 0 0 1 1 1 1 RAG2 PHD domain Kelch_3 PF13415.6 EMC80836.1 - 5.3e-10 39.3 0.0 2.4e-05 24.5 0.0 3.7 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_4 PF13418.6 EMC80836.1 - 4.8e-05 23.3 1.8 4.1 7.5 0.0 5.0 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC80836.1 - 0.00014 21.7 0.2 0.57 10.2 0.0 4.0 4 0 0 4 4 4 1 Kelch motif PHD PF00628.29 EMC80836.1 - 0.0081 16.0 1.8 0.015 15.1 0.2 2.3 2 0 0 2 2 2 1 PHD-finger CAF1C_H4-bd PF12265.8 EMC80836.1 - 0.088 13.1 0.0 1.1 9.5 0.0 2.5 2 0 0 2 2 2 0 Histone-binding protein RBBP4 or subunit C of CAF1 complex TLV_coat PF00429.19 EMC80838.1 - 2.6e-109 366.5 0.7 3.1e-109 366.2 0.7 1.0 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) Lipoprotein_20 PF13942.6 EMC80838.1 - 0.14 12.1 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 YfhG lipoprotein LRR_8 PF13855.6 EMC80839.1 - 1.7e-46 155.8 51.6 3.2e-14 52.4 2.8 5.3 2 2 4 6 6 6 6 Leucine rich repeat LRR_5 PF13306.6 EMC80839.1 - 2.3e-22 79.3 0.0 2.2e-14 53.5 0.1 2.7 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 EMC80839.1 - 1.4e-20 73.0 26.5 3.4e-07 30.5 1.1 6.1 2 2 2 6 6 6 5 Leucine Rich repeats (2 copies) I-set PF07679.16 EMC80839.1 - 6.2e-14 51.8 0.0 1.3e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC80839.1 - 3.2e-11 43.2 2.7 3.7e-11 43.1 0.1 2.4 3 0 0 3 3 3 1 Immunoglobulin domain Ig_3 PF13927.6 EMC80839.1 - 4.8e-11 43.1 1.2 3.1e-10 40.5 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin domain LRR_9 PF14580.6 EMC80839.1 - 3.9e-08 33.0 9.1 9.1e-07 28.5 0.5 2.9 1 1 2 3 3 3 3 Leucine-rich repeat V-set PF07686.17 EMC80839.1 - 2.3e-07 31.0 0.9 1.9e-05 24.8 0.9 2.5 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.6 EMC80839.1 - 2.5e-06 27.7 1.3 3.8e-06 27.2 0.1 1.9 2 0 0 2 2 1 1 Immunoglobulin domain LRR_1 PF00560.33 EMC80839.1 - 9.7e-05 22.4 31.5 0.54 11.0 0.0 9.1 8 1 1 9 9 9 2 Leucine Rich Repeat Ig_6 PF18452.1 EMC80839.1 - 0.00031 20.2 0.4 0.001 18.6 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain LRR_6 PF13516.6 EMC80839.1 - 0.066 13.3 24.8 2.2 8.5 0.3 7.3 7 0 0 7 7 7 0 Leucine Rich repeat Insulin_TMD PF17870.1 EMC80839.1 - 0.12 12.4 0.7 0.31 11.1 0.7 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Podoplanin PF05808.11 EMC80839.1 - 0.25 11.4 7.7 0.47 10.5 7.3 1.6 1 1 0 1 1 1 0 Podoplanin LRRNT PF01462.18 EMC80839.1 - 6.7 6.5 12.6 0.044 13.4 3.0 2.5 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain API5 PF05918.11 EMC80840.1 - 7.9e-197 655.2 0.0 9.4e-197 654.9 0.0 1.0 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) HEAT_2 PF13646.6 EMC80840.1 - 9.2e-05 22.8 0.1 0.00036 20.9 0.1 1.9 2 0 0 2 2 2 1 HEAT repeats MMS19_N PF14500.6 EMC80840.1 - 0.018 14.6 2.3 0.13 11.8 2.3 2.2 1 1 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II Dak2 PF02734.17 EMC80840.1 - 0.024 14.5 0.0 0.075 12.9 0.0 1.7 1 1 0 1 1 1 0 DAK2 domain adh_short PF00106.25 EMC80841.1 - 1.5e-32 112.6 0.4 2.7e-20 72.6 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMC80841.1 - 8e-17 61.6 0.2 3.3e-10 39.9 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC80841.1 - 2.2e-06 27.7 0.0 0.0019 18.2 0.0 2.1 2 0 0 2 2 2 2 KR domain NAD_binding_10 PF13460.6 EMC80841.1 - 0.0032 17.4 0.1 0.0047 16.8 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EMC80841.1 - 0.011 15.3 0.1 0.4 10.1 0.0 2.1 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EMC80841.1 - 0.032 14.5 0.0 0.067 13.4 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Adenylsucc_synt PF00709.21 EMC80841.1 - 0.061 12.2 0.0 0.087 11.7 0.0 1.2 1 0 0 1 1 1 0 Adenylosuccinate synthetase 2OG-FeII_Oxy_2 PF13532.6 EMC80842.1 - 3.7e-32 112.1 0.1 4.4e-32 111.9 0.1 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Aminotran_1_2 PF00155.21 EMC80843.1 - 3.7e-59 200.7 0.0 6.9e-59 199.8 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EMC80843.1 - 0.012 14.9 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase Glyco_transf_64 PF09258.10 EMC80844.1 - 1.1e-98 329.5 0.2 1.5e-98 328.9 0.2 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Exostosin PF03016.15 EMC80844.1 - 1.6e-56 191.8 0.0 2.1e-56 191.3 0.0 1.2 1 0 0 1 1 1 1 Exostosin family Tetraspanin PF00335.20 EMC80845.1 - 1e-50 172.6 9.1 1.2e-50 172.4 9.1 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF2981 PF11200.8 EMC80845.1 - 0.002 18.0 2.9 0.0058 16.4 2.4 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF2981) GATase_5 PF13507.6 EMC80845.1 - 0.018 14.1 0.0 0.025 13.7 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain DUF3243 PF11588.8 EMC80845.1 - 0.16 12.3 0.0 0.27 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3243) Tetraspanin PF00335.20 EMC80846.1 - 1.1e-48 165.9 11.1 1.3e-48 165.7 11.1 1.0 1 0 0 1 1 1 1 Tetraspanin family p53-inducible11 PF14936.6 EMC80847.1 - 5.6e-90 300.3 1.5 6.3e-90 300.1 1.5 1.0 1 0 0 1 1 1 1 Tumour protein p53-inducible protein 11 DUF4345 PF14248.6 EMC80847.1 - 0.00011 22.0 0.7 0.00011 22.0 0.7 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF4345) DUF3325 PF11804.8 EMC80847.1 - 0.025 14.7 1.2 0.083 13.0 1.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3325) DUF2647 PF10839.8 EMC80847.1 - 0.14 12.2 0.1 0.31 11.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2647) SET PF00856.28 EMC80848.1 - 2.3e-05 24.9 0.6 0.00016 22.1 0.0 2.2 2 0 0 2 2 2 1 SET domain zf_PR_Knuckle PF18445.1 EMC80848.1 - 0.0001 22.1 1.7 0.00023 20.9 1.7 1.6 1 0 0 1 1 1 1 PR zinc knuckle motif GFA PF04828.14 EMC80848.1 - 0.1 13.0 0.0 30 5.0 0.0 2.7 2 0 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme C2 PF00168.30 EMC80851.1 - 7.9e-24 83.9 0.0 8.7e-14 51.7 0.1 2.3 2 0 0 2 2 2 2 C2 domain PI3K_C2 PF00792.24 EMC80851.1 - 2.6e-05 24.2 0.1 0.066 13.1 0.0 3.0 2 1 1 3 3 3 2 Phosphoinositide 3-kinase C2 2OG-FeII_Oxy_4 PF13661.6 EMC80851.1 - 0.016 15.9 0.1 0.043 14.5 0.1 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily LRR_8 PF13855.6 EMC80853.1 - 3.1e-50 167.8 49.9 3.3e-12 46.0 5.2 6.9 2 2 5 7 7 7 7 Leucine rich repeat LRR_5 PF13306.6 EMC80853.1 - 2.3e-15 56.7 0.0 7.1e-07 29.2 0.1 2.5 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 EMC80853.1 - 3.1e-14 52.9 44.7 0.011 16.2 2.5 9.1 3 2 7 11 11 11 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC80853.1 - 5.9e-07 29.1 15.8 0.009 15.5 0.4 4.3 2 2 2 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 EMC80853.1 - 3.9e-05 23.6 31.4 8 7.5 0.7 10.6 11 1 0 11 11 11 2 Leucine Rich Repeat LRRNT PF01462.18 EMC80853.1 - 0.78 9.5 17.0 0.037 13.7 3.1 3.1 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain Actin PF00022.19 EMC80854.1 - 7.9e-79 265.2 0.0 1.3e-77 261.1 0.0 1.9 1 1 0 1 1 1 1 Actin EcoRII-C PF09019.11 EMC80854.1 - 0.12 12.5 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 EcoRII C terminal Chorein_N PF12624.7 EMC80855.1 - 4.1e-17 62.4 0.1 2.1e-15 56.8 0.0 3.4 3 0 0 3 3 3 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 EMC80855.1 - 0.02 14.7 5.3 0.021 14.7 2.2 2.5 2 1 0 2 2 2 0 Vacuolar sorting-associated protein 13, N-terminal DUF3381 PF11861.8 EMC80855.1 - 0.75 9.6 5.9 0.097 12.5 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Ank_2 PF12796.7 EMC80856.1 - 3.3e-37 126.9 4.0 4.5e-12 46.4 0.1 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC80856.1 - 4.6e-37 125.6 7.8 1.2e-07 31.9 0.2 6.5 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC80856.1 - 3.7e-32 110.3 2.6 1.2e-07 32.2 0.1 5.1 4 1 1 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 EMC80856.1 - 8.6e-32 108.2 6.1 8.6e-05 22.8 0.1 7.2 7 0 0 7 7 7 6 Ankyrin repeat Ank_3 PF13606.6 EMC80856.1 - 1.1e-31 105.3 1.3 5.3e-05 23.3 0.0 6.9 6 0 0 6 6 6 6 Ankyrin repeat SAM_1 PF00536.30 EMC80856.1 - 2.1e-26 92.2 0.0 3e-15 56.4 0.0 2.8 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC80856.1 - 1.1e-22 79.9 0.3 1e-14 54.3 0.1 2.7 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) WD40 PF00400.32 EMC80857.1 - 8.8e-64 209.9 35.4 5.1e-09 36.6 0.5 13.3 13 0 0 13 13 13 10 WD domain, G-beta repeat NB-ARC PF00931.22 EMC80857.1 - 2.1e-57 194.2 0.0 4e-57 193.3 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain APAF1_C PF17908.1 EMC80857.1 - 9.5e-56 187.5 0.7 2.6e-55 186.1 0.7 1.8 1 0 0 1 1 1 1 APAF-1 helical domain ANAPC4_WD40 PF12894.7 EMC80857.1 - 5.9e-25 87.4 9.3 0.00045 20.5 0.0 9.2 2 1 6 8 8 8 7 Anaphase-promoting complex subunit 4 WD40 domain CARD PF00619.21 EMC80857.1 - 1e-18 67.1 1.5 3.7e-18 65.3 1.5 2.1 1 0 0 1 1 1 1 Caspase recruitment domain eIF2A PF08662.11 EMC80857.1 - 1.9e-11 44.2 7.9 8.8e-05 22.5 0.1 5.3 2 2 1 4 4 4 1 Eukaryotic translation initiation factor eIF2A CARD_2 PF16739.5 EMC80857.1 - 3.6e-10 39.7 0.6 1.1e-09 38.1 0.6 1.9 1 0 0 1 1 1 1 Caspase recruitment domain Ge1_WD40 PF16529.5 EMC80857.1 - 1.1e-09 37.7 10.8 0.0041 16.1 3.2 7.1 5 2 2 8 8 8 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EMC80857.1 - 2e-08 33.9 3.4 0.17 11.2 0.0 6.3 4 2 2 6 6 6 3 WD40-like domain Nup160 PF11715.8 EMC80857.1 - 0.00012 20.9 12.2 0.58 8.7 0.0 5.9 4 2 3 7 7 7 2 Nucleoporin Nup120/160 AAA_16 PF13191.6 EMC80857.1 - 0.001 19.5 0.0 0.0021 18.4 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain DUF2415 PF10313.9 EMC80857.1 - 0.017 15.1 0.1 0.25 11.3 0.0 3.1 3 0 0 3 3 3 0 Uncharacterised protein domain (DUF2415) AAA_22 PF13401.6 EMC80857.1 - 0.021 15.1 0.1 0.16 12.3 0.0 2.5 3 0 0 3 3 2 0 AAA domain PD40 PF07676.12 EMC80857.1 - 0.14 12.2 2.5 35 4.5 0.1 4.4 6 0 0 6 6 5 0 WD40-like Beta Propeller Repeat DUF2304 PF10066.9 EMC80858.1 - 0.00048 20.3 0.1 0.0055 16.9 0.0 2.5 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2304) Sec8_exocyst PF04048.14 EMC80858.1 - 0.015 15.2 0.6 0.015 15.2 0.6 3.2 2 1 1 3 3 3 0 Sec8 exocyst complex component specific domain Helo_like_N PF17111.5 EMC80858.1 - 0.023 14.0 1.3 0.023 14.0 1.3 3.7 2 1 0 3 3 3 0 Fungal N-terminal domain of STAND proteins Snapin_Pallidin PF14712.6 EMC80858.1 - 0.054 13.9 19.5 0.076 13.4 1.1 4.7 3 1 1 4 4 4 0 Snapin/Pallidin COG5 PF10392.9 EMC80858.1 - 0.055 13.6 14.8 1.1 9.5 2.3 4.0 1 1 4 5 5 5 0 Golgi transport complex subunit 5 MHC2-interact PF09307.10 EMC80858.1 - 0.062 13.3 0.0 0.27 11.3 0.0 2.1 1 0 0 1 1 1 0 CLIP, MHC2 interacting MIG-14_Wnt-bd PF06664.12 EMC80858.1 - 0.073 12.3 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 Wnt-binding factor required for Wnt secretion BLOC1_2 PF10046.9 EMC80858.1 - 0.079 13.3 20.3 0.45 10.8 0.6 4.8 1 1 5 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3130 PF11328.8 EMC80858.1 - 0.096 12.9 2.3 1.9 8.8 0.1 3.0 1 1 1 3 3 3 0 Protein of unknown function (DUF3130 NPV_P10 PF05531.12 EMC80858.1 - 0.1 13.1 18.0 0.74 10.3 1.1 4.7 2 1 3 5 5 5 0 Nucleopolyhedrovirus P10 protein DUF5595 PF18077.1 EMC80858.1 - 0.1 12.7 3.2 6.9 6.8 0.0 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF5595) DUF4446 PF14584.6 EMC80858.1 - 0.16 12.0 14.5 2.6 8.0 1.1 4.2 2 1 3 5 5 5 0 Protein of unknown function (DUF4446) DUF4795 PF16043.5 EMC80858.1 - 0.7 9.5 21.8 0.34 10.5 15.4 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) ATG16 PF08614.11 EMC80858.1 - 0.73 10.0 18.4 16 5.7 0.1 3.7 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 EMC80858.1 - 1.9 8.6 20.6 0.8 9.8 3.5 4.1 1 1 5 6 6 6 0 Protein of unknown function (DUF1664) Rx_N PF18052.1 EMC80858.1 - 2.4 8.5 15.6 5 7.5 0.4 4.3 3 1 1 4 4 4 0 Rx N-terminal domain Sec34 PF04136.15 EMC80858.1 - 3.1 7.6 23.2 5.3 6.9 1.9 4.9 2 2 3 5 5 5 0 Sec34-like family Mito_carr PF00153.27 EMC80859.1 - 2.5e-45 152.3 8.4 1.2e-18 66.8 0.1 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein LEM PF03020.15 EMC80860.1 - 1.8e-19 69.0 0.3 3.9e-19 67.9 0.3 1.6 1 0 0 1 1 1 1 LEM domain RAMP4 PF06624.12 EMC80860.1 - 0.081 13.0 0.1 0.3 11.2 0.1 1.9 1 0 0 1 1 1 0 Ribosome associated membrane protein RAMP4 Orf78 PF06024.12 EMC80860.1 - 0.13 12.6 0.4 2.6 8.4 0.0 2.4 2 0 0 2 2 2 0 Orf78 (ac78) DUF4486 PF14858.6 EMC80863.1 - 3.8e-265 880.5 8.2 4.6e-265 880.3 8.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4486) Pkinase PF00069.25 EMC80864.1 - 1.5e-72 244.2 0.0 2.8e-72 243.3 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC80864.1 - 5.3e-35 120.9 0.0 1.1e-34 119.9 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EMC80864.1 - 5e-07 29.0 0.1 2.4e-06 26.8 0.1 1.9 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EMC80864.1 - 2.9e-06 26.8 0.0 6.6e-06 25.6 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC80864.1 - 0.00028 20.3 0.3 0.00072 19.0 0.3 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EMC80864.1 - 0.056 12.5 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 EMC80864.1 - 0.07 13.0 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EMC80864.1 - 0.12 11.1 0.2 3 6.5 0.0 2.1 2 0 0 2 2 2 0 Fungal protein kinase Ets PF00178.22 EMC80865.1 - 1.8e-34 118.0 3.0 3.2e-34 117.2 3.0 1.4 1 0 0 1 1 1 1 Ets-domain Translat_reg PF01818.17 EMC80865.1 - 0.037 14.0 0.1 0.1 12.6 0.1 1.7 1 1 0 1 1 1 0 Bacteriophage translational regulator Lyase_aromatic PF00221.19 EMC80866.1 - 2.2e-194 646.4 0.0 2.5e-194 646.2 0.0 1.0 1 0 0 1 1 1 1 Aromatic amino acid lyase Par3_HAL_N_term PF12053.8 EMC80866.1 - 1e-07 32.1 0.0 2.8e-07 30.7 0.0 1.7 1 0 0 1 1 1 1 N-terminal of Par3 and HAL proteins Amidohydro_3 PF07969.11 EMC80867.1 - 1.3e-24 87.5 0.9 1.6e-16 60.9 0.0 2.8 1 1 1 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 EMC80867.1 - 3.9e-22 79.0 1.3 6.1e-21 75.1 1.3 2.2 1 1 0 1 1 1 1 Amidohydrolase family LSM PF01423.22 EMC80868.1 - 2e-05 24.2 0.0 2.5e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 LSM domain UCH PF00443.29 EMC80869.1 - 2.8e-55 187.6 0.0 7.8e-55 186.1 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EMC80869.1 - 5.4e-20 71.5 8.8 5.4e-20 71.5 8.8 3.0 4 0 0 4 4 4 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 EMC80869.1 - 1.1e-15 58.1 0.3 4e-15 56.2 0.3 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MPM1 PF17234.2 EMC80869.1 - 0.0045 17.3 2.4 0.01 16.1 2.4 1.5 1 0 0 1 1 1 1 Mitochondrial peculiar membrane protein 1 ArfGap PF01412.18 EMC80869.1 - 0.16 12.0 4.2 0.47 10.5 3.0 2.4 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf zf-UBP_var PF17807.1 EMC80869.1 - 0.85 9.4 4.9 0.2 11.5 0.6 2.2 2 0 0 2 2 2 0 Variant UBP zinc finger Peptidase_M24 PF00557.24 EMC80870.1 - 2e-46 158.3 0.0 2.7e-46 157.9 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 CDT1_C PF16679.5 EMC80870.1 - 0.15 12.5 0.0 0.61 10.6 0.0 2.0 2 0 0 2 2 2 0 DNA replication factor Cdt1 C-terminal domain Cas_Csa5 PF09702.10 EMC80870.1 - 0.15 12.3 0.0 0.36 11.1 0.0 1.6 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csa5) STI1 PF17830.1 EMC80871.1 - 0.032 14.2 0.0 25 4.9 0.0 3.4 4 0 0 4 4 4 0 STI1 domain PT PF04886.12 EMC80873.1 - 0.00069 19.1 0.4 0.032 13.8 0.0 3.0 2 1 1 3 3 3 2 PT repeat 7tm_1 PF00001.21 EMC80874.1 - 4.6e-23 81.9 2.9 5.3e-23 81.7 2.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC80874.1 - 4.9e-22 79.0 2.9 5.5e-22 78.8 2.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 EMC80874.1 - 2.1e-06 27.3 0.9 2.5e-06 27.1 0.9 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Cornichon PF03311.14 EMC80875.1 - 4.6e-37 127.1 7.1 3.2e-28 98.5 4.1 2.1 2 0 0 2 2 2 2 Cornichon protein Cofilin_ADF PF00241.20 EMC80876.1 - 1.3e-30 105.7 0.1 2.2e-30 104.9 0.1 1.4 1 1 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein GTP_cyclohydroI PF01227.22 EMC80877.1 - 1.1e-63 214.0 0.5 1.2e-63 213.7 0.5 1.0 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 EMC80877.1 - 0.00066 19.8 0.0 0.0014 18.8 0.0 1.5 1 1 0 1 1 1 1 QueF-like protein MAPKK1_Int PF08923.10 EMC80877.1 - 0.038 13.8 0.1 0.047 13.5 0.1 1.2 1 0 0 1 1 1 0 Mitogen-activated protein kinase kinase 1 interacting HMG_box PF00505.19 EMC80878.1 - 5.2e-08 33.2 1.7 7.8e-08 32.6 0.2 2.1 1 1 1 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC80878.1 - 0.00067 20.2 0.2 0.00067 20.2 0.2 2.8 2 1 1 3 3 3 1 HMG-box domain SspP PF08179.12 EMC80878.1 - 0.092 13.2 3.8 9.6 6.7 0.0 2.7 2 0 0 2 2 2 0 Small acid-soluble spore protein P family DUF1764 PF08576.10 EMC80878.1 - 2.5 9.1 12.0 4.8 8.2 1.7 2.3 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Mcl1_mid PF12341.8 EMC80879.1 - 2.5e-97 325.8 0.0 5.5e-97 324.7 0.0 1.6 1 0 0 1 1 1 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 EMC80879.1 - 2.8e-21 75.4 7.7 3e-07 31.0 0.1 6.0 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC80879.1 - 1.6e-10 41.1 0.6 0.00041 20.6 0.1 4.8 2 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC80879.1 - 1.3e-06 28.5 0.0 6.6e-05 22.9 0.0 2.5 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EMC80879.1 - 0.01 14.5 0.1 0.19 10.3 0.0 2.2 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Hira PF07569.11 EMC80879.1 - 0.045 13.5 0.1 12 5.6 0.0 2.5 2 0 0 2 2 2 0 TUP1-like enhancer of split Ge1_WD40 PF16529.5 EMC80879.1 - 0.12 11.3 3.1 6.3 5.7 0.1 3.4 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein SOCS PF12610.8 EMC80880.1 - 2e-19 69.7 3.2 6.8e-19 68.0 3.2 1.9 1 0 0 1 1 1 1 Suppressor of cytokine signalling SOCS_box PF07525.16 EMC80880.1 - 1.2e-10 41.5 0.1 2.4e-10 40.6 0.1 1.5 1 0 0 1 1 1 1 SOCS box SH2 PF00017.24 EMC80880.1 - 2.4e-08 33.9 0.0 7.7e-08 32.3 0.0 2.0 2 0 0 2 2 2 1 SH2 domain MISS PF15822.5 EMC80881.1 - 1.5e-100 335.9 125.2 1.7e-100 335.8 125.2 1.0 1 0 0 1 1 1 1 MAPK-interacting and spindle-stabilising protein-like Gal-bind_lectin PF00337.22 EMC80882.1 - 1.1e-36 125.3 0.0 1.4e-36 124.9 0.0 1.1 1 0 0 1 1 1 1 Galactoside-binding lectin F-box-like PF12937.7 EMC80883.1 - 7.3e-05 22.6 0.0 0.00015 21.6 0.0 1.5 1 0 0 1 1 1 1 F-box-like BTK PF00779.19 EMC80883.1 - 0.00098 18.9 1.2 0.0025 17.6 1.2 1.6 1 0 0 1 1 1 1 BTK motif F-box PF00646.33 EMC80883.1 - 0.011 15.6 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 F-box domain Pkinase_Tyr PF07714.17 EMC80884.1 - 4.1e-63 213.1 0.0 6.8e-63 212.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC80884.1 - 1.3e-55 188.6 0.0 2.3e-55 187.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain SAM_1 PF00536.30 EMC80884.1 - 1.9e-10 41.0 4.8 4.3e-10 39.9 0.4 3.3 4 0 0 4 4 4 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC80884.1 - 4.2e-09 36.4 0.3 1e-08 35.2 0.1 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 EMC80884.1 - 0.0062 16.5 0.2 0.021 14.8 0.2 1.8 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_4 PF18017.1 EMC80884.1 - 0.0098 15.8 0.0 0.037 14.0 0.0 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF3552 PF12072.8 EMC80884.1 - 0.77 9.1 4.1 1.3 8.4 4.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) APG6_N PF17675.1 EMC80884.1 - 1.7 9.2 8.1 0.15 12.6 3.2 1.7 2 0 0 2 2 2 0 Apg6 coiled-coil region RasGEF PF00617.19 EMC80885.1 - 1.5e-52 178.4 2.0 3e-52 177.4 2.0 1.5 1 0 0 1 1 1 1 RasGEF domain cNMP_binding PF00027.29 EMC80885.1 - 3.7e-28 97.4 0.0 4.2e-16 58.8 0.0 3.6 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain DEP PF00610.21 EMC80885.1 - 2.3e-22 78.8 2.3 9.7e-22 76.8 1.2 2.3 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RasGEF_N PF00618.20 EMC80885.1 - 2.6e-12 46.9 0.0 7.7e-12 45.4 0.0 1.9 1 0 0 1 1 1 1 RasGEF N-terminal motif RA PF00788.23 EMC80885.1 - 0.04 14.6 0.0 0.13 12.9 0.0 1.9 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain CCDC53 PF10152.9 EMC80886.1 - 0.015 15.8 1.7 0.024 15.1 1.7 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex SPX PF03105.19 EMC80886.1 - 5.2 6.9 7.8 6.5 6.6 7.8 1.1 1 0 0 1 1 1 0 SPX domain DUF5586 PF17824.1 EMC80887.1 - 5.6e-158 526.3 11.9 6.2e-158 526.1 11.9 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5586) DUF2967 PF11179.8 EMC80888.1 - 0.011 14.0 0.3 0.013 13.7 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) RhoGEF PF00621.20 EMC80888.1 - 0.022 15.0 0.0 0.03 14.5 0.0 1.2 1 0 0 1 1 1 0 RhoGEF domain DUF4655 PF15548.6 EMC80888.1 - 0.074 12.0 0.2 0.093 11.7 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4655) Peptidase_M14 PF00246.24 EMC80889.1 - 1.7e-88 297.2 0.3 2.5e-88 296.6 0.1 1.3 2 0 0 2 2 2 1 Zinc carboxypeptidase Propep_M14 PF02244.16 EMC80889.1 - 1.4e-14 54.3 0.1 3.3e-14 53.0 0.1 1.7 1 0 0 1 1 1 1 Carboxypeptidase activation peptide EF-hand_12 PF17901.1 EMC80889.1 - 0.21 12.1 1.3 0.45 11.0 0.0 2.1 2 1 0 2 2 2 0 EF-hand fold domain Sulfotransfer_1 PF00685.27 EMC80891.1 - 6.7e-86 288.1 0.0 7.6e-86 287.9 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC80891.1 - 5.1e-07 30.3 0.0 0.0015 18.9 0.0 2.2 2 0 0 2 2 2 2 Sulfotransferase family Sulphotransf PF09037.10 EMC80891.1 - 0.06 12.9 0.1 5.7 6.4 0.0 2.4 3 0 0 3 3 3 0 Stf0 sulphotransferase UDPGT PF00201.18 EMC80892.1 - 1.1e-223 743.6 0.0 1.3e-223 743.3 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EMC80892.1 - 1.4e-06 28.4 0.0 2.5e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Pro_3_hydrox_C PF05373.11 EMC80892.1 - 0.017 15.2 0.0 0.039 14.0 0.0 1.5 1 0 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal Glyco_transf_4 PF13439.6 EMC80892.1 - 0.03 14.3 0.1 0.58 10.1 0.1 2.3 1 1 0 1 1 1 0 Glycosyltransferase Family 4 Glyco_transf_28 PF03033.20 EMC80892.1 - 0.051 13.6 0.0 0.18 11.9 0.0 1.8 1 1 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain Glyco_trans_4_4 PF13579.6 EMC80892.1 - 0.076 13.5 0.0 0.2 12.1 0.0 1.7 1 1 0 1 1 1 0 Glycosyl transferase 4-like domain YTH PF04146.15 EMC80893.1 - 2.3e-41 141.5 0.1 2.3e-41 141.5 0.1 3.8 2 2 0 2 2 2 1 YT521-B-like domain Trypsin PF00089.26 EMC80894.1 - 3e-72 243.0 0.5 3.4e-72 242.8 0.5 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 EMC80894.1 - 7.4e-08 32.8 0.1 1.9e-07 31.5 0.1 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 EMC80894.1 - 2.7e-06 28.3 0.0 3.9e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF316 PF03761.15 EMC80894.1 - 0.011 15.3 0.0 0.048 13.2 0.0 1.9 1 1 1 2 2 2 0 Chymotrypsin family Peptidase-S1 Trypsin PF00089.26 EMC80895.1 - 1.3e-51 175.5 0.0 1.6e-51 175.3 0.0 1.0 1 0 0 1 1 1 1 Trypsin ThiF PF00899.21 EMC80896.1 - 2.3e-95 318.6 0.0 4.2e-63 213.0 0.0 2.2 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 EMC80896.1 - 1.2e-81 274.3 1.0 2.1e-81 273.5 1.0 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 EMC80896.1 - 4.1e-25 87.8 0.0 9.3e-25 86.6 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 EMC80896.1 - 4.3e-16 58.9 0.2 2.1e-15 56.7 0.1 2.4 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 four-helix bundle E1_UFD PF09358.10 EMC80896.1 - 1e-13 51.8 0.0 4.3e-13 49.8 0.0 2.2 1 0 0 1 1 1 1 Ubiquitin fold domain Latrophilin PF02354.16 EMC80897.1 - 3e-115 385.3 21.1 9.9e-84 281.6 5.5 2.3 1 1 1 2 2 2 2 Latrophilin Cytoplasmic C-terminal region OLF PF02191.16 EMC80897.1 - 1.3e-85 286.9 4.1 6.9e-85 284.6 5.2 1.6 2 0 0 2 2 2 1 Olfactomedin-like domain 7tm_2 PF00002.24 EMC80897.1 - 3.7e-71 239.3 22.2 5.4e-71 238.7 22.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.5 EMC80897.1 - 1.3e-53 181.5 5.1 2.1e-53 180.9 5.1 1.3 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain GPS PF01825.21 EMC80897.1 - 7.8e-16 58.3 7.3 1.7e-15 57.2 7.3 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif HRM PF02793.22 EMC80897.1 - 1e-06 28.9 0.5 3e-06 27.4 0.5 1.9 1 0 0 1 1 1 1 Hormone receptor domain Dicty_CAR PF05462.11 EMC80897.1 - 0.03 13.5 18.2 0.05 12.7 18.2 1.3 1 0 0 1 1 1 0 Slime mold cyclic AMP receptor Pox_A14 PF05767.12 EMC80897.1 - 3.6 7.8 6.5 3.7 7.8 2.1 2.8 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 Pax2_C PF12403.8 EMC80898.1 - 2.1e-16 60.0 2.0 5.8e-16 58.6 2.0 1.7 1 0 0 1 1 1 1 Paired-box protein 2 C terminal Pkinase PF00069.25 EMC80899.1 - 2.5e-73 246.7 0.0 6.4e-73 245.4 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC80899.1 - 2.4e-40 138.5 0.0 5.1e-40 137.4 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 EMC80899.1 - 2.2e-13 49.7 0.1 5.1e-13 48.6 0.1 1.7 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 EMC80899.1 - 1.3e-07 31.3 0.0 3.2e-07 29.9 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EMC80899.1 - 3e-05 23.5 0.1 5.9e-05 22.5 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EMC80899.1 - 0.00023 20.2 0.6 0.00042 19.4 0.0 1.6 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EMC80899.1 - 0.00064 19.7 0.0 0.024 14.6 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EMC80899.1 - 0.012 15.3 0.0 0.033 13.8 0.0 1.8 1 0 0 1 1 1 0 Choline/ethanolamine kinase NMT PF01233.19 EMC80899.1 - 0.034 14.0 0.0 0.061 13.2 0.0 1.4 1 0 0 1 1 1 0 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain RIO1 PF01163.22 EMC80899.1 - 0.045 13.4 0.1 0.098 12.2 0.1 1.5 1 0 0 1 1 1 0 RIO1 family TLE_N PF03920.15 EMC80900.1 - 1.1e-65 219.6 8.3 1.7e-65 219.0 8.3 1.3 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain WD40 PF00400.32 EMC80900.1 - 1.4e-15 57.4 20.0 0.006 17.4 0.4 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC80900.1 - 1.1e-07 32.1 0.1 0.11 12.9 0.0 4.1 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain HALZ PF02183.18 EMC80900.1 - 0.019 15.2 0.2 0.05 13.8 0.2 1.7 1 0 0 1 1 1 0 Homeobox associated leucine zipper WD40_like PF17005.5 EMC80900.1 - 0.023 14.0 0.0 5.3 6.3 0.0 2.7 2 1 0 2 2 2 0 WD40-like domain Nup160 PF11715.8 EMC80900.1 - 0.15 10.6 0.5 7.9 5.0 0.1 2.2 1 1 1 2 2 2 0 Nucleoporin Nup120/160 G-alpha PF00503.20 EMC80901.1 - 2.8e-108 362.2 1.9 3.2e-108 362.0 1.9 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EMC80901.1 - 4.8e-12 45.7 0.2 2.7e-11 43.2 0.2 2.2 1 1 0 1 1 1 1 ADP-ribosylation factor family Trypsin PF00089.26 EMC80902.1 - 1.1e-37 129.9 0.3 1.3e-37 129.8 0.3 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 EMC80902.1 - 0.028 14.8 0.0 0.039 14.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) 7tm_1 PF00001.21 EMC80903.1 - 4.4e-35 121.3 17.9 4.4e-35 121.3 17.9 1.7 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 EMC80903.1 - 2.7e-06 27.0 7.6 2.7e-06 27.0 7.6 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 EMC80903.1 - 0.00022 20.9 15.3 0.00062 19.5 15.3 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 EMC80903.1 - 0.00024 20.5 15.5 0.00036 20.0 15.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DHHC PF01529.20 EMC80903.1 - 6.2 6.9 16.6 0.055 13.6 4.1 3.0 2 1 1 3 3 3 0 DHHC palmitoyltransferase ATP1G1_PLM_MAT8 PF02038.16 EMC80903.1 - 8.4 5.9 9.0 0.39 10.2 1.6 2.7 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family Peptidase_M28 PF04389.17 EMC80904.1 - 6.6e-13 48.8 0.0 1.2e-12 47.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Nicastrin PF05450.15 EMC80904.1 - 6e-06 25.9 0.0 9.7e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 Nicastrin EST1_DNA_bind PF10373.9 EMC80904.1 - 0.13 11.7 0.1 0.25 10.8 0.1 1.4 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain RRM_1 PF00076.22 EMC80905.1 - 7.3e-38 128.2 0.0 3.5e-17 62.0 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EMC80905.1 - 0.007 16.4 0.0 1.6 8.8 0.0 3.2 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 EMC80905.1 - 0.074 13.3 0.2 18 5.5 0.0 2.5 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter NOP5NT PF08156.13 EMC80905.1 - 0.23 11.9 0.5 53 4.3 0.1 3.1 3 0 0 3 3 3 0 NOP5NT (NUC127) domain adh_short PF00106.25 EMC80906.1 - 1.6e-44 151.8 0.0 1.8e-44 151.6 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC80906.1 - 3.4e-27 95.5 0.0 4.2e-27 95.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC80906.1 - 7.5e-08 32.5 0.0 1e-07 32.1 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EMC80906.1 - 0.00074 19.0 0.1 0.00091 18.7 0.1 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Herpes_UL47 PF03362.13 EMC80906.1 - 0.068 11.9 0.0 0.092 11.5 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL47 protein DUF4118 PF13493.6 EMC80906.1 - 0.11 12.3 3.2 0.25 11.2 0.5 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4118) QIL1 PF15884.5 EMC80907.1 - 1e-24 86.9 0.0 1.3e-24 86.5 0.0 1.1 1 0 0 1 1 1 1 MICOS complex subunit MIC13, QIL1 RRM_1 PF00076.22 EMC80908.1 - 2.5e-13 49.6 0.0 5.8e-13 48.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP PF02037.27 EMC80908.1 - 3.5e-10 39.4 0.9 9.5e-10 38.0 0.9 1.8 1 0 0 1 1 1 1 SAP domain RRM_5 PF13893.6 EMC80908.1 - 2e-07 30.6 0.0 3.9e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 EMC80909.1 - 1.9e-14 53.2 0.0 3.7e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMC80909.1 - 3.4e-07 29.9 0.0 5.8e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ank_2 PF12796.7 EMC80910.1 - 5.4e-22 78.2 1.2 4.5e-12 46.4 0.2 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC80910.1 - 5.8e-19 67.9 2.7 2.4e-09 37.3 0.1 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC80910.1 - 9.1e-15 54.8 0.6 8.5e-11 42.2 0.1 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EMC80910.1 - 3.5e-14 52.5 0.8 7.2e-05 23.1 0.1 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 EMC80910.1 - 1.3e-12 46.7 0.5 0.015 15.8 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat ATG16 PF08614.11 EMC80910.1 - 0.00023 21.5 14.0 0.00023 21.5 14.0 2.4 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) HAP1_N PF04849.13 EMC80910.1 - 0.0089 15.3 8.8 0.0089 15.3 8.8 2.2 2 0 0 2 2 2 1 HAP1 N-terminal conserved region DUF724 PF05266.14 EMC80910.1 - 0.017 15.0 11.6 0.017 15.0 11.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF724) ERM PF00769.19 EMC80910.1 - 0.057 13.2 16.7 0.12 12.2 16.7 1.5 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Fez1 PF06818.15 EMC80910.1 - 0.083 13.3 14.9 0.066 13.7 13.5 1.5 2 0 0 2 2 1 0 Fez1 SidE PF12252.8 EMC80910.1 - 0.09 10.3 1.2 0.13 9.8 1.2 1.1 1 0 0 1 1 1 0 Dot/Icm substrate protein Filament PF00038.21 EMC80910.1 - 0.1 12.2 15.1 0.45 10.0 15.1 1.9 1 1 0 1 1 1 0 Intermediate filament protein FUSC PF04632.12 EMC80910.1 - 0.13 10.8 3.2 0.19 10.2 3.2 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4618 PF15397.6 EMC80910.1 - 0.13 11.6 10.9 0.38 10.1 6.1 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) YabA PF06156.13 EMC80910.1 - 0.17 12.5 9.8 0.65 10.7 4.1 3.1 2 1 1 3 3 3 0 Initiation control protein YabA HOOK PF05622.12 EMC80910.1 - 0.2 9.8 13.7 0.32 9.1 13.7 1.3 1 0 0 1 1 1 0 HOOK protein CBP4 PF07960.11 EMC80910.1 - 0.2 11.5 0.1 0.2 11.5 0.1 2.8 2 1 0 2 2 1 0 CBP4 AAA_13 PF13166.6 EMC80910.1 - 0.23 10.1 6.1 0.31 9.6 6.1 1.2 1 0 0 1 1 1 0 AAA domain Laminin_I PF06008.14 EMC80910.1 - 0.24 11.1 14.7 1.1 8.9 7.6 2.2 2 0 0 2 2 2 0 Laminin Domain I Spc7 PF08317.11 EMC80910.1 - 0.39 9.5 20.7 0.081 11.8 15.0 2.1 1 1 0 2 2 2 0 Spc7 kinetochore protein DUF1690 PF07956.11 EMC80910.1 - 0.59 10.6 15.4 0.27 11.6 10.9 2.3 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) YlqD PF11068.8 EMC80910.1 - 0.68 10.3 10.7 16 5.9 8.2 2.3 2 0 0 2 2 2 0 YlqD protein HAUS6_N PF14661.6 EMC80910.1 - 1 8.9 10.6 0.55 9.8 8.1 1.7 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus DUF1664 PF07889.12 EMC80910.1 - 1.5 8.9 6.2 2.1 8.4 2.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) LPP PF04728.13 EMC80910.1 - 1.5 9.3 5.6 3.3 8.1 0.4 3.0 3 0 0 3 3 3 0 Lipoprotein leucine-zipper Snapin_Pallidin PF14712.6 EMC80910.1 - 1.6 9.2 8.4 0.55 10.7 2.5 2.4 2 0 0 2 2 2 0 Snapin/Pallidin DUF4680 PF15730.5 EMC80910.1 - 1.8 8.9 5.3 1.6 9.0 3.6 1.7 2 0 0 2 2 1 0 Domain of unknown function (DUF4680) FlaC_arch PF05377.11 EMC80910.1 - 2 8.9 10.0 7.6 7.0 1.1 3.4 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) GAS PF13851.6 EMC80910.1 - 2.2 7.6 16.0 0.35 10.2 10.8 2.0 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 EMC80910.1 - 2.5 8.1 21.8 13 5.8 21.4 2.4 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 bZIP_1 PF00170.21 EMC80910.1 - 3.3 7.9 16.1 1.5 8.9 0.2 3.1 3 0 0 3 3 2 0 bZIP transcription factor Macoilin PF09726.9 EMC80910.1 - 3.7 6.0 11.3 5.2 5.5 11.3 1.1 1 0 0 1 1 1 0 Macoilin family Atg14 PF10186.9 EMC80910.1 - 3.8 6.5 15.8 12 4.9 15.8 1.7 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 HemX PF04375.14 EMC80910.1 - 4.3 6.5 13.1 0.47 9.7 8.1 1.8 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase End3 PF12761.7 EMC80910.1 - 4.5 7.4 16.3 3.7 7.7 5.9 3.0 2 1 1 3 3 3 0 Actin cytoskeleton-regulatory complex protein END3 Cluap1 PF10234.9 EMC80910.1 - 5.2 6.4 12.1 1.5 8.1 8.5 1.8 2 0 0 2 2 2 0 Clusterin-associated protein-1 Phage_GPO PF05929.11 EMC80910.1 - 8.1 6.0 8.8 1.6 8.3 4.1 1.9 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF4407 PF14362.6 EMC80910.1 - 8.4 5.7 8.7 15 4.9 8.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) SIR2 PF02146.17 EMC80911.1 - 3.9e-26 92.0 0.0 9.1e-18 64.8 0.0 2.1 1 1 1 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.22 EMC80911.1 - 0.00094 18.9 0.0 0.063 13.0 0.0 2.2 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain bZIP_1 PF00170.21 EMC80912.1 - 1.9e-13 50.3 27.6 4.8e-13 49.0 15.6 2.1 1 1 1 2 2 2 2 bZIP transcription factor bZIP_2 PF07716.15 EMC80912.1 - 1.6e-09 37.7 24.4 3.5e-09 36.6 10.4 2.4 1 1 1 2 2 2 2 Basic region leucine zipper bZIP_Maf PF03131.17 EMC80912.1 - 3.9e-05 24.1 11.9 3.9e-05 24.1 11.9 1.5 1 1 0 1 1 1 1 bZIP Maf transcription factor ADIP PF11559.8 EMC80912.1 - 0.01 15.9 12.0 0.015 15.4 12.0 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding ZapB PF06005.12 EMC80912.1 - 0.012 16.0 6.6 0.012 16.0 6.6 2.2 1 1 1 2 2 2 0 Cell division protein ZapB DUF1664 PF07889.12 EMC80912.1 - 0.013 15.6 2.2 0.016 15.2 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) RNA_polI_A14 PF08203.11 EMC80912.1 - 0.031 15.0 2.7 0.061 14.0 2.7 1.5 1 0 0 1 1 1 0 Yeast RNA polymerase I subunit RPA14 DUF724 PF05266.14 EMC80912.1 - 0.076 12.8 6.3 0.11 12.4 6.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) HAUS-augmin3 PF14932.6 EMC80912.1 - 0.08 12.5 10.0 0.096 12.3 9.6 1.3 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF4407 PF14362.6 EMC80912.1 - 0.082 12.2 3.5 0.1 12.0 3.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SOGA PF11365.8 EMC80912.1 - 0.094 13.9 11.0 0.1 13.8 8.4 2.0 1 1 1 2 2 2 0 Protein SOGA KASH_CCD PF14662.6 EMC80912.1 - 0.28 11.0 14.7 0.3 10.9 14.1 1.4 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Spc7 PF08317.11 EMC80912.1 - 0.5 9.2 11.5 0.58 9.0 11.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein SlyX PF04102.12 EMC80912.1 - 0.63 10.7 6.9 0.25 12.0 2.9 2.1 1 1 1 2 2 2 0 SlyX MCU PF04678.13 EMC80912.1 - 0.79 9.8 3.7 1 9.4 3.7 1.3 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Pkinase PF00069.25 EMC80913.1 - 4.3e-61 206.6 0.0 6.1e-61 206.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC80913.1 - 3.2e-34 118.4 0.0 1.4e-32 113.0 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC80913.1 - 8.9e-05 21.4 0.0 0.00013 20.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EMC80913.1 - 0.0039 16.2 0.0 0.0054 15.7 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EMC80913.1 - 0.0055 16.1 0.0 0.01 15.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EMC80913.1 - 0.014 15.3 0.0 0.029 14.3 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EMC80913.1 - 0.029 13.5 0.0 0.048 12.7 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 EMC80913.1 - 0.15 11.4 0.8 0.32 10.3 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family BTB PF00651.31 EMC80914.1 - 1e-33 115.8 0.1 1.7e-33 115.2 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 EMC80914.1 - 2.6e-24 84.5 19.3 1.2e-07 31.9 0.5 4.8 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 EMC80914.1 - 1.5e-16 59.8 23.1 1.3e-05 25.3 1.4 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC80914.1 - 2.5e-14 52.7 20.5 0.0006 20.4 0.9 4.8 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC80914.1 - 0.0053 16.7 0.3 0.0053 16.7 0.3 4.3 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC80914.1 - 0.0063 16.8 12.4 3.4 8.1 0.5 4.6 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.8 EMC80914.1 - 0.029 14.7 1.7 0.43 10.9 1.8 2.4 2 0 0 2 2 2 0 zinc-finger-containing domain zf-C2H2_9 PF16293.5 EMC80914.1 - 0.033 14.0 2.2 7.9 6.4 0.0 3.7 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) zinc_ribbon_15 PF17032.5 EMC80914.1 - 0.034 14.9 5.4 2.8 8.7 0.4 2.5 1 1 1 2 2 2 0 zinc-ribbon family zf-met PF12874.7 EMC80914.1 - 0.058 13.8 0.5 0.058 13.8 0.5 4.4 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 EMC80914.1 - 0.072 12.9 6.8 0.25 11.1 0.1 3.3 3 0 0 3 3 3 0 zinc-finger C2H2-type GAGA PF09237.11 EMC80914.1 - 0.17 11.7 8.0 0.33 10.8 0.1 3.7 1 1 3 4 4 4 0 GAGA factor GATA PF00320.27 EMC80914.1 - 0.3 10.7 1.8 4.9 6.8 0.1 2.9 3 0 0 3 3 3 0 GATA zinc finger zinc-ribbons_6 PF07191.12 EMC80914.1 - 1.1 9.3 7.5 2.2 8.3 4.0 2.7 1 1 1 2 2 2 0 zinc-ribbons zf-C2H2_2 PF12756.7 EMC80914.1 - 1.9 8.9 15.1 3.3 8.1 1.1 4.3 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) DZR PF12773.7 EMC80914.1 - 2.1 8.5 7.8 1.2e+02 2.8 7.8 2.4 1 1 0 1 1 1 0 Double zinc ribbon Baculo_IE-1 PF05290.11 EMC80914.1 - 2.4 8.1 7.8 13 5.7 1.4 2.9 2 1 1 3 3 3 0 Baculovirus immediate-early protein (IE-0) Zn-ribbon_8 PF09723.10 EMC80914.1 - 2.5 8.3 11.8 0.62 10.2 1.5 3.6 3 0 0 3 3 3 0 Zinc ribbon domain zf-C2HE PF16278.5 EMC80914.1 - 5.8 7.4 14.5 18 5.9 1.7 4.4 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-Di19 PF05605.12 EMC80914.1 - 6.9 7.1 11.7 0.14 12.5 1.3 2.8 1 1 2 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_7 PF15269.6 EMC80914.1 - 8.8 6.5 11.1 5.6 7.1 0.3 3.3 2 1 1 3 3 3 0 Zinc-finger Nrf1_activ_bdg PF10492.9 EMC80915.1 - 7.7e-05 23.3 35.8 25 5.6 0.2 9.8 1 1 7 8 8 8 7 Nrf1 activator activation site binding domain Acetone_carb_G PF08882.11 EMC80915.1 - 1.7 8.8 21.4 1.2e+02 2.8 0.3 7.6 1 1 7 8 8 8 0 Acetone carboxylase gamma subunit GTP_EFTU PF00009.27 EMC80916.1 - 5.2e-65 218.6 0.0 7.1e-65 218.2 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EMC80916.1 - 2.1e-34 117.9 0.0 8.9e-34 115.9 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 EMC80916.1 - 4.9e-23 81.0 0.0 1.2e-22 79.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EMC80916.1 - 2.2e-13 50.1 0.0 4.9e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EMC80916.1 - 1.2e-12 48.0 0.2 7.5e-12 45.5 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EMC80916.1 - 1.5e-05 25.0 0.1 3.3e-05 23.9 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Pkinase PF00069.25 EMC80917.1 - 6.8e-76 255.1 1.5 2.3e-75 253.4 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC80917.1 - 1.4e-36 126.2 0.0 3.6e-36 124.8 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EMC80917.1 - 2e-06 27.3 0.5 2.8e-05 23.6 0.1 2.5 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-C4H2 PF10146.9 EMC80917.1 - 0.0023 18.3 9.9 0.0058 17.0 9.9 1.7 1 0 0 1 1 1 1 Zinc finger-containing protein BLOC1_2 PF10046.9 EMC80917.1 - 0.064 13.6 9.5 0.25 11.7 3.6 2.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fib_alpha PF08702.10 EMC80917.1 - 0.099 12.8 12.1 0.15 12.2 5.8 2.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family APH PF01636.23 EMC80917.1 - 0.14 12.1 0.7 0.3 11.0 0.0 2.0 2 1 0 2 2 2 0 Phosphotransferase enzyme family ER PF01133.17 EMC80917.1 - 0.23 11.5 1.6 0.52 10.4 0.2 2.3 2 1 1 3 3 2 0 Enhancer of rudimentary TACC_C PF05010.14 EMC80917.1 - 0.26 11.1 18.8 0.43 10.3 18.8 1.3 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal RasGAP_C PF03836.15 EMC80917.1 - 0.27 11.4 10.8 0.95 9.6 5.4 2.8 1 1 1 2 2 2 0 RasGAP C-terminus DUF3847 PF12958.7 EMC80917.1 - 0.27 11.4 0.1 0.27 11.4 0.1 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3847) Sec34 PF04136.15 EMC80917.1 - 0.32 10.9 9.6 3.7 7.4 4.3 2.6 1 1 1 2 2 2 0 Sec34-like family TPR_MLP1_2 PF07926.12 EMC80917.1 - 0.62 10.1 20.4 1.5 8.9 20.4 1.7 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DHR10 PF18595.1 EMC80917.1 - 0.65 10.1 17.5 1.7 8.7 17.5 1.8 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain FlaC_arch PF05377.11 EMC80917.1 - 0.9 10.0 8.5 2.1 8.8 0.4 3.4 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) SpecificRecomb PF10136.9 EMC80917.1 - 1.2 7.4 5.4 2.9 6.1 0.0 2.1 2 0 0 2 2 2 0 Site-specific recombinase Prominin PF05478.11 EMC80917.1 - 1.3 6.9 7.5 2.1 6.2 7.5 1.3 1 0 0 1 1 1 0 Prominin Seryl_tRNA_N PF02403.22 EMC80917.1 - 1.4 9.1 12.3 4.8 7.5 12.3 2.0 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF3450 PF11932.8 EMC80917.1 - 1.5 8.0 15.3 0.28 10.5 8.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Occludin_ELL PF07303.13 EMC80917.1 - 1.6 9.5 11.0 9.9 7.0 4.6 2.8 1 1 1 2 2 2 0 Occludin homology domain FapA PF03961.13 EMC80917.1 - 1.6 7.2 12.3 3.2 6.3 12.0 1.7 1 1 0 1 1 1 0 Flagellar Assembly Protein A OmpH PF03938.14 EMC80917.1 - 2.6 8.4 20.5 7.3 6.9 20.0 1.9 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) HIP1_clath_bdg PF16515.5 EMC80917.1 - 2.6 8.7 15.6 1.7 9.3 12.6 2.2 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DED PF01335.21 EMC80917.1 - 2.7 8.4 6.3 1.7 9.0 0.2 3.4 3 2 1 4 4 3 0 Death effector domain TMPIT PF07851.13 EMC80917.1 - 7.6 5.7 10.7 16 4.7 10.7 1.5 1 0 0 1 1 1 0 TMPIT-like protein Uso1_p115_C PF04871.13 EMC80917.1 - 8 6.8 20.5 7.8 6.9 11.9 2.3 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region AAA_18 PF13238.6 EMC80918.1 - 2.9e-08 34.3 0.0 5e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EMC80918.1 - 0.0033 17.5 0.1 0.013 15.5 0.1 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase PRK PF00485.18 EMC80918.1 - 0.0036 17.1 0.3 0.042 13.6 0.3 2.1 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.6 EMC80918.1 - 0.014 15.5 0.0 0.027 14.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain MobB PF03205.14 EMC80918.1 - 0.042 13.8 0.2 0.13 12.1 0.2 1.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B T2SSE PF00437.20 EMC80918.1 - 0.099 11.7 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein BNIP2 PF12496.8 EMC80919.1 - 6.3e-42 143.2 0.3 1.1e-41 142.5 0.3 1.4 1 0 0 1 1 1 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO_2 PF13716.6 EMC80919.1 - 1.4e-31 109.5 0.2 1.8e-31 109.1 0.2 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 EMC80919.1 - 8.6e-08 32.1 0.2 1.3e-07 31.5 0.2 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain Glyco_transf_10 PF00852.19 EMC80920.1 - 1.6e-66 223.4 0.4 2.1e-66 223.0 0.4 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 EMC80920.1 - 1.2e-39 135.2 0.3 2e-39 134.4 0.3 1.4 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Malt_amylase_C PF16657.5 EMC80920.1 - 0.018 15.1 0.0 0.036 14.2 0.0 1.5 1 0 0 1 1 1 0 Maltogenic Amylase, C-terminal domain Glyco_trans_1_2 PF13524.6 EMC80920.1 - 0.12 12.8 0.0 0.22 11.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 Apolipoprotein PF01442.18 EMC80922.1 - 0.012 15.5 0.5 0.014 15.3 0.5 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain FAM25 PF15825.5 EMC80922.1 - 0.041 14.2 4.2 0.056 13.8 3.2 1.7 1 1 1 2 2 2 0 FAM25 family DUF883 PF05957.13 EMC80922.1 - 0.054 14.1 3.8 0.11 13.2 3.8 1.5 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) DUF4230 PF14014.6 EMC80922.1 - 0.12 12.6 2.3 0.21 11.9 2.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4230) YtxH PF12732.7 EMC80922.1 - 0.21 12.1 6.1 0.77 10.3 6.1 1.8 1 1 0 1 1 1 0 YtxH-like protein V-ATPase_G_2 PF16999.5 EMC80922.1 - 1.1 9.7 8.4 0.55 10.7 1.4 1.9 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit Phage_holin_7_1 PF16081.5 EMC80922.1 - 5.4 7.2 9.6 8.9 6.5 9.6 1.5 1 1 0 1 1 1 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family Synuclein PF01387.17 EMC80923.1 - 2.4e-51 173.5 23.8 2.6e-51 173.3 23.8 1.0 1 0 0 1 1 1 1 Synuclein YtxH PF12732.7 EMC80923.1 - 0.41 11.2 8.4 0.71 10.5 1.6 2.0 1 1 1 2 2 2 0 YtxH-like protein C1q PF00386.21 EMC80924.1 - 8.3e-17 61.6 0.2 2.8e-16 59.9 0.2 2.0 1 0 0 1 1 1 1 C1q domain DUF3782 PF12644.7 EMC80924.1 - 0.018 15.2 0.1 0.018 15.2 0.1 5.2 6 1 1 7 7 7 0 Protein of unknown function (DUF3782) DUF1664 PF07889.12 EMC80924.1 - 0.046 13.8 0.3 0.046 13.8 0.3 6.7 2 2 3 7 7 7 0 Protein of unknown function (DUF1664) DASH_Dam1 PF08653.10 EMC80924.1 - 0.47 10.3 15.9 4.8 7.0 0.0 6.0 7 0 0 7 7 7 0 DASH complex subunit Dam1 Nup54_C PF18437.1 EMC80924.1 - 0.51 10.3 7.9 0.19 11.6 2.7 3.0 3 0 0 3 3 3 0 Nup54 C-terminal interacting domain MbeD_MobD PF04899.12 EMC80924.1 - 1.3 9.2 12.6 0.41 10.8 0.6 4.1 5 0 0 5 5 5 0 MbeD/MobD like Pkinase_Tyr PF07714.17 EMC80925.1 - 7e-38 130.4 0.0 9.8e-38 129.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC80925.1 - 1.6e-37 129.3 0.0 2.9e-37 128.5 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.12 EMC80925.1 - 6e-16 57.6 0.7 1.2e-15 56.6 0.7 1.6 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Activin_recp PF01064.23 EMC80925.1 - 4.6e-13 50.1 12.1 4.6e-13 50.1 12.1 2.5 2 0 0 2 2 2 1 Activin types I and II receptor domain Pkinase_fungal PF17667.1 EMC80925.1 - 2.3e-05 23.4 0.0 3.5e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 EMC80925.1 - 0.028 14.0 0.0 0.053 13.1 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 EMC80925.1 - 0.078 11.9 0.1 0.17 10.8 0.0 1.5 2 0 0 2 2 2 0 Haspin like kinase domain Comm PF15957.5 EMC80925.1 - 0.11 12.9 0.6 1.8 8.9 0.1 2.7 3 0 0 3 3 3 0 Commissureless APH PF01636.23 EMC80925.1 - 0.22 11.4 0.0 0.52 10.2 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family TIR PF01582.20 EMC80926.1 - 3.3e-28 98.7 0.0 4.9e-28 98.1 0.0 1.2 1 0 0 1 1 1 1 TIR domain ig PF00047.25 EMC80926.1 - 8.7e-07 29.0 0.0 1.8e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain TIR_2 PF13676.6 EMC80926.1 - 9e-07 29.5 0.0 1.7e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 TIR domain Ig_3 PF13927.6 EMC80926.1 - 2.1e-06 28.3 0.0 4.6e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC80926.1 - 2.6e-06 27.4 0.0 5.1e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC80926.1 - 0.00012 22.3 0.0 0.00036 20.8 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC80928.1 - 0.0002 21.4 0.0 0.0002 21.3 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC80928.1 - 0.00054 20.2 0.1 0.00072 19.8 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC80928.1 - 0.00062 19.9 0.1 0.00073 19.7 0.1 1.2 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 EMC80928.1 - 0.0013 18.9 0.1 0.0015 18.7 0.1 1.3 1 1 0 1 1 1 1 Immunoglobulin domain Ig_6 PF18452.1 EMC80928.1 - 0.0015 18.1 0.1 0.0025 17.3 0.0 1.5 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 EMC80928.1 - 0.0018 18.9 0.1 0.0022 18.5 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin domain V-set_CD47 PF08204.11 EMC80928.1 - 0.015 15.3 0.2 0.018 15.1 0.2 1.2 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain Izumo-Ig PF16706.5 EMC80928.1 - 0.019 15.0 0.0 0.02 15.0 0.0 1.3 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 EMC80929.1 - 1.1e-14 53.7 0.0 1.7e-14 53.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC80929.1 - 0.00098 19.4 0.0 0.0021 18.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC80929.1 - 0.0029 18.2 0.0 0.0064 17.1 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC80929.1 - 0.013 15.6 0.0 0.06 13.4 0.0 2.0 2 0 0 2 2 2 0 Immunoglobulin I-set domain ig PF00047.25 EMC80929.1 - 0.024 14.8 0.0 0.092 12.9 0.0 1.9 1 1 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 EMC80929.1 - 0.04 14.1 0.0 0.4 10.9 0.0 2.2 1 1 0 1 1 1 0 Immunoglobulin V-set domain Glycos_transf_2 PF00535.26 EMC80930.1 - 1.4e-28 99.8 0.0 2.2e-28 99.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 EMC80930.1 - 4.8e-18 65.6 0.1 7.6e-18 65.0 0.1 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 EMC80930.1 - 2e-05 24.6 0.0 0.001 19.0 0.0 2.1 2 0 0 2 2 2 1 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.6 EMC80930.1 - 0.016 15.9 0.1 0.065 14.0 0.0 1.9 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like Glyco_transf_7C PF02709.14 EMC80930.1 - 0.14 11.8 0.0 0.5 10.0 0.0 1.9 2 0 0 2 2 2 0 N-terminal domain of galactosyltransferase GTF2I PF02946.14 EMC80931.1 - 7e-184 596.3 14.4 3.4e-33 113.5 0.0 6.2 6 0 0 6 6 6 6 GTF2I-like repeat REV1_C PF16727.5 EMC80931.1 - 0.0088 16.4 0.7 67 4.0 0.0 4.3 4 0 0 4 4 4 0 DNA repair protein REV1 C-terminal domain TetR_C_37 PF18665.1 EMC80931.1 - 0.11 13.1 0.0 11 6.7 0.0 2.9 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF1115 PF06544.12 EMC80931.1 - 0.28 11.3 1.0 9.7 6.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1115) SH3_1 PF00018.28 EMC80932.1 - 4.8e-31 106.1 0.5 1.1e-14 53.7 0.1 3.3 3 0 0 3 3 3 2 SH3 domain SH3_9 PF14604.6 EMC80932.1 - 2.6e-24 84.8 0.2 9.2e-12 44.6 0.1 3.0 3 0 0 3 3 3 2 Variant SH3 domain NECFESHC PF16621.5 EMC80932.1 - 3.6e-22 78.1 9.1 6.7e-22 77.2 9.1 1.5 1 0 0 1 1 1 1 SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1 SH3_2 PF07653.17 EMC80932.1 - 8.3e-22 76.6 0.0 5.6e-12 45.1 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.24 EMC80932.1 - 5.7e-13 48.8 0.3 9.9e-13 48.1 0.3 1.4 1 0 0 1 1 1 1 PX domain hSH3 PF14603.6 EMC80932.1 - 0.00014 22.2 0.0 0.068 13.6 0.0 2.4 2 0 0 2 2 2 2 Helically-extended SH3 domain SH3_3 PF08239.11 EMC80932.1 - 0.015 15.6 0.7 3.6 8.0 0.0 2.4 2 0 0 2 2 2 0 Bacterial SH3 domain CENP-N PF05238.13 EMC80932.1 - 0.035 13.4 0.1 0.061 12.6 0.1 1.4 1 0 0 1 1 1 0 Kinetochore protein CHL4 like G-patch PF01585.23 EMC80934.1 - 4.3e-17 61.7 0.7 8.4e-17 60.8 0.7 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EMC80934.1 - 5.8e-09 35.9 0.2 5.8e-09 35.9 0.2 2.5 3 0 0 3 3 3 1 G-patch domain IQ PF00612.27 EMC80935.1 - 4.2e-12 44.7 22.5 0.00017 21.1 2.2 3.9 3 0 0 3 3 3 3 IQ calmodulin-binding motif Radical_SAM_N PF08497.10 EMC80935.1 - 0.055 12.7 1.4 0.075 12.2 1.4 1.2 1 0 0 1 1 1 0 Radical SAM N-terminal Rrp15p PF07890.12 EMC80937.1 - 7.9e-33 113.6 14.5 7.9e-33 113.6 14.5 1.5 2 0 0 2 2 2 1 Rrp15p TGFb_propeptide PF00688.18 EMC80938.1 - 2.3e-36 125.8 0.0 3e-36 125.4 0.0 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 EMC80938.1 - 5.2e-24 85.2 1.3 1.4e-23 83.8 1.3 1.8 1 0 0 1 1 1 1 Transforming growth factor beta like domain SPEG_u2 PF16650.5 EMC80938.1 - 0.75 10.0 4.4 0.16 12.1 0.5 1.8 2 0 0 2 2 2 0 Unstructured region on SPEG complex protein Abhydrolase_2 PF02230.16 EMC80939.1 - 1.4e-36 126.4 0.1 1.5e-36 126.2 0.1 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 EMC80939.1 - 7.5e-07 29.2 0.1 0.00034 20.5 0.0 2.4 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMC80939.1 - 8.1e-07 28.5 0.1 0.0016 17.8 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EMC80939.1 - 1.5e-05 24.6 1.3 0.001 18.6 0.0 2.1 1 1 1 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.18 EMC80939.1 - 2.6e-05 23.9 0.0 3.4e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.7 EMC80939.1 - 0.00041 20.1 0.0 0.00057 19.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 EMC80939.1 - 0.0035 17.0 0.0 0.0035 17.0 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Abhydrolase_1 PF00561.20 EMC80939.1 - 0.026 14.2 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 EMC80939.1 - 0.039 13.8 0.0 0.061 13.2 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Thioesterase PF00975.20 EMC80939.1 - 0.062 13.4 0.1 0.12 12.5 0.0 1.6 1 1 1 2 2 2 0 Thioesterase domain Cbl_N3 PF02762.14 EMC80939.1 - 0.085 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, SH2-like domain FSH1 PF03959.13 EMC80939.1 - 0.099 12.3 0.1 0.23 11.1 0.1 1.8 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Cation_efflux PF01545.21 EMC80940.1 - 4.5e-39 134.3 6.8 1.8e-38 132.3 6.8 1.8 1 1 0 1 1 1 1 Cation efflux family Inositol_P PF00459.25 EMC80941.1 - 1.4e-59 201.8 0.4 1.8e-59 201.5 0.4 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family tRNA-synt_1 PF00133.22 EMC80942.1 - 1.9e-166 554.8 0.2 2.9e-166 554.3 0.2 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EMC80942.1 - 8.4e-26 90.8 0.0 2.2e-25 89.4 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EMC80942.1 - 5.4e-25 87.9 4.3 3.6e-17 62.2 0.0 3.6 4 0 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EMC80942.1 - 0.00015 21.3 0.0 0.00027 20.5 0.0 1.3 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EMC80942.1 - 0.00022 20.7 0.0 0.061 12.7 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain RAB3GAP2_C PF14656.6 EMC80943.1 - 1.4e-232 773.3 17.6 1.8e-232 772.9 17.6 1.2 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit C-terminus RAB3GAP2_N PF14655.6 EMC80943.1 - 7.1e-166 552.6 0.0 1.1e-165 551.9 0.0 1.3 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus SRP54_N PF02881.19 EMC80943.1 - 0.27 11.5 6.6 0.83 9.9 0.0 4.4 4 1 1 5 5 5 0 SRP54-type protein, helical bundle domain Pkinase PF00069.25 EMC80944.1 - 6.9e-76 255.1 0.0 1e-75 254.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC80944.1 - 5.6e-44 150.4 0.0 8.3e-44 149.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 EMC80944.1 - 9.4e-21 73.3 0.0 1.7e-20 72.5 0.0 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 EMC80944.1 - 4.3e-07 29.5 0.0 9.8e-07 28.4 0.0 1.6 2 0 0 2 2 2 1 Kinase-like UBA PF00627.31 EMC80944.1 - 8.6e-07 28.7 0.0 1.6e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain RIO1 PF01163.22 EMC80944.1 - 0.00055 19.6 0.2 0.0011 18.6 0.2 1.4 1 0 0 1 1 1 1 RIO1 family UBA_2 PF08587.11 EMC80944.1 - 0.0035 17.4 0.1 0.0089 16.1 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) Kdo PF06293.14 EMC80944.1 - 0.0074 15.7 0.1 0.015 14.7 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EMC80944.1 - 0.072 12.0 0.0 0.13 11.2 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 EMC80944.1 - 0.076 12.9 0.1 0.26 11.2 0.1 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Profilin PF00235.19 EMC80945.1 - 2.7e-23 82.6 0.1 3.2e-23 82.4 0.1 1.0 1 0 0 1 1 1 1 Profilin MOSC PF03473.17 EMC80946.1 - 2e-32 112.0 0.0 2.7e-32 111.5 0.0 1.2 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 EMC80946.1 - 1.6e-21 76.4 0.0 4.1e-21 75.1 0.0 1.7 2 0 0 2 2 2 1 MOSC N-terminal beta barrel domain Homeodomain PF00046.29 EMC80947.1 - 1.4e-19 69.7 0.6 1.5e-19 69.6 0.6 1.0 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC80947.1 - 0.00053 19.8 0.1 0.0007 19.4 0.1 1.2 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 EMC80947.1 - 0.045 13.2 0.1 0.047 13.2 0.1 1.1 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Trypan_PARP PF05887.11 EMC80948.1 - 0.0031 17.5 24.9 0.0031 17.5 24.9 5.3 2 1 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) Zip PF02535.22 EMC80948.1 - 0.0046 16.2 9.0 0.0046 16.2 9.0 5.6 2 1 0 2 2 2 1 ZIP Zinc transporter Patatin PF01734.22 EMC80949.1 - 5.9e-20 72.3 1.2 4.7e-18 66.1 1.2 2.3 1 1 0 1 1 1 1 Patatin-like phospholipase DUF4347 PF14252.6 EMC80950.1 - 0.0003 20.7 0.0 0.0005 20.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4347) IQ PF00612.27 EMC80950.1 - 0.086 12.7 0.2 0.086 12.7 0.2 3.9 4 0 0 4 4 4 0 IQ calmodulin-binding motif Phostensin PF13914.6 EMC80951.1 - 4.4e-41 140.7 12.2 9.9e-41 139.6 0.9 2.9 3 0 0 3 3 3 2 Phostensin PP1-binding and SH3-binding region PA26 PF04636.13 EMC80951.1 - 0.88 8.4 2.1 1.1 8.1 2.1 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Torsin PF06309.11 EMC80952.1 - 3.1e-14 53.2 0.1 8.9e-14 51.7 0.0 1.7 2 0 0 2 2 2 1 Torsin AAA_16 PF13191.6 EMC80952.1 - 0.00013 22.4 0.0 0.039 14.3 0.0 3.1 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EMC80952.1 - 0.00091 19.5 0.2 0.18 12.1 0.2 2.7 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMC80952.1 - 0.01 16.4 0.0 0.029 14.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EMC80952.1 - 0.016 15.6 0.0 0.034 14.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 EMC80952.1 - 0.05 13.3 0.0 0.091 12.5 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein KAP_NTPase PF07693.14 EMC80952.1 - 0.083 12.1 0.0 0.14 11.4 0.0 1.5 1 1 0 1 1 1 0 KAP family P-loop domain Pkinase_Tyr PF07714.17 EMC80953.1 - 5.8e-84 281.4 0.0 7.8e-84 281.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC80953.1 - 2e-41 142.1 0.0 1.1e-40 139.7 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain F5_F8_type_C PF00754.25 EMC80953.1 - 1.6e-21 76.7 0.0 4.7e-21 75.2 0.0 1.8 2 0 0 2 2 2 1 F5/8 type C domain TMEM154 PF15102.6 EMC80953.1 - 0.0047 16.8 0.4 0.0078 16.1 0.4 1.3 1 0 0 1 1 1 1 TMEM154 protein family Haspin_kinase PF12330.8 EMC80953.1 - 0.022 13.7 0.0 0.037 13.0 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain DUF2062 PF09835.9 EMC80953.1 - 0.038 13.9 0.0 0.072 12.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) Mid2 PF04478.12 EMC80953.1 - 0.11 12.3 0.1 0.23 11.3 0.1 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor DUF2475 PF10629.9 EMC80954.1 - 1e-09 38.4 0.1 1.1e-09 38.4 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2475) DUF2475 PF10629.9 EMC80955.1 - 2.9e-09 37.0 1.3 0.0012 19.0 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2475) GDA1_CD39 PF01150.17 EMC80956.1 - 2.1e-40 138.7 0.0 2.8e-40 138.3 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family COX7a PF02238.15 EMC80957.1 - 2.3e-09 37.5 0.0 3.4e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII MTA_R1 PF17226.2 EMC80958.1 - 8.8e-30 102.7 1.1 2.3e-29 101.4 0.9 1.9 2 0 0 2 2 2 1 MTA R1 domain BAH PF01426.18 EMC80958.1 - 7.8e-29 100.0 0.9 3e-28 98.1 0.9 1.9 1 1 0 1 1 1 1 BAH domain ELM2 PF01448.24 EMC80958.1 - 9.7e-17 61.5 0.2 9.7e-17 61.5 0.2 2.8 3 0 0 3 3 3 1 ELM2 domain GATA PF00320.27 EMC80958.1 - 1.4e-09 37.4 8.0 2.7e-09 36.5 8.0 1.5 1 0 0 1 1 1 1 GATA zinc finger Myb_DNA-binding PF00249.31 EMC80958.1 - 7e-06 26.1 0.1 1.8e-05 24.9 0.1 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EMC80958.1 - 0.0084 16.0 0.1 0.027 14.3 0.1 1.8 1 0 0 1 1 1 1 Myb DNA-binding like Herpes_US12 PF05363.12 EMC80958.1 - 0.053 14.2 0.0 0.18 12.6 0.0 1.9 1 0 0 1 1 1 0 Herpesvirus US12 family 3-HAO PF06052.12 EMC80959.1 - 1.4e-75 252.0 0.1 8.8e-71 236.4 0.2 2.0 2 0 0 2 2 2 2 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 EMC80959.1 - 1.4e-11 43.9 0.0 5.6e-05 22.8 0.0 2.4 2 0 0 2 2 2 2 Cupin domain AraC_binding PF02311.19 EMC80959.1 - 0.0062 16.4 0.0 1.2 9.1 0.0 2.4 2 0 0 2 2 2 2 AraC-like ligand binding domain Cupin_3 PF05899.12 EMC80959.1 - 0.0088 15.7 0.0 0.49 10.1 0.0 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF861) Cupin_1 PF00190.22 EMC80959.1 - 0.089 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Cupin DUF2428 PF10350.9 EMC80961.1 - 7e-104 346.9 2.4 8.5e-104 346.7 0.8 2.1 2 0 0 2 2 2 1 Putative death-receptor fusion protein (DUF2428) MyTH4 PF00784.17 EMC80962.1 - 2.6e-33 114.7 1.6 2.6e-33 114.7 1.6 2.7 3 0 0 3 3 3 1 MyTH4 domain PH PF00169.29 EMC80962.1 - 8.7e-27 93.7 0.5 2.9e-18 66.3 0.1 3.7 3 0 0 3 3 3 2 PH domain FERM_M PF00373.18 EMC80962.1 - 7.6e-13 48.9 0.0 7.6e-13 48.9 0.0 2.5 2 0 0 2 2 2 1 FERM central domain PH_11 PF15413.6 EMC80962.1 - 7.6e-07 29.5 0.7 7.6e-07 29.5 0.7 4.2 3 2 0 3 3 3 1 Pleckstrin homology domain DLIC PF05783.11 EMC80963.1 - 1.6e-10 40.5 0.1 3.3e-10 39.4 0.0 1.5 1 1 0 1 1 1 1 Dynein light intermediate chain (DLIC) Gtr1_RagA PF04670.12 EMC80963.1 - 0.00016 21.1 0.0 0.00027 20.4 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EMC80963.1 - 0.0022 18.2 0.0 0.0055 16.9 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Elongin_A PF06881.11 EMC80963.1 - 0.32 11.6 6.4 0.99 10.0 2.4 2.6 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A DnaJ PF00226.31 EMC80964.1 - 6.6e-18 64.6 1.4 1.9e-17 63.1 1.4 1.8 1 0 0 1 1 1 1 DnaJ domain Myb_DNA-binding PF00249.31 EMC80964.1 - 4.9e-12 45.8 0.6 4.2e-07 30.1 0.2 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EMC80964.1 - 2.4e-06 27.7 0.1 0.012 15.9 0.3 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain DUF4234 PF14018.6 EMC80964.1 - 0.053 13.7 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4234) zf-HC5HC2H_2 PF13832.6 EMC80965.1 - 9.9e-31 106.2 21.0 2.6e-30 104.8 11.3 2.5 2 0 0 2 2 2 2 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EMC80965.1 - 3.6e-20 72.0 10.6 3.6e-20 72.0 10.6 3.3 2 1 1 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 EMC80965.1 - 2.8e-13 49.2 4.2 2.8e-13 49.2 4.2 2.7 3 0 0 3 3 3 1 PHD-finger PHD PF00628.29 EMC80965.1 - 1.9e-08 34.1 9.7 1.9e-08 34.1 9.7 3.0 2 1 0 2 2 2 1 PHD-finger zf-RING-like PF08746.11 EMC80965.1 - 5.2 7.5 12.8 6.2 7.2 3.2 3.0 2 0 0 2 2 2 0 RING-like domain LIM PF00412.22 EMC80966.1 - 2.2e-08 34.2 6.9 2.7e-08 33.9 6.9 1.2 1 0 0 1 1 1 1 LIM domain Nebulin PF00880.18 EMC80966.1 - 0.0024 17.8 0.3 0.0024 17.8 0.3 1.9 2 1 0 2 2 2 1 Nebulin repeat Nebulin PF00880.18 EMC80967.1 - 1.2e-145 472.3 97.1 6.8e-12 45.0 0.1 22.4 22 0 0 22 22 22 22 Nebulin repeat SH3_9 PF14604.6 EMC80967.1 - 1.6e-15 56.6 0.1 3.2e-15 55.7 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC80967.1 - 1.3e-12 47.1 0.5 2.7e-12 46.1 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EMC80967.1 - 0.00012 21.7 0.0 0.00027 20.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain PI31_Prot_C PF08577.11 EMC80967.1 - 0.047 14.9 0.4 25 6.1 0.0 4.0 1 1 2 3 3 3 0 PI31 proteasome regulator DUF4790 PF16037.5 EMC80967.1 - 0.17 12.4 4.3 0.68 10.4 0.0 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4790) PSI PF01437.25 EMC80968.1 - 4.4e-08 33.5 11.3 7.5e-08 32.8 11.3 1.4 1 0 0 1 1 1 1 Plexin repeat MGC-24 PF05283.11 EMC80968.1 - 0.0019 18.6 8.6 0.006 17.0 8.6 1.8 1 1 0 1 1 1 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF116 PF01976.17 EMC80968.1 - 0.043 13.3 1.0 0.07 12.6 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF116 DUF5305 PF17231.2 EMC80968.1 - 0.091 12.1 0.1 0.16 11.3 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) PSI_integrin PF17205.3 EMC80968.1 - 0.69 9.7 9.5 1.2 8.9 9.5 1.4 1 0 0 1 1 1 0 Integrin plexin domain EGF PF00008.27 EMC80969.1 - 0.049 13.9 5.3 0.087 13.2 5.3 1.4 1 0 0 1 1 1 0 EGF-like domain Amnionless PF14828.6 EMC80969.1 - 0.12 11.2 0.0 0.18 10.6 0.0 1.3 1 0 0 1 1 1 0 Amnionless EGF_2 PF07974.13 EMC80969.1 - 0.17 12.3 9.5 0.3 11.5 9.5 1.4 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 EMC80969.1 - 4.3 8.1 6.5 0.67 10.7 2.4 1.8 2 0 0 2 2 2 0 Human growth factor-like EGF MAM PF00629.23 EMC80970.1 - 5.2e-21 75.2 1.4 5.8e-21 75.1 1.4 1.0 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu MAM PF00629.23 EMC80971.1 - 8.5e-43 146.0 0.0 9.4e-43 145.9 0.0 1.0 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu MAM PF00629.23 EMC80972.1 - 1.3e-68 229.9 0.2 1.1e-35 122.9 0.1 2.0 2 0 0 2 2 2 2 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.18 EMC80972.1 - 1.6e-09 37.8 9.4 1.6e-09 37.8 9.4 2.0 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A MAM PF00629.23 EMC80973.1 - 3.4e-24 85.6 0.6 3.8e-24 85.4 0.6 1.0 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu Arf PF00025.21 EMC80974.1 - 3.3e-65 218.8 0.1 3.7e-65 218.6 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EMC80974.1 - 5.1e-16 59.0 0.2 6.6e-16 58.6 0.2 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMC80974.1 - 3e-14 53.0 0.1 3.1e-14 52.9 0.1 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EMC80974.1 - 4.7e-13 49.0 0.1 5.6e-13 48.7 0.1 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EMC80974.1 - 4.9e-09 35.8 0.4 3e-06 26.6 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 EMC80974.1 - 2.4e-07 30.8 0.1 3.3e-07 30.4 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMC80974.1 - 4.3e-07 29.5 0.2 5e-07 29.3 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EMC80974.1 - 0.0021 17.6 0.1 0.03 13.9 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_14 PF13173.6 EMC80974.1 - 0.011 15.7 0.2 0.043 13.8 0.0 1.8 1 1 1 2 2 2 0 AAA domain FeoB_N PF02421.18 EMC80974.1 - 0.081 12.4 0.7 0.32 10.5 0.7 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B Methyltr_RsmB-F PF01189.17 EMC80975.1 - 1.1e-46 159.1 0.0 1.7e-46 158.4 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.6 EMC80975.1 - 4.6e-09 36.2 0.0 8.4e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EMC80975.1 - 7.2e-09 36.0 0.0 1.5e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF2431 PF10354.9 EMC80975.1 - 0.00023 21.5 0.0 0.00043 20.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) PUA PF01472.20 EMC80975.1 - 0.00031 20.6 0.1 0.00067 19.6 0.1 1.5 1 0 0 1 1 1 1 PUA domain Methyltransf_25 PF13649.6 EMC80975.1 - 0.00035 21.2 0.1 0.0047 17.6 0.1 2.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 EMC80975.1 - 0.0019 17.8 0.0 0.0035 16.9 0.0 1.5 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PCMT PF01135.19 EMC80975.1 - 0.004 16.9 0.0 0.0088 15.8 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 EMC80975.1 - 0.012 15.0 0.0 0.049 13.0 0.0 1.8 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Cons_hypoth95 PF03602.15 EMC80975.1 - 0.019 14.6 0.0 0.038 13.6 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 EMC80975.1 - 0.021 15.5 0.0 0.14 12.8 0.0 2.3 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 EMC80975.1 - 0.073 12.5 0.0 0.48 9.9 0.0 2.1 2 0 0 2 2 2 0 Putative methyltransferase TehB PF03848.14 EMC80975.1 - 0.14 11.6 0.0 0.32 10.4 0.0 1.6 1 0 0 1 1 1 0 Tellurite resistance protein TehB Guanylate_kin PF00625.21 EMC80976.1 - 2.5e-50 170.7 0.2 6.8e-50 169.3 0.2 1.8 1 0 0 1 1 1 1 Guanylate kinase VGCC_beta4Aa_N PF12052.8 EMC80976.1 - 5.4e-23 80.8 6.6 5.4e-23 80.8 6.6 3.1 3 0 0 3 3 3 1 Voltage gated calcium channel subunit beta domain 4Aa N terminal SH3_1 PF00018.28 EMC80976.1 - 0.0016 18.0 0.1 0.0064 16.1 0.1 2.0 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EMC80976.1 - 0.15 11.7 0.0 0.37 10.5 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain Zip PF02535.22 EMC80977.1 - 5.6e-64 216.5 12.3 8.3e-64 215.9 12.3 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter ZIP4_domain PF18292.1 EMC80977.1 - 8.9e-61 204.6 4.2 7.6e-56 188.6 1.9 2.4 2 0 0 2 2 2 2 Zinc transporter ZIP4 domain Lectin_C PF00059.21 EMC80978.1 - 0.0013 19.5 0.0 0.0021 18.8 0.0 1.4 1 1 0 1 1 1 1 Lectin C-type domain 7tm_3 PF00003.22 EMC80979.1 - 1.5e-61 208.1 16.0 2.1e-61 207.7 16.0 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.28 EMC80979.1 - 4.1e-45 154.4 0.0 5.5e-45 154.0 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.14 EMC80979.1 - 5.8e-13 48.6 11.4 1.2e-12 47.6 11.4 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR POT1PC PF16686.5 EMC80980.1 - 2.5e-39 134.6 0.0 4.9e-38 130.4 0.0 2.8 3 0 0 3 3 3 1 ssDNA-binding domain of telomere protection protein POT1 PF02765.17 EMC80980.1 - 3.2e-35 121.1 0.0 9.5e-35 119.5 0.0 1.9 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 tRNA_anti-codon PF01336.25 EMC80980.1 - 0.00051 20.0 0.2 10 6.2 0.0 4.4 3 1 1 4 4 4 2 OB-fold nucleic acid binding domain REPA_OB_2 PF16900.5 EMC80980.1 - 0.0011 18.8 0.0 0.0039 17.1 0.0 1.9 2 0 0 2 2 2 1 Replication protein A OB domain Keratin PF02422.16 EMC80981.1 - 1.9e-39 133.2 15.2 2.2e-39 133.0 15.2 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC80983.1 - 5.4e-40 135.0 13.7 6.3e-40 134.8 13.7 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC80984.1 - 2.2e-40 136.2 12.7 2.5e-40 136.1 12.7 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC80985.1 - 2e-41 139.6 14.6 2.2e-41 139.4 14.6 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC80986.1 - 2.8e-35 119.9 11.7 3.2e-35 119.7 11.7 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC80987.1 - 1e-40 137.3 15.7 1.2e-40 137.1 15.7 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC80989.1 - 2.1e-40 136.3 14.8 2.4e-40 136.1 14.8 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC80990.1 - 1.2e-40 137.1 14.9 1.3e-40 137.0 14.9 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC80991.1 - 5.1e-35 119.1 20.5 6.3e-35 118.8 20.5 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC80992.1 - 8e-37 124.8 21.4 9.8e-37 124.6 21.4 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC80994.1 - 1.2e-34 117.9 19.9 1.4e-34 117.7 19.9 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC80995.1 - 5.5e-35 118.9 18.8 6.8e-35 118.7 18.8 1.1 1 0 0 1 1 1 1 Keratin Stanniocalcin PF03298.13 EMC80995.1 - 0.0034 16.7 2.4 0.0045 16.3 2.4 1.1 1 0 0 1 1 1 1 Stanniocalcin family Keratin PF02422.16 EMC80996.1 - 1.3e-39 133.8 18.1 1.6e-39 133.5 18.1 1.1 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC80997.1 - 6.3e-40 134.8 18.1 7.8e-40 134.5 18.1 1.1 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC80998.1 - 2e-39 133.1 16.1 2.3e-39 133.0 16.1 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC80999.1 - 8.7e-39 131.1 17.0 1.1e-38 130.8 17.0 1.1 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC81000.1 - 4.7e-39 132.0 16.9 6e-39 131.6 16.9 1.1 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC81001.1 - 6.4e-39 131.6 18.2 7.9e-39 131.3 18.2 1.1 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC81002.1 - 1.9e-39 133.2 18.9 2.4e-39 132.9 18.9 1.1 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC81003.1 - 5.6e-38 128.5 19.0 6.9e-38 128.3 19.0 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC81004.1 - 8.2e-39 131.2 18.6 1e-38 130.9 18.6 1.1 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC81005.1 - 2.5e-39 132.8 17.7 3.2e-39 132.5 17.7 1.1 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC81006.1 - 1.3e-39 133.8 18.2 1.6e-39 133.5 18.2 1.1 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC81007.1 - 1.3e-34 117.7 9.2 1.5e-34 117.5 9.2 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC81008.1 - 1.3e-40 137.0 18.2 1.6e-40 136.7 18.2 1.1 1 0 0 1 1 1 1 Keratin Choline_kinase PF01633.20 EMC81009.1 - 3e-62 210.0 0.1 4.8e-62 209.3 0.1 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EMC81009.1 - 8.8e-14 52.0 0.0 1.8e-13 51.0 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EMC81009.1 - 0.0002 20.8 0.4 0.00031 20.1 0.1 1.4 2 0 0 2 2 2 1 Ecdysteroid kinase Cast PF10174.9 EMC81010.1 - 5.9e-28 97.6 6.5 6.5e-28 97.4 6.5 1.0 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone SecD-TM1 PF13721.6 EMC81010.1 - 0.0076 16.7 0.6 0.0087 16.5 0.6 1.1 1 0 0 1 1 1 1 SecD export protein N-terminal TM region MAD PF05557.13 EMC81010.1 - 0.036 12.4 5.4 0.044 12.2 5.4 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein FlaC_arch PF05377.11 EMC81010.1 - 4.3 7.8 6.8 5.1 7.6 0.9 2.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Glyco_hydro_47 PF01532.20 EMC81011.1 - 5e-105 352.1 0.0 9e-105 351.2 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 DUF2063 PF09836.9 EMC81011.1 - 0.12 12.6 0.0 1.2 9.4 0.0 2.3 2 0 0 2 2 2 0 Putative DNA-binding domain Arf PF00025.21 EMC81013.1 - 1.4e-39 135.4 0.1 1.6e-39 135.1 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EMC81013.1 - 4.2e-16 59.0 0.0 4.6e-16 58.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC81013.1 - 1.2e-11 44.9 0.0 2.1e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EMC81013.1 - 3.5e-07 29.8 0.0 4.2e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EMC81013.1 - 1.2e-05 24.7 0.1 1.7e-05 24.2 0.1 1.4 1 1 0 1 1 1 1 G-protein alpha subunit SRPRB PF09439.10 EMC81013.1 - 0.0014 18.1 0.0 0.0016 17.9 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EMC81013.1 - 0.013 15.6 0.0 0.026 14.6 0.0 1.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase HLH PF00010.26 EMC81014.1 - 5.8e-13 48.6 1.3 1.3e-12 47.4 1.3 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 EMC81014.1 - 6.1e-11 42.4 0.3 1.4e-10 41.1 0.3 1.7 1 0 0 1 1 1 1 Hairy Orange FGE-sulfatase PF03781.16 EMC81015.1 - 8e-89 297.7 7.2 9e-89 297.5 7.2 1.0 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 SET PF00856.28 EMC81016.1 - 3.2e-21 76.5 0.1 2.8e-19 70.1 0.1 2.3 1 1 0 1 1 1 1 SET domain Pre-SET PF05033.16 EMC81016.1 - 6e-06 26.9 15.8 7.2e-06 26.6 13.0 2.1 2 0 0 2 2 2 1 Pre-SET motif AWS PF17907.1 EMC81016.1 - 0.0018 18.3 3.9 0.0018 18.3 3.9 2.9 3 0 0 3 3 3 1 AWS domain LRR_8 PF13855.6 EMC81017.1 - 6.2e-51 170.0 67.9 2e-13 49.8 3.2 5.9 1 1 6 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 EMC81017.1 - 1e-24 86.2 47.1 3.2e-06 27.4 1.7 8.7 5 2 3 9 9 9 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC81017.1 - 1.2e-24 86.7 0.7 1.9e-11 44.0 3.3 3.7 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) I-set PF07679.16 EMC81017.1 - 1.2e-15 57.4 0.2 7.1e-15 54.8 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin I-set domain LRR_9 PF14580.6 EMC81017.1 - 4.1e-13 49.2 24.9 0.00023 20.7 3.3 4.4 1 1 3 4 4 4 4 Leucine-rich repeat Ig_3 PF13927.6 EMC81017.1 - 8.3e-13 48.8 0.2 2.8e-12 47.1 0.0 2.0 2 0 0 2 2 1 1 Immunoglobulin domain ig PF00047.25 EMC81017.1 - 1.1e-07 31.9 0.2 1.1e-06 28.7 0.0 2.5 3 0 0 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.6 EMC81017.1 - 1.3e-07 31.9 0.1 1.1e-06 28.9 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 EMC81017.1 - 2.2e-05 24.6 0.2 0.001 19.2 0.0 3.2 2 1 0 2 2 2 1 Immunoglobulin V-set domain LRRCT PF01463.24 EMC81017.1 - 0.00016 21.9 0.1 0.00042 20.6 0.1 1.8 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain LRR_1 PF00560.33 EMC81017.1 - 0.00021 21.4 26.2 0.25 12.0 0.1 9.4 10 0 0 10 10 9 1 Leucine Rich Repeat LRRNT PF01462.18 EMC81017.1 - 0.00024 20.6 1.0 0.00024 20.6 1.0 2.2 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain fn3 PF00041.21 EMC81017.1 - 0.0016 18.8 1.5 0.0035 17.7 1.5 1.6 1 0 0 1 1 1 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 EMC81017.1 - 0.0028 18.2 1.9 0.011 16.3 1.9 2.0 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Ig_6 PF18452.1 EMC81017.1 - 0.013 15.0 0.0 0.11 12.1 0.0 2.5 2 0 0 2 2 2 0 Immunoglobulin domain LRR_6 PF13516.6 EMC81017.1 - 0.052 13.6 16.7 17 5.8 0.1 6.8 4 1 1 5 5 5 0 Leucine Rich repeat Ig_5 PF16681.5 EMC81017.1 - 0.057 13.8 0.0 0.23 11.9 0.0 2.0 1 0 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain LON_substr_bdg PF02190.16 EMC81018.1 - 6.6e-25 88.2 0.0 8.4e-25 87.9 0.0 1.1 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain Yippee-Mis18 PF03226.14 EMC81018.1 - 1.2e-11 44.8 0.1 2.3e-11 43.8 0.1 1.5 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Baculo_ME53 PF06061.11 EMC81018.1 - 0.14 11.4 2.3 0.24 10.6 2.3 1.3 1 0 0 1 1 1 0 Baculoviridae ME53 Basic PF01586.16 EMC81019.1 - 3.2e-24 85.9 0.0 6e-24 85.0 0.0 1.5 1 0 0 1 1 1 1 Myogenic Basic domain HLH PF00010.26 EMC81019.1 - 2.4e-13 49.8 6.2 3.9e-13 49.1 6.2 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Basic PF01586.16 EMC81020.1 - 5e-24 85.3 1.3 5e-24 85.3 1.3 1.7 2 1 0 2 2 2 1 Myogenic Basic domain HLH PF00010.26 EMC81020.1 - 1.3e-14 53.9 4.6 1.8e-14 53.4 4.6 1.2 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Myf5 PF12232.8 EMC81020.1 - 7.1e-07 29.9 4.3 7.1e-07 29.9 4.3 2.0 2 0 0 2 2 2 1 Myogenic determination factor 5 HTH_51 PF18558.1 EMC81020.1 - 0.084 12.8 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain PDZ PF00595.24 EMC81021.1 - 7.6e-21 74.3 0.4 1.4e-20 73.4 0.4 1.4 1 0 0 1 1 1 1 PDZ domain L27 PF02828.16 EMC81021.1 - 1.2e-14 53.8 0.1 2.8e-14 52.6 0.0 1.7 2 0 0 2 2 2 1 L27 domain PDZ_6 PF17820.1 EMC81021.1 - 1.2e-13 50.6 0.3 3.7e-13 49.1 0.1 1.9 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 EMC81021.1 - 0.00069 19.9 0.0 0.0016 18.7 0.0 1.6 1 0 0 1 1 1 1 PDZ domain DUF932 PF06067.11 EMC81021.1 - 0.13 12.0 3.4 0.19 11.5 2.7 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF932) CREPT PF16566.5 EMC81021.1 - 0.15 12.2 6.5 0.21 11.7 5.1 1.8 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour AAA_lid_9 PF17871.1 EMC81021.1 - 0.34 10.9 4.2 0.28 11.1 2.1 1.9 2 0 0 2 2 2 0 AAA lid domain 7TMR-HDED PF07697.11 EMC81021.1 - 0.42 10.7 6.5 0.31 11.1 5.0 1.4 2 0 0 2 2 2 0 7TM-HD extracellular HGTP_anticodon PF03129.20 EMC81023.1 - 1.2e-23 83.0 0.0 4.6e-23 81.2 0.0 2.1 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EMC81023.1 - 4.2e-10 39.9 0.3 1.5e-09 38.1 0.1 2.2 3 1 0 3 3 3 1 tRNA synthetase class II core domain (G, H, P, S and T) WHEP-TRS PF00458.20 EMC81023.1 - 2.3e-08 34.1 4.8 7.9e-08 32.3 4.8 2.0 1 0 0 1 1 1 1 WHEP-TRS domain OS-D PF03392.13 EMC81023.1 - 0.028 14.5 0.1 0.092 12.9 0.1 1.8 1 0 0 1 1 1 0 Insect pheromone-binding family, A10/OS-D EcoRII-C PF09019.11 EMC81023.1 - 0.051 13.7 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 EcoRII C terminal zf-C2H2 PF00096.26 EMC81024.1 - 3.6e-69 225.6 112.5 6.4e-08 32.6 1.5 13.1 13 0 0 13 13 13 13 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC81024.1 - 4.2e-53 175.5 104.1 1.5e-09 37.8 0.7 15.0 14 1 0 14 14 14 11 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC81024.1 - 2.9e-43 142.8 104.2 0.0002 21.9 0.7 13.2 13 0 0 13 13 13 12 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EMC81024.1 - 3.8e-12 45.7 76.2 0.0005 19.8 0.5 12.4 13 0 0 13 13 13 6 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 EMC81024.1 - 5.3e-11 42.5 37.4 1.1 9.6 0.2 11.2 11 0 0 11 11 11 5 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 EMC81024.1 - 8.7e-11 42.0 50.2 0.0013 19.0 1.9 6.7 1 1 6 7 7 7 6 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 EMC81024.1 - 8.8e-11 41.5 101.6 0.0052 16.7 0.2 14.5 13 2 0 13 13 13 8 C2H2-type zinc finger C1_4 PF07975.12 EMC81024.1 - 1.7e-05 24.9 52.0 0.0013 18.9 1.8 7.2 3 2 3 7 7 7 4 TFIIH C1-like domain zf_UBZ PF18439.1 EMC81024.1 - 2.4e-05 23.8 67.2 1.3 8.7 0.1 12.7 13 0 0 13 13 13 7 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 EMC81024.1 - 0.00061 19.9 3.5 0.00061 19.9 3.5 9.4 4 3 8 12 12 11 5 Zinc ribbon domain ADK_lid PF05191.14 EMC81024.1 - 0.013 15.4 50.5 0.045 13.7 1.4 8.9 5 4 2 7 7 7 0 Adenylate kinase, active site lid zf-H2C2_5 PF13909.6 EMC81024.1 - 0.025 14.3 1.3 0.025 14.3 1.3 11.7 12 0 0 12 12 12 0 C2H2-type zinc-finger domain LIM PF00412.22 EMC81024.1 - 0.044 14.0 0.7 0.044 14.0 0.7 10.1 3 2 8 11 11 10 0 LIM domain GAGA PF09237.11 EMC81024.1 - 0.29 11.0 26.8 1.7 8.5 0.8 7.1 5 1 3 8 8 8 0 GAGA factor Chordopox_RPO7 PF05864.12 EMC81024.1 - 0.57 10.5 0.0 0.57 10.5 0.0 6.4 9 1 1 10 10 8 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) zinc_ribbon_15 PF17032.5 EMC81024.1 - 0.76 10.6 55.5 0.61 10.9 3.4 7.0 2 2 5 7 7 7 0 zinc-ribbon family zf-met PF12874.7 EMC81024.1 - 1.1 9.8 69.5 1.8 9.1 0.6 11.0 11 1 0 11 11 10 0 Zinc-finger of C2H2 type BolA PF01722.18 EMC81024.1 - 3.2 8.1 17.1 8.3 6.8 0.2 5.9 4 1 3 7 7 7 0 BolA-like protein 7tm_2 PF00002.24 EMC81025.1 - 2e-71 240.1 26.5 4.8e-69 232.4 18.4 2.1 2 0 0 2 2 2 2 7 transmembrane receptor (Secretin family) HRM PF02793.22 EMC81025.1 - 0.035 14.4 0.2 0.089 13.1 0.2 1.8 1 0 0 1 1 1 0 Hormone receptor domain TLV_coat PF00429.19 EMC81026.1 - 1.1e-07 31.0 0.7 1.2e-07 30.8 0.7 1.0 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) GP41 PF00517.17 EMC81026.1 - 0.00013 22.0 0.1 0.00016 21.7 0.1 1.1 1 0 0 1 1 1 1 Retroviral envelope protein CorA PF01544.18 EMC81026.1 - 0.01 15.2 0.0 0.01 15.2 0.0 1.5 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein IBN_N PF03810.19 EMC81028.1 - 6.4e-20 70.8 0.9 4e-19 68.3 0.0 2.8 3 0 0 3 3 3 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 EMC81028.1 - 0.011 16.1 0.1 0.29 11.5 0.0 2.9 3 0 0 3 3 3 0 HEAT repeats Xpo1 PF08389.12 EMC81028.1 - 0.052 13.6 0.0 0.052 13.6 0.0 4.9 5 0 0 5 5 5 0 Exportin 1-like protein HEAT PF02985.22 EMC81028.1 - 0.089 13.1 0.1 36 5.0 0.0 4.3 4 0 0 4 4 4 0 HEAT repeat RrnaAD PF00398.20 EMC81029.1 - 2e-62 210.7 0.0 2.3e-62 210.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EMC81029.1 - 8.2e-08 32.8 0.0 8.3e-07 29.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 EMC81029.1 - 0.0002 21.2 0.1 0.00036 20.3 0.1 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_11 PF08241.12 EMC81029.1 - 0.0004 21.0 0.0 0.0014 19.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC81029.1 - 0.00056 19.8 0.0 0.00081 19.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC81029.1 - 0.0017 19.0 0.0 0.0041 17.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EMC81029.1 - 0.0049 16.8 0.0 0.0094 15.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC81029.1 - 0.0089 15.8 0.0 0.037 13.8 0.0 1.8 1 1 0 2 2 2 1 Methyltransferase domain DREV PF05219.12 EMC81029.1 - 0.021 13.9 0.0 0.036 13.2 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_2 PF00891.18 EMC81029.1 - 0.031 13.6 0.0 0.047 13.0 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain Ubie_methyltran PF01209.18 EMC81029.1 - 0.033 13.5 0.0 0.057 12.7 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family MTS PF05175.14 EMC81029.1 - 0.036 13.6 0.0 0.06 12.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_4 PF02390.17 EMC81029.1 - 0.047 13.2 0.0 0.083 12.3 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Met_10 PF02475.16 EMC81029.1 - 0.079 12.7 0.1 0.19 11.5 0.0 1.6 2 0 0 2 2 2 0 Met-10+ like-protein UPF0020 PF01170.18 EMC81029.1 - 0.083 12.6 0.0 0.2 11.3 0.0 1.6 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 CMAS PF02353.20 EMC81029.1 - 0.12 11.7 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Kinesin PF00225.23 EMC81030.1 - 4.2e-93 311.9 0.1 1.1e-92 310.5 0.1 1.7 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EMC81030.1 - 1.5e-14 54.2 0.2 7e-14 52.0 0.0 2.1 2 0 0 2 2 2 1 Microtubule binding UPF0242 PF06785.11 EMC81030.1 - 0.59 10.2 13.3 0.23 11.6 7.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus CREPT PF16566.5 EMC81030.1 - 3.8 7.7 9.3 0.57 10.4 2.3 2.8 2 1 1 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour UPF0542 PF15086.6 EMC81031.1 - 3.3e-32 110.2 2.2 3.7e-32 110.1 2.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0542 TMEM100 PF16311.5 EMC81031.1 - 0.12 11.9 0.1 0.16 11.6 0.1 1.2 1 0 0 1 1 1 0 Transmembrane protein 100 NDUFA12 PF05071.16 EMC81032.1 - 0.0001 23.1 2.5 0.00016 22.5 2.5 1.6 1 1 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 WD40 PF00400.32 EMC81033.1 - 3.8e-23 81.3 11.3 5.5e-07 30.2 0.1 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC81033.1 - 2e-09 37.7 0.1 0.0015 18.8 0.1 4.3 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMC81033.1 - 0.00049 18.9 1.5 0.34 9.5 0.1 2.9 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 EMC81033.1 - 0.11 11.0 0.3 0.84 8.1 0.3 2.3 1 1 0 1 1 1 0 Cytochrome D1 heme domain eIF2A PF08662.11 EMC81033.1 - 0.14 12.0 0.1 2.2 8.1 0.0 2.7 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A ELO PF01151.18 EMC81034.1 - 3.2e-63 213.6 26.1 3.7e-63 213.4 26.1 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family DEP PF00610.21 EMC81035.1 - 1e-15 57.5 0.7 8e-15 54.7 0.1 2.6 3 0 0 3 3 3 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RhoGAP PF00620.27 EMC81035.1 - 0.073 12.9 0.1 0.4 10.5 0.0 2.3 2 0 0 2 2 2 0 RhoGAP domain Ras PF00071.22 EMC81037.1 - 3.4e-61 205.6 2.2 4e-61 205.3 2.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC81037.1 - 1.7e-33 115.4 1.1 2.6e-33 114.8 1.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC81037.1 - 4e-14 52.4 0.3 5.4e-14 52.0 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EMC81037.1 - 5.6e-07 29.2 0.7 0.0002 20.9 0.1 2.1 1 1 1 2 2 2 2 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EMC81037.1 - 0.00015 21.8 0.1 0.00027 21.0 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMC81037.1 - 0.00016 21.1 0.4 0.00023 20.6 0.4 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EMC81037.1 - 0.00019 21.0 0.1 0.00064 19.3 0.1 1.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain DUF2757 PF10955.8 EMC81037.1 - 0.0021 18.3 0.1 0.0043 17.3 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2757) FeoB_N PF02421.18 EMC81037.1 - 0.0034 16.9 0.0 2.7 7.5 0.0 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EMC81037.1 - 0.0095 15.8 0.1 0.94 9.4 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase Septin PF00735.18 EMC81037.1 - 0.012 14.9 0.2 0.44 9.8 0.0 2.2 2 0 0 2 2 2 0 Septin AAA_16 PF13191.6 EMC81037.1 - 0.073 13.4 0.0 0.17 12.3 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 EMC81037.1 - 0.17 11.0 3.1 6.7 5.8 0.0 3.1 1 1 1 2 2 2 0 G-protein alpha subunit Pkinase PF00069.25 EMC81038.1 - 6.5e-72 242.1 0.0 9.8e-72 241.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81038.1 - 6.5e-39 133.8 0.0 1.1e-38 133.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 EMC81038.1 - 8.7e-35 118.7 1.2 2.4e-16 59.7 0.4 2.6 2 0 0 2 2 2 2 POLO box duplicated region Pkinase_fungal PF17667.1 EMC81038.1 - 6.4e-06 25.2 0.7 8.1e-06 24.9 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EMC81038.1 - 2.6e-05 23.7 0.0 0.0011 18.3 0.0 2.2 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 EMC81038.1 - 0.09 12.7 1.0 6.6 6.6 0.1 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family ELM2 PF01448.24 EMC81039.1 - 2.8e-11 44.0 0.1 8.5e-11 42.4 0.1 1.8 1 0 0 1 1 1 1 ELM2 domain Myb_DNA-binding PF00249.31 EMC81039.1 - 5e-06 26.6 0.1 1.1e-05 25.5 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EMC81039.1 - 0.0044 16.9 0.0 0.012 15.4 0.0 1.7 1 0 0 1 1 1 1 Myb DNA-binding like DUF2095 PF09868.9 EMC81039.1 - 0.11 12.5 2.8 2.6 8.0 0.5 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2095) SET PF00856.28 EMC81040.1 - 2.7e-05 24.6 0.1 6e-05 23.5 0.1 1.7 1 1 0 1 1 1 1 SET domain Fer4_23 PF18009.1 EMC81041.1 - 0.26 11.7 4.4 11 6.6 1.5 2.8 2 1 0 2 2 2 0 4Fe-4S iron-sulfur cluster binding domain C8 PF08742.11 EMC81041.1 - 1 9.8 7.1 11 6.6 0.3 2.4 2 0 0 2 2 2 0 C8 domain Guanylate_cyc PF00211.20 EMC81042.1 - 8.7e-38 129.8 0.0 5.2e-36 124.0 0.0 2.1 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 EMC81042.1 - 1.5e-05 24.5 0.9 2.2e-05 24.0 0.9 1.2 1 0 0 1 1 1 1 Heme NO binding associated Pkinase_Tyr PF07714.17 EMC81042.1 - 0.0012 18.2 0.0 0.0024 17.2 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase DIRP PF06584.13 EMC81042.1 - 0.014 15.6 0.5 0.024 14.8 0.5 1.3 1 0 0 1 1 1 0 DIRP CHASE6_C PF17150.4 EMC81042.1 - 0.027 15.1 0.2 0.045 14.4 0.2 1.4 1 0 0 1 1 1 0 C-terminal domain of two-partite extracellular sensor domain dsDNA_bind PF01984.20 EMC81042.1 - 0.035 14.4 0.1 0.073 13.3 0.1 1.4 1 1 0 1 1 1 0 Double-stranded DNA-binding domain YtxC PF08812.11 EMC81042.1 - 0.045 13.4 0.2 0.063 12.9 0.2 1.2 1 0 0 1 1 1 0 YtxC-like family CARD PF00619.21 EMC81042.1 - 0.085 12.9 1.1 0.16 12.0 0.4 1.8 2 0 0 2 2 2 0 Caspase recruitment domain Ints3 PF10189.9 EMC81043.1 - 7.2e-73 244.6 0.8 7.2e-73 244.6 0.8 1.6 2 0 0 2 2 2 1 Integrator complex subunit 3 Aconitase_B_N PF11791.8 EMC81043.1 - 0.13 12.3 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 Aconitate B N-terminal domain Ras PF00071.22 EMC81044.1 - 4.8e-40 136.8 0.0 7.6e-40 136.2 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC81044.1 - 5.4e-14 52.4 0.0 9.7e-14 51.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC81044.1 - 5.2e-08 32.5 0.0 7.1e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC81044.1 - 0.00091 19.3 0.0 0.0016 18.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC81044.1 - 0.003 17.1 0.0 0.01 15.4 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EMC81044.1 - 0.032 13.7 0.0 0.091 12.2 0.0 1.7 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit TniB PF05621.11 EMC81044.1 - 0.051 13.0 0.1 0.28 10.6 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein AAA_16 PF13191.6 EMC81044.1 - 0.099 13.0 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 EMC81044.1 - 0.16 11.9 0.1 2.4 8.0 0.0 2.3 2 1 0 2 2 2 0 RsgA GTPase Globin PF00042.22 EMC81045.1 - 2.1e-24 86.2 0.1 3.9e-24 85.3 0.1 1.4 1 0 0 1 1 1 1 Globin AbiJ_NTD5 PF18865.1 EMC81045.1 - 0.008 16.0 0.0 0.033 14.0 0.0 2.0 1 1 1 2 2 2 1 AbiJ N-terminal domain 5 Fox-1_C PF12414.8 EMC81046.1 - 3.2e-42 142.8 27.4 6.6e-42 141.8 23.9 2.8 2 0 0 2 2 2 1 Calcitonin gene-related peptide regulator C terminal RRM_1 PF00076.22 EMC81046.1 - 3.1e-18 65.3 0.1 3.1e-18 65.3 0.1 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMC81046.1 - 0.057 13.0 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Thioredoxin PF00085.20 EMC81047.1 - 3.3e-28 97.7 0.1 4.1e-28 97.4 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EMC81047.1 - 4.2e-08 33.6 0.1 5.9e-07 29.9 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 EMC81047.1 - 1.4e-05 25.2 0.0 2.3e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_3 PF13192.6 EMC81047.1 - 0.00049 20.1 0.1 0.00071 19.6 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_8 PF13905.6 EMC81047.1 - 0.00082 19.7 0.0 0.056 13.8 0.0 2.3 1 1 1 2 2 2 1 Thioredoxin-like AhpC-TSA PF00578.21 EMC81047.1 - 0.005 16.8 0.0 0.0066 16.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family DSBA PF01323.20 EMC81047.1 - 0.015 15.1 0.0 0.35 10.6 0.0 2.0 1 1 1 2 2 2 0 DSBA-like thioredoxin domain Thioredoxin_9 PF14595.6 EMC81047.1 - 0.022 14.5 0.0 0.03 14.1 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin DUF836 PF05768.14 EMC81047.1 - 0.19 12.2 0.0 0.27 11.6 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Ntox30 PF15532.6 EMC81047.1 - 0.2 12.1 0.0 0.31 11.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial toxin 30 Pyr_redox_3 PF13738.6 EMC81048.1 - 2.6e-34 118.9 0.0 8.8e-33 113.8 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMC81048.1 - 7.3e-10 38.6 0.0 1.5e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMC81048.1 - 5.3e-08 32.4 0.0 3.7e-06 26.3 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 EMC81048.1 - 2.7e-06 26.4 0.0 0.0016 17.2 0.0 2.1 2 0 0 2 2 2 2 HI0933-like protein NAD_binding_8 PF13450.6 EMC81048.1 - 5.1e-06 26.6 0.0 1.3e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FMO-like PF00743.19 EMC81048.1 - 1.4e-05 23.7 0.0 5.9e-05 21.7 0.0 1.9 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like DAO PF01266.24 EMC81048.1 - 1.5e-05 24.8 0.0 0.0017 18.0 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMC81048.1 - 0.00013 21.2 0.0 0.00032 19.9 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 EMC81048.1 - 0.00016 21.1 0.0 0.00025 20.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EMC81048.1 - 0.00057 19.2 0.0 0.0013 18.1 0.0 1.5 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EMC81048.1 - 0.00057 20.4 0.0 0.19 12.3 0.0 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EMC81048.1 - 0.015 14.6 0.0 0.33 10.2 0.0 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Peptidase_C71 PF12386.8 EMC81048.1 - 0.053 13.2 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Pseudomurein endo-isopeptidase Pei GIDA PF01134.22 EMC81048.1 - 0.088 11.9 0.0 0.82 8.7 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A YaiA PF16362.5 EMC81048.1 - 0.12 12.5 0.0 0.39 10.9 0.0 1.8 2 0 0 2 2 1 0 YaiA protein LigT_PEase PF02834.16 EMC81048.1 - 0.16 12.2 0.0 9.3 6.5 0.0 2.5 2 0 0 2 2 2 0 LigT like Phosphoesterase CYTH PF01928.21 EMC81048.1 - 0.17 11.8 0.0 0.3 11.0 0.0 1.3 1 0 0 1 1 1 0 CYTH domain NAD_binding_9 PF13454.6 EMC81048.1 - 0.18 11.8 0.5 1.1 9.2 0.5 2.3 1 1 0 1 1 1 0 FAD-NAD(P)-binding PMP22_Claudin PF00822.20 EMC81049.1 - 9.8e-58 194.7 1.8 1.3e-57 194.3 1.8 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC81049.1 - 3.1e-21 76.0 0.8 4.9e-21 75.4 0.8 1.4 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Ras PF00071.22 EMC81050.1 - 2.3e-35 121.6 0.0 2.6e-35 121.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC81050.1 - 9.8e-17 61.3 0.0 1.8e-16 60.5 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC81050.1 - 5.3e-05 22.7 0.0 6.1e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC81050.1 - 0.00032 20.3 0.0 0.00038 20.0 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EMC81050.1 - 0.0097 16.0 0.0 0.018 15.2 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC81050.1 - 0.023 14.6 0.0 0.1 12.5 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase EF-hand_1 PF00036.32 EMC81051.1 - 8.2e-10 37.5 3.9 1.9e-06 27.0 0.8 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EMC81051.1 - 4.3e-09 36.7 0.8 8.7e-09 35.7 0.5 1.6 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 EMC81051.1 - 1.7e-08 33.6 3.4 8.1e-05 21.9 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EMC81051.1 - 3.1e-08 32.9 2.5 1.8e-05 24.3 0.2 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 EMC81051.1 - 1e-05 25.3 2.7 0.028 14.3 0.2 2.8 1 1 1 2 2 2 2 EF-hand domain pair EFhand_Ca_insen PF08726.10 EMC81051.1 - 0.081 13.0 0.2 0.31 11.2 0.0 1.9 2 0 0 2 2 2 0 Ca2+ insensitive EF hand Skp1 PF01466.19 EMC81051.1 - 0.091 12.9 0.1 0.2 11.8 0.1 1.6 1 0 0 1 1 1 0 Skp1 family, dimerisation domain PSP1 PF04468.12 EMC81052.1 - 0.021 15.1 0.1 0.052 13.8 0.1 1.6 1 0 0 1 1 1 0 PSP1 C-terminal conserved region PX PF00787.24 EMC81053.1 - 1.4e-17 63.7 0.0 2.4e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 PX domain PB1 PF00564.24 EMC81053.1 - 1.4e-14 53.8 2.0 5.5e-14 51.9 1.0 2.2 2 0 0 2 2 2 1 PB1 domain SH3_1 PF00018.28 EMC81053.1 - 4.5e-12 45.4 0.1 1.1e-11 44.2 0.0 1.7 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EMC81053.1 - 4.1e-10 39.4 0.2 1.2e-09 37.9 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EMC81053.1 - 5.1e-09 35.7 0.0 2.4e-08 33.5 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain fn3 PF00041.21 EMC81054.1 - 1.6e-14 54.0 3.8 2.5e-08 34.2 0.0 4.7 4 2 1 5 5 5 3 Fibronectin type III domain IL6Ra-bind PF09240.10 EMC81054.1 - 3.1e-11 43.5 4.7 7.6e-07 29.5 0.1 2.8 2 1 0 2 2 2 2 Interleukin-6 receptor alpha chain, binding IL4Ra_N PF09238.10 EMC81054.1 - 8e-09 35.7 4.6 0.0016 18.7 0.6 3.0 3 1 1 4 4 4 2 Interleukin-4 receptor alpha chain, N-terminal EpoR_lig-bind PF09067.10 EMC81054.1 - 5.4e-05 23.3 5.3 0.002 18.3 0.0 2.8 3 0 0 3 3 3 2 Erythropoietin receptor, ligand binding Tissue_fac PF01108.17 EMC81054.1 - 0.0011 18.8 6.4 0.0037 17.1 0.0 3.4 3 1 1 4 4 4 1 Tissue factor IL2RB_N1 PF18707.1 EMC81054.1 - 0.0021 18.6 8.6 0.0088 16.6 0.5 3.5 3 1 0 3 3 3 1 Interleukin-2 receptor subunit beta N-terminal domain 1 IL12p40_C PF10420.9 EMC81054.1 - 0.061 13.8 6.7 0.21 12.1 0.6 3.1 3 1 0 3 3 3 0 Cytokine interleukin-12p40 C-terminus WAPL PF07814.13 EMC81054.1 - 0.15 10.8 0.4 0.24 10.1 0.0 1.5 2 0 0 2 2 2 0 Wings apart-like protein regulation of heterochromatin TTSSLRR PF12468.8 EMC81054.1 - 0.42 10.9 2.7 0.49 10.7 0.2 2.5 2 1 0 2 2 2 0 Type III secretion system leucine rich repeat protein Sugar_tr PF00083.24 EMC81055.1 - 7.5e-33 114.1 13.9 9.7e-33 113.7 13.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMC81055.1 - 7e-31 107.4 44.8 1.1e-26 93.6 25.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TB2_DP1_HVA22 PF03134.19 EMC81056.1 - 4e-27 94.0 10.1 6.1e-27 93.4 10.1 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family DUF2306 PF10067.9 EMC81056.1 - 0.056 13.6 0.6 0.1 12.8 0.6 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2306) PLAC9 PF15205.6 EMC81058.1 - 3.3e-15 56.2 0.1 3.5e-15 56.1 0.1 1.0 1 0 0 1 1 1 1 Placenta-specific protein 9 Annexin PF00191.20 EMC81059.1 - 1e-102 336.2 12.8 7.8e-26 89.9 0.3 4.1 4 0 0 4 4 4 4 Annexin Myb_DNA-bind_7 PF15963.5 EMC81059.1 - 0.034 14.0 0.4 17 5.4 0.0 3.1 3 0 0 3 3 3 0 Myb DNA-binding like PSP1 PF04468.12 EMC81061.1 - 0.021 15.1 0.1 0.052 13.8 0.1 1.6 1 0 0 1 1 1 0 PSP1 C-terminal conserved region Cadherin PF00028.17 EMC81062.1 - 3.8e-92 302.9 1.4 2.6e-23 82.3 0.1 6.0 6 0 0 6 6 6 5 Cadherin domain Cadherin_C PF01049.17 EMC81062.1 - 1.5e-53 181.0 0.4 2.9e-53 180.1 0.4 1.4 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_pro PF08758.11 EMC81062.1 - 3.9e-30 103.9 0.2 4e-29 100.6 0.1 2.4 2 0 0 2 2 2 1 Cadherin prodomain like Cadherin_3 PF16184.5 EMC81062.1 - 4e-07 30.0 6.8 0.035 14.1 0.1 4.8 4 0 0 4 4 4 2 Cadherin-like Cadherin_2 PF08266.12 EMC81062.1 - 7.3e-05 22.5 0.0 3.8 7.4 0.0 3.4 3 0 0 3 3 3 2 Cadherin-like He_PIG PF05345.12 EMC81062.1 - 0.0003 20.9 9.6 0.89 9.8 0.4 5.9 5 1 0 5 5 5 2 Putative Ig domain Prok-E2_A PF14457.6 EMC81062.1 - 0.0066 16.1 0.5 0.4 10.3 0.3 2.3 2 0 0 2 2 2 1 Prokaryotic E2 family A EphA2_TM PF14575.6 EMC81062.1 - 0.015 16.1 0.0 0.035 15.0 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Cadherin_4 PF17803.1 EMC81062.1 - 0.051 14.2 20.9 1.4 9.6 0.1 5.0 5 1 0 5 5 4 0 Bacterial cadherin-like domain DUF5385 PF17359.2 EMC81062.1 - 0.099 12.2 0.2 0.22 11.1 0.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5385) Stevor PF17410.2 EMC81062.1 - 0.12 11.9 0.1 0.18 11.3 0.1 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame DUF4381 PF14316.6 EMC81062.1 - 0.19 12.0 0.1 0.34 11.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Big_9 PF17963.1 EMC81062.1 - 6.7 7.5 24.1 0.49 11.2 0.2 5.3 5 1 1 6 6 6 0 Bacterial Ig domain Sulfotransfer_2 PF03567.14 EMC81064.1 - 2.8e-62 210.9 1.0 3.9e-62 210.4 1.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family MIP PF00230.20 EMC81065.1 - 1.8e-72 243.8 14.3 2.2e-72 243.4 14.3 1.0 1 0 0 1 1 1 1 Major intrinsic protein BTB_2 PF02214.22 EMC81066.1 - 2.5e-17 63.0 0.0 4e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain TAF4 PF05236.14 EMC81067.1 - 6.8e-52 176.9 8.9 1.2e-51 176.2 8.9 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family TAFH PF07531.14 EMC81067.1 - 3.1e-39 133.0 4.9 9.8e-39 131.4 4.9 2.0 1 0 0 1 1 1 1 NHR1 homology to TAF zf-C2H2_4 PF13894.6 EMC81069.1 - 2.5e-68 220.8 213.8 0.00037 21.1 0.8 31.2 31 0 0 31 31 31 26 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC81069.1 - 1.8e-49 163.5 219.5 0.0012 19.2 3.0 30.6 31 0 0 31 31 31 23 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EMC81069.1 - 7.3e-35 118.3 181.6 9e-08 31.9 0.1 26.5 26 1 1 27 27 26 16 C2H2-type zinc finger zf-Di19 PF05605.12 EMC81069.1 - 7.3e-22 77.4 168.6 6.5e-05 23.1 3.4 19.3 15 3 4 20 20 20 12 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 EMC81069.1 - 2.5e-19 68.7 189.5 6.7e-06 26.3 1.0 28.7 32 1 0 32 32 31 13 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EMC81069.1 - 7.7e-10 38.8 182.3 0.013 15.7 0.6 25.8 29 0 0 29 29 28 12 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EMC81069.1 - 4.2e-05 23.8 169.3 0.11 12.9 0.9 24.5 8 6 13 22 22 21 10 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 EMC81069.1 - 0.00014 22.1 14.1 0.0079 16.6 1.2 21.6 25 0 0 25 25 25 8 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 EMC81069.1 - 0.01 16.1 1.6 0.01 16.1 1.6 13.8 9 4 4 14 14 14 0 C2H2-type zinc ribbon zf-C2HC_2 PF13913.6 EMC81069.1 - 0.063 13.2 0.1 0.063 13.2 0.1 16.8 18 1 1 19 19 18 0 zinc-finger of a C2HC-type Zn-C2H2_12 PF18112.1 EMC81069.1 - 0.11 13.0 0.2 0.11 13.0 0.2 11.1 13 0 0 13 13 10 0 Autophagy receptor zinc finger-C2H2 domain 7tm_1 PF00001.21 EMC81071.1 - 6.6e-63 212.5 9.3 7.8e-63 212.3 9.3 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC81071.1 - 5.6e-07 29.2 14.0 0.0021 17.5 8.4 2.3 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC81071.1 - 0.0007 19.4 5.9 0.0007 19.4 5.9 1.5 2 0 0 2 2 2 1 Olfactory receptor 7tm_1 PF00001.21 EMC81072.1 - 1.2e-61 208.3 11.7 1.4e-61 208.1 11.7 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC81072.1 - 2e-07 30.6 14.0 0.00089 18.7 8.9 2.3 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC81072.1 - 0.00052 19.8 6.5 0.00052 19.8 6.5 1.4 2 0 0 2 2 2 1 Olfactory receptor UPF0029 PF01205.19 EMC81073.1 - 6.9e-35 119.6 0.0 1.1e-34 118.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 EMC81073.1 - 5.4e-17 62.1 0.8 1.5e-16 60.7 0.8 1.8 1 0 0 1 1 1 1 RWD domain Oxysterol_BP PF01237.18 EMC81074.1 - 1.8e-150 501.0 0.5 2.4e-150 500.5 0.5 1.2 1 0 0 1 1 1 1 Oxysterol-binding protein Ank PF00023.30 EMC81074.1 - 7e-24 83.2 3.7 5.5e-08 32.9 0.0 4.3 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EMC81074.1 - 1.1e-23 83.0 2.8 2.5e-09 37.2 0.1 3.9 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC81074.1 - 4.6e-22 78.4 1.3 2e-13 50.7 0.1 2.9 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC81074.1 - 2.3e-21 75.8 1.6 3.9e-05 24.1 0.0 5.4 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC81074.1 - 7.3e-16 56.7 0.6 5.1e-05 23.4 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat PH_11 PF15413.6 EMC81074.1 - 0.0045 17.4 0.2 0.0045 17.4 0.2 3.9 4 0 0 4 4 4 1 Pleckstrin homology domain PH PF00169.29 EMC81074.1 - 0.01 16.3 0.7 0.01 16.3 0.7 3.2 3 0 0 3 3 3 0 PH domain RIIa PF02197.17 EMC81075.1 - 1.9e-05 24.2 0.3 1.9e-05 24.2 0.3 2.2 3 0 0 3 3 3 1 Regulatory subunit of type II PKA R-subunit DUF3808 PF10300.9 EMC81077.1 - 1.7e-125 419.5 7.1 2e-125 419.2 7.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_2 PF07719.17 EMC81077.1 - 6.6e-06 25.8 1.4 0.39 10.9 0.1 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 EMC81077.1 - 0.00026 20.7 0.9 0.43 10.5 0.1 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EMC81077.1 - 0.0011 18.4 0.1 5.8 6.2 0.0 3.4 2 1 0 2 2 2 1 MalT-like TPR region TPR_6 PF13174.6 EMC81077.1 - 0.0028 18.2 0.3 25 5.8 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 EMC81077.1 - 0.0029 17.9 0.3 2.1 8.7 0.0 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat VEFS-Box PF09733.9 EMC81077.1 - 0.018 14.8 0.0 0.066 13.0 0.0 2.0 1 0 0 1 1 1 0 VEFS-Box of polycomb protein TPR_7 PF13176.6 EMC81077.1 - 0.023 14.7 0.9 0.25 11.5 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EMC81077.1 - 0.19 12.0 0.9 5.1 7.6 0.0 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat adh_short_C2 PF13561.6 EMC81078.1 - 6.2e-40 137.2 0.1 7.2e-40 137.0 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMC81078.1 - 1.1e-28 100.0 0.2 1.4e-28 99.7 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Pkinase PF00069.25 EMC81079.1 - 5e-66 222.8 0.0 6.5e-66 222.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81079.1 - 3.2e-39 134.8 0.0 4.6e-39 134.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.24 EMC81079.1 - 1e-12 47.8 0.2 2.1e-12 46.8 0.2 1.5 1 0 0 1 1 1 1 PB1 domain Kinase-like PF14531.6 EMC81079.1 - 7.1e-06 25.5 0.0 0.0016 17.8 0.0 2.3 2 0 0 2 2 2 2 Kinase-like FTA2 PF13095.6 EMC81079.1 - 0.033 13.8 0.0 0.059 13.0 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EMC81079.1 - 0.047 13.0 0.0 0.077 12.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EMC81079.1 - 0.049 12.7 0.0 1.4 7.9 0.0 2.1 2 0 0 2 2 2 0 Seadornavirus VP7 ERCC3_RAD25_C PF16203.5 EMC81080.1 - 1.2e-124 414.5 1.9 2e-124 413.7 1.9 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 EMC81080.1 - 1.3e-37 128.7 0.0 3.8e-37 127.3 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC81080.1 - 5.1e-16 59.2 0.0 1.4e-15 57.7 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EMC81080.1 - 1.6e-09 38.0 0.1 4.3e-09 36.7 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EMC81080.1 - 0.0016 17.3 0.0 0.0024 16.7 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF2605 PF10792.9 EMC81080.1 - 0.57 10.1 3.9 0.16 11.9 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2605) p450 PF00067.22 EMC81081.1 - 4.2e-101 339.0 0.0 4.7e-101 338.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 BAR PF03114.18 EMC81082.1 - 4.6e-46 157.4 12.1 6e-46 157.0 12.1 1.1 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.6 EMC81082.1 - 6.3e-12 45.2 0.2 2.8e-11 43.1 0.2 2.0 1 1 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC81082.1 - 4.1e-07 29.5 0.2 1.1e-06 28.1 0.2 1.8 1 1 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC81082.1 - 5e-06 26.1 0.0 1.2e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain BAR_3 PF16746.5 EMC81082.1 - 0.0018 18.0 12.5 0.0024 17.6 4.0 2.3 1 1 1 2 2 2 2 BAR domain of APPL family OmpH PF03938.14 EMC81082.1 - 0.007 16.7 10.6 0.034 14.5 0.4 2.3 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) Jnk-SapK_ap_N PF09744.9 EMC81082.1 - 0.02 15.1 1.5 0.02 15.1 1.5 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF3104 PF11302.8 EMC81082.1 - 0.087 12.6 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) BLOC1_2 PF10046.9 EMC81082.1 - 0.36 11.2 11.4 0.14 12.5 3.3 2.9 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Baculo_PEP_C PF04513.12 EMC81082.1 - 0.53 10.3 2.1 17 5.4 0.1 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus PTS_IIA PF02255.16 EMC81082.1 - 0.71 9.9 8.1 7.5 6.7 1.9 2.8 2 1 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIA subunit THP2 PF09432.10 EMC81082.1 - 0.91 9.6 5.3 0.17 12.0 0.8 1.9 2 0 0 2 2 2 0 Tho complex subunit THP2 Syndecan PF01034.20 EMC81083.1 - 0.00047 20.0 0.1 0.00066 19.5 0.1 1.3 1 0 0 1 1 1 1 Syndecan domain Protocadherin PF08374.11 EMC81083.1 - 0.0028 17.7 0.0 0.0028 17.7 0.0 1.1 1 0 0 1 1 1 1 Protocadherin Spore_SspJ PF09575.10 EMC81083.1 - 0.015 15.7 0.8 0.022 15.1 0.8 1.2 1 0 0 1 1 1 0 Small spore protein J (Spore_SspJ) EphA2_TM PF14575.6 EMC81083.1 - 0.024 15.5 0.0 0.028 15.3 0.0 1.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Chordopox_A13L PF05961.11 EMC81083.1 - 0.038 14.2 0.0 0.046 14.0 0.0 1.3 1 0 0 1 1 1 0 Chordopoxvirus A13L protein MAP17 PF15807.5 EMC81083.1 - 0.043 14.0 0.0 0.055 13.7 0.0 1.1 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Baculo_11_kDa PF06143.11 EMC81083.1 - 0.048 13.2 0.0 0.062 12.9 0.0 1.2 1 0 0 1 1 1 0 Baculovirus 11 kDa family OAD_gamma PF04277.13 EMC81083.1 - 0.069 13.7 0.1 0.11 13.1 0.1 1.4 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain ECSCR PF15820.5 EMC81083.1 - 0.1 12.5 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator DUF4692 PF15763.5 EMC81083.1 - 0.12 12.9 0.0 0.14 12.6 0.0 1.1 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) m04gp34like PF12216.8 EMC81083.1 - 0.12 12.0 0.1 0.13 11.8 0.1 1.1 1 0 0 1 1 1 0 Immune evasion protein Adeno_E3_CR2 PF02439.15 EMC81083.1 - 0.59 9.9 6.8 0.92 9.3 6.8 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 7tm_4 PF13853.6 EMC81084.1 - 3.6e-41 141.7 13.8 4.7e-41 141.3 13.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC81084.1 - 6.9e-22 78.0 12.1 1.1e-21 77.4 12.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) adh_short_C2 PF13561.6 EMC81085.1 - 3.7e-28 98.7 0.0 4.2e-28 98.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMC81085.1 - 9.6e-12 44.8 0.0 1.1e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Cu_amine_oxid PF01179.20 EMC81086.1 - 5.2e-108 361.6 0.0 6.4e-108 361.3 0.0 1.0 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain zf-H2C2_2 PF13465.6 EMC81087.1 - 3e-83 270.8 76.9 4.1e-10 39.6 0.5 11.1 11 0 0 11 11 11 10 Zinc-finger double domain zf-C2H2 PF00096.26 EMC81087.1 - 4.3e-68 222.2 84.9 1.8e-07 31.2 0.9 10.1 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC81087.1 - 1.1e-41 137.8 80.2 4e-05 24.1 1.0 10.1 10 0 0 10 10 10 10 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC81087.1 - 4.7e-25 87.3 34.5 8.1e-05 22.8 0.1 10.1 10 0 0 10 10 10 7 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMC81087.1 - 2.1e-15 56.3 82.0 2.6e-05 24.1 0.5 10.8 10 1 0 10 10 10 7 C2H2-type zinc finger zf-met PF12874.7 EMC81087.1 - 4.9e-15 55.4 61.0 0.00087 19.6 0.2 10.1 10 0 0 10 10 10 6 Zinc-finger of C2H2 type zf_UBZ PF18439.1 EMC81087.1 - 9.5e-15 53.9 40.3 0.13 11.9 0.4 10.2 10 0 0 10 10 10 6 Ubiquitin-Binding Zinc Finger zf-Di19 PF05605.12 EMC81087.1 - 3e-12 46.6 45.8 0.00014 22.1 1.1 6.5 4 2 0 5 5 5 4 Drought induced 19 protein (Di19), zinc-binding zf-LYAR PF08790.11 EMC81087.1 - 5.6e-10 38.9 50.9 0.032 14.1 0.2 10.1 10 0 0 10 10 10 5 LYAR-type C2HC zinc finger Zn-ribbon_8 PF09723.10 EMC81087.1 - 6.5e-10 39.0 44.4 0.0024 18.0 3.4 7.0 2 2 7 9 9 9 8 Zinc ribbon domain FYDLN_acid PF09538.10 EMC81087.1 - 4.7e-09 36.9 27.2 2.2 9.0 0.1 9.4 1 1 8 9 9 9 1 Protein of unknown function (FYDLN_acid) zinc_ribbon_15 PF17032.5 EMC81087.1 - 4.6e-08 33.7 27.2 0.16 12.7 0.3 5.1 2 1 3 5 5 5 4 zinc-ribbon family CpXC PF14353.6 EMC81087.1 - 6.1e-08 32.7 37.9 1.7 8.7 0.1 9.7 5 4 3 9 9 9 2 CpXC protein zf-AN1 PF01428.16 EMC81087.1 - 7.7e-08 32.4 55.4 2.3 8.4 0.1 10.2 8 1 2 10 10 10 2 AN1-like Zinc finger HypA PF01155.19 EMC81087.1 - 1.8e-06 27.9 28.5 0.14 12.2 0.3 5.6 1 1 5 6 6 6 3 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF3268 PF11672.8 EMC81087.1 - 2.3e-06 27.9 17.7 0.61 10.4 0.1 5.2 4 1 0 5 5 5 3 zinc-finger-containing domain LIM PF00412.22 EMC81087.1 - 1.9e-05 24.8 44.7 0.15 12.3 7.6 8.3 2 2 5 7 7 7 2 LIM domain zf-C2HE PF16278.5 EMC81087.1 - 5e-05 23.7 63.5 1.1 9.8 1.9 10.1 1 1 9 10 10 10 3 C2HE / C2H2 / C2HC zinc-binding finger zinc_ribbon_9 PF14369.6 EMC81087.1 - 0.00017 21.8 44.5 3 8.2 0.2 9.6 9 1 1 10 10 10 1 zinc-ribbon zinc-ribbons_6 PF07191.12 EMC81087.1 - 0.00048 20.0 37.5 7.8e+02 0.2 19.8 6.2 1 1 1 2 2 1 0 zinc-ribbons ADK_lid PF05191.14 EMC81087.1 - 0.0012 18.7 33.5 1.1 9.2 1.4 7.8 4 3 4 8 8 8 1 Adenylate kinase, active site lid zf_C2H2_ZHX PF18387.1 EMC81087.1 - 0.0026 17.3 52.7 1.9 8.2 0.2 9.7 1 1 9 10 10 10 3 Zinc-fingers and homeoboxes C2H2 finger domain Elf1 PF05129.13 EMC81087.1 - 0.003 17.6 41.7 0.3 11.2 0.8 7.1 1 1 4 5 5 5 2 Transcription elongation factor Elf1 like zf-C2H2_9 PF16293.5 EMC81087.1 - 0.0038 17.0 15.1 4.8 7.1 0.1 6.5 7 0 0 7 7 6 0 C2H2 type zinc-finger (1 copy) zf-trcl PF13451.6 EMC81087.1 - 0.0048 16.8 41.7 1.2 9.1 0.2 9.2 10 0 0 10 10 10 3 Probable zinc-ribbon domain MBD PF01429.19 EMC81087.1 - 0.013 15.2 0.6 3.3 7.5 0.6 3.6 1 1 0 1 1 1 0 Methyl-CpG binding domain Prok-RING_1 PF14446.6 EMC81087.1 - 0.04 13.9 33.5 4 7.4 0.0 9.1 7 3 1 8 8 8 0 Prokaryotic RING finger family 1 zf-H2C2_5 PF13909.6 EMC81087.1 - 0.057 13.2 0.0 0.057 13.2 0.0 10.8 10 2 0 10 10 8 0 C2H2-type zinc-finger domain HalOD2 PF18547.1 EMC81087.1 - 0.061 13.2 31.3 1.3 9.0 2.3 6.4 5 3 0 5 5 5 0 Halobacterial output domain 2 YhfH PF14149.6 EMC81087.1 - 0.085 12.9 39.8 8.5 6.5 0.2 9.0 10 0 0 10 10 9 0 YhfH-like protein Zn_Tnp_IS1595 PF12760.7 EMC81087.1 - 0.16 11.9 57.7 1.7 8.7 4.2 6.6 3 3 4 7 7 7 0 Transposase zinc-ribbon domain C1_4 PF07975.12 EMC81087.1 - 0.23 11.7 39.0 1 9.6 1.1 6.6 1 1 7 9 9 9 0 TFIIH C1-like domain DNA_RNApol_7kD PF03604.13 EMC81087.1 - 0.36 10.5 32.3 2 8.1 1.0 8.8 10 0 0 10 10 9 0 DNA directed RNA polymerase, 7 kDa subunit zf-C2H2_11 PF16622.5 EMC81087.1 - 0.37 10.6 42.0 1.7 8.4 0.1 8.4 8 0 0 8 8 8 0 zinc-finger C2H2-type IBR PF01485.21 EMC81087.1 - 1.1 9.6 47.0 3.8 7.8 5.9 5.9 1 1 4 5 5 5 0 IBR domain, a half RING-finger domain zf-RING_7 PF02591.15 EMC81087.1 - 1.5 9.0 36.0 11 6.4 0.1 9.4 10 0 0 10 10 10 0 C4-type zinc ribbon domain GAGA PF09237.11 EMC81087.1 - 1.6 8.6 28.3 1.2 8.9 0.1 6.8 1 1 6 8 8 8 0 GAGA factor PHD PF00628.29 EMC81087.1 - 1.6 8.6 37.3 1.5 8.8 1.2 6.3 4 2 3 7 7 7 0 PHD-finger zf-DNA_Pol PF08996.10 EMC81087.1 - 1.9 8.2 33.2 0.38 10.5 0.4 5.2 1 1 5 6 6 6 0 DNA Polymerase alpha zinc finger BDHCT_assoc PF16204.5 EMC81087.1 - 2.1 8.0 6.0 32 4.1 0.1 3.4 1 1 3 4 4 4 0 BDHCT-box associated domain on Bloom syndrome protein zf-ISL3 PF14690.6 EMC81087.1 - 2.4 8.9 48.6 2.8 8.7 0.9 9.8 9 1 1 10 10 10 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Scramblase PF03803.15 EMC81087.1 - 3.9 6.7 6.7 40 3.4 0.1 3.5 1 1 2 4 4 4 0 Scramblase zinc_ribbon_4 PF13717.6 EMC81087.1 - 6.3 6.8 47.3 12 6.0 0.3 9.4 8 2 0 8 8 8 0 zinc-ribbon domain VWD PF00094.25 EMC81088.1 - 4e-10 40.2 0.0 4.4e-10 40.0 0.0 1.0 1 0 0 1 1 1 1 von Willebrand factor type D domain VWD PF00094.25 EMC81089.1 - 6.5e-06 26.5 0.1 1.1e-05 25.8 0.1 1.4 1 0 0 1 1 1 1 von Willebrand factor type D domain VWD PF00094.25 EMC81090.1 - 2.9e-28 99.1 0.0 5.3e-28 98.3 0.0 1.4 2 0 0 2 2 2 1 von Willebrand factor type D domain C8 PF08742.11 EMC81090.1 - 1.3e-17 64.0 13.1 1.3e-17 64.0 13.1 2.4 2 0 0 2 2 2 1 C8 domain 7tm_4 PF13853.6 EMC81092.1 - 5.9e-40 137.7 18.5 7.7e-40 137.4 18.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC81092.1 - 5.8e-20 71.7 26.4 2.9e-19 69.4 26.4 2.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Rax2 PF12768.7 EMC81092.1 - 0.19 11.1 0.1 0.32 10.4 0.1 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity 7tm_4 PF13853.6 EMC81093.1 - 8.8e-11 42.0 3.6 1.2e-10 41.6 3.6 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC81093.1 - 1.7e-10 40.7 2.0 1.7e-10 40.7 2.0 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC81094.1 - 1.1e-07 31.9 2.5 1.3e-07 31.7 2.5 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC81094.1 - 0.00055 19.3 0.3 0.00076 18.9 0.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) AA_permease_2 PF13520.6 EMC81096.1 - 8.4e-26 90.8 0.5 9.7e-26 90.6 0.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMC81096.1 - 1.2e-15 57.1 0.1 1.4e-15 56.8 0.1 1.0 1 0 0 1 1 1 1 Amino acid permease RPAP1_N PF08621.10 EMC81096.1 - 0.19 11.5 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 RPAP1-like, N-terminal 7tm_4 PF13853.6 EMC81097.1 - 7.3e-11 42.3 1.4 8.7e-11 42.1 1.4 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC81097.1 - 1.4e-06 27.9 0.2 1.8e-06 27.5 0.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC81099.1 - 2.5e-11 43.8 4.4 6.8e-06 26.0 1.0 2.1 2 0 0 2 2 2 2 Olfactory receptor 7tm_1 PF00001.21 EMC81099.1 - 3.6e-05 23.2 1.2 0.0015 17.9 0.2 2.1 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC81100.1 - 1.4e-47 162.8 21.7 1.7e-47 162.5 21.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC81100.1 - 5.5e-22 78.3 23.7 7.5e-22 77.9 23.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC81101.1 - 6.3e-15 55.6 3.6 6.8e-15 55.5 3.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC81101.1 - 0.012 14.9 2.3 0.015 14.6 2.3 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Integrase_Zn PF02022.19 EMC81102.1 - 5.9e-14 51.8 1.4 5.9e-14 51.8 1.4 2.0 2 0 0 2 2 2 1 Integrase Zinc binding domain rve PF00665.26 EMC81102.1 - 0.1 12.8 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain DUF4620 PF15399.6 EMC81102.1 - 0.41 11.0 3.4 0.73 10.2 0.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4620) Sad1_UNC PF07738.13 EMC81103.1 - 2.6e-34 118.1 0.0 3e-34 117.9 0.0 1.0 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal DUF5000 PF16391.5 EMC81103.1 - 0.089 12.9 0.0 0.64 10.1 0.0 2.0 1 1 0 1 1 1 0 Domain of unknown function CHGN PF05679.16 EMC81104.1 - 1.4e-138 463.0 0.0 4e-136 454.9 0.0 2.1 1 1 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Fringe PF02434.16 EMC81104.1 - 2.4e-10 40.3 0.0 4.5e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Fringe-like Homeodomain PF00046.29 EMC81106.1 - 3.5e-25 87.6 6.2 3.8e-25 87.5 6.2 1.0 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC81106.1 - 0.0076 16.1 0.5 0.013 15.4 0.1 1.6 2 0 0 2 2 2 1 Homeobox KN domain Homez PF11569.8 EMC81106.1 - 0.11 12.0 0.3 0.13 11.7 0.2 1.3 1 1 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez ArfGap PF01412.18 EMC81107.1 - 1.1e-38 131.9 0.0 2e-38 131.0 0.0 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Ras PF00071.22 EMC81107.1 - 9.7e-18 64.3 0.0 3e-17 62.7 0.0 1.8 2 0 0 2 2 2 1 Ras family PH PF00169.29 EMC81107.1 - 3.1e-11 43.7 0.8 3.4e-05 24.3 0.0 3.3 3 0 0 3 3 3 2 PH domain Ank_4 PF13637.6 EMC81107.1 - 0.00042 20.8 0.0 0.0011 19.5 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) PH_6 PF15406.6 EMC81107.1 - 0.0014 18.9 0.0 0.0029 17.9 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain Roc PF08477.13 EMC81107.1 - 0.0027 17.9 0.0 0.011 16.0 0.0 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PH_11 PF15413.6 EMC81107.1 - 0.039 14.4 0.1 5.7 7.4 0.0 2.8 3 0 0 3 3 3 0 Pleckstrin homology domain TniB PF05621.11 EMC81107.1 - 0.078 12.4 0.0 4.3 6.7 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein Guanylate_kin PF00625.21 EMC81109.1 - 2.7e-68 229.2 0.0 3.1e-68 229.0 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_16 PF13191.6 EMC81109.1 - 1.8e-06 28.4 0.3 6e-06 26.7 0.3 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EMC81109.1 - 2.6e-05 24.8 0.1 5.3e-05 23.8 0.1 1.5 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EMC81109.1 - 2.8e-05 24.2 0.1 6.6e-05 23.0 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EMC81109.1 - 5e-05 23.8 0.0 8.2e-05 23.1 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AAA_33 PF13671.6 EMC81109.1 - 0.00034 20.8 0.2 0.0019 18.4 0.2 2.1 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EMC81109.1 - 0.00036 20.5 0.0 0.00079 19.4 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 EMC81109.1 - 0.00062 20.1 0.1 0.0021 18.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 EMC81109.1 - 0.0014 18.5 0.0 0.0027 17.6 0.0 1.4 1 0 0 1 1 1 1 NTPase AAA_14 PF13173.6 EMC81109.1 - 0.0027 17.7 0.0 0.0059 16.6 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.6 EMC81109.1 - 0.0056 17.1 0.8 0.041 14.3 0.8 2.3 1 1 0 1 1 1 1 AAA domain cobW PF02492.19 EMC81109.1 - 0.0057 16.3 0.1 0.015 14.8 0.0 1.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EMC81109.1 - 0.0062 16.5 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 NACHT domain RNA_helicase PF00910.22 EMC81109.1 - 0.0066 16.8 0.0 0.013 15.9 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_29 PF13555.6 EMC81109.1 - 0.0082 15.9 0.1 0.013 15.2 0.1 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 EMC81109.1 - 0.012 15.3 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EMC81109.1 - 0.015 15.7 0.0 0.04 14.3 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EMC81109.1 - 0.016 15.5 0.0 0.033 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EMC81109.1 - 0.018 14.6 0.0 0.029 13.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Rad17 PF03215.15 EMC81109.1 - 0.028 14.4 0.0 0.044 13.7 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain dNK PF01712.19 EMC81109.1 - 0.03 14.2 0.3 0.59 10.0 0.0 2.2 2 1 0 2 2 2 0 Deoxynucleoside kinase ATPase_2 PF01637.18 EMC81109.1 - 0.033 14.1 0.6 0.15 12.0 0.6 2.0 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 EMC81109.1 - 0.042 14.3 0.7 0.44 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EMC81109.1 - 0.043 13.1 0.0 0.09 12.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin NB-ARC PF00931.22 EMC81109.1 - 0.045 12.9 0.0 0.065 12.4 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain KAP_NTPase PF07693.14 EMC81109.1 - 0.045 13.0 0.0 0.077 12.2 0.0 1.5 1 1 0 1 1 1 0 KAP family P-loop domain AAA_5 PF07728.14 EMC81109.1 - 0.062 13.3 0.3 0.33 10.9 0.0 2.3 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EMC81109.1 - 0.071 12.8 0.0 0.22 11.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EMC81109.1 - 0.072 12.8 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF3734 PF12536.8 EMC81109.1 - 0.13 12.6 0.0 0.33 11.3 0.0 1.6 1 0 0 1 1 1 0 Patatin phospholipase TsaE PF02367.17 EMC81109.1 - 0.14 12.2 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mitoc_L55 PF09776.9 EMC81110.1 - 1.7e-32 111.6 0.0 1.9e-32 111.4 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L55 bMG1 PF17970.1 EMC81110.1 - 0.053 13.6 0.0 0.063 13.3 0.0 1.2 1 0 0 1 1 1 0 Bacterial Alpha-2-macroglobulin MG1 domain GAGA_bind PF06217.12 EMC81111.1 - 0.031 14.6 14.5 0.031 14.6 14.5 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family TFIIF_alpha PF05793.12 EMC81111.1 - 0.034 12.7 24.0 0.034 12.8 24.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF2052 PF09747.9 EMC81111.1 - 0.099 12.8 14.9 0.11 12.6 14.9 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) RR_TM4-6 PF06459.12 EMC81111.1 - 0.23 11.3 20.1 0.25 11.2 20.1 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FGF-BP1 PF06473.12 EMC81111.1 - 0.32 10.8 16.2 0.35 10.7 16.2 1.2 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) FCP1_C PF09309.10 EMC81111.1 - 0.33 10.8 22.4 0.48 10.3 22.4 1.2 1 0 0 1 1 1 0 FCP1, C-terminal CCDC106 PF15794.5 EMC81111.1 - 0.99 9.1 17.8 1.2 8.8 17.8 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DUF5399 PF17377.2 EMC81111.1 - 1.7 8.5 9.4 2.4 8.0 9.4 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5399) PPL5 PF18168.1 EMC81111.1 - 2.2 7.5 11.9 2.4 7.4 11.9 1.2 1 0 0 1 1 1 0 Prim-pol family 5 CENP-N PF05238.13 EMC81111.1 - 2.8 7.2 15.7 3.5 6.8 15.7 1.1 1 0 0 1 1 1 0 Kinetochore protein CHL4 like CPSF100_C PF13299.6 EMC81111.1 - 3.5 7.8 13.2 4.6 7.4 13.2 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Vfa1 PF08432.10 EMC81111.1 - 3.6 7.9 26.0 4.5 7.6 26.0 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Paramyxo_ncap PF00973.19 EMC81111.1 - 4.4 6.1 10.9 4.6 6.0 10.9 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Hydin_ADK PF17213.3 EMC81111.1 - 5.9 7.1 10.2 7.1 6.9 10.2 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Neur_chan_memb PF02932.16 EMC81111.1 - 7.1 6.6 9.0 7 6.6 9.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.14 EMC81111.1 - 7.5 4.7 16.2 7.2 4.8 16.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Tim54 PF11711.8 EMC81111.1 - 8 5.1 16.6 8.9 5.0 16.6 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 EOS1 PF12326.8 EMC81111.1 - 8.9 6.2 5.6 9.3 6.1 5.6 1.2 1 0 0 1 1 1 0 N-glycosylation protein Arf PF00025.21 EMC81113.1 - 5.2e-30 104.2 0.0 5.6e-30 104.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EMC81113.1 - 0.00092 18.7 0.0 0.001 18.5 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EMC81113.1 - 0.097 12.0 0.0 0.099 12.0 0.0 1.0 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region wnt PF00110.19 EMC81114.1 - 3.9e-101 338.7 21.7 4.3e-101 338.6 21.7 1.0 1 0 0 1 1 1 1 wnt family Yae1_N PF09811.9 EMC81115.1 - 1.6e-09 37.3 39.9 1.8e+04 -8.9 39.9 4.2 1 1 0 1 1 1 0 Essential protein Yae1, N terminal wnt PF00110.19 EMC81116.1 - 4.3e-99 332.0 25.0 5e-99 331.8 25.0 1.0 1 0 0 1 1 1 1 wnt family Clr5 PF14420.6 EMC81116.1 - 0.023 14.9 0.1 0.048 13.9 0.1 1.5 1 0 0 1 1 1 0 Clr5 domain GRAM PF02893.20 EMC81117.1 - 0.00042 20.2 0.2 0.0014 18.5 0.1 1.8 2 0 0 2 2 2 1 GRAM domain Metal_resist PF13801.6 EMC81117.1 - 0.049 13.8 0.1 0.091 13.0 0.1 1.4 1 0 0 1 1 1 0 Heavy-metal resistance DUF5089 PF17002.5 EMC81117.1 - 0.12 12.2 12.6 2.8 7.8 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5089) KxDL PF10241.9 EMC81117.1 - 0.56 10.5 7.5 1.6 9.1 3.3 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein DUF1664 PF07889.12 EMC81117.1 - 9.8 6.2 6.8 13 5.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Cupin_8 PF13621.6 EMC81118.1 - 3.2e-22 79.5 2.0 4.7e-22 78.9 2.0 1.2 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 EMC81118.1 - 3.7e-20 72.4 0.1 8.8e-20 71.2 0.1 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_4 PF08007.12 EMC81118.1 - 0.051 13.0 0.0 0.095 12.2 0.0 1.4 1 0 0 1 1 1 0 Cupin superfamily protein MORN PF02493.20 EMC81119.1 - 3.2e-21 73.9 37.3 1.9e-06 27.4 5.2 9.0 8 1 0 8 8 8 7 MORN repeat VPS9 PF02204.18 EMC81119.1 - 1.6e-16 60.4 0.1 3.7e-16 59.2 0.1 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Antimicrobial_6 PF08036.11 EMC81119.1 - 0.23 11.5 2.7 0.5 10.5 2.7 1.5 1 0 0 1 1 1 0 Diapausin family of antimicrobial peptide TMIE PF16038.5 EMC81120.1 - 4.5e-35 119.4 0.5 5.8e-35 119.0 0.5 1.1 1 0 0 1 1 1 1 TMIE protein Shisa PF13908.6 EMC81120.1 - 0.036 14.3 0.0 0.037 14.3 0.0 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator LST1 PF05083.13 EMC81120.1 - 0.058 13.7 0.1 0.1 12.9 0.1 1.5 1 1 0 1 1 1 0 LST-1 protein RCR PF12273.8 EMC81120.1 - 0.079 13.6 0.0 0.12 13.0 0.0 1.3 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red DUF3340 PF11818.8 EMC81120.1 - 0.17 12.1 5.8 0.35 11.0 5.3 1.6 2 0 0 2 2 2 0 C-terminal domain of tail specific protease (DUF3340) EF-hand_6 PF13405.6 EMC81121.1 - 1.2e-09 37.3 0.1 0.0086 15.9 0.0 4.3 5 1 0 5 5 5 2 EF-hand domain EF-hand_1 PF00036.32 EMC81121.1 - 1.4e-07 30.5 0.7 0.015 14.8 0.0 4.8 6 1 0 6 6 6 2 EF hand EF-hand_7 PF13499.6 EMC81121.1 - 0.0003 21.2 0.1 0.0035 17.8 0.0 2.5 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 EMC81121.1 - 0.0013 18.5 0.8 1.6 8.6 0.1 2.8 1 1 1 2 2 2 2 EF-hand domain pair DUF2267 PF10025.9 EMC81121.1 - 0.019 15.2 0.1 0.17 12.2 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2267) UPF0154 PF03672.13 EMC81121.1 - 0.14 12.2 0.0 1.7 8.7 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) 7tm_2 PF00002.24 EMC81122.1 - 1.1e-91 306.5 14.5 1.4e-91 306.2 14.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 EMC81122.1 - 1.3e-19 70.2 2.9 2.4e-19 69.4 2.9 1.5 1 0 0 1 1 1 1 Hormone receptor domain cwf18 PF08315.12 EMC81123.1 - 3.2e-33 115.3 15.9 3.8e-33 115.0 15.9 1.1 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor Arg_tRNA_synt_N PF03485.16 EMC81123.1 - 0.029 15.0 1.0 0.053 14.1 1.0 1.4 1 0 0 1 1 1 0 Arginyl tRNA synthetase N terminal domain Spore_III_AB PF09548.10 EMC81123.1 - 0.35 11.0 2.3 0.26 11.4 0.6 1.6 1 1 1 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) RHH_1 PF01402.21 EMC81123.1 - 0.38 10.8 4.7 0.65 10.0 1.6 2.6 2 0 0 2 2 2 0 Ribbon-helix-helix protein, copG family Cathelicidins PF00666.17 EMC81124.1 - 1.5e-23 83.0 0.0 2e-23 82.6 0.0 1.2 1 0 0 1 1 1 1 Cathelicidin Spp-24 PF07448.11 EMC81124.1 - 0.0044 17.2 0.1 0.0068 16.6 0.1 1.3 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Cathelicidins PF00666.17 EMC81125.1 - 7.5e-20 71.1 0.0 1e-19 70.7 0.0 1.2 1 0 0 1 1 1 1 Cathelicidin Spp-24 PF07448.11 EMC81125.1 - 0.014 15.6 0.1 0.026 14.7 0.1 1.4 1 0 0 1 1 1 0 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Cathelicidins PF00666.17 EMC81126.1 - 0.00051 20.3 3.3 0.0083 16.4 3.3 2.1 1 1 0 1 1 1 1 Cathelicidin FAST_1 PF06743.15 EMC81127.1 - 1.6e-27 95.2 3.9 5.3e-20 71.1 0.1 4.2 3 1 0 4 4 4 2 FAST kinase-like protein, subdomain 1 FAST_2 PF08368.12 EMC81127.1 - 2.4e-20 73.1 0.1 7.7e-20 71.5 0.0 1.9 2 0 0 2 2 2 1 FAST kinase-like protein, subdomain 2 NAC PF01849.18 EMC81128.1 - 3.4e-20 71.8 0.1 8.2e-20 70.5 0.1 1.7 2 0 0 2 2 2 1 NAC domain CCM2_C PF16545.5 EMC81129.1 - 2.2e-47 159.7 0.3 3.7e-47 158.9 0.3 1.4 1 0 0 1 1 1 1 Cerebral cavernous malformation protein, harmonin-homology DUF1722 PF08349.11 EMC81129.1 - 0.033 14.5 0.2 0.093 13.0 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1722) HTH_48 PF17906.1 EMC81129.1 - 0.19 11.9 0.0 0.48 10.6 0.0 1.7 1 0 0 1 1 1 0 HTH domain in Mos1 transposase ELP6 PF09807.9 EMC81130.1 - 4.7e-102 340.7 0.7 5.3e-102 340.5 0.7 1.0 1 0 0 1 1 1 1 Elongation complex protein 6 SWIRM-assoc_2 PF16496.5 EMC81131.1 - 2.2e-146 488.0 15.3 2.2e-146 488.0 15.3 2.3 2 0 0 2 2 2 1 SWIRM-associated domain at the N-terminal SWIRM PF04433.17 EMC81131.1 - 6.2e-31 106.6 2.3 6.3e-31 106.6 0.1 2.2 2 0 0 2 2 2 1 SWIRM domain SWIRM-assoc_3 PF16498.5 EMC81131.1 - 7.7e-31 106.2 1.3 7.7e-31 106.2 1.3 2.9 2 1 0 2 2 2 1 SWIRM-associated domain at the C-terminal SWIRM-assoc_1 PF16495.5 EMC81131.1 - 8e-30 102.6 17.0 8e-30 102.6 17.0 2.5 3 0 0 3 3 3 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 EMC81131.1 - 1e-12 48.0 0.2 2.7e-12 46.7 0.2 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EMC81131.1 - 1.4e-07 31.7 0.0 4.2e-07 30.1 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain BRCT_2 PF16589.5 EMC81131.1 - 0.0047 17.3 0.1 0.047 14.1 0.1 2.4 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain DUF919 PF06034.11 EMC81131.1 - 0.032 14.0 5.2 0.1 12.4 5.2 1.8 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DUF2618 PF10940.8 EMC81131.1 - 0.15 11.9 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2618) BRCT PF00533.26 EMC81131.1 - 0.16 12.4 0.0 3.7 8.0 0.0 2.6 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain Tubulin-binding PF00418.19 EMC81132.1 - 3e-49 164.7 23.5 2.1e-17 62.8 4.8 3.1 3 0 0 3 3 3 3 Tau and MAP protein, tubulin-binding repeat PRY PF13765.6 EMC81134.1 - 6.3e-21 73.8 0.1 1.2e-20 72.9 0.1 1.5 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.28 EMC81134.1 - 1.5e-13 50.9 0.0 1.8e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 SPRY domain Collagen PF01391.18 EMC81135.1 - 5.1e-19 67.8 34.9 2.6e-10 39.9 14.2 2.0 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) CRAM_rpt PF07016.11 EMC81135.1 - 1.1 9.2 7.4 41 4.1 0.8 3.8 1 1 3 4 4 4 0 Cysteine-rich acidic integral membrane protein precursor V-set PF07686.17 EMC81136.1 - 8.9e-06 25.8 0.0 1.1e-05 25.6 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC81136.1 - 0.11 13.2 0.1 0.15 12.7 0.1 1.2 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 EMC81137.1 - 3.6e-10 40.0 0.0 4.3e-10 39.7 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC81137.1 - 0.0012 19.4 0.0 0.0029 18.1 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC81137.1 - 0.0018 18.4 0.1 0.015 15.4 0.1 2.0 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC81138.1 - 1.4e-11 44.5 0.0 1.8e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC81138.1 - 1.3e-05 25.7 0.1 8.2e-05 23.1 0.1 1.9 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC81138.1 - 0.00023 21.3 0.1 0.0011 19.1 0.1 1.8 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC81138.1 - 0.091 13.1 0.2 1.7 9.0 0.2 2.0 1 1 0 1 1 1 0 Immunoglobulin domain Elong-fact-P_C PF09285.11 EMC81139.1 - 0.071 12.9 3.2 12 5.7 0.2 3.4 1 1 1 2 2 2 0 Elongation factor P, C-terminal OCRE PF17780.1 EMC81139.1 - 0.47 10.5 13.1 6.3 6.9 3.0 4.1 1 1 2 3 3 3 0 OCRE domain C1-set PF07654.15 EMC81140.1 - 1.1e-50 169.9 0.0 1.3e-20 73.6 0.0 4.2 4 0 0 4 4 4 4 Immunoglobulin C1-set domain Ig_3 PF13927.6 EMC81140.1 - 3.4e-17 62.8 2.7 0.00027 21.5 0.0 4.0 4 1 0 4 4 4 3 Immunoglobulin domain C2-set_2 PF08205.12 EMC81140.1 - 4.6e-14 52.2 0.7 0.0025 17.9 0.0 4.7 5 0 0 5 5 5 3 CD80-like C2-set immunoglobulin domain ig PF00047.25 EMC81140.1 - 6.1e-14 52.0 3.3 1.9e-05 24.7 0.1 4.4 4 1 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 EMC81140.1 - 1.1e-13 51.3 0.4 0.0019 18.5 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 EMC81140.1 - 1.3e-08 34.7 0.1 0.38 10.8 0.0 3.7 4 0 0 4 4 4 3 Immunoglobulin I-set domain V-set PF07686.17 EMC81140.1 - 5e-05 23.4 0.5 0.48 10.6 0.0 4.1 5 0 0 5 5 5 2 Immunoglobulin V-set domain C1-set PF07654.15 EMC81141.1 - 7.1e-60 199.4 0.0 6.3e-22 77.8 0.0 4.1 4 0 0 4 4 4 4 Immunoglobulin C1-set domain Ig_3 PF13927.6 EMC81141.1 - 2.8e-13 50.2 0.3 0.016 15.8 0.1 4.6 4 1 0 4 4 4 4 Immunoglobulin domain C2-set_2 PF08205.12 EMC81141.1 - 2.1e-12 47.0 0.2 0.018 15.1 0.1 4.1 4 0 0 4 4 4 3 CD80-like C2-set immunoglobulin domain ig PF00047.25 EMC81141.1 - 1.8e-11 44.0 0.0 0.11 12.7 0.0 4.9 4 1 0 4 4 4 4 Immunoglobulin domain I-set PF07679.16 EMC81141.1 - 0.0002 21.4 0.0 3.1 7.9 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin I-set domain C1-set PF07654.15 EMC81142.1 - 1.5e-22 79.8 0.0 1.7e-22 79.6 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin C1-set domain ig PF00047.25 EMC81142.1 - 8.7e-09 35.4 0.0 1e-08 35.2 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC81142.1 - 0.00021 21.8 0.0 0.00025 21.6 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 EMC81142.1 - 0.0051 16.8 0.0 0.0066 16.5 0.0 1.2 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 EMC81142.1 - 0.0056 17.0 0.0 0.0069 16.7 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain PT PF04886.12 EMC81143.1 - 7.9e-34 114.9 97.1 3.9e-08 32.7 12.4 8.2 2 2 1 3 3 3 2 PT repeat DUF1387 PF07139.11 EMC81144.1 - 1.8e-124 415.5 16.7 1.8e-124 415.5 16.7 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1387) CUE PF02845.16 EMC81144.1 - 0.081 12.6 0.1 0.18 11.5 0.1 1.7 1 0 0 1 1 1 0 CUE domain DUF1296 PF06972.11 EMC81144.1 - 2 8.6 8.3 0.42 10.8 3.4 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1296) Shugoshin_C PF07557.11 EMC81146.1 - 5.3e-11 42.1 0.6 1e-10 41.2 0.6 1.5 1 0 0 1 1 1 1 Shugoshin C terminus Ald_Xan_dh_C2 PF02738.18 EMC81147.1 - 1.9e-192 640.6 0.0 2.4e-192 640.3 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 EMC81147.1 - 5.8e-41 140.1 0.0 1.3e-40 138.9 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 EMC81147.1 - 9.1e-33 112.9 2.1 9.1e-33 112.9 2.1 1.8 2 0 0 2 2 2 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.20 EMC81147.1 - 5.9e-30 103.1 0.9 1.6e-29 101.7 0.9 1.8 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.17 EMC81147.1 - 2.1e-26 92.1 0.0 2.4e-25 88.7 0.0 2.5 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.27 EMC81147.1 - 1.1e-08 34.9 0.1 1.1e-08 34.9 0.1 3.3 3 0 0 3 3 3 1 2Fe-2S iron-sulfur cluster binding domain W2 PF02020.18 EMC81148.1 - 2.8e-22 78.7 8.0 1.6e-20 73.0 3.7 3.0 3 0 0 3 3 3 2 eIF4-gamma/eIF5/eIF2-epsilon Pkinase PF00069.25 EMC81149.1 - 3e-06 26.8 0.1 3.4e-06 26.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pro_isomerase PF00160.21 EMC81150.1 - 1.1e-52 178.4 0.0 1.3e-52 178.3 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD NIF3 PF01784.18 EMC81151.1 - 2e-35 122.6 0.0 2.3e-35 122.4 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) ORC2 PF04084.14 EMC81152.1 - 9.9e-107 356.7 1.6 1.4e-106 356.2 1.6 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 2 PARM PF17061.5 EMC81152.1 - 1 9.5 12.4 1.6 8.8 12.4 1.2 1 0 0 1 1 1 0 PARM Hyccin PF09790.9 EMC81153.1 - 7.6e-119 396.5 0.0 1e-118 396.1 0.0 1.2 1 0 0 1 1 1 1 Hyccin NDUF_B12 PF08122.12 EMC81154.1 - 4.3e-23 81.1 0.6 6.7e-23 80.5 0.6 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family DED PF01335.21 EMC81155.1 - 1.9e-31 108.2 16.6 2.8e-21 75.6 1.3 3.5 3 0 0 3 3 3 2 Death effector domain Peptidase_C14 PF00656.22 EMC81155.1 - 2.7e-21 76.7 0.0 4.1e-21 76.1 0.0 1.2 1 0 0 1 1 1 1 Caspase domain DED PF01335.21 EMC81156.1 - 1.9e-40 137.0 20.9 1.9e-20 72.9 4.6 2.8 3 0 0 3 3 3 2 Death effector domain Peptidase_C14 PF00656.22 EMC81156.1 - 4.7e-34 118.4 0.0 9.8e-34 117.4 0.0 1.5 1 1 0 1 1 1 1 Caspase domain NOB1_Zn_bind PF08772.11 EMC81156.1 - 0.078 13.2 0.1 0.28 11.4 0.0 2.0 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like DED PF01335.21 EMC81157.1 - 5.1e-44 148.5 16.7 1.3e-22 79.9 1.7 2.8 3 0 0 3 3 3 2 Death effector domain Peptidase_C14 PF00656.22 EMC81157.1 - 1.4e-43 149.7 0.1 2.3e-40 139.1 0.0 2.2 2 0 0 2 2 2 2 Caspase domain RasGAP_C PF03836.15 EMC81157.1 - 0.11 12.7 1.9 0.24 11.5 1.9 1.5 1 0 0 1 1 1 0 RasGAP C-terminus Peptidase_C14 PF00656.22 EMC81158.1 - 2.7e-46 158.6 0.1 3.9e-46 158.0 0.1 1.2 1 0 0 1 1 1 1 Caspase domain DED PF01335.21 EMC81158.1 - 4e-43 145.6 18.5 5.1e-23 81.2 6.2 2.7 3 0 0 3 3 3 2 Death effector domain PYRIN PF02758.16 EMC81158.1 - 0.015 15.4 8.8 0.049 13.8 1.1 2.7 2 1 0 2 2 2 0 PAAD/DAPIN/Pyrin domain YihI PF04220.12 EMC81158.1 - 0.04 13.6 0.5 0.071 12.8 0.5 1.3 1 0 0 1 1 1 0 Der GTPase activator (YihI) L27 PF02828.16 EMC81158.1 - 0.057 13.2 0.3 0.79 9.5 0.4 2.4 2 0 0 2 2 2 0 L27 domain Pkinase PF00069.25 EMC81159.1 - 4.8e-38 131.0 0.0 4.5e-37 127.9 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81159.1 - 1.3e-28 100.0 0.0 9.6e-25 87.3 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EMC81159.1 - 0.073 12.4 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Kinase-like ASXH PF13919.6 EMC81159.1 - 0.15 12.1 0.1 0.27 11.2 0.1 1.3 1 0 0 1 1 1 0 Asx homology domain TMEM237 PF15383.6 EMC81160.1 - 1.3e-101 338.9 0.1 1.6e-101 338.6 0.1 1.1 1 0 0 1 1 1 1 Transmembrane protein 237 RCC1 PF00415.18 EMC81161.1 - 3e-40 136.6 16.1 2.3e-11 44.1 0.1 7.2 7 1 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EMC81161.1 - 4.3e-28 96.5 25.5 2.4e-09 36.7 1.8 7.4 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat MORN PF02493.20 EMC81161.1 - 7.6e-25 85.3 30.4 2.6e-05 23.8 2.7 9.3 8 1 0 8 8 8 7 MORN repeat VPS9 PF02204.18 EMC81161.1 - 5.7e-24 84.3 0.1 6.7e-23 80.9 0.2 2.5 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain RhoGEF PF00621.20 EMC81161.1 - 7e-05 23.1 1.3 0.00016 21.9 1.3 1.7 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 EMC81161.1 - 0.0018 18.7 0.0 0.0053 17.2 0.0 1.8 1 0 0 1 1 1 1 PH domain Rad60-SLD PF11976.8 EMC81162.1 - 7.1e-22 77.0 0.2 8.5e-22 76.8 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EMC81162.1 - 2e-18 65.9 0.7 2.4e-18 65.7 0.7 1.1 1 0 0 1 1 1 1 Ubiquitin family Nop PF01798.18 EMC81163.1 - 5.8e-85 284.4 0.1 9.9e-85 283.7 0.1 1.4 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EMC81163.1 - 9.8e-24 83.5 2.3 9.8e-24 83.5 2.3 2.3 2 0 0 2 2 2 1 NOP5NT (NUC127) domain DUF2247 PF10004.9 EMC81163.1 - 0.013 15.3 1.0 0.13 12.0 0.1 2.5 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2247) tRNA-synt_His PF13393.6 EMC81163.1 - 0.018 14.3 1.1 0.27 10.4 1.0 2.3 2 0 0 2 2 2 0 Histidyl-tRNA synthetase HD_3 PF13023.6 EMC81163.1 - 0.53 10.2 3.1 0.55 10.1 0.8 2.2 2 1 0 2 2 2 0 HD domain Pkinase PF00069.25 EMC81164.1 - 8.1e-33 113.9 0.0 1.4e-32 113.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81164.1 - 2.5e-29 102.3 0.0 5.4e-29 101.3 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Activin_recp PF01064.23 EMC81164.1 - 1.2e-11 45.5 7.3 1.2e-11 45.5 7.3 2.0 2 0 0 2 2 2 1 Activin types I and II receptor domain APH PF01636.23 EMC81164.1 - 0.0015 18.5 0.0 0.0036 17.2 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 EMC81164.1 - 0.043 13.4 0.0 0.081 12.5 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Cadherin_C_2 PF16492.5 EMC81164.1 - 0.067 13.9 0.1 1.1 10.0 0.0 2.9 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal FAM117 PF15388.6 EMC81165.1 - 3.8e-123 410.9 14.4 5.3e-123 410.4 14.4 1.2 1 0 0 1 1 1 1 Protein Family FAM117 CagY_I PF14585.6 EMC81165.1 - 3.6 7.7 8.1 0.34 11.0 1.8 2.5 3 0 0 3 3 3 0 CagY type 1 repeat Homeodomain PF00046.29 EMC81167.1 - 7.5e-14 51.3 0.5 1.1e-13 50.7 0.5 1.2 1 0 0 1 1 1 1 Homeodomain Ank_5 PF13857.6 EMC81169.1 - 1.8e-09 37.6 0.0 2.2e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EMC81169.1 - 7.5e-08 32.5 0.0 1.5e-05 25.2 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 EMC81169.1 - 3.6e-07 30.7 0.0 5.6e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC81169.1 - 4.8e-07 29.6 0.0 2.3e-05 24.4 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 EMC81169.1 - 0.0001 22.8 0.0 0.00021 21.8 0.0 1.5 1 1 0 1 1 1 1 Ankyrin repeats (many copies) START PF01852.19 EMC81170.1 - 1e-14 54.5 0.0 4.5e-11 42.6 0.0 2.3 2 0 0 2 2 2 2 START domain DUF4097 PF13349.6 EMC81170.1 - 4.8e-06 26.1 13.0 0.00033 20.1 5.0 2.1 1 1 1 2 2 2 2 Putative adhesin Spc7 PF08317.11 EMC81170.1 - 0.18 10.6 0.8 0.87 8.4 0.2 1.6 1 1 1 2 2 2 0 Spc7 kinetochore protein SapB_2 PF03489.17 EMC81174.1 - 0.58 10.3 21.8 1.8 8.7 0.8 5.1 5 0 0 5 5 5 0 Saposin-like type B, region 2 RhoGAP PF00620.27 EMC81175.1 - 1.8e-37 128.5 0.0 3.5e-37 127.6 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain ArfGap PF01412.18 EMC81175.1 - 9.7e-29 99.8 0.0 2.9e-28 98.3 0.0 1.9 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 EMC81175.1 - 1.7e-26 92.8 0.0 5e-09 36.6 0.2 4.8 4 1 0 4 4 4 3 PH domain PH_11 PF15413.6 EMC81175.1 - 1.1e-10 41.8 4.5 0.073 13.5 0.0 5.3 4 1 0 4 4 4 3 Pleckstrin homology domain RA PF00788.23 EMC81175.1 - 1.4e-09 38.5 0.2 2.9e-09 37.4 0.2 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PH_6 PF15406.6 EMC81175.1 - 8.8e-08 32.4 0.1 0.00018 21.8 0.0 3.0 3 0 0 3 3 3 2 Pleckstrin homology domain PH_3 PF14593.6 EMC81175.1 - 9.1e-08 32.2 0.2 0.0011 19.1 0.2 3.5 3 0 0 3 3 3 2 PH domain PH_8 PF15409.6 EMC81175.1 - 2.7e-07 30.7 1.2 0.024 14.9 0.5 3.8 4 0 0 4 4 4 2 Pleckstrin homology domain PH_2 PF08458.10 EMC81175.1 - 6.1e-05 23.3 0.5 0.79 10.1 0.0 3.5 4 0 0 4 4 4 2 Plant pleckstrin homology-like region PH_13 PF16652.5 EMC81175.1 - 0.00033 20.5 0.1 0.7 9.7 0.1 3.0 3 0 0 3 3 3 2 Pleckstrin homology domain PH_9 PF15410.6 EMC81175.1 - 0.0093 16.3 0.6 6.2 7.2 0.0 3.6 3 1 0 3 3 3 1 Pleckstrin homology domain PH_4 PF15404.6 EMC81175.1 - 0.18 11.6 0.3 7.2 6.4 0.1 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain DUF4266 PF14086.6 EMC81175.1 - 6.7 7.8 9.2 19 6.3 4.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4266) FEZ PF07763.13 EMC81176.1 - 3.2e-14 53.3 8.9 7.6e-14 52.0 8.9 1.6 1 1 0 1 1 1 1 FEZ-like protein PTPRCAP PF15713.5 EMC81176.1 - 0.0099 16.2 9.3 0.012 15.9 9.3 1.1 1 0 0 1 1 1 1 Protein tyrosine phosphatase receptor type C-associated RNA_pol_3_Rpc31 PF11705.8 EMC81176.1 - 2.4 8.4 13.4 3.4 7.9 13.4 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Pkinase PF00069.25 EMC81178.1 - 9.3e-68 228.4 0.0 1.5e-67 227.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81178.1 - 1.1e-29 103.5 0.0 1.7e-29 102.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMC81178.1 - 1.4e-06 27.8 0.0 2.6e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RRN7 PF11781.8 EMC81178.1 - 0.00056 19.5 0.2 0.0016 18.1 0.2 1.9 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Pkinase_fungal PF17667.1 EMC81178.1 - 0.0007 18.5 0.0 0.0012 17.7 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMC81178.1 - 0.0022 17.9 0.1 1.7 8.5 0.0 2.9 2 1 1 3 3 3 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EMC81178.1 - 0.012 14.6 0.0 0.021 13.8 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Mob1_phocein PF03637.17 EMC81179.1 - 8.8e-78 260.1 0.6 1e-77 259.9 0.6 1.0 1 0 0 1 1 1 1 Mob1/phocein family BLOC1_2 PF10046.9 EMC81180.1 - 0.00019 21.7 4.4 0.00019 21.7 4.4 2.5 2 0 0 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fib_alpha PF08702.10 EMC81180.1 - 0.02 15.1 2.2 0.02 15.1 2.2 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family EF-hand_6 PF13405.6 EMC81180.1 - 0.021 14.7 0.9 1.2 9.2 0.1 2.9 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.32 EMC81180.1 - 0.065 12.8 0.1 0.93 9.2 0.0 2.4 2 0 0 2 2 2 0 EF hand DUF730 PF05325.11 EMC81180.1 - 0.077 13.0 0.3 0.14 12.2 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF730) LPP PF04728.13 EMC81180.1 - 0.087 13.2 0.3 0.087 13.2 0.3 3.4 4 1 0 4 4 3 0 Lipoprotein leucine-zipper Atg14 PF10186.9 EMC81180.1 - 0.092 11.8 4.0 0.19 10.8 4.0 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FapA PF03961.13 EMC81180.1 - 0.094 11.3 2.1 0.15 10.6 2.1 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4047 PF13256.6 EMC81180.1 - 0.18 12.0 2.7 0.58 10.4 2.7 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) EF-hand_7 PF13499.6 EMC81180.1 - 0.19 12.2 3.2 0.5 10.9 1.5 2.6 2 1 0 2 2 2 0 EF-hand domain pair CC2-LZ PF16516.5 EMC81180.1 - 0.32 11.4 4.5 0.85 10.0 2.5 2.5 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Tetraspanin PF00335.20 EMC81180.1 - 0.36 10.5 7.1 0.56 9.9 0.2 2.2 2 0 0 2 2 2 0 Tetraspanin family SlyX PF04102.12 EMC81180.1 - 0.38 11.4 7.3 24 5.6 0.0 4.5 3 1 1 4 4 4 0 SlyX HsbA PF12296.8 EMC81180.1 - 0.39 11.1 7.0 6.3 7.2 0.3 3.0 3 0 0 3 3 2 0 Hydrophobic surface binding protein A FlaC_arch PF05377.11 EMC81180.1 - 0.46 10.9 8.2 0.3 11.5 0.6 3.5 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF489 PF04356.12 EMC81180.1 - 0.54 10.3 5.3 0.58 10.1 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF489) DUF948 PF06103.11 EMC81180.1 - 2.1 8.7 5.2 4.9 7.5 2.3 3.0 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 EMC81180.1 - 3.1 7.8 6.5 17 5.5 4.3 2.9 2 2 0 2 2 2 0 Protein of unknown function (DUF1664) Lectin_N PF03954.14 EMC81180.1 - 5.8 6.7 17.7 0.054 13.2 1.6 3.1 1 1 1 3 3 3 0 Hepatic lectin, N-terminal domain SKA2 PF16740.5 EMC81180.1 - 6.9 6.5 10.3 44 3.9 5.4 3.5 2 1 0 2 2 2 0 Spindle and kinetochore-associated protein 2 MAP17 PF15807.5 EMC81181.1 - 6.3e-28 97.5 0.4 7.4e-28 97.3 0.4 1.0 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Epiglycanin_C PF14654.6 EMC81181.1 - 0.008 16.2 0.0 0.0093 16.0 0.0 1.2 1 0 0 1 1 1 1 Mucin, catalytic, TM and cytoplasmic tail region SurA_N_2 PF13623.6 EMC81181.1 - 0.037 13.9 0.0 0.04 13.8 0.0 1.2 1 0 0 1 1 1 0 SurA N-terminal domain Fer4_5 PF12801.7 EMC81181.1 - 0.049 13.6 1.6 0.071 13.1 1.6 1.3 1 0 0 1 1 1 0 4Fe-4S binding domain EI24 PF07264.11 EMC81181.1 - 0.076 13.2 0.0 0.076 13.2 0.0 1.1 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) HLH PF00010.26 EMC81182.1 - 4.8e-12 45.6 0.6 8.9e-12 44.8 0.6 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain STIL_N PF15253.6 EMC81183.1 - 7.2e-205 680.5 0.0 1.1e-204 679.9 0.0 1.3 1 0 0 1 1 1 1 SCL-interrupting locus protein N-terminus ADK PF00406.22 EMC81184.1 - 2.5e-44 151.0 0.0 3.2e-44 150.7 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EMC81184.1 - 1.3e-39 135.7 0.0 1.8e-39 135.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMC81184.1 - 2e-07 31.6 0.0 3.1e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EMC81184.1 - 1.3e-06 28.3 0.0 0.0002 21.1 0.0 2.1 1 1 0 1 1 1 1 Thymidylate kinase AAA_33 PF13671.6 EMC81184.1 - 4.8e-05 23.5 0.0 8.8e-05 22.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EMC81184.1 - 0.00024 20.4 0.0 0.00031 20.1 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin Cytidylate_kin PF02224.18 EMC81184.1 - 0.015 15.0 0.1 2.1 8.1 0.0 2.2 2 0 0 2 2 2 0 Cytidylate kinase PAS_9 PF13426.7 EMC81184.1 - 0.048 13.9 0.0 1.1 9.5 0.0 2.2 2 0 0 2 2 2 0 PAS domain Ploopntkinase3 PF18751.1 EMC81184.1 - 0.12 12.2 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 Forkhead PF00250.18 EMC81185.1 - 3.2e-15 56.1 0.0 5e-15 55.5 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain TraB PF01963.17 EMC81186.1 - 7.5e-24 85.0 0.0 8.1e-24 84.9 0.0 1.0 1 0 0 1 1 1 1 TraB family TraB PF01963.17 EMC81187.1 - 7.2e-38 131.0 0.0 8.2e-38 130.8 0.0 1.0 1 0 0 1 1 1 1 TraB family SSF PF00474.17 EMC81188.1 - 3.5e-148 493.8 20.9 5e-148 493.3 20.9 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family PIRT PF15099.6 EMC81188.1 - 5.1 6.7 6.7 0.96 9.0 0.8 2.5 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family Peptidase_M14 PF00246.24 EMC81190.1 - 9.5e-19 68.3 0.0 4.7e-18 66.0 0.0 2.0 1 1 0 1 1 1 1 Zinc carboxypeptidase BEN PF10523.9 EMC81191.1 - 1.1e-15 57.7 0.1 2.3e-15 56.6 0.1 1.6 1 0 0 1 1 1 1 BEN domain Pepdidase_M14_N PF18027.1 EMC81192.1 - 5.4e-07 30.0 0.0 7e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain C5HCH PF17982.1 EMC81192.1 - 0.077 13.2 0.1 0.11 12.7 0.1 1.3 1 0 0 1 1 1 0 NSD Cys-His rich domain Drf_FH1 PF06346.12 EMC81193.1 - 9e-09 35.2 104.9 0.00072 19.3 41.5 3.0 1 1 2 3 3 3 3 Formin Homology Region 1 NpwBP PF12622.7 EMC81194.1 - 0.0029 18.3 14.7 94 3.9 0.2 6.6 1 1 6 7 7 7 0 mRNA biogenesis factor gerPA PF10676.9 EMC81194.1 - 0.0075 16.5 0.0 45 4.4 0.0 3.0 1 1 1 3 3 3 3 Spore germination protein gerPA/gerPF MRP-L20 PF12824.7 EMC81194.1 - 0.72 10.0 14.4 1.2e+02 2.8 0.1 5.5 1 1 5 6 6 6 0 Mitochondrial ribosomal protein subunit L20 UBX PF00789.20 EMC81195.1 - 3e-21 75.4 0.1 7.6e-21 74.1 0.1 1.7 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 EMC81195.1 - 6.3e-07 29.1 0.7 1.5e-06 27.9 0.7 1.6 1 0 0 1 1 1 1 UBA-like domain ubiquitin PF00240.23 EMC81195.1 - 0.0099 15.6 0.0 10 6.0 0.0 3.1 3 0 0 3 3 3 2 Ubiquitin family Borrelia_P83 PF05262.11 EMC81195.1 - 0.37 9.2 6.4 0.53 8.7 6.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein AAA_23 PF13476.6 EMC81195.1 - 2.3 8.7 8.1 4.6 7.7 8.1 1.4 1 0 0 1 1 1 0 AAA domain Ank_5 PF13857.6 EMC81196.1 - 1.4e-20 73.1 2.8 2e-11 43.9 0.3 3.2 2 1 0 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC81196.1 - 6.6e-17 61.7 0.2 2.2e-08 34.5 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC81196.1 - 1.3e-15 57.7 0.4 4.6e-09 36.8 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EMC81196.1 - 6.2e-15 54.9 1.9 2.1e-05 24.7 0.1 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 EMC81196.1 - 3.6e-11 42.2 0.8 0.0048 17.3 0.1 4.0 4 0 0 4 4 4 3 Ankyrin repeat zf-RING_2 PF13639.6 EMC81197.1 - 3.5e-12 46.4 5.6 4.8e-12 46.0 5.6 1.2 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EMC81197.1 - 2.2e-11 43.3 4.6 2.2e-11 43.3 4.6 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EMC81197.1 - 9.1e-08 32.0 2.8 1.7e-07 31.2 2.8 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EMC81197.1 - 4.5e-07 29.6 6.0 6.5e-07 29.1 6.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMC81197.1 - 2.3e-06 27.8 7.9 1.2e-05 25.4 7.9 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EMC81197.1 - 3e-06 27.0 2.2 4.3e-06 26.5 2.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC81197.1 - 3.6e-06 26.7 3.5 5.7e-06 26.1 3.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC81197.1 - 3e-05 23.9 1.7 4.8e-05 23.2 1.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EMC81197.1 - 5.1e-05 22.8 2.7 8.4e-05 22.1 2.7 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 EMC81197.1 - 0.00012 21.9 2.2 0.00018 21.3 2.2 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EMC81197.1 - 0.062 13.5 3.7 0.11 12.6 3.7 1.5 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 EMC81197.1 - 0.084 12.8 1.6 0.13 12.1 1.6 1.2 1 0 0 1 1 1 0 zf-RING of BARD1-type protein BCDHK_Adom3 PF10436.9 EMC81197.1 - 0.14 12.0 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase zf-C3H2C3 PF17122.5 EMC81197.1 - 0.15 12.1 3.9 0.37 10.9 3.9 1.8 1 1 0 1 1 1 0 Zinc-finger FANCL_C PF11793.8 EMC81197.1 - 0.19 11.9 8.2 4.4 7.5 8.2 2.6 1 1 0 1 1 1 0 FANCL C-terminal domain zf-ANAPC11 PF12861.7 EMC81197.1 - 0.36 10.9 6.9 4.1 7.5 7.2 2.3 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF3808 PF10300.9 EMC81198.1 - 1.8e-163 544.7 2.0 2.6e-163 544.2 2.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_16 PF13432.6 EMC81198.1 - 6e-09 36.4 2.0 0.0082 16.8 0.0 5.1 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EMC81198.1 - 4e-08 33.4 4.0 8.6e-06 26.0 0.6 3.4 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMC81198.1 - 2e-05 25.0 0.3 0.037 14.9 0.1 4.2 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EMC81198.1 - 0.0012 19.3 7.3 0.28 11.7 0.4 5.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_10 PF13374.6 EMC81198.1 - 0.0019 18.0 3.7 0.048 13.6 0.6 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EMC81198.1 - 0.003 17.5 11.8 0.075 13.2 1.3 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMC81198.1 - 0.0031 18.0 2.7 0.2 12.4 1.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EMC81198.1 - 0.0066 16.6 4.0 6.2 7.3 0.4 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EMC81198.1 - 0.038 13.8 6.7 1.7 8.6 1.4 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EMC81198.1 - 0.07 13.2 2.2 0.37 10.9 0.4 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 EMC81198.1 - 0.09 13.5 0.2 7.4 7.5 0.1 3.8 3 0 0 3 3 2 0 Tetratricopeptide repeat EF-hand_4 PF12763.7 EMC81199.1 - 4.2e-41 139.1 0.2 2.3e-23 82.1 0.0 3.8 4 0 0 4 4 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EMC81199.1 - 2e-11 42.6 6.2 0.0026 17.2 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EMC81199.1 - 2.4e-07 30.1 1.8 1.1 9.4 0.0 4.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 EMC81199.1 - 6.7e-06 25.8 3.3 0.068 13.0 0.4 3.3 4 0 0 4 4 3 2 EF-hand domain pair EF-hand_7 PF13499.6 EMC81199.1 - 7.5e-06 26.3 4.2 0.46 11.0 0.0 4.8 3 2 2 5 5 5 2 EF-hand domain pair EF-hand_5 PF13202.6 EMC81199.1 - 6.3e-05 22.3 3.8 0.78 9.3 0.1 3.7 3 0 0 3 3 3 2 EF hand ATG16 PF08614.11 EMC81199.1 - 0.0069 16.6 16.6 0.0069 16.6 16.6 4.4 2 1 3 5 5 5 3 Autophagy protein 16 (ATG16) TMF_DNA_bd PF12329.8 EMC81199.1 - 0.01 15.8 20.3 0.01 15.8 20.3 4.7 3 1 3 6 6 4 0 TATA element modulatory factor 1 DNA binding AAA_13 PF13166.6 EMC81199.1 - 0.017 13.8 26.7 0.45 9.1 26.7 2.2 1 1 0 1 1 1 0 AAA domain APG6_N PF17675.1 EMC81199.1 - 0.056 14.0 52.9 0.49 10.9 13.2 3.6 2 1 1 3 3 3 0 Apg6 coiled-coil region ESSS PF10183.9 EMC81199.1 - 0.093 13.0 0.5 0.25 11.6 0.5 1.7 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) HOOK PF05622.12 EMC81199.1 - 0.13 10.4 36.3 0.005 15.1 21.4 2.2 1 1 1 2 2 2 0 HOOK protein Fib_alpha PF08702.10 EMC81199.1 - 0.2 11.8 23.9 0.26 11.5 8.7 2.6 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family UIM PF02809.20 EMC81199.1 - 0.25 11.3 6.1 0.49 10.4 3.5 2.8 2 0 0 2 2 2 0 Ubiquitin interaction motif TMPIT PF07851.13 EMC81199.1 - 2.1 7.5 26.8 0.18 11.0 14.2 2.3 1 1 1 2 2 2 0 TMPIT-like protein Spc7 PF08317.11 EMC81199.1 - 2.3 7.0 48.9 0.0056 15.6 22.4 2.7 2 1 1 3 3 2 0 Spc7 kinetochore protein Laminin_II PF06009.12 EMC81199.1 - 3.1 7.8 20.8 11 6.1 2.7 2.8 1 1 1 2 2 2 0 Laminin Domain II DUF3584 PF12128.8 EMC81199.1 - 4.1 4.8 38.6 0.028 12.0 29.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) COG2 PF06148.11 EMC81199.1 - 9.9 6.3 22.6 4 7.5 10.5 3.0 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Yae1_N PF09811.9 EMC81201.1 - 7.1e-15 54.4 53.2 1.8e+04 -18.3 53.2 5.1 1 1 0 1 1 1 0 Essential protein Yae1, N terminal Ras PF00071.22 EMC81204.1 - 1e-50 171.5 0.0 1.3e-50 171.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC81204.1 - 3e-18 66.2 0.0 4.8e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC81204.1 - 4.6e-10 39.2 0.0 6.1e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family ATP_bind_1 PF03029.17 EMC81204.1 - 0.00098 19.0 0.3 0.012 15.4 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 EMC81204.1 - 0.0026 17.3 0.0 0.003 17.1 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EMC81204.1 - 0.017 15.0 0.0 2.8 7.8 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase NADH_Oxid_Nqo15 PF11497.8 EMC81204.1 - 0.083 12.9 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 NADH-quinone oxidoreductase chain 15 C2 PF00168.30 EMC81205.1 - 6.5e-44 148.4 0.0 4.3e-21 75.1 0.0 2.4 2 0 0 2 2 2 2 C2 domain PTEN_C2 PF10409.9 EMC81205.1 - 0.0082 15.9 0.1 0.027 14.2 0.0 1.9 2 0 0 2 2 2 1 C2 domain of PTEN tumour-suppressor protein CEP76-C2 PF15627.6 EMC81205.1 - 0.022 14.4 0.0 3.1 7.4 0.0 2.4 2 0 0 2 2 2 0 CEP76 C2 domain AT_hook PF02178.19 EMC81206.1 - 4.8 7.4 39.9 0.11 12.5 1.5 5.2 4 0 0 4 4 4 0 AT hook motif UT PF03253.14 EMC81207.1 - 1e-210 697.7 77.0 5.1e-106 354.1 36.1 2.0 2 0 0 2 2 2 2 Urea transporter Gly-zipper_YMGG PF13441.6 EMC81207.1 - 0.91 9.3 4.4 17 5.2 0.3 2.8 2 0 0 2 2 2 0 YMGG-like Gly-zipper UCH PF00443.29 EMC81208.1 - 0.013 15.0 0.1 0.032 13.7 0.1 1.7 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase RVT_1 PF00078.27 EMC81209.1 - 0.012 15.2 0.0 0.1 12.1 0.0 2.4 3 0 0 3 3 3 0 Reverse transcriptase (RNA-dependent DNA polymerase) LMBR1 PF04791.16 EMC81210.1 - 0.011 14.7 4.7 0.015 14.3 4.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein AAA_11 PF13086.6 EMC81210.1 - 0.012 15.4 2.7 0.31 10.8 4.4 1.9 2 0 0 2 2 2 0 AAA domain zf-C4H2 PF10146.9 EMC81210.1 - 0.98 9.7 9.5 1.8 8.8 9.5 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein RNF111_N PF15303.6 EMC81212.1 - 1.1e-43 150.1 25.0 1.1e-43 150.1 25.0 1.6 2 0 0 2 2 2 1 E3 ubiquitin-protein ligase Arkadia N-terminus PLAT PF01477.23 EMC81215.1 - 1.1e-275 896.7 46.8 2e-26 92.9 0.4 15.0 15 0 0 15 15 15 14 PLAT/LH2 domain ATS3 PF06232.11 EMC81215.1 - 1.5e-19 70.1 0.4 0.029 14.3 0.0 10.7 12 1 0 12 12 12 4 Embryo-specific protein 3, (ATS3) NINJA_B PF16136.5 EMC81215.1 - 0.006 16.9 0.7 0.017 15.5 0.7 1.7 1 0 0 1 1 1 1 Putative nuclear localisation signal Glyco_transf_29 PF00777.18 EMC81216.1 - 5.8e-78 262.0 0.1 7.9e-78 261.6 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) RVT_1 PF00078.27 EMC81217.1 - 0.0016 18.0 0.0 0.0025 17.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PINIT PF14324.6 EMC81218.1 - 7.8e-35 120.4 0.0 1.5e-34 119.4 0.0 1.5 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 EMC81218.1 - 2.9e-22 78.1 5.0 5.6e-22 77.2 5.0 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EMC81218.1 - 5.7e-05 22.9 1.6 0.00018 21.3 1.6 1.9 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SAP PF02037.27 EMC81218.1 - 0.013 15.3 0.0 0.033 14.0 0.0 1.7 1 0 0 1 1 1 0 SAP domain PHD PF00628.29 EMC81218.1 - 0.23 11.4 2.2 0.47 10.4 2.2 1.5 1 0 0 1 1 1 0 PHD-finger AAA PF00004.29 EMC81219.1 - 1.2e-37 129.3 0.0 2.5e-37 128.3 0.0 1.5 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMC81219.1 - 5e-11 42.2 0.0 2e-10 40.3 0.0 2.1 2 0 0 2 2 2 1 AAA+ lid domain RuvB_N PF05496.12 EMC81219.1 - 5.4e-05 23.0 0.0 0.00011 22.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EMC81219.1 - 0.00026 21.4 0.0 0.00071 20.0 0.0 1.8 2 1 0 2 2 1 1 AAA ATPase domain TIP49 PF06068.13 EMC81219.1 - 0.00057 19.2 0.0 0.00092 18.5 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_5 PF07728.14 EMC81219.1 - 0.00066 19.7 0.0 0.0017 18.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EMC81219.1 - 0.0013 18.5 0.0 0.0085 15.8 0.0 2.2 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 EMC81219.1 - 0.0022 18.3 0.1 0.0075 16.5 0.1 1.8 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EMC81219.1 - 0.006 16.0 0.0 0.013 14.9 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EMC81219.1 - 0.0062 16.9 0.0 0.02 15.3 0.0 1.9 2 0 0 2 2 1 1 RNA helicase AAA_14 PF13173.6 EMC81219.1 - 0.0064 16.5 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EMC81219.1 - 0.0069 15.9 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 EMC81219.1 - 0.0094 15.7 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 EMC81219.1 - 0.029 14.5 0.0 0.055 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EMC81219.1 - 0.033 14.7 0.0 0.08 13.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EMC81219.1 - 0.051 13.2 0.5 0.24 11.0 0.2 2.1 2 1 1 3 3 3 0 AAA domain TsaE PF02367.17 EMC81219.1 - 0.07 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 EMC81219.1 - 0.09 12.5 0.0 1.7 8.4 0.0 2.5 3 0 0 3 3 3 0 Sigma-54 interaction domain DUF815 PF05673.13 EMC81219.1 - 0.1 11.8 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PhoH PF02562.16 EMC81219.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein Parvo_NS1 PF01057.17 EMC81219.1 - 0.14 11.3 0.0 0.25 10.4 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_28 PF13521.6 EMC81219.1 - 0.17 12.1 0.0 0.32 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Hydrolase_like PF13242.6 EMC81220.1 - 2.7e-20 72.2 0.0 5.1e-20 71.3 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 EMC81220.1 - 3.5e-15 55.9 0.0 8e-15 54.8 0.0 1.9 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EMC81220.1 - 1.5e-06 28.4 0.0 3.3e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EMC81220.1 - 0.00058 20.2 0.5 0.0044 17.3 0.5 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF4032 PF13224.6 EMC81220.1 - 0.11 12.4 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4032) ATPase_2 PF01637.18 EMC81220.1 - 0.22 11.4 0.0 0.3 11.0 0.0 1.1 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Ski_Sno PF02437.17 EMC81221.1 - 4e-40 135.9 0.2 6.3e-40 135.3 0.2 1.3 1 0 0 1 1 1 1 SKI/SNO/DAC family c-SKI_SMAD_bind PF08782.10 EMC81221.1 - 1.8e-27 95.4 4.2 1.8e-27 95.4 4.2 2.0 2 0 0 2 2 2 1 c-SKI Smad4 binding domain Jas PF16135.5 EMC81221.1 - 0.12 12.6 2.7 0.13 12.5 1.0 1.9 2 0 0 2 2 2 0 TPL-binding domain in jasmonate signalling MH2 PF03166.14 EMC81222.1 - 1.1e-79 267.0 0.1 1.7e-79 266.4 0.1 1.3 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.16 EMC81222.1 - 1.9e-43 146.9 2.0 3.5e-43 146.0 2.0 1.4 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.9 EMC81222.1 - 0.0055 16.5 0.0 0.0096 15.7 0.0 1.4 1 0 0 1 1 1 1 Interferon-regulatory factor 3 BTB PF00651.31 EMC81223.1 - 3.2e-33 114.3 1.3 2.1e-32 111.7 0.5 2.2 2 0 0 2 2 2 1 BTB/POZ domain zf-H2C2_2 PF13465.6 EMC81223.1 - 7.3e-21 73.6 31.6 1.2e-08 35.0 1.0 5.3 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.26 EMC81223.1 - 8.5e-15 54.3 28.5 7.6e-05 23.0 1.4 5.1 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC81223.1 - 1.3e-13 50.5 24.3 0.0032 18.2 0.7 4.9 4 0 0 4 4 4 4 C2H2-type zinc finger CDC45 PF02724.14 EMC81223.1 - 0.0022 16.4 2.4 0.028 12.7 4.9 1.5 2 0 0 2 2 2 1 CDC45-like protein zf-met PF12874.7 EMC81223.1 - 0.0072 16.7 20.2 0.08 13.4 0.4 4.7 4 0 0 4 4 4 1 Zinc-finger of C2H2 type zinc_ribbon_9 PF14369.6 EMC81223.1 - 0.017 15.4 0.9 1.1 9.6 0.0 3.5 3 0 0 3 3 3 0 zinc-ribbon RXT2_N PF08595.11 EMC81223.1 - 0.047 13.7 3.9 0.088 12.8 3.9 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal zf-C2H2_6 PF13912.6 EMC81223.1 - 0.064 13.3 0.1 0.064 13.3 0.1 4.9 5 0 0 5 5 4 0 C2H2-type zinc finger DUF3268 PF11672.8 EMC81223.1 - 0.072 13.4 1.5 0.58 10.5 0.9 2.4 2 0 0 2 2 2 0 zinc-finger-containing domain Mif2_N PF15624.6 EMC81223.1 - 0.18 12.5 1.4 0.38 11.4 1.4 1.5 1 0 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal zf-H2C2_5 PF13909.6 EMC81223.1 - 0.22 11.3 25.2 2.3 8.1 1.8 4.7 4 0 0 4 4 4 0 C2H2-type zinc-finger domain BUD22 PF09073.10 EMC81223.1 - 0.27 10.6 8.2 0.36 10.1 8.2 1.2 1 0 0 1 1 1 0 BUD22 GAGA PF09237.11 EMC81223.1 - 0.28 11.0 6.5 0.55 10.1 0.1 3.5 1 1 3 4 4 4 0 GAGA factor zf-C2H2_jaz PF12171.8 EMC81223.1 - 0.41 11.0 23.8 0.25 11.7 1.4 5.4 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding DUF2457 PF10446.9 EMC81223.1 - 0.6 9.2 18.7 1 8.5 18.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PI3K_1B_p101 PF10486.9 EMC81223.1 - 0.65 7.7 5.1 0.91 7.2 5.1 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit FAM176 PF14851.6 EMC81223.1 - 0.69 9.6 9.8 1.6 8.4 9.8 1.5 1 0 0 1 1 1 0 FAM176 family TFB6 PF17110.5 EMC81223.1 - 0.73 9.6 5.5 1.3 8.8 5.5 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH CobT PF06213.12 EMC81223.1 - 0.89 8.9 12.6 1.4 8.3 12.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SDA1 PF05285.12 EMC81223.1 - 0.94 8.8 13.8 1.5 8.2 13.8 1.2 1 0 0 1 1 1 0 SDA1 PDDEXK_6 PF04720.12 EMC81223.1 - 1.1 9.2 3.8 2.1 8.2 3.8 1.4 1 0 0 1 1 1 0 PDDEXK-like family of unknown function zf-C2H2_2 PF12756.7 EMC81223.1 - 1.5 9.2 18.8 6.1 7.2 0.8 4.5 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) Nop14 PF04147.12 EMC81223.1 - 1.6 6.9 16.4 2.3 6.3 16.4 1.1 1 0 0 1 1 1 0 Nop14-like family TRAP_alpha PF03896.16 EMC81223.1 - 2.5 7.2 8.5 4.2 6.5 8.5 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF2722 PF10846.8 EMC81223.1 - 2.7 6.9 7.1 3.7 6.4 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) PTPRCAP PF15713.5 EMC81223.1 - 2.7 8.3 15.7 5.6 7.2 15.7 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated zf-C2H2_9 PF16293.5 EMC81223.1 - 2.7 7.9 9.6 19 5.2 0.1 4.3 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) Sporozoite_P67 PF05642.11 EMC81223.1 - 2.8 5.9 6.9 3.8 5.5 6.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RRN3 PF05327.11 EMC81223.1 - 6.8 5.1 12.8 9.7 4.6 12.8 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Afi1 PF07792.12 EMC81224.1 - 0.011 16.2 1.5 0.011 16.2 1.5 2.5 1 1 1 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Fmp27 PF10344.9 EMC81224.1 - 0.056 11.5 1.2 0.08 11.0 1.2 1.2 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 SRP-alpha_N PF04086.13 EMC81224.1 - 0.31 10.9 28.9 0.37 10.7 28.9 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal OATP PF03137.20 EMC81225.1 - 1.2e-89 301.1 13.6 1.2e-89 301.1 13.6 1.4 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family Kazal_2 PF07648.15 EMC81225.1 - 1.7e-08 34.5 9.1 2.6e-08 33.8 8.2 1.9 1 1 0 1 1 1 1 Kazal-type serine protease inhibitor domain MFS_1 PF07690.16 EMC81225.1 - 2.6e-06 26.6 14.7 0.0055 15.7 8.0 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily Kazal_1 PF00050.21 EMC81225.1 - 0.00029 20.8 5.3 0.00064 19.7 4.9 1.8 1 1 0 1 1 1 1 Kazal-type serine protease inhibitor domain EMP70 PF02990.16 EMC81225.1 - 0.35 9.5 2.0 1.8 7.1 2.8 1.7 2 0 0 2 2 2 0 Endomembrane protein 70 Ac110_PIF PF07280.11 EMC81226.1 - 0.026 14.3 0.3 0.026 14.3 0.3 1.6 2 0 0 2 2 2 0 Per os infectivity factor AC110 CrgA PF06781.12 EMC81226.1 - 0.042 13.9 0.0 0.058 13.5 0.0 1.2 1 0 0 1 1 1 0 Cell division protein CrgA Amnionless PF14828.6 EMC81226.1 - 0.2 10.4 0.0 0.22 10.3 0.0 1.0 1 0 0 1 1 1 0 Amnionless Neurensin PF14927.6 EMC81226.1 - 6.9 6.4 5.2 13 5.5 2.9 2.0 1 1 1 2 2 2 0 Neurensin PGM_PMM_I PF02878.16 EMC81227.1 - 6.1e-29 100.5 0.0 1.7e-28 99.1 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 EMC81227.1 - 3.4e-26 91.9 0.0 7.9e-25 87.5 0.0 2.4 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EMC81227.1 - 4.2e-14 52.7 0.2 1e-13 51.5 0.1 1.8 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 EMC81227.1 - 1.6e-07 31.4 0.1 1e-06 28.8 0.0 2.4 3 0 0 3 3 3 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain NARG2_C PF10505.9 EMC81229.1 - 3.1e-76 255.6 0.1 6.4e-76 254.6 0.1 1.6 1 0 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus PAC4 PF16093.5 EMC81229.1 - 0.11 12.7 0.1 0.58 10.4 0.0 2.3 2 0 0 2 2 2 0 Proteasome assembly chaperone 4 Annexin PF00191.20 EMC81230.1 - 5.4e-88 289.1 8.7 1.2e-26 92.5 0.5 4.1 4 0 0 4 4 4 4 Annexin Forkhead PF00250.18 EMC81231.1 - 1.4e-37 127.8 0.1 1.9e-37 127.4 0.1 1.2 1 0 0 1 1 1 1 Forkhead domain BNIP2 PF12496.8 EMC81232.1 - 1.5e-34 119.3 2.1 2.7e-34 118.5 2.1 1.4 1 0 0 1 1 1 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO_2 PF13716.6 EMC81232.1 - 1.3e-31 109.6 0.3 1.8e-31 109.2 0.3 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 EMC81232.1 - 1.6e-08 34.5 0.0 2.4e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain DUF2810 PF10928.8 EMC81232.1 - 0.17 12.0 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2810) TFIIA_gamma_N PF02268.16 EMC81233.1 - 7.9e-24 83.4 0.4 1.1e-23 82.9 0.4 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TFIIA_gamma_C PF02751.14 EMC81233.1 - 1.7e-22 79.2 2.7 2.5e-22 78.7 2.7 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit Branch PF02485.21 EMC81234.1 - 2.2e-61 207.5 0.0 2.6e-61 207.2 0.0 1.1 1 0 0 1 1 1 1 Core-2/I-Branching enzyme OTU PF02338.19 EMC81235.1 - 1.5e-23 83.6 0.0 3.2e-23 82.6 0.0 1.6 1 0 0 1 1 1 1 OTU-like cysteine protease zf-A20 PF01754.16 EMC81235.1 - 1.4e-07 31.3 9.8 2.5e-07 30.5 9.8 1.5 1 0 0 1 1 1 1 A20-like zinc finger UBA_4 PF14555.6 EMC81235.1 - 8.8e-05 22.2 0.0 0.00016 21.4 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 EMC81235.1 - 0.0066 16.1 0.0 0.015 14.9 0.0 1.6 1 0 0 1 1 1 1 TAP C-terminal domain zf-C2H2 PF00096.26 EMC81236.1 - 1.9e-15 56.3 20.4 3.7e-05 23.9 0.5 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC81236.1 - 1.6e-13 50.4 10.4 1.5e-07 31.6 1.2 4.6 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC81236.1 - 3e-09 36.9 21.1 0.0015 19.2 2.1 3.7 4 0 0 4 4 3 3 C2H2-type zinc finger FOXP-CC PF16159.5 EMC81236.1 - 0.0032 18.1 9.9 0.36 11.5 0.3 3.8 2 1 2 4 4 4 2 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 EMC81236.1 - 0.0069 16.7 6.5 0.018 15.3 5.6 2.0 1 1 1 2 2 2 1 C2H2-type zinc ribbon zf-met PF12874.7 EMC81236.1 - 0.013 15.8 9.6 1.3 9.5 0.3 4.2 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-BED PF02892.15 EMC81236.1 - 0.034 14.2 10.1 0.25 11.4 2.1 2.7 2 1 1 3 3 3 0 BED zinc finger zf-C2H2_aberr PF17017.5 EMC81236.1 - 0.34 11.0 6.8 1.5 8.9 0.2 2.3 1 1 0 2 2 2 0 Aberrant zinc-finger zf-Di19 PF05605.12 EMC81236.1 - 0.48 10.7 11.8 0.13 12.6 2.1 3.1 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding IBR PF01485.21 EMC81236.1 - 0.73 10.1 7.7 6.2 7.1 7.7 2.1 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain CHORD PF04968.12 EMC81236.1 - 1.9 9.3 10.7 2.9 8.7 5.2 2.5 1 1 1 2 2 2 0 CHORD zf-C2H2_jaz PF12171.8 EMC81236.1 - 2.6 8.5 18.2 5.4 7.4 0.3 3.9 4 0 0 4 4 3 0 Zinc-finger double-stranded RNA-binding LSDAT_euk PF18139.1 EMC81237.1 - 1.7e-122 408.0 0.0 2.4e-122 407.5 0.0 1.2 1 0 0 1 1 1 1 SLOG in TRPM TRPM_tetra PF16519.5 EMC81237.1 - 2.3e-24 85.2 5.8 2.3e-24 85.2 5.8 1.9 2 0 0 2 2 2 1 Tetramerisation domain of TRPM Ion_trans PF00520.31 EMC81237.1 - 5.4e-20 71.7 16.1 8.8e-20 71.0 16.1 1.3 1 0 0 1 1 1 1 Ion transport protein LSDAT_prok PF18171.1 EMC81237.1 - 3.3e-17 62.4 0.0 5.7e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote Myotub-related PF06602.14 EMC81238.1 - 2.9e-69 233.7 6.3 3.6e-57 193.9 3.0 2.1 1 1 1 2 2 2 2 Myotubularin-like phosphatase domain 3-PAP PF12578.8 EMC81238.1 - 5.1e-58 194.5 0.2 9e-58 193.7 0.2 1.4 1 0 0 1 1 1 1 Myotubularin-associated protein VRR_NUC PF08774.11 EMC81239.1 - 3.2e-25 88.3 0.0 6.7e-25 87.3 0.0 1.5 1 0 0 1 1 1 1 VRR-NUC domain Utp12 PF04003.12 EMC81239.1 - 0.089 13.1 0.2 0.89 9.9 0.0 2.4 2 0 0 2 2 2 0 Dip2/Utp12 Family TPR_12 PF13424.6 EMC81239.1 - 0.16 12.2 2.7 9 6.7 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Mpp10 PF04006.12 EMC81240.1 - 2.8e-205 683.4 90.5 3.4e-205 683.1 90.5 1.1 1 0 0 1 1 1 1 Mpp10 protein RisS_PPD PF16524.5 EMC81240.1 - 0.17 12.2 2.9 6.8 7.0 2.9 3.3 1 1 0 1 1 1 0 Periplasmic domain of Sensor histidine kinase RisS Glyoxalase_4 PF13669.6 EMC81241.1 - 2.4e-22 79.3 0.0 2.9e-22 79.0 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.25 EMC81241.1 - 8.7e-12 45.3 0.0 1e-11 45.1 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 EMC81241.1 - 2.1e-08 34.5 0.0 2.5e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 EMC81241.1 - 0.00027 20.8 0.0 0.00052 19.9 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 EMC81241.1 - 0.21 12.4 0.0 0.31 11.9 0.0 1.2 1 0 0 1 1 1 0 Glyoxalase-like domain DUF1338 PF07063.13 EMC81241.1 - 0.22 10.7 0.0 2.6 7.2 0.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF1338) Myco_arth_vir_N PF09610.10 EMC81241.1 - 1.1 9.4 4.5 0.54 10.4 1.6 2.0 2 0 0 2 2 2 0 Mycoplasma virulence signal region (Myco_arth_vir_N) PID PF00640.23 EMC81242.1 - 1.6e-51 174.0 2.3 1.6e-51 174.0 2.3 2.4 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) PDZ PF00595.24 EMC81242.1 - 5.2e-27 94.0 10.9 1.7e-13 50.7 0.9 2.8 3 0 0 3 3 3 2 PDZ domain PDZ_6 PF17820.1 EMC81242.1 - 3.3e-15 55.7 2.3 9.6e-08 31.8 0.1 2.9 3 0 0 3 3 3 2 PDZ domain PDZ_2 PF13180.6 EMC81242.1 - 1.2e-05 25.5 0.1 0.0017 18.6 0.0 2.6 2 0 0 2 2 2 1 PDZ domain NRho PF16733.5 EMC81242.1 - 0.083 13.0 1.4 0.21 11.7 0.1 2.3 3 0 0 3 3 3 0 Rhomboid N-terminal domain CD20 PF04103.15 EMC81243.1 - 5.9e-12 46.0 12.3 1.3e-11 44.8 12.3 1.6 1 0 0 1 1 1 1 CD20-like family PDZ PF00595.24 EMC81244.1 - 1.1e-46 157.1 7.2 3.5e-15 56.1 0.1 3.5 3 0 0 3 3 3 3 PDZ domain ZU5 PF00791.20 EMC81244.1 - 1.9e-36 124.3 0.0 5.9e-36 122.8 0.0 1.9 2 0 0 2 2 2 1 ZU5 domain PDZ_6 PF17820.1 EMC81244.1 - 2.5e-24 84.9 2.4 3.6e-09 36.3 0.1 3.5 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 EMC81244.1 - 3.6e-16 59.3 3.8 8.2e-05 22.9 0.1 3.6 3 0 0 3 3 3 3 PDZ domain Guanylate_kin PF00625.21 EMC81244.1 - 1.5e-12 47.5 0.0 2.9e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 Guanylate kinase SH3_2 PF07653.17 EMC81244.1 - 4.7e-11 42.2 0.1 1.2e-10 40.9 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC81244.1 - 0.0024 17.5 0.1 0.021 14.4 0.0 2.6 2 0 0 2 2 2 1 SH3 domain RPOL_N PF14700.6 EMC81244.1 - 0.048 13.1 1.9 0.34 10.3 0.1 2.5 2 0 0 2 2 2 0 DNA-directed RNA polymerase N-terminal tRNA-synt_2b PF00587.25 EMC81245.1 - 2.8e-36 125.2 0.0 4.7e-36 124.4 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EMC81245.1 - 3.1e-21 75.3 0.1 7.4e-21 74.1 0.1 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 EMC81245.1 - 7e-14 51.7 0.0 1.6e-13 50.5 0.0 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 EMC81245.1 - 1.3e-12 47.5 0.0 2.8e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 TGS domain TM2 PF05154.16 EMC81246.1 - 8.7e-15 54.8 7.9 1.4e-14 54.1 7.9 1.3 1 0 0 1 1 1 1 TM2 domain A_deaminase PF00962.22 EMC81247.1 - 4.1e-37 128.2 0.0 4.8e-37 128.0 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase Amidohydro_1 PF01979.20 EMC81247.1 - 0.046 13.0 0.0 0.082 12.2 0.0 1.3 1 1 0 1 1 1 0 Amidohydrolase family GAIN PF16489.5 EMC81247.1 - 0.11 11.9 0.1 0.2 11.0 0.1 1.4 1 0 0 1 1 1 0 GPCR-Autoproteolysis INducing (GAIN) domain La PF05383.17 EMC81248.1 - 1.2e-21 76.5 0.2 2.8e-21 75.3 0.2 1.6 1 0 0 1 1 1 1 La domain SUZ-C PF12901.7 EMC81248.1 - 3.6e-07 30.1 0.0 7.1e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 SUZ-C motif LRR_9 PF14580.6 EMC81249.1 - 2.1e-24 86.0 17.3 9.5e-16 57.8 2.6 3.9 2 1 1 3 3 3 3 Leucine-rich repeat LRR_4 PF12799.7 EMC81249.1 - 2.7e-22 78.5 41.7 1.6e-08 34.7 5.2 6.0 5 1 1 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMC81249.1 - 7.5e-13 48.0 44.1 3.6e-07 29.8 10.8 6.5 5 1 3 8 8 8 5 Leucine rich repeat DUF2322 PF10084.9 EMC81249.1 - 1 9.5 4.0 8.4 6.5 0.3 3.4 3 1 2 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2322) UB2H PF14814.6 EMC81249.1 - 4.8 7.3 6.3 2e+02 2.1 0.1 5.0 4 1 1 5 5 5 0 Bifunctional transglycosylase second domain Neur_chan_LBD PF02931.23 EMC81250.1 - 3e-73 245.9 1.0 3.9e-73 245.5 1.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC81250.1 - 3.4e-65 220.4 0.0 4.3e-65 220.1 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region SUR7 PF06687.12 EMC81250.1 - 0.12 12.0 0.0 0.12 12.0 0.0 2.1 2 0 0 2 2 2 0 SUR7/PalI family DUF2417 PF10329.9 EMC81250.1 - 2.6 7.4 5.6 1 8.7 2.7 1.7 2 0 0 2 2 2 0 Region of unknown function (DUF2417) tRNA_bind_3 PF17176.4 EMC81251.1 - 0.014 15.7 3.4 0.025 14.9 0.1 3.0 2 1 0 3 3 3 0 tRNA-binding domain Apolipoprotein PF01442.18 EMC81251.1 - 0.82 9.5 30.1 2.9 7.7 20.3 3.2 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.12 EMC81251.1 - 1.6 8.8 21.3 1.5 8.9 0.6 4.1 2 2 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Myosin_head PF00063.21 EMC81252.1 - 2.7e-251 835.6 5.6 3.5e-251 835.2 5.6 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EMC81252.1 - 2.3e-55 187.2 1.7 4.6e-55 186.2 1.7 1.6 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 EMC81252.1 - 4.6e-17 61.3 0.3 1.8e-16 59.4 0.1 2.1 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EMC81252.1 - 1.2e-15 57.1 0.1 3.9e-15 55.4 0.1 2.0 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC81252.1 - 6.5e-12 44.9 0.0 1.5e-11 43.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain IQ PF00612.27 EMC81252.1 - 0.0083 15.8 2.2 0.024 14.4 2.2 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif AAA_16 PF13191.6 EMC81252.1 - 0.0084 16.5 0.0 0.059 13.8 0.0 2.4 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EMC81252.1 - 0.042 14.1 0.1 0.15 12.4 0.1 1.9 1 0 0 1 1 1 0 AAA domain Microtub_bd PF16796.5 EMC81252.1 - 0.049 13.6 0.3 0.21 11.5 0.0 2.1 2 0 0 2 2 2 0 Microtubule binding ABC_tran PF00005.27 EMC81252.1 - 0.1 13.1 0.1 0.42 11.1 0.0 2.0 2 0 0 2 2 2 0 ABC transporter Sigma54_activat PF00158.26 EMC81252.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Cyclin_N PF00134.23 EMC81253.1 - 2.4e-40 137.2 1.5 8.6e-40 135.4 0.1 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EMC81253.1 - 1.1e-32 112.6 2.4 1.8e-32 111.9 1.3 1.9 2 0 0 2 2 2 1 Cyclin, C-terminal domain RNF111_N PF15303.6 EMC81254.1 - 1.1e-128 428.9 21.7 1.1e-128 428.9 21.7 2.4 2 1 0 2 2 1 1 E3 ubiquitin-protein ligase Arkadia N-terminus zf-RING_2 PF13639.6 EMC81254.1 - 7.6e-13 48.6 6.8 7.6e-13 48.6 6.8 3.3 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC81254.1 - 4.5e-09 36.0 6.6 4.5e-09 36.0 6.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EMC81254.1 - 8.2e-08 31.9 2.6 8.2e-08 31.9 2.6 2.7 3 0 0 3 3 3 1 RING-like zinc finger zf-rbx1 PF12678.7 EMC81254.1 - 3.5e-07 30.4 4.1 3.5e-07 30.4 4.1 2.9 3 0 0 3 3 2 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EMC81254.1 - 9.5e-07 28.6 4.5 2.5e-06 27.2 4.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC81254.1 - 1.8e-06 27.7 5.9 1.8e-06 27.7 5.9 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC81254.1 - 3.2e-05 23.8 3.8 3.2e-05 23.8 3.8 2.5 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC81254.1 - 0.00029 20.6 4.6 0.00029 20.6 4.6 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EMC81254.1 - 0.067 13.3 5.8 0.14 12.2 3.9 2.6 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EMC81254.1 - 0.097 12.3 6.1 0.068 12.8 3.4 2.2 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type RINGv PF12906.7 EMC81254.1 - 0.57 10.4 6.6 2.2 8.5 6.5 2.2 1 1 0 1 1 1 0 RING-variant domain RRM_1 PF00076.22 EMC81255.1 - 2.4e-11 43.3 0.0 4.7e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMC81255.1 - 1.6e-08 34.2 0.0 4e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MINDY_DUB PF04424.13 EMC81256.1 - 6.6e-37 126.1 1.7 1.1e-36 125.4 0.0 2.0 2 0 0 2 2 2 1 MINDY deubiquitinase gpW PF02831.15 EMC81256.1 - 0.058 13.3 0.0 0.18 11.7 0.0 1.8 1 0 0 1 1 1 0 gpW Phage_ABA_S PF18066.1 EMC81256.1 - 0.14 12.9 0.1 0.48 11.2 0.0 1.9 2 0 0 2 2 2 0 Phage ABA sandwich domain CCDC50_N PF15295.6 EMC81256.1 - 1.3 9.2 14.8 3.5 7.8 14.8 1.8 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus Ribosomal_60s PF00428.19 EMC81256.1 - 9.6 6.9 6.8 22 5.7 6.8 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Lipase PF00151.19 EMC81257.1 - 4.8e-122 407.5 0.1 6.4e-122 407.0 0.1 1.2 1 0 0 1 1 1 1 Lipase PLAT PF01477.23 EMC81257.1 - 2.2e-23 83.0 1.8 3.1e-23 82.6 0.8 1.8 2 0 0 2 2 2 1 PLAT/LH2 domain Abhydrolase_6 PF12697.7 EMC81257.1 - 6.7e-05 23.6 0.2 9.2e-05 23.1 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EMC81257.1 - 0.0015 18.2 0.1 0.0024 17.5 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold MIP PF00230.20 EMC81258.1 - 5.1e-51 173.6 13.4 6.4e-51 173.2 13.4 1.0 1 0 0 1 1 1 1 Major intrinsic protein Aldedh PF00171.22 EMC81259.1 - 9.7e-180 598.0 0.0 1.1e-179 597.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EMC81259.1 - 0.014 14.9 0.1 4 6.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) LuxC PF05893.14 EMC81259.1 - 0.18 10.8 0.0 11 4.9 0.0 2.1 2 0 0 2 2 2 0 Acyl-CoA reductase (LuxC) SlyX PF04102.12 EMC81260.1 - 0.00083 19.9 2.9 0.00083 19.9 2.9 6.9 3 2 3 7 7 7 1 SlyX BLOC1_2 PF10046.9 EMC81260.1 - 0.014 15.6 5.4 0.014 15.6 5.4 5.0 2 1 3 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4349 PF14257.6 EMC81260.1 - 1.1 8.6 30.4 0.22 10.9 14.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4349) PUMA PF15826.5 EMC81260.1 - 2.1 8.5 4.7 0.47 10.6 0.5 2.0 2 0 0 2 2 2 0 Bcl-2-binding component 3, p53 upregulated modulator of apoptosis Myosin_tail_1 PF01576.19 EMC81261.1 - 1.1e-51 175.8 184.6 2.7e-35 121.6 53.3 2.4 1 1 1 2 2 2 2 Myosin tail CALCOCO1 PF07888.11 EMC81261.1 - 0.0026 16.7 46.0 0.0026 16.7 46.0 4.7 1 1 3 4 4 4 1 Calcium binding and coiled-coil domain (CALCOCO1) like Filament PF00038.21 EMC81261.1 - 0.11 12.0 162.2 0.18 11.4 26.2 6.7 1 1 3 5 5 5 0 Intermediate filament protein HLH PF00010.26 EMC81262.1 - 1.7e-10 40.7 1.5 1.3e-09 37.8 1.4 2.2 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain CDC45 PF02724.14 EMC81262.1 - 1 7.5 6.2 1.4 7.1 6.2 1.1 1 0 0 1 1 1 0 CDC45-like protein PRKG1_interact PF15898.5 EMC81263.1 - 0.0015 19.4 18.8 0.0015 19.4 18.8 2.8 1 1 1 2 2 2 1 cGMP-dependent protein kinase interacting domain Macoilin PF09726.9 EMC81263.1 - 0.052 12.1 26.3 0.066 11.8 26.3 1.1 1 0 0 1 1 1 0 Macoilin family Fez1 PF06818.15 EMC81263.1 - 0.077 13.5 30.9 0.13 12.7 30.9 1.4 1 0 0 1 1 1 0 Fez1 Rx_N PF18052.1 EMC81263.1 - 0.4 11.0 16.2 0.48 10.7 4.6 3.6 2 1 1 3 3 3 0 Rx N-terminal domain DUF763 PF05559.11 EMC81263.1 - 1.3 8.2 7.4 1.8 7.6 7.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF763) GAS PF13851.6 EMC81263.1 - 1.4 8.2 38.7 0.36 10.1 21.7 2.8 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF745 PF05335.13 EMC81263.1 - 2.6 7.7 26.9 0.57 9.9 13.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF745) FUSC PF04632.12 EMC81263.1 - 5.1 5.5 6.6 6.3 5.2 6.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family ERM PF00769.19 EMC81263.1 - 5.3 6.8 38.0 11 5.7 38.0 1.5 1 1 0 1 1 1 0 Ezrin/radixin/moesin family DUF3450 PF11932.8 EMC81263.1 - 6.7 5.9 29.3 1.2 8.4 12.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF2259 PF10016.9 EMC81263.1 - 7 6.5 6.7 12 5.7 6.7 1.4 1 0 0 1 1 1 0 Predicted secreted protein (DUF2259) DUF2278 PF10042.9 EMC81263.1 - 9.9 6.1 7.5 19 5.2 6.1 1.8 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2278) DUF4111 PF13427.6 EMC81264.1 - 0.038 14.1 0.0 0.07 13.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4111) HECT PF00632.25 EMC81265.1 - 3.7e-101 338.7 0.1 5.6e-101 338.1 0.1 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 EMC81265.1 - 1.1e-47 159.7 24.0 3.7e-13 49.3 0.7 5.2 4 0 0 4 4 4 4 WW domain C2 PF00168.30 EMC81265.1 - 2.7e-23 82.2 0.0 6.8e-23 80.9 0.0 1.7 1 0 0 1 1 1 1 C2 domain 2OG-FeII_Oxy_4 PF13661.6 EMC81265.1 - 0.085 13.5 0.0 0.2 12.3 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily fn3 PF00041.21 EMC81266.1 - 3.6e-62 206.7 4.2 1.3e-11 44.7 0.1 5.6 5 0 0 5 5 5 5 Fibronectin type III domain I-set PF07679.16 EMC81266.1 - 1.2e-56 188.7 0.0 2.4e-15 56.3 0.0 5.7 5 0 0 5 5 5 4 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC81266.1 - 1.5e-55 185.7 2.0 1.5e-13 51.1 0.0 5.0 5 0 0 5 5 4 4 Immunoglobulin domain ig PF00047.25 EMC81266.1 - 7.2e-34 115.8 0.0 4.9e-07 29.8 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 EMC81266.1 - 4.1e-32 110.3 0.2 4.1e-08 33.4 0.0 5.1 5 0 0 5 5 5 4 Immunoglobulin domain V-set PF07686.17 EMC81266.1 - 1.3e-16 60.7 6.3 0.17 12.1 0.0 8.7 5 4 3 8 8 8 4 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.5 EMC81266.1 - 8.3e-14 51.9 6.8 0.0019 18.7 0.1 6.2 5 1 0 5 5 5 3 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.12 EMC81266.1 - 8.4e-11 41.8 0.4 0.033 14.2 0.0 4.5 4 0 0 4 4 4 3 CD80-like C2-set immunoglobulin domain fn3_2 PF16893.5 EMC81266.1 - 1.1e-07 31.9 0.1 0.0097 16.0 0.0 4.4 5 0 0 5 5 5 2 Fibronectin type III domain Ig_6 PF18452.1 EMC81266.1 - 7.9e-06 25.4 0.0 0.05 13.2 0.0 4.0 4 0 0 4 4 4 1 Immunoglobulin domain SusE PF14292.6 EMC81266.1 - 1.3e-05 25.4 0.3 0.7 10.2 0.0 4.8 4 0 0 4 4 4 1 SusE outer membrane protein Ig_4 PF16680.5 EMC81266.1 - 2.9e-05 24.2 0.1 0.57 10.5 0.0 4.2 4 1 0 4 4 3 1 T-cell surface glycoprotein CD3 delta chain C1-set PF07654.15 EMC81266.1 - 0.00057 20.2 0.3 0.13 12.6 0.0 4.5 6 0 0 6 6 5 1 Immunoglobulin C1-set domain fn3_4 PF16794.5 EMC81266.1 - 0.00074 19.4 2.3 0.052 13.5 0.0 4.4 5 0 0 5 5 5 1 Fibronectin-III type domain Izumo-Ig PF16706.5 EMC81266.1 - 0.0011 19.0 0.3 2.7 8.1 0.0 4.5 4 1 0 4 4 4 1 Izumo-like Immunoglobulin domain Ig_C17orf99 PF17736.1 EMC81266.1 - 0.0021 18.1 0.1 4.2 7.5 0.0 4.2 4 0 0 4 4 4 1 C17orf99 Ig domain Syndecan PF01034.20 EMC81266.1 - 0.0046 16.8 0.2 0.089 12.7 0.9 2.3 2 0 0 2 2 2 1 Syndecan domain DUF2369 PF10179.9 EMC81266.1 - 0.0048 17.2 0.0 25 5.4 0.0 5.0 5 0 0 5 5 5 0 Uncharacterised conserved protein (DUF2369) Adeno_E3_CR2 PF02439.15 EMC81266.1 - 0.015 15.0 3.9 0.034 13.9 3.9 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 PRIMA1 PF16101.5 EMC81266.1 - 0.088 12.8 0.4 12 5.9 0.2 2.5 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 AGTRAP PF06396.11 EMC81266.1 - 0.12 12.1 0.1 0.33 10.8 0.0 1.7 2 0 0 2 2 1 0 Angiotensin II, type I receptor-associated protein (AGTRAP) RasGAP PF00616.19 EMC81267.1 - 6.1e-60 202.5 3.2 6.7e-60 202.4 0.0 2.6 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 EMC81267.1 - 2.7e-37 127.9 11.9 2.7e-37 127.9 11.9 3.3 3 0 0 3 3 3 1 RasGAP C-terminus IQ PF00612.27 EMC81267.1 - 2.9e-19 67.0 19.8 7e-06 25.4 0.6 5.3 5 0 0 5 5 5 4 IQ calmodulin-binding motif CH PF00307.31 EMC81267.1 - 3.6e-19 69.0 0.0 1.7e-18 66.8 0.0 2.3 1 0 0 1 1 1 1 Calponin homology (CH) domain WW PF00397.26 EMC81267.1 - 0.0028 17.7 4.2 0.0065 16.5 4.2 1.6 1 0 0 1 1 1 1 WW domain IDEAL PF08858.10 EMC81267.1 - 0.058 13.1 4.0 23 4.9 0.1 4.6 4 0 0 4 4 4 0 IDEAL domain Nif11 PF07862.11 EMC81267.1 - 0.072 13.4 1.6 6.1 7.2 0.1 3.6 2 0 0 2 2 2 0 Nif11 domain GCP_C_terminal PF04130.13 EMC81268.1 - 1.6e-61 208.5 12.0 1.7e-61 208.4 10.3 1.8 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EMC81268.1 - 1.1e-55 189.4 0.5 1.1e-55 189.4 0.5 1.7 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal DUF1720 PF08226.11 EMC81268.1 - 0.036 14.5 0.1 0.079 13.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1720) 53-BP1_Tudor PF09038.10 EMC81269.1 - 1.6e-75 250.9 0.2 2.9e-75 250.0 0.2 1.5 1 0 0 1 1 1 1 Tumour suppressor p53-binding protein-1 Tudor BRCT_3 PF18428.1 EMC81269.1 - 1.8e-39 133.9 0.0 3.5e-37 126.5 0.0 2.6 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain TUDOR_5 PF18359.1 EMC81269.1 - 1.6e-05 24.5 0.2 3.5e-05 23.4 0.2 1.5 1 0 0 1 1 1 1 Histone methyltransferase Tudor domain 1 BRCT_2 PF16589.5 EMC81269.1 - 0.00023 21.5 0.1 0.0024 18.3 0.0 2.4 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 EMC81269.1 - 0.00079 19.3 0.0 0.0019 18.0 0.0 1.6 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.26 EMC81269.1 - 0.0012 19.1 0.0 2.4 8.6 0.0 2.5 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain DUF4537 PF15057.6 EMC81269.1 - 0.0013 18.8 0.2 0.0059 16.6 0.0 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4537) His_Phos_2 PF00328.22 EMC81270.1 - 5.9e-125 417.6 0.0 1.1e-124 416.6 0.0 1.4 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 EMC81270.1 - 5.9e-41 138.5 0.3 1.3e-40 137.5 0.3 1.6 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 EMC81270.1 - 0.029 14.0 0.0 0.056 13.0 0.0 1.4 1 0 0 1 1 1 0 RimK-like ATP-grasp domain ATP-gua_Ptrans PF00217.19 EMC81271.1 - 4e-67 225.8 0.0 5e-67 225.5 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.15 EMC81271.1 - 1.8e-29 101.9 0.0 2.8e-29 101.3 0.0 1.3 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain Thioredoxin PF00085.20 EMC81272.1 - 1.1e-44 150.6 0.0 3.6e-31 107.2 0.0 3.4 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 EMC81272.1 - 4.3e-37 127.8 0.4 2.1e-33 115.8 0.5 2.8 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 EMC81272.1 - 1.6e-06 28.5 0.1 0.0021 18.5 0.1 3.3 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EMC81272.1 - 4.4e-05 23.7 0.0 0.0053 17.1 0.0 3.4 3 0 0 3 3 3 1 Thioredoxin-like Thioredoxin_4 PF13462.6 EMC81272.1 - 0.00021 21.5 0.1 0.045 13.9 0.0 3.2 3 0 0 3 3 3 1 Thioredoxin Calsequestrin PF01216.17 EMC81272.1 - 0.002 17.3 0.1 0.004 16.2 0.0 1.5 1 1 0 1 1 1 1 Calsequestrin Thioredoxin_7 PF13899.6 EMC81272.1 - 0.0098 16.1 0.0 0.027 14.7 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 EMC81272.1 - 0.023 14.6 0.1 0.12 12.3 0.0 2.1 2 0 0 2 2 2 0 AhpC/TSA family OST3_OST6 PF04756.13 EMC81272.1 - 0.073 12.4 0.0 0.26 10.6 0.0 1.9 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family Ras PF00071.22 EMC81273.1 - 6.7e-21 74.6 0.1 7.2e-21 74.5 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC81273.1 - 7.2e-17 61.7 0.1 7.8e-17 61.6 0.1 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EMC81273.1 - 1.4e-05 25.1 0.0 1.5e-05 25.1 0.0 1.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 EMC81273.1 - 0.00044 19.8 0.0 0.00046 19.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EMC81273.1 - 0.002 17.5 0.0 0.0022 17.4 0.0 1.0 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region VirE PF05272.11 EMC81273.1 - 0.004 16.9 0.0 0.0042 16.8 0.0 1.1 1 0 0 1 1 1 1 Virulence-associated protein E AAA_16 PF13191.6 EMC81273.1 - 0.012 16.0 0.1 0.014 15.8 0.1 1.2 1 1 0 1 1 1 0 AAA ATPase domain eIF-5a PF01287.20 EMC81273.1 - 0.013 15.6 0.0 0.014 15.5 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold DUF815 PF05673.13 EMC81273.1 - 0.014 14.5 0.0 0.014 14.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 EMC81273.1 - 0.031 13.8 0.0 0.034 13.7 0.0 1.1 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 EMC81273.1 - 0.036 13.6 0.0 0.04 13.5 0.0 1.1 1 0 0 1 1 1 0 AAA domain Septin PF00735.18 EMC81273.1 - 0.041 13.2 0.0 0.045 13.0 0.0 1.1 1 0 0 1 1 1 0 Septin AAA_14 PF13173.6 EMC81273.1 - 0.057 13.4 0.0 0.059 13.4 0.0 1.1 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.18 EMC81273.1 - 0.07 12.7 0.0 0.081 12.5 0.0 1.0 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_24 PF13479.6 EMC81273.1 - 0.084 12.6 0.0 0.084 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.10 EMC81273.1 - 0.12 11.8 0.0 0.13 11.7 0.0 1.0 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EMC81273.1 - 0.14 12.1 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 RsgA GTPase Pox_A32 PF04665.12 EMC81273.1 - 0.18 11.2 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein Serinc PF03348.15 EMC81274.1 - 3.1e-110 369.1 15.9 4.7e-105 352.0 11.7 2.0 2 0 0 2 2 2 2 Serine incorporator (Serinc) RPN6_C_helix PF18503.1 EMC81275.1 - 0.07 12.9 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 26S proteasome subunit RPN6 C-terminal helix domain MFAP1 PF06991.11 EMC81276.1 - 2.4e-78 262.9 31.1 2.4e-78 262.9 31.1 2.1 2 0 0 2 2 2 2 Microfibril-associated/Pre-mRNA processing Peptidase_S8 PF00082.22 EMC81277.1 - 4e-51 174.1 5.8 6e-51 173.5 5.8 1.3 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 EMC81277.1 - 2.8e-28 97.8 0.0 5.2e-28 96.9 0.0 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 EMC81277.1 - 5.4e-24 84.8 0.5 1.2e-23 83.6 0.5 1.6 1 0 0 1 1 1 1 Peptidase S8 pro-domain Furin-like_2 PF15913.5 EMC81277.1 - 0.00012 22.2 0.2 0.00012 22.2 0.2 2.0 2 0 0 2 2 2 1 Furin-like repeat, cysteine-rich VSP PF03302.13 EMC81277.1 - 0.021 13.7 10.4 0.34 9.7 0.7 2.4 2 0 0 2 2 2 0 Giardia variant-specific surface protein DUF357 PF04010.13 EMC81277.1 - 0.037 14.1 0.2 0.085 12.9 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF357) GF_recep_IV PF14843.6 EMC81277.1 - 0.72 9.6 22.1 0.14 12.0 16.1 2.5 2 1 0 2 2 2 0 Growth factor receptor domain IV RCC1 PF00415.18 EMC81278.1 - 2.3e-07 31.3 0.0 2.6e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat Sec1 PF00995.23 EMC81279.1 - 1.6e-92 311.6 0.0 1.8e-92 311.5 0.0 1.0 1 0 0 1 1 1 1 Sec1 family DUF4269 PF14091.6 EMC81279.1 - 0.13 12.5 0.8 2.4 8.4 0.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4269) TTL PF03133.15 EMC81280.1 - 9e-88 294.2 0.2 1.6e-87 293.4 0.2 1.3 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EMC81280.1 - 2.6e-09 36.7 0.0 0.00013 21.3 0.0 3.4 2 1 1 3 3 3 3 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 EMC81280.1 - 1.1e-05 24.9 0.0 0.028 13.7 0.0 3.0 3 0 0 3 3 3 2 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 EMC81280.1 - 0.0025 17.9 0.0 0.0093 16.0 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain EF-hand_7 PF13499.6 EMC81281.1 - 4.7e-14 52.6 5.1 2.1e-12 47.3 2.6 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EMC81281.1 - 7.3e-12 44.0 8.4 3.3e-05 23.1 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 EMC81281.1 - 8.5e-12 44.0 4.7 2.8e-05 23.7 0.6 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 EMC81281.1 - 7.4e-08 32.1 6.8 0.0018 18.1 3.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EMC81281.1 - 4.2e-07 29.2 3.7 0.0092 15.4 0.6 2.6 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 EMC81281.1 - 4.6e-05 23.7 0.7 0.00038 20.8 0.7 2.1 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EMC81281.1 - 0.0015 18.4 4.4 0.094 12.7 0.2 2.7 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 EMC81281.1 - 0.0022 18.2 0.5 0.0057 16.8 0.5 1.7 1 1 0 1 1 1 1 Dockerin type I domain EF-hand_9 PF14658.6 EMC81281.1 - 0.011 16.1 0.9 0.12 12.7 0.1 2.6 2 1 0 2 2 2 0 EF-hand domain NuiA PF07924.11 EMC81281.1 - 0.03 14.7 0.0 0.045 14.1 0.0 1.2 1 0 0 1 1 1 0 Nuclease A inhibitor-like protein Gal4_dimer PF03902.13 EMC81281.1 - 0.086 13.0 4.2 0.17 12.0 0.4 2.4 1 1 1 2 2 2 0 Gal4-like dimerisation domain Iso_dh PF00180.20 EMC81282.1 - 1.4e-73 248.0 0.0 3.5e-73 246.8 0.0 1.5 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Phe_ZIP PF08916.11 EMC81282.1 - 0.2 12.4 1.0 0.74 10.6 0.4 2.1 2 0 0 2 2 2 0 Phenylalanine zipper Clat_adaptor_s PF01217.20 EMC81283.1 - 1.2e-40 138.8 3.2 1.4e-40 138.5 3.2 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Peptidase_M1_N PF17900.1 EMC81284.1 - 2.7e-56 190.7 0.2 4.1e-56 190.1 0.2 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain DUF5557 PF17712.1 EMC81284.1 - 0.046 13.6 0.1 0.098 12.6 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5557) EMP24_GP25L PF01105.24 EMC81285.1 - 1.1e-30 107.0 0.4 1.2e-30 106.8 0.4 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD GOLD_2 PF13897.6 EMC81285.1 - 0.014 15.9 0.1 0.023 15.2 0.1 1.4 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Pec_lyase PF09492.10 EMC81285.1 - 0.085 12.2 0.0 4 6.7 0.0 2.0 1 1 1 2 2 2 0 Pectic acid lyase Ank_2 PF12796.7 EMC81286.1 - 3.2e-16 59.7 0.5 6.9e-14 52.2 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC81286.1 - 1.3e-15 57.5 0.4 7.9e-06 26.3 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EMC81286.1 - 4.9e-14 52.0 2.3 7.7e-06 26.1 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EMC81286.1 - 3e-13 49.7 1.9 6.8e-07 29.5 0.1 3.8 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC81286.1 - 2.6e-12 45.7 0.3 0.0021 18.4 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat DUF2000 PF09391.10 EMC81286.1 - 0.079 12.9 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2000) FMN_dh PF01070.18 EMC81286.1 - 0.081 11.9 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 FMN-dependent dehydrogenase Peptidase_C1 PF00112.23 EMC81287.1 - 2.3e-77 260.0 0.2 2.7e-77 259.7 0.2 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EMC81287.1 - 5.7e-05 22.1 0.3 0.022 13.5 0.0 2.2 2 0 0 2 2 2 2 Peptidase C1-like family WD40 PF00400.32 EMC81288.1 - 0.00047 20.9 1.1 1.7 9.6 0.0 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat Nup160 PF11715.8 EMC81288.1 - 0.1 11.2 0.4 0.18 10.4 0.1 1.4 2 0 0 2 2 2 0 Nucleoporin Nup120/160 NIF PF03031.18 EMC81290.1 - 1.3e-55 187.5 1.1 2.6e-55 186.5 1.1 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase FeS_assembly_P PF01883.19 EMC81291.1 - 1e-06 28.8 0.0 1.7e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein MRG PF05712.13 EMC81292.1 - 4.9e-39 133.7 0.1 9.5e-39 132.8 0.1 1.5 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 EMC81292.1 - 1.1e-15 57.3 0.4 2.7e-15 56.0 0.4 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Ank_2 PF12796.7 EMC81293.1 - 3.7e-38 130.0 10.8 5.3e-13 49.4 1.9 4.4 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC81293.1 - 9.1e-26 89.9 2.1 5.5e-07 30.0 0.4 5.6 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC81293.1 - 5e-24 84.1 5.1 1.3e-05 25.4 0.3 4.8 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EMC81293.1 - 7.3e-22 76.8 7.4 0.00025 21.4 0.0 5.6 5 0 0 5 5 5 5 Ankyrin repeat Ank_3 PF13606.6 EMC81293.1 - 1.1e-21 74.6 0.5 0.0054 17.1 0.0 6.6 6 0 0 6 6 6 5 Ankyrin repeat Seryl_tRNA_N PF02403.22 EMC81293.1 - 0.0023 18.1 9.3 0.0023 18.1 9.3 13.8 3 2 13 17 17 17 2 Seryl-tRNA synthetase N-terminal domain TLE_N PF03920.15 EMC81294.1 - 3.8e-35 120.8 8.8 5.4e-35 120.3 8.8 1.2 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain WD40 PF00400.32 EMC81294.1 - 3.8e-13 49.7 12.5 0.014 16.2 1.3 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC81294.1 - 2.3e-06 27.8 0.0 0.47 10.8 0.0 4.1 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EMC81294.1 - 0.0036 16.7 0.0 2.2 7.6 0.0 2.5 2 1 1 3 3 3 2 WD40-like domain Cytochrom_D1 PF02239.16 EMC81294.1 - 0.049 12.1 0.0 2.2 6.7 0.0 2.2 2 0 0 2 2 2 0 Cytochrome D1 heme domain Ribosomal_S18 PF01084.20 EMC81294.1 - 0.16 12.2 0.6 0.28 11.4 0.6 1.4 1 0 0 1 1 1 0 Ribosomal protein S18 HlyIII PF03006.20 EMC81296.1 - 6.6e-41 140.5 13.8 1e-40 139.9 13.8 1.2 1 0 0 1 1 1 1 Haemolysin-III related Kinesin PF00225.23 EMC81297.1 - 1e-101 340.3 1.1 3.5e-101 338.5 0.0 1.9 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EMC81297.1 - 3.4e-14 53.0 1.7 4.6e-11 42.9 0.0 3.5 4 0 0 4 4 4 2 Microtubule binding ADIP PF11559.8 EMC81297.1 - 0.00048 20.2 11.2 0.00048 20.2 11.2 2.0 2 0 0 2 2 1 1 Afadin- and alpha -actinin-Binding TMF_DNA_bd PF12329.8 EMC81297.1 - 0.0026 17.7 16.8 0.0026 17.7 16.8 2.0 2 0 0 2 2 2 1 TATA element modulatory factor 1 DNA binding SpecificRecomb PF10136.9 EMC81297.1 - 0.024 13.0 4.0 0.034 12.5 4.0 1.1 1 0 0 1 1 1 0 Site-specific recombinase HrpB7 PF09486.10 EMC81297.1 - 0.15 12.5 7.2 0.4 11.0 0.3 2.6 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) Bacillus_HBL PF05791.11 EMC81297.1 - 0.37 10.6 8.3 0.08 12.8 3.7 2.1 1 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Spc7 PF08317.11 EMC81297.1 - 0.65 8.8 17.5 1.1 8.0 17.5 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein FlxA PF14282.6 EMC81297.1 - 1.3 9.0 11.9 0.37 10.8 8.5 1.8 2 0 0 2 2 1 0 FlxA-like protein GBP_C PF02841.14 EMC81297.1 - 1.7 8.0 20.1 5 6.5 20.1 1.7 1 1 0 1 1 1 0 Guanylate-binding protein, C-terminal domain DUF3847 PF12958.7 EMC81297.1 - 2.1 8.5 14.5 5.8 7.1 5.2 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3847) V_ATPase_I PF01496.19 EMC81297.1 - 2.4 6.0 11.2 3.9 5.3 11.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Lzipper-MIP1 PF14389.6 EMC81297.1 - 3.3 8.1 12.9 1.2 9.5 3.8 2.6 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Syntaxin-6_N PF09177.11 EMC81297.1 - 3.8 8.1 12.3 2.9 8.5 1.5 3.2 2 1 1 3 3 3 0 Syntaxin 6, N-terminal DUF16 PF01519.16 EMC81297.1 - 4.5 7.8 13.0 3.6 8.1 10.0 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 SlyX PF04102.12 EMC81297.1 - 8.2 7.1 10.0 1.8 9.3 0.8 2.8 1 1 1 2 2 2 0 SlyX Sec8_exocyst PF04048.14 EMC81297.1 - 9.2 6.1 11.5 0.38 10.6 4.1 2.4 2 1 1 3 3 3 0 Sec8 exocyst complex component specific domain C5-epim_C PF06662.13 EMC81298.1 - 9.8e-75 250.2 0.0 1.6e-74 249.5 0.0 1.3 1 0 0 1 1 1 1 D-glucuronyl C5-epimerase C-terminus DUF4962 PF16332.5 EMC81298.1 - 0.035 12.6 0.2 0.088 11.3 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4962) EspG PF06872.11 EMC81298.1 - 0.053 12.1 0.0 0.23 10.0 0.0 1.8 2 0 0 2 2 2 0 EspG protein NAD_binding_6 PF08030.12 EMC81299.1 - 2.4e-29 102.5 0.0 4.5e-29 101.6 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EMC81299.1 - 1.5e-21 76.5 0.0 2.8e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 EMC81299.1 - 8.7e-19 67.9 3.8 8.7e-19 67.9 3.8 2.0 2 0 0 2 2 2 1 Ferric reductase like transmembrane component EF-hand_6 PF13405.6 EMC81299.1 - 1e-18 65.6 0.1 9e-06 25.2 0.1 4.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 EMC81299.1 - 2.3e-18 64.3 1.1 6.1e-06 25.4 0.0 5.4 5 0 0 5 5 5 2 EF hand EF-hand_5 PF13202.6 EMC81299.1 - 2.5e-14 52.0 5.2 3.7e-05 23.0 0.0 4.4 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 EMC81299.1 - 2.6e-11 43.8 0.4 0.00017 21.9 0.0 3.5 2 1 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 EMC81299.1 - 3.8e-06 26.6 0.1 0.18 11.7 0.0 3.7 2 2 0 2 2 2 2 EF-hand domain pair NAD_binding_1 PF00175.21 EMC81299.1 - 0.00097 19.8 0.1 0.065 13.9 0.1 2.7 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EMC81299.1 - 0.056 13.8 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain IBR PF01485.21 EMC81299.1 - 1.1 9.6 5.9 5.1 7.4 5.9 2.1 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain LRR_9 PF14580.6 EMC81301.1 - 3.2e-19 69.1 0.1 4.3e-19 68.7 0.1 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EMC81301.1 - 1.2e-12 47.8 12.2 1.6e-09 37.8 1.3 3.2 1 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMC81301.1 - 1.2e-08 34.5 17.0 1.6e-06 27.7 4.3 2.8 1 1 1 2 2 2 2 Leucine rich repeat LRR_6 PF13516.6 EMC81301.1 - 1e-07 31.4 8.9 0.00092 19.1 0.5 3.8 3 0 0 3 3 3 3 Leucine Rich repeat LRR_1 PF00560.33 EMC81301.1 - 0.00021 21.4 6.7 1.1 10.1 0.2 4.2 4 0 0 4 4 4 3 Leucine Rich Repeat LRR_2 PF07723.13 EMC81301.1 - 0.17 12.6 2.7 15 6.4 0.1 3.8 4 0 0 4 4 4 0 Leucine Rich Repeat WD40 PF00400.32 EMC81302.1 - 3.8e-14 52.8 1.4 0.0014 19.4 0.0 3.6 4 0 0 4 4 4 3 WD domain, G-beta repeat DUF1899 PF08953.11 EMC81302.1 - 1.5e-09 37.6 0.0 2.8e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) ANAPC4_WD40 PF12894.7 EMC81302.1 - 2.3e-07 31.0 0.0 0.066 13.5 0.0 3.2 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMC81302.1 - 0.026 13.5 0.0 1.3 7.9 0.0 2.1 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EMC81302.1 - 0.25 10.0 0.0 0.95 8.0 0.0 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Integrin_alpha2 PF08441.12 EMC81304.1 - 9.9e-37 126.9 0.0 1.5e-36 126.4 0.0 1.2 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 EMC81304.1 - 3.7e-09 36.5 2.7 4e-06 26.8 0.0 2.4 2 0 0 2 2 2 2 FG-GAP repeat VCBS PF13517.6 EMC81304.1 - 0.0008 20.0 0.1 0.016 15.8 0.1 2.5 1 1 1 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.6 EMC81304.1 - 0.07 13.4 0.0 0.21 11.8 0.0 1.8 2 0 0 2 2 2 0 FG-GAP repeat HisK_sensor PF18698.1 EMC81304.1 - 0.16 12.3 0.0 0.36 11.2 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase sensor domain Ank_2 PF12796.7 EMC81305.1 - 4.4e-45 152.2 11.5 2.9e-19 69.4 0.9 4.8 3 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC81305.1 - 8.3e-35 118.7 6.3 5e-12 46.1 0.1 7.1 3 2 4 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 EMC81305.1 - 1.2e-32 110.9 15.6 8.4e-06 26.0 0.1 8.0 8 0 0 8 8 8 7 Ankyrin repeat Ank_3 PF13606.6 EMC81305.1 - 7.9e-32 105.7 11.5 4.1e-05 23.6 0.0 8.7 7 1 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.6 EMC81305.1 - 2.1e-28 98.0 15.0 4.1e-06 27.0 0.1 7.7 3 2 4 7 7 7 6 Ankyrin repeats (many copies) CLN6 PF15156.6 EMC81306.1 - 1.1e-144 480.9 18.0 1.2e-144 480.8 18.0 1.0 1 0 0 1 1 1 1 Ceroid-lipofuscinosis neuronal protein 6 Zn_dep_PLPC PF00882.18 EMC81306.1 - 0.047 13.7 0.0 0.093 12.7 0.0 1.5 1 1 0 1 1 1 0 Zinc dependent phospholipase C CcmD PF04995.14 EMC81306.1 - 0.55 10.4 2.6 47 4.2 0.0 2.3 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) DUF4668 PF15701.5 EMC81306.1 - 0.69 9.7 6.2 1.5 8.6 1.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4668) Herpes_LMP1 PF05297.11 EMC81306.1 - 1.1 8.4 4.8 2.2 7.4 4.8 1.5 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Saf_2TM PF18303.1 EMC81306.1 - 1.2 8.7 5.1 0.94 9.1 2.6 1.9 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain EF-hand_6 PF13405.6 EMC81307.1 - 7.1e-06 25.6 0.0 1.6e-05 24.5 0.0 1.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 EMC81307.1 - 8.1e-06 26.2 0.0 1e-05 25.9 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EMC81307.1 - 2.2e-05 23.7 0.1 3e-05 23.3 0.1 1.2 1 0 0 1 1 1 1 EF hand EF-hand_9 PF14658.6 EMC81307.1 - 0.0038 17.5 0.0 0.0046 17.3 0.0 1.1 1 0 0 1 1 1 1 EF-hand domain GPHH PF16905.5 EMC81307.1 - 0.0048 16.6 0.0 0.0066 16.2 0.0 1.2 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated DUF2666 PF10869.8 EMC81307.1 - 0.077 13.2 0.0 0.081 13.1 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2666) Caleosin PF05042.13 EMC81307.1 - 0.096 12.6 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 Caleosin related protein PINIT PF14324.6 EMC81308.1 - 3.4e-31 108.6 0.1 9.4e-31 107.1 0.1 1.7 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 EMC81308.1 - 4.7e-21 74.3 5.4 9.3e-21 73.3 5.4 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EMC81308.1 - 0.00011 21.9 1.8 0.00029 20.6 1.8 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4 PF00097.25 EMC81308.1 - 1.2 9.1 5.3 4.6 7.2 5.3 2.1 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) MRNIP PF15749.5 EMC81308.1 - 1.8 9.3 8.2 38 5.1 8.2 2.3 1 1 0 1 1 1 0 MRN-interacting protein PHD PF00628.29 EMC81308.1 - 6.8 6.7 8.6 0.37 10.7 2.5 2.1 2 0 0 2 2 2 0 PHD-finger c-SKI_SMAD_bind PF08782.10 EMC81309.1 - 2e-33 114.5 1.8 2e-33 114.5 1.8 1.9 2 0 0 2 2 2 1 c-SKI Smad4 binding domain Ski_Sno PF02437.17 EMC81309.1 - 7.1e-26 90.1 0.2 1.5e-25 89.0 0.2 1.6 1 0 0 1 1 1 1 SKI/SNO/DAC family Jas PF16135.5 EMC81309.1 - 0.052 13.7 1.5 0.08 13.1 0.4 1.8 2 0 0 2 2 2 0 TPL-binding domain in jasmonate signalling Pkinase PF00069.25 EMC81310.1 - 4e-63 213.3 0.0 4.9e-63 213.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81310.1 - 5.2e-39 134.1 0.0 6.7e-39 133.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC81310.1 - 3.9e-05 22.6 0.0 4.8e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EMC81310.1 - 0.00056 19.3 0.0 0.0013 18.1 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EMC81310.1 - 0.00059 18.9 0.0 0.035 13.0 0.0 2.1 1 1 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 EMC81310.1 - 0.085 11.9 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Adaptin_binding PF10199.9 EMC81312.1 - 1.2e-18 67.9 2.1 2.2e-18 67.0 2.1 1.5 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 Ras PF00071.22 EMC81312.1 - 0.0087 15.7 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 Ras family Hrs_helical PF12210.8 EMC81312.1 - 0.094 13.3 0.7 0.18 12.4 0.7 1.4 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate MH2 PF03166.14 EMC81313.1 - 3e-56 190.6 0.0 3.6e-56 190.3 0.0 1.1 1 0 0 1 1 1 1 MH2 domain Glyco_hydro_1 PF00232.18 EMC81314.1 - 5.8e-162 539.2 7.2 6.6e-162 539.0 7.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Glyco_hydro_10 PF00331.20 EMC81314.1 - 0.015 14.5 0.9 0.45 9.6 0.0 2.4 2 0 0 2 2 2 0 Glycosyl hydrolase family 10 DUF3377 PF11857.8 EMC81314.1 - 0.16 11.9 0.5 0.31 11.0 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Zwilch PF09817.9 EMC81315.1 - 5.8e-142 474.1 1.9 7.1e-142 473.8 1.9 1.1 1 0 0 1 1 1 1 RZZ complex, subunit zwilch Ribosomal_L4 PF00573.22 EMC81316.1 - 4.7e-40 137.3 0.1 4.7e-40 137.3 0.1 1.6 2 0 0 2 2 2 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 EMC81316.1 - 5.7e-30 103.2 7.0 1.9e-29 101.5 7.0 1.9 1 0 0 1 1 1 1 60S ribosomal protein L4 C-terminal domain SNAPc19 PF15497.6 EMC81317.1 - 2.9e-13 50.1 8.6 3.1e-13 50.0 8.6 1.0 1 0 0 1 1 1 1 snRNA-activating protein complex subunit 19, SNAPc subunit 19 Pkinase PF00069.25 EMC81318.1 - 4.5e-62 209.8 0.0 5.9e-62 209.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81318.1 - 1.9e-34 119.2 0.0 7.5e-33 113.9 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC81318.1 - 6.4e-06 25.2 0.0 9.6e-06 24.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EMC81318.1 - 0.0053 15.8 0.0 0.01 14.8 0.0 1.3 1 1 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 EMC81318.1 - 0.016 14.3 0.0 0.025 13.6 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kinase-like PF14531.6 EMC81318.1 - 0.027 13.8 0.0 0.065 12.5 0.0 1.6 1 0 0 1 1 1 0 Kinase-like Swi3 PF07962.12 EMC81319.1 - 1.7e-34 117.6 0.2 2.6e-34 117.0 0.2 1.3 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 RNB PF00773.19 EMC81320.1 - 1.8e-86 290.5 0.1 3.1e-86 289.7 0.1 1.4 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 EMC81320.1 - 2e-21 75.8 0.0 5.1e-21 74.5 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 EMC81320.1 - 4e-08 33.3 0.1 9.3e-05 22.5 0.0 3.1 2 1 0 2 2 2 2 Cold shock domain Rrp44_CSD1 PF17216.3 EMC81320.1 - 6.7e-07 29.1 0.0 1.6e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 EMC81320.1 - 3e-06 27.1 0.0 9.4e-06 25.5 0.0 1.9 1 0 0 1 1 1 1 S1 domain OB_RNB PF08206.11 EMC81320.1 - 0.11 12.2 0.0 0.43 10.3 0.0 1.9 2 0 0 2 2 2 0 Ribonuclease B OB domain zf-H2C2_2 PF13465.6 EMC81321.1 - 2.5e-288 919.2 266.7 2.4e-08 34.0 0.4 39.1 39 0 0 39 39 39 38 Zinc-finger double domain zf-C2H2 PF00096.26 EMC81321.1 - 3.3e-189 603.6 351.1 2.4e-06 27.7 1.9 39.0 39 0 0 39 39 39 38 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC81321.1 - 9.4e-112 355.9 319.1 0.0019 18.9 1.3 38.2 38 0 0 38 38 38 38 C2H2-type zinc finger zf-LYAR PF08790.11 EMC81321.1 - 2.6e-38 129.6 222.0 0.018 15.0 0.2 37.8 38 0 0 38 38 38 25 LYAR-type C2HC zinc finger zf-C2H2_8 PF15909.5 EMC81321.1 - 8.6e-37 125.4 166.9 0.0027 18.0 3.4 19.8 1 1 24 26 26 26 22 C2H2-type zinc ribbon Zn-ribbon_8 PF09723.10 EMC81321.1 - 8.2e-33 112.2 169.9 0.0047 17.0 2.2 23.6 12 5 16 29 29 29 24 Zinc ribbon domain zf-trcl PF13451.6 EMC81321.1 - 1.3e-22 79.4 192.8 0.66 9.9 0.6 36.6 35 3 0 35 35 35 14 Probable zinc-ribbon domain zf-C2H2_6 PF13912.6 EMC81321.1 - 3.8e-22 77.8 276.9 0.011 15.7 0.3 37.2 38 0 0 38 38 38 21 C2H2-type zinc finger zf_UBZ PF18439.1 EMC81321.1 - 1.8e-20 72.2 177.2 1.5 8.5 0.3 37.5 38 0 0 38 38 38 8 Ubiquitin-Binding Zinc Finger KRAB PF01352.27 EMC81321.1 - 1.9e-20 72.2 0.2 3.6e-20 71.3 0.2 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.8 EMC81321.1 - 5.2e-19 68.0 148.8 0.099 13.0 0.4 32.5 34 0 0 34 34 33 6 Zinc-finger double-stranded RNA-binding ADK_lid PF05191.14 EMC81321.1 - 9.9e-19 67.0 132.1 0.057 13.4 0.9 23.4 16 4 7 23 23 23 11 Adenylate kinase, active site lid HypA PF01155.19 EMC81321.1 - 3.6e-13 49.5 131.7 0.98 9.5 1.0 20.5 1 1 20 21 21 21 10 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_C2H2_ZHX PF18387.1 EMC81321.1 - 1.6e-12 46.8 199.4 0.35 10.5 0.4 32.3 2 2 33 36 36 36 19 Zinc-fingers and homeoboxes C2H2 finger domain CpXC PF14353.6 EMC81321.1 - 1.4e-11 44.4 159.7 5.7 7.0 0.2 34.3 4 4 24 33 33 33 1 CpXC protein LIM PF00412.22 EMC81321.1 - 4e-10 39.8 212.2 3 8.1 3.0 30.8 1 1 37 38 38 38 7 LIM domain DUF3268 PF11672.8 EMC81321.1 - 2.7e-09 37.4 105.1 1.9 8.8 0.1 18.8 4 3 7 22 22 22 4 zinc-finger-containing domain zf-AN1 PF01428.16 EMC81321.1 - 1.1e-07 31.9 237.3 0.42 10.8 1.1 37.8 26 7 12 38 38 38 2 AN1-like Zinc finger BHD_1 PF10403.9 EMC81321.1 - 1.4e-07 31.2 12.5 17 5.3 0.0 12.2 14 1 1 15 15 12 0 Rad4 beta-hairpin domain 1 zinc_ribbon_15 PF17032.5 EMC81321.1 - 1.5e-07 32.1 140.5 2.6 8.9 0.9 19.4 1 1 20 24 24 24 3 zinc-ribbon family DUF4712 PF15830.5 EMC81321.1 - 0.00029 20.6 4.0 6.3 6.4 0.0 6.1 4 2 3 7 7 7 1 Domain of unknown function (DUF4712) zf-C2HE PF16278.5 EMC81321.1 - 0.0021 18.5 247.8 2.3 8.7 2.6 37.3 5 5 27 32 32 32 2 C2HE / C2H2 / C2HC zinc-binding finger FYDLN_acid PF09538.10 EMC81321.1 - 0.0089 16.7 102.0 30 5.4 0.5 30.2 2 2 22 29 29 29 0 Protein of unknown function (FYDLN_acid) YhfH PF14149.6 EMC81321.1 - 0.038 14.0 157.4 8.1 6.5 0.1 32.9 37 0 0 37 37 34 0 YhfH-like protein Dermcidin PF15291.6 EMC81321.1 - 0.17 12.4 0.0 60 4.3 0.0 5.0 6 1 1 7 7 3 0 Dermcidin, antibiotic peptide RNase_T PF00929.24 EMC81322.1 - 1e-29 104.2 0.0 2.9e-29 102.7 0.0 1.6 2 0 0 2 2 2 1 Exonuclease SAP PF02037.27 EMC81322.1 - 1.9e-07 30.7 0.8 3.5e-07 29.8 0.8 1.5 1 0 0 1 1 1 1 SAP domain DSPc PF00782.20 EMC81323.1 - 2.1e-45 153.8 0.1 2.6e-45 153.5 0.1 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC81323.1 - 3.6e-06 26.7 0.0 4.7e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 EMC81323.1 - 0.055 13.1 0.2 0.084 12.5 0.2 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 EMC81323.1 - 0.12 12.5 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 Inositol hexakisphosphate Kazal_1 PF00050.21 EMC81324.1 - 1.2e-14 54.0 4.8 1.3e-14 53.9 4.8 1.0 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 EMC81324.1 - 9.2e-10 38.5 2.1 1.1e-09 38.2 2.1 1.2 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Rtf2 PF04641.12 EMC81325.1 - 0.0026 17.2 0.0 0.0035 16.7 0.0 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger Homeodomain PF00046.29 EMC81326.1 - 1.3e-09 37.7 0.1 1.5e-09 37.5 0.1 1.1 1 0 0 1 1 1 1 Homeodomain Colicin_Pyocin PF01320.18 EMC81326.1 - 0.017 15.3 0.0 0.023 14.8 0.0 1.2 1 0 0 1 1 1 0 Colicin immunity protein / pyocin immunity protein GlgS PF08971.11 EMC81326.1 - 0.13 12.3 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Glycogen synthesis protein Homez PF11569.8 EMC81326.1 - 0.13 11.7 0.1 0.21 11.1 0.1 1.3 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Arf PF00025.21 EMC81327.1 - 7.1e-37 126.5 0.0 8e-37 126.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EMC81327.1 - 4.4e-10 39.3 0.0 5.5e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EMC81327.1 - 5.6e-09 36.3 0.0 1e-08 35.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMC81327.1 - 7.9e-08 32.1 0.0 9.3e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EMC81327.1 - 9.6e-06 25.1 0.0 1.3e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 EMC81327.1 - 0.0075 16.5 0.2 0.044 14.1 0.2 2.1 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EMC81327.1 - 0.008 16.6 0.2 0.08 13.4 0.2 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EMC81327.1 - 0.011 16.1 0.0 0.018 15.5 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 EMC81327.1 - 0.015 14.5 0.0 0.2 10.8 0.0 2.2 1 1 1 2 2 2 0 G-protein alpha subunit MMR_HSR1 PF01926.23 EMC81327.1 - 0.02 15.0 0.0 0.032 14.3 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase NOG1 PF06858.14 EMC81327.1 - 0.061 13.1 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) SRP72 PF08492.12 EMC81328.1 - 2.6e-22 79.0 10.3 2.6e-22 79.0 10.3 3.0 2 0 0 2 2 2 1 SRP72 RNA-binding domain SRP_TPR_like PF17004.5 EMC81328.1 - 4e-21 75.2 2.1 4e-21 75.2 2.1 3.2 2 1 0 3 3 3 1 Putative TPR-like repeat TPR_19 PF14559.6 EMC81328.1 - 5.1e-15 55.7 12.9 0.0068 16.9 0.1 7.0 4 3 2 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 EMC81328.1 - 6.7e-15 53.9 14.7 0.0063 16.5 0.0 8.0 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 EMC81328.1 - 2.5e-12 46.5 6.3 0.38 11.7 0.0 7.8 5 3 1 7 7 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 EMC81328.1 - 2.7e-10 39.6 11.0 0.026 14.3 0.0 7.1 7 0 0 7 7 7 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC81328.1 - 8.4e-10 38.7 20.2 2.1e-05 24.7 1.4 6.6 4 3 2 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EMC81328.1 - 8.9e-08 32.3 20.4 8.8e-05 22.7 0.3 6.7 7 2 1 8 8 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMC81328.1 - 2e-07 30.7 14.3 0.14 12.4 0.9 7.1 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 EMC81328.1 - 2.5e-07 30.9 18.1 0.51 11.1 0.1 8.3 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_11 PF13414.6 EMC81328.1 - 1.8e-06 27.5 8.1 0.17 11.6 0.0 5.9 6 0 0 6 6 6 2 TPR repeat BTAD PF03704.17 EMC81328.1 - 5.5e-06 26.9 8.2 0.028 14.9 0.2 4.6 4 2 0 4 4 4 2 Bacterial transcriptional activator domain TPR_16 PF13432.6 EMC81328.1 - 0.00028 21.5 3.3 13 6.6 0.3 6.4 8 0 0 8 8 8 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 EMC81328.1 - 0.00052 19.6 5.8 0.008 15.8 0.5 4.6 4 2 1 6 6 5 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_9 PF13371.6 EMC81328.1 - 0.00053 20.1 3.0 1.7 8.8 0.0 5.3 5 1 0 5 5 5 1 Tetratricopeptide repeat PPR PF01535.20 EMC81328.1 - 0.00093 19.3 0.1 25 5.4 0.0 5.3 6 0 0 6 6 5 0 PPR repeat TPR_7 PF13176.6 EMC81328.1 - 0.0027 17.6 6.4 32 4.9 0.0 5.9 6 0 0 6 6 5 0 Tetratricopeptide repeat ATP13 PF12921.7 EMC81328.1 - 0.066 13.1 0.1 2.9 7.8 0.0 3.2 2 1 1 3 3 3 0 Mitochondrial ATPase expression TPR_17 PF13431.6 EMC81328.1 - 0.075 13.4 0.3 1.6e+02 3.1 0.0 5.0 5 0 0 5 5 3 0 Tetratricopeptide repeat PPR_2 PF13041.6 EMC81328.1 - 0.084 13.1 0.2 87 3.4 0.0 4.3 5 0 0 5 5 4 0 PPR repeat family PMEI PF04043.15 EMC81328.1 - 0.15 12.4 12.2 0.11 12.8 0.9 3.9 2 2 2 4 4 4 0 Plant invertase/pectin methylesterase inhibitor HemY_N PF07219.13 EMC81328.1 - 0.21 11.8 4.7 38 4.5 0.1 4.5 4 0 0 4 4 4 0 HemY protein N-terminus DUF4919 PF16266.5 EMC81328.1 - 0.22 11.4 3.1 0.94 9.4 0.0 3.1 4 0 0 4 4 3 0 Domain of unknown function (DUF4919) ASL_C PF08328.11 EMC81328.1 - 0.62 10.2 4.4 19 5.4 0.1 4.0 3 2 1 4 4 4 0 Adenylosuccinate lyase C-terminal TPR_10 PF13374.6 EMC81328.1 - 0.75 9.8 5.3 36 4.4 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat CCDC-167 PF15188.6 EMC81328.1 - 3.3 8.1 8.2 0.12 12.7 0.7 2.6 4 0 0 4 4 2 0 Coiled-coil domain-containing protein 167 Vps55 PF04133.14 EMC81329.1 - 6.6e-40 135.7 6.4 7.4e-40 135.6 6.4 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 YwiC PF14256.6 EMC81329.1 - 0.065 13.6 5.9 0.15 12.4 5.9 1.6 1 1 0 1 1 1 0 YwiC-like protein DUF4231 PF14015.6 EMC81329.1 - 0.066 13.7 0.4 0.11 13.0 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) TMEM238 PF15125.6 EMC81329.1 - 7.2 6.9 10.8 0.92 9.8 3.6 2.2 2 0 0 2 2 2 0 TMEM238 protein family SARAF PF06682.12 EMC81330.1 - 5.5e-66 223.5 0.1 6.1e-66 223.3 0.1 1.0 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis UPF0114 PF03350.16 EMC81330.1 - 0.16 12.2 0.0 0.24 11.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein family, UPF0114 zf-H2C2_2 PF13465.6 EMC81331.1 - 6e-30 102.3 67.7 3.4e-08 33.5 1.3 11.3 11 1 0 11 11 11 7 Zinc-finger double domain zf-H2C2_5 PF13909.6 EMC81331.1 - 8.1e-27 92.6 70.0 1.3e-06 28.0 4.3 9.4 10 0 0 10 10 10 6 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 EMC81331.1 - 1.2e-17 63.3 79.8 0.00037 20.8 4.0 9.5 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC81331.1 - 4.2e-12 45.8 72.8 0.049 14.5 0.8 9.7 9 0 0 9 9 9 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC81331.1 - 0.013 15.8 0.9 0.013 15.8 0.9 7.5 7 0 0 7 7 7 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EMC81331.1 - 1.1 9.7 42.6 0.89 9.9 8.2 6.0 2 1 3 6 6 6 0 C2H2 type zinc-finger (2 copies) MMR_HSR1 PF01926.23 EMC81332.1 - 9.2e-10 38.6 0.0 6.5e-09 35.9 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EMC81332.1 - 0.0015 18.6 0.1 0.0054 16.8 0.1 1.9 1 1 0 1 1 1 1 Dynamin family AAA_29 PF13555.6 EMC81332.1 - 0.017 14.9 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain FeoB_N PF02421.18 EMC81332.1 - 0.024 14.1 0.1 0.06 12.9 0.1 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B FtsK_SpoIIIE PF01580.18 EMC81332.1 - 0.042 13.2 0.0 0.089 12.1 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AIG1 PF04548.16 EMC81332.1 - 0.06 12.7 0.0 0.16 11.3 0.0 1.7 2 0 0 2 2 2 0 AIG1 family ABC_tran PF00005.27 EMC81332.1 - 0.073 13.6 0.1 0.43 11.1 0.0 2.0 1 1 0 2 2 2 0 ABC transporter RsgA_GTPase PF03193.16 EMC81332.1 - 0.13 12.2 0.0 0.42 10.5 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase SRPRB PF09439.10 EMC81332.1 - 0.19 11.1 0.0 0.33 10.4 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Varsurf_PPLC PF03490.13 EMC81332.1 - 0.2 11.6 0.0 7.8 6.5 0.0 2.3 2 0 0 2 2 2 0 Variant-surface-glycoprotein phospholipase C RNA_pol_Rpb2_6 PF00562.28 EMC81333.1 - 2.5e-128 428.5 0.2 3.6e-128 427.9 0.2 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EMC81333.1 - 3e-68 229.3 0.1 6.6e-68 228.2 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EMC81333.1 - 3e-56 190.1 0.0 8.9e-56 188.5 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EMC81333.1 - 4e-34 116.9 1.5 7.6e-34 116.0 0.2 2.2 3 0 0 3 3 3 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 EMC81333.1 - 3e-24 85.1 0.8 7.6e-24 83.8 0.8 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 EMC81333.1 - 6.4e-24 83.9 0.0 1.6e-23 82.7 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EMC81333.1 - 7.8e-19 68.0 0.5 1.9e-18 66.7 0.5 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Amidoligase_2 PF12224.8 EMC81333.1 - 0.022 14.5 0.0 0.037 13.7 0.0 1.3 1 0 0 1 1 1 0 Putative amidoligase enzyme I-set PF07679.16 EMC81334.1 - 9.1e-12 44.9 0.1 7.2e-11 42.0 0.1 2.4 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC81334.1 - 1.6e-10 41.4 0.1 3.5e-10 40.4 0.1 1.6 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC81334.1 - 3.3e-06 27.2 0.0 1.1e-05 25.5 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC81334.1 - 0.00013 22.3 0.0 0.00078 19.7 0.0 1.9 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC81334.1 - 0.00014 22.0 0.0 0.00065 19.9 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin V-set domain RCC1 PF00415.18 EMC81335.1 - 4.8e-47 158.4 11.6 1.2e-14 54.7 0.3 4.2 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EMC81335.1 - 4.1e-21 74.3 15.5 1.1e-07 31.5 1.1 4.5 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EMC81336.1 - 5.2e-85 279.9 31.2 4.6e-14 52.8 0.1 7.6 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat HECT PF00632.25 EMC81336.1 - 3e-81 273.3 0.6 4.3e-81 272.8 0.6 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) RCC1_2 PF13540.6 EMC81336.1 - 1.8e-48 161.4 42.6 5.6e-10 38.8 0.1 7.6 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RhoGAP PF00620.27 EMC81337.1 - 3e-22 79.1 0.0 3.9e-22 78.7 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain DUF4314 PF14192.6 EMC81337.1 - 0.015 15.2 0.2 0.027 14.4 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4314) LAGLIDADG_2 PF03161.13 EMC81337.1 - 0.093 12.7 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 LAGLIDADG DNA endonuclease family EAP30 PF04157.16 EMC81337.1 - 0.15 11.3 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 EAP30/Vps36 family GRIN_C PF15235.6 EMC81338.1 - 3.4e-50 169.7 3.7 3.4e-50 169.7 3.7 2.5 2 0 0 2 2 2 1 G protein-regulated inducer of neurite outgrowth C-terminus CENP-C_C PF11699.8 EMC81339.1 - 4.4e-28 97.3 0.3 1.1e-27 96.1 0.3 1.7 1 0 0 1 1 1 1 Mif2/CENP-C like Cupin_2 PF07883.11 EMC81339.1 - 0.00011 21.9 0.0 0.00025 20.7 0.0 1.5 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 EMC81339.1 - 0.026 14.2 0.0 0.073 12.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF861) DUF2554 PF10829.8 EMC81339.1 - 0.12 12.8 0.5 1.8 9.0 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2554) CLASP_N PF12348.8 EMC81340.1 - 1.6e-10 41.0 0.2 1.7e-10 40.9 0.2 1.0 1 0 0 1 1 1 1 CLASP N terminal HEAT_EZ PF13513.6 EMC81340.1 - 0.0012 19.2 0.7 0.39 11.3 0.0 3.0 3 1 0 3 3 3 1 HEAT-like repeat RTP1_C1 PF10363.9 EMC81340.1 - 0.03 14.5 0.0 0.04 14.1 0.0 1.2 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 EMC81340.1 - 0.062 13.7 0.2 0.25 11.7 0.3 1.7 1 1 1 2 2 2 0 HEAT repeats DNA_alkylation PF08713.11 EMC81340.1 - 0.11 12.2 0.0 0.28 10.9 0.0 1.6 1 1 1 2 2 2 0 DNA alkylation repair enzyme Pkinase_Tyr PF07714.17 EMC81341.1 - 2.2e-98 328.7 0.0 3.1e-98 328.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.19 EMC81341.1 - 7.2e-71 237.9 0.0 1.2e-70 237.1 0.0 1.4 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.25 EMC81341.1 - 3.3e-49 167.6 0.0 5e-49 167.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 EMC81341.1 - 6.1e-31 106.6 0.6 6.6e-14 52.0 0.0 3.0 4 0 0 4 4 2 2 Fibronectin type III domain EphA2_TM PF14575.6 EMC81341.1 - 5.5e-21 75.2 0.0 1.3e-20 74.0 0.0 1.7 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_1 PF00536.30 EMC81341.1 - 1e-08 35.5 0.0 2e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC81341.1 - 6.9e-08 32.5 0.0 1.3e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pur_ac_phosph_N PF16656.5 EMC81341.1 - 4.6e-06 27.1 0.1 0.00063 20.3 0.0 2.6 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Ephrin_rec_like PF07699.13 EMC81341.1 - 5.5e-05 22.8 7.6 5.5e-05 22.8 7.6 2.3 2 0 0 2 2 2 1 Putative ephrin-receptor like HNH_5 PF14279.6 EMC81341.1 - 0.0021 17.9 0.3 0.0081 16.0 0.3 2.1 1 0 0 1 1 1 1 HNH endonuclease fn3_2 PF16893.5 EMC81341.1 - 0.0057 16.8 0.2 4.6 7.5 0.1 2.9 3 0 0 3 3 2 1 Fibronectin type III domain Haspin_kinase PF12330.8 EMC81341.1 - 0.013 14.5 0.0 0.021 13.8 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Interfer-bind PF09294.10 EMC81341.1 - 0.022 15.1 0.0 2.5 8.5 0.0 3.4 3 0 0 3 3 3 0 Interferon-alpha/beta receptor, fibronectin type III Kdo PF06293.14 EMC81341.1 - 0.03 13.7 0.0 0.05 13.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4998 PF16389.5 EMC81341.1 - 0.057 13.0 0.6 0.18 11.4 0.6 1.8 1 1 0 1 1 1 0 Domain of unknown function Pkinase_fungal PF17667.1 EMC81341.1 - 0.12 11.1 0.0 0.21 10.3 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase SusE PF14292.6 EMC81341.1 - 0.14 12.4 0.0 7.7 6.8 0.1 2.5 2 0 0 2 2 2 0 SusE outer membrane protein zinc_ribbon_10 PF10058.9 EMC81341.1 - 7.8 6.3 7.2 1.5 8.6 1.0 2.8 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Asp PF00026.23 EMC81343.1 - 5.9e-70 236.2 0.3 6.8e-70 236.0 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EMC81343.1 - 1.4e-17 64.5 1.3 6.3e-15 55.8 1.3 2.2 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.12 EMC81343.1 - 9.9e-12 44.5 1.8 1.5e-11 43.9 1.8 1.3 1 0 0 1 1 1 1 A1 Propeptide Asp_protease_2 PF13650.6 EMC81343.1 - 0.032 14.9 0.0 0.08 13.6 0.0 1.7 1 1 0 1 1 1 0 Aspartyl protease SRCR PF00530.18 EMC81345.1 - 1e-42 144.7 17.3 3.8e-26 91.5 6.6 2.1 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 EMC81345.1 - 4.3e-06 27.2 9.6 0.0074 16.8 0.1 2.6 3 0 0 3 3 3 2 Scavenger receptor cysteine-rich domain BRI3BP PF14965.6 EMC81346.1 - 3.6e-51 173.2 3.9 4e-51 173.1 3.9 1.0 1 0 0 1 1 1 1 Negative regulator of p53/TP53 Prp19 PF08606.11 EMC81347.1 - 3.3e-33 113.5 2.5 3.3e-33 113.5 2.5 1.8 2 0 0 2 2 1 1 Prp19/Pso4-like WD40 PF00400.32 EMC81347.1 - 1.2e-31 108.2 12.9 4e-08 33.8 0.0 7.2 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC81347.1 - 1.8e-14 53.8 0.0 0.0026 18.0 0.0 5.1 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain U-box PF04564.15 EMC81347.1 - 2e-06 27.9 0.0 4.5e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 U-box domain Ge1_WD40 PF16529.5 EMC81347.1 - 9.7e-05 21.5 0.6 1.4 7.8 0.0 3.3 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EMC81347.1 - 0.00037 19.3 0.7 0.026 13.2 0.1 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 EMC81347.1 - 0.00047 18.8 0.0 0.6 8.6 0.0 2.4 2 0 0 2 2 2 2 Cytochrome D1 heme domain eIF2A PF08662.11 EMC81347.1 - 0.00088 19.2 0.0 1.1 9.1 0.0 2.7 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A DUF1830 PF08865.11 EMC81347.1 - 0.052 13.6 0.0 0.16 12.0 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1830) zf-Nse PF11789.8 EMC81347.1 - 0.067 13.0 0.1 0.18 11.6 0.0 1.7 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit Nucleoporin_N PF08801.11 EMC81347.1 - 0.07 11.9 0.1 1.4 7.6 0.0 2.2 1 1 1 2 2 2 0 Nup133 N terminal like GP3 PF03076.14 EMC81347.1 - 0.1 12.6 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Equine arteritis virus GP3 Cep57_MT_bd PF06657.13 EMC81347.1 - 0.19 12.2 0.5 0.41 11.1 0.1 1.9 2 0 0 2 2 1 0 Centrosome microtubule-binding domain of Cep57 BAAT_C PF08840.11 EMC81348.1 - 8.3e-52 176.2 0.0 9.2e-52 176.0 0.0 1.0 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 EMC81348.1 - 5.3e-07 29.4 0.0 1.2e-05 25.0 0.0 2.0 1 1 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.13 EMC81348.1 - 0.00035 20.3 0.0 0.0011 18.7 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Bile_Hydr_Trans PF04775.14 EMC81349.1 - 3e-40 137.2 0.0 3.4e-40 137.0 0.0 1.0 1 0 0 1 1 1 1 Acyl-CoA thioester hydrolase/BAAT N-terminal region CD20 PF04103.15 EMC81350.1 - 1.9e-21 76.8 17.3 6.2e-19 68.6 17.3 2.0 1 1 0 1 1 1 1 CD20-like family DUF3413 PF11893.8 EMC81350.1 - 0.084 12.0 5.3 0.18 10.9 5.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3413) Zona_pellucida PF00100.23 EMC81351.1 - 5.2e-12 46.1 0.0 6.2e-12 45.9 0.0 1.0 1 0 0 1 1 1 1 Zona pellucida-like domain Cobalamin_bind PF01122.19 EMC81352.1 - 1e-21 77.2 0.0 1.4e-21 76.7 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic cobalamin-binding protein DUF4430 PF14478.6 EMC81352.1 - 2.3e-13 50.5 0.0 3.2e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4430) Ribosomal_L16 PF00252.18 EMC81353.1 - 2.9e-18 66.1 0.1 4.3e-18 65.6 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e CybS PF05328.12 EMC81353.1 - 0.21 11.3 0.0 0.28 10.8 0.0 1.2 1 0 0 1 1 1 0 CybS, succinate dehydrogenase cytochrome B small subunit Syntaxin PF00804.25 EMC81354.1 - 4.7e-61 206.0 15.3 9.1e-61 205.0 15.3 1.5 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.19 EMC81354.1 - 3e-12 46.3 5.8 8e-12 45.0 0.2 3.0 3 0 0 3 3 3 1 SNARE domain Syntaxin_2 PF14523.6 EMC81354.1 - 2.9e-10 40.4 7.7 2.9e-10 40.4 7.7 2.3 2 1 0 2 2 2 1 Syntaxin-like protein GyrB_insert PF18053.1 EMC81354.1 - 0.0077 16.1 1.1 0.0077 16.1 1.1 2.0 2 0 0 2 2 2 1 DNA gyrase B subunit insert domain DUF3040 PF11239.8 EMC81354.1 - 0.014 15.6 1.4 0.16 12.3 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Phage_TTP_13 PF16463.5 EMC81354.1 - 0.02 14.4 0.0 0.04 13.4 0.0 1.4 1 0 0 1 1 1 0 Phage tail tube protein family Branch PF02485.21 EMC81354.1 - 0.029 13.9 0.1 0.045 13.3 0.1 1.4 1 0 0 1 1 1 0 Core-2/I-Branching enzyme Baculo_PEP_C PF04513.12 EMC81354.1 - 0.075 13.1 2.7 0.69 10.0 0.6 2.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus WXG100 PF06013.12 EMC81354.1 - 0.14 12.4 6.4 6.9 7.0 0.1 3.5 4 0 0 4 4 4 0 Proteins of 100 residues with WXG Prominin PF05478.11 EMC81354.1 - 0.18 9.7 12.3 0.93 7.4 0.1 2.4 2 1 0 2 2 2 0 Prominin Syntaxin-6_N PF09177.11 EMC81354.1 - 0.26 11.9 12.7 0.045 14.3 5.0 3.1 1 1 1 3 3 3 0 Syntaxin 6, N-terminal MCPsignal PF00015.21 EMC81354.1 - 0.33 10.8 10.7 4.1 7.2 0.2 3.0 1 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF2935 PF11155.8 EMC81354.1 - 0.57 10.5 4.1 0.67 10.3 1.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) DASH_Duo1 PF08651.10 EMC81354.1 - 0.7 9.7 6.6 0.93 9.3 0.1 3.1 3 1 0 3 3 3 0 DASH complex subunit Duo1 RP-C_C PF11800.8 EMC81354.1 - 1.4 9.0 11.9 0.82 9.7 5.4 2.6 2 1 1 3 3 3 0 Replication protein C C-terminal region Folliculin PF11704.8 EMC81354.1 - 1.6 8.6 5.7 4.2 7.2 5.7 1.9 1 1 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Fib_alpha PF08702.10 EMC81354.1 - 2.6 8.2 14.9 1.5 9.0 6.8 2.7 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.11 EMC81354.1 - 4.1 7.9 13.9 0.71 10.3 0.6 4.1 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) PAT1 PF09770.9 EMC81355.1 - 2.7e-13 49.2 12.0 3.6e-11 42.1 0.0 4.0 4 0 0 4 4 4 3 Topoisomerase II-associated protein PAT1 EF-hand_1 PF00036.32 EMC81356.1 - 5.3e-29 97.6 8.8 1.4e-08 33.7 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EMC81356.1 - 3.2e-24 85.1 3.5 5e-13 49.3 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EMC81356.1 - 3.8e-23 81.1 8.8 2.9e-11 43.0 0.5 3.7 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EMC81356.1 - 1.1e-22 78.0 3.3 4.1e-08 32.5 0.1 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 EMC81356.1 - 3.9e-19 67.2 11.1 8.7e-06 25.0 0.0 4.8 4 1 1 5 5 5 3 EF hand EF-hand_4 PF12763.7 EMC81356.1 - 2.4e-05 24.2 3.0 0.0021 18.0 0.1 3.0 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EMC81356.1 - 5.8e-05 23.3 0.2 0.019 15.3 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain Dockerin_1 PF00404.18 EMC81356.1 - 8.6e-05 22.7 1.5 0.018 15.2 0.9 3.0 2 2 1 3 3 3 2 Dockerin type I domain SPARC_Ca_bdg PF10591.9 EMC81356.1 - 0.00013 22.3 0.1 0.014 15.7 0.0 2.3 1 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.13 EMC81356.1 - 0.00014 21.9 0.3 0.077 13.0 0.0 2.7 2 1 0 2 2 2 2 Tellurite resistance protein TerB DIMCO_N PF16844.5 EMC81356.1 - 0.00038 20.7 0.1 0.00097 19.4 0.1 1.7 1 1 0 1 1 1 1 Dinitrogenase iron-molybdenum cofactor, N-terminal DUF3349 PF11829.8 EMC81356.1 - 0.0011 19.7 0.0 1.2 9.9 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3349) EF-hand_11 PF08976.11 EMC81356.1 - 0.014 16.3 0.0 3.3 8.6 0.0 2.1 1 1 1 2 2 2 0 EF-hand domain Caleosin PF05042.13 EMC81356.1 - 0.08 12.9 0.2 1.2 9.0 0.0 2.5 2 1 1 3 3 3 0 Caleosin related protein PTPRCAP PF15713.5 EMC81357.1 - 7.2e-18 65.3 10.3 8.6e-18 65.0 10.3 1.1 1 0 0 1 1 1 1 Protein tyrosine phosphatase receptor type C-associated RR_TM4-6 PF06459.12 EMC81357.1 - 0.55 10.0 5.0 0.68 9.7 5.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NOA36 PF06524.12 EMC81357.1 - 1.4 8.2 6.7 1.7 7.9 6.7 1.1 1 0 0 1 1 1 0 NOA36 protein Paf1 PF03985.13 EMC81357.1 - 3.5 6.5 13.1 4.2 6.3 13.1 1.0 1 0 0 1 1 1 0 Paf1 Metallophos PF00149.28 EMC81358.1 - 1.6e-40 139.8 0.1 2.1e-40 139.4 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EMC81358.1 - 9.8e-18 64.3 0.6 2.4e-17 63.1 0.3 1.8 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain PRF PF06875.11 EMC81359.1 - 2e-07 30.6 0.0 2.5e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Plethodontid receptivity factor PRF CNTF PF01110.17 EMC81359.1 - 2.7e-05 23.6 0.0 4.9e-05 22.8 0.0 1.5 1 1 0 1 1 1 1 Ciliary neurotrophic factor IL11 PF07400.11 EMC81359.1 - 0.11 12.1 0.0 0.76 9.4 0.0 2.0 2 0 0 2 2 2 0 Interleukin 11 Gly_acyl_tr_N PF06021.11 EMC81360.1 - 3.5e-34 118.7 0.0 1.4e-22 80.8 0.0 2.1 2 0 0 2 2 2 2 Aralkyl acyl-CoA:amino acid N-acyltransferase Gly_acyl_tr_C PF08444.10 EMC81360.1 - 2e-05 24.7 0.0 3.3e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region Autoind_bind PF03472.15 EMC81360.1 - 0.03 13.8 0.1 0.056 12.9 0.1 1.3 1 0 0 1 1 1 0 Autoinducer binding domain DSPc PF00782.20 EMC81361.1 - 5.3e-29 100.7 0.0 8.6e-29 100.0 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DEK_C PF08766.11 EMC81361.1 - 6.1e-14 51.7 0.3 9.3e-14 51.1 0.3 1.3 1 0 0 1 1 1 1 DEK C terminal domain UPF0149 PF03695.13 EMC81361.1 - 0.029 14.7 0.1 0.066 13.5 0.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0149) Y_phosphatase PF00102.27 EMC81361.1 - 0.1 12.1 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Pkinase PF00069.25 EMC81362.1 - 1.6e-70 237.5 0.0 1.2e-69 234.6 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81362.1 - 2.4e-27 95.8 0.0 3.7e-27 95.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.19 EMC81362.1 - 2.1e-17 63.5 3.9 3.6e-17 62.7 3.9 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain PH PF00169.29 EMC81362.1 - 3.4e-07 30.7 0.0 6.2e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 EMC81362.1 - 0.0032 16.8 0.0 0.0051 16.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like HTH_WhiA PF02650.14 EMC81362.1 - 0.051 13.9 0.9 0.15 12.4 0.3 2.0 2 0 0 2 2 2 0 WhiA C-terminal HTH domain Pkinase_fungal PF17667.1 EMC81362.1 - 0.11 11.3 0.0 0.23 10.2 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase PHD_4 PF16866.5 EMC81363.1 - 1.7e-21 76.0 12.0 1.7e-21 76.0 12.0 2.7 2 0 0 2 2 2 1 PHD-finger zf-CXXC PF02008.20 EMC81363.1 - 1.3e-12 47.5 21.5 1.3e-12 47.5 21.5 2.8 2 0 0 2 2 2 1 CXXC zinc finger domain JHD PF17811.1 EMC81363.1 - 3e-10 40.5 0.1 7.2e-10 39.3 0.1 1.6 1 0 0 1 1 1 1 Jumonji helical domain F-box PF00646.33 EMC81363.1 - 7.5e-09 35.3 4.4 7.5e-09 35.3 4.4 2.9 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EMC81363.1 - 3e-08 33.4 6.5 6.8e-08 32.3 6.5 1.6 1 0 0 1 1 1 1 F-box-like JmjC PF02373.22 EMC81363.1 - 3.3e-05 24.3 3.9 0.0003 21.2 0.7 3.2 2 1 0 2 2 2 1 JmjC domain, hydroxylase LRR_6 PF13516.6 EMC81363.1 - 9.2e-05 22.2 6.2 4.2 7.7 0.1 6.0 6 0 0 6 6 6 2 Leucine Rich repeat Cupin_8 PF13621.6 EMC81363.1 - 0.0076 16.0 0.1 0.12 12.1 0.1 2.3 1 1 0 1 1 1 1 Cupin-like domain LRR_4 PF12799.7 EMC81363.1 - 0.09 13.2 8.6 0.25 11.8 1.8 4.3 2 2 2 4 4 4 0 Leucine Rich repeats (2 copies) Cupin_1 PF00190.22 EMC81363.1 - 0.19 11.3 0.0 0.35 10.5 0.0 1.3 1 0 0 1 1 1 0 Cupin Ras PF00071.22 EMC81364.1 - 5.1e-38 130.2 0.0 6.8e-38 129.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC81364.1 - 9e-14 51.7 0.0 1.4e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC81364.1 - 0.0005 19.6 0.0 0.00058 19.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family 7tm_1 PF00001.21 EMC81365.1 - 4.5e-13 49.1 31.8 8.7e-13 48.2 31.8 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC81365.1 - 6.3 6.3 34.1 0.019 14.6 20.0 2.4 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.21 EMC81366.1 - 2.3e-10 40.3 34.4 5e-10 39.2 34.4 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 EMC81367.1 - 5.8e-08 32.4 17.9 8.1e-08 31.9 17.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 EMC81368.1 - 2e-07 30.6 12.5 2e-07 30.6 12.5 2.9 1 1 2 3 3 3 3 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 EMC81369.1 - 2.5e-11 43.4 28.0 9.6e-10 38.2 28.0 2.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC81369.1 - 1.9e-05 24.4 23.8 1.9e-05 24.4 23.8 2.3 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF2953 PF11167.8 EMC81369.1 - 0.0069 16.4 1.5 0.027 14.5 0.1 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2953) 7tm_1 PF00001.21 EMC81370.1 - 6.8e-14 51.8 26.2 1.1e-12 47.8 26.2 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC81370.1 - 6.7e-08 32.5 24.9 1.8e-07 31.1 24.9 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF2953 PF11167.8 EMC81370.1 - 0.029 14.4 0.3 0.029 14.4 0.3 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2953) 7TM_GPCR_Srbc PF10316.9 EMC81370.1 - 0.21 11.0 23.1 0.026 14.0 16.1 2.1 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srbc 7tm_1 PF00001.21 EMC81371.1 - 1.2e-11 44.5 25.3 3.3e-09 36.5 25.3 2.2 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srbc PF10316.9 EMC81371.1 - 3.9e-05 23.3 8.0 3.9e-05 23.3 8.0 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc DUF2953 PF11167.8 EMC81371.1 - 0.07 13.2 0.2 0.07 13.2 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2953) PIG-P PF08510.12 EMC81371.1 - 8.8 6.3 10.9 25 4.8 10.9 1.8 1 0 0 1 1 1 0 PIG-P 7tm_1 PF00001.21 EMC81372.1 - 2.5e-16 59.8 21.0 5.3e-16 58.7 21.0 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srbc PF10316.9 EMC81372.1 - 0.063 12.8 20.0 0.3 10.6 19.1 2.1 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srbc 7tm_4 PF13853.6 EMC81373.1 - 5.6e-36 124.7 22.0 9.4e-36 124.0 22.0 1.3 1 1 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC81373.1 - 2e-21 76.5 14.1 2e-21 76.5 14.1 2.2 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC81373.1 - 0.00092 18.9 14.9 0.00092 18.9 14.9 2.5 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 EMC81373.1 - 0.0011 18.4 18.6 0.0028 17.1 18.3 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC81374.1 - 1.1e-44 153.3 22.1 1.4e-44 152.9 22.1 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC81374.1 - 4.1e-26 91.9 29.2 6.2e-26 91.3 29.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC81374.1 - 0.00014 21.6 17.9 0.00014 21.6 17.9 2.6 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 EMC81374.1 - 0.00065 19.2 26.0 0.0016 17.9 26.0 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx SLC3A2_N PF16028.5 EMC81374.1 - 0.063 12.9 4.0 0.32 10.6 0.2 2.5 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus 7tm_4 PF13853.6 EMC81375.1 - 2.8e-50 171.6 18.7 3.4e-50 171.4 18.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC81375.1 - 3.3e-28 98.7 17.7 4.3e-28 98.4 17.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC81375.1 - 0.0096 15.6 11.2 0.0096 15.6 11.2 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC81376.1 - 3.8e-51 174.5 24.9 4.8e-51 174.1 24.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC81376.1 - 4.1e-28 98.4 27.4 7.1e-28 97.7 27.4 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC81376.1 - 0.00021 20.7 26.8 0.0011 18.4 26.8 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx UPF0542 PF15086.6 EMC81376.1 - 0.092 12.7 1.0 0.33 10.9 1.0 1.9 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 7TM_GPCR_Srx PF10328.9 EMC81376.1 - 0.58 9.7 32.9 1.9 8.0 32.4 1.9 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx SLC3A2_N PF16028.5 EMC81376.1 - 8.1 6.1 6.5 1.8 8.2 1.5 2.5 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus 7tm_4 PF13853.6 EMC81377.1 - 1.7e-53 182.2 16.2 2.1e-53 181.9 16.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC81377.1 - 8.8e-26 90.8 15.8 1.3e-25 90.3 15.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ferritin PF00210.24 EMC81378.1 - 8.2e-39 132.8 5.3 9.8e-39 132.5 5.3 1.1 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.17 EMC81378.1 - 0.007 16.8 1.3 0.009 16.4 1.3 1.3 1 1 0 1 1 1 1 Rubrerythrin Mad3_BUB1_I_2 PF17014.5 EMC81378.1 - 0.13 12.4 2.0 1 9.5 0.4 2.1 2 0 0 2 2 2 0 Putative Mad3/BUB1 like region 1 protein IcmF_C PF06744.12 EMC81378.1 - 0.15 11.6 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Type VI secretion protein IcmF C-terminal Bestrophin PF01062.21 EMC81379.1 - 1.1e-92 310.6 0.5 1.4e-92 310.3 0.5 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Sec2p PF06428.11 EMC81380.1 - 6.9e-09 35.6 9.8 6.9e-09 35.6 9.8 2.1 1 1 1 2 2 2 1 GDP/GTP exchange factor Sec2p Spc7 PF08317.11 EMC81380.1 - 0.027 13.3 11.9 0.044 12.7 11.9 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein IATP PF04568.12 EMC81380.1 - 0.045 14.2 2.2 0.13 12.7 2.2 1.9 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP AviRa PF11599.8 EMC81380.1 - 0.092 12.2 0.8 0.13 11.7 0.8 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa UPF0242 PF06785.11 EMC81380.1 - 0.1 12.7 10.6 0.17 12.0 10.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4407 PF14362.6 EMC81380.1 - 0.43 9.9 3.9 0.63 9.3 3.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 EMC81380.1 - 0.62 10.1 15.6 0.6 10.2 14.0 1.6 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein HSP70 PF00012.20 EMC81380.1 - 0.69 8.0 6.5 1 7.4 6.5 1.2 1 0 0 1 1 1 0 Hsp70 protein DUF2203 PF09969.9 EMC81380.1 - 1.7 9.4 6.1 4.6 8.0 6.1 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Uds1 PF15456.6 EMC81380.1 - 1.8 8.7 13.4 1.1 9.5 6.0 2.4 1 1 1 2 2 2 0 Up-regulated During Septation DUF1664 PF07889.12 EMC81380.1 - 2 8.4 4.2 7.5 6.6 4.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.15 EMC81380.1 - 2.1 7.8 6.3 2.9 7.4 6.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Syntaxin-6_N PF09177.11 EMC81380.1 - 4 8.1 8.1 9.5 6.8 6.9 2.3 2 1 0 2 2 2 0 Syntaxin 6, N-terminal OmpH PF03938.14 EMC81380.1 - 8 6.8 11.7 23 5.3 11.8 1.7 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) FA_desaturase PF00487.24 EMC81381.1 - 6.8e-28 98.2 22.7 7.9e-27 94.7 19.4 2.9 1 1 1 2 2 2 2 Fatty acid desaturase Cyt-b5 PF00173.28 EMC81381.1 - 1.7e-21 76.1 0.0 3.3e-21 75.2 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain CHDNT PF08073.12 EMC81381.1 - 0.066 13.2 0.0 0.22 11.5 0.0 1.9 1 0 0 1 1 1 0 CHDNT (NUC034) domain FA_desaturase PF00487.24 EMC81382.1 - 1.4e-32 113.6 35.9 1.4e-32 113.6 30.8 2.0 1 1 1 2 2 2 2 Fatty acid desaturase Cyt-b5 PF00173.28 EMC81382.1 - 8e-20 70.8 0.0 1.6e-19 69.8 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain CrgA PF06781.12 EMC81382.1 - 0.63 10.1 3.7 0.64 10.1 0.0 2.4 2 1 0 2 2 2 0 Cell division protein CrgA FA_desaturase PF00487.24 EMC81383.1 - 2.5e-35 122.6 20.8 2.5e-35 122.6 20.8 2.0 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 EMC81383.1 - 8.9e-24 83.4 0.1 1.6e-23 82.6 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Sigma_reg_N PF13800.6 EMC81383.1 - 0.12 12.6 3.1 0.31 11.4 0.5 2.5 2 0 0 2 2 2 0 Sigma factor regulator N-terminal FA_desaturase PF00487.24 EMC81384.1 - 3.4e-32 112.3 21.8 3.4e-32 112.3 21.8 1.7 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 EMC81384.1 - 6.2e-22 77.5 0.0 1.1e-21 76.7 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Catalase PF00199.19 EMC81385.1 - 1.3e-197 656.6 0.0 1.7e-197 656.1 0.0 1.2 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EMC81385.1 - 2.8e-20 72.3 1.0 8.3e-20 70.8 0.3 2.1 2 0 0 2 2 2 1 Catalase-related immune-responsive BTB PF00651.31 EMC81386.1 - 2.3e-24 85.7 0.8 6.4e-24 84.3 0.6 1.9 1 1 1 2 2 2 1 BTB/POZ domain Ank_2 PF12796.7 EMC81386.1 - 1.5e-20 73.6 0.0 2.4e-11 44.0 0.0 4.0 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC81386.1 - 2.1e-16 60.0 0.4 0.00013 22.4 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC81386.1 - 1e-15 56.2 0.9 5.4e-05 23.3 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 EMC81386.1 - 1.9e-13 50.2 5.0 2.1e-05 24.7 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EMC81386.1 - 5.4e-11 42.5 1.5 0.0028 17.9 0.0 5.0 4 1 1 5 5 5 3 Ankyrin repeats (many copies) BACK PF07707.15 EMC81386.1 - 0.0008 19.5 0.1 0.0047 17.0 0.0 2.4 2 0 0 2 2 2 1 BTB And C-terminal Kelch LAGLIDADG_2 PF03161.13 EMC81386.1 - 0.077 13.0 0.7 0.19 11.7 0.7 1.7 1 0 0 1 1 1 0 LAGLIDADG DNA endonuclease family LIM PF00412.22 EMC81388.1 - 1.2e-28 99.0 20.5 1.1e-15 57.6 9.0 2.0 2 0 0 2 2 2 2 LIM domain C1_4 PF07975.12 EMC81388.1 - 0.019 15.2 5.4 0.019 15.2 5.4 2.6 2 1 0 2 2 2 0 TFIIH C1-like domain Churchill PF06573.11 EMC81388.1 - 0.091 13.1 4.8 1.5 9.1 1.0 2.2 2 0 0 2 2 2 0 Churchill protein TDH PF03347.13 EMC81388.1 - 0.12 11.9 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Vibrio thermostable direct hemolysin TNFR_c6 PF00020.18 EMC81388.1 - 6 7.4 12.7 5.2 7.6 0.5 3.3 4 0 0 4 4 4 0 TNFR/NGFR cysteine-rich region DUF525 PF04379.14 EMC81389.1 - 1.8e-29 101.8 0.1 8.1e-29 99.7 0.0 2.1 2 0 0 2 2 2 1 ApaG domain SMI1_KNR4 PF09346.10 EMC81389.1 - 3e-10 40.6 0.0 7e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) SUKH_6 PF14568.6 EMC81389.1 - 0.0031 17.9 0.0 0.0093 16.4 0.0 1.9 1 1 0 1 1 1 1 SMI1-KNR4 cell-wall SUKH_5 PF14567.6 EMC81389.1 - 0.039 13.7 0.0 0.088 12.5 0.0 1.6 1 0 0 1 1 1 0 SMI1-KNR4 cell-wall UPAR_LY6 PF00021.21 EMC81390.1 - 0.022 15.4 14.0 0.1 13.3 14.0 2.0 1 1 0 1 1 1 0 u-PAR/Ly-6 domain Actin PF00022.19 EMC81391.1 - 8e-150 499.0 0.0 2.6e-149 497.3 0.0 1.7 1 1 0 1 1 1 1 Actin RVT_1 PF00078.27 EMC81392.1 - 0.0018 17.8 0.1 0.0025 17.4 0.1 1.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HS1_rep PF02218.15 EMC81393.1 - 6.6e-106 346.3 62.4 4.9e-21 74.8 3.7 7.7 7 0 0 7 7 7 7 Repeat in HS1/Cortactin SH3_9 PF14604.6 EMC81393.1 - 3e-17 62.2 0.2 5.9e-17 61.3 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC81393.1 - 2e-16 59.3 0.2 4.8e-16 58.1 0.2 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC81393.1 - 1.6e-09 37.3 0.0 3.2e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain TMEM210 PF15195.6 EMC81393.1 - 5.9e-07 29.9 2.9 7.7 7.0 0.0 6.0 2 2 4 6 6 6 2 TMEM210 family AMP-binding_C_2 PF14535.6 EMC81393.1 - 0.027 14.8 0.6 0.51 10.7 0.6 2.7 2 1 0 2 2 2 0 AMP-binding enzyme C-terminal domain Endonuc_subdom PF09062.10 EMC81393.1 - 0.04 14.7 1.5 21 6.0 0.0 4.2 2 1 2 4 4 4 0 PI-PfuI Endonuclease subdomain Tho2 PF11262.8 EMC81393.1 - 0.44 9.7 6.7 0.84 8.8 6.7 1.4 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 PV-1 PF06637.11 EMC81393.1 - 1.5 7.6 8.3 2.4 6.9 8.3 1.2 1 0 0 1 1 1 0 PV-1 protein (PLVAP) DUF4551 PF15087.6 EMC81393.1 - 4.4 6.0 8.1 7 5.4 8.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Casc1_N PF15927.5 EMC81393.1 - 9.7 5.8 16.7 20 4.8 16.7 1.5 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus DED PF01335.21 EMC81394.1 - 7.1e-20 71.1 5.6 1.4e-19 70.1 5.6 1.5 1 0 0 1 1 1 1 Death effector domain Death PF00531.22 EMC81394.1 - 8.5e-19 67.5 1.4 9e-18 64.2 0.2 2.1 2 0 0 2 2 2 1 Death domain Anoctamin PF04547.12 EMC81395.1 - 4.5e-136 454.3 10.9 6.6e-136 453.7 10.9 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 EMC81395.1 - 3.6e-84 282.0 0.3 3.6e-84 282.0 0.3 2.4 3 0 0 3 3 3 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin CbtA PF09490.10 EMC81395.1 - 0.01 15.6 0.0 0.033 14.0 0.0 1.8 1 1 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) Ni_hydr_CYTB PF01292.20 EMC81395.1 - 0.061 12.9 0.2 0.19 11.3 0.2 1.8 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 TMEM43 PF07787.12 EMC81395.1 - 0.063 12.7 0.6 0.13 11.6 0.0 1.8 2 0 0 2 2 2 0 Transmembrane protein 43 DUF2207 PF09972.9 EMC81395.1 - 0.15 10.8 12.9 0.26 10.0 2.1 2.9 2 1 1 3 3 3 0 Predicted membrane protein (DUF2207) FGF PF00167.18 EMC81396.1 - 3.5e-50 169.3 0.3 4.4e-50 169.0 0.3 1.1 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.13 EMC81396.1 - 0.11 12.8 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 Fascin domain FGF PF00167.18 EMC81397.1 - 4.3e-32 110.9 0.0 8.7e-32 109.9 0.0 1.5 1 1 0 1 1 1 1 Fibroblast growth factor FGF PF00167.18 EMC81398.1 - 9.5e-19 67.7 0.0 1.1e-18 67.5 0.0 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Yae1_N PF09811.9 EMC81399.1 - 1.7e-12 46.8 5.2 3.5e-12 45.8 5.2 1.5 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Cyclin_N PF00134.23 EMC81400.1 - 3.1e-38 130.4 2.4 3.1e-38 130.4 2.4 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EMC81400.1 - 1.8e-20 73.2 2.8 3.5e-20 72.3 0.4 2.3 2 1 1 3 3 3 1 Cyclin, C-terminal domain Ion_trans PF00520.31 EMC81401.1 - 1.3e-50 172.0 43.7 4.2e-26 91.7 20.3 2.3 2 0 0 2 2 2 2 Ion transport protein DUF1331 PF07048.11 EMC81401.1 - 1.6 8.5 3.8 0.86 9.3 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1331) PKD_channel PF08016.12 EMC81401.1 - 1.7 7.2 39.1 0.25 10.0 6.9 4.5 3 2 1 4 4 4 0 Polycystin cation channel CN_hydrolase PF00795.22 EMC81402.1 - 5.4e-41 140.7 0.0 7.5e-41 140.2 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 EMC81402.1 - 3.6e-26 91.8 0.0 8.5e-26 90.5 0.0 1.6 1 1 0 1 1 1 1 NAD synthase Asn_synthase PF00733.21 EMC81402.1 - 0.017 14.8 0.0 0.035 13.8 0.0 1.4 1 0 0 1 1 1 0 Asparagine synthase ERG4_ERG24 PF01222.17 EMC81403.1 - 1.1e-94 317.7 27.3 1.4e-94 317.4 27.3 1.1 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EMC81403.1 - 0.00056 19.5 0.4 0.00056 19.5 0.4 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) ICMT PF04140.14 EMC81403.1 - 0.013 15.9 1.8 0.026 14.9 0.1 2.4 2 0 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Orf78 PF06024.12 EMC81403.1 - 0.18 12.1 0.8 0.42 10.9 0.0 2.1 2 0 0 2 2 2 0 Orf78 (ac78) Ank_2 PF12796.7 EMC81404.1 - 4.9e-33 113.6 0.3 2.4e-13 50.5 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC81404.1 - 2.9e-31 107.4 8.1 2.3e-07 31.2 0.1 5.1 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC81404.1 - 6.9e-28 96.4 0.9 3.4e-08 33.6 0.3 4.7 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC81404.1 - 2.3e-26 88.9 0.1 8.3e-05 22.7 0.0 7.8 7 0 0 7 7 7 5 Ankyrin repeat DHHC PF01529.20 EMC81404.1 - 2e-22 79.8 14.6 2e-22 79.8 14.6 3.0 2 1 0 2 2 2 1 DHHC palmitoyltransferase Ank PF00023.30 EMC81404.1 - 2.7e-22 78.1 2.1 0.00014 22.1 0.0 6.9 7 0 0 7 7 7 5 Ankyrin repeat zf-RanBP PF00641.18 EMC81404.1 - 0.3 10.5 2.5 1 8.7 2.5 1.9 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others LIM PF00412.22 EMC81405.1 - 2.5e-29 101.2 24.8 2.1e-16 59.9 4.2 2.1 2 0 0 2 2 2 2 LIM domain zf_UBZ PF18439.1 EMC81405.1 - 0.03 13.9 13.6 0.58 9.8 0.1 4.4 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger DUF3718 PF12514.8 EMC81405.1 - 0.05 13.8 0.9 0.079 13.1 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3718) Zn_ribbon_2 PF12674.7 EMC81405.1 - 0.11 13.2 13.2 0.37 11.5 1.4 2.6 2 1 0 2 2 2 0 Putative zinc ribbon domain zf-ACC PF17848.1 EMC81405.1 - 0.13 12.4 0.4 0.13 12.4 0.4 3.7 4 0 0 4 4 4 0 Acetyl-coA carboxylase zinc finger domain zf-TFIIB PF13453.6 EMC81405.1 - 0.75 9.2 0.1 0.75 9.2 0.1 3.7 4 1 0 4 4 4 0 Transcription factor zinc-finger DUF2688 PF10892.8 EMC81405.1 - 0.77 9.3 6.0 2.8 7.5 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2688) zf-C2H2_6 PF13912.6 EMC81405.1 - 0.99 9.5 0.1 0.99 9.5 0.1 4.1 4 1 0 4 4 4 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 EMC81405.1 - 4.7 7.4 21.4 3.1 8.0 2.6 4.0 3 1 0 3 3 3 0 Zinc ribbon domain zf-FPG_IleRS PF06827.14 EMC81405.1 - 7.4 6.5 15.5 5.3 7.0 0.7 3.9 4 0 0 4 4 4 0 Zinc finger found in FPG and IleRS E2F_TDP PF02319.20 EMC81406.1 - 1.5e-42 143.4 0.5 1.1e-20 73.4 0.0 2.6 2 0 0 2 2 2 2 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.19 EMC81406.1 - 0.00025 20.9 0.1 0.00081 19.2 0.0 1.8 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB B-block_TFIIIC PF04182.12 EMC81406.1 - 0.045 13.9 0.2 15 5.8 0.0 2.7 2 0 0 2 2 2 0 B-block binding subunit of TFIIIC Homeodomain PF00046.29 EMC81407.1 - 7.8e-21 73.7 4.9 8.9e-21 73.5 3.7 1.7 2 0 0 2 2 2 1 Homeodomain DUF2986 PF11661.8 EMC81407.1 - 0.015 15.8 1.4 0.015 15.8 1.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2986) Homeobox_KN PF05920.11 EMC81407.1 - 0.016 15.1 0.1 0.034 14.0 0.1 1.5 1 0 0 1 1 1 0 Homeobox KN domain Homez PF11569.8 EMC81407.1 - 0.12 11.8 0.2 0.34 10.4 0.2 1.7 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez YdaS_antitoxin PF15943.5 EMC81407.1 - 0.16 11.9 0.0 0.29 11.1 0.0 1.3 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT PrmA PF06325.13 EMC81408.1 - 3.6e-11 43.0 0.0 6.3e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EMC81408.1 - 1.9e-10 41.3 0.3 5.7e-10 39.8 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC81408.1 - 2.4e-09 37.1 0.0 7.2e-09 35.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EMC81408.1 - 3.4e-09 36.1 0.0 4.6e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_11 PF08241.12 EMC81408.1 - 3.7e-08 33.9 0.0 1.3e-07 32.2 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC81408.1 - 5.6e-07 29.5 0.0 4.6e-06 26.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EMC81408.1 - 8.5e-06 25.4 0.0 1.7e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain TehB PF03848.14 EMC81408.1 - 0.00057 19.4 0.1 0.001 18.5 0.1 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_12 PF08242.12 EMC81408.1 - 0.00063 20.4 0.0 0.0015 19.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EMC81408.1 - 0.00068 19.8 0.5 0.0066 16.6 0.1 2.3 1 1 0 2 2 2 1 FtsJ-like methyltransferase zf-C2H2_2 PF12756.7 EMC81408.1 - 0.0014 18.9 0.7 0.0044 17.3 0.7 1.8 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) Met_10 PF02475.16 EMC81408.1 - 0.0014 18.4 0.3 0.0044 16.8 0.1 1.8 2 0 0 2 2 2 1 Met-10+ like-protein Methyltransf_18 PF12847.7 EMC81408.1 - 0.0015 18.4 0.1 0.004 17.1 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EMC81408.1 - 0.0066 15.9 0.1 0.016 14.7 0.1 1.6 1 0 0 1 1 1 1 Putative methyltransferase PCMT PF01135.19 EMC81408.1 - 0.0086 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) ATP-synt_B PF00430.18 EMC81408.1 - 0.021 14.9 4.3 0.037 14.1 4.3 1.2 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Methyltransf_16 PF10294.9 EMC81408.1 - 0.037 13.8 0.0 0.072 12.8 0.0 1.5 1 0 0 1 1 1 0 Lysine methyltransferase CMAS PF02353.20 EMC81408.1 - 0.039 13.3 0.0 0.066 12.5 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Dna2 PF08696.11 EMC81408.1 - 0.042 13.6 0.0 1.8 8.3 0.0 2.4 2 0 0 2 2 2 0 DNA replication factor Dna2 Cons_hypoth95 PF03602.15 EMC81408.1 - 0.051 13.2 0.0 0.099 12.3 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_24 PF13578.6 EMC81408.1 - 0.076 14.0 0.0 0.54 11.3 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain PRMT5 PF05185.16 EMC81408.1 - 0.08 12.8 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Methyltransf_32 PF13679.6 EMC81408.1 - 0.13 12.2 0.6 0.24 11.4 0.0 1.6 2 0 0 2 2 1 0 Methyltransferase domain zf-C2H2_4 PF13894.6 EMC81408.1 - 0.25 12.3 3.4 0.96 10.5 2.4 2.6 3 0 0 3 3 1 0 C2H2-type zinc finger SNF PF00209.18 EMC81409.1 - 9.3e-216 717.5 42.4 2.7e-215 716.0 42.4 1.6 1 1 0 1 1 1 1 Sodium:neurotransmitter symporter family EGF_CA PF07645.15 EMC81410.1 - 3e-26 91.3 54.6 7.6e-11 42.0 5.3 11.1 10 2 2 12 12 6 4 Calcium-binding EGF domain VWC PF00093.18 EMC81410.1 - 5.3e-20 71.5 78.2 1.7e-10 41.0 15.5 9.9 6 1 2 8 8 6 5 von Willebrand factor type C domain EGF_3 PF12947.7 EMC81410.1 - 6.8e-12 45.4 36.7 2.5e-09 37.2 14.7 10.8 10 1 0 10 10 8 4 EGF domain cEGF PF12662.7 EMC81410.1 - 5.8e-09 35.7 11.8 1.4e-06 28.1 2.7 11.2 11 0 0 11 11 11 5 Complement Clr-like EGF-like Laminin_G_2 PF02210.24 EMC81410.1 - 2.1e-08 34.8 0.0 3.5e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_3 PF13385.6 EMC81410.1 - 9.2e-07 29.1 0.0 1.5e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.27 EMC81410.1 - 1.2e-05 25.5 36.5 0.0012 19.1 3.0 11.5 11 0 0 11 11 7 4 EGF-like domain TILa PF12714.7 EMC81410.1 - 1.2e-05 25.1 29.5 3.3e-05 23.8 11.1 11.2 7 4 4 11 11 7 4 TILa domain Laminin_G_1 PF00054.23 EMC81410.1 - 5.5e-05 23.4 0.0 0.00014 22.0 0.0 1.6 1 1 0 1 1 1 1 Laminin G domain hEGF PF12661.7 EMC81410.1 - 0.00023 21.7 29.0 0.0019 18.7 4.3 12.8 12 1 0 12 12 10 5 Human growth factor-like EGF EGF_2 PF07974.13 EMC81410.1 - 0.0016 18.7 13.6 0.0016 18.7 13.6 12.3 10 2 1 11 11 9 2 EGF-like domain FXa_inhibition PF14670.6 EMC81410.1 - 0.0052 17.0 6.3 0.0052 17.0 6.3 11.2 8 3 2 10 10 6 3 Coagulation Factor Xa inhibitory site DUF3734 PF12536.8 EMC81410.1 - 0.18 12.1 0.0 0.43 10.9 0.0 1.5 1 0 0 1 1 1 0 Patatin phospholipase RhoGAP PF00620.27 EMC81412.1 - 7.4e-30 103.8 0.1 1.3e-29 103.0 0.1 1.3 1 1 0 1 1 1 1 RhoGAP domain TRP PF06011.12 EMC81412.1 - 0.045 12.5 0.0 0.045 12.5 0.0 1.0 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel Steroid_dh PF02544.16 EMC81413.1 - 4e-20 72.3 5.9 4e-20 72.3 5.9 1.7 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase RVT_1 PF00078.27 EMC81414.1 - 0.009 15.5 0.1 0.014 14.9 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) NHL PF01436.21 EMC81415.1 - 0.062 13.4 1.1 1.3 9.2 0.1 3.8 4 0 0 4 4 4 0 NHL repeat AT_hook PF02178.19 EMC81417.1 - 0.00035 20.1 23.1 0.0023 17.6 3.4 3.1 3 1 0 3 3 3 2 AT hook motif RFX5_DNA_bdg PF14621.6 EMC81417.1 - 9.6 5.9 13.2 9 6.0 10.5 1.8 1 1 1 2 2 2 0 RFX5 DNA-binding domain SelR PF01641.18 EMC81418.1 - 7.9e-54 180.9 0.2 9.9e-54 180.6 0.2 1.1 1 0 0 1 1 1 1 SelR domain zf-ribbon_3 PF13248.6 EMC81418.1 - 0.0049 16.2 1.0 0.49 9.9 0.1 2.8 2 0 0 2 2 2 1 zinc-ribbon domain Yippee-Mis18 PF03226.14 EMC81418.1 - 0.032 14.4 0.1 0.087 13.0 0.1 1.8 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DZR PF12773.7 EMC81418.1 - 0.037 14.1 0.3 0.35 10.9 0.3 2.4 1 1 1 2 2 2 0 Double zinc ribbon Zn_ribbon_SprT PF17283.2 EMC81418.1 - 0.041 13.8 1.0 0.56 10.2 1.0 2.5 1 1 0 1 1 1 0 SprT-like zinc ribbon domain zf-Mss51 PF13824.6 EMC81418.1 - 0.066 13.3 3.3 0.21 11.7 0.1 2.7 3 0 0 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 GFA PF04828.14 EMC81418.1 - 0.073 13.4 1.4 1.4 9.3 0.4 2.4 2 1 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme zinc_ribbon_10 PF10058.9 EMC81418.1 - 0.1 12.4 0.8 2.2 8.0 0.1 2.4 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein zinc_ribbon_2 PF13240.6 EMC81418.1 - 0.7 9.7 4.1 8 6.3 0.1 2.8 3 0 0 3 3 3 0 zinc-ribbon domain zf-tcix PF14952.6 EMC81418.1 - 1.1 8.9 6.5 25 4.6 0.2 3.3 3 0 0 3 3 3 0 Putative treble-clef, zinc-finger, Zn-binding DUF4682 PF15733.5 EMC81419.1 - 2.3e-43 147.7 2.6 4.8e-43 146.7 2.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4682) RabGAP-TBC PF00566.18 EMC81419.1 - 1.3e-36 126.2 1.3 1.6e-36 126.0 0.1 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain 60KD_IMP PF02096.20 EMC81419.1 - 0.018 14.9 0.4 0.018 14.9 0.4 2.3 3 0 0 3 3 3 0 60Kd inner membrane protein NYD-SP28 PF14772.6 EMC81420.1 - 0.033 14.2 0.6 0.051 13.6 0.5 1.3 1 1 0 1 1 1 0 Sperm tail RA PF00788.23 EMC81421.1 - 6.5e-22 78.0 0.2 6e-21 74.9 0.2 2.1 1 1 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Nore1-SARAH PF16517.5 EMC81421.1 - 9e-16 57.5 3.4 9e-16 57.5 3.4 1.8 2 0 0 2 2 2 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Ras_bdg_2 PF14847.6 EMC81421.1 - 0.012 15.9 0.1 0.024 15.0 0.1 1.7 1 1 0 1 1 1 0 Ras-binding domain of Byr2 Mst1_SARAH PF11629.8 EMC81421.1 - 0.062 13.4 1.0 0.14 12.2 1.0 1.6 1 0 0 1 1 1 0 C terminal SARAH domain of Mst1 RBD PF02196.15 EMC81421.1 - 0.15 12.2 0.0 0.34 11.0 0.0 1.7 1 0 0 1 1 1 0 Raf-like Ras-binding domain TBK1_CCD1 PF18394.1 EMC81422.1 - 1.8e-121 404.5 4.8 2.9e-121 403.9 4.8 1.3 1 0 0 1 1 1 1 TANK-binding kinase 1 coiled-coil domain 1 Pkinase PF00069.25 EMC81422.1 - 1.2e-45 156.0 0.0 2.8e-45 154.7 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain TBK1_ULD PF18396.1 EMC81422.1 - 1.6e-37 127.3 1.7 4.4e-37 125.9 1.7 1.8 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Pkinase_Tyr PF07714.17 EMC81422.1 - 6.6e-26 91.1 0.0 1.3e-25 90.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC81422.1 - 1e-06 27.9 0.0 4.7e-06 25.6 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EMC81422.1 - 8.8e-05 21.9 0.0 0.0016 17.8 0.0 2.5 3 0 0 3 3 3 1 Kinase-like ubiquitin PF00240.23 EMC81422.1 - 0.0017 18.1 0.1 0.0049 16.6 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin family RIO1 PF01163.22 EMC81422.1 - 0.0048 16.5 0.1 0.2 11.3 0.1 2.6 1 1 1 2 2 2 1 RIO1 family NPV_P10 PF05531.12 EMC81422.1 - 0.016 15.7 0.9 2.5 8.6 0.3 2.9 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein RPW8 PF05659.11 EMC81422.1 - 0.52 10.0 4.3 2.8 7.6 0.1 2.7 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF1664 PF07889.12 EMC81422.1 - 2.6 8.1 4.8 9 6.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Ribosomal_L18A PF01775.17 EMC81423.1 - 7e-57 190.8 0.1 8.7e-57 190.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A C12orf66_like PF09404.10 EMC81425.1 - 1.7e-234 778.6 7.6 2e-234 778.3 7.6 1.0 1 0 0 1 1 1 1 KICSTOR complex C12orf66 like Urb2 PF10441.9 EMC81425.1 - 0.057 13.3 0.6 0.14 12.1 0.3 1.6 1 1 0 1 1 1 0 Urb2/Npa2 family RNase_3_N PF18497.1 EMC81425.1 - 0.059 13.6 1.4 1.1 9.5 0.1 2.7 2 1 0 2 2 2 0 Ribonuclease III N-terminal domain Pox_I1 PF03289.13 EMC81425.1 - 0.12 11.5 0.5 0.76 8.8 0.1 2.1 2 0 0 2 2 2 0 Poxvirus protein I1 RhoGAP PF00620.27 EMC81426.1 - 1.2e-46 158.3 0.4 1.3e-45 154.9 0.0 2.7 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.23 EMC81426.1 - 3.8e-17 62.3 6.5 8.5e-17 61.2 5.3 2.3 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 EMC81426.1 - 5.1e-10 38.8 0.0 9.4e-10 38.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC81426.1 - 7.9e-10 38.4 0.0 1.4e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC81426.1 - 1.1e-08 34.6 0.0 2.3e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DASH_Dad3 PF08656.10 EMC81426.1 - 0.53 10.4 3.7 12 6.0 1.4 3.1 2 0 0 2 2 2 0 DASH complex subunit Dad3 FlaC_arch PF05377.11 EMC81426.1 - 0.61 10.5 6.1 0.2 12.0 1.1 2.9 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) FTZ PF03867.14 EMC81426.1 - 0.66 9.5 9.1 0.16 11.5 2.7 2.4 2 0 0 2 2 2 0 Fushi tarazu (FTZ), N-terminal region Exostosin PF03016.15 EMC81427.1 - 0.00012 21.4 0.0 0.00023 20.5 0.0 1.4 1 0 0 1 1 1 1 Exostosin family Flg_bbr_C PF06429.13 EMC81427.1 - 0.017 15.2 0.2 0.037 14.2 0.2 1.5 1 0 0 1 1 1 0 Flagellar basal body rod FlgEFG protein C-terminal PBSX_XtrA PF17356.2 EMC81427.1 - 0.027 14.3 0.1 0.063 13.2 0.1 1.5 1 0 0 1 1 1 0 Phage-like element PBSX protein XtrA DUF4508 PF14969.6 EMC81427.1 - 0.1 12.9 3.3 1 9.7 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4508) 7tm_1 PF00001.21 EMC81428.1 - 7.9e-22 77.8 1.3 9.9e-22 77.5 1.0 1.2 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1856 PF08983.10 EMC81428.1 - 6.8e-15 55.0 8.7 1.2e-14 54.3 8.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1856) 7tm_4 PF13853.6 EMC81428.1 - 0.00055 19.8 0.4 0.00066 19.5 0.4 1.1 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC81428.1 - 0.0017 18.0 0.1 0.0022 17.7 0.1 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF5134 PF17197.4 EMC81428.1 - 0.0024 17.8 0.2 0.0036 17.2 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5134) 7TM_GPCR_Srsx PF10320.9 EMC81428.1 - 0.021 14.2 0.7 0.026 13.9 0.7 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx Srg PF02118.21 EMC81428.1 - 0.034 13.8 0.3 0.043 13.5 0.3 1.1 1 0 0 1 1 1 0 Srg family chemoreceptor Amastin PF07344.11 EMC81428.1 - 0.048 13.5 0.5 0.081 12.8 0.5 1.4 1 0 0 1 1 1 0 Amastin surface glycoprotein 7TM_GPCR_Srv PF10323.9 EMC81428.1 - 0.12 11.7 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv PP2C PF00481.21 EMC81429.1 - 3.5e-27 95.7 0.0 4.5e-12 46.2 0.0 3.1 3 0 0 3 3 3 3 Protein phosphatase 2C SpoIIE PF07228.12 EMC81429.1 - 0.00013 21.9 0.0 0.16 11.8 0.0 2.3 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 EMC81429.1 - 0.02 14.6 0.0 0.13 11.9 0.0 2.2 1 1 0 1 1 1 0 Protein phosphatase 2C Glyco_hydro_38N PF01074.22 EMC81430.1 - 8.6e-81 271.5 3.6 1.3e-80 270.8 3.6 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EMC81430.1 - 9.8e-27 94.4 0.5 1.6e-26 93.7 0.5 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EMC81430.1 - 2.8e-18 65.8 0.0 6.8e-18 64.6 0.0 1.7 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 EMC81430.1 - 3.1e-09 36.8 0.0 8.6e-09 35.4 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Phage_30_3 PF08010.11 EMC81430.1 - 0.14 12.0 0.1 21 4.9 0.0 2.7 2 0 0 2 2 2 0 Bacteriophage protein GP30.3 S_100 PF01023.19 EMC81431.1 - 1.9e-19 69.1 0.2 5e-19 67.7 0.1 1.8 2 0 0 2 2 2 1 S-100/ICaBP type calcium binding domain EF-hand_6 PF13405.6 EMC81431.1 - 1.1e-07 31.1 0.5 0.00032 20.4 0.2 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 EMC81431.1 - 2.3e-07 31.1 0.3 2.9e-07 30.8 0.3 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EMC81431.1 - 2.1e-06 26.8 1.1 3e-05 23.3 0.5 2.4 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 EMC81431.1 - 0.00037 20.3 0.2 0.0005 19.8 0.2 1.3 1 0 0 1 1 1 1 EF-hand domain pair DEK_C PF08766.11 EMC81431.1 - 0.01 15.7 0.3 0.018 14.9 0.3 1.4 1 0 0 1 1 1 0 DEK C terminal domain EF-hand_4 PF12763.7 EMC81431.1 - 0.011 15.7 0.1 0.013 15.4 0.1 1.2 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.6 EMC81431.1 - 0.026 14.0 2.6 0.31 10.6 1.4 2.5 2 0 0 2 2 2 0 EF hand RabGAP-TBC PF00566.18 EMC81432.1 - 1.1e-49 169.0 0.0 2.6e-49 167.8 0.0 1.7 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SWIRM PF04433.17 EMC81433.1 - 0.04 14.3 0.6 0.12 12.7 0.0 2.1 2 1 0 2 2 2 0 SWIRM domain Pertussis_S1 PF02917.14 EMC81433.1 - 0.057 13.2 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Pertussis toxin, subunit 1 GrpE PF01025.19 EMC81434.1 - 3.4e-45 153.7 4.5 4.1e-45 153.4 4.5 1.1 1 0 0 1 1 1 1 GrpE Laminin_I PF06008.14 EMC81434.1 - 0.013 15.2 8.9 0.016 15.0 8.9 1.1 1 0 0 1 1 1 0 Laminin Domain I Cpn60_TCP1 PF00118.24 EMC81434.1 - 0.015 14.0 2.6 0.017 13.8 2.6 1.1 1 0 0 1 1 1 0 TCP-1/cpn60 chaperonin family MetJ PF01340.20 EMC81434.1 - 0.058 13.4 0.6 0.17 11.9 0.2 1.9 1 1 0 2 2 2 0 Met Apo-repressor, MetJ LOH1CR12 PF10158.9 EMC81434.1 - 0.078 13.0 1.6 0.11 12.5 1.6 1.3 1 0 0 1 1 1 0 Tumour suppressor protein DUF2205 PF10224.9 EMC81434.1 - 0.32 11.0 7.4 0.18 11.8 4.7 1.9 1 1 1 2 2 2 0 Short coiled-coil protein DUF1993 PF09351.10 EMC81434.1 - 0.34 11.0 3.0 10 6.2 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1993) DUF3391 PF11871.8 EMC81434.1 - 0.38 11.3 6.3 0.78 10.3 6.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) DUF3347 PF11827.8 EMC81434.1 - 0.39 10.9 7.5 0.49 10.6 7.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) Connexin PF00029.19 EMC81434.1 - 0.48 10.1 2.7 0.67 9.7 2.7 1.1 1 0 0 1 1 1 0 Connexin TERB2 PF15101.6 EMC81434.1 - 0.62 10.1 4.6 0.84 9.6 4.6 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 POX PF07526.11 EMC81434.1 - 1.3 9.6 7.3 2.3 8.8 7.0 1.4 1 1 0 1 1 1 0 Associated with HOX LMBR1 PF04791.16 EMC81434.1 - 8 5.2 4.8 9.3 5.0 4.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein TMPIT PF07851.13 EMC81434.1 - 9.6 5.3 8.3 13 4.9 8.3 1.2 1 0 0 1 1 1 0 TMPIT-like protein Sortilin-Vps10 PF15902.5 EMC81435.1 - 7.5e-95 318.3 0.4 1.2e-94 317.7 0.4 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EMC81435.1 - 1e-36 126.9 2.7 1.5e-36 126.3 2.7 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal PKD PF00801.20 EMC81435.1 - 1.4e-07 31.3 0.0 1.8e-06 27.7 0.0 2.6 3 0 0 3 3 3 1 PKD domain BNR PF02012.20 EMC81435.1 - 0.013 15.4 10.7 2.4 8.5 0.3 5.1 5 0 0 5 5 5 0 BNR/Asp-box repeat PH PF00169.29 EMC81436.1 - 4.5e-26 91.4 1.7 9e-13 48.7 1.0 2.7 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 EMC81436.1 - 1.3e-05 25.5 2.8 0.027 14.9 0.0 3.7 3 1 0 3 3 3 2 Pleckstrin homology domain PH_9 PF15410.6 EMC81436.1 - 0.00034 20.9 1.3 1.2 9.5 0.5 4.1 2 2 0 2 2 2 1 Pleckstrin homology domain Sharpin_PH PF16764.5 EMC81436.1 - 0.0039 16.9 0.2 0.013 15.2 0.0 1.9 2 0 0 2 2 2 1 Sharpin PH domain Spc7 PF08317.11 EMC81436.1 - 0.14 11.1 15.5 0.26 10.1 15.5 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Nup188_C PF18378.1 EMC81436.1 - 0.91 8.3 3.9 1.5 7.6 3.9 1.2 1 0 0 1 1 1 0 Nuclear pore protein NUP188 C-terminal domain Prefoldin_2 PF01920.20 EMC81436.1 - 4 7.5 19.9 0.5 10.3 4.7 3.0 3 0 0 3 3 3 0 Prefoldin subunit AbLIM_anchor PF16182.5 EMC81437.1 - 6.4e-120 401.4 29.8 9.1e-79 266.0 22.8 2.1 1 1 1 2 2 2 2 Putative adherens-junction anchoring region of AbLIM LIM PF00412.22 EMC81437.1 - 2.9e-40 136.3 44.0 1.6e-14 53.8 3.6 4.3 4 0 0 4 4 4 4 LIM domain VHP PF02209.19 EMC81437.1 - 5.4e-16 58.4 2.5 1.1e-15 57.4 2.5 1.6 1 0 0 1 1 1 1 Villin headpiece domain TPR_12 PF13424.6 EMC81438.1 - 2.2e-15 56.7 39.0 5.2e-05 23.4 4.6 7.2 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 EMC81438.1 - 4.9e-05 23.1 45.7 0.32 11.2 0.4 11.2 11 0 0 11 11 11 4 Tetratricopeptide repeat TPR_8 PF13181.6 EMC81438.1 - 5.5e-05 23.1 54.7 0.039 14.2 0.2 12.0 14 1 1 15 15 15 4 Tetratricopeptide repeat TPR_1 PF00515.28 EMC81438.1 - 0.00023 20.8 36.3 0.24 11.3 0.1 10.0 11 0 0 11 11 11 4 Tetratricopeptide repeat SH3_1 PF00018.28 EMC81438.1 - 0.0021 17.6 0.5 0.0049 16.4 0.0 1.9 2 0 0 2 2 2 1 SH3 domain TPR_10 PF13374.6 EMC81438.1 - 0.0034 17.2 18.0 0.31 11.0 0.4 7.6 8 0 0 8 8 8 2 Tetratricopeptide repeat SH3_2 PF07653.17 EMC81438.1 - 0.0092 15.7 0.0 0.024 14.3 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain TPR_7 PF13176.6 EMC81438.1 - 0.039 14.0 0.2 0.039 14.0 0.2 8.4 9 1 0 10 10 10 0 Tetratricopeptide repeat Csd3_N PF18059.1 EMC81438.1 - 0.068 13.7 0.1 0.23 12.0 0.1 1.9 1 0 0 1 1 1 0 Csd3 N-terminal TPR_19 PF14559.6 EMC81438.1 - 0.16 12.5 17.8 0.28 11.7 0.1 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat Trypsin_2 PF13365.6 EMC81439.1 - 4.3e-29 102.4 0.2 6.9e-29 101.7 0.2 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EMC81439.1 - 1e-14 54.9 0.0 1.7e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 Trypsin PDZ_6 PF17820.1 EMC81439.1 - 4.7e-13 48.8 0.0 5.1e-12 45.5 0.0 2.3 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 EMC81439.1 - 7.2e-11 42.3 0.1 3.3e-10 40.1 0.0 2.1 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 EMC81439.1 - 3.1e-09 37.1 0.0 1e-08 35.4 0.0 2.0 1 0 0 1 1 1 1 PDZ domain IGFBP PF00219.18 EMC81439.1 - 6.6e-09 36.3 22.0 6.6e-09 36.3 22.0 2.0 2 0 0 2 2 2 1 Insulin-like growth factor binding protein Kazal_2 PF07648.15 EMC81439.1 - 9.6e-07 28.8 1.6 2.9e-06 27.3 1.6 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EMC81439.1 - 4.8e-05 23.3 1.3 4.8e-05 23.3 1.3 2.6 2 1 0 2 2 2 1 Kazal-type serine protease inhibitor domain Peptidase_S46 PF10459.9 EMC81439.1 - 0.00011 21.0 2.1 0.063 11.9 0.2 2.1 2 0 0 2 2 2 2 Peptidase S46 Peptidase_S32 PF05579.13 EMC81439.1 - 0.0012 18.1 0.3 0.57 9.3 0.0 2.1 2 0 0 2 2 2 2 Equine arteritis virus serine endopeptidase S32 Tricorn_PDZ PF14685.6 EMC81439.1 - 0.0021 18.0 0.1 0.0066 16.4 0.0 1.8 2 0 0 2 2 2 1 Tricorn protease PDZ domain DUF31 PF01732.16 EMC81439.1 - 0.072 12.6 0.3 11 5.5 0.0 2.1 2 0 0 2 2 2 0 Putative peptidase (DUF31) ACOX PF01756.19 EMC81440.1 - 2.6e-49 167.2 0.0 4.4e-49 166.5 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 EMC81440.1 - 1.2e-15 57.4 0.0 1.9e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 EMC81440.1 - 5.8e-07 30.1 0.0 1.3e-06 29.0 0.0 1.7 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 EMC81440.1 - 7.3e-07 29.5 0.1 7.9e-06 26.2 0.1 2.3 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain AdoMet_MTase PF07757.13 EMC81441.1 - 7.9e-41 138.9 0.1 1.6e-40 137.9 0.1 1.6 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase MetW PF07021.12 EMC81441.1 - 0.017 14.8 0.0 0.031 13.9 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_31 PF13847.6 EMC81441.1 - 0.039 13.7 0.0 0.13 12.1 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_32 PF13679.6 EMC81441.1 - 0.058 13.4 0.0 0.2 11.7 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 EMC81441.1 - 0.082 12.5 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain 7tm_1 PF00001.21 EMC81442.1 - 9.5e-35 120.2 19.4 1.1e-34 120.0 19.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC81442.1 - 0.0019 17.9 22.2 0.0044 16.7 21.0 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx PGG PF13962.6 EMC81442.1 - 5.4 6.9 9.3 0.12 12.2 0.7 2.5 2 1 1 3 3 3 0 Domain of unknown function Peptidase_M14 PF00246.24 EMC81443.1 - 2.2e-76 257.4 0.0 2.9e-76 257.0 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Fz PF01392.22 EMC81443.1 - 1.1e-21 77.5 2.8 2.4e-21 76.5 2.8 1.6 1 0 0 1 1 1 1 Fz domain CarboxypepD_reg PF13620.6 EMC81443.1 - 5e-15 55.5 0.0 9.7e-15 54.6 0.0 1.5 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 EMC81443.1 - 9.6e-07 28.7 0.0 1.7e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 CarboxypepD_reg-like domain AstE_AspA PF04952.14 EMC81443.1 - 0.0094 15.1 0.0 1.2 8.2 0.1 2.8 3 1 0 3 3 3 1 Succinylglutamate desuccinylase / Aspartoacylase family Glypican PF01153.19 EMC81443.1 - 0.0099 14.8 1.5 0.015 14.2 1.5 1.1 1 0 0 1 1 1 1 Glypican 7tm_1 PF00001.21 EMC81444.1 - 2e-75 253.5 5.5 2.7e-75 253.1 5.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC81444.1 - 1.1e-10 41.4 15.7 5.6e-08 32.5 5.0 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC81444.1 - 2.7e-07 30.6 9.3 1.7e-06 28.0 2.6 2.4 3 0 0 3 3 3 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC81444.1 - 1.1e-06 28.5 7.8 1.1e-06 28.5 7.8 2.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx FA_desaturase PF00487.24 EMC81444.1 - 0.016 15.0 0.0 0.016 15.0 0.0 2.6 2 2 1 3 3 3 0 Fatty acid desaturase DUF4614 PF15391.6 EMC81444.1 - 0.23 11.4 8.0 0.43 10.5 8.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) IL8 PF00048.20 EMC81445.1 - 1.3e-19 70.1 1.2 1.6e-19 69.8 1.2 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Alpha-2-MRAP_C PF06401.11 EMC81446.1 - 1.5e-72 244.0 29.3 1.5e-72 244.0 29.3 1.5 2 0 0 2 2 2 1 Alpha-2-macroglobulin RAP, C-terminal domain Alpha-2-MRAP_N PF06400.11 EMC81446.1 - 2.9e-27 95.0 29.0 3.6e-24 85.0 2.7 3.5 2 1 0 3 3 3 3 Alpha-2-macroglobulin RAP, N-terminal domain Spectrin PF00435.21 EMC81446.1 - 0.017 15.6 15.6 0.19 12.2 6.3 2.8 2 1 0 2 2 2 0 Spectrin repeat DUF5053 PF16476.5 EMC81446.1 - 0.41 10.4 3.5 5.2 6.8 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5053) Med30 PF11315.8 EMC81446.1 - 0.82 9.9 15.5 0.071 13.3 6.8 2.8 1 1 2 3 3 3 0 Mediator complex subunit 30 Trypsin PF00089.26 EMC81447.1 - 8.8e-74 248.0 0.3 9.9e-74 247.9 0.3 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 EMC81447.1 - 3.1e-06 27.5 0.3 6.6e-06 26.5 0.3 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 EMC81447.1 - 0.018 16.0 0.1 0.12 13.3 0.1 2.0 1 1 0 1 1 1 0 Trypsin-like peptidase domain fn2 PF00040.19 EMC81448.1 - 2.9e-15 56.3 6.9 6.7e-15 55.1 6.9 1.7 1 0 0 1 1 1 1 Fibronectin type II domain RGS12_us1 PF16613.5 EMC81449.1 - 3.5e-57 191.8 14.9 3.5e-57 191.8 14.9 3.2 3 0 0 3 3 3 1 Unstructured region of RGS12 RGS12_usC PF16612.5 EMC81449.1 - 1.1e-55 187.9 5.1 1.1e-55 187.9 5.1 3.0 3 1 0 3 3 3 1 C-terminal unstructured region of RGS12 RBD PF02196.15 EMC81449.1 - 4.5e-32 109.9 0.0 2.9e-20 72.1 0.0 2.6 2 0 0 2 2 2 2 Raf-like Ras-binding domain RGS12_us2 PF16611.5 EMC81449.1 - 3.3e-28 97.9 9.9 3.3e-28 97.9 9.9 3.1 3 0 0 3 3 2 1 Unstructured region between RBD and GoLoco RGS PF00615.19 EMC81449.1 - 6.6e-28 97.4 3.3 1.2e-27 96.5 3.3 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain PDZ PF00595.24 EMC81449.1 - 9.9e-14 51.5 0.1 1.4e-12 47.8 0.0 2.9 2 1 1 3 3 3 1 PDZ domain GoLoco PF02188.17 EMC81449.1 - 4.4e-09 35.6 0.3 1.1e-08 34.4 0.3 1.7 1 0 0 1 1 1 1 GoLoco motif PDZ_6 PF17820.1 EMC81449.1 - 2.5e-08 33.7 0.0 6.1e-08 32.4 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PID PF00640.23 EMC81449.1 - 0.00069 19.7 0.0 0.002 18.2 0.0 1.7 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PDZ_2 PF13180.6 EMC81449.1 - 0.00086 19.6 0.0 0.0034 17.7 0.0 2.0 1 0 0 1 1 1 1 PDZ domain TUG-UBL1 PF11470.8 EMC81449.1 - 0.0023 18.1 0.2 0.23 11.7 0.0 3.6 4 0 0 4 4 4 1 TUG ubiquitin-like domain PT-HINT PF07591.11 EMC81449.1 - 0.018 15.3 0.0 0.048 13.9 0.0 1.6 1 0 0 1 1 1 0 Pretoxin HINT domain Myb_DNA-bind_4 PF13837.6 EMC81450.1 - 3.9e-12 46.4 1.5 3.9e-12 46.4 1.5 2.3 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.9 EMC81450.1 - 0.0042 17.4 0.2 0.0042 17.4 0.2 2.4 2 1 1 3 3 3 1 Alcohol dehydrogenase transcription factor Myb/SANT-like DUF87 PF01935.17 EMC81450.1 - 0.56 10.3 4.5 1.2 9.2 2.2 2.0 1 1 1 2 2 2 0 Helicase HerA, central domain MCM_OB PF17207.3 EMC81450.1 - 0.69 9.8 4.3 4 7.3 0.1 2.4 2 1 0 2 2 2 0 MCM OB domain Myb_DNA-bind_3 PF12776.7 EMC81450.1 - 2.3 9.3 7.6 1.7 9.7 0.6 2.5 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Vac14_Fab1_bd PF12755.7 EMC81451.1 - 0.0069 17.0 0.1 0.0074 16.9 0.1 1.2 1 0 0 1 1 1 1 Vacuolar 14 Fab1-binding region VPS9 PF02204.18 EMC81451.1 - 0.073 13.3 0.1 0.094 12.9 0.1 1.1 1 0 0 1 1 1 0 Vacuolar sorting protein 9 (VPS9) domain HEAT PF02985.22 EMC81451.1 - 0.1 12.9 0.2 0.3 11.5 0.1 1.9 1 1 0 1 1 1 0 HEAT repeat Pkinase PF00069.25 EMC81452.1 - 4.2e-63 213.2 0.0 5.5e-63 212.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81452.1 - 1.1e-33 116.6 0.0 1.5e-33 116.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.19 EMC81452.1 - 6.3e-22 78.1 0.1 1.4e-21 76.9 0.1 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain Kinase-like PF14531.6 EMC81452.1 - 5.1e-05 22.7 0.0 8.2e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMC81452.1 - 0.00062 18.7 0.0 0.0013 17.5 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Nop14 PF04147.12 EMC81453.1 - 2.9e-265 882.8 39.0 3.6e-265 882.5 39.0 1.0 1 0 0 1 1 1 1 Nop14-like family DUF2810 PF10928.8 EMC81453.1 - 0.00034 20.5 0.4 0.079 13.0 0.0 3.4 3 0 0 3 3 3 1 Protein of unknown function (DUF2810) PAP_central PF04928.17 EMC81453.1 - 2.1 7.3 5.6 4.7 6.1 4.4 2.2 2 0 0 2 2 2 0 Poly(A) polymerase central domain RRN3 PF05327.11 EMC81453.1 - 2.9 6.3 31.1 1.8 7.0 17.5 2.5 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 Metal_resist PF13801.6 EMC81453.1 - 9.5 6.4 12.9 7.1 6.8 2.0 2.8 2 0 0 2 2 2 0 Heavy-metal resistance MFS_1 PF07690.16 EMC81454.1 - 6.8e-38 130.5 64.8 1.8e-35 122.5 38.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMC81454.1 - 8.5e-11 41.4 10.7 8.5e-11 41.4 10.7 2.3 2 2 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EMC81454.1 - 1.6e-05 23.6 3.9 1.6e-05 23.6 3.9 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Deltameth_res PF16020.5 EMC81454.1 - 0.31 10.9 1.4 0.86 9.5 0.0 2.5 2 0 0 2 2 2 0 Deltamethrin resistance NTS_2 PF15448.6 EMC81454.1 - 0.33 11.4 1.0 0.49 10.8 0.1 1.7 2 0 0 2 2 2 0 N-terminal segments of P. falciparum erythrocyte membrane protein Papilloma_E5 PF03025.14 EMC81454.1 - 5.9 7.1 12.2 3.9 7.7 0.8 3.7 4 0 0 4 4 4 0 Papillomavirus E5 Aldolase_II PF00596.21 EMC81455.1 - 6.4e-45 153.4 0.1 9.5e-45 152.8 0.1 1.3 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain PH PF00169.29 EMC81456.1 - 1.2e-19 70.7 0.5 3.1e-19 69.4 0.2 1.9 2 0 0 2 2 2 1 PH domain SH2 PF00017.24 EMC81456.1 - 1.4e-05 25.1 0.0 3.2e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 SH2 domain PH_6 PF15406.6 EMC81456.1 - 0.0075 16.5 0.0 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain EABR PF12180.8 EMC81457.1 - 9e-16 57.2 4.5 9e-16 57.2 4.5 2.4 2 0 0 2 2 2 1 TSG101 and ALIX binding domain of CEP55 CC2-LZ PF16516.5 EMC81457.1 - 2e-08 34.5 12.3 2e-08 34.5 12.3 5.4 1 1 3 5 5 5 2 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator FlxA PF14282.6 EMC81457.1 - 0.0024 17.8 6.6 0.0024 17.8 6.6 6.1 1 1 5 6 6 4 1 FlxA-like protein DUF1192 PF06698.11 EMC81457.1 - 0.031 14.3 16.0 0.29 11.2 0.3 5.6 4 2 1 5 5 5 0 Protein of unknown function (DUF1192) Cons_hypoth95 PF03602.15 EMC81457.1 - 0.042 13.5 0.7 0.14 11.8 0.7 1.9 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PRKG1_interact PF15898.5 EMC81457.1 - 0.2 12.5 0.2 0.2 12.5 0.2 5.7 2 1 2 4 4 3 0 cGMP-dependent protein kinase interacting domain HU-CCDC81_bac_2 PF18175.1 EMC81457.1 - 0.97 9.4 8.5 2.2 8.2 0.2 3.6 3 0 0 3 3 3 0 CCDC81-like prokaryotic HU domain 2 Golgin_A5 PF09787.9 EMC81457.1 - 1.1 8.6 54.7 0.33 10.4 16.7 2.5 1 1 1 2 2 2 0 Golgin subfamily A member 5 APG6_N PF17675.1 EMC81457.1 - 1.2 9.6 60.8 5.4 7.6 15.9 3.5 1 1 2 3 3 3 0 Apg6 coiled-coil region 3-PAP PF12578.8 EMC81457.1 - 2.8 7.7 17.9 1.3 8.8 1.0 4.9 5 1 0 5 5 5 0 Myotubularin-associated protein MAD PF05557.13 EMC81457.1 - 4 5.7 55.8 0.13 10.6 21.7 2.7 1 1 1 2 2 2 0 Mitotic checkpoint protein FAM193_C PF15914.5 EMC81458.1 - 5.7e-31 106.0 0.9 1.4e-30 104.8 0.9 1.7 1 0 0 1 1 1 1 FAM193 family C-terminal Sec34 PF04136.15 EMC81458.1 - 0.0039 17.1 0.9 0.0039 17.1 0.9 3.2 3 0 0 3 3 3 1 Sec34-like family Desmo_N PF06771.11 EMC81458.1 - 0.058 13.8 0.9 0.43 11.0 0.4 2.3 2 0 0 2 2 2 0 Viral Desmoplakin N-terminus zf-C3HC4_2 PF13923.6 EMC81459.1 - 3.7e-11 42.7 7.2 1.2e-10 41.1 7.2 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC81459.1 - 5.7e-11 42.6 6.2 1.2e-10 41.6 6.2 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EMC81459.1 - 1.5e-10 40.9 3.9 3.7e-10 39.7 3.9 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EMC81459.1 - 1.4e-09 37.6 5.8 2.7e-09 36.7 5.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC81459.1 - 4.7e-09 36.1 6.3 9.1e-09 35.1 6.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EMC81459.1 - 6.1e-09 35.6 6.0 1.4e-08 34.5 6.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC81459.1 - 5.3e-07 29.4 11.3 6.9e-07 29.0 4.2 2.4 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 EMC81459.1 - 3.9e-06 26.5 2.9 9.7e-06 25.3 2.9 1.7 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 EMC81459.1 - 7.6e-05 22.9 8.0 0.00047 20.4 8.1 2.1 1 1 1 2 2 2 1 RING-H2 zinc finger domain zf-UDP PF14569.6 EMC81459.1 - 0.00067 19.7 4.1 0.0037 17.3 2.4 2.2 2 0 0 2 2 2 1 Zinc-binding RING-finger zf-C3HC4_4 PF15227.6 EMC81459.1 - 0.0011 19.1 10.1 0.027 14.6 10.2 2.7 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 EMC81459.1 - 0.0063 16.1 3.8 0.012 15.2 3.8 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 EMC81459.1 - 0.0082 15.9 1.9 0.023 14.4 1.9 1.8 1 1 0 1 1 1 1 RING-like zinc finger Rtf2 PF04641.12 EMC81459.1 - 0.014 14.8 6.6 0.044 13.2 6.6 2.1 1 1 0 1 1 1 0 Rtf2 RING-finger zf-P11 PF03854.14 EMC81459.1 - 0.027 14.1 2.4 0.027 14.1 2.4 2.1 2 0 0 2 2 2 0 P-11 zinc finger zinc-ribbons_6 PF07191.12 EMC81459.1 - 0.029 14.3 5.0 0.076 13.0 5.0 1.7 1 1 0 1 1 1 0 zinc-ribbons zf-RING_10 PF16685.5 EMC81459.1 - 0.034 14.3 7.8 0.084 13.0 7.8 1.7 1 1 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_6 PF14835.6 EMC81459.1 - 0.06 13.2 5.7 0.24 11.3 5.7 2.0 1 1 0 1 1 1 0 zf-RING of BARD1-type protein DUF1272 PF06906.11 EMC81459.1 - 0.15 12.1 5.6 0.36 10.9 5.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1272) zf-ANAPC11 PF12861.7 EMC81459.1 - 0.25 11.4 3.6 0.5 10.4 3.6 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger IBR PF01485.21 EMC81459.1 - 0.25 11.6 6.6 1.5 9.1 6.6 2.2 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain FANCL_C PF11793.8 EMC81459.1 - 0.28 11.4 5.6 6.8 7.0 5.6 2.6 1 1 0 1 1 1 0 FANCL C-terminal domain DZR PF12773.7 EMC81459.1 - 0.35 10.9 6.6 0.18 11.9 2.5 2.0 1 1 0 1 1 1 0 Double zinc ribbon zf-Nse PF11789.8 EMC81459.1 - 0.99 9.3 7.2 1.9 8.4 5.7 2.3 2 1 0 2 2 1 0 Zinc-finger of the MIZ type in Nse subunit FYVE PF01363.21 EMC81459.1 - 1.2 9.3 9.6 8.3 6.6 8.0 2.5 1 1 1 2 2 2 0 FYVE zinc finger Zn-ribbon_8 PF09723.10 EMC81459.1 - 1.5 9.0 6.9 3.8 7.7 2.6 2.6 2 0 0 2 2 2 0 Zinc ribbon domain Prim_Zn_Ribbon PF08273.12 EMC81459.1 - 2.2 8.6 5.2 0.87 9.9 1.2 2.2 2 1 0 2 2 2 0 Zinc-binding domain of primase-helicase FYVE PF01363.21 EMC81460.1 - 3.6e-19 68.7 11.9 3.6e-19 68.7 11.9 2.9 3 1 0 3 3 3 1 FYVE zinc finger DUF4668 PF15701.5 EMC81460.1 - 3.3 7.5 4.7 7.5 6.3 4.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4668) Cwf_Cwc_15 PF04889.12 EMC81460.1 - 9 5.9 17.2 1.6 8.4 12.7 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein HLH PF00010.26 EMC81461.1 - 6.6e-12 45.2 3.0 4.7e-11 42.5 3.4 2.2 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Myc-LZ PF02344.15 EMC81461.1 - 0.0025 17.9 8.0 0.0025 17.9 8.0 2.5 2 0 0 2 2 2 1 Myc leucine zipper domain Striatin PF08232.12 EMC81461.1 - 0.014 16.0 5.6 0.19 12.3 1.0 2.1 2 0 0 2 2 2 0 Striatin family UPF0449 PF15136.6 EMC81461.1 - 0.93 10.0 6.5 0.6 10.6 2.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 Tugs PF17840.1 EMC81461.1 - 2.2 8.5 9.7 0.12 12.5 3.5 2.0 2 0 0 2 2 2 0 Tethering Ubl4a to BAGS domain HAUS-augmin3 PF14932.6 EMC81462.1 - 3.4e-78 262.8 26.7 3.4e-78 262.8 26.7 3.9 3 1 1 4 4 4 1 HAUS augmin-like complex subunit 3 Baculo_PEP_C PF04513.12 EMC81462.1 - 0.0093 16.0 31.2 0.093 12.8 5.6 4.7 4 1 0 4 4 4 3 Baculovirus polyhedron envelope protein, PEP, C terminus DUF769 PF05590.11 EMC81462.1 - 0.038 13.4 0.1 0.095 12.1 0.0 1.7 2 0 0 2 2 2 0 Xylella fastidiosa protein of unknown function (DUF769) WD40_alt PF14077.6 EMC81462.1 - 0.093 12.6 10.0 0.21 11.4 0.0 4.3 5 0 0 5 5 5 0 Alternative WD40 repeat motif DNA_pol_A PF00476.20 EMC81463.1 - 6.2e-125 417.2 4.1 7.8e-125 416.8 4.1 1.1 1 0 0 1 1 1 1 DNA polymerase family A DNA_pol_P_Exo PF18049.1 EMC81463.1 - 9e-94 312.8 1.5 2.1e-93 311.6 1.5 1.7 1 0 0 1 1 1 1 DNA polymerase nu pseudo-exo Acetyltransf_1 PF00583.25 EMC81464.1 - 1.2e-14 54.5 0.1 1.6e-14 54.1 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EMC81464.1 - 3.8e-13 49.7 0.0 5.5e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EMC81464.1 - 2.4e-12 46.9 0.1 4.2e-12 46.1 0.1 1.4 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EMC81464.1 - 2.7e-07 30.6 0.0 1.1e-05 25.5 0.0 2.0 1 1 1 2 2 2 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 EMC81464.1 - 5.5e-05 23.9 0.1 7.4e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EMC81464.1 - 9.7e-05 21.9 0.1 0.00072 19.1 0.1 2.0 1 1 0 1 1 1 1 Putative acetyl-transferase FR47 PF08445.10 EMC81464.1 - 0.00091 19.2 1.2 0.0023 17.9 0.1 1.9 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_8 PF13523.6 EMC81464.1 - 0.0016 18.2 0.0 0.002 17.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EMC81464.1 - 0.002 18.2 0.2 0.02 15.0 0.0 2.1 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EMC81464.1 - 0.012 15.7 0.0 0.017 15.3 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 EMC81464.1 - 0.11 12.0 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase Neuropep_like PF15161.6 EMC81465.1 - 5.4e-29 99.7 0.3 8.5e-29 99.0 0.3 1.3 1 0 0 1 1 1 1 Neuropeptide-like LETM1 PF07766.13 EMC81467.1 - 1.1e-88 297.1 12.7 1.1e-88 297.1 12.7 4.1 2 2 2 4 4 4 1 LETM1-like protein EF-hand_1 PF00036.32 EMC81467.1 - 0.014 14.9 0.3 0.21 11.2 0.1 2.7 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.6 EMC81467.1 - 0.025 14.5 0.2 0.79 9.8 0.1 2.9 2 0 0 2 2 2 0 EF-hand domain Acetyltransf_11 PF13720.6 EMC81467.1 - 0.13 12.8 1.8 0.35 11.4 0.4 2.7 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 TolA_bind_tri PF16331.5 EMC81467.1 - 0.23 11.6 6.4 1.6 8.9 3.6 3.0 1 1 1 2 2 2 0 TolA binding protein trimerisation EF-hand_7 PF13499.6 EMC81467.1 - 0.37 11.3 0.1 0.37 11.3 0.1 2.7 3 0 0 3 3 3 0 EF-hand domain pair Pkinase_Tyr PF07714.17 EMC81468.1 - 4.7e-105 350.5 0.0 6.3e-105 350.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC81468.1 - 7.5e-45 153.4 0.0 1e-44 152.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.16 EMC81468.1 - 6.4e-38 128.7 0.0 5.5e-14 52.0 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC81468.1 - 1.3e-36 125.0 0.1 1.8e-12 47.7 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 EMC81468.1 - 4.1e-27 94.3 0.1 5.7e-10 39.4 0.0 3.7 3 1 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 EMC81468.1 - 4e-25 87.8 0.2 6.7e-08 32.6 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain FGFR3_TM PF18123.1 EMC81468.1 - 2.9e-15 55.5 8.2 4.9e-15 54.8 8.2 1.4 1 0 0 1 1 1 1 Fibroblast growth factor receptor 3 transmembrane domain V-set PF07686.17 EMC81468.1 - 9.1e-15 54.8 8.3 5.7e-05 23.2 0.1 5.7 4 3 1 5 5 5 3 Immunoglobulin V-set domain Ig_5 PF16681.5 EMC81468.1 - 1.4e-09 38.2 0.0 0.072 13.5 0.0 4.1 3 1 0 3 3 3 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 EMC81468.1 - 7.8e-08 32.5 0.0 0.00062 20.0 0.0 3.8 3 1 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 EMC81468.1 - 4.5e-06 26.1 0.0 0.7 9.5 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 EMC81468.1 - 0.00041 20.3 0.1 0.052 13.6 0.0 3.2 3 1 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 EMC81468.1 - 0.0064 16.5 0.0 19 5.4 0.0 3.5 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain V-set_CD47 PF08204.11 EMC81468.1 - 0.008 16.2 0.1 1 9.4 0.0 3.2 3 0 0 3 3 3 1 CD47 immunoglobulin-like domain Shisa PF13908.6 EMC81468.1 - 0.012 15.9 0.0 0.021 15.1 0.0 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator INCENP_ARK-bind PF03941.15 EMC81468.1 - 0.048 13.6 0.2 0.19 11.7 0.6 1.7 2 0 0 2 2 1 0 Inner centromere protein, ARK binding region Orthoreo_P10 PF07204.11 EMC81468.1 - 0.11 12.4 0.0 0.38 10.7 0.0 1.8 2 0 0 2 2 2 0 Orthoreovirus membrane fusion protein p10 Pkinase_fungal PF17667.1 EMC81468.1 - 0.18 10.5 0.0 0.3 9.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Tex_N PF09371.10 EMC81469.1 - 3.3e-48 163.8 0.3 5.4e-48 163.1 0.3 1.3 1 0 0 1 1 1 1 Tex-like protein N-terminal domain Tex_YqgF PF16921.5 EMC81469.1 - 4.6e-38 130.5 0.0 1.1e-37 129.2 0.0 1.7 1 0 0 1 1 1 1 Tex protein YqgF-like domain RuvX PF03652.15 EMC81469.1 - 0.017 15.5 0.0 0.057 13.8 0.0 1.9 1 0 0 1 1 1 0 Holliday junction resolvase C2 PF00168.30 EMC81470.1 - 2.1e-15 56.9 0.0 2.3e-15 56.8 0.0 1.0 1 0 0 1 1 1 1 C2 domain Pkinase PF00069.25 EMC81471.1 - 1.4e-65 221.3 0.0 2.3e-65 220.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81471.1 - 9.9e-38 129.9 0.0 1.7e-37 129.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 EMC81471.1 - 3.8e-33 113.2 22.9 6.7e-17 61.1 5.4 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 EMC81471.1 - 7.2e-10 39.4 0.1 1.6e-09 38.3 0.1 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain FTA2 PF13095.6 EMC81471.1 - 0.0012 18.5 0.1 0.2 11.3 0.0 2.5 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 EMC81471.1 - 0.0055 16.0 0.0 0.0095 15.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC81471.1 - 0.022 14.1 0.0 0.039 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EMC81471.1 - 0.086 11.8 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain C1_2 PF03107.16 EMC81471.1 - 0.089 13.1 17.4 0.68 10.3 3.2 2.7 2 0 0 2 2 2 0 C1 domain APH PF01636.23 EMC81471.1 - 0.11 12.4 0.1 0.33 10.8 0.1 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Zf_RING PF16744.5 EMC81471.1 - 0.44 10.7 14.3 1.5 9.0 5.0 2.5 2 0 0 2 2 2 0 KIAA1045 RING finger PHD PF00628.29 EMC81471.1 - 8.9 6.3 21.4 1.7 8.6 4.9 2.6 2 0 0 2 2 2 0 PHD-finger PAS_3 PF08447.12 EMC81472.1 - 2.4e-27 95.0 0.0 1.4e-20 73.4 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 EMC81472.1 - 2.3e-22 79.2 0.2 5.1e-19 68.5 0.1 2.5 2 0 0 2 2 2 2 PAS domain HIF-1a_CTAD PF08778.10 EMC81472.1 - 2.7e-19 68.5 1.0 7.5e-19 67.1 1.0 1.8 1 0 0 1 1 1 1 HIF-1 alpha C terminal transactivation domain HIF-1 PF11413.8 EMC81472.1 - 2.1e-18 65.4 2.5 2.1e-17 62.2 2.1 2.4 2 0 0 2 2 2 1 Hypoxia-inducible factor-1 PAS PF00989.25 EMC81472.1 - 4.1e-14 52.5 0.0 3.1e-06 27.2 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 EMC81472.1 - 2.4e-08 34.1 0.0 0.0076 16.5 0.0 2.4 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 EMC81472.1 - 4.6e-07 30.1 0.0 0.039 14.2 0.0 2.4 2 0 0 2 2 2 2 PAS fold HLH PF00010.26 EMC81472.1 - 0.078 12.9 0.4 0.14 12.1 0.4 1.5 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain Corona_I PF03187.14 EMC81472.1 - 0.13 11.9 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 Corona nucleocapsid I protein Ras PF00071.22 EMC81473.1 - 5.6e-27 94.3 0.0 6.5e-27 94.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC81473.1 - 7.4e-05 23.0 0.0 0.00011 22.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PIG-F PF06699.11 EMC81474.1 - 2.7e-44 151.5 12.5 3.3e-44 151.2 12.5 1.1 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F Cript PF10235.9 EMC81475.1 - 2.6e-35 120.9 6.2 3e-35 120.7 6.2 1.0 1 0 0 1 1 1 1 Microtubule-associated protein CRIPT DUF2039 PF10217.9 EMC81475.1 - 0.011 16.0 6.6 0.015 15.6 6.6 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) zinc_ribbon_2 PF13240.6 EMC81475.1 - 0.13 12.0 6.0 1.1 9.1 0.1 2.7 2 1 0 2 2 2 0 zinc-ribbon domain Cas_CXXC_CXXC PF09706.10 EMC81475.1 - 0.21 11.8 7.9 1.5 9.1 0.2 2.8 1 1 2 3 3 3 0 CRISPR-associated protein (Cas_CXXC_CXXC) zf-H2C2_2 PF13465.6 EMC81476.1 - 8.1e-16 57.7 21.3 1.6e-08 34.6 1.9 4.4 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 EMC81476.1 - 3.9e-15 55.4 17.9 3.1e-05 24.2 0.5 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type DUF3446 PF11928.8 EMC81476.1 - 4.2e-12 46.2 3.7 1e-11 45.0 3.7 1.7 1 0 0 1 1 1 1 Early growth response N-terminal domain zf-C2H2_4 PF13894.6 EMC81476.1 - 6.7e-11 42.1 15.1 0.00097 19.8 2.4 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2HC_2 PF13913.6 EMC81476.1 - 0.00021 21.1 9.8 0.13 12.2 1.1 3.4 3 0 0 3 3 3 3 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.8 EMC81476.1 - 0.0022 18.2 2.7 8.2 6.8 0.2 3.5 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 EMC81476.1 - 0.003 17.5 9.3 0.057 13.4 5.1 2.9 1 1 2 3 3 3 1 BED zinc finger Zf_RING PF16744.5 EMC81476.1 - 0.076 13.1 1.4 0.72 10.0 0.1 2.2 1 1 1 2 2 2 0 KIAA1045 RING finger zf-H2C2_5 PF13909.6 EMC81476.1 - 0.1 12.4 0.1 0.1 12.4 0.1 3.3 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.6 EMC81476.1 - 0.15 12.1 8.6 0.46 10.5 0.6 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 EMC81476.1 - 0.2 12.3 2.7 2.4 8.9 0.6 2.6 1 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-met PF12874.7 EMC81476.1 - 0.22 12.0 4.3 21 5.7 0.6 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 EMC81476.1 - 0.76 9.6 9.1 16 5.3 0.1 3.4 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 EMC81476.1 - 4.5 7.7 6.9 38 4.7 6.9 2.2 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) PDZ PF00595.24 EMC81477.1 - 1.1e-15 57.7 0.1 1.8e-15 57.1 0.1 1.3 1 0 0 1 1 1 1 PDZ domain DUF4749 PF15936.5 EMC81477.1 - 5.8e-10 40.2 0.1 1.8e-09 38.6 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4749) PDZ_6 PF17820.1 EMC81477.1 - 6.7e-08 32.3 0.2 1.3e-07 31.3 0.2 1.5 1 0 0 1 1 1 1 PDZ domain LIM PF00412.22 EMC81477.1 - 1.3e-05 25.3 2.3 2e-05 24.7 2.3 1.3 1 0 0 1 1 1 1 LIM domain PDZ_2 PF13180.6 EMC81477.1 - 2.1e-05 24.8 0.0 3.6e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 PDZ domain zf_UBZ PF18439.1 EMC81477.1 - 1 9.0 3.3 21 4.8 0.1 3.1 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger SH3_1 PF00018.28 EMC81478.1 - 4.2e-16 58.3 0.1 4.4e-13 48.6 0.0 2.3 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 EMC81478.1 - 1.1e-14 53.8 0.1 2.1e-14 52.9 0.0 1.5 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 EMC81478.1 - 5e-14 51.9 0.1 5.2e-13 48.6 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain Metallophos PF00149.28 EMC81479.1 - 6.6e-37 128.0 0.0 1.1e-36 127.3 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF5378 PF17349.2 EMC81479.1 - 0.0013 18.2 0.0 0.002 17.5 0.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5378) Zip PF02535.22 EMC81481.1 - 5.5e-36 124.4 1.0 6.3e-36 124.2 1.0 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter RNA_pol_Rpc4 PF05132.14 EMC81482.1 - 4.8e-31 108.2 3.5 6.4e-31 107.8 0.4 2.5 2 0 0 2 2 2 1 RNA polymerase III RPC4 fn3 PF00041.21 EMC81483.1 - 4.7e-05 23.7 0.1 0.00032 21.0 0.0 2.3 2 1 0 2 2 2 1 Fibronectin type III domain EPTP PF03736.17 EMC81484.1 - 1.3e-66 220.3 11.3 7.6e-12 45.0 0.1 7.5 7 0 0 7 7 7 7 EPTP domain LRR_8 PF13855.6 EMC81484.1 - 1.4e-21 76.0 12.8 1.2e-13 50.6 5.9 2.5 1 1 1 2 2 2 2 Leucine rich repeat LRR_5 PF13306.6 EMC81484.1 - 1.6e-07 31.4 0.0 3.2e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 EMC81484.1 - 1.3e-06 28.6 10.2 0.0016 18.8 1.0 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC81484.1 - 1.8e-05 24.3 0.2 3.2e-05 23.5 0.2 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRRCT PF01463.24 EMC81484.1 - 0.00049 20.4 0.1 0.0031 17.9 0.1 2.4 2 0 0 2 2 2 1 Leucine rich repeat C-terminal domain DUF2671 PF10877.8 EMC81484.1 - 0.022 14.5 0.1 0.87 9.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2671) LRR_1 PF00560.33 EMC81484.1 - 0.32 11.7 8.4 8.3 7.4 0.5 4.5 4 0 0 4 4 4 0 Leucine Rich Repeat TPKR_C2 PF16920.5 EMC81484.1 - 0.35 11.0 2.0 4 7.7 0.4 3.1 2 0 0 2 2 2 0 Tyrosine-protein kinase receptor C2 Ig-like domain RCDG1 PF15725.5 EMC81484.1 - 0.8 10.2 3.0 3.5 8.1 1.5 2.4 2 0 0 2 2 2 0 Renal cancer differentiation gene 1 protein RAI16-like PF10257.9 EMC81485.1 - 3.3e-93 312.4 0.0 4.2e-93 312.1 0.0 1.1 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein PH PF00169.29 EMC81487.1 - 1.7e-05 25.2 0.0 1.9e-05 25.1 0.0 1.1 1 0 0 1 1 1 1 PH domain Sharpin_PH PF16764.5 EMC81487.1 - 0.052 13.3 0.0 0.061 13.1 0.0 1.1 1 0 0 1 1 1 0 Sharpin PH domain DUF5628 PF18621.1 EMC81487.1 - 0.096 13.2 0.0 0.11 12.9 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5628) FGF PF00167.18 EMC81489.1 - 4.8e-41 139.8 1.0 6.6e-41 139.3 1.0 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.13 EMC81489.1 - 0.041 14.1 0.1 0.063 13.5 0.1 1.4 1 0 0 1 1 1 0 Fascin domain TLP1_add_C PF18313.1 EMC81489.1 - 0.054 13.4 0.5 5.8 6.9 0.0 2.3 2 0 0 2 2 2 0 Thiolase-like protein type 1 additional C-terminal domain IL1 PF00340.19 EMC81489.1 - 0.099 12.3 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Interleukin-1 / 18 Polysacc_synt_4 PF04669.13 EMC81490.1 - 4.5e-22 78.5 0.3 1.8e-20 73.3 0.3 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis CRM1_C PF08767.11 EMC81491.1 - 0.0096 15.1 1.2 0.015 14.5 1.2 1.6 1 1 0 1 1 1 1 CRM1 C terminal XPC-binding PF09280.11 EMC81491.1 - 1.9 8.3 6.2 5.7 6.8 1.6 3.4 4 1 0 4 4 4 0 XPC-binding domain IRS PF02174.17 EMC81492.1 - 1.6e-30 105.0 0.2 2.9e-30 104.1 0.2 1.4 1 0 0 1 1 1 1 PTB domain (IRS-1 type) PH PF00169.29 EMC81492.1 - 0.001 19.5 0.0 0.0024 18.4 0.0 1.6 1 0 0 1 1 1 1 PH domain GDNF PF02351.16 EMC81494.1 - 2.3e-18 66.9 2.8 2.7e-18 66.7 0.5 1.9 2 0 0 2 2 2 1 GDNF/GAS1 domain Fez1 PF06818.15 EMC81495.1 - 6.3e-69 232.4 59.2 2.7e-66 223.8 31.5 2.2 2 0 0 2 2 2 2 Fez1 Atg14 PF10186.9 EMC81495.1 - 0.0016 17.6 13.3 0.0016 17.6 13.3 4.0 2 1 2 4 4 4 2 Vacuolar sorting 38 and autophagy-related subunit 14 PKcGMP_CC PF16808.5 EMC81495.1 - 0.016 15.1 14.3 0.036 13.9 0.7 5.4 3 2 1 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Spc7 PF08317.11 EMC81495.1 - 0.051 12.4 60.3 0.084 11.7 19.4 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 EMC81495.1 - 0.35 10.9 75.1 0.42 10.6 16.1 4.0 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MAD PF05557.13 EMC81495.1 - 0.92 7.8 62.8 0.39 9.0 41.2 3.2 1 1 1 3 3 3 0 Mitotic checkpoint protein FPP PF05911.11 EMC81495.1 - 2 6.5 60.8 3.5 5.7 17.9 2.1 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil DUF3584 PF12128.8 EMC81495.1 - 5.5 4.4 54.1 19 2.6 54.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) ATP-synt_ab PF00006.25 EMC81496.1 - 2.7e-68 229.8 0.0 3.9e-68 229.3 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EMC81496.1 - 2.4e-13 50.4 0.4 5.8e-13 49.2 0.1 1.8 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain DUF2481 PF10654.9 EMC81496.1 - 0.15 12.0 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2481) MFS_1 PF07690.16 EMC81497.1 - 3.4e-40 138.1 48.5 7.9e-33 113.8 37.7 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily LacY_symp PF01306.19 EMC81497.1 - 0.5 9.1 15.8 0.47 9.2 3.8 2.3 2 0 0 2 2 2 0 LacY proton/sugar symporter CPP1-like PF11833.8 EMC81497.1 - 2.2 7.9 5.2 5.7 6.6 5.2 1.7 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF2070 PF09843.9 EMC81497.1 - 4.4 5.5 10.0 2.4 6.3 7.5 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2070) zf-RING_2 PF13639.6 EMC81498.1 - 2.3e-12 47.0 8.8 5.2e-12 45.9 8.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EMC81498.1 - 3.9e-11 42.5 1.8 1.1e-10 41.0 1.8 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 EMC81498.1 - 6.6e-08 32.3 7.8 1.6e-07 31.0 7.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC81498.1 - 8.9e-08 32.0 3.1 9.5e-08 31.9 1.5 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 EMC81498.1 - 1.7e-07 31.4 11.0 1.2e-06 28.7 11.0 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EMC81498.1 - 2.2e-07 30.6 9.4 4.8e-07 29.5 9.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC81498.1 - 1.6e-05 24.7 7.3 3.1e-05 23.8 7.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EMC81498.1 - 2.2e-05 24.2 7.2 5.3e-05 23.0 7.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EMC81498.1 - 0.00043 20.3 6.3 0.0011 19.0 6.3 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EMC81498.1 - 0.0046 16.8 7.0 0.009 15.9 7.0 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Prok-RING_1 PF14446.6 EMC81498.1 - 0.12 12.3 8.2 0.14 12.1 2.8 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 zf-C3H2C3 PF17122.5 EMC81498.1 - 0.29 11.2 6.6 0.88 9.7 6.6 1.9 1 1 0 1 1 1 0 Zinc-finger FANCL_C PF11793.8 EMC81498.1 - 0.4 10.9 9.6 16 5.7 9.6 2.7 1 1 0 1 1 1 0 FANCL C-terminal domain UPA PF17217.3 EMC81499.1 - 8.8e-42 142.3 0.7 2.2e-41 141.0 0.0 2.1 2 1 0 2 2 2 1 UPA domain ZU5 PF00791.20 EMC81499.1 - 1.4e-28 99.1 0.0 3.1e-28 98.0 0.0 1.6 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 EMC81499.1 - 2.5e-13 50.0 0.1 5.2e-13 49.0 0.1 1.5 1 0 0 1 1 1 1 Death domain I-set PF07679.16 EMC81499.1 - 2.7e-12 46.6 0.0 1.9e-11 43.9 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC81499.1 - 2.7e-12 47.1 0.0 5.2e-10 39.8 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin domain TSP_1 PF00090.19 EMC81499.1 - 2.7e-11 43.5 25.2 4e-07 30.1 10.6 3.3 2 0 0 2 2 2 2 Thrombospondin type 1 domain ig PF00047.25 EMC81499.1 - 1.9e-08 34.3 0.0 9.7e-08 32.1 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 EMC81499.1 - 9.8e-08 32.2 0.0 3.4e-07 30.5 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain Ig_6 PF18452.1 EMC81499.1 - 0.018 14.6 0.0 0.046 13.3 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 EMC81499.1 - 0.029 14.5 0.0 0.21 11.8 0.0 2.3 1 1 0 1 1 1 0 Immunoglobulin V-set domain DUF4573 PF15140.6 EMC81500.1 - 4.4e-09 36.4 13.4 1.2e-05 25.2 7.3 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF4573) zf-C2H2 PF00096.26 EMC81501.1 - 0.041 14.4 0.3 0.041 14.4 0.3 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf_ZIC PF18366.1 EMC81501.1 - 0.041 14.0 0.1 0.13 12.4 0.1 1.8 1 0 0 1 1 1 0 Zic proteins zinc finger domain zf-C2H2_4 PF13894.6 EMC81501.1 - 0.14 13.0 0.3 0.14 13.0 0.3 2.7 3 0 0 3 3 3 0 C2H2-type zinc finger Band_7 PF01145.25 EMC81502.1 - 2.8e-16 60.0 0.2 2.8e-16 60.0 0.2 1.7 2 0 0 2 2 2 1 SPFH domain / Band 7 family DUF4346 PF14251.6 EMC81502.1 - 0.035 14.1 1.4 0.074 13.1 1.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4346) RBD-FIP PF09457.10 EMC81503.1 - 6.4e-17 61.2 2.1 1.4e-16 60.1 2.1 1.6 1 0 0 1 1 1 1 FIP domain NUP50 PF08911.11 EMC81503.1 - 0.026 15.2 0.2 0.026 15.2 0.2 3.6 5 0 0 5 5 5 0 NUP50 (Nucleoporin 50 kDa) 7tm_1 PF00001.21 EMC81504.1 - 1.5e-74 250.7 7.5 2.2e-74 250.1 7.5 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC81504.1 - 3.2e-13 49.7 9.7 2.2e-08 33.8 3.9 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC81504.1 - 4.2e-11 43.1 5.2 2.9e-10 40.4 1.1 2.1 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC81504.1 - 1.6e-06 27.9 4.6 1.6e-06 27.9 4.6 2.5 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx eIF_4EBP PF05456.11 EMC81505.1 - 6.1e-25 87.4 0.1 6.7e-25 87.3 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) TGF_beta PF00019.20 EMC81506.1 - 8.1e-30 103.9 1.5 1.8e-29 102.7 1.2 1.7 2 0 0 2 2 2 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 EMC81506.1 - 1.2e-06 28.4 0.0 2.6e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 TGF-beta propeptide SPRY PF00622.28 EMC81507.1 - 5.1e-12 46.0 0.2 8.2e-05 22.7 0.0 2.6 2 0 0 2 2 2 2 SPRY domain PHD20L1_u1 PF16660.5 EMC81507.1 - 0.063 14.0 2.4 0.11 13.2 2.4 1.3 1 0 0 1 1 1 0 PHD finger protein 20-like protein 1 START PF01852.19 EMC81508.1 - 3.3e-46 157.3 0.0 3.9e-46 157.1 0.0 1.1 1 0 0 1 1 1 1 START domain Polyketide_cyc PF03364.20 EMC81508.1 - 0.0089 16.2 0.0 0.025 14.8 0.0 1.8 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 EMC81508.1 - 0.083 13.2 0.0 1.7 8.9 0.0 2.8 2 2 0 2 2 2 0 Polyketide cyclase / dehydrase and lipid transport Pkinase PF00069.25 EMC81510.1 - 7.4e-62 209.1 0.0 1.5e-61 208.1 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81510.1 - 5.4e-35 120.9 0.0 7.3e-35 120.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.19 EMC81510.1 - 7.6e-19 68.1 0.0 1.7e-18 67.0 0.0 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain Kinase-like PF14531.6 EMC81510.1 - 0.00017 21.0 0.0 0.00029 20.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMC81510.1 - 0.00027 19.8 0.0 0.00054 18.8 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase LSM PF01423.22 EMC81511.1 - 0.00042 19.9 0.0 0.00083 19.0 0.0 1.5 1 0 0 1 1 1 1 LSM domain DDHD PF02862.17 EMC81512.1 - 1e-51 176.2 0.0 1.6e-51 175.6 0.0 1.3 1 0 0 1 1 1 1 DDHD domain SAM_1 PF00536.30 EMC81512.1 - 4.6e-12 46.2 0.0 8.4e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) WWE PF02825.20 EMC81512.1 - 1.4e-05 25.6 1.2 0.0022 18.5 0.5 2.7 2 0 0 2 2 2 1 WWE domain SAM_2 PF07647.17 EMC81512.1 - 0.0012 18.9 0.0 0.0022 18.1 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) IGR PF09597.10 EMC81512.1 - 0.066 13.3 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 IGR protein motif Phage_gp53 PF11246.8 EMC81512.1 - 0.15 11.7 0.2 0.26 10.9 0.2 1.3 1 0 0 1 1 1 0 Base plate wedge protein 53 PAP2 PF01569.21 EMC81513.1 - 1.8e-15 56.9 0.5 4e-15 55.8 0.1 1.7 2 0 0 2 2 2 1 PAP2 superfamily PWWP PF00855.17 EMC81514.1 - 3.8e-33 113.8 17.2 1.7e-20 73.2 1.7 4.0 3 1 0 3 3 3 2 PWWP domain C5HCH PF17982.1 EMC81514.1 - 1.3e-24 86.0 11.3 1.3e-24 86.0 11.3 4.5 4 0 0 4 4 4 1 NSD Cys-His rich domain SET PF00856.28 EMC81514.1 - 1.3e-19 71.3 0.4 1.3e-19 71.3 0.4 4.5 4 3 1 5 5 5 1 SET domain AWS PF17907.1 EMC81514.1 - 8.1e-17 61.0 8.5 8.1e-17 61.0 8.5 3.1 3 0 0 3 3 3 1 AWS domain PHD PF00628.29 EMC81514.1 - 7.1e-11 41.8 69.0 5.8e-05 22.9 8.6 6.5 4 2 2 6 6 6 4 PHD-finger zf-HC5HC2H_2 PF13832.6 EMC81514.1 - 0.0017 18.5 5.5 0.0017 18.5 5.5 6.1 3 2 2 5 5 5 2 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EMC81514.1 - 0.76 10.1 65.6 0.014 15.6 13.5 6.3 3 2 2 5 5 5 0 PHD-like zinc-binding domain PH PF00169.29 EMC81517.1 - 7.8e-28 97.1 0.1 3.7e-15 56.3 0.1 2.3 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 EMC81517.1 - 2.5e-10 40.7 0.4 1.2e-05 25.6 0.3 3.3 2 2 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 EMC81517.1 - 1.5e-09 38.0 1.0 0.0019 18.4 0.1 3.3 2 2 0 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.6 EMC81517.1 - 6.1e-09 36.3 0.2 0.0055 17.1 0.0 2.7 2 1 0 2 2 2 2 Pleckstrin homology domain Mcp5_PH PF12814.7 EMC81517.1 - 3e-05 24.1 0.0 0.00055 20.0 0.0 2.1 2 0 0 2 2 2 1 Meiotic cell cortex C-terminal pleckstrin homology PH_13 PF16652.5 EMC81517.1 - 0.0025 17.7 0.1 2 8.2 0.0 2.2 2 0 0 2 2 2 2 Pleckstrin homology domain PH_17 PF18012.1 EMC81517.1 - 0.16 11.7 0.4 1.6 8.5 0.1 2.4 2 1 0 2 2 2 0 PH domain Reprolysin PF01421.19 EMC81518.1 - 1.7e-67 227.2 0.1 3.3e-67 226.3 0.1 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 EMC81518.1 - 1.4e-34 119.0 5.4 1.4e-34 119.0 5.4 3.7 4 2 0 4 4 1 1 ADAM cysteine-rich Reprolysin_5 PF13688.6 EMC81518.1 - 1.2e-21 77.7 0.2 3.1e-21 76.4 0.2 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12 Disintegrin PF00200.23 EMC81518.1 - 1.4e-19 70.7 28.2 1.4e-19 70.7 28.2 4.6 4 1 0 4 4 3 1 Disintegrin Reprolysin_3 PF13582.6 EMC81518.1 - 4.2e-15 56.4 0.1 7.1e-15 55.6 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Pep_M12B_propep PF01562.19 EMC81518.1 - 3.3e-13 50.0 0.1 1.2e-12 48.3 0.1 1.9 1 1 0 1 1 1 1 Reprolysin family propeptide Reprolysin_4 PF13583.6 EMC81518.1 - 4.5e-12 46.0 0.1 7.2e-12 45.4 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EMC81518.1 - 2.4e-09 37.4 0.6 4.3e-09 36.5 0.6 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.13 EMC81518.1 - 0.00098 19.4 11.9 0.00098 19.4 11.9 5.7 5 1 0 5 5 4 1 EGF-like domain Peptidase_M57 PF12388.8 EMC81518.1 - 0.0073 15.9 1.6 0.013 15.1 1.6 1.3 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase EB PF01683.18 EMC81518.1 - 0.015 15.5 12.0 0.015 15.5 12.0 5.3 4 1 2 6 6 4 0 EB module Peptidase_M10 PF00413.24 EMC81518.1 - 0.025 14.4 0.1 0.044 13.6 0.1 1.4 1 0 0 1 1 1 0 Matrixin Peptidase_M66 PF10462.9 EMC81518.1 - 0.099 11.6 0.3 0.17 10.8 0.3 1.3 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M43 PF05572.13 EMC81518.1 - 1.9 8.4 6.6 0.13 12.2 0.2 2.2 2 0 0 2 2 2 0 Pregnancy-associated plasma protein-A Reprolysin PF01421.19 EMC81519.1 - 2.8e-56 190.6 0.2 5e-56 189.8 0.0 1.5 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 EMC81519.1 - 3.4e-28 98.4 0.9 3.4e-28 98.4 0.9 3.8 3 1 0 3 3 3 1 ADAM cysteine-rich Pep_M12B_propep PF01562.19 EMC81519.1 - 4.2e-20 72.4 0.0 6.6e-20 71.8 0.0 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide Disintegrin PF00200.23 EMC81519.1 - 5.4e-15 55.9 24.3 5.4e-15 55.9 24.3 3.4 3 0 0 3 3 3 1 Disintegrin Reprolysin_5 PF13688.6 EMC81519.1 - 3.6e-07 30.6 0.0 9.2e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EMC81519.1 - 0.0033 17.9 0.0 0.0062 17.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.13 EMC81519.1 - 0.0045 17.3 12.9 0.0045 17.3 12.9 4.7 5 1 0 5 5 5 1 EGF-like domain EB PF01683.18 EMC81519.1 - 0.024 14.9 15.1 0.024 14.9 15.1 5.1 4 1 1 5 5 5 0 EB module ADAM_CR_2 PF17771.1 EMC81519.1 - 0.089 13.3 0.5 0.089 13.3 0.5 5.7 2 1 2 5 5 5 0 ADAM cysteine-rich domain ADAM_CR PF08516.12 EMC81520.1 - 3.5e-12 46.7 0.2 3.5e-12 46.7 0.2 3.0 2 1 1 3 3 3 1 ADAM cysteine-rich EGF_2 PF07974.13 EMC81520.1 - 4.1e-05 23.9 12.9 4.1e-05 23.9 12.9 2.9 3 0 0 3 3 3 1 EGF-like domain EB PF01683.18 EMC81520.1 - 0.0029 17.8 18.3 0.0029 17.8 18.3 1.9 2 0 0 2 2 2 1 EB module hEGF PF12661.7 EMC81520.1 - 0.0067 17.0 9.9 0.0067 17.0 9.9 3.5 3 1 1 4 4 4 1 Human growth factor-like EGF EGF PF00008.27 EMC81520.1 - 0.042 14.1 12.4 0.042 14.1 12.4 2.8 2 0 0 2 2 2 0 EGF-like domain S_locus_glycop PF00954.20 EMC81520.1 - 0.069 13.7 8.4 0.098 13.2 8.2 1.4 1 1 0 1 1 1 0 S-locus glycoprotein domain ADAM_CR_2 PF17771.1 EMC81520.1 - 0.16 12.5 17.7 0.043 14.3 5.8 3.3 2 1 0 2 2 2 0 ADAM cysteine-rich domain EGF_Tenascin PF18720.1 EMC81520.1 - 1.4 9.1 5.6 8 6.6 0.4 2.7 2 0 0 2 2 2 0 Tenascin EGF domain IDO PF01231.18 EMC81522.1 - 1.5e-37 129.4 0.0 1.7e-37 129.2 0.0 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase Nif11 PF07862.11 EMC81522.1 - 0.1 12.9 0.0 0.26 11.6 0.0 1.6 1 0 0 1 1 1 0 Nif11 domain TC1 PF15063.6 EMC81523.1 - 3.1e-36 123.1 0.3 3.8e-36 122.8 0.3 1.1 1 0 0 1 1 1 1 Thyroid cancer protein 1 tRNA_bind_2 PF13725.6 EMC81523.1 - 0.006 16.3 1.1 0.0069 16.1 1.1 1.0 1 0 0 1 1 1 1 Possible tRNA binding domain MRP-S22 PF10245.9 EMC81523.1 - 0.021 14.6 1.6 0.025 14.3 1.6 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S22 zf-met PF12874.7 EMC81524.1 - 4.8e-28 96.7 25.4 9.4e-08 32.2 2.2 4.3 4 0 0 4 4 4 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMC81524.1 - 6e-24 83.8 16.8 4.4e-08 33.2 0.4 4.2 4 0 0 4 4 4 4 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EMC81524.1 - 1.3e-07 31.9 12.2 0.034 14.5 4.1 4.0 3 1 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-U1 PF06220.12 EMC81524.1 - 3.4e-06 26.7 17.4 0.0032 17.2 0.4 4.2 4 0 0 4 4 4 2 U1 zinc finger zf-C2H2_4 PF13894.6 EMC81524.1 - 0.0021 18.7 14.2 0.48 11.4 0.3 4.5 4 0 0 4 4 4 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC81524.1 - 0.022 15.2 3.7 22 5.7 0.6 3.9 3 0 0 3 3 3 0 Zinc-finger double domain DUF3449 PF11931.8 EMC81524.1 - 0.03 14.1 6.1 0.24 11.2 0.5 3.2 3 1 1 4 4 4 0 Domain of unknown function (DUF3449) CTU2 PF10288.9 EMC81524.1 - 0.046 14.0 11.4 0.3 11.3 0.7 3.9 2 1 0 3 3 3 0 Cytoplasmic tRNA 2-thiolation protein 2 zf-DBF PF07535.12 EMC81524.1 - 0.2 11.8 0.0 0.2 11.8 0.0 4.1 4 1 0 4 4 4 0 DBF zinc finger zf-C2H2 PF00096.26 EMC81524.1 - 1.7 9.2 12.3 4.8 7.8 0.7 3.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type Fz PF01392.22 EMC81525.1 - 2.1e-26 92.7 3.0 2.1e-26 92.7 3.0 1.9 2 0 0 2 2 2 1 Fz domain NTR PF01759.21 EMC81525.1 - 2e-15 56.5 0.3 3.3e-15 55.8 0.3 1.3 1 0 0 1 1 1 1 UNC-6/NTR/C345C module DUF555 PF04475.12 EMC81525.1 - 0.11 12.8 0.1 0.18 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF555) Erf4 PF10256.9 EMC81526.1 - 5.3e-22 78.1 0.0 5.9e-22 77.9 0.0 1.0 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Acyltransferase PF01553.21 EMC81528.1 - 2.4e-19 69.3 0.1 4.9e-19 68.3 0.1 1.5 1 0 0 1 1 1 1 Acyltransferase Topo_C_assoc PF14370.6 EMC81528.1 - 0.12 12.3 0.1 0.5 10.3 0.0 2.0 2 0 0 2 2 2 0 C-terminal topoisomerase domain Homeodomain PF00046.29 EMC81529.1 - 5.9e-22 77.3 1.0 9e-22 76.7 1.0 1.3 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 EMC81529.1 - 0.1 12.1 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Trypsin PF00089.26 EMC81530.1 - 1.3e-66 224.6 0.0 2e-66 224.0 0.0 1.3 1 0 0 1 1 1 1 Trypsin Kringle PF00051.18 EMC81530.1 - 1.7e-43 146.8 28.0 5e-23 81.2 4.5 3.1 3 0 0 3 3 3 2 Kringle domain Trypsin_2 PF13365.6 EMC81530.1 - 1.3e-06 29.3 0.0 2.4e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain EGF PF00008.27 EMC81530.1 - 0.0036 17.6 8.4 0.0036 17.6 8.4 4.1 5 0 0 5 5 5 1 EGF-like domain DUF316 PF03761.15 EMC81530.1 - 0.0073 15.9 0.1 2.3 7.7 0.0 2.4 2 0 0 2 2 2 2 Chymotrypsin family Peptidase-S1 hEGF PF12661.7 EMC81530.1 - 0.025 15.2 10.2 0.085 13.5 5.9 3.9 2 0 0 2 2 2 0 Human growth factor-like EGF DUF1986 PF09342.11 EMC81530.1 - 0.052 13.9 0.0 0.094 13.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) cEGF PF12662.7 EMC81530.1 - 3.4 7.7 8.3 0.44 10.5 1.3 3.3 3 0 0 3 3 3 0 Complement Clr-like EGF-like IKBKB_SDD PF18397.1 EMC81531.1 - 1e-132 441.6 16.9 1.6e-132 441.0 16.9 1.3 1 0 0 1 1 1 1 IQBAL scaffold dimerization domain Pkinase PF00069.25 EMC81531.1 - 2.8e-40 138.3 0.0 7.1e-40 137.0 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81531.1 - 1.1e-26 93.7 0.0 2.8e-26 92.4 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase IKKbetaNEMObind PF12179.8 EMC81531.1 - 7.7e-15 54.6 7.4 7.7e-15 54.6 7.4 2.7 2 0 0 2 2 2 1 I-kappa-kinase-beta NEMO binding domain Pkinase_fungal PF17667.1 EMC81531.1 - 1.6e-07 30.4 0.0 3.5e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EMC81531.1 - 0.00012 21.5 0.0 0.00028 20.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ubiquitin PF00240.23 EMC81531.1 - 0.0003 20.5 0.1 0.001 18.7 0.1 1.9 1 0 0 1 1 1 1 Ubiquitin family APH PF01636.23 EMC81531.1 - 0.0012 18.8 0.2 0.0063 16.5 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 EMC81531.1 - 0.0097 15.4 0.0 0.038 13.5 0.0 2.0 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL NPV_P10 PF05531.12 EMC81531.1 - 1.8 9.1 5.3 10 6.6 0.8 3.1 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein FliT PF05400.13 EMC81531.1 - 2.8 8.8 9.9 0.85 10.5 1.5 3.7 3 0 0 3 3 3 0 Flagellar protein FliT Porin_3 PF01459.22 EMC81532.1 - 1.5e-80 270.5 8.1 1.7e-80 270.4 8.1 1.0 1 0 0 1 1 1 1 Eukaryotic porin DNA_pol_B_palm PF14792.6 EMC81533.1 - 1.4e-39 134.8 0.1 2.9e-39 133.8 0.1 1.6 2 0 0 2 2 2 1 DNA polymerase beta palm DNA_pol_lambd_f PF10391.9 EMC81533.1 - 7.6e-22 76.9 0.0 1.6e-20 72.6 0.0 2.5 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda DNA_pol_B_thumb PF14791.6 EMC81533.1 - 3.7e-17 62.2 0.0 8.1e-17 61.2 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta thumb HHH_8 PF14716.6 EMC81533.1 - 2.6e-16 59.7 1.4 1.4e-14 54.1 0.7 2.6 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH_5 PF14520.6 EMC81533.1 - 2.6e-09 37.5 0.1 3.9e-06 27.4 0.0 2.6 2 0 0 2 2 2 2 Helix-hairpin-helix domain NTP_transf_2 PF01909.23 EMC81533.1 - 0.00018 21.7 0.0 0.00043 20.5 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain HHH_2 PF12826.7 EMC81533.1 - 0.0023 18.0 0.0 0.62 10.2 0.0 2.7 2 0 0 2 2 2 1 Helix-hairpin-helix motif Cdd1 PF11731.8 EMC81533.1 - 0.0055 16.9 0.0 0.042 14.1 0.0 2.3 2 1 0 2 2 2 1 Pathogenicity locus HHH_3 PF12836.7 EMC81533.1 - 0.007 16.6 0.2 3 8.2 0.0 3.6 4 1 0 4 4 4 1 Helix-hairpin-helix motif HHH PF00633.23 EMC81533.1 - 0.0095 15.8 0.2 5.2 7.1 0.2 2.7 2 0 0 2 2 2 1 Helix-hairpin-helix motif WSN PF02206.18 EMC81533.1 - 0.027 14.4 0.1 9.8 6.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF3701 PF12482.8 EMC81533.1 - 0.19 11.8 0.0 21 5.3 0.0 2.4 2 0 0 2 2 2 0 Phage integrase protein Sec7 PF01369.20 EMC81534.1 - 1.1e-39 136.1 0.1 1.5e-39 135.6 0.1 1.1 1 0 0 1 1 1 1 Sec7 domain F-box-like PF12937.7 EMC81534.1 - 3.2e-07 30.1 0.5 8.4e-07 28.8 0.5 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMC81534.1 - 0.004 17.0 1.1 0.0092 15.8 0.1 2.1 2 0 0 2 2 2 1 F-box domain HLH PF00010.26 EMC81535.1 - 1e-18 67.0 0.5 1e-18 67.0 0.5 1.6 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain HTH_51 PF18558.1 EMC81535.1 - 0.097 12.6 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain SCRG1 PF15224.6 EMC81537.1 - 2.6e-46 155.6 5.0 3e-46 155.4 5.0 1.0 1 0 0 1 1 1 1 Scrapie-responsive protein 1 SAP30_Sin3_bdg PF13867.6 EMC81538.1 - 2.5e-23 82.1 0.1 3.9e-23 81.5 0.1 1.3 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 zf-SAP30 PF13866.6 EMC81538.1 - 2.6e-13 49.9 1.3 6.1e-13 48.7 1.2 1.7 2 0 0 2 2 2 1 SAP30 zinc-finger HMG_box_2 PF09011.10 EMC81539.1 - 1.4e-42 144.2 14.3 4.3e-27 94.5 6.5 2.3 2 0 0 2 2 2 2 HMG-box domain HMG_box PF00505.19 EMC81539.1 - 1.4e-38 131.1 12.6 1.1e-25 89.8 1.5 2.5 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_5 PF14887.6 EMC81539.1 - 0.0047 16.9 11.6 0.28 11.2 2.9 2.3 2 0 0 2 2 2 2 HMG (high mobility group) box 5 DUF1244 PF06844.11 EMC81539.1 - 0.77 10.0 3.7 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1244) YABBY PF04690.13 EMC81539.1 - 3.2 8.3 7.3 0.26 11.8 1.1 2.0 1 1 1 2 2 2 0 YABBY protein Ribosomal_60s PF00428.19 EMC81539.1 - 7.5 7.2 25.4 15 6.3 24.5 2.0 1 1 1 2 2 2 0 60s Acidic ribosomal protein Glycos_transf_2 PF00535.26 EMC81540.1 - 1.6e-25 89.9 0.0 2.6e-25 89.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 EMC81540.1 - 2.4e-23 82.8 1.2 4.3e-23 81.9 1.2 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 EMC81540.1 - 0.00034 20.6 0.0 0.0012 18.8 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 EMC81540.1 - 0.00055 19.5 0.0 0.0013 18.3 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 EMC81540.1 - 0.0093 15.5 0.0 0.05 13.1 0.0 2.1 1 1 0 1 1 1 1 Glycosyltransferase like family 2 HCV_NS5a_1b PF08301.13 EMC81540.1 - 0.13 12.8 0.0 0.26 11.9 0.0 1.5 1 0 0 1 1 1 0 Hepatitis C virus non-structural 5a domain 1b Ricin_B_lectin PF00652.22 EMC81541.1 - 5.9e-26 91.2 0.5 8e-26 90.8 0.5 1.2 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glycos_transf_2 PF00535.26 EMC81541.1 - 2.7e-16 59.8 0.0 5.1e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_7C PF02709.14 EMC81541.1 - 8.1e-06 25.4 0.3 1.9e-05 24.2 0.3 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 EMC81541.1 - 0.0032 17.0 0.0 0.022 14.2 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.6 EMC81541.1 - 0.021 15.5 0.0 6.6 7.5 0.0 2.5 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like Glycos_transf_2 PF00535.26 EMC81542.1 - 8.6e-09 35.4 0.1 1.6e-08 34.6 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 RVT_1 PF00078.27 EMC81543.1 - 0.024 14.1 0.0 0.042 13.3 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Sad1_UNC PF07738.13 EMC81544.1 - 2.6e-36 124.6 0.0 4.1e-34 117.4 0.0 2.1 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal DUF5000 PF16391.5 EMC81544.1 - 0.1 12.7 0.0 0.15 12.2 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function Glycos_transf_2 PF00535.26 EMC81545.1 - 6.6e-32 110.7 0.0 1e-31 110.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 EMC81545.1 - 2.3e-22 79.6 1.3 3.4e-22 79.0 1.3 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 EMC81545.1 - 1.6e-07 31.5 0.0 1.5e-06 28.3 0.0 2.1 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 EMC81545.1 - 7.4e-05 22.3 0.1 0.00019 21.0 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase RicinB_lectin_2 PF14200.6 EMC81545.1 - 0.00019 22.1 0.2 1.2 9.9 0.1 2.5 2 0 0 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Glyco_tranf_2_2 PF10111.9 EMC81545.1 - 0.025 14.1 0.0 0.047 13.2 0.0 1.5 1 1 0 1 1 1 0 Glycosyltransferase like family 2 CBS PF00571.28 EMC81546.1 - 9.4e-33 112.5 3.3 2.6e-09 37.4 0.5 4.3 4 0 0 4 4 4 4 CBS domain IF-2 PF11987.8 EMC81546.1 - 0.09 12.9 0.2 0.17 12.0 0.2 1.4 1 0 0 1 1 1 0 Translation-initiation factor 2 Cbl_N3 PF02762.14 EMC81546.1 - 0.1 12.5 0.0 0.31 10.9 0.0 1.8 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, SH2-like domain Ras PF00071.22 EMC81547.1 - 3.5e-43 147.0 0.4 4.1e-43 146.8 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC81547.1 - 9.3e-14 51.7 0.0 1.8e-13 50.7 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC81547.1 - 3.3e-05 23.4 0.1 3.5e-05 23.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC81547.1 - 0.00014 21.5 0.1 0.00016 21.2 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EMC81547.1 - 0.0024 17.8 0.1 0.0043 17.0 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase SRPRB PF09439.10 EMC81547.1 - 0.061 12.7 0.1 0.11 11.9 0.1 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Crystall PF00030.19 EMC81548.1 - 1.4e-57 191.8 3.4 2.6e-31 107.7 0.4 2.0 2 0 0 2 2 2 2 Beta/Gamma crystallin IL4_i_Ig PF18258.1 EMC81548.1 - 8.4e-08 32.3 1.5 0.088 13.0 0.4 3.7 1 1 2 3 3 3 2 Interleukin-4 inducing immunoglobulin-binding domain Inhibitor_I36 PF03995.13 EMC81548.1 - 1.8e-05 24.6 0.1 0.0077 16.1 0.0 2.5 2 1 0 2 2 2 2 Peptidase inhibitor family I36 WD40 PF00400.32 EMC81549.1 - 1.3e-26 92.3 9.4 3.5e-06 27.7 0.1 6.8 6 1 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 EMC81549.1 - 1e-08 34.4 3.4 0.00075 18.3 0.0 4.7 3 2 1 5 5 5 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 EMC81549.1 - 1.8e-05 24.7 0.2 1.9 8.6 0.0 3.9 3 1 1 4 4 4 2 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 EMC81549.1 - 8.3e-05 22.1 0.0 0.00016 21.1 0.0 1.5 1 0 0 1 1 1 1 WD40-like domain PQQ_3 PF13570.6 EMC81549.1 - 0.00032 21.1 0.2 18 6.0 0.0 4.4 4 1 1 5 5 5 1 PQQ-like domain Nucleoporin_N PF08801.11 EMC81549.1 - 0.0057 15.5 2.2 0.31 9.7 0.1 3.4 1 1 3 4 4 4 1 Nup133 N terminal like Ubiquitin_5 PF18037.1 EMC81550.1 - 2e-34 117.8 1.2 7e-34 116.1 1.2 1.9 1 0 0 1 1 1 1 Ubiquitin-like domain UBA PF00627.31 EMC81550.1 - 1.3e-28 98.5 0.1 6e-09 35.6 0.0 3.7 3 0 0 3 3 3 3 UBA/TS-N domain HOIP-UBA PF16678.5 EMC81550.1 - 6.3e-06 26.3 10.8 0.00026 21.0 0.6 4.1 2 1 1 4 4 4 2 HOIP UBA domain pair UBA_4 PF14555.6 EMC81550.1 - 6.1e-05 22.7 0.1 0.13 12.1 0.1 3.4 3 0 0 3 3 3 1 UBA-like domain ubiquitin PF00240.23 EMC81550.1 - 0.00075 19.2 0.4 0.0058 16.4 0.6 2.3 2 0 0 2 2 2 1 Ubiquitin family TPR_2 PF07719.17 EMC81550.1 - 0.0087 16.1 8.2 0.86 9.9 0.4 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EMC81550.1 - 0.011 16.0 5.8 0.9 9.9 0.0 4.2 3 1 1 4 4 4 0 Tetratricopeptide repeat RuvA_C PF07499.13 EMC81550.1 - 0.016 15.6 0.1 20 5.7 0.0 3.7 3 0 0 3 3 3 0 RuvA, C-terminal domain TPR_8 PF13181.6 EMC81550.1 - 0.12 12.6 3.6 5.9 7.4 0.3 4.4 4 0 0 4 4 3 0 Tetratricopeptide repeat Rap1_C PF11626.8 EMC81550.1 - 0.14 12.2 0.7 9.1 6.5 0.0 3.6 4 0 0 4 4 4 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain UBA_3 PF09288.10 EMC81550.1 - 0.2 11.5 3.7 3.4 7.5 0.1 3.9 5 0 0 5 5 5 0 Fungal ubiquitin-associated domain TPR_1 PF00515.28 EMC81550.1 - 3 7.8 6.7 6.3 6.8 0.3 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4682 PF15733.5 EMC81551.1 - 1.2e-19 71.1 0.1 2.5e-19 70.1 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4682) FGGY_N PF00370.21 EMC81552.1 - 2.4e-18 66.6 0.0 2.3e-13 50.3 0.0 2.4 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 EMC81552.1 - 1.5e-06 28.1 0.0 6e-06 26.1 0.0 2.0 2 1 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain DUF3696 PF12476.8 EMC81552.1 - 0.12 12.8 0.0 0.25 11.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3696) Pkinase PF00069.25 EMC81554.1 - 3.7e-31 108.4 0.0 5.9e-31 107.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81554.1 - 3.5e-26 92.0 0.0 5.6e-26 91.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Activin_recp PF01064.23 EMC81554.1 - 2.2e-09 38.3 14.2 2.2e-09 38.3 14.2 1.9 2 0 0 2 2 2 1 Activin types I and II receptor domain Pkinase_fungal PF17667.1 EMC81554.1 - 0.0008 18.3 0.0 0.0015 17.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 EMC81554.1 - 0.18 11.4 0.0 0.38 10.4 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Toxin_TOLIP PF00087.21 EMC81554.1 - 4.4 7.6 14.1 0.5 10.6 9.6 1.8 2 0 0 2 2 2 0 Snake toxin and toxin-like protein Endonuclease_NS PF01223.23 EMC81555.1 - 2.3e-60 204.3 0.0 2.7e-60 204.0 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Exog_C PF18026.1 EMC81555.1 - 7.3e-28 96.4 1.0 1.4e-27 95.5 1.0 1.5 1 0 0 1 1 1 1 Endo/exonuclease (EXOG) C-terminal domain Ion_trans PF00520.31 EMC81556.1 - 1.3e-252 833.4 104.1 1.2e-78 263.7 17.6 4.1 4 0 0 4 4 4 4 Ion transport protein Na_trans_assoc PF06512.13 EMC81556.1 - 1.7e-65 221.1 5.7 1.7e-65 221.1 5.7 2.0 2 0 0 2 2 2 1 Sodium ion transport-associated Na_trans_cytopl PF11933.8 EMC81556.1 - 8.8e-59 198.9 5.5 1.6e-58 198.1 4.7 1.9 1 1 0 1 1 1 1 Cytoplasmic domain of voltage-gated Na+ ion channel PKD_channel PF08016.12 EMC81556.1 - 1.3e-11 43.9 87.1 8.6e-07 28.0 2.2 9.8 6 4 3 9 9 9 8 Polycystin cation channel GPHH PF16905.5 EMC81556.1 - 0.00025 20.8 0.0 0.0005 19.8 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated IQ PF00612.27 EMC81556.1 - 0.0041 16.8 0.8 0.0041 16.8 0.8 2.1 2 0 0 2 2 2 1 IQ calmodulin-binding motif COX16 PF14138.6 EMC81556.1 - 6.9 7.3 8.2 30 5.2 2.8 4.0 3 1 0 3 3 3 0 Cytochrome c oxidase assembly protein COX16 Ion_trans PF00520.31 EMC81557.1 - 2.6e-133 442.8 41.4 2.6e-79 265.9 16.3 2.2 2 0 0 2 2 2 2 Ion transport protein Na_trans_cytopl PF11933.8 EMC81557.1 - 6.9e-28 97.9 10.2 1.3e-27 97.1 10.2 1.4 1 0 0 1 1 1 1 Cytoplasmic domain of voltage-gated Na+ ion channel Na_trans_assoc PF06512.13 EMC81557.1 - 2.1e-23 83.7 1.2 2.1e-23 83.7 1.2 2.2 2 0 0 2 2 2 1 Sodium ion transport-associated PKD_channel PF08016.12 EMC81557.1 - 7.8e-05 21.5 10.1 7.8e-05 21.5 10.1 5.2 3 1 1 4 4 4 3 Polycystin cation channel Sarcoglycan_1 PF04790.13 EMC81557.1 - 0.072 12.4 0.3 1.9 7.8 0.1 2.4 2 0 0 2 2 2 0 Sarcoglycan complex subunit protein UPF0242 PF06785.11 EMC81557.1 - 1.3 9.1 11.1 0.18 11.9 3.2 2.6 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF3337 PF11816.8 EMC81558.1 - 3.8e-38 131.1 0.3 1.3e-37 129.3 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3337) WD40 PF00400.32 EMC81558.1 - 1.6e-29 101.5 7.0 4.6e-05 24.1 0.1 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC81558.1 - 3.2e-07 30.6 2.9 0.037 14.3 0.2 4.0 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 EMC81558.1 - 0.0077 15.0 0.5 0.89 8.2 0.0 3.2 1 1 2 3 3 3 1 Nup133 N terminal like WD40_like PF17005.5 EMC81558.1 - 0.012 15.0 0.0 0.032 13.6 0.0 1.7 1 0 0 1 1 1 0 WD40-like domain Nup160 PF11715.8 EMC81558.1 - 0.15 10.7 8.5 2 7.0 0.9 4.0 2 1 2 4 4 4 0 Nucleoporin Nup120/160 GRASP55_65 PF04495.14 EMC81559.1 - 4.8e-73 244.0 0.1 6e-56 188.6 0.0 2.5 2 1 1 3 3 3 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.6 EMC81559.1 - 3.6e-08 33.6 0.0 0.00011 22.5 0.0 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 EMC81559.1 - 4.3e-06 26.5 0.0 0.1 12.5 0.0 3.0 2 1 0 2 2 2 2 PDZ domain CSRNP_N PF16019.5 EMC81560.1 - 1.8e-104 348.4 9.2 3e-104 347.7 9.2 1.3 1 0 0 1 1 1 1 Cysteine/serine-rich nuclear protein N-terminus HNF-1_N PF04814.13 EMC81561.1 - 0.081 13.5 0.0 0.1 13.2 0.0 1.2 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus LIM PF00412.22 EMC81562.1 - 3.9e-08 33.4 11.1 4.5e-08 33.2 11.1 1.1 1 0 0 1 1 1 1 LIM domain Sugar_tr PF00083.24 EMC81563.1 - 4e-30 105.1 8.1 5.3e-30 104.7 8.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMC81563.1 - 5e-22 78.3 20.5 5e-22 78.3 20.5 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 EMC81563.1 - 0.0002 20.1 8.3 0.00045 18.9 2.5 2.2 2 0 0 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.7 EMC81563.1 - 0.00089 18.2 0.3 0.011 14.7 0.3 2.1 1 1 0 1 1 1 1 MFS_1 like family Pkinase PF00069.25 EMC81564.1 - 5.3e-42 144.0 0.0 7.2e-42 143.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81564.1 - 2.1e-29 102.6 0.0 3.3e-29 102.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.8 EMC81564.1 - 2.3e-21 75.8 0.0 4.1e-21 75.0 0.0 1.4 1 0 0 1 1 1 1 Oxidative-stress-responsive kinase 1 C-terminal domain Pkinase_fungal PF17667.1 EMC81564.1 - 0.0001 21.2 0.0 0.00016 20.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EMC81564.1 - 0.00014 21.3 0.0 0.00021 20.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC81564.1 - 0.2 11.0 0.0 0.42 9.9 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family 7tm_1 PF00001.21 EMC81565.1 - 5e-20 71.9 0.8 6.4e-20 71.6 0.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC81565.1 - 0.0058 16.1 1.4 0.0058 16.1 1.4 1.5 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx Clat_adaptor_s PF01217.20 EMC81566.1 - 1.7e-60 203.1 2.2 1.9e-60 202.9 2.2 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF629 PF04780.12 EMC81566.1 - 0.0022 16.6 0.5 0.0026 16.4 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF629) PulA_N1 PF17999.1 EMC81566.1 - 0.06 14.1 0.1 0.11 13.3 0.1 1.4 1 0 0 1 1 1 0 Pullulanase N1-terminal domain zf-CCCH PF00642.24 EMC81567.1 - 9.4e-13 47.7 13.0 1.5e-06 27.9 4.2 2.8 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EMC81567.1 - 2.9e-06 27.1 13.6 0.00019 21.4 2.3 2.7 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 EMC81567.1 - 6.7e-06 25.8 12.4 0.00046 19.9 4.3 2.6 2 0 0 2 2 2 2 CCCH-type zinc finger RRM_1 PF00076.22 EMC81567.1 - 9e-05 22.2 0.0 0.0002 21.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EMC81567.1 - 0.0056 16.7 0.1 0.011 15.7 0.1 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Torus PF16131.5 EMC81567.1 - 0.025 15.3 0.2 0.025 15.3 0.2 4.1 3 2 1 4 4 4 0 Torus domain DUF3430 PF11912.8 EMC81567.1 - 0.11 12.5 0.6 0.16 12.0 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3430) Collectrin PF16959.5 EMC81568.1 - 1e-70 236.5 1.1 1.3e-70 236.1 1.1 1.1 1 0 0 1 1 1 1 Renal amino acid transporter DUF2140 PF09911.9 EMC81568.1 - 0.011 15.3 0.2 0.14 11.7 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) MscL PF01741.18 EMC81568.1 - 0.028 14.7 0.1 0.043 14.1 0.1 1.5 1 1 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL CcmH PF03918.14 EMC81568.1 - 0.032 13.5 0.0 0.078 12.3 0.0 1.6 1 0 0 1 1 1 0 Cytochrome C biogenesis protein INSIG PF07281.12 EMC81568.1 - 0.047 13.3 0.2 0.49 10.0 0.2 2.0 2 0 0 2 2 2 0 Insulin-induced protein (INSIG) TMEM171 PF15471.6 EMC81568.1 - 0.055 12.5 0.0 0.08 11.9 0.0 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 Pilin_N PF07790.11 EMC81568.1 - 0.067 14.1 0.1 4.3 8.3 0.0 2.6 2 1 0 2 2 2 0 Archaeal Type IV pilin, N-terminal EphA2_TM PF14575.6 EMC81568.1 - 0.085 13.8 0.8 0.23 12.4 0.0 2.0 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF4381 PF14316.6 EMC81568.1 - 0.087 13.1 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) OAD_gamma PF04277.13 EMC81568.1 - 0.09 13.4 0.0 0.21 12.2 0.0 1.6 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain LYRIC PF15686.5 EMC81568.1 - 0.097 12.2 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family Peptidase_M2 PF01401.18 EMC81569.1 - 6.4e-213 708.5 4.8 3.6e-212 706.0 4.8 1.8 1 1 0 1 1 1 1 Angiotensin-converting enzyme Collectrin PF16959.5 EMC81569.1 - 2.9e-72 241.5 0.2 6.5e-72 240.3 0.2 1.6 1 0 0 1 1 1 1 Renal amino acid transporter PDGF PF00341.17 EMC81570.1 - 1e-22 80.2 9.5 1e-22 80.2 9.5 2.3 2 1 0 2 2 2 1 PDGF/VEGF domain CXCXC PF03128.14 EMC81570.1 - 0.048 14.1 4.3 0.048 14.1 4.3 6.6 6 0 0 6 6 6 0 CXCXC repeat Hid1 PF12722.7 EMC81571.1 - 6.8 4.7 36.9 12 3.8 36.9 1.4 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ank_2 PF12796.7 EMC81572.1 - 3.9e-30 104.3 3.9 1.4e-14 54.4 0.9 3.8 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC81572.1 - 2.7e-27 94.8 5.6 1.9e-08 34.7 0.1 4.5 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC81572.1 - 2.4e-25 85.8 5.5 0.0038 17.6 0.1 6.5 6 0 0 6 6 6 6 Ankyrin repeat Ank PF00023.30 EMC81572.1 - 8.7e-24 82.9 11.8 0.0014 19.0 0.1 6.5 6 0 0 6 6 6 6 Ankyrin repeat Ank_5 PF13857.6 EMC81572.1 - 7e-19 67.6 5.5 5.8e-05 23.3 0.2 5.4 2 2 3 5 5 5 5 Ankyrin repeats (many copies) SOCS_box PF07525.16 EMC81572.1 - 1.5e-09 38.0 4.4 2.8e-09 37.2 4.4 1.5 1 0 0 1 1 1 1 SOCS box GCFC PF07842.12 EMC81572.1 - 0.17 11.4 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 GC-rich sequence DNA-binding factor-like protein CRAL_TRIO PF00650.20 EMC81573.1 - 2e-29 102.3 0.3 3.3e-29 101.7 0.3 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain Motile_Sperm PF00635.26 EMC81573.1 - 3e-21 75.3 0.0 7.6e-21 74.0 0.0 1.7 1 0 0 1 1 1 1 MSP (Major sperm protein) domain CRAL_TRIO_2 PF13716.6 EMC81573.1 - 0.0021 18.2 0.1 0.0045 17.2 0.1 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Neur_chan_LBD PF02931.23 EMC81575.1 - 2.1e-52 177.7 0.0 2.8e-52 177.3 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC81575.1 - 1.9e-40 139.4 0.0 8e-34 117.7 0.0 2.2 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region LRR_8 PF13855.6 EMC81577.1 - 2e-30 104.4 40.1 3.1e-13 49.3 4.4 5.8 3 1 3 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EMC81577.1 - 9.1e-15 54.5 42.2 0.0006 20.1 3.7 7.0 3 1 5 8 8 8 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC81577.1 - 2.9e-09 36.7 9.8 0.0003 20.3 1.8 3.5 2 1 0 3 3 3 3 Leucine-rich repeat LRR_5 PF13306.6 EMC81577.1 - 8.3e-08 32.3 0.0 0.00027 20.9 0.0 3.6 1 1 3 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRRNT PF01462.18 EMC81577.1 - 0.00086 18.9 4.7 0.0027 17.3 3.0 2.6 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRRCT PF01463.24 EMC81577.1 - 0.0014 19.0 0.0 0.0045 17.4 0.0 1.9 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain fn3 PF00041.21 EMC81577.1 - 0.01 16.2 0.0 0.023 15.1 0.0 1.5 1 0 0 1 1 1 0 Fibronectin type III domain TPKR_C2 PF16920.5 EMC81577.1 - 0.079 13.1 0.8 0.27 11.4 0.2 2.3 2 0 0 2 2 2 0 Tyrosine-protein kinase receptor C2 Ig-like domain Methyltransf_11 PF08241.12 EMC81578.1 - 1.2e-21 77.1 0.0 1.9e-21 76.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC81578.1 - 1e-16 61.4 0.0 1.7e-16 60.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC81578.1 - 7.3e-16 58.4 0.0 1.1e-15 57.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC81578.1 - 2.8e-12 46.7 0.0 4.8e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC81578.1 - 3.1e-11 43.9 0.0 4.8e-11 43.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMC81578.1 - 4.5e-09 36.0 0.0 7.4e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_29 PF03141.16 EMC81578.1 - 5.9e-06 25.1 0.0 8e-06 24.7 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase MetW PF07021.12 EMC81578.1 - 0.00098 18.8 0.0 0.0015 18.2 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW MTS PF05175.14 EMC81578.1 - 0.002 17.7 0.0 0.0028 17.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 EMC81578.1 - 0.0057 16.6 0.0 0.0088 16.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 EMC81578.1 - 0.012 15.2 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_8 PF05148.15 EMC81578.1 - 0.022 14.6 0.0 0.035 14.0 0.0 1.3 1 0 0 1 1 1 0 Hypothetical methyltransferase Pox_MCEL PF03291.16 EMC81578.1 - 0.12 11.5 0.0 2.6 7.1 0.0 2.0 1 1 1 2 2 2 0 mRNA capping enzyme Methyltransf_PK PF05891.12 EMC81578.1 - 0.13 11.8 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Methyltransf_32 PF13679.6 EMC81578.1 - 0.19 11.7 0.0 0.29 11.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_7 PF03492.15 EMC81578.1 - 0.2 10.8 0.0 0.36 10.0 0.0 1.3 1 0 0 1 1 1 0 SAM dependent carboxyl methyltransferase Keratin_B2_2 PF13885.6 EMC81579.1 - 0.0059 16.5 101.0 1.4 9.0 27.8 4.2 1 1 3 4 4 4 3 Keratin, high sulfur B2 protein PMG PF05287.12 EMC81579.1 - 1.1 9.2 51.5 2.4 8.2 28.7 2.1 1 1 1 2 2 2 0 PMG protein Pentapeptide_4 PF13599.6 EMC81579.1 - 9.2 6.5 15.2 1.8e+04 -4.4 15.2 3.4 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) NUC153 PF08159.12 EMC81580.1 - 1.9e-10 40.4 1.2 1.9e-10 40.4 1.2 3.7 4 0 0 4 4 4 2 NUC153 domain Aminotran_1_2 PF00155.21 EMC81581.1 - 2.2e-55 188.3 0.0 2.9e-55 187.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EMC81581.1 - 0.00016 21.0 0.0 0.00025 20.4 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 EMC81581.1 - 0.00024 20.2 0.0 0.00035 19.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Raf1_HTH PF18579.1 EMC81581.1 - 0.087 12.5 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 Rubisco accumulation factor 1 helix turn helix domain Cyd_oper_YbgE PF09600.10 EMC81581.1 - 0.13 12.7 0.1 30 5.1 0.0 2.5 2 0 0 2 2 2 0 Cyd operon protein YbgE (Cyd_oper_YbgE) PHR PF08005.12 EMC81582.1 - 1.4e-43 149.2 0.9 1.4e-43 149.2 0.9 1.7 2 0 0 2 2 2 1 PHR domain BTB PF00651.31 EMC81582.1 - 5.2e-24 84.6 0.0 3.2e-23 82.1 0.0 2.2 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 EMC81582.1 - 8.8e-08 32.2 3.2 1.1e-07 31.9 1.3 2.2 2 1 0 2 2 2 1 BTB And C-terminal Kelch SR-25 PF10500.9 EMC81582.1 - 0.14 11.7 4.3 0.22 11.1 4.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein EGF PF00008.27 EMC81583.1 - 2.3e-80 264.4 285.5 2e-09 37.6 7.7 19.5 19 1 0 19 19 18 14 EGF-like domain hEGF PF12661.7 EMC81583.1 - 6.1e-53 175.8 258.8 4.8e-07 30.2 7.3 20.8 22 0 0 22 22 20 14 Human growth factor-like EGF MNNL PF07657.13 EMC81583.1 - 5.1e-28 96.9 3.4 5.1e-28 96.9 3.4 6.9 7 1 0 7 7 1 1 N terminus of Notch ligand EGF_2 PF07974.13 EMC81583.1 - 5.5e-27 93.8 329.9 0.00029 21.1 11.1 19.8 20 0 0 20 20 18 13 EGF-like domain DSL PF01414.19 EMC81583.1 - 4.4e-24 84.5 7.7 4.4e-24 84.5 7.7 15.5 12 2 4 16 16 14 3 Delta serrate ligand EGF_CA PF07645.15 EMC81583.1 - 8e-07 29.2 25.0 5.4e-05 23.3 8.7 19.5 11 4 11 22 22 17 11 Calcium-binding EGF domain DUF2920 PF11144.8 EMC81583.1 - 0.0042 16.3 0.6 0.0068 15.6 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2920) cEGF PF12662.7 EMC81583.1 - 0.011 15.7 3.3 0.011 15.7 3.3 17.8 16 3 0 16 16 15 0 Complement Clr-like EGF-like IN_DBD_C PF00552.21 EMC81583.1 - 0.052 12.8 0.3 0.44 9.9 0.3 2.5 1 1 0 1 1 1 0 Integrase DNA binding domain MAP17 PF15807.5 EMC81583.1 - 0.14 12.4 0.8 0.27 11.5 0.8 1.4 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 CLN3 PF02487.17 EMC81583.1 - 0.33 10.0 0.2 0.48 9.4 0.2 1.1 1 0 0 1 1 1 0 CLN3 protein Cpn60_TCP1 PF00118.24 EMC81584.1 - 1.1e-93 314.6 0.0 1.2e-93 314.4 0.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family SNAP-25 PF00835.19 EMC81585.1 - 2.2e-21 75.9 0.2 5.3e-21 74.7 0.2 1.7 1 0 0 1 1 1 1 SNAP-25 family DUF5089 PF17002.5 EMC81585.1 - 6.3e-07 29.5 4.9 8.6e-07 29.0 4.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5089) Exonuc_VII_L PF02601.15 EMC81585.1 - 0.14 11.7 7.4 0.85 9.1 7.4 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit Sec20 PF03908.13 EMC81585.1 - 0.34 10.8 3.6 0.26 11.2 0.6 2.1 2 0 0 2 2 2 0 Sec20 PMC2NT PF08066.12 EMC81585.1 - 0.43 11.3 4.6 2.3 9.0 0.6 2.8 2 1 0 2 2 2 0 PMC2NT (NUC016) domain V-SNARE_C PF12352.8 EMC81585.1 - 0.46 10.8 11.1 0.08 13.2 1.3 3.7 3 2 1 4 4 3 0 Snare region anchored in the vesicle membrane C-terminus SOAR PF16533.5 EMC81585.1 - 0.48 10.4 5.6 4.4 7.3 0.0 2.9 3 0 0 3 3 3 0 STIM1 Orai1-activating region Alanine_zipper PF11839.8 EMC81585.1 - 0.6 10.5 6.9 1.9 8.9 0.2 3.4 3 0 0 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein Spc7 PF08317.11 EMC81585.1 - 0.64 8.8 10.8 0.32 9.8 3.9 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Snapin_Pallidin PF14712.6 EMC81585.1 - 0.67 10.4 11.2 7 7.2 5.8 2.5 2 1 0 2 2 2 0 Snapin/Pallidin DUF349 PF03993.12 EMC81585.1 - 0.82 10.0 4.9 0.82 10.0 0.1 2.8 2 1 0 2 2 2 0 Domain of Unknown Function (DUF349) DUF1664 PF07889.12 EMC81585.1 - 0.91 9.6 9.0 2.8 8.0 1.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) TMPIT PF07851.13 EMC81585.1 - 1.1 8.4 5.2 1.2 8.3 0.9 2.0 2 0 0 2 2 2 0 TMPIT-like protein HisKA_3 PF07730.13 EMC81585.1 - 1.7 9.2 10.1 1.6 9.3 1.7 3.7 3 1 0 3 3 3 0 Histidine kinase Atg14 PF10186.9 EMC81585.1 - 2 7.4 8.4 3.2 6.8 0.4 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Laminin_II PF06009.12 EMC81585.1 - 2.2 8.3 8.8 7.7 6.5 1.2 2.8 2 1 0 2 2 2 0 Laminin Domain II FPRL1_inhibitor PF16104.5 EMC81585.1 - 2.3 8.4 4.5 9.8 6.4 0.2 2.8 2 1 1 3 3 3 0 Formyl peptide receptor-like 1 inhibitory protein DivIC PF04977.15 EMC81585.1 - 3.2 7.6 9.4 4.2 7.2 0.2 3.2 3 0 0 3 3 3 0 Septum formation initiator MIF4G_like_2 PF09090.11 EMC81585.1 - 4.2 6.8 5.9 0.96 8.9 1.8 1.8 2 0 0 2 2 2 0 MIF4G like V_ATPase_I PF01496.19 EMC81585.1 - 5.2 4.8 5.4 1.4 6.7 2.2 1.6 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family DUF4665 PF15679.5 EMC81585.1 - 5.3 7.7 6.5 4.6 7.9 0.8 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4665) Rx_N PF18052.1 EMC81585.1 - 5.8 7.3 8.8 0.39 11.0 0.3 2.7 2 1 0 2 2 2 0 Rx N-terminal domain IFT57 PF10498.9 EMC81585.1 - 6.3 5.7 12.7 16 4.3 5.7 2.9 2 1 0 2 2 2 0 Intra-flagellar transport protein 57 XhlA PF10779.9 EMC81585.1 - 6.5 7.0 16.8 5.2 7.3 0.9 3.6 3 1 1 4 4 4 0 Haemolysin XhlA Use1 PF09753.9 EMC81585.1 - 8.2 6.1 12.3 0.061 13.0 0.5 2.4 2 1 0 2 2 2 0 Membrane fusion protein Use1 Ank_2 PF12796.7 EMC81586.1 - 9.6e-52 173.5 4.7 6.8e-11 42.6 0.1 5.8 4 1 2 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC81586.1 - 4.6e-45 151.1 8.0 1.3e-10 41.3 0.1 8.5 4 3 5 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC81586.1 - 5.5e-43 140.0 6.0 3.4e-06 27.0 0.0 10.3 10 0 0 10 10 10 7 Ankyrin repeat Ank PF00023.30 EMC81586.1 - 2.9e-39 131.8 9.2 4.9e-06 26.7 0.0 9.9 11 0 0 11 11 11 7 Ankyrin repeat Ank_4 PF13637.6 EMC81586.1 - 9.7e-39 131.3 11.0 2.2e-14 53.6 0.1 7.9 4 2 5 9 9 9 9 Ankyrin repeats (many copies) DUF713 PF05218.14 EMC81586.1 - 0.06 13.1 0.6 0.11 12.2 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF713) adh_short PF00106.25 EMC81587.1 - 7.1e-22 77.8 0.0 1.2e-21 77.1 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC81587.1 - 2.6e-14 53.4 0.0 3.4e-14 53.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 EMC81587.1 - 3.2e-06 26.7 0.0 3.7e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) HMG_box PF00505.19 EMC81587.1 - 0.0015 18.9 0.6 0.0034 17.8 0.1 1.8 2 0 0 2 2 2 1 HMG (high mobility group) box Colicin_D PF11429.8 EMC81588.1 - 0.14 12.6 0.0 0.82 10.2 0.0 2.1 2 1 0 2 2 2 0 Colicin D Borrelia_P83 PF05262.11 EMC81591.1 - 1.6 7.1 42.1 2.5 6.5 42.1 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF4581 PF15167.6 EMC81592.1 - 5.9e-49 165.5 0.5 6.5e-49 165.4 0.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4581) Toxin_27 PF08099.11 EMC81592.1 - 0.11 12.6 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 Scorpion calcine family EAF PF09816.9 EMC81593.1 - 2.4e-16 60.0 0.0 6.2e-16 58.6 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor Macoilin PF09726.9 EMC81593.1 - 3.9 5.9 9.1 4.4 5.7 9.1 1.1 1 0 0 1 1 1 0 Macoilin family Methyltransf_12 PF08242.12 EMC81594.1 - 4.7e-17 62.5 0.1 3.9e-16 59.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC81594.1 - 7.3e-15 55.5 0.0 1.7e-14 54.3 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC81594.1 - 4.1e-13 49.5 0.0 5.8e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC81594.1 - 7e-11 42.6 0.1 2e-10 41.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC81594.1 - 2.5e-09 37.1 0.0 3.5e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EMC81594.1 - 0.00062 19.4 0.0 0.0011 18.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain CheR PF01739.18 EMC81594.1 - 0.041 13.3 0.4 5 6.5 0.1 2.4 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain SH3BP5 PF05276.14 EMC81595.1 - 5.9e-93 310.9 21.6 8e-93 310.5 21.6 1.2 1 0 0 1 1 1 1 SH3 domain-binding protein 5 (SH3BP5) DUF4200 PF13863.6 EMC81595.1 - 0.35 11.3 32.1 0.054 13.9 15.8 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) Peptidase_C98 PF15499.6 EMC81595.1 - 0.82 9.1 6.4 0.22 11.0 2.4 1.9 1 1 2 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase DUF812 PF05667.11 EMC81595.1 - 0.85 8.4 24.3 0.94 8.3 15.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF812) DUF4735 PF15882.5 EMC81595.1 - 2.3 7.6 7.4 1.5 8.2 1.2 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4735) MscS_porin PF12795.7 EMC81595.1 - 3 7.3 24.1 1.1 8.7 16.2 2.4 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain DUF5344 PF17279.2 EMC81595.1 - 3.2 8.4 8.7 2.8 8.6 0.1 3.3 2 1 1 3 3 3 0 Family of unknown function (DUF5344) Calpain_III PF01067.22 EMC81596.1 - 5.9e-14 52.5 1.0 0.00013 22.3 0.0 3.4 3 1 0 3 3 3 3 Calpain large subunit, domain III Peptidase_C2 PF00648.21 EMC81597.1 - 1.6e-28 99.6 0.3 3.6e-26 91.9 0.0 2.1 2 0 0 2 2 2 2 Calpain family cysteine protease MIT PF04212.18 EMC81597.1 - 2e-15 56.6 8.1 9.6e-13 48.0 3.9 2.4 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain T2SSF PF00482.23 EMC81597.1 - 0.035 14.1 2.0 0.044 13.8 0.2 2.0 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F Asp-B-Hydro_N PF05279.11 EMC81597.1 - 0.46 10.5 5.4 0.65 10.0 5.4 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region TPR_2 PF07719.17 EMC81597.1 - 0.61 10.3 0.1 0.61 10.3 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Use1 PF09753.9 EMC81597.1 - 1.2 8.8 9.6 4.2 7.0 9.6 1.8 1 1 0 1 1 1 0 Membrane fusion protein Use1 YtxH PF12732.7 EMC81597.1 - 5 7.7 6.8 2.8e+02 2.1 6.8 2.4 1 1 0 1 1 1 0 YtxH-like protein CUB PF00431.20 EMC81598.1 - 6.8e-05 23.2 0.0 2.4 8.6 0.0 4.3 4 0 0 4 4 4 2 CUB domain LapA_dom PF06305.11 EMC81598.1 - 0.061 13.1 0.1 0.13 12.0 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain CYYR1 PF10873.8 EMC81598.1 - 0.47 10.9 7.3 6.5 7.2 0.3 2.5 2 0 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 Lectin_C PF00059.21 EMC81599.1 - 1e-17 64.8 0.1 1.8e-17 64.0 0.1 1.4 2 0 0 2 2 2 1 Lectin C-type domain DUF333 PF03891.15 EMC81599.1 - 0.0035 17.5 0.2 1.4 9.2 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF333) Chordopox_A33R PF05966.12 EMC81599.1 - 0.0037 16.6 0.1 0.0051 16.1 0.1 1.2 1 0 0 1 1 1 1 Chordopoxvirus A33R protein RNase_PH PF01138.21 EMC81600.1 - 6.8e-24 84.8 0.0 1e-23 84.3 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EMC81600.1 - 1.9e-10 40.6 0.1 4.7e-10 39.3 0.1 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 DHHC PF01529.20 EMC81601.1 - 3.7e-37 127.4 14.2 3.7e-37 127.4 14.2 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF3615 PF12274.8 EMC81601.1 - 0.0036 17.8 0.9 0.0068 16.9 0.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3615) IGFBP PF00219.18 EMC81601.1 - 2.7 8.7 13.6 34 5.2 10.5 2.4 2 0 0 2 2 2 0 Insulin-like growth factor binding protein Transglut_N PF00868.20 EMC81602.1 - 4.9e-31 107.5 0.0 1.3e-30 106.2 0.0 1.8 1 0 0 1 1 1 1 Transglutaminase family Transglut_C PF00927.22 EMC81602.1 - 7.6e-20 71.0 0.2 4e-12 46.2 0.0 2.6 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_core PF01841.19 EMC81602.1 - 8.1e-16 58.5 0.1 1.7e-15 57.4 0.1 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily APS-reductase_C PF12139.8 EMC81602.1 - 0.062 13.5 0.1 0.15 12.3 0.1 1.6 1 0 0 1 1 1 0 Adenosine-5'-phosphosulfate reductase beta subunit DUF4604 PF15377.6 EMC81603.1 - 1e-28 100.9 14.9 1.3e-28 100.6 14.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) Asp-B-Hydro_N PF05279.11 EMC81603.1 - 0.078 13.0 8.4 0.098 12.7 8.4 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Arm PF00514.23 EMC81606.1 - 5.6e-38 127.8 16.4 9e-08 31.9 0.1 12.3 13 0 0 13 13 13 6 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 EMC81606.1 - 1.4e-08 35.0 1.1 0.0052 16.9 0.2 4.2 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EMC81606.1 - 2e-06 28.1 5.4 0.027 14.8 0.2 4.4 4 0 0 4 4 4 1 HEAT repeats Adaptin_N PF01602.20 EMC81606.1 - 1.3e-05 24.0 2.2 0.0078 14.8 1.1 3.2 3 0 0 3 3 3 2 Adaptin N terminal region HEAT PF02985.22 EMC81606.1 - 0.00012 22.0 1.6 20 5.8 0.0 5.3 4 0 0 4 4 4 0 HEAT repeat HEAT_EZ PF13513.6 EMC81606.1 - 0.00014 22.3 7.1 0.64 10.6 0.3 5.4 4 1 1 5 5 5 2 HEAT-like repeat KAP PF05804.12 EMC81606.1 - 0.00039 18.7 0.4 0.033 12.3 0.0 3.2 3 1 1 4 4 4 1 Kinesin-associated protein (KAP) Atx10homo_assoc PF09759.9 EMC81606.1 - 0.0024 17.8 1.8 0.018 15.0 0.2 3.3 3 2 1 4 4 4 1 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 EMC81606.1 - 0.0062 16.0 1.9 0.68 9.3 0.0 3.6 3 1 0 3 3 3 1 Armadillo-like DUF3361 PF11841.8 EMC81606.1 - 0.015 15.3 4.0 1.7 8.6 0.0 4.2 4 1 1 5 5 5 0 Domain of unknown function (DUF3361) Queuosine_synth PF02547.15 EMC81606.1 - 0.025 13.7 0.1 0.045 12.9 0.1 1.3 1 0 0 1 1 1 0 Queuosine biosynthesis protein RasGEF_N_2 PF14663.6 EMC81606.1 - 0.027 14.9 5.0 6.5 7.2 0.0 4.3 4 2 1 5 5 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain DUF3361 PF11841.8 EMC81607.1 - 0.38 10.7 5.4 0.42 10.5 3.8 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF3361) HEAT PF02985.22 EMC81608.1 - 0.00049 20.1 0.3 1.1 9.7 0.1 3.9 3 0 0 3 3 3 1 HEAT repeat IFRD PF05004.13 EMC81608.1 - 0.0019 17.4 7.7 0.035 13.2 0.1 3.1 3 1 1 4 4 4 2 Interferon-related developmental regulator (IFRD) DUF3385 PF11865.8 EMC81608.1 - 0.0023 17.9 0.2 0.023 14.6 0.2 2.8 1 1 0 1 1 1 1 Domain of unknown function (DUF3385) HEAT_2 PF13646.6 EMC81608.1 - 0.0027 18.1 0.1 0.7 10.3 0.0 3.5 3 0 0 3 3 3 1 HEAT repeats RICTOR_V PF14668.6 EMC81608.1 - 0.022 15.0 2.9 19 5.6 0.1 3.6 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, domain 5 MgrB PF13998.6 EMC81608.1 - 0.11 12.4 0.2 5.4 7.0 0.1 2.5 2 0 0 2 2 2 0 MgrB protein HAP1_N PF04849.13 EMC81609.1 - 3.4e-134 446.9 37.3 4.6e-134 446.5 37.3 1.2 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Milton PF12448.8 EMC81609.1 - 2.2e-64 216.8 7.9 2.2e-64 216.8 7.9 2.8 3 0 0 3 3 3 1 Kinesin associated protein KASH_CCD PF14662.6 EMC81609.1 - 0.0054 16.6 39.2 0.0091 15.8 12.3 3.4 1 1 2 3 3 3 2 Coiled-coil region of CCDC155 or KASH DUF1664 PF07889.12 EMC81609.1 - 0.24 11.4 16.5 0.23 11.5 1.2 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) BSD PF03909.17 EMC81609.1 - 0.31 11.1 1.4 4.5 7.4 0.1 3.0 2 0 0 2 2 2 0 BSD domain Mod_r PF07200.13 EMC81609.1 - 0.94 9.6 33.0 0.67 10.0 10.1 3.6 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Rootletin PF15035.6 EMC81609.1 - 1.6 8.7 37.9 0.19 11.7 6.9 3.3 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion CorA PF01544.18 EMC81609.1 - 2.4 7.4 16.7 0.75 9.1 8.3 2.9 3 0 0 3 3 3 0 CorA-like Mg2+ transporter protein ATG16 PF08614.11 EMC81609.1 - 2.7 8.2 36.0 4.5 7.4 22.9 2.8 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Shugoshin_N PF07558.11 EMC81609.1 - 2.7 7.9 9.3 3.2 7.7 0.3 3.9 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region DUF4226 PF10774.9 EMC81609.1 - 3.7 7.9 8.6 0.27 11.5 2.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4226) YabA PF06156.13 EMC81609.1 - 5.9 7.6 30.4 4.7 7.9 3.2 4.4 2 1 2 4 4 4 0 Initiation control protein YabA TPR_MLP1_2 PF07926.12 EMC81609.1 - 9.1 6.4 34.2 4.4 7.4 18.7 3.9 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein TUDOR PF00567.24 EMC81610.1 - 3.1e-21 75.7 0.3 9.3e-21 74.1 0.3 1.9 1 0 0 1 1 1 1 Tudor domain Pkinase PF00069.25 EMC81610.1 - 3.1e-16 59.5 0.0 1e-15 57.8 0.0 1.9 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81610.1 - 1.5e-12 47.3 0.0 3e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase SMN PF06003.12 EMC81610.1 - 0.00061 19.1 0.0 0.0016 17.7 0.0 1.7 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) SNase PF00565.17 EMC81610.1 - 0.0079 16.7 0.0 0.021 15.3 0.0 1.8 1 0 0 1 1 1 1 Staphylococcal nuclease homologue PHM7_cyt PF14703.6 EMC81610.1 - 0.029 14.6 0.5 0.029 14.6 0.5 3.3 2 2 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter Elf-1_N PF12310.8 EMC81610.1 - 1.1 9.9 4.8 1.9 9.1 0.3 2.8 2 0 0 2 2 2 0 Transcription factor protein N terminal DUF4525 PF15027.6 EMC81611.1 - 4.7e-76 253.1 0.4 5.8e-76 252.8 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4525) DUF4407 PF14362.6 EMC81611.1 - 0.0035 16.7 0.3 0.16 11.3 0.0 2.0 2 0 0 2 2 2 2 Domain of unknown function (DUF4407) RRM_1 PF00076.22 EMC81612.1 - 7.9e-20 70.5 0.0 1.1e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EMC81612.1 - 0.18 11.8 0.0 0.33 11.0 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif Apt1 PF10351.9 EMC81612.1 - 0.24 10.2 12.7 0.26 10.1 12.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 EMC81612.1 - 1.3 7.7 6.0 1.6 7.4 6.0 1.1 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 EMC81612.1 - 1.7 7.4 7.0 2 7.1 7.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Macoilin PF09726.9 EMC81612.1 - 3.4 6.1 7.9 3.6 6.0 7.9 1.1 1 0 0 1 1 1 0 Macoilin family KH_1 PF00013.29 EMC81613.1 - 9.1e-59 195.2 13.3 3.3e-15 55.7 0.1 5.0 5 0 0 5 5 5 4 KH domain RRM_1 PF00076.22 EMC81613.1 - 2.9e-17 62.2 0.0 6.7e-09 35.4 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_2 PF07650.17 EMC81613.1 - 5.8e-16 58.1 5.8 0.0034 17.2 0.1 4.6 4 0 0 4 4 4 4 KH domain KH_4 PF13083.6 EMC81613.1 - 6.3e-15 54.8 0.4 0.0024 17.7 0.0 4.7 4 0 0 4 4 4 4 KH domain KH_5 PF13184.6 EMC81613.1 - 6e-07 29.5 5.9 0.61 10.2 0.1 4.3 4 0 0 4 4 4 3 NusA-like KH domain MOEP19 PF16005.5 EMC81613.1 - 1.3e-05 25.1 0.1 0.14 12.1 0.0 4.3 5 0 0 5 5 5 1 KH-like RNA-binding domain RRM_5 PF13893.6 EMC81613.1 - 4e-05 23.2 0.0 0.023 14.3 0.0 2.4 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4041 PF13250.6 EMC81613.1 - 0.26 11.2 1.2 0.52 10.2 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4041) RsfS PF02410.15 EMC81614.1 - 1.1e-19 70.7 0.2 1.5e-19 70.3 0.2 1.2 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation Mlo PF03094.15 EMC81614.1 - 0.0043 15.5 0.2 0.005 15.3 0.2 1.0 1 0 0 1 1 1 1 Mlo family Kelch_1 PF01344.25 EMC81618.1 - 3e-46 154.8 14.2 4.2e-13 48.6 0.5 5.8 6 0 0 6 6 6 5 Kelch motif BACK PF07707.15 EMC81618.1 - 3e-34 117.2 1.0 3.1e-33 114.0 0.1 2.7 3 0 0 3 3 3 1 BTB And C-terminal Kelch Kelch_6 PF13964.6 EMC81618.1 - 2.6e-29 100.5 6.9 1.5e-09 37.8 0.0 6.3 2 1 4 6 6 6 5 Kelch motif BTB PF00651.31 EMC81618.1 - 1.2e-28 99.5 1.2 1.2e-28 99.5 1.2 1.8 2 0 0 2 2 2 1 BTB/POZ domain Kelch_4 PF13418.6 EMC81618.1 - 3.4e-23 81.4 0.1 1.4e-08 34.6 0.0 5.5 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 EMC81618.1 - 1.2e-21 75.7 6.1 1.5e-06 27.9 0.1 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 EMC81618.1 - 4.1e-13 49.3 4.8 0.00041 20.6 0.0 5.8 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC81618.1 - 8e-10 38.5 3.2 0.059 13.4 0.0 4.9 5 0 0 5 5 5 3 Kelch motif Glyoxal_oxid_N PF07250.11 EMC81618.1 - 0.033 13.4 1.0 0.16 11.1 0.2 2.4 2 1 1 3 3 3 0 Glyoxal oxidase N-terminus UvrD-helicase PF00580.21 EMC81618.1 - 0.1 12.1 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain ADPRTs_Tse2 PF18648.1 EMC81618.1 - 0.15 12.1 0.0 0.27 11.3 0.0 1.3 1 0 0 1 1 1 0 Tse2 ADP-ribosyltransferase toxins Hyccin PF09790.9 EMC81619.1 - 1e-130 435.5 1.0 1.7e-130 434.8 1.0 1.3 1 0 0 1 1 1 1 Hyccin IL6 PF00489.17 EMC81620.1 - 1.8e-47 161.3 0.8 2.1e-47 161.1 0.8 1.0 1 0 0 1 1 1 1 Interleukin-6/G-CSF/MGF family GCSF PF16647.5 EMC81620.1 - 0.00016 21.6 0.0 0.00017 21.4 0.0 1.1 1 0 0 1 1 1 1 Granulocyte colony-stimulating factor IL11 PF07400.11 EMC81620.1 - 0.0082 15.8 0.0 0.01 15.5 0.0 1.2 1 0 0 1 1 1 1 Interleukin 11 PSRP-3_Ycf65 PF04839.13 EMC81620.1 - 0.027 14.7 0.0 4.5 7.6 0.1 2.2 2 0 0 2 2 2 0 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65) IL23 PF16649.5 EMC81620.1 - 0.084 12.9 0.0 0.18 11.8 0.0 1.6 1 1 0 1 1 1 0 Interleukin 23 subunit alpha DUF5481 PF17578.2 EMC81620.1 - 0.14 12.6 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5481) RasGEF PF00617.19 EMC81621.1 - 1.2e-51 175.5 2.5 2.7e-51 174.3 2.5 1.7 1 0 0 1 1 1 1 RasGEF domain DEP PF00610.21 EMC81621.1 - 1.2e-15 57.4 0.1 3.2e-15 55.9 0.1 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RasGEF_N PF00618.20 EMC81621.1 - 1.6e-09 38.0 0.8 1.6e-09 38.0 0.8 2.4 2 0 0 2 2 2 1 RasGEF N-terminal motif RA PF00788.23 EMC81621.1 - 0.0043 17.6 0.1 0.018 15.7 0.1 2.1 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain MAGE PF01454.19 EMC81621.1 - 0.41 10.3 5.8 0.36 10.5 1.6 2.6 2 1 1 3 3 3 0 MAGE family zf-4CXXC_R1 PF10497.9 EMC81622.1 - 3.9e-37 126.5 10.2 6.7e-37 125.7 10.2 1.4 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 E7 PF00527.18 EMC81622.1 - 7 6.9 7.5 0.88 9.8 0.2 3.0 3 0 0 3 3 3 0 E7 protein, Early protein AAA_7 PF12775.7 EMC81624.1 - 1.5e-11 44.1 0.0 1.8e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_25 PF13481.6 EMC81624.1 - 0.044 13.3 0.0 0.049 13.2 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_6 PF12774.7 EMC81625.1 - 1.4e-09 37.4 0.1 1.6e-09 37.2 0.1 1.0 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region zf-H2C2_2 PF13465.6 EMC81626.1 - 1e-13 51.0 8.8 2.1e-08 34.2 2.5 3.9 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 EMC81626.1 - 7.8e-11 41.8 31.3 1.8e-05 24.9 1.1 3.7 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC81626.1 - 5.8e-06 26.7 30.1 0.00035 21.1 2.8 3.7 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC81626.1 - 0.016 15.2 16.6 0.044 13.8 2.2 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EMC81626.1 - 0.063 13.6 6.0 0.055 13.8 3.5 2.2 2 0 0 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 EMC81626.1 - 0.1 12.9 4.1 2.1 8.7 1.1 2.8 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding ABC_membrane PF00664.23 EMC81627.1 - 1.4e-129 431.6 35.6 2.8e-70 237.1 16.9 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EMC81627.1 - 8.5e-73 243.3 4.9 2.2e-37 128.6 0.1 2.9 3 0 0 3 3 2 2 ABC transporter SMC_N PF02463.19 EMC81627.1 - 3.8e-18 65.7 0.0 1.9e-07 30.8 0.0 3.3 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EMC81627.1 - 7.6e-10 39.2 0.8 0.00062 20.1 0.1 3.1 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EMC81627.1 - 1.6e-09 38.4 4.6 0.00032 21.1 0.2 3.1 2 1 1 3 3 3 2 AAA ATPase domain ABC_ATPase PF09818.9 EMC81627.1 - 4.8e-08 32.2 2.9 0.00046 19.1 0.1 2.8 3 0 0 3 3 3 2 Predicted ATPase of the ABC class Rad17 PF03215.15 EMC81627.1 - 1.3e-06 28.5 0.2 0.072 13.0 0.0 2.7 2 1 0 2 2 2 2 Rad17 P-loop domain RsgA_GTPase PF03193.16 EMC81627.1 - 1.9e-06 27.9 0.0 0.059 13.3 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_15 PF13175.6 EMC81627.1 - 4.8e-06 26.5 0.0 0.012 15.3 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain AAA_28 PF13521.6 EMC81627.1 - 2e-05 24.9 0.6 0.14 12.4 0.0 3.3 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.6 EMC81627.1 - 2.2e-05 24.3 3.5 0.12 12.1 0.3 3.4 2 2 0 2 2 2 2 AAA domain G-alpha PF00503.20 EMC81627.1 - 3.4e-05 23.2 0.1 0.036 13.2 0.0 2.4 2 1 0 2 2 2 2 G-protein alpha subunit AAA_7 PF12775.7 EMC81627.1 - 0.00012 21.7 0.0 0.4 10.2 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_5 PF07728.14 EMC81627.1 - 0.00018 21.5 0.2 0.74 9.8 0.0 3.7 3 1 1 4 4 4 1 AAA domain (dynein-related subfamily) AAA PF00004.29 EMC81627.1 - 0.00023 21.6 5.4 0.39 11.2 1.0 4.4 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EMC81627.1 - 0.00038 20.2 1.4 0.84 9.4 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain Zeta_toxin PF06414.12 EMC81627.1 - 0.0011 18.3 3.1 0.064 12.5 0.0 3.5 4 0 0 4 4 4 1 Zeta toxin SbcCD_C PF13558.6 EMC81627.1 - 0.0014 18.8 4.0 2.3 8.5 0.2 4.0 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.6 EMC81627.1 - 0.0047 16.8 0.0 5.4 6.7 0.0 4.0 3 1 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system ATP-synt_ab PF00006.25 EMC81627.1 - 0.0076 15.9 0.1 5.1 6.7 0.0 2.8 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_18 PF13238.6 EMC81627.1 - 0.0092 16.5 0.3 1.1 9.8 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.6 EMC81627.1 - 0.012 15.2 0.1 1.4 8.4 0.0 2.9 3 0 0 3 3 3 0 AAA domain PRK PF00485.18 EMC81627.1 - 0.013 15.3 0.0 1.4 8.6 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family RNA_helicase PF00910.22 EMC81627.1 - 0.014 15.8 0.0 4.2 7.8 0.0 2.9 2 0 0 2 2 2 0 RNA helicase IstB_IS21 PF01695.17 EMC81627.1 - 0.025 14.3 1.8 27 4.5 0.0 4.0 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_24 PF13479.6 EMC81627.1 - 0.035 13.8 0.6 6.7 6.4 0.0 2.7 3 0 0 3 3 2 0 AAA domain Viral_helicase1 PF01443.18 EMC81627.1 - 0.038 13.7 0.0 11 5.6 0.0 2.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 EMC81627.1 - 0.05 13.0 0.0 4.3 6.7 0.0 2.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 EMC81627.1 - 0.054 12.6 0.4 2.3 7.3 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF815) CDC45 PF02724.14 EMC81627.1 - 0.054 11.8 3.6 0.091 11.0 3.6 1.3 1 0 0 1 1 1 0 CDC45-like protein AAA_14 PF13173.6 EMC81627.1 - 0.068 13.2 0.2 8.8 6.4 0.0 3.7 3 1 1 4 4 4 0 AAA domain APS_kinase PF01583.20 EMC81627.1 - 0.07 13.0 0.1 0.89 9.4 0.0 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_33 PF13671.6 EMC81627.1 - 0.095 12.9 0.2 11 6.2 0.0 3.2 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.17 EMC81627.1 - 0.12 12.5 3.5 2 8.5 0.0 3.5 4 0 0 4 4 4 0 Helicase HerA, central domain NACHT PF05729.12 EMC81627.1 - 0.12 12.2 0.2 7.7 6.4 0.0 2.5 2 0 0 2 2 2 0 NACHT domain GAGA_bind PF06217.12 EMC81627.1 - 0.31 11.3 2.1 0.52 10.5 2.1 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family AAA_19 PF13245.6 EMC81627.1 - 0.97 9.8 4.4 18 5.7 0.2 3.4 2 2 0 2 2 2 0 AAA domain Integrin_beta PF00362.18 EMC81628.1 - 4.8e-98 327.8 0.0 7.4e-98 327.1 0.0 1.3 1 0 0 1 1 1 1 Integrin beta chain VWA domain PSI_integrin PF17205.3 EMC81628.1 - 1.3e-11 44.0 4.2 1.3e-11 44.0 4.2 4.2 5 0 0 5 5 5 1 Integrin plexin domain EGF_2 PF07974.13 EMC81628.1 - 2.8e-07 30.8 56.9 4.9e-05 23.6 13.9 5.1 5 0 0 5 5 5 3 EGF-like domain VWA PF00092.28 EMC81628.1 - 0.034 14.4 0.2 0.83 9.9 0.2 2.3 1 1 0 1 1 1 0 von Willebrand factor type A domain EGF_Tenascin PF18720.1 EMC81628.1 - 0.045 13.8 28.8 0.11 12.6 1.7 4.2 3 0 0 3 3 3 0 Tenascin EGF domain Sigma_reg_N PF13800.6 EMC81628.1 - 0.19 12.1 0.8 0.41 11.0 0.8 1.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal I-EGF_1 PF18372.1 EMC81628.1 - 0.29 11.3 45.8 0.032 14.3 7.5 4.7 4 0 0 4 4 4 0 Integrin beta epidermal growth factor like domain 1 Death PF00531.22 EMC81629.1 - 5.2e-05 23.3 1.0 0.37 11.0 0.1 3.1 2 1 1 3 3 3 2 Death domain ZU5 PF00791.20 EMC81629.1 - 0.00023 21.4 0.1 0.00055 20.2 0.1 1.6 1 0 0 1 1 1 1 ZU5 domain SH3_2 PF07653.17 EMC81629.1 - 0.00076 19.1 0.1 0.0015 18.2 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain ABC_membrane_3 PF13748.6 EMC81630.1 - 0.068 12.4 0.5 0.12 11.6 0.5 1.4 1 0 0 1 1 1 0 ABC transporter transmembrane region SHS2_Rpb7-N PF03876.17 EMC81631.1 - 7.6e-10 39.0 0.0 1.8e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RPA43_OB PF17875.1 EMC81631.1 - 6.1e-05 23.6 17.7 0.035 14.7 17.7 3.9 1 1 0 1 1 1 1 RPA43 OB domain in RNA Pol I RR_TM4-6 PF06459.12 EMC81631.1 - 0.62 9.8 16.8 0.83 9.4 16.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 HLH PF00010.26 EMC81632.1 - 4.5e-17 61.8 0.6 4.5e-17 61.8 0.6 1.7 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Hist_deacetyl PF00850.19 EMC81633.1 - 3e-81 273.3 0.0 3e-81 273.3 0.0 2.4 3 0 0 3 3 3 1 Histone deacetylase domain HDAC4_Gln PF12203.8 EMC81633.1 - 1.9e-34 117.7 45.9 1.9e-34 117.7 45.9 4.0 4 0 0 4 4 4 1 Glutamine rich N terminal domain of histone deacetylase 4 DUF4263 PF14082.6 EMC81633.1 - 6.1 7.1 10.2 14 5.9 1.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4263) PXA PF02194.15 EMC81634.1 - 7e-53 179.3 0.6 2.6e-51 174.2 0.3 2.8 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 EMC81634.1 - 3.6e-24 85.5 1.6 2e-19 70.2 0.0 4.2 4 0 0 4 4 4 2 Sorting nexin C terminal PX PF00787.24 EMC81634.1 - 6e-23 81.0 0.4 6e-23 81.0 0.4 2.3 2 0 0 2 2 2 1 PX domain RGS PF00615.19 EMC81634.1 - 3e-21 75.9 3.8 1.9e-19 70.1 0.2 3.6 3 0 0 3 3 3 1 Regulator of G protein signaling domain DUF1664 PF07889.12 EMC81634.1 - 0.032 14.3 1.7 9.8 6.2 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.9 EMC81634.1 - 0.08 13.3 3.2 0.26 11.6 0.4 3.1 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PAS_3 PF08447.12 EMC81635.1 - 6.2e-19 68.1 0.1 1.9e-12 47.3 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 EMC81635.1 - 7e-14 51.9 2.2 3.6e-10 40.0 0.0 3.5 3 0 0 3 3 3 2 PAS domain PAS PF00989.25 EMC81635.1 - 1.3e-12 47.7 2.9 1.4e-11 44.4 0.0 2.9 3 0 0 3 3 3 1 PAS fold HLH PF00010.26 EMC81635.1 - 6.2e-06 26.1 0.2 1.4e-05 25.0 0.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_4 PF08448.10 EMC81635.1 - 0.011 15.9 2.3 0.09 13.0 0.0 2.7 3 0 0 3 3 3 0 PAS fold PAS_9 PF13426.7 EMC81635.1 - 0.045 14.0 0.0 0.36 11.1 0.0 2.3 2 0 0 2 2 2 0 PAS domain Thioredoxin_7 PF13899.6 EMC81636.1 - 1.2e-25 89.5 0.3 2.7e-25 88.4 0.1 1.6 2 0 0 2 2 2 1 Thioredoxin-like Thioredox_DsbH PF03190.15 EMC81636.1 - 3.7e-06 27.0 0.0 5e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_2 PF13098.6 EMC81636.1 - 9.6e-06 26.0 0.3 3.1e-05 24.4 0.3 1.7 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 EMC81637.1 - 6.7e-24 83.9 0.0 1.3e-23 82.9 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EMC81637.1 - 0.0081 16.6 0.1 0.059 13.8 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Tetraspanin PF00335.20 EMC81638.1 - 3.1e-15 56.5 11.7 3.9e-15 56.2 11.7 1.2 1 0 0 1 1 1 1 Tetraspanin family DUF5373 PF17343.2 EMC81638.1 - 0.012 15.5 0.6 0.016 15.0 0.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5373) DUF2981 PF11200.8 EMC81638.1 - 0.022 14.5 1.1 0.025 14.3 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) GAPT PF11770.8 EMC81638.1 - 3.2 7.6 6.7 0.67 9.8 1.8 2.2 1 1 1 2 2 2 0 GRB2-binding adapter (GAPT) Ac76 PF05814.11 EMC81638.1 - 3.4 7.7 8.6 10 6.2 8.6 1.7 1 1 0 1 1 1 0 Orf76 (Ac76) W2 PF02020.18 EMC81639.1 - 5.4e-21 74.5 9.0 7.9e-21 74.0 4.4 2.9 3 1 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon Ank_2 PF12796.7 EMC81640.1 - 1.7e-15 57.3 0.5 4.9e-12 46.3 0.2 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC81640.1 - 9.5e-13 48.4 0.5 1.8e-07 31.6 0.1 3.3 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC81640.1 - 1.5e-12 47.4 0.9 4.1e-09 36.5 0.2 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EMC81640.1 - 7e-11 42.1 0.2 6.8e-07 29.5 0.2 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 EMC81640.1 - 6.9e-10 38.3 0.3 2.6e-07 30.4 0.1 3.5 3 0 0 3 3 3 1 Ankyrin repeat zf-MYND PF01753.18 EMC81640.1 - 1.5e-09 37.8 13.2 1.5e-09 37.8 13.2 2.3 2 0 0 2 2 2 1 MYND finger PolC_DP2 PF03833.13 EMC81640.1 - 0.08 10.8 5.4 0.12 10.2 5.4 1.2 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-Mss51 PF13824.6 EMC81640.1 - 0.081 13.0 5.9 0.29 11.3 5.9 1.9 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 TraV PF09676.10 EMC81640.1 - 0.18 12.8 5.3 0.31 12.0 5.3 1.4 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) DUF2151 PF10221.9 EMC81640.1 - 0.45 9.0 7.7 0.7 8.4 7.7 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator MCM_bind PF09739.9 EMC81640.1 - 0.85 8.0 7.7 1.2 7.5 7.7 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Spore_coat_CotO PF14153.6 EMC81640.1 - 0.87 9.5 10.1 1.3 8.9 10.1 1.2 1 0 0 1 1 1 0 Spore coat protein CotO ATP-synt_E PF05680.12 EMC81640.1 - 1.3 9.4 6.2 2.6 8.4 6.2 1.5 1 0 0 1 1 1 0 ATP synthase E chain zf-C6H2 PF15801.5 EMC81640.1 - 5.5 7.4 19.2 0.87 9.9 12.4 2.4 2 0 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding LRR_9 PF14580.6 EMC81641.1 - 8.8e-18 64.4 3.8 2.2e-15 56.6 1.4 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 EMC81641.1 - 9.3e-15 54.5 9.6 4.1e-07 30.2 0.9 3.3 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMC81641.1 - 9.7e-05 22.1 21.3 0.0011 18.7 6.2 3.0 1 1 2 3 3 3 3 Leucine rich repeat LRR_6 PF13516.6 EMC81641.1 - 0.021 14.8 7.7 0.15 12.2 0.4 3.4 3 0 0 3 3 3 0 Leucine Rich repeat LRR_1 PF00560.33 EMC81641.1 - 0.33 11.7 11.0 12 7.0 0.7 4.7 3 1 1 4 4 4 0 Leucine Rich Repeat Sclerostin PF05463.11 EMC81642.1 - 7.7e-101 335.8 5.9 8.6e-101 335.7 5.9 1.0 1 0 0 1 1 1 1 Sclerostin (SOST) DAN PF03045.15 EMC81642.1 - 1.5e-14 54.0 1.9 2.1e-14 53.5 1.9 1.3 1 0 0 1 1 1 1 DAN domain Cys_knot PF00007.22 EMC81642.1 - 4.2e-05 23.8 7.6 0.00022 21.5 7.6 1.9 1 1 0 1 1 1 1 Cystine-knot domain MutS_V PF00488.21 EMC81646.1 - 1.9e-72 243.3 0.3 4.1e-72 242.2 0.3 1.6 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EMC81646.1 - 1.4e-33 116.8 1.6 4.8e-32 111.7 0.7 2.4 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.17 EMC81646.1 - 1.7e-19 70.5 0.2 4e-19 69.3 0.2 1.6 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 EMC81646.1 - 9.5e-17 61.1 0.0 2.3e-16 59.9 0.0 1.7 1 0 0 1 1 1 1 MutS family domain IV AAA_14 PF13173.6 EMC81646.1 - 2.2e-05 24.5 1.4 0.00077 19.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EMC81646.1 - 0.0029 17.3 0.0 0.0063 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 EMC81646.1 - 0.031 14.8 0.1 0.18 12.3 0.1 2.3 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EMC81646.1 - 0.051 13.5 0.5 0.54 10.1 0.5 2.5 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EMC81646.1 - 0.056 13.7 0.0 0.29 11.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EMC81646.1 - 0.14 12.0 0.0 0.37 10.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_27 PF13514.6 EMC81646.1 - 0.16 11.6 0.0 0.32 10.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain PRESAN PF09687.10 EMC81646.1 - 2.4 8.7 5.9 1.1 9.8 0.1 3.2 3 1 0 3 3 3 0 Plasmodium RESA N-terminal Glyco_transf_8 PF01501.20 EMC81647.1 - 1.4e-18 67.4 0.1 4.6e-16 59.1 0.1 2.5 2 1 0 2 2 2 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 EMC81647.1 - 0.0014 18.0 0.0 0.0021 17.5 0.0 1.3 1 0 0 1 1 1 1 Mannosyltransferase putative Nucleotid_trans PF03407.16 EMC81647.1 - 0.0095 15.9 0.1 0.02 14.9 0.1 1.5 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase SNF2_N PF00176.23 EMC81648.1 - 1.3e-81 274.1 0.0 1.8e-81 273.6 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 EMC81648.1 - 1.1e-19 70.2 0.0 2e-19 69.3 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 EMC81648.1 - 1.2e-13 51.3 0.0 8e-13 48.7 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4 PF00097.25 EMC81648.1 - 1.6e-07 31.1 12.0 4.1e-07 29.8 12.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMC81648.1 - 1.7e-07 31.0 10.2 4.8e-07 29.5 10.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC81648.1 - 4.2e-07 29.7 12.1 1.4e-06 28.0 12.1 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC81648.1 - 4.3e-06 26.6 11.6 1.4e-05 25.0 11.6 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMC81648.1 - 2.3e-05 24.2 11.2 2.3e-05 24.2 11.2 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 EMC81648.1 - 3.5e-05 24.1 11.9 3.5e-05 24.1 11.9 2.2 2 0 0 2 2 2 1 Ring finger domain zf-ANAPC11 PF12861.7 EMC81648.1 - 4.8e-05 23.3 1.5 0.00013 21.9 1.5 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EMC81648.1 - 0.00013 21.8 9.8 0.0003 20.6 9.8 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EMC81648.1 - 0.00048 20.2 12.6 0.0011 19.0 12.6 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EMC81648.1 - 0.0028 17.9 5.4 0.0094 16.2 5.4 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain ResIII PF04851.15 EMC81648.1 - 0.0049 16.9 0.0 3.4 7.7 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Prok-RING_1 PF14446.6 EMC81648.1 - 0.027 14.4 0.3 0.027 14.4 0.3 2.1 2 0 0 2 2 1 0 Prokaryotic RING finger family 1 zf-Nse PF11789.8 EMC81648.1 - 0.19 11.5 11.2 0.05 13.4 6.2 2.6 3 0 0 3 3 3 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_11 PF17123.5 EMC81648.1 - 1 9.1 9.2 2.8 7.8 9.2 1.8 1 0 0 1 1 1 0 RING-like zinc finger Tubulin PF00091.25 EMC81649.1 - 1.2e-67 228.0 0.0 1.6e-67 227.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EMC81649.1 - 1.8e-52 176.8 0.0 2.9e-52 176.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EMC81649.1 - 0.0014 18.3 0.0 0.0028 17.4 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Cu-oxidase_3 PF07732.15 EMC81650.1 - 8.2e-30 103.3 0.8 1e-09 38.4 0.0 5.9 4 1 0 4 4 4 4 Multicopper oxidase Cu-oxidase_2 PF07731.14 EMC81650.1 - 3.2e-28 98.2 14.0 5e-16 58.7 3.2 5.9 6 0 0 6 6 6 4 Multicopper oxidase Cu-oxidase PF00394.22 EMC81650.1 - 1.2e-12 48.2 0.2 1.5e-06 28.4 0.0 2.8 2 0 0 2 2 2 2 Multicopper oxidase Inhibitor_I78 PF11720.8 EMC81651.1 - 3.5e-16 59.0 0.2 20 5.3 0.0 10.8 1 1 17 18 18 18 9 Peptidase inhibitor I78 family Mucin-like PF16058.5 EMC81651.1 - 2.5e-15 56.4 5.3 0.0052 16.8 0.3 4.2 1 1 4 5 5 5 5 Mucin-like Ntox37 PF15535.6 EMC81651.1 - 8.8e-12 45.3 0.0 1.4 9.4 0.0 8.8 1 1 0 1 1 1 1 Bacterial toxin 37 DUF1560 PF07597.11 EMC81651.1 - 0.17 11.9 90.9 2.4e+02 1.8 0.1 26.3 29 0 0 29 29 29 0 Protein of unknown function (DUF1560) L6_membrane PF05805.12 EMC81652.1 - 1e-49 168.7 17.6 1.1e-49 168.6 17.6 1.0 1 0 0 1 1 1 1 L6 membrane protein DUF1616 PF07760.11 EMC81652.1 - 0.57 9.5 1.9 2 7.7 0.2 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1616) DUF5381 PF17353.2 EMC81652.1 - 8.3 6.1 7.3 8.4 6.1 2.5 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5381) L6_membrane PF05805.12 EMC81653.1 - 8.7e-67 224.4 16.4 9.8e-67 224.2 16.4 1.0 1 0 0 1 1 1 1 L6 membrane protein Yip1 PF04893.17 EMC81653.1 - 0.004 16.9 0.4 0.004 16.9 0.4 2.2 2 1 0 2 2 2 1 Yip1 domain DUF3273 PF11677.8 EMC81653.1 - 0.021 14.1 2.7 0.32 10.3 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3273) L6_membrane PF05805.12 EMC81654.1 - 2e-77 259.1 17.8 2.3e-77 258.9 17.8 1.0 1 0 0 1 1 1 1 L6 membrane protein PGF-CTERM PF18204.1 EMC81654.1 - 1.9 8.6 6.9 0.21 11.6 2.2 1.9 2 0 0 2 2 2 0 PGF-CTERM motif TFIIA PF03153.13 EMC81656.1 - 3.7 7.4 5.9 4 7.3 5.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit IL32 PF15225.6 EMC81657.1 - 0.45 10.9 2.8 6.2 7.2 0.0 3.0 1 1 2 3 3 3 0 Interleukin 32 Ykof PF07615.11 EMC81657.1 - 2.5 8.6 7.8 11 6.6 0.5 3.5 1 1 2 3 3 3 0 YKOF-related Family DUF220 PF02713.14 EMC81657.1 - 8.6 6.6 9.2 7.4 6.8 0.3 3.4 1 1 3 4 4 4 0 Domain of unknown function DUF220 COMM_domain PF07258.14 EMC81659.1 - 1.6e-18 66.6 1.1 1.6e-18 66.6 1.1 1.8 2 0 0 2 2 2 1 COMM domain HTH_1 PF00126.27 EMC81659.1 - 0.0039 17.1 0.3 0.055 13.4 0.1 2.1 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family DUF5057 PF16480.5 EMC81659.1 - 0.045 13.1 0.0 0.06 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5057) zf-RING_2 PF13639.6 EMC81660.1 - 3.2e-13 49.8 8.3 5.5e-13 49.0 8.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EMC81660.1 - 9e-12 44.5 3.9 9e-12 44.5 3.9 2.3 2 0 0 2 2 2 1 RING-like zinc finger PA PF02225.22 EMC81660.1 - 4e-09 36.4 0.0 9.5e-09 35.2 0.0 1.7 1 0 0 1 1 1 1 PA domain zf-C3HC4_2 PF13923.6 EMC81660.1 - 1.1e-08 34.8 8.9 1.9e-08 34.0 8.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC81660.1 - 1.8e-08 34.1 8.4 3.1e-08 33.3 8.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC81660.1 - 3.4e-06 26.9 6.9 5.5e-06 26.2 6.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EMC81660.1 - 3.9e-06 26.6 6.3 6.7e-06 25.9 6.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMC81660.1 - 4.4e-06 26.9 9.5 1.7e-05 25.0 9.5 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EMC81660.1 - 6.2e-05 22.9 4.4 0.00014 21.8 1.9 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EMC81660.1 - 0.0016 18.5 6.2 0.004 17.2 6.2 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EMC81660.1 - 0.0016 18.2 7.4 0.0038 17.0 7.1 1.7 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 FeoB_associated PF12669.7 EMC81660.1 - 0.059 13.8 1.2 0.16 12.4 1.2 1.7 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein DNA_ligase_ZBD PF03119.16 EMC81660.1 - 0.078 13.0 0.4 0.17 11.9 0.4 1.6 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain PHD PF00628.29 EMC81660.1 - 0.13 12.2 8.6 0.23 11.4 8.6 1.5 1 0 0 1 1 1 0 PHD-finger Baculo_11_kDa PF06143.11 EMC81660.1 - 0.15 11.7 1.4 2.3 7.9 0.3 2.9 3 0 0 3 3 3 0 Baculovirus 11 kDa family Zn_ribbon_17 PF17120.5 EMC81660.1 - 0.16 11.6 5.1 0.32 10.7 5.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Ninjurin PF04923.12 EMC81660.1 - 0.28 11.1 0.1 0.28 11.1 0.1 1.7 2 0 0 2 2 1 0 Ninjurin zf-RING_4 PF14570.6 EMC81660.1 - 0.31 10.9 8.7 0.65 9.8 8.7 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.7 EMC81660.1 - 1 9.6 7.4 2.3 8.4 7.4 1.6 1 0 0 1 1 1 0 RING-variant domain zf-C3H2C3 PF17122.5 EMC81660.1 - 5.2 7.2 9.3 15 5.7 9.3 1.8 1 1 0 1 1 1 0 Zinc-finger FANCL_C PF11793.8 EMC81660.1 - 6.7 7.0 8.9 54 4.1 8.9 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain Profilin PF00235.19 EMC81661.1 - 5.8e-13 49.2 0.0 6.1e-13 49.1 0.0 1.0 1 0 0 1 1 1 1 Profilin Pox_MCEL PF03291.16 EMC81662.1 - 1.2e-107 359.8 1.0 1.4e-107 359.7 1.0 1.0 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 EMC81662.1 - 5.5e-12 46.2 0.0 1.1e-11 45.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC81662.1 - 3.9e-11 43.0 0.1 6.5e-11 42.3 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC81662.1 - 1.4e-08 35.3 0.0 2.8e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC81662.1 - 9e-07 28.9 0.0 1.6e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC81662.1 - 1.5e-06 28.8 0.0 2.6e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EMC81662.1 - 0.0022 18.0 0.0 0.0037 17.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EMC81662.1 - 0.0033 17.3 0.1 0.0062 16.4 0.1 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase NNMT_PNMT_TEMT PF01234.17 EMC81662.1 - 0.014 14.6 0.0 0.022 13.9 0.0 1.3 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family MTS PF05175.14 EMC81662.1 - 0.014 14.9 0.0 0.037 13.6 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase small domain 7tm_1 PF00001.21 EMC81663.1 - 2.4e-37 128.7 38.2 9.9e-36 123.4 38.2 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC81663.1 - 6e-13 49.2 27.5 7.4e-11 42.3 22.9 2.9 1 1 1 2 2 2 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 EMC81663.1 - 9e-10 38.4 37.7 1.9e-09 37.3 37.7 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC81663.1 - 0.079 12.6 41.1 0.44 10.1 38.2 2.7 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.21 EMC81664.1 - 6.1e-33 114.3 25.6 3e-31 108.7 25.6 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC81664.1 - 6.8e-10 38.7 17.9 1.8e-07 30.8 17.9 2.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC81664.1 - 6.4e-08 32.7 18.3 1.4e-07 31.5 10.4 2.3 1 1 1 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC81664.1 - 6.8e-06 25.9 12.0 6.8e-06 25.9 12.0 2.9 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Ribosomal_60s PF00428.19 EMC81665.1 - 0.3 11.7 4.6 0.43 11.2 4.6 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein CKS PF01111.19 EMC81666.1 - 4.2e-29 100.6 1.9 4.6e-29 100.5 1.9 1.0 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit Ribosomal_L7Ae PF01248.26 EMC81667.1 - 2e-21 75.5 0.2 4.4e-21 74.4 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family AEP1 PF17049.5 EMC81668.1 - 0.041 13.0 0.2 0.044 12.8 0.2 1.0 1 0 0 1 1 1 0 ATPase expression protein 1 Uso1_p115_head PF04869.14 EMC81668.1 - 0.047 12.8 0.0 0.049 12.8 0.0 1.1 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, head region Sema PF01403.19 EMC81669.1 - 9.8e-158 525.4 0.0 1.4e-157 524.9 0.0 1.2 1 0 0 1 1 1 1 Sema domain PSI PF01437.25 EMC81669.1 - 2.8e-08 34.2 0.7 9.2e-08 32.5 0.7 1.9 1 0 0 1 1 1 1 Plexin repeat ig PF00047.25 EMC81669.1 - 1.1e-06 28.7 0.0 3.3e-06 27.2 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC81669.1 - 2.9e-06 27.8 0.0 0.0007 20.1 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 EMC81669.1 - 8.7e-05 22.5 0.1 0.0016 18.4 0.0 2.6 3 0 0 3 3 3 1 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC81669.1 - 0.00025 21.3 0.0 0.00081 19.7 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain Ig_5 PF16681.5 EMC81669.1 - 0.00026 21.3 1.1 0.00072 19.9 0.1 2.3 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Pkinase_fungal PF17667.1 EMC81669.1 - 0.12 11.1 0.0 0.24 10.1 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase PSI_integrin PF17205.3 EMC81669.1 - 0.53 10.1 3.4 0.63 9.8 1.5 2.2 2 0 0 2 2 2 0 Integrin plexin domain 7tm_4 PF13853.6 EMC81670.1 - 2.2e-37 129.3 8.7 1.2e-29 103.9 2.1 2.0 1 1 1 2 2 2 2 Olfactory receptor 7tm_1 PF00001.21 EMC81670.1 - 4.6e-19 68.8 6.0 2.3e-13 50.1 2.7 2.2 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) MFS_5 PF05631.14 EMC81671.1 - 5e-56 190.1 3.7 2.2e-34 118.9 1.3 2.0 1 1 1 2 2 2 2 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 EMC81671.1 - 8.3e-10 38.1 10.5 1.2e-08 34.3 1.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMC81671.1 - 0.00029 19.8 0.7 0.0006 18.8 0.7 1.5 1 0 0 1 1 1 1 Sugar (and other) transporter UNC-93 PF05978.16 EMC81671.1 - 0.0022 17.7 0.2 0.0049 16.6 0.2 1.5 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 MFS_2 PF13347.6 EMC81671.1 - 0.014 14.0 2.8 0.031 12.9 1.1 1.9 1 1 1 2 2 2 0 MFS/sugar transport protein MFS_1_like PF12832.7 EMC81671.1 - 0.014 14.3 0.9 0.073 11.9 0.9 2.1 1 1 1 2 2 2 0 MFS_1 like family DoxX_3 PF13781.6 EMC81671.1 - 0.22 12.2 2.4 1.1 10.0 0.2 2.6 2 0 0 2 2 2 0 DoxX-like family PDZ PF00595.24 EMC81673.1 - 2.6e-66 220.0 5.4 4.8e-14 52.5 0.1 5.5 5 0 0 5 5 5 5 PDZ domain PDZ_6 PF17820.1 EMC81673.1 - 3.9e-50 167.5 9.9 4.4e-12 45.6 0.0 5.5 5 0 0 5 5 5 5 PDZ domain MAGI_u5 PF16666.5 EMC81673.1 - 1.6e-41 141.5 6.7 1.6e-41 141.5 6.7 4.1 5 0 0 5 5 5 1 Unstructured region on MAGI PDZ_2 PF13180.6 EMC81673.1 - 2.6e-30 104.6 0.0 2.5e-05 24.5 0.0 5.8 6 0 0 6 6 6 5 PDZ domain MAGI_u1 PF16663.5 EMC81673.1 - 2.1e-28 98.2 3.5 7.6e-28 96.4 3.5 2.1 1 0 0 1 1 1 1 Unstructured region on MAGI WW PF00397.26 EMC81673.1 - 2e-18 66.2 3.8 7.4e-10 38.7 0.4 2.6 2 0 0 2 2 2 2 WW domain Guanylate_kin PF00625.21 EMC81673.1 - 1.4e-09 37.9 0.0 2.9e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 Guanylate kinase Tricorn_PDZ PF14685.6 EMC81673.1 - 1.6e-08 34.4 6.3 0.1 12.6 0.0 5.1 5 0 0 5 5 5 3 Tricorn protease PDZ domain PDZ_4 PF17816.1 EMC81673.1 - 0.00048 20.5 0.0 10 6.5 0.0 3.9 4 0 0 4 4 4 1 PDZ domain Serglycin PF04360.12 EMC81673.1 - 0.065 13.2 0.3 0.17 11.8 0.3 1.7 1 0 0 1 1 1 0 Serglycin GRASP55_65 PF04495.14 EMC81673.1 - 0.17 12.2 0.0 5.3 7.4 0.0 2.6 3 0 0 3 3 2 0 GRASP55/65 PDZ-like domain GON PF08685.11 EMC81674.1 - 2.2e-82 275.8 1.1 2.2e-82 275.8 1.1 2.5 2 0 0 2 2 2 1 GON domain TSP_1 PF00090.19 EMC81674.1 - 1.3e-61 204.5 207.0 2e-07 31.1 5.9 17.3 17 1 0 17 17 16 14 Thrombospondin type 1 domain ADAM_spacer1 PF05986.14 EMC81674.1 - 1.4e-32 112.1 0.1 2.5e-32 111.3 0.1 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Reprolysin PF01421.19 EMC81674.1 - 4.3e-27 95.3 0.3 7.9e-27 94.5 0.3 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR_2 PF17771.1 EMC81674.1 - 2.2e-19 69.7 12.2 4.5e-18 65.5 6.8 11.1 10 2 0 10 10 5 2 ADAM cysteine-rich domain Reprolysin_5 PF13688.6 EMC81674.1 - 1.2e-15 58.2 1.8 3.3e-15 56.8 1.8 1.8 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EMC81674.1 - 2.6e-10 40.9 0.3 6.7e-10 39.5 0.3 1.8 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EMC81674.1 - 2.4e-09 37.4 0.5 5.4e-09 36.2 0.5 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Pep_M12B_propep PF01562.19 EMC81674.1 - 0.00014 22.1 0.2 0.00085 19.6 0.1 2.4 2 0 0 2 2 2 1 Reprolysin family propeptide Reprolysin_4 PF13583.6 EMC81674.1 - 0.0062 16.2 0.2 0.013 15.2 0.2 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M78 PF06114.13 EMC81674.1 - 0.17 11.8 0.1 0.32 10.9 0.1 1.4 1 0 0 1 1 1 0 IrrE N-terminal-like domain RPN7 PF10602.9 EMC81675.1 - 6.2e-63 211.6 2.6 9.1e-63 211.1 2.6 1.3 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EMC81675.1 - 3.4e-18 66.1 0.2 9.5e-18 64.6 0.0 1.9 2 0 0 2 2 2 1 PCI domain RPW8 PF05659.11 EMC81675.1 - 0.019 14.6 2.3 1.7 8.3 0.2 3.2 3 0 0 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF1732 PF08340.11 EMC81675.1 - 0.045 13.7 1.8 6 6.9 0.6 3.3 2 2 1 3 3 3 0 Domain of unknown function (DUF1732) SCA7 PF08313.12 EMC81676.1 - 5.4e-26 90.3 1.9 5.4e-26 90.3 1.9 2.4 2 0 0 2 2 2 1 SCA7, zinc-binding domain OrsD PF12013.8 EMC81676.1 - 0.14 12.6 0.1 0.14 12.6 0.1 2.8 3 0 0 3 3 3 0 Orsellinic acid/F9775 biosynthesis cluster protein D THOC7 PF05615.13 EMC81677.1 - 6.3e-40 136.5 9.4 9.4e-40 136.0 0.8 2.1 1 1 1 2 2 2 1 Tho complex subunit 7 UPF0193 PF05250.11 EMC81677.1 - 0.0011 18.8 5.2 0.0011 18.8 5.2 1.5 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0193) COG2 PF06148.11 EMC81677.1 - 0.24 11.5 10.9 0.062 13.4 1.3 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Spc7 PF08317.11 EMC81677.1 - 0.29 10.0 18.5 0.059 12.2 3.1 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein NPV_P10 PF05531.12 EMC81677.1 - 0.75 10.3 3.3 8.3 7.0 2.6 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF4407 PF14362.6 EMC81677.1 - 1.7 7.9 8.7 0.083 12.2 2.0 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF16 PF01519.16 EMC81677.1 - 2.7 8.5 13.8 0.2 12.2 3.1 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF16 EP400_N PF15790.5 EMC81677.1 - 3.8 6.2 7.3 4.9 5.9 7.3 1.2 1 0 0 1 1 1 0 E1A-binding protein p400, N-terminal AATF-Che1 PF13339.6 EMC81677.1 - 4.2 8.0 13.9 2.5 8.8 6.5 2.2 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor V_ATPase_I PF01496.19 EMC81677.1 - 4.3 5.1 12.9 5.3 4.8 12.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Med9 PF07544.13 EMC81677.1 - 4.5 7.4 18.8 0.47 10.6 1.6 3.2 1 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 DUF1664 PF07889.12 EMC81677.1 - 5.1 7.1 9.2 20 5.3 3.3 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) S_100 PF01023.19 EMC81678.1 - 0.00015 21.4 0.0 0.00048 19.8 0.0 1.9 2 0 0 2 2 2 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.6 EMC81678.1 - 0.012 16.0 0.2 0.022 15.2 0.2 1.3 1 0 0 1 1 1 0 EF-hand domain pair MARVEL PF01284.23 EMC81679.1 - 1e-43 148.8 6.6 1.3e-43 148.4 6.6 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF588 PF04535.12 EMC81679.1 - 0.0025 17.6 1.7 0.0025 17.6 1.7 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF588) ECF_trnsprt PF12822.7 EMC81679.1 - 0.013 15.6 0.8 0.053 13.6 0.8 1.8 1 1 0 1 1 1 0 ECF transporter, substrate-specific component Frizzled PF01534.17 EMC81679.1 - 0.039 13.0 5.7 0.36 9.8 5.7 2.1 1 1 0 1 1 1 0 Frizzled/Smoothened family membrane region DUF3278 PF11683.8 EMC81679.1 - 0.11 12.5 1.6 0.3 11.2 1.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3278) DUF1129 PF06570.11 EMC81679.1 - 0.34 10.4 1.6 0.27 10.7 0.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Pilosulin PF17499.2 EMC81681.1 - 0.0062 16.7 3.0 25 5.1 0.1 4.5 1 1 3 4 4 4 3 Ant venom peptides Collagen PF01391.18 EMC81682.1 - 0.032 14.0 2.0 0.088 12.6 2.0 1.8 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) HSNSD PF12062.8 EMC81683.1 - 1.4e-249 828.9 0.1 1.8e-249 828.4 0.1 1.2 1 0 0 1 1 1 1 heparan sulfate-N-deacetylase Sulfotransfer_1 PF00685.27 EMC81683.1 - 9.4e-43 146.6 0.0 1.6e-42 145.9 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC81683.1 - 2.2e-08 34.7 0.2 0.0011 19.4 0.0 2.4 1 1 1 2 2 2 2 Sulfotransferase family SRCR PF00530.18 EMC81684.1 - 5.8e-119 389.4 34.2 1.6e-32 111.9 5.0 4.6 5 0 0 5 5 5 4 Scavenger receptor cysteine-rich domain Trypsin PF00089.26 EMC81684.1 - 2.4e-66 223.7 0.1 4.1e-66 223.0 0.1 1.4 1 0 0 1 1 1 1 Trypsin SRCR_2 PF15494.6 EMC81684.1 - 3.4e-23 82.0 17.8 4.1e-06 27.2 1.6 4.8 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 EMC81684.1 - 3.3e-09 37.2 0.2 1.2 9.7 0.0 4.6 4 0 0 4 4 4 3 Hepsin, SRCR domain DUF1986 PF09342.11 EMC81684.1 - 0.00048 20.5 0.0 0.00096 19.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) HMG_CoA_synt_N PF01154.17 EMC81684.1 - 0.33 10.8 2.3 8.4 6.2 0.0 2.7 3 0 0 3 3 3 0 Hydroxymethylglutaryl-coenzyme A synthase N terminal MT-A70 PF05063.14 EMC81685.1 - 2.8e-63 212.9 0.0 3.9e-63 212.4 0.0 1.2 1 0 0 1 1 1 1 MT-A70 Sec23_trunk PF04811.15 EMC81686.1 - 9.4e-85 284.1 0.1 1.5e-84 283.4 0.1 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EMC81686.1 - 6.5e-24 83.7 0.2 1.3e-23 82.8 0.2 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EMC81686.1 - 1.4e-17 64.2 0.0 3.3e-17 63.0 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EMC81686.1 - 1.9e-13 50.2 10.3 4.8e-13 48.9 10.3 1.8 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EMC81686.1 - 6.6e-07 29.2 0.0 1.5e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat GDP_Man_Dehyd PF16363.5 EMC81686.1 - 0.052 12.9 0.0 0.083 12.3 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Transp_Tc5_C PF04236.15 EMC81686.1 - 0.55 10.6 3.9 1.8 9.0 0.0 3.5 4 0 0 4 4 4 0 Tc5 transposase C-terminal domain PDZ_6 PF17820.1 EMC81687.1 - 1e-07 31.7 0.0 2e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 EMC81687.1 - 1.8e-05 25.0 0.0 3.8e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Calsarcin PF05556.11 EMC81687.1 - 0.0005 19.7 9.0 0.15 11.5 0.1 3.1 2 1 0 2 2 2 2 Calcineurin-binding protein (Calsarcin) PDZ_2 PF13180.6 EMC81687.1 - 0.016 15.5 0.0 0.045 14.1 0.0 1.8 1 0 0 1 1 1 0 PDZ domain Calsarcin PF05556.11 EMC81688.1 - 1.3e-84 283.7 0.6 3.6e-84 282.3 0.6 1.6 1 1 0 1 1 1 1 Calcineurin-binding protein (Calsarcin) UCH PF00443.29 EMC81689.1 - 4.9e-20 72.1 0.3 4.9e-20 72.1 0.3 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMC81689.1 - 2.5e-08 33.9 5.5 2.5e-08 33.9 5.5 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Lipocalin PF00061.23 EMC81690.1 - 1.2e-15 57.9 1.2 1.4e-15 57.7 1.2 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 EMC81690.1 - 3.1e-12 46.5 1.1 3.7e-12 46.3 1.1 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_4 PF13648.6 EMC81690.1 - 0.014 16.4 4.4 0.031 15.2 4.4 1.6 1 1 0 1 1 1 0 Lipocalin-like domain PDEase_I PF00233.19 EMC81691.1 - 5.6e-76 255.4 1.6 5.6e-76 255.4 1.6 2.3 2 1 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.26 EMC81691.1 - 9.8e-33 113.6 0.0 3.6e-15 56.8 0.0 2.6 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.6 EMC81691.1 - 1.5e-07 31.8 0.0 0.0042 17.4 0.0 2.5 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.6 EMC81691.1 - 3.8e-05 24.1 0.1 5.4 7.4 0.0 4.5 4 2 0 4 4 4 2 GAF domain UTP15_C PF09384.10 EMC81691.1 - 0.012 15.3 0.3 0.79 9.4 0.1 2.8 2 0 0 2 2 2 0 UTP15 C terminal ATLF PF07737.11 EMC81691.1 - 0.093 12.0 2.5 0.12 11.6 1.2 1.9 2 0 0 2 2 2 0 Anthrax toxin lethal factor, N- and C-terminal domain zf_ZIC PF18366.1 EMC81691.1 - 0.26 11.4 2.6 41 4.4 0.2 3.7 3 1 1 4 4 4 0 Zic proteins zinc finger domain Ribosomal_L30_N PF08079.12 EMC81692.1 - 2.3e-22 79.0 7.0 2.3e-22 79.0 7.0 1.9 2 0 0 2 2 2 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 EMC81692.1 - 7e-14 51.4 1.3 7e-14 51.4 1.3 2.3 3 0 0 3 3 3 1 Ribosomal protein L30p/L7e HORMA PF02301.18 EMC81693.1 - 2.7e-22 79.4 0.3 4.1e-22 78.8 0.3 1.3 1 0 0 1 1 1 1 HORMA domain ATG101 PF07855.12 EMC81693.1 - 7.9e-05 22.7 0.3 0.0012 18.8 0.3 2.1 1 1 0 1 1 1 1 Autophagy-related protein 101 zf-H2C2_2 PF13465.6 EMC81694.1 - 2.5e-71 233.1 117.5 2.3e-10 40.4 0.6 16.8 17 0 0 17 17 17 13 Zinc-finger double domain zf-C2H2 PF00096.26 EMC81694.1 - 7.9e-71 230.8 111.7 1.6e-06 28.2 0.6 16.2 16 0 0 16 16 16 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC81694.1 - 9.9e-59 190.9 113.5 0.00018 22.1 0.2 16.2 16 0 0 16 16 16 16 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC81694.1 - 1.4e-34 117.7 98.1 7.6e-06 26.1 1.2 16.2 16 0 0 16 16 16 10 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC81694.1 - 7.7e-31 105.6 92.8 3.4e-05 24.1 2.4 15.7 16 0 0 16 16 16 9 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EMC81694.1 - 1.5e-27 95.0 106.6 0.001 19.0 0.6 16.7 15 2 1 16 16 16 11 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EMC81694.1 - 5.2e-19 67.7 61.2 0.0036 17.0 0.1 14.1 15 0 0 15 15 15 7 zinc-finger C2H2-type zf-Di19 PF05605.12 EMC81694.1 - 8.5e-11 42.0 80.6 0.003 17.8 1.9 9.4 5 3 3 9 9 9 7 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.5 EMC81694.1 - 1.5e-05 25.2 66.4 0.00054 20.2 2.1 8.7 1 1 7 9 9 9 2 C2H2-type zinc ribbon zf-H2C2_5 PF13909.6 EMC81694.1 - 3.6e-05 23.4 5.3 0.0026 17.5 0.3 14.6 15 2 0 15 15 14 3 C2H2-type zinc-finger domain Trm112p PF03966.16 EMC81694.1 - 0.00042 20.8 11.1 0.082 13.5 0.1 5.5 3 2 1 4 4 3 1 Trm112p-like protein zf_UBZ PF18439.1 EMC81694.1 - 0.00092 18.8 69.7 0.2 11.3 0.2 14.8 16 0 0 16 16 16 2 Ubiquitin-Binding Zinc Finger zf-C2H2_3rep PF18868.1 EMC81694.1 - 0.0049 17.6 8.6 0.0049 17.6 8.6 7.9 1 1 5 6 6 6 1 Zinc finger C2H2-type, 3 repeats BolA PF01722.18 EMC81694.1 - 0.0068 16.7 23.2 5.5 7.3 0.1 7.4 4 3 3 7 7 7 1 BolA-like protein zf-C2H2_2 PF12756.7 EMC81694.1 - 0.0085 16.4 92.6 4.4 7.7 1.0 13.4 1 1 8 11 11 10 3 C2H2 type zinc-finger (2 copies) zf_C2H2_10 PF18414.1 EMC81694.1 - 0.092 12.3 12.0 2.5 7.7 0.0 5.6 5 0 0 5 5 5 0 C2H2 type zinc-finger FerB PF08150.12 EMC81694.1 - 0.22 12.1 0.6 2.4 8.8 0.3 2.9 1 1 1 2 2 2 0 FerB (NUC096) domain TRAF6_Z2 PF18048.1 EMC81694.1 - 0.39 10.9 0.1 0.39 10.9 0.1 7.6 9 0 0 9 9 8 0 TNF receptor-associated factor 6 zinc finger 2 zinc_ribbon_15 PF17032.5 EMC81694.1 - 0.51 11.1 76.1 1.2 9.9 2.1 8.8 2 1 6 9 9 9 0 zinc-ribbon family zinc_ribbon_9 PF14369.6 EMC81694.1 - 0.66 10.3 46.6 3.5 8.0 0.1 11.4 12 1 0 12 12 11 0 zinc-ribbon Zn-ribbon_8 PF09723.10 EMC81694.1 - 2.5 8.3 82.4 0.2 11.8 1.5 11.6 8 3 5 13 13 13 0 Zinc ribbon domain zf-C2HC_2 PF13913.6 EMC81694.1 - 6.4 6.8 69.8 0.1 12.6 2.5 12.6 14 0 0 14 14 12 0 zinc-finger of a C2HC-type DUF2369 PF10179.9 EMC81695.1 - 3.6e-36 123.4 1.6 2.7e-30 104.6 0.7 3.2 3 0 0 3 3 3 2 Uncharacterised conserved protein (DUF2369) fn3 PF00041.21 EMC81695.1 - 4.7e-09 36.5 1.1 0.0047 17.2 0.0 4.0 3 1 0 3 3 3 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 EMC81695.1 - 6.8e-06 26.6 0.6 0.2 12.3 0.0 2.8 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain CC2-LZ PF16516.5 EMC81696.1 - 2.8e-12 46.9 18.4 2.8e-12 46.9 18.4 3.4 1 1 2 3 3 3 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator KxDL PF10241.9 EMC81696.1 - 0.00018 21.7 3.8 0.00018 21.7 3.8 3.7 3 1 1 4 4 4 2 Uncharacterized conserved protein HAUS-augmin3 PF14932.6 EMC81696.1 - 0.21 11.2 29.9 0.054 13.1 7.3 3.1 1 1 2 3 3 3 0 HAUS augmin-like complex subunit 3 TPR_MLP1_2 PF07926.12 EMC81696.1 - 0.25 11.4 33.5 0.33 11.0 5.9 3.3 2 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 EMC81696.1 - 0.35 10.2 15.7 43 3.3 15.7 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) YabA PF06156.13 EMC81696.1 - 8.5 7.1 32.0 2.1 9.0 4.8 3.8 1 1 3 4 4 4 0 Initiation control protein YabA DUF4061 PF13270.6 EMC81696.1 - 8.6 6.8 18.6 0.052 13.9 4.2 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4061) 7tm_1 PF00001.21 EMC81697.1 - 1.5e-39 135.9 18.5 2.4e-39 135.3 18.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC81697.1 - 0.00016 21.1 2.9 0.00016 21.1 2.9 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 EMC81697.1 - 0.011 15.0 19.6 0.21 10.8 3.0 2.2 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.6 EMC81697.1 - 0.016 15.0 2.3 0.016 15.0 2.3 3.0 2 1 0 2 2 2 0 Olfactory receptor Herpes_US9 PF06072.11 EMC81697.1 - 0.018 14.9 0.5 0.018 14.9 0.5 2.9 4 0 0 4 4 4 0 Alphaherpesvirus tegument protein US9 T4SS_CagC PF16943.5 EMC81697.1 - 0.23 11.7 0.1 0.23 11.7 0.1 2.7 3 0 0 3 3 3 0 Cag pathogenicity island, type IV secretory system MatE PF01554.18 EMC81697.1 - 9.3 5.9 18.3 0.19 11.4 3.0 3.2 3 1 0 3 3 3 0 MatE Annexin PF00191.20 EMC81698.1 - 5.5e-98 321.1 9.5 4e-25 87.7 0.2 4.0 4 0 0 4 4 4 4 Annexin DUF5069 PF16798.5 EMC81698.1 - 0.013 15.7 0.0 5.3 7.3 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5069) DNA_processg_A PF02481.15 EMC81698.1 - 0.16 11.2 0.1 2.6 7.2 0.0 2.4 2 1 1 3 3 3 0 DNA recombination-mediator protein A RNase_PH PF01138.21 EMC81699.1 - 1.4e-15 58.0 0.0 3.1e-15 56.9 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EMC81699.1 - 1.1e-10 41.3 0.0 3.2e-10 39.9 0.0 1.8 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Cyclin_N PF00134.23 EMC81700.1 - 1.2e-49 167.3 0.2 2.2e-49 166.4 0.2 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EMC81700.1 - 1.3e-29 102.7 1.8 3.4e-29 101.3 0.5 2.0 2 0 0 2 2 2 1 Cyclin, C-terminal domain BBS2_C PF14782.6 EMC81701.1 - 7.9e-05 21.6 0.6 0.0002 20.3 0.6 1.6 1 1 0 1 1 1 1 Ciliary BBSome complex subunit 2, C-terminal FlxA PF14282.6 EMC81701.1 - 0.0013 18.7 0.4 0.0028 17.6 0.4 1.4 1 0 0 1 1 1 1 FlxA-like protein BBS2_Mid PF14783.6 EMC81701.1 - 0.004 17.2 0.0 0.013 15.5 0.0 2.0 1 1 0 1 1 1 1 Ciliary BBSome complex subunit 2, middle region AKNA PF12443.8 EMC81701.1 - 0.051 14.2 0.3 0.12 13.0 0.3 1.6 1 0 0 1 1 1 0 AT-hook-containing transcription factor ZapB PF06005.12 EMC81701.1 - 1.3 9.5 6.1 7.8 7.0 1.4 2.5 2 0 0 2 2 2 0 Cell division protein ZapB Jnk-SapK_ap_N PF09744.9 EMC81701.1 - 1.6 8.9 7.0 11 6.2 2.0 2.9 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 Ion_trans PF00520.31 EMC81702.1 - 9e-33 113.5 17.0 1.4e-32 112.9 16.8 1.4 1 1 0 1 1 1 1 Ion transport protein TRP_2 PF08344.11 EMC81702.1 - 1.5e-27 95.6 1.1 1.5e-27 95.6 1.1 2.0 2 0 0 2 2 2 1 Transient receptor ion channel II PKD_channel PF08016.12 EMC81702.1 - 2.4e-14 52.8 10.3 3.9e-14 52.2 10.3 1.3 1 0 0 1 1 1 1 Polycystin cation channel Ank_2 PF12796.7 EMC81702.1 - 3.1e-11 43.7 0.1 5.3e-08 33.3 0.2 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC81702.1 - 1.8e-07 31.6 0.1 0.0025 18.4 0.0 3.3 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC81702.1 - 9.8e-07 28.9 0.6 1 9.7 0.0 4.4 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC81702.1 - 1.3e-06 28.3 3.5 1.8 9.4 0.0 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 EMC81702.1 - 0.00029 21.2 0.4 2.5 8.7 0.0 3.7 3 0 0 3 3 3 1 Ankyrin repeat ING PF12998.7 EMC81702.1 - 0.058 14.0 6.4 1.8 9.2 3.0 2.5 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding A_deamin PF02137.18 EMC81703.1 - 5e-88 295.7 0.2 6.6e-88 295.3 0.2 1.2 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain dsrm PF00035.26 EMC81703.1 - 9.4e-13 48.7 0.1 1.1e-11 45.2 0.0 2.7 3 0 0 3 3 3 1 Double-stranded RNA binding motif IL15 PF02372.15 EMC81704.1 - 1.2e-34 119.2 7.2 1.7e-33 115.5 7.2 2.0 1 1 0 1 1 1 1 Interleukin 15 CFAP91 PF14738.6 EMC81704.1 - 0.014 15.5 0.2 0.017 15.2 0.2 1.2 1 0 0 1 1 1 0 Cilia- and flagella-associated protein 91 DNA_pack_N PF02500.15 EMC81704.1 - 0.065 13.0 0.4 0.084 12.7 0.4 1.2 1 0 0 1 1 1 0 Probable DNA packing protein, N-terminus IL15 PF02372.15 EMC81705.1 - 3.2e-13 49.8 2.0 4.4e-13 49.4 2.0 1.2 1 0 0 1 1 1 1 Interleukin 15 EF-hand_1 PF00036.32 EMC81706.1 - 2e-34 114.6 17.4 7.5e-09 34.5 0.1 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EMC81706.1 - 4.3e-31 107.2 9.1 1.1e-15 57.8 0.5 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EMC81706.1 - 2.3e-27 92.5 10.7 4.6e-09 35.5 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EMC81706.1 - 1.5e-25 88.8 16.9 6.2e-12 45.2 0.6 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 EMC81706.1 - 3.4e-16 57.9 18.2 1.1e-05 24.7 0.2 4.6 4 1 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 EMC81706.1 - 7.8e-16 58.2 0.3 5.1e-07 29.9 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EMC81706.1 - 5.7e-06 26.2 7.8 0.3 11.1 0.1 3.3 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 EMC81706.1 - 0.00019 21.7 1.3 0.63 10.4 0.2 2.4 1 1 1 2 2 2 2 EF-hand domain SurA_N_3 PF13624.6 EMC81706.1 - 0.00064 19.6 3.2 0.14 11.9 0.4 2.1 1 1 0 2 2 2 2 SurA N-terminal domain DUF853 PF05872.12 EMC81706.1 - 0.00076 18.2 0.3 0.72 8.4 0.1 2.1 1 1 1 2 2 2 2 Bacterial protein of unknown function (DUF853) SPARC_Ca_bdg PF10591.9 EMC81706.1 - 0.0012 19.1 0.7 0.28 11.5 0.3 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 EMC81706.1 - 0.0039 17.4 0.3 0.35 11.1 0.2 2.7 1 1 1 2 2 2 1 Dockerin type I domain DUF3349 PF11829.8 EMC81706.1 - 0.0098 16.7 2.4 2.6 8.9 0.1 3.0 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) Sigma54_CBD PF04963.13 EMC81706.1 - 0.019 14.8 0.3 0.027 14.4 0.3 1.2 1 0 0 1 1 1 0 Sigma-54 factor, core binding domain TerB PF05099.13 EMC81706.1 - 0.023 14.6 3.3 0.29 11.1 0.1 2.7 1 1 2 3 3 3 0 Tellurite resistance protein TerB SUB1_ProdP9 PF18213.1 EMC81706.1 - 0.026 14.4 1.3 0.037 13.9 0.3 1.8 1 1 1 2 2 2 0 SUB1 protease Prodomain ProdP9 SurA_N_2 PF13623.6 EMC81706.1 - 0.036 13.9 3.2 0.67 9.8 0.5 2.6 1 1 1 2 2 2 0 SurA N-terminal domain EF-hand_11 PF08976.11 EMC81706.1 - 0.048 14.5 0.1 8.5 7.3 0.0 2.1 1 1 1 2 2 2 0 EF-hand domain PB1 PF00564.24 EMC81706.1 - 0.066 13.2 0.5 4.6 7.3 0.2 2.5 2 0 0 2 2 2 0 PB1 domain DUF4601 PF15373.6 EMC81706.1 - 0.071 12.1 0.1 0.12 11.3 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4601) PMBR PF09373.10 EMC81706.1 - 0.083 13.1 0.5 70 3.8 0.0 4.2 5 0 0 5 5 5 0 Pseudomurein-binding repeat LETM1 PF07766.13 EMC81706.1 - 0.085 12.2 2.4 0.24 10.7 0.6 2.3 1 1 1 2 2 2 0 LETM1-like protein Caleosin PF05042.13 EMC81706.1 - 0.093 12.7 1.6 9.9 6.1 0.0 3.3 1 1 3 4 4 4 0 Caleosin related protein DUF1542 PF07564.11 EMC81706.1 - 0.41 10.8 3.4 21 5.3 0.1 2.8 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1542) SRI PF08236.11 EMC81706.1 - 0.56 10.4 4.9 1 9.6 0.1 3.1 2 1 1 3 3 3 0 SRI (Set2 Rpb1 interacting) domain Gp-FAR-1 PF05823.12 EMC81706.1 - 1.5 9.2 6.7 1.5 9.2 0.2 2.9 2 1 0 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Cpn60_TCP1 PF00118.24 EMC81707.1 - 1.4e-20 73.4 0.0 6.1e-12 44.9 0.0 2.1 2 0 0 2 2 2 2 TCP-1/cpn60 chaperonin family DUF5584 PF17822.1 EMC81707.1 - 0.14 11.6 0.1 0.29 10.6 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5584) FGF PF00167.18 EMC81708.1 - 1.3e-27 96.4 0.0 1.5e-27 96.2 0.0 1.0 1 0 0 1 1 1 1 Fibroblast growth factor IL1 PF00340.19 EMC81708.1 - 0.00045 19.9 0.0 0.00053 19.6 0.0 1.2 1 0 0 1 1 1 1 Interleukin-1 / 18 Glyco_transf_15 PF01793.16 EMC81708.1 - 0.071 12.4 0.1 0.072 12.3 0.1 1.0 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase NUDIX PF00293.28 EMC81709.1 - 2.4e-19 69.7 0.0 2.9e-19 69.4 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain AAA PF00004.29 EMC81710.1 - 2e-71 238.6 0.0 3.2e-43 147.3 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EMC81710.1 - 3.6e-15 56.1 0.0 6.3e-08 32.5 0.0 3.0 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EMC81710.1 - 1.1e-11 44.9 0.0 6.4e-05 23.0 0.0 3.1 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 EMC81710.1 - 3.8e-10 39.4 0.6 1.2e-09 37.9 0.6 1.8 1 0 0 1 1 1 1 AAA+ lid domain TIP49 PF06068.13 EMC81710.1 - 4.8e-10 39.2 0.2 9.9e-05 21.7 0.0 2.7 3 0 0 3 3 3 2 TIP49 P-loop domain AAA_16 PF13191.6 EMC81710.1 - 2e-08 34.8 6.3 0.00085 19.7 0.0 4.4 4 2 1 6 6 5 2 AAA ATPase domain AAA_22 PF13401.6 EMC81710.1 - 6.4e-08 33.0 1.0 0.015 15.6 0.1 4.4 3 2 1 4 4 4 1 AAA domain AAA_2 PF07724.14 EMC81710.1 - 8.4e-08 32.5 0.0 0.0007 19.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 EMC81710.1 - 2.4e-07 30.4 0.9 0.0053 16.2 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EMC81710.1 - 2.9e-07 30.4 0.0 0.0051 16.6 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_33 PF13671.6 EMC81710.1 - 6.6e-07 29.6 0.0 0.0047 17.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 EMC81710.1 - 1.4e-06 28.6 0.0 0.0073 16.7 0.0 2.4 2 0 0 2 2 2 2 RNA helicase Rad17 PF03215.15 EMC81710.1 - 7.5e-06 26.0 0.1 0.021 14.8 0.0 3.1 3 1 0 3 3 2 1 Rad17 P-loop domain Parvo_NS1 PF01057.17 EMC81710.1 - 9.3e-06 24.9 0.1 0.0074 15.4 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 EMC81710.1 - 1e-05 25.2 0.2 0.3 10.6 0.1 3.3 2 1 0 3 3 3 2 AAA domain AAA_28 PF13521.6 EMC81710.1 - 1.1e-05 25.7 0.0 0.032 14.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 EMC81710.1 - 1.2e-05 25.3 0.0 0.047 13.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain Sigma54_activ_2 PF14532.6 EMC81710.1 - 1.3e-05 25.4 0.0 0.063 13.4 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain TsaE PF02367.17 EMC81710.1 - 1.6e-05 24.9 0.0 0.069 13.2 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EMC81710.1 - 1.7e-05 24.4 0.1 0.086 12.3 0.0 2.8 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_18 PF13238.6 EMC81710.1 - 2.2e-05 25.0 0.0 0.013 16.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.11 EMC81710.1 - 6.3e-05 22.8 0.0 0.41 10.5 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EMC81710.1 - 0.00063 19.5 0.0 0.29 10.8 0.0 2.9 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_24 PF13479.6 EMC81710.1 - 0.00074 19.3 0.0 0.044 13.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain CDC48_N PF02359.18 EMC81710.1 - 0.0008 19.5 0.0 0.0017 18.5 0.0 1.5 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain ABC_tran PF00005.27 EMC81710.1 - 0.00086 19.8 0.1 0.94 10.0 0.0 2.9 2 1 1 3 3 3 1 ABC transporter NACHT PF05729.12 EMC81710.1 - 0.001 19.0 0.4 0.17 11.8 0.1 2.8 3 0 0 3 3 3 1 NACHT domain ATPase PF06745.13 EMC81710.1 - 0.0032 16.9 0.1 0.66 9.3 0.0 2.4 2 0 0 2 2 2 1 KaiC DUF815 PF05673.13 EMC81710.1 - 0.0033 16.6 0.0 0.54 9.4 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_17 PF13207.6 EMC81710.1 - 0.0036 17.7 0.0 1 9.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EMC81710.1 - 0.0041 16.9 0.0 0.04 13.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EMC81710.1 - 0.0048 16.7 0.0 0.91 9.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EMC81710.1 - 0.0057 16.0 0.2 1.1 8.5 0.1 2.3 2 0 0 2 2 2 1 Zeta toxin TniB PF05621.11 EMC81710.1 - 0.013 15.0 0.1 1.5 8.2 0.0 3.4 4 0 0 4 4 3 0 Bacterial TniB protein CDC48_2 PF02933.17 EMC81710.1 - 0.021 14.6 0.1 0.13 12.0 0.0 2.4 2 1 1 3 3 3 0 Cell division protein 48 (CDC48), domain 2 AAA_19 PF13245.6 EMC81710.1 - 0.027 14.8 0.6 0.57 10.5 0.2 2.5 2 1 0 2 2 2 0 AAA domain IPT PF01745.16 EMC81710.1 - 0.041 13.3 0.1 1.1 8.6 0.1 2.2 2 0 0 2 2 2 0 Isopentenyl transferase PhoH PF02562.16 EMC81710.1 - 0.044 13.2 0.1 0.89 9.0 0.1 2.2 2 0 0 2 2 2 0 PhoH-like protein AAA_6 PF12774.7 EMC81710.1 - 0.044 12.8 0.0 0.14 11.0 0.0 1.8 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region NB-ARC PF00931.22 EMC81710.1 - 0.07 12.3 0.1 2.2 7.4 0.1 2.2 2 0 0 2 2 2 0 NB-ARC domain Bac_DnaA PF00308.18 EMC81710.1 - 0.091 12.6 0.0 0.85 9.4 0.0 2.2 2 0 0 2 2 2 0 Bacterial dnaA protein SKI PF01202.22 EMC81710.1 - 0.1 12.7 0.0 17 5.5 0.0 2.4 2 0 0 2 2 2 0 Shikimate kinase Cytidylate_kin PF02224.18 EMC81710.1 - 0.12 12.1 0.1 3.4 7.4 0.0 2.3 2 0 0 2 2 2 0 Cytidylate kinase AFG1_ATPase PF03969.16 EMC81710.1 - 0.15 11.0 0.0 2.9 6.7 0.0 2.1 2 0 0 2 2 2 0 AFG1-like ATPase ATPase_2 PF01637.18 EMC81710.1 - 0.15 11.9 0.0 8.7 6.2 0.0 2.5 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea Guanylate_kin PF00625.21 EMC81710.1 - 0.24 11.0 0.2 21 4.7 0.0 3.3 2 2 2 4 4 4 0 Guanylate kinase DUF2075 PF09848.9 EMC81710.1 - 0.26 10.5 0.0 0.68 9.1 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Adeno_IVa2 PF02456.15 EMC81710.1 - 0.27 10.0 0.1 13 4.4 0.0 2.6 3 0 0 3 3 3 0 Adenovirus IVa2 protein AAA_lid_3 PF17862.1 EMC81711.1 - 1.9e-14 53.2 0.5 2.7e-14 52.7 0.5 1.1 1 0 0 1 1 1 1 AAA+ lid domain HEPN_SAV_6107 PF18726.1 EMC81711.1 - 0.0043 17.5 0.0 0.005 17.3 0.0 1.1 1 0 0 1 1 1 1 SAV_6107-like HEPN Sprouty PF05210.13 EMC81712.1 - 5.1e-27 94.3 32.5 6.1e-27 94.0 31.6 1.6 1 1 0 1 1 1 1 Sprouty protein (Spry) XPA_C PF05181.12 EMC81713.1 - 9.7e-30 102.3 0.7 1.1e-29 102.2 0.7 1.0 1 0 0 1 1 1 1 XPA protein C-terminus MIF4G_like_2 PF09090.11 EMC81714.1 - 7.9e-86 287.8 3.1 7.9e-86 287.8 3.1 1.5 2 0 0 2 2 2 1 MIF4G like MIF4G_like PF09088.11 EMC81714.1 - 8.1e-37 126.9 0.9 5.4e-36 124.2 0.6 2.3 2 0 0 2 2 2 1 MIF4G like MIF4G PF02854.19 EMC81714.1 - 4.2e-26 91.9 2.2 6.7e-26 91.2 0.1 2.5 3 0 0 3 3 3 1 MIF4G domain DUF4611 PF15387.6 EMC81714.1 - 0.033 14.4 1.0 0.033 14.4 1.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Nuf2 PF03800.14 EMC81714.1 - 0.065 13.4 0.0 3.4 7.8 0.0 2.7 1 1 1 2 2 2 0 Nuf2 family Vfa1 PF08432.10 EMC81714.1 - 0.071 13.4 1.2 0.14 12.5 1.2 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Mis12 PF05859.12 EMC81714.1 - 0.084 12.9 1.9 0.36 10.9 1.4 2.3 2 0 0 2 2 2 0 Mis12 protein ApoA-II PF04711.13 EMC81714.1 - 0.12 12.6 0.6 0.61 10.3 0.0 2.5 3 0 0 3 3 3 0 Apolipoprotein A-II (ApoA-II) DASH_Spc34 PF08657.10 EMC81714.1 - 0.39 10.5 5.7 0.74 9.6 5.7 1.4 1 0 0 1 1 1 0 DASH complex subunit Spc34 PBP1_TM PF14812.6 EMC81714.1 - 0.79 10.1 11.0 0.11 12.9 5.6 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal UPF0176_N PF17773.1 EMC81715.1 - 1.4e-17 63.8 0.0 2.3e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 UPF0176 acylphosphatase like domain Rhodanese_C PF12368.8 EMC81715.1 - 6.8e-16 58.4 11.0 6.8e-16 58.4 11.0 2.1 2 0 0 2 2 2 1 Rhodanase C-terminal Rhodanese PF00581.20 EMC81715.1 - 3.2e-07 30.8 0.1 9.6e-07 29.3 0.0 1.8 2 0 0 2 2 2 1 Rhodanese-like domain NRDD PF13597.6 EMC81715.1 - 0.06 12.1 1.5 0.1 11.3 1.5 1.3 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase Tropomodulin PF03250.14 EMC81716.1 - 4.2e-60 201.9 4.7 4.2e-60 201.9 4.7 1.7 2 0 0 2 2 2 1 Tropomodulin LRR_6 PF13516.6 EMC81716.1 - 0.042 13.9 0.6 0.18 11.9 0.1 2.4 2 0 0 2 2 2 0 Leucine Rich repeat DUF3644 PF12358.8 EMC81716.1 - 0.071 13.6 0.3 0.34 11.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3644) DAGK_acc PF00609.19 EMC81717.1 - 2.4e-50 171.0 0.0 7.7e-50 169.3 0.0 1.9 2 1 0 2 2 2 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 EMC81717.1 - 4.6e-23 81.2 0.0 1.1e-22 79.9 0.0 1.7 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain RA PF00788.23 EMC81717.1 - 6.1e-17 62.0 1.6 2.2e-10 41.0 0.3 3.4 3 0 0 3 3 3 2 Ras association (RalGDS/AF-6) domain C1_1 PF00130.22 EMC81717.1 - 2.4e-16 59.3 39.5 1.4e-11 44.1 6.5 3.7 3 1 0 3 3 3 3 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 EMC81717.1 - 0.011 16.0 4.0 0.011 16.0 4.0 3.9 3 1 1 4 4 4 0 C1 domain Gag_p30 PF02093.16 EMC81718.1 - 4.3e-18 65.6 0.0 4.9e-18 65.4 0.0 1.0 1 0 0 1 1 1 1 Gag P30 core shell protein Aconitase PF00330.20 EMC81719.1 - 2.9e-180 600.2 0.0 3.8e-180 599.8 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EMC81719.1 - 6.8e-46 155.8 0.0 1e-44 152.0 0.0 2.2 2 0 0 2 2 2 1 Aconitase C-terminal domain PNP_UDP_1 PF01048.20 EMC81720.1 - 2.8e-46 157.7 0.0 3.2e-46 157.5 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily NLPC_P60 PF00877.19 EMC81720.1 - 0.033 14.2 0.0 0.069 13.2 0.0 1.6 1 0 0 1 1 1 0 NlpC/P60 family Myb_DNA-bind_7 PF15963.5 EMC81722.1 - 1.4e-28 98.6 4.2 1.4e-28 98.6 4.2 2.6 3 0 0 3 3 3 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EMC81722.1 - 0.00055 20.1 0.0 0.0013 18.9 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain 4F5 PF04419.14 EMC81723.1 - 2.1e-08 34.9 7.0 2.1e-08 34.9 7.0 2.1 2 0 0 2 2 2 1 4F5 protein family BIR PF00653.21 EMC81724.1 - 5.5e-51 171.1 15.2 2.9e-21 75.9 0.8 3.7 3 0 0 3 3 3 3 Inhibitor of Apoptosis domain NLRC4_HD PF17889.1 EMC81724.1 - 3.2e-31 107.8 1.3 1.6e-30 105.6 1.3 2.4 1 0 0 1 1 1 1 NLRC4 helical domain NACHT PF05729.12 EMC81724.1 - 2e-25 89.7 0.0 5.3e-25 88.3 0.0 1.8 1 0 0 1 1 1 1 NACHT domain NOD2_WH PF17779.1 EMC81724.1 - 2.3e-06 27.8 0.1 9.1e-06 25.9 0.1 2.1 1 0 0 1 1 1 1 NOD2 winged helix domain Latarcin PF10279.9 EMC81724.1 - 0.0013 19.0 2.1 5.9 7.4 0.0 4.4 4 1 0 4 4 4 2 Latarcin precursor AAA_22 PF13401.6 EMC81724.1 - 0.02 15.2 0.2 0.58 10.4 0.0 3.2 3 1 1 4 4 4 0 AAA domain AAA_30 PF13604.6 EMC81724.1 - 0.05 13.3 0.0 0.089 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EMC81724.1 - 0.061 12.9 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EMC81724.1 - 0.13 12.7 0.0 0.34 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain LRR_4 PF12799.7 EMC81724.1 - 6.1 7.4 15.7 0.24 11.9 0.4 4.8 4 2 3 7 7 6 0 Leucine Rich repeats (2 copies) Ssl1 PF04056.14 EMC81725.1 - 7.7e-93 309.7 0.1 1e-92 309.2 0.1 1.2 1 0 0 1 1 1 1 Ssl1-like VWA_2 PF13519.6 EMC81725.1 - 3.6e-14 53.3 0.0 9.8e-14 51.9 0.0 1.7 2 0 0 2 2 2 1 von Willebrand factor type A domain C1_4 PF07975.12 EMC81725.1 - 1.4e-10 41.3 25.9 1.1e-09 38.4 19.1 2.9 2 1 0 2 2 2 2 TFIIH C1-like domain VWA PF00092.28 EMC81725.1 - 9.3e-08 32.5 0.0 1.3e-07 32.0 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EMC81725.1 - 0.013 15.5 0.0 0.025 14.5 0.0 1.5 2 0 0 2 2 2 0 von Willebrand factor type A domain IBR PF01485.21 EMC81725.1 - 0.017 15.3 9.6 0.017 15.3 9.6 2.8 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain HscB_4_cys PF18256.1 EMC81725.1 - 0.039 13.8 0.1 0.039 13.8 0.1 2.5 3 0 0 3 3 3 0 Co-chaperone HscB tetracysteine metal binding motif zf-RING_4 PF14570.6 EMC81725.1 - 4.2 7.2 23.7 4.4 7.2 14.9 2.6 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Occludin_ELL PF07303.13 EMC81727.1 - 4e-30 104.5 9.8 4e-30 104.5 9.8 1.9 3 0 0 3 3 3 1 Occludin homology domain MARVEL PF01284.23 EMC81727.1 - 5.4e-17 62.2 8.2 7.1e-17 61.8 8.2 1.2 1 0 0 1 1 1 1 Membrane-associating domain Sec34 PF04136.15 EMC81727.1 - 0.0025 17.7 1.3 0.0038 17.1 0.2 1.8 2 0 0 2 2 2 1 Sec34-like family Tex_N PF09371.10 EMC81727.1 - 0.045 13.4 2.4 0.094 12.4 2.4 1.4 1 0 0 1 1 1 0 Tex-like protein N-terminal domain DUF1241 PF06840.11 EMC81727.1 - 0.075 12.7 0.3 0.15 11.7 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1241) TssO PF17561.2 EMC81727.1 - 0.18 11.9 6.8 0.26 11.4 3.0 2.7 2 1 0 2 2 2 0 Type VI secretion system, TssO DUF202 PF02656.15 EMC81727.1 - 0.68 10.4 5.8 9.2 6.8 1.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF202) Yae1_N PF09811.9 EMC81728.1 - 8e-07 28.7 38.9 56 3.5 29.2 4.6 2 1 0 2 2 2 1 Essential protein Yae1, N terminal Cadherin PF00028.17 EMC81729.1 - 6.1e-33 113.1 1.1 5.9e-13 49.1 0.0 3.3 3 0 0 3 3 3 3 Cadherin domain Cadherin_C PF01049.17 EMC81729.1 - 8.1e-08 32.7 0.1 1.5e-07 31.9 0.1 1.4 1 0 0 1 1 1 1 Cadherin cytoplasmic region PAG PF15347.6 EMC81729.1 - 0.11 11.4 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched Mucin15 PF15672.5 EMC81729.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Cell-membrane associated Mucin15 Orthoreo_P10 PF07204.11 EMC81729.1 - 0.15 12.1 0.5 0.38 10.7 0.5 1.7 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 zf-C2H2 PF00096.26 EMC81730.1 - 3.2e-09 36.7 51.0 0.076 13.5 0.3 8.8 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EMC81730.1 - 9.4e-09 35.3 53.0 0.05 13.9 0.7 8.5 8 0 0 8 8 8 7 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EMC81730.1 - 1.1e-07 32.1 48.9 0.23 12.4 0.1 8.9 8 0 0 8 8 8 5 C2H2-type zinc finger zf-met PF12874.7 EMC81730.1 - 2e-07 31.2 51.5 0.0095 16.3 0.7 8.6 8 0 0 8 8 8 6 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 EMC81730.1 - 0.047 14.0 20.7 0.03 14.6 4.7 5.7 6 0 0 6 6 6 0 C2H2-type zinc ribbon GATA PF00320.27 EMC81730.1 - 0.43 10.2 4.2 14 5.4 0.0 3.6 3 0 0 3 3 3 0 GATA zinc finger zf-C2H2_3 PF13878.6 EMC81730.1 - 2.6 7.9 12.4 13 5.7 0.1 5.9 6 0 0 6 6 6 0 zinc-finger of acetyl-transferase ESCO OrfB_Zn_ribbon PF07282.11 EMC81730.1 - 9 6.3 9.5 0.29 11.1 0.1 3.4 5 0 0 5 5 5 0 Putative transposase DNA-binding domain TLD PF07534.16 EMC81731.1 - 2.8e-39 134.5 0.2 5.6e-39 133.6 0.2 1.5 1 0 0 1 1 1 1 TLD LysM PF01476.20 EMC81731.1 - 1.7e-07 31.2 0.0 3.6e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 LysM domain GRAM PF02893.20 EMC81731.1 - 0.0045 16.9 0.2 0.013 15.4 0.0 1.8 2 0 0 2 2 2 1 GRAM domain DUF3350 PF11830.8 EMC81731.1 - 2.5 8.5 11.6 2.1 8.7 4.8 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3350) Costars PF14705.6 EMC81732.1 - 1.7e-33 114.6 0.1 2.2e-33 114.2 0.1 1.1 1 0 0 1 1 1 1 Costars Slu7 PF11708.8 EMC81733.1 - 0.051 13.3 0.5 41 3.8 0.0 3.7 4 0 0 4 4 4 0 Pre-mRNA splicing Prp18-interacting factor BAF PF02961.14 EMC81734.1 - 2.8e-14 53.3 0.0 2.9e-14 53.3 0.0 1.0 1 0 0 1 1 1 1 Barrier to autointegration factor 7tm_1 PF00001.21 EMC81735.1 - 1.2e-09 37.9 4.5 1.4e-09 37.7 4.5 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ig_3 PF13927.6 EMC81736.1 - 2.5e-30 104.9 11.9 2.8e-07 31.0 0.0 6.6 5 2 1 6 6 6 6 Immunoglobulin domain C2-set_2 PF08205.12 EMC81736.1 - 6.3e-25 87.1 3.1 1.1e-17 63.8 0.0 4.5 4 0 0 4 4 4 3 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 EMC81736.1 - 1.7e-24 85.9 7.5 9e-07 29.2 0.1 5.1 6 0 0 6 6 6 4 Immunoglobulin domain ig PF00047.25 EMC81736.1 - 3.2e-16 59.3 11.9 0.00016 21.8 0.4 7.4 5 3 0 5 5 5 4 Immunoglobulin domain I-set PF07679.16 EMC81736.1 - 5.1e-16 58.5 13.2 0.0014 18.7 0.2 7.7 5 2 0 6 6 6 5 Immunoglobulin I-set domain V-set PF07686.17 EMC81736.1 - 7.5e-10 39.0 10.4 0.0071 16.5 0.0 7.1 5 4 1 7 7 7 2 Immunoglobulin V-set domain C1-set PF07654.15 EMC81736.1 - 1.8e-07 31.4 10.1 0.00015 22.0 0.1 4.5 5 1 1 6 6 4 2 Immunoglobulin C1-set domain Ig_6 PF18452.1 EMC81736.1 - 0.00067 19.2 0.0 0.13 11.8 0.0 3.2 3 0 0 3 3 3 1 Immunoglobulin domain Izumo-Ig PF16706.5 EMC81736.1 - 0.023 14.8 0.3 3.5 7.7 0.0 3.5 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Podoplanin PF05808.11 EMC81736.1 - 0.037 14.1 0.7 0.08 13.1 0.7 1.6 1 0 0 1 1 1 0 Podoplanin DUF5450 PF17529.2 EMC81736.1 - 0.074 13.2 0.0 0.2 11.8 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5450) PepSY_TM PF03929.16 EMC81736.1 - 0.14 11.8 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 PepSY-associated TM region PAP_PilO PF06864.12 EMC81736.1 - 0.18 10.6 0.0 0.27 10.0 0.0 1.2 1 0 0 1 1 1 0 Pilin accessory protein (PilO) DUF1661 PF07877.11 EMC81737.1 - 0.013 15.2 0.1 0.013 15.2 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1661) DUF2028 PF09667.10 EMC81738.1 - 2.1e-33 116.0 22.7 7.9e-31 107.6 17.7 3.8 2 1 1 3 3 3 2 Domain of unknown function (DUF2028) HMG_box PF00505.19 EMC81738.1 - 3.3e-17 62.6 0.8 9.8e-17 61.1 0.8 1.9 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC81738.1 - 3.8e-11 43.4 1.0 1.8e-10 41.3 1.0 2.3 1 0 0 1 1 1 1 HMG-box domain Caldesmon PF02029.15 EMC81739.1 - 3e-150 501.2 201.3 5.6e-120 401.4 28.9 3.2 1 1 2 3 3 3 2 Caldesmon Ras PF00071.22 EMC81740.1 - 1.3e-30 106.1 0.0 1.8e-30 105.7 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC81740.1 - 0.00016 21.9 0.0 0.00033 20.9 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC81740.1 - 0.00037 20.0 0.0 0.00049 19.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Y_phosphatase PF00102.27 EMC81741.1 - 1.5e-83 279.9 2.6 1.5e-83 279.9 2.6 1.9 2 0 0 2 2 2 1 Protein-tyrosine phosphatase fn3 PF00041.21 EMC81741.1 - 7.9e-28 96.6 19.3 1.7e-08 34.6 0.6 6.3 6 0 0 6 6 6 5 Fibronectin type III domain DSPc PF00782.20 EMC81741.1 - 5.6e-05 23.0 0.0 0.00021 21.1 0.0 1.9 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC81741.1 - 6.1e-05 23.1 0.0 0.00011 22.3 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EMC81741.1 - 0.00063 19.9 0.0 0.0017 18.5 0.0 1.8 1 0 0 1 1 1 1 Inositol hexakisphosphate Pur_ac_phosph_N PF16656.5 EMC81741.1 - 0.011 16.2 15.7 0.41 11.2 0.9 4.3 4 1 0 4 4 4 0 Purple acid Phosphatase, N-terminal domain PTB PF08416.13 EMC81742.1 - 2.6e-52 176.4 1.4 5.1e-52 175.5 1.4 1.5 1 0 0 1 1 1 1 Phosphotyrosine-binding domain SAM_3 PF18016.1 EMC81742.1 - 2.3e-23 81.8 0.0 5.5e-23 80.5 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_1 PF00018.28 EMC81742.1 - 1.3e-10 40.8 0.0 2.6e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC81742.1 - 1.3e-05 25.0 0.0 2.7e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PID PF00640.23 EMC81742.1 - 1.6e-05 24.9 1.7 2.3e-05 24.5 0.2 2.0 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) SH3_2 PF07653.17 EMC81742.1 - 6e-05 22.6 0.0 0.00012 21.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 EMC81742.1 - 0.002 18.4 0.1 0.0052 17.0 0.1 1.7 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_10 PF17902.1 EMC81742.1 - 0.016 15.2 0.2 0.071 13.2 0.0 2.1 2 0 0 2 2 2 0 SH3 domain SAM_PNT PF02198.16 EMC81742.1 - 0.092 12.7 0.0 0.27 11.2 0.0 1.8 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain GreA_GreB_N PF03449.15 EMC81742.1 - 8.3 6.6 6.9 0.57 10.4 0.1 2.7 3 0 0 3 3 3 0 Transcription elongation factor, N-terminal PSP1 PF04468.12 EMC81743.1 - 0.029 14.6 0.9 0.052 13.8 0.1 1.8 2 0 0 2 2 2 0 PSP1 C-terminal conserved region WD40 PF00400.32 EMC81744.1 - 4.8e-33 112.7 2.8 6.4e-10 39.5 0.0 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC81744.1 - 1.6e-08 34.7 0.0 0.17 12.2 0.0 4.6 2 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMC81744.1 - 0.0086 15.1 0.0 0.22 10.5 0.0 2.4 2 0 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EMC81744.1 - 0.033 13.5 0.0 0.24 10.7 0.0 2.2 1 1 0 2 2 2 0 WD40-like domain Cytochrom_D1 PF02239.16 EMC81744.1 - 0.038 12.5 0.1 0.89 8.0 0.0 2.0 1 1 1 2 2 2 0 Cytochrome D1 heme domain Me-amine-dh_H PF06433.11 EMC81744.1 - 0.067 12.1 0.2 1.9 7.2 0.1 2.7 2 2 1 3 3 3 0 Methylamine dehydrogenase heavy chain (MADH) Frtz PF11768.8 EMC81744.1 - 0.082 11.2 0.0 5.1 5.3 0.0 2.4 3 0 0 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz DeoC PF01791.9 EMC81745.1 - 3.4e-25 89.1 0.0 4.3e-25 88.7 0.0 1.1 1 0 0 1 1 1 1 DeoC/LacD family aldolase PTR2 PF00854.21 EMC81746.1 - 4.9e-43 147.5 11.1 6.8e-43 147.0 11.1 1.1 1 0 0 1 1 1 1 POT family TPR_1 PF00515.28 EMC81746.1 - 0.054 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat MAPEG PF01124.18 EMC81747.1 - 8.9e-23 80.6 0.1 1e-22 80.4 0.1 1.0 1 0 0 1 1 1 1 MAPEG family LIM PF00412.22 EMC81748.1 - 1.4e-30 105.3 22.1 3.7e-15 55.9 8.1 2.0 2 0 0 2 2 2 2 LIM domain PrmA PF06325.13 EMC81749.1 - 8e-10 38.6 0.0 4.1e-09 36.3 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) TPR_2 PF07719.17 EMC81749.1 - 7e-07 28.9 3.6 0.0026 17.8 0.0 3.8 4 0 0 4 4 3 2 Tetratricopeptide repeat Methyltransf_18 PF12847.7 EMC81749.1 - 1.1e-05 25.4 0.0 2.6e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC81749.1 - 1.2e-05 26.0 0.0 4e-05 24.3 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain TPR_1 PF00515.28 EMC81749.1 - 5.1e-05 22.9 0.9 0.26 11.2 0.0 2.9 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMC81749.1 - 8.6e-05 23.0 0.4 0.089 13.7 0.0 3.5 2 1 1 3 3 3 1 Tetratricopeptide repeat Methyltransf_16 PF10294.9 EMC81749.1 - 0.00036 20.3 0.0 0.00085 19.1 0.0 1.6 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 EMC81749.1 - 0.00076 19.1 0.0 0.0017 17.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain TPR_11 PF13414.6 EMC81749.1 - 0.0092 15.7 0.0 2.6 7.8 0.0 2.7 2 0 0 2 2 2 1 TPR repeat CMAS PF02353.20 EMC81749.1 - 0.011 15.0 0.0 0.033 13.5 0.0 1.7 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 EMC81749.1 - 0.013 16.1 0.0 0.044 14.4 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EMC81749.1 - 0.026 14.4 0.0 0.051 13.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 EMC81749.1 - 0.077 12.1 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase DREV PF05219.12 EMC81749.1 - 0.13 11.4 0.0 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_12 PF08242.12 EMC81749.1 - 0.15 12.8 0.0 0.46 11.3 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain TPR_16 PF13432.6 EMC81749.1 - 0.17 12.5 0.1 0.52 11.0 0.1 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Solute_trans_a PF03619.16 EMC81750.1 - 2.1e-101 338.9 19.6 2.5e-101 338.6 19.6 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha 7tm_1 PF00001.21 EMC81751.1 - 3.1e-35 121.8 9.3 3.1e-35 121.8 9.3 1.9 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC81751.1 - 0.0048 16.3 15.8 0.074 12.4 13.2 3.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC81751.1 - 0.007 16.1 2.7 0.01 15.6 2.7 1.5 1 1 0 1 1 1 1 Olfactory receptor TPR_12 PF13424.6 EMC81752.1 - 8.1e-11 42.1 14.5 0.0017 18.6 0.1 4.6 2 1 2 6 6 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 EMC81752.1 - 8.5e-08 31.7 10.1 0.0053 16.5 0.4 5.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EMC81752.1 - 1.2e-07 31.3 12.8 0.02 15.0 0.1 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EMC81752.1 - 3.6e-07 29.9 4.5 6.1e-07 29.1 0.9 2.3 1 1 1 2 2 2 1 MalT-like TPR region TPR_2 PF07719.17 EMC81752.1 - 2.3e-06 27.3 16.6 0.57 10.4 0.4 5.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 EMC81752.1 - 7.4e-06 26.4 3.9 2.4 9.2 0.0 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMC81752.1 - 3.1e-05 24.4 4.3 0.65 10.6 0.2 3.7 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 EMC81752.1 - 4.7e-05 23.1 2.5 18 5.7 0.0 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 EMC81752.1 - 0.00037 20.3 6.1 0.16 11.9 0.3 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 EMC81752.1 - 0.0022 18.2 4.1 2.8 8.5 0.1 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC81752.1 - 0.0022 18.2 9.4 0.56 10.5 0.4 4.1 2 1 2 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 SHNi-TPR PF10516.9 EMC81752.1 - 0.0057 16.1 0.0 2.5 7.6 0.0 2.7 2 0 0 2 2 2 1 SHNi-TPR TPR_11 PF13414.6 EMC81752.1 - 0.0061 16.2 3.1 1.8 8.3 0.7 4.3 4 0 0 4 4 4 1 TPR repeat RPN7 PF10602.9 EMC81752.1 - 0.0074 16.0 5.4 1.5 8.5 0.9 2.9 1 1 2 3 3 3 2 26S proteasome subunit RPN7 TPR_20 PF14561.6 EMC81752.1 - 0.066 13.5 6.4 16 6.0 0.4 4.5 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 EMC81752.1 - 0.11 13.1 3.5 29 5.7 0.1 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMC81752.1 - 0.99 10.2 9.8 1.2e+02 3.7 0.1 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat SBF_like PF13593.6 EMC81753.1 - 9.7e-74 248.5 21.3 1.1e-73 248.3 21.3 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) SBF PF01758.16 EMC81753.1 - 2.4e-16 60.0 12.5 2.4e-16 60.0 12.5 2.3 2 1 0 2 2 2 1 Sodium Bile acid symporter family Oxidored_q4 PF00507.19 EMC81753.1 - 2 8.7 8.3 0.16 12.2 2.0 2.4 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 Phtf-FEM1B_bdg PF12129.8 EMC81753.1 - 4.1 7.2 8.6 0.96 9.3 1.0 2.7 2 2 0 2 2 2 0 Male germ-cell putative homeodomain transcription factor DUF373 PF04123.13 EMC81753.1 - 7.2 6.0 8.3 1e+02 2.2 8.6 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF373) Reeler PF02014.16 EMC81754.1 - 3.1e-30 105.6 0.0 3.7e-30 105.3 0.0 1.1 1 0 0 1 1 1 1 Reeler domain LSM PF01423.22 EMC81755.1 - 8.3e-20 70.3 0.1 9.4e-20 70.1 0.1 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EMC81755.1 - 4.1e-05 23.6 0.0 4.8e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 EMC81755.1 - 0.027 14.6 0.1 0.029 14.4 0.1 1.2 1 0 0 1 1 1 0 Scd6-like Sm domain MeaB PF03308.16 EMC81756.1 - 9.3e-95 316.6 0.3 1.3e-94 316.2 0.3 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 EMC81756.1 - 5.7e-06 26.7 2.0 0.0003 21.1 0.1 2.8 3 0 0 3 3 3 1 AAA domain cobW PF02492.19 EMC81756.1 - 4e-05 23.3 0.1 0.00021 20.9 0.1 2.1 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.17 EMC81756.1 - 0.00018 21.4 0.0 0.00044 20.1 0.0 1.6 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_33 PF13671.6 EMC81756.1 - 0.001 19.2 1.1 0.11 12.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EMC81756.1 - 0.0025 18.4 0.2 0.0082 16.7 0.0 1.9 2 1 0 2 2 1 1 ABC transporter AAA_30 PF13604.6 EMC81756.1 - 0.0037 17.0 0.0 0.0064 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EMC81756.1 - 0.0061 16.6 0.0 0.43 10.7 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EMC81756.1 - 0.0062 16.9 1.8 0.19 12.1 0.1 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 EMC81756.1 - 0.0068 16.9 0.8 0.014 16.0 0.1 1.8 1 1 1 2 2 2 1 AAA domain Thymidylate_kin PF02223.17 EMC81756.1 - 0.011 15.5 0.0 0.024 14.3 0.0 1.6 1 0 0 1 1 1 0 Thymidylate kinase AAA_18 PF13238.6 EMC81756.1 - 0.02 15.4 1.4 0.039 14.5 0.1 2.2 2 0 0 2 2 1 0 AAA domain HD_assoc PF13286.6 EMC81756.1 - 0.023 15.3 0.4 0.25 11.9 0.1 2.5 2 1 0 2 2 2 0 Phosphohydrolase-associated domain SRP54 PF00448.22 EMC81756.1 - 0.03 14.0 0.0 0.16 11.6 0.0 2.0 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain Mg_chelatase PF01078.21 EMC81756.1 - 0.031 13.7 0.1 0.2 11.0 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 EMC81756.1 - 0.034 14.0 0.0 0.068 13.1 0.0 1.5 1 0 0 1 1 1 0 NTPase KAP_NTPase PF07693.14 EMC81756.1 - 0.046 13.0 0.0 0.076 12.2 0.0 1.4 1 0 0 1 1 1 0 KAP family P-loop domain CbiA PF01656.23 EMC81756.1 - 0.054 13.5 0.0 0.17 11.9 0.0 1.7 2 1 0 2 2 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_29 PF13555.6 EMC81756.1 - 0.062 13.1 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 EMC81756.1 - 0.062 13.2 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain RNA_helicase PF00910.22 EMC81756.1 - 0.07 13.5 0.1 0.28 11.6 0.0 2.1 2 0 0 2 2 2 0 RNA helicase MnmE_helical PF12631.7 EMC81756.1 - 0.074 13.2 0.0 0.12 12.5 0.0 1.4 1 1 0 1 1 1 0 MnmE helical domain AAA PF00004.29 EMC81756.1 - 0.11 13.0 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) KTI12 PF08433.10 EMC81756.1 - 0.11 11.9 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 RsgA_GTPase PF03193.16 EMC81756.1 - 0.12 12.2 0.1 1.1 9.2 0.1 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_24 PF13479.6 EMC81756.1 - 0.13 12.0 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain CLP1_P PF16575.5 EMC81756.1 - 0.17 11.7 0.0 0.42 10.4 0.0 1.6 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop OTU PF02338.19 EMC81757.1 - 7.9e-07 29.6 0.0 1.9e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 OTU-like cysteine protease SMN PF06003.12 EMC81757.1 - 0.0026 17.1 0.0 0.0026 17.1 0.0 3.7 3 0 0 3 3 3 1 Survival motor neuron protein (SMN) DUF3568 PF12092.8 EMC81757.1 - 0.28 11.2 1.7 0.69 10.0 1.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3568) ABC_tran PF00005.27 EMC81758.1 - 7.4e-38 130.2 0.0 1.5e-18 67.6 0.0 2.3 2 0 0 2 2 2 2 ABC transporter RLI PF04068.15 EMC81758.1 - 1.4e-14 53.6 7.2 4.2e-14 52.1 7.2 1.9 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N PF02463.19 EMC81758.1 - 4.3e-11 42.7 1.6 0.0021 17.5 0.0 4.0 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EMC81758.1 - 9.5e-11 42.0 2.9 0.17 11.7 0.7 4.4 3 2 0 5 5 4 3 AAA domain, putative AbiEii toxin, Type IV TA system Fer4 PF00037.27 EMC81758.1 - 1.1e-07 31.3 1.6 1.1e-07 31.3 1.6 3.7 5 0 0 5 5 4 1 4Fe-4S binding domain AAA_16 PF13191.6 EMC81758.1 - 1.1e-05 25.8 0.0 0.027 14.8 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_15 PF13175.6 EMC81758.1 - 1.5e-05 24.9 0.0 0.22 11.2 0.0 3.1 3 0 0 3 3 3 2 AAA ATPase domain AAA PF00004.29 EMC81758.1 - 3.1e-05 24.4 0.0 0.05 14.0 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EMC81758.1 - 4e-05 23.6 0.0 0.14 12.0 0.0 2.8 2 0 0 2 2 2 2 RsgA GTPase Fer4_6 PF12837.7 EMC81758.1 - 4.3e-05 23.4 0.9 4.3e-05 23.4 0.9 3.3 4 0 0 4 4 2 1 4Fe-4S binding domain AAA_22 PF13401.6 EMC81758.1 - 4.9e-05 23.6 0.0 0.011 16.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EMC81758.1 - 9.3e-05 22.1 0.4 0.54 10.0 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain NACHT PF05729.12 EMC81758.1 - 0.00054 19.9 0.4 0.091 12.7 0.0 2.5 2 0 0 2 2 2 1 NACHT domain Rad17 PF03215.15 EMC81758.1 - 0.0013 18.7 0.0 0.67 9.8 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_30 PF13604.6 EMC81758.1 - 0.0016 18.2 0.2 0.079 12.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EMC81758.1 - 0.0019 18.7 2.7 0.061 13.8 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EMC81758.1 - 0.0022 18.2 0.0 0.49 10.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EMC81758.1 - 0.0022 17.8 0.2 0.57 9.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain Fer4_7 PF12838.7 EMC81758.1 - 0.0023 18.5 9.7 0.0067 17.0 1.2 3.2 2 2 2 4 4 4 2 4Fe-4S dicluster domain RNA_helicase PF00910.22 EMC81758.1 - 0.0024 18.2 0.0 2.1 8.8 0.0 3.4 3 0 0 3 3 3 1 RNA helicase SRP54 PF00448.22 EMC81758.1 - 0.003 17.2 1.9 0.31 10.6 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Fer4_2 PF12797.7 EMC81758.1 - 0.0031 17.5 0.7 0.0031 17.5 0.7 3.1 3 0 0 3 3 2 1 4Fe-4S binding domain Fer4_9 PF13187.6 EMC81758.1 - 0.0063 16.7 10.0 0.0063 16.7 10.0 2.0 2 0 0 2 2 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 EMC81758.1 - 0.0085 16.2 15.5 0.0085 16.2 1.7 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain AAA_28 PF13521.6 EMC81758.1 - 0.011 16.0 0.2 4.4 7.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain Fer4_21 PF14697.6 EMC81758.1 - 0.011 15.8 13.3 0.031 14.4 12.9 2.0 1 1 1 2 2 2 0 4Fe-4S dicluster domain TsaE PF02367.17 EMC81758.1 - 0.014 15.4 0.2 0.23 11.5 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Fer4_16 PF13484.6 EMC81758.1 - 0.028 15.4 0.9 0.028 15.4 0.9 2.9 3 0 0 3 3 2 0 4Fe-4S double cluster binding domain AAA_18 PF13238.6 EMC81758.1 - 0.041 14.4 0.0 9.1 6.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain Septin PF00735.18 EMC81758.1 - 0.079 12.2 0.1 4 6.6 0.0 2.6 3 0 0 3 3 3 0 Septin AAA_5 PF07728.14 EMC81758.1 - 0.083 12.9 1.1 1.2 9.2 0.0 2.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) MMR_HSR1 PF01926.23 EMC81758.1 - 0.085 12.9 0.7 19 5.4 0.0 2.8 2 1 0 2 2 2 0 50S ribosome-binding GTPase NB-ARC PF00931.22 EMC81758.1 - 0.089 12.0 0.0 6.9 5.8 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain VirE PF05272.11 EMC81758.1 - 0.1 12.3 0.0 5.4 6.7 0.0 2.3 2 0 0 2 2 2 0 Virulence-associated protein E AAA_7 PF12775.7 EMC81758.1 - 0.12 11.9 0.2 1.3 8.6 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region MeaB PF03308.16 EMC81758.1 - 0.13 11.2 0.1 8 5.4 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CLP1_P PF16575.5 EMC81758.1 - 0.16 11.8 0.1 1.2 8.9 0.0 2.2 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop SbcCD_C PF13558.6 EMC81758.1 - 0.21 11.9 0.1 14 6.0 0.0 2.9 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_14 PF13173.6 EMC81758.1 - 0.39 10.8 3.1 29 4.7 0.0 3.6 3 1 1 4 4 3 0 AAA domain Fer4_17 PF13534.6 EMC81758.1 - 0.92 10.1 9.1 0.09 13.3 0.7 2.7 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_4 PF12800.7 EMC81758.1 - 5.9 7.7 15.1 0.45 11.1 2.2 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain ANAPC10 PF03256.16 EMC81759.1 - 4.2e-83 277.5 0.0 5e-83 277.3 0.0 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 EMC81759.1 - 4.5e-05 23.6 0.0 5.9e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 F5/8 type C domain PITH PF06201.13 EMC81759.1 - 0.0018 18.5 0.1 0.011 15.9 0.1 1.9 1 1 1 2 2 2 1 PITH domain PH PF00169.29 EMC81760.1 - 2.8e-19 69.5 2.8 1.3e-18 67.4 0.1 3.0 3 0 0 3 3 3 1 PH domain PH_11 PF15413.6 EMC81760.1 - 2e-05 24.9 0.3 0.00011 22.5 0.3 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH_13 PF16652.5 EMC81760.1 - 0.045 13.6 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain PH_3 PF14593.6 EMC81760.1 - 0.11 12.6 0.3 0.3 11.2 0.3 1.7 1 1 0 1 1 1 0 PH domain Phage_TAC_5 PF08890.11 EMC81760.1 - 0.22 11.5 0.1 0.64 10.0 0.0 1.7 2 0 0 2 2 2 0 Phage XkdN-like tail assembly chaperone protein, TAC PH_2 PF08458.10 EMC81760.1 - 0.23 11.8 0.0 0.43 11.0 0.0 1.4 1 0 0 1 1 1 0 Plant pleckstrin homology-like region IL15 PF02372.15 EMC81763.1 - 2.4e-44 150.6 10.7 3.2e-44 150.2 10.7 1.2 1 0 0 1 1 1 1 Interleukin 15 RhoGEF PF00621.20 EMC81763.1 - 0.012 15.9 3.3 0.013 15.8 3.3 1.1 1 0 0 1 1 1 0 RhoGEF domain CTD_bind PF04818.13 EMC81763.1 - 0.032 15.1 1.1 0.45 11.4 0.3 2.6 2 1 0 2 2 2 0 RNA polymerase II-binding domain. NOA36 PF06524.12 EMC81764.1 - 7.3e-156 518.2 40.3 8.9e-156 517.9 40.3 1.0 1 0 0 1 1 1 1 NOA36 protein zf-RING_2 PF13639.6 EMC81765.1 - 2.6e-12 46.9 6.6 5.5e-12 45.8 6.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EMC81765.1 - 4.4e-10 39.1 1.5 1e-09 37.9 1.5 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EMC81765.1 - 4.1e-08 32.9 6.4 8.2e-08 32.0 6.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC81765.1 - 1.9e-07 30.8 4.7 4e-07 29.8 4.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC81765.1 - 4.4e-07 29.8 3.5 8.7e-07 28.8 3.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EMC81765.1 - 2.8e-06 27.5 7.9 8.1e-06 26.0 7.9 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EMC81765.1 - 4e-06 26.6 4.4 4e-06 26.6 4.4 1.8 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 PA PF02225.22 EMC81765.1 - 4.4e-06 26.6 0.0 9.1e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 PA domain zf-C3HC4_3 PF13920.6 EMC81765.1 - 1.4e-05 24.8 3.6 2.8e-05 23.9 3.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC81765.1 - 1.9e-05 24.5 4.7 4e-05 23.5 4.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger PspB PF06667.12 EMC81765.1 - 0.0029 17.6 0.2 0.0051 16.8 0.2 1.3 1 0 0 1 1 1 1 Phage shock protein B CrgA PF06781.12 EMC81765.1 - 0.0034 17.4 0.2 0.0076 16.3 0.2 1.6 1 0 0 1 1 1 1 Cell division protein CrgA Ninjurin PF04923.12 EMC81765.1 - 0.0039 17.1 0.5 0.0088 16.0 0.5 1.5 1 0 0 1 1 1 1 Ninjurin zf-ANAPC11 PF12861.7 EMC81765.1 - 0.011 15.7 2.3 0.022 14.8 2.3 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger BatD PF13584.6 EMC81765.1 - 0.042 12.7 0.0 0.062 12.1 0.0 1.1 1 0 0 1 1 1 0 Oxygen tolerance Zn_ribbon_17 PF17120.5 EMC81765.1 - 0.1 12.3 5.2 0.64 9.7 5.8 1.9 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type PHD PF00628.29 EMC81765.1 - 0.33 10.9 7.7 0.5 10.3 4.3 2.4 2 0 0 2 2 2 0 PHD-finger zf-C3H2C3 PF17122.5 EMC81765.1 - 2.8 8.1 8.8 0.14 12.2 2.7 2.1 2 0 0 2 2 2 0 Zinc-finger RINGv PF12906.7 EMC81765.1 - 5.5 7.2 8.1 1.4 9.1 4.4 1.9 2 0 0 2 2 2 0 RING-variant domain RabGAP-TBC PF00566.18 EMC81766.1 - 2.1e-46 158.3 0.1 1e-45 156.1 0.0 2.2 2 0 0 2 2 2 1 Rab-GTPase-TBC domain GRAM PF02893.20 EMC81766.1 - 2.7e-41 140.0 1.6 3.1e-22 78.6 0.1 2.5 2 0 0 2 2 2 2 GRAM domain EF-hand_1 PF00036.32 EMC81766.1 - 0.019 14.5 0.1 0.4 10.3 0.0 2.8 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.6 EMC81766.1 - 0.14 12.2 0.1 0.93 9.6 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain ELMO_CED12 PF04727.13 EMC81767.1 - 3.9e-48 163.9 0.2 6e-48 163.3 0.2 1.2 1 0 0 1 1 1 1 ELMO/CED-12 family Glyco_transf_54 PF04666.13 EMC81768.1 - 7.5e-122 405.7 0.8 9e-122 405.5 0.8 1.1 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Calreticulin PF00262.18 EMC81769.1 - 5.3e-164 545.4 14.4 6.5e-164 545.1 14.4 1.0 1 0 0 1 1 1 1 Calreticulin family DUF2205 PF10224.9 EMC81770.1 - 5.9e-28 96.7 4.0 7.9e-28 96.3 4.0 1.2 1 0 0 1 1 1 1 Short coiled-coil protein HALZ PF02183.18 EMC81770.1 - 0.00061 20.0 8.1 0.049 13.9 2.5 3.0 1 1 1 2 2 2 2 Homeobox associated leucine zipper bZIP_1 PF00170.21 EMC81770.1 - 0.006 16.7 1.0 0.006 16.7 1.0 2.0 1 1 1 2 2 2 1 bZIP transcription factor YabA PF06156.13 EMC81770.1 - 0.0061 17.2 4.1 0.0082 16.8 3.8 1.5 1 1 0 1 1 1 1 Initiation control protein YabA Nse5 PF08691.10 EMC81770.1 - 0.0086 14.8 0.1 0.0086 14.8 0.1 1.1 1 0 0 1 1 1 1 DNA repair proteins Nse5 and Nse6 CENP-H PF05837.12 EMC81770.1 - 0.011 16.1 3.0 0.011 16.1 3.0 1.6 1 1 0 1 1 1 0 Centromere protein H (CENP-H) FlaC_arch PF05377.11 EMC81770.1 - 0.017 15.5 1.1 0.017 15.5 1.1 1.9 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DASH_Dad4 PF08650.10 EMC81770.1 - 0.042 13.8 2.3 0.047 13.7 1.7 1.5 1 1 1 2 2 2 0 DASH complex subunit Dad4 DUF2683 PF10884.8 EMC81770.1 - 0.046 14.0 0.3 0.059 13.6 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2683) ZapB PF06005.12 EMC81770.1 - 0.076 13.5 8.2 0.11 12.9 7.6 1.6 1 1 1 2 2 2 0 Cell division protein ZapB DivIC PF04977.15 EMC81770.1 - 0.18 11.6 5.8 0.091 12.5 1.1 2.1 1 1 1 2 2 2 0 Septum formation initiator DUF349 PF03993.12 EMC81770.1 - 0.22 11.8 3.1 0.38 11.1 2.6 1.7 1 1 1 2 2 2 0 Domain of Unknown Function (DUF349) DUF4407 PF14362.6 EMC81771.1 - 0.73 9.1 6.0 0.96 8.7 0.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) MAPEG PF01124.18 EMC81772.1 - 2.7e-05 24.1 2.3 3.1e-05 23.9 2.3 1.1 1 0 0 1 1 1 1 MAPEG family MORN PF02493.20 EMC81773.1 - 2.8e-14 52.0 21.8 0.00097 18.9 0.9 6.9 7 0 0 7 7 7 4 MORN repeat MORN_2 PF07661.13 EMC81773.1 - 0.049 13.9 8.5 0.25 11.7 0.0 5.3 6 0 0 6 6 6 0 MORN repeat variant CD20 PF04103.15 EMC81774.1 - 4.5e-18 65.8 11.8 1.3e-17 64.3 11.8 1.6 1 1 0 1 1 1 1 CD20-like family PMP22_Claudin PF00822.20 EMC81774.1 - 0.19 11.6 6.9 0.093 12.6 4.1 1.8 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family Caps_synth_CapC PF14102.6 EMC81774.1 - 0.31 11.5 6.2 0.15 12.5 3.2 2.1 1 1 0 1 1 1 0 Capsule biosynthesis CapC DUF5518 PF17647.1 EMC81774.1 - 0.38 10.9 9.9 0.056 13.6 5.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5518) SUR7 PF06687.12 EMC81774.1 - 1.9 8.1 10.2 11 5.5 6.0 2.4 1 1 1 2 2 2 0 SUR7/PalI family Tetraspanin PF00335.20 EMC81774.1 - 2.3 7.9 8.7 0.38 10.4 4.9 1.5 1 1 1 2 2 2 0 Tetraspanin family Ras PF00071.22 EMC81775.1 - 2.5e-30 105.2 0.0 2.8e-30 105.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC81775.1 - 1e-16 61.2 0.1 1.6e-16 60.6 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC81775.1 - 7.4e-09 35.3 0.0 8e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EMC81775.1 - 0.00017 20.9 0.1 0.0005 19.3 0.1 1.7 1 1 0 1 1 1 1 G-protein alpha subunit GTP_EFTU PF00009.27 EMC81775.1 - 0.00052 19.6 0.0 0.00059 19.4 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EMC81775.1 - 0.0007 19.0 0.0 0.00074 18.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMC81775.1 - 0.087 12.9 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase SRPRB PF09439.10 EMC81775.1 - 0.092 12.2 0.0 0.1 12.0 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit NARP1 PF12569.8 EMC81776.1 - 6.6e-224 744.6 23.8 6.6e-224 744.6 23.8 1.7 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 EMC81776.1 - 1.3e-15 56.1 23.1 0.00034 20.5 0.1 9.0 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_14 PF13428.6 EMC81776.1 - 1.4e-12 47.3 7.4 0.067 14.0 0.0 9.0 7 2 2 9 9 8 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMC81776.1 - 5.7e-12 44.9 25.5 0.00026 21.0 0.1 9.0 9 0 0 9 9 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMC81776.1 - 1.6e-11 44.5 19.4 0.0038 17.7 0.3 7.2 4 2 4 8 8 7 4 Tetratricopeptide repeat TPR_16 PF13432.6 EMC81776.1 - 8.4e-11 42.3 7.1 0.042 14.5 0.0 5.3 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 EMC81776.1 - 2.5e-09 36.6 23.7 0.0025 17.5 0.2 8.9 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 EMC81776.1 - 2.6e-09 36.6 5.0 0.00026 20.6 0.1 5.0 6 0 0 6 6 6 2 TPR repeat TPR_9 PF13371.6 EMC81776.1 - 3.3e-06 27.1 5.1 0.32 11.2 0.2 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMC81776.1 - 9.9e-06 25.8 20.2 0.92 9.8 2.5 7.5 7 2 0 7 7 7 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC81776.1 - 7.7e-05 22.8 26.6 0.017 15.4 2.7 7.1 4 2 4 8 8 8 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.14 EMC81776.1 - 0.00036 20.9 0.1 13 6.8 0.0 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 EMC81776.1 - 0.00084 19.2 14.2 1.3 9.2 0.1 7.2 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 EMC81776.1 - 0.0025 18.4 10.1 23 5.9 0.0 7.5 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_15 PF13429.6 EMC81776.1 - 0.01 15.0 12.4 0.011 15.0 3.1 4.2 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_21 PF09976.9 EMC81776.1 - 0.027 14.2 0.3 0.027 14.2 0.3 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat-like domain TPR_3 PF07720.12 EMC81776.1 - 0.077 13.0 2.2 15 5.7 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMC81776.1 - 0.12 12.4 7.8 24 5.1 0.1 5.1 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat Vfa1 PF08432.10 EMC81776.1 - 0.36 11.1 14.2 1.1 9.5 14.2 1.8 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Peptidase_S30 PF01577.16 EMC81776.1 - 1.1 8.8 8.8 2 8.0 8.8 1.3 1 0 0 1 1 1 0 Potyvirus P1 protease Coilin_N PF15862.5 EMC81776.1 - 1.5 8.6 12.6 1.7 8.5 11.2 1.8 2 0 0 2 2 1 0 Coilin N-terminus F-protein PF00469.20 EMC81776.1 - 1.6 8.3 7.2 1.2 8.7 5.4 1.7 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef PPR PF01535.20 EMC81776.1 - 4.2 7.8 9.7 4.7 7.7 0.0 5.8 7 0 0 7 7 6 0 PPR repeat DDRGK PF09756.9 EMC81776.1 - 7.5 6.1 21.2 13 5.3 18.3 2.2 2 0 0 2 2 2 0 DDRGK domain TPR_10 PF13374.6 EMC81776.1 - 8 6.5 14.4 1.5e+02 2.4 0.1 6.9 8 0 0 8 8 7 0 Tetratricopeptide repeat Elf-1_N PF12310.8 EMC81778.1 - 1.7e-41 141.2 3.3 1.7e-41 141.2 3.3 2.6 4 0 0 4 4 4 1 Transcription factor protein N terminal Ets PF00178.22 EMC81778.1 - 1.9e-34 118.0 1.2 3.1e-34 117.3 1.2 1.4 1 0 0 1 1 1 1 Ets-domain Exo_endo_phos PF03372.23 EMC81779.1 - 1.1e-23 84.0 0.0 1.3e-23 83.7 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family E3_UbLigase_EDD PF11547.8 EMC81779.1 - 0.003 17.2 0.8 2.1 8.1 0.1 2.8 3 0 0 3 3 3 2 E3 ubiquitin ligase EDD Exo_endo_phos_2 PF14529.6 EMC81779.1 - 0.004 17.0 0.0 0.025 14.4 0.0 2.4 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase AA_permease_2 PF13520.6 EMC81780.1 - 4.4e-60 203.7 39.4 5.3e-60 203.4 39.4 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMC81780.1 - 8.1e-31 107.1 36.9 1.3e-30 106.4 36.9 1.3 1 1 0 1 1 1 1 Amino acid permease Cadherin PF00028.17 EMC81781.1 - 4.3e-83 273.9 2.8 2e-16 60.2 0.0 6.5 5 1 1 6 6 6 6 Cadherin domain Cadherin_2 PF08266.12 EMC81781.1 - 1.2e-14 53.9 1.0 3.8e-13 49.1 0.1 3.5 5 0 0 5 5 5 1 Cadherin-like Cadherin_3 PF16184.5 EMC81781.1 - 7.9e-06 25.8 7.5 0.31 11.1 0.2 5.1 4 1 1 5 5 5 3 Cadherin-like Cadherin_C_2 PF16492.5 EMC81781.1 - 0.00025 21.7 0.6 0.0016 19.1 0.6 2.6 1 1 0 1 1 1 1 Cadherin cytoplasmic C-terminal Syndecan PF01034.20 EMC81781.1 - 0.039 13.9 0.0 0.09 12.7 0.0 1.6 1 0 0 1 1 1 0 Syndecan domain Filamin PF00630.19 EMC81781.1 - 0.34 11.8 3.6 43 5.0 2.3 3.9 2 2 0 2 2 2 0 Filamin/ABP280 repeat FAM176 PF14851.6 EMC81781.1 - 0.4 10.3 2.4 0.71 9.5 0.6 2.1 2 0 0 2 2 2 0 FAM176 family zf-H2C2_2 PF13465.6 EMC81782.1 - 2.2e-13 50.0 22.8 1.2e-07 31.9 2.4 4.3 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 EMC81782.1 - 2.7e-13 49.6 28.1 2e-05 24.8 2.2 4.1 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC81782.1 - 8e-06 26.3 30.3 0.00081 20.0 1.8 3.8 4 0 0 4 4 4 3 C2H2-type zinc finger zf-Di19 PF05605.12 EMC81782.1 - 0.0089 16.3 2.2 0.0089 16.3 2.2 2.8 1 1 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 EMC81782.1 - 0.013 15.4 15.3 0.15 12.1 1.4 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EMC81782.1 - 0.12 12.7 6.5 0.13 12.6 4.8 2.0 2 0 0 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 EMC81782.1 - 0.14 12.5 4.8 1.7 9.1 1.2 3.0 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf_C2H2_ZHX PF18387.1 EMC81782.1 - 0.27 10.9 2.3 4.2 7.1 0.7 2.5 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain MHC_II_beta PF00969.19 EMC81784.1 - 4.8e-34 116.3 0.1 7.7e-34 115.6 0.1 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.15 EMC81784.1 - 3.6e-27 94.6 0.7 5.2e-27 94.0 0.7 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.6 EMC81784.1 - 9.9e-07 29.3 0.4 1.6e-06 28.6 0.4 1.3 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC81784.1 - 0.00012 22.2 0.2 0.0002 21.5 0.2 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC81784.1 - 0.0016 18.8 0.2 0.0024 18.2 0.2 1.3 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 EMC81784.1 - 0.002 18.2 0.3 0.0038 17.3 0.3 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain DUF4448 PF14610.6 EMC81784.1 - 0.0035 17.2 0.0 0.0046 16.7 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF4448) I-set PF07679.16 EMC81784.1 - 0.01 15.9 0.1 0.017 15.2 0.1 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain Marek_A PF02124.15 EMC81784.1 - 0.025 14.4 0.0 0.031 14.1 0.0 1.2 1 0 0 1 1 1 0 Marek's disease glycoprotein A Cna_B PF05738.13 EMC81784.1 - 0.04 14.5 0.1 0.068 13.7 0.1 1.3 1 0 0 1 1 1 0 Cna protein B-type domain MHC_I PF00129.18 EMC81784.1 - 0.079 12.5 0.1 0.12 11.9 0.1 1.3 1 0 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 SK_channel PF03530.14 EMC81784.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Calcium-activated SK potassium channel 7tm_4 PF13853.6 EMC81785.1 - 3.2e-25 89.4 5.9 4.3e-25 89.0 5.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC81785.1 - 2.8e-15 56.3 7.5 4.3e-15 55.7 7.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) F-box-like PF12937.7 EMC81787.1 - 6.5e-09 35.5 5.6 1.4e-08 34.5 5.6 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMC81787.1 - 4.7e-08 32.7 2.8 1.2e-07 31.5 2.8 1.6 1 0 0 1 1 1 1 F-box domain Radical_SAM_C PF16199.5 EMC81788.1 - 1.2e-34 118.1 0.0 2.1e-34 117.4 0.0 1.4 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 EMC81788.1 - 4.3e-22 79.3 0.4 5.8e-21 75.6 0.1 2.6 3 0 0 3 3 3 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 EMC81788.1 - 3.2e-10 40.3 0.1 6e-10 39.4 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMC81788.1 - 3.4e-05 23.8 0.1 7.6e-05 22.7 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMC81788.1 - 0.11 12.5 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein Pkinase PF00069.25 EMC81789.1 - 3.2e-48 164.4 0.0 1.2e-47 162.5 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81789.1 - 2.9e-35 121.8 0.2 2.5e-26 92.5 0.0 2.6 1 1 1 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 EMC81789.1 - 0.0013 18.2 0.0 0.0028 17.1 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-NADH-PPase PF09297.11 EMC81789.1 - 0.0032 17.1 2.2 0.96 9.2 0.0 2.6 2 0 0 2 2 2 2 NADH pyrophosphatase zinc ribbon domain APH PF01636.23 EMC81789.1 - 0.016 15.2 0.2 0.33 10.8 0.2 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family ABC1 PF03109.16 EMC81789.1 - 0.03 14.5 0.0 0.053 13.7 0.0 1.3 1 0 0 1 1 1 0 ABC1 family RIO1 PF01163.22 EMC81789.1 - 0.062 12.9 0.0 0.19 11.3 0.0 1.7 2 0 0 2 2 2 0 RIO1 family YrbL-PhoP_reg PF10707.9 EMC81789.1 - 0.068 12.7 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Opiods_neuropep PF01160.18 EMC81790.1 - 2.1e-14 53.3 3.1 3.5e-14 52.6 3.1 1.3 1 0 0 1 1 1 1 Vertebrate endogenous opioids neuropeptide DUF1272 PF06906.11 EMC81790.1 - 0.044 13.9 1.3 0.07 13.2 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) PAS_11 PF14598.6 EMC81791.1 - 8.3e-27 93.6 0.0 9.4e-27 93.4 0.0 1.0 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.12 EMC81791.1 - 0.046 14.0 0.0 0.059 13.7 0.0 1.3 1 1 0 1 1 1 0 PAS fold DUF1518 PF07469.12 EMC81792.1 - 1.1e-33 115.3 41.1 1.9e-20 73.0 19.9 3.8 4 0 0 4 4 4 2 Domain of unknown function (DUF1518) CENP-O PF09496.10 EMC81793.1 - 2.6e-10 40.6 0.8 2.6e-10 40.6 0.8 2.2 1 1 1 2 2 2 1 Cenp-O kinetochore centromere component DASH_Spc19 PF08287.11 EMC81793.1 - 0.0075 16.2 4.2 0.0075 16.2 4.2 1.6 2 0 0 2 2 2 1 Spc19 Spc7 PF08317.11 EMC81793.1 - 0.01 14.8 4.2 0.014 14.3 4.2 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DivIC PF04977.15 EMC81793.1 - 0.059 13.1 10.6 0.13 12.1 10.6 1.6 1 0 0 1 1 1 0 Septum formation initiator HAUS6_N PF14661.6 EMC81793.1 - 0.75 9.3 7.5 0.49 9.9 5.7 1.5 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus DUF5403 PF17395.2 EMC81793.1 - 1.1 9.6 3.2 0.76 10.1 1.3 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5403) Ras PF00071.22 EMC81794.1 - 4.1e-42 143.5 0.1 5.3e-42 143.2 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC81794.1 - 1.4e-24 86.6 0.0 4e-24 85.1 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC81794.1 - 1.3e-15 57.3 0.0 1.8e-15 56.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DnaJ PF00226.31 EMC81794.1 - 4e-12 46.1 0.0 7.5e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain MMR_HSR1 PF01926.23 EMC81794.1 - 1.3e-05 25.3 0.0 3.3e-05 23.9 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMC81794.1 - 5.3e-05 22.7 0.0 6.7e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EMC81794.1 - 0.00038 20.1 0.1 0.0011 18.5 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EMC81794.1 - 0.046 13.6 0.0 3.9 7.4 0.0 2.8 1 1 2 3 3 3 0 RsgA GTPase FeoB_N PF02421.18 EMC81794.1 - 0.096 12.2 0.0 0.61 9.6 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B ACTH_domain PF00976.18 EMC81797.1 - 2.8e-24 84.6 31.8 1.7e-08 34.2 4.3 3.5 4 0 0 4 4 4 3 Corticotropin ACTH domain Op_neuropeptide PF08035.11 EMC81797.1 - 1.4e-14 53.6 0.0 2.8e-14 52.7 0.0 1.5 1 0 0 1 1 1 1 Opioids neuropeptide NPP PF08384.10 EMC81797.1 - 3.9e-08 33.2 0.2 6.8e-08 32.4 0.2 1.4 1 0 0 1 1 1 1 Pro-opiomelanocortin, N-terminal region Fibrinogen_C PF00147.18 EMC81798.1 - 1.4e-43 149.3 0.5 1.6e-43 149.1 0.5 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Stathmin PF00836.19 EMC81799.1 - 1.1e-58 197.1 20.2 1.3e-58 196.8 20.2 1.1 1 0 0 1 1 1 1 Stathmin family Pex19 PF04614.12 EMC81799.1 - 0.0043 16.9 6.8 0.0051 16.6 6.8 1.1 1 0 0 1 1 1 1 Pex19 protein family Exonuc_VII_L PF02601.15 EMC81799.1 - 0.47 10.0 8.0 0.51 9.9 8.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.9 EMC81799.1 - 0.84 8.7 15.6 1.1 8.3 15.6 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Ribonuc_2-5A PF06479.12 EMC81799.1 - 2.6 8.2 9.9 10 6.3 9.9 1.8 1 1 0 1 1 1 0 Ribonuclease 2-5A EF-hand_14 PF17959.1 EMC81799.1 - 7.6 7.0 8.5 1.4 9.3 2.3 2.2 1 1 1 2 2 2 0 EF-hand domain PRY PF13765.6 EMC81800.1 - 7e-15 54.4 0.0 1.4e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 SPRY-associated domain zf-RING_UBOX PF13445.6 EMC81800.1 - 8.1e-09 35.4 8.1 8.1e-09 35.4 8.1 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-B_box PF00643.24 EMC81800.1 - 1.2e-08 34.9 2.9 1.2e-08 34.9 2.9 2.9 2 1 0 2 2 2 1 B-box zinc finger zf-C3HC4_3 PF13920.6 EMC81800.1 - 7.3e-08 32.2 11.6 7.3e-08 32.2 11.6 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC81800.1 - 9.3e-08 31.8 13.8 2.6e-07 30.4 13.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMC81800.1 - 1.9e-07 31.1 13.1 1.9e-07 31.1 13.1 2.9 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 EMC81800.1 - 8.4e-07 28.8 13.8 8.4e-07 28.8 13.8 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC81800.1 - 1.2e-06 28.7 15.2 1.2e-06 28.7 15.2 2.1 2 0 0 2 2 1 1 Ring finger domain SPRY PF00622.28 EMC81800.1 - 1.6e-06 28.2 0.0 3.4e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 SPRY domain zf-RING_6 PF14835.6 EMC81800.1 - 4.6e-06 26.4 3.4 9.1e-06 25.5 3.4 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.6 EMC81800.1 - 3e-05 23.9 14.0 3e-05 23.9 14.0 2.0 2 0 0 2 2 2 1 zinc-RING finger domain Baculo_IE-1 PF05290.11 EMC81800.1 - 0.00047 20.1 5.0 0.00087 19.3 5.0 1.4 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-CHC2 PF01807.20 EMC81800.1 - 0.0073 16.1 0.2 0.0073 16.1 0.2 1.7 1 1 0 1 1 1 1 CHC2 zinc finger U-box PF04564.15 EMC81800.1 - 0.025 14.7 0.0 0.042 14.0 0.0 1.3 1 0 0 1 1 1 0 U-box domain FixS PF03597.15 EMC81800.1 - 0.41 10.4 1.8 1.1 9.0 1.8 1.6 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type zf-rbx1 PF12678.7 EMC81800.1 - 2.1 8.7 17.5 0.26 11.6 11.0 2.5 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 EMC81800.1 - 6.2 6.7 18.3 0.71 9.7 12.3 2.5 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 EMC81800.1 - 7.4 6.5 20.3 0.38 10.6 13.5 2.4 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 EMC81800.1 - 8 6.7 12.4 0.35 11.0 6.4 1.9 2 0 0 2 2 2 0 zinc RING finger of MSL2 NYD-SP28 PF14772.6 EMC81801.1 - 2.8e-29 101.1 16.1 2.8e-29 101.1 16.1 5.4 3 1 2 5 5 5 1 Sperm tail NYD-SP28_assoc PF14775.6 EMC81801.1 - 1.4e-20 73.2 0.6 1.4e-20 73.2 0.6 4.0 3 2 1 4 4 4 1 Sperm tail C-terminal domain Peptidase_M41 PF01434.18 EMC81801.1 - 3.6 7.4 11.7 0.17 11.7 0.4 3.2 1 1 2 3 3 3 0 Peptidase family M41 Baculo_PEP_C PF04513.12 EMC81801.1 - 5.8 7.0 18.7 2.3 8.3 2.3 3.7 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Hormone_recep PF00104.30 EMC81802.1 - 2.9e-08 33.6 0.2 3.1e-08 33.4 0.2 1.0 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Pro_isomerase PF00160.21 EMC81803.1 - 6.3e-47 159.8 0.2 7e-47 159.6 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD CNDH2_M PF16869.5 EMC81804.1 - 0.3 11.8 2.7 1.8 9.2 2.7 2.0 1 1 0 1 1 1 0 PF16858 RhoGEF67_u2 PF16614.5 EMC81805.1 - 1.5e-50 169.8 4.4 1.5e-50 169.8 4.4 2.7 2 1 0 2 2 2 1 Unstructured region two on RhoGEF 6 and 7 betaPIX_CC PF16523.5 EMC81805.1 - 3.3e-41 139.0 10.1 3.3e-41 139.0 10.1 3.4 4 0 0 4 4 4 1 betaPIX coiled coil RhoGEF PF00621.20 EMC81805.1 - 9.9e-31 107.4 1.5 9.9e-31 107.4 1.5 2.1 2 0 0 2 2 2 1 RhoGEF domain SH3_2 PF07653.17 EMC81805.1 - 5.5e-18 64.4 0.3 1.2e-17 63.4 0.3 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EMC81805.1 - 1.5e-17 63.1 0.1 3e-17 62.2 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC81805.1 - 1.2e-16 60.0 0.1 2.2e-16 59.2 0.1 1.5 1 0 0 1 1 1 1 SH3 domain RhoGEF67_u1 PF16615.5 EMC81805.1 - 3.4e-16 59.5 2.6 3.4e-16 59.5 2.6 3.5 4 0 0 4 4 3 1 Unstructured region one on RhoGEF 6 and 7 PH PF00169.29 EMC81805.1 - 1.8e-08 34.9 0.0 4.5e-08 33.5 0.0 1.7 1 0 0 1 1 1 1 PH domain AKNA PF12443.8 EMC81805.1 - 0.061 14.0 5.0 0.64 10.7 0.1 3.3 2 0 0 2 2 2 0 AT-hook-containing transcription factor TCTP PF00838.17 EMC81805.1 - 0.17 12.2 4.0 1 9.7 0.9 2.6 2 0 0 2 2 2 0 Translationally controlled tumour protein GlutR_dimer PF00745.20 EMC81805.1 - 0.19 12.2 3.5 0.71 10.4 3.5 2.0 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain CENP-Q PF13094.6 EMC81805.1 - 0.6 10.3 13.2 0.79 9.9 4.7 3.4 3 0 0 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit FCH PF00611.23 EMC81805.1 - 3 8.2 8.8 0.31 11.4 0.7 3.2 3 0 0 3 3 3 0 Fes/CIP4, and EFC/F-BAR homology domain Ank_2 PF12796.7 EMC81806.1 - 2.4e-24 85.7 0.6 1.3e-12 48.1 0.3 2.5 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC81806.1 - 8.5e-16 58.1 1.2 1e-07 32.3 0.1 3.5 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC81806.1 - 8.4e-12 45.1 0.3 1.1e-06 28.8 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EMC81806.1 - 2.2e-11 43.7 0.7 0.00032 21.0 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 EMC81806.1 - 3.6e-09 36.1 0.0 0.0055 17.1 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat MAGI_u1 PF16663.5 EMC81806.1 - 0.022 14.8 0.2 0.058 13.5 0.2 1.7 1 0 0 1 1 1 0 Unstructured region on MAGI ING PF12998.7 EMC81807.1 - 3e-30 104.8 5.2 3e-30 104.8 5.2 2.0 2 1 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EMC81807.1 - 1.8e-06 27.7 8.4 4.6e-06 26.4 8.4 1.7 1 0 0 1 1 1 1 PHD-finger SRP-alpha_N PF04086.13 EMC81807.1 - 0.0018 18.2 12.5 0.0028 17.6 12.5 1.2 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal PHD_2 PF13831.6 EMC81807.1 - 0.013 15.1 3.1 0.024 14.2 3.1 1.4 1 0 0 1 1 1 0 PHD-finger DUF4661 PF15576.6 EMC81807.1 - 0.022 14.7 3.5 0.032 14.1 3.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) ZYG-11_interact PF05884.12 EMC81807.1 - 0.06 12.7 0.5 0.088 12.2 0.5 1.2 1 0 0 1 1 1 0 Interactor of ZYG-11 SF3A3 PF16837.5 EMC81807.1 - 0.09 13.3 0.3 0.2 12.2 0.3 1.5 1 0 0 1 1 1 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 zf-HC5HC2H PF13771.6 EMC81807.1 - 0.092 13.0 3.0 0.41 10.9 2.9 2.3 1 1 0 1 1 1 0 PHD-like zinc-binding domain CDC45 PF02724.14 EMC81807.1 - 0.27 9.5 9.1 0.27 9.5 9.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Virul_Fac PF10139.9 EMC81807.1 - 0.96 7.6 9.8 1.3 7.2 9.8 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor ALMT PF11744.8 EMC81807.1 - 2.1 7.1 8.6 2.8 6.7 8.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter zf-C4pol PF14260.6 EMC81807.1 - 2.2 8.8 10.6 5.4 7.5 0.9 3.6 3 1 0 3 3 3 0 C4-type zinc-finger of DNA polymerase delta RR_TM4-6 PF06459.12 EMC81807.1 - 2.7 7.8 12.3 4 7.2 12.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 EMC81807.1 - 3.3 6.8 4.1 3.7 6.7 4.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 EMC81807.1 - 3.9 6.2 11.3 5.3 5.7 11.3 1.2 1 0 0 1 1 1 0 Presenilin LRR_8 PF13855.6 EMC81808.1 - 1.8e-13 50.0 0.0 1.9e-06 27.5 0.1 2.4 1 1 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EMC81808.1 - 2.3e-09 37.3 0.0 3.6e-06 27.2 0.0 2.7 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC81808.1 - 0.00014 21.9 0.0 5.7 7.9 0.0 3.4 3 0 0 3 3 3 2 Leucine Rich Repeat LRR_6 PF13516.6 EMC81808.1 - 0.0002 21.2 0.0 0.63 10.2 0.0 3.2 3 0 0 3 3 3 2 Leucine Rich repeat Trypsin PF00089.26 EMC81809.1 - 7.9e-62 208.9 0.2 8.9e-62 208.8 0.2 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EMC81809.1 - 1.8e-07 32.2 0.0 2.4e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 EMC81809.1 - 0.0016 18.8 0.0 0.0033 17.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin PF00089.26 EMC81811.1 - 6.1e-73 245.3 0.3 7.4e-73 245.0 0.3 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 EMC81811.1 - 1.2e-06 28.8 0.0 0.017 15.5 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 EMC81811.1 - 1.6e-05 25.9 0.0 2.3e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain TMEM135_C_rich PF15982.5 EMC81812.1 - 3.9e-44 150.5 1.3 3.9e-44 150.5 1.3 2.0 2 0 0 2 2 2 1 N-terminal cysteine-rich region of Transmembrane protein 135 Tim17 PF02466.19 EMC81812.1 - 4.9e-08 33.3 0.2 1.8e-07 31.5 0.0 2.0 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family Frizzled PF01534.17 EMC81813.1 - 8.8e-126 419.3 23.9 2.4e-125 417.9 23.9 1.6 1 1 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 EMC81813.1 - 1.3e-13 51.6 1.3 2.6e-13 50.6 1.3 1.5 1 0 0 1 1 1 1 Fz domain DUF5083 PF16890.5 EMC81813.1 - 0.0073 16.1 0.4 0.014 15.2 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5083) Chol_subst-bind PF09129.11 EMC81813.1 - 0.077 11.9 0.6 0.27 10.2 0.0 1.9 1 1 1 2 2 2 0 Cholesterol oxidase, substrate-binding DUF3852 PF12963.7 EMC81813.1 - 7.3 7.0 9.3 0.83 10.0 2.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3852) Trypsin PF00089.26 EMC81814.1 - 1.2e-10 41.6 0.1 6.2e-10 39.3 0.1 2.2 1 1 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EMC81814.1 - 7e-08 33.5 0.0 1.2e-07 32.7 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain FB_lectin PF07367.11 EMC81814.1 - 0.037 14.0 0.3 2.5 8.0 0.0 2.2 2 0 0 2 2 2 0 Fungal fruit body lectin Glyco_hydr_116N PF12215.8 EMC81814.1 - 0.072 12.6 0.2 0.1 12.0 0.2 1.2 1 0 0 1 1 1 0 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term Malic_M PF03949.15 EMC81815.1 - 6e-103 343.6 0.2 7.5e-103 343.3 0.2 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EMC81815.1 - 4.4e-80 267.8 0.0 6.4e-80 267.2 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Peptidase_S28 PF05577.12 EMC81816.1 - 5.5e-98 328.6 0.0 6.4e-98 328.4 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S37 PF05576.11 EMC81816.1 - 0.0013 17.5 0.0 0.0025 16.6 0.0 1.4 2 0 0 2 2 2 1 PS-10 peptidase S37 Hydrolase_4 PF12146.8 EMC81816.1 - 0.059 12.6 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Rep_fac-A_C PF08646.10 EMC81817.1 - 1.3e-10 41.2 0.1 2.3e-10 40.4 0.1 1.3 1 0 0 1 1 1 1 Replication factor-A C terminal domain Ribosomal_L40e PF01020.17 EMC81817.1 - 0.082 12.8 1.6 0.17 11.8 1.6 1.4 1 0 0 1 1 1 0 Ribosomal L40e family Ras PF00071.22 EMC81819.1 - 2.6e-58 196.2 0.0 3.2e-58 195.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC81819.1 - 1.4e-37 128.5 0.0 2.7e-37 127.6 0.0 1.4 2 0 0 2 2 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC81819.1 - 3.7e-15 55.8 0.0 4.8e-15 55.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EMC81819.1 - 4.3e-09 36.1 0.0 5.2e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMC81819.1 - 8.2e-06 25.9 0.0 1.2e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC81819.1 - 1.4e-05 25.1 0.3 0.042 13.7 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase ATP_bind_1 PF03029.17 EMC81819.1 - 1.5e-05 24.9 0.7 0.003 17.4 0.1 2.3 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 EMC81819.1 - 1.9e-05 24.3 0.0 0.00019 21.0 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA PF00004.29 EMC81819.1 - 0.0003 21.2 0.0 0.0016 18.8 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) FeoB_N PF02421.18 EMC81819.1 - 0.00087 18.8 0.3 0.0049 16.4 0.3 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 EMC81819.1 - 0.00088 18.8 0.0 0.0012 18.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_5 PF07728.14 EMC81819.1 - 0.0034 17.4 0.1 0.0087 16.1 0.1 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) PduV-EutP PF10662.9 EMC81819.1 - 0.0038 17.0 0.2 0.022 14.5 0.2 2.0 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 EMC81819.1 - 0.0055 16.7 0.4 0.092 12.8 0.0 2.4 2 1 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 EMC81819.1 - 0.008 16.6 0.1 0.015 15.7 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 EMC81819.1 - 0.0095 16.1 0.0 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EMC81819.1 - 0.01 15.8 0.1 0.023 14.6 0.1 1.6 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 EMC81819.1 - 0.012 15.9 0.2 0.035 14.4 0.1 1.9 2 1 0 2 2 2 0 AAA domain TIR_2 PF13676.6 EMC81819.1 - 0.038 14.6 0.1 0.048 14.3 0.1 1.2 1 0 0 1 1 1 0 TIR domain ABC_tran PF00005.27 EMC81819.1 - 0.078 13.5 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 ABC transporter cobW PF02492.19 EMC81819.1 - 0.083 12.5 0.3 13 5.4 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Mg_chelatase PF01078.21 EMC81819.1 - 0.1 12.0 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 EMC81819.1 - 0.1 12.3 0.1 0.13 11.9 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EMC81819.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 EMC81819.1 - 0.19 11.6 0.4 0.47 10.3 0.3 1.8 1 1 1 2 2 2 0 NTPase CTD_bind PF04818.13 EMC81820.1 - 1.3e-06 29.1 0.0 4.4e-06 27.4 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase II-binding domain. SHOCT PF09851.9 EMC81820.1 - 0.0026 17.4 0.9 0.013 15.2 0.2 2.4 2 0 0 2 2 2 1 Short C-terminal domain CFIA_Pcf11 PF11526.8 EMC81820.1 - 0.0038 17.7 0.1 0.0038 17.7 0.1 6.3 4 2 0 4 4 4 1 Subunit of cleavage factor IA Pcf11 DNA_pol3_a_NI PF14480.6 EMC81820.1 - 0.082 12.9 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus I Ank_2 PF12796.7 EMC81821.1 - 4.5e-50 168.2 13.6 7.7e-13 48.8 0.7 4.7 2 1 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC81821.1 - 1.3e-38 130.8 11.7 4.4e-09 36.7 0.1 6.5 3 2 4 7 7 7 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC81821.1 - 1.2e-27 95.6 9.1 1.7e-09 37.8 0.0 5.7 2 1 4 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 EMC81821.1 - 6.3e-26 89.6 10.3 5.3e-06 26.6 0.1 8.4 9 0 0 9 9 9 6 Ankyrin repeat Ank_3 PF13606.6 EMC81821.1 - 1.1e-22 77.6 7.5 0.0091 16.4 0.0 7.9 8 0 0 8 8 8 7 Ankyrin repeat DUF4129 PF13559.6 EMC81821.1 - 0.025 14.8 0.4 2.2 8.6 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4129) DUF2400 PF09674.10 EMC81821.1 - 0.064 13.2 0.4 5.3 7.0 1.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2400) Tmemb_cc2 PF10267.9 EMC81821.1 - 0.074 12.2 7.5 0.099 11.8 7.5 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DUF4845 PF16137.5 EMC81821.1 - 0.25 12.2 5.4 2.2 9.2 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4845) AAA_23 PF13476.6 EMC81821.1 - 2 8.8 10.3 4.2 7.8 10.3 1.5 1 0 0 1 1 1 0 AAA domain HTH_37 PF13744.6 EMC81821.1 - 3.2 7.8 6.5 1.3 9.0 0.4 2.4 1 1 1 2 2 2 0 Helix-turn-helix domain DUF1640 PF07798.11 EMC81822.1 - 3.6e-60 203.0 15.5 5.6e-60 202.4 15.5 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1640) Vac_Fusion PF02346.16 EMC81822.1 - 0.062 12.9 2.5 0.15 11.7 0.2 2.8 2 2 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 HALZ PF02183.18 EMC81822.1 - 0.21 11.8 2.1 0.31 11.3 1.0 1.8 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF2408 PF10303.9 EMC81822.1 - 0.44 11.1 7.3 1.7 9.2 7.3 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) IZUMO PF15005.6 EMC81822.1 - 0.91 10.0 6.7 1.6 9.3 6.3 1.6 1 1 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated YabA PF06156.13 EMC81822.1 - 3.7 8.2 11.3 0.91 10.2 4.2 2.3 1 1 1 2 2 2 0 Initiation control protein YabA PDZ PF00595.24 EMC81823.1 - 6.7e-22 77.6 0.6 8.3e-22 77.3 0.6 1.1 1 0 0 1 1 1 1 PDZ domain PDZ_assoc PF10600.9 EMC81823.1 - 2.1e-16 60.5 0.5 2.8e-16 60.1 0.5 1.2 1 0 0 1 1 1 1 PDZ-associated domain of NMDA receptors PDZ_6 PF17820.1 EMC81823.1 - 1.4e-12 47.2 0.2 2e-12 46.8 0.2 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC81823.1 - 7.1e-06 26.3 0.1 9.9e-06 25.8 0.1 1.2 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 EMC81824.1 - 2.5e-45 152.7 2.2 7.1e-22 77.6 0.2 2.0 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 EMC81824.1 - 6.2e-19 67.6 0.6 7.1e-09 35.4 0.1 2.2 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 EMC81824.1 - 6.1e-12 45.7 0.5 1.5e-05 25.2 0.0 2.1 2 0 0 2 2 2 2 PDZ domain PDZ_assoc PF10600.9 EMC81824.1 - 0.00022 22.0 0.7 0.00052 20.8 0.7 1.7 2 0 0 2 2 2 1 PDZ-associated domain of NMDA receptors DUF1285 PF06938.11 EMC81824.1 - 0.13 12.3 0.0 3.8 7.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1285) L27_1 PF09058.10 EMC81825.1 - 1.8e-17 63.0 0.1 3.1e-17 62.3 0.1 1.4 1 0 0 1 1 1 1 L27_1 TMEM126 PF07114.11 EMC81826.1 - 8.1e-76 253.4 0.4 9.9e-76 253.1 0.4 1.0 1 0 0 1 1 1 1 Transmembrane protein 126 DsbB PF02600.16 EMC81826.1 - 0.13 12.7 3.4 0.25 11.8 2.8 1.8 1 1 0 1 1 1 0 Disulfide bond formation protein DsbB ANTH PF07651.16 EMC81827.1 - 5.1e-82 275.0 0.7 7.1e-82 274.5 0.7 1.2 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 EMC81827.1 - 8.6e-13 48.4 0.1 1.8e-12 47.4 0.1 1.5 1 0 0 1 1 1 1 ENTH domain WD40 PF00400.32 EMC81828.1 - 2.1e-11 44.2 8.1 1.1e-05 26.1 0.0 5.0 6 0 0 6 6 6 3 WD domain, G-beta repeat Nup160 PF11715.8 EMC81828.1 - 0.0023 16.6 0.0 0.0086 14.8 0.0 1.9 2 0 0 2 2 2 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EMC81828.1 - 0.0026 18.0 0.4 13 6.2 0.0 4.4 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Lipoprotein_3 PF00938.17 EMC81828.1 - 0.17 12.1 0.0 0.4 10.9 0.0 1.6 1 0 0 1 1 1 0 Lipoprotein DUF775 PF05603.12 EMC81829.1 - 7.9e-57 192.0 0.4 1.2e-56 191.5 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF775) MRAP PF15183.6 EMC81830.1 - 4.2e-34 116.4 0.1 6.6e-34 115.7 0.1 1.2 1 0 0 1 1 1 1 Melanocortin-2 receptor accessory protein family DUF2553 PF10830.8 EMC81831.1 - 3.2 8.6 8.7 0.68 10.8 1.9 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2553) T-box PF00907.22 EMC81832.1 - 1.4e-80 269.9 0.0 4.1e-80 268.4 0.0 1.7 2 0 0 2 2 2 1 T-box 5_nucleotid_C PF02872.18 EMC81833.1 - 3.1e-41 141.2 0.0 5.6e-41 140.4 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 EMC81833.1 - 0.0019 18.7 0.0 0.0036 17.8 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PXA PF02194.15 EMC81834.1 - 8.7e-38 130.1 0.3 2.7e-37 128.5 0.3 1.9 1 0 0 1 1 1 1 PXA domain PX PF00787.24 EMC81834.1 - 2.2e-20 72.7 1.1 2.2e-20 72.7 1.1 2.8 3 0 0 3 3 3 1 PX domain Nexin_C PF08628.12 EMC81834.1 - 1.2e-14 54.8 0.0 4.6e-14 52.9 0.0 2.1 1 0 0 1 1 1 1 Sorting nexin C terminal RGS PF00615.19 EMC81834.1 - 4.5e-12 46.3 4.1 7.3e-12 45.6 1.8 2.5 2 0 0 2 2 2 1 Regulator of G protein signaling domain dDENN PF03455.19 EMC81834.1 - 0.23 11.5 3.8 3.7 7.6 0.4 3.9 4 0 0 4 4 4 0 dDENN domain 7tm_1 PF00001.21 EMC81835.1 - 3.2e-74 249.6 12.6 4.1e-74 249.2 12.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC81835.1 - 2.5e-08 33.9 16.6 4.4e-08 33.1 16.6 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 EMC81835.1 - 6.3e-07 29.0 14.0 1.6e-06 27.7 14.0 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC81835.1 - 4.1e-05 23.5 13.2 0.00059 19.7 13.2 2.1 1 1 0 1 1 1 1 Olfactory receptor Hormone_6 PF00236.18 EMC81836.1 - 6.9e-53 176.6 8.9 8e-53 176.4 8.9 1.0 1 0 0 1 1 1 1 Glycoprotein hormone NARG2_C PF10505.9 EMC81836.1 - 0.061 12.8 0.0 0.095 12.2 0.0 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated gene protein 2 C-terminus PDGF PF00341.17 EMC81836.1 - 0.072 13.4 8.9 0.13 12.6 8.9 1.5 1 1 0 1 1 1 0 PDGF/VEGF domain Connexin PF00029.19 EMC81837.1 - 1.1e-76 257.7 13.6 1.1e-43 149.7 0.6 2.0 1 1 1 2 2 2 2 Connexin Alpha_kinase PF02816.18 EMC81838.1 - 1 9.5 5.8 0.48 10.5 3.3 1.7 1 1 0 1 1 1 0 Alpha-kinase family Adaptin_binding PF10199.9 EMC81838.1 - 6.2 7.4 17.1 1.4e+02 3.1 17.1 2.5 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 FlgT_N PF16548.5 EMC81838.1 - 6.9 7.3 12.2 11 6.7 1.0 3.0 3 1 0 3 3 3 0 Flagellar assembly protein T, N-terminal domain Nuc_sug_transp PF04142.15 EMC81839.1 - 2.5e-105 352.1 16.6 2.8e-105 352.0 16.6 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 EMC81839.1 - 1.5e-05 24.4 16.2 2.1e-05 23.9 15.5 1.4 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 EMC81839.1 - 0.00019 21.6 24.7 0.0074 16.5 1.0 2.1 2 0 0 2 2 2 2 EamA-like transporter family DUF202 PF02656.15 EMC81839.1 - 0.14 12.6 0.2 0.14 12.6 0.2 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF202) tRNA-synt_1d PF00750.19 EMC81840.1 - 7.7e-89 298.0 3.5 1.2e-88 297.5 3.5 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EMC81840.1 - 3.6e-20 72.3 0.6 3.6e-20 72.3 0.6 2.1 2 0 0 2 2 2 1 DALR anticodon binding domain tRNA-synt_1g PF09334.11 EMC81840.1 - 0.027 13.2 0.4 1 8.1 0.1 2.3 1 1 1 2 2 2 0 tRNA synthetases class I (M) DUF3631 PF12307.8 EMC81840.1 - 0.035 14.3 0.0 0.11 12.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3631) ORC3_N PF07034.11 EMC81841.1 - 5.5e-130 433.3 7.9 5.5e-130 433.3 7.9 1.7 2 0 0 2 2 2 1 Origin recognition complex (ORC) subunit 3 N-terminus ORC_WH_C PF18137.1 EMC81841.1 - 8.9e-30 103.6 0.0 8.2e-28 97.2 0.0 2.8 1 1 0 1 1 1 1 Origin recognition complex winged helix C-terminal Vac14_Fab1_bd PF12755.7 EMC81841.1 - 0.088 13.4 0.0 1.8 9.2 0.0 2.9 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region DUF2935 PF11155.8 EMC81841.1 - 5.9 7.2 7.8 3.4 8.0 0.4 3.5 3 2 0 3 3 3 0 Domain of unknown function (DUF2935) TAFH PF07531.14 EMC81841.1 - 9.3 6.4 8.2 2.7 8.1 0.0 3.8 4 0 0 4 4 4 0 NHR1 homology to TAF PET10 PF17316.2 EMC81842.1 - 0.036 13.6 0.0 0.046 13.2 0.0 1.2 1 0 0 1 1 1 0 Petite colonies protein 10 DUF885 PF05960.11 EMC81842.1 - 0.059 13.0 0.1 0.063 12.9 0.1 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) DUF930 PF06059.12 EMC81843.1 - 0.063 13.8 0.0 0.081 13.5 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF930) Sec61_beta PF03911.16 EMC81843.1 - 3.1 7.9 7.2 1 9.5 4.3 1.8 1 1 0 1 1 1 0 Sec61beta family 7tm_1 PF00001.21 EMC81844.1 - 2.1e-45 155.1 16.8 3.1e-45 154.5 16.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC81844.1 - 2e-12 47.1 16.9 2.9e-12 46.5 16.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC81844.1 - 1.1e-09 38.4 13.7 1.5e-05 24.9 6.2 2.5 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC81844.1 - 3.5e-07 30.1 9.5 3.5e-07 30.1 9.5 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx YlaC PF10777.9 EMC81844.1 - 0.046 13.6 4.0 0.1 12.4 0.3 2.6 3 0 0 3 3 3 0 Inner membrane protein YlaC mRNA_cap_C PF03919.15 EMC81845.1 - 4.1e-17 62.8 0.2 5.1e-17 62.5 0.2 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain V-set PF07686.17 EMC81846.1 - 1.1e-06 28.8 0.0 1.3e-06 28.5 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC81846.1 - 0.027 15.1 0.0 0.085 13.5 0.0 1.6 1 1 0 1 1 1 0 Immunoglobulin domain UCH PF00443.29 EMC81847.1 - 1.9e-16 60.3 0.3 3.3e-16 59.6 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMC81847.1 - 2.9e-05 23.8 6.3 7.1e-05 22.6 6.3 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Sad1_UNC PF07738.13 EMC81848.1 - 4.6e-37 127.0 0.0 6.6e-37 126.5 0.0 1.1 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal DUF5000 PF16391.5 EMC81848.1 - 0.045 13.9 0.0 0.13 12.4 0.0 1.7 1 1 1 2 2 2 0 Domain of unknown function 7tm_4 PF13853.6 EMC81849.1 - 4.5e-20 72.5 0.2 5.4e-20 72.3 0.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC81849.1 - 0.00011 21.7 1.7 0.00015 21.2 1.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TMEMspv1-c74-12 PF11044.8 EMC81849.1 - 0.00055 19.9 1.7 0.0044 17.0 1.0 2.2 2 0 0 2 2 2 1 Plectrovirus spv1-c74 ORF 12 transmembrane protein NhaB PF06450.12 EMC81849.1 - 0.0073 15.2 0.5 0.0085 15.0 0.5 1.1 1 0 0 1 1 1 1 Bacterial Na+/H+ antiporter B (NhaB) VWD PF00094.25 EMC81850.1 - 6.1e-11 42.8 2.9 1.1e-10 42.0 2.9 1.4 1 0 0 1 1 1 1 von Willebrand factor type D domain TILa PF12714.7 EMC81850.1 - 3.6e-10 39.6 13.6 3.6e-10 39.6 13.6 1.8 1 1 0 1 1 1 1 TILa domain MLANA PF14991.6 EMC81851.1 - 0.00072 19.8 0.0 0.00084 19.6 0.0 1.2 1 0 0 1 1 1 1 Protein melan-A Adeno_E3_CR2 PF02439.15 EMC81851.1 - 0.018 14.8 1.1 0.029 14.1 1.1 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 EphA2_TM PF14575.6 EMC81851.1 - 0.056 14.3 0.0 0.06 14.2 0.0 1.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain V-set PF07686.17 EMC81852.1 - 0.00014 22.0 0.0 0.0005 20.2 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.16 EMC81852.1 - 0.00082 19.4 0.0 1.3 9.1 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC81852.1 - 0.0024 18.5 0.1 0.2 12.3 0.1 2.4 2 1 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 EMC81852.1 - 0.031 14.5 0.1 0.15 12.2 0.1 2.0 2 1 0 2 2 2 0 Immunoglobulin domain Ig_2 PF13895.6 EMC81852.1 - 0.056 13.8 0.0 0.28 11.6 0.1 1.9 2 0 0 2 2 2 0 Immunoglobulin domain Ets PF00178.22 EMC81855.1 - 1.4e-34 118.4 2.3 1.7e-34 118.1 2.3 1.1 1 0 0 1 1 1 1 Ets-domain PH_16 PF17838.1 EMC81856.1 - 1.2e-42 144.7 1.5 1.6e-42 144.3 0.1 1.9 2 0 0 2 2 2 1 PH domain RhoGEF PF00621.20 EMC81856.1 - 2.9e-37 128.7 4.7 5.2e-37 127.8 4.7 1.4 1 0 0 1 1 1 1 RhoGEF domain DUF3672 PF12421.8 EMC81858.1 - 0.1 12.5 0.3 5.3 7.0 0.0 2.8 1 1 2 3 3 3 0 Fibronectin type III protein PT PF04886.12 EMC81859.1 - 2.1e-06 27.1 19.3 0.037 13.6 0.8 5.2 2 1 3 5 5 5 4 PT repeat GST_N_4 PF17172.4 EMC81860.1 - 2.1e-32 111.8 0.0 3.9e-32 110.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 EMC81860.1 - 7.2e-19 67.3 0.0 1.3e-18 66.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 EMC81860.1 - 8.4e-15 55.2 0.1 1.9e-14 54.0 0.0 1.6 2 0 0 2 2 2 1 Outer mitochondrial membrane transport complex protein GST_C_2 PF13410.6 EMC81860.1 - 3.8e-05 23.6 0.0 8e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EMC81860.1 - 0.0064 16.9 0.0 0.1 13.0 0.0 2.6 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Methyltransf_23 PF13489.6 EMC81861.1 - 8e-20 71.3 0.0 1.1e-19 70.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC81861.1 - 1.8e-18 67.0 0.0 4.4e-18 65.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC81861.1 - 1.8e-14 54.3 0.0 3e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC81861.1 - 9.8e-14 51.8 0.0 1.9e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC81861.1 - 2.3e-12 47.0 0.0 3.3e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EMC81861.1 - 1.3e-07 31.2 0.0 1.7e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 EMC81861.1 - 7.7e-06 25.5 0.0 1.1e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 EMC81861.1 - 5.7e-05 22.6 0.0 9.7e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family NodS PF05401.11 EMC81861.1 - 0.00015 21.4 0.0 0.00021 21.0 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) MTS PF05175.14 EMC81861.1 - 0.00022 20.8 0.0 0.00041 19.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_9 PF08003.11 EMC81861.1 - 0.00079 18.4 0.0 0.0012 17.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_16 PF10294.9 EMC81861.1 - 0.0024 17.6 0.0 0.0043 16.8 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase TehB PF03848.14 EMC81861.1 - 0.0092 15.4 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_PK PF05891.12 EMC81861.1 - 0.015 14.8 0.0 0.021 14.4 0.0 1.2 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase PNISR PF15996.5 EMC81862.1 - 1.3e-53 182.4 25.0 1.3e-53 182.4 25.0 6.1 2 2 3 5 5 5 1 Arginine/serine-rich protein PNISR UCH PF00443.29 EMC81863.1 - 3.8e-46 157.7 1.1 5.6e-46 157.1 1.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EMC81863.1 - 7.7e-18 64.6 5.9 7.7e-18 64.6 5.9 2.6 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein THOC7 PF05615.13 EMC81863.1 - 0.016 15.5 1.4 0.25 11.6 0.2 2.7 2 0 0 2 2 2 0 Tho complex subunit 7 zinc_ribbon_9 PF14369.6 EMC81863.1 - 5.6 7.3 6.5 2.5 8.4 0.8 3.0 3 0 0 3 3 3 0 zinc-ribbon Cyclin_N PF00134.23 EMC81864.1 - 2.4e-14 53.2 3.7 7.9e-13 48.3 0.7 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 EMC81864.1 - 5.9e-07 29.8 0.3 2.2e-06 28.0 0.3 2.0 1 1 0 1 1 1 1 Cyclin C-terminal domain TFIIB PF00382.19 EMC81864.1 - 0.007 16.4 0.1 0.11 12.6 0.0 2.2 2 0 0 2 2 2 1 Transcription factor TFIIB repeat Cyclin_C PF02984.19 EMC81864.1 - 0.0081 16.2 0.7 0.065 13.3 0.1 2.5 2 1 1 3 3 3 1 Cyclin, C-terminal domain 7tm_1 PF00001.21 EMC81865.1 - 4.2e-45 154.1 21.5 5.1e-45 153.8 21.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC81865.1 - 3.8e-08 33.4 11.4 4e-07 30.1 11.3 2.3 1 1 0 1 1 1 1 Olfactory receptor SIM_C PF06621.12 EMC81866.1 - 5.7e-112 374.5 15.7 8.3e-112 374.0 15.7 1.2 1 0 0 1 1 1 1 Single-minded protein C-terminus PAS_3 PF08447.12 EMC81866.1 - 4.2e-26 91.1 2.4 6e-19 68.1 0.1 3.2 3 0 0 3 3 3 2 PAS fold PAS_11 PF14598.6 EMC81866.1 - 6e-20 71.5 0.9 4.4e-14 52.6 0.1 2.8 3 0 0 3 3 3 2 PAS domain PAS PF00989.25 EMC81866.1 - 2.9e-18 65.9 0.0 6.9e-12 45.4 0.0 2.7 2 0 0 2 2 2 2 PAS fold HLH PF00010.26 EMC81866.1 - 2.9e-06 27.1 0.9 5.4e-05 23.1 0.7 2.5 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.7 EMC81866.1 - 0.00017 21.8 0.0 0.017 15.3 0.0 2.6 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 EMC81866.1 - 0.00052 20.2 0.0 0.03 14.6 0.0 2.7 3 0 0 3 3 3 1 PAS fold SRCR PF00530.18 EMC81867.1 - 3e-54 181.7 14.1 4.1e-32 110.7 6.8 2.0 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 EMC81867.1 - 4.6e-10 39.9 3.1 5e-05 23.8 0.3 2.3 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 EMC81867.1 - 0.0012 19.3 1.2 0.34 11.4 0.1 2.5 2 0 0 2 2 2 2 Hepsin, SRCR domain PXA PF02194.15 EMC81868.1 - 7.6e-32 110.7 0.0 3.1e-31 108.8 0.0 2.1 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 EMC81868.1 - 1.1e-22 80.7 0.5 6.7e-22 78.2 0.2 2.5 2 0 0 2 2 2 1 Sorting nexin C terminal PX PF00787.24 EMC81868.1 - 6.3e-19 68.0 0.2 1.5e-18 66.8 0.2 1.6 1 0 0 1 1 1 1 PX domain TssC PF17541.2 EMC81868.1 - 0.054 12.3 0.1 0.079 11.8 0.1 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssC, VipB ADAM_spacer1 PF05986.14 EMC81869.1 - 1.9e-23 82.7 0.0 4.2e-23 81.6 0.0 1.6 1 1 0 1 1 1 1 ADAM-TS Spacer 1 ADAM_CR_2 PF17771.1 EMC81869.1 - 3e-20 72.5 14.5 2.3e-18 66.4 7.8 4.3 4 0 0 4 4 4 2 ADAM cysteine-rich domain Reprolysin PF01421.19 EMC81869.1 - 1.3e-18 67.7 0.0 1.3e-18 67.7 0.0 2.1 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.6 EMC81869.1 - 7.7e-13 49.0 0.0 1.2e-12 48.4 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EMC81869.1 - 6.2e-09 36.4 0.0 9.4e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like TSP_1 PF00090.19 EMC81869.1 - 1.6e-07 31.5 21.7 6e-07 29.6 3.7 5.4 5 1 0 5 5 5 2 Thrombospondin type 1 domain Reprolysin_2 PF13574.6 EMC81869.1 - 0.0011 18.9 0.0 0.0021 18.0 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EMC81869.1 - 0.16 11.6 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like ADAM_spacer1 PF05986.14 EMC81870.1 - 6.8e-23 80.9 0.0 1e-22 80.3 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 ADAM_CR_2 PF17771.1 EMC81870.1 - 1.2e-22 80.2 13.8 1.4e-20 73.6 7.7 5.0 5 0 0 5 5 5 2 ADAM cysteine-rich domain Reprolysin PF01421.19 EMC81870.1 - 7.4e-19 68.4 0.0 1.2e-18 67.8 0.0 1.3 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_3 PF13582.6 EMC81870.1 - 8.2e-12 45.7 0.0 1.6e-11 44.8 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EMC81870.1 - 1.3e-09 38.5 0.1 2.3e-09 37.7 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 TSP_1 PF00090.19 EMC81870.1 - 4.5e-08 33.2 16.7 4.7e-06 26.7 1.2 5.5 5 0 0 5 5 5 2 Thrombospondin type 1 domain Reprolysin_2 PF13574.6 EMC81870.1 - 9.4e-06 25.7 0.0 1.5e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EMC81870.1 - 0.00028 20.6 0.0 0.00046 19.9 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_Tenascin PF18720.1 EMC81870.1 - 0.19 11.8 9.5 2.3 8.3 0.7 3.6 3 0 0 3 3 3 0 Tenascin EGF domain BTB PF00651.31 EMC81871.1 - 2.1e-29 102.0 0.6 3.6e-29 101.2 0.6 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.26 EMC81871.1 - 4.7e-19 67.7 24.4 0.00014 22.1 0.4 4.8 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC81871.1 - 4.1e-15 55.2 18.1 0.0022 18.7 0.4 4.9 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC81871.1 - 5e-13 48.8 23.5 2.8e-06 27.5 0.3 5.0 5 0 0 5 5 5 4 Zinc-finger double domain zf-met PF12874.7 EMC81871.1 - 2.2e-10 40.5 19.4 0.013 15.8 0.3 5.6 5 0 0 5 5 5 4 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EMC81871.1 - 1.1e-08 34.9 24.1 0.0055 16.7 0.1 4.9 5 0 0 5 5 4 4 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EMC81871.1 - 1.3e-07 31.2 20.3 0.012 15.4 0.3 4.8 4 0 0 4 4 4 2 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 EMC81871.1 - 2.9e-06 27.4 9.5 0.025 14.9 0.0 4.6 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EMC81871.1 - 0.00014 22.1 13.0 0.3 11.4 2.4 4.1 1 1 3 4 4 4 2 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 EMC81871.1 - 0.0013 18.8 9.7 5.7 7.1 3.0 4.0 2 1 2 4 4 4 2 Zinc ribbon domain zf-C2HE PF16278.5 EMC81871.1 - 0.006 17.0 10.9 0.21 12.1 0.0 4.5 2 1 2 4 4 4 1 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_3rep PF18868.1 EMC81871.1 - 0.011 16.4 6.9 0.36 11.5 0.4 3.8 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_9 PF16293.5 EMC81871.1 - 0.023 14.5 3.3 0.16 11.8 0.1 3.2 3 0 0 3 3 2 0 C2H2 type zinc-finger (1 copy) Glyco_tran_10_N PF17039.5 EMC81871.1 - 0.037 14.5 0.2 0.15 12.5 0.2 2.1 1 0 0 1 1 1 0 Fucosyltransferase, N-terminal zf-H2C2_5 PF13909.6 EMC81871.1 - 0.097 12.5 0.1 0.097 12.5 0.1 3.0 3 0 0 3 3 2 0 C2H2-type zinc-finger domain Zn_Tnp_IS1595 PF12760.7 EMC81871.1 - 0.61 10.1 20.3 0.18 11.8 3.6 3.2 1 1 2 3 3 3 0 Transposase zinc-ribbon domain FYVE PF01363.21 EMC81871.1 - 0.8 9.9 14.5 4.1 7.6 4.5 4.2 1 1 1 2 2 2 0 FYVE zinc finger CpXC PF14353.6 EMC81871.1 - 1 9.4 9.2 43 4.2 6.4 3.6 1 1 2 3 3 3 0 CpXC protein zf-AN1 PF01428.16 EMC81871.1 - 2.1 8.6 12.3 6.1 7.1 0.1 4.6 4 0 0 4 4 4 0 AN1-like Zinc finger C1_1 PF00130.22 EMC81871.1 - 3 7.8 9.6 1 9.3 3.8 2.9 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf_UBZ PF18439.1 EMC81871.1 - 3.5 7.3 11.0 2.2 7.9 0.1 4.3 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger LIM PF00412.22 EMC81871.1 - 4.7 7.5 12.5 3.1 8.1 6.2 3.5 3 1 0 3 3 3 0 LIM domain Trypsin PF00089.26 EMC81872.1 - 5.2e-67 225.9 0.3 9.3e-67 225.1 0.3 1.4 1 0 0 1 1 1 1 Trypsin CUB PF00431.20 EMC81872.1 - 1e-35 122.4 0.2 3.3e-19 69.3 0.1 2.6 2 0 0 2 2 2 2 CUB domain Ldl_recept_a PF00057.18 EMC81872.1 - 6.3e-35 119.1 83.5 5.8e-10 39.2 8.9 4.9 5 0 0 5 5 5 4 Low-density lipoprotein receptor domain class A SEA PF01390.20 EMC81872.1 - 1.5e-12 47.5 0.1 7.7e-12 45.2 0.0 2.0 2 0 0 2 2 2 1 SEA domain DUF1986 PF09342.11 EMC81872.1 - 4.3e-06 27.1 0.0 1e-05 25.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) CUB_2 PF02408.20 EMC81872.1 - 0.00022 21.0 1.5 0.0026 17.5 0.3 2.5 2 0 0 2 2 2 1 CUB-like domain NFRKB_winged PF14465.6 EMC81873.1 - 9.7e-32 109.2 2.8 2.1e-31 108.2 1.4 2.4 2 0 0 2 2 2 1 NFRKB Winged Helix-like Apt1 PF10351.9 EMC81873.1 - 0.018 13.9 0.3 0.04 12.8 0.3 1.6 1 0 0 1 1 1 0 Golgi-body localisation protein domain ATP-synt_E PF05680.12 EMC81873.1 - 1.8 9.0 7.9 0.97 9.8 2.1 2.7 2 0 0 2 2 2 0 ATP synthase E chain Tristanin_u2 PF16638.5 EMC81874.1 - 5.5e-50 169.6 5.7 5.5e-50 169.6 5.7 4.1 3 1 0 3 3 1 1 Unstructured region on methyltransferase between zinc-fingers zf-C2H2 PF00096.26 EMC81874.1 - 5.7e-33 111.5 77.3 5.6e-05 23.4 2.5 11.0 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC81874.1 - 8.8e-27 91.5 80.2 0.0047 17.6 1.7 11.0 11 0 0 11 11 10 10 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC81874.1 - 3.4e-18 65.2 66.7 0.00048 20.4 0.4 12.1 11 1 0 11 11 11 7 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EMC81874.1 - 3.8e-15 55.7 56.8 0.0024 18.1 0.0 10.7 11 0 0 11 11 11 7 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EMC81874.1 - 3.1e-08 33.9 47.3 0.13 12.6 10.6 9.3 5 2 2 8 8 8 4 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 EMC81874.1 - 5e-07 29.6 49.3 0.0033 17.4 0.4 9.0 8 0 0 8 8 8 4 C2H2-type zinc finger zf-met PF12874.7 EMC81874.1 - 8.3e-06 26.0 2.6 0.0032 17.8 0.0 9.4 9 0 0 9 9 8 3 Zinc-finger of C2H2 type zf_PR_Knuckle PF18445.1 EMC81874.1 - 8.5e-06 25.5 2.0 8.5e-06 25.5 2.0 3.9 4 0 0 4 4 3 1 PR zinc knuckle motif zf-C2H2_3rep PF18868.1 EMC81874.1 - 3.5e-05 24.5 29.4 1.8 9.3 0.8 7.9 6 1 2 8 8 7 4 Zinc finger C2H2-type, 3 repeats zf-Di19 PF05605.12 EMC81874.1 - 0.0034 17.6 44.5 0.086 13.1 2.6 7.6 6 1 3 9 9 9 4 Drought induced 19 protein (Di19), zinc-binding zf_UBZ PF18439.1 EMC81874.1 - 0.01 15.4 40.3 1.1 8.9 0.1 8.9 9 0 0 9 9 9 0 Ubiquitin-Binding Zinc Finger zf-BED PF02892.15 EMC81874.1 - 0.015 15.3 3.0 0.015 15.3 3.0 7.5 6 2 2 8 8 8 0 BED zinc finger zf_C2H2_ZHX PF18387.1 EMC81874.1 - 0.48 10.1 0.0 0.48 10.1 0.0 8.0 8 1 1 9 9 9 0 Zinc-fingers and homeoboxes C2H2 finger domain Zn_Tnp_IS1595 PF12760.7 EMC81874.1 - 0.7 9.9 26.1 0.05 13.6 1.5 5.7 5 0 0 5 5 5 0 Transposase zinc-ribbon domain DUF629 PF04780.12 EMC81874.1 - 1.7 7.1 45.7 0.28 9.7 0.0 7.6 5 2 2 8 8 8 0 Protein of unknown function (DUF629) DNA_pol_phi PF04931.13 EMC81874.1 - 6.4 4.7 6.9 9.8 4.1 6.9 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF4428 PF14471.6 EMC81874.1 - 7.6 6.5 12.0 1.1 9.2 0.0 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4428) APP_E2 PF12925.7 EMC81875.1 - 1.8e-69 233.3 18.7 4.3e-69 232.0 18.7 1.7 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein APP_N PF02177.16 EMC81875.1 - 1e-42 144.6 1.0 1e-42 144.6 1.0 2.5 3 0 0 3 3 3 1 Amyloid A4 N-terminal heparin-binding APP_Cu_bd PF12924.7 EMC81875.1 - 4.3e-27 94.6 5.9 4.3e-27 94.6 5.9 3.5 3 0 0 3 3 3 1 Copper-binding of amyloid precursor, CuBD APP_amyloid PF10515.9 EMC81875.1 - 6.8e-26 90.5 0.2 4.1e-25 88.0 0.2 2.5 1 0 0 1 1 1 1 Beta-amyloid precursor protein C-terminus Kunitz_BPTI PF00014.23 EMC81875.1 - 7.8e-20 70.9 5.1 7.8e-20 70.9 5.1 2.2 3 0 0 3 3 3 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Insulin_TMD PF17870.1 EMC81875.1 - 0.22 11.6 0.4 0.43 10.7 0.4 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment FNIP_M PF14637.6 EMC81875.1 - 0.85 9.6 3.4 13 5.7 0.4 2.4 2 0 0 2 2 2 0 Folliculin-interacting protein middle domain Activator-TraM PF11657.8 EMC81875.1 - 1.5 8.6 6.1 3.5 7.5 6.1 1.5 1 0 0 1 1 1 0 Transcriptional activator TraM DUF716 PF04819.12 EMC81876.1 - 5.4e-28 97.4 2.0 5.4e-28 97.4 2.0 2.0 2 0 0 2 2 2 1 Family of unknown function (DUF716) DUF716 PF04819.12 EMC81877.1 - 8e-30 103.3 10.4 1.5e-29 102.4 10.4 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF716) TMIE PF16038.5 EMC81877.1 - 3.1 7.7 6.3 0.16 11.8 0.7 1.8 2 0 0 2 2 2 0 TMIE protein Homeodomain PF00046.29 EMC81878.1 - 3.6e-21 74.8 3.4 3.6e-21 74.8 3.4 1.8 2 0 0 2 2 2 1 Homeodomain MDFI PF15316.6 EMC81879.1 - 1.2e-44 152.4 54.4 1.4e-44 152.2 54.4 1.0 1 0 0 1 1 1 1 MyoD family inhibitor HLH PF00010.26 EMC81880.1 - 1.3e-15 57.1 0.7 2.1e-15 56.4 0.7 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF3371 PF11851.8 EMC81880.1 - 5.7e-10 40.4 0.3 2.7e-09 38.2 0.0 2.1 2 1 0 2 2 2 1 Domain of unknown function (DUF3371) GPHR_N PF12537.8 EMC81880.1 - 0.0046 17.0 1.4 1.1 9.4 0.0 2.3 2 0 0 2 2 2 2 The Golgi pH Regulator (GPHR) Family N-terminal THF_DHG_CYH PF00763.23 EMC81880.1 - 0.078 13.2 0.1 0.15 12.3 0.1 1.6 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain PGBA_C PF15437.6 EMC81880.1 - 9.3 6.7 9.7 14 6.1 3.2 2.3 2 0 0 2 2 2 0 Plasminogen-binding protein pgbA C-terminal Asp PF00026.23 EMC81881.1 - 9.7e-45 153.3 0.2 1.1e-44 153.2 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EMC81881.1 - 1.9e-10 41.3 1.9 7.8e-08 32.8 1.9 2.1 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EMC81881.1 - 0.00044 20.8 0.0 0.0014 19.2 0.0 1.7 1 1 0 1 1 1 1 Aspartyl protease DUF1614 PF07758.11 EMC81881.1 - 0.044 13.8 0.0 0.075 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1614) LIM PF00412.22 EMC81882.1 - 1e-20 73.7 27.6 2.1e-11 43.9 4.0 3.7 3 1 0 3 3 3 2 LIM domain PET PF06297.14 EMC81882.1 - 7.7e-05 22.9 0.0 0.00011 22.4 0.0 1.3 1 0 0 1 1 1 1 PET Domain UCH PF00443.29 EMC81883.1 - 1.1e-57 195.5 2.8 1.2e-57 195.3 0.1 2.0 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EMC81883.1 - 4.2e-21 75.1 6.8 4.2e-21 75.1 6.8 2.7 4 0 0 4 4 4 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 EMC81883.1 - 4.1e-16 59.5 0.4 4.1e-16 59.5 0.4 2.5 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 EMC81883.1 - 0.039 13.7 0.4 0.039 13.7 0.4 2.4 2 0 0 2 2 2 0 Variant UBP zinc finger Stc1 PF12898.7 EMC81883.1 - 0.21 12.2 0.1 0.21 12.2 0.1 2.9 3 0 0 3 3 3 0 Stc1 domain DUF3069 PF11269.8 EMC81883.1 - 0.21 11.8 2.2 0.64 10.3 2.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3069) APH PF01636.23 EMC81883.1 - 0.24 11.3 2.7 0.45 10.4 2.7 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Med20 PF08612.11 EMC81884.1 - 1.5e-35 122.6 0.0 1.8e-35 122.4 0.0 1.0 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex Bromo_TP PF07524.13 EMC81885.1 - 1.3e-30 105.2 0.7 3.3e-30 103.9 0.2 1.8 2 0 0 2 2 2 1 Bromodomain associated TAF8_C PF10406.9 EMC81885.1 - 1.2e-22 80.2 1.3 3.2e-22 78.8 1.3 1.8 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term TFIID-31kDa PF02291.15 EMC81885.1 - 2.7e-05 24.2 0.0 4.6e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP_like PF17027.5 EMC81885.1 - 0.00027 21.1 0.0 0.00053 20.1 0.0 1.5 1 0 0 1 1 1 1 Histone-fold protein DUF3090 PF11290.8 EMC81885.1 - 0.0054 16.6 0.4 0.018 14.8 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3090) CENP-S PF15630.6 EMC81885.1 - 0.019 15.3 0.0 0.05 14.0 0.0 1.8 1 1 0 1 1 1 0 CENP-S protein CBFD_NFYB_HMF PF00808.23 EMC81885.1 - 0.048 13.9 0.1 0.095 13.0 0.1 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.6 EMC81885.1 - 0.079 13.1 0.0 0.22 11.7 0.0 1.8 2 0 0 2 2 2 0 Centromere kinetochore component CENP-T histone fold BTG PF07742.12 EMC81886.1 - 1.1e-41 141.3 0.0 1.3e-41 141.1 0.0 1.1 1 0 0 1 1 1 1 BTG family LRR_8 PF13855.6 EMC81887.1 - 2.3e-32 110.5 26.7 6.2e-11 41.9 1.3 6.1 3 3 3 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 EMC81887.1 - 8e-24 83.3 28.7 1.6e-06 28.3 0.9 6.9 2 2 6 8 8 8 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC81887.1 - 1.1e-10 41.2 5.1 3.6e-05 23.3 0.2 3.9 1 1 3 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 EMC81887.1 - 3.5e-08 32.9 31.0 0.17 12.5 0.1 10.1 11 1 0 11 11 11 3 Leucine Rich Repeat LRR_5 PF13306.6 EMC81887.1 - 8.2e-08 32.3 2.5 6.9e-06 26.0 0.0 2.5 2 1 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 EMC81887.1 - 9.5e-08 31.5 19.3 0.34 11.1 0.0 8.6 10 0 0 10 10 10 3 Leucine Rich repeat LRRNT PF01462.18 EMC81887.1 - 1.2e-06 28.0 2.5 1.2e-06 28.0 2.5 3.1 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain FNIP PF05725.12 EMC81887.1 - 6.5e-06 26.2 1.1 0.12 12.6 0.0 4.6 2 2 1 3 3 3 2 FNIP Repeat Pentapeptide_4 PF13599.6 EMC81887.1 - 0.15 12.2 0.2 29 4.9 0.0 2.5 2 1 0 2 2 2 0 Pentapeptide repeats (9 copies) LRR_4 PF12799.7 EMC81888.1 - 3.6e-12 46.3 25.3 6e-07 29.7 4.8 3.2 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMC81888.1 - 8.9e-12 44.6 12.2 0.00024 20.8 9.4 4.0 1 1 2 3 3 3 3 Leucine rich repeat LRR_6 PF13516.6 EMC81888.1 - 1.1e-05 25.1 5.1 2.6 8.3 0.0 4.4 4 0 0 4 4 4 2 Leucine Rich repeat LRR_1 PF00560.33 EMC81888.1 - 0.0032 17.8 10.8 0.14 12.8 0.1 4.4 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_9 PF14580.6 EMC81888.1 - 0.044 13.3 1.0 0.11 12.0 1.0 2.0 1 1 0 1 1 1 0 Leucine-rich repeat zf-CCCH_3 PF15663.5 EMC81892.1 - 2.3e-37 127.5 1.1 4.2e-37 126.7 1.1 1.4 1 0 0 1 1 1 1 Zinc-finger containing family zf_CCCH_4 PF18345.1 EMC81892.1 - 0.042 13.9 1.8 0.042 13.9 1.8 3.7 4 0 0 4 4 4 0 Zinc finger domain DUF5571 PF17732.1 EMC81892.1 - 0.14 11.5 7.9 0.052 13.0 1.0 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5571) zf-CCCH_2 PF14608.6 EMC81892.1 - 2 9.0 12.3 0.75 10.4 4.1 2.9 2 1 1 3 3 3 0 RNA-binding, Nab2-type zinc finger Choline_kinase PF01633.20 EMC81893.1 - 7.8e-59 198.8 0.0 1.1e-58 198.3 0.0 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EMC81893.1 - 1.5e-13 51.3 0.1 2e-13 50.8 0.1 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EMC81893.1 - 0.0016 17.8 1.7 0.0046 16.3 1.7 1.7 1 1 0 1 1 1 1 Ecdysteroid kinase Tsi6 PF18660.1 EMC81893.1 - 0.11 12.5 0.3 2.9 8.0 0.1 2.8 2 1 1 3 3 3 0 Tsi6 Asp PF00026.23 EMC81894.1 - 4.3e-16 59.2 0.1 5e-16 59.0 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EMC81894.1 - 1.1e-07 32.2 0.1 1.4e-07 31.9 0.1 1.2 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.12 EMC81894.1 - 2e-05 24.3 0.3 4.6e-05 23.2 0.2 1.6 2 0 0 2 2 2 1 A1 Propeptide Got1 PF04178.12 EMC81895.1 - 1.7e-16 60.6 18.3 2.1e-16 60.4 18.3 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family PP1c_bdg PF10488.9 EMC81896.1 - 8.3e-118 393.0 6.1 9.5e-118 392.8 6.1 1.0 1 0 0 1 1 1 1 Phosphatase-1 catalytic subunit binding region HIGH_NTase1_ass PF16581.5 EMC81896.1 - 0.1 12.6 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region VEFS-Box PF09733.9 EMC81896.1 - 0.11 12.3 5.2 1.7 8.5 0.3 2.2 2 0 0 2 2 2 0 VEFS-Box of polycomb protein SDA1 PF05285.12 EMC81896.1 - 2.4 7.5 8.6 3.5 6.9 8.6 1.2 1 0 0 1 1 1 0 SDA1 PI3_PI4_kinase PF00454.27 EMC81897.1 - 7.2e-59 199.6 0.6 3.1e-58 197.5 0.6 1.9 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PX PF00787.24 EMC81897.1 - 2.3e-17 63.0 0.0 4.7e-17 62.0 0.0 1.6 1 0 0 1 1 1 1 PX domain C2 PF00168.30 EMC81897.1 - 2.8e-17 62.9 0.0 4.7e-17 62.2 0.0 1.4 1 0 0 1 1 1 1 C2 domain DUF4135 PF13575.6 EMC81897.1 - 0.00029 20.3 0.0 0.00045 19.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) zf-C3HC4_3 PF13920.6 EMC81898.1 - 7.1e-11 41.8 6.1 7.1e-11 41.8 6.1 2.9 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RanBP PF00641.18 EMC81898.1 - 9.5e-06 24.8 8.1 9.5e-06 24.8 8.1 3.0 3 0 0 3 3 3 1 Zn-finger in Ran binding protein and others zinc_ribbon_15 PF17032.5 EMC81898.1 - 0.033 14.9 5.2 0.033 14.9 5.2 2.6 2 1 0 2 2 2 0 zinc-ribbon family DZR PF12773.7 EMC81898.1 - 0.16 12.1 14.9 1.1 9.3 2.1 2.9 2 1 1 3 3 3 0 Double zinc ribbon Prok-RING_4 PF14447.6 EMC81898.1 - 4.8 7.1 15.3 0.071 13.0 4.4 3.0 2 2 0 2 2 2 0 Prokaryotic RING finger family 4 LRR_8 PF13855.6 EMC81899.1 - 1.7e-60 200.6 71.9 6.8e-15 54.6 7.4 6.6 2 1 6 8 8 8 7 Leucine rich repeat LRR_5 PF13306.6 EMC81899.1 - 1.2e-25 90.0 0.0 4.1e-09 36.5 0.0 2.8 1 1 3 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 EMC81899.1 - 1.5e-24 85.6 45.5 2.6e-05 24.5 2.6 8.1 2 1 5 9 9 9 9 Leucine Rich repeats (2 copies) I-set PF07679.16 EMC81899.1 - 4.8e-15 55.4 0.0 8.4e-15 54.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain LRR_9 PF14580.6 EMC81899.1 - 1.6e-14 53.8 17.2 0.00018 21.0 1.9 4.6 1 1 4 5 5 5 5 Leucine-rich repeat Ig_3 PF13927.6 EMC81899.1 - 1.8e-11 44.5 0.0 4.3e-11 43.3 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC81899.1 - 5e-07 30.0 0.0 1e-06 29.0 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC81899.1 - 2.7e-06 27.5 0.0 5.2e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.33 EMC81899.1 - 0.00013 22.1 34.8 0.17 12.6 0.1 10.6 12 0 0 12 12 10 2 Leucine Rich Repeat V-set PF07686.17 EMC81899.1 - 0.00014 22.0 0.0 0.0011 19.1 0.0 2.2 1 1 0 1 1 1 1 Immunoglobulin V-set domain LRRCT PF01463.24 EMC81899.1 - 0.032 14.8 0.2 0.22 12.2 0.2 2.6 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain fn3 PF00041.21 EMC81899.1 - 0.13 12.6 0.4 0.27 11.6 0.4 1.5 1 0 0 1 1 1 0 Fibronectin type III domain LRRNT PF01462.18 EMC81899.1 - 4.7 7.0 7.6 0.55 9.9 1.8 2.6 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain LRIF1 PF15741.5 EMC81900.1 - 1.6e-174 582.4 31.9 1.8e-174 582.3 31.9 1.0 1 0 0 1 1 1 1 Ligand-dependent nuclear receptor-interacting factor 1 FAD_binding_7 PF03441.14 EMC81901.1 - 1.7e-79 266.0 2.8 2.8e-79 265.3 2.8 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 EMC81901.1 - 1.7e-36 125.7 0.0 5e-36 124.2 0.0 1.7 2 0 0 2 2 2 1 DNA photolyase UQ_con PF00179.26 EMC81902.1 - 6.6e-36 123.0 0.0 8.6e-36 122.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EMC81902.1 - 0.0022 17.7 0.0 0.0035 17.0 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EMC81902.1 - 0.018 15.4 0.7 0.024 14.9 0.6 1.5 1 1 0 1 1 1 0 RWD domain UEV PF05743.13 EMC81902.1 - 0.031 14.1 0.2 0.062 13.2 0.2 1.5 1 1 0 1 1 1 0 UEV domain Tetraspanin PF00335.20 EMC81903.1 - 7.5e-15 55.3 6.3 8.2e-15 55.1 6.3 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF3681 PF12442.8 EMC81903.1 - 0.024 15.1 3.2 0.031 14.7 3.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3681) Phage_holin_3_6 PF07332.11 EMC81903.1 - 2.6 8.1 10.5 3.2 7.8 10.5 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III HlyIII PF03006.20 EMC81904.1 - 3.4e-73 246.1 19.6 4.1e-73 245.8 19.6 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF4405 PF14358.6 EMC81904.1 - 0.013 16.0 3.4 0.013 16.0 3.4 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF4405) DUF962 PF06127.11 EMC81904.1 - 2.8 8.1 9.6 0.063 13.4 1.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF962) Tim17 PF02466.19 EMC81905.1 - 2e-31 108.6 4.7 2.5e-31 108.3 4.7 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family PNISR PF15996.5 EMC81906.1 - 1.5e-05 25.4 21.7 1.5e-05 25.4 21.7 1.8 3 0 0 3 3 3 1 Arginine/serine-rich protein PNISR Tropomodulin PF03250.14 EMC81906.1 - 0.0026 17.8 29.4 0.033 14.2 29.4 2.3 1 1 0 1 1 1 1 Tropomodulin LRR_6 PF13516.6 EMC81906.1 - 0.011 15.8 3.6 0.023 14.7 0.2 3.0 3 0 0 3 3 3 0 Leucine Rich repeat DUF966 PF06136.13 EMC81906.1 - 0.083 12.6 20.6 0.1 12.3 20.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Borrelia_P83 PF05262.11 EMC81906.1 - 0.24 9.8 30.3 0.32 9.5 30.3 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Mitofilin PF09731.9 EMC81906.1 - 0.3 9.9 32.9 0.39 9.5 32.9 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Macoilin PF09726.9 EMC81906.1 - 0.39 9.2 21.2 0.44 9.1 21.2 1.1 1 0 0 1 1 1 0 Macoilin family Ndc1_Nup PF09531.10 EMC81906.1 - 0.73 8.5 10.2 0.85 8.2 10.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF5427 PF10310.9 EMC81906.1 - 5.8 5.8 31.0 7.9 5.3 31.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Caldesmon PF02029.15 EMC81906.1 - 6 5.5 44.2 0.063 12.0 35.7 1.8 2 0 0 2 2 2 0 Caldesmon Shisa PF13908.6 EMC81907.1 - 1.6e-13 51.3 27.3 9.1e-12 45.6 27.4 2.3 1 1 0 1 1 1 1 Wnt and FGF inhibitory regulator 7tm_1 PF00001.21 EMC81908.1 - 4.3e-49 167.2 9.0 5.5e-49 166.9 9.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC81908.1 - 0.01 15.5 2.6 0.01 15.5 2.6 2.8 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC81908.1 - 0.019 14.7 0.5 0.019 14.7 0.5 2.0 2 0 0 2 2 2 0 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 EMC81908.1 - 0.034 13.5 8.2 0.52 9.7 8.2 2.2 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx DUF1151 PF06625.11 EMC81909.1 - 5e-14 52.2 0.8 1.6e-13 50.6 0.7 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF1151) Cadherin PF00028.17 EMC81910.1 - 5e-131 427.5 10.2 7.1e-23 80.9 0.0 6.1 6 0 0 6 6 6 6 Cadherin domain Cadherin_3 PF16184.5 EMC81910.1 - 5.4e-16 58.6 14.8 0.0018 18.3 0.3 7.0 7 0 0 7 7 7 6 Cadherin-like Cadherin_4 PF17803.1 EMC81910.1 - 1.7e-09 38.2 32.9 0.23 12.1 0.4 6.4 6 0 0 6 6 6 5 Bacterial cadherin-like domain Cadherin_pro PF08758.11 EMC81910.1 - 9.9e-06 25.6 0.0 1.1 9.5 0.0 3.9 3 1 0 3 3 3 2 Cadherin prodomain like Cadherin_2 PF08266.12 EMC81910.1 - 1.5e-05 24.7 0.0 5.1 7.0 0.0 5.2 5 0 0 5 5 5 2 Cadherin-like RET_CLD1 PF17756.1 EMC81910.1 - 0.0003 21.1 0.0 28 5.0 0.0 5.0 5 0 0 5 5 5 1 RET Cadherin like domain 1 Pro_isomerase PF00160.21 EMC81911.1 - 2.2e-50 171.0 0.0 2.5e-50 170.9 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD G-alpha PF00503.20 EMC81912.1 - 3.5e-116 388.2 2.4 4e-116 388.0 2.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EMC81912.1 - 3.1e-14 52.8 0.4 6.4e-13 48.5 0.1 2.8 2 1 1 3 3 3 1 ADP-ribosylation factor family G-alpha PF00503.20 EMC81913.1 - 1.1e-122 409.6 0.8 1.3e-122 409.3 0.8 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EMC81913.1 - 2.2e-16 59.8 1.8 4.7e-11 42.5 0.3 2.8 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EMC81913.1 - 0.00034 20.0 0.2 0.29 10.4 0.0 2.5 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EMC81913.1 - 0.0018 18.5 0.1 2.1 8.6 0.0 2.7 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase DAP3 PF10236.9 EMC81913.1 - 0.0077 15.4 0.6 0.013 14.7 0.6 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 TniB PF05621.11 EMC81913.1 - 0.071 12.5 0.1 0.13 11.6 0.1 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_29 PF13555.6 EMC81913.1 - 0.11 12.2 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 EMC81913.1 - 0.15 12.4 0.0 0.22 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain A_deaminase PF00962.22 EMC81914.1 - 3.5e-131 437.4 2.0 8.8e-131 436.1 2.0 1.6 1 1 0 1 1 1 1 Adenosine/AMP deaminase Amidohydro_1 PF01979.20 EMC81914.1 - 0.08 12.2 0.1 3.6 6.8 0.0 2.2 2 0 0 2 2 2 0 Amidohydrolase family PTB PF08416.13 EMC81915.1 - 3.2e-14 53.2 0.1 5.2e-14 52.5 0.1 1.3 1 0 0 1 1 1 1 Phosphotyrosine-binding domain CSF-1 PF05337.11 EMC81916.1 - 7.3e-19 68.3 3.9 1.1e-18 67.8 3.9 1.2 1 0 0 1 1 1 1 Macrophage colony stimulating factor-1 (CSF-1) AdoHcyase PF05221.17 EMC81917.1 - 2.3e-113 378.3 3.5 1.9e-64 217.7 1.5 3.0 2 1 1 3 3 3 3 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 EMC81917.1 - 7.9e-82 273.1 2.3 1.2e-81 272.5 2.3 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EMC81917.1 - 4.7e-09 35.8 0.0 1e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EMC81917.1 - 5.4e-05 22.8 0.1 0.00012 21.7 0.1 1.6 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain THF_DHG_CYH_C PF02882.19 EMC81917.1 - 0.0002 20.7 1.1 0.00096 18.5 1.1 1.8 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_7 PF13241.6 EMC81917.1 - 0.0011 19.4 1.3 0.005 17.3 0.9 2.3 2 1 1 3 3 3 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 EMC81917.1 - 0.0012 18.9 0.2 0.0036 17.4 0.2 1.7 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.21 EMC81917.1 - 0.0033 16.7 1.6 0.011 15.1 1.6 1.8 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 EMC81917.1 - 0.0048 17.1 0.3 0.018 15.3 0.3 2.0 1 1 0 1 1 1 1 TrkA-N domain NAD_binding_2 PF03446.15 EMC81917.1 - 0.11 12.7 0.1 0.24 11.6 0.1 1.6 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ELFV_dehydrog PF00208.21 EMC81917.1 - 0.2 11.3 1.9 4.4 6.9 0.2 2.3 1 1 1 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase SR-25 PF10500.9 EMC81917.1 - 0.51 9.9 6.3 0.78 9.3 6.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Homeodomain PF00046.29 EMC81918.1 - 6.6e-25 86.7 6.4 8.1e-25 86.4 6.4 1.1 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC81918.1 - 0.00011 22.0 0.2 0.0002 21.2 0.2 1.4 1 0 0 1 1 1 1 Homeobox KN domain Staygreen PF12638.7 EMC81918.1 - 0.022 14.6 0.0 0.022 14.6 0.0 1.1 1 0 0 1 1 1 0 Staygreen protein Chorion_S16 PF05836.12 EMC81918.1 - 0.14 12.4 0.0 0.81 9.9 0.0 1.9 2 0 0 2 2 2 0 Chorion protein S16 SNF PF00209.18 EMC81919.1 - 6.3e-221 734.6 32.8 7.8e-221 734.3 32.8 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Tmemb_18A PF09771.9 EMC81919.1 - 0.12 12.8 1.9 0.6 10.5 0.1 2.8 3 0 0 3 3 3 0 Transmembrane protein 188 Ion_trans PF00520.31 EMC81920.1 - 8.1e-43 146.4 15.9 9.8e-43 146.1 15.9 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 EMC81920.1 - 8.5e-11 41.7 3.9 8.5e-11 41.7 3.9 2.5 2 0 0 2 2 2 1 Ion channel PKD_channel PF08016.12 EMC81920.1 - 6.9 5.2 8.5 0.88 8.2 2.3 2.0 1 1 1 2 2 2 0 Polycystin cation channel SPOC PF07744.13 EMC81921.1 - 3.1e-28 98.6 0.0 4.6e-28 98.0 0.0 1.3 1 0 0 1 1 1 1 SPOC domain RRM_1 PF00076.22 EMC81921.1 - 8.2e-20 70.4 0.0 1.5e-12 47.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EMC81921.1 - 7.2e-07 29.1 0.0 0.00063 19.7 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EMC81921.1 - 0.00051 20.1 0.0 0.0052 16.8 0.0 2.2 1 1 1 2 2 2 1 RNA binding motif RRM_7 PF16367.5 EMC81921.1 - 0.034 14.2 0.0 3.5 7.8 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif K_channel_TID PF07941.11 EMC81921.1 - 3.5 8.1 11.9 0.13 12.7 2.7 2.8 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain MFS_1 PF07690.16 EMC81922.1 - 4.3e-25 88.4 27.1 1.1e-13 50.9 0.8 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily LAMTOR5 PF16672.5 EMC81923.1 - 1.6e-19 69.6 0.3 2.9e-19 68.8 0.1 1.5 2 0 0 2 2 2 1 Ragulator complex protein LAMTOR5 Prokineticin PF06607.11 EMC81924.1 - 5.7e-14 52.2 5.0 1.7e-11 44.3 2.2 2.0 1 1 1 2 2 2 2 Prokineticin Ion_trans PF00520.31 EMC81925.1 - 5.8e-50 169.8 13.4 7.8e-50 169.4 13.4 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 EMC81925.1 - 1.6e-27 95.6 0.0 3.9e-27 94.5 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 EMC81925.1 - 3.3e-13 49.4 5.8 3.3e-13 49.4 5.8 2.8 3 0 0 3 3 3 1 Ion channel PKD_channel PF08016.12 EMC81925.1 - 0.00085 18.1 0.6 0.00085 18.1 0.6 2.3 1 1 2 3 3 3 1 Polycystin cation channel DUF423 PF04241.15 EMC81925.1 - 1.2 9.4 3.8 1 9.6 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF423) DUF202 PF02656.15 EMC81925.1 - 1.4 9.4 5.0 1e+02 3.4 4.2 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF202) Sigma_reg_N PF13800.6 EMC81925.1 - 8.2 6.8 7.3 23 5.3 0.1 3.6 4 0 0 4 4 4 0 Sigma factor regulator N-terminal Ion_trans PF00520.31 EMC81926.1 - 6.6e-52 176.2 8.2 9e-52 175.7 8.2 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 EMC81926.1 - 1.6e-28 98.9 0.0 2.7e-28 98.1 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 EMC81926.1 - 1.2e-14 54.0 4.7 1.2e-14 54.0 4.7 2.6 3 0 0 3 3 3 1 Ion channel PKD_channel PF08016.12 EMC81926.1 - 0.0098 14.6 0.9 0.0098 14.6 0.9 1.7 2 0 0 2 2 2 1 Polycystin cation channel Sigma_reg_N PF13800.6 EMC81926.1 - 2 8.7 4.0 8.2 6.8 0.0 3.2 4 0 0 4 4 4 0 Sigma factor regulator N-terminal Ion_trans PF00520.31 EMC81927.1 - 2.8e-51 174.1 6.3 3.4e-51 173.8 6.3 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 EMC81927.1 - 8.4e-14 51.3 5.8 8.4e-14 51.3 5.8 2.5 3 0 0 3 3 3 1 Ion channel PKD_channel PF08016.12 EMC81927.1 - 0.00093 18.0 1.0 0.0012 17.6 0.3 1.5 1 1 0 1 1 1 1 Polycystin cation channel Sigma_reg_N PF13800.6 EMC81927.1 - 0.18 12.1 1.5 21 5.5 0.1 3.6 3 0 0 3 3 3 0 Sigma factor regulator N-terminal DUF423 PF04241.15 EMC81927.1 - 5.9 7.2 5.4 1.3 9.3 0.2 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF423) Patatin PF01734.22 EMC81928.1 - 1e-08 35.6 1.2 1.2e-06 28.9 1.2 2.2 1 1 0 1 1 1 1 Patatin-like phospholipase Ets PF00178.22 EMC81930.1 - 2.7e-28 98.2 1.4 2.7e-28 98.2 1.4 1.7 2 0 0 2 2 2 1 Ets-domain SAM_PNT PF02198.16 EMC81930.1 - 2.3e-25 88.3 0.0 6.5e-25 86.9 0.0 1.7 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain BTB_3 PF16017.5 EMC81931.1 - 6.6e-49 164.4 0.0 1.1e-48 163.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB_2 PF02214.22 EMC81931.1 - 2.2e-05 24.7 0.0 5.3e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Pkinase PF00069.25 EMC81932.1 - 4e-59 200.1 0.1 4e-59 200.1 0.1 2.1 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81932.1 - 2.8e-29 102.2 2.5 1.1e-20 74.1 0.2 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.24 EMC81932.1 - 1.3e-07 32.2 0.8 3.7e-07 30.7 0.5 2.0 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.6 EMC81932.1 - 5.7e-05 22.6 0.4 0.0015 17.9 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EMC81932.1 - 7e-05 21.9 0.3 0.00014 20.9 0.1 1.4 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EMC81932.1 - 0.0006 19.8 0.1 0.036 14.0 0.2 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EMC81932.1 - 0.00096 18.6 0.0 0.002 17.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EMC81932.1 - 0.09 11.8 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 MEKHLA PF08670.11 EMC81932.1 - 0.18 11.7 1.4 1.5 8.7 0.8 2.2 2 0 0 2 2 2 0 MEKHLA domain RIO1 PF01163.22 EMC81932.1 - 0.28 10.8 0.0 0.28 10.8 0.0 2.0 2 0 0 2 2 2 0 RIO1 family RRM_1 PF00076.22 EMC81933.1 - 2.7e-18 65.6 0.0 3.9e-18 65.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMC81933.1 - 0.0015 18.1 0.0 0.0019 17.8 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMC81933.1 - 0.084 12.7 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 Occluded RNA-recognition motif CDI PF02234.19 EMC81934.1 - 5.7e-21 74.4 3.4 7.5e-21 74.1 3.4 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor Ras PF00071.22 EMC81935.1 - 3.7e-49 166.4 0.0 4.3e-49 166.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC81935.1 - 4.6e-27 94.6 0.0 6.3e-27 94.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC81935.1 - 3.3e-15 56.0 0.0 4.3e-15 55.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EMC81935.1 - 3.2e-06 26.7 0.0 4.5e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EMC81935.1 - 1.6e-05 25.0 0.0 2.2e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC81935.1 - 1.9e-05 24.3 0.0 0.0011 18.5 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EMC81935.1 - 2.2e-05 23.9 0.0 2.5e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region CENP-M PF11111.8 EMC81935.1 - 0.076 12.2 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Centromere protein M (CENP-M) RsgA_GTPase PF03193.16 EMC81935.1 - 0.089 12.7 0.0 6.4 6.7 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase CAP PF00188.26 EMC81937.1 - 4.3e-16 59.9 1.4 8e-16 59.0 1.4 1.4 1 1 0 1 1 1 1 Cysteine-rich secretory protein family Mito_carr PF00153.27 EMC81938.1 - 7.5e-14 51.4 0.3 1e-08 35.0 0.0 2.9 3 1 0 3 3 3 2 Mitochondrial carrier protein Pkinase PF00069.25 EMC81939.1 - 2e-49 168.4 0.0 2.9e-49 167.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81939.1 - 4.6e-13 49.0 0.0 7.5e-13 48.3 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC81939.1 - 5e-08 32.6 0.0 5.8e-08 32.4 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC81939.1 - 2.1e-05 24.0 0.0 3e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMC81939.1 - 0.038 12.8 0.0 0.047 12.5 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EMC81939.1 - 0.051 13.5 0.1 0.092 12.7 0.1 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 EMC81939.1 - 0.055 13.0 0.0 0.075 12.6 0.0 1.1 1 0 0 1 1 1 0 Choline/ethanolamine kinase Seadorna_VP7 PF07387.11 EMC81939.1 - 0.15 11.1 0.0 0.24 10.4 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 RabGAP-TBC PF00566.18 EMC81940.1 - 9.4e-53 179.0 2.9 1.3e-52 178.6 2.9 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain MIF4G PF02854.19 EMC81940.1 - 0.091 12.4 0.0 2.1 7.9 0.0 2.4 1 1 2 3 3 3 0 MIF4G domain DUF4864 PF16156.5 EMC81940.1 - 0.092 13.4 0.0 0.23 12.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4864) NGF PF00243.18 EMC81941.1 - 6.4e-44 148.8 0.6 8.2e-44 148.4 0.6 1.1 1 0 0 1 1 1 1 Nerve growth factor family Tetraspanin PF00335.20 EMC81942.1 - 1.6e-33 116.4 9.5 1.9e-33 116.1 9.5 1.1 1 0 0 1 1 1 1 Tetraspanin family CD20 PF04103.15 EMC81942.1 - 1.3 9.1 10.2 4.2 7.4 10.3 2.0 1 1 0 1 1 1 0 CD20-like family Cys_knot PF00007.22 EMC81943.1 - 2.8e-31 107.9 15.5 3.4e-31 107.6 15.5 1.1 1 0 0 1 1 1 1 Cystine-knot domain zf-C4 PF00105.18 EMC81944.1 - 5.9e-29 100.3 14.4 5.9e-29 100.3 14.4 2.0 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 EMC81944.1 - 4.5e-12 46.0 0.0 1e-11 44.8 0.0 1.5 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor SIKE PF05769.11 EMC81945.1 - 1.4e-35 122.8 6.3 1.6e-35 122.7 6.3 1.0 1 0 0 1 1 1 1 SIKE family IL7 PF01415.16 EMC81945.1 - 0.016 15.3 0.4 0.042 13.9 0.2 1.7 1 1 1 2 2 2 0 Interleukin 7/9 family YabA PF06156.13 EMC81945.1 - 0.28 11.8 4.2 0.13 13.0 1.4 1.7 1 1 1 2 2 2 0 Initiation control protein YabA Ras PF00071.22 EMC81946.1 - 6.5e-43 146.1 0.1 7.4e-43 145.9 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC81946.1 - 2e-11 44.1 0.0 4.3e-11 43.1 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EMC81946.1 - 2e-06 27.5 0.0 3.8e-06 26.6 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 EMC81946.1 - 0.00015 21.3 0.0 0.0002 20.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EMC81946.1 - 0.0063 16.4 0.0 0.01 15.8 0.0 1.4 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 EMC81946.1 - 0.0073 15.9 0.0 0.015 14.8 0.0 1.4 1 1 0 1 1 1 1 Ferrous iron transport protein B TPP_enzyme_M PF00205.22 EMC81946.1 - 0.18 11.5 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain A_deaminase PF00962.22 EMC81947.1 - 9.2e-133 442.6 0.1 2.3e-132 441.3 0.1 1.6 1 1 0 1 1 1 1 Adenosine/AMP deaminase DENN PF02141.21 EMC81948.1 - 7.2e-61 205.4 1.4 1.3e-60 204.6 1.4 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 EMC81948.1 - 8.8e-16 58.4 1.0 2.1e-15 57.2 1.0 1.7 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 EMC81948.1 - 6.4e-12 45.3 2.2 1.7e-11 43.9 2.2 1.8 1 0 0 1 1 1 1 dDENN domain Bromodomain PF00439.25 EMC81949.1 - 3.4e-23 81.5 0.3 9.3e-23 80.1 0.3 1.8 1 0 0 1 1 1 1 Bromodomain zf-B_box PF00643.24 EMC81949.1 - 3.1e-12 46.4 18.6 1.6e-09 37.7 6.7 4.6 5 0 0 5 5 5 2 B-box zinc finger PHD PF00628.29 EMC81949.1 - 3.9e-08 33.1 9.5 3.9e-08 33.1 9.5 4.1 4 0 0 4 4 4 1 PHD-finger YgbB PF02542.16 EMC81949.1 - 0.25 11.6 3.2 0.27 11.5 0.0 2.2 2 0 0 2 2 2 0 YgbB family C2 PF00168.30 EMC81950.1 - 2.5e-54 181.9 0.0 6.1e-26 90.7 0.0 3.1 3 0 0 3 3 3 2 C2 domain CEP76-C2 PF15627.6 EMC81950.1 - 0.0003 20.4 0.0 0.052 13.1 0.1 2.8 3 0 0 3 3 3 2 CEP76 C2 domain PI3K_C2 PF00792.24 EMC81950.1 - 0.00036 20.5 0.1 0.12 12.3 0.0 3.0 4 0 0 4 4 4 2 Phosphoinositide 3-kinase C2 DOCK-C2 PF14429.6 EMC81950.1 - 0.039 13.8 0.0 1.7 8.4 0.0 2.2 2 0 0 2 2 2 0 C2 domain in Dock180 and Zizimin proteins OLF PF02191.16 EMC81951.1 - 1.3e-76 257.4 0.0 1.7e-76 257.1 0.0 1.1 1 0 0 1 1 1 1 Olfactomedin-like domain Glyco_hydro_100 PF12899.7 EMC81951.1 - 0.06 12.0 0.1 0.12 11.0 0.2 1.5 2 0 0 2 2 2 0 Alkaline and neutral invertase Golgin_A5 PF09787.9 EMC81951.1 - 0.084 12.3 5.2 0.14 11.6 5.2 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 bZIP_2 PF07716.15 EMC81951.1 - 0.16 12.1 8.8 1.3 9.2 2.9 2.5 2 0 0 2 2 2 0 Basic region leucine zipper Exonuc_VII_L PF02601.15 EMC81951.1 - 0.68 9.4 3.6 0.96 8.9 3.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Uso1_p115_C PF04871.13 EMC81951.1 - 3.4 8.0 6.9 15 5.9 6.9 1.9 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region XhlA PF10779.9 EMC81951.1 - 9.6 6.5 6.0 35 4.7 0.6 3.1 2 1 1 3 3 3 0 Haemolysin XhlA Pkinase PF00069.25 EMC81953.1 - 8.9e-51 172.8 0.0 1.6e-50 171.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81953.1 - 3.4e-24 85.5 0.0 5.4e-24 84.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMC81953.1 - 1.1e-05 24.9 0.0 3.3e-05 23.3 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMC81953.1 - 0.0072 15.2 0.0 0.015 14.1 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMC81953.1 - 0.015 15.3 0.0 0.028 14.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EMC81953.1 - 0.024 13.6 0.1 0.037 13.0 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DRMBL PF07522.14 EMC81954.1 - 6.6e-10 39.2 0.1 1.5e-09 38.0 0.1 1.7 1 1 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 EMC81954.1 - 2.8e-07 30.2 0.3 5.9e-07 29.2 0.3 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain RMMBL PF07521.12 EMC81954.1 - 0.066 13.2 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 EMC81954.1 - 4.9 7.1 7.7 7.1 6.6 3.8 2.8 2 1 0 2 2 2 0 Metallo-beta-lactamase superfamily Y_phosphatase PF00102.27 EMC81955.1 - 4.9e-81 271.8 0.2 5.9e-81 271.5 0.2 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EMC81955.1 - 5.3e-05 23.3 0.0 0.0001 22.4 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 EMC81955.1 - 0.0018 18.1 0.1 0.0038 17.0 0.1 1.6 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Phtf-FEM1B_bdg PF12129.8 EMC81957.1 - 1.5e-57 193.8 3.5 4.9e-57 192.1 3.5 1.9 1 0 0 1 1 1 1 Male germ-cell putative homeodomain transcription factor MFS_1 PF07690.16 EMC81960.1 - 1.2e-24 86.9 21.2 3.4e-19 69.0 21.7 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily TMEMspv1-c74-12 PF11044.8 EMC81960.1 - 0.063 13.3 0.2 0.063 13.3 0.2 2.4 3 0 0 3 3 3 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein DUF973 PF06157.11 EMC81960.1 - 0.095 11.7 0.6 1.5 7.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF973) ZapC PF07126.12 EMC81960.1 - 0.12 11.9 0.0 0.27 10.8 0.0 1.5 1 0 0 1 1 1 0 Cell-division protein ZapC DUF2140 PF09911.9 EMC81960.1 - 0.14 11.7 0.0 3.3 7.2 0.0 2.5 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) OAD_gamma PF04277.13 EMC81960.1 - 7.2 7.3 6.0 2e+02 2.7 0.0 3.2 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Ycf70 PF17382.2 EMC81960.1 - 8.8 6.8 6.4 4.6 7.7 0.0 2.8 3 0 0 3 3 3 0 Uncharacterized Ycf70-like TAFA PF12020.8 EMC81961.1 - 9.5e-49 163.8 11.2 1.2e-48 163.5 11.2 1.1 1 0 0 1 1 1 1 TAFA family PP2C PF00481.21 EMC81962.1 - 3.1e-26 92.6 0.0 2.8e-13 50.1 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 EMC81962.1 - 1.8e-05 24.7 0.0 0.0084 16.0 0.0 2.2 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) DUF424 PF04242.13 EMC81962.1 - 0.19 12.0 0.0 14 6.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF424) Ras PF00071.22 EMC81963.1 - 3.3e-58 195.9 0.0 3.8e-58 195.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC81963.1 - 2.6e-23 82.5 0.0 3.6e-23 82.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC81963.1 - 2.3e-10 40.2 0.0 3.8e-10 39.5 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC81963.1 - 0.00016 21.3 0.0 0.00031 20.3 0.0 1.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EMC81963.1 - 0.044 13.2 0.0 0.072 12.5 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EMC81963.1 - 0.046 13.1 0.0 0.064 12.6 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_12 PF13087.6 EMC81964.1 - 8.3e-49 165.9 0.0 1.2e-48 165.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EMC81964.1 - 1.3e-27 97.3 0.0 5.1e-13 49.4 0.0 2.2 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 EMC81964.1 - 9.3e-12 45.1 0.0 2.4e-11 43.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EMC81964.1 - 1.4e-08 35.2 0.0 2.5e-07 31.1 0.0 2.7 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 EMC81964.1 - 1.6e-05 25.0 0.0 3.3e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EMC81964.1 - 0.015 15.5 0.0 0.07 13.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain PIF1 PF05970.14 EMC81964.1 - 0.016 14.4 0.0 4.5 6.3 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase AAA PF00004.29 EMC81964.1 - 0.019 15.4 0.0 0.18 12.3 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) UvrD_C_2 PF13538.6 EMC81964.1 - 0.034 14.0 0.1 0.13 12.1 0.1 2.0 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 EMC81964.1 - 0.045 13.3 0.0 0.086 12.3 0.0 1.5 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_16 PF13191.6 EMC81964.1 - 0.099 13.0 0.0 0.27 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 EMC81964.1 - 0.13 11.8 0.0 0.32 10.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF126 PF01989.16 EMC81964.1 - 0.18 11.6 0.0 0.35 10.7 0.0 1.4 1 0 0 1 1 1 0 Aconitase X swivel domain F-actin_cap_A PF01267.17 EMC81966.1 - 7.2e-106 353.5 0.5 8.1e-106 353.3 0.5 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit CCP_MauG PF03150.14 EMC81966.1 - 0.0074 16.9 0.1 0.08 13.6 0.1 2.3 1 1 0 1 1 1 1 Di-haem cytochrome c peroxidase DUF5011 PF16403.5 EMC81966.1 - 0.29 11.3 1.6 0.7 10.1 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5011) ST7 PF04184.12 EMC81967.1 - 9.4e-287 951.7 1.6 1e-286 951.6 1.6 1.0 1 0 0 1 1 1 1 ST7 protein TPR_6 PF13174.6 EMC81967.1 - 0.0019 18.7 0.3 0.0091 16.6 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EMC81967.1 - 0.03 14.4 4.5 2 8.7 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat Clathrin PF00637.20 EMC81967.1 - 0.035 14.0 0.2 0.076 12.9 0.2 1.5 1 0 0 1 1 1 0 Region in Clathrin and VPS TPR_1 PF00515.28 EMC81967.1 - 0.036 13.9 4.4 11 6.1 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EMC81967.1 - 0.17 12.2 1.8 22 5.6 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EMC81967.1 - 0.21 12.1 0.1 0.21 12.1 0.1 3.7 2 1 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EMC81967.1 - 2.9 8.9 11.9 18 6.5 0.7 4.9 5 1 1 6 6 6 0 Tetratricopeptide repeat wnt PF00110.19 EMC81969.1 - 3.4e-91 306.1 5.8 3.8e-91 305.9 5.8 1.0 1 0 0 1 1 1 1 wnt family SUI1 PF01253.22 EMC81970.1 - 1.7e-20 73.3 0.3 3.3e-20 72.4 0.3 1.5 1 0 0 1 1 1 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 EMC81970.1 - 2.9e-20 72.7 0.2 1.3e-19 70.6 0.1 2.3 2 0 0 2 2 2 1 Pre-PUA-like domain PUA PF01472.20 EMC81970.1 - 0.00014 21.8 0.3 0.00042 20.2 0.2 1.9 2 0 0 2 2 2 1 PUA domain SWIB PF02201.18 EMC81970.1 - 0.0012 18.7 0.1 0.0039 17.0 0.1 1.9 1 0 0 1 1 1 1 SWIB/MDM2 domain Pkinase PF00069.25 EMC81971.1 - 1.6e-58 198.1 0.0 2.2e-58 197.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81971.1 - 2.7e-21 76.0 0.1 6.3e-21 74.8 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EMC81971.1 - 1.9e-05 24.7 0.0 0.0028 17.6 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 EMC81971.1 - 0.0026 17.4 2.3 0.003 17.2 0.4 1.9 2 0 0 2 2 2 1 RIO1 family Choline_kinase PF01633.20 EMC81971.1 - 0.0034 17.0 1.6 0.0072 15.9 1.6 1.6 1 0 0 1 1 1 1 Choline/ethanolamine kinase YrbL-PhoP_reg PF10707.9 EMC81971.1 - 0.0038 16.8 1.2 0.16 11.5 0.0 2.4 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL Kdo PF06293.14 EMC81971.1 - 0.015 14.6 0.2 0.032 13.6 0.1 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EMC81972.1 - 2.8e-63 213.8 0.0 3.8e-63 213.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81972.1 - 9.2e-27 93.9 0.0 1.3e-26 93.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMC81972.1 - 1.6e-06 27.7 0.1 2.7e-06 26.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EMC81972.1 - 1.1e-05 24.9 0.0 1.6e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMC81972.1 - 0.0052 15.6 0.0 0.0091 14.8 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Choline_kinase PF01633.20 EMC81972.1 - 0.043 13.4 0.2 0.1 12.2 0.0 1.6 2 0 0 2 2 2 0 Choline/ethanolamine kinase IL10 PF00726.17 EMC81973.1 - 1.3e-50 171.2 1.7 1.6e-50 171.0 1.7 1.0 1 0 0 1 1 1 1 Interleukin 10 IL22 PF14565.6 EMC81973.1 - 3.5e-08 33.8 0.8 4.6e-08 33.4 0.8 1.1 1 0 0 1 1 1 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor TFIID-18kDa PF02269.16 EMC81973.1 - 0.018 15.1 0.2 0.039 14.0 0.0 1.6 2 0 0 2 2 2 0 Transcription initiation factor IID, 18kD subunit DUF1296 PF06972.11 EMC81973.1 - 0.071 13.3 0.8 0.17 12.0 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1296) Glyco_hydro_129 PF11308.8 EMC81973.1 - 0.071 12.2 0.2 0.093 11.9 0.2 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases related to GH101 family, GH129 MU117 PF15474.6 EMC81973.1 - 0.072 13.9 0.1 0.12 13.2 0.1 1.4 1 0 0 1 1 1 0 Meiotically up-regulated gene family Evr1_Alr PF04777.13 EMC81973.1 - 0.21 12.1 2.1 5 7.7 1.2 2.2 1 1 1 2 2 2 0 Erv1 / Alr family IL10 PF00726.17 EMC81974.1 - 6.1e-07 29.1 0.1 7.5e-07 28.8 0.1 1.1 1 0 0 1 1 1 1 Interleukin 10 IL22 PF14565.6 EMC81974.1 - 2.2e-05 24.7 0.2 3.3e-05 24.2 0.2 1.1 1 0 0 1 1 1 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor Phospholip_A2_1 PF00068.19 EMC81974.1 - 0.018 15.5 5.0 0.026 15.0 5.0 1.1 1 0 0 1 1 1 0 Phospholipase A2 V-set PF07686.17 EMC81975.1 - 3.5e-51 172.0 13.8 5.1e-12 45.9 0.2 5.6 5 1 0 5 5 5 5 Immunoglobulin V-set domain ig PF00047.25 EMC81975.1 - 2.8e-14 53.0 16.3 0.00017 21.7 0.2 7.4 5 3 0 5 5 5 5 Immunoglobulin domain Ig_3 PF13927.6 EMC81975.1 - 9e-13 48.6 15.3 0.0049 17.4 0.2 5.7 5 1 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 EMC81975.1 - 4.3e-11 42.7 3.0 0.7 10.0 0.2 6.1 5 2 0 5 5 5 4 Immunoglobulin I-set domain Ig_4 PF16680.5 EMC81975.1 - 1.7e-07 31.4 0.2 1 9.7 0.0 5.9 5 0 0 5 5 5 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 EMC81975.1 - 5.4e-06 26.4 0.1 0.085 12.9 0.0 4.8 5 0 0 5 5 5 1 Izumo-like Immunoglobulin domain Egh16-like PF11327.8 EMC81975.1 - 0.023 15.1 0.4 6.5 7.1 0.0 3.0 3 1 0 3 3 3 0 Egh16-like virulence factor IL2 PF00715.17 EMC81975.1 - 0.2 11.6 0.0 0.49 10.3 0.0 1.7 1 0 0 1 1 1 0 Interleukin 2 OTU PF02338.19 EMC81976.1 - 1.2e-05 25.8 0.0 1.9e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease zf-C2H2_2 PF12756.7 EMC81976.1 - 0.028 14.7 0.0 0.057 13.8 0.0 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 EMC81976.1 - 0.49 10.9 2.4 3.7 8.1 0.0 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type 6PF2K PF01591.18 EMC81977.1 - 3.5e-102 340.4 0.9 5.2e-102 339.9 0.9 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EMC81977.1 - 3.2e-41 141.2 0.0 4.2e-41 140.8 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EMC81977.1 - 1.1e-07 32.1 0.0 2.6e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EMC81977.1 - 8e-05 22.2 0.0 0.00015 21.3 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_17 PF13207.6 EMC81977.1 - 0.0071 16.8 0.0 0.017 15.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain His_Phos_2 PF00328.22 EMC81977.1 - 0.059 12.7 0.0 0.09 12.1 0.0 1.2 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) Sushi PF00084.20 EMC81978.1 - 5.1e-53 177.5 35.8 2.9e-13 50.2 2.1 6.5 6 1 0 6 6 6 6 Sushi repeat (SCR repeat) TNFR_16_TM PF18422.1 EMC81978.1 - 0.14 12.1 0.8 0.29 11.1 0.8 1.6 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain cEGF PF12662.7 EMC81978.1 - 0.54 10.2 8.0 38 4.3 0.5 5.4 4 1 0 4 4 4 0 Complement Clr-like EGF-like CD34_antigen PF06365.12 EMC81979.1 - 3.1e-30 105.3 0.0 3.4e-30 105.2 0.0 1.0 1 0 0 1 1 1 1 CD34/Podocalyxin family DUF4064 PF13273.6 EMC81979.1 - 0.0062 16.8 0.0 0.0078 16.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4064) PEP-CTERM PF07589.11 EMC81979.1 - 1.6 8.9 6.1 0.47 10.6 2.9 1.8 2 0 0 2 2 2 0 PEP-CTERM motif Pkinase PF00069.25 EMC81980.1 - 1.1e-78 264.2 0.0 2e-78 263.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC81980.1 - 5.5e-35 120.9 0.0 8.2e-35 120.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC81980.1 - 1.5e-10 40.9 0.0 1.7e-08 34.2 0.0 2.1 1 1 1 2 2 2 2 Kinase-like Kdo PF06293.14 EMC81980.1 - 0.00011 21.6 0.0 0.00021 20.7 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMC81980.1 - 0.00081 18.3 0.0 0.0028 16.5 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase FTA2 PF13095.6 EMC81980.1 - 0.001 18.7 0.3 1.1 8.9 0.1 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EMC81980.1 - 0.0013 18.3 0.1 0.0025 17.4 0.1 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 EMC81980.1 - 0.0016 18.4 0.0 0.26 11.2 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Acid_phosphat_B PF03767.14 EMC81981.1 - 0.038 13.6 0.1 0.096 12.3 0.1 1.6 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) Tropomyosin_1 PF12718.7 EMC81981.1 - 0.072 13.2 10.9 0.27 11.4 0.3 3.3 3 0 0 3 3 3 0 Tropomyosin like Trans_reg_C PF00486.28 EMC81981.1 - 0.17 12.0 0.8 1.4 9.1 0.1 2.4 2 0 0 2 2 2 0 Transcriptional regulatory protein, C terminal DUF948 PF06103.11 EMC81981.1 - 0.2 11.9 10.1 0.27 11.5 0.3 3.6 3 2 0 3 3 3 0 Bacterial protein of unknown function (DUF948) zf-C4H2 PF10146.9 EMC81981.1 - 0.25 11.6 4.9 4.8 7.4 0.5 2.3 2 0 0 2 2 2 0 Zinc finger-containing protein DUF5304 PF17230.2 EMC81981.1 - 0.35 11.1 5.7 0.42 10.8 0.8 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5304) FlaC_arch PF05377.11 EMC81981.1 - 0.46 10.9 6.1 0.89 10.0 0.2 3.6 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Bacillus_HBL PF05791.11 EMC81981.1 - 0.49 10.2 8.5 5 6.9 1.2 3.1 3 0 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Laminin_II PF06009.12 EMC81981.1 - 0.62 10.1 13.3 0.88 9.6 1.0 3.4 3 1 0 3 3 3 0 Laminin Domain II Sec34 PF04136.15 EMC81981.1 - 0.76 9.7 8.1 3.2 7.6 0.1 3.5 2 1 0 3 3 3 0 Sec34-like family DUF1843 PF08898.10 EMC81981.1 - 1 9.9 6.0 0.67 10.5 0.5 3.0 4 0 0 4 4 2 0 Domain of unknown function (DUF1843) UPF0242 PF06785.11 EMC81981.1 - 1.1 9.4 6.6 1.1 9.3 0.0 2.5 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus NPV_P10 PF05531.12 EMC81981.1 - 2.8 8.5 7.6 17 5.9 0.0 4.4 2 2 3 5 5 5 0 Nucleopolyhedrovirus P10 protein TolA_bind_tri PF16331.5 EMC81981.1 - 3.5 7.8 19.1 0.81 9.8 3.4 4.2 4 0 0 4 4 4 0 TolA binding protein trimerisation DUF4795 PF16043.5 EMC81981.1 - 3.9 7.0 9.0 1.3 8.6 3.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4795) DUF4055 PF13264.6 EMC81981.1 - 7.8 6.7 8.3 1 9.5 1.1 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4055) Laminin_EGF PF00053.24 EMC81982.1 - 1e-38 131.2 67.5 7.1e-12 45.3 10.8 4.1 4 0 0 4 4 4 4 Laminin EGF domain EGF_2 PF07974.13 EMC81982.1 - 0.0066 16.8 2.4 0.0066 16.8 2.4 7.2 7 2 1 8 8 8 3 EGF-like domain adh_short PF00106.25 EMC81983.1 - 2.6e-46 157.5 1.0 3.2e-46 157.2 1.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC81983.1 - 3.5e-25 88.9 0.6 4.3e-25 88.7 0.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC81983.1 - 2.4e-07 30.9 2.7 0.0015 18.5 0.6 2.0 2 0 0 2 2 2 2 KR domain DUF1776 PF08643.10 EMC81983.1 - 0.00059 19.3 0.0 0.0036 16.7 0.0 1.8 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) THF_DHG_CYH_C PF02882.19 EMC81983.1 - 0.0042 16.4 0.2 0.013 14.8 0.0 1.8 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.20 EMC81983.1 - 0.0063 16.6 0.1 0.011 15.8 0.1 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase FMO-like PF00743.19 EMC81983.1 - 0.012 14.1 0.0 0.019 13.4 0.0 1.3 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like NAD_binding_2 PF03446.15 EMC81983.1 - 0.019 15.2 0.1 0.033 14.4 0.1 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EMC81983.1 - 0.1 12.0 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 EMC81983.1 - 0.13 12.8 0.6 0.76 10.2 0.1 2.2 3 0 0 3 3 3 0 Putative NAD(P)-binding NmrA PF05368.13 EMC81983.1 - 0.17 11.4 0.4 0.28 10.7 0.4 1.3 1 0 0 1 1 1 0 NmrA-like family tRNA_m1G_MT PF01746.21 EMC81983.1 - 0.22 11.2 0.0 0.3 10.7 0.0 1.2 1 0 0 1 1 1 0 tRNA (Guanine-1)-methyltransferase adh_short PF00106.25 EMC81984.1 - 4.4e-41 140.5 0.0 5.5e-41 140.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC81984.1 - 4e-21 75.6 0.0 4.8e-21 75.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 EMC81984.1 - 3.6e-07 29.9 0.0 5.2e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) KR PF08659.10 EMC81984.1 - 2.9e-06 27.3 0.5 0.0081 16.1 0.1 2.1 2 0 0 2 2 2 2 KR domain EF-hand_1 PF00036.32 EMC81985.1 - 1.8e-22 77.2 11.1 1.7e-06 27.1 0.0 4.4 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 EMC81985.1 - 4.2e-21 75.2 2.8 8.1e-14 51.8 0.1 3.3 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EMC81985.1 - 4.5e-20 69.8 5.3 5.6e-05 22.7 0.1 5.4 4 2 1 5 5 5 3 EF-hand domain EF-hand_8 PF13833.6 EMC81985.1 - 2.5e-15 56.1 2.5 7.2e-07 29.0 0.1 3.9 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EMC81985.1 - 2.6e-15 55.1 10.0 0.00012 21.4 0.6 4.6 5 0 0 5 5 5 3 EF hand SPARC_Ca_bdg PF10591.9 EMC81985.1 - 7.4e-07 29.5 0.4 0.27 11.6 0.0 3.3 1 1 2 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EMC81985.1 - 0.012 15.5 1.7 3 7.8 0.1 2.9 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EMC81986.1 - 2.9e-22 76.5 11.5 9.3e-07 28.0 0.2 4.9 4 1 1 5 5 5 3 EF hand EF-hand_7 PF13499.6 EMC81986.1 - 3.1e-22 78.8 3.3 7.5e-14 51.9 0.3 3.4 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EMC81986.1 - 4.1e-20 69.9 6.8 2.4e-05 23.9 0.0 5.1 4 2 1 5 5 5 3 EF-hand domain EF-hand_8 PF13833.6 EMC81986.1 - 4e-18 65.0 1.9 2.6e-08 33.6 0.5 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EMC81986.1 - 1e-13 50.0 11.3 1.1e-05 24.6 0.9 4.8 5 1 1 6 6 6 3 EF hand SPARC_Ca_bdg PF10591.9 EMC81986.1 - 2.5e-07 31.0 0.6 0.00069 19.9 0.1 3.0 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EMC81986.1 - 1.6e-05 24.8 2.8 0.31 11.0 0.0 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 EMC81986.1 - 0.00011 22.3 1.3 0.027 14.7 0.4 3.2 3 1 0 3 3 3 1 Dockerin type I domain VCBS PF13517.6 EMC81986.1 - 0.06 13.9 2.1 9.4 6.9 0.1 3.2 2 1 2 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DUF4891 PF16232.5 EMC81986.1 - 0.065 13.8 0.0 5 7.7 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4891) Caleosin PF05042.13 EMC81986.1 - 0.071 13.0 0.7 8.5 6.3 0.0 2.9 1 1 2 3 3 3 0 Caleosin related protein PUA_3 PF17785.1 EMC81987.1 - 0.0079 16.0 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain WD40 PF00400.32 EMC81988.1 - 1.6e-10 41.4 10.2 0.00099 19.9 0.2 4.5 4 0 0 4 4 4 3 WD domain, G-beta repeat Peptidase_S24 PF00717.23 EMC81988.1 - 0.0035 17.3 0.0 0.0065 16.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like TFIIIC_delta PF12657.7 EMC81988.1 - 0.0086 16.0 0.1 0.024 14.5 0.1 1.6 1 1 0 1 1 1 1 Transcription factor IIIC subunit delta N-term NinE PF05322.11 EMC81988.1 - 0.1 12.5 0.1 0.31 11.0 0.1 1.9 1 0 0 1 1 1 0 NINE Protein Mt_ATP-synt_B PF05405.14 EMC81989.1 - 8.9e-51 171.7 8.3 1e-50 171.5 8.3 1.0 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) TraQ PF09679.10 EMC81989.1 - 0.0031 17.4 0.0 0.0058 16.5 0.0 1.5 1 0 0 1 1 1 1 Type-F conjugative transfer system pilin chaperone (TraQ) 7tm_1 PF00001.21 EMC81990.1 - 2.9e-49 167.8 23.1 3.4e-49 167.5 23.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC81990.1 - 1.1e-12 47.9 24.3 1.3e-12 47.6 24.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC81990.1 - 1.3e-10 41.5 21.2 2.8e-10 40.4 21.1 1.5 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC81990.1 - 0.00018 21.2 18.5 0.00018 21.2 18.5 2.4 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Se-cys_synth_N PF12390.8 EMC81991.1 - 2.2 8.5 17.2 6.8 7.0 0.1 5.3 6 0 0 6 6 6 0 Selenocysteine synthase N terminal Collagen PF01391.18 EMC81992.1 - 0.0021 17.8 7.0 0.014 15.1 5.0 2.9 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) SH3_19 PF18597.1 EMC81993.1 - 0.00016 21.4 0.2 0.0006 19.6 0.1 2.1 2 0 0 2 2 2 1 Myosin X N-terminal SH3 domain Myosin_head PF00063.21 EMC81993.1 - 0.00018 19.9 0.0 0.00024 19.5 0.0 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) 7tm_2 PF00002.24 EMC81994.1 - 5.2e-62 209.3 17.5 7.1e-62 208.9 17.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) TSP_1 PF00090.19 EMC81994.1 - 2.8e-49 165.1 81.8 1.1e-13 51.1 7.2 6.0 6 0 0 6 6 6 5 Thrombospondin type 1 domain GAIN PF16489.5 EMC81994.1 - 1.4e-32 112.9 0.6 1.8e-31 109.2 0.5 2.5 2 1 0 2 2 2 1 GPCR-Autoproteolysis INducing (GAIN) domain GPS PF01825.21 EMC81994.1 - 1.6e-11 44.5 0.5 1.6e-11 44.5 0.5 3.0 3 0 0 3 3 3 1 GPCR proteolysis site, GPS, motif DUF3422 PF11902.8 EMC81994.1 - 0.21 10.7 0.0 0.35 10.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3422) Arc_C PF18162.1 EMC81995.1 - 7.4e-47 157.1 1.2 2e-46 155.8 1.2 1.8 1 0 0 1 1 1 1 Arc C-lobe Retrotrans_gag PF03732.17 EMC81995.1 - 0.0011 19.2 2.1 0.0022 18.2 0.5 2.3 2 0 0 2 2 2 1 Retrotransposon gag protein DUF842 PF05811.13 EMC81995.1 - 0.0096 15.6 0.3 0.037 13.7 0.3 1.9 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) KxDL PF10241.9 EMC81995.1 - 0.017 15.4 0.4 6.5 7.1 0.1 2.9 3 0 0 3 3 3 0 Uncharacterized conserved protein THOC7 PF05615.13 EMC81995.1 - 0.022 15.1 0.4 0.04 14.2 0.4 1.4 1 0 0 1 1 1 0 Tho complex subunit 7 FH2 PF02181.23 EMC81995.1 - 0.036 13.2 0.5 0.066 12.3 0.5 1.4 1 0 0 1 1 1 0 Formin Homology 2 Domain SYCE1 PF15233.6 EMC81995.1 - 0.16 12.0 5.3 0.61 10.1 0.2 2.7 2 1 0 2 2 2 0 Synaptonemal complex central element protein 1 ThiD2 PF17792.1 EMC81995.1 - 0.19 12.2 1.1 0.39 11.2 1.1 1.5 1 0 0 1 1 1 0 ThiD2 family DDE_Tnp_ISL3 PF01610.17 EMC81995.1 - 0.32 10.7 5.6 9.3 5.9 2.4 2.7 3 0 0 3 3 3 0 Transposase Mab-21 PF03281.14 EMC81997.1 - 2e-13 50.3 0.7 2.9e-12 46.5 0.7 2.1 1 1 0 1 1 1 1 Mab-21 protein TFIIE-A_C PF11521.8 EMC81997.1 - 0.024 14.9 0.9 0.052 13.8 0.9 1.6 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha FERM_M PF00373.18 EMC81998.1 - 2.2e-47 160.3 0.0 1.1e-46 158.1 0.0 2.2 1 1 0 1 1 1 1 FERM central domain Kindlin_2_N PF18124.1 EMC81998.1 - 5.2e-37 125.9 5.1 1.5e-36 124.4 5.1 1.9 1 0 0 1 1 1 1 Kindlin-2 N-terminal domain PH PF00169.29 EMC81998.1 - 7.2e-10 39.3 0.1 1.9e-09 38.0 0.1 1.7 1 0 0 1 1 1 1 PH domain FERM_N PF09379.10 EMC81998.1 - 0.0017 18.3 0.0 0.0058 16.5 0.0 2.0 1 1 0 1 1 1 1 FERM N-terminal domain TGFb_propeptide PF00688.18 EMC81999.1 - 7.2e-55 186.4 1.1 1e-54 185.9 1.1 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 EMC81999.1 - 8.3e-34 116.7 0.5 1.7e-33 115.7 0.5 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain Tnp_DNA_bind PF14706.6 EMC81999.1 - 0.062 13.2 0.0 2.6 8.0 0.0 2.7 2 0 0 2 2 2 0 Transposase DNA-binding CDKN3 PF05706.12 EMC82000.1 - 3.6e-71 238.2 1.8 4.1e-71 238.0 1.8 1.0 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) DSPc PF00782.20 EMC82000.1 - 4.1e-05 23.4 0.0 7.2e-05 22.6 0.0 1.4 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC82000.1 - 0.0011 18.6 0.0 0.0012 18.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase ANF_receptor PF01094.28 EMC82000.1 - 0.0038 16.4 0.0 0.0048 16.0 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Connexin PF00029.19 EMC82001.1 - 4.1e-109 363.8 4.6 6.5e-109 363.2 4.6 1.3 1 0 0 1 1 1 1 Connexin Connexin40_C PF16791.5 EMC82001.1 - 7.1 8.0 10.9 0.6 11.4 5.0 2.3 2 1 0 2 2 2 0 Connexin 40 C-terminal domain MEIOC PF15189.6 EMC82004.1 - 1.1e-84 282.1 1.5 1.3e-84 281.9 1.5 1.0 1 0 0 1 1 1 1 Meiosis-specific coiled-coil domain-containing protein MEIOC CAMSAP_CC1 PF17095.5 EMC82004.1 - 0.058 13.3 0.2 0.14 12.0 0.2 1.6 1 0 0 1 1 1 0 Spectrin-binding region of Ca2+-Calmodulin AAA_11 PF13086.6 EMC82005.1 - 0.036 13.9 5.8 0.035 13.9 5.8 1.1 1 0 0 1 1 1 0 AAA domain Presenilin PF01080.17 EMC82005.1 - 0.16 10.7 9.3 0.18 10.6 9.3 1.1 1 0 0 1 1 1 0 Presenilin Rtf2 PF04641.12 EMC82005.1 - 0.64 9.3 13.3 0.83 9.0 13.3 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger RR_TM4-6 PF06459.12 EMC82005.1 - 0.75 9.6 15.0 0.95 9.2 15.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.17 EMC82005.1 - 1.3 9.1 3.9 1.6 8.8 3.9 1.1 1 0 0 1 1 1 0 DDHD domain NPR3 PF03666.13 EMC82005.1 - 2.3 6.9 14.5 2.9 6.6 14.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CDC45 PF02724.14 EMC82005.1 - 3 6.0 19.9 3.7 5.7 19.9 1.1 1 0 0 1 1 1 0 CDC45-like protein RNA_polI_A34 PF08208.11 EMC82005.1 - 3.4 7.7 22.1 4.7 7.2 22.1 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Hid1 PF12722.7 EMC82005.1 - 4.3 5.3 6.5 5.2 5.1 6.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Spore_coat_CotO PF14153.6 EMC82005.1 - 7.9 6.4 19.2 11 5.9 19.2 1.1 1 0 0 1 1 1 0 Spore coat protein CotO p450 PF00067.22 EMC82006.1 - 2e-45 155.4 0.1 6.3e-45 153.8 0.1 1.7 1 1 0 1 1 1 1 Cytochrome P450 HIG_1_N PF04588.13 EMC82007.1 - 9.8e-17 60.9 2.4 9.8e-17 60.9 2.4 1.5 1 1 0 1 1 1 1 Hypoxia induced protein conserved region DUF998 PF06197.13 EMC82007.1 - 0.054 13.1 0.2 0.064 12.9 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF998) DUF3848 PF12959.7 EMC82008.1 - 0.019 15.0 2.3 0.019 15.0 2.3 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3848) Pox_A_type_inc PF04508.12 EMC82008.1 - 0.025 14.4 12.2 1.1 9.2 0.0 5.7 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat BRI3BP PF14965.6 EMC82008.1 - 6.1 6.3 10.5 14 5.1 1.1 3.6 3 0 0 3 3 3 0 Negative regulator of p53/TP53 MBOAT PF03062.19 EMC82009.1 - 2e-13 50.4 16.3 3.7e-13 49.6 16.3 1.5 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family UCR_6-4kD PF08997.10 EMC82009.1 - 0.36 10.8 2.7 1.3 9.0 0.1 2.9 3 0 0 3 3 3 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein BTB PF00651.31 EMC82010.1 - 1.4e-35 121.9 1.6 5.1e-35 120.1 0.6 2.2 2 0 0 2 2 2 1 BTB/POZ domain Kelch_1 PF01344.25 EMC82010.1 - 2e-35 120.1 0.1 4.5e-10 38.9 0.0 5.7 6 0 0 6 6 6 4 Kelch motif BACK PF07707.15 EMC82010.1 - 3.1e-28 97.9 1.6 7.7e-28 96.6 0.2 2.4 3 0 0 3 3 3 1 BTB And C-terminal Kelch Kelch_6 PF13964.6 EMC82010.1 - 3.9e-28 96.8 0.0 7.9e-07 29.1 0.0 5.4 2 1 3 5 5 5 5 Kelch motif Kelch_4 PF13418.6 EMC82010.1 - 7.9e-23 80.2 0.0 9.3e-07 28.8 0.0 5.7 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_3 PF13415.6 EMC82010.1 - 1e-15 57.6 0.1 9e-05 22.7 0.0 5.5 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC82010.1 - 2.3e-14 53.0 0.7 0.0039 17.1 0.1 5.1 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 EMC82010.1 - 5.2e-14 51.6 2.0 0.01 15.8 0.0 5.5 5 0 0 5 5 5 4 Kelch motif DUF3342 PF11822.8 EMC82010.1 - 0.00027 21.1 1.0 0.2 11.9 0.2 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF3342) Pro_isomerase PF00160.21 EMC82012.1 - 8e-47 159.4 0.1 2e-46 158.1 0.1 1.8 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SR-25 PF10500.9 EMC82012.1 - 0.00018 21.2 25.1 0.00018 21.2 25.1 10.8 4 3 6 10 10 10 1 Nuclear RNA-splicing-associated protein Longin PF13774.6 EMC82013.1 - 1.9e-16 59.9 0.1 3.4e-16 59.1 0.1 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain 7tm_2 PF00002.24 EMC82014.1 - 7.1e-94 313.7 23.4 9.4e-94 313.3 23.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 EMC82014.1 - 3.2e-22 78.6 3.5 6.5e-22 77.6 3.5 1.5 1 0 0 1 1 1 1 Hormone receptor domain NB PF04159.13 EMC82014.1 - 0.51 10.4 2.4 3.7 7.6 0.3 2.4 2 0 0 2 2 2 0 NB glycoprotein DUF717 PF05338.12 EMC82015.1 - 0.031 14.4 2.3 1.8 8.7 0.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF717) 7tm_2 PF00002.24 EMC82016.1 - 2.5e-85 285.7 18.5 3.1e-85 285.4 18.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 EMC82016.1 - 3.1e-19 69.0 2.0 3.1e-19 69.0 2.0 1.9 2 0 0 2 2 2 1 Hormone receptor domain Ac76 PF05814.11 EMC82016.1 - 1 9.4 4.5 1 9.4 0.1 2.9 3 0 0 3 3 3 0 Orf76 (Ac76) 7tm_2 PF00002.24 EMC82017.1 - 6.5e-94 313.8 16.3 6.5e-94 313.8 16.3 1.8 2 1 0 2 2 2 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 EMC82017.1 - 3.2e-27 94.6 2.6 3.2e-27 94.6 2.6 2.3 2 0 0 2 2 2 1 Hormone receptor domain Insulin_TMD PF17870.1 EMC82017.1 - 0.056 13.5 0.6 0.22 11.6 0.6 2.0 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment 7tm_2 PF00002.24 EMC82018.1 - 1.4e-84 283.2 19.1 1.8e-84 282.9 19.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 EMC82018.1 - 1.3e-20 73.4 1.0 3.1e-20 72.2 1.0 1.7 1 0 0 1 1 1 1 Hormone receptor domain Dicty_CAR PF05462.11 EMC82018.1 - 0.00027 20.2 16.1 0.00041 19.6 16.1 1.3 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor MIP PF00230.20 EMC82019.1 - 5e-80 268.5 10.0 5.8e-80 268.2 10.0 1.0 1 0 0 1 1 1 1 Major intrinsic protein Ank_2 PF12796.7 EMC82020.1 - 4.3e-43 145.8 2.2 4.3e-15 56.1 0.1 4.3 1 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC82020.1 - 7.5e-33 112.5 3.0 3.6e-11 43.4 0.0 6.2 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 EMC82020.1 - 2.5e-30 103.6 5.4 0.00017 21.9 0.0 6.9 7 0 0 7 7 7 6 Ankyrin repeat Ank_3 PF13606.6 EMC82020.1 - 3.1e-29 97.8 2.1 0.00023 21.3 0.0 8.1 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 EMC82020.1 - 2.7e-23 81.7 4.8 1.1e-05 25.6 0.1 4.9 2 2 2 4 4 4 4 Ankyrin repeats (many copies) SAM_1 PF00536.30 EMC82020.1 - 9e-10 38.9 0.1 2.4e-09 37.5 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC82020.1 - 4.4e-07 29.9 0.1 1e-06 28.7 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Glycos_transf_2 PF00535.26 EMC82021.1 - 1.5e-37 129.0 0.0 2e-37 128.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_7C PF02709.14 EMC82021.1 - 6.1e-06 25.8 0.1 1.2e-05 24.8 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 EMC82021.1 - 7.7e-06 25.6 0.0 2.1e-05 24.1 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase like family 2 7tm_3 PF00003.22 EMC82023.1 - 2.9e-50 171.2 13.4 4.3e-50 170.7 13.4 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.28 EMC82023.1 - 9.1e-36 123.7 0.1 1.3e-35 123.2 0.1 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region GBR2_CC PF18455.1 EMC82023.1 - 4e-26 90.9 3.3 8.4e-26 89.8 3.3 1.6 1 0 0 1 1 1 1 Gamma-aminobutyric acid type B receptor subunit 2 coiled-coil domain UPF0242 PF06785.11 EMC82023.1 - 0.035 14.2 0.1 0.084 13.0 0.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus HOOK PF05622.12 EMC82023.1 - 0.06 11.5 5.9 0.087 11.0 5.9 1.1 1 0 0 1 1 1 0 HOOK protein Lectin_N PF03954.14 EMC82023.1 - 0.37 10.6 2.2 0.88 9.3 2.2 1.6 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain E2F_CC-MB PF16421.5 EMC82023.1 - 0.57 10.6 3.9 1.4 9.4 3.3 1.9 2 0 0 2 2 2 0 E2F transcription factor CC-MB domain DUF2976 PF11190.8 EMC82023.1 - 5.2 6.9 8.6 7.4 6.5 1.9 3.7 3 1 0 3 3 3 0 Protein of unknown function (DUF2976) Cation_ATPase_C PF00689.21 EMC82023.1 - 5.3 6.7 12.3 0.51 10.0 1.0 2.8 2 1 1 3 3 3 0 Cation transporting ATPase, C-terminus WD40 PF00400.32 EMC82024.1 - 1.6e-43 145.8 32.4 0.00031 21.5 1.7 12.7 13 0 0 13 13 13 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC82024.1 - 1.2e-05 25.5 3.3 2.4 8.5 0.1 6.7 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain bHLH-MYC_N PF14215.6 EMC82024.1 - 0.031 14.6 0.1 0.11 12.8 0.1 1.9 1 0 0 1 1 1 0 bHLH-MYC and R2R3-MYB transcription factors N-terminal eIF2A PF08662.11 EMC82024.1 - 0.054 13.4 3.9 6.5 6.6 0.1 3.8 3 1 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A Vinculin PF01044.19 EMC82025.1 - 4.4e-53 180.8 20.2 8.1e-33 113.8 5.3 3.5 3 1 0 3 3 3 3 Vinculin family COG5 PF10392.9 EMC82025.1 - 0.4 10.8 9.4 0.2 11.9 2.5 3.7 3 2 1 4 4 4 0 Golgi transport complex subunit 5 WXG100 PF06013.12 EMC82025.1 - 1.1 9.5 9.2 0.06 13.6 1.2 3.2 3 0 0 3 3 3 0 Proteins of 100 residues with WXG GCV_H PF01597.19 EMC82026.1 - 5.3e-08 32.8 0.0 9.5e-08 32.0 0.0 1.4 2 0 0 2 2 2 1 Glycine cleavage H-protein Zip PF02535.22 EMC82027.1 - 6.8e-96 321.4 22.5 6.8e-96 321.4 22.5 3.3 2 2 0 2 2 2 1 ZIP Zinc transporter Patched PF02460.18 EMC82028.1 - 1.4e-89 301.3 18.3 2e-89 300.8 18.3 1.1 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 EMC82028.1 - 1.1e-19 70.8 3.0 1.1e-19 70.8 3.0 2.5 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Phage_holin_3_6 PF07332.11 EMC82028.1 - 4.1 7.5 8.2 17 5.5 0.0 3.2 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III SET PF00856.28 EMC82029.1 - 0.00013 22.3 0.2 0.00017 22.0 0.2 1.1 1 0 0 1 1 1 1 SET domain IL17R_D_N PF16742.5 EMC82030.1 - 6e-64 213.6 0.0 1.2e-63 212.7 0.0 1.5 1 0 0 1 1 1 1 N-terminus of interleukin 17 receptor D SEFIR PF08357.11 EMC82030.1 - 1.3e-55 187.8 0.3 2.6e-55 186.8 0.3 1.5 1 0 0 1 1 1 1 SEFIR domain TIR_2 PF13676.6 EMC82030.1 - 0.0051 17.4 0.0 0.013 16.1 0.0 1.7 1 0 0 1 1 1 1 TIR domain fn3 PF00041.21 EMC82030.1 - 0.025 14.9 0.0 9.1 6.7 0.0 2.8 3 0 0 3 3 3 0 Fibronectin type III domain DUF2141 PF09912.9 EMC82030.1 - 0.038 13.9 0.0 0.086 12.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2141) DUF1863 PF08937.11 EMC82030.1 - 0.066 13.5 0.1 0.18 12.1 0.1 1.8 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) Homeodomain PF00046.29 EMC82031.1 - 1.8e-23 82.1 2.1 2.8e-23 81.5 1.0 1.9 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 EMC82031.1 - 0.0037 17.1 0.2 0.013 15.4 0.1 1.9 2 0 0 2 2 2 1 Homeobox KN domain AAA_6 PF12774.7 EMC82032.1 - 1.1e-156 520.8 0.0 6.1e-155 515.1 0.0 3.3 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EMC82032.1 - 1.8e-139 465.3 18.5 1.8e-139 465.3 18.5 2.9 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 Dynein_C PF18199.1 EMC82032.1 - 2.5e-116 388.2 0.0 8.6e-116 386.5 0.0 2.0 2 0 0 2 2 1 1 Dynein heavy chain C-terminal domain AAA_8 PF12780.7 EMC82032.1 - 3.2e-104 347.9 0.6 7.9e-103 343.3 0.0 3.5 3 0 0 3 3 3 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 EMC82032.1 - 7.4e-90 299.9 2.4 7.4e-90 299.9 2.4 5.2 7 0 0 7 7 6 1 ATP-binding dynein motor region AAA_7 PF12775.7 EMC82032.1 - 1.6e-84 281.9 0.1 2.1e-81 271.8 0.0 3.9 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_lid_11 PF18198.1 EMC82032.1 - 2.1e-62 209.8 0.0 8.8e-62 207.7 0.0 2.1 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 EMC82032.1 - 1.1e-49 167.4 0.0 2.9e-48 162.9 0.0 3.1 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 EMC82032.1 - 5e-48 163.9 13.5 5e-48 163.9 13.5 1.7 2 0 0 2 2 1 1 Microtubule-binding stalk of dynein motor Dynein_AAA_lid PF17852.1 EMC82032.1 - 3.1e-30 104.9 1.2 2.7e-29 101.8 0.0 3.2 3 0 0 3 3 2 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 EMC82032.1 - 4.1e-18 65.7 0.0 4.7e-07 29.9 0.0 5.6 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 EMC82032.1 - 1.5e-16 60.4 0.7 6.1e-16 58.5 0.7 2.1 1 0 0 1 1 1 1 AAA+ lid domain AAA PF00004.29 EMC82032.1 - 1.9e-08 34.8 3.4 0.021 15.3 0.0 5.6 5 0 0 5 5 5 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EMC82032.1 - 2.5e-06 28.0 0.0 0.16 12.4 0.0 5.1 4 0 0 4 4 4 1 AAA ATPase domain AAA_22 PF13401.6 EMC82032.1 - 1.1e-05 25.7 1.6 1.7 8.9 0.0 5.7 5 0 0 5 5 5 1 AAA domain RNA_helicase PF00910.22 EMC82032.1 - 0.00012 22.4 0.2 7.4 7.0 0.0 4.7 4 0 0 4 4 4 0 RNA helicase NACHT PF05729.12 EMC82032.1 - 0.00062 19.7 0.0 4.6 7.1 0.0 3.9 3 0 0 3 3 3 1 NACHT domain AAA_24 PF13479.6 EMC82032.1 - 0.00065 19.5 0.1 1.3 8.7 0.0 3.9 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 EMC82032.1 - 0.007 16.9 1.0 1.1 9.8 0.0 4.5 4 0 0 4 4 3 1 AAA domain ABC_tran PF00005.27 EMC82032.1 - 0.0075 16.8 0.1 11 6.6 0.0 3.7 3 0 0 3 3 2 0 ABC transporter T2SSE PF00437.20 EMC82032.1 - 0.037 13.1 0.1 0.69 8.9 0.0 2.7 3 0 0 3 3 3 0 Type II/IV secretion system protein DUF4187 PF13821.6 EMC82032.1 - 0.082 12.7 0.5 0.32 10.8 0.5 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4187) AAA_30 PF13604.6 EMC82032.1 - 0.085 12.6 0.2 6.9 6.3 0.1 3.2 3 0 0 3 3 3 0 AAA domain Roc PF08477.13 EMC82032.1 - 0.1 12.8 0.0 37 4.6 0.0 3.8 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 EMC82032.1 - 0.14 12.3 0.1 80 3.4 0.0 3.7 3 0 0 3 3 3 0 AAA domain ATPase_2 PF01637.18 EMC82032.1 - 0.21 11.5 3.9 0.27 11.1 0.0 3.5 3 0 0 3 3 1 0 ATPase domain predominantly from Archaea TsaE PF02367.17 EMC82032.1 - 0.94 9.5 3.3 45 4.1 0.0 3.9 4 0 0 4 4 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Peptidase_M3_N PF08439.10 EMC82032.1 - 1.3 9.3 7.1 9.1 6.6 0.2 4.2 3 0 0 3 3 2 0 Oligopeptidase F AAA_29 PF13555.6 EMC82032.1 - 2.1 8.1 9.8 3 7.7 0.0 3.7 4 0 0 4 4 3 0 P-loop containing region of AAA domain AAA_25 PF13481.6 EMC82032.1 - 2.3 7.8 4.2 21 4.6 0.0 4.0 5 0 0 5 5 4 0 AAA domain Arf PF00025.21 EMC82033.1 - 6.6e-73 243.9 0.2 7.2e-73 243.7 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EMC82033.1 - 1.6e-14 53.7 0.0 1.9e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EMC82033.1 - 2.1e-14 53.4 0.0 2.2e-14 53.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC82033.1 - 3.3e-14 53.1 0.0 4.9e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EMC82033.1 - 4e-11 42.7 1.1 1.8e-09 37.2 0.2 2.4 1 1 1 2 2 2 1 G-protein alpha subunit Gtr1_RagA PF04670.12 EMC82033.1 - 1.1e-10 41.3 0.0 1.2e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMC82033.1 - 1e-05 25.5 0.0 1.5e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EMC82033.1 - 0.022 14.1 0.1 0.034 13.5 0.1 1.5 1 1 0 1 1 1 0 6-phosphofructo-2-kinase CRISPR_Cas2 PF09827.9 EMC82033.1 - 0.023 14.9 0.0 0.035 14.3 0.0 1.3 1 0 0 1 1 1 0 CRISPR associated protein Cas2 LepB_N PF18640.1 EMC82033.1 - 0.11 12.1 0.0 0.14 11.8 0.0 1.1 1 0 0 1 1 1 0 LepB N-terminal domain SPA PF08616.10 EMC82034.1 - 2.2e-16 59.8 0.1 4.9e-15 55.5 0.0 2.5 2 0 0 2 2 2 1 Stabilization of polarity axis DENN PF02141.21 EMC82034.1 - 1.2e-06 28.6 3.3 1.2e-06 28.6 3.3 2.2 2 1 0 2 2 2 1 DENN (AEX-3) domain Avl9 PF09794.9 EMC82034.1 - 0.002 16.9 0.0 0.0041 15.9 0.0 1.5 1 0 0 1 1 1 1 Transport protein Avl9 RAM PF15320.6 EMC82034.1 - 0.18 12.4 0.1 0.42 11.3 0.1 1.6 1 0 0 1 1 1 0 mRNA cap methylation, RNMT-activating mini protein FHA PF00498.26 EMC82035.1 - 1.1e-17 64.1 0.0 2.8e-17 62.8 0.0 1.8 1 0 0 1 1 1 1 FHA domain GAS PF13851.6 EMC82035.1 - 3.7e-05 23.2 109.9 0.0038 16.6 8.5 6.5 3 2 3 6 6 6 4 Growth-arrest specific micro-tubule binding MscS_porin PF12795.7 EMC82035.1 - 0.0007 19.2 21.8 0.0007 19.2 21.8 5.7 2 2 3 5 5 5 2 Mechanosensitive ion channel porin domain HALZ PF02183.18 EMC82035.1 - 0.008 16.4 1.1 0.008 16.4 1.1 9.2 8 1 1 9 9 9 1 Homeobox associated leucine zipper Fib_alpha PF08702.10 EMC82035.1 - 0.0085 16.3 10.1 0.0085 16.3 10.1 6.0 2 2 3 6 6 6 4 Fibrinogen alpha/beta chain family SKA2 PF16740.5 EMC82035.1 - 0.011 15.5 5.5 0.011 15.5 5.5 7.9 2 2 3 7 7 7 0 Spindle and kinetochore-associated protein 2 T3SSipB PF16535.5 EMC82035.1 - 0.011 16.2 8.1 0.011 16.2 8.1 5.9 2 2 3 6 6 6 0 Type III cell invasion protein SipB BRE1 PF08647.11 EMC82035.1 - 0.014 15.4 11.8 0.014 15.4 11.8 8.5 4 3 3 7 7 7 0 BRE1 E3 ubiquitin ligase DUF3138 PF11336.8 EMC82035.1 - 0.19 10.3 5.2 0.093 11.3 1.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) Filamin PF00630.19 EMC82036.1 - 0 1259.0 51.7 5e-20 72.2 0.0 24.1 24 0 0 24 24 24 24 Filamin/ABP280 repeat CH PF00307.31 EMC82036.1 - 3.2e-18 65.9 0.0 1.8e-14 53.8 0.0 2.6 2 0 0 2 2 2 2 Calponin homology (CH) domain Big_3_5 PF16640.5 EMC82036.1 - 2.4e-16 59.7 30.2 0.11 12.7 1.1 14.1 14 0 0 14 14 14 5 Bacterial Ig-like domain (group 3) Invasin_D3 PF09134.10 EMC82036.1 - 4.4e-16 59.0 19.6 0.027 14.8 0.0 11.0 13 0 0 13 13 12 5 Invasin, domain 3 Y_Y_Y PF07495.13 EMC82036.1 - 9.2e-16 57.6 26.0 0.42 10.6 0.0 14.6 16 0 0 16 16 15 4 Y_Y_Y domain DUF5060 PF16586.5 EMC82036.1 - 1e-11 45.0 2.0 2.2 8.7 0.0 11.4 15 0 0 15 15 13 2 Domain of unknown function (DUF5060) YtkA PF13115.6 EMC82036.1 - 3.9e-09 37.0 14.0 4.7 7.9 0.1 12.9 16 0 0 16 16 13 1 YtkA-like EMP24_GP25L PF01105.24 EMC82036.1 - 7.8e-05 22.7 0.2 60 3.5 0.0 7.7 10 0 0 10 10 10 0 emp24/gp25L/p24 family/GOLD BatD PF13584.6 EMC82036.1 - 9.8e-05 21.3 0.4 0.22 10.3 0.0 3.4 4 0 0 4 4 4 2 Oxygen tolerance DUF2141 PF09912.9 EMC82036.1 - 0.00028 20.8 2.8 47 3.9 0.0 7.1 9 0 0 9 9 9 0 Uncharacterized protein conserved in bacteria (DUF2141) Big_1 PF02369.16 EMC82036.1 - 0.0032 17.4 8.2 72 3.5 0.1 8.4 9 0 0 9 9 9 0 Bacterial Ig-like domain (group 1) Inhibitor_I42 PF09394.10 EMC82036.1 - 0.0065 16.8 3.5 6.3 7.3 0.0 6.4 7 0 0 7 7 7 1 Chagasin family peptidase inhibitor I42 PapC_N PF13954.6 EMC82036.1 - 0.0081 16.2 0.0 5.4 7.0 0.0 5.3 6 0 0 6 6 6 1 PapC N-terminal domain Cadherin_5 PF17892.1 EMC82036.1 - 0.052 13.5 9.0 40 4.3 0.1 6.8 7 0 0 7 7 7 0 Cadherin-like domain PEGA PF08308.11 EMC82036.1 - 0.15 12.0 5.8 1.2e+02 2.7 0.2 7.4 7 0 0 7 7 7 0 PEGA domain Exo_endo_phos PF03372.23 EMC82037.1 - 1e-12 48.1 0.0 1.2e-12 47.9 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 EMC82037.1 - 0.0077 16.1 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Peptidase_M16 PF00675.20 EMC82038.1 - 1e-51 174.9 0.1 1.6e-51 174.2 0.1 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EMC82038.1 - 3.8e-37 128.1 0.0 4.8e-36 124.5 0.0 2.2 2 0 0 2 2 2 1 Peptidase M16 inactive domain Virulence_RhuM PF13310.6 EMC82038.1 - 0.048 12.9 0.0 5.8 6.1 0.0 2.2 2 0 0 2 2 2 0 Virulence protein RhuM family M16C_assoc PF08367.11 EMC82038.1 - 0.057 12.5 0.0 0.084 12.0 0.0 1.2 1 0 0 1 1 1 0 Peptidase M16C associated PvlArgDC PF01862.16 EMC82038.1 - 0.094 12.5 0.1 0.17 11.7 0.1 1.4 1 0 0 1 1 1 0 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) SAP30_Sin3_bdg PF13867.6 EMC82038.1 - 0.13 12.6 0.0 27 5.2 0.0 2.5 2 0 0 2 2 2 0 Sin3 binding region of histone deacetylase complex subunit SAP30 Kunitz_BPTI PF00014.23 EMC82039.1 - 5.9e-22 77.6 5.0 6.5e-22 77.5 5.0 1.0 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Adaptin_N PF01602.20 EMC82040.1 - 2.7e-129 432.1 11.7 3.4e-129 431.8 11.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 EMC82040.1 - 1.9e-59 200.1 0.5 4.4e-59 199.0 0.5 1.7 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 EMC82040.1 - 1.9e-38 131.1 0.0 4.3e-38 130.0 0.0 1.7 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 EMC82040.1 - 4.3e-18 65.5 0.0 3.8e-08 33.6 0.0 6.0 3 2 3 6 6 6 3 HEAT repeats Cnd1 PF12717.7 EMC82040.1 - 3.6e-11 43.4 12.2 0.04 14.0 1.7 5.5 3 1 0 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EMC82040.1 - 1.2e-05 25.2 4.3 8.9 6.9 0.0 7.0 7 0 0 7 7 7 1 HEAT repeat HEAT_EZ PF13513.6 EMC82040.1 - 0.00012 22.4 1.1 0.5 10.9 0.1 3.4 3 0 0 3 3 3 2 HEAT-like repeat HEAT_PBS PF03130.16 EMC82040.1 - 0.066 13.9 1.3 29 5.7 0.0 4.6 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat Arm PF00514.23 EMC82040.1 - 0.13 12.3 0.1 6.7 6.9 0.0 3.9 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat UNC45-central PF11701.8 EMC82040.1 - 0.3 11.1 4.5 0.45 10.5 0.2 3.1 4 0 0 4 4 4 0 Myosin-binding striated muscle assembly central SRAP PF02586.14 EMC82041.1 - 3.1e-57 193.6 0.0 5.6e-57 192.8 0.0 1.4 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) Histone_H2A_C PF16211.5 EMC82042.1 - 3.6e-21 74.6 1.8 6.3e-21 73.8 1.8 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EMC82042.1 - 5.1e-17 62.5 0.0 6.6e-17 62.1 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC82042.1 - 6e-05 23.3 0.0 8.1e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Linker_histone PF00538.19 EMC82043.1 - 4.9e-19 68.5 0.3 9.2e-19 67.6 0.3 1.4 1 0 0 1 1 1 1 linker histone H1 and H5 family DUF2572 PF10833.8 EMC82043.1 - 0.048 13.4 0.7 0.063 13.0 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) EGF_CA PF07645.15 EMC82044.1 - 1.9e-14 53.5 31.8 3.9e-11 43.0 11.1 7.2 4 2 3 7 7 7 2 Calcium-binding EGF domain DUF3456 PF11938.8 EMC82044.1 - 4.8e-06 27.2 6.7 0.00027 21.5 1.7 3.2 3 1 1 4 4 4 2 TLR4 regulator and MIR-interacting MSAP VSP PF03302.13 EMC82044.1 - 0.00021 20.3 61.6 0.03 13.2 23.2 3.2 1 1 1 2 2 2 2 Giardia variant-specific surface protein Plasmod_Pvs28 PF06247.11 EMC82044.1 - 0.0017 18.6 10.8 0.0017 18.6 10.8 5.5 3 2 0 3 3 3 1 Pvs28 EGF domain EGF PF00008.27 EMC82044.1 - 0.0018 18.6 0.8 0.0018 18.6 0.8 6.7 8 1 1 9 9 9 3 EGF-like domain cEGF PF12662.7 EMC82044.1 - 0.0022 17.9 11.7 0.0082 16.1 2.8 6.6 5 1 0 5 5 5 2 Complement Clr-like EGF-like hEGF PF12661.7 EMC82044.1 - 0.0023 18.5 0.9 0.0023 18.5 0.9 7.8 7 2 0 7 7 7 1 Human growth factor-like EGF EGF_3 PF12947.7 EMC82044.1 - 0.034 14.3 5.4 0.034 14.3 5.4 5.9 5 2 1 6 6 6 0 EGF domain IL17_R_N PF15037.6 EMC82046.1 - 1.8e-43 149.1 9.4 1e-42 146.5 9.4 1.9 1 1 0 1 1 1 1 Interleukin-17 receptor extracellular region Preseq_ALAS PF09029.10 EMC82046.1 - 0.0024 18.3 0.0 0.0057 17.1 0.0 1.6 1 0 0 1 1 1 1 5-aminolevulinate synthase presequence Innexin PF00876.18 EMC82048.1 - 8.8e-10 38.4 2.3 3.9e-09 36.3 1.9 2.0 1 1 1 2 2 2 1 Innexin DUF2207 PF09972.9 EMC82048.1 - 0.0012 17.8 0.1 0.0017 17.2 0.1 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Ecl1 PF12855.7 EMC82048.1 - 0.092 13.9 0.1 0.092 13.9 0.1 2.4 2 0 0 2 2 2 0 ECL1/2/3 zinc binding proteins Tetraspanin PF00335.20 EMC82049.1 - 0.0011 18.7 4.6 0.0011 18.7 4.6 1.0 1 0 0 1 1 1 1 Tetraspanin family TMEM238 PF15125.6 EMC82049.1 - 0.0077 16.4 2.0 0.0086 16.3 2.0 1.1 1 0 0 1 1 1 1 TMEM238 protein family KCH PF16944.5 EMC82049.1 - 0.64 9.7 4.2 0.61 9.8 4.2 1.0 1 0 0 1 1 1 0 Fungal potassium channel TraB PF01963.17 EMC82050.1 - 1.8e-28 100.2 0.1 2.8e-28 99.6 0.1 1.3 1 0 0 1 1 1 1 TraB family DNA_pol_D_N PF18018.1 EMC82050.1 - 0.024 14.7 2.1 0.32 11.1 1.3 2.2 2 0 0 2 2 2 0 DNA polymerase delta subunit OB-fold domain GCP_C_terminal PF04130.13 EMC82051.1 - 3e-25 89.3 2.6 3.3e-25 89.2 2.6 1.0 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal HTH_37 PF13744.6 EMC82051.1 - 0.17 11.8 0.0 0.27 11.2 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain Hist_deacetyl PF00850.19 EMC82052.1 - 1.2e-53 182.6 0.2 1.4e-53 182.3 0.2 1.0 1 0 0 1 1 1 1 Histone deacetylase domain Cytadhesin_P30 PF07271.11 EMC82053.1 - 4.3e-05 23.2 14.5 0.27 10.8 2.0 3.3 1 1 2 3 3 3 3 Cytadhesin P30/P32 Microvir_H PF04687.12 EMC82053.1 - 0.002 17.5 5.0 15 4.8 0.1 5.4 2 2 2 4 4 4 3 Microvirus H protein (pilot protein) Gly_rich_SFCGS PF14272.6 EMC82053.1 - 0.0044 17.0 2.1 93 3.1 0.0 5.1 3 1 5 8 8 8 0 Glycine-rich SFCGS Fz PF01392.22 EMC82054.1 - 1.6e-27 96.3 3.7 1.6e-27 96.3 3.7 2.1 3 0 0 3 3 3 1 Fz domain Pkinase PF00069.25 EMC82055.1 - 3.6e-64 216.7 0.2 4.7e-64 216.3 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC82055.1 - 2.3e-27 95.9 0.1 3.1e-27 95.5 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EMC82055.1 - 6.8e-05 22.0 1.0 7.8e-05 21.8 0.1 1.4 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EMC82055.1 - 0.00043 20.3 0.0 0.0013 18.8 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EMC82055.1 - 0.0025 17.2 0.0 0.0046 16.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EMC82055.1 - 0.0054 16.1 0.0 0.0079 15.5 0.0 1.4 1 1 0 1 1 1 1 Kinase-like UvrD_C PF13361.6 EMC82055.1 - 0.021 14.2 0.0 0.032 13.6 0.0 1.2 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF3381 PF11861.8 EMC82055.1 - 0.054 13.3 1.6 0.085 12.7 0.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) FTA2 PF13095.6 EMC82055.1 - 0.084 12.5 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Bcl-2 PF00452.19 EMC82056.1 - 2.9e-05 24.7 0.0 7.2e-05 23.4 0.0 1.7 1 1 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family CF222 PF15661.5 EMC82056.1 - 0.023 13.6 0.0 0.028 13.4 0.0 1.2 1 0 0 1 1 1 0 C6orf222, uncharacterised family Ldl_recept_b PF00058.17 EMC82057.1 - 1.2e-156 509.0 44.4 7.7e-14 51.9 0.2 20.4 20 0 0 20 20 20 20 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 EMC82057.1 - 3.1e-40 136.1 66.3 1.9e-11 44.1 8.2 5.8 5 1 0 5 5 5 4 Coagulation Factor Xa inhibitory site Ldl_recept_a PF00057.18 EMC82057.1 - 1.4e-31 108.4 48.5 6.1e-11 42.4 8.3 3.8 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A DUF5050 PF16472.5 EMC82057.1 - 2.5e-19 69.6 0.0 0.00027 20.3 0.0 6.5 4 3 2 7 7 7 5 Domain of unknown function (DUF5050) SGL PF08450.12 EMC82057.1 - 1.1e-16 61.2 19.2 0.065 12.8 0.0 11.8 6 4 4 11 11 11 5 SMP-30/Gluconolactonase/LRE-like region cEGF PF12662.7 EMC82057.1 - 0.0017 18.3 0.6 0.0017 18.3 0.6 5.1 5 0 0 5 5 5 2 Complement Clr-like EGF-like EGF PF00008.27 EMC82057.1 - 0.0097 16.2 4.9 0.0097 16.2 4.9 6.3 6 0 0 6 6 6 4 EGF-like domain NHL PF01436.21 EMC82057.1 - 0.01 15.9 0.1 28 5.0 0.0 5.6 7 0 0 7 7 7 0 NHL repeat Lactonase PF10282.9 EMC82057.1 - 0.16 11.2 0.0 19 4.4 0.0 3.5 4 0 0 4 4 4 0 Lactonase, 7-bladed beta-propeller YoeB_toxin PF06769.14 EMC82057.1 - 0.25 11.4 2.7 43 4.2 0.1 4.2 4 0 0 4 4 4 0 YoeB-like toxin of bacterial type II toxin-antitoxin system MANEC PF07502.14 EMC82058.1 - 1.3e-19 70.2 0.9 2.7e-19 69.2 0.9 1.5 1 0 0 1 1 1 1 MANEC domain DUF5585 PF17823.1 EMC82058.1 - 6.1e-09 35.4 0.3 6.1e-09 35.4 0.3 2.3 2 0 0 2 2 2 1 Family of unknown function (DUF5585) LOH1CR12 PF10158.9 EMC82059.1 - 1.6e-53 180.2 1.1 1.8e-53 180.0 1.1 1.0 1 0 0 1 1 1 1 Tumour suppressor protein DUF1664 PF07889.12 EMC82059.1 - 0.0023 18.0 1.2 0.0031 17.5 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) RE_Bpu10I PF09549.10 EMC82059.1 - 0.0034 17.0 0.3 0.004 16.8 0.3 1.1 1 0 0 1 1 1 1 Bpu10I restriction endonuclease ING PF12998.7 EMC82059.1 - 0.03 14.9 1.5 0.043 14.4 1.3 1.4 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding BLOC1_2 PF10046.9 EMC82059.1 - 0.057 13.7 2.5 0.079 13.3 2.1 1.6 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 POX PF07526.11 EMC82059.1 - 0.46 11.1 4.6 0.73 10.4 4.6 1.4 1 1 0 1 1 1 0 Associated with HOX DSPc PF00782.20 EMC82060.1 - 5.9e-43 145.9 0.0 1.2e-42 144.9 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 EMC82060.1 - 3.8e-13 49.9 0.0 1.4e-12 48.0 0.0 2.0 2 0 0 2 2 2 1 Rhodanese-like domain Y_phosphatase PF00102.27 EMC82060.1 - 0.0004 20.0 0.0 0.00093 18.8 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase zf-RING_14 PF17978.1 EMC82060.1 - 0.01 16.3 0.3 0.18 12.2 0.0 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain bZIP_2 PF07716.15 EMC82061.1 - 1.9e-08 34.3 7.8 2.9e-08 33.7 7.8 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EMC82061.1 - 8e-05 22.7 6.9 0.00014 21.9 6.9 1.5 1 0 0 1 1 1 1 bZIP transcription factor 7tm_1 PF00001.21 EMC82062.1 - 8.1e-44 149.9 18.1 1e-43 149.6 18.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC82062.1 - 5e-08 32.6 20.7 7.2e-08 32.1 20.7 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC82062.1 - 7.2e-05 22.7 14.2 0.0056 16.4 14.2 2.6 1 1 0 1 1 1 1 Olfactory receptor DUF5083 PF16890.5 EMC82062.1 - 0.53 10.0 12.1 0.61 9.8 4.2 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF5083) CDI PF02234.19 EMC82063.1 - 6.9e-17 61.4 1.0 7.5e-17 61.3 1.0 1.0 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor CDI PF02234.19 EMC82064.1 - 2.2e-21 75.8 6.9 4.6e-21 74.7 3.0 2.5 2 0 0 2 2 2 1 Cyclin-dependent kinase inhibitor US6 PF17616.2 EMC82064.1 - 0.25 11.3 1.6 1.5 8.8 1.6 1.9 1 1 0 2 2 2 0 Viral unique short region 6 Ion_trans PF00520.31 EMC82066.1 - 7e-28 97.5 11.2 1.1e-27 96.9 11.2 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 EMC82066.1 - 6.5e-12 45.2 5.2 6.5e-12 45.2 5.2 2.8 3 2 0 3 3 3 1 Ion channel PsbW PF07123.12 EMC82066.1 - 0.086 12.9 0.1 0.19 11.7 0.1 1.6 1 0 0 1 1 1 0 Photosystem II reaction centre W protein (PsbW) CD225 PF04505.12 EMC82066.1 - 0.41 10.8 0.1 0.41 10.8 0.1 3.4 5 0 0 5 5 5 0 Interferon-induced transmembrane protein DUF2798 PF11391.8 EMC82066.1 - 0.77 9.8 6.8 0.41 10.7 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2798) YpmT PF17431.2 EMC82066.1 - 1.1 9.4 4.9 3 8.0 0.1 2.6 2 0 0 2 2 2 0 Uncharacterized YmpT-like MRP-S28 PF10213.9 EMC82067.1 - 3.4e-19 69.5 0.1 6.2e-19 68.7 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein MANEC PF07502.14 EMC82068.1 - 9.9e-07 28.9 3.2 9.9e-07 28.9 3.2 1.9 2 0 0 2 2 2 1 MANEC domain CiPC PF15800.5 EMC82068.1 - 0.44 10.2 18.2 0.65 9.7 18.2 1.2 1 0 0 1 1 1 0 Clock interacting protein circadian Kelch_1 PF01344.25 EMC82069.1 - 1e-28 98.7 5.8 1.7e-09 37.1 0.0 5.3 5 1 0 5 5 5 4 Kelch motif Kelch_6 PF13964.6 EMC82069.1 - 9.9e-25 86.0 3.5 7.5e-08 32.4 0.0 5.8 4 2 1 5 5 5 5 Kelch motif Kelch_3 PF13415.6 EMC82069.1 - 1.6e-11 44.2 3.5 0.00052 20.2 0.0 5.3 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_2 PF07646.15 EMC82069.1 - 2.5e-11 43.1 0.7 0.0089 16.0 0.0 5.0 5 0 0 5 5 5 4 Kelch motif Kelch_5 PF13854.6 EMC82069.1 - 3.6e-11 42.8 1.1 8.4e-05 22.5 0.0 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 EMC82069.1 - 7.2e-05 22.7 5.9 0.58 10.2 0.0 5.5 5 2 0 5 5 5 2 Galactose oxidase, central domain BTB PF00651.31 EMC82069.1 - 0.00072 19.8 0.0 0.017 15.3 0.0 2.4 1 1 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 EMC82069.1 - 0.011 15.8 0.0 0.025 14.7 0.0 1.6 1 0 0 1 1 1 0 BTB And C-terminal Kelch BILBO1_N PF18281.1 EMC82069.1 - 0.29 11.6 0.7 29 5.2 0.0 3.5 4 0 0 4 4 4 0 BILBO1 N-terminal domain Parathyroid PF01279.17 EMC82070.1 - 4.8e-38 130.1 0.6 1.1e-37 128.9 0.6 1.6 1 0 0 1 1 1 1 Parathyroid hormone family RRP14 PF15459.6 EMC82070.1 - 4.4 8.0 12.0 7.9 7.2 12.0 1.4 1 0 0 1 1 1 0 60S ribosome biogenesis protein Rrp14 GAPES4 PF17157.4 EMC82071.1 - 0.0049 17.2 2.6 0.0049 17.2 2.6 1.9 2 0 0 2 2 2 1 Gammaproteobacterial periplasmic sensor domain ERp29 PF07749.12 EMC82071.1 - 0.029 15.2 5.2 0.029 15.2 5.2 4.4 2 1 2 4 4 4 0 Endoplasmic reticulum protein ERp29, C-terminal domain FAM25 PF15825.5 EMC82071.1 - 0.12 12.7 0.4 0.12 12.7 0.4 3.3 2 1 1 3 3 3 0 FAM25 family TPALS PF18178.1 EMC82071.1 - 2.5 7.5 15.7 0.55 9.6 1.0 2.7 2 1 0 2 2 2 0 TIR- and PNP-associating SLOG family Trans_reg_C PF00486.28 EMC82071.1 - 7.5 6.7 9.7 3.9 7.6 0.8 4.4 3 3 2 6 6 6 0 Transcriptional regulatory protein, C terminal zf-H2C2_2 PF13465.6 EMC82072.1 - 2.2e-29 100.6 32.5 2.2e-09 37.3 0.6 5.2 5 0 0 5 5 5 5 Zinc-finger double domain zf-C2H2 PF00096.26 EMC82072.1 - 7.1e-25 86.0 33.9 1.5e-06 28.4 0.4 5.1 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC82072.1 - 1.5e-18 65.9 31.4 8.8e-05 23.0 0.5 5.1 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC82072.1 - 1.1e-13 51.1 10.1 0.0052 17.0 0.0 4.8 4 0 0 4 4 4 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMC82072.1 - 4.7e-10 39.2 26.1 0.021 14.8 2.9 5.4 5 0 0 5 5 5 4 C2H2-type zinc finger zf-met PF12874.7 EMC82072.1 - 3.8e-07 30.3 20.2 0.11 13.0 0.8 4.5 4 0 0 4 4 4 4 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 EMC82072.1 - 5.4e-06 26.4 22.1 0.083 13.0 3.2 3.7 2 1 2 4 4 4 3 Zinc ribbon domain zf-LYAR PF08790.11 EMC82072.1 - 6.1e-05 22.8 20.0 0.49 10.3 0.1 5.3 5 0 0 5 5 5 2 LYAR-type C2HC zinc finger zf-C2H2_8 PF15909.5 EMC82072.1 - 0.00011 22.5 17.3 0.0036 17.6 5.1 3.4 1 1 3 4 4 4 3 C2H2-type zinc ribbon XPA_N PF01286.18 EMC82072.1 - 0.00019 21.4 20.9 0.71 10.0 0.0 5.2 5 0 0 5 5 5 2 XPA protein N-terminal TFIIS_C PF01096.18 EMC82072.1 - 0.00081 19.2 20.8 1.5 8.7 0.3 5.2 5 0 0 5 5 5 2 Transcription factor S-II (TFIIS) zf_UBZ PF18439.1 EMC82072.1 - 0.0071 15.9 17.1 4.2 7.1 0.0 5.3 5 0 0 5 5 5 1 Ubiquitin-Binding Zinc Finger zinc_ribbon_15 PF17032.5 EMC82072.1 - 0.0084 16.8 18.3 0.1 13.4 1.0 3.1 1 1 3 4 4 4 4 zinc-ribbon family DNA_RNApol_7kD PF03604.13 EMC82072.1 - 0.016 14.9 17.4 0.75 9.5 1.0 4.8 5 0 0 5 5 5 0 DNA directed RNA polymerase, 7 kDa subunit zf-C2H2_11 PF16622.5 EMC82072.1 - 0.018 14.8 23.7 2 8.2 0.3 5.2 5 0 0 5 5 5 0 zinc-finger C2H2-type zf-BED PF02892.15 EMC82072.1 - 0.038 14.0 22.5 0.52 10.4 0.6 4.7 1 1 4 5 5 5 0 BED zinc finger C1_4 PF07975.12 EMC82072.1 - 0.039 14.2 22.8 0.084 13.1 3.3 4.0 1 1 4 5 5 5 0 TFIIH C1-like domain DZR PF12773.7 EMC82072.1 - 0.054 13.5 20.1 2.2 8.4 6.8 3.2 1 1 1 2 2 2 0 Double zinc ribbon HypA PF01155.19 EMC82072.1 - 0.054 13.5 17.0 0.16 12.0 1.3 3.3 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA LIM PF00412.22 EMC82072.1 - 0.076 13.2 18.9 0.16 12.2 0.6 3.7 2 2 1 3 3 3 0 LIM domain HNH PF01844.23 EMC82072.1 - 0.13 12.5 20.0 0.19 11.9 0.8 5.0 5 0 0 5 5 5 0 HNH endonuclease zf-C2HE PF16278.5 EMC82072.1 - 0.17 12.3 28.6 0.21 12.1 0.9 5.1 1 1 4 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger zf-trcl PF13451.6 EMC82072.1 - 0.25 11.2 23.6 9.4 6.2 0.3 4.7 4 1 1 5 5 5 0 Probable zinc-ribbon domain CpXC PF14353.6 EMC82072.1 - 0.34 11.0 15.2 3.8 7.6 0.8 4.8 2 1 3 5 5 5 0 CpXC protein zf-AN1 PF01428.16 EMC82072.1 - 0.42 10.8 25.6 8.4 6.7 0.1 5.2 4 1 1 5 5 5 0 AN1-like Zinc finger Evr1_Alr PF04777.13 EMC82072.1 - 0.73 10.3 18.5 4 8.0 0.3 4.7 1 1 3 4 4 4 0 Erv1 / Alr family zf_ZIC PF18366.1 EMC82072.1 - 0.78 9.9 9.1 4.8 7.4 0.3 4.1 2 1 2 4 4 4 0 Zic proteins zinc finger domain Sprouty PF05210.13 EMC82072.1 - 3.2 8.2 14.9 0.81 10.1 7.9 2.4 2 1 1 3 3 3 0 Sprouty protein (Spry) Zn_ribbon_SprT PF17283.2 EMC82072.1 - 4.2 7.4 19.2 6.1 6.8 0.1 4.9 4 1 0 4 4 4 0 SprT-like zinc ribbon domain zinc_ribbon_4 PF13717.6 EMC82072.1 - 4.8 7.2 23.5 25 4.9 6.2 4.7 4 1 0 4 4 4 0 zinc-ribbon domain zinc-ribbons_6 PF07191.12 EMC82072.1 - 5.9 7.0 21.3 6.1 6.9 2.4 4.3 1 1 2 3 3 3 0 zinc-ribbons COX5B PF01215.19 EMC82072.1 - 6.2 6.5 9.6 8.7 6.1 0.4 3.4 1 1 3 4 4 4 0 Cytochrome c oxidase subunit Vb Yippee-Mis18 PF03226.14 EMC82072.1 - 6.2 7.1 15.5 1.2e+02 2.9 0.0 4.1 3 1 0 3 3 3 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf_C2H2_ZHX PF18387.1 EMC82072.1 - 7.9 6.2 19.8 3.4 7.4 0.5 4.5 1 1 4 5 5 5 0 Zinc-fingers and homeoboxes C2H2 finger domain Fer4_17 PF13534.6 EMC82072.1 - 9.3 6.9 19.2 24 5.6 0.2 4.7 3 1 1 4 4 4 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 EMC82072.1 - 9.6 6.5 17.9 11 6.4 1.5 4.9 5 0 0 5 5 5 0 4Fe-4S binding domain DASH_Dad3 PF08656.10 EMC82073.1 - 0.043 13.9 0.0 0.065 13.3 0.0 1.3 1 0 0 1 1 1 0 DASH complex subunit Dad3 Baculo_PEP_C PF04513.12 EMC82073.1 - 0.045 13.8 0.0 0.051 13.6 0.0 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Collagen_mid PF15984.5 EMC82073.1 - 0.13 12.0 7.6 0.11 12.2 3.3 2.0 1 1 0 1 1 1 0 Bacterial collagen, middle region RhoGEF PF00621.20 EMC82074.1 - 2.7e-36 125.5 2.9 6e-36 124.4 2.9 1.6 1 0 0 1 1 1 1 RhoGEF domain SH3_9 PF14604.6 EMC82074.1 - 3.1e-11 42.9 0.0 6.6e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC82074.1 - 1e-10 41.0 0.0 2.1e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC82074.1 - 2.9e-08 33.3 0.0 5e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain ZnuA PF01297.17 EMC82074.1 - 0.19 11.1 0.0 0.52 9.7 0.0 1.7 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic 4F5 PF04419.14 EMC82074.1 - 3.6 8.5 6.1 10 7.1 6.1 1.8 1 0 0 1 1 1 0 4F5 protein family Homeodomain PF00046.29 EMC82075.1 - 4.4e-23 80.9 2.1 1.3e-22 79.4 1.7 1.9 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 EMC82075.1 - 0.0018 18.1 0.1 0.0049 16.8 0.0 1.7 2 0 0 2 2 2 1 Homeobox KN domain DUF1323 PF07037.11 EMC82075.1 - 0.21 12.0 0.6 0.37 11.2 0.6 1.3 1 0 0 1 1 1 0 Putative transcription regulator (DUF1323) Tetraspanin PF00335.20 EMC82076.1 - 4.6e-38 131.2 11.0 6e-38 130.8 11.0 1.2 1 0 0 1 1 1 1 Tetraspanin family DUF2207 PF09972.9 EMC82076.1 - 0.17 10.6 6.1 0.29 9.8 1.4 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF4579 PF15158.6 EMC82076.1 - 0.24 11.1 1.3 0.3 10.8 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4579) C8 PF08742.11 EMC82077.1 - 2.1e-16 60.1 7.4 2.1e-16 60.1 7.4 2.1 2 0 0 2 2 2 1 C8 domain TIL PF01826.17 EMC82077.1 - 1.8e-07 31.3 13.5 1.8e-07 31.3 13.5 2.8 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain VWA PF00092.28 EMC82078.1 - 1e-36 126.8 0.1 2.5e-36 125.5 0.1 1.5 2 0 0 2 2 2 1 von Willebrand factor type A domain VWD PF00094.25 EMC82078.1 - 5.6e-28 98.2 0.9 1.5e-27 96.8 0.9 1.8 1 0 0 1 1 1 1 von Willebrand factor type D domain VWA_2 PF13519.6 EMC82078.1 - 2.3e-11 44.3 0.1 3.8e-11 43.6 0.1 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWC PF00093.18 EMC82078.1 - 1.2e-08 35.1 41.1 6e-06 26.5 13.9 12.1 7 2 4 11 11 11 3 von Willebrand factor type C domain Anoctamin PF04547.12 EMC82079.1 - 8.8e-156 519.2 11.8 1.1e-155 518.9 11.8 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 EMC82079.1 - 5.7e-80 268.3 0.0 5.7e-80 268.3 0.0 1.8 2 0 0 2 2 2 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin NGF PF00243.18 EMC82080.1 - 8.7e-52 174.1 3.7 1.6e-51 173.3 3.7 1.4 1 0 0 1 1 1 1 Nerve growth factor family Spaetzle PF16077.5 EMC82080.1 - 0.0006 20.3 0.5 0.0006 20.3 0.5 1.8 2 0 0 2 2 2 1 Spaetzle ELO PF01151.18 EMC82081.1 - 4.6e-63 213.1 25.7 5.4e-63 212.8 25.7 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Ion_trans PF00520.31 EMC82082.1 - 2.9e-52 177.3 11.1 4.1e-52 176.9 11.1 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 EMC82082.1 - 1.5e-28 99.0 0.3 3.7e-28 97.7 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain Ion_trans_2 PF07885.16 EMC82082.1 - 6.2e-14 51.7 5.2 6.2e-14 51.7 5.2 2.8 3 0 0 3 3 3 1 Ion channel PKD_channel PF08016.12 EMC82082.1 - 0.012 14.4 0.5 0.012 14.4 0.5 1.8 1 1 1 2 2 2 0 Polycystin cation channel Sigma_reg_N PF13800.6 EMC82082.1 - 0.16 12.3 8.1 4.6 7.6 0.1 3.8 3 1 0 3 3 3 0 Sigma factor regulator N-terminal DUF423 PF04241.15 EMC82082.1 - 5 7.4 4.9 1.3 9.3 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF423) FAM75 PF14650.6 EMC82083.1 - 3.4 7.1 10.8 3.8 7.0 10.8 1.0 1 0 0 1 1 1 0 FAM75 family Methyltransf_31 PF13847.6 EMC82084.1 - 2.8e-07 30.5 0.0 4.5e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC82084.1 - 3.4e-07 30.9 0.0 6e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC82084.1 - 1.8e-05 24.6 0.0 2.9e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC82084.1 - 0.00011 22.7 0.0 0.00023 21.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EMC82084.1 - 0.00023 20.7 0.0 0.00043 19.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EMC82084.1 - 0.00028 20.4 0.2 0.00048 19.6 0.0 1.4 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 EMC82084.1 - 0.00039 21.1 0.2 0.0016 19.2 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 EMC82084.1 - 0.00057 19.8 0.0 0.0009 19.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EMC82084.1 - 0.066 12.5 0.1 0.097 11.9 0.1 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PCMT PF01135.19 EMC82084.1 - 0.074 12.8 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GTP_EFTU PF00009.27 EMC82085.1 - 1e-23 83.9 0.0 1.7e-23 83.2 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EMC82085.1 - 6.6e-07 29.6 0.8 2.2e-06 27.9 0.1 2.4 3 0 0 3 3 3 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 EMC82085.1 - 0.00039 20.7 0.3 0.0021 18.3 0.1 2.3 2 1 0 2 2 2 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 EMC82085.1 - 0.0013 18.7 0.1 0.0041 17.2 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 EMC82085.1 - 0.0019 18.0 0.0 3.2 7.5 0.0 3.5 2 1 1 3 3 3 1 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 EMC82085.1 - 0.029 14.3 0.1 4.4 7.2 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase Dynamin_N PF00350.23 EMC82085.1 - 0.11 12.6 0.2 0.69 10.0 0.1 2.2 1 1 1 2 2 2 0 Dynamin family Arf PF00025.21 EMC82085.1 - 0.16 11.4 0.1 15 5.0 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family Sad1_UNC PF07738.13 EMC82086.1 - 1.1e-45 154.9 0.0 1.6e-45 154.3 0.0 1.3 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Sun2_CC2 PF18580.1 EMC82086.1 - 2.9e-24 85.1 5.5 2.9e-24 85.1 5.5 2.9 3 0 0 3 3 3 1 SUN2 coiled coil domain 2 ZapB PF06005.12 EMC82086.1 - 0.012 16.0 1.1 0.012 16.0 1.1 3.5 2 1 1 3 3 3 0 Cell division protein ZapB FAM184 PF15665.5 EMC82086.1 - 0.028 14.2 4.7 0.07 12.9 4.7 1.6 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B Phage_TAC_11 PF11836.8 EMC82086.1 - 0.039 14.1 0.8 0.14 12.3 0.8 1.9 1 0 0 1 1 1 0 Phage tail tube protein, GTA-gp10 DUF1664 PF07889.12 EMC82086.1 - 0.072 13.1 0.6 0.64 10.1 0.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Fez1 PF06818.15 EMC82086.1 - 0.17 12.3 8.4 0.31 11.5 8.4 1.4 1 0 0 1 1 1 0 Fez1 ABC_tran_CTD PF16326.5 EMC82086.1 - 0.19 12.0 16.3 0.62 10.4 0.1 4.3 4 0 0 4 4 4 0 ABC transporter C-terminal domain DUF1640 PF07798.11 EMC82086.1 - 0.2 11.7 8.5 0.24 11.4 3.7 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1640) FlaC_arch PF05377.11 EMC82086.1 - 0.21 12.0 1.3 0.58 10.6 0.1 2.4 3 0 0 3 3 2 0 Flagella accessory protein C (FlaC) bZIP_1 PF00170.21 EMC82086.1 - 0.29 11.3 4.6 1.3 9.1 0.4 2.9 2 1 0 2 2 2 0 bZIP transcription factor DUF4407 PF14362.6 EMC82086.1 - 0.39 10.0 6.8 0.068 12.5 2.0 2.0 1 1 1 2 2 1 0 Domain of unknown function (DUF4407) DUF4618 PF15397.6 EMC82086.1 - 1.1 8.6 6.2 0.16 11.3 1.9 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) DUF4140 PF13600.6 EMC82086.1 - 1.6 9.2 6.6 7.2 7.1 0.8 3.7 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Spc7 PF08317.11 EMC82086.1 - 3.9 6.3 7.4 3.6 6.4 5.9 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein DivIC PF04977.15 EMC82086.1 - 4 7.3 8.9 14 5.5 0.1 4.0 3 1 1 4 4 4 0 Septum formation initiator Atg14 PF10186.9 EMC82086.1 - 6.5 5.7 5.3 13 4.7 4.8 1.5 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fam20C PF06702.12 EMC82087.1 - 7.2e-102 339.8 0.0 9.9e-102 339.4 0.0 1.2 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.6 EMC82087.1 - 0.03 13.2 0.0 0.05 12.5 0.0 1.3 1 0 0 1 1 1 0 FAM198 protein Dynein_light PF01221.18 EMC82088.1 - 5.8e-28 97.0 0.3 7.2e-28 96.7 0.3 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 DUF3109 PF11307.8 EMC82088.1 - 0.017 14.9 0.0 0.018 14.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3109) GARS_A PF01071.19 EMC82088.1 - 0.025 14.3 0.0 0.028 14.2 0.0 1.1 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Pentaxin PF00354.17 EMC82089.1 - 3.7e-09 36.5 0.0 4.7e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.6 EMC82089.1 - 0.00034 20.8 0.0 0.00045 20.4 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily LIAS_N PF16881.5 EMC82089.1 - 0.087 13.3 0.2 0.21 12.0 0.2 1.8 1 1 0 1 1 1 0 N-terminal domain of lipoyl synthase of Radical_SAM family Pox_A_type_inc PF04508.12 EMC82089.1 - 0.11 12.4 0.1 0.31 11.0 0.1 1.8 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat CBX7_C PF17218.3 EMC82090.1 - 1.2e-14 53.7 1.2 2.4e-14 52.7 1.2 1.6 1 0 0 1 1 1 1 CBX family C-terminal motif Chromo PF00385.24 EMC82091.1 - 1.3e-11 44.2 0.7 2.7e-11 43.2 0.7 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain CBX7_C PF17218.3 EMC82091.1 - 5.3e-11 42.0 2.1 1e-10 41.1 2.1 1.5 1 0 0 1 1 1 1 CBX family C-terminal motif PDGF PF00341.17 EMC82092.1 - 2.3e-25 88.7 13.2 3.8e-25 88.0 13.2 1.4 1 0 0 1 1 1 1 PDGF/VEGF domain PDGF_N PF04692.13 EMC82092.1 - 2.1e-12 47.6 2.0 3.1e-12 47.1 0.2 2.2 2 0 0 2 2 2 1 Platelet-derived growth factor, N terminal region Ribosomal_L3 PF00297.22 EMC82093.1 - 5.7e-191 634.3 11.6 6.6e-191 634.1 11.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 RTX PF02382.15 EMC82093.1 - 0.11 12.2 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 N-terminal domain in RTX protein PP2C PF00481.21 EMC82094.1 - 1.1e-39 136.7 0.0 1.6e-39 136.1 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C MARVEL PF01284.23 EMC82094.1 - 9.9e-22 77.5 2.5 1.6e-21 76.8 2.5 1.3 1 0 0 1 1 1 1 Membrane-associating domain Ost5 PF05251.12 EMC82094.1 - 0.12 12.7 0.3 2.5 8.4 0.0 2.4 1 1 1 2 2 2 0 Oligosaccharyltransferase subunit 5 Glyco_transf_17 PF04724.13 EMC82096.1 - 1.8e-26 93.0 7.7 2.3e-23 82.8 0.0 3.3 3 1 0 3 3 3 2 Glycosyltransferase family 17 Mab-21 PF03281.14 EMC82097.1 - 7.7e-17 61.5 0.0 2e-15 56.9 0.0 2.1 1 1 1 2 2 2 2 Mab-21 protein bZIP_1 PF00170.21 EMC82098.1 - 6.1e-16 58.3 14.8 6.1e-16 58.3 14.8 1.8 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EMC82098.1 - 4.4e-07 29.9 12.8 8.6e-07 28.9 12.8 1.5 1 0 0 1 1 1 1 Basic region leucine zipper ZapB PF06005.12 EMC82098.1 - 0.027 14.9 5.0 0.027 14.9 5.0 2.0 1 1 1 2 2 2 0 Cell division protein ZapB DUF3450 PF11932.8 EMC82098.1 - 0.19 11.0 8.8 0.33 10.2 8.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) bZIP_Maf PF03131.17 EMC82098.1 - 0.31 11.6 8.8 0.55 10.8 8.8 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor Laminin_II PF06009.12 EMC82098.1 - 0.37 10.8 6.2 0.62 10.1 6.2 1.2 1 0 0 1 1 1 0 Laminin Domain II Baculo_F PF12259.8 EMC82098.1 - 0.43 9.1 4.5 0.62 8.5 4.5 1.1 1 0 0 1 1 1 0 Baculovirus F protein UPF0242 PF06785.11 EMC82098.1 - 0.43 10.7 7.2 0.67 10.0 7.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus UPF0449 PF15136.6 EMC82098.1 - 0.67 10.5 5.2 1.5 9.3 5.2 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 AAA_13 PF13166.6 EMC82098.1 - 1.1 7.8 10.6 1.4 7.4 10.6 1.1 1 0 0 1 1 1 0 AAA domain DUF724 PF05266.14 EMC82098.1 - 1.7 8.4 11.8 3.3 7.5 11.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF4407 PF14362.6 EMC82098.1 - 2.9 7.2 9.5 4.3 6.6 9.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Atg14 PF10186.9 EMC82098.1 - 5.2 6.1 14.9 3.5 6.6 13.5 1.4 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 AROS PF15684.5 EMC82099.1 - 2.4e-25 89.6 2.7 2.9e-25 89.3 2.7 1.0 1 0 0 1 1 1 1 Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1 SH3_1 PF00018.28 EMC82100.1 - 2.6e-32 110.2 0.2 1.7e-15 56.4 0.0 2.3 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 EMC82100.1 - 5.6e-30 102.9 0.1 8.5e-15 54.4 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH2 PF00017.24 EMC82100.1 - 9.2e-22 76.9 0.7 1.5e-21 76.3 0.7 1.3 1 0 0 1 1 1 1 SH2 domain SH3_2 PF07653.17 EMC82100.1 - 9.8e-21 73.2 0.0 2.4e-09 36.7 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH2_2 PF14633.6 EMC82100.1 - 0.00047 19.6 0.4 0.0013 18.2 0.4 1.6 1 1 0 1 1 1 1 SH2 domain DUF5348 PF17295.2 EMC82100.1 - 0.0011 18.9 0.2 1.2 9.0 0.1 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF5348) SH3_10 PF17902.1 EMC82100.1 - 0.049 13.7 0.0 18 5.5 0.0 2.9 3 0 0 3 3 3 0 SH3 domain FAM83 PF07894.12 EMC82101.1 - 1.4e-107 359.3 0.0 2.2e-107 358.7 0.0 1.3 1 0 0 1 1 1 1 FAM83 A-H PLDc_2 PF13091.6 EMC82101.1 - 2.6e-07 30.6 0.0 4.6e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 PLD-like domain TNRC6-PABC_bdg PF16608.5 EMC82102.1 - 1.2e-96 323.9 26.3 1.2e-96 323.9 26.3 8.5 4 2 6 10 10 10 1 TNRC6-PABC binding domain RRM_occluded PF16842.5 EMC82102.1 - 0.00013 21.8 0.0 0.00032 20.5 0.0 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_1 PF00076.22 EMC82102.1 - 0.00077 19.2 0.0 0.0013 18.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SYF2 PF08231.12 EMC82102.1 - 2.6 8.4 4.0 25 5.2 0.2 2.4 2 0 0 2 2 2 0 SYF2 splicing factor Efg1 PF10153.9 EMC82102.1 - 5.4 7.4 6.3 11 6.4 6.3 1.4 1 0 0 1 1 1 0 rRNA-processing protein Efg1 RabGAP-TBC PF00566.18 EMC82103.1 - 1.6e-50 171.8 1.2 2.2e-50 171.3 1.2 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain RUN PF02759.19 EMC82103.1 - 4.6e-31 107.6 0.1 1.2e-30 106.2 0.1 1.7 1 0 0 1 1 1 1 RUN domain SH3_1 PF00018.28 EMC82103.1 - 5.5e-12 45.1 0.1 1.3e-11 43.9 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC82103.1 - 6.1e-10 38.8 0.0 1.6e-09 37.4 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC82103.1 - 1.3e-09 37.6 0.0 2.8e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain RPEL PF02755.15 EMC82104.1 - 1.8e-17 62.4 3.0 2.8e-08 33.2 0.1 2.9 2 0 0 2 2 2 2 RPEL repeat SAP PF02037.27 EMC82104.1 - 6.6e-12 44.9 0.5 1.5e-11 43.8 0.5 1.6 1 0 0 1 1 1 1 SAP domain DUF722 PF05263.11 EMC82104.1 - 0.051 13.8 0.5 0.1 12.8 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF722) Mito_carr PF00153.27 EMC82105.1 - 2.5e-53 178.0 1.1 2.1e-22 78.8 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein TPR_1 PF00515.28 EMC82106.1 - 2.8e-13 49.1 1.3 2.3e-05 24.0 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EMC82106.1 - 1.4e-11 43.6 8.3 0.0041 17.1 1.3 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 EMC82106.1 - 4.8e-09 35.8 0.1 0.00024 20.7 0.0 3.2 1 1 2 3 3 3 2 TPR repeat TPR_16 PF13432.6 EMC82106.1 - 4.9e-07 30.3 0.1 0.00017 22.1 0.1 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 EMC82106.1 - 2.6e-06 27.4 0.1 0.022 15.1 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 EMC82106.1 - 6.2e-06 26.3 2.8 8.3e-06 25.9 0.6 2.3 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EMC82106.1 - 7.7e-06 26.3 3.9 0.014 16.1 0.0 3.9 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMC82106.1 - 3.8e-05 23.6 4.4 0.02 15.1 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMC82106.1 - 0.0051 17.1 3.8 0.13 12.6 0.1 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMC82106.1 - 0.0096 16.5 0.2 48 4.9 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EMC82106.1 - 0.054 14.0 4.6 0.37 11.3 0.0 3.3 2 1 2 4 4 3 0 Tetratricopeptide repeat DBINO PF13892.6 EMC82106.1 - 0.06 13.7 10.5 0.12 12.7 10.5 1.6 1 0 0 1 1 1 0 DNA-binding domain TPR_7 PF13176.6 EMC82106.1 - 0.24 11.5 3.3 21 5.4 0.1 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat RhoGEF67_u2 PF16614.5 EMC82106.1 - 0.58 10.3 3.3 1.2 9.3 2.1 2.0 2 0 0 2 2 2 0 Unstructured region two on RhoGEF 6 and 7 Rrn6 PF10214.9 EMC82106.1 - 0.77 8.2 8.0 0.22 10.0 4.8 1.4 1 1 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Peptidase_M24 PF00557.24 EMC82108.1 - 6.8e-57 192.5 0.0 9.1e-57 192.1 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EMC82108.1 - 2.9e-37 127.1 0.0 5.3e-37 126.3 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain zf-rbx1 PF12678.7 EMC82109.1 - 6.8e-26 90.3 12.9 8.1e-26 90.1 12.9 1.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EMC82109.1 - 5e-16 58.5 10.6 6e-16 58.3 10.6 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EMC82109.1 - 5.5e-07 29.8 14.9 2.9e-05 24.3 14.9 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC82109.1 - 2.4e-05 24.1 3.2 2.4e-05 24.1 3.2 2.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC82109.1 - 0.0004 20.2 12.2 0.0087 15.9 12.2 2.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMC82109.1 - 0.034 14.0 11.5 0.19 11.6 5.2 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EMC82109.1 - 0.04 13.5 5.3 0.04 13.5 5.3 2.2 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 EMC82109.1 - 0.14 12.4 9.4 0.86 9.8 9.5 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain zf-RING_UBOX PF13445.6 EMC82109.1 - 0.17 11.9 8.2 0.72 9.9 8.2 2.1 1 1 0 1 1 1 0 RING-type zinc-finger zf-RING_11 PF17123.5 EMC82109.1 - 0.18 11.6 16.9 22 4.9 16.9 2.4 1 1 0 1 1 1 0 RING-like zinc finger zf-C3HC4_4 PF15227.6 EMC82109.1 - 3.5 7.9 9.5 0.4 10.9 0.7 2.5 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EMC82109.1 - 4.2 7.4 13.6 42 4.2 13.6 2.5 1 1 1 2 2 2 0 zinc-RING finger domain zf-RING-like PF08746.11 EMC82109.1 - 4.3 7.7 13.0 52 4.3 13.0 2.3 1 1 0 1 1 1 0 RING-like domain 7tm_4 PF13853.6 EMC82112.1 - 2.4e-13 50.5 1.1 2.6e-13 50.3 1.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC82112.1 - 1.1e-12 47.9 2.3 1.3e-12 47.6 2.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) RRM_1 PF00076.22 EMC82114.1 - 3.8e-06 26.6 0.0 4.3e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ig_3 PF13927.6 EMC82115.1 - 2e-29 102.0 0.4 3.5e-16 59.5 0.1 3.1 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 EMC82115.1 - 3.9e-27 94.2 0.0 4.9e-15 55.4 0.0 3.0 3 0 0 3 3 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC82115.1 - 1.1e-16 60.9 0.0 8.5e-08 32.4 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 EMC82115.1 - 1.2e-16 60.7 0.1 3.8e-07 30.2 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain Kazal_2 PF07648.15 EMC82115.1 - 2.1e-08 34.1 6.1 6.4e-08 32.6 6.1 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain V-set PF07686.17 EMC82115.1 - 1.4e-06 28.4 2.4 0.069 13.3 0.0 4.3 3 1 1 4 4 4 2 Immunoglobulin V-set domain EF-hand_1 PF00036.32 EMC82115.1 - 2e-05 23.8 0.4 7e-05 22.1 0.3 2.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 EMC82115.1 - 3.9e-05 23.2 0.8 0.00058 19.6 0.3 2.9 2 0 0 2 2 2 1 EF-hand domain Kazal_1 PF00050.21 EMC82115.1 - 5.4e-05 23.1 7.3 7.3e-05 22.7 6.0 1.9 1 1 0 1 1 1 1 Kazal-type serine protease inhibitor domain EF-hand_7 PF13499.6 EMC82115.1 - 7.9e-05 23.0 3.9 7.9e-05 23.0 3.9 2.1 2 0 0 2 2 2 1 EF-hand domain pair Ig_6 PF18452.1 EMC82115.1 - 0.0028 17.2 0.0 0.6 9.7 0.0 2.9 2 0 0 2 2 2 1 Immunoglobulin domain C1-set PF07654.15 EMC82115.1 - 0.0069 16.7 0.0 0.51 10.7 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin C1-set domain EF-hand_5 PF13202.6 EMC82115.1 - 0.022 14.3 0.2 0.069 12.7 0.2 1.9 1 0 0 1 1 1 0 EF hand SPARC_Ca_bdg PF10591.9 EMC82115.1 - 0.025 14.9 0.5 0.07 13.5 0.5 1.8 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 EMC82115.1 - 0.027 14.3 1.1 0.055 13.3 0.3 1.9 1 1 1 2 2 2 0 EF-hand domain pair C1-set PF07654.15 EMC82116.1 - 4.7e-27 94.2 0.6 5e-27 94.1 0.6 1.0 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.6 EMC82116.1 - 1.4e-06 28.8 0.2 1.7e-06 28.6 0.2 1.1 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC82116.1 - 1.3e-05 25.3 0.2 1.5e-05 25.0 0.2 1.1 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 EMC82116.1 - 0.0004 20.4 0.3 0.00051 20.1 0.3 1.1 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 EMC82116.1 - 0.001 19.4 0.1 0.0012 19.1 0.1 1.1 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC82116.1 - 0.0015 18.5 0.1 0.0019 18.2 0.1 1.1 1 0 0 1 1 1 1 Immunoglobulin I-set domain Cna_B PF05738.13 EMC82116.1 - 0.0074 16.8 0.1 0.0093 16.5 0.1 1.1 1 0 0 1 1 1 1 Cna protein B-type domain SK_channel PF03530.14 EMC82116.1 - 0.034 14.1 0.0 0.043 13.8 0.0 1.2 1 0 0 1 1 1 0 Calcium-activated SK potassium channel Marek_A PF02124.15 EMC82116.1 - 0.037 13.9 0.1 0.044 13.6 0.1 1.0 1 0 0 1 1 1 0 Marek's disease glycoprotein A DUF4448 PF14610.6 EMC82116.1 - 0.067 13.0 0.0 0.073 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Phytochelatin_C PF09328.10 EMC82116.1 - 0.076 12.3 0.0 0.084 12.2 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1984) Collagen PF01391.18 EMC82117.1 - 1.1e-09 37.9 5.1 2.1e-05 24.2 5.1 2.5 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) Ank_2 PF12796.7 EMC82119.1 - 1.3e-100 330.2 35.5 3.1e-14 53.3 0.1 8.0 2 2 7 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC82119.1 - 1.6e-59 197.5 14.0 2.7e-08 34.2 0.0 10.6 4 3 8 12 12 12 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC82119.1 - 1.5e-57 184.7 14.3 0.00017 21.7 0.0 15.9 15 0 0 15 15 15 13 Ankyrin repeat Ank PF00023.30 EMC82119.1 - 4.7e-57 188.1 19.9 1.3e-06 28.6 0.0 14.4 14 0 0 14 14 14 13 Ankyrin repeat Ank_5 PF13857.6 EMC82119.1 - 2e-49 165.0 12.9 7.8e-07 29.2 0.0 12.2 3 3 8 12 12 12 10 Ankyrin repeats (many copies) Ion_trans PF00520.31 EMC82119.1 - 5.7e-16 58.5 18.7 8.8e-16 57.9 18.7 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 EMC82119.1 - 3.1e-05 22.8 19.2 0.0026 16.5 12.1 2.2 1 1 1 2 2 2 2 Polycystin cation channel SchA_CurD PF04486.12 EMC82119.1 - 0.16 12.1 0.0 0.48 10.5 0.0 1.8 1 0 0 1 1 1 0 SchA/CurD like domain BTB_2 PF02214.22 EMC82120.1 - 3.8e-33 113.7 0.0 6.5e-33 113.0 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain DUF4790 PF16037.5 EMC82120.1 - 0.044 14.2 1.7 0.082 13.4 1.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4790) Kv2channel PF03521.14 EMC82121.1 - 1.5e-144 480.8 10.1 2.4e-144 480.0 10.1 1.4 1 0 0 1 1 1 1 Kv2 voltage-gated K+ channel Ion_trans PF00520.31 EMC82121.1 - 7.5e-50 169.4 8.1 9.5e-50 169.1 8.1 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 EMC82121.1 - 5.6e-12 45.5 4.4 5.6e-12 45.5 4.4 1.8 2 0 0 2 2 2 1 Ion channel TRF PF08558.10 EMC82123.1 - 2.5e-25 89.5 1.2 4.1e-25 88.8 1.2 1.2 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.31 EMC82123.1 - 2.4e-09 37.2 0.3 2.4e-09 37.2 0.3 2.5 3 0 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EMC82123.1 - 0.00013 22.2 0.0 0.00036 20.7 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain TPR_7 PF13176.6 EMC82123.1 - 0.031 14.3 0.0 0.092 12.8 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 EMC82123.1 - 0.032 15.1 0.0 0.066 14.1 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TSP_1 PF00090.19 EMC82124.1 - 0.00054 20.1 2.4 0.00054 20.1 2.4 2.5 3 1 0 3 3 3 1 Thrombospondin type 1 domain Ribosomal_L30_N PF08079.12 EMC82125.1 - 6.2e-28 96.9 17.2 1.2e-27 96.0 17.2 1.5 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 EMC82125.1 - 1.4e-25 88.9 1.2 4.1e-25 87.4 1.2 1.8 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e DUF4798 PF16055.5 EMC82125.1 - 9.5 6.5 9.0 16 5.8 9.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4798) adh_short PF00106.25 EMC82127.1 - 2e-16 60.0 0.0 2.4e-16 59.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC82127.1 - 1e-07 31.8 0.0 1.2e-07 31.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Ion_trans_2 PF07885.16 EMC82130.1 - 1.1e-37 127.8 28.7 4.3e-20 71.5 10.0 4.0 3 1 1 4 4 4 3 Ion channel bZIP_Maf PF03131.17 EMC82130.1 - 0.0068 16.9 0.5 0.013 16.0 0.5 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor Wzz PF02706.15 EMC82130.1 - 2.2 8.6 7.2 0.29 11.5 0.6 2.6 2 0 0 2 2 2 0 Chain length determinant protein fn3 PF00041.21 EMC82131.1 - 2.2e-223 723.4 95.0 4.2e-12 46.2 0.6 37.6 36 4 0 36 36 35 32 Fibronectin type III domain Laminin_EGF PF00053.24 EMC82131.1 - 2.4e-77 254.9 190.8 6.9e-09 35.7 16.8 10.9 10 0 0 10 10 10 10 Laminin EGF domain Pur_ac_phosph_N PF16656.5 EMC82131.1 - 8.5e-44 148.1 89.7 0.00037 21.0 0.5 29.2 29 2 0 30 30 28 11 Purple acid Phosphatase, N-terminal domain Laminin_G_2 PF02210.24 EMC82131.1 - 1.2e-39 135.7 0.5 4.3e-19 69.3 0.0 4.2 4 0 0 4 4 4 2 Laminin G domain Laminin_G_1 PF00054.23 EMC82131.1 - 3.3e-35 121.2 0.1 1.4e-16 60.9 0.0 2.6 2 0 0 2 2 2 2 Laminin G domain Laminin_N PF00055.17 EMC82131.1 - 1.5e-32 113.0 0.5 1.9e-29 102.9 0.0 3.1 2 0 0 2 2 2 2 Laminin N-terminal (Domain VI) Laminin_G_3 PF13385.6 EMC82131.1 - 2.1e-19 70.2 0.1 3.5e-13 50.0 0.0 3.6 3 0 0 3 3 3 2 Concanavalin A-like lectin/glucanases superfamily ChitinaseA_N PF08329.10 EMC82131.1 - 4e-17 62.1 24.2 0.8 9.4 0.0 17.2 17 2 1 19 19 19 3 Chitinase A, N-terminal domain DUF2369 PF10179.9 EMC82131.1 - 1.3e-08 35.1 4.1 8.6 6.8 0.0 10.6 11 0 0 11 11 10 1 Uncharacterised conserved protein (DUF2369) fn3_2 PF16893.5 EMC82131.1 - 8.1e-08 32.3 16.4 7.2 6.8 0.0 12.9 15 0 0 15 15 13 2 Fibronectin type III domain SusE PF14292.6 EMC82131.1 - 1.5e-06 28.4 13.5 15 5.9 0.0 10.8 11 0 0 11 11 11 0 SusE outer membrane protein Interfer-bind PF09294.10 EMC82131.1 - 0.00085 19.6 11.9 0.13 12.6 0.0 8.1 9 0 0 9 9 9 1 Interferon-alpha/beta receptor, fibronectin type III PTP_tm PF18861.1 EMC82131.1 - 0.052 13.5 0.0 78 3.2 0.0 5.9 7 0 0 7 7 7 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Arylsulfotran_N PF17425.2 EMC82131.1 - 0.11 12.6 2.9 5.7 7.0 0.0 4.0 3 0 0 3 3 3 0 Arylsulfotransferase Ig-like domain DUF3756 PF12581.8 EMC82131.1 - 0.21 11.5 3.5 6.3 6.8 0.5 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3756) PhoD_N PF16655.5 EMC82131.1 - 2.9 8.5 19.4 14 6.3 0.1 10.2 15 0 0 15 15 14 0 PhoD-like phosphatase, N-terminal domain Hormone_recep PF00104.30 EMC82132.1 - 1.9e-32 112.6 0.4 2.9e-32 112.0 0.4 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 EMC82132.1 - 6.6e-31 106.6 12.3 1.3e-30 105.7 12.3 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) GAT PF03127.14 EMC82132.1 - 0.19 12.0 2.1 0.6 10.5 0.3 2.4 2 0 0 2 2 2 0 GAT domain Ig_3 PF13927.6 EMC82133.1 - 4e-72 238.8 0.0 1.3e-11 44.9 0.0 7.2 7 0 0 7 7 6 6 Immunoglobulin domain I-set PF07679.16 EMC82133.1 - 2.8e-61 203.6 0.3 1.1e-11 44.6 0.0 8.3 7 1 0 7 7 7 6 Immunoglobulin I-set domain ig PF00047.25 EMC82133.1 - 1.8e-45 153.0 0.0 8.8e-10 38.6 0.0 7.3 6 1 0 6 6 6 6 Immunoglobulin domain Ig_2 PF13895.6 EMC82133.1 - 3.9e-44 148.9 0.0 2.2e-07 31.1 0.0 6.4 6 0 0 6 6 6 6 Immunoglobulin domain fn3 PF00041.21 EMC82133.1 - 4.5e-44 148.7 10.1 7e-17 61.6 0.8 4.9 4 0 0 4 4 4 4 Fibronectin type III domain V-set PF07686.17 EMC82133.1 - 8.4e-25 87.1 12.6 0.0094 16.1 0.1 11.0 8 5 2 10 10 9 5 Immunoglobulin V-set domain Ig_5 PF16681.5 EMC82133.1 - 5.1e-11 42.8 0.0 0.24 11.8 0.0 6.6 6 0 0 6 6 6 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 EMC82133.1 - 4.3e-10 39.0 0.3 0.56 9.8 0.0 6.0 6 0 0 6 6 6 3 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 EMC82133.1 - 2e-08 34.7 6.3 2.7e-05 24.6 0.8 3.5 3 1 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Izumo-Ig PF16706.5 EMC82133.1 - 6.8e-08 32.5 0.3 2.5 8.2 0.0 6.4 7 0 0 7 7 7 1 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 EMC82133.1 - 1.4e-07 31.6 0.0 1.1 9.6 0.0 5.1 5 0 0 5 5 5 2 T-cell surface glycoprotein CD3 delta chain Adeno_E3_CR1 PF02440.15 EMC82133.1 - 2.9e-05 23.8 5.2 1.6 8.5 0.0 6.2 6 1 0 6 6 6 1 Adenovirus E3 region protein CR1 Interfer-bind PF09294.10 EMC82133.1 - 4.9e-05 23.6 0.0 0.011 16.1 0.1 3.3 3 0 0 3 3 3 1 Interferon-alpha/beta receptor, fibronectin type III C2-set_2 PF08205.12 EMC82133.1 - 0.00048 20.1 0.0 2.8 8.1 0.0 3.4 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_C17orf99 PF17736.1 EMC82133.1 - 0.00077 19.5 0.0 5 7.2 0.0 5.1 5 0 0 5 5 5 1 C17orf99 Ig domain Tissue_fac PF01108.17 EMC82133.1 - 0.00078 19.3 0.6 0.42 10.5 0.0 4.3 3 1 1 4 4 4 1 Tissue factor CBM_35 PF16990.5 EMC82133.1 - 0.0069 16.6 0.1 0.1 12.9 0.0 3.0 3 0 0 3 3 2 1 Carbohydrate binding module (family 35) DUF4998 PF16389.5 EMC82133.1 - 0.0079 15.8 0.3 0.022 14.3 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function Big_3_4 PF13754.6 EMC82133.1 - 0.047 13.4 0.0 0.2 11.4 0.0 2.2 2 0 0 2 2 1 0 Domain of unknown function DUF2369 PF10179.9 EMC82133.1 - 0.11 12.9 0.1 3.2 8.2 0.0 2.7 1 1 1 2 2 2 0 Uncharacterised conserved protein (DUF2369) PKD PF00801.20 EMC82133.1 - 1.3 8.9 3.5 12 5.9 0.1 3.9 4 0 0 4 4 4 0 PKD domain PDZ PF00595.24 EMC82134.1 - 1.7e-20 73.1 0.2 2e-15 56.9 0.0 2.7 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 EMC82134.1 - 1.2e-15 57.1 1.5 3.4e-13 49.2 0.3 2.6 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 EMC82134.1 - 2.8e-07 30.8 0.1 1.1e-06 28.9 0.0 2.0 2 0 0 2 2 2 1 PDZ domain Tricorn_PDZ PF14685.6 EMC82134.1 - 0.019 14.9 0.0 0.047 13.7 0.0 1.6 1 0 0 1 1 1 0 Tricorn protease PDZ domain Glyco_transf_8 PF01501.20 EMC82135.1 - 1.9e-08 34.2 0.7 3.4e-08 33.4 0.7 1.4 1 1 0 1 1 1 1 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 EMC82135.1 - 0.0024 17.3 0.1 0.0039 16.7 0.1 1.4 1 1 0 1 1 1 1 Glucosyltransferase 24 RRM_1 PF00076.22 EMC82136.1 - 3.1e-22 78.2 0.2 5e-22 77.5 0.2 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMC82136.1 - 6.8e-09 35.4 0.0 1.2e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 EMC82136.1 - 3.2e-05 23.8 2.0 5.6e-05 23.0 2.0 1.4 1 0 0 1 1 1 1 Zinc knuckle SET_assoc PF11767.8 EMC82136.1 - 0.01 15.5 0.0 0.026 14.2 0.0 1.6 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated zf-CCHC_3 PF13917.6 EMC82136.1 - 0.014 15.3 0.9 0.028 14.4 0.9 1.5 1 0 0 1 1 1 0 Zinc knuckle BRAP2 PF07576.12 EMC82136.1 - 0.015 15.5 0.0 0.026 14.7 0.0 1.3 1 0 0 1 1 1 0 BRCA1-associated protein 2 RRM_7 PF16367.5 EMC82136.1 - 0.019 15.1 0.0 0.051 13.7 0.0 1.7 1 1 0 1 1 1 0 RNA recognition motif RRM_occluded PF16842.5 EMC82136.1 - 0.025 14.5 0.0 0.048 13.5 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif Limkain-b1 PF11608.8 EMC82136.1 - 0.036 14.1 0.3 0.16 12.0 0.3 2.0 1 1 0 1 1 1 0 Limkain b1 Lge1 PF11488.8 EMC82137.1 - 2.9e-23 81.8 0.3 7.2e-23 80.6 0.3 1.7 1 0 0 1 1 1 1 Transcriptional regulatory protein LGE1 DUF3614 PF12267.8 EMC82137.1 - 0.29 11.6 6.4 0.47 10.9 6.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3614) PET PF06297.14 EMC82138.1 - 5.4e-39 132.4 1.1 1.6e-38 130.9 1.1 1.9 1 0 0 1 1 1 1 PET Domain LIM PF00412.22 EMC82138.1 - 3.5e-25 88.0 40.3 2e-09 37.5 3.3 3.7 3 0 0 3 3 3 3 LIM domain Vasculin PF15337.6 EMC82138.1 - 0.0026 18.6 0.8 0.015 16.2 0.0 2.6 2 0 0 2 2 2 1 Vascular protein family Vasculin-like 1 TruD PF01142.18 EMC82139.1 - 8.6e-67 225.8 0.0 1.1e-66 225.4 0.0 1.1 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) R3H PF01424.22 EMC82139.1 - 0.0024 17.8 0.0 0.017 15.1 0.1 2.4 2 0 0 2 2 2 1 R3H domain Yqai PF09466.10 EMC82139.1 - 0.08 13.3 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 Hypothetical protein Yqai TMEM117 PF15113.6 EMC82140.1 - 7.2e-229 759.7 27.0 8.3e-229 759.4 27.0 1.0 1 0 0 1 1 1 1 TMEM117 protein family 7tm_1 PF00001.21 EMC82141.1 - 1.5e-30 106.4 23.3 1.5e-30 106.4 23.3 1.4 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) EGF_CA PF07645.15 EMC82142.1 - 6.2e-29 99.9 65.3 1.7e-11 44.1 6.9 10.9 9 2 1 10 10 8 5 Calcium-binding EGF domain VWC PF00093.18 EMC82142.1 - 4e-18 65.5 64.8 2.8e-10 40.3 15.8 10.3 6 1 1 7 7 5 4 von Willebrand factor type C domain EGF_3 PF12947.7 EMC82142.1 - 9.6e-14 51.3 38.6 1.3e-08 34.9 14.1 10.7 10 2 1 11 11 9 5 EGF domain cEGF PF12662.7 EMC82142.1 - 9.1e-09 35.1 11.9 1.1e-07 31.7 3.3 10.8 11 0 0 11 11 11 5 Complement Clr-like EGF-like Laminin_G_2 PF02210.24 EMC82142.1 - 2.1e-07 31.5 0.1 3.8e-07 30.7 0.1 1.3 1 0 0 1 1 1 1 Laminin G domain EGF PF00008.27 EMC82142.1 - 2.4e-06 27.7 21.0 6.2e-05 23.2 8.4 11.9 13 1 1 14 14 8 5 EGF-like domain hEGF PF12661.7 EMC82142.1 - 4.5e-05 23.9 29.9 0.0018 18.9 5.9 12.4 12 0 0 12 12 9 6 Human growth factor-like EGF TILa PF12714.7 EMC82142.1 - 0.00015 21.6 25.8 0.00069 19.5 8.7 11.5 8 4 2 11 11 8 4 TILa domain EGF_MSP1_1 PF12946.7 EMC82142.1 - 0.00015 21.7 8.8 0.00015 21.7 8.8 9.2 9 0 0 9 9 9 3 MSP1 EGF domain 1 Laminin_G_3 PF13385.6 EMC82142.1 - 0.00019 21.6 0.0 0.00034 20.8 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_1 PF00054.23 EMC82142.1 - 0.0003 21.0 0.0 0.00075 19.7 0.0 1.7 1 1 0 1 1 1 1 Laminin G domain FXa_inhibition PF14670.6 EMC82142.1 - 0.017 15.4 6.4 0.017 15.4 6.4 10.9 8 2 3 11 11 8 0 Coagulation Factor Xa inhibitory site Hormone_1 PF00103.20 EMC82143.1 - 1.1e-26 93.9 6.7 8.1e-14 51.9 0.3 2.4 1 1 1 2 2 2 2 Somatotropin hormone family Alpha-2-MRAP_C PF06401.11 EMC82143.1 - 0.0012 18.9 3.8 0.0015 18.5 2.9 1.6 2 0 0 2 2 2 1 Alpha-2-macroglobulin RAP, C-terminal domain Homeodomain PF00046.29 EMC82144.1 - 9.2e-21 73.5 5.5 1.9e-20 72.5 5.5 1.5 1 0 0 1 1 1 1 Homeodomain DUF2986 PF11661.8 EMC82144.1 - 0.0036 17.8 1.8 0.0076 16.7 0.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2986) Homeobox_KN PF05920.11 EMC82144.1 - 0.036 14.0 0.3 0.036 14.0 0.3 2.0 3 0 0 3 3 3 0 Homeobox KN domain Anoctamin PF04547.12 EMC82145.1 - 1.1e-154 515.6 20.6 1.4e-154 515.3 20.6 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 EMC82145.1 - 3.6e-71 239.5 2.5 6.8e-71 238.6 2.5 1.5 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin DUF2207 PF09972.9 EMC82145.1 - 0.073 11.8 8.4 0.31 9.8 0.1 2.7 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) Ctr PF04145.15 EMC82145.1 - 0.16 12.6 5.0 9.6 6.8 0.1 3.6 4 0 0 4 4 4 0 Ctr copper transporter family SPT6_acidic PF14632.6 EMC82145.1 - 0.8 10.3 5.6 10 6.8 0.1 2.3 2 0 0 2 2 2 0 Acidic N-terminal SPT6 Aa_trans PF01490.18 EMC82147.1 - 5.2e-78 262.6 39.6 6e-78 262.4 39.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein UPF0016 PF01169.19 EMC82147.1 - 4 7.8 14.3 3.7 8.0 0.2 3.6 3 1 0 3 3 3 0 Uncharacterized protein family UPF0016 Aa_trans PF01490.18 EMC82149.1 - 2.5e-72 243.8 34.3 7.3e-46 156.7 13.1 2.0 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein ECSCR PF15820.5 EMC82149.1 - 0.24 11.2 1.1 0.68 9.8 0.1 2.4 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator LRR_8 PF13855.6 EMC82151.1 - 7e-25 86.6 11.4 7e-14 51.3 5.7 4.1 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 EMC82151.1 - 1.8e-12 47.2 18.6 8.2e-07 29.3 2.3 4.6 1 1 6 7 7 7 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC82151.1 - 3.1e-07 30.0 4.3 8.7e-06 25.3 0.5 1.8 1 1 1 2 2 2 2 Leucine-rich repeat LRR_5 PF13306.6 EMC82151.1 - 3.8e-07 30.1 0.8 8.8e-07 28.9 0.8 1.6 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EMC82151.1 - 1.1e-06 28.4 19.0 0.069 13.7 0.3 7.5 7 1 0 7 7 7 2 Leucine Rich Repeat ig PF00047.25 EMC82151.1 - 4.5e-06 26.7 0.0 1.1e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC82151.1 - 6.1e-06 26.7 0.0 1.7e-05 25.3 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC82151.1 - 0.00021 21.3 0.0 0.00044 20.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 EMC82151.1 - 0.00032 20.8 0.0 0.00082 19.5 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin V-set domain LRRNT PF01462.18 EMC82151.1 - 0.0022 17.6 2.3 0.0022 17.6 2.3 3.2 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 EMC82151.1 - 0.0023 17.8 13.9 2.3 8.5 0.2 6.1 6 0 0 6 6 6 2 Leucine Rich repeat Herpes_gE PF02480.16 EMC82151.1 - 0.018 13.8 0.0 1.5 7.4 0.0 2.1 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein E Ig_2 PF13895.6 EMC82151.1 - 0.025 14.9 0.0 0.057 13.8 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain TPR_1 PF00515.28 EMC82152.1 - 5.5e-36 120.9 26.0 4.2e-06 26.4 0.3 7.0 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 EMC82152.1 - 3.4e-28 95.4 25.9 7.6e-05 22.5 0.1 6.7 6 0 0 6 6 6 6 Tetratricopeptide repeat RPAP3_C PF13877.6 EMC82152.1 - 5.5e-26 90.9 0.5 2.3e-25 89.0 0.5 2.1 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 TPR_8 PF13181.6 EMC82152.1 - 3.8e-21 73.5 19.4 0.0022 18.0 0.4 7.3 7 0 0 7 7 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 EMC82152.1 - 1.3e-19 69.5 18.8 8.7e-06 25.3 0.0 6.0 3 2 3 6 6 6 4 TPR repeat TPR_7 PF13176.6 EMC82152.1 - 3.3e-15 54.9 9.9 9.2e-05 22.2 0.0 5.9 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_9 PF13371.6 EMC82152.1 - 6.6e-12 45.4 0.6 0.00013 22.1 0.4 4.4 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 EMC82152.1 - 8.3e-12 44.9 1.9 0.031 15.1 0.0 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 EMC82152.1 - 2e-11 44.3 8.0 0.076 13.7 0.2 4.8 2 2 1 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EMC82152.1 - 1.8e-10 41.0 15.9 0.075 13.3 2.5 5.8 4 2 1 5 5 5 4 Tetratricopeptide repeat TPR_19 PF14559.6 EMC82152.1 - 2e-08 34.6 11.9 0.011 16.3 1.4 4.6 3 1 0 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 EMC82152.1 - 0.00012 22.5 11.7 4.4 8.1 0.0 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 EMC82152.1 - 0.0012 18.6 13.8 8.3 6.4 0.5 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_17 PF13431.6 EMC82152.1 - 0.0025 18.1 19.6 0.23 11.9 0.3 6.9 7 0 0 7 7 7 1 Tetratricopeptide repeat MIT PF04212.18 EMC82152.1 - 0.0032 17.5 10.8 2 8.5 0.2 5.1 4 0 0 4 4 4 1 MIT (microtubule interacting and transport) domain NRBF2_MIT PF17169.4 EMC82152.1 - 0.018 15.3 2.3 9.8 6.5 0.2 3.6 2 1 1 3 3 3 0 MIT domain of nuclear receptor-binding factor 2 Fis1_TPR_C PF14853.6 EMC82152.1 - 0.018 15.1 20.8 0.079 13.0 0.0 5.8 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat PPR PF01535.20 EMC82152.1 - 0.023 14.9 3.3 11 6.6 0.1 4.5 5 0 0 5 5 4 0 PPR repeat Reprolysin_5 PF13688.6 EMC82152.1 - 0.12 12.5 0.1 0.8 9.8 0.0 2.1 2 0 0 2 2 2 0 Metallo-peptidase family M12 ANAPC3 PF12895.7 EMC82152.1 - 0.16 12.2 7.8 0.34 11.2 0.8 3.4 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.9 EMC82152.1 - 0.22 11.2 0.0 0.22 11.2 0.0 4.0 3 1 0 3 3 3 0 26S proteasome subunit RPN7 Ldt_C PF17969.1 EMC82152.1 - 0.25 12.1 2.3 35 5.2 0.9 3.1 2 0 0 2 2 2 0 L,D-transpeptidase C-terminal domain PPR_2 PF13041.6 EMC82152.1 - 1.7 8.9 4.4 32 4.8 0.1 3.4 4 0 0 4 4 2 0 PPR repeat family Peptidase_M76 PF09768.9 EMC82153.1 - 1.6e-57 194.0 7.7 1.9e-57 193.8 7.7 1.1 1 0 0 1 1 1 1 Peptidase M76 family HypD PF01924.16 EMC82153.1 - 0.011 14.8 0.0 0.017 14.2 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase formation hypA family SprT-like PF10263.9 EMC82153.1 - 0.032 14.1 0.4 0.053 13.4 0.4 1.4 1 0 0 1 1 1 0 SprT-like family Peptidase_M90 PF06167.12 EMC82153.1 - 0.052 13.2 0.1 0.082 12.5 0.1 1.3 1 0 0 1 1 1 0 Glucose-regulated metallo-peptidase M90 Ribosomal_60s PF00428.19 EMC82153.1 - 1.3 9.7 8.7 0.21 12.2 5.1 1.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein ECH_1 PF00378.20 EMC82154.1 - 7e-54 182.8 0.0 8.4e-54 182.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EMC82154.1 - 5.8e-35 121.4 0.0 4.5e-32 111.9 0.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase SARG PF15385.6 EMC82155.1 - 1.1e-15 57.9 34.1 4.6e-09 36.1 0.2 3.9 1 1 1 3 3 3 3 Specifically androgen-regulated gene protein DUF3306 PF11748.8 EMC82155.1 - 1.8 9.5 4.5 2.6 9.0 0.1 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3306) MIF4G PF02854.19 EMC82156.1 - 2.4e-75 252.8 26.6 2.9e-43 148.0 0.0 3.9 4 0 0 4 4 4 3 MIF4G domain Upf2 PF04050.14 EMC82156.1 - 1e-33 117.0 3.7 1e-33 117.0 3.7 5.8 3 3 2 5 5 5 1 Up-frameshift suppressor 2 Transket_pyr PF02779.24 EMC82157.1 - 1.8e-62 210.2 0.0 3.1e-62 209.4 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 EMC82157.1 - 6.3e-47 159.1 0.0 1e-46 158.4 0.0 1.3 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal E1_dh PF00676.20 EMC82157.1 - 3.1e-45 154.4 0.0 6.6e-45 153.3 0.0 1.5 1 1 0 1 1 1 1 Dehydrogenase E1 component SecY PF00344.20 EMC82158.1 - 3.9e-75 253.0 11.9 5.3e-75 252.5 11.9 1.2 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 EMC82158.1 - 7.5e-19 67.3 0.2 2.4e-18 65.7 0.2 2.0 1 0 0 1 1 1 1 Plug domain of Sec61p YlaH PF14036.6 EMC82158.1 - 0.1 13.0 2.7 6.3 7.2 0.2 3.3 2 0 0 2 2 2 0 YlaH-like protein DUF2975 PF11188.8 EMC82158.1 - 4.4 7.2 9.0 0.93 9.4 0.9 3.7 2 1 2 4 4 4 0 Protein of unknown function (DUF2975) NUDIX PF00293.28 EMC82159.1 - 1.2e-15 57.7 0.4 4.8e-15 55.8 0.0 1.9 2 0 0 2 2 2 1 NUDIX domain D123 PF07065.14 EMC82160.1 - 1.7e-105 352.6 0.1 1.9e-105 352.4 0.1 1.0 1 0 0 1 1 1 1 D123 R2K_2 PF18299.1 EMC82160.1 - 0.042 13.7 0.0 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 ATPgrasp_YheCD PF14398.6 EMC82160.1 - 0.16 11.2 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 YheC/D like ATP-grasp Pkinase PF00069.25 EMC82161.1 - 3.1e-56 190.7 0.0 3.9e-56 190.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC82161.1 - 1.8e-21 76.6 0.0 2.4e-21 76.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC82161.1 - 9.4e-09 35.0 0.0 1.2e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMC82161.1 - 0.00017 20.5 0.0 0.00032 19.6 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EMC82161.1 - 0.00023 20.6 0.0 0.0005 19.5 0.0 1.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 EMC82161.1 - 0.1 11.6 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase APH PF01636.23 EMC82161.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Hypoth_Ymh PF09509.10 EMC82161.1 - 0.14 12.1 0.1 0.62 10.0 0.0 2.1 3 0 0 3 3 3 0 Protein of unknown function (Hypoth_ymh) YscO PF07321.12 EMC82163.1 - 1.8e-06 28.0 8.2 2.8e-06 27.4 8.2 1.2 1 0 0 1 1 1 1 Type III secretion protein YscO ATG16 PF08614.11 EMC82163.1 - 9.2e-05 22.8 5.0 9.9e-05 22.6 5.0 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) bZIP_1 PF00170.21 EMC82163.1 - 0.00055 20.0 3.7 0.00055 20.0 3.7 1.9 1 1 1 2 2 2 1 bZIP transcription factor DUF812 PF05667.11 EMC82163.1 - 0.00071 18.6 5.4 0.00093 18.2 5.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) DUF1664 PF07889.12 EMC82163.1 - 0.00098 19.2 2.4 0.0014 18.7 2.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) KLRAQ PF10205.9 EMC82163.1 - 0.0011 19.2 8.7 0.0017 18.6 8.7 1.2 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein BLOC1_2 PF10046.9 EMC82163.1 - 0.0014 18.9 1.6 0.0023 18.2 1.6 1.4 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fib_alpha PF08702.10 EMC82163.1 - 0.0015 18.7 3.6 0.0022 18.2 3.6 1.2 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family Laminin_II PF06009.12 EMC82163.1 - 0.0018 18.3 3.2 0.0025 17.9 3.2 1.1 1 0 0 1 1 1 1 Laminin Domain II DUF3450 PF11932.8 EMC82163.1 - 0.0019 17.5 3.0 0.0023 17.3 3.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) Tropomyosin_1 PF12718.7 EMC82163.1 - 0.0041 17.3 9.1 0.0055 16.9 9.1 1.1 1 0 0 1 1 1 1 Tropomyosin like FlaC_arch PF05377.11 EMC82163.1 - 0.0044 17.4 2.7 0.019 15.4 3.0 1.9 1 1 1 2 2 2 1 Flagella accessory protein C (FlaC) TMCO5 PF14992.6 EMC82163.1 - 0.0047 16.5 4.2 0.0057 16.3 4.2 1.1 1 0 0 1 1 1 1 TMCO5 family DUF489 PF04356.12 EMC82163.1 - 0.0059 16.6 1.4 0.0074 16.3 1.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF489) Uso1_p115_C PF04871.13 EMC82163.1 - 0.0079 16.6 4.6 0.012 15.9 4.6 1.4 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, C terminal region Occludin_ELL PF07303.13 EMC82163.1 - 0.0081 16.9 5.1 0.013 16.2 5.1 1.3 1 0 0 1 1 1 1 Occludin homology domain ZapB PF06005.12 EMC82163.1 - 0.0082 16.6 6.9 0.015 15.8 6.9 1.4 1 0 0 1 1 1 1 Cell division protein ZapB Ax_dynein_light PF10211.9 EMC82163.1 - 0.0084 16.1 9.2 0.011 15.7 9.2 1.1 1 0 0 1 1 1 1 Axonemal dynein light chain Herpes_UL6 PF01763.16 EMC82163.1 - 0.0092 14.5 2.5 0.0097 14.5 2.5 1.1 1 0 0 1 1 1 1 Herpesvirus UL6 like GrpE PF01025.19 EMC82163.1 - 0.01 15.5 3.3 0.013 15.1 3.3 1.2 1 0 0 1 1 1 0 GrpE HemX PF04375.14 EMC82163.1 - 0.011 15.0 3.4 0.014 14.7 3.4 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase TMF_DNA_bd PF12329.8 EMC82163.1 - 0.015 15.3 8.2 0.027 14.4 8.2 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding TMPIT PF07851.13 EMC82163.1 - 0.021 14.1 2.2 0.022 14.0 2.2 1.2 1 0 0 1 1 1 0 TMPIT-like protein Prominin PF05478.11 EMC82163.1 - 0.023 12.7 1.4 0.024 12.6 1.4 1.1 1 0 0 1 1 1 0 Prominin Atg14 PF10186.9 EMC82163.1 - 0.031 13.4 5.9 0.033 13.3 5.9 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 LMBR1 PF04791.16 EMC82163.1 - 0.035 13.0 0.4 0.032 13.1 0.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF745 PF05335.13 EMC82163.1 - 0.036 13.8 3.2 0.049 13.3 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DUF16 PF01519.16 EMC82163.1 - 0.039 14.4 3.3 0.048 14.2 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF16 Rho_Binding PF08912.11 EMC82163.1 - 0.04 14.7 5.8 0.04 14.7 5.8 1.6 1 1 0 1 1 1 0 Rho Binding DUF3552 PF12072.8 EMC82163.1 - 0.042 13.3 8.8 0.052 13.0 8.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) PRKCSH-like PF12999.7 EMC82163.1 - 0.043 13.6 1.3 0.053 13.3 1.3 1.1 1 0 0 1 1 1 0 Glucosidase II beta subunit-like NPV_P10 PF05531.12 EMC82163.1 - 0.049 14.1 2.2 1.6 9.2 0.1 2.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein EMP24_GP25L PF01105.24 EMC82163.1 - 0.051 13.5 4.0 0.062 13.2 4.0 1.1 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD UPF0242 PF06785.11 EMC82163.1 - 0.054 13.6 4.4 0.068 13.3 4.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus GIT_CC PF16559.5 EMC82163.1 - 0.059 13.2 8.8 0.36 10.7 2.1 2.5 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DegS PF05384.11 EMC82163.1 - 0.072 12.6 7.9 0.064 12.7 5.6 1.4 1 1 1 2 2 2 0 Sensor protein DegS DivIC PF04977.15 EMC82163.1 - 0.076 12.8 7.9 0.12 12.1 7.7 1.5 1 1 0 1 1 1 0 Septum formation initiator P4Ha_N PF08336.11 EMC82163.1 - 0.094 12.7 3.6 0.15 12.1 3.6 1.4 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region SlyX PF04102.12 EMC82163.1 - 0.11 13.1 5.3 0.28 11.8 5.3 1.7 1 1 0 1 1 1 0 SlyX USP8_interact PF08941.10 EMC82163.1 - 0.12 12.2 2.7 0.17 11.7 2.7 1.3 1 0 0 1 1 1 0 USP8 interacting DUF4988 PF16378.5 EMC82163.1 - 0.12 12.0 1.1 0.18 11.4 1.1 1.2 1 0 0 1 1 1 0 Domain of unknown function DASH_Dam1 PF08653.10 EMC82163.1 - 0.13 12.1 1.0 5.1 7.0 0.1 2.4 1 1 1 2 2 2 0 DASH complex subunit Dam1 DUF773 PF05600.12 EMC82163.1 - 0.13 11.0 9.1 0.17 10.6 9.1 1.1 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 Exonuc_VII_L PF02601.15 EMC82163.1 - 0.13 11.8 5.0 0.14 11.7 5.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit ADIP PF11559.8 EMC82163.1 - 0.15 12.2 11.2 0.2 11.7 11.2 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding YabA PF06156.13 EMC82163.1 - 0.15 12.7 6.0 0.25 12.0 6.0 1.4 1 0 0 1 1 1 0 Initiation control protein YabA XhlA PF10779.9 EMC82163.1 - 0.15 12.3 4.4 0.24 11.7 3.8 1.5 1 1 0 1 1 1 0 Haemolysin XhlA DUF3251 PF11622.8 EMC82163.1 - 0.29 10.8 3.0 0.34 10.5 2.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3251) TFR_dimer PF04253.15 EMC82163.1 - 0.63 10.1 4.1 2.3 8.3 3.3 1.9 1 1 1 2 2 2 0 Transferrin receptor-like dimerisation domain DUF2802 PF10975.8 EMC82163.1 - 0.65 10.2 3.9 2.6 8.2 3.8 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2802) DUF4446 PF14584.6 EMC82163.1 - 0.7 9.9 5.8 1.4 8.9 5.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4446) CC2-LZ PF16516.5 EMC82164.1 - 9.2e-30 103.0 16.3 9.2e-30 103.0 16.3 6.2 3 2 0 4 4 4 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator NEMO PF11577.8 EMC82164.1 - 1.2e-28 98.9 12.6 1.2e-28 98.9 12.6 6.6 7 1 0 7 7 7 2 NF-kappa-B essential modulator NEMO zf_C2H2_10 PF18414.1 EMC82164.1 - 1.7e-15 56.2 5.3 3.7e-15 55.1 5.3 1.5 1 0 0 1 1 1 1 C2H2 type zinc-finger MLD PF11647.8 EMC82164.1 - 0.025 14.9 5.0 2.6 8.4 0.1 3.6 2 1 1 3 3 3 0 Membrane Localization Domain Mcm10 PF09332.11 EMC82165.1 - 1.8e-147 491.4 9.6 1.8e-147 491.4 9.6 2.6 3 0 0 3 3 3 1 Mcm10 replication factor zf-primase PF09329.11 EMC82165.1 - 8.8e-18 63.8 2.0 2.6e-17 62.4 2.0 1.9 1 0 0 1 1 1 1 Primase zinc finger FliD_N PF02465.18 EMC82165.1 - 3.2 8.5 8.5 1.1 10.0 1.0 3.3 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus Allexi_40kDa PF05549.11 EMC82165.1 - 8.2 5.8 7.8 1.6 8.2 2.1 2.3 2 0 0 2 2 2 0 Allexivirus 40kDa protein PhyH PF05721.13 EMC82166.1 - 2.2e-42 145.7 0.0 2.7e-42 145.4 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) AIRS_C PF02769.22 EMC82168.1 - 1.4e-30 106.5 0.1 2.1e-30 105.9 0.1 1.3 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 EMC82168.1 - 4.7e-11 43.2 0.2 1.2e-10 41.9 0.2 1.6 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain BEN PF10523.9 EMC82169.1 - 7.5e-18 64.5 0.1 2.2e-17 63.1 0.1 1.8 1 0 0 1 1 1 1 BEN domain Prp18 PF02840.15 EMC82170.1 - 1.2e-62 210.1 0.1 1.9e-62 209.5 0.1 1.3 1 0 0 1 1 1 1 Prp18 domain PRP4 PF08799.11 EMC82170.1 - 1e-13 50.5 3.5 1e-13 50.5 3.5 2.0 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like Phage_int_SAM_4 PF13495.6 EMC82170.1 - 0.084 13.4 0.2 17 6.0 0.0 2.7 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain DUF3338 PF11819.8 EMC82171.1 - 2.4e-59 199.2 6.0 2.4e-59 199.2 6.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3338) FERM_M PF00373.18 EMC82171.1 - 2.2e-20 73.2 3.7 3.4e-20 72.6 0.0 2.9 3 0 0 3 3 3 1 FERM central domain FERM_C PF09380.10 EMC82171.1 - 2.6e-09 37.4 0.1 2.6e-08 34.1 0.1 2.4 1 1 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.10 EMC82171.1 - 8.5e-09 35.2 0.1 2.3e-08 33.8 0.1 1.7 1 0 0 1 1 1 1 FERM N-terminal domain DUF4379 PF14311.6 EMC82171.1 - 0.019 15.3 0.3 0.057 13.8 0.3 1.8 1 0 0 1 1 1 0 Probable Zinc-ribbon domain Myosin_tail_1 PF01576.19 EMC82172.1 - 5.9e-68 229.7 125.8 8.2e-68 229.2 125.8 1.2 1 0 0 1 1 1 1 Myosin tail DUF1664 PF07889.12 EMC82172.1 - 7.7e-06 26.0 74.5 0.0009 19.3 9.7 7.3 2 1 6 8 8 8 4 Protein of unknown function (DUF1664) IQ PF00612.27 EMC82172.1 - 1e-05 24.8 1.0 0.00022 20.8 0.2 2.7 2 0 0 2 2 2 1 IQ calmodulin-binding motif KASH_CCD PF14662.6 EMC82172.1 - 0.0054 16.6 117.1 0.041 13.7 10.6 5.5 1 1 4 5 5 5 2 Coiled-coil region of CCDC155 or KASH GAS PF13851.6 EMC82172.1 - 0.021 14.2 122.0 0.48 9.7 26.4 6.5 1 1 5 6 6 6 0 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 EMC82172.1 - 0.033 14.4 116.7 0.087 13.0 28.3 6.3 1 1 5 6 6 6 0 Autophagy protein 16 (ATG16) DUF3450 PF11932.8 EMC82172.1 - 0.13 11.6 100.4 0.096 12.0 7.7 6.5 1 1 8 9 9 9 0 Protein of unknown function (DUF3450) Filament PF00038.21 EMC82172.1 - 0.22 11.1 105.4 0.011 15.4 55.2 5.0 1 1 3 4 4 4 0 Intermediate filament protein DUF4686 PF15742.5 EMC82172.1 - 0.24 10.5 116.7 11 5.1 65.4 3.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4686) ADIP PF11559.8 EMC82172.1 - 0.35 10.9 107.3 0.058 13.5 19.5 6.3 1 1 4 6 6 6 0 Afadin- and alpha -actinin-Binding Tektin PF03148.14 EMC82172.1 - 0.49 9.1 94.4 0.013 14.3 16.3 5.2 1 1 3 4 4 4 0 Tektin family ERM PF00769.19 EMC82172.1 - 0.55 10.0 133.1 2.9 7.7 17.3 5.4 1 1 4 5 5 5 0 Ezrin/radixin/moesin family TPR_MLP1_2 PF07926.12 EMC82172.1 - 1.2 9.2 121.4 0.57 10.2 9.2 6.4 1 1 6 7 7 7 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 EMC82172.1 - 1.5 7.6 120.9 0.033 13.1 21.5 5.3 1 1 4 5 5 5 0 Spc7 kinetochore protein DUF3584 PF12128.8 EMC82172.1 - 1.6 6.1 105.5 0.051 11.1 47.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) APG6_N PF17675.1 EMC82172.1 - 1.8 9.1 137.9 21 5.6 35.6 6.9 1 1 4 5 5 4 0 Apg6 coiled-coil region Mating_N PF12731.7 EMC82172.1 - 4.3 7.5 12.3 6.3 7.0 0.5 4.5 3 2 1 4 4 4 0 Mating-type protein beta 1 Myosin_head PF00063.21 EMC82173.1 - 4.7e-181 603.5 6.5 5.3e-127 424.8 3.8 2.0 1 1 1 2 2 2 2 Myosin head (motor domain) Myosin_N PF02736.19 EMC82173.1 - 4.3e-15 55.3 0.6 4.3e-15 55.3 0.6 1.9 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain AAA_22 PF13401.6 EMC82173.1 - 0.0057 16.9 0.0 0.014 15.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain Cupin_3 PF05899.12 EMC82173.1 - 0.048 13.4 0.1 2 8.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF861) AAA_16 PF13191.6 EMC82173.1 - 0.096 13.1 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain DUF4537 PF15057.6 EMC82173.1 - 0.099 12.7 0.1 3.2 7.8 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4537) Sigma54_activat PF00158.26 EMC82173.1 - 0.11 12.2 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_7 PF12775.7 EMC82173.1 - 0.11 12.0 0.0 0.28 10.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region T2SSE PF00437.20 EMC82173.1 - 0.16 11.0 0.0 0.32 10.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Myosin_N PF02736.19 EMC82174.1 - 1.8e-12 46.9 0.3 2.6e-12 46.3 0.3 1.2 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Myosin_head PF00063.21 EMC82175.1 - 1.4e-289 962.1 2.7 1.4e-289 962.1 2.7 3.3 5 0 0 5 5 5 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 EMC82175.1 - 4.7e-154 514.8 267.5 6.1e-154 514.4 267.5 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.19 EMC82175.1 - 4.7e-14 51.9 1.2 1.4e-13 50.4 1.2 1.9 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain TSNAXIP1_N PF15739.5 EMC82175.1 - 0.01 16.2 7.6 0.01 16.2 7.6 15.2 4 3 11 15 15 15 0 Translin-associated factor X-interacting N-terminus IQ PF00612.27 EMC82175.1 - 0.022 14.5 2.8 0.076 12.8 0.6 2.7 2 0 0 2 2 2 0 IQ calmodulin-binding motif AAA_22 PF13401.6 EMC82175.1 - 0.094 13.0 0.0 0.094 13.0 0.0 5.4 3 2 1 5 5 5 0 AAA domain AAA_16 PF13191.6 EMC82175.1 - 0.74 10.2 0.0 0.74 10.2 0.0 6.2 2 1 0 2 2 2 0 AAA ATPase domain Myosin_head PF00063.21 EMC82176.1 - 4.8e-282 937.2 3.3 4.8e-282 937.2 3.3 4.2 5 0 0 5 5 5 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 EMC82176.1 - 3.6e-140 468.8 256.7 4.3e-140 468.6 256.7 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.19 EMC82176.1 - 1.5e-10 40.7 2.3 4.7e-10 39.1 2.3 1.9 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain IQ PF00612.27 EMC82176.1 - 0.0013 18.3 1.3 0.044 13.6 0.1 2.9 2 0 0 2 2 2 1 IQ calmodulin-binding motif AAA_22 PF13401.6 EMC82176.1 - 0.093 13.0 0.0 0.093 13.0 0.0 5.1 3 2 1 4 4 4 0 AAA domain AAA_16 PF13191.6 EMC82176.1 - 0.52 10.7 0.0 0.52 10.7 0.0 5.9 5 2 1 6 6 6 0 AAA ATPase domain SCO1-SenC PF02630.14 EMC82177.1 - 8.2e-43 145.5 0.0 8.8e-43 145.4 0.0 1.0 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 EMC82177.1 - 3.4e-06 27.0 0.0 5.2e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 EMC82177.1 - 0.0011 19.2 0.0 0.0015 18.8 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Metallophos PF00149.28 EMC82178.1 - 0.0014 19.1 0.1 0.0017 18.9 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ELYS-bb PF16687.5 EMC82180.1 - 1.5e-297 986.9 0.0 1.8e-297 986.6 0.0 1.1 1 0 0 1 1 1 1 beta-propeller of ELYS nucleoporin ELYS PF13934.6 EMC82180.1 - 0.00011 22.3 0.0 0.00031 20.8 0.0 1.7 1 0 0 1 1 1 1 Nuclear pore complex assembly DTW PF03942.15 EMC82182.1 - 1.2e-45 155.6 0.0 2e-45 154.9 0.0 1.4 1 0 0 1 1 1 1 DTW domain FGF PF00167.18 EMC82183.1 - 6.2e-49 165.2 1.9 8e-49 164.9 1.9 1.1 1 0 0 1 1 1 1 Fibroblast growth factor Ribosomal_L7Ae PF01248.26 EMC82185.1 - 3.9e-22 77.8 0.0 1.5e-21 75.9 0.0 2.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PID PF00640.23 EMC82186.1 - 5.4e-46 156.1 0.1 9.9e-46 155.2 0.1 1.5 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH2 PF00017.24 EMC82186.1 - 4.5e-16 58.7 0.1 1.9e-15 56.7 0.0 2.1 2 0 0 2 2 2 1 SH2 domain PTB PF08416.13 EMC82186.1 - 0.11 12.7 0.3 0.47 10.6 0.0 2.1 3 0 0 3 3 3 0 Phosphotyrosine-binding domain EGF_CA PF07645.15 EMC82189.1 - 0 1062.3 724.8 2.6e-11 43.5 7.5 48.7 48 1 1 49 49 49 44 Calcium-binding EGF domain cEGF PF12662.7 EMC82189.1 - 7.4e-214 690.8 419.6 2.1e-09 37.1 1.2 50.5 49 0 0 49 49 49 42 Complement Clr-like EGF-like TB PF00683.17 EMC82189.1 - 5.7e-117 381.3 148.8 2.9e-15 55.7 9.5 11.2 9 0 0 9 9 9 9 TB domain EGF PF00008.27 EMC82189.1 - 4.9e-112 365.6 700.1 0.00025 21.2 7.8 50.3 49 0 0 49 49 49 45 EGF-like domain hEGF PF12661.7 EMC82189.1 - 8.8e-100 324.3 664.0 0.00011 22.7 4.4 52.5 51 0 0 51 51 51 42 Human growth factor-like EGF FXa_inhibition PF14670.6 EMC82189.1 - 1.4e-99 326.1 726.6 4.6e-10 39.6 9.2 49.6 44 5 6 50 50 50 41 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 EMC82189.1 - 7.4e-59 195.6 622.5 1.7e-10 40.9 12.7 49.4 49 1 1 50 50 50 40 EGF domain Fibrillin_U_N PF18193.1 EMC82189.1 - 4.7e-16 58.6 7.4 4.7e-16 58.6 7.4 8.8 8 0 0 8 8 8 1 Fibrillin 1 unique N-terminal domain Plasmod_Pvs28 PF06247.11 EMC82189.1 - 2.1e-13 50.3 531.6 0.0025 18.1 8.4 45.7 43 2 2 45 45 45 25 Pvs28 EGF domain EGF_MSP1_1 PF12946.7 EMC82189.1 - 0.0011 19.0 21.7 0.0013 18.7 6.3 43.6 44 2 2 46 46 46 15 MSP1 EGF domain 1 dUTPase PF00692.19 EMC82190.1 - 2.3e-50 169.6 0.0 2.7e-50 169.4 0.0 1.1 1 0 0 1 1 1 1 dUTPase AA_permease PF00324.21 EMC82191.1 - 1.1e-150 502.4 37.8 1.3e-150 502.1 37.8 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 EMC82191.1 - 2e-140 468.6 5.2 5.8e-138 460.5 5.2 2.2 1 1 0 1 1 1 1 Solute carrier family 12 AA_permease_N PF08403.10 EMC82191.1 - 1.4e-32 111.0 0.0 6.7e-31 105.6 0.1 2.5 2 0 0 2 2 2 1 Amino acid permease N-terminal AA_permease_2 PF13520.6 EMC82191.1 - 4.4e-22 78.5 42.7 7e-22 77.8 42.7 1.2 1 0 0 1 1 1 1 Amino acid permease DUF1682 PF07946.14 EMC82191.1 - 0.06 12.6 0.5 0.12 11.6 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DUF2312 PF10073.9 EMC82191.1 - 0.12 12.1 0.4 0.34 10.6 0.4 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) Cortexin PF11057.8 EMC82192.1 - 7.6e-41 137.8 0.1 8.7e-41 137.7 0.1 1.0 1 0 0 1 1 1 1 Cortexin of kidney RRM_1 PF00076.22 EMC82193.1 - 9.9e-57 188.7 0.5 1.1e-19 70.0 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EMC82193.1 - 3.6e-08 33.4 0.4 0.0027 17.7 0.0 3.1 3 0 0 3 3 3 2 RNA binding motif Limkain-b1 PF11608.8 EMC82193.1 - 3.1e-06 27.1 0.1 0.0078 16.3 0.0 2.8 2 0 0 2 2 2 2 Limkain b1 RRM_5 PF13893.6 EMC82193.1 - 5.8e-05 22.7 0.0 0.054 13.1 0.0 3.1 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMC82193.1 - 0.0037 17.1 0.0 0.78 9.6 0.0 2.5 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_Rrp7 PF17799.1 EMC82193.1 - 0.0057 16.5 0.1 18 5.1 0.0 3.7 3 1 1 4 4 4 1 Rrp7 RRM-like N-terminal domain DUF3932 PF13068.6 EMC82193.1 - 0.0074 16.5 0.0 1.5 9.1 0.0 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF3932) DbpA PF03880.15 EMC82193.1 - 0.069 13.2 0.0 11 6.1 0.0 2.6 2 0 0 2 2 2 0 DbpA RNA binding domain Na_Ca_ex PF01699.24 EMC82194.1 - 5.3e-50 169.3 41.8 4.1e-28 98.2 18.2 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF2456 PF10445.9 EMC82194.1 - 0.76 9.9 6.3 0.85 9.7 1.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2456) SPC25 PF06703.11 EMC82194.1 - 1.5 8.6 7.7 0.32 10.8 0.9 2.3 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Sema PF01403.19 EMC82195.1 - 2e-118 395.9 0.0 4.2e-118 394.8 0.0 1.4 1 0 0 1 1 1 1 Sema domain PSI PF01437.25 EMC82195.1 - 7.3e-06 26.4 1.1 1.8e-05 25.1 1.1 1.7 1 0 0 1 1 1 1 Plexin repeat PP1_bind PF15276.6 EMC82195.1 - 3 8.2 6.6 2.5 8.5 0.6 2.8 2 0 0 2 2 2 0 Protein phosphatase 1 binding OLF PF02191.16 EMC82196.1 - 4.9e-64 216.3 2.1 5.7e-64 216.0 2.1 1.0 1 0 0 1 1 1 1 Olfactomedin-like domain Collagen PF01391.18 EMC82196.1 - 7.6e-16 57.6 65.6 5.3e-10 38.9 27.4 3.1 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) DUF758 PF05527.11 EMC82197.1 - 9.8e-81 270.1 7.1 1.1e-80 269.9 7.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF758) Seadorna_VP6 PF07407.11 EMC82197.1 - 0.019 14.0 1.2 0.027 13.4 0.4 1.4 1 1 0 1 1 1 0 Seadornavirus VP6 protein RPAP3_C PF13877.6 EMC82197.1 - 0.029 14.9 1.3 0.076 13.6 0.7 1.9 2 1 0 2 2 2 0 Potential Monad-binding region of RPAP3 Rsd_AlgQ PF04353.13 EMC82197.1 - 0.041 13.8 3.3 2.3 8.1 0.3 2.1 1 1 1 2 2 2 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ DUF2408 PF10303.9 EMC82197.1 - 0.071 13.7 1.9 0.46 11.0 1.8 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) DALR_1 PF05746.15 EMC82197.1 - 0.14 12.3 2.0 0.22 11.7 1.6 1.5 1 1 0 1 1 1 0 DALR anticodon binding domain Adaptin_N PF01602.20 EMC82198.1 - 9.5e-87 291.7 5.3 1.2e-86 291.4 5.3 1.1 1 0 0 1 1 1 1 Adaptin N terminal region AP4E_app_platf PF14807.6 EMC82198.1 - 6.3e-34 116.3 0.0 1.8e-33 114.8 0.0 1.9 1 0 0 1 1 1 1 Adaptin AP4 complex epsilon appendage platform Cnd1 PF12717.7 EMC82198.1 - 2.6e-05 24.3 0.9 0.001 19.1 0.0 3.3 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Coatomer_b_Cpla PF14806.6 EMC82198.1 - 0.0013 18.8 0.0 0.0028 17.6 0.0 1.5 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 EMC82198.1 - 0.0044 16.9 0.0 0.0098 15.8 0.0 1.6 1 0 0 1 1 1 1 Coatomer beta C-terminal region B2-adapt-app_C PF09066.10 EMC82198.1 - 0.048 13.7 0.0 0.19 11.8 0.0 2.0 1 0 0 1 1 1 0 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.6 EMC82198.1 - 0.09 13.2 0.1 3.2 8.2 0.0 3.5 4 0 0 4 4 4 0 HEAT repeats HEAT_EZ PF13513.6 EMC82198.1 - 0.099 13.2 0.0 12 6.6 0.0 4.0 4 0 0 4 4 4 0 HEAT-like repeat HEAT PF02985.22 EMC82198.1 - 0.11 12.8 0.0 14 6.2 0.0 4.1 4 0 0 4 4 4 0 HEAT repeat SGIII PF15467.6 EMC82199.1 - 1.2e-212 707.1 32.0 1.4e-212 706.9 32.0 1.0 1 0 0 1 1 1 1 Secretogranin-3 DUF2680 PF10925.8 EMC82199.1 - 3.4e-05 23.7 12.4 0.1 12.6 0.2 4.6 5 0 0 5 5 5 3 Protein of unknown function (DUF2680) CtsR_C PF17727.1 EMC82199.1 - 0.18 11.9 2.2 12 6.1 0.3 3.9 4 0 0 4 4 4 0 CtsR C-terminal dimerization domain ParE_toxin PF05016.15 EMC82199.1 - 0.59 10.8 2.8 2.1 9.0 0.1 3.0 3 1 1 4 4 4 0 ParE toxin of type II toxin-antitoxin system, parDE Hormone_2 PF00123.20 EMC82200.1 - 1.8 8.5 0.0 1.8 8.5 0.0 2.4 3 0 0 3 3 3 0 Peptide hormone Tropomodulin PF03250.14 EMC82201.1 - 2.6e-60 202.6 4.6 2.6e-60 202.6 4.6 1.8 2 0 0 2 2 2 1 Tropomodulin LRR_6 PF13516.6 EMC82201.1 - 0.056 13.5 3.4 0.1 12.7 0.1 2.9 3 0 0 3 3 3 0 Leucine Rich repeat LRR_4 PF12799.7 EMC82201.1 - 1.1 9.7 6.8 3.5 8.2 0.1 3.2 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) Tropomodulin PF03250.14 EMC82202.1 - 3.1e-58 195.8 5.2 3.1e-58 195.8 5.2 1.7 2 0 0 2 2 2 1 Tropomodulin LRR_6 PF13516.6 EMC82202.1 - 0.0092 16.0 1.4 0.017 15.2 0.1 2.2 2 0 0 2 2 2 1 Leucine Rich repeat Secretogranin_V PF05281.11 EMC82202.1 - 0.024 14.3 0.0 0.056 13.1 0.0 1.6 1 0 0 1 1 1 0 Neuroendocrine protein 7B2 precursor (Secretogranin V) PARP_reg PF02877.14 EMC82202.1 - 0.076 13.1 0.1 12 6.0 0.0 2.6 2 0 0 2 2 2 0 Poly(ADP-ribose) polymerase, regulatory domain Ribosomal_S13 PF00416.22 EMC82202.1 - 0.18 12.2 0.6 1.4 9.3 0.1 2.3 2 0 0 2 2 2 0 Ribosomal protein S13/S18 LRR_4 PF12799.7 EMC82202.1 - 1.6 9.2 4.4 4.2 7.9 0.2 3.1 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) Leo1 PF04004.13 EMC82203.1 - 4.8e-54 182.6 0.0 4.8e-54 182.6 0.0 3.4 2 1 0 2 2 2 1 Leo1-like protein Ion_trans PF00520.31 EMC82204.1 - 5.4e-10 38.9 0.8 5.9e-10 38.8 0.8 1.0 1 0 0 1 1 1 1 Ion transport protein DUF423 PF04241.15 EMC82204.1 - 0.012 15.8 0.5 0.013 15.7 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF423) Peptidase_C2 PF00648.21 EMC82205.1 - 2.9e-19 69.2 0.0 3.4e-19 69.0 0.0 1.0 1 0 0 1 1 1 1 Calpain family cysteine protease 7tm_1 PF00001.21 EMC82207.1 - 2.8e-22 79.3 2.7 3.6e-22 79.0 2.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC82207.1 - 8.4e-21 74.9 3.5 9.6e-21 74.7 3.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_4 PF13853.6 EMC82208.1 - 5.2e-40 137.9 13.6 6.1e-40 137.7 13.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC82208.1 - 1.6e-24 86.7 15.9 2.6e-24 86.0 15.9 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC82208.1 - 0.0035 17.0 8.2 0.0035 17.0 8.2 2.1 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Nucleos_tra2_C PF07662.13 EMC82211.1 - 2e-76 256.5 5.2 2e-76 256.5 5.2 2.3 2 0 0 2 2 2 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 EMC82211.1 - 9.5e-23 80.6 3.8 9.5e-23 80.6 3.8 3.1 5 0 0 5 5 5 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.14 EMC82211.1 - 3.2e-06 27.4 8.9 3.2e-06 27.4 8.9 3.9 4 0 0 4 4 4 1 Nucleoside recognition Aminopep PF10023.9 EMC82211.1 - 0.1 11.9 0.1 0.16 11.3 0.1 1.2 1 0 0 1 1 1 0 Putative aminopeptidase RMI1_N PF08585.12 EMC82213.1 - 3.9e-53 180.4 0.3 7.6e-53 179.5 0.3 1.5 1 0 0 1 1 1 1 RecQ mediated genome instability protein RMI1_C PF16099.5 EMC82213.1 - 1.3e-46 158.0 0.9 4.3e-46 156.3 0.0 2.3 3 0 0 3 3 3 1 Recq-mediated genome instability protein 1, C-terminal OB-fold KH_1 PF00013.29 EMC82214.1 - 3.5e-41 138.9 13.4 2.4e-17 62.5 1.5 3.3 3 0 0 3 3 3 3 KH domain ROKNT PF08067.11 EMC82214.1 - 9.3e-24 83.4 10.4 7.9e-23 80.5 11.6 1.9 2 0 0 2 2 2 1 ROKNT (NUC014) domain KH_2 PF07650.17 EMC82214.1 - 3.7e-12 45.9 10.9 0.00069 19.4 0.1 3.9 2 1 1 4 4 4 3 KH domain KH_4 PF13083.6 EMC82214.1 - 3.3e-08 33.3 3.5 3.2e-06 26.9 0.0 3.3 3 0 0 3 3 3 1 KH domain KH_5 PF13184.6 EMC82214.1 - 0.0037 17.3 6.1 3 8.0 0.4 3.7 3 1 0 3 3 3 2 NusA-like KH domain DJ-1_PfpI PF01965.24 EMC82214.1 - 0.037 13.8 0.0 0.12 12.2 0.0 1.7 2 0 0 2 2 2 0 DJ-1/PfpI family Kinesin PF00225.23 EMC82215.1 - 2.7e-109 365.1 1.7 2.7e-109 365.1 1.7 3.2 4 0 0 4 4 4 1 Kinesin motor domain Microtub_bd PF16796.5 EMC82215.1 - 4.3e-24 85.1 0.0 4.3e-24 85.1 0.0 2.9 3 0 0 3 3 3 1 Microtubule binding HetR_C PF18460.1 EMC82216.1 - 0.12 12.3 1.3 0.37 10.8 0.8 2.0 1 1 1 2 2 2 0 Heterocyst differentiation regulator C-terminal Hood domain DUF4436 PF14494.6 EMC82216.1 - 0.14 11.5 0.4 0.23 10.7 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4436) SKI PF01202.22 EMC82217.1 - 5.7e-05 23.3 0.0 0.0011 19.1 0.0 2.1 1 1 0 1 1 1 1 Shikimate kinase FERM_M PF00373.18 EMC82218.1 - 1.2e-18 67.6 0.2 2.9e-18 66.4 0.0 1.8 2 0 0 2 2 2 1 FERM central domain FERM_C PF09380.10 EMC82218.1 - 5.4e-17 62.0 0.4 1.1e-16 61.0 0.4 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FA PF08736.11 EMC82218.1 - 4.1e-14 52.4 2.2 8.3e-14 51.4 2.2 1.5 1 0 0 1 1 1 1 FERM adjacent (FA) FERM_N PF09379.10 EMC82218.1 - 1.1e-11 44.5 0.0 2.1e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 FERM N-terminal domain Ras PF00071.22 EMC82219.1 - 2.1e-50 170.5 0.1 2.1e-50 170.5 0.1 1.9 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EMC82219.1 - 1.3e-30 106.0 0.0 4.2e-30 104.4 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC82219.1 - 7.9e-16 58.0 0.0 7.9e-16 58.0 0.0 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC82219.1 - 2.3e-08 34.1 1.3 3.5e-08 33.5 0.0 2.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC82219.1 - 0.00037 20.1 0.0 0.00037 20.1 0.0 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_33 PF13671.6 EMC82219.1 - 0.14 12.3 0.0 0.14 12.3 0.0 3.4 4 1 0 4 4 4 0 AAA domain RsgA_GTPase PF03193.16 EMC82219.1 - 0.25 11.3 5.3 4.6 7.1 0.0 3.4 3 1 0 4 4 4 0 RsgA GTPase TTKRSYEDQ PF10212.9 EMC82219.1 - 0.88 8.5 23.6 0.28 10.2 20.2 1.9 2 1 0 2 2 2 0 Predicted coiled-coil domain-containing protein DUF2514 PF10721.9 EMC82219.1 - 1.1 9.2 7.6 3.2 7.8 7.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) NitrOD5 PF11537.8 EMC82219.1 - 5.6 7.2 9.4 3.6 7.8 4.9 2.8 3 0 0 3 3 3 0 Nitrosopumilus output domain 5 FUSC-like PF12805.7 EMC82219.1 - 6.6 5.7 9.7 0.13 11.3 2.5 1.8 2 0 0 2 2 2 0 FUSC-like inner membrane protein yccS GIT_CC PF16559.5 EMC82219.1 - 7.7 6.5 16.3 7.5 6.5 2.5 4.0 2 1 3 5 5 5 0 GIT coiled-coil Rho guanine nucleotide exchange factor LRR_8 PF13855.6 EMC82220.1 - 3.8e-91 298.8 94.9 7.4e-16 57.7 1.7 7.9 2 1 7 10 10 10 10 Leucine rich repeat I-set PF07679.16 EMC82220.1 - 6.1e-49 164.0 0.0 2.7e-19 69.0 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC82220.1 - 3.7e-44 149.2 0.0 4.3e-14 52.9 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain LRR_4 PF12799.7 EMC82220.1 - 7.8e-35 118.3 58.2 4.3e-06 27.0 0.5 10.2 4 2 8 13 13 13 12 Leucine Rich repeats (2 copies) Ig_2 PF13895.6 EMC82220.1 - 3.3e-28 97.8 0.0 1.5e-07 31.6 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain LRR_5 PF13306.6 EMC82220.1 - 5.5e-27 94.3 7.1 3.7e-11 43.1 0.0 4.5 2 1 3 5 5 5 4 BspA type Leucine rich repeat region (6 copies) ig PF00047.25 EMC82220.1 - 3.4e-26 91.2 0.0 6.8e-07 29.4 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain LRR_9 PF14580.6 EMC82220.1 - 1.5e-18 66.9 19.2 2.3e-05 24.0 0.7 5.4 1 1 4 5 5 5 5 Leucine-rich repeat V-set PF07686.17 EMC82220.1 - 9.4e-12 45.1 3.0 0.037 14.2 0.1 5.7 3 3 1 4 4 4 3 Immunoglobulin V-set domain LRR_1 PF00560.33 EMC82220.1 - 5.6e-09 35.3 39.1 0.9 10.3 1.0 13.8 14 1 0 14 14 14 2 Leucine Rich Repeat Ig_6 PF18452.1 EMC82220.1 - 8.3e-09 34.9 0.0 0.04 13.5 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 EMC82220.1 - 1.1e-08 35.1 0.1 0.0039 17.2 0.0 4.3 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 EMC82220.1 - 3.9e-06 27.2 0.0 0.42 11.0 0.0 4.5 3 1 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 EMC82220.1 - 0.00012 22.1 1.1 3.5 7.8 0.0 4.2 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain C1-set PF07654.15 EMC82220.1 - 0.0014 19.0 0.1 0.023 15.0 0.0 2.8 3 0 0 3 3 3 1 Immunoglobulin C1-set domain C2-set PF05790.15 EMC82220.1 - 0.085 13.1 0.1 11 6.3 0.0 3.6 5 0 0 5 5 2 0 Immunoglobulin C2-set domain Receptor_2B4 PF11465.8 EMC82220.1 - 0.12 12.6 0.0 3.2 8.0 0.0 2.7 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 LRRCT PF01463.24 EMC82220.1 - 0.13 12.9 0.3 4.7 8.0 0.0 3.3 3 0 0 3 3 2 0 Leucine rich repeat C-terminal domain LRR_6 PF13516.6 EMC82220.1 - 0.66 10.2 56.1 1.6 9.0 0.1 13.2 15 0 0 15 15 14 0 Leucine Rich repeat Ribosomal_S27e PF01667.17 EMC82221.1 - 4.1e-22 77.6 4.8 4.5e-22 77.5 4.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S27 Ras PF00071.22 EMC82222.1 - 1.2e-17 64.0 0.1 1.3e-17 63.9 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC82222.1 - 1.4e-12 47.9 0.1 1.5e-12 47.7 0.1 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC82222.1 - 0.011 15.3 0.0 0.011 15.2 0.0 1.0 1 0 0 1 1 1 0 ADP-ribosylation factor family PduV-EutP PF10662.9 EMC82222.1 - 0.038 13.7 0.0 0.038 13.7 0.0 1.0 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 EMC82222.1 - 0.066 12.7 0.0 0.067 12.7 0.0 1.0 1 0 0 1 1 1 0 P-loop containing dynein motor region SRPRB PF09439.10 EMC82222.1 - 0.092 12.2 0.0 0.098 12.1 0.0 1.0 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit JTB PF05439.12 EMC82223.1 - 2.2e-23 82.4 3.2 2.3e-23 82.3 3.2 1.0 1 0 0 1 1 1 1 Jumping translocation breakpoint protein (JTB) DUF5129 PF17173.4 EMC82223.1 - 0.072 12.2 0.3 0.074 12.2 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5129) bZIP_1 PF00170.21 EMC82224.1 - 1.2e-06 28.6 5.4 1.2e-06 28.6 5.4 1.7 1 1 1 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EMC82224.1 - 0.00063 19.8 5.0 0.00063 19.8 5.0 1.9 1 1 1 2 2 2 2 Basic region leucine zipper ZapB PF06005.12 EMC82224.1 - 0.005 17.2 3.7 0.0066 16.9 3.7 1.1 1 0 0 1 1 1 1 Cell division protein ZapB OmpH PF03938.14 EMC82224.1 - 0.029 14.7 0.3 0.033 14.5 0.3 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) SlyX PF04102.12 EMC82224.1 - 0.041 14.5 0.4 0.058 14.0 0.4 1.2 1 0 0 1 1 1 0 SlyX DUF3287 PF11690.8 EMC82224.1 - 0.059 13.1 0.0 0.065 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) FlaC_arch PF05377.11 EMC82224.1 - 0.082 13.3 0.1 0.11 13.0 0.1 1.2 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF677 PF05055.12 EMC82224.1 - 0.13 11.1 0.0 0.17 10.8 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF677) DUF4570 PF15134.6 EMC82224.1 - 0.19 11.8 2.5 0.25 11.4 2.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) HALZ PF02183.18 EMC82224.1 - 0.29 11.4 4.5 0.26 11.5 0.6 2.1 1 1 1 2 2 2 0 Homeobox associated leucine zipper M PF02370.16 EMC82224.1 - 0.96 10.2 5.0 0.78 10.5 2.9 2.0 1 1 1 2 2 2 0 M protein repeat GAS2 PF02187.17 EMC82227.1 - 1.8e-26 92.0 0.0 3.3e-26 91.2 0.0 1.5 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain CH PF00307.31 EMC82227.1 - 3.5e-10 40.0 0.0 7.6e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain zf-C4 PF00105.18 EMC82228.1 - 8.6e-29 99.8 14.7 8.6e-29 99.8 14.7 1.7 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 EMC82228.1 - 6.4e-26 91.2 0.9 6.4e-26 91.2 0.9 2.4 2 1 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor MFS_1 PF07690.16 EMC82229.1 - 3.4e-28 98.6 27.9 1.2e-15 57.3 0.8 3.5 2 1 1 3 3 3 3 Major Facilitator Superfamily Oxidored_q5_N PF01059.17 EMC82229.1 - 0.42 10.7 6.8 0.96 9.6 0.1 2.7 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase chain 4, amino terminus Pkinase PF00069.25 EMC82230.1 - 1.4e-25 90.1 0.0 2.9e-25 89.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC82230.1 - 3.7e-14 52.6 0.0 1.9e-13 50.3 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase XRN_M PF17846.1 EMC82230.1 - 0.014 14.4 1.3 0.028 13.4 1.3 1.4 1 0 0 1 1 1 0 Xrn1 helical domain Ank_4 PF13637.6 EMC82231.1 - 3.3e-20 72.2 2.2 1.7e-08 34.9 0.2 5.0 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC82231.1 - 7.4e-20 71.3 0.4 2.1e-16 60.3 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EMC82231.1 - 4.2e-17 61.7 0.5 0.0002 21.6 0.2 5.0 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 EMC82231.1 - 2.8e-13 48.7 0.3 0.0012 19.1 0.0 4.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EMC82231.1 - 3.8e-13 49.4 1.0 0.00019 21.6 0.2 3.6 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Prefoldin_2 PF01920.20 EMC82231.1 - 0.017 15.1 14.4 0.029 14.3 14.4 1.4 1 0 0 1 1 1 0 Prefoldin subunit SlyX PF04102.12 EMC82231.1 - 0.12 13.0 14.7 0.25 12.0 3.4 3.1 2 0 0 2 2 2 0 SlyX Fib_alpha PF08702.10 EMC82231.1 - 0.14 12.3 7.8 1 9.6 2.7 2.4 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family HIP1_clath_bdg PF16515.5 EMC82231.1 - 0.36 11.5 18.8 1.4 9.5 1.8 2.7 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CENP-F_leu_zip PF10473.9 EMC82231.1 - 0.38 10.8 22.8 0.031 14.3 11.0 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 EMC82231.1 - 1 9.6 26.4 5.3 7.2 13.6 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Spectrin PF00435.21 EMC82231.1 - 1.5 9.3 19.0 0.42 11.1 3.2 3.2 1 1 2 3 3 3 0 Spectrin repeat Prominin PF05478.11 EMC82231.1 - 1.6 6.6 7.9 2.3 6.0 7.9 1.1 1 0 0 1 1 1 0 Prominin Xan_ur_permease PF00860.20 EMC82232.1 - 3.5e-90 302.5 25.8 4.6e-90 302.1 25.8 1.1 1 0 0 1 1 1 1 Permease family zf-RING_4 PF14570.6 EMC82233.1 - 3.5e-20 71.5 12.2 6.2e-20 70.7 12.2 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 EMC82233.1 - 1.7e-06 27.8 7.4 3.3e-06 26.8 7.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.22 EMC82233.1 - 8.4e-06 25.5 0.0 1.9e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING_2 PF13639.6 EMC82233.1 - 0.0035 17.7 11.0 0.0077 16.5 11.0 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC82233.1 - 0.028 14.2 10.4 0.062 13.2 10.4 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC82233.1 - 0.035 14.0 9.9 0.075 12.9 9.9 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-UDP PF14569.6 EMC82233.1 - 0.053 13.6 3.6 0.14 12.3 3.6 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-RING_5 PF14634.6 EMC82233.1 - 0.43 10.6 8.9 0.84 9.7 8.9 1.5 1 0 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC82233.1 - 1.8 8.5 9.7 48 3.9 9.9 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Nup192 PF11894.8 EMC82234.1 - 0 1307.1 7.7 0 1306.9 7.7 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 Arf PF00025.21 EMC82235.1 - 1.3e-75 252.7 0.1 1.4e-75 252.6 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EMC82235.1 - 3.7e-15 56.2 0.1 4.8e-15 55.8 0.1 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMC82235.1 - 1.8e-13 50.4 0.0 2.1e-13 50.2 0.0 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EMC82235.1 - 1.7e-11 43.9 0.0 2e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EMC82235.1 - 2.9e-11 43.1 0.6 3.4e-07 29.7 0.1 2.5 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EMC82235.1 - 3e-10 39.8 0.0 3.8e-10 39.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMC82235.1 - 1.4e-05 25.2 0.0 2.4e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase MeaB PF03308.16 EMC82235.1 - 0.0013 17.7 0.4 0.047 12.7 0.0 2.4 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 EMC82235.1 - 0.0061 16.1 0.3 0.048 13.2 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 EMC82235.1 - 0.017 15.7 0.3 0.095 13.2 0.3 1.9 1 1 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 EMC82235.1 - 0.018 15.6 0.0 0.024 15.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.18 EMC82235.1 - 0.02 14.5 0.8 0.13 11.8 0.8 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B cobW PF02492.19 EMC82235.1 - 0.082 12.5 0.3 8.2 6.0 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EMC82235.1 - 0.083 12.8 0.1 13 5.7 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 EMC82235.1 - 0.14 11.9 0.3 3.9 7.2 0.1 2.5 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 EMC82235.1 - 0.19 12.1 0.1 3.6 8.0 0.1 2.1 2 0 0 2 2 2 0 AAA ATPase domain DRIM PF07539.12 EMC82236.1 - 9.3e-181 602.3 20.1 9.3e-181 602.3 20.1 3.4 4 0 0 4 4 4 1 Down-regulated in metastasis HEAT_2 PF13646.6 EMC82236.1 - 0.0048 17.3 0.1 0.37 11.2 0.0 4.4 5 0 0 5 5 5 1 HEAT repeats HEAT PF02985.22 EMC82236.1 - 0.015 15.5 2.5 49 4.6 0.2 5.8 6 0 0 6 6 6 0 HEAT repeat Arm PF00514.23 EMC82236.1 - 0.71 10.0 5.5 25 5.1 0.1 4.2 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Anoctamin PF04547.12 EMC82237.1 - 3e-162 540.6 12.9 3.6e-162 540.3 12.9 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 EMC82237.1 - 4e-75 252.4 2.6 7.2e-75 251.6 2.6 1.4 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Syja_N PF02383.18 EMC82238.1 - 6.2e-57 193.3 0.0 1.1e-56 192.5 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain WH2 PF02205.20 EMC82239.1 - 1.5e-07 31.0 0.1 2.6e-07 30.2 0.1 1.4 1 0 0 1 1 1 1 WH2 motif WD40 PF00400.32 EMC82240.1 - 1.2e-37 127.2 11.5 2e-06 28.4 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC82240.1 - 1.6e-11 44.3 0.2 0.008 16.4 0.1 4.9 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC82240.1 - 0.0051 16.7 0.5 2.1 8.2 0.0 3.1 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 EMC82240.1 - 0.04 13.5 0.0 0.13 11.8 0.1 1.8 2 1 0 2 2 2 0 PQQ-like domain Methyltransf_22 PF13383.6 EMC82241.1 - 7.5e-12 45.3 0.3 8.6e-12 45.2 0.3 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_21 PF05050.12 EMC82241.1 - 1.6e-05 25.0 0.0 2.4e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain DAO PF01266.24 EMC82242.1 - 8.7e-34 117.6 0.0 9.9e-34 117.5 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EMC82242.1 - 0.014 15.9 0.2 3.1 8.4 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF2367 PF10164.9 EMC82242.1 - 0.024 15.1 0.4 0.046 14.2 0.4 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) NAD_binding_8 PF13450.6 EMC82242.1 - 0.057 13.6 0.0 0.19 12.0 0.0 1.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 EMC82242.1 - 0.071 13.6 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding FAD_binding_2 PF00890.24 EMC82242.1 - 0.12 11.5 0.0 0.21 10.7 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain UDPG_MGDP_dh_N PF03721.14 EMC82242.1 - 0.12 11.9 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Thi4 PF01946.17 EMC82242.1 - 0.15 11.3 0.2 0.23 10.7 0.2 1.2 1 0 0 1 1 1 0 Thi4 family Sugar_tr PF00083.24 EMC82243.1 - 4.2e-22 78.6 22.5 9.8e-22 77.4 22.5 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMC82243.1 - 1.4e-20 73.6 25.2 1.4e-20 73.6 25.2 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Pkinase PF00069.25 EMC82244.1 - 1e-55 189.0 0.0 1e-55 189.0 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC82244.1 - 1.2e-20 73.9 0.0 2.1e-20 73.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMC82244.1 - 0.0026 17.1 0.1 0.0056 16.1 0.1 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMC82244.1 - 0.024 14.5 0.2 0.024 14.5 0.2 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family API5 PF05918.11 EMC82244.1 - 4.4 6.0 9.0 0.084 11.7 2.5 1.4 2 0 0 2 2 2 0 Apoptosis inhibitory protein 5 (API5) SAM_decarbox PF01536.16 EMC82245.1 - 7.8e-112 373.8 2.7 8.8e-112 373.6 2.7 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase TFIIIC_sub6 PF10419.9 EMC82246.1 - 1.1e-16 60.5 0.1 2e-16 59.6 0.1 1.4 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain Brix PF04427.18 EMC82247.1 - 4.6e-45 154.1 0.2 8.5e-45 153.2 0.1 1.5 1 1 0 1 1 1 1 Brix domain MFS_1 PF07690.16 EMC82248.1 - 1.6e-31 109.5 35.0 3.9e-17 62.2 19.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EMC82248.1 - 2.2e-06 27.2 3.9 2.8e-06 26.9 3.9 1.2 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB SEFIR PF08357.11 EMC82250.1 - 4.1e-33 114.8 0.2 5.4e-33 114.4 0.2 1.1 1 0 0 1 1 1 1 SEFIR domain TIR_2 PF13676.6 EMC82250.1 - 3.3e-05 24.5 0.0 5.2e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 TIR domain Pkinase_Tyr PF07714.17 EMC82252.1 - 3.4e-93 311.7 0.0 4.3e-93 311.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC82252.1 - 5.4e-47 160.4 0.0 7.6e-47 159.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 EMC82252.1 - 5.9e-29 100.0 0.3 1.3e-28 98.9 0.3 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 EMC82252.1 - 1.1e-20 72.9 0.3 6.2e-20 70.5 0.1 2.2 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EMC82252.1 - 2.3e-13 49.8 0.4 5.7e-13 48.5 0.1 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EMC82252.1 - 7.7e-12 44.7 0.0 3e-11 42.8 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_10 PF17902.1 EMC82252.1 - 0.015 15.3 0.0 0.032 14.3 0.0 1.5 1 0 0 1 1 1 0 SH3 domain Haspin_kinase PF12330.8 EMC82252.1 - 0.036 13.0 0.0 0.1 11.5 0.0 1.7 1 1 0 1 1 1 0 Haspin like kinase domain SH3_3 PF08239.11 EMC82252.1 - 0.045 14.0 0.1 0.099 12.9 0.1 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain zf-RING_14 PF17978.1 EMC82252.1 - 0.083 13.3 0.1 0.42 11.1 0.0 2.2 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain IGFBP PF00219.18 EMC82253.1 - 1e-10 42.1 21.1 1e-10 42.1 21.1 4.0 3 2 1 4 4 4 1 Insulin-like growth factor binding protein Cys_knot PF00007.22 EMC82253.1 - 3.3e-05 24.1 10.2 3.3e-05 24.1 10.2 3.4 2 1 1 3 3 3 1 Cystine-knot domain VWC PF00093.18 EMC82253.1 - 7.7e-05 22.9 0.3 7.7e-05 22.9 0.3 4.8 4 2 0 4 4 4 1 von Willebrand factor type C domain Laminin_G_2 PF02210.24 EMC82254.1 - 5.9e-96 317.7 0.1 6.1e-23 81.8 0.1 5.5 5 0 0 5 5 5 5 Laminin G domain Laminin_G_1 PF00054.23 EMC82254.1 - 3.8e-78 260.1 0.0 2.4e-21 76.3 0.0 5.5 5 0 0 5 5 5 5 Laminin G domain Laminin_I PF06008.14 EMC82254.1 - 2.2e-33 116.0 31.2 2.2e-33 116.0 31.2 3.7 2 2 2 4 4 4 1 Laminin Domain I Laminin_II PF06009.12 EMC82254.1 - 1.4e-32 112.6 3.8 1.4e-32 112.6 3.8 5.5 2 1 3 5 5 5 2 Laminin Domain II Laminin_EGF PF00053.24 EMC82254.1 - 7.7e-22 77.2 67.9 6.9e-11 42.1 10.4 4.8 4 1 1 5 5 5 3 Laminin EGF domain Laminin_G_3 PF13385.6 EMC82254.1 - 2.8e-18 66.5 0.0 8.4e-08 32.5 0.0 5.2 5 0 0 5 5 5 2 Concanavalin A-like lectin/glucanases superfamily BAG6 PF12057.8 EMC82254.1 - 0.025 14.2 0.6 0.067 12.9 0.6 1.7 1 0 0 1 1 1 0 BCL2-associated athanogene 6 Sec34 PF04136.15 EMC82254.1 - 7.4 6.4 21.0 0.27 11.1 1.0 4.2 2 2 3 5 5 5 0 Sec34-like family Hist_deacetyl PF00850.19 EMC82256.1 - 8e-86 288.3 0.1 1.1e-85 287.8 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Sulfotransfer_1 PF00685.27 EMC82257.1 - 5.6e-35 121.1 0.2 7.2e-35 120.8 0.2 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC82257.1 - 1.9e-10 41.5 0.0 1.2e-05 25.8 0.0 2.2 1 1 1 2 2 2 2 Sulfotransferase family Sulfotransfer_2 PF03567.14 EMC82257.1 - 0.0041 17.1 0.2 0.0064 16.4 0.2 1.3 1 0 0 1 1 1 1 Sulfotransferase family Peptidase_S8 PF00082.22 EMC82258.1 - 3.2e-97 325.4 1.3 4.7e-97 324.8 1.3 1.3 1 0 0 1 1 1 1 Subtilase family TPPII PF12580.8 EMC82258.1 - 5.6e-80 267.3 0.0 1e-79 266.5 0.0 1.4 1 0 0 1 1 1 1 Tripeptidyl peptidase II TPPII_N PF12583.8 EMC82258.1 - 0.0005 20.7 0.2 0.0011 19.6 0.2 1.5 1 0 0 1 1 1 1 Tripeptidyl peptidase II N terminal Methyltransf_16 PF10294.9 EMC82259.1 - 8.6e-32 110.2 0.0 1.3e-31 109.7 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EMC82259.1 - 1.1e-08 35.1 0.0 1.6e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EMC82259.1 - 1e-06 28.4 0.0 1.5e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 EMC82259.1 - 2.3e-06 28.2 0.0 4.2e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC82259.1 - 5.2e-06 27.1 0.0 1.2e-05 26.0 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC82259.1 - 1.9e-05 25.3 0.0 4e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC82259.1 - 0.0028 17.5 0.0 0.0076 16.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_PK PF05891.12 EMC82259.1 - 0.0047 16.5 0.1 0.0093 15.5 0.0 1.5 2 0 0 2 2 2 1 AdoMet dependent proline di-methyltransferase MTS PF05175.14 EMC82259.1 - 0.013 15.1 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain DUF938 PF06080.12 EMC82259.1 - 0.027 14.2 0.0 0.043 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) TehB PF03848.14 EMC82259.1 - 0.03 13.7 0.0 0.061 12.7 0.0 1.5 1 1 0 1 1 1 0 Tellurite resistance protein TehB Hydrolase_4 PF12146.8 EMC82260.1 - 3.3e-06 26.5 0.0 0.071 12.4 0.0 2.5 1 1 1 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 EMC82260.1 - 0.00041 20.0 0.0 0.0014 18.2 0.0 1.8 2 1 0 2 2 2 1 Dienelactone hydrolase family FSH1 PF03959.13 EMC82260.1 - 0.0047 16.6 0.0 0.0069 16.1 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 EMC82260.1 - 0.017 15.8 0.0 0.3 11.7 0.0 2.0 1 1 1 2 2 2 0 Alpha/beta hydrolase family PGAP1 PF07819.13 EMC82260.1 - 0.028 14.1 0.0 1.4 8.6 0.0 2.5 2 1 0 2 2 2 0 PGAP1-like protein Abhydrolase_5 PF12695.7 EMC82260.1 - 0.039 13.7 0.0 0.053 13.3 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF900 PF05990.12 EMC82260.1 - 0.14 11.6 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) XPG_N PF00752.17 EMC82261.1 - 8.9e-32 109.6 0.0 2.4e-31 108.2 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EMC82261.1 - 4e-25 88.0 0.0 2.9e-24 85.2 0.0 2.7 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 EMC82261.1 - 0.0014 19.2 0.0 0.013 16.1 0.0 2.7 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold Yippee-Mis18 PF03226.14 EMC82261.1 - 0.039 14.2 0.0 1.1 9.5 0.0 2.8 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Methyltransf_16 PF10294.9 EMC82262.1 - 1.5e-33 116.0 0.0 1.8e-33 115.7 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EMC82262.1 - 1.5e-06 28.1 0.0 2e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EMC82262.1 - 0.00063 19.2 0.0 0.0008 18.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EMC82262.1 - 0.15 12.8 0.0 0.29 11.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain SBF PF01758.16 EMC82263.1 - 8.3e-46 156.1 17.3 1.7e-45 155.1 17.3 1.5 1 0 0 1 1 1 1 Sodium Bile acid symporter family Biopterin_H PF00351.21 EMC82265.1 - 3e-175 582.0 0.1 3.7e-175 581.7 0.1 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.25 EMC82265.1 - 2.7e-05 23.9 0.1 9.8e-05 22.0 0.0 1.9 2 0 0 2 2 2 1 ACT domain Peptidase_M1 PF01433.20 EMC82266.1 - 1.1e-80 270.4 0.9 1.8e-80 269.6 0.9 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 EMC82266.1 - 2e-76 257.6 3.1 3.5e-76 256.7 3.1 1.4 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EMC82266.1 - 1e-28 100.8 0.3 1.8e-28 100.0 0.3 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain EF-hand_7 PF13499.6 EMC82267.1 - 5.8e-08 33.1 0.5 0.00025 21.4 0.2 3.3 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EMC82267.1 - 6.3e-07 28.8 4.2 0.041 13.8 0.3 4.7 5 0 0 5 5 5 2 EF-hand domain DUF1126 PF06565.12 EMC82267.1 - 4.8e-05 23.1 0.1 0.00011 22.0 0.1 1.5 1 0 0 1 1 1 1 DUF1126 PH-like domain EF-hand_1 PF00036.32 EMC82267.1 - 0.012 15.2 6.1 0.22 11.1 0.2 4.3 5 0 0 5 5 5 0 EF hand EF-hand_5 PF13202.6 EMC82267.1 - 0.025 14.1 0.1 0.095 12.2 0.1 2.1 1 0 0 1 1 1 0 EF hand CAP PF00188.26 EMC82268.1 - 2e-18 67.4 2.5 3.1e-18 66.8 2.5 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family CAP PF00188.26 EMC82269.1 - 2e-23 83.6 4.0 2.7e-23 83.2 4.0 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family ATP-grasp_6 PF18419.1 EMC82269.1 - 0.21 11.2 0.0 0.38 10.4 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp-like domain CAP PF00188.26 EMC82270.1 - 9.6e-26 91.1 1.1 1.4e-25 90.5 1.1 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family KH_8 PF17903.1 EMC82271.1 - 1.7e-29 101.7 0.0 1.7e-29 101.7 0.0 2.6 3 0 0 3 3 3 1 Krr1 KH1 domain KH_1 PF00013.29 EMC82271.1 - 8.2e-05 22.4 0.3 0.0016 18.2 0.0 2.5 2 0 0 2 2 2 1 KH domain KH_4 PF13083.6 EMC82271.1 - 0.039 13.8 0.0 0.12 12.3 0.0 1.8 1 0 0 1 1 1 0 KH domain PIN_4 PF13638.6 EMC82272.1 - 0.055 13.8 0.5 0.11 12.8 0.0 1.6 2 0 0 2 2 2 0 PIN domain NAP PF00956.18 EMC82273.1 - 8.1e-114 379.3 6.5 8.1e-114 379.3 6.5 1.6 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) sCache_3_3 PF17202.4 EMC82273.1 - 0.069 13.6 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 Single cache domain 3 Cpn60_TCP1 PF00118.24 EMC82274.1 - 1.1e-10 40.8 0.0 0.00022 20.0 0.0 2.3 2 0 0 2 2 2 2 TCP-1/cpn60 chaperonin family Oxysterol_BP PF01237.18 EMC82275.1 - 5.2e-95 318.4 3.9 1.4e-92 310.4 3.9 2.5 1 1 0 1 1 1 1 Oxysterol-binding protein PH PF00169.29 EMC82275.1 - 3e-10 40.5 0.0 1.2e-09 38.6 0.0 2.1 1 0 0 1 1 1 1 PH domain DHHC PF01529.20 EMC82276.1 - 1.8e-35 122.0 20.9 1.8e-35 122.0 20.9 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ank_4 PF13637.6 EMC82276.1 - 2.6e-32 110.8 6.1 8e-09 35.9 0.0 4.5 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC82276.1 - 8.3e-31 106.4 0.2 3.6e-16 59.5 0.2 2.7 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC82276.1 - 7e-29 99.5 2.1 6.5e-07 29.5 0.2 5.4 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC82276.1 - 1e-28 96.1 1.5 4.5e-05 23.5 0.1 7.5 8 0 0 8 8 8 5 Ankyrin repeat Ank PF00023.30 EMC82276.1 - 2.3e-23 81.5 2.3 5.6e-06 26.6 0.4 6.0 6 0 0 6 6 6 5 Ankyrin repeat LIM PF00412.22 EMC82277.1 - 2e-30 104.8 27.3 2.9e-17 62.6 5.5 2.1 2 0 0 2 2 2 2 LIM domain DUF4428 PF14471.6 EMC82277.1 - 0.0057 16.6 8.3 0.038 13.9 0.8 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4428) zf_UBZ PF18439.1 EMC82277.1 - 0.093 12.3 12.7 0.39 10.4 0.5 4.1 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf-C2H2_12 PF18658.1 EMC82277.1 - 1.3 8.7 6.2 3.2 7.4 0.9 2.8 3 0 0 3 3 3 0 Zinc-finger C2H2-type E2F_TDP PF02319.20 EMC82278.1 - 1.3e-42 143.7 1.5 9.5e-21 73.6 0.0 2.5 2 0 0 2 2 2 2 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.19 EMC82278.1 - 0.00014 21.7 0.0 0.0012 18.6 0.0 2.3 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB B-block_TFIIIC PF04182.12 EMC82278.1 - 0.0012 18.9 0.0 0.74 10.0 0.0 2.4 2 0 0 2 2 2 2 B-block binding subunit of TFIIIC Cdc6_C PF09079.11 EMC82278.1 - 0.077 13.0 0.0 6 6.9 0.0 2.4 2 0 0 2 2 2 0 CDC6, C terminal winged helix domain NACHT PF05729.12 EMC82280.1 - 3.4e-33 114.9 0.0 8.3e-33 113.7 0.0 1.7 1 0 0 1 1 1 1 NACHT domain NLRC4_HD2 PF17776.1 EMC82280.1 - 1.9e-23 83.4 1.0 2.8e-22 79.6 0.8 2.8 3 0 0 3 3 3 1 NLRC4 helical domain HD2 NOD2_WH PF17779.1 EMC82280.1 - 1.7e-15 57.0 0.0 9.1e-15 54.7 0.0 2.3 2 0 0 2 2 2 1 NOD2 winged helix domain PYRIN PF02758.16 EMC82280.1 - 3.3e-14 52.8 0.0 4.1e-13 49.3 0.0 2.8 3 0 0 3 3 3 1 PAAD/DAPIN/Pyrin domain AAA_16 PF13191.6 EMC82280.1 - 0.00058 20.3 0.0 0.004 17.6 0.0 2.3 3 0 0 3 3 3 1 AAA ATPase domain AAA PF00004.29 EMC82280.1 - 0.012 16.0 0.0 0.031 14.7 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EMC82280.1 - 0.015 15.6 0.0 0.043 14.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain FISNA PF14484.6 EMC82280.1 - 0.024 14.9 0.0 0.052 13.8 0.0 1.6 1 0 0 1 1 1 0 Fish-specific NACHT associated domain AAA_19 PF13245.6 EMC82280.1 - 0.04 14.3 0.0 0.092 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain IBV_3A PF03617.13 EMC82280.1 - 0.045 13.7 0.0 0.096 12.7 0.0 1.5 1 0 0 1 1 1 0 IBV 3A protein Zeta_toxin PF06414.12 EMC82280.1 - 0.13 11.5 1.1 0.21 10.9 0.1 1.8 2 0 0 2 2 2 0 Zeta toxin CEND1 PF15677.5 EMC82281.1 - 4.7e-47 160.2 14.5 5.3e-47 160.1 14.5 1.0 1 0 0 1 1 1 1 Cell cycle exit and neuronal differentiation protein 1 TYW3 PF02676.14 EMC82281.1 - 0.11 11.9 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase TYW3 Alpha_GJ PF03229.13 EMC82281.1 - 0.74 10.4 6.8 0.18 12.4 3.2 1.7 1 1 1 2 2 2 0 Alphavirus glycoprotein J DJ-1_PfpI PF01965.24 EMC82282.1 - 0.0007 19.4 0.0 0.00086 19.1 0.0 1.3 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 EMC82282.1 - 0.019 14.7 0.0 0.023 14.4 0.0 1.3 1 1 0 1 1 1 0 ThiJ/PfpI family-like BTRD1 PF17660.1 EMC82282.1 - 0.075 12.9 0.0 4.6 7.1 0.0 2.5 2 0 0 2 2 2 0 Bacterial tandem repeat domain 1 PTB PF08416.13 EMC82283.1 - 5e-47 159.3 3.5 9.7e-47 158.4 3.5 1.5 1 0 0 1 1 1 1 Phosphotyrosine-binding domain SAM_3 PF18016.1 EMC82283.1 - 1.3e-25 89.0 0.1 2.8e-25 87.9 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_1 PF00018.28 EMC82283.1 - 1.8e-10 40.3 0.1 5e-10 38.8 0.1 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC82283.1 - 5.4e-08 32.6 0.0 1.2e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PID PF00640.23 EMC82283.1 - 5e-06 26.6 3.2 5e-06 26.6 0.8 2.1 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) SH3_2 PF07653.17 EMC82283.1 - 1.4e-05 24.6 0.0 2.8e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 EMC82283.1 - 0.05 13.9 0.1 0.14 12.5 0.1 1.7 1 0 0 1 1 1 0 Bacterial SH3 domain SAM_PNT PF02198.16 EMC82283.1 - 0.1 12.6 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Transmemb_17 PF09799.9 EMC82284.1 - 6e-33 113.6 9.8 6.9e-33 113.4 9.8 1.1 1 0 0 1 1 1 1 Predicted membrane protein SAND PF01342.21 EMC82285.1 - 2.5e-26 91.2 0.3 7.4e-26 89.7 0.0 2.0 2 0 0 2 2 2 1 SAND domain zf-MYND PF01753.18 EMC82285.1 - 6.4e-10 39.0 15.7 6.4e-10 39.0 15.7 2.0 2 0 0 2 2 2 1 MYND finger DUF4858 PF16150.5 EMC82285.1 - 0.34 10.9 1.1 14 5.6 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4858) 7tm_1 PF00001.21 EMC82286.1 - 3.5e-69 233.1 4.6 4e-69 232.9 4.6 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC82286.1 - 1.4e-11 44.3 8.1 3.6e-05 23.3 5.6 2.0 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC82286.1 - 0.00025 20.9 6.9 0.0023 17.7 1.5 2.1 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC82286.1 - 0.0021 17.7 5.2 0.0021 17.7 5.2 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Hormone_2 PF00123.20 EMC82287.1 - 4.6e-22 77.6 0.1 3.3e-12 46.1 0.0 2.4 2 0 0 2 2 2 2 Peptide hormone Cadherin PF00028.17 EMC82288.1 - 7.6e-22 77.6 6.2 7.2e-10 39.2 0.1 4.7 4 1 0 4 4 4 3 Cadherin domain Cadherin_3 PF16184.5 EMC82288.1 - 0.0098 15.9 1.6 0.14 12.1 0.2 3.2 2 1 0 2 2 2 1 Cadherin-like Mad3_BUB1_I PF08311.12 EMC82289.1 - 4.4e-46 155.9 0.3 4.4e-46 155.9 0.3 1.8 2 0 0 2 2 2 1 Mad3/BUB1 homology region 1 Pkinase PF00069.25 EMC82289.1 - 0.00024 20.6 0.0 0.00024 20.6 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain MerR-DNA-bind PF09278.11 EMC82289.1 - 0.012 16.2 2.4 0.012 16.2 2.4 2.3 2 0 0 2 2 2 0 MerR, DNA binding Syntaxin PF00804.25 EMC82289.1 - 0.093 12.4 12.5 1.2 8.8 5.6 2.4 2 0 0 2 2 2 0 Syntaxin Matrilin_ccoil PF10393.9 EMC82289.1 - 0.18 11.7 5.3 0.56 10.1 5.3 1.9 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin Lectin_N PF03954.14 EMC82289.1 - 0.19 11.5 2.5 0.78 9.5 2.5 2.0 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain GARP PF16731.5 EMC82289.1 - 0.2 11.3 6.9 0.44 10.2 6.9 1.5 1 0 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma K_oxygenase PF13434.6 EMC82289.1 - 2.1 7.4 5.5 3.6 6.6 5.5 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Lipoprotein_20 PF13942.6 EMC82289.1 - 8.7 6.2 12.7 5.9 6.8 6.0 3.0 3 0 0 3 3 3 0 YfhG lipoprotein Pkinase PF00069.25 EMC82290.1 - 9.8e-67 225.1 0.0 1.3e-66 224.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC82290.1 - 5.2e-45 153.8 0.0 7.3e-45 153.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EMC82290.1 - 6.1e-16 58.5 0.1 1.6e-15 57.2 0.1 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 EMC82290.1 - 8.3e-07 28.6 0.0 1.2e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMC82290.1 - 0.00018 20.4 0.0 0.0003 19.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EMC82290.1 - 0.16 11.3 0.1 0.26 10.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PI-PLC-X PF00388.19 EMC82291.1 - 7.4e-59 197.5 0.0 3.5e-58 195.3 0.0 2.2 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PLC-beta_C PF08703.10 EMC82291.1 - 1.6e-52 178.1 31.0 1.6e-52 178.1 31.0 2.5 2 0 0 2 2 2 1 PLC-beta C terminal PH_14 PF17787.1 EMC82291.1 - 4.6e-48 162.4 0.0 1.1e-47 161.2 0.0 1.7 1 0 0 1 1 1 1 PH domain PI-PLC-Y PF00387.19 EMC82291.1 - 2.7e-39 134.1 1.7 2.7e-39 134.1 1.7 2.5 3 1 0 3 3 3 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.11 EMC82291.1 - 1.1e-08 35.4 0.0 5.6e-08 33.2 0.0 2.3 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.30 EMC82291.1 - 5.6e-07 29.8 0.0 1.2e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 C2 domain DUF1154 PF06631.11 EMC82291.1 - 2.6e-06 27.3 6.9 2.6e-06 27.3 6.9 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1154) DUF4594 PF15266.6 EMC82293.1 - 7.2e-06 26.5 0.4 7.2e-06 26.5 0.4 2.9 2 1 1 3 3 3 1 Domain of unknown function (DUF4594) S4_2 PF13275.6 EMC82293.1 - 0.098 12.5 0.2 0.17 11.7 0.2 1.3 1 0 0 1 1 1 0 S4 domain Patched PF02460.18 EMC82294.1 - 0.00096 17.4 3.5 0.00096 17.4 3.5 2.4 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 EMC82294.1 - 2.4 8.0 30.5 0.035 14.0 13.7 2.7 2 0 0 2 2 2 0 Sterol-sensing domain of SREBP cleavage-activation Sec61_beta PF03911.16 EMC82294.1 - 5.5 7.1 8.0 7 6.8 1.9 3.3 2 0 0 2 2 2 0 Sec61beta family DUF3975 PF13126.6 EMC82294.1 - 7.1 7.1 10.7 1.3 9.5 4.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3975) HAUS5 PF14817.6 EMC82296.1 - 0.0013 17.6 9.3 0.0015 17.4 9.3 1.0 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 5 Bacillus_HBL PF05791.11 EMC82296.1 - 0.02 14.7 0.4 0.02 14.7 0.4 2.2 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF1043 PF06295.12 EMC82296.1 - 0.032 14.2 12.7 0.052 13.6 3.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) Spc7 PF08317.11 EMC82296.1 - 0.16 10.8 22.1 0.23 10.3 22.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF745 PF05335.13 EMC82296.1 - 0.38 10.5 13.8 1.9 8.2 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF745) KfrA_N PF11740.8 EMC82296.1 - 0.44 11.2 13.2 3.3 8.4 0.5 2.4 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term TnpV PF14198.6 EMC82296.1 - 0.77 9.8 11.8 2.1 8.3 3.7 2.2 2 0 0 2 2 2 0 Transposon-encoded protein TnpV TPR_MLP1_2 PF07926.12 EMC82296.1 - 1.6 8.8 25.3 0.048 13.7 2.5 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Phage_GP20 PF06810.11 EMC82296.1 - 4.5 7.1 18.3 0.038 13.8 2.8 2.3 1 1 1 2 2 2 0 Phage minor structural protein GP20 Acyl-CoA_dh_1 PF00441.24 EMC82297.1 - 5.1e-38 130.6 0.1 7.7e-38 130.1 0.1 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EMC82297.1 - 2.1e-33 115.3 0.0 3.6e-33 114.6 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EMC82297.1 - 1.2e-25 89.5 0.0 2.1e-25 88.7 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EMC82297.1 - 3e-10 40.5 0.0 4.7e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain BAH PF01426.18 EMC82298.1 - 8.5e-15 54.7 0.0 3.4e-14 52.7 0.0 1.9 1 1 0 1 1 1 1 BAH domain Sulfotransfer_2 PF03567.14 EMC82299.1 - 0.039 13.9 0.0 0.041 13.8 0.0 1.0 1 0 0 1 1 1 0 Sulfotransferase family PCP_red PF08369.10 EMC82299.1 - 0.19 12.0 0.2 0.61 10.4 0.1 1.8 1 1 1 2 2 2 0 Proto-chlorophyllide reductase 57 kD subunit 7tm_1 PF00001.21 EMC82300.1 - 2.9e-43 148.1 24.9 3.3e-43 147.9 24.9 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC82300.1 - 3e-13 49.8 23.7 3.5e-13 49.5 23.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx UL17 PF17640.2 EMC82300.1 - 0.052 13.6 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized UL17 7TM_GPCR_Srx PF10328.9 EMC82300.1 - 0.63 9.6 22.1 0.023 14.3 15.5 1.9 3 0 0 3 3 3 0 Serpentine type 7TM GPCR chemoreceptor Srx CCDC32 PF14989.6 EMC82301.1 - 4.9e-37 127.3 0.0 5.7e-37 127.1 0.0 1.1 1 0 0 1 1 1 1 Coiled-coil domain containing 32 PCMT PF01135.19 EMC82302.1 - 6.4e-34 117.5 0.0 6.5e-34 117.5 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EMC82302.1 - 4.6e-05 23.2 0.0 5.8e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.10 EMC82302.1 - 0.00077 19.2 0.0 0.00084 19.1 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_25 PF13649.6 EMC82302.1 - 0.0068 17.1 0.0 0.01 16.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EMC82302.1 - 0.007 16.4 0.0 0.0083 16.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EMC82302.1 - 0.023 14.3 0.0 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.18 EMC82302.1 - 0.027 13.8 0.0 0.031 13.6 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family PrmA PF06325.13 EMC82302.1 - 0.037 13.4 0.0 0.043 13.2 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 EMC82302.1 - 0.057 13.3 0.0 0.069 13.0 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 EMC82302.1 - 0.082 13.6 0.0 0.11 13.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 EMC82302.1 - 0.11 12.0 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase MetW PF07021.12 EMC82302.1 - 0.11 12.0 0.0 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Rhabdo_M1 PF03342.13 EMC82302.1 - 0.17 11.2 0.0 0.19 11.1 0.0 1.1 1 0 0 1 1 1 0 Rhabdovirus M1 matrix protein (M1 polymerase-associated protein) Rad51 PF08423.11 EMC82304.1 - 4.3e-130 432.5 0.0 5.1e-130 432.2 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 EMC82304.1 - 3e-11 43.2 0.0 4.4e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 EMC82304.1 - 2.8e-09 36.9 0.1 4.3e-09 36.2 0.1 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.6 EMC82304.1 - 5.9e-09 36.4 0.2 2.4e-08 34.5 0.3 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain ATPase PF06745.13 EMC82304.1 - 1.9e-05 24.1 1.2 0.00014 21.3 1.2 2.2 1 1 0 1 1 1 1 KaiC HHH PF00633.23 EMC82304.1 - 0.017 15.0 0.1 0.039 13.8 0.1 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif AAA_22 PF13401.6 EMC82304.1 - 0.02 15.2 0.0 0.044 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EMC82304.1 - 0.062 13.0 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain ssDNA_TraI_N PF18272.1 EMC82304.1 - 0.087 12.8 0.2 0.18 11.8 0.2 1.5 1 0 0 1 1 1 0 single-stranded DNA binding TraI N-terminal subdomain TPR_17 PF13431.6 EMC82305.1 - 0.003 17.8 0.1 0.096 13.1 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMC82305.1 - 0.0054 16.4 0.0 0.029 14.1 0.0 2.2 2 0 0 2 2 2 1 TPR repeat TolA_bind_tri PF16331.5 EMC82305.1 - 0.018 15.1 0.1 0.058 13.5 0.1 1.9 1 0 0 1 1 1 0 TolA binding protein trimerisation TPR_2 PF07719.17 EMC82305.1 - 7.9 6.9 8.0 68 4.0 0.2 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat GFRP PF06399.13 EMC82306.1 - 6.4e-35 118.9 0.0 6.9e-35 118.8 0.0 1.0 1 0 0 1 1 1 1 GTP cyclohydrolase I feedback regulatory protein (GFRP) BORG_CEP PF14957.6 EMC82307.1 - 2.4e-05 25.5 0.7 4.2e-05 24.7 0.7 1.6 1 1 0 1 1 1 1 Cdc42 effector Ribosomal_L21p PF00829.21 EMC82309.1 - 1.1e-24 86.6 0.3 1.6e-24 86.0 0.1 1.3 2 0 0 2 2 2 1 Ribosomal prokaryotic L21 protein C2 PF00168.30 EMC82310.1 - 2.8e-20 72.5 0.0 9.8e-15 54.7 0.0 2.4 2 0 0 2 2 2 2 C2 domain Anoctamin PF04547.12 EMC82312.1 - 2.1e-80 270.7 0.0 9e-59 199.5 1.7 2.1 1 1 1 2 2 2 2 Calcium-activated chloride channel NQR2_RnfD_RnfE PF03116.15 EMC82312.1 - 0.12 11.8 7.1 0.057 12.8 3.2 2.2 2 0 0 2 2 2 0 NQR2, RnfD, RnfE family DUF3040 PF11239.8 EMC82312.1 - 1.8 8.9 9.1 3 8.2 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) TIR PF01582.20 EMC82313.1 - 4e-18 65.8 0.0 5.5e-18 65.4 0.0 1.1 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.6 EMC82313.1 - 4.4e-08 33.7 0.0 1.5e-07 32.0 0.0 1.9 1 1 0 1 1 1 1 TIR domain Ig_3 PF13927.6 EMC82313.1 - 2.5e-05 24.8 0.1 5.4e-05 23.7 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC82313.1 - 0.12 12.6 0.1 0.22 11.7 0.1 1.5 1 0 0 1 1 1 0 Immunoglobulin domain Arm PF00514.23 EMC82314.1 - 5.8e-19 67.4 2.4 7.6e-06 25.8 0.0 6.0 7 0 0 7 7 7 4 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EMC82314.1 - 0.0029 18.1 0.2 0.21 12.1 0.0 3.5 4 0 0 4 4 4 1 HEAT-like repeat Atx10homo_assoc PF09759.9 EMC82314.1 - 0.0063 16.5 0.6 0.51 10.4 0.1 3.2 3 0 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain HEAT_2 PF13646.6 EMC82314.1 - 0.095 13.1 0.0 0.43 11.0 0.0 2.2 1 1 0 1 1 1 0 HEAT repeats CD225 PF04505.12 EMC82315.1 - 4.3e-10 39.6 0.0 8.6e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 Interferon-induced transmembrane protein Glyco_hydro_65m PF03632.15 EMC82317.1 - 4.7e-58 196.9 0.0 1e-51 176.0 1.7 2.1 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain COX8 PF02285.15 EMC82318.1 - 3.7e-13 49.1 0.3 4.1e-13 49.0 0.3 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIII Ric8 PF10165.9 EMC82319.1 - 1.3e-125 420.0 5.2 9.2e-105 351.3 0.6 2.8 2 1 1 3 3 3 2 Guanine nucleotide exchange factor synembryn Uteroglobin PF01099.17 EMC82321.1 - 3.4e-10 40.1 0.0 3.8e-10 40.0 0.0 1.0 1 0 0 1 1 1 1 Uteroglobin family DUF3944 PF13099.6 EMC82321.1 - 0.064 13.1 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3944) SieB PF14163.6 EMC82322.1 - 0.0046 16.5 0.0 0.0054 16.2 0.0 1.1 1 0 0 1 1 1 1 Super-infection exclusion protein B LRRCT PF01463.24 EMC82322.1 - 0.006 17.0 0.2 0.012 16.1 0.2 1.5 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain 7tm_1 PF00001.21 EMC82323.1 - 9e-49 166.2 12.2 1.6e-30 106.3 4.1 2.1 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC82323.1 - 1.8e-06 27.9 0.8 2.9e-06 27.2 0.8 1.4 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC82323.1 - 0.00039 20.1 0.2 0.001 18.8 0.2 1.7 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 EMC82323.1 - 0.022 14.1 1.0 0.022 14.1 1.0 2.0 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srv Tankyrase_bdg_C PF15327.6 EMC82324.1 - 3.5e-32 112.2 5.9 4e-32 112.0 5.9 1.0 1 0 0 1 1 1 1 Tankyrase binding protein C terminal domain POB3_N PF17292.2 EMC82325.1 - 3.4e-29 101.1 0.5 1.8e-25 89.1 0.2 2.8 2 0 0 2 2 2 2 POB3-like N-terminal PH domain Rtt106 PF08512.12 EMC82325.1 - 4.7e-28 97.4 0.1 5.6e-27 94.0 0.1 2.6 2 0 0 2 2 2 1 Histone chaperone Rttp106-like SSrecog PF03531.14 EMC82325.1 - 5.9e-28 96.6 0.0 1.5e-27 95.2 0.0 1.8 1 0 0 1 1 1 1 Structure-specific recognition protein (SSRP1) HMG_box PF00505.19 EMC82325.1 - 6.1e-24 84.2 5.2 6.1e-24 84.2 5.2 2.7 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC82325.1 - 7.9e-13 48.8 4.9 7.9e-13 48.8 4.9 2.4 2 0 0 2 2 2 1 HMG-box domain P2X_receptor PF00864.19 EMC82326.1 - 5e-64 216.7 0.0 1.5e-48 165.8 0.0 2.0 2 0 0 2 2 2 2 ATP P2X receptor MFS_1 PF07690.16 EMC82327.1 - 0.0055 15.7 37.2 0.009 15.0 19.7 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily LRR_8 PF13855.6 EMC82328.1 - 5.2e-44 147.8 29.5 4.4e-13 48.8 4.6 3.5 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EMC82328.1 - 4.1e-19 68.4 2.0 0.00023 21.5 0.1 4.1 3 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC82328.1 - 1.3e-08 34.5 0.4 0.00064 19.3 0.1 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_5 PF13306.6 EMC82328.1 - 2.6e-06 27.4 0.0 3.5e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EMC82328.1 - 8.5e-05 22.6 11.5 1.6 9.6 0.0 5.4 5 2 0 5 5 5 2 Leucine Rich Repeat zf-Tim10_DDP PF02953.15 EMC82329.1 - 4.8e-17 61.3 0.4 6.6e-17 60.9 0.4 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger UQ_con PF00179.26 EMC82330.1 - 6.3e-23 81.0 0.1 7.4e-23 80.7 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EMC82330.1 - 0.00087 19.0 0.1 0.0011 18.6 0.1 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B DHHC PF01529.20 EMC82332.1 - 2.2e-16 60.2 9.2 3.5e-14 53.0 3.6 2.7 2 1 1 3 3 3 2 DHHC palmitoyltransferase Thioredoxin PF00085.20 EMC82333.1 - 6.6e-11 42.1 0.0 1.2e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin DUF5020 PF16412.5 EMC82333.1 - 0.099 12.5 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5020) Sigma_reg_C PF13791.6 EMC82334.1 - 0.02 15.1 2.0 0.025 14.8 2.0 1.2 1 0 0 1 1 1 0 Sigma factor regulator C-terminal UPF0449 PF15136.6 EMC82334.1 - 3.1 8.3 13.5 9.3 6.8 13.4 1.7 1 1 0 1 1 1 0 Uncharacterised protein family UPF0449 Arm-DNA-bind_5 PF17293.2 EMC82334.1 - 9.4 6.8 10.4 2.2 8.8 4.5 2.0 1 1 1 2 2 2 0 Arm DNA-binding domain SRCR PF00530.18 EMC82335.1 - 4.3e-26 91.3 4.4 6.6e-26 90.7 4.4 1.3 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 EMC82335.1 - 0.00047 20.6 2.1 0.00064 20.2 2.1 1.4 1 1 0 1 1 1 1 Scavenger receptor cysteine-rich domain DIM PF08194.12 EMC82335.1 - 0.0081 16.3 1.9 0.24 11.6 1.9 2.3 2 0 0 2 2 2 1 DIM protein UbiA PF01040.18 EMC82335.1 - 0.072 12.4 0.6 0.098 11.9 0.6 1.2 1 0 0 1 1 1 0 UbiA prenyltransferase family CTP_synth_N PF06418.14 EMC82336.1 - 1.2e-108 362.5 0.2 2e-108 361.8 0.2 1.4 1 1 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 EMC82336.1 - 1.4e-56 191.3 0.0 2.2e-56 190.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EMC82336.1 - 2.2e-09 37.4 0.0 5.6e-09 36.1 0.0 1.7 1 0 0 1 1 1 1 Peptidase C26 CbiA PF01656.23 EMC82336.1 - 0.0053 16.8 0.0 0.008 16.2 0.1 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain S_100 PF01023.19 EMC82337.1 - 3.3e-07 29.9 0.3 7.1e-07 28.8 0.3 1.6 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.32 EMC82337.1 - 3.4e-07 29.3 0.6 3.4e-07 29.3 0.6 2.1 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 EMC82337.1 - 1.8e-05 25.1 0.7 3.5e-05 24.2 0.1 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EMC82337.1 - 2.8e-05 23.7 1.3 6.6e-05 22.5 0.2 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 EMC82337.1 - 0.00018 21.3 0.4 0.0011 18.7 0.2 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 EMC82337.1 - 0.00026 20.4 1.2 0.00039 19.8 0.1 1.8 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.7 EMC82337.1 - 0.0059 16.5 0.1 0.01 15.8 0.1 1.4 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand Toprim_2 PF13155.6 EMC82337.1 - 0.012 16.0 0.0 0.024 15.0 0.0 1.5 1 0 0 1 1 1 0 Toprim-like DUF3381 PF11861.8 EMC82337.1 - 0.087 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Taxilin PF09728.9 EMC82338.1 - 1.2e-117 392.6 76.4 1.2e-117 392.6 76.4 2.2 1 1 1 2 2 2 1 Myosin-like coiled-coil protein STOP PF05217.12 EMC82338.1 - 0.11 12.8 0.5 0.5 10.7 0.5 2.2 1 0 0 1 1 1 0 STOP protein RFamide_26RFa PF11109.8 EMC82338.1 - 1.3 9.6 11.9 0.21 12.1 0.6 2.9 2 1 0 2 2 2 0 Orexigenic neuropeptide Qrfp/P518 DUF4145 PF13643.6 EMC82338.1 - 1.6 8.9 14.7 13 6.0 4.3 4.5 3 2 0 3 3 3 0 Domain of unknown function (DUF4145) CAF1C_H4-bd PF12265.8 EMC82339.1 - 3e-27 94.7 1.2 2.6e-26 91.7 0.4 2.6 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EMC82339.1 - 1.6e-26 92.0 15.8 3.1e-07 31.0 0.0 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC82339.1 - 1.3e-05 25.4 0.8 0.0053 17.0 0.0 3.5 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC82339.1 - 8.4e-05 22.5 0.3 0.017 15.0 0.0 2.9 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Capsid_NCLDV PF04451.12 EMC82339.1 - 0.089 12.6 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 Large eukaryotic DNA virus major capsid protein BEN PF10523.9 EMC82340.1 - 1.8e-23 82.6 0.1 7.5e-11 42.1 0.0 2.4 2 0 0 2 2 2 2 BEN domain DUF1647 PF07801.11 EMC82340.1 - 0.1 12.4 0.0 17 5.2 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) Collagen PF01391.18 EMC82343.1 - 6.1e-16 57.9 59.9 3.4e-09 36.3 25.2 2.3 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) COE1_HLH PF16423.5 EMC82345.1 - 5.4e-36 122.0 3.0 3.4e-29 100.3 0.4 2.4 2 0 0 2 2 2 2 Transcription factor COE1 helix-loop-helix domain COE1_DBD PF16422.5 EMC82345.1 - 3.8e-33 114.9 2.7 5.4e-33 114.4 2.7 1.2 1 0 0 1 1 1 1 Transcription factor COE1 DNA-binding domain TIG PF01833.24 EMC82345.1 - 6.1e-13 48.6 0.1 6.1e-13 48.6 0.1 2.2 3 0 0 3 3 3 1 IPT/TIG domain Lactamase_B PF00753.27 EMC82346.1 - 2e-17 63.8 7.8 7.2e-16 58.8 7.8 2.0 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EMC82346.1 - 0.0053 16.3 0.4 0.016 14.7 0.4 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain DUF4128 PF13554.6 EMC82347.1 - 0.012 15.7 0.0 0.017 15.2 0.0 1.2 1 0 0 1 1 1 0 Bacteriophage related domain of unknown function RANK_CRD_2 PF18278.1 EMC82348.1 - 3.2e-27 94.4 8.7 3.2e-27 94.4 8.7 2.9 3 1 1 4 4 4 1 Receptor activator of the NF-KB cysteine-rich repeat domain 2 TNFR_c6 PF00020.18 EMC82348.1 - 6e-15 55.4 39.5 6e-05 23.4 0.2 4.6 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region AI-2E_transport PF01594.16 EMC82348.1 - 0.0025 17.0 0.0 0.003 16.7 0.0 1.0 1 0 0 1 1 1 1 AI-2E family transporter Tetraspanin PF00335.20 EMC82348.1 - 0.084 12.6 0.0 0.084 12.6 0.0 2.1 2 1 0 2 2 2 0 Tetraspanin family PspB PF06667.12 EMC82348.1 - 0.1 12.6 0.3 0.21 11.7 0.2 1.5 2 0 0 2 2 2 0 Phage shock protein B TssO PF17561.2 EMC82348.1 - 0.14 12.3 0.1 0.2 11.8 0.1 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssO CrgA PF06781.12 EMC82348.1 - 0.14 12.2 0.0 0.26 11.4 0.0 1.3 1 0 0 1 1 1 0 Cell division protein CrgA DUF2207 PF09972.9 EMC82348.1 - 0.25 10.1 0.0 0.33 9.7 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) LRR_8 PF13855.6 EMC82350.1 - 4.9e-37 125.5 45.5 8.7e-09 35.0 0.4 9.4 6 3 3 9 9 9 9 Leucine rich repeat PP2C PF00481.21 EMC82350.1 - 4.3e-33 115.0 0.0 7e-33 114.3 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_4 PF12799.7 EMC82350.1 - 6.4e-28 96.4 53.5 2e-05 24.9 1.4 11.0 8 1 1 11 11 11 10 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EMC82350.1 - 2.3e-09 36.6 39.4 0.71 10.1 1.5 14.4 16 0 0 16 16 16 4 Leucine Rich repeat LRR_1 PF00560.33 EMC82350.1 - 8.5e-07 28.7 49.6 0.85 10.4 0.8 15.9 15 2 0 15 15 15 2 Leucine Rich Repeat PH PF00169.29 EMC82350.1 - 4.4e-06 27.1 0.0 1e-05 25.9 0.0 1.7 1 0 0 1 1 1 1 PH domain adh_short PF00106.25 EMC82352.1 - 1.1e-54 184.8 0.0 1.5e-54 184.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC82352.1 - 8.6e-31 107.3 0.0 1.1e-30 106.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC82352.1 - 1.2e-13 51.3 0.0 1.7e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EMC82352.1 - 0.0011 18.9 0.0 0.0023 17.8 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EMC82352.1 - 0.0018 18.6 0.1 0.0032 17.7 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DUF1776 PF08643.10 EMC82352.1 - 0.043 13.2 0.0 0.067 12.5 0.0 1.4 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) ApbA PF02558.16 EMC82352.1 - 0.098 12.3 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA AAA PF00004.29 EMC82353.1 - 8.1e-42 142.8 0.0 2e-41 141.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EMC82353.1 - 4.1e-30 103.6 0.3 1.2e-29 102.1 0.3 1.8 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 EMC82353.1 - 4.2e-24 84.4 6.6 1.1e-23 83.0 6.6 1.8 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 EMC82353.1 - 7.6e-09 35.2 0.0 3.7e-08 33.1 0.0 2.2 2 0 0 2 2 2 1 AAA+ lid domain IstB_IS21 PF01695.17 EMC82353.1 - 1.3e-05 25.0 0.0 2.6e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 EMC82353.1 - 1.4e-05 24.5 0.0 2.5e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 EMC82353.1 - 1.9e-05 25.0 0.1 0.01 16.1 0.0 2.7 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 EMC82353.1 - 1.9e-05 24.5 0.0 4.3e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EMC82353.1 - 2.2e-05 24.9 0.2 0.0041 17.5 0.0 2.7 2 1 0 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EMC82353.1 - 6.7e-05 22.9 0.0 0.00019 21.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EMC82353.1 - 7.2e-05 22.8 0.0 0.00017 21.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMC82353.1 - 0.00027 21.5 0.0 0.00085 19.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EMC82353.1 - 0.00047 20.3 0.0 0.003 17.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 EMC82353.1 - 0.00058 19.1 0.0 0.0012 18.1 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF815) AAA_25 PF13481.6 EMC82353.1 - 0.0016 18.1 0.1 1.3 8.5 0.1 2.3 1 1 1 2 2 2 2 AAA domain AAA_33 PF13671.6 EMC82353.1 - 0.0019 18.4 0.0 0.0091 16.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EMC82353.1 - 0.0027 18.0 0.0 0.024 15.0 0.0 2.3 2 0 0 2 2 2 1 RNA helicase ATPase PF06745.13 EMC82353.1 - 0.0068 15.8 0.1 1.5 8.1 0.0 2.3 1 1 0 2 2 2 1 KaiC AAA_24 PF13479.6 EMC82353.1 - 0.01 15.5 0.0 0.024 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EMC82353.1 - 0.012 15.0 0.1 0.032 13.7 0.1 1.7 1 1 0 1 1 1 0 PhoH-like protein TniB PF05621.11 EMC82353.1 - 0.025 14.0 0.0 3.8 6.9 0.0 2.4 1 1 0 2 2 2 0 Bacterial TniB protein Tae4 PF14113.6 EMC82353.1 - 0.026 14.7 0.1 0.059 13.6 0.1 1.5 1 0 0 1 1 1 0 Type VI secretion system (T6SS), amidase effector protein 4 AAA_7 PF12775.7 EMC82353.1 - 0.027 14.0 0.0 0.071 12.6 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 EMC82353.1 - 0.029 14.3 0.0 0.3 11.0 0.0 2.4 2 1 1 3 3 2 0 NACHT domain Mg_chelatase PF01078.21 EMC82353.1 - 0.035 13.5 0.0 0.071 12.5 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EMC82353.1 - 0.063 13.0 0.0 0.27 10.9 0.0 2.1 1 1 0 1 1 1 0 Sigma-54 interaction domain MMR_HSR1 PF01926.23 EMC82353.1 - 0.073 13.2 0.2 5.8 7.0 0.0 3.2 3 0 0 3 3 3 0 50S ribosome-binding GTPase USP8_dimer PF08969.11 EMC82353.1 - 0.1 12.8 4.6 0.22 11.7 4.6 1.6 1 0 0 1 1 1 0 USP8 dimerisation domain MCM PF00493.23 EMC82353.1 - 0.15 11.1 0.0 0.28 10.2 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain Serpin PF00079.20 EMC82354.1 - 1.1e-101 340.8 6.8 1.3e-101 340.6 6.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Toprim_Crpt PF13342.6 EMC82354.1 - 0.029 14.4 1.5 0.56 10.2 0.2 3.1 3 0 0 3 3 3 0 C-terminal repeat of topoisomerase Serpin PF00079.20 EMC82355.1 - 9e-123 410.2 1.3 1e-122 410.0 1.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) PC_rep PF01851.22 EMC82355.1 - 0.13 12.7 0.0 0.44 11.1 0.0 1.9 1 0 0 1 1 1 0 Proteasome/cyclosome repeat Serpin PF00079.20 EMC82356.1 - 3.2e-126 421.6 0.1 3.6e-126 421.4 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 EMC82357.1 - 1.1e-122 410.0 0.6 1.2e-122 409.8 0.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Sec-ASP3 PF15432.6 EMC82357.1 - 0.028 14.6 0.0 0.082 13.1 0.0 1.8 1 0 0 1 1 1 0 Accessory Sec secretory system ASP3 Serpin PF00079.20 EMC82358.1 - 4.1e-124 414.7 1.8 4.6e-124 414.5 1.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Methyltransf_15 PF09445.10 EMC82358.1 - 0.089 12.4 0.0 0.48 10.0 0.0 2.1 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase Serpin PF00079.20 EMC82359.1 - 1.7e-118 396.2 0.7 1.9e-118 396.0 0.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RRF PF01765.19 EMC82359.1 - 0.031 14.2 0.0 0.075 13.0 0.0 1.6 1 0 0 1 1 1 0 Ribosome recycling factor Serpin PF00079.20 EMC82360.1 - 5.7e-133 443.8 1.9 6.5e-133 443.6 1.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 EMC82361.1 - 2.7e-126 421.8 3.5 3.1e-126 421.6 3.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 EMC82362.1 - 2.7e-128 428.4 5.1 3.1e-128 428.2 5.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) WcbI PF18588.1 EMC82362.1 - 0.12 12.0 0.0 2.3 7.8 0.0 2.5 3 0 0 3 3 3 0 Polysaccharide biosynthesis enzyme WcbI Serpin PF00079.20 EMC82363.1 - 1.1e-133 446.2 0.7 1.2e-133 446.0 0.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 EMC82364.1 - 1.9e-26 93.2 0.0 2.3e-26 93.0 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 EMC82365.1 - 2e-29 103.1 0.2 2.1e-29 103.0 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) 7tm_4 PF13853.6 EMC82366.1 - 8.8e-33 114.2 8.9 1.2e-32 113.8 8.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC82366.1 - 1.5e-23 83.4 3.2 2.3e-23 82.8 3.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC82366.1 - 9.3e-06 25.2 6.4 1.2e-05 24.8 6.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC82366.1 - 0.0054 16.4 10.7 0.0072 16.0 10.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Ndc80_HEC PF03801.13 EMC82367.1 - 2.1e-46 157.3 0.0 6.2e-46 155.8 0.0 1.8 1 0 0 1 1 1 1 HEC/Ndc80p family DUF5595 PF18077.1 EMC82367.1 - 1.3e-31 108.5 2.9 1.3e-31 108.5 2.9 6.4 5 1 2 7 7 7 1 Domain of unknown function (DUF5595) Importin_rep_6 PF18829.1 EMC82367.1 - 0.029 14.5 4.0 0.045 13.9 1.4 2.6 1 1 1 2 2 2 0 Importin repeat 6 HrpB7 PF09486.10 EMC82367.1 - 1.2 9.5 23.0 0.2 12.0 1.0 4.1 3 1 1 4 4 4 0 Bacterial type III secretion protein (HrpB7) DUF4407 PF14362.6 EMC82367.1 - 2.2 7.6 22.8 0.076 12.3 5.6 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) LPP PF04728.13 EMC82367.1 - 2.4 8.6 7.6 2.2 8.7 0.1 3.9 4 0 0 4 4 4 0 Lipoprotein leucine-zipper TPR_MLP1_2 PF07926.12 EMC82367.1 - 8.4 6.5 48.0 0.75 9.9 12.8 4.6 2 2 2 4 4 4 0 TPR/MLP1/MLP2-like protein PRAP PF15314.6 EMC82367.1 - 9.6 6.8 9.6 0.22 12.0 1.2 2.7 3 0 0 3 3 3 0 Proline-rich acidic protein 1, pregnancy-specific uterine HATPase_c_3 PF13589.6 EMC82368.1 - 7.9e-14 51.7 0.0 1.3e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EMC82368.1 - 0.00058 20.3 0.0 0.00095 19.7 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase EMI PF07546.13 EMC82369.1 - 1.7e-18 67.1 9.5 1.7e-18 67.1 9.5 2.8 3 0 0 3 3 2 1 EMI domain C1q PF00386.21 EMC82369.1 - 3.7e-14 53.0 0.1 2.5e-13 50.4 0.1 2.3 1 1 0 1 1 1 1 C1q domain DUF1664 PF07889.12 EMC82369.1 - 5.7e-10 39.3 20.7 0.00082 19.4 0.1 6.9 3 2 3 6 6 6 4 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 EMC82369.1 - 2.7e-05 24.5 13.7 0.0057 17.1 0.0 6.5 6 1 0 6 6 5 1 Nucleopolyhedrovirus P10 protein BLOC1_2 PF10046.9 EMC82369.1 - 0.0018 18.6 21.9 2.6 8.4 0.0 5.9 4 2 2 6 6 5 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 MscS_porin PF12795.7 EMC82369.1 - 0.0029 17.2 8.8 0.14 11.7 2.7 3.7 3 0 0 3 3 3 1 Mechanosensitive ion channel porin domain DUF3829 PF12889.7 EMC82369.1 - 0.0051 16.3 9.1 2.3 7.6 0.1 4.2 4 0 0 4 4 4 1 Protein of unknown function (DUF3829) DUF5082 PF16888.5 EMC82369.1 - 0.0058 16.9 25.2 0.034 14.4 0.7 5.8 4 2 2 6 6 6 3 Domain of unknown function (DUF5082) Apolipoprotein PF01442.18 EMC82369.1 - 0.007 16.3 12.9 2.1 8.2 5.2 4.4 3 2 0 3 3 3 1 Apolipoprotein A1/A4/E domain Bacillus_HBL PF05791.11 EMC82369.1 - 0.014 15.3 0.2 0.014 15.3 0.2 4.2 3 1 1 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) DUF948 PF06103.11 EMC82369.1 - 0.018 15.3 12.2 9.1 6.6 0.0 6.3 5 1 2 7 7 7 0 Bacterial protein of unknown function (DUF948) TelA PF05816.11 EMC82369.1 - 0.029 13.5 11.7 0.18 10.8 1.9 3.6 2 1 1 3 3 3 0 Toxic anion resistance protein (TelA) OCRE PF17780.1 EMC82369.1 - 0.039 14.0 0.6 0.078 13.0 0.6 1.4 1 0 0 1 1 1 0 OCRE domain BLI1 PF17324.2 EMC82369.1 - 0.084 13.5 1.7 13 6.5 0.7 3.4 2 0 0 2 2 2 0 BLOC-1 interactor 1 Sec8_exocyst PF04048.14 EMC82369.1 - 0.11 12.4 0.1 0.11 12.4 0.1 4.6 4 2 0 4 4 4 0 Sec8 exocyst complex component specific domain YscO PF07321.12 EMC82369.1 - 0.16 11.9 8.1 8.4 6.3 0.5 4.5 4 1 0 4 4 4 0 Type III secretion protein YscO Fez1 PF06818.15 EMC82369.1 - 0.68 10.3 28.8 19 5.6 6.8 4.7 1 1 3 4 4 4 0 Fez1 Spc7 PF08317.11 EMC82369.1 - 0.93 8.3 28.4 0.57 9.0 0.7 4.8 3 2 1 4 4 4 0 Spc7 kinetochore protein DUF4140 PF13600.6 EMC82369.1 - 1.3 9.5 4.8 75 3.9 0.0 4.8 5 1 0 5 5 4 0 N-terminal domain of unknown function (DUF4140) Filament PF00038.21 EMC82369.1 - 1.5 8.3 31.5 4.7 6.7 9.9 4.4 2 2 1 3 3 3 0 Intermediate filament protein HBM PF16591.5 EMC82369.1 - 1.7 8.0 6.4 26 4.1 2.7 3.1 3 0 0 3 3 3 0 Helical bimodular sensor domain Laminin_II PF06009.12 EMC82369.1 - 1.9 8.5 16.1 4.2 7.4 0.2 5.0 4 2 1 5 5 4 0 Laminin Domain II DUF745 PF05335.13 EMC82369.1 - 4.7 6.9 6.7 2.8 7.6 0.3 3.3 2 1 1 4 4 4 0 Protein of unknown function (DUF745) Alpha-2-MRAP_C PF06401.11 EMC82369.1 - 4.8 7.1 16.3 3 7.7 0.0 4.5 2 2 2 4 4 4 0 Alpha-2-macroglobulin RAP, C-terminal domain Collagen PF01391.18 EMC82369.1 - 7.2 6.5 5.4 5.4 6.8 2.8 2.0 2 1 0 2 2 2 0 Collagen triple helix repeat (20 copies) CC2-LZ PF16516.5 EMC82369.1 - 8 6.9 16.0 34 4.9 0.6 4.9 4 2 1 5 5 4 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Spectrin PF00435.21 EMC82369.1 - 8.4 6.9 17.4 7.1 7.2 0.9 5.6 2 2 4 6 6 6 0 Spectrin repeat OmpH PF03938.14 EMC82369.1 - 9.2 6.6 16.5 36 4.7 4.7 4.7 3 2 2 5 5 5 0 Outer membrane protein (OmpH-like) LNS2 PF08235.13 EMC82370.1 - 9.1e-104 345.9 0.0 2.7e-103 344.3 0.0 1.8 2 0 0 2 2 2 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 EMC82370.1 - 7.6e-45 151.0 0.1 1.5e-44 150.1 0.1 1.5 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.5 EMC82370.1 - 2.9e-34 117.2 0.1 1.1e-33 115.3 0.1 2.0 2 0 0 2 2 2 1 Lipin/Ned1/Smp2 multi-domain protein middle domain WRNPLPNID PF15017.6 EMC82370.1 - 0.00055 20.8 0.7 0.00055 20.8 0.7 3.1 3 1 0 3 3 3 1 Putative WW-binding domain and destruction box Tash_PEST PF07708.11 EMC82370.1 - 1.4 9.1 5.9 0.24 11.6 1.3 2.3 2 0 0 2 2 2 0 Tash protein PEST motif fn3 PF00041.21 EMC82371.1 - 5.4e-77 254.2 0.1 2.9e-15 56.4 0.0 5.8 5 0 0 5 5 5 5 Fibronectin type III domain I-set PF07679.16 EMC82371.1 - 4.4e-74 244.6 13.4 2e-21 75.8 0.1 7.8 7 0 0 7 7 7 7 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC82371.1 - 1.5e-46 156.9 6.8 7.4e-11 42.5 0.1 7.4 7 0 0 7 7 7 6 Immunoglobulin domain Ig_2 PF13895.6 EMC82371.1 - 3.8e-36 123.3 5.6 2.5e-09 37.4 0.2 6.8 7 0 0 7 7 7 5 Immunoglobulin domain ig PF00047.25 EMC82371.1 - 1.3e-20 73.4 17.9 0.0058 16.8 0.4 8.4 9 0 0 9 9 9 5 Immunoglobulin domain V-set PF07686.17 EMC82371.1 - 1.1e-14 54.6 25.5 0.094 12.9 0.0 10.3 8 4 1 9 9 9 4 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC82371.1 - 2.5e-10 40.3 0.6 0.0051 16.9 0.0 4.6 4 0 0 4 4 4 3 CD80-like C2-set immunoglobulin domain Tissue_fac PF01108.17 EMC82371.1 - 0.00015 21.6 0.0 2 8.3 0.0 4.7 5 0 0 5 5 5 2 Tissue factor Invasin_D3 PF09134.10 EMC82371.1 - 0.0045 17.3 2.6 20 5.6 0.0 4.9 5 0 0 5 5 5 1 Invasin, domain 3 EF-hand_7 PF13499.6 EMC82372.1 - 9.7e-14 51.6 6.1 1.1e-07 32.2 0.1 2.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 EMC82372.1 - 1.2e-13 49.6 12.0 1.3e-07 30.7 1.6 4.5 6 0 0 6 6 6 3 EF hand EF-hand_6 PF13405.6 EMC82372.1 - 1.8e-11 43.0 9.4 7.6e-08 31.7 0.9 3.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 EMC82372.1 - 3.7e-08 33.1 7.1 0.0025 17.6 0.5 3.7 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 EMC82372.1 - 1.6e-05 24.2 4.2 1.8e-05 24.0 1.5 2.5 2 0 0 2 2 2 1 EF hand EF-hand_11 PF08976.11 EMC82372.1 - 2.1e-05 25.3 0.2 0.00077 20.3 0.1 2.1 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.13 EMC82372.1 - 0.0021 18.0 0.0 1.5 8.9 0.0 2.9 3 0 0 3 3 3 1 Uncharacterised protein family (UPF0154) EF-hand_9 PF14658.6 EMC82372.1 - 0.0024 18.2 0.0 1.5 9.2 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain GPHH PF16905.5 EMC82372.1 - 0.015 15.0 0.0 2.2 8.1 0.0 2.3 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated SurA_N_2 PF13623.6 EMC82372.1 - 0.02 14.8 0.1 2.4 8.0 0.0 2.1 2 0 0 2 2 2 0 SurA N-terminal domain SPARC_Ca_bdg PF10591.9 EMC82372.1 - 0.024 14.9 0.9 0.043 14.1 0.4 1.6 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF2267 PF10025.9 EMC82372.1 - 0.04 14.2 0.0 8.6 6.7 0.0 2.9 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2267) DUF2666 PF10869.8 EMC82372.1 - 0.095 12.9 0.0 0.43 10.8 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2666) DDE_Tnp_IS66_C PF13817.6 EMC82372.1 - 0.13 12.5 0.0 3.2 8.1 0.0 2.6 2 0 0 2 2 2 0 IS66 C-terminal element EF-hand_7 PF13499.6 EMC82373.1 - 9.6e-14 51.6 6.1 1.1e-07 32.2 0.1 2.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 EMC82373.1 - 1.2e-13 49.6 12.0 1.3e-07 30.7 1.6 4.5 6 0 0 6 6 6 3 EF hand EF-hand_6 PF13405.6 EMC82373.1 - 1.8e-11 43.0 9.4 7.6e-08 31.7 0.9 3.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 EMC82373.1 - 3.6e-08 33.1 7.1 0.0025 17.6 0.5 3.7 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 EMC82373.1 - 1.6e-05 24.2 4.2 1.8e-05 24.0 1.5 2.5 2 0 0 2 2 2 1 EF hand EF-hand_11 PF08976.11 EMC82373.1 - 2.1e-05 25.3 0.2 0.00077 20.3 0.1 2.1 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.13 EMC82373.1 - 0.0016 18.4 0.0 1.5 8.9 0.0 3.0 3 0 0 3 3 3 1 Uncharacterised protein family (UPF0154) EF-hand_9 PF14658.6 EMC82373.1 - 0.0024 18.2 0.0 1.5 9.2 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain Syntaxin PF00804.25 EMC82373.1 - 0.011 15.4 0.2 0.31 10.7 0.1 2.0 2 0 0 2 2 2 0 Syntaxin GPHH PF16905.5 EMC82373.1 - 0.016 15.0 0.0 2.2 8.1 0.0 2.3 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated SurA_N_2 PF13623.6 EMC82373.1 - 0.018 14.9 0.1 2.4 8.0 0.0 2.1 2 0 0 2 2 2 0 SurA N-terminal domain SPARC_Ca_bdg PF10591.9 EMC82373.1 - 0.026 14.8 1.1 0.042 14.2 0.5 1.6 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF2267 PF10025.9 EMC82373.1 - 0.047 14.0 0.0 8.6 6.7 0.0 2.8 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2267) DUF2666 PF10869.8 EMC82373.1 - 0.087 13.0 0.0 0.43 10.8 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2666) DDE_Tnp_IS66_C PF13817.6 EMC82373.1 - 0.13 12.5 0.0 3.2 8.1 0.0 2.6 2 0 0 2 2 2 0 IS66 C-terminal element Homeobox_KN PF05920.11 EMC82374.1 - 2.6e-17 62.4 1.0 4.9e-17 61.5 1.0 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EMC82374.1 - 1.1e-07 31.6 1.3 1.8e-07 30.9 1.3 1.3 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 EMC82374.1 - 0.071 12.6 0.5 0.17 11.4 0.1 1.8 1 1 1 2 2 2 0 Homeodomain leucine-zipper encoding, Homez Myc_N PF01056.18 EMC82375.1 - 1.5e-41 143.4 10.4 7e-39 134.7 7.8 2.3 1 1 1 2 2 2 2 Myc amino-terminal region Myc-LZ PF02344.15 EMC82375.1 - 2.6e-17 62.6 12.5 2.6e-17 62.6 12.5 2.2 2 0 0 2 2 2 1 Myc leucine zipper domain HLH PF00010.26 EMC82375.1 - 1.2e-14 54.0 9.8 7.1e-14 51.5 1.0 2.3 2 0 0 2 2 2 2 Helix-loop-helix DNA-binding domain DUF1394 PF07159.12 EMC82376.1 - 2.1e-152 506.6 0.1 2.4e-152 506.5 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) V-ATPase_H_N PF03224.14 EMC82376.1 - 0.018 14.3 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 V-ATPase subunit H ArfGap PF01412.18 EMC82377.1 - 7.2e-36 122.8 0.0 2.1e-35 121.3 0.0 1.9 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 EMC82377.1 - 6.9e-26 91.4 12.8 1.3e-25 90.5 12.8 1.4 1 0 0 1 1 1 1 BAR domain of APPL family Ank_2 PF12796.7 EMC82377.1 - 2.4e-15 56.9 2.0 9.5e-09 35.7 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) PH PF00169.29 EMC82377.1 - 1.6e-10 41.4 0.4 6.3e-10 39.5 0.4 2.1 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.28 EMC82377.1 - 1.1e-09 37.8 0.3 2.2e-09 36.8 0.3 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC82377.1 - 1.4e-09 37.6 0.2 2.9e-09 36.6 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain BAR PF03114.18 EMC82377.1 - 6.4e-09 35.8 7.3 1.2e-08 34.9 7.3 1.4 1 0 0 1 1 1 1 BAR domain Ank PF00023.30 EMC82377.1 - 8.7e-09 35.4 0.4 0.00028 21.2 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat SH3_2 PF07653.17 EMC82377.1 - 5.7e-07 29.1 0.2 1.4e-06 27.9 0.2 1.7 1 0 0 1 1 1 1 Variant SH3 domain Ank_3 PF13606.6 EMC82377.1 - 1.7e-05 24.8 0.5 0.096 13.3 0.0 3.4 3 0 0 3 3 2 2 Ankyrin repeat Ank_4 PF13637.6 EMC82377.1 - 5.1e-05 23.7 0.3 0.00044 20.7 0.3 2.7 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC82377.1 - 0.0034 17.7 0.1 0.047 14.0 0.1 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) STELLO PF03385.17 EMC82377.1 - 0.01 14.6 0.4 2.8 6.6 0.0 3.2 3 0 0 3 3 3 0 STELLO glycosyltransferases PH_3 PF14593.6 EMC82377.1 - 0.041 14.0 0.1 0.15 12.2 0.1 2.0 2 0 0 2 2 1 0 PH domain PH_9 PF15410.6 EMC82377.1 - 0.19 12.1 2.3 5.2 7.5 0.2 3.1 3 1 0 3 3 2 0 Pleckstrin homology domain PAD PF03068.15 EMC82377.1 - 1.1 8.2 3.6 0.72 8.8 1.6 1.6 2 0 0 2 2 2 0 Protein-arginine deiminase (PAD) PRIMA1 PF16101.5 EMC82378.1 - 0.1 12.6 1.8 0.13 12.3 1.8 1.1 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Guanylate_cyc PF00211.20 EMC82379.1 - 4.4e-88 293.7 0.0 3.8e-58 196.1 0.0 2.2 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.5 EMC82379.1 - 3.6e-34 118.6 5.1 3.6e-34 118.6 5.1 2.4 2 0 0 2 2 2 1 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF1053 PF06327.14 EMC82379.1 - 2.6e-28 98.6 0.1 6.8e-28 97.3 0.1 1.8 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1053) TBK1_ULD PF18396.1 EMC82379.1 - 0.0064 16.4 0.2 0.016 15.1 0.2 1.6 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Sec20 PF03908.13 EMC82381.1 - 0.05 13.5 0.3 0.83 9.6 0.0 2.2 2 0 0 2 2 2 0 Sec20 TMEM71 PF15121.6 EMC82382.1 - 1.3e-53 180.7 0.8 1.9e-53 180.1 0.8 1.2 1 0 0 1 1 1 1 TMEM71 protein family COesterase PF00135.28 EMC82383.1 - 6.1e-124 414.7 0.0 8.3e-124 414.2 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Thyroglobulin_1 PF00086.18 EMC82383.1 - 5.8e-91 298.2 73.8 7.9e-14 51.1 2.8 11.6 11 0 0 11 11 11 10 Thyroglobulin type-1 repeat Ephrin_rec_like PF07699.13 EMC82383.1 - 1.4e-11 44.0 6.3 1.4e-11 44.0 6.3 3.2 2 1 1 3 3 3 1 Putative ephrin-receptor like Abhydrolase_3 PF07859.13 EMC82383.1 - 0.0015 18.4 0.1 0.0037 17.1 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold SH2 PF00017.24 EMC82384.1 - 3.1e-21 75.2 0.4 1.1e-20 73.5 0.1 2.0 2 0 0 2 2 2 1 SH2 domain SH3_1 PF00018.28 EMC82384.1 - 5.7e-07 29.0 0.0 1.1e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 SH3 domain IGFBP PF00219.18 EMC82385.1 - 6.5e-11 42.7 21.5 6.5e-11 42.7 21.5 5.0 4 3 0 4 4 4 1 Insulin-like growth factor binding protein Cys_knot PF00007.22 EMC82385.1 - 2.5e-09 37.4 8.1 2.5e-09 37.4 8.1 3.7 4 1 0 4 4 4 1 Cystine-knot domain VWC PF00093.18 EMC82385.1 - 1.8e-08 34.6 12.0 1.8e-08 34.6 12.0 5.2 4 3 0 4 4 4 1 von Willebrand factor type C domain TSP_1 PF00090.19 EMC82385.1 - 5.5e-06 26.5 4.5 5.5e-06 26.5 4.5 3.6 4 0 0 4 4 4 1 Thrombospondin type 1 domain Ndr PF03096.14 EMC82386.1 - 1.3e-124 414.5 0.0 1.5e-124 414.3 0.0 1.0 1 0 0 1 1 1 1 Ndr family Abhydrolase_1 PF00561.20 EMC82386.1 - 0.00074 19.2 0.0 0.037 13.7 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMC82386.1 - 0.015 14.5 0.0 0.025 13.9 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Glyco_transf_29 PF00777.18 EMC82387.1 - 1.3e-79 267.4 0.0 1.7e-79 267.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) PAXNEB PF05625.11 EMC82387.1 - 0.18 10.9 0.0 0.25 10.4 0.0 1.2 1 0 0 1 1 1 0 PAXNEB protein Cytochrome-c551 PF10643.9 EMC82387.1 - 0.2 11.2 0.3 11 5.5 0.0 2.5 2 1 1 3 3 3 0 Photosystem P840 reaction-centre cytochrome c-551 zf-C2H2 PF00096.26 EMC82389.1 - 9.4e-43 142.3 156.8 6.9e-05 23.1 3.3 19.4 19 0 0 19 19 19 17 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC82389.1 - 2e-42 141.7 137.1 1.6e-07 31.4 0.3 21.2 22 1 0 22 22 22 13 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC82389.1 - 1.6e-35 118.7 149.5 0.0053 17.5 2.9 19.4 19 0 0 19 19 19 17 C2H2-type zinc finger zf-H2C2_5 PF13909.6 EMC82389.1 - 1.9e-31 107.4 124.5 2.4e-09 36.7 1.1 15.2 16 1 0 16 16 16 9 C2H2-type zinc-finger domain zf-Di19 PF05605.12 EMC82389.1 - 5.4e-15 55.4 94.5 0.0014 18.8 0.7 12.4 11 1 1 12 12 12 8 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 EMC82389.1 - 9.2e-05 22.7 5.3 9.2e-05 22.7 5.3 15.0 4 2 12 16 16 16 3 C2H2 type zinc-finger (2 copies) Rad50_zn_hook PF04423.14 EMC82389.1 - 0.004 16.9 6.9 0.069 13.0 0.1 4.3 3 0 0 3 3 3 1 Rad50 zinc hook motif zf-met PF12874.7 EMC82389.1 - 0.02 15.3 103.1 0.029 14.8 0.4 14.9 16 0 0 16 16 15 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EMC82389.1 - 0.041 13.9 0.1 0.041 13.9 0.1 14.6 18 0 0 18 18 17 0 C2H2-type zinc finger ARS2 PF04959.13 EMC82389.1 - 0.16 12.3 0.1 0.16 12.3 0.1 5.3 5 0 0 5 5 4 0 Arsenite-resistance protein 2 MNHE PF01899.16 EMC82389.1 - 0.59 9.9 2.1 1.7 8.4 0.5 2.1 1 1 1 2 2 2 0 Na+/H+ ion antiporter subunit Zn-C2H2_12 PF18112.1 EMC82389.1 - 0.93 10.0 26.7 2 8.9 0.3 8.5 9 1 0 9 9 8 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_jaz PF12171.8 EMC82389.1 - 5.5 7.4 119.9 0.084 13.2 0.6 16.7 19 0 0 19 19 17 0 Zinc-finger double-stranded RNA-binding Qua1 PF16274.5 EMC82390.1 - 2e-28 98.0 0.6 2e-28 98.0 0.6 2.1 2 0 0 2 2 2 1 Qua1 domain Sam68-YY PF16568.5 EMC82390.1 - 5.3e-19 68.7 34.5 1.1e-18 67.7 34.5 1.6 1 0 0 1 1 1 1 Tyrosine-rich domain of Sam68 KH_1 PF00013.29 EMC82390.1 - 5.5e-07 29.3 0.0 9.7e-07 28.5 0.0 1.4 1 0 0 1 1 1 1 KH domain STAR_dimer PF16544.5 EMC82390.1 - 0.083 12.5 0.1 0.17 11.5 0.1 1.5 1 0 0 1 1 1 0 Homodimerisation region of STAR domain protein DUF676 PF05057.14 EMC82391.1 - 1.3e-57 194.8 0.0 2.2e-57 194.1 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF3657 PF12394.8 EMC82391.1 - 1.3e-18 67.3 3.0 4.5e-18 65.5 1.1 2.8 2 0 0 2 2 2 1 Protein FAM135 Palm_thioest PF02089.15 EMC82391.1 - 1.2e-07 31.8 0.0 2.9e-07 30.6 0.0 1.6 1 1 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 EMC82391.1 - 1.1e-05 25.3 0.0 2.3e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein LCAT PF02450.15 EMC82391.1 - 0.0064 15.7 0.0 0.013 14.7 0.0 1.4 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase LRR_8 PF13855.6 EMC82392.1 - 5.8e-20 70.8 19.7 1.3e-07 31.3 6.1 3.4 1 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EMC82392.1 - 4.8e-17 61.8 26.3 1.1e-07 32.1 1.2 4.0 3 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC82392.1 - 1.6e-06 27.8 26.3 0.56 11.0 0.1 7.5 7 1 1 8 8 8 4 Leucine Rich Repeat LRR_9 PF14580.6 EMC82392.1 - 8.4e-06 25.4 8.3 0.0011 18.5 1.4 2.8 1 1 2 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.6 EMC82392.1 - 0.14 12.3 0.1 0.14 12.3 0.1 5.7 6 0 0 6 6 6 0 Leucine Rich repeat Pigment_DH PF06324.11 EMC82392.1 - 1 9.6 6.6 2.1 8.6 0.1 3.4 4 0 0 4 4 4 0 Pigment-dispersing hormone (PDH) Ion_trans_2 PF07885.16 EMC82394.1 - 1.3e-36 124.4 20.5 1.7e-18 66.3 8.7 2.8 2 1 1 3 3 3 2 Ion channel Ion_trans PF00520.31 EMC82394.1 - 2.6e-07 30.1 5.9 0.0081 15.4 0.0 2.2 1 1 1 2 2 2 2 Ion transport protein IRK PF01007.20 EMC82394.1 - 0.061 13.1 2.9 0.24 11.2 0.0 2.6 2 1 0 2 2 2 0 Inward rectifier potassium channel transmembrane domain CLTH PF10607.9 EMC82394.1 - 0.078 12.9 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain DUF2254 PF10011.9 EMC82394.1 - 0.64 8.8 1.8 27 3.4 0.1 2.9 3 0 0 3 3 3 0 Predicted membrane protein (DUF2254) MutS_III PF05192.18 EMC82397.1 - 0.23 11.6 0.0 0.32 11.2 0.0 1.1 1 0 0 1 1 1 0 MutS domain III zf-C2H2_3rep PF18868.1 EMC82398.1 - 0.00048 20.8 1.4 0.00048 20.8 1.4 4.2 3 1 3 6 6 6 1 Zinc finger C2H2-type, 3 repeats Homeodomain PF00046.29 EMC82398.1 - 0.0043 16.9 0.0 0.011 15.6 0.0 1.6 1 0 0 1 1 1 1 Homeodomain zf-C2H2_4 PF13894.6 EMC82398.1 - 0.012 16.4 61.8 0.095 13.6 0.7 9.5 9 0 0 9 9 9 0 C2H2-type zinc finger Zn-C2H2_12 PF18112.1 EMC82398.1 - 0.025 15.0 0.3 0.025 15.0 0.3 2.6 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain DUF2719 PF10891.8 EMC82398.1 - 0.03 14.2 3.7 0.94 9.4 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2719) zf_C2H2_ZHX PF18387.1 EMC82398.1 - 0.067 12.8 21.5 1.1 8.9 1.0 5.4 5 0 0 5 5 5 0 Zinc-fingers and homeoboxes C2H2 finger domain PRP21_like_P PF12230.8 EMC82398.1 - 0.4 10.5 3.9 0.78 9.6 0.1 2.8 3 0 0 3 3 3 0 Pre-mRNA splicing factor PRP21 like protein RBFA PF02033.18 EMC82399.1 - 5.3e-12 46.1 0.3 1.8e-11 44.4 0.0 2.0 2 0 0 2 2 2 1 Ribosome-binding factor A RnaseA PF00074.20 EMC82399.1 - 0.43 11.0 3.3 0.18 12.3 0.9 1.6 2 0 0 2 2 2 0 Pancreatic ribonuclease Bac_small_YrzI PF09501.10 EMC82399.1 - 1.6 8.9 6.9 0.88 9.8 3.5 2.4 2 0 0 2 2 2 0 Probable sporulation protein (Bac_small_yrzI) 2-Hacid_dh_C PF02826.19 EMC82400.1 - 5.2e-61 205.1 0.1 6.8e-61 204.7 0.1 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EMC82400.1 - 1.4e-17 63.6 0.0 1.6e-17 63.4 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EMC82400.1 - 9.4e-10 38.9 0.1 1.8e-09 38.0 0.1 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 EMC82400.1 - 0.00029 20.2 0.1 0.00049 19.4 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain GFO_IDH_MocA PF01408.22 EMC82400.1 - 0.0069 17.2 0.0 0.012 16.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold IlvN PF07991.12 EMC82400.1 - 0.038 13.6 0.1 0.057 13.0 0.1 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 EMC82400.1 - 0.046 14.3 0.0 0.1 13.2 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.18 EMC82400.1 - 0.052 13.8 0.1 2.5 8.4 0.0 2.3 2 0 0 2 2 2 0 TrkA-N domain 2-Hacid_dh_C PF02826.19 EMC82401.1 - 1.7e-59 200.2 0.1 2.9e-59 199.4 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EMC82401.1 - 2.3e-22 79.1 0.1 2.8e-22 78.8 0.1 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EMC82401.1 - 5.4e-11 42.9 0.4 1.1e-10 41.8 0.2 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 EMC82401.1 - 8.5e-05 21.9 0.1 0.00017 21.0 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain F420_oxidored PF03807.17 EMC82401.1 - 0.00055 20.5 0.0 0.0014 19.1 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent GFO_IDH_MocA PF01408.22 EMC82401.1 - 0.00059 20.7 0.1 0.0017 19.2 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold AdoHcyase_NAD PF00670.21 EMC82401.1 - 0.0039 17.3 0.5 0.87 9.6 0.1 2.4 2 1 0 2 2 2 2 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AlaDh_PNT_N PF05222.15 EMC82401.1 - 0.0051 17.1 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain IlvN PF07991.12 EMC82401.1 - 0.027 14.1 0.1 0.044 13.4 0.1 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 EMC82401.1 - 0.05 13.7 0.1 0.12 12.5 0.1 1.6 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 EMC82401.1 - 0.25 11.6 2.7 2 8.7 0.0 3.2 4 0 0 4 4 4 0 TrkA-N domain HSBP1 PF06825.12 EMC82402.1 - 2.2e-15 56.2 2.6 5.8e-15 54.9 2.6 1.6 1 1 0 1 1 1 1 Heat shock factor binding protein 1 YvrJ PF12841.7 EMC82402.1 - 0.0083 15.6 1.0 0.12 11.9 0.0 2.1 2 0 0 2 2 2 1 YvrJ protein family Matrilin_ccoil PF10393.9 EMC82402.1 - 0.01 15.7 0.1 0.023 14.6 0.1 1.7 1 1 0 1 1 1 1 Trimeric coiled-coil oligomerisation domain of matrilin DUF1974 PF09317.11 EMC82402.1 - 0.036 13.6 0.0 0.038 13.5 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1974) PQ-loop PF04193.14 EMC82403.1 - 1.1e-30 105.1 8.0 1.6e-19 69.4 0.1 3.7 3 1 1 4 4 4 2 PQ loop repeat ER_lumen_recept PF00810.18 EMC82403.1 - 1.4e-06 29.2 4.4 0.0037 18.1 1.1 2.5 2 1 0 2 2 2 2 ER lumen protein retaining receptor MtN3_slv PF03083.16 EMC82403.1 - 0.042 13.9 9.5 0.058 13.4 2.0 2.9 2 1 1 3 3 3 0 Sugar efflux transporter for intercellular exchange Ion_trans PF00520.31 EMC82404.1 - 9.8e-38 129.8 3.6 1.4e-37 129.3 3.6 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 EMC82404.1 - 7.6e-28 96.7 0.0 1.7e-27 95.6 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 EMC82404.1 - 2.9e-14 52.8 4.5 7.3e-14 51.5 2.3 2.4 2 0 0 2 2 2 1 Ion channel RHD_DNA_bind PF00554.22 EMC82405.1 - 9.2e-26 90.8 0.1 3.3e-25 89.0 0.1 2.0 1 1 0 1 1 1 1 Rel homology DNA-binding domain RHD_dimer PF16179.5 EMC82405.1 - 3e-25 88.2 0.1 5.1e-25 87.5 0.1 1.4 1 0 0 1 1 1 1 Rel homology dimerisation domain TIG PF01833.24 EMC82405.1 - 2.9e-06 27.3 0.1 1.1e-05 25.5 0.0 2.1 2 0 0 2 2 2 1 IPT/TIG domain PhoLip_ATPase_C PF16212.5 EMC82406.1 - 1.5e-52 178.9 19.9 1.5e-52 178.9 19.9 2.3 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EMC82406.1 - 6.9e-20 70.5 1.3 2e-19 69.0 1.3 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EMC82406.1 - 1.1e-14 55.3 0.1 8.9e-12 45.7 0.1 3.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EMC82406.1 - 1.3e-13 50.8 0.0 3.7e-13 49.4 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase PF13246.6 EMC82406.1 - 1e-08 35.1 0.0 6.9e-08 32.5 0.0 2.4 2 1 1 3 3 3 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EMC82406.1 - 0.00064 19.5 0.0 0.0018 18.0 0.0 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF4174 PF13778.6 EMC82406.1 - 0.1 13.1 0.1 0.3 11.6 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) zf-C2H2 PF00096.26 EMC82407.1 - 6.5e-25 86.2 57.6 5.7e-05 23.4 0.2 8.0 8 0 0 8 8 7 7 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC82407.1 - 2e-24 84.8 44.4 4.7e-07 29.9 1.1 9.1 9 0 0 9 9 9 6 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC82407.1 - 1.2e-23 81.8 57.8 0.00069 20.3 1.1 8.6 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC82407.1 - 3.8e-16 58.9 31.5 0.00091 19.4 1.0 8.2 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC82407.1 - 1e-13 51.1 44.1 0.0026 18.1 0.4 8.0 8 0 0 8 8 8 6 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EMC82407.1 - 1.2e-05 25.1 50.3 0.0072 16.3 1.6 8.1 8 0 0 8 8 8 5 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EMC82407.1 - 0.0079 15.9 38.1 0.67 9.8 0.1 7.3 7 0 0 7 7 7 3 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 EMC82407.1 - 0.014 15.8 32.8 0.52 10.7 2.2 7.3 3 3 4 7 7 7 0 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 EMC82407.1 - 0.017 15.4 23.8 0.071 13.4 2.6 4.2 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.5 EMC82407.1 - 0.02 15.2 1.1 0.02 15.2 1.1 4.4 4 1 0 4 4 3 0 C2H2-type zinc ribbon zf-C2H2_3rep PF18868.1 EMC82407.1 - 0.088 13.5 14.0 29 5.3 0.3 5.9 4 1 1 5 5 5 0 Zinc finger C2H2-type, 3 repeats DUF3268 PF11672.8 EMC82407.1 - 0.26 11.6 10.4 0.38 11.1 0.2 3.3 3 0 0 3 3 3 0 zinc-finger-containing domain BolA PF01722.18 EMC82407.1 - 0.27 11.6 4.6 15 5.9 0.1 3.6 3 0 0 3 3 3 0 BolA-like protein DUF2225 PF09986.9 EMC82407.1 - 0.44 10.2 0.0 0.44 10.2 0.0 2.4 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) Elf1 PF05129.13 EMC82407.1 - 1 9.4 19.3 3.8 7.6 0.3 4.6 3 1 1 4 4 4 0 Transcription elongation factor Elf1 like Zn-C2H2_12 PF18112.1 EMC82407.1 - 3.7 8.1 8.7 13 6.4 0.7 4.3 4 0 0 4 4 4 0 Autophagy receptor zinc finger-C2H2 domain UBZ_FAAP20 PF15750.5 EMC82407.1 - 5.6 7.0 7.5 1.8 8.6 0.1 3.8 5 0 0 5 5 4 0 Ubiquitin-binding zinc-finger Drf_FH1 PF06346.12 EMC82410.1 - 1.5e-12 47.5 37.7 2.8e-06 27.1 17.4 2.3 1 1 1 2 2 2 2 Formin Homology Region 1 zf-CCHC_6 PF15288.6 EMC82410.1 - 7.3e-09 35.3 34.8 25 4.8 0.0 11.8 1 1 20 21 21 21 20 Zinc knuckle AKAP95 PF04988.12 EMC82411.1 - 5.5e-69 231.6 7.8 8.7e-69 230.9 7.8 1.2 1 0 0 1 1 1 1 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_2 PF12756.7 EMC82411.1 - 0.00031 21.0 7.0 0.039 14.3 0.2 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) PLATZ PF04640.14 EMC82411.1 - 0.096 13.3 1.4 1.2 9.8 0.0 2.8 2 0 0 2 2 2 0 PLATZ transcription factor Actin_micro PF17003.5 EMC82411.1 - 0.64 9.1 12.1 32 3.5 12.1 2.1 1 1 0 1 1 1 0 Putative actin-like family AKAP95 PF04988.12 EMC82412.1 - 1.4e-74 249.8 6.2 2.8e-74 248.8 6.2 1.5 1 0 0 1 1 1 1 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_2 PF12756.7 EMC82412.1 - 0.23 11.8 5.8 2.8 8.3 0.6 2.4 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 EMC82412.1 - 2 9.0 5.6 0.3 11.5 0.9 2.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type IGFBP PF00219.18 EMC82414.1 - 1.5 9.5 30.0 1.8e+04 -16.0 30.0 4.8 1 1 0 1 1 1 0 Insulin-like growth factor binding protein Mucin-like PF16058.5 EMC82415.1 - 0.0029 17.7 0.0 0.29 11.2 0.0 1.9 1 1 1 2 2 2 2 Mucin-like hEGF PF12661.7 EMC82416.1 - 0.089 13.5 1.8 0.089 13.5 1.8 12.9 13 4 0 13 13 13 0 Human growth factor-like EGF p450 PF00067.22 EMC82417.1 - 2.5e-77 260.6 0.0 3e-77 260.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TetR_C_28 PF17937.1 EMC82417.1 - 0.4 11.1 6.6 1.2 9.6 0.1 3.4 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain SPRR2 PF14820.6 EMC82418.1 - 0.00072 19.6 141.5 10 6.3 12.4 9.5 1 1 7 8 8 8 3 Small proline-rich 2 Retinal PF15449.6 EMC82419.1 - 3.2e-12 45.2 14.8 0.00029 18.8 1.4 3.1 1 1 2 3 3 3 3 Retinal protein Cadherin PF00028.17 EMC82420.1 - 8.7e-77 253.7 10.4 4.6e-19 68.7 0.2 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 EMC82420.1 - 6.7e-59 198.4 0.8 1.5e-58 197.2 0.8 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_3 PF16184.5 EMC82420.1 - 2.7e-07 30.5 7.8 0.19 11.7 0.1 5.5 5 1 0 5 5 5 3 Cadherin-like Cadherin_4 PF17803.1 EMC82420.1 - 3.4e-05 24.4 19.7 0.015 15.9 1.2 4.9 4 0 0 4 4 4 2 Bacterial cadherin-like domain Cadherin_2 PF08266.12 EMC82420.1 - 6.8e-05 22.6 0.0 1.2 9.0 0.0 3.6 3 0 0 3 3 3 2 Cadherin-like ASFV_J13L PF05568.11 EMC82420.1 - 0.0061 16.3 0.0 0.013 15.2 0.0 1.5 1 0 0 1 1 1 1 African swine fever virus J13L protein Stevor PF17410.2 EMC82420.1 - 0.012 15.2 0.0 0.02 14.5 0.0 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Invasin_D3 PF09134.10 EMC82420.1 - 0.014 15.7 4.1 13 6.1 0.0 4.8 4 0 0 4 4 4 0 Invasin, domain 3 Cadherin_pro PF08758.11 EMC82420.1 - 0.018 15.2 0.0 2.6 8.3 0.0 3.0 3 0 0 3 3 3 0 Cadherin prodomain like 7TM_GPCR_Srw PF10324.9 EMC82420.1 - 0.1 11.9 0.1 0.16 11.2 0.1 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw Big_9 PF17963.1 EMC82420.1 - 0.48 11.2 18.8 0.63 10.8 1.0 4.6 5 0 0 5 5 5 0 Bacterial Ig domain Lyase_1 PF00206.20 EMC82421.1 - 6.2e-123 410.1 0.1 8.1e-123 409.8 0.1 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 EMC82421.1 - 1.2e-27 96.1 0.1 6.2e-27 93.8 0.0 2.2 2 0 0 2 2 2 1 Fumarase C C-terminus FAD_binding_2 PF00890.24 EMC82422.1 - 1.1e-126 423.4 2.3 1.3e-126 423.1 2.3 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 EMC82422.1 - 1e-38 132.2 0.0 1.6e-38 131.6 0.0 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 EMC82422.1 - 2.6e-06 26.9 0.3 0.0021 17.3 0.0 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMC82422.1 - 1.8e-05 24.1 0.4 0.11 11.8 0.1 2.4 2 0 0 2 2 2 2 Thi4 family GIDA PF01134.22 EMC82422.1 - 0.00015 21.0 3.9 0.066 12.3 2.2 2.6 3 0 0 3 3 3 2 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EMC82422.1 - 0.0042 16.4 0.1 0.0068 15.7 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EMC82422.1 - 0.049 13.2 0.2 0.12 11.9 0.1 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EMC82422.1 - 0.16 10.6 1.2 0.82 8.3 0.1 2.5 3 0 0 3 3 3 0 HI0933-like protein Pyr_redox_3 PF13738.6 EMC82422.1 - 0.63 9.2 1.8 3.4 6.8 0.5 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase PTS_IIA PF02255.16 EMC82423.1 - 0.084 12.9 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 PTS system, Lactose/Cellobiose specific IIA subunit PIN_3 PF13470.6 EMC82423.1 - 0.75 10.6 3.8 1.8 9.4 3.4 2.0 1 1 0 1 1 1 0 PIN domain Exonuc_VII_L PF02601.15 EMC82423.1 - 0.77 9.3 9.5 0.95 9.0 9.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit HIP1_clath_bdg PF16515.5 EMC82423.1 - 1.5 9.4 16.6 8.9 7.0 13.0 2.4 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 AAA_23 PF13476.6 EMC82423.1 - 4.3 7.8 8.7 7.8 6.9 8.7 1.4 1 0 0 1 1 1 0 AAA domain SNF PF00209.18 EMC82424.1 - 5.7e-177 589.5 32.0 7e-177 589.3 32.0 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family CLPTM1 PF05602.12 EMC82425.1 - 1.7e-128 429.3 2.8 2e-128 429.1 2.8 1.0 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) Acyltransferase PF01553.21 EMC82426.1 - 1.6e-17 63.3 0.0 2.9e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase EF-hand_6 PF13405.6 EMC82426.1 - 2.3e-12 45.8 0.2 0.0045 16.8 0.0 3.8 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 EMC82426.1 - 2.6e-12 46.4 1.4 2.2e-08 33.8 0.0 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EMC82426.1 - 2.8e-10 39.0 0.3 0.0087 15.5 0.1 3.7 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EMC82426.1 - 5.3e-09 36.4 0.1 8e-05 23.0 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EMC82426.1 - 3.6e-05 23.1 0.4 0.16 11.5 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_4 PF12763.7 EMC82426.1 - 0.0089 16.0 0.0 2 8.4 0.0 2.3 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand PrgI PF12666.7 EMC82426.1 - 0.037 14.7 2.0 0.11 13.2 2.0 1.8 1 0 0 1 1 1 0 PrgI family protein zf-CHCC PF10276.9 EMC82428.1 - 2.8e-18 65.7 0.6 3.8e-18 65.2 0.6 1.2 1 0 0 1 1 1 1 Zinc-finger domain Thiolase_C PF02803.18 EMC82428.1 - 0.14 11.8 0.0 0.2 11.3 0.0 1.1 1 0 0 1 1 1 0 Thiolase, C-terminal domain RVT_1 PF00078.27 EMC82429.1 - 0.11 12.0 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Homeobox_KN PF05920.11 EMC82431.1 - 1.2e-15 57.2 0.4 1.2e-15 57.2 0.4 1.9 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 EMC82431.1 - 5.2e-07 29.4 0.4 1e-06 28.5 0.4 1.5 1 0 0 1 1 1 1 Homeodomain Dicty_REP PF05086.12 EMC82431.1 - 0.035 12.1 1.2 0.046 11.7 1.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein MRP-S32 PF10210.9 EMC82431.1 - 0.14 12.7 3.3 0.16 12.5 0.2 2.3 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S32 DUF3729 PF12526.8 EMC82431.1 - 3.1 9.4 15.0 1.7 10.3 2.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3729) FAM176 PF14851.6 EMC82432.1 - 4.4e-55 185.3 0.2 4.9e-55 185.2 0.2 1.0 1 0 0 1 1 1 1 FAM176 family DUF4576 PF15144.6 EMC82432.1 - 0.037 13.9 0.5 0.057 13.3 0.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4576) DUF755 PF05501.11 EMC82432.1 - 1.2 9.5 7.5 1.7 8.9 7.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Gal_Lectin PF02140.18 EMC82433.1 - 1.4e-38 131.2 5.5 6.4e-19 68.2 0.2 2.2 2 0 0 2 2 2 2 Galactose binding lectin domain DUF3395 PF11875.8 EMC82433.1 - 0.0046 16.9 0.0 0.099 12.5 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3395) Ribosomal_L19 PF01245.20 EMC82434.1 - 1e-17 64.0 0.0 1.6e-17 63.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L19 GCFC PF07842.12 EMC82435.1 - 9.8e-27 94.3 3.9 5.1e-26 91.9 3.9 2.1 1 1 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein PH_13 PF16652.5 EMC82436.1 - 6.1e-72 240.5 1.0 6.1e-72 240.5 1.0 3.6 3 1 1 4 4 2 1 Pleckstrin homology domain SH3_9 PF14604.6 EMC82436.1 - 3.2e-66 219.0 3.3 1.1e-15 57.2 0.1 5.4 5 0 0 5 5 5 5 Variant SH3 domain SH3_1 PF00018.28 EMC82436.1 - 8.5e-66 217.4 9.5 8.2e-16 57.3 0.1 5.5 5 0 0 5 5 5 5 SH3 domain SH3_2 PF07653.17 EMC82436.1 - 1.8e-59 197.3 0.4 2.3e-13 49.6 0.1 5.5 5 0 0 5 5 5 5 Variant SH3 domain RhoGEF PF00621.20 EMC82436.1 - 5.6e-43 147.3 0.1 5.6e-43 147.3 0.1 3.3 2 1 0 2 2 1 1 RhoGEF domain EF-hand_4 PF12763.7 EMC82436.1 - 7.4e-26 90.1 0.0 2.1e-13 50.1 0.0 2.7 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand C2 PF00168.30 EMC82436.1 - 2.1e-22 79.4 0.0 5.1e-22 78.1 0.0 1.7 1 0 0 1 1 1 1 C2 domain EF-hand_1 PF00036.32 EMC82436.1 - 1.5e-09 36.7 0.1 0.0046 16.4 0.0 3.5 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EMC82436.1 - 1.1e-07 31.2 0.5 0.63 10.1 0.0 4.1 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 EMC82436.1 - 1.4e-07 31.8 0.6 0.00056 20.3 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain pair PH PF00169.29 EMC82436.1 - 0.00062 20.2 0.1 0.0019 18.7 0.1 1.9 1 0 0 1 1 1 1 PH domain EF-hand_8 PF13833.6 EMC82436.1 - 0.015 15.1 0.0 1.6 8.6 0.0 2.7 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.6 EMC82436.1 - 0.031 13.8 0.9 8.8 6.0 0.1 3.3 3 0 0 3 3 3 0 EF hand INTAP PF16617.5 EMC82436.1 - 0.66 10.4 9.5 0.017 15.5 1.9 2.3 2 0 0 2 2 2 0 Intersectin and clathrin adaptor AP2 binding region ADH_zinc_N PF00107.26 EMC82438.1 - 2.9e-22 79.0 0.1 6.2e-22 78.0 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMC82438.1 - 9.4e-18 65.5 0.0 2.4e-17 64.3 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMC82438.1 - 2.2e-09 37.2 0.1 2e-07 30.9 0.0 2.6 2 1 1 3 3 3 2 Alcohol dehydrogenase GroES-like domain RRM_1 PF00076.22 EMC82439.1 - 1.5e-16 60.0 0.3 1.2e-15 57.0 0.0 2.2 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMC82439.1 - 0.00021 20.9 0.0 0.00026 20.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FKBP_C PF00254.28 EMC82440.1 - 8.6e-32 109.3 0.0 9.4e-32 109.2 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase WDCP PF15390.6 EMC82441.1 - 0 1082.5 0.1 0 1082.3 0.1 1.0 1 0 0 1 1 1 1 WD repeat and coiled-coil-containing protein family ANAPC4_WD40 PF12894.7 EMC82441.1 - 0.034 14.4 0.3 0.19 12.1 0.1 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EMC82441.1 - 0.04 13.9 0.0 0.088 12.8 0.0 1.6 1 0 0 1 1 1 0 WD40-like Beta Propeller Repeat WDCP PF15390.6 EMC82442.1 - 0 1055.6 0.6 0 1055.5 0.6 1.0 1 0 0 1 1 1 1 WD repeat and coiled-coil-containing protein family MFS_2 PF13347.6 EMC82443.1 - 5.7e-106 354.6 18.7 6.4e-106 354.5 18.7 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1 PF07690.16 EMC82443.1 - 6.1e-10 38.5 25.5 2.1e-07 30.2 7.8 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily ATP-synt_8 PF00895.20 EMC82443.1 - 2.7 8.5 5.9 1.7 9.2 0.1 3.3 3 0 0 3 3 3 0 ATP synthase protein 8 SEP PF08059.13 EMC82444.1 - 9.3e-26 90.2 0.7 2.1e-25 89.1 0.2 1.8 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 EMC82444.1 - 2.2e-15 56.6 1.1 4.8e-15 55.5 0.1 2.1 3 0 0 3 3 3 1 UBX domain AAA PF00004.29 EMC82445.1 - 1.8e-47 161.1 0.0 1.2e-40 139.0 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) Bromodomain PF00439.25 EMC82445.1 - 2.3e-17 62.8 0.1 6.4e-17 61.4 0.1 1.7 1 0 0 1 1 1 1 Bromodomain AAA_lid_3 PF17862.1 EMC82445.1 - 3.5e-12 45.9 0.0 1.1e-11 44.3 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EMC82445.1 - 4.1e-08 33.8 0.1 0.00032 21.1 0.0 3.3 3 0 0 3 3 3 2 AAA ATPase domain IstB_IS21 PF01695.17 EMC82445.1 - 7.3e-06 25.8 0.0 3.9e-05 23.4 0.0 2.1 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_2 PF07724.14 EMC82445.1 - 8.1e-05 22.8 0.0 0.00029 21.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EMC82445.1 - 0.00065 20.0 0.5 0.05 13.9 0.1 3.7 3 1 0 3 3 3 1 AAA domain AAA_5 PF07728.14 EMC82445.1 - 0.0052 16.8 0.1 0.059 13.4 0.0 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EMC82445.1 - 0.0056 16.2 0.0 0.25 10.8 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region DUF1088 PF06469.11 EMC82445.1 - 0.01 15.5 1.3 0.024 14.3 1.3 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1088) RNA_helicase PF00910.22 EMC82445.1 - 0.013 15.8 0.0 0.058 13.8 0.0 2.1 2 0 0 2 2 2 0 RNA helicase Sigma54_activ_2 PF14532.6 EMC82445.1 - 0.015 15.4 0.0 1.4 9.0 0.0 2.8 2 1 1 3 3 3 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 EMC82445.1 - 0.015 14.7 0.0 0.23 10.8 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF2075 PF09848.9 EMC82445.1 - 0.016 14.5 0.0 0.032 13.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RuvB_N PF05496.12 EMC82445.1 - 0.026 14.2 0.0 0.11 12.3 0.0 2.1 2 0 0 2 2 1 0 Holliday junction DNA helicase RuvB P-loop domain ResIII PF04851.15 EMC82445.1 - 0.033 14.2 0.0 0.14 12.2 0.0 2.0 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_18 PF13238.6 EMC82445.1 - 0.036 14.6 2.6 0.076 13.6 0.0 2.7 2 1 0 2 2 1 0 AAA domain TIP49 PF06068.13 EMC82445.1 - 0.047 12.9 0.0 0.21 10.8 0.0 1.9 2 0 0 2 2 2 0 TIP49 P-loop domain Sigma54_activat PF00158.26 EMC82445.1 - 0.057 13.1 0.0 0.74 9.5 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain NACHT PF05729.12 EMC82445.1 - 0.11 12.4 0.0 0.65 9.9 0.1 2.3 2 1 0 2 2 2 0 NACHT domain AAA_33 PF13671.6 EMC82445.1 - 0.12 12.6 0.3 0.53 10.4 0.0 2.3 2 0 0 2 2 1 0 AAA domain AAA_25 PF13481.6 EMC82445.1 - 0.14 11.7 0.0 0.34 10.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF4746 PF15928.5 EMC82445.1 - 0.39 10.1 4.7 0.72 9.2 4.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) AAA_11 PF13086.6 EMC82445.1 - 0.42 10.4 0.0 0.42 10.4 0.0 3.2 4 1 0 4 4 2 0 AAA domain DUF4636 PF15468.6 EMC82445.1 - 1.7 8.3 6.1 6.8 6.3 5.7 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4636) Rnk_N PF14760.6 EMC82446.1 - 0.011 16.2 0.5 4.7 7.8 0.0 2.6 1 1 1 2 2 2 0 Rnk N-terminus Kelch_1 PF01344.25 EMC82447.1 - 2.2e-44 148.8 12.8 2.4e-12 46.2 0.0 6.4 7 0 0 7 7 7 5 Kelch motif Kelch_6 PF13964.6 EMC82447.1 - 2.2e-44 148.3 6.5 2e-09 37.4 0.0 6.4 2 1 4 6 6 6 6 Kelch motif BACK PF07707.15 EMC82447.1 - 1.8e-30 105.1 0.2 1.8e-30 105.1 0.2 1.6 2 0 0 2 2 1 1 BTB And C-terminal Kelch Kelch_4 PF13418.6 EMC82447.1 - 3.6e-25 87.7 2.5 1.2e-07 31.6 0.0 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain BTB PF00651.31 EMC82447.1 - 8.9e-24 83.9 0.9 2.3e-23 82.5 0.9 1.7 1 0 0 1 1 1 1 BTB/POZ domain Kelch_2 PF07646.15 EMC82447.1 - 2.3e-22 78.0 1.5 7.4e-05 22.6 0.0 6.9 7 1 0 7 7 7 4 Kelch motif Kelch_3 PF13415.6 EMC82447.1 - 1.8e-14 53.6 2.5 0.002 18.4 0.0 5.7 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC82447.1 - 1.2e-12 47.5 18.8 0.0049 16.8 0.1 6.5 7 0 0 7 7 7 4 Kelch motif DUF3342 PF11822.8 EMC82447.1 - 0.022 14.9 0.2 0.17 12.1 0.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF3342) DUF1668 PF07893.13 EMC82447.1 - 0.026 13.9 0.0 0.59 9.4 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1668) PQQ_3 PF13570.6 EMC82447.1 - 0.049 14.1 4.4 16 6.1 0.1 4.2 4 0 0 4 4 4 0 PQQ-like domain IGPS PF00218.21 EMC82447.1 - 0.06 12.5 0.4 0.18 11.0 0.1 1.8 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase LIDHydrolase PF10230.9 EMC82449.1 - 2.4e-85 286.3 0.0 2.8e-85 286.1 0.0 1.1 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Ser_hydrolase PF06821.13 EMC82449.1 - 0.001 19.0 0.0 0.0057 16.5 0.0 2.0 2 0 0 2 2 2 1 Serine hydrolase Abhydrolase_6 PF12697.7 EMC82449.1 - 0.0015 19.2 0.0 0.0018 18.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMC82449.1 - 0.0062 15.8 0.0 0.011 15.0 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 EMC82449.1 - 0.033 13.1 0.0 0.089 11.7 0.0 1.7 1 1 0 1 1 1 0 Chlorophyllase enzyme Abhydrolase_1 PF00561.20 EMC82449.1 - 0.063 12.9 0.0 0.17 11.5 0.0 1.6 2 0 0 2 2 2 0 alpha/beta hydrolase fold DUF900 PF05990.12 EMC82449.1 - 0.065 12.7 0.1 0.16 11.4 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) LCAT PF02450.15 EMC82449.1 - 0.16 11.1 0.5 0.3 10.2 0.1 1.6 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase TGF_beta PF00019.20 EMC82450.1 - 6.6e-34 117.0 0.5 9.6e-34 116.5 0.5 1.2 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 EMC82450.1 - 2.5e-12 47.1 0.0 3.1e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide PX PF00787.24 EMC82451.1 - 1.6e-12 47.4 1.6 3.6e-12 46.3 0.1 2.1 2 0 0 2 2 2 1 PX domain CAF1A PF12253.8 EMC82452.1 - 0.18 12.0 0.0 0.3 11.3 0.0 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A WD40 PF00400.32 EMC82453.1 - 5.4e-32 109.3 14.5 1.8e-06 28.5 0.0 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC82453.1 - 3e-11 43.5 1.7 0.58 10.5 0.0 5.5 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC82453.1 - 9.4e-06 25.6 3.3 0.042 13.7 0.7 2.9 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Collagen PF01391.18 EMC82453.1 - 0.00012 21.7 26.5 0.00012 21.7 26.5 9.4 5 1 3 8 8 8 2 Collagen triple helix repeat (20 copies) Ge1_WD40 PF16529.5 EMC82453.1 - 0.00065 18.8 0.0 0.012 14.6 0.1 2.5 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein RNA_pol_Rpb4 PF03874.16 EMC82454.1 - 1.3e-26 93.3 5.6 1.5e-26 93.1 5.6 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 Rop PF01815.16 EMC82454.1 - 0.0076 16.1 0.8 0.015 15.2 0.2 1.8 2 0 0 2 2 2 1 Rop protein Maelstrom PF13017.6 EMC82454.1 - 0.08 12.6 0.4 0.092 12.4 0.4 1.1 1 0 0 1 1 1 0 piRNA pathway germ-plasm component AMMECR1 PF01871.17 EMC82455.1 - 1e-47 161.8 0.0 1.3e-47 161.5 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 SAP130_C PF16014.5 EMC82456.1 - 5.9e-225 746.9 18.6 5.9e-225 746.9 18.6 5.1 2 1 2 5 5 5 1 Histone deacetylase complex subunit SAP130 C-terminus DNA_pol3_delta PF06144.13 EMC82456.1 - 0.073 12.8 1.7 0.12 12.2 1.7 1.3 1 0 0 1 1 1 0 DNA polymerase III, delta subunit Glyco_transf_24 PF18404.1 EMC82458.1 - 3.9e-148 492.1 5.8 5.4e-148 491.6 4.0 2.1 2 0 0 2 2 2 1 Glucosyltransferase 24 Thioredoxin_15 PF18403.1 EMC82458.1 - 1.8e-71 240.5 3.2 5.3e-65 219.3 0.8 3.4 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_14 PF18402.1 EMC82458.1 - 4.3e-68 230.0 11.4 1e-63 215.7 1.6 3.7 4 0 0 4 4 4 3 Thioredoxin-like domain Thioredoxin_12 PF18400.1 EMC82458.1 - 5.6e-55 186.2 0.5 2.2e-53 181.0 0.5 2.5 2 0 0 2 2 2 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 EMC82458.1 - 6.5e-40 135.6 0.0 1.9e-39 134.2 0.0 1.9 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_13 PF18401.1 EMC82458.1 - 1.1e-37 129.0 2.1 4.9e-37 126.9 0.2 3.0 3 0 0 3 3 3 1 Thioredoxin-like domain Glyco_transf_8 PF01501.20 EMC82458.1 - 3.5e-05 23.5 3.9 0.00023 20.8 0.4 3.3 3 0 0 3 3 3 1 Glycosyl transferase family 8 Sulfotransfer_2 PF03567.14 EMC82459.1 - 1.7e-48 165.8 0.5 2.3e-48 165.3 0.5 1.2 1 0 0 1 1 1 1 Sulfotransferase family NuA4 PF09340.10 EMC82459.1 - 0.51 10.3 2.7 1.3 9.0 2.7 1.6 1 0 0 1 1 1 0 Histone acetyltransferase subunit NuA4 PH PF00169.29 EMC82460.1 - 1.1e-10 42.0 0.3 1.4e-10 41.6 0.3 1.2 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EMC82460.1 - 0.0019 18.6 0.4 0.0052 17.2 0.4 1.7 1 1 0 1 1 1 1 Pleckstrin homology domain TCRP1 PF14944.6 EMC82461.1 - 1.4e-108 362.5 66.0 4.7e-87 292.0 44.1 2.0 1 1 1 2 2 2 2 Tongue Cancer Chemotherapy Resistant Protein 1 RhoGEF PF00621.20 EMC82462.1 - 7.1e-47 160.0 6.6 7.1e-47 160.0 6.6 2.1 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 EMC82462.1 - 7.6e-11 42.5 0.7 1.7e-10 41.3 0.7 1.6 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.28 EMC82462.1 - 3e-10 39.5 1.9 5.5e-10 38.7 1.9 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC82462.1 - 2.9e-09 36.7 0.1 5.4e-09 35.8 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC82462.1 - 1.1e-07 31.5 0.0 2e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH_5 PF15405.6 EMC82462.1 - 0.045 13.8 0.1 0.65 10.1 0.0 2.3 1 1 1 2 2 2 0 Pleckstrin homology domain DUF5348 PF17295.2 EMC82462.1 - 0.082 12.8 0.2 3.5 7.6 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5348) DUF3104 PF11302.8 EMC82462.1 - 0.21 11.3 0.6 0.49 10.2 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) Cor1 PF04803.12 EMC82462.1 - 1.8 8.8 10.4 0.68 10.2 0.9 3.2 3 1 1 4 4 4 0 Cor1/Xlr/Xmr conserved region G-alpha PF00503.20 EMC82465.1 - 7.2e-92 308.3 2.1 8e-92 308.1 2.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EMC82465.1 - 7.4e-12 45.1 0.2 2.7e-11 43.2 0.2 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EMC82466.1 - 1.2e-108 363.5 3.9 1.3e-108 363.3 3.9 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EMC82466.1 - 1.2e-12 47.6 3.2 5.8e-11 42.2 0.1 2.7 3 1 0 3 3 3 2 ADP-ribosylation factor family SPT16 PF08644.11 EMC82466.1 - 0.035 14.3 0.4 0.058 13.6 0.4 1.3 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) ATP_bind_1 PF03029.17 EMC82466.1 - 4.9 6.9 6.5 7 6.3 0.9 2.8 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein Collagen PF01391.18 EMC82468.1 - 2e-42 142.8 211.8 1.2e-05 24.9 10.7 12.5 1 1 14 15 15 15 14 Collagen triple helix repeat (20 copies) Carb_anhydrase PF00194.21 EMC82469.1 - 4.5e-62 209.9 0.1 1.7e-61 208.0 0.1 1.7 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase DUF4570 PF15134.6 EMC82470.1 - 2.1e-30 105.0 5.3 8.9e-28 96.5 5.3 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF4570) Cep3 PF16846.5 EMC82470.1 - 0.032 12.7 0.1 0.039 12.4 0.1 1.1 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit B zf-H2C2_2 PF13465.6 EMC82471.1 - 2.6e-30 103.5 38.1 1.7e-06 28.2 0.2 6.1 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.26 EMC82471.1 - 5.4e-20 70.7 53.6 1.2e-06 28.6 2.1 6.6 6 1 0 6 6 6 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC82471.1 - 2.2e-14 52.9 42.7 0.0008 20.0 0.8 6.2 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC82471.1 - 1.4e-05 25.0 35.3 0.00013 21.9 3.0 5.5 6 0 0 6 6 5 3 C2H2-type zinc finger zf-Sec23_Sec24 PF04810.15 EMC82471.1 - 0.0012 18.8 18.7 0.04 14.0 3.2 5.0 2 1 2 4 4 4 1 Sec23/Sec24 zinc finger Zn-ribbon_8 PF09723.10 EMC82471.1 - 0.0029 17.7 17.0 0.15 12.2 1.0 3.7 2 2 2 4 4 4 2 Zinc ribbon domain zf-C2HE PF16278.5 EMC82471.1 - 0.0062 17.0 29.4 1.3 9.5 2.3 4.7 2 2 2 4 4 4 2 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_3rep PF18868.1 EMC82471.1 - 0.01 16.5 17.1 1.6 9.5 0.4 4.3 1 1 3 4 4 4 1 Zinc finger C2H2-type, 3 repeats BolA PF01722.18 EMC82471.1 - 0.022 15.0 2.2 4.8 7.5 0.1 2.7 1 1 0 2 2 2 0 BolA-like protein zf-C2H2_jaz PF12171.8 EMC82471.1 - 0.023 15.0 40.0 0.23 11.8 0.5 6.4 6 2 1 7 7 7 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_9 PF14369.6 EMC82471.1 - 0.038 14.2 13.1 1.3 9.3 0.3 4.9 5 0 0 5 5 5 0 zinc-ribbon C1_2 PF03107.16 EMC82471.1 - 0.071 13.4 24.7 0.53 10.6 4.8 4.5 2 1 2 4 4 4 0 C1 domain DUF2489 PF10675.9 EMC82471.1 - 0.11 12.4 0.2 4.9 7.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) zf-AN1 PF01428.16 EMC82471.1 - 0.12 12.5 28.0 0.34 11.1 2.0 5.2 4 1 1 5 5 5 0 AN1-like Zinc finger DUF2180 PF09947.9 EMC82471.1 - 0.2 11.7 15.8 0.21 11.6 0.1 4.1 2 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2180) zf-C2H2_11 PF16622.5 EMC82471.1 - 0.23 11.3 0.3 0.23 11.3 0.3 4.7 5 0 0 5 5 5 0 zinc-finger C2H2-type Rep_fac-A_C PF08646.10 EMC82471.1 - 0.23 11.2 12.6 1.3 8.7 2.8 2.4 1 1 0 2 2 2 0 Replication factor-A C terminal domain zf-H2C2_5 PF13909.6 EMC82471.1 - 0.48 10.2 0.1 0.48 10.2 0.1 7.1 7 2 0 7 7 5 0 C2H2-type zinc-finger domain XPA_N PF01286.18 EMC82471.1 - 0.92 9.6 17.4 2.5 8.2 0.1 4.9 5 0 0 5 5 5 0 XPA protein N-terminal zf-C2H2_2 PF12756.7 EMC82471.1 - 1.3 9.4 25.0 1.1 9.7 3.1 4.4 1 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-trcl PF13451.6 EMC82471.1 - 1.5 8.8 18.6 13 5.8 0.2 5.1 5 0 0 5 5 5 0 Probable zinc-ribbon domain HypA PF01155.19 EMC82471.1 - 1.5 8.9 14.1 8.8 6.4 2.9 3.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.5 EMC82471.1 - 1.7 9.5 16.2 5.8 7.7 3.0 2.9 1 1 2 3 3 3 0 zinc-ribbon family zf-met PF12874.7 EMC82471.1 - 1.7 9.1 31.9 1.3 9.5 0.3 6.2 5 1 1 7 7 7 0 Zinc-finger of C2H2 type Zf_RING PF16744.5 EMC82471.1 - 2.5 8.3 17.1 0.64 10.2 3.9 3.6 1 1 2 4 4 4 0 KIAA1045 RING finger zf-C2H2_9 PF16293.5 EMC82471.1 - 3 7.8 10.9 7.9 6.4 0.6 3.7 3 2 1 4 4 4 0 C2H2 type zinc-finger (1 copy) PHD_4 PF16866.5 EMC82471.1 - 5.1 7.3 14.4 4.6 7.4 5.6 2.8 2 1 1 3 3 3 0 PHD-finger ADK_lid PF05191.14 EMC82471.1 - 5.9 7.0 17.4 1.5e+02 2.5 0.1 4.1 1 1 2 3 3 3 0 Adenylate kinase, active site lid GAGA PF09237.11 EMC82471.1 - 7 6.5 10.7 9.3 6.1 0.2 3.5 2 2 2 4 4 4 0 GAGA factor Ta0938 PF11494.8 EMC82471.1 - 8.2 6.8 11.3 2.7 8.3 4.5 2.8 2 2 1 3 3 3 0 Ta0938 FYDLN_acid PF09538.10 EMC82471.1 - 8.8 7.1 10.7 31 5.3 0.8 3.7 1 1 3 4 4 4 0 Protein of unknown function (FYDLN_acid) Glyco_transf_54 PF04666.13 EMC82472.1 - 2.2e-94 315.6 1.1 3.3e-94 315.0 1.1 1.2 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Glyco_transf_25 PF01755.17 EMC82472.1 - 0.0079 16.1 0.1 0.02 14.8 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase family 25 (LPS biosynthesis protein) DUF4373 PF14297.6 EMC82472.1 - 0.068 14.0 0.1 0.29 11.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4373) Pro-NT_NN PF07421.11 EMC82473.1 - 1.4e-73 246.5 2.5 1.6e-73 246.4 2.5 1.0 1 0 0 1 1 1 1 Neurotensin/neuromedin N precursor DUF1729 PF08354.10 EMC82473.1 - 0.11 11.3 0.2 0.17 10.8 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1729) Neurokinin_B PF03823.14 EMC82473.1 - 0.21 11.6 1.5 0.79 9.8 1.5 2.0 1 0 0 1 1 1 0 Neurokinin B Homeodomain PF00046.29 EMC82474.1 - 6.4e-24 83.6 6.3 1.6e-23 82.3 6.3 1.7 1 0 0 1 1 1 1 Homeodomain OAR PF03826.17 EMC82474.1 - 3.9e-09 36.0 3.2 9.2e-09 34.9 3.2 1.7 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.11 EMC82474.1 - 0.0013 18.6 0.2 0.0035 17.2 0.2 1.8 1 0 0 1 1 1 1 Homeobox KN domain IQ PF00612.27 EMC82475.1 - 5.5e-06 25.7 0.0 1.4e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif Baculo_p48 PF04878.13 EMC82475.1 - 0.078 11.9 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Baculovirus P48 protein LRR_4 PF12799.7 EMC82476.1 - 1.1e-22 79.7 46.1 1.2e-05 25.6 5.8 8.3 4 3 3 8 8 8 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMC82476.1 - 4.6e-16 58.3 41.5 0.00023 20.8 0.5 7.2 4 3 3 7 7 7 6 Leucine rich repeat LRR_9 PF14580.6 EMC82476.1 - 2.1e-09 37.1 11.9 2.7e-06 27.0 0.4 4.1 2 2 3 5 5 5 3 Leucine-rich repeat LRR_6 PF13516.6 EMC82476.1 - 0.0031 17.4 24.7 3.2 8.0 0.1 8.4 7 1 1 8 8 8 3 Leucine Rich repeat SNF PF00209.18 EMC82477.1 - 5.7e-225 747.9 31.0 6.9e-225 747.7 31.0 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Tmemb_18A PF09771.9 EMC82477.1 - 1.1 9.7 4.3 0.93 9.9 0.1 2.9 3 0 0 3 3 3 0 Transmembrane protein 188 RVT_1 PF00078.27 EMC82478.1 - 0.001 18.7 0.0 0.0016 18.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PSP1 PF04468.12 EMC82479.1 - 0.021 15.1 0.1 0.052 13.8 0.1 1.6 1 0 0 1 1 1 0 PSP1 C-terminal conserved region 7tm_1 PF00001.21 EMC82480.1 - 5.5e-36 124.2 33.9 1.4e-34 119.6 33.9 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC82480.1 - 5e-11 42.8 24.6 1.6e-10 41.2 16.6 2.6 1 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 EMC82480.1 - 2.3e-10 40.3 33.2 4.7e-10 39.3 33.2 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC82480.1 - 0.00064 19.4 23.4 0.00064 19.4 23.4 2.8 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Yae1_N PF09811.9 EMC82482.1 - 0.29 10.9 46.7 0.079 12.7 5.9 5.0 1 1 2 3 3 3 0 Essential protein Yae1, N terminal Cadherin PF00028.17 EMC82483.1 - 5.5e-85 280.0 7.0 3.3e-19 69.1 0.0 5.5 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 EMC82483.1 - 1.4e-57 194.1 0.9 3e-57 193.0 0.9 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_2 PF08266.12 EMC82483.1 - 2.2e-07 30.6 0.0 0.017 15.0 0.0 3.9 4 0 0 4 4 4 2 Cadherin-like Stevor PF17410.2 EMC82483.1 - 0.0033 17.0 0.1 0.0053 16.4 0.1 1.2 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame RET_CLD1 PF17756.1 EMC82483.1 - 0.0098 16.2 0.0 0.88 9.9 0.0 3.0 3 0 0 3 3 3 1 RET Cadherin like domain 1 Cadherin_4 PF17803.1 EMC82483.1 - 0.038 14.6 1.5 0.038 14.6 1.5 4.6 6 0 0 6 6 5 0 Bacterial cadherin-like domain Sigma_1s PF02454.16 EMC82483.1 - 0.055 13.5 0.1 3.2 7.8 0.0 2.4 2 0 0 2 2 2 0 Sigma 1s protein ASFV_J13L PF05568.11 EMC82483.1 - 0.057 13.2 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 African swine fever virus J13L protein Y_Y_Y PF07495.13 EMC82483.1 - 0.11 12.5 0.0 28 4.8 0.0 3.8 4 0 0 4 4 4 0 Y_Y_Y domain VirB3 PF05101.13 EMC82483.1 - 0.26 11.6 0.4 0.48 10.7 0.4 1.4 1 0 0 1 1 1 0 Type IV secretory pathway, VirB3-like protein RIFIN PF02009.16 EMC82483.1 - 0.33 10.8 0.8 0.59 10.0 0.8 1.3 1 0 0 1 1 1 0 Rifin Yae1_N PF09811.9 EMC82485.1 - 3.9e-12 45.6 42.5 1.8e+04 -8.1 42.5 4.5 1 1 0 1 1 1 0 Essential protein Yae1, N terminal Arfaptin PF06456.13 EMC82487.1 - 2.9e-46 157.9 1.9 3.3e-46 157.7 1.9 1.0 1 0 0 1 1 1 1 Arfaptin-like domain Sad1_UNC PF07738.13 EMC82488.1 - 4.4e-20 72.1 0.0 6.2e-20 71.6 0.0 1.2 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Neisseria_TspB PF05616.13 EMC82488.1 - 0.21 10.0 0.0 0.27 9.7 0.0 1.1 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein 7tm_1 PF00001.21 EMC82489.1 - 3.1e-23 82.4 5.4 4.1e-23 82.0 5.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC82489.1 - 9.3e-19 68.2 4.5 1.1e-18 67.9 4.5 1.1 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC82489.1 - 3.6e-08 33.4 5.6 4.8e-08 32.9 5.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 EMC82489.1 - 0.00017 21.1 6.6 0.00023 20.6 6.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv DUF2189 PF09955.9 EMC82489.1 - 0.039 14.2 7.8 1.5 9.1 2.2 2.2 1 1 0 2 2 2 0 Predicted integral membrane protein (DUF2189) RhoGAP PF00620.27 EMC82491.1 - 6.4e-27 94.2 0.1 1.5e-26 93.0 0.1 1.6 1 0 0 1 1 1 1 RhoGAP domain Guanylate_cyc PF00211.20 EMC82492.1 - 1.6e-63 213.6 0.0 2.5e-63 213.0 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 EMC82492.1 - 3.8e-46 157.3 2.6 3e-44 151.1 2.6 2.3 1 1 0 1 1 1 1 Heme NO binding associated HNOB PF07700.15 EMC82492.1 - 3.3e-07 30.4 0.1 5.9e-07 29.6 0.1 1.4 1 0 0 1 1 1 1 Haem-NO-binding Guanylate_cyc PF00211.20 EMC82493.1 - 8e-66 221.1 0.0 1.2e-65 220.6 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 EMC82493.1 - 8.6e-57 192.1 0.0 2e-56 190.9 0.0 1.6 1 1 0 1 1 1 1 Heme NO binding associated HNOB PF07700.15 EMC82493.1 - 5.7e-46 156.5 0.0 9.4e-46 155.8 0.0 1.3 1 0 0 1 1 1 1 Haem-NO-binding ASC PF00858.24 EMC82494.1 - 8.7e-88 295.2 10.2 1.1e-87 294.8 10.2 1.2 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel zinc_ribbon_13 PF09855.9 EMC82494.1 - 0.082 13.1 0.5 0.27 11.4 0.0 2.1 2 0 0 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) Trp_dioxygenase PF03301.13 EMC82495.1 - 8.5e-165 548.2 5.1 9.9e-165 548.0 5.1 1.0 1 0 0 1 1 1 1 Tryptophan 2,3-dioxygenase Peptidase_C1 PF00112.23 EMC82496.1 - 2.1e-58 198.0 3.6 2.5e-58 197.8 3.6 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EMC82496.1 - 2.7e-07 29.7 0.1 0.0012 17.7 0.0 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Inhibitor_I29 PF08246.12 EMC82496.1 - 0.16 12.5 0.5 0.36 11.3 0.2 1.8 2 0 0 2 2 2 0 Cathepsin propeptide inhibitor domain (I29) DnaJ_C PF01556.18 EMC82499.1 - 3e-42 144.2 0.0 3.8e-42 143.9 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 EMC82499.1 - 2e-14 53.7 17.0 3.5e-14 52.9 17.0 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EMC82499.1 - 0.00051 19.9 11.0 0.011 15.7 2.2 3.1 3 0 0 3 3 3 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EMC82499.1 - 0.0012 18.8 6.4 0.033 14.2 0.1 2.4 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 EMC82499.1 - 0.11 12.5 0.6 0.11 12.5 0.6 2.5 2 0 0 2 2 2 0 Double zinc ribbon zinc-ribbons_6 PF07191.12 EMC82499.1 - 3.3 7.8 10.9 0.91 9.5 4.1 2.4 1 1 1 2 2 2 0 zinc-ribbons Filament PF00038.21 EMC82500.1 - 2.6e-36 125.8 36.9 3.1e-36 125.5 36.9 1.1 1 0 0 1 1 1 1 Intermediate filament protein GAS PF13851.6 EMC82500.1 - 0.011 15.0 16.4 0.011 15.0 16.4 3.1 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 EMC82500.1 - 0.024 15.2 19.5 0.024 15.2 19.5 4.1 1 1 2 3 3 3 0 Apg6 coiled-coil region bZIP_2 PF07716.15 EMC82500.1 - 0.15 12.2 0.3 0.15 12.2 0.3 5.5 5 0 0 5 5 5 0 Basic region leucine zipper DUF4472 PF14739.6 EMC82500.1 - 0.87 10.4 36.6 2.8 8.7 7.0 4.2 2 2 2 4 4 4 0 Domain of unknown function (DUF4472) HALZ PF02183.18 EMC82500.1 - 1 9.6 20.0 0.38 11.0 1.1 5.3 5 1 0 5 5 5 0 Homeobox associated leucine zipper DUF3037 PF11236.8 EMC82500.1 - 2.1 8.8 12.9 0.4 11.1 2.3 3.5 2 2 1 3 3 3 0 Protein of unknown function (DUF3037) FAM76 PF16046.5 EMC82500.1 - 2.2 7.6 18.9 0.48 9.7 6.2 2.1 2 0 0 2 2 2 0 FAM76 protein MalF_P2 PF14785.6 EMC82500.1 - 8 6.5 10.1 0.52 10.3 4.1 1.9 2 0 0 2 2 2 0 Maltose transport system permease protein MalF P2 domain Exonuc_VII_L PF02601.15 EMC82500.1 - 9.4 5.7 28.2 2.8 7.4 11.3 2.1 1 1 1 2 2 2 0 Exonuclease VII, large subunit PT PF04886.12 EMC82501.1 - 0.3 10.6 13.3 9.8 5.8 6.0 3.8 3 2 0 3 3 3 0 PT repeat Xlink PF00193.17 EMC82502.1 - 8e-42 141.5 7.0 3.6e-31 107.4 0.2 4.7 4 1 1 5 5 5 3 Extracellular link domain V-set PF07686.17 EMC82502.1 - 2.8e-08 33.9 0.0 1.1e-07 32.0 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin V-set domain Lectin_C PF00059.21 EMC82502.1 - 4.6e-07 30.5 0.2 0.00017 22.3 0.0 2.9 3 0 0 3 3 3 1 Lectin C-type domain EGF PF00008.27 EMC82502.1 - 5.2e-07 29.9 10.2 5.2e-07 29.9 10.2 3.5 3 0 0 3 3 3 1 EGF-like domain hEGF PF12661.7 EMC82502.1 - 4.9e-05 23.8 5.7 4.9e-05 23.8 5.7 4.7 6 0 0 6 6 6 1 Human growth factor-like EGF ig PF00047.25 EMC82502.1 - 0.021 15.0 0.0 0.043 14.0 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain Cauli_VI PF01693.16 EMC82502.1 - 0.04 14.2 0.6 0.32 11.4 0.3 2.4 1 1 1 2 2 2 0 Caulimovirus viroplasmin Chordopox_A33R PF05966.12 EMC82502.1 - 0.088 12.1 0.3 7.5 5.8 0.1 2.3 2 0 0 2 2 2 0 Chordopoxvirus A33R protein Izumo-Ig PF16706.5 EMC82502.1 - 0.15 12.1 0.0 0.38 10.8 0.0 1.6 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain I-set PF07679.16 EMC82502.1 - 0.17 12.0 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain Xlink PF00193.17 EMC82503.1 - 8.9e-55 183.1 0.1 5.2e-26 90.9 0.0 2.2 2 0 0 2 2 2 2 Extracellular link domain V-set PF07686.17 EMC82503.1 - 1.9e-15 56.9 0.0 3.5e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC82503.1 - 7.6e-09 36.0 0.0 1.6e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC82503.1 - 2.7e-08 33.8 0.0 4.8e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC82503.1 - 2.5e-06 27.6 0.0 1.5e-05 25.0 0.0 2.0 1 1 0 1 1 1 1 Immunoglobulin domain Izumo-Ig PF16706.5 EMC82503.1 - 0.00061 19.8 0.0 0.0013 18.8 0.0 1.5 1 0 0 1 1 1 1 Izumo-like Immunoglobulin domain Ig_2 PF13895.6 EMC82503.1 - 0.0032 17.8 0.1 0.022 15.1 0.1 2.1 1 1 0 1 1 1 1 Immunoglobulin domain Ammonium_transp PF00909.21 EMC82504.1 - 7e-27 94.1 12.6 1.4e-26 93.2 12.6 1.5 1 1 0 1 1 1 1 Ammonium Transporter Family DUF1003 PF06210.11 EMC82504.1 - 0.85 9.8 8.1 0.26 11.4 3.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1003) Nop14 PF04147.12 EMC82505.1 - 0.00082 17.7 35.2 0.0011 17.3 35.2 1.0 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.12 EMC82505.1 - 0.038 13.4 36.2 0.055 12.9 36.2 1.1 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 EMC82505.1 - 0.079 12.3 29.2 0.13 11.6 29.2 1.2 1 0 0 1 1 1 0 BUD22 CDC27 PF09507.10 EMC82505.1 - 0.36 10.2 24.3 0.66 9.3 24.3 1.4 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Caldesmon PF02029.15 EMC82505.1 - 0.44 9.3 34.9 0.61 8.8 34.9 1.1 1 0 0 1 1 1 0 Caldesmon RNA_pol_Rpc4 PF05132.14 EMC82505.1 - 0.68 10.4 14.5 2.4 8.6 14.5 2.0 1 0 0 1 1 1 0 RNA polymerase III RPC4 TFIIF_alpha PF05793.12 EMC82505.1 - 0.77 8.3 39.4 1.2 7.7 39.4 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Mpp10 PF04006.12 EMC82505.1 - 0.98 7.8 42.3 1.4 7.3 42.3 1.0 1 0 0 1 1 1 0 Mpp10 protein RNA_polI_A34 PF08208.11 EMC82505.1 - 1.1 9.3 36.4 0.076 13.1 30.6 1.9 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 Tim54 PF11711.8 EMC82505.1 - 1.4 7.6 24.6 2.2 7.0 24.6 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CDC45 PF02724.14 EMC82505.1 - 2 6.6 31.5 2.7 6.2 31.5 1.1 1 0 0 1 1 1 0 CDC45-like protein VIR_N PF15912.5 EMC82505.1 - 2 7.9 23.2 4.1 6.9 23.2 1.4 1 0 0 1 1 1 0 Virilizer, N-terminal DDHD PF02862.17 EMC82505.1 - 2 8.5 6.1 3.3 7.8 6.1 1.2 1 0 0 1 1 1 0 DDHD domain SpoIIP PF07454.11 EMC82505.1 - 2.8 7.3 19.7 4.1 6.8 19.7 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) RR_TM4-6 PF06459.12 EMC82505.1 - 3.5 7.4 30.8 5.3 6.8 30.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SpoIIIAH PF12685.7 EMC82505.1 - 3.7 7.3 18.2 5.5 6.8 18.2 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein RcnB PF11776.8 EMC82507.1 - 0.72 10.0 10.2 24 5.1 0.1 4.2 4 1 1 5 5 5 0 Nickel/cobalt transporter regulator 7tm_4 PF13853.6 EMC82509.1 - 8.4e-27 94.6 6.0 1e-26 94.3 6.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC82509.1 - 1.7e-25 89.8 6.1 2.3e-25 89.4 6.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC82509.1 - 0.00062 19.5 6.1 0.00088 19.0 6.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 EMC82509.1 - 0.0021 17.5 5.7 0.0024 17.3 5.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Laminin_G_2 PF02210.24 EMC82510.1 - 6.9e-22 78.4 0.2 4.9e-16 59.4 0.1 2.1 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 EMC82510.1 - 1e-15 58.1 0.0 3.6e-11 43.4 0.0 2.1 2 0 0 2 2 2 2 Laminin G domain DUF4154 PF13689.6 EMC82510.1 - 0.077 13.2 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 YfiR/HmsC-like Lipase_GDSL_2 PF13472.6 EMC82511.1 - 0.094 13.1 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Laminin_G_2 PF02210.24 EMC82512.1 - 1.6e-45 154.7 0.0 1.9e-23 83.4 0.1 2.3 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 EMC82512.1 - 1.3e-28 99.9 0.0 2.7e-14 53.5 0.0 2.5 2 1 0 2 2 2 2 Laminin G domain Syndecan PF01034.20 EMC82512.1 - 0.014 15.3 0.0 0.028 14.3 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain hEGF PF12661.7 EMC82512.1 - 0.019 15.6 6.4 0.019 15.6 6.4 3.0 3 0 0 3 3 3 0 Human growth factor-like EGF MARVEL PF01284.23 EMC82512.1 - 0.087 12.8 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Membrane-associating domain PRC2_HTH_1 PF18118.1 EMC82513.1 - 2.1e-31 108.7 3.6 2.1e-31 108.7 3.6 2.7 2 0 0 2 2 2 1 Polycomb repressive complex 2 tri-helical domain SET PF00856.28 EMC82513.1 - 3.6e-18 66.5 6.2 6.5e-18 65.7 0.5 3.0 2 2 0 2 2 2 1 SET domain EZH2_WD-Binding PF11616.8 EMC82513.1 - 3e-16 59.2 3.5 7.3e-16 58.0 3.5 1.7 1 0 0 1 1 1 1 WD repeat binding protein EZH2 preSET_CXC PF18264.1 EMC82513.1 - 4.8e-12 46.1 15.6 4.8e-12 46.1 15.6 3.9 2 1 0 2 2 2 1 CXC domain CDC45 PF02724.14 EMC82513.1 - 8 4.6 7.9 11 4.2 2.2 2.1 2 0 0 2 2 2 0 CDC45-like protein Thioredoxin PF00085.20 EMC82514.1 - 5.2e-54 180.6 0.1 7.2e-32 109.4 0.0 2.0 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_8 PF13905.6 EMC82514.1 - 7.3e-11 42.3 0.0 0.00049 20.4 0.0 3.2 2 1 1 3 3 3 3 Thioredoxin-like Thioredoxin_2 PF13098.6 EMC82514.1 - 2.3e-08 34.5 0.1 0.00076 19.9 0.1 2.4 2 1 0 2 2 2 2 Thioredoxin-like domain AhpC-TSA PF00578.21 EMC82514.1 - 8.4e-08 32.2 0.0 0.014 15.3 0.0 2.2 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_7 PF13899.6 EMC82514.1 - 3e-07 30.5 0.0 0.008 16.3 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like OST3_OST6 PF04756.13 EMC82514.1 - 1.2e-06 28.1 0.0 3.2e-05 23.4 0.0 2.1 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Redoxin PF08534.10 EMC82514.1 - 3.3e-05 23.6 0.1 0.12 12.1 0.0 2.3 2 0 0 2 2 2 2 Redoxin Thioredoxin_4 PF13462.6 EMC82514.1 - 0.001 19.3 1.0 1.1 9.4 0.1 2.6 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_9 PF14595.6 EMC82514.1 - 0.0041 16.9 0.0 0.63 9.8 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin DSBA PF01323.20 EMC82514.1 - 0.013 15.3 0.3 8.3 6.1 0.1 3.0 2 1 1 3 3 3 0 DSBA-like thioredoxin domain TraF PF13728.6 EMC82514.1 - 0.016 15.1 0.0 0.48 10.2 0.0 2.2 2 0 0 2 2 2 0 F plasmid transfer operon protein RAMP PF04901.13 EMC82515.1 - 2.8e-44 149.6 4.0 3.2e-44 149.4 4.0 1.0 1 0 0 1 1 1 1 Receptor activity modifying family Thyroglobulin_1 PF00086.18 EMC82517.1 - 2.9e-19 68.5 2.6 5.6e-19 67.6 2.6 1.5 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat DUF4829 PF16111.5 EMC82517.1 - 0.0087 16.8 0.1 0.012 16.4 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4829) C1_1 PF00130.22 EMC82519.1 - 0.0014 18.5 1.0 0.0022 17.8 1.0 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kazal_2 PF07648.15 EMC82520.1 - 2.6e-11 43.5 38.7 5.5e-05 23.2 4.2 5.7 4 1 1 5 5 5 3 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EMC82520.1 - 4.4e-10 39.4 30.1 0.00059 19.8 3.7 5.2 3 1 1 4 4 4 3 Kazal-type serine protease inhibitor domain Ldl_recept_a PF00057.18 EMC82520.1 - 0.0054 16.9 3.1 0.0054 16.9 3.1 7.1 6 0 0 6 6 6 1 Low-density lipoprotein receptor domain class A VWC PF00093.18 EMC82520.1 - 0.011 16.1 4.6 0.011 16.1 4.6 9.6 7 3 3 10 10 10 0 von Willebrand factor type C domain DNA_pol_E_B PF04042.16 EMC82520.1 - 0.019 14.3 0.0 0.036 13.4 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B Pkinase PF00069.25 EMC82521.1 - 3.9e-36 124.8 0.0 6.3e-36 124.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC82521.1 - 8.2e-35 120.3 0.0 1.1e-34 119.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TGF_beta_GS PF08515.12 EMC82521.1 - 2.9e-17 61.8 0.4 5.4e-17 61.0 0.4 1.5 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Activin_recp PF01064.23 EMC82521.1 - 1e-08 36.1 8.3 1e-08 36.1 8.3 1.8 2 0 0 2 2 2 1 Activin types I and II receptor domain Pkinase_fungal PF17667.1 EMC82521.1 - 3.3e-05 22.8 0.7 0.00025 20.0 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EMC82521.1 - 0.012 15.6 0.0 0.025 14.5 0.0 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EMC82521.1 - 0.04 12.9 0.0 0.2 10.6 0.0 1.9 2 0 0 2 2 2 0 Haspin like kinase domain FTA2 PF13095.6 EMC82521.1 - 0.11 12.1 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 AAA PF00004.29 EMC82522.1 - 5.6e-31 107.7 0.0 8.8e-31 107.1 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EMC82522.1 - 1.7e-07 31.6 0.1 2.5e-06 27.8 0.3 2.6 2 1 0 2 2 1 1 AAA domain AAA_18 PF13238.6 EMC82522.1 - 4.1e-06 27.4 0.0 1.6e-05 25.4 0.0 2.1 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.6 EMC82522.1 - 6.1e-06 26.7 0.0 1.6e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 EMC82522.1 - 3.5e-05 23.8 0.0 9.6e-05 22.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EMC82522.1 - 0.00011 21.9 0.0 0.062 12.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EMC82522.1 - 0.00013 22.2 0.0 0.00025 21.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 EMC82522.1 - 0.00025 20.9 0.0 0.00094 19.0 0.0 2.0 3 0 0 3 3 1 1 Cytidylate kinase IstB_IS21 PF01695.17 EMC82522.1 - 0.00037 20.3 0.0 0.0016 18.2 0.0 1.9 1 1 0 2 2 2 1 IstB-like ATP binding protein ATPase_2 PF01637.18 EMC82522.1 - 0.00071 19.6 0.4 1.1 9.1 0.3 2.4 1 1 1 2 2 2 2 ATPase domain predominantly from Archaea NACHT PF05729.12 EMC82522.1 - 0.001 19.0 0.2 0.0042 17.0 0.2 2.1 1 1 0 1 1 1 1 NACHT domain AAA_24 PF13479.6 EMC82522.1 - 0.0014 18.4 0.0 0.0029 17.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EMC82522.1 - 0.0014 18.4 0.0 0.0052 16.6 0.0 1.9 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EMC82522.1 - 0.0014 19.0 0.0 0.0041 17.5 0.0 1.8 1 0 0 1 1 1 1 RNA helicase AAA_5 PF07728.14 EMC82522.1 - 0.0018 18.3 0.1 0.0039 17.2 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EMC82522.1 - 0.0023 17.7 0.0 0.0054 16.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 EMC82522.1 - 0.0026 17.8 0.0 0.005 16.8 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Viral_helicase1 PF01443.18 EMC82522.1 - 0.0027 17.5 0.0 0.006 16.3 0.0 1.6 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 EMC82522.1 - 0.0029 17.5 0.0 0.0056 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 EMC82522.1 - 0.003 16.8 0.1 0.012 14.8 0.1 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF815) AAA_28 PF13521.6 EMC82522.1 - 0.003 17.8 0.0 0.0064 16.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain KAP_NTPase PF07693.14 EMC82522.1 - 0.003 16.8 0.3 0.88 8.7 0.2 2.3 1 1 0 2 2 2 1 KAP family P-loop domain AAA_7 PF12775.7 EMC82522.1 - 0.0057 16.2 0.0 0.017 14.7 0.0 1.7 2 0 0 2 2 1 1 P-loop containing dynein motor region ABC_tran PF00005.27 EMC82522.1 - 0.0065 17.0 0.0 0.017 15.7 0.0 1.8 2 0 0 2 2 1 1 ABC transporter PduV-EutP PF10662.9 EMC82522.1 - 0.0081 15.9 0.0 0.021 14.6 0.0 1.8 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation ATPase PF06745.13 EMC82522.1 - 0.01 15.2 0.2 0.58 9.5 0.0 2.4 1 1 1 2 2 2 0 KaiC AAA_17 PF13207.6 EMC82522.1 - 0.012 16.0 0.0 0.034 14.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain TIP49 PF06068.13 EMC82522.1 - 0.013 14.7 0.0 0.02 14.1 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain FtsK_SpoIIIE PF01580.18 EMC82522.1 - 0.014 14.7 0.1 3.7 6.8 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family Rad17 PF03215.15 EMC82522.1 - 0.02 14.8 1.0 0.051 13.5 0.4 2.1 2 1 0 2 2 1 0 Rad17 P-loop domain Mg_chelatase PF01078.21 EMC82522.1 - 0.022 14.1 0.0 0.1 11.9 0.0 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 EMC82522.1 - 0.033 14.5 0.0 0.15 12.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 EMC82522.1 - 0.035 13.5 0.0 0.13 11.6 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_2 PF07724.14 EMC82522.1 - 0.044 13.9 0.0 0.094 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) DUF2075 PF09848.9 EMC82522.1 - 0.074 12.3 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_6 PF12774.7 EMC82522.1 - 0.076 12.0 0.1 0.33 9.9 0.0 2.0 1 1 1 2 2 2 0 Hydrolytic ATP binding site of dynein motor region Zot PF05707.12 EMC82522.1 - 0.08 12.6 0.3 1.4 8.6 0.3 2.3 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_3 PF07726.11 EMC82522.1 - 0.093 12.6 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) D5_N PF08706.11 EMC82522.1 - 0.12 12.6 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 D5 N terminal like Peptidase_M78 PF06114.13 EMC82522.1 - 0.16 11.9 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 IrrE N-terminal-like domain CPT PF07931.12 EMC82522.1 - 0.17 11.7 0.0 0.35 10.7 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein NTPase_1 PF03266.15 EMC82522.1 - 0.19 11.6 0.9 0.71 9.8 0.0 2.3 3 0 0 3 3 2 0 NTPase DUF3512 PF12024.8 EMC82523.1 - 3.3e-82 275.5 0.6 3.3e-82 275.5 0.6 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3512) Bromodomain PF00439.25 EMC82523.1 - 6.4e-25 87.0 0.1 1.3e-23 82.8 0.1 2.5 2 0 0 2 2 2 1 Bromodomain Zip PF02535.22 EMC82523.1 - 0.4 9.9 1.2 0.67 9.1 1.2 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter CPSF100_C PF13299.6 EMC82523.1 - 0.84 9.8 8.0 0.4 10.8 3.6 2.6 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal NPR3 PF03666.13 EMC82523.1 - 1.1 8.0 8.7 0.12 11.1 3.5 1.9 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 NARP1 PF12569.8 EMC82523.1 - 1.4 7.7 15.3 2.9 6.7 15.3 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CDC45 PF02724.14 EMC82523.1 - 1.9 6.7 12.7 3 6.0 12.7 1.3 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 EMC82523.1 - 7 5.3 7.2 12 4.6 7.2 1.3 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 EMC82523.1 - 8.4 6.1 8.2 16 5.2 8.2 1.4 1 0 0 1 1 1 0 Connexin U79_P34 PF03064.16 EMC82523.1 - 9 5.6 21.6 18 4.6 21.6 1.4 1 0 0 1 1 1 0 HSV U79 / HCMV P34 p25-alpha PF05517.12 EMC82524.1 - 1.6e-67 226.5 5.3 2e-67 226.2 5.3 1.1 1 0 0 1 1 1 1 p25-alpha HGD-D PF06050.13 EMC82524.1 - 0.016 15.0 0.0 0.017 14.9 0.0 1.0 1 0 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component Rep_3 PF01051.21 EMC82524.1 - 0.029 14.2 0.3 0.041 13.7 0.3 1.2 1 0 0 1 1 1 0 Initiator Replication protein Drf_FH3 PF06367.16 EMC82524.1 - 0.099 12.2 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Diaphanous FH3 Domain Na_H_Exchanger PF00999.21 EMC82525.1 - 8e-75 252.0 47.2 1.2e-72 244.9 47.2 2.1 1 1 0 1 1 1 1 Sodium/hydrogen exchanger family DALR_1 PF05746.15 EMC82525.1 - 0.12 12.5 0.3 0.27 11.4 0.3 1.5 1 0 0 1 1 1 0 DALR anticodon binding domain NEXCaM_BD PF16644.5 EMC82525.1 - 0.2 11.9 3.7 0.4 10.9 3.7 1.4 1 0 0 1 1 1 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin CxC2 PF18803.1 EMC82526.1 - 1.5e-05 25.1 0.0 4.6e-05 23.5 0.0 1.8 1 0 0 1 1 1 1 CxC2 like cysteine cluster associated with KDZ transposases LRR_1 PF00560.33 EMC82526.1 - 0.0019 18.5 6.4 7.9 7.5 0.0 5.2 4 0 0 4 4 4 2 Leucine Rich Repeat LRR_6 PF13516.6 EMC82526.1 - 0.0036 17.3 4.7 4.7 7.5 0.0 4.5 4 0 0 4 4 4 2 Leucine Rich repeat PPIP5K2_N PF18086.1 EMC82526.1 - 0.071 13.3 0.1 10 6.4 0.1 2.9 2 0 0 2 2 2 0 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain LRR_8 PF13855.6 EMC82526.1 - 0.23 11.2 6.4 0.26 11.1 3.2 3.0 2 1 1 3 3 3 0 Leucine rich repeat AA_permease PF00324.21 EMC82528.1 - 3.9e-63 213.7 28.9 2.4e-39 135.3 5.1 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.15 EMC82528.1 - 1.4e-37 129.8 9.3 5.4e-15 55.3 0.1 3.4 1 1 1 3 3 3 3 Solute carrier family 12 R3H PF01424.22 EMC82529.1 - 1.8e-18 66.3 0.1 3.1e-18 65.5 0.1 1.4 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 EMC82529.1 - 2.6e-16 59.3 187.5 1.5e-05 25.0 11.7 13.4 12 1 0 12 12 12 7 NF-X1 type zinc finger DUF5087 PF17006.5 EMC82531.1 - 0.00099 18.7 0.5 0.0018 17.9 0.5 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF5087) Lectin_C PF00059.21 EMC82532.1 - 3.1e-13 50.4 6.0 3.1e-13 50.4 6.0 1.9 2 0 0 2 2 2 1 Lectin C-type domain Ly49 PF08391.10 EMC82532.1 - 0.0039 17.5 0.2 0.0092 16.3 0.1 1.7 2 1 0 2 2 2 1 Ly49-like protein, N-terminal region YajC PF02699.15 EMC82532.1 - 0.22 11.4 0.2 4.6 7.2 0.0 2.2 2 0 0 2 2 2 0 Preprotein translocase subunit Histone PF00125.24 EMC82533.1 - 2.6e-08 34.3 0.5 2.6e-08 34.3 0.5 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC82533.1 - 3.6e-05 23.9 0.1 3.6e-05 23.9 0.1 1.5 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TED_complement PF07678.14 EMC82534.1 - 2.2e-104 348.9 0.1 3.2e-104 348.3 0.1 1.2 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M_BRD PF07703.14 EMC82534.1 - 1.8e-30 106.1 2.1 4.2e-28 98.4 0.0 3.0 3 0 0 3 3 3 2 Alpha-2-macroglobulin bait region domain A2M PF00207.22 EMC82534.1 - 1.8e-28 98.2 0.1 4.3e-28 97.0 0.1 1.7 1 0 0 1 1 1 1 Alpha-2-macroglobulin family A2M_recep PF07677.14 EMC82534.1 - 1.1e-25 90.2 1.0 3.6e-25 88.5 1.0 2.1 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain MG3 PF17791.1 EMC82534.1 - 4.6e-25 87.7 0.3 5.5e-24 84.2 0.3 2.9 2 0 0 2 2 2 1 Macroglobulin domain MG3 MG2 PF01835.19 EMC82534.1 - 3e-20 72.4 0.0 1.9e-19 69.9 0.0 2.5 3 0 0 3 3 2 1 MG2 domain MG4 PF17789.1 EMC82534.1 - 1.6e-18 66.6 0.1 8.6e-18 64.3 0.0 2.3 2 0 0 2 2 2 1 Macroglobulin domain MG4 SQHop_cyclase_C PF13243.6 EMC82534.1 - 2.3e-05 23.6 0.1 0.026 13.6 0.1 2.2 1 1 0 2 2 2 2 Squalene-hopene cyclase C-terminal domain MG1 PF17790.1 EMC82534.1 - 0.00071 20.0 0.3 0.016 15.6 0.0 3.1 3 0 0 3 3 3 1 Macroglobulin domain MG1 SVA PF05326.11 EMC82534.1 - 0.0059 16.6 0.0 0.016 15.2 0.0 1.7 1 0 0 1 1 1 1 Seminal vesicle autoantigen (SVA) Big_1 PF02369.16 EMC82534.1 - 0.037 14.0 0.0 0.23 11.5 0.0 2.4 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) Prenyltrans PF00432.21 EMC82534.1 - 0.11 12.2 0.2 0.46 10.3 0.0 2.2 2 0 0 2 2 2 0 Prenyltransferase and squalene oxidase repeat TED_complement PF07678.14 EMC82535.1 - 5.8e-115 383.6 2.1 7.9e-115 383.2 2.1 1.2 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M_BRD PF07703.14 EMC82535.1 - 3.8e-32 111.5 1.8 1.2e-29 103.5 0.1 3.1 2 0 0 2 2 2 2 Alpha-2-macroglobulin bait region domain A2M PF00207.22 EMC82535.1 - 5.1e-28 96.8 0.0 1.8e-27 95.0 0.0 2.0 1 0 0 1 1 1 1 Alpha-2-macroglobulin family MG3 PF17791.1 EMC82535.1 - 2.6e-24 85.3 2.2 3.4e-24 84.9 0.5 2.2 2 0 0 2 2 2 1 Macroglobulin domain MG3 A2M_recep PF07677.14 EMC82535.1 - 8.2e-24 84.1 0.3 2.6e-23 82.5 0.3 2.0 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain MG4 PF17789.1 EMC82535.1 - 1.5e-20 73.1 0.4 6.7e-20 71.0 0.0 2.4 2 0 0 2 2 2 1 Macroglobulin domain MG4 MG2 PF01835.19 EMC82535.1 - 2.5e-19 69.5 0.0 8e-19 67.9 0.0 1.9 1 0 0 1 1 1 1 MG2 domain MG1 PF17790.1 EMC82535.1 - 0.0024 18.3 0.0 0.015 15.7 0.0 2.5 1 0 0 1 1 1 1 Macroglobulin domain MG1 SVA PF05326.11 EMC82535.1 - 0.0087 16.1 0.0 0.043 13.8 0.0 2.2 1 0 0 1 1 1 1 Seminal vesicle autoantigen (SVA) Prenyltrans PF00432.21 EMC82535.1 - 0.019 14.7 0.1 0.38 10.5 0.0 2.8 2 0 0 2 2 2 0 Prenyltransferase and squalene oxidase repeat TED_complement PF07678.14 EMC82536.1 - 1.5e-89 300.1 0.1 2.1e-89 299.6 0.1 1.2 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M PF00207.22 EMC82536.1 - 2.8e-31 107.2 0.3 8.8e-31 105.6 0.2 2.0 2 0 0 2 2 2 1 Alpha-2-macroglobulin family A2M_BRD PF07703.14 EMC82536.1 - 1e-30 106.9 0.1 3e-27 95.7 0.0 3.0 2 0 0 2 2 2 2 Alpha-2-macroglobulin bait region domain MG3 PF17791.1 EMC82536.1 - 7.6e-25 87.0 0.5 6.8e-24 83.9 0.4 2.8 2 0 0 2 2 2 1 Macroglobulin domain MG3 MG2 PF01835.19 EMC82536.1 - 8.9e-17 61.3 0.0 3.4e-16 59.5 0.0 2.1 1 0 0 1 1 1 1 MG2 domain MG4 PF17789.1 EMC82536.1 - 1e-15 57.6 0.0 3.8e-15 55.8 0.0 2.1 1 0 0 1 1 1 1 Macroglobulin domain MG4 SVA PF05326.11 EMC82536.1 - 0.00079 19.4 0.1 0.002 18.1 0.1 1.7 1 0 0 1 1 1 1 Seminal vesicle autoantigen (SVA) CarboxypepD_reg PF13620.6 EMC82536.1 - 0.0047 17.2 0.0 0.021 15.1 0.0 2.2 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain Big_1 PF02369.16 EMC82536.1 - 0.0085 16.1 2.0 0.015 15.3 0.6 2.2 2 0 0 2 2 2 1 Bacterial Ig-like domain (group 1) TED_complement PF07678.14 EMC82537.1 - 5.8e-90 301.5 0.1 8.4e-90 301.0 0.1 1.2 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M_BRD PF07703.14 EMC82537.1 - 1.1e-31 110.0 0.2 6.9e-29 101.0 0.0 3.0 2 0 0 2 2 2 1 Alpha-2-macroglobulin bait region domain A2M PF00207.22 EMC82537.1 - 6.1e-30 102.9 0.8 1.4e-29 101.8 0.1 2.0 2 0 0 2 2 2 1 Alpha-2-macroglobulin family MG3 PF17791.1 EMC82537.1 - 4e-26 91.1 0.5 4.8e-25 87.7 0.4 2.7 2 0 0 2 2 2 1 Macroglobulin domain MG3 MG4 PF17789.1 EMC82537.1 - 4.7e-23 81.1 0.0 6.6e-22 77.5 0.0 2.9 2 0 0 2 2 2 1 Macroglobulin domain MG4 MG2 PF01835.19 EMC82537.1 - 8.2e-19 67.9 0.0 2.3e-18 66.4 0.0 1.8 1 0 0 1 1 1 1 MG2 domain CarboxypepD_reg PF13620.6 EMC82537.1 - 0.0061 16.8 1.1 0.1 12.9 0.1 3.0 3 0 0 3 3 3 1 Carboxypeptidase regulatory-like domain MG1 PF17790.1 EMC82537.1 - 0.0077 16.6 0.9 0.035 14.5 0.2 2.6 2 0 0 2 2 2 1 Macroglobulin domain MG1 SVA PF05326.11 EMC82537.1 - 0.012 15.6 0.1 0.084 12.9 0.0 2.4 3 0 0 3 3 3 0 Seminal vesicle autoantigen (SVA) Big_1 PF02369.16 EMC82537.1 - 0.018 15.0 0.1 0.14 12.2 0.0 2.6 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 1) DUF4773 PF15998.5 EMC82537.1 - 0.41 11.2 1.5 1.1 9.8 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4773) Man-6-P_recep PF02157.15 EMC82538.1 - 3.9e-129 429.1 0.1 4.5e-129 428.9 0.1 1.0 1 0 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.10 EMC82538.1 - 2.3e-14 53.9 0.2 4.3e-14 53.0 0.2 1.4 1 1 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 EMC82538.1 - 6.6e-05 23.0 0.3 0.024 14.7 0.0 2.2 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat TED_complement PF07678.14 EMC82539.1 - 6.3e-96 321.1 0.4 1.4e-95 319.9 0.1 1.7 2 0 0 2 2 2 1 A-macroglobulin TED domain MG3 PF17791.1 EMC82539.1 - 1.5e-25 89.3 3.0 5e-24 84.4 1.2 3.2 3 0 0 3 3 3 1 Macroglobulin domain MG3 A2M PF00207.22 EMC82539.1 - 3.9e-24 84.3 0.0 2.2e-23 81.9 0.0 2.4 2 0 0 2 2 2 1 Alpha-2-macroglobulin family A2M_BRD PF07703.14 EMC82539.1 - 4.1e-22 79.0 0.0 3e-18 66.5 0.0 2.9 2 0 0 2 2 2 2 Alpha-2-macroglobulin bait region domain A2M_recep PF07677.14 EMC82539.1 - 1.5e-21 76.9 2.1 5.6e-21 75.0 2.1 2.1 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain MG2 PF01835.19 EMC82539.1 - 3.7e-18 65.8 0.2 1e-16 61.1 0.0 3.3 3 0 0 3 3 3 1 MG2 domain SVA PF05326.11 EMC82539.1 - 3e-14 53.1 0.0 9.9e-14 51.4 0.0 1.9 1 0 0 1 1 1 1 Seminal vesicle autoantigen (SVA) MG4 PF17789.1 EMC82539.1 - 1.1e-10 41.5 0.0 8.5e-10 38.7 0.0 2.7 1 0 0 1 1 1 1 Macroglobulin domain MG4 Big_1 PF02369.16 EMC82539.1 - 0.2 11.7 0.6 1.2 9.2 0.0 2.7 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 1) RimK PF08443.11 EMC82540.1 - 1.2e-42 145.6 0.0 2.1e-42 144.8 0.0 1.4 2 0 0 2 2 2 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.16 EMC82540.1 - 1.1e-11 44.4 0.0 1.8e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATPgrasp_ST PF14397.6 EMC82540.1 - 6.3e-08 32.2 1.7 0.0054 16.0 0.4 3.1 1 1 1 2 2 2 2 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 EMC82540.1 - 1.1e-07 32.0 0.0 1.6e-07 31.5 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain Synapsin_C PF02750.14 EMC82540.1 - 0.00019 21.0 0.0 0.00028 20.5 0.0 1.2 1 0 0 1 1 1 1 Synapsin, ATP binding domain Rimk_N PF18030.1 EMC82540.1 - 0.00028 21.2 0.0 0.0005 20.4 0.0 1.4 1 0 0 1 1 1 1 RimK PreATP-grasp domain ATP-grasp PF02222.22 EMC82540.1 - 0.0012 18.5 0.0 0.0018 17.9 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_YheCD PF14398.6 EMC82540.1 - 0.0012 18.1 0.0 0.91 8.7 0.0 3.1 1 1 1 2 2 2 2 YheC/D like ATP-grasp Dala_Dala_lig_C PF07478.13 EMC82540.1 - 0.0057 16.2 0.0 0.03 13.9 0.0 1.9 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus CPSase_L_D2 PF02786.17 EMC82540.1 - 0.042 13.3 0.0 0.21 11.0 0.0 2.0 1 1 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain MAGP PF05507.11 EMC82541.1 - 5.9e-29 101.2 9.7 5.9e-29 101.2 9.7 1.3 2 0 0 2 2 2 1 Microfibril-associated glycoprotein (MAGP) SVWC PF15430.6 EMC82541.1 - 0.087 13.1 4.4 0.22 11.8 0.6 2.4 1 1 1 2 2 2 0 Single domain von Willebrand factor type C APOBEC2 PF18772.1 EMC82542.1 - 1.1e-69 233.9 1.4 1.3e-69 233.7 1.4 1.0 1 0 0 1 1 1 1 APOBEC2 NAD1 PF18778.1 EMC82542.1 - 3.4e-68 229.2 1.2 3.9e-68 229.0 1.2 1.0 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 APOBEC_N PF08210.11 EMC82542.1 - 2.9e-60 203.2 0.7 3.3e-60 203.0 0.7 1.0 1 0 0 1 1 1 1 APOBEC-like N-terminal domain NAD2 PF18782.1 EMC82542.1 - 2e-58 197.4 4.6 2.3e-58 197.2 4.6 1.0 1 0 0 1 1 1 1 Novel AID APOBEC clade 2 SNAD4 PF18750.1 EMC82542.1 - 6.3e-37 126.2 0.1 8.7e-37 125.7 0.1 1.2 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC3 PF18771.1 EMC82542.1 - 3.1e-35 121.3 0.2 4.1e-35 120.9 0.2 1.1 1 0 0 1 1 1 1 APOBEC3 APOBEC_C PF05240.14 EMC82542.1 - 3.7e-29 100.5 0.1 6.3e-29 99.7 0.1 1.4 1 0 0 1 1 1 1 APOBEC-like C-terminal domain APOBEC4_like PF18774.1 EMC82542.1 - 2.1e-25 89.2 0.2 2.7e-25 88.8 0.2 1.2 1 0 0 1 1 1 1 APOBEC4-like -AID/APOBEC-deaminase APOBEC4 PF18775.1 EMC82542.1 - 2.6e-21 75.5 0.0 4.4e-21 74.8 0.0 1.4 1 0 0 1 1 1 1 APOBEC4 APOBEC1 PF18769.1 EMC82542.1 - 2.9e-19 69.2 0.0 4.5e-19 68.6 0.0 1.3 1 0 0 1 1 1 1 APOBEC1 DUF2599 PF10783.9 EMC82542.1 - 0.057 14.1 0.1 0.43 11.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2599) Toxin-deaminase PF14424.6 EMC82542.1 - 0.074 13.1 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 The BURPS668_1122 family of deaminases RcbX PF02341.15 EMC82542.1 - 0.091 13.0 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 RbcX protein APOBEC4_like PF18774.1 EMC82543.1 - 2.2e-50 170.0 0.6 2.6e-50 169.8 0.6 1.0 1 0 0 1 1 1 1 APOBEC4-like -AID/APOBEC-deaminase APOBEC1 PF18769.1 EMC82543.1 - 1e-47 160.5 1.5 1.3e-47 160.2 1.5 1.1 1 0 0 1 1 1 1 APOBEC1 SNAD4 PF18750.1 EMC82543.1 - 2.9e-36 124.1 0.6 3.4e-36 123.8 0.6 1.1 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 NAD1 PF18778.1 EMC82543.1 - 6.7e-34 117.5 0.5 7.4e-34 117.3 0.5 1.0 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 APOBEC2 PF18772.1 EMC82543.1 - 4.2e-27 95.3 0.2 4.7e-27 95.2 0.2 1.0 1 0 0 1 1 1 1 APOBEC2 NAD2 PF18782.1 EMC82543.1 - 1.1e-24 87.5 0.5 1.3e-24 87.3 0.5 1.0 1 0 0 1 1 1 1 Novel AID APOBEC clade 2 APOBEC4 PF18775.1 EMC82543.1 - 1.6e-23 82.6 0.2 1.6e-23 82.6 0.2 1.7 2 0 0 2 2 2 1 APOBEC4 APOBEC_N PF08210.11 EMC82543.1 - 6.8e-22 78.2 0.1 7.4e-22 78.1 0.1 1.0 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC3 PF18771.1 EMC82543.1 - 8.3e-21 74.5 0.6 9.6e-21 74.3 0.6 1.0 1 0 0 1 1 1 1 APOBEC3 APOBEC_C PF05240.14 EMC82543.1 - 4e-14 52.3 1.8 6.3e-14 51.7 0.0 2.1 3 0 0 3 3 3 1 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.23 EMC82543.1 - 0.0021 17.9 0.0 0.0027 17.5 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region APOBEC4_like PF18774.1 EMC82544.1 - 1.5e-31 109.1 1.6 1.7e-31 108.9 1.6 1.0 1 0 0 1 1 1 1 APOBEC4-like -AID/APOBEC-deaminase NAD1 PF18778.1 EMC82544.1 - 3.5e-30 105.4 2.0 3.9e-30 105.2 2.0 1.0 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 SNAD4 PF18750.1 EMC82544.1 - 6.8e-30 103.5 2.7 7.8e-30 103.3 2.7 1.0 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC1 PF18769.1 EMC82544.1 - 2.4e-26 91.9 3.1 2.9e-26 91.6 3.1 1.1 1 0 0 1 1 1 1 APOBEC1 APOBEC4 PF18775.1 EMC82544.1 - 3.9e-26 91.0 2.2 5.7e-26 90.5 2.2 1.3 1 0 0 1 1 1 1 APOBEC4 APOBEC2 PF18772.1 EMC82544.1 - 1.1e-24 87.4 1.6 1.2e-24 87.3 1.6 1.0 1 0 0 1 1 1 1 APOBEC2 NAD2 PF18782.1 EMC82544.1 - 4.6e-21 75.7 2.1 5.1e-21 75.6 2.1 1.1 1 0 0 1 1 1 1 Novel AID APOBEC clade 2 APOBEC3 PF18771.1 EMC82544.1 - 4.7e-20 72.1 2.9 5.3e-20 71.9 2.9 1.0 1 0 0 1 1 1 1 APOBEC3 APOBEC_N PF08210.11 EMC82544.1 - 1.2e-19 70.9 0.5 1.2e-19 70.9 0.5 1.1 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC_C PF05240.14 EMC82544.1 - 3.6e-06 26.8 0.1 9.5e-06 25.5 0.1 1.7 2 0 0 2 2 2 1 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.23 EMC82544.1 - 0.0017 18.2 0.0 0.0023 17.8 0.0 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Toxin-deaminase PF14424.6 EMC82544.1 - 0.026 14.6 0.7 0.034 14.2 0.7 1.2 1 0 0 1 1 1 0 The BURPS668_1122 family of deaminases AID PF18767.1 EMC82544.1 - 0.043 13.8 0.2 0.063 13.3 0.2 1.3 1 0 0 1 1 1 0 Activation induced deaminase Homeodomain PF00046.29 EMC82545.1 - 1.4e-21 76.1 4.8 2.4e-21 75.3 4.8 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC82545.1 - 0.0016 18.3 2.0 0.01 15.7 2.0 2.4 1 1 0 1 1 1 1 Homeobox KN domain Pro-kuma_activ PF09286.11 EMC82545.1 - 0.0036 17.6 0.4 0.0094 16.3 0.4 1.7 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Homez PF11569.8 EMC82545.1 - 0.0071 15.8 0.6 0.018 14.5 0.6 1.6 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez DUF4562 PF15123.6 EMC82545.1 - 0.06 13.3 0.5 0.14 12.1 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4562) YdaS_antitoxin PF15943.5 EMC82545.1 - 0.097 12.6 0.1 0.2 11.5 0.1 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Homeodomain PF00046.29 EMC82546.1 - 1.1e-21 76.4 5.8 1.7e-21 75.8 5.8 1.3 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 EMC82546.1 - 0.0012 18.3 0.4 0.0021 17.5 0.4 1.4 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.11 EMC82546.1 - 0.0028 17.5 0.7 0.0081 16.0 0.1 2.0 2 0 0 2 2 2 1 Homeobox KN domain Pro-kuma_activ PF09286.11 EMC82546.1 - 0.0057 17.0 0.2 0.028 14.7 0.1 2.0 1 1 1 2 2 2 1 Pro-kumamolisin, activation domain YdaS_antitoxin PF15943.5 EMC82546.1 - 0.051 13.4 0.1 0.096 12.6 0.1 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT MerR_1 PF13411.6 EMC82546.1 - 0.14 12.3 0.1 1.4 9.0 0.0 2.2 2 0 0 2 2 2 0 MerR HTH family regulatory protein Sugar_tr PF00083.24 EMC82547.1 - 1e-158 528.9 29.8 1.2e-158 528.7 29.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMC82547.1 - 5.3e-22 78.2 33.7 2.1e-20 72.9 28.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_3_2 PF04550.12 EMC82547.1 - 0.32 11.6 7.2 0.067 13.7 2.3 2.5 2 1 0 2 2 2 0 Phage holin family 2 Phage_holin_2_3 PF16080.5 EMC82547.1 - 1.9 8.3 5.7 2.4 8.0 0.7 2.9 1 1 1 2 2 2 0 Bacteriophage holin family HP1 Forkhead PF00250.18 EMC82548.1 - 2.6e-27 94.9 0.1 1.1e-26 92.9 0.1 2.1 1 0 0 1 1 1 1 Forkhead domain 7tm_1 PF00001.21 EMC82549.1 - 3.4e-40 138.0 22.4 5.6e-39 134.0 22.4 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC82549.1 - 1.2e-05 25.1 13.8 1.2e-05 25.1 13.8 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 EMC82549.1 - 2.1e-05 24.0 14.0 0.0053 16.2 7.6 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 EMC82549.1 - 0.0091 15.3 11.3 0.014 14.7 9.6 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw HIG_1_N PF04588.13 EMC82549.1 - 0.027 14.7 0.3 0.096 12.9 0.3 1.9 1 0 0 1 1 1 0 Hypoxia induced protein conserved region DUF1681 PF07933.14 EMC82550.1 - 3.7e-57 192.2 0.0 4.6e-57 191.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) Lectin_C PF00059.21 EMC82552.1 - 9.7e-15 55.2 3.8 9.7e-15 55.2 3.8 1.6 1 1 1 2 2 2 1 Lectin C-type domain UL45 PF05473.12 EMC82552.1 - 0.16 11.6 3.3 0.28 10.8 3.3 1.7 1 1 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like ODV-E18 PF10717.9 EMC82552.1 - 0.51 10.2 1.5 0.87 9.5 1.5 1.3 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 TLV_coat PF00429.19 EMC82553.1 - 0.0053 15.5 0.0 0.0053 15.5 0.0 1.1 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) SdpI PF13630.6 EMC82553.1 - 0.063 13.4 0.0 0.092 12.9 0.0 1.2 1 0 0 1 1 1 0 SdpI/YhfL protein family PrmA PF06325.13 EMC82554.1 - 5.9e-09 35.7 0.0 9.5e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EMC82554.1 - 2.8e-08 34.3 0.0 5.6e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC82554.1 - 1e-06 29.3 0.0 2.4e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC82554.1 - 0.00026 20.8 0.0 0.00047 20.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC82554.1 - 0.00031 20.6 0.0 0.00074 19.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 EMC82554.1 - 0.0015 18.1 0.0 0.0027 17.2 0.0 1.4 1 0 0 1 1 1 1 Histone methylation protein DOT1 MTS PF05175.14 EMC82554.1 - 0.0017 17.9 0.0 0.0029 17.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_9 PF08003.11 EMC82554.1 - 0.0042 16.1 0.0 0.006 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_12 PF08242.12 EMC82554.1 - 0.0051 17.5 0.0 0.0088 16.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EMC82554.1 - 0.018 14.8 0.2 0.039 13.7 0.1 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_16 PF10294.9 EMC82554.1 - 0.023 14.4 0.0 0.038 13.7 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase CMAS PF02353.20 EMC82554.1 - 0.035 13.4 0.0 0.048 13.0 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 EMC82554.1 - 0.055 13.4 0.1 0.098 12.6 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase domain PRMT5_C PF17286.2 EMC82554.1 - 0.097 12.5 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 PRMT5 oligomerisation domain PRMT5 PF05185.16 EMC82554.1 - 0.11 12.4 0.2 0.22 11.4 0.2 1.5 1 1 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Methyltransf_32 PF13679.6 EMC82554.1 - 0.17 11.9 0.0 0.28 11.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Ras PF00071.22 EMC82555.1 - 1e-50 171.5 0.2 1.2e-50 171.3 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC82555.1 - 2.1e-33 115.1 0.2 2.6e-33 114.8 0.2 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC82555.1 - 5.2e-18 65.1 0.0 6e-18 64.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC82555.1 - 1.8e-10 40.9 0.1 2.3e-10 40.5 0.1 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMC82555.1 - 1.4e-06 27.9 0.0 1.6e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EMC82555.1 - 5.4e-05 22.7 0.0 6.6e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EMC82555.1 - 0.00021 20.9 0.0 0.00054 19.6 0.1 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EMC82555.1 - 0.00073 19.5 0.0 0.99 9.3 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase AAA_33 PF13671.6 EMC82555.1 - 0.0075 16.4 0.0 0.0088 16.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain FeoB_N PF02421.18 EMC82555.1 - 0.029 13.9 0.1 0.035 13.6 0.1 1.5 1 1 0 1 1 1 0 Ferrous iron transport protein B Dynamin_N PF00350.23 EMC82555.1 - 0.032 14.3 0.0 0.092 12.8 0.0 1.7 1 1 1 2 2 2 0 Dynamin family G-alpha PF00503.20 EMC82555.1 - 0.045 12.9 0.7 4.1 6.5 0.0 2.4 1 1 1 2 2 2 0 G-protein alpha subunit Septin PF00735.18 EMC82555.1 - 0.06 12.6 0.0 0.089 12.1 0.0 1.2 1 0 0 1 1 1 0 Septin AAA PF00004.29 EMC82555.1 - 0.081 13.3 0.0 0.13 12.7 0.0 1.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.9 EMC82555.1 - 0.092 12.5 0.1 2.6 7.8 0.0 2.1 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 EMC82555.1 - 0.15 11.4 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein EF-hand_1 PF00036.32 EMC82556.1 - 4.4e-09 35.3 0.1 0.00058 19.2 0.0 3.1 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EMC82556.1 - 1.3e-08 34.1 0.1 0.01 15.7 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 EMC82556.1 - 7.1e-07 29.6 0.0 7.1e-07 29.6 0.0 3.4 4 1 0 4 4 4 1 EF-hand domain pair EF-hand_8 PF13833.6 EMC82556.1 - 3.1e-05 23.7 0.1 0.00015 21.6 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 EMC82556.1 - 3.1e-05 23.2 0.1 0.024 14.1 0.0 3.3 2 0 0 2 2 2 2 EF hand DUF4407 PF14362.6 EMC82556.1 - 0.75 9.1 15.9 1.3 8.3 15.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.19 EMC82556.1 - 5.7 4.7 18.0 7.9 4.3 18.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PARP PF00644.20 EMC82557.1 - 2.2e-44 151.4 0.0 3.5e-44 150.8 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.20 EMC82557.1 - 4.1e-14 52.9 0.1 8.9e-14 51.8 0.1 1.6 1 0 0 1 1 1 1 WWE domain Tetraspanin PF00335.20 EMC82558.1 - 3.8e-55 187.1 16.2 4.4e-55 186.9 16.2 1.0 1 0 0 1 1 1 1 Tetraspanin family OppC_N PF12911.7 EMC82558.1 - 0.057 13.4 2.3 1.1 9.3 1.0 2.6 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C TadF PF16964.5 EMC82558.1 - 0.079 12.7 0.7 0.14 11.9 0.0 1.7 2 0 0 2 2 2 0 Putative tight adherence pilin protein F Baculo_11_kDa PF06143.11 EMC82558.1 - 0.71 9.5 3.6 0.39 10.3 0.7 2.0 2 0 0 2 2 2 0 Baculovirus 11 kDa family DUF2207 PF09972.9 EMC82558.1 - 1.3 7.7 10.0 2.8 6.6 7.3 2.2 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF4212 PF13937.6 EMC82558.1 - 1.6 9.2 6.6 1.3 9.4 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4212) Sigma_reg_N PF13800.6 EMC82558.1 - 4.6 7.6 6.0 0.72 10.2 1.2 2.1 2 1 1 3 3 3 0 Sigma factor regulator N-terminal DUF4834 PF16118.5 EMC82558.1 - 4.8 8.2 8.5 10 7.2 0.3 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) YBD PF17725.1 EMC82559.1 - 6.2e-94 313.7 2.3 8e-94 313.3 2.3 1.1 1 0 0 1 1 1 1 YAP binding domain TEA PF01285.18 EMC82559.1 - 2e-27 95.0 0.0 4.5e-27 93.9 0.0 1.6 1 0 0 1 1 1 1 TEA/ATTS domain AvrM_N PF18247.1 EMC82559.1 - 0.12 12.3 0.0 0.31 11.0 0.0 1.6 1 0 0 1 1 1 0 Flax-rust effector AvrM N-terminal domain MSP1a PF11670.8 EMC82559.1 - 0.29 10.4 1.0 0.48 9.7 1.0 1.2 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) TOH_N PF12549.8 EMC82559.1 - 5.4 7.0 6.9 2.9 7.9 3.3 2.3 2 0 0 2 2 2 0 Tyrosine hydroxylase N terminal Tub PF01167.18 EMC82560.1 - 1.2e-93 313.4 0.0 1.6e-93 312.9 0.0 1.2 1 0 0 1 1 1 1 Tub family Tub_N PF16322.5 EMC82560.1 - 2.1e-48 165.5 16.1 2.8e-25 90.0 6.7 2.2 1 1 1 2 2 2 2 Tubby N-terminal DUF3527 PF12043.8 EMC82560.1 - 0.1 12.2 0.0 0.23 11.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3527) RHINO PF15319.6 EMC82561.1 - 5.6e-84 282.0 10.1 6.4e-84 281.9 10.1 1.0 1 0 0 1 1 1 1 RAD9, RAD1, HUS1-interacting nuclear orphan protein Forkhead PF00250.18 EMC82562.1 - 3.9e-31 107.1 0.3 8.3e-31 106.1 0.3 1.6 1 0 0 1 1 1 1 Forkhead domain Asp_protease PF09668.10 EMC82563.1 - 8.1e-09 35.3 0.0 1.4e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 EMC82563.1 - 0.0023 18.4 0.0 0.0048 17.4 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease DMAP_binding PF06464.11 EMC82563.1 - 0.11 13.3 0.4 0.16 12.8 0.4 1.3 1 0 0 1 1 1 0 DMAP1-binding Domain Itfg2 PF15907.5 EMC82565.1 - 1.1e-164 547.3 0.3 3.5e-163 542.4 0.0 2.0 1 1 1 2 2 2 2 Integrin-alpha FG-GAP repeat-containing protein 2 BBS2_Mid PF14783.6 EMC82565.1 - 3.5e-14 52.8 0.4 0.0021 18.0 0.0 3.8 3 1 0 3 3 3 3 Ciliary BBSome complex subunit 2, middle region VCBS PF13517.6 EMC82565.1 - 2.4e-06 28.1 4.6 0.2 12.3 0.5 3.8 3 0 0 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 EMC82565.1 - 0.0055 16.8 2.1 1.6 9.0 0.2 3.0 3 0 0 3 3 3 2 FG-GAP repeat PHTB1_N PF14727.6 EMC82565.1 - 0.008 15.6 0.0 0.16 11.3 0.0 2.4 2 1 1 3 3 3 1 PTHB1 N-terminus BBS1 PF14779.6 EMC82565.1 - 0.02 14.3 2.1 10 5.4 0.0 3.5 3 1 1 4 4 4 0 Ciliary BBSome complex subunit 1 BBS2_C PF14782.6 EMC82565.1 - 0.15 10.8 0.0 11 4.7 0.0 2.8 2 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, C-terminal FKBP_C PF00254.28 EMC82566.1 - 1.3e-48 163.2 0.1 1.5e-31 108.5 0.0 2.3 2 0 0 2 2 2 2 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.28 EMC82566.1 - 1.3e-18 66.0 10.8 3.6e-09 36.1 2.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EMC82566.1 - 1.8e-14 52.6 14.4 3.9e-06 26.6 1.3 4.3 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 EMC82566.1 - 1.3e-08 34.9 3.0 0.0018 18.8 0.0 4.1 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMC82566.1 - 2.1e-08 33.7 11.4 0.00038 20.4 0.9 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EMC82566.1 - 3.6e-07 30.4 3.3 7.5e-06 26.2 2.0 2.8 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMC82566.1 - 1e-06 28.3 7.0 0.00053 19.6 0.1 3.5 2 1 1 3 3 3 2 TPR repeat FKBP_N_2 PF18023.1 EMC82566.1 - 7.4e-06 26.0 0.0 0.067 13.3 0.0 3.4 3 1 0 3 3 2 2 BDBT FKBP like N-terminal TPR_16 PF13432.6 EMC82566.1 - 1e-05 26.1 0.5 0.51 11.0 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMC82566.1 - 1.2e-05 25.7 4.0 0.0075 16.8 1.7 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat PknG_TPR PF16918.5 EMC82566.1 - 1.7e-05 23.7 0.7 2.5e-05 23.2 0.7 1.2 1 0 0 1 1 1 1 Protein kinase G tetratricopeptide repeat TPR_9 PF13371.6 EMC82566.1 - 0.00055 20.0 0.0 0.0011 19.0 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 EMC82566.1 - 0.00055 19.8 3.3 0.078 13.0 0.3 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EMC82566.1 - 0.0007 20.2 0.2 0.13 13.1 0.0 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMC82566.1 - 0.0012 18.9 0.3 0.0012 18.9 0.3 3.1 3 1 1 4 4 3 1 Fis1 C-terminal tetratricopeptide repeat DUF3856 PF12968.7 EMC82566.1 - 0.0075 16.3 0.5 0.018 15.1 0.5 1.6 1 0 0 1 1 1 1 Domain of Unknown Function (DUF3856) TPR_17 PF13431.6 EMC82566.1 - 0.021 15.2 6.1 0.28 11.7 0.2 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat GDPD PF03009.17 EMC82566.1 - 0.023 14.5 1.3 0.024 14.4 0.2 1.5 2 0 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family ANAPC3 PF12895.7 EMC82566.1 - 0.046 13.9 9.5 8.3 6.7 0.4 3.2 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 EMC82566.1 - 0.13 12.0 5.2 0.11 12.1 2.9 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat-like domain Alkyl_sulf_dimr PF14863.6 EMC82566.1 - 0.97 9.9 5.4 13 6.2 0.1 2.8 1 1 1 2 2 2 0 Alkyl sulfatase dimerisation Efg1 PF10153.9 EMC82566.1 - 6 7.3 10.2 0.26 11.6 2.6 2.3 2 0 0 2 2 2 0 rRNA-processing protein Efg1 Lectin_C PF00059.21 EMC82567.1 - 2.1e-14 54.1 1.2 2.7e-14 53.8 1.2 1.1 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 EMC82567.1 - 0.025 14.2 0.1 0.034 13.8 0.1 1.2 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Aldo_ket_red PF00248.21 EMC82568.1 - 3.1e-49 167.8 0.0 6.1e-49 166.8 0.0 1.5 1 1 0 1 1 1 1 Aldo/keto reductase family DUF1456 PF07308.13 EMC82568.1 - 0.054 13.8 0.0 0.3 11.4 0.0 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1456) Dev_Cell_Death PF10539.9 EMC82568.1 - 0.091 12.6 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 Development and cell death domain DUF1187 PF06688.11 EMC82568.1 - 0.11 12.8 4.5 36 4.8 0.0 4.7 5 0 0 5 5 5 0 Protein of unknown function (DUF1187) His_Phos_1 PF00300.22 EMC82570.1 - 3.4e-33 115.0 0.0 3.5e-27 95.4 0.0 2.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) DUF1884 PF08967.10 EMC82571.1 - 0.00059 20.0 12.7 18 5.7 0.1 6.0 1 1 6 7 7 7 4 Domain of unknown function (DUF1884) Bacillus_HBL PF05791.11 EMC82571.1 - 0.00093 19.1 11.9 3.8 7.3 0.5 4.9 1 1 5 6 6 6 4 Bacillus haemolytic enterotoxin (HBL) Vault_3 PF17795.1 EMC82571.1 - 0.0024 17.9 2.9 1.2e+02 2.8 0.0 6.4 1 1 4 6 6 6 0 Major Vault Protein Repeat domain TM_helix PF05552.12 EMC82571.1 - 0.12 12.4 7.9 91 3.1 0.1 6.2 2 2 5 8 8 8 0 Conserved TM helix EF-hand_1 PF00036.32 EMC82572.1 - 1.6e-14 52.3 3.0 3e-05 23.3 0.1 4.7 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EMC82572.1 - 2.5e-13 48.8 6.3 0.00017 21.3 0.1 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 EMC82572.1 - 7.3e-11 42.4 4.0 0.00066 20.1 0.1 3.8 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EMC82572.1 - 1.1e-07 31.0 0.1 0.013 14.9 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_10 PF14788.6 EMC82572.1 - 1.3e-06 28.2 0.9 0.043 13.7 0.0 4.4 4 0 0 4 4 4 1 EF hand GPHH PF16905.5 EMC82572.1 - 0.0073 16.1 0.0 0.02 14.7 0.0 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated SPARC_Ca_bdg PF10591.9 EMC82572.1 - 0.0091 16.3 3.1 0.49 10.7 2.9 3.0 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 EMC82572.1 - 0.043 13.7 0.2 11 6.0 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain pair Dockerin_1 PF00404.18 EMC82572.1 - 0.051 13.8 0.0 0.42 10.9 0.0 2.5 4 0 0 4 4 4 0 Dockerin type I domain Fib_alpha PF08702.10 EMC82572.1 - 0.055 13.6 0.3 3.5 7.8 0.0 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Caleosin PF05042.13 EMC82572.1 - 0.091 12.7 0.8 1.2 9.1 0.0 2.7 3 0 0 3 3 3 0 Caleosin related protein PDZ PF00595.24 EMC82573.1 - 1.9e-10 40.9 0.0 3.3e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PB1 PF00564.24 EMC82573.1 - 4.7e-10 39.3 0.0 1e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 PB1 domain PDZ_6 PF17820.1 EMC82573.1 - 4.7e-09 36.0 0.0 9.3e-09 35.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain DUF5063 PF16702.5 EMC82574.1 - 0.019 15.3 0.0 0.023 15.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5063) BLOC1_2 PF10046.9 EMC82574.1 - 0.032 14.5 0.3 0.29 11.4 0.0 2.0 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spc29 PF17082.5 EMC82574.1 - 0.048 13.5 0.1 0.058 13.2 0.1 1.2 1 0 0 1 1 1 0 Spindle Pole Component 29 AIP3 PF03915.13 EMC82574.1 - 0.057 12.5 0.2 0.095 11.8 0.2 1.3 1 0 0 1 1 1 0 Actin interacting protein 3 CAP PF00188.26 EMC82575.1 - 2.4e-22 80.1 0.8 3.1e-22 79.8 0.8 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Ifi-6-16 PF06140.13 EMC82576.1 - 1.4e-23 82.6 22.8 1e-12 47.8 5.6 2.0 1 1 1 2 2 2 2 Interferon-induced 6-16 family SMP PF04927.12 EMC82576.1 - 0.1 13.1 2.1 1.5 9.3 0.2 2.3 2 0 0 2 2 2 0 Seed maturation protein SoxE PF06525.11 EMC82576.1 - 0.14 11.6 2.7 0.25 10.8 0.5 2.0 2 0 0 2 2 2 0 Sulfocyanin (SoxE) domain Glycos_transf_1 PF00534.20 EMC82577.1 - 3.6e-39 134.1 0.0 5.6e-39 133.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EMC82577.1 - 5.3e-18 65.7 0.0 8.9e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EMC82577.1 - 1.8e-06 28.0 0.0 3.8e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 EMC82577.1 - 0.00013 22.2 0.0 0.00033 21.0 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EMC82577.1 - 0.012 16.1 0.2 0.027 14.9 0.1 1.6 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain MINDY_DUB PF04424.13 EMC82577.1 - 0.22 11.5 0.7 1.7 8.7 0.3 2.5 1 1 1 2 2 2 0 MINDY deubiquitinase Sec61_beta PF03911.16 EMC82578.1 - 1.1e-19 70.2 0.0 1.4e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 Sec61beta family zf-C4 PF00105.18 EMC82579.1 - 3.6e-31 107.4 18.3 6.4e-31 106.6 18.3 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 EMC82579.1 - 9.6e-19 67.8 0.1 1.7e-18 67.0 0.1 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor BAAT_C PF08840.11 EMC82580.1 - 0.15 12.0 0.0 0.17 11.8 0.0 1.1 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Penicillinase_R PF03965.16 EMC82580.1 - 0.19 12.1 0.0 0.21 11.9 0.0 1.2 1 0 0 1 1 1 0 Penicillinase repressor SNARE PF05739.19 EMC82581.1 - 7.8e-06 25.8 0.1 1.8e-05 24.6 0.1 1.7 1 0 0 1 1 1 1 SNARE domain Phage_holin_3_6 PF07332.11 EMC82581.1 - 0.0012 18.9 2.0 0.0028 17.7 2.0 1.7 1 1 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III RseC_MucC PF04246.12 EMC82581.1 - 0.032 14.2 0.0 0.051 13.5 0.0 1.3 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC ADD_DNMT3 PF17980.1 EMC82581.1 - 0.18 11.8 0.3 14 5.8 0.0 2.5 2 0 0 2 2 2 0 Cysteine rich ADD domain in DNMT3 IncD PF17628.2 EMC82581.1 - 0.22 11.3 4.1 0.55 10.0 4.1 1.6 1 1 0 1 1 1 0 Inclusion membrane protein D SlyX PF04102.12 EMC82581.1 - 0.39 11.4 4.8 0.47 11.1 0.2 2.8 3 0 0 3 3 3 0 SlyX DUF3169 PF11368.8 EMC82581.1 - 5.3 6.5 5.4 49 3.3 5.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3169) Rick_17kDa_Anti PF05433.15 EMC82581.1 - 5.4 7.0 19.6 9.2 6.2 19.6 1.4 1 0 0 1 1 1 0 Glycine zipper 2TM domain Thioredoxin_6 PF13848.6 EMC82582.1 - 8.1e-48 162.8 0.2 9.8e-44 149.5 0.1 2.4 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin PF00085.20 EMC82582.1 - 3.3e-21 75.2 0.0 8.4e-21 73.9 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin Calsequestrin PF01216.17 EMC82582.1 - 8.2e-08 31.7 0.1 1.4e-07 30.9 0.1 1.3 1 0 0 1 1 1 1 Calsequestrin OST3_OST6 PF04756.13 EMC82582.1 - 2.6e-05 23.7 0.0 4.3e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EMC82582.1 - 0.00047 20.6 0.1 0.0018 18.7 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin-like domain HyaE PF07449.11 EMC82582.1 - 0.00068 19.6 0.0 0.0021 18.0 0.0 1.8 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Thioredoxin_8 PF13905.6 EMC82582.1 - 0.0054 17.0 0.2 0.091 13.1 0.1 2.6 1 1 1 2 2 2 1 Thioredoxin-like MBT PF02820.18 EMC82584.1 - 1.1e-23 83.4 0.1 3.2e-23 81.8 0.1 1.9 1 0 0 1 1 1 1 mbt repeat STIMATE PF12400.8 EMC82585.1 - 1.8e-33 115.8 10.4 2.8e-33 115.1 10.4 1.3 1 0 0 1 1 1 1 STIMATE family Vpu PF00558.19 EMC82585.1 - 0.26 11.1 2.0 0.35 10.7 0.0 2.3 3 0 0 3 3 3 0 Vpu protein TB2_DP1_HVA22 PF03134.19 EMC82585.1 - 3.5 7.6 6.5 0.52 10.3 0.9 2.4 1 1 0 2 2 2 0 TB2/DP1, HVA22 family ITI_HC_C PF06668.12 EMC82586.1 - 1.4e-72 243.3 0.4 3.2e-72 242.2 0.4 1.6 1 0 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus VIT PF08487.10 EMC82586.1 - 2.3e-29 101.8 1.0 5e-29 100.8 1.0 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.28 EMC82586.1 - 2.4e-21 76.8 0.3 4.9e-21 75.8 0.3 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EMC82586.1 - 1.6e-18 67.1 0.0 2.5e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EMC82586.1 - 5.7e-13 49.5 0.2 1.9e-12 47.7 0.1 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 EMC82586.1 - 7.5e-05 22.2 0.0 0.00025 20.5 0.0 1.8 2 0 0 2 2 2 1 VWA domain containing CoxE-like protein ATP-synt PF00231.19 EMC82587.1 - 4.3e-81 272.7 2.3 4.8e-81 272.5 2.3 1.0 1 0 0 1 1 1 1 ATP synthase PHD PF00628.29 EMC82588.1 - 9.1e-11 41.5 7.2 2.2e-10 40.3 7.2 1.7 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EMC82588.1 - 0.0025 17.3 2.2 0.0025 17.3 2.2 2.3 2 0 0 2 2 2 1 PHD-finger RNA_pol_Rpc4 PF05132.14 EMC82588.1 - 0.0035 17.8 13.8 0.0035 17.8 13.8 5.9 5 1 0 5 5 5 1 RNA polymerase III RPC4 DUF4471 PF14740.6 EMC82588.1 - 0.062 12.5 0.1 0.062 12.5 0.1 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4471) GATA PF00320.27 EMC82589.1 - 2e-29 100.9 19.4 1.1e-14 53.7 5.2 2.4 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 EMC82589.1 - 1.8e-05 24.1 7.9 0.023 14.2 0.7 2.4 2 0 0 2 2 2 2 TFIIB zinc-binding DUF2387 PF09526.10 EMC82589.1 - 0.014 15.5 5.4 2.7 8.2 0.6 3.3 1 1 2 3 3 3 0 Probable metal-binding protein (DUF2387) Zn-ribbon_8 PF09723.10 EMC82589.1 - 0.019 15.0 2.6 2.6 8.2 0.1 2.8 2 1 0 2 2 2 0 Zinc ribbon domain ArfGap PF01412.18 EMC82589.1 - 0.046 13.8 8.4 0.1 12.7 0.4 2.7 1 1 1 2 2 2 0 Putative GTPase activating protein for Arf Auto_anti-p27 PF06677.12 EMC82589.1 - 0.083 13.1 5.2 1.2 9.4 0.4 2.5 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Prim_Zn_Ribbon PF08273.12 EMC82589.1 - 0.43 10.9 9.4 0.37 11.1 2.1 2.8 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase DZR PF12773.7 EMC82589.1 - 1.7 8.7 12.8 6.5 6.9 2.4 3.1 1 1 1 2 2 2 0 Double zinc ribbon OrfB_Zn_ribbon PF07282.11 EMC82589.1 - 7 6.7 13.0 7.5 6.6 2.7 3.1 3 0 0 3 3 3 0 Putative transposase DNA-binding domain Elf1 PF05129.13 EMC82589.1 - 7.1 6.8 8.3 11 6.1 0.3 2.8 2 1 1 3 3 2 0 Transcription elongation factor Elf1 like eIF-5_eIF-2B PF01873.17 EMC82589.1 - 8.7 6.2 9.1 15 5.4 1.2 2.7 3 0 0 3 3 3 0 Domain found in IF2B/IF5 Vps36-NZF-N PF16988.5 EMC82589.1 - 9.4 5.7 8.7 1.3 8.5 0.4 3.0 2 1 1 3 3 3 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain GETHR PF05671.11 EMC82590.1 - 0.007 15.7 244.7 5.8 6.4 20.3 11.5 1 1 9 10 10 10 7 GETHR pentapeptide repeat (5 copies) Lig_chan PF00060.26 EMC82591.1 - 8.1e-44 149.1 0.3 1.3e-43 148.4 0.3 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 EMC82591.1 - 4.8e-40 136.3 0.0 8.2e-40 135.6 0.0 1.4 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 EMC82591.1 - 1.4e-26 93.4 0.0 2.4e-26 92.6 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 ANF_receptor PF01094.28 EMC82591.1 - 1.5e-19 70.3 0.0 2.8e-19 69.4 0.0 1.5 1 0 0 1 1 1 1 Receptor family ligand binding region ANF_receptor PF01094.28 EMC82592.1 - 3.9e-09 36.1 0.0 4.8e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region TrmO PF01980.16 EMC82592.1 - 0.2 11.9 0.0 0.28 11.4 0.0 1.2 1 0 0 1 1 1 0 tRNA-methyltransferase O WAPL PF07814.13 EMC82593.1 - 1.5e-117 392.5 7.9 2.5e-117 391.8 7.9 1.4 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin Wap1 PF16997.5 EMC82593.1 - 0.00027 20.2 4.2 0.0049 16.1 0.1 2.5 2 1 0 2 2 2 2 Wap1 domain 7tm_1 PF00001.21 EMC82594.1 - 3.8e-53 180.5 17.1 4.9e-53 180.1 17.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC82594.1 - 1.4e-13 50.8 17.1 1.9e-13 50.4 17.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC82594.1 - 8.4e-09 35.4 20.0 1.3e-08 34.8 20.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 EMC82594.1 - 0.00012 21.5 9.8 0.00019 20.9 9.8 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 EMC82594.1 - 0.00051 19.9 8.4 0.00051 19.9 8.4 2.5 2 1 0 2 2 2 1 Olfactory receptor Git3 PF11710.8 EMC82594.1 - 0.031 14.0 13.2 0.068 12.9 13.2 1.5 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 LIM PF00412.22 EMC82595.1 - 6.3e-37 125.6 31.4 1.9e-13 50.4 4.4 3.3 3 0 0 3 3 3 3 LIM domain DUF4749 PF15936.5 EMC82595.1 - 9e-23 81.2 0.2 9e-23 81.2 0.2 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4749) RWD PF05773.22 EMC82596.1 - 9.8e-25 87.1 0.0 1.8e-24 86.2 0.0 1.5 1 0 0 1 1 1 1 RWD domain IBR PF01485.21 EMC82596.1 - 6.8e-11 42.2 3.5 6.8e-11 42.2 3.5 3.3 2 1 1 3 3 3 1 IBR domain, a half RING-finger domain zf-RING_5 PF14634.6 EMC82596.1 - 0.00015 21.6 15.5 0.00015 21.6 15.5 2.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 EMC82596.1 - 0.0023 18.2 12.4 0.0023 18.2 12.4 2.7 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 EMC82596.1 - 0.011 15.8 11.5 0.011 15.8 11.5 2.5 2 0 0 2 2 2 0 RING-type zinc-finger COLFI PF01410.18 EMC82599.1 - 3.4e-15 56.0 0.0 3.8e-15 55.8 0.0 1.0 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Ras PF00071.22 EMC82600.1 - 1.2e-48 164.8 0.1 1.3e-48 164.7 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC82600.1 - 2e-33 115.1 0.1 2.4e-33 114.9 0.1 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC82600.1 - 1.1e-12 47.8 0.0 1.4e-12 47.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC82600.1 - 3.5e-05 23.4 0.0 0.0009 18.8 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EMC82600.1 - 9.6e-05 22.4 0.0 0.00012 22.2 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMC82600.1 - 0.00014 21.4 0.0 0.00016 21.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EMC82600.1 - 0.0023 17.4 0.0 0.0035 16.8 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 EMC82600.1 - 0.004 16.7 0.1 0.0065 16.0 0.1 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region ATPase PF06745.13 EMC82600.1 - 0.018 14.4 0.1 0.025 13.9 0.1 1.2 1 0 0 1 1 1 0 KaiC Septin PF00735.18 EMC82600.1 - 0.021 14.1 0.0 0.026 13.8 0.0 1.1 1 0 0 1 1 1 0 Septin AAA_16 PF13191.6 EMC82600.1 - 0.033 14.6 0.0 0.05 14.0 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 EMC82600.1 - 0.034 14.6 0.1 0.22 12.0 0.1 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EMC82600.1 - 0.044 13.5 0.1 0.13 12.0 0.0 1.6 1 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EMC82600.1 - 0.045 14.0 0.1 0.097 12.9 0.1 1.6 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EMC82600.1 - 0.048 13.6 0.0 0.055 13.4 0.0 1.1 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 EMC82600.1 - 0.068 13.1 0.2 2.2 8.1 0.1 2.3 1 1 2 3 3 3 0 RsgA GTPase UvrD-helicase PF00580.21 EMC82600.1 - 0.074 12.6 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain ATP_bind_1 PF03029.17 EMC82600.1 - 0.082 12.7 0.0 8.7 6.0 0.1 2.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein DUF2075 PF09848.9 EMC82600.1 - 0.11 11.7 0.1 0.14 11.3 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 EMC82600.1 - 0.11 12.4 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 EMC82600.1 - 0.13 12.3 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Stanniocalcin PF03298.13 EMC82601.1 - 4.2e-84 280.9 13.6 5.6e-84 280.5 13.6 1.1 1 0 0 1 1 1 1 Stanniocalcin family Homeodomain PF00046.29 EMC82602.1 - 7e-20 70.6 4.3 7e-20 70.6 4.3 1.8 2 0 0 2 2 2 1 Homeodomain Homez PF11569.8 EMC82602.1 - 0.075 12.5 0.3 0.19 11.2 0.3 1.6 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.11 EMC82602.1 - 1.1 9.2 3.5 0.64 10.0 0.1 2.4 3 0 0 3 3 3 0 Homeobox KN domain Sec20 PF03908.13 EMC82603.1 - 6.3e-33 112.6 7.9 6.9e-33 112.4 4.4 2.1 2 0 0 2 2 2 1 Sec20 DUF2777 PF10949.8 EMC82603.1 - 0.0022 17.7 3.0 0.0026 17.4 2.5 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2777) Sec16 PF12932.7 EMC82603.1 - 0.05 14.2 2.4 0.064 13.8 0.1 2.1 2 1 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region DUF2721 PF11026.8 EMC82603.1 - 0.19 11.6 5.4 1.3 9.0 0.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2721) ThiG PF05690.14 EMC82603.1 - 0.3 10.4 3.5 1.2 8.4 0.9 2.0 1 1 1 2 2 2 0 Thiazole biosynthesis protein ThiG DUF1664 PF07889.12 EMC82603.1 - 0.32 11.1 9.1 2.7 8.0 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) 7tm_6 PF02949.20 EMC82603.1 - 0.58 9.2 6.3 0.088 11.9 2.9 1.6 2 1 0 2 2 2 0 7tm Odorant receptor Tombus_P33 PF08500.10 EMC82603.1 - 0.87 9.5 3.6 0.58 10.1 0.8 1.9 1 1 0 2 2 2 0 Tombusvirus p33 Med9 PF07544.13 EMC82603.1 - 1.1 9.4 13.2 5.2 7.2 1.0 2.6 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 ACCA PF03255.14 EMC82603.1 - 1.3 8.9 10.9 0.21 11.5 3.5 2.1 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Cep57_MT_bd PF06657.13 EMC82603.1 - 1.7 9.1 12.8 0.18 12.3 2.3 2.5 2 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 DUF4337 PF14235.6 EMC82603.1 - 1.7 8.7 15.5 1.4 9.0 4.4 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4337) bZIP_1 PF00170.21 EMC82604.1 - 0.0041 17.2 2.8 0.0041 17.2 2.8 2.8 3 0 0 3 3 3 1 bZIP transcription factor bZIP_2 PF07716.15 EMC82604.1 - 0.017 15.2 2.3 0.017 15.2 2.3 2.1 2 0 0 2 2 2 0 Basic region leucine zipper TFIIA PF03153.13 EMC82604.1 - 0.29 11.1 15.1 0.56 10.1 15.1 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ATP_synt_H PF05493.13 EMC82605.1 - 3.8e-05 24.0 0.1 4.9e-05 23.7 0.1 1.2 1 0 0 1 1 1 1 ATP synthase subunit H Ribosomal_L26 PF16906.5 EMC82606.1 - 9.1e-44 147.8 5.8 1.2e-43 147.4 5.8 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 EMC82606.1 - 6.9e-08 32.2 5.9 2.2e-07 30.6 5.9 2.0 1 1 0 1 1 1 1 KOW motif BLYB PF05289.11 EMC82606.1 - 0.033 14.4 1.9 0.055 13.7 1.9 1.4 1 0 0 1 1 1 0 Borrelia hemolysin accessory protein COPIIcoated_ERV PF07970.12 EMC82607.1 - 1.3e-36 126.6 0.1 2.2e-36 125.8 0.1 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EMC82607.1 - 8.4e-36 122.2 0.0 8.4e-36 122.2 0.0 1.7 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Neuralized PF07177.12 EMC82608.1 - 1.3e-88 294.6 0.0 1.6e-44 151.6 0.0 2.5 3 0 0 3 3 3 2 Neuralized zf-C3HC4_3 PF13920.6 EMC82608.1 - 4.9e-13 48.7 13.3 1.2e-12 47.4 13.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC82608.1 - 2.4e-05 24.1 12.5 6.2e-05 22.8 12.5 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EMC82608.1 - 0.016 15.1 13.9 0.04 13.9 13.9 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EMC82608.1 - 0.12 12.3 15.4 0.26 11.2 15.4 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) UBD PF16455.5 EMC82610.1 - 5e-39 132.7 0.0 7.1e-39 132.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-binding domain ubiquitin PF00240.23 EMC82610.1 - 7.9e-12 44.8 0.0 1.3e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EMC82610.1 - 0.00015 21.6 0.0 0.00021 21.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like 7tm_1 PF00001.21 EMC82611.1 - 6.9e-77 258.3 11.4 8.6e-77 258.0 11.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC82611.1 - 1e-15 57.9 14.7 1.4e-15 57.4 14.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC82611.1 - 3.1e-12 46.7 13.7 3.1e-12 46.7 13.7 1.5 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC82611.1 - 2.8e-09 37.1 13.5 1e-08 35.3 9.1 2.1 2 0 0 2 2 2 2 Olfactory receptor TPR_12 PF13424.6 EMC82612.1 - 2.9e-12 46.7 46.4 3.8e-06 27.1 2.3 7.7 6 1 1 7 7 7 4 Tetratricopeptide repeat SH3_2 PF07653.17 EMC82612.1 - 1.5e-08 34.1 0.0 0.0002 21.0 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SNAP PF14938.6 EMC82612.1 - 9.1e-06 25.3 4.3 1.8e-05 24.3 0.5 2.8 3 1 0 3 3 3 1 Soluble NSF attachment protein, SNAP TPR_8 PF13181.6 EMC82612.1 - 3.7e-05 23.6 28.4 3.1 8.2 0.3 10.3 10 1 1 11 11 11 3 Tetratricopeptide repeat SH3_1 PF00018.28 EMC82612.1 - 4.3e-05 23.0 0.2 0.035 13.7 0.0 2.6 2 0 0 2 2 2 2 SH3 domain TPR_1 PF00515.28 EMC82612.1 - 6.4e-05 22.6 31.7 0.00015 21.4 0.1 8.6 8 1 1 9 9 9 2 Tetratricopeptide repeat SH3_9 PF14604.6 EMC82612.1 - 0.0043 16.9 0.1 2 8.3 0.0 3.0 3 0 0 3 3 3 2 Variant SH3 domain TPR_2 PF07719.17 EMC82612.1 - 0.0097 16.0 0.1 0.0097 16.0 0.1 9.9 10 1 1 11 11 11 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMC82612.1 - 0.087 12.9 19.7 2.8 8.2 0.1 7.9 7 1 1 8 8 8 0 Tetratricopeptide repeat PH PF00169.29 EMC82613.1 - 2.1e-18 66.8 0.1 7.5e-08 32.8 0.0 2.4 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 EMC82613.1 - 0.0034 17.8 0.1 0.64 10.5 0.0 2.8 2 0 0 2 2 2 1 Pleckstrin homology domain Sharpin_PH PF16764.5 EMC82613.1 - 0.0037 17.0 0.0 0.0084 15.9 0.0 1.5 1 0 0 1 1 1 1 Sharpin PH domain PH_9 PF15410.6 EMC82613.1 - 0.07 13.5 0.1 22 5.5 0.0 2.8 2 1 0 2 2 2 0 Pleckstrin homology domain GrpE PF01025.19 EMC82614.1 - 1.1e-41 142.3 0.0 1.3e-41 142.1 0.0 1.0 1 0 0 1 1 1 1 GrpE DUF2408 PF10303.9 EMC82614.1 - 0.0014 19.2 0.2 0.002 18.7 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2408) CLZ PF16526.5 EMC82614.1 - 0.015 15.7 1.2 0.42 11.0 0.1 2.2 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Laminin_I PF06008.14 EMC82614.1 - 0.04 13.6 0.1 0.051 13.3 0.1 1.1 1 0 0 1 1 1 0 Laminin Domain I DUF4525 PF15027.6 EMC82614.1 - 0.12 12.1 0.1 0.2 11.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4525) Prenylcys_lyase PF07156.14 EMC82615.1 - 1.4e-134 448.8 0.0 1.7e-134 448.5 0.0 1.1 1 0 0 1 1 1 1 Prenylcysteine lyase Amino_oxidase PF01593.24 EMC82615.1 - 0.00088 18.7 0.0 0.0014 18.0 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase IL17 PF06083.11 EMC82616.1 - 5.9e-30 103.6 1.7 8.9e-30 103.0 1.7 1.3 1 0 0 1 1 1 1 Interleukin-17 Pkinase PF00069.25 EMC82617.1 - 1.4e-24 86.8 0.0 3e-24 85.8 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC82617.1 - 5.8e-12 45.5 0.0 1.9e-11 43.7 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC82617.1 - 2.3e-10 39.9 0.0 3.4e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 EMC82617.1 - 0.022 13.7 0.1 0.036 13.0 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase ABC1 PF03109.16 EMC82617.1 - 0.11 12.7 0.0 0.58 10.3 0.0 2.2 2 0 0 2 2 2 0 ABC1 family RhoGEF PF00621.20 EMC82618.1 - 6.7e-36 124.2 0.9 1e-35 123.7 0.9 1.3 1 0 0 1 1 1 1 RhoGEF domain UvrB PF12344.8 EMC82618.1 - 0.16 11.8 1.0 0.35 10.7 1.0 1.5 1 0 0 1 1 1 0 Ultra-violet resistance protein B SH3_2 PF07653.17 EMC82619.1 - 1.6e-05 24.5 0.0 2.4e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain LAP2alpha PF11560.8 EMC82619.1 - 0.02 14.3 0.0 0.026 14.0 0.0 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 2 alpha BNIP3 PF06553.12 EMC82623.1 - 3.3e-49 167.2 0.1 3.8e-49 167.0 0.1 1.0 1 0 0 1 1 1 1 BNIP3 JAKMIP_CC3 PF16034.5 EMC82624.1 - 1.7e-84 282.8 21.6 1.7e-84 282.8 21.6 7.0 5 2 2 7 7 7 1 JAKMIP CC3 domain Coat_F PF07875.12 EMC82624.1 - 0.45 10.8 5.3 0.1 12.8 0.5 2.6 2 0 0 2 2 2 0 Coat F domain PWWP PF00855.17 EMC82626.1 - 6.7e-15 55.3 0.4 6.7e-15 55.3 0.4 1.9 2 0 0 2 2 2 1 PWWP domain Planc_extracel PF07595.12 EMC82626.1 - 2.6 8.0 5.7 25 4.9 1.6 2.7 2 0 0 2 2 2 0 Planctomycete extracellular TLE_N PF03920.15 EMC82627.1 - 1.6e-64 215.9 7.8 2.1e-64 215.4 7.8 1.2 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain HALZ PF02183.18 EMC82627.1 - 0.039 14.2 0.2 0.076 13.2 0.2 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper ELM2 PF01448.24 EMC82629.1 - 2.5e-11 44.2 0.1 1.1e-10 42.1 0.1 2.2 1 0 0 1 1 1 1 ELM2 domain Myb_DNA-binding PF00249.31 EMC82629.1 - 8.6e-07 29.1 2.0 1.1e-06 28.7 0.6 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain DUF2002 PF09400.10 EMC82629.1 - 0.048 13.7 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2002) MFS_1 PF07690.16 EMC82630.1 - 9.5e-23 80.7 25.7 6.1e-19 68.2 20.9 2.6 2 1 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EMC82630.1 - 0.00083 18.3 12.7 1 8.1 0.2 3.5 2 1 1 3 3 3 3 MFS_1 like family Sugar_tr PF00083.24 EMC82630.1 - 0.0028 16.6 8.5 0.0047 15.9 6.5 2.1 2 1 0 2 2 2 1 Sugar (and other) transporter UQ_con PF00179.26 EMC82631.1 - 2.8e-43 146.9 0.0 3.7e-43 146.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EMC82631.1 - 0.024 14.3 0.0 0.075 12.7 0.0 1.8 1 1 0 1 1 1 0 Prokaryotic E2 family B Ig_3 PF13927.6 EMC82632.1 - 1.8e-17 63.7 8.0 6.8e-13 49.0 0.4 3.6 3 1 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 EMC82632.1 - 7.4e-14 51.9 3.1 6.2e-08 32.9 0.3 3.4 2 1 1 3 3 3 3 Immunoglobulin domain I-set PF07679.16 EMC82632.1 - 2e-13 50.2 0.3 1.4e-08 34.7 0.0 3.6 3 1 1 4 4 4 2 Immunoglobulin I-set domain V-set PF07686.17 EMC82632.1 - 2.4e-09 37.3 1.7 0.0037 17.4 0.3 4.4 3 2 0 3 3 3 3 Immunoglobulin V-set domain ig PF00047.25 EMC82632.1 - 1e-07 32.0 1.1 0.0016 18.6 0.1 3.7 3 1 0 3 3 3 2 Immunoglobulin domain Ig_5 PF16681.5 EMC82632.1 - 0.00067 20.0 0.4 1 9.8 0.0 3.5 3 1 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 EMC82632.1 - 0.0023 18.1 1.3 17 5.7 0.2 3.8 3 1 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 EMC82632.1 - 0.0039 16.7 0.0 12 5.6 0.0 3.7 3 0 0 3 3 3 2 Immunoglobulin domain Orthoreo_P10 PF07204.11 EMC82632.1 - 0.025 14.5 0.0 0.048 13.6 0.0 1.4 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 cNMP_binding PF00027.29 EMC82633.1 - 1.3e-18 66.9 0.0 2.4e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans PF00520.31 EMC82633.1 - 7.3e-18 64.7 12.0 2.5e-15 56.4 6.9 2.3 2 0 0 2 2 2 2 Ion transport protein Ion_trans_N PF08412.10 EMC82633.1 - 2.1e-08 33.6 0.0 4.4e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 Ion transport protein N-terminal Ion_trans_2 PF07885.16 EMC82633.1 - 0.0038 17.1 0.2 0.0038 17.1 0.2 2.3 3 0 0 3 3 3 1 Ion channel RNA_pol PF00940.19 EMC82634.1 - 5e-162 539.5 0.0 6.5e-162 539.1 0.0 1.1 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 EMC82634.1 - 4.2e-53 180.9 0.0 6.9e-53 180.2 0.0 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal PPR_3 PF13812.6 EMC82634.1 - 5.8e-05 23.1 0.0 0.00015 21.7 0.0 1.7 1 0 0 1 1 1 1 Pentatricopeptide repeat domain PPR_2 PF13041.6 EMC82634.1 - 0.00075 19.6 0.0 0.002 18.3 0.0 1.7 1 0 0 1 1 1 1 PPR repeat family CARD PF00619.21 EMC82634.1 - 0.08 13.0 0.3 9.3 6.4 0.0 2.9 2 0 0 2 2 2 0 Caspase recruitment domain PPR PF01535.20 EMC82634.1 - 0.19 12.1 0.1 0.72 10.2 0.1 2.1 1 0 0 1 1 1 0 PPR repeat zf-RING_2 PF13639.6 EMC82635.1 - 8.9e-14 51.6 7.2 8.9e-14 51.6 7.2 1.6 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC82635.1 - 3e-09 36.6 7.0 3e-09 36.6 7.0 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EMC82635.1 - 1.3e-08 34.4 1.8 1.3e-08 34.4 1.8 1.8 2 0 0 2 2 1 1 RING-like zinc finger zf-rbx1 PF12678.7 EMC82635.1 - 9.2e-08 32.3 7.9 9.2e-08 32.3 7.9 2.0 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EMC82635.1 - 1.3e-07 31.5 5.0 1.6e-07 31.2 2.5 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EMC82635.1 - 5.5e-07 29.4 5.9 5.5e-07 29.4 5.9 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC82635.1 - 6e-07 29.3 5.0 6e-07 29.3 5.0 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EMC82635.1 - 1.6e-06 27.8 2.6 1.6e-06 27.8 2.6 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EMC82635.1 - 4.5e-05 23.4 3.7 0.00013 22.0 3.6 1.7 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EMC82635.1 - 8.9e-05 22.3 8.3 8.9e-05 22.3 8.3 2.5 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 zf-Nse PF11789.8 EMC82635.1 - 0.0043 16.8 3.5 0.0097 15.7 3.5 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zinc_ribbon_9 PF14369.6 EMC82635.1 - 0.0056 16.9 0.5 0.0056 16.9 0.5 3.1 3 0 0 3 3 3 1 zinc-ribbon Zn_ribbon_17 PF17120.5 EMC82635.1 - 0.0067 16.0 4.2 0.0067 16.0 4.2 1.6 2 0 0 2 2 1 1 Zinc-ribbon, C4HC2 type Vps39_2 PF10367.9 EMC82635.1 - 0.023 15.1 1.2 3.8 8.0 0.5 2.3 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 zf-RING-like PF08746.11 EMC82635.1 - 0.03 14.6 4.7 0.03 14.6 4.7 1.6 2 0 0 2 2 1 0 RING-like domain DUF3678 PF12435.8 EMC82635.1 - 0.046 13.1 0.7 0.046 13.1 0.7 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) zf-RING_4 PF14570.6 EMC82635.1 - 0.061 13.1 5.9 3.5 7.5 0.4 2.9 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain Rad50_zn_hook PF04423.14 EMC82635.1 - 0.071 13.0 4.9 0.49 10.3 0.0 3.1 3 0 0 3 3 3 0 Rad50 zinc hook motif DUF983 PF06170.12 EMC82635.1 - 0.09 13.2 0.1 4.4 7.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF983) Opy2 PF09463.10 EMC82635.1 - 0.36 11.2 4.3 31 5.0 0.1 3.3 3 0 0 3 3 3 0 Opy2 protein RINGv PF12906.7 EMC82635.1 - 0.43 10.8 4.1 0.91 9.7 4.1 1.6 1 1 0 1 1 1 0 RING-variant domain PHD PF00628.29 EMC82635.1 - 1.9 8.5 9.8 2.5 8.1 5.4 2.5 2 1 0 2 2 2 0 PHD-finger zf-H2C2_2 PF13465.6 EMC82635.1 - 2.1 8.9 4.3 35 5.1 0.1 2.8 3 0 0 3 3 2 0 Zinc-finger double domain FANCL_C PF11793.8 EMC82635.1 - 3 8.1 8.4 60 3.9 8.4 2.8 1 1 0 1 1 1 0 FANCL C-terminal domain IMUP PF15761.5 EMC82635.1 - 3.4 8.4 13.3 5.2 7.8 7.0 2.3 2 0 0 2 2 2 0 Immortalisation up-regulated protein zf-C3HC4_4 PF15227.6 EMC82635.1 - 4.9 7.4 10.4 5 7.4 6.8 2.7 2 1 1 3 3 3 0 zinc finger of C3HC4-type, RING Kazal_2 PF07648.15 EMC82636.1 - 1.5e-19 69.8 20.7 9e-11 41.7 6.0 3.9 4 0 0 4 4 4 2 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EMC82636.1 - 2.1e-07 30.8 18.5 5.7e-06 26.2 1.5 4.2 3 2 1 4 4 4 2 Kazal-type serine protease inhibitor domain FOLN PF09289.10 EMC82636.1 - 0.001 19.2 17.6 0.0059 16.8 10.2 3.3 2 0 0 2 2 2 2 Follistatin/Osteonectin-like EGF domain Trypsin PF00089.26 EMC82637.1 - 6.2e-48 163.5 0.0 6.9e-48 163.4 0.0 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 EMC82637.1 - 6e-05 23.4 0.0 7.7e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 EMC82637.1 - 0.0003 21.7 0.0 0.0004 21.3 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain AKAP2_C PF15304.6 EMC82638.1 - 5.8e-10 39.0 4.1 5.8e-10 39.0 4.1 4.4 3 2 0 3 3 3 1 A-kinase anchor protein 2 C-terminus RRM_5 PF13893.6 EMC82640.1 - 2.2e-58 195.3 0.2 2.2e-41 140.3 0.0 4.1 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 EMC82640.1 - 6.3e-37 125.2 1.2 9.5e-11 41.4 0.0 4.8 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 EMC82640.1 - 8.2e-16 58.0 0.0 4.6e-14 52.4 0.0 2.4 2 0 0 2 2 2 1 RRM-like domain RRM_occluded PF16842.5 EMC82640.1 - 1.4e-11 44.1 0.4 0.007 16.2 0.0 4.5 4 0 0 4 4 4 4 Occluded RNA-recognition motif Med16 PF11635.8 EMC82641.1 - 7e-137 457.4 0.1 9e-137 457.1 0.1 1.1 1 0 0 1 1 1 1 Mediator complex subunit 16 WD40 PF00400.32 EMC82641.1 - 0.00013 22.7 5.4 0.00026 21.7 1.9 3.3 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC82641.1 - 0.00026 21.2 0.2 0.053 13.8 0.2 3.4 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain ARID PF01388.21 EMC82642.1 - 5.8e-21 75.0 0.0 9e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain WD40 PF00400.32 EMC82643.1 - 1.1e-23 83.1 4.8 1e-09 38.8 0.2 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC82643.1 - 9.4e-06 25.8 0.0 0.0015 18.8 0.0 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMC82643.1 - 0.0033 16.1 0.5 0.039 12.6 0.1 2.1 1 1 1 2 2 2 1 Nucleoporin Nup120/160 Lig_chan-Glu_bd PF10613.9 EMC82644.1 - 1.9e-27 95.8 0.0 2.9e-26 91.9 0.0 2.3 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site Lig_chan PF00060.26 EMC82644.1 - 1.3e-23 83.5 0.0 3.2e-23 82.2 0.0 1.7 1 1 0 1 1 1 1 Ligand-gated ion channel SBP_bac_3 PF00497.20 EMC82644.1 - 4.9e-22 78.5 0.0 7.8e-22 77.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 ANF_receptor PF01094.28 EMC82644.1 - 0.11 11.6 0.0 0.27 10.3 0.0 1.6 2 0 0 2 2 2 0 Receptor family ligand binding region Calponin PF00402.18 EMC82645.1 - 4.2e-40 135.0 30.0 2.8e-16 58.8 1.6 4.9 5 0 0 5 5 5 3 Calponin family repeat CH PF00307.31 EMC82645.1 - 5.3e-23 81.3 0.1 8.5e-23 80.6 0.1 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EMC82645.1 - 0.0014 18.5 0.0 0.0026 17.5 0.0 1.4 1 0 0 1 1 1 1 CAMSAP CH domain RNA_pol_Rpb5_C PF01191.19 EMC82646.1 - 3.8e-35 119.6 0.2 5.9e-35 119.0 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 EMC82646.1 - 5.9e-13 49.2 0.0 1.2e-12 48.3 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain GSHPx PF00255.19 EMC82647.1 - 3e-08 33.2 0.0 3.4e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 EMC82647.1 - 0.051 13.5 0.0 0.051 13.5 0.0 1.1 1 0 0 1 1 1 0 AhpC/TSA family AAA_34 PF13872.6 EMC82648.1 - 2.6e-135 450.1 0.0 4e-135 449.5 0.0 1.3 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Helicase_C_4 PF13871.6 EMC82648.1 - 1.3e-118 395.6 0.1 1.8e-118 395.1 0.1 1.2 1 0 0 1 1 1 1 C-terminal domain on Strawberry notch homologue ResIII PF04851.15 EMC82648.1 - 1.2e-07 31.9 0.0 2.8e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 EMC82648.1 - 0.015 14.1 0.0 0.026 13.2 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain Helicase_C PF00271.31 EMC82648.1 - 0.11 12.8 0.0 0.59 10.5 0.0 2.3 1 1 0 1 1 1 0 Helicase conserved C-terminal domain ATP-synt_DE_N PF02823.16 EMC82649.1 - 5.7e-17 61.4 0.2 8.8e-17 60.8 0.2 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain DUF4140 PF13600.6 EMC82649.1 - 0.088 13.3 2.6 0.2 12.1 2.6 1.7 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) RRM_1 PF00076.22 EMC82651.1 - 4.3e-26 90.5 0.1 6e-26 90.1 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMC82651.1 - 0.00012 22.1 0.1 0.00025 21.1 0.1 1.6 1 1 0 1 1 1 1 RNA recognition motif RRM_occluded PF16842.5 EMC82651.1 - 0.00035 20.4 0.0 0.00073 19.4 0.0 1.4 1 1 0 1 1 1 1 Occluded RNA-recognition motif RRM_3 PF08777.11 EMC82651.1 - 0.059 13.4 0.1 0.094 12.8 0.1 1.4 1 0 0 1 1 1 0 RNA binding motif RRM_5 PF13893.6 EMC82651.1 - 0.08 12.5 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GRP PF07172.11 EMC82651.1 - 0.11 13.1 9.8 0.17 12.6 9.8 1.3 1 0 0 1 1 1 0 Glycine rich protein family PHM7_cyt PF14703.6 EMC82651.1 - 0.21 11.8 0.0 0.28 11.4 0.0 1.2 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter DNA_ligase_IV PF11411.8 EMC82651.1 - 0.7 10.1 3.1 4.4 7.5 0.0 2.5 2 0 0 2 2 2 0 DNA ligase IV Cornifin PF02389.15 EMC82653.1 - 3.5e-21 75.8 5.4 2.8e-07 30.8 4.1 4.2 1 1 3 4 4 4 4 Cornifin (SPRR) family Pkinase PF00069.25 EMC82654.1 - 3.3e-67 226.6 0.0 3.9e-67 226.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC82654.1 - 1.7e-25 89.8 0.0 2.1e-25 89.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC82654.1 - 7.5e-05 22.2 0.0 0.0001 21.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC82654.1 - 0.016 14.5 0.0 0.025 13.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 EMC82654.1 - 0.066 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pkinase_fungal PF17667.1 EMC82654.1 - 0.12 11.1 0.0 0.16 10.7 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase RIO1 PF01163.22 EMC82654.1 - 0.13 11.9 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 RIO1 family PWWP PF00855.17 EMC82655.1 - 5.5e-11 42.7 0.1 8.6e-05 22.9 0.0 3.0 2 0 0 2 2 2 2 PWWP domain Oxidored_q6 PF01058.22 EMC82656.1 - 1.9e-06 27.7 0.1 2.9e-06 27.1 0.1 1.3 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit DUF3079 PF11278.8 EMC82656.1 - 0.72 9.7 4.6 11 5.9 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3079) RRM_1 PF00076.22 EMC82657.1 - 7.4e-35 118.6 0.2 2.5e-16 59.2 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMC82657.1 - 2.4e-09 37.2 0.2 0.0016 18.5 0.1 2.5 2 1 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EMC82657.1 - 3.4e-05 23.7 0.1 0.16 12.0 0.1 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 EMC82657.1 - 0.00053 20.3 0.3 0.97 9.6 0.0 3.0 2 2 1 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter CSD PF00313.22 EMC82657.1 - 0.03 14.1 1.1 1.4 8.8 0.1 2.3 2 0 0 2 2 2 0 'Cold-shock' DNA-binding domain DUF4651 PF15513.6 EMC82657.1 - 0.16 11.8 0.2 7.2 6.5 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4651) Ribosomal_S19 PF00203.21 EMC82658.1 - 3.8e-33 113.2 0.3 5.3e-33 112.7 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Prok_Ub PF14454.6 EMC82658.1 - 0.018 14.7 0.2 0.046 13.4 0.1 1.7 2 0 0 2 2 2 0 Prokaryotic Ubiquitin LCAT PF02450.15 EMC82658.1 - 0.15 11.2 0.1 0.19 10.9 0.1 1.1 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase TIR_2 PF13676.6 EMC82659.1 - 6.5e-15 55.8 0.0 8e-15 55.5 0.0 1.1 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 EMC82659.1 - 3.2e-07 30.3 0.0 4.3e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 TIR domain TB2_DP1_HVA22 PF03134.19 EMC82660.1 - 1e-29 102.3 3.9 1.4e-29 101.8 3.9 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family RPM2 PF08579.11 EMC82660.1 - 0.14 12.6 0.0 0.21 12.0 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribonuclease P subunit (RPM2) Pkinase PF00069.25 EMC82661.1 - 3.8e-52 177.3 0.0 4.8e-52 176.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC82661.1 - 3.5e-27 95.3 0.0 4.9e-27 94.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EMC82661.1 - 0.00091 19.2 0.5 0.47 10.3 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EMC82661.1 - 0.0054 16.1 0.0 0.0089 15.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMC82661.1 - 0.0058 15.5 0.0 0.0086 14.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EMC82661.1 - 0.06 12.7 0.0 0.088 12.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EMC82661.1 - 0.22 11.1 0.0 0.32 10.6 0.0 1.1 1 0 0 1 1 1 0 RIO1 family Haspin_kinase PF12330.8 EMC82661.1 - 0.29 10.0 0.1 0.38 9.6 0.1 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Peptidase_M3 PF01432.20 EMC82662.1 - 1.6e-164 548.5 0.0 2.2e-164 548.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 CdvA PF18822.1 EMC82662.1 - 1.5 8.7 7.4 0.14 12.0 1.0 2.4 3 0 0 3 3 3 0 CdvA-like coiled-coil domain TPR_1 PF00515.28 EMC82663.1 - 9.7e-28 94.8 7.2 3.4e-10 39.3 0.0 3.7 4 0 0 4 4 3 3 Tetratricopeptide repeat SGTA_dimer PF16546.5 EMC82663.1 - 8.4e-22 76.7 0.9 3.2e-21 74.9 0.1 2.1 2 0 0 2 2 2 1 Homodimerisation domain of SGTA TPR_2 PF07719.17 EMC82663.1 - 1.6e-20 71.5 3.6 4.9e-06 26.3 0.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EMC82663.1 - 2.6e-20 70.9 2.1 2e-07 30.7 0.1 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 EMC82663.1 - 4.5e-17 61.4 6.3 5.1e-07 29.3 0.3 4.1 2 1 2 4 4 4 3 TPR repeat TPR_17 PF13431.6 EMC82663.1 - 1.7e-14 53.0 3.5 1.7e-06 28.0 0.2 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 EMC82663.1 - 5.1e-12 44.9 0.3 0.0011 18.8 0.0 3.9 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMC82663.1 - 2.2e-10 40.5 0.1 0.017 15.9 0.0 4.5 4 1 2 6 6 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMC82663.1 - 1.1e-09 38.7 1.3 1.8e-05 25.3 0.1 2.7 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EMC82663.1 - 5e-09 36.3 1.4 4.8e-07 30.0 0.3 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 EMC82663.1 - 5.3e-09 35.7 2.7 0.0089 15.9 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMC82663.1 - 1.8e-08 34.8 2.6 2.2e-05 24.8 0.0 3.4 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EMC82663.1 - 3.5e-05 23.9 0.0 0.0013 18.8 0.0 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TOM20_plant PF06552.12 EMC82663.1 - 9.9e-05 22.2 1.3 0.27 10.9 0.1 3.0 3 1 0 3 3 3 2 Plant specific mitochondrial import receptor subunit TOM20 Fis1_TPR_C PF14853.6 EMC82663.1 - 0.00015 21.8 5.4 0.05 13.7 0.1 3.4 3 1 1 4 4 4 2 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 EMC82663.1 - 0.0002 21.8 0.8 1.2 10.0 0.0 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat NARP1 PF12569.8 EMC82663.1 - 0.0027 16.7 0.3 1.4 7.7 0.4 2.2 1 1 1 2 2 2 2 NMDA receptor-regulated protein 1 DUF627 PF04781.12 EMC82663.1 - 0.0037 17.2 0.2 0.14 12.2 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF627) BTAD PF03704.17 EMC82663.1 - 0.006 17.0 1.2 0.42 11.0 0.0 2.6 2 1 1 3 3 3 1 Bacterial transcriptional activator domain TPR_15 PF13429.6 EMC82663.1 - 0.0064 15.7 0.0 1.6 7.9 0.0 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat XPC-binding PF09280.11 EMC82663.1 - 0.11 12.3 9.3 0.8 9.5 3.4 2.7 2 0 0 2 2 2 0 XPC-binding domain MIT PF04212.18 EMC82663.1 - 0.11 12.6 8.5 10 6.3 0.2 4.3 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TrbI PF03743.14 EMC82663.1 - 0.43 10.4 3.4 0.64 9.8 3.3 1.4 1 1 0 1 1 1 0 Bacterial conjugation TrbI-like protein STI1 PF17830.1 EMC82663.1 - 0.56 10.2 5.3 0.35 10.8 0.6 2.6 2 0 0 2 2 2 0 STI1 domain Zip PF02535.22 EMC82664.1 - 1.4e-50 172.5 12.1 1.6e-49 168.9 12.1 1.9 1 1 0 1 1 1 1 ZIP Zinc transporter DUF1129 PF06570.11 EMC82664.1 - 3.2 7.2 5.1 0.46 9.9 0.6 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1129) Ras PF00071.22 EMC82665.1 - 5.9e-50 169.0 0.2 7.5e-50 168.7 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC82665.1 - 5.1e-18 65.4 0.0 9.2e-18 64.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC82665.1 - 1.6e-07 30.9 0.0 2.3e-07 30.4 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EMC82665.1 - 1.3e-05 25.1 1.8 0.036 14.0 0.1 2.2 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EMC82665.1 - 0.00029 20.9 0.0 0.0005 20.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EMC82665.1 - 0.00076 19.0 0.3 0.0015 18.0 0.3 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EMC82665.1 - 0.0015 18.1 0.1 0.0041 16.7 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 EMC82665.1 - 0.0047 16.9 0.1 0.025 14.6 0.0 1.9 1 1 1 2 2 2 1 C-terminal region of MMR_HSR1 domain AAA_24 PF13479.6 EMC82665.1 - 0.019 14.7 0.4 0.17 11.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 EMC82665.1 - 0.027 13.4 0.2 2 7.4 0.1 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF2408 PF10303.9 EMC82665.1 - 0.03 14.9 1.8 0.68 10.5 1.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) FeoB_N PF02421.18 EMC82665.1 - 0.046 13.3 0.3 0.2 11.2 0.3 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_16 PF13191.6 EMC82665.1 - 0.057 13.8 0.2 0.074 13.4 0.2 1.5 1 1 0 1 1 1 0 AAA ATPase domain ATPase_2 PF01637.18 EMC82665.1 - 0.074 13.0 0.7 0.51 10.2 0.7 2.1 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EMC82665.1 - 0.084 13.2 0.6 0.7 10.2 0.6 2.5 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EMC82665.1 - 0.1 12.8 0.1 0.31 11.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain G-gamma PF00631.22 EMC82667.1 - 7.6e-19 67.5 0.0 8.4e-19 67.3 0.0 1.0 1 0 0 1 1 1 1 GGL domain FtsX_ECD PF18075.1 EMC82667.1 - 0.005 17.4 0.0 0.0056 17.3 0.0 1.0 1 0 0 1 1 1 1 FtsX extracellular domain CP12 PF02672.15 EMC82667.1 - 0.02 15.6 0.1 0.028 15.2 0.1 1.2 1 0 0 1 1 1 0 CP12 domain Ribosomal_L7Ae PF01248.26 EMC82668.1 - 2.4e-16 59.2 0.0 1.1e-15 57.1 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family SSF PF00474.17 EMC82670.1 - 1e-31 110.3 13.3 1.1e-31 110.1 13.3 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family Ccdc124 PF06244.12 EMC82671.1 - 2e-06 28.4 5.5 2e-06 28.4 5.5 2.5 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 UPF0240 PF06784.11 EMC82671.1 - 0.01 15.9 8.8 0.012 15.6 8.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0240) Asp-B-Hydro_N PF05279.11 EMC82671.1 - 4.2 7.4 25.6 5.2 7.1 25.6 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SK_channel PF03530.14 EMC82672.1 - 4.2e-40 136.3 3.1 8.4e-40 135.3 0.1 2.4 2 0 0 2 2 2 1 Calcium-activated SK potassium channel CaMBD PF02888.16 EMC82672.1 - 8.6e-24 83.5 5.6 1.6e-23 82.7 5.6 1.5 1 0 0 1 1 1 1 Calmodulin binding domain Ion_trans_2 PF07885.16 EMC82672.1 - 2.3e-13 49.9 2.9 2.3e-13 49.9 2.9 2.2 3 0 0 3 3 3 1 Ion channel IRK PF01007.20 EMC82672.1 - 0.093 12.5 2.6 0.3 10.9 2.6 1.9 1 0 0 1 1 1 0 Inward rectifier potassium channel transmembrane domain PMP1_2 PF08114.11 EMC82672.1 - 0.88 9.4 5.4 7.3 6.4 0.2 2.7 2 0 0 2 2 2 0 ATPase proteolipid family Occludin_ELL PF07303.13 EMC82673.1 - 1.3e-19 70.8 0.7 3.2e-08 34.2 0.0 2.1 1 1 1 2 2 2 2 Occludin homology domain RVT_1 PF00078.27 EMC82675.1 - 0.022 14.3 0.0 0.032 13.7 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) I-set PF07679.16 EMC82676.1 - 8.2e-16 57.9 0.0 1.8e-15 56.8 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC82676.1 - 2.7e-15 56.7 0.1 7.1e-15 55.4 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC82676.1 - 2.6e-11 43.5 0.1 6.1e-11 42.4 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC82676.1 - 6.6e-10 39.2 0.1 1.3e-09 38.3 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC82676.1 - 5.5e-06 26.5 1.0 0.00039 20.6 0.2 2.9 2 1 0 2 2 2 1 Immunoglobulin V-set domain DUF5362 PF17319.2 EMC82676.1 - 0.015 15.2 0.4 0.029 14.2 0.4 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5362) Ig_C17orf99 PF17736.1 EMC82676.1 - 0.086 12.9 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 C17orf99 Ig domain DUF4446 PF14584.6 EMC82676.1 - 0.14 12.1 0.8 0.28 11.2 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) DUF2228 PF10228.9 EMC82677.1 - 2.3e-112 374.8 0.1 2.8e-112 374.5 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2228) Nrf1_DNA-bind PF10491.9 EMC82677.1 - 0.031 14.0 0.3 0.14 11.9 0.0 2.0 2 0 0 2 2 2 0 NLS-binding and DNA-binding and dimerisation domains of Nrf1 Voltage_CLC PF00654.20 EMC82678.1 - 2.1e-105 352.9 20.5 3.1e-105 352.3 20.5 1.2 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.28 EMC82678.1 - 3.7e-11 43.3 0.7 0.00025 21.4 0.1 2.5 2 0 0 2 2 2 2 CBS domain SH3_9 PF14604.6 EMC82679.1 - 1.6e-53 178.4 1.2 5.2e-15 55.0 0.0 4.4 4 0 0 4 4 4 4 Variant SH3 domain SH3_1 PF00018.28 EMC82679.1 - 5e-50 166.9 1.8 4.6e-12 45.3 0.0 4.3 4 0 0 4 4 4 4 SH3 domain SH3_2 PF07653.17 EMC82679.1 - 1.3e-35 120.9 1.7 6.8e-09 35.3 0.1 4.3 4 0 0 4 4 4 4 Variant SH3 domain zf-C3HC4 PF00097.25 EMC82679.1 - 4.1e-09 36.1 7.0 8.1e-09 35.2 7.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC82679.1 - 5.8e-09 35.8 5.5 1.4e-08 34.6 5.5 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EMC82679.1 - 7.4e-09 35.3 7.4 1.6e-08 34.2 7.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC82679.1 - 1.9e-08 34.5 7.6 4e-08 33.4 7.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EMC82679.1 - 1.3e-06 28.2 6.6 2.4e-06 27.4 6.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EMC82679.1 - 1.9e-06 27.6 8.8 3.4e-06 26.8 8.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMC82679.1 - 0.00011 22.2 7.6 0.00021 21.4 7.6 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EMC82679.1 - 0.00045 20.0 5.0 0.00045 20.0 5.0 1.7 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 EMC82679.1 - 0.00088 19.1 8.4 0.0063 16.4 8.8 2.1 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 EMC82679.1 - 0.0072 16.0 2.8 0.02 14.6 2.8 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-Nse PF11789.8 EMC82679.1 - 0.12 12.3 2.3 0.29 11.0 2.3 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-MIZ PF02891.20 EMC82679.1 - 0.12 12.1 5.2 0.25 11.1 5.2 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-rbx1 PF12678.7 EMC82679.1 - 0.33 11.3 3.7 0.88 9.9 3.7 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain Trm112p PF03966.16 EMC82679.1 - 1.7 9.3 5.9 5.4 7.7 5.9 1.9 1 0 0 1 1 1 0 Trm112p-like protein adh_short_C2 PF13561.6 EMC82680.1 - 1.2e-59 201.7 1.3 1.5e-59 201.4 1.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMC82680.1 - 1.5e-54 184.5 4.0 1.7e-54 184.3 4.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMC82680.1 - 7.4e-18 65.1 1.8 1.1e-16 61.3 1.7 2.0 1 1 1 2 2 2 1 KR domain Epimerase PF01370.21 EMC82680.1 - 0.0022 17.5 0.2 0.0043 16.5 0.2 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 EMC82680.1 - 0.0041 17.2 0.6 0.79 9.8 0.1 2.4 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 EMC82680.1 - 0.008 16.1 0.8 0.011 15.6 0.8 1.4 1 1 0 1 1 1 1 NAD(P)H-binding I-set PF07679.16 EMC82681.1 - 3.2e-109 357.3 0.0 2.6e-22 78.7 0.0 6.4 6 0 0 6 6 6 6 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC82681.1 - 9.8e-72 237.6 0.0 5.1e-15 55.8 0.0 6.8 6 0 0 6 6 6 5 Immunoglobulin domain Ig_2 PF13895.6 EMC82681.1 - 1.1e-52 176.3 0.3 1.1e-10 41.7 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 EMC82681.1 - 2.6e-48 162.1 2.1 6.8e-10 39.0 0.1 6.1 5 1 0 5 5 5 5 Immunoglobulin domain V-set PF07686.17 EMC82681.1 - 4.6e-20 71.8 7.2 0.046 13.9 0.0 8.6 5 4 0 5 5 5 5 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC82681.1 - 2.1e-15 56.6 1.9 0.027 14.5 0.0 6.2 5 1 0 5 5 5 5 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 EMC82681.1 - 2.8e-06 27.6 0.2 0.47 10.9 0.1 4.9 5 0 0 5 5 5 2 Immunoglobulin C1-set domain Receptor_2B4 PF11465.8 EMC82681.1 - 9.8e-05 22.5 0.0 0.31 11.3 0.0 4.2 5 0 0 5 5 5 1 Natural killer cell receptor 2B4 Ig_6 PF18452.1 EMC82681.1 - 0.00022 20.7 0.2 0.11 12.1 0.0 3.9 4 0 0 4 4 4 1 Immunoglobulin domain Ig_C17orf99 PF17736.1 EMC82681.1 - 0.00041 20.3 0.1 33 4.6 0.0 5.1 5 1 0 5 5 5 0 C17orf99 Ig domain C2-set PF05790.15 EMC82681.1 - 0.021 15.0 0.5 11 6.3 0.1 4.3 4 0 0 4 4 4 0 Immunoglobulin C2-set domain DEAD PF00270.29 EMC82682.1 - 5.8e-18 65.3 0.0 2.1e-17 63.5 0.0 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EMC82682.1 - 2.4e-13 50.5 3.7 3.2e-11 43.5 0.0 3.7 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EMC82682.1 - 1.4e-05 25.4 0.0 0.00012 22.4 0.0 2.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Peptidase_S64 PF08192.11 EMC82682.1 - 0.0082 14.7 6.1 0.015 13.8 6.1 1.3 1 0 0 1 1 1 1 Peptidase family S64 DUF1890 PF09001.11 EMC82682.1 - 0.046 14.1 0.1 0.53 10.7 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1890) Ribosomal_L18p PF00861.22 EMC82682.1 - 0.093 13.1 1.3 0.35 11.2 1.3 2.0 1 0 0 1 1 1 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast WSD PF15613.6 EMC82682.1 - 0.16 12.4 3.5 15 6.1 0.1 2.9 2 0 0 2 2 2 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif CAP_N PF01213.19 EMC82683.1 - 0.021 14.3 1.1 0.034 13.6 0.6 1.5 1 1 1 2 2 2 0 Adenylate cyclase associated (CAP) N terminal PIN_2 PF10130.9 EMC82683.1 - 0.041 14.1 0.2 0.076 13.3 0.2 1.5 1 1 0 1 1 1 0 PIN domain DXP_synthase_N PF13292.6 EMC82683.1 - 0.056 12.6 0.4 0.084 12.1 0.4 1.2 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase DUF2408 PF10303.9 EMC82683.1 - 0.41 11.2 7.0 0.97 10.0 6.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) zf-B_box PF00643.24 EMC82683.1 - 1.7 8.9 5.5 0.25 11.6 0.8 2.0 2 0 0 2 2 2 0 B-box zinc finger Annexin PF00191.20 EMC82684.1 - 1.9e-65 216.9 9.0 3.5e-21 75.1 0.2 4.0 4 0 0 4 4 4 4 Annexin BTB PF00651.31 EMC82685.1 - 6.2e-27 94.0 0.3 8.8e-27 93.5 0.3 1.2 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 EMC82685.1 - 9.7e-09 35.3 2.4 9.7e-09 35.3 2.4 3.2 3 0 0 3 3 3 1 Zinc-finger double domain DUF3342 PF11822.8 EMC82685.1 - 5.7e-06 26.4 0.1 1.2e-05 25.5 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) zf-C2H2 PF00096.26 EMC82685.1 - 0.00026 21.3 17.9 0.00094 19.5 0.9 3.3 4 0 0 4 4 4 2 Zinc finger, C2H2 type BTB_2 PF02214.22 EMC82685.1 - 0.00073 19.8 0.0 0.0013 19.0 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_5 PF13909.6 EMC82685.1 - 0.0011 18.7 4.9 0.0013 18.4 3.2 2.1 2 0 0 2 2 2 1 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 EMC82685.1 - 0.0014 19.3 15.0 0.0068 17.2 0.8 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-Di19 PF05605.12 EMC82685.1 - 0.1 12.9 3.7 0.23 11.8 3.7 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 EMC82685.1 - 0.13 12.6 0.1 0.13 12.6 0.1 3.3 4 0 0 4 4 4 0 Zinc-finger of C2H2 type Herpes_ori_bp PF02399.15 EMC82686.1 - 0.011 13.8 0.2 0.014 13.5 0.2 1.0 1 0 0 1 1 1 0 Origin of replication binding protein zf-H2C2_2 PF13465.6 EMC82686.1 - 0.067 13.6 0.7 0.067 13.6 0.7 1.8 2 0 0 2 2 2 0 Zinc-finger double domain Sulfotransfer_4 PF17784.1 EMC82686.1 - 0.19 11.5 0.0 0.2 11.5 0.0 1.1 1 0 0 1 1 1 0 Sulfotransferase domain Pkinase PF00069.25 EMC82687.1 - 7.5e-66 222.2 0.0 8.5e-66 222.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC82687.1 - 4.2e-35 121.3 0.0 5e-35 121.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC82687.1 - 6.7e-05 22.4 0.0 0.00012 21.5 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC82687.1 - 0.0034 16.8 0.0 0.0048 16.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EMC82687.1 - 0.0098 15.5 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Arm PF00514.23 EMC82688.1 - 2.9e-90 293.9 21.9 1.2e-13 50.5 0.0 9.0 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 EMC82688.1 - 4.1e-25 88.0 1.9 4.1e-25 88.0 1.9 1.8 2 0 0 2 2 1 1 Importin beta binding domain Arm_3 PF16186.5 EMC82688.1 - 1e-22 79.4 2.9 2e-22 78.5 1.8 2.2 3 0 0 3 3 3 1 Atypical Arm repeat HEAT_2 PF13646.6 EMC82688.1 - 3.7e-21 75.3 0.0 2.4e-07 31.0 0.0 5.0 3 2 2 5 5 4 4 HEAT repeats HEAT_EZ PF13513.6 EMC82688.1 - 7.8e-21 74.2 6.1 7.1e-07 29.6 0.0 6.1 5 2 2 7 7 7 3 HEAT-like repeat HEAT PF02985.22 EMC82688.1 - 8.2e-14 50.5 8.3 0.0031 17.6 0.0 7.8 9 0 0 9 9 9 2 HEAT repeat V-ATPase_H_C PF11698.8 EMC82688.1 - 3.4e-06 27.2 0.0 0.24 11.5 0.0 4.3 3 2 1 4 4 4 2 V-ATPase subunit H RICTOR_V PF14668.6 EMC82688.1 - 4.5e-06 26.8 1.4 0.71 10.2 0.0 4.8 4 1 1 5 5 4 1 Rapamycin-insensitive companion of mTOR, domain 5 Arm_2 PF04826.13 EMC82688.1 - 1.5e-05 24.6 0.1 0.1 12.1 0.0 2.8 1 1 1 2 2 2 2 Armadillo-like HEAT_PBS PF03130.16 EMC82688.1 - 0.00051 20.5 0.2 8.7 7.3 0.0 4.9 5 0 0 5 5 4 1 PBS lyase HEAT-like repeat CTNNBL PF08216.11 EMC82688.1 - 0.013 15.6 0.0 3.2 8.0 0.0 3.9 4 0 0 4 4 4 0 Catenin-beta-like, Arm-motif containing nuclear SEN1_N PF12726.7 EMC82688.1 - 0.044 12.0 0.0 4.2 5.4 0.0 2.8 2 1 1 3 3 3 0 SEN1 N terminal NUSAP PF16006.5 EMC82688.1 - 3 7.5 6.8 4.2 7.0 6.8 1.2 1 0 0 1 1 1 0 Nucleolar and spindle-associated protein Taxilin PF09728.9 EMC82689.1 - 6.2e-106 354.1 74.3 7.3e-106 353.8 74.3 1.0 1 0 0 1 1 1 1 Myosin-like coiled-coil protein FlaC_arch PF05377.11 EMC82689.1 - 0.011 16.1 19.6 0.25 11.8 1.1 4.3 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) KELK PF15796.5 EMC82689.1 - 0.1 13.1 0.5 0.1 13.1 0.5 6.6 3 1 3 6 6 6 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase NDUFB11 PF17250.2 EMC82689.1 - 0.4 11.4 3.1 0.55 10.9 1.0 2.4 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase 11 kDa subunit Phage_GPL PF05926.11 EMC82689.1 - 2.2 8.3 11.1 0.16 12.0 2.4 2.7 2 1 0 2 2 2 0 Phage head completion protein (GPL) SpoVAD PF07451.11 EMC82689.1 - 4.8 5.8 7.2 10 4.7 0.7 2.2 2 0 0 2 2 2 0 Stage V sporulation protein AD (SpoVAD) Shugoshin_N PF07558.11 EMC82689.1 - 7.3 6.5 16.7 5.6 6.9 1.2 4.7 4 1 1 5 5 5 0 Shugoshin N-terminal coiled-coil region WD40 PF00400.32 EMC82690.1 - 1.4e-21 76.4 3.1 1.1e-06 29.2 2.0 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC82690.1 - 1.5e-10 41.2 0.0 0.0031 17.8 0.0 4.1 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMC82690.1 - 0.00049 19.2 0.2 0.52 9.2 0.0 3.0 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein ISN1 PF06437.11 EMC82690.1 - 0.0034 16.3 0.0 0.59 9.0 0.0 2.0 2 0 0 2 2 2 2 IMP-specific 5'-nucleotidase Nup160 PF11715.8 EMC82690.1 - 0.024 13.3 0.3 1.7 7.2 0.1 2.0 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Pkinase_Tyr PF07714.17 EMC82691.1 - 4.2e-62 209.8 0.0 4.8e-62 209.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC82691.1 - 4.4e-27 95.1 0.0 4.9e-27 94.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 EMC82691.1 - 0.0015 17.5 0.5 0.0019 17.2 0.1 1.4 2 0 0 2 2 2 1 Haspin like kinase domain RelB_N PF18506.1 EMC82691.1 - 0.14 12.0 0.2 4.4 7.2 0.0 2.6 3 0 0 3 3 3 0 RelB Antitoxin alpha helical domain Hist_deacetyl PF00850.19 EMC82692.1 - 2.2e-85 286.8 1.0 2.7e-85 286.6 0.1 1.5 2 0 0 2 2 2 1 Histone deacetylase domain RNA_polI_A34 PF08208.11 EMC82692.1 - 2.9 8.0 20.6 4.5 7.3 20.6 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 MARCKS PF02063.17 EMC82693.1 - 1e-14 55.2 30.7 1.3e-14 54.9 30.7 1.2 1 0 0 1 1 1 1 MARCKS family Tmp39 PF10271.9 EMC82694.1 - 6.8e-207 687.7 19.7 8.3e-207 687.4 19.7 1.0 1 0 0 1 1 1 1 Putative transmembrane protein KH_1 PF00013.29 EMC82696.1 - 9.7e-12 44.6 0.0 1.7e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 KH domain Qua1 PF16274.5 EMC82696.1 - 1.7e-09 37.4 3.6 1.7e-09 37.4 3.6 2.2 3 0 0 3 3 3 1 Qua1 domain KH_5 PF13184.6 EMC82696.1 - 0.073 13.2 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 NusA-like KH domain KH_2 PF07650.17 EMC82696.1 - 0.13 12.2 0.1 0.24 11.3 0.1 1.5 1 0 0 1 1 1 0 KH domain DSPc PF00782.20 EMC82697.1 - 9.1e-08 32.0 0.0 1.3e-07 31.5 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC82697.1 - 1.1e-07 31.7 0.0 2.9e-07 30.3 0.0 1.6 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EMC82697.1 - 0.15 12.0 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family HrpB1_HrpK PF09613.10 EMC82698.1 - 1 9.0 4.9 30 4.2 0.2 3.0 1 1 3 4 4 4 0 Bacterial type III secretion protein (HrpB1_HrpK) Collagen PF01391.18 EMC82699.1 - 3.4e-22 78.0 107.9 1.9e-09 37.1 31.2 4.2 3 1 1 4 4 4 4 Collagen triple helix repeat (20 copies) EF-hand_1 PF00036.32 EMC82700.1 - 3.1e-18 63.9 0.1 1.9e-06 27.0 0.0 4.1 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EMC82700.1 - 2.8e-17 61.1 0.1 2.7e-06 26.8 0.0 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 EMC82700.1 - 1e-16 59.6 0.3 6.9e-06 25.3 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EMC82700.1 - 1.8e-16 60.3 0.3 4.4e-08 33.5 0.0 2.7 2 1 0 2 2 2 2 EF-hand domain pair Collagen PF01391.18 EMC82700.1 - 2.8e-12 46.2 62.0 1.1e-08 34.6 26.1 2.3 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) EF-hand_8 PF13833.6 EMC82700.1 - 2.3e-09 37.0 0.1 0.00053 19.8 0.0 4.0 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.6 EMC82700.1 - 0.0083 16.4 0.0 6.4 7.2 0.0 3.0 2 1 0 2 2 2 2 EF-hand domain EF-hand_2 PF09068.11 EMC82700.1 - 0.023 14.8 0.3 2.6 8.2 0.0 2.8 1 1 1 2 2 2 0 EF hand Caleosin PF05042.13 EMC82700.1 - 0.077 12.9 0.1 0.4 10.6 0.0 1.9 1 1 1 2 2 2 0 Caleosin related protein KCNQ_channel PF03520.14 EMC82701.1 - 6.7e-90 300.0 0.1 8.4e-90 299.7 0.1 1.1 1 0 0 1 1 1 1 KCNQ voltage-gated potassium channel CBFD_NFYB_HMF PF00808.23 EMC82702.1 - 1.4e-21 76.6 2.0 6.2e-21 74.5 1.3 2.3 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EMC82702.1 - 3.2e-15 56.7 0.9 3.2e-15 56.7 0.9 1.9 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.10 EMC82702.1 - 0.12 12.8 0.1 0.28 11.5 0.1 1.7 1 0 0 1 1 1 0 CENP-S associating Centromere protein X Phage_TAC_7 PF10109.9 EMC82702.1 - 1.7 8.8 4.3 1.1 9.5 0.2 2.7 3 1 0 3 3 3 0 Phage tail assembly chaperone proteins, E, or 41 or 14 C2 PF00168.30 EMC82703.1 - 6.2e-16 58.6 0.0 1.1e-15 57.8 0.0 1.4 1 0 0 1 1 1 1 C2 domain ArfGap PF01412.18 EMC82704.1 - 1.6e-32 112.0 0.1 3.5e-32 110.9 0.1 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Collagen PF01391.18 EMC82705.1 - 3.7e-67 222.0 274.3 1.6e-09 37.3 27.7 10.2 3 3 7 10 10 10 10 Collagen triple helix repeat (20 copies) DUF4688 PF15752.5 EMC82706.1 - 2.9e-06 26.8 0.1 8.5e-06 25.2 0.1 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4688) DUF4688 PF15752.5 EMC82707.1 - 3e-36 125.5 26.2 3.5e-36 125.3 26.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4688) Connexin PF00029.19 EMC82708.1 - 2.4e-80 269.7 9.8 3.1e-78 262.8 9.8 2.0 1 1 0 1 1 1 1 Connexin Connexin PF00029.19 EMC82709.1 - 7.3e-82 274.6 9.8 3.4e-80 269.2 9.8 2.0 1 1 0 1 1 1 1 Connexin 7tm_1 PF00001.21 EMC82709.1 - 0.0013 18.2 4.2 0.1 11.9 1.3 2.1 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) DUF3404 PF11884.8 EMC82709.1 - 0.011 15.0 0.0 0.018 14.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3404) UbiA PF01040.18 EMC82709.1 - 0.028 13.7 0.1 0.06 12.6 0.0 1.5 2 0 0 2 2 2 0 UbiA prenyltransferase family Ninjurin PF04923.12 EMC82709.1 - 0.13 12.2 1.7 0.99 9.4 0.0 2.8 3 1 0 3 3 3 0 Ninjurin Connexin PF00029.19 EMC82710.1 - 7e-101 336.9 2.3 8.5e-101 336.6 2.3 1.1 1 0 0 1 1 1 1 Connexin Connexin43 PF03508.13 EMC82710.1 - 0.0007 19.1 3.6 0.0015 18.0 3.6 1.5 1 0 0 1 1 1 1 Gap junction alpha-1 protein (Cx43) KELK PF15796.5 EMC82710.1 - 0.074 13.5 1.2 0.13 12.7 1.2 1.3 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DoxX_2 PF13564.6 EMC82712.1 - 2.3e-08 34.1 3.5 2.8e-08 33.8 3.5 1.1 1 0 0 1 1 1 1 DoxX-like family DoxX PF07681.12 EMC82712.1 - 0.00094 19.7 1.6 0.00094 19.7 1.6 1.9 1 1 1 2 2 2 1 DoxX RRM_1 PF00076.22 EMC82713.1 - 1.4e-30 104.9 0.1 7.2e-15 54.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOPS PF08075.11 EMC82713.1 - 9.3e-20 70.6 0.8 3.1e-19 68.9 0.8 2.0 1 1 0 1 1 1 1 NOPS (NUC059) domain RRM_7 PF16367.5 EMC82713.1 - 0.0013 18.8 0.0 0.014 15.5 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif AAA_21 PF13304.6 EMC82713.1 - 0.14 12.0 0.5 0.21 11.3 0.5 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system DDHD PF02862.17 EMC82713.1 - 0.25 11.5 2.4 0.35 11.0 2.4 1.1 1 0 0 1 1 1 0 DDHD domain ALMT PF11744.8 EMC82713.1 - 5.4 5.7 11.0 7.2 5.3 11.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter RVT_1 PF00078.27 EMC82714.1 - 0.12 11.9 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Y_Y_Y PF07495.13 EMC82717.1 - 1.7e-13 50.3 1.4 0.0043 17.0 0.0 5.3 5 0 0 5 5 5 3 Y_Y_Y domain PKD PF00801.20 EMC82717.1 - 2e-13 50.0 8.9 0.0051 16.6 0.1 5.7 5 0 0 5 5 5 4 PKD domain Big_9 PF17963.1 EMC82717.1 - 1.2e-12 48.4 29.4 0.00033 21.3 1.7 5.4 5 0 0 5 5 5 4 Bacterial Ig domain DUF4625 PF15418.6 EMC82717.1 - 4e-11 43.3 0.2 0.19 11.9 0.0 4.4 4 0 0 4 4 4 4 Domain of unknown function (DUF4625) DUF4998 PF16389.5 EMC82717.1 - 1.5e-06 28.0 1.6 0.38 10.3 0.0 4.1 4 0 0 4 4 4 3 Domain of unknown function He_PIG PF05345.12 EMC82717.1 - 2e-05 24.7 10.7 0.26 11.5 0.0 5.7 6 0 0 6 6 5 2 Putative Ig domain DUF5013 PF16405.5 EMC82717.1 - 5.1e-05 23.6 1.1 0.066 13.5 0.1 4.0 4 1 0 4 4 4 1 Domain of unknown function (DUF5013) Wzt_C PF14524.6 EMC82717.1 - 0.00021 21.3 0.0 4.3 7.4 0.0 4.1 4 0 0 4 4 4 1 Wzt C-terminal domain AMPK1_CBM PF16561.5 EMC82717.1 - 0.00062 19.9 0.1 5.4 7.3 0.0 4.8 6 0 0 6 6 6 1 Glycogen recognition site of AMP-activated protein kinase fn3 PF00041.21 EMC82717.1 - 0.0029 17.9 0.6 0.45 10.9 0.0 3.9 3 1 0 3 3 3 1 Fibronectin type III domain Cadherin_5 PF17892.1 EMC82717.1 - 0.0034 17.3 5.4 1.6 8.7 0.1 4.5 4 0 0 4 4 4 1 Cadherin-like domain DUF5011 PF16403.5 EMC82717.1 - 0.022 14.8 9.8 23 5.2 0.1 4.9 5 0 0 5 5 5 0 Domain of unknown function (DUF5011) EGF_2 PF07974.13 EMC82717.1 - 0.023 15.0 4.8 0.045 14.1 4.8 1.4 1 0 0 1 1 1 0 EGF-like domain CopC PF04234.12 EMC82717.1 - 0.031 15.3 4.9 9.5 7.3 0.1 4.4 4 0 0 4 4 4 0 CopC domain TMEM154 PF15102.6 EMC82717.1 - 0.072 13.0 0.6 0.24 11.3 0.0 2.1 2 0 0 2 2 2 0 TMEM154 protein family TIG PF01833.24 EMC82717.1 - 0.16 12.1 2.9 3.8 7.7 0.2 4.1 3 1 0 3 3 3 0 IPT/TIG domain Shisa PF13908.6 EMC82717.1 - 0.18 12.0 0.1 0.18 12.0 0.1 2.1 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator TF_AP-2 PF03299.14 EMC82718.1 - 1.1e-85 286.7 0.0 1.3e-85 286.3 0.0 1.1 1 0 0 1 1 1 1 Transcription factor AP-2 Proteasome PF00227.26 EMC82719.1 - 2e-35 122.0 0.0 2.3e-35 121.8 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit DUF4653 PF15546.6 EMC82720.1 - 1.1e-39 136.6 5.7 1.1e-39 136.6 5.7 1.9 1 1 1 2 2 2 2 Domain of unknown function (DUF4653) Piwi PF02171.17 EMC82722.1 - 4.3e-105 351.3 0.0 6.7e-105 350.6 0.0 1.3 1 0 0 1 1 1 1 Piwi domain ArgoMid PF16487.5 EMC82722.1 - 4e-33 113.5 0.4 1.4e-32 111.8 0.1 2.2 2 0 0 2 2 2 1 Mid domain of argonaute ArgoN PF16486.5 EMC82722.1 - 3.2e-30 105.5 0.0 8.9e-30 104.1 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of argonaute PAZ PF02170.22 EMC82722.1 - 4.3e-28 97.8 1.9 7.3e-28 97.1 1.9 1.4 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.10 EMC82722.1 - 1.2e-22 79.3 0.1 2.8e-22 78.1 0.1 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 EMC82722.1 - 3.4e-15 56.1 0.0 7.7e-15 55.0 0.0 1.7 1 0 0 1 1 1 1 Argonaute linker 2 domain Piwi PF02171.17 EMC82723.1 - 3.8e-106 354.7 0.0 5.6e-106 354.2 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoMid PF16487.5 EMC82723.1 - 7.9e-35 119.0 0.1 2.8e-34 117.2 0.1 2.0 1 0 0 1 1 1 1 Mid domain of argonaute ArgoN PF16486.5 EMC82723.1 - 1.2e-28 100.5 0.0 3.1e-28 99.1 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of argonaute PAZ PF02170.22 EMC82723.1 - 1.3e-28 99.5 1.3 1.3e-28 99.5 1.3 1.6 2 0 0 2 2 2 1 PAZ domain ArgoL1 PF08699.10 EMC82723.1 - 3.5e-23 81.0 0.0 7.4e-23 80.0 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 EMC82723.1 - 4.6e-16 58.9 0.0 9.6e-16 57.9 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 2 domain Tautomerase_3 PF14832.6 EMC82723.1 - 0.028 14.6 0.1 10 6.3 0.0 3.0 3 0 0 3 3 3 0 Putative oxalocrotonate tautomerase enzyme Piwi PF02171.17 EMC82724.1 - 7.8e-114 380.0 0.0 1.1e-113 379.5 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoMid PF16487.5 EMC82724.1 - 1e-32 112.2 0.4 3.6e-32 110.5 0.1 2.1 2 0 0 2 2 2 1 Mid domain of argonaute PAZ PF02170.22 EMC82724.1 - 8.2e-29 100.2 0.8 1.3e-28 99.5 0.8 1.3 1 0 0 1 1 1 1 PAZ domain ArgoN PF16486.5 EMC82724.1 - 4.4e-26 92.1 0.0 1.3e-25 90.7 0.0 1.9 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 EMC82724.1 - 1.5e-22 79.0 0.0 3.3e-22 77.9 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 EMC82724.1 - 1e-12 48.2 0.2 2.9e-12 46.7 0.0 1.9 2 0 0 2 2 2 1 Argonaute linker 2 domain Tektin PF03148.14 EMC82725.1 - 2.3e-120 401.9 39.0 2.6e-120 401.7 39.0 1.0 1 0 0 1 1 1 1 Tektin family DUF1664 PF07889.12 EMC82725.1 - 0.0023 18.0 15.4 0.17 11.9 0.9 4.2 3 1 1 4 4 4 2 Protein of unknown function (DUF1664) DUF948 PF06103.11 EMC82725.1 - 0.31 11.3 9.3 2.5 8.4 0.3 4.2 4 1 1 5 5 5 0 Bacterial protein of unknown function (DUF948) DUF5082 PF16888.5 EMC82725.1 - 1.2 9.4 23.4 0.63 10.3 2.1 4.7 3 1 0 3 3 3 0 Domain of unknown function (DUF5082) ADP_ribosyl_GH PF03747.14 EMC82726.1 - 1.1e-44 153.3 0.0 1.3e-44 153.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Collagen PF01391.18 EMC82727.1 - 2.8e-55 183.9 252.7 9.2e-08 31.7 21.3 9.4 1 1 5 6 6 6 4 Collagen triple helix repeat (20 copies) C1q PF00386.21 EMC82727.1 - 1.7e-38 131.7 0.1 2.1e-38 131.4 0.1 1.1 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 EMC82727.1 - 0.0063 16.4 0.0 0.0093 15.9 0.0 1.1 1 0 0 1 1 1 1 BclA C-terminal domain TRAPP PF04051.16 EMC82728.1 - 3.2e-37 127.5 0.0 3.7e-37 127.3 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component THRAP3_BCLAF1 PF15440.6 EMC82729.1 - 5.8e-200 666.7 117.3 5.8e-200 666.7 117.3 2.4 2 0 0 2 2 2 1 THRAP3/BCLAF1 family FAM176 PF14851.6 EMC82730.1 - 3.7e-48 162.9 0.1 5.4e-48 162.3 0.1 1.2 1 0 0 1 1 1 1 FAM176 family NUP50 PF08911.11 EMC82730.1 - 0.14 12.8 1.7 0.17 12.6 0.8 1.7 2 0 0 2 2 2 0 NUP50 (Nucleoporin 50 kDa) Pkinase PF00069.25 EMC82731.1 - 2.1e-37 128.9 0.0 3.2e-37 128.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC82731.1 - 1.5e-20 73.6 0.0 2.5e-20 72.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC82731.1 - 2.9e-05 23.6 1.1 0.00055 19.3 0.1 2.5 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EMC82731.1 - 0.00069 18.5 0.0 0.0011 17.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EMC82731.1 - 0.0064 15.5 0.7 0.015 14.2 0.7 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EMC82731.1 - 0.033 13.6 0.1 0.061 12.7 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LSM PF01423.22 EMC82732.1 - 4.1e-12 45.6 0.2 5.9e-12 45.1 0.2 1.3 1 0 0 1 1 1 1 LSM domain Oscp1 PF10188.9 EMC82733.1 - 1.2e-78 263.2 2.5 1.5e-78 262.9 2.5 1.1 1 0 0 1 1 1 1 Organic solute transport protein 1 Ribosomal_S15 PF00312.22 EMC82734.1 - 1.6e-29 101.9 2.1 2.8e-29 101.1 2.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S15 ADIP PF11559.8 EMC82734.1 - 0.036 14.2 1.3 0.036 14.2 1.3 2.0 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding FliJ PF02050.16 EMC82734.1 - 2.5 8.3 15.4 6.9 6.9 1.9 2.4 2 1 0 2 2 2 0 Flagellar FliJ protein ATP_bind_3 PF01171.20 EMC82734.1 - 6.3 6.5 8.4 0.26 11.0 1.0 2.2 2 1 0 2 2 2 0 PP-loop family Lep_receptor_Ig PF06328.11 EMC82735.1 - 1.3e-14 53.8 0.1 8.4e-14 51.3 0.0 2.1 2 0 0 2 2 2 1 Ig-like C2-type domain EpoR_lig-bind PF09067.10 EMC82735.1 - 8.7e-06 25.9 0.0 3.3e-05 24.0 0.0 1.9 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding ObR_Ig PF18589.1 EMC82735.1 - 0.0053 17.1 0.6 0.013 15.8 0.6 1.7 1 1 0 1 1 1 1 Obesity receptor immunoglobulin like domain C2-set_2 PF08205.12 EMC82735.1 - 0.018 15.1 0.8 2.2 8.4 0.2 2.7 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain ANF_receptor PF01094.28 EMC82736.1 - 7.2e-72 242.4 0.0 9.5e-72 242.0 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan-Glu_bd PF10613.9 EMC82736.1 - 3.8e-46 156.0 0.0 1.6e-45 154.0 0.0 2.1 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site Lig_chan PF00060.26 EMC82736.1 - 1.5e-36 125.4 0.1 2.7e-36 124.6 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel SBP_bac_3 PF00497.20 EMC82736.1 - 2.6e-19 69.6 0.0 5.9e-19 68.4 0.0 1.6 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.6 EMC82736.1 - 7.1e-05 22.6 0.0 0.00013 21.7 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein Fibrinogen_BP PF08017.11 EMC82737.1 - 0.0071 14.8 0.0 0.0091 14.5 0.0 1.1 1 0 0 1 1 1 1 Fibrinogen binding protein Phage_hub_GP28 PF11110.8 EMC82737.1 - 0.78 9.6 3.5 1.6e+02 2.1 0.0 5.2 2 2 11 13 13 13 0 Baseplate hub distal subunit RNase_Zc3h12a PF11977.8 EMC82738.1 - 9.8e-66 220.3 0.0 1.1e-64 217.0 0.0 2.0 2 0 0 2 2 2 1 Zc3h12a-like Ribonuclease NYN domain UBA_6 PF18039.1 EMC82738.1 - 9e-20 70.3 0.4 1.4e-19 69.7 0.4 1.3 1 0 0 1 1 1 1 UBA-like domain zf-CCCH_4 PF18044.1 EMC82738.1 - 3.8e-05 23.4 3.5 6.9e-05 22.6 3.5 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 EMC82738.1 - 0.035 14.6 6.0 0.073 13.6 6.0 1.6 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Pex14_N PF04695.13 EMC82738.1 - 0.05 14.3 1.1 0.25 12.0 0.0 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region B5 PF03484.15 EMC82738.1 - 0.074 13.4 0.0 1.2 9.5 0.0 2.6 2 2 0 2 2 2 0 tRNA synthetase B5 domain zf-CCCH PF00642.24 EMC82738.1 - 0.17 11.8 8.7 0.048 13.6 2.8 2.6 2 1 1 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) FHA PF00498.26 EMC82740.1 - 1.7e-17 63.5 0.0 2.9e-17 62.8 0.0 1.4 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EMC82740.1 - 0.0011 19.3 0.0 0.04 14.2 0.0 2.3 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Ax_dynein_light PF10211.9 EMC82741.1 - 1.7e-68 230.3 18.8 2e-68 230.0 18.8 1.0 1 0 0 1 1 1 1 Axonemal dynein light chain DivIC PF04977.15 EMC82741.1 - 0.019 14.7 2.9 0.019 14.7 2.9 2.4 2 0 0 2 2 2 0 Septum formation initiator Syntaxin-6_N PF09177.11 EMC82741.1 - 0.031 14.8 8.5 0.045 14.3 8.5 1.3 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Spc24 PF08286.11 EMC82741.1 - 0.76 10.1 8.8 1.3 9.3 8.8 1.4 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 PRKG1_interact PF15898.5 EMC82741.1 - 0.94 10.4 14.9 2.2 9.2 14.9 1.7 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Jnk-SapK_ap_N PF09744.9 EMC82741.1 - 1.2 9.3 19.9 6.7 6.9 19.9 2.0 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 GrpE PF01025.19 EMC82741.1 - 1.8 8.2 12.7 2.8 7.6 12.1 1.6 1 1 1 2 2 2 0 GrpE NGP1NT PF08153.12 EMC82742.1 - 2.4e-48 163.6 0.9 6.5e-48 162.2 0.9 1.8 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 EMC82742.1 - 2.2e-17 63.2 0.4 6.6e-13 48.7 0.0 3.5 3 0 0 3 3 3 3 50S ribosome-binding GTPase FeoB_N PF02421.18 EMC82742.1 - 1.7e-05 24.4 0.0 8.5e-05 22.1 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EMC82742.1 - 0.00013 21.9 0.0 0.00058 19.8 0.0 2.1 1 1 0 1 1 1 1 RsgA GTPase Arf PF00025.21 EMC82742.1 - 0.01 15.3 0.1 0.3 10.5 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family Dynamin_N PF00350.23 EMC82742.1 - 0.23 11.5 9.3 0.18 11.9 1.0 4.4 3 1 0 3 3 3 0 Dynamin family Furin-like_2 PF15913.5 EMC82743.1 - 3.7e-49 165.4 22.2 3.7e-49 165.4 22.2 2.0 2 0 0 2 2 2 1 Furin-like repeat, cysteine-rich TSP_1 PF00090.19 EMC82743.1 - 0.00014 22.0 4.2 0.00014 22.0 4.2 3.7 3 1 1 4 4 4 1 Thrombospondin type 1 domain CK2S PF15011.6 EMC82744.1 - 0.00081 19.3 0.0 0.0012 18.7 0.0 1.3 1 0 0 1 1 1 1 Casein Kinase 2 substrate Scm3 PF10384.9 EMC82744.1 - 0.052 13.3 0.0 0.081 12.7 0.0 1.4 1 0 0 1 1 1 0 Centromere protein Scm3 Borealin PF10512.9 EMC82745.1 - 6.2e-28 97.2 0.0 1e-27 96.6 0.0 1.2 1 0 0 1 1 1 1 Cell division cycle-associated protein 8 DUF2576 PF10845.8 EMC82745.1 - 0.083 12.5 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2576) Axin_b-cat_bind PF08833.10 EMC82745.1 - 0.12 12.5 1.2 0.77 9.9 0.0 2.6 2 1 1 3 3 3 0 Axin beta-catenin binding domain Sua5_yciO_yrdC PF01300.18 EMC82746.1 - 2.3e-25 89.2 0.0 2.7e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 Telomere recombination zf-C2H2 PF00096.26 EMC82747.1 - 6.3e-28 95.6 40.3 7.9e-05 22.9 1.3 6.6 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC82747.1 - 8.5e-26 89.2 44.7 1.5e-07 31.5 0.5 7.4 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC82747.1 - 1.1e-17 63.2 37.3 0.0077 17.0 0.9 7.0 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EMC82747.1 - 2.9e-10 40.3 22.4 0.00027 21.2 5.1 3.9 1 1 3 4 4 4 4 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 EMC82747.1 - 5.3e-05 23.4 26.5 0.03 14.6 1.8 6.6 7 0 0 7 7 7 3 Zinc-finger double-stranded RNA-binding Marek_A PF02124.15 EMC82747.1 - 0.0037 17.1 3.8 0.34 10.7 0.2 2.7 2 1 1 3 3 3 2 Marek's disease glycoprotein A zf-C2H2_6 PF13912.6 EMC82747.1 - 0.0053 16.7 1.2 0.0053 16.7 1.2 5.5 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 EMC82747.1 - 0.32 11.1 19.3 2.9 8.0 0.3 5.1 1 1 4 5 5 5 0 Aberrant zinc-finger zf_ZIC PF18366.1 EMC82747.1 - 5.9 7.1 20.7 15 5.7 0.2 6.1 6 0 0 6 6 6 0 Zic proteins zinc finger domain Exo_endo_phos PF03372.23 EMC82748.1 - 2e-17 63.5 0.0 3.1e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RhoGAP PF00620.27 EMC82748.1 - 7.2e-17 61.6 0.0 1.4e-16 60.7 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 EMC82750.1 - 8.3e-49 163.7 70.3 2.4e-12 46.9 5.6 5.1 5 0 0 5 5 5 5 LIM domain Utp11 PF03998.13 EMC82752.1 - 7e-67 225.9 23.4 7.8e-67 225.8 23.4 1.0 1 0 0 1 1 1 1 Utp11 protein SLATT_5 PF18160.1 EMC82752.1 - 0.018 14.4 0.7 0.041 13.2 0.3 1.7 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF749 PF05370.11 EMC82752.1 - 0.19 11.8 0.2 0.19 11.8 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF749) Pou PF00157.17 EMC82753.1 - 7.4e-38 128.4 0.3 1.3e-37 127.5 0.3 1.4 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 EMC82753.1 - 3.1e-19 68.5 0.1 7.6e-19 67.3 0.1 1.7 1 0 0 1 1 1 1 Homeodomain HTH_31 PF13560.6 EMC82753.1 - 0.0001 22.6 0.0 0.019 15.3 0.0 2.2 2 0 0 2 2 2 2 Helix-turn-helix domain Homeobox_KN PF05920.11 EMC82753.1 - 0.0055 16.6 0.0 0.013 15.4 0.0 1.7 1 0 0 1 1 1 1 Homeobox KN domain Gtr1_RagA PF04670.12 EMC82754.1 - 6.8e-63 212.1 2.4 8.9e-63 211.7 2.4 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EMC82754.1 - 0.023 14.2 0.1 0.037 13.5 0.1 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family Roc PF08477.13 EMC82754.1 - 0.038 14.2 0.0 0.068 13.4 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase TSC22 PF01166.18 EMC82755.1 - 0.0057 16.9 0.7 0.0062 16.8 0.7 1.1 1 0 0 1 1 1 1 TSC-22/dip/bun family ZapB PF06005.12 EMC82755.1 - 0.015 15.8 2.7 0.015 15.7 2.7 1.1 1 0 0 1 1 1 0 Cell division protein ZapB Herpes_BLRF2 PF05812.12 EMC82755.1 - 0.015 15.4 1.3 0.016 15.3 1.3 1.0 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein HALZ PF02183.18 EMC82755.1 - 0.023 14.9 2.9 0.072 13.3 2.9 1.8 1 1 0 1 1 1 0 Homeobox associated leucine zipper Connexin PF00029.19 EMC82756.1 - 4.9e-98 327.6 0.4 5.5e-98 327.4 0.4 1.0 1 0 0 1 1 1 1 Connexin DUF4618 PF15397.6 EMC82756.1 - 0.0099 15.3 0.3 0.014 14.9 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) FHA PF00498.26 EMC82757.1 - 5.2e-16 58.7 0.1 1.2e-15 57.6 0.1 1.6 1 0 0 1 1 1 1 FHA domain Syntaxin_2 PF14523.6 EMC82759.1 - 1.1e-24 86.7 9.5 1.1e-24 86.7 9.5 2.5 2 1 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 EMC82759.1 - 5.4e-19 67.9 0.3 1.2e-18 66.8 0.3 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 EMC82759.1 - 6.9e-12 45.5 14.8 6.9e-12 45.5 14.8 1.6 2 1 0 2 2 2 1 Syntaxin Prominin PF05478.11 EMC82759.1 - 0.013 13.5 4.7 0.044 11.7 0.1 2.0 2 0 0 2 2 2 0 Prominin Sortilin-Vps10 PF15902.5 EMC82759.1 - 0.062 12.1 0.2 0.087 11.6 0.2 1.1 1 0 0 1 1 1 0 Sortilin, neurotensin receptor 3, ABC_tran_CTD PF16326.5 EMC82759.1 - 0.43 10.9 19.4 0.47 10.7 1.3 4.1 2 2 2 4 4 4 0 ABC transporter C-terminal domain T3SS_needle_E PF08988.10 EMC82759.1 - 0.89 9.7 0.1 0.89 9.7 0.1 3.1 3 0 0 3 3 3 0 Type III secretion system, cytoplasmic E component of needle Sec62 PF03839.16 EMC82759.1 - 0.96 8.9 0.0 0.96 8.9 0.0 2.2 2 1 0 2 2 2 0 Translocation protein Sec62 Synaptobrevin PF00957.21 EMC82759.1 - 1.2 8.9 10.8 0.97 9.3 2.4 2.8 2 1 0 2 2 2 0 Synaptobrevin GAS PF13851.6 EMC82759.1 - 5.2 6.4 21.0 3.2 7.1 9.5 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Dak2 PF02734.17 EMC82759.1 - 6.4 6.6 6.7 23 4.9 0.3 2.7 3 0 0 3 3 3 0 DAK2 domain zf-C4H2 PF10146.9 EMC82759.1 - 7.1 6.9 17.1 2.9 8.1 4.9 2.1 1 1 1 2 2 2 0 Zinc finger-containing protein Exonuc_VII_L PF02601.15 EMC82759.1 - 7.5 6.0 15.6 12 5.4 15.0 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit CITED PF04487.12 EMC82760.1 - 2.7e-80 269.7 14.7 3e-80 269.6 14.7 1.0 1 0 0 1 1 1 1 CITED Med15 PF09606.10 EMC82760.1 - 7.4 5.1 27.3 8.6 4.9 27.3 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal MBT PF02820.18 EMC82762.1 - 1.3e-49 166.4 0.0 9e-26 90.0 0.0 2.3 2 0 0 2 2 2 2 mbt repeat SLED PF12140.8 EMC82762.1 - 9.8e-37 125.9 0.1 1.6e-36 125.2 0.1 1.3 1 0 0 1 1 1 1 SLED domain SAM_1 PF00536.30 EMC82762.1 - 1.9e-16 60.2 0.1 3.9e-16 59.2 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RBR PF17208.3 EMC82762.1 - 3.7e-11 43.5 16.5 1.7e-10 41.4 16.5 2.3 1 0 0 1 1 1 1 RNA binding Region SAM_2 PF07647.17 EMC82762.1 - 4.5e-07 29.9 0.0 1.1e-06 28.7 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 EMC82762.1 - 0.00086 19.2 0.0 0.0016 18.4 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Endothelin PF00322.17 EMC82763.1 - 8.9e-22 76.4 17.8 5.9e-21 73.8 7.2 2.2 2 0 0 2 2 2 2 Endothelin family Serinc PF03348.15 EMC82765.1 - 8.8e-92 308.3 18.2 9.9e-92 308.1 18.2 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) Lipocalin PF00061.23 EMC82766.1 - 1e-22 80.9 0.7 1.2e-22 80.7 0.7 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 EMC82766.1 - 7.7e-05 22.6 0.9 0.0001 22.2 0.9 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Myosin_N PF02736.19 EMC82766.1 - 0.068 13.0 6.2 0.35 10.7 0.9 2.9 2 1 1 3 3 3 0 Myosin N-terminal SH3-like domain S1 PF00575.23 EMC82767.1 - 1.3e-10 41.5 0.0 2.7e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 S1 RNA binding domain zf-CCHC_3 PF13917.6 EMC82767.1 - 0.00045 20.1 1.5 0.00073 19.5 1.5 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 EMC82767.1 - 0.011 15.8 5.3 0.023 14.8 5.3 1.5 1 0 0 1 1 1 0 Zinc knuckle Herpes_UL55 PF04537.12 EMC82767.1 - 0.077 13.0 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus UL55 protein WD40 PF00400.32 EMC82768.1 - 3.7e-51 170.0 5.2 4.4e-07 30.5 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC82768.1 - 5.2e-16 58.7 0.1 0.002 18.4 0.0 5.7 3 3 3 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC82768.1 - 3.6e-09 36.8 0.2 0.0059 16.5 0.1 3.1 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EMC82768.1 - 5.8e-06 25.5 0.1 4.9 6.0 0.0 4.6 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 EMC82768.1 - 0.00036 19.2 0.1 0.3 9.6 0.0 2.2 2 0 0 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.8 EMC82768.1 - 0.0012 17.6 5.3 2.8 6.5 0.0 4.1 1 1 3 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 EMC82768.1 - 0.0079 15.6 0.0 1.2 8.3 0.1 2.3 1 1 1 2 2 2 2 WD40-like domain PD40 PF07676.12 EMC82768.1 - 0.079 12.9 0.0 0.91 9.5 0.1 2.5 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat NKAIN PF05640.14 EMC82769.1 - 6e-32 110.6 2.0 6.5e-32 110.5 2.0 1.0 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein NKAIN PF05640.14 EMC82770.1 - 1.8e-49 167.8 0.1 2e-49 167.7 0.1 1.0 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein PUF PF00806.19 EMC82771.1 - 8.7e-74 239.3 8.3 5.2e-09 35.3 0.1 8.4 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.11 EMC82771.1 - 0.039 14.3 0.6 4.6 7.6 0.1 3.6 1 1 1 3 3 3 0 CPL (NUC119) domain sCache_2 PF17200.4 EMC82771.1 - 0.093 12.6 0.1 54 3.6 0.0 3.6 4 0 0 4 4 4 0 Single Cache domain 2 Importin_rep_3 PF18806.1 EMC82771.1 - 0.13 12.3 0.2 0.78 9.8 0.0 2.3 2 0 0 2 2 2 0 Importin 13 repeat DUF4821 PF16092.5 EMC82771.1 - 0.19 11.3 0.1 0.44 10.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4821) Mt_ATP-synt_B PF05405.14 EMC82771.1 - 0.85 9.2 2.7 8.4 6.0 0.1 3.0 3 0 0 3 3 3 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) K_channel_TID PF07941.11 EMC82771.1 - 1.5 9.3 13.7 1.2 9.7 3.9 2.7 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain Mtp PF03821.16 EMC82774.1 - 5.8e-106 353.3 11.5 6.7e-106 353.1 11.5 1.0 1 0 0 1 1 1 1 Golgi 4-transmembrane spanning transporter DUF4728 PF15860.5 EMC82774.1 - 0.0058 17.3 20.9 0.031 14.9 6.2 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF4728) DUF1475 PF07343.11 EMC82774.1 - 0.72 9.6 8.1 0.11 12.3 2.9 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1475) VWA PF00092.28 EMC82775.1 - 1.2e-102 341.5 4.2 8.3e-54 182.5 0.5 2.1 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 EMC82775.1 - 1.6e-38 131.6 0.2 1.4e-18 67.4 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_3 PF13768.6 EMC82775.1 - 1.9e-14 53.9 0.0 1.7e-06 28.0 0.0 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain Matrilin_ccoil PF10393.9 EMC82775.1 - 1.3e-10 41.0 2.8 4.1e-10 39.4 2.8 2.0 1 0 0 1 1 1 1 Trimeric coiled-coil oligomerisation domain of matrilin FXa_inhibition PF14670.6 EMC82775.1 - 4.1e-10 39.8 8.6 8e-10 38.8 8.6 1.5 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site cEGF PF12662.7 EMC82775.1 - 4.4e-06 26.5 1.7 4.4e-06 26.5 1.7 1.9 2 0 0 2 2 2 1 Complement Clr-like EGF-like EGF_CA PF07645.15 EMC82775.1 - 5e-06 26.6 7.3 1.1e-05 25.6 7.3 1.5 1 0 0 1 1 1 1 Calcium-binding EGF domain Plasmod_Pvs28 PF06247.11 EMC82775.1 - 0.0027 18.0 5.4 0.0027 18.0 5.4 1.9 2 0 0 2 2 2 1 Pvs28 EGF domain EGF PF00008.27 EMC82775.1 - 0.0058 16.9 5.0 0.0058 16.9 5.0 1.8 2 0 0 2 2 1 1 EGF-like domain DUF2242 PF10001.9 EMC82775.1 - 0.014 15.6 0.2 3.1 8.0 0.0 2.7 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2242) Copine PF07002.16 EMC82775.1 - 0.019 14.5 0.0 0.76 9.2 0.0 2.4 2 0 0 2 2 2 0 Copine hEGF PF12661.7 EMC82775.1 - 0.052 14.2 0.3 0.052 14.2 0.3 2.5 3 0 0 3 3 2 0 Human growth factor-like EGF EGF_3 PF12947.7 EMC82775.1 - 1.1 9.5 15.2 0.13 12.5 10.7 1.8 2 0 0 2 2 2 0 EGF domain Methyltransf_23 PF13489.6 EMC82776.1 - 0.071 12.9 5.1 51 3.7 0.0 5.0 4 3 0 5 5 5 0 Methyltransferase domain ADH_zinc_N PF00107.26 EMC82778.1 - 4.6e-22 78.4 0.0 7e-22 77.8 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMC82778.1 - 1.2e-09 38.0 0.0 3.3e-09 36.6 0.0 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EMC82778.1 - 2.8e-07 31.6 0.0 5.2e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase CoA_binding_2 PF13380.6 EMC82778.1 - 0.01 16.3 0.1 0.021 15.3 0.1 1.7 1 1 0 1 1 1 0 CoA binding domain DUF4265 PF14085.6 EMC82778.1 - 0.072 13.1 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4265) PALP PF00291.25 EMC82778.1 - 0.086 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme Adeno_VII PF03228.14 EMC82778.1 - 0.16 12.6 0.0 0.31 11.7 0.0 1.4 1 0 0 1 1 1 0 Adenoviral core protein VII RRM_1 PF00076.22 EMC82779.1 - 1.9e-20 72.4 0.0 1e-13 50.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EMC82779.1 - 2.7e-05 24.2 0.0 8.9e-05 22.5 0.0 1.9 1 0 0 1 1 1 1 RNA binding motif MBT PF02820.18 EMC82780.1 - 6.3e-95 311.6 0.7 4.7e-30 103.7 0.0 3.2 3 0 0 3 3 3 3 mbt repeat zf-C2HC PF01530.18 EMC82780.1 - 2e-11 43.9 9.8 3.7e-11 43.0 9.8 1.5 1 0 0 1 1 1 1 Zinc finger, C2HC type Glyco_hydro_2_N PF02837.18 EMC82780.1 - 0.0099 15.8 0.1 4.8 7.1 0.0 2.8 3 0 0 3 3 3 2 Glycosyl hydrolases family 2, sugar binding domain Tudor-knot PF11717.8 EMC82780.1 - 0.27 11.1 5.7 0.73 9.8 0.6 3.0 3 0 0 3 3 3 0 RNA binding activity-knot of a chromodomain Nop14 PF04147.12 EMC82782.1 - 1.5e-07 30.1 44.0 1.7e-07 29.9 44.0 1.1 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.12 EMC82782.1 - 9.6e-06 25.3 47.7 1.1e-05 25.1 47.7 1.1 1 0 0 1 1 1 1 SDA1 BUD22 PF09073.10 EMC82782.1 - 0.018 14.4 47.9 0.022 14.1 47.9 1.1 1 0 0 1 1 1 0 BUD22 CCSAP PF15748.5 EMC82782.1 - 0.033 14.4 21.3 0.042 14.0 21.3 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Presenilin PF01080.17 EMC82782.1 - 0.056 12.2 27.8 0.07 11.9 27.8 1.0 1 0 0 1 1 1 0 Presenilin DUF4045 PF13254.6 EMC82782.1 - 0.17 11.5 19.9 0.19 11.4 19.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) FRQ PF09421.10 EMC82782.1 - 0.21 9.6 20.2 0.24 9.4 20.2 1.1 1 0 0 1 1 1 0 Frequency clock protein Hid1 PF12722.7 EMC82782.1 - 0.46 8.6 22.9 0.52 8.4 22.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Raftlin PF15250.6 EMC82782.1 - 1.8 7.3 18.8 2 7.1 18.8 1.1 1 0 0 1 1 1 0 Raftlin CNDH2_C PF16858.5 EMC82782.1 - 2.2 8.1 27.4 3.5 7.4 27.4 1.3 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Lin-8 PF03353.15 EMC82782.1 - 2.2 7.8 26.2 3 7.3 26.2 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Apt1 PF10351.9 EMC82782.1 - 3.9 6.2 15.8 5.3 5.8 15.8 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain CDC27 PF09507.10 EMC82782.1 - 4.5 6.5 40.7 5 6.4 40.7 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SAPS PF04499.15 EMC82782.1 - 5.3 5.7 27.5 6.1 5.5 27.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein LAP1C PF05609.12 EMC82782.1 - 6.9 5.6 23.1 8.7 5.3 23.1 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SLC12 PF03522.15 EMC82782.1 - 7.1 5.5 20.8 9 5.2 20.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 GAGA_bind PF06217.12 EMC82782.1 - 8.4 6.6 12.4 12 6.1 12.4 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DUF2371 PF10177.9 EMC82783.1 - 2.3e-31 108.9 0.0 3.4e-31 108.3 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2371) PIRT PF15099.6 EMC82783.1 - 0.047 13.3 0.6 0.094 12.3 0.6 1.5 1 1 0 1 1 1 0 Phosphoinositide-interacting protein family Neurensin PF14927.6 EMC82783.1 - 0.38 10.4 2.3 0.81 9.4 2.3 1.6 1 1 0 1 1 1 0 Neurensin Cys_knot PF00007.22 EMC82784.1 - 8.3e-13 48.5 8.8 8.3e-13 48.5 8.8 4.0 3 1 0 4 4 4 1 Cystine-knot domain IGFBP PF00219.18 EMC82784.1 - 1.5e-10 41.6 22.4 1.5e-10 41.6 22.4 5.9 3 2 3 6 6 6 1 Insulin-like growth factor binding protein VWC PF00093.18 EMC82784.1 - 0.022 15.1 12.3 0.022 15.1 12.3 5.7 4 3 0 4 4 4 0 von Willebrand factor type C domain Trnau1ap PF17654.1 EMC82785.1 - 3.3e-42 143.5 20.0 5.3e-42 142.9 20.0 1.3 1 0 0 1 1 1 1 Selenocysteine tRNA 1 associated proteins RRM_1 PF00076.22 EMC82785.1 - 2.1e-24 85.1 0.0 2.1e-12 46.6 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RPA_C PF08784.11 EMC82786.1 - 5.6e-23 81.6 0.3 1.6e-22 80.2 0.1 1.8 1 1 1 2 2 2 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 EMC82786.1 - 0.00021 21.2 0.0 0.00037 20.4 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RMI2 PF16100.5 EMC82786.1 - 0.0057 16.5 0.3 0.27 11.0 0.0 2.3 1 1 1 2 2 2 1 RecQ-mediated genome instability protein 2 TFA2_Winged_2 PF18121.1 EMC82786.1 - 0.046 13.4 0.0 0.14 11.9 0.0 1.7 1 1 0 1 1 1 0 TFA2 Winged helix domain 2 Haspin_kinase PF12330.8 EMC82786.1 - 0.051 12.5 0.1 0.076 11.9 0.0 1.5 2 0 0 2 2 2 0 Haspin like kinase domain LexA_DNA_bind PF01726.16 EMC82786.1 - 0.08 12.7 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 LexA DNA binding domain Metallophos PF00149.28 EMC82787.1 - 5.2e-11 43.4 1.1 7.8e-11 42.8 1.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase XK-related PF09815.9 EMC82788.1 - 9.6e-73 245.2 14.9 1.2e-72 244.9 14.9 1.0 1 0 0 1 1 1 1 XK-related protein TFIID_20kDa PF03847.13 EMC82789.1 - 3.6e-36 123.5 2.8 5e-36 123.0 2.8 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.23 EMC82789.1 - 6.7e-06 26.3 0.2 1e-05 25.7 0.2 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EMC82789.1 - 4.1e-05 24.0 0.2 4.1e-05 24.0 0.2 1.6 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 EMC82789.1 - 0.00011 22.3 0.2 0.00022 21.3 0.1 1.5 1 1 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 EMC82789.1 - 0.0056 16.8 0.1 0.0096 16.0 0.1 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF4 PF05236.14 EMC82789.1 - 0.0094 15.7 0.0 0.012 15.4 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family Ras PF00071.22 EMC82790.1 - 3.3e-48 163.3 0.0 3.9e-48 163.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC82790.1 - 2.5e-27 95.5 0.0 4.8e-27 94.6 0.0 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC82790.1 - 2.6e-11 43.3 0.0 3.2e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC82790.1 - 1.4e-05 25.2 0.0 2.2e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMC82790.1 - 0.0038 16.6 0.0 0.0052 16.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EMC82790.1 - 0.1 12.5 0.0 0.4 10.6 0.0 1.9 1 1 1 2 2 2 0 RsgA GTPase FeoB_N PF02421.18 EMC82790.1 - 0.11 12.0 0.0 15 5.1 0.0 2.7 2 1 0 2 2 2 0 Ferrous iron transport protein B Ras PF00071.22 EMC82791.1 - 8.7e-42 142.5 0.0 1e-41 142.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC82791.1 - 5.3e-21 75.1 0.0 9.5e-21 74.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC82791.1 - 1.2e-06 28.1 0.0 1.8e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC82791.1 - 0.00078 19.5 0.0 0.0013 18.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMC82791.1 - 0.0097 15.3 0.0 0.017 14.5 0.0 1.7 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 EMC82791.1 - 0.011 16.2 0.0 0.013 15.9 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain Trypan_PARP PF05887.11 EMC82792.1 - 0.00032 20.7 54.8 0.16 12.0 24.7 2.2 1 1 1 2 2 2 2 Procyclic acidic repetitive protein (PARP) Recep_L_domain PF01030.24 EMC82794.1 - 5.8e-31 106.9 0.3 7e-31 106.7 0.3 1.1 1 0 0 1 1 1 1 Receptor L domain zf-H2C2 PF09337.10 EMC82794.1 - 0.095 12.9 0.6 0.27 11.5 0.0 2.0 3 0 0 3 3 3 0 H2C2 zinc finger Pkinase_Tyr PF07714.17 EMC82797.1 - 1.2e-47 162.4 0.0 1.4e-47 162.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC82797.1 - 6.4e-18 65.1 0.0 7.6e-18 64.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 EMC82797.1 - 0.019 14.3 0.0 0.029 13.7 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 EMC82797.1 - 0.16 10.9 0.0 0.18 10.7 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain EF-hand_6 PF13405.6 EMC82799.1 - 2.4e-11 42.6 0.2 1.7e-06 27.5 0.1 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 EMC82799.1 - 4.8e-11 41.4 0.4 1.5e-05 24.2 0.1 3.2 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 EMC82799.1 - 0.00013 22.3 0.0 0.0019 18.6 0.0 2.2 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EMC82799.1 - 0.0018 17.6 0.7 0.014 14.9 0.3 2.3 2 0 0 2 2 2 1 EF hand EF-hand_9 PF14658.6 EMC82799.1 - 0.0025 18.1 0.0 0.027 14.8 0.0 2.2 2 1 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 EMC82799.1 - 0.023 14.5 0.1 5.5 6.9 0.0 3.1 3 0 0 3 3 3 0 EF-hand domain pair USP8_interact PF08941.10 EMC82800.1 - 2.2e-75 252.4 1.0 2.6e-75 252.2 1.0 1.0 1 0 0 1 1 1 1 USP8 interacting Trimer_CC PF08954.11 EMC82800.1 - 0.0019 17.7 0.2 0.0044 16.5 0.2 1.6 1 0 0 1 1 1 1 Trimerisation motif 7tm_4 PF13853.6 EMC82804.1 - 3.8e-24 85.9 2.6 4.2e-24 85.7 2.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC82804.1 - 0.0051 16.2 4.3 0.0099 15.2 4.3 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) MAJIN PF15077.6 EMC82805.1 - 1.5e-15 57.7 0.4 1.6e-15 57.6 0.4 1.1 1 0 0 1 1 1 1 Membrane-anchored junction protein UDPGT PF00201.18 EMC82807.1 - 2.8e-80 270.5 0.0 3.1e-80 270.4 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase UDPGT PF00201.18 EMC82808.1 - 3.5e-40 138.3 0.0 3.8e-40 138.1 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase UDPGT PF00201.18 EMC82809.1 - 1.3e-38 133.1 0.0 1.4e-38 132.9 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase UDPGT PF00201.18 EMC82810.1 - 7.2e-77 259.3 0.0 8.9e-77 259.0 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_4 PF13439.6 EMC82810.1 - 0.049 13.6 0.0 0.23 11.4 0.0 2.1 1 1 0 1 1 1 0 Glycosyltransferase Family 4 UDPGT PF00201.18 EMC82811.1 - 7.2e-79 265.9 0.1 8.1e-79 265.7 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_trans_4_2 PF13477.6 EMC82811.1 - 0.00065 19.7 0.0 0.037 14.1 0.0 2.2 1 1 0 1 1 1 1 Glycosyl transferase 4-like Glyco_transf_4 PF13439.6 EMC82811.1 - 0.014 15.4 0.0 0.12 12.4 0.0 2.1 1 1 0 1 1 1 0 Glycosyltransferase Family 4 SurE PF01975.17 EMC82811.1 - 0.098 12.4 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Survival protein SurE UDPGT PF00201.18 EMC82812.1 - 4.1e-75 253.5 0.0 4.6e-75 253.3 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_trans_4_2 PF13477.6 EMC82812.1 - 0.0085 16.1 0.0 0.026 14.6 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferase 4-like Glyco_transf_4 PF13439.6 EMC82812.1 - 0.022 14.8 0.1 0.032 14.2 0.1 1.4 1 1 0 1 1 1 0 Glycosyltransferase Family 4 Glyco_transf_5 PF08323.11 EMC82812.1 - 0.056 13.1 0.1 0.1 12.3 0.0 1.4 2 0 0 2 2 2 0 Starch synthase catalytic domain UDPGT PF00201.18 EMC82813.1 - 1e-213 710.7 0.2 1.2e-213 710.5 0.2 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EMC82813.1 - 7.7e-06 26.0 0.0 1.4e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Herpes_LMP2 PF07415.11 EMC82813.1 - 0.074 11.8 0.8 0.1 11.4 0.8 1.1 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein SurE PF01975.17 EMC82813.1 - 0.08 12.7 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Survival protein SurE Glyco_transf_4 PF13439.6 EMC82813.1 - 0.087 12.8 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Pro_3_hydrox_C PF05373.11 EMC82813.1 - 0.16 12.1 0.0 0.35 11.0 0.0 1.5 1 0 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal UCH PF00443.29 EMC82814.1 - 3.2e-39 135.0 0.3 1.4e-33 116.5 0.1 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMC82814.1 - 7.8e-18 65.1 0.2 1.1e-16 61.4 0.2 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Thioredoxin_7 PF13899.6 EMC82815.1 - 1.4e-23 82.8 0.0 2e-23 82.4 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EMC82815.1 - 0.0085 16.5 0.0 0.029 14.8 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredox_DsbH PF03190.15 EMC82815.1 - 0.078 12.9 0.0 0.11 12.5 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function, DUF255 Ank_2 PF12796.7 EMC82816.1 - 2.1e-23 82.7 0.0 2e-12 47.5 0.0 3.7 2 2 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC82816.1 - 9e-19 65.6 3.8 0.00081 19.7 0.0 5.6 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 EMC82816.1 - 1.4e-18 66.4 5.0 0.00034 20.9 0.0 5.4 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 EMC82816.1 - 3.8e-15 55.8 1.3 3.3e-05 24.1 0.1 4.8 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC82816.1 - 1.5e-13 50.9 1.3 2.7e-07 31.0 0.0 4.7 2 2 2 4 4 4 3 Ankyrin repeats (many copies) SOCS_box PF07525.16 EMC82816.1 - 5.4e-08 33.1 3.4 1.1e-07 32.1 3.4 1.5 1 0 0 1 1 1 1 SOCS box HLH PF00010.26 EMC82818.1 - 1.4e-15 56.9 0.6 3e-15 55.9 0.6 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain HTH_51 PF18558.1 EMC82818.1 - 0.0033 17.3 0.0 0.005 16.7 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain DUF773 PF05600.12 EMC82818.1 - 0.019 13.7 0.8 0.023 13.4 0.8 1.1 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 GDH_N PF12466.8 EMC82818.1 - 0.05 13.8 0.1 0.076 13.2 0.1 1.3 1 0 0 1 1 1 0 Glutamate dehydrogenase N terminal L27 PF02828.16 EMC82818.1 - 0.1 12.4 0.3 5.5 6.8 0.0 2.5 2 0 0 2 2 2 0 L27 domain Hist_deacetyl PF00850.19 EMC82819.1 - 1.3e-83 281.0 6.1 9.4e-83 278.2 0.0 2.6 2 0 0 2 2 2 1 Histone deacetylase domain HDAC4_Gln PF12203.8 EMC82819.1 - 8.1e-35 118.9 46.0 8.1e-35 118.9 46.0 3.6 2 1 1 3 3 3 1 Glutamine rich N terminal domain of histone deacetylase 4 dNK PF01712.19 EMC82820.1 - 3.7e-35 121.6 0.0 4.7e-35 121.3 0.0 1.1 1 0 0 1 1 1 1 Deoxynucleoside kinase Thymidylate_kin PF02223.17 EMC82820.1 - 0.00028 20.6 0.2 0.0015 18.2 0.2 2.2 1 1 0 1 1 1 1 Thymidylate kinase SKI PF01202.22 EMC82820.1 - 0.00088 19.4 0.1 0.42 10.7 0.1 2.7 3 0 0 3 3 3 2 Shikimate kinase AAA_17 PF13207.6 EMC82820.1 - 0.03 14.7 0.1 8.3 6.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EMC82820.1 - 0.063 13.3 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Cytidylate_kin2 PF13189.6 EMC82820.1 - 0.068 13.3 0.0 0.38 10.9 0.0 2.0 2 0 0 2 2 2 0 Cytidylate kinase-like family Cytidylate_kin PF02224.18 EMC82820.1 - 0.077 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Cytidylate kinase PAS_3 PF08447.12 EMC82821.1 - 5.1e-18 65.1 0.1 3.4e-11 43.3 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 EMC82821.1 - 3.8e-10 39.9 0.0 1.4e-07 31.6 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 EMC82821.1 - 6.8e-08 32.5 0.0 1.9e-07 31.0 0.0 1.7 1 0 0 1 1 1 1 PAS fold HLH PF00010.26 EMC82821.1 - 0.00013 21.8 0.0 0.00025 20.9 0.0 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.7 EMC82821.1 - 0.003 17.8 0.0 0.017 15.3 0.0 2.3 3 0 0 3 3 3 1 PAS domain PAS_3 PF08447.12 EMC82822.1 - 2e-12 47.2 0.0 3.4e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.6 EMC82822.1 - 1.1e-09 38.4 0.0 2e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EMC82822.1 - 0.0042 17.1 0.0 0.16 12.0 0.0 2.4 2 0 0 2 2 2 1 PAS fold HEAT PF02985.22 EMC82823.1 - 0.0067 16.6 0.2 18 5.9 0.0 3.4 3 0 0 3 3 3 2 HEAT repeat Adaptin_N PF01602.20 EMC82823.1 - 0.011 14.4 0.0 0.012 14.2 0.0 1.1 1 0 0 1 1 1 0 Adaptin N terminal region Cnd1 PF12717.7 EMC82823.1 - 0.1 12.6 0.1 0.16 12.0 0.1 1.4 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 Plexin_cytopl PF08337.12 EMC82824.1 - 1.6e-262 872.1 2.7 2e-262 871.8 2.7 1.1 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain TIG PF01833.24 EMC82824.1 - 9.3e-44 147.4 4.7 1.4e-13 50.7 0.1 6.1 6 0 0 6 6 6 4 IPT/TIG domain TIG_2 PF18020.1 EMC82824.1 - 2.6e-35 120.9 0.2 4.2e-34 117.0 0.1 2.9 2 0 0 2 2 2 1 TIG domain found in plexin PSI PF01437.25 EMC82824.1 - 4.4e-23 81.6 55.9 1.9e-10 41.1 15.3 3.6 3 0 0 3 3 3 3 Plexin repeat TIG_plexin PF17960.1 EMC82824.1 - 3.7e-22 78.1 9.7 1.3e-20 73.2 0.1 5.0 6 0 0 6 6 6 2 TIG domain PSI_integrin PF17205.3 EMC82824.1 - 0.00054 19.6 49.3 0.0012 18.6 13.8 3.6 3 0 0 3 3 3 3 Integrin plexin domain RasGAP PF00616.19 EMC82824.1 - 0.0022 17.7 1.0 0.46 10.2 0.9 2.7 2 1 0 2 2 2 2 GTPase-activator protein for Ras-like GTPase Sema PF01403.19 EMC82825.1 - 3.8e-63 213.8 0.0 5e-63 213.4 0.0 1.1 1 0 0 1 1 1 1 Sema domain DUF737 PF05300.11 EMC82826.1 - 9e-35 120.9 21.7 9.8e-35 120.7 21.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF737) Jnk-SapK_ap_N PF09744.9 EMC82826.1 - 0.0085 16.3 13.6 0.0095 16.2 13.6 1.1 1 0 0 1 1 1 1 JNK_SAPK-associated protein-1 DNA_photolyase PF00875.18 EMC82826.1 - 0.024 14.6 2.4 0.027 14.5 2.4 1.1 1 0 0 1 1 1 0 DNA photolyase Replicase PF03090.17 EMC82826.1 - 0.054 13.3 0.1 0.065 13.1 0.1 1.1 1 0 0 1 1 1 0 Replicase family HAUS6_N PF14661.6 EMC82826.1 - 0.085 12.4 6.3 0.094 12.3 6.3 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF2570 PF10828.8 EMC82826.1 - 0.11 12.3 6.5 0.056 13.3 4.6 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) ECH_2 PF16113.5 EMC82826.1 - 0.11 11.9 1.9 0.11 11.9 1.9 1.1 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase Tho2 PF11262.8 EMC82826.1 - 0.26 10.5 5.7 0.28 10.3 5.7 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 IgaA PF07095.11 EMC82826.1 - 0.48 8.3 2.3 0.53 8.2 2.3 1.0 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA ZnuA PF01297.17 EMC82826.1 - 2.2 7.6 6.1 3.6 6.9 6.1 1.5 1 1 0 1 1 1 0 Zinc-uptake complex component A periplasmic rRNA_processing PF08524.11 EMC82826.1 - 2.5 8.1 16.2 2.8 8.0 16.2 1.1 1 0 0 1 1 1 0 rRNA processing Exonuc_VII_L PF02601.15 EMC82826.1 - 6.8 6.2 9.2 6.7 6.2 9.2 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Ets PF00178.22 EMC82827.1 - 5.4e-29 100.5 1.2 1.2e-28 99.3 1.2 1.6 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.16 EMC82827.1 - 5.1e-27 93.7 0.0 8.5e-27 93.0 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_3 PF18016.1 EMC82827.1 - 0.00058 19.6 0.0 0.0011 18.7 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EMC82827.1 - 0.12 12.8 0.7 0.38 11.2 0.7 1.8 1 1 0 1 1 1 0 SAM domain (Sterile alpha motif) PARP PF00644.20 EMC82828.1 - 7.7e-41 139.8 0.6 1.8e-40 138.7 0.6 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.20 EMC82828.1 - 3e-17 63.0 2.0 2.2e-16 60.2 0.6 2.7 2 0 0 2 2 2 1 WWE domain zf-CCCH_8 PF18633.1 EMC82828.1 - 0.022 14.8 1.4 0.022 14.8 1.4 2.9 2 0 0 2 2 2 0 Zinc-finger antiviral protein (ZAP) zinc finger domain 3 TPR_14 PF13428.6 EMC82829.1 - 6.1e-05 23.5 0.0 9.7 7.3 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EMC82829.1 - 0.00048 20.6 0.1 8 7.3 0.0 5.1 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 EMC82829.1 - 0.0021 18.0 4.9 11 6.4 0.0 4.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EMC82829.1 - 0.0034 16.8 1.2 0.063 12.7 0.0 2.8 3 1 0 3 3 3 1 MalT-like TPR region PKD_channel PF08016.12 EMC82830.1 - 1.4e-110 369.9 11.9 1.4e-110 369.9 11.9 1.8 2 0 0 2 2 2 1 Polycystin cation channel REJ PF02010.15 EMC82830.1 - 3.1e-93 313.0 2.3 5.3e-93 312.3 2.3 1.4 1 0 0 1 1 1 1 REJ domain PLAT PF01477.23 EMC82830.1 - 1.6e-20 73.8 1.1 3.6e-20 72.7 0.1 2.2 2 0 0 2 2 2 1 PLAT/LH2 domain Ion_trans PF00520.31 EMC82830.1 - 1.2e-09 37.7 21.1 1.2e-09 37.7 21.1 2.7 3 0 0 3 3 3 1 Ion transport protein C6_DPF PF10170.9 EMC82831.1 - 6e-41 138.7 5.6 7.6e-41 138.4 5.6 1.1 1 0 0 1 1 1 1 Cysteine-rich domain zf-C4 PF00105.18 EMC82832.1 - 1.2e-28 99.4 16.1 2.2e-28 98.5 16.1 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 EMC82832.1 - 3.5e-16 59.4 0.1 7.3e-16 58.4 0.1 1.5 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor wnt PF00110.19 EMC82833.1 - 9.4e-125 416.3 26.3 1.1e-124 416.1 26.3 1.0 1 0 0 1 1 1 1 wnt family Atx10homo_assoc PF09759.9 EMC82834.1 - 6.1e-40 135.3 14.0 1.3e-38 131.0 0.8 4.5 4 1 0 4 4 4 2 Spinocerebellar ataxia type 10 protein domain DUF484 PF04340.12 EMC82834.1 - 0.0043 16.8 0.4 0.0043 16.8 0.4 1.5 2 0 0 2 2 2 1 Protein of unknown function, DUF484 Coatamer_beta_C PF07718.12 EMC82834.1 - 0.049 13.5 0.1 0.13 12.2 0.1 1.7 1 0 0 1 1 1 0 Coatomer beta C-terminal region EGF_CA PF07645.15 EMC82835.1 - 3e-68 225.8 140.7 3.1e-11 43.3 5.1 10.7 11 1 1 12 12 12 9 Calcium-binding EGF domain cEGF PF12662.7 EMC82835.1 - 6.7e-57 189.0 67.7 3.8e-09 36.3 0.7 10.0 9 0 0 9 9 9 8 Complement Clr-like EGF-like FXa_inhibition PF14670.6 EMC82835.1 - 8.5e-26 90.0 138.2 1.7e-06 28.2 9.1 11.2 11 2 0 11 11 11 7 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 EMC82835.1 - 1.8e-16 60.0 103.3 0.00017 21.7 6.1 10.5 9 0 0 9 9 9 9 EGF domain ANATO PF01821.18 EMC82835.1 - 9e-06 26.5 18.9 0.00052 20.8 6.0 9.4 9 1 1 10 10 10 2 Anaphylotoxin-like domain EGF PF00008.27 EMC82835.1 - 0.00028 21.1 122.1 0.0052 17.0 8.3 11.3 10 0 0 10 10 10 7 EGF-like domain hEGF PF12661.7 EMC82835.1 - 0.011 16.3 6.7 0.011 16.3 6.7 12.5 12 1 0 12 12 12 0 Human growth factor-like EGF GBP_PSP PF02425.15 EMC82835.1 - 3 7.6 14.9 0.48 10.1 1.4 4.4 4 0 0 4 4 4 0 Paralytic/GBP/PSP peptide RIB43A PF05914.12 EMC82836.1 - 1.3e-144 481.6 60.7 1.6e-144 481.3 60.7 1.0 1 0 0 1 1 1 1 RIB43A SIR2_2 PF13289.6 EMC82837.1 - 5.6e-18 65.4 0.0 1.4e-17 64.2 0.0 1.6 1 0 0 1 1 1 1 SIR2-like domain STI1 PF17830.1 EMC82837.1 - 0.055 13.4 0.2 4.9 7.2 0.0 2.6 2 0 0 2 2 2 0 STI1 domain Uroplakin_II PF07353.12 EMC82838.1 - 0.00019 21.0 0.2 0.00039 20.0 0.0 1.7 2 0 0 2 2 2 1 Uroplakin II DUF2045 PF09741.9 EMC82839.1 - 1.1e-96 322.8 1.3 1.3e-96 322.5 1.3 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2045) NUP50 PF08911.11 EMC82840.1 - 4e-22 78.7 0.9 4e-22 78.7 0.9 3.1 4 0 0 4 4 4 1 NUP50 (Nucleoporin 50 kDa) Ran_BP1 PF00638.18 EMC82840.1 - 1.3e-10 41.6 0.0 2.4e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 RanBP1 domain PHD PF00628.29 EMC82842.1 - 2.6e-07 30.4 7.0 5.4e-07 29.4 7.0 1.5 1 0 0 1 1 1 1 PHD-finger Zf_RING PF16744.5 EMC82842.1 - 1.8 8.7 7.0 8.9 6.5 7.0 2.2 1 1 0 1 1 1 0 KIAA1045 RING finger zf-rbx1 PF12678.7 EMC82842.1 - 2.6 8.4 8.7 6.5 7.1 8.7 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain BES1_N PF05687.13 EMC82842.1 - 3.3 8.1 11.6 4.8 7.5 0.4 2.8 2 0 0 2 2 2 0 BES1/BZR1 plant transcription factor, N-terminal CRAL_TRIO_2 PF13716.6 EMC82843.1 - 4.7e-38 130.4 3.5 8.2e-38 129.7 3.5 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain RhoGAP PF00620.27 EMC82843.1 - 7.4e-29 100.5 0.1 1.2e-27 96.6 0.0 2.6 2 1 0 2 2 2 1 RhoGAP domain CRAL_TRIO PF00650.20 EMC82843.1 - 1e-12 48.0 0.5 2.1e-12 47.0 0.5 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain YvbH_ext PF11724.8 EMC82843.1 - 0.93 9.9 4.6 2.6 8.4 0.6 2.5 1 1 1 2 2 2 0 YvbH-like oligomerisation region RRM_1 PF00076.22 EMC82847.1 - 9.3e-12 44.6 0.5 1.4e-11 44.0 0.0 1.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 EMC82847.1 - 0.36 11.1 1.0 1.6 9.0 0.0 2.3 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter ADH_N PF08240.12 EMC82848.1 - 1.8e-24 85.7 0.1 4.3e-24 84.5 0.1 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMC82848.1 - 9.2e-22 77.4 0.6 1.6e-21 76.6 0.6 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EMC82848.1 - 1.4e-08 34.5 3.2 3.9e-08 33.0 1.7 2.2 2 1 0 2 2 2 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 EMC82848.1 - 0.00015 21.2 1.6 0.00024 20.5 1.6 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 EMC82848.1 - 0.037 15.1 0.0 0.073 14.1 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase DUF281 PF03436.13 EMC82848.1 - 0.078 13.4 0.9 0.33 11.4 0.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF281) DUF2249 PF10006.9 EMC82848.1 - 0.084 12.8 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2249) An_peroxidase PF03098.15 EMC82849.1 - 2.9e-133 445.3 0.0 4.2e-133 444.7 0.0 1.2 1 0 0 1 1 1 1 Animal haem peroxidase NAD_binding_6 PF08030.12 EMC82849.1 - 8.2e-31 107.2 0.2 3.7e-29 101.9 0.0 2.4 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EMC82849.1 - 2.5e-20 72.9 16.4 7.1e-20 71.4 16.4 1.9 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EMC82849.1 - 1.2e-18 67.2 0.0 3.9e-18 65.5 0.0 1.9 1 0 0 1 1 1 1 FAD-binding domain EF-hand_1 PF00036.32 EMC82849.1 - 2.2e-14 51.8 5.4 6e-07 28.6 0.5 3.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EMC82849.1 - 6.9e-11 42.4 5.9 2e-06 28.2 2.4 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EMC82849.1 - 9.9e-10 37.6 6.4 0.00061 19.5 0.4 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 EMC82849.1 - 1.6e-09 37.5 8.0 2.6e-05 24.0 0.2 3.7 1 1 2 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EMC82849.1 - 1.8e-07 30.3 2.6 0.0029 17.0 0.3 2.9 2 0 0 2 2 2 2 EF hand NAD_binding_1 PF00175.21 EMC82849.1 - 0.00013 22.6 0.3 0.054 14.1 0.0 3.5 3 0 0 3 3 3 1 Oxidoreductase NAD-binding domain DuoxA PF10204.9 EMC82850.1 - 2.5e-113 377.7 10.9 2.8e-113 377.6 10.9 1.0 1 0 0 1 1 1 1 Dual oxidase maturation factor DUF2371 PF10177.9 EMC82850.1 - 0.26 11.5 3.1 6.5 6.9 0.0 3.1 2 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) DuoxA PF10204.9 EMC82851.1 - 1.2e-95 319.8 9.7 5.8e-95 317.5 9.7 1.8 1 1 0 1 1 1 1 Dual oxidase maturation factor Neurensin PF14927.6 EMC82851.1 - 0.37 10.5 4.5 2.7 7.7 0.0 3.2 2 1 1 3 3 3 0 Neurensin Claudin_2 PF13903.6 EMC82851.1 - 0.39 10.4 18.4 0.09 12.5 3.9 2.7 2 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Peptidase_S24 PF00717.23 EMC82852.1 - 1.5e-09 37.6 0.1 2.5e-09 36.9 0.1 1.4 1 0 0 1 1 1 1 Peptidase S24-like zf-C2H2_11 PF16622.5 EMC82853.1 - 5.2e-16 58.1 4.7 5.2e-16 58.1 4.7 7.4 8 2 1 9 9 9 2 zinc-finger C2H2-type zf-C2H2_4 PF13894.6 EMC82853.1 - 2.3e-05 24.9 85.2 0.075 13.9 0.4 12.5 12 0 0 12 12 12 6 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC82853.1 - 0.00041 20.7 90.0 0.087 13.3 1.8 12.4 12 0 0 12 12 12 6 Zinc finger, C2H2 type HEPN_AbiU2 PF18734.1 EMC82853.1 - 0.04 13.4 0.4 0.068 12.7 0.4 1.3 1 0 0 1 1 1 0 AbiU2 Vps36-NZF-N PF16988.5 EMC82853.1 - 0.041 13.3 0.1 0.041 13.3 0.1 3.7 2 1 1 3 3 3 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Retinin_C PF04527.12 EMC82853.1 - 0.83 10.0 7.3 2.6 8.3 7.3 1.8 1 0 0 1 1 1 0 Drosophila Retinin like protein Nucleos_tra2_C PF07662.13 EMC82855.1 - 9.5e-77 257.5 7.0 2.9e-76 255.9 7.0 1.9 1 0 0 1 1 1 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 EMC82855.1 - 2.2e-21 76.2 5.6 2.2e-21 76.2 5.6 3.5 4 0 0 4 4 4 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.14 EMC82855.1 - 3e-09 37.1 6.7 3e-09 37.1 6.7 4.0 3 2 0 3 3 3 1 Nucleoside recognition SH2 PF00017.24 EMC82856.1 - 1.4e-16 60.3 0.0 2.1e-16 59.7 0.0 1.3 1 0 0 1 1 1 1 SH2 domain 7tm_4 PF13853.6 EMC82858.1 - 6.7e-57 193.3 12.0 7.7e-57 193.1 12.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC82858.1 - 1.4e-30 106.6 14.8 1.7e-30 106.2 14.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC82858.1 - 0.00074 19.0 13.3 0.0024 17.3 13.3 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC82858.1 - 0.0064 16.1 4.8 0.0064 16.1 4.8 2.0 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF4293 PF14126.6 EMC82858.1 - 0.93 9.7 4.8 0.12 12.6 0.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) 7tm_4 PF13853.6 EMC82859.1 - 2e-49 168.8 26.9 2.3e-49 168.6 26.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC82859.1 - 1.9e-30 106.1 29.6 2.6e-30 105.6 29.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3951 PF13131.6 EMC82859.1 - 0.0084 16.3 0.0 0.0084 16.3 0.0 3.8 4 0 0 4 4 4 1 Protein of unknown function (DUF3951) 7TM_GPCR_Srx PF10328.9 EMC82859.1 - 0.21 11.2 31.8 1 8.9 31.8 2.0 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx zf-RING_11 PF17123.5 EMC82860.1 - 1.6e-06 27.7 1.0 3.2e-06 26.8 1.0 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 EMC82860.1 - 0.00045 20.5 1.7 0.0007 19.9 1.7 1.5 1 0 0 1 1 1 1 Ring finger domain Baculo_RING PF05883.11 EMC82860.1 - 0.05 13.6 0.2 0.052 13.5 0.2 1.1 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain NACHT PF05729.12 EMC82861.1 - 3.9e-33 114.7 0.2 1.6e-32 112.7 0.0 2.2 2 0 0 2 2 2 1 NACHT domain LRR_6 PF13516.6 EMC82861.1 - 3.3e-21 73.5 2.7 0.0029 17.5 0.0 8.6 8 0 0 8 8 8 5 Leucine Rich repeat NLRC4_HD2 PF17776.1 EMC82861.1 - 5.1e-21 75.6 2.8 2e-20 73.6 2.8 2.1 1 0 0 1 1 1 1 NLRC4 helical domain HD2 CARD PF00619.21 EMC82861.1 - 2.8e-14 52.9 4.3 1e-13 51.1 0.1 3.6 4 0 0 4 4 4 1 Caspase recruitment domain NOD2_WH PF17779.1 EMC82861.1 - 3.3e-13 49.7 3.3 2.7e-12 46.8 0.3 3.7 3 0 0 3 3 3 1 NOD2 winged helix domain LRR_4 PF12799.7 EMC82861.1 - 1.9e-07 31.3 0.5 0.089 13.2 0.0 4.8 4 0 0 4 4 4 1 Leucine Rich repeats (2 copies) AAA_16 PF13191.6 EMC82861.1 - 0.0046 17.4 0.0 0.014 15.8 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain SpoU_sub_bind PF08032.12 EMC82861.1 - 0.026 14.8 1.5 4.7 7.6 0.0 3.9 3 1 0 4 4 4 0 RNA 2'-O ribose methyltransferase substrate binding AAA_22 PF13401.6 EMC82861.1 - 0.031 14.6 0.0 0.1 12.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain FumaraseC_C PF10415.9 EMC82861.1 - 0.05 14.0 0.2 0.8 10.2 0.1 2.9 2 1 0 2 2 2 0 Fumarase C C-terminus YozE_SAM_like PF06855.12 EMC82861.1 - 0.31 11.3 1.8 7.8 6.8 1.1 2.9 3 0 0 3 3 3 0 YozE SAM-like fold AIG2_2 PF13772.6 EMC82862.1 - 3.4e-29 101.1 0.0 4.5e-29 100.7 0.0 1.2 1 0 0 1 1 1 1 AIG2-like family GGACT PF06094.12 EMC82862.1 - 3.2e-06 27.7 0.0 5e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like GDA1_CD39 PF01150.17 EMC82864.1 - 2.3e-105 352.7 0.2 2.8e-105 352.4 0.2 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ribosomal_L14e PF01929.17 EMC82865.1 - 7.6e-31 106.4 8.6 1.2e-30 105.8 8.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 EMC82865.1 - 0.0071 16.3 0.1 0.012 15.6 0.1 1.4 1 0 0 1 1 1 1 KOW motif VSG_B PF13206.6 EMC82865.1 - 1 8.5 8.3 1.1 8.4 8.3 1.0 1 0 0 1 1 1 0 Trypanosomal VSG domain DUF563 PF04577.14 EMC82866.1 - 6.1e-21 75.5 0.1 1.2e-20 74.5 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Pkinase PF00069.25 EMC82867.1 - 1.8e-74 250.5 0.0 3.1e-74 249.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC82867.1 - 7.4e-42 143.4 0.0 1.1e-41 142.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC82867.1 - 7.5e-10 38.6 0.0 4.9e-09 35.9 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EMC82867.1 - 0.015 14.7 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Anoctamin PF04547.12 EMC82868.1 - 7.7e-106 354.6 23.4 1e-105 354.2 23.4 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel DUF898 PF05987.13 EMC82868.1 - 0.58 9.2 9.3 0.027 13.5 2.5 2.1 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF898) Abhydrolase_1 PF00561.20 EMC82869.1 - 3.7e-21 76.0 0.0 1.2e-20 74.2 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMC82869.1 - 3.4e-16 60.5 0.0 4.5e-16 60.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMC82869.1 - 2.1e-12 46.8 0.0 3e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 EMC82869.1 - 0.00098 17.9 0.0 0.0031 16.2 0.0 1.7 2 0 0 2 2 2 1 Ndr family Abhydrolase_3 PF07859.13 EMC82869.1 - 0.081 12.8 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF1071 PF06378.11 EMC82869.1 - 0.1 12.2 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1071) PAF-AH_p_II PF03403.13 EMC82869.1 - 0.1 11.1 0.0 0.2 10.2 0.0 1.4 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_2 PF02230.16 EMC82869.1 - 0.19 11.5 0.0 21 4.8 0.0 2.3 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase LSPR PF06049.12 EMC82869.1 - 1 9.4 0.1 1 9.4 0.1 2.5 3 0 0 3 3 3 0 Coagulation Factor V LSPD Repeat FRG1 PF06229.12 EMC82870.1 - 1.4e-80 269.5 1.2 1.4e-80 269.5 1.2 1.5 2 0 0 2 2 2 1 FRG1-like domain Fascin PF06268.13 EMC82870.1 - 6.8e-08 32.7 0.0 3.1e-07 30.6 0.0 2.1 3 0 0 3 3 3 1 Fascin domain DUF569 PF04601.13 EMC82870.1 - 0.00017 21.3 0.3 0.002 17.8 0.0 2.8 1 1 0 2 2 2 1 Domain of unknown function (DUF569) AIM3 PF17096.5 EMC82870.1 - 0.032 15.2 0.1 0.032 15.2 0.1 2.0 2 1 0 2 2 2 0 Altered inheritance of mitochondria protein 3 Jak1_Phl PF17887.1 EMC82870.1 - 0.081 12.9 0.1 0.081 12.9 0.1 2.2 2 0 0 2 2 2 0 Jak1 pleckstrin homology-like domain CBAH PF02275.18 EMC82871.1 - 6.8e-38 131.1 0.2 6.4e-36 124.6 0.2 2.1 1 1 0 1 1 1 1 Linear amide C-N hydrolases, choloylglycine hydrolase family NAAA-beta PF15508.6 EMC82871.1 - 8e-22 77.3 0.1 2.1e-21 76.0 0.1 1.7 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase AAT PF03417.16 EMC82871.1 - 0.062 13.0 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase TFIIE_alpha PF02002.17 EMC82872.1 - 5.8e-29 100.0 1.4 1.1e-28 99.2 1.4 1.5 1 0 0 1 1 1 1 TFIIE alpha subunit TFIIE-A_C PF11521.8 EMC82872.1 - 1.4e-27 95.8 3.1 1.4e-27 95.8 3.1 2.0 2 0 0 2 2 2 1 C-terminal general transcription factor TFIIE alpha TF_Zn_Ribbon PF08271.12 EMC82872.1 - 6.2e-07 28.8 0.9 1.4e-06 27.7 0.9 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding Elf1 PF05129.13 EMC82872.1 - 0.028 14.5 0.7 0.077 13.1 0.7 1.7 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like OrfB_Zn_ribbon PF07282.11 EMC82872.1 - 0.042 13.8 0.6 0.083 12.8 0.6 1.5 1 0 0 1 1 1 0 Putative transposase DNA-binding domain PyrI_C PF02748.15 EMC82872.1 - 2 8.4 4.7 2.8 7.9 3.2 2.1 2 1 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain PCM1_C PF15717.5 EMC82873.1 - 1.4e-269 896.2 50.7 1.4e-269 896.2 50.7 7.0 4 3 1 6 6 6 1 Pericentriolar material 1 C terminus IBN_N PF03810.19 EMC82873.1 - 9.5 6.2 21.8 0.23 11.4 0.3 5.0 4 0 0 4 4 4 0 Importin-beta N-terminal domain Fibrinogen_C PF00147.18 EMC82874.1 - 1.7e-78 263.4 11.3 2.1e-78 263.1 11.3 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Ig_3 PF13927.6 EMC82877.1 - 1.1e-18 67.5 1.1 8.1e-10 39.2 0.0 3.6 3 1 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 EMC82877.1 - 6.2e-15 55.1 0.1 1.9e-06 28.0 0.0 3.8 3 1 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 EMC82877.1 - 9.5e-15 54.4 0.1 1.1e-08 35.0 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC82877.1 - 1.2e-10 41.6 1.6 0.00031 21.0 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 EMC82877.1 - 0.00057 20.0 0.4 5.3 7.3 0.1 3.6 2 1 1 3 3 3 2 Immunoglobulin V-set domain Ig_6 PF18452.1 EMC82877.1 - 0.005 16.4 0.1 0.27 10.8 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain Izumo-Ig PF16706.5 EMC82877.1 - 0.0088 16.1 0.0 1.5 9.0 0.0 2.4 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain AA_permease_2 PF13520.6 EMC82878.1 - 8.7e-50 169.8 29.6 8.7e-50 169.8 29.6 2.2 2 1 0 2 2 2 1 Amino acid permease AA_permease PF00324.21 EMC82878.1 - 8.7e-34 116.9 27.5 8.7e-34 116.9 27.5 2.2 2 0 0 2 2 2 2 Amino acid permease AA_permease_C PF13906.6 EMC82878.1 - 1.8e-24 85.6 6.3 1.8e-24 85.6 6.3 3.6 3 0 0 3 3 3 1 C-terminus of AA_permease MAP17 PF15807.5 EMC82878.1 - 0.1 12.9 0.3 0.27 11.5 0.3 1.7 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF3043 PF11241.8 EMC82878.1 - 2.5 8.1 7.2 1.3 9.0 0.3 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) Myotub-related PF06602.14 EMC82879.1 - 4.2e-146 486.4 0.2 5.5e-146 486.0 0.2 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DSPc PF00782.20 EMC82879.1 - 0.0012 18.6 0.0 0.0028 17.5 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC82879.1 - 0.0071 15.9 0.0 0.017 14.7 0.0 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EMC82879.1 - 0.031 14.3 0.0 0.059 13.3 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF4416 PF14385.6 EMC82879.1 - 0.12 12.3 0.1 0.26 11.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4416) Mod_r PF07200.13 EMC82880.1 - 2.9e-38 131.2 15.5 3.8e-38 130.9 15.5 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein UEV PF05743.13 EMC82880.1 - 0.00038 20.3 5.7 0.00043 20.1 0.8 2.8 4 0 0 4 4 4 1 UEV domain UQ_con PF00179.26 EMC82880.1 - 2.5 7.8 4.9 0.54 9.9 1.1 1.8 2 0 0 2 2 2 0 Ubiquitin-conjugating enzyme CAF1 PF04857.20 EMC82881.1 - 1.2e-22 80.5 0.6 1.7e-11 43.8 0.1 2.5 1 1 1 2 2 2 2 CAF1 family ribonuclease DHHC PF01529.20 EMC82882.1 - 1.4e-35 122.3 14.2 1.4e-35 122.3 14.2 1.8 2 0 0 2 2 2 1 DHHC palmitoyltransferase Spt4 PF06093.13 EMC82882.1 - 1.3 9.2 6.8 2.5 8.3 6.8 1.5 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger EF-hand_8 PF13833.6 EMC82883.1 - 1.6e-16 59.9 8.1 1.4e-07 31.2 0.0 6.0 6 1 0 6 6 6 2 EF-hand domain pair EF-hand_7 PF13499.6 EMC82883.1 - 7.9e-14 51.9 14.0 1.1e-05 25.8 0.1 5.6 4 3 0 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 EMC82883.1 - 1.1e-10 40.6 11.5 0.00027 20.6 0.5 6.5 9 0 0 9 9 9 2 EF-hand domain EF-hand_1 PF00036.32 EMC82883.1 - 3.1e-09 35.7 21.0 9.8e-05 21.6 0.7 6.9 8 0 0 8 8 8 2 EF hand EF-hand_4 PF12763.7 EMC82883.1 - 0.0048 16.8 0.5 0.052 13.5 0.1 2.8 2 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.6 EMC82883.1 - 0.13 11.8 12.0 2.8 7.6 0.2 5.1 6 0 0 6 6 6 0 EF hand DUF4734 PF15881.5 EMC82883.1 - 0.22 11.7 1.7 22 5.3 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4734) FGF PF00167.18 EMC82884.1 - 4.2e-33 114.1 0.1 4.7e-33 113.9 0.1 1.0 1 0 0 1 1 1 1 Fibroblast growth factor OST3_OST6 PF04756.13 EMC82886.1 - 4.8e-112 374.1 0.1 5.4e-112 373.9 0.1 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin PF00085.20 EMC82886.1 - 3.2e-05 23.8 0.0 4.9e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin YhhN PF07947.14 EMC82886.1 - 0.098 12.3 3.4 0.41 10.2 3.4 1.9 1 1 0 1 1 1 0 YhhN family Gram_pos_anchor PF00746.21 EMC82886.1 - 0.1 12.5 0.4 0.1 12.5 0.4 2.1 2 0 0 2 2 2 0 LPXTG cell wall anchor motif DUF4131 PF13567.6 EMC82886.1 - 0.56 9.8 4.7 0.48 10.1 0.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Sarcoglycan_1 PF04790.13 EMC82887.1 - 6.1e-87 291.3 0.0 7.1e-87 291.1 0.0 1.0 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein DUF2345 PF10106.9 EMC82887.1 - 1.1e-05 25.4 0.1 0.0014 18.5 0.0 2.6 1 1 1 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2345) GST_N_5 PF18485.1 EMC82887.1 - 0.15 12.4 0.0 2.2 8.7 0.0 2.3 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain PRP38_assoc PF12871.7 EMC82889.1 - 6.3 7.5 128.7 93 3.7 53.8 3.5 1 1 1 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term START PF01852.19 EMC82890.1 - 5.7e-49 166.4 0.1 1e-48 165.5 0.1 1.4 1 0 0 1 1 1 1 START domain RhoGAP PF00620.27 EMC82890.1 - 1.4e-41 141.9 0.7 6e-41 139.8 0.8 2.0 2 0 0 2 2 2 1 RhoGAP domain SAM_2 PF07647.17 EMC82890.1 - 1.1e-06 28.6 0.0 7.9e-06 25.9 0.0 2.5 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Methyltransf_11 PF08241.12 EMC82891.1 - 3.3e-15 56.5 0.0 6.8e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC82891.1 - 2.1e-14 54.0 0.0 5.2e-14 52.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC82891.1 - 1.6e-09 37.8 0.0 3.3e-09 36.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC82891.1 - 2.4e-07 30.8 0.0 9.5e-07 28.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC82891.1 - 3.4e-07 30.9 0.0 2.4e-06 28.2 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMC82891.1 - 1.4e-06 27.8 0.0 3.1e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 EMC82891.1 - 0.00013 21.9 0.0 0.00022 21.2 0.0 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase CMAS PF02353.20 EMC82891.1 - 0.00065 19.1 0.2 0.017 14.4 0.2 2.3 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.11 EMC82891.1 - 0.012 14.5 0.0 0.13 11.2 0.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1698) SAICAR_synt PF01259.18 EMC82892.1 - 7.9e-55 186.2 0.1 1.1e-54 185.7 0.1 1.2 1 0 0 1 1 1 1 SAICAR synthetase AIRC PF00731.20 EMC82892.1 - 3e-39 133.9 0.0 5.2e-39 133.2 0.0 1.3 1 0 0 1 1 1 1 AIR carboxylase Myb_DNA-bind_4 PF13837.6 EMC82893.1 - 4.7e-20 71.8 3.7 5.2e-20 71.6 3.7 1.0 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_3 PF12776.7 EMC82893.1 - 0.00085 20.3 1.8 0.001 20.0 1.8 1.1 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.9 EMC82893.1 - 0.0015 18.8 2.8 0.0019 18.5 2.8 1.2 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_5 PF13873.6 EMC82893.1 - 0.0032 17.5 3.7 0.012 15.6 3.2 2.1 1 1 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EMC82893.1 - 0.017 15.4 2.4 0.037 14.3 2.4 1.8 1 1 0 1 1 1 0 Myb-like DNA-binding domain Pep_deformylase PF01327.21 EMC82893.1 - 0.053 13.1 0.0 0.062 12.9 0.0 1.1 1 0 0 1 1 1 0 Polypeptide deformylase Myb_DNA-bind_4 PF13837.6 EMC82894.1 - 5.4e-22 78.0 2.5 6.2e-22 77.8 2.5 1.1 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_3 PF12776.7 EMC82894.1 - 0.00026 21.9 2.2 0.00029 21.8 2.2 1.2 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.6 EMC82894.1 - 0.0011 19.0 3.1 0.0028 17.7 3.1 1.7 1 1 0 1 1 1 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.9 EMC82894.1 - 0.0012 19.1 0.9 0.0015 18.8 0.9 1.2 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_6 PF13921.6 EMC82894.1 - 0.0025 18.0 1.3 0.0042 17.3 1.3 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain FadA PF09403.10 EMC82894.1 - 0.027 14.9 0.6 0.037 14.5 0.6 1.3 1 0 0 1 1 1 0 Adhesion protein FadA Myb_DNA-bind_4 PF13837.6 EMC82895.1 - 5.7e-19 68.3 1.7 7.3e-19 68.0 1.7 1.1 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-binding PF00249.31 EMC82895.1 - 0.0015 18.7 1.8 0.0027 17.8 1.8 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EMC82895.1 - 0.012 15.8 1.6 0.038 14.2 1.6 1.8 1 1 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-bind_5 PF13873.6 EMC82895.1 - 0.023 14.7 3.8 0.13 12.4 3.8 2.0 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain Myb_DNA-bind_3 PF12776.7 EMC82895.1 - 0.1 13.6 1.1 0.16 13.0 1.1 1.3 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain SDP_N PF12278.8 EMC82895.1 - 0.11 12.6 0.0 0.13 12.4 0.0 1.1 1 0 0 1 1 1 0 Sex determination protein N terminal GATase_6 PF13522.6 EMC82896.1 - 5.6e-15 55.7 0.0 1.1e-14 54.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EMC82896.1 - 7.5e-13 48.5 0.0 1.3e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 EMC82896.1 - 1.9e-08 34.0 0.0 3.2e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 EMC82896.1 - 1.4e-06 27.5 0.0 2.1e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_2 PF00310.21 EMC82896.1 - 0.0058 15.4 0.0 0.0093 14.7 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II UPRTase PF14681.6 EMC82896.1 - 0.15 11.5 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase AMP-binding PF00501.28 EMC82897.1 - 5.6e-45 153.7 0.0 8.8e-45 153.0 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme PQQ_3 PF13570.6 EMC82897.1 - 6.4e-35 118.7 0.0 3.7e-06 27.2 0.2 9.2 9 0 0 9 9 9 6 PQQ-like domain PQQ_2 PF13360.6 EMC82897.1 - 1.4e-23 83.7 0.0 1.2e-09 38.1 0.0 3.2 2 1 2 4 4 4 3 PQQ-like domain PQQ PF01011.21 EMC82897.1 - 1.2e-21 75.5 8.0 0.0023 17.7 0.0 8.7 8 0 0 8 8 8 7 PQQ enzyme repeat AMP-binding_C PF13193.6 EMC82897.1 - 0.0019 19.1 0.0 0.0052 17.7 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain PP-binding PF00550.25 EMC82897.1 - 0.0028 18.0 0.0 0.0069 16.7 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site ANAPC4_WD40 PF12894.7 EMC82897.1 - 0.006 16.9 0.2 9.9 6.5 0.0 4.6 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Meleagrin PF08189.11 EMC82897.1 - 0.019 14.6 0.6 0.1 12.3 0.6 2.3 1 0 0 1 1 1 0 Meleagrin/Cygnin family DUF4592 PF15262.6 EMC82898.1 - 4.4e-37 127.7 1.5 4.4e-37 127.7 1.5 6.7 4 2 1 5 5 5 1 Domain of unknown function (DUF4592) KASH_CCD PF14662.6 EMC82899.1 - 0.00065 19.6 9.2 0.00065 19.6 9.2 9.4 2 1 5 8 8 8 4 Coiled-coil region of CCDC155 or KASH APG6_N PF17675.1 EMC82899.1 - 0.0068 16.9 5.7 0.0068 16.9 5.7 12.3 3 3 8 11 11 11 2 Apg6 coiled-coil region PilW PF16074.5 EMC82899.1 - 0.02 14.9 0.3 0.15 12.1 0.0 2.5 2 0 0 2 2 2 0 Type IV Pilus-assembly protein W ATG16 PF08614.11 EMC82899.1 - 0.08 13.2 171.2 0.089 13.0 21.9 10.1 3 2 7 10 10 10 0 Autophagy protein 16 (ATG16) PKcGMP_CC PF16808.5 EMC82899.1 - 0.19 11.6 0.1 0.19 11.6 0.1 15.5 18 0 0 18 18 18 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF1664 PF07889.12 EMC82899.1 - 0.33 11.0 102.3 0.037 14.1 1.0 12.6 6 4 6 13 13 13 0 Protein of unknown function (DUF1664) Golgin_A5 PF09787.9 EMC82899.1 - 9.5 5.6 165.1 0.19 11.1 23.1 8.6 2 1 5 8 8 8 0 Golgin subfamily A member 5 Sec3_C PF09763.9 EMC82900.1 - 1.6e-182 608.6 26.7 2e-182 608.3 26.7 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 EMC82900.1 - 2.7e-26 91.5 1.4 9.2e-26 89.8 1.4 2.0 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH FlaC_arch PF05377.11 EMC82900.1 - 0.058 13.8 5.2 0.27 11.7 2.3 3.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Csm2_III-A PF03750.13 EMC82900.1 - 0.46 11.3 7.1 0.15 12.9 1.3 3.1 2 1 0 2 2 2 0 Csm2 Type III-A TLV_coat PF00429.19 EMC82901.1 - 2.9e-05 23.0 2.3 3.6e-05 22.7 2.3 1.0 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) GP41 PF00517.17 EMC82901.1 - 0.0078 16.1 0.8 0.0095 15.9 0.8 1.1 1 0 0 1 1 1 1 Retroviral envelope protein Phlebovirus_G2 PF07245.11 EMC82901.1 - 0.018 13.6 0.6 0.017 13.6 0.6 1.1 1 0 0 1 1 1 0 Phlebovirus glycoprotein G2 NMU PF02070.15 EMC82902.1 - 4.9e-12 45.5 1.1 1.3e-11 44.1 1.1 1.8 1 0 0 1 1 1 1 Neuromedin U Phosducin PF02114.16 EMC82903.1 - 7.6e-18 64.4 0.2 1.7e-17 63.3 0.2 1.5 1 1 1 2 2 2 1 Phosducin Thioredoxin PF00085.20 EMC82903.1 - 0.023 14.7 0.0 0.041 13.9 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin HLH PF00010.26 EMC82904.1 - 9.6e-12 44.7 0.9 2.1e-11 43.6 0.9 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS PF00989.25 EMC82904.1 - 2.9e-08 33.7 0.1 2e-07 31.0 0.0 2.1 2 1 0 2 2 2 1 PAS fold PAS_9 PF13426.7 EMC82904.1 - 5.4e-05 23.4 0.1 0.00037 20.7 0.0 2.2 2 1 1 3 3 3 1 PAS domain PAS_11 PF14598.6 EMC82905.1 - 1.5e-20 73.4 0.0 1.5e-20 73.4 0.0 3.1 3 0 0 3 3 3 1 PAS domain PAS_3 PF08447.12 EMC82905.1 - 2.9e-16 59.5 0.6 8.8e-16 58.0 0.1 2.0 2 0 0 2 2 2 1 PAS fold ThiD2 PF17792.1 EMC82905.1 - 0.62 10.5 2.8 0.44 11.0 0.1 2.1 2 0 0 2 2 2 0 ThiD2 family UPF0016 PF01169.19 EMC82906.1 - 4.5e-45 151.9 19.7 4.7e-23 81.3 3.3 2.3 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 Steroid_dh PF02544.16 EMC82907.1 - 8.3e-24 84.3 7.0 1.5e-23 83.4 6.7 1.6 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase FB_lectin PF07367.11 EMC82907.1 - 0.028 14.3 0.1 0.047 13.6 0.1 1.3 1 0 0 1 1 1 0 Fungal fruit body lectin SPC25 PF06703.11 EMC82907.1 - 1.1 9.0 5.3 1.1 9.0 0.9 2.5 2 1 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Pkinase_Tyr PF07714.17 EMC82908.1 - 4.1e-105 350.7 0.0 6.5e-105 350.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.6 EMC82908.1 - 3.6e-58 194.1 14.5 4e-15 56.2 0.1 7.0 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.16 EMC82908.1 - 1.1e-52 176.0 6.4 1.6e-15 56.9 0.0 7.2 6 1 0 6 6 6 6 Immunoglobulin I-set domain Pkinase PF00069.25 EMC82908.1 - 5.2e-42 144.0 0.0 1e-29 103.7 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain ig PF00047.25 EMC82908.1 - 9e-37 125.1 15.7 1.7e-10 40.9 0.0 8.1 8 1 0 8 8 8 6 Immunoglobulin domain Ig_2 PF13895.6 EMC82908.1 - 8.6e-35 118.9 25.8 3.7e-10 40.0 0.0 8.7 8 2 0 8 8 7 5 Immunoglobulin domain VEGFR-2_TMD PF17988.1 EMC82908.1 - 3e-18 65.0 4.6 6e-18 64.0 4.6 1.6 1 0 0 1 1 1 1 VEGFR-2 Transmembrane domain V-set PF07686.17 EMC82908.1 - 2e-15 56.9 13.0 0.043 14.0 0.3 9.4 6 3 1 7 7 7 4 Immunoglobulin V-set domain Izumo-Ig PF16706.5 EMC82908.1 - 1.7e-08 34.4 7.7 2.6 8.2 0.0 6.9 6 1 0 6 6 6 2 Izumo-like Immunoglobulin domain C2-set_2 PF08205.12 EMC82908.1 - 6.9e-08 32.5 2.4 0.0023 18.0 0.0 4.5 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.5 EMC82908.1 - 9.3e-07 29.0 6.6 1.2 9.5 0.0 6.9 7 0 0 7 7 7 1 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 EMC82908.1 - 1.3e-06 27.9 1.2 23 4.6 0.0 5.7 5 0 0 5 5 5 0 Immunoglobulin domain Ig_5 PF16681.5 EMC82908.1 - 4.7e-06 26.9 3.5 17 5.9 0.0 6.7 6 1 0 6 6 6 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain HU-CCDC81_bac_1 PF18174.1 EMC82908.1 - 0.033 14.1 0.2 0.13 12.2 0.0 2.1 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 1 Haspin_kinase PF12330.8 EMC82908.1 - 0.072 12.0 1.2 0.078 11.9 0.1 1.5 2 0 0 2 2 2 0 Haspin like kinase domain Receptor_2B4 PF11465.8 EMC82908.1 - 0.13 12.5 2.4 15 5.8 0.0 4.6 5 1 1 6 6 6 0 Natural killer cell receptor 2B4 Pkinase_Tyr PF07714.17 EMC82909.1 - 4.5e-104 347.3 0.0 6.6e-104 346.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC82909.1 - 1.9e-42 145.5 0.0 2.6e-30 105.7 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.6 EMC82909.1 - 1.7e-30 105.5 7.2 2e-09 37.9 0.1 5.5 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 EMC82909.1 - 3.2e-24 84.8 3.8 2e-09 37.4 0.1 5.6 5 1 1 6 6 6 4 Immunoglobulin I-set domain ig PF00047.25 EMC82909.1 - 1.5e-16 60.3 12.9 2.3e-10 40.5 0.2 5.3 5 1 0 5 5 5 4 Immunoglobulin domain Ig_2 PF13895.6 EMC82909.1 - 2.3e-11 43.9 6.7 0.00013 22.2 0.1 5.0 5 0 0 5 5 5 3 Immunoglobulin domain V-set PF07686.17 EMC82909.1 - 5.9e-08 32.8 8.0 0.37 11.0 0.1 6.5 5 2 0 5 5 5 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC82909.1 - 8.8e-05 22.5 0.2 0.46 10.6 0.0 2.9 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 EMC82909.1 - 0.001 19.4 0.4 1.3 9.4 0.1 3.7 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 EMC82909.1 - 0.0011 18.5 0.6 0.55 9.8 0.0 3.5 3 0 0 3 3 3 1 Immunoglobulin domain APH PF01636.23 EMC82909.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Adeno_E3_CR1 PF02440.15 EMC82909.1 - 1.3 8.9 3.6 8.4 6.3 0.0 3.8 4 0 0 4 4 4 0 Adenovirus E3 region protein CR1 Adeno_E3 PF06040.11 EMC82909.1 - 3.2 7.9 8.3 16 5.7 6.4 2.5 2 0 0 2 2 2 0 Adenovirus E3 protein Pkinase_Tyr PF07714.17 EMC82910.1 - 5.2e-105 350.4 0.0 9.3e-105 349.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC82910.1 - 5.5e-42 144.0 0.0 1.4e-28 100.0 0.0 2.6 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.6 EMC82910.1 - 2.7e-24 85.5 9.4 7.8e-07 29.6 0.1 5.9 5 1 0 5 5 5 4 Immunoglobulin domain I-set PF07679.16 EMC82910.1 - 1.3e-20 73.2 7.1 5.3e-08 32.8 0.4 5.0 4 1 0 4 4 4 3 Immunoglobulin I-set domain ig PF00047.25 EMC82910.1 - 8e-18 64.4 12.4 0.00038 20.6 0.0 5.9 6 0 0 6 6 6 5 Immunoglobulin domain Ig_2 PF13895.6 EMC82910.1 - 2.4e-13 50.2 9.2 3.9e-05 23.9 0.1 5.9 5 2 0 5 5 5 3 Immunoglobulin domain V-set PF07686.17 EMC82910.1 - 6.5e-05 23.1 7.5 0.031 14.4 0.2 5.6 5 2 0 5 5 5 1 Immunoglobulin V-set domain Herpes_gE PF02480.16 EMC82910.1 - 0.00075 18.4 1.0 0.47 9.1 0.1 3.4 3 1 1 4 4 4 2 Alphaherpesvirus glycoprotein E Gypsy PF07253.11 EMC82910.1 - 0.013 14.0 0.1 1.9 6.9 0.0 2.3 2 0 0 2 2 2 0 Gypsy protein C2-set_2 PF08205.12 EMC82910.1 - 0.15 12.1 3.5 7.9 6.6 0.0 4.4 5 0 0 5 5 5 0 CD80-like C2-set immunoglobulin domain Adeno_E3_CR1 PF02440.15 EMC82910.1 - 0.63 9.9 3.5 3.1 7.7 0.3 3.1 3 1 0 3 3 3 0 Adenovirus E3 region protein CR1 Homeodomain PF00046.29 EMC82911.1 - 2.7e-22 78.3 4.6 6.3e-22 77.2 4.6 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC82911.1 - 0.027 14.3 1.0 0.097 12.6 0.3 2.1 2 0 0 2 2 2 0 Homeobox KN domain Terminase_5 PF06056.12 EMC82911.1 - 0.18 11.7 0.5 0.87 9.5 0.1 2.0 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) Erf4 PF10256.9 EMC82912.1 - 3.6e-10 40.0 0.0 4.6e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family PDZ PF00595.24 EMC82913.1 - 3.8e-61 203.4 3.3 5.7e-17 61.8 0.0 4.4 4 0 0 4 4 4 4 PDZ domain PDZ_6 PF17820.1 EMC82913.1 - 7.2e-31 105.8 0.7 1.6e-08 34.2 0.0 4.4 4 0 0 4 4 4 4 PDZ domain PDZ_2 PF13180.6 EMC82913.1 - 1.7e-16 60.3 0.0 0.0024 18.2 0.0 4.3 4 0 0 4 4 4 4 PDZ domain zf-RING_2 PF13639.6 EMC82913.1 - 3.6e-05 24.0 5.6 0.00014 22.1 5.6 2.1 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC82913.1 - 6.8e-05 22.6 8.4 0.00021 21.1 8.4 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC82913.1 - 7e-05 22.6 6.5 0.00019 21.2 6.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Tricorn_PDZ PF14685.6 EMC82913.1 - 0.00012 22.0 0.1 6 6.9 0.0 4.2 4 0 0 4 4 4 1 Tricorn protease PDZ domain zf-RING_UBOX PF13445.6 EMC82913.1 - 0.00014 21.8 7.4 0.00041 20.3 7.4 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMC82913.1 - 0.00045 20.1 4.5 0.0016 18.3 4.5 2.0 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EMC82913.1 - 0.001 19.2 7.6 0.0035 17.5 7.6 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EMC82913.1 - 0.0012 18.7 2.9 0.0012 18.7 2.9 2.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMC82913.1 - 0.0035 17.6 2.5 0.014 15.7 2.5 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain DZR PF12773.7 EMC82913.1 - 0.24 11.4 1.8 1.3 9.1 1.8 2.3 1 1 0 1 1 1 0 Double zinc ribbon Fip1 PF05182.13 EMC82914.1 - 5.1e-25 86.7 2.1 5.1e-25 86.7 2.1 1.8 2 0 0 2 2 2 1 Fip1 motif Ras PF00071.22 EMC82915.1 - 4.2e-18 65.5 0.0 5.6e-18 65.1 0.0 1.2 1 0 0 1 1 1 1 Ras family RsgA_GTPase PF03193.16 EMC82915.1 - 0.0064 16.4 0.1 0.032 14.1 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 EMC82915.1 - 0.018 15.1 0.0 0.036 14.1 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC82915.1 - 0.023 14.2 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain UCH PF00443.29 EMC82916.1 - 2.3e-60 204.2 5.8 2.7e-60 204.0 5.8 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMC82916.1 - 1.3e-28 100.6 11.7 2.5e-28 99.6 11.7 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 EMC82916.1 - 1.3e-05 24.8 14.3 5.8e-05 22.7 11.8 2.1 2 0 0 2 2 2 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase DUF3399 PF11879.8 EMC82916.1 - 0.48 10.8 7.8 1 9.7 7.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3399) MIEAP PF16026.5 EMC82917.1 - 1.9e-57 194.7 0.0 2.2e-57 194.5 0.0 1.0 1 0 0 1 1 1 1 Mitochondria-eating protein Sarcoglycan_1 PF04790.13 EMC82918.1 - 7.9e-64 215.5 0.1 9.3e-64 215.3 0.1 1.0 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein Sec62 PF03839.16 EMC82918.1 - 3.3 7.1 4.3 6.8 6.1 4.3 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 LRR_8 PF13855.6 EMC82919.1 - 7.8e-28 96.0 26.2 6.5e-13 48.2 0.5 5.0 3 1 2 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 EMC82919.1 - 3.5e-14 52.7 24.0 3.2e-06 27.4 5.4 5.1 4 1 2 6 6 6 4 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC82919.1 - 1.5e-07 31.4 0.3 4.5e-06 26.7 0.0 2.4 2 1 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EMC82919.1 - 3.6e-06 26.8 16.7 0.24 12.1 1.1 6.2 6 1 0 6 6 6 3 Leucine Rich Repeat LRR_9 PF14580.6 EMC82919.1 - 5.4e-05 22.8 5.1 0.08 12.4 0.2 2.5 2 1 1 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.6 EMC82919.1 - 0.00041 20.2 17.5 3.6 7.9 0.0 6.4 7 0 0 7 7 7 4 Leucine Rich repeat TAT_ubiq PF07706.12 EMC82919.1 - 0.24 11.6 0.4 0.94 9.7 0.1 1.9 2 0 0 2 2 2 0 Aminotransferase ubiquitination site Cullin_binding PF03556.15 EMC82920.1 - 2.2e-31 108.8 0.6 3.9e-31 108.0 0.6 1.4 1 0 0 1 1 1 1 Cullin binding DUF2621 PF11084.8 EMC82921.1 - 0.032 14.2 0.1 0.24 11.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2621) HCV_NS4a PF01006.20 EMC82921.1 - 0.9 9.3 5.6 0.77 9.6 0.0 2.7 2 0 0 2 2 2 0 Hepatitis C virus non-structural protein NS4a OCIA PF07051.11 EMC82922.1 - 1.8e-31 108.0 0.3 1.9e-31 107.9 0.3 1.0 1 0 0 1 1 1 1 Ovarian carcinoma immunoreactive antigen (OCIA) GLTT PF01744.20 EMC82922.1 - 0.034 13.9 0.1 0.066 13.0 0.1 1.5 1 0 0 1 1 1 0 GLTT repeat (6 copies) OCIA PF07051.11 EMC82923.1 - 4.9e-30 103.4 0.1 7.7e-30 102.8 0.1 1.3 1 0 0 1 1 1 1 Ovarian carcinoma immunoreactive antigen (OCIA) MOR2-PAG1_N PF14222.6 EMC82925.1 - 1.3e-174 582.2 4.7 2.2e-174 581.5 4.7 1.4 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 EMC82925.1 - 1.4e-74 251.1 5.0 1.4e-74 251.1 5.0 3.6 4 0 0 4 4 4 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 EMC82925.1 - 2.3e-35 121.6 15.5 3.3e-14 51.6 0.2 6.1 6 0 0 6 6 6 6 Cell morphogenesis central region SLAIN PF15301.6 EMC82926.1 - 2e-167 557.9 39.6 2.3e-167 557.7 39.6 1.0 1 0 0 1 1 1 1 SLAIN motif-containing family Pkinase_Tyr PF07714.17 EMC82927.1 - 1.1e-94 316.6 0.2 1.5e-94 316.1 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC82927.1 - 2e-46 158.5 0.0 2.9e-46 158.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH3_1 PF00018.28 EMC82927.1 - 2.4e-16 59.1 0.3 1.3e-15 56.7 0.2 2.3 3 0 0 3 3 3 1 SH3 domain PH PF00169.29 EMC82927.1 - 1.2e-15 57.9 1.0 1.1e-14 54.8 0.2 2.3 2 0 0 2 2 2 1 PH domain SH2 PF00017.24 EMC82927.1 - 1.3e-15 57.2 0.1 3.9e-15 55.7 0.1 1.8 1 0 0 1 1 1 1 SH2 domain BTK PF00779.19 EMC82927.1 - 1.4e-12 47.2 1.9 2.9e-12 46.2 1.9 1.6 1 0 0 1 1 1 1 BTK motif SH3_9 PF14604.6 EMC82927.1 - 6.1e-10 38.8 0.1 1.3e-09 37.8 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC82927.1 - 1.2e-07 31.3 0.1 2.9e-07 30.1 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 EMC82927.1 - 0.00086 19.5 1.9 0.012 15.9 1.0 2.5 2 0 0 2 2 2 1 Bacterial SH3 domain hSH3 PF14603.6 EMC82927.1 - 0.0039 17.6 0.1 0.013 15.9 0.1 2.0 1 0 0 1 1 1 1 Helically-extended SH3 domain SH3_10 PF17902.1 EMC82927.1 - 0.013 15.6 0.0 0.034 14.2 0.0 1.7 1 0 0 1 1 1 0 SH3 domain SH3_4 PF06347.13 EMC82927.1 - 0.055 13.3 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 Bacterial SH3 domain Kinase-like PF14531.6 EMC82927.1 - 0.069 12.5 0.0 0.18 11.1 0.0 1.6 1 0 0 1 1 1 0 Kinase-like Pkinase_Tyr PF07714.17 EMC82928.1 - 2.7e-96 321.8 0.1 3.5e-96 321.5 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC82928.1 - 3.1e-49 167.7 0.0 4.9e-49 167.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 EMC82928.1 - 5.9e-20 71.1 0.5 1.3e-19 70.1 0.5 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 EMC82928.1 - 3.8e-15 55.2 0.2 1.7e-14 53.1 0.1 2.2 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EMC82928.1 - 4.6e-07 29.6 0.0 1.1e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC82928.1 - 0.0034 17.0 0.0 0.01 15.5 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_10 PF17902.1 EMC82928.1 - 0.0055 16.7 0.0 0.014 15.4 0.0 1.7 1 0 0 1 1 1 1 SH3 domain Haspin_kinase PF12330.8 EMC82928.1 - 0.056 12.4 0.0 0.086 11.8 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 EMC82928.1 - 0.066 13.1 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Mg_trans_NIPA PF05653.14 EMC82929.1 - 6.3e-132 439.1 18.3 7.6e-132 438.9 18.3 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EMC82929.1 - 1.2e-08 35.2 5.3 1.2e-08 35.2 5.3 4.2 3 1 1 4 4 4 2 EamA-like transporter family DUF5392 PF17370.2 EMC82929.1 - 0.049 13.7 0.6 0.099 12.7 0.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5392) Deltameth_res PF16020.5 EMC82929.1 - 0.27 11.1 4.6 52 3.8 0.0 3.7 3 0 0 3 3 3 0 Deltamethrin resistance DoxX_3 PF13781.6 EMC82929.1 - 7 7.3 12.2 15 6.3 1.1 3.9 3 1 1 4 4 4 0 DoxX-like family Ion_trans PF00520.31 EMC82930.1 - 1.2e-33 116.4 11.7 1.8e-33 115.8 11.7 1.3 1 0 0 1 1 1 1 Ion transport protein CLZ PF16526.5 EMC82930.1 - 4.2e-27 94.3 5.6 4.2e-27 94.3 5.6 2.5 2 1 0 2 2 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels cNMP_binding PF00027.29 EMC82930.1 - 5.7e-19 68.0 0.0 9.4e-19 67.3 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Connexin PF00029.19 EMC82930.1 - 0.00018 21.3 2.0 0.00033 20.5 2.0 1.3 1 0 0 1 1 1 1 Connexin CSG2 PF16965.5 EMC82930.1 - 0.0045 16.0 0.1 0.0079 15.2 0.1 1.3 1 0 0 1 1 1 1 Ceramide synthase regulator Tim54 PF11711.8 EMC82930.1 - 0.0063 15.3 6.8 0.011 14.6 6.8 1.3 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 RNA_pol_Rpc4 PF05132.14 EMC82930.1 - 0.013 15.9 8.7 0.023 15.1 8.7 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 DDHD PF02862.17 EMC82930.1 - 0.015 15.5 0.0 0.023 14.8 0.0 1.4 1 0 0 1 1 1 0 DDHD domain Ion_trans_2 PF07885.16 EMC82930.1 - 0.015 15.2 4.1 0.054 13.5 4.1 2.0 1 0 0 1 1 1 0 Ion channel CDC45 PF02724.14 EMC82930.1 - 0.015 13.6 6.2 0.026 12.8 6.2 1.3 1 0 0 1 1 1 0 CDC45-like protein Afi1 PF07792.12 EMC82930.1 - 0.039 14.4 7.3 0.088 13.3 7.3 1.5 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Zip PF02535.22 EMC82930.1 - 0.043 13.0 0.0 0.065 12.4 0.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF913 PF06025.12 EMC82930.1 - 0.05 12.6 0.7 0.094 11.7 0.7 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SpoIIP PF07454.11 EMC82930.1 - 0.076 12.5 13.7 0.15 11.5 13.7 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) NPR3 PF03666.13 EMC82930.1 - 0.13 11.0 9.2 0.21 10.3 9.2 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Sec62 PF03839.16 EMC82930.1 - 0.15 11.6 16.7 0.057 12.9 12.4 2.2 2 0 0 2 2 2 0 Translocation protein Sec62 SlyX PF04102.12 EMC82930.1 - 0.15 12.7 2.2 0.4 11.3 1.1 2.2 2 0 0 2 2 2 0 SlyX OATP PF03137.20 EMC82930.1 - 0.16 10.2 1.3 0.27 9.4 1.3 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Presenilin PF01080.17 EMC82930.1 - 0.18 10.6 6.0 0.34 9.6 6.0 1.4 1 0 0 1 1 1 0 Presenilin Menin PF05053.13 EMC82930.1 - 0.38 9.1 5.6 0.64 8.3 5.6 1.2 1 0 0 1 1 1 0 Menin RNA_polI_A34 PF08208.11 EMC82930.1 - 0.59 10.2 27.3 1.1 9.2 27.3 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF3464 PF11947.8 EMC82930.1 - 0.6 9.9 8.3 1.4 8.7 8.3 1.6 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 V_ATPase_I PF01496.19 EMC82930.1 - 0.83 7.5 12.4 0.21 9.5 6.8 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Eapp_C PF10238.9 EMC82930.1 - 0.86 9.7 7.6 1.9 8.6 7.6 1.5 1 0 0 1 1 1 0 E2F-associated phosphoprotein CPSF100_C PF13299.6 EMC82930.1 - 1.1 9.4 11.7 2.5 8.3 11.7 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF2828 PF11443.8 EMC82930.1 - 1.5 6.8 10.7 3 5.8 10.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Rtf2 PF04641.12 EMC82930.1 - 1.5 8.1 18.1 3.3 7.0 18.1 1.5 1 0 0 1 1 1 0 Rtf2 RING-finger NARP1 PF12569.8 EMC82930.1 - 1.8 7.4 22.7 3.5 6.4 22.7 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Kei1 PF08552.11 EMC82930.1 - 3.6 7.4 6.8 0.42 10.5 1.2 2.1 1 1 1 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 zf-NF-X1 PF01422.17 EMC82931.1 - 5.6e-14 51.9 100.0 9.6e-06 25.6 14.3 17.9 19 0 0 19 19 19 10 NF-X1 type zinc finger Casc1_N PF15927.5 EMC82931.1 - 0.0099 15.6 4.9 0.025 14.3 4.9 1.7 1 0 0 1 1 1 1 Cancer susceptibility candidate 1 N-terminus Trypsin PF00089.26 EMC82932.1 - 5.1e-63 212.8 0.0 1.3e-62 211.6 0.0 1.7 1 0 0 1 1 1 1 Trypsin Ldl_recept_a PF00057.18 EMC82932.1 - 5.3e-60 199.3 148.9 1.1e-10 41.5 7.1 9.6 9 1 0 9 9 9 7 Low-density lipoprotein receptor domain class A Fz PF01392.22 EMC82932.1 - 1.4e-44 151.2 18.1 9.5e-26 90.6 5.9 5.4 5 0 0 5 5 5 2 Fz domain Trypsin_2 PF13365.6 EMC82932.1 - 3.2e-08 34.6 0.0 5.4e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain SRCR_2 PF15494.6 EMC82932.1 - 3.4e-08 33.9 1.6 3.4e-08 33.9 1.6 2.8 3 0 0 3 3 3 1 Scavenger receptor cysteine-rich domain PhoLip_ATPase_C PF16212.5 EMC82933.1 - 4.7e-78 262.4 28.3 4.7e-78 262.4 28.3 2.3 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EMC82933.1 - 1e-22 79.5 3.1 1e-22 79.5 3.1 2.1 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EMC82933.1 - 4.9e-12 46.6 0.0 4.4e-06 27.1 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EMC82933.1 - 2.4e-10 40.4 0.0 1.4e-09 37.9 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EMC82933.1 - 0.0027 17.5 3.6 0.007 16.1 0.4 2.9 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase 23S_rRNA_IVP PF05635.11 EMC82933.1 - 0.017 15.4 0.1 0.089 13.1 0.0 2.2 2 0 0 2 2 2 0 23S rRNA-intervening sequence protein COMM_domain PF07258.14 EMC82934.1 - 1.6e-16 60.1 1.2 3e-16 59.3 1.2 1.4 1 0 0 1 1 1 1 COMM domain HOIP-UBA PF16678.5 EMC82934.1 - 0.0032 17.5 0.2 0.0059 16.6 0.2 1.5 1 0 0 1 1 1 1 HOIP UBA domain pair FliG_C PF01706.16 EMC82934.1 - 0.097 12.9 2.0 0.19 11.9 0.9 2.0 1 1 1 2 2 2 0 FliG C-terminal domain Neur_chan_memb PF02932.16 EMC82935.1 - 1.3e-48 166.1 0.4 3.9e-48 164.6 0.4 1.7 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 EMC82935.1 - 2.5e-37 128.4 0.0 4e-37 127.8 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_LBD PF02931.23 EMC82936.1 - 5.4e-49 166.6 0.0 7.7e-49 166.0 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC82936.1 - 2.1e-42 145.8 0.5 3.3e-42 145.2 0.5 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF3695 PF12494.8 EMC82936.1 - 0.025 14.5 0.2 9.1 6.2 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3695) DUF4396 PF14342.6 EMC82936.1 - 0.24 11.8 7.5 1.1 9.6 2.3 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4396) Neur_chan_LBD PF02931.23 EMC82937.1 - 7.1e-50 169.4 0.0 1.1e-49 168.8 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC82937.1 - 5.7e-38 131.3 7.8 8.4e-31 107.9 5.6 2.3 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region CytochromB561_N PF09786.9 EMC82937.1 - 0.074 12.0 2.0 0.1 11.6 2.0 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal DUF5522 PF17653.1 EMC82937.1 - 0.12 12.4 0.1 0.34 10.9 0.1 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5522) Neur_chan_memb PF02932.16 EMC82938.1 - 1.1e-40 140.2 2.8 9.1e-36 124.1 0.7 2.1 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Glucosamine_iso PF01182.20 EMC82939.1 - 2.6e-20 73.3 0.0 3.7e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase GTP_EFTU PF00009.27 EMC82940.1 - 3.3e-53 180.1 0.3 4.9e-53 179.6 0.3 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 EMC82940.1 - 1.2e-47 160.5 0.5 6.9e-47 158.0 0.7 2.2 2 0 0 2 2 2 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 EMC82940.1 - 9.2e-21 73.7 0.0 3.7e-20 71.8 0.0 2.1 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EMC82940.1 - 6.1e-08 32.9 0.3 1.5e-07 31.7 0.3 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Ras PF00071.22 EMC82940.1 - 3.9e-07 29.8 0.1 6.6e-07 29.1 0.1 1.3 1 0 0 1 1 1 1 Ras family RF3_C PF16658.5 EMC82940.1 - 6.8e-06 25.9 0.0 1.4e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 EMC82940.1 - 7.4e-06 26.0 0.1 1.4e-05 25.1 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 EMC82940.1 - 1.9e-05 24.7 0.0 6.9e-05 22.9 0.0 2.0 1 1 0 1 1 1 1 Elongation Factor G, domain II SRPRB PF09439.10 EMC82940.1 - 0.0017 17.8 0.0 0.0045 16.4 0.0 1.8 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.5 EMC82940.1 - 0.0036 17.3 0.1 0.0099 15.9 0.1 1.8 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain Septin PF00735.18 EMC82940.1 - 0.015 14.6 0.8 0.15 11.3 0.0 2.2 2 0 0 2 2 2 0 Septin FeoB_N PF02421.18 EMC82940.1 - 0.028 13.9 0.4 0.088 12.3 0.4 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B Beta_protein PF14350.6 EMC82940.1 - 0.09 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Beta protein BTB_2 PF02214.22 EMC82941.1 - 6.3e-16 58.5 0.0 1.3e-15 57.5 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 EMC82941.1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 BTB/POZ domain Glutaredoxin PF00462.24 EMC82942.1 - 6.1e-11 42.4 0.1 6.3e-09 35.9 0.2 2.3 2 0 0 2 2 2 2 Glutaredoxin PhoLip_ATPase_C PF16212.5 EMC82943.1 - 1.3e-84 283.9 19.2 1.3e-84 283.9 19.2 2.4 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EMC82943.1 - 7.9e-26 89.5 4.3 2.4e-25 88.0 4.3 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EMC82943.1 - 4.1e-13 49.2 0.0 4.6e-12 45.9 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EMC82943.1 - 1.3e-12 48.5 0.0 2.4e-05 24.7 0.0 3.4 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EMC82943.1 - 6.1e-11 42.2 0.0 2.7e-10 40.1 0.0 2.1 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EMC82943.1 - 0.00018 21.3 0.3 0.012 15.3 0.1 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Shisa PF13908.6 EMC82944.1 - 9.8e-22 78.1 0.8 1.1e-21 77.9 0.8 1.2 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator BEN PF10523.9 EMC82945.1 - 2.3e-15 56.6 0.0 4.9e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 BEN domain bZIP_1 PF00170.21 EMC82945.1 - 0.0048 17.0 0.2 0.013 15.5 0.2 1.8 1 0 0 1 1 1 1 bZIP transcription factor Uds1 PF15456.6 EMC82945.1 - 0.015 15.5 0.0 0.029 14.6 0.0 1.4 1 0 0 1 1 1 0 Up-regulated During Septation Cep57_CLD_2 PF14197.6 EMC82945.1 - 0.026 14.6 0.6 0.16 12.1 0.2 2.1 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Shugoshin_N PF07558.11 EMC82945.1 - 0.027 14.4 1.6 0.027 14.4 1.6 1.9 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region NYD-SP28_assoc PF14775.6 EMC82945.1 - 0.043 13.9 1.9 0.12 12.5 1.9 1.8 1 0 0 1 1 1 0 Sperm tail C-terminal domain bZIP_2 PF07716.15 EMC82945.1 - 0.043 13.9 3.9 0.097 12.8 3.9 1.5 1 0 0 1 1 1 0 Basic region leucine zipper Herpes_BLRF2 PF05812.12 EMC82945.1 - 0.1 12.8 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein Cation_efflux PF01545.21 EMC82946.1 - 3e-30 105.4 7.8 3.8e-30 105.1 7.8 1.1 1 0 0 1 1 1 1 Cation efflux family XPA_C PF05181.12 EMC82946.1 - 0.00016 21.6 0.0 0.00037 20.4 0.0 1.7 1 0 0 1 1 1 1 XPA protein C-terminus ZT_dimer PF16916.5 EMC82946.1 - 0.0028 17.7 1.1 0.099 12.8 0.1 3.0 2 1 1 3 3 3 1 Dimerisation domain of Zinc Transporter Ion_trans_N PF08412.10 EMC82946.1 - 0.033 13.8 0.0 0.078 12.6 0.0 1.6 1 0 0 1 1 1 0 Ion transport protein N-terminal Peptidase_M30 PF10460.9 EMC82946.1 - 0.041 12.8 0.1 0.15 11.0 0.0 1.7 2 0 0 2 2 2 0 Peptidase M30 P2 PF07194.11 EMC82946.1 - 0.073 13.1 0.1 0.3 11.2 0.2 2.0 2 0 0 2 2 2 0 P2 response regulator binding domain Deltameth_res PF16020.5 EMC82946.1 - 0.16 11.9 0.4 0.59 10.0 0.0 2.2 2 0 0 2 2 2 0 Deltamethrin resistance UPF0121 PF03661.13 EMC82947.1 - 9.8e-94 313.3 17.9 1.1e-93 313.1 17.9 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) Caldesmon PF02029.15 EMC82948.1 - 2.9e-08 32.9 52.0 4.3e-08 32.4 52.0 1.3 1 0 0 1 1 1 1 Caldesmon BUD22 PF09073.10 EMC82948.1 - 0.00023 20.6 69.7 0.00034 20.1 69.7 1.2 1 0 0 1 1 1 1 BUD22 AF-4 PF05110.13 EMC82948.1 - 0.0014 16.8 24.2 0.0015 16.7 24.2 1.1 1 0 0 1 1 1 1 AF-4 proto-oncoprotein Nop14 PF04147.12 EMC82948.1 - 0.016 13.4 72.2 0.023 12.9 72.2 1.2 1 0 0 1 1 1 0 Nop14-like family GREB1 PF15782.5 EMC82948.1 - 1.9 5.5 12.7 2.5 5.1 12.7 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4045 PF13254.6 EMC82948.1 - 5.9 6.4 40.9 9.5 5.7 40.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Homeodomain PF00046.29 EMC82949.1 - 6e-14 51.6 0.5 1e-13 50.9 0.5 1.3 1 0 0 1 1 1 1 Homeodomain Myb_DNA-bind_3 PF12776.7 EMC82949.1 - 0.022 15.7 0.0 1.6 9.8 0.0 2.1 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain DUF4757 PF15949.5 EMC82950.1 - 7.9e-65 218.5 10.2 7.9e-65 218.5 10.2 3.8 2 1 1 3 3 3 1 Domain of unknown function (DUF4757) LIM PF00412.22 EMC82950.1 - 1.8e-07 31.3 0.3 4.3e-07 30.1 0.3 1.7 1 0 0 1 1 1 1 LIM domain Peptidase_C12 PF01088.21 EMC82951.1 - 3.5e-56 190.3 0.1 4e-56 190.1 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 PID PF00640.23 EMC82952.1 - 2.9e-47 160.2 0.1 5.9e-34 117.1 0.0 2.4 2 0 0 2 2 2 2 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 EMC82952.1 - 7.2e-07 29.4 0.0 0.00086 19.5 0.0 2.5 2 0 0 2 2 2 2 Phosphotyrosine-binding domain WW PF00397.26 EMC82952.1 - 7.6e-07 29.1 2.0 1.9e-06 27.9 2.0 1.7 1 0 0 1 1 1 1 WW domain DUF2156 PF09924.9 EMC82952.1 - 0.16 11.0 0.0 0.24 10.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2156) Methyltr_RsmB-F PF01189.17 EMC82953.1 - 1.8e-08 34.2 0.4 1.4e-07 31.4 0.2 2.3 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Neur_chan_LBD PF02931.23 EMC82954.1 - 6.2e-68 228.5 1.9 8.1e-68 228.1 1.9 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC82954.1 - 7.7e-48 163.6 0.1 1.1e-47 163.1 0.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Ras PF00071.22 EMC82956.1 - 9e-45 152.2 0.0 1.1e-44 151.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC82956.1 - 2.3e-22 79.4 0.0 3.4e-22 78.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC82956.1 - 1e-06 28.3 0.0 1.3e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC82956.1 - 0.021 14.9 0.0 0.037 14.1 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase TniB PF05621.11 EMC82956.1 - 0.063 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein SRPRB PF09439.10 EMC82956.1 - 0.15 11.5 0.0 0.46 9.9 0.0 1.7 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EMC82956.1 - 0.16 11.9 0.0 0.54 10.1 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase Cnd1 PF12717.7 EMC82957.1 - 0.0068 16.5 9.3 1.1 9.3 0.0 5.8 4 2 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EMC82957.1 - 0.025 14.8 1.6 6.5 7.3 0.0 5.2 5 0 0 5 5 5 0 HEAT repeat HEAT_EZ PF13513.6 EMC82957.1 - 0.82 10.2 4.1 40 4.8 0.0 4.8 5 0 0 5 5 5 0 HEAT-like repeat UQ_con PF00179.26 EMC82958.1 - 2.4e-41 140.7 0.0 3.1e-41 140.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA PF00627.31 EMC82958.1 - 4.3e-11 42.5 0.0 9.5e-11 41.4 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain Prok-E2_B PF14461.6 EMC82958.1 - 3.1e-06 26.9 0.0 4.4e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EMC82958.1 - 0.0021 18.3 0.0 0.0033 17.7 0.0 1.3 1 0 0 1 1 1 1 RWD domain UBA_3 PF09288.10 EMC82958.1 - 0.095 12.5 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain DUF2615 PF11027.8 EMC82959.1 - 5.1e-41 139.1 0.0 6.1e-41 138.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2615) UDPG_MGDP_dh_N PF03721.14 EMC82960.1 - 2.2e-62 210.0 0.0 3.3e-62 209.4 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 EMC82960.1 - 2.1e-33 114.4 0.0 5.1e-33 113.1 0.0 1.7 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 EMC82960.1 - 1e-26 93.4 0.0 3.8e-25 88.3 0.0 2.6 3 0 0 3 3 3 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 3HCDH_N PF02737.18 EMC82960.1 - 0.0015 18.5 0.0 0.14 12.0 0.0 2.5 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ldh_1_N PF00056.23 EMC82960.1 - 0.0078 16.3 0.0 3.6 7.7 0.0 3.8 2 2 2 4 4 4 1 lactate/malate dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EMC82960.1 - 0.026 14.8 0.0 0.057 13.7 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_2 PF03446.15 EMC82960.1 - 0.056 13.6 0.0 0.16 12.1 0.0 1.9 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 EMC82960.1 - 0.1 12.2 0.0 0.54 9.9 0.0 2.0 1 1 1 2 2 2 0 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 EMC82960.1 - 0.12 13.0 0.0 3.7 8.2 0.0 3.2 4 2 0 4 4 4 0 NADP oxidoreductase coenzyme F420-dependent LIAS_N PF16881.5 EMC82961.1 - 3.1e-41 140.2 0.2 5.7e-41 139.3 0.2 1.5 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 EMC82961.1 - 1.1e-17 65.0 0.0 1.5e-17 64.5 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily Ribosomal_L6 PF00347.23 EMC82962.1 - 1.8e-33 115.0 1.1 1.7e-16 60.6 0.3 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 Glyco_hydro_1 PF00232.18 EMC82963.1 - 3.6e-210 698.1 18.0 4.1e-100 335.3 2.5 3.1 2 1 1 3 3 3 3 Glycosyl hydrolase family 1 Self-incomp_S1 PF05938.11 EMC82963.1 - 0.095 13.3 0.0 0.48 11.0 0.0 2.3 1 0 0 1 1 1 0 Plant self-incompatibility protein S1 WD40_3 PF15911.5 EMC82964.1 - 1.1e-28 99.0 2.0 4e-28 97.2 0.1 3.0 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC82964.1 - 9.4e-12 45.1 1.4 0.038 14.3 0.0 5.5 3 2 2 5 5 4 2 Anaphase-promoting complex subunit 4 WD40 domain Clathrin PF00637.20 EMC82964.1 - 4.2e-11 42.9 7.0 0.0015 18.4 0.1 5.1 3 1 1 5 5 5 3 Region in Clathrin and VPS Coatomer_WDAD PF04053.14 EMC82964.1 - 2e-08 33.8 2.3 0.059 12.4 0.0 3.9 4 1 0 4 4 4 3 Coatomer WD associated region WD40 PF00400.32 EMC82964.1 - 8.5e-06 26.4 6.8 6.3 7.9 0.0 6.5 6 0 0 6 6 6 2 WD domain, G-beta repeat TPR_8 PF13181.6 EMC82964.1 - 0.00018 21.5 7.2 1.1 9.6 0.1 6.2 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 EMC82964.1 - 0.00043 20.7 7.0 3.5 8.2 0.2 5.5 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMC82964.1 - 0.0017 18.6 11.8 7.4 6.9 0.3 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat eIF2A PF08662.11 EMC82964.1 - 0.0021 18.0 0.0 0.01 15.7 0.0 2.2 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A TPR_14 PF13428.6 EMC82964.1 - 0.0043 17.8 11.2 1.6 9.7 0.2 7.0 7 1 0 7 7 7 1 Tetratricopeptide repeat IKI3 PF04762.12 EMC82964.1 - 0.0051 14.9 0.2 0.61 8.0 0.0 3.0 3 0 0 3 3 3 1 IKI3 family TPR_7 PF13176.6 EMC82964.1 - 0.0092 15.9 9.8 6.5 7.0 0.2 6.0 6 1 0 6 6 5 1 Tetratricopeptide repeat Mcl1_mid PF12341.8 EMC82964.1 - 0.086 12.2 0.0 0.42 9.9 0.0 2.0 1 1 1 2 2 2 0 Minichromosome loss protein, Mcl1, middle region DZR PF12773.7 EMC82964.1 - 0.11 12.6 10.6 0.75 9.9 10.1 2.4 1 1 1 2 2 2 0 Double zinc ribbon SNAP PF14938.6 EMC82964.1 - 0.11 11.9 11.3 0.1 12.0 4.2 2.8 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP PD40 PF07676.12 EMC82964.1 - 0.15 12.0 1.1 81 3.3 0.0 3.5 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat ANAPC3 PF12895.7 EMC82964.1 - 0.16 12.2 13.2 0.53 10.6 0.8 5.2 4 1 0 5 5 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 EMC82964.1 - 0.21 11.8 21.5 1.8 8.9 0.3 6.8 7 0 0 7 7 5 0 Tetratricopeptide repeat zf-ribbon_3 PF13248.6 EMC82964.1 - 1.5 8.3 15.2 0.58 9.7 0.1 3.4 3 0 0 3 3 3 0 zinc-ribbon domain TPR_1 PF00515.28 EMC82964.1 - 2.6 8.0 19.8 10 6.1 0.9 6.5 7 0 0 7 7 7 0 Tetratricopeptide repeat Kelch_1 PF01344.25 EMC82965.1 - 5.7e-85 278.7 14.1 3.3e-18 65.0 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EMC82965.1 - 1.7e-52 174.1 5.4 1.4e-10 41.1 0.0 6.3 2 2 4 6 6 6 6 Kelch motif Kelch_2 PF07646.15 EMC82965.1 - 1.8e-34 116.4 6.8 2.1e-07 30.6 0.0 6.5 6 0 0 6 6 6 5 Kelch motif BACK PF07707.15 EMC82965.1 - 4.5e-33 113.4 1.3 1.1e-32 112.2 0.1 2.1 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 EMC82965.1 - 1.1e-29 102.9 0.2 1.9e-29 102.1 0.2 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_4 PF13418.6 EMC82965.1 - 1.9e-29 101.4 6.7 5.4e-07 29.5 0.0 6.2 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.6 EMC82965.1 - 6.2e-20 71.0 10.6 4.5e-08 33.2 0.1 6.2 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC82965.1 - 2.9e-08 33.5 4.3 0.076 13.0 0.0 5.6 7 0 0 7 7 7 2 Kelch motif Glu_cyclase_2 PF05096.12 EMC82965.1 - 0.00087 18.8 0.0 0.18 11.2 0.0 2.8 1 1 1 3 3 3 1 Glutamine cyclotransferase PQQ_3 PF13570.6 EMC82965.1 - 0.5 10.9 9.6 18 6.0 0.0 4.6 5 0 0 5 5 5 0 PQQ-like domain Pet191_N PF10203.9 EMC82965.1 - 0.96 9.8 6.9 4.3 7.7 1.9 2.9 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein PET191 TMEM156 PF15106.6 EMC82966.1 - 1.4e-78 263.4 8.7 1.7e-78 263.2 8.7 1.0 1 0 0 1 1 1 1 TMEM156 protein family Zip PF02535.22 EMC82966.1 - 0.38 9.9 1.3 1.2 8.2 0.2 1.9 2 0 0 2 2 2 0 ZIP Zinc transporter DUF719 PF05334.13 EMC82967.1 - 6.8e-65 218.8 2.0 6.8e-65 218.8 2.0 3.0 3 1 0 3 3 3 1 Protein of unknown function (DUF719) TetR_C_24 PF17932.1 EMC82967.1 - 0.025 14.9 0.1 0.083 13.2 0.1 1.9 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DUF2732 PF10809.8 EMC82967.1 - 1.1 9.2 4.5 6.8 6.6 4.5 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2732) TIR PF01582.20 EMC82968.1 - 5.4e-24 85.0 0.1 9.7e-24 84.1 0.1 1.3 1 0 0 1 1 1 1 TIR domain LRR_8 PF13855.6 EMC82968.1 - 1.7e-15 56.5 13.0 6.6e-08 32.2 3.1 4.4 3 2 2 5 5 5 4 Leucine rich repeat TIR_2 PF13676.6 EMC82968.1 - 1.4e-14 54.7 0.1 4.7e-14 53.0 0.1 1.9 1 0 0 1 1 1 1 TIR domain LRR_4 PF12799.7 EMC82968.1 - 6.7e-10 39.1 26.8 0.00021 21.6 2.1 6.4 3 3 4 7 7 7 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EMC82968.1 - 3.9e-06 26.5 11.9 0.52 10.5 0.2 6.3 6 0 0 6 6 6 2 Leucine Rich repeat LRRCT PF01463.24 EMC82968.1 - 6.3e-05 23.2 0.1 0.00025 21.4 0.1 2.1 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain LRR_9 PF14580.6 EMC82968.1 - 0.00076 19.0 1.2 0.17 11.4 0.2 2.4 2 0 0 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 EMC82968.1 - 0.0095 16.3 8.5 47 5.1 0.0 6.0 3 1 0 3 3 3 0 Leucine Rich Repeat LRR_8 PF13855.6 EMC82969.1 - 4e-29 100.1 32.6 2.9e-11 43.0 8.3 7.0 5 3 2 7 7 7 6 Leucine rich repeat TIR PF01582.20 EMC82969.1 - 9.6e-24 84.1 0.2 2e-23 83.1 0.2 1.5 1 0 0 1 1 1 1 TIR domain LRR_4 PF12799.7 EMC82969.1 - 2e-20 72.5 45.1 5.7e-05 23.4 3.9 8.4 6 2 2 8 8 8 6 Leucine Rich repeats (2 copies) TIR_2 PF13676.6 EMC82969.1 - 1.4e-14 54.7 0.1 6.3e-14 52.6 0.1 2.2 2 0 0 2 2 2 1 TIR domain LRR_6 PF13516.6 EMC82969.1 - 3.2e-10 39.2 35.2 0.64 10.2 0.2 11.3 12 0 0 12 12 12 4 Leucine Rich repeat LRRCT PF01463.24 EMC82969.1 - 7.7e-05 22.9 0.1 0.00031 21.1 0.1 2.2 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain LRR_9 PF14580.6 EMC82969.1 - 0.00048 19.7 11.6 0.23 11.0 0.2 3.7 3 1 0 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 EMC82969.1 - 0.0023 18.2 34.6 21 6.2 0.1 10.6 9 1 1 10 10 10 1 Leucine Rich Repeat zf-C2H2 PF00096.26 EMC82970.1 - 2.6e-16 59.1 22.9 2e-06 27.9 2.7 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC82970.1 - 1e-12 47.9 8.7 3.2e-09 36.8 1.0 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC82970.1 - 1.5e-08 34.7 20.1 0.0022 18.7 1.8 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 EMC82970.1 - 0.042 14.2 2.7 7.5 7.1 0.4 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMC82970.1 - 0.12 12.7 3.7 8.4 6.8 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMC82970.1 - 0.12 12.4 9.4 0.38 10.8 0.6 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 EMC82970.1 - 0.6 10.2 4.1 2.3 8.4 2.0 2.1 1 1 2 3 3 3 0 Aberrant zinc-finger FOXP-CC PF16159.5 EMC82970.1 - 1.4 9.6 8.1 4.6 8.0 0.7 3.1 2 1 1 3 3 3 0 FOXP coiled-coil domain RabGAP-TBC PF00566.18 EMC82971.1 - 4e-54 183.5 0.7 1.5e-53 181.6 0.7 2.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF3350 PF11830.8 EMC82971.1 - 3.7e-22 78.4 1.8 3.7e-22 78.4 1.8 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3350) PID PF00640.23 EMC82971.1 - 1.5e-08 34.8 0.9 3.8e-08 33.5 0.9 1.6 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) BET PF17035.5 EMC82971.1 - 0.073 13.3 1.6 17 5.7 0.1 3.0 2 0 0 2 2 2 0 Bromodomain extra-terminal - transcription regulation RnlB_antitoxin PF15933.5 EMC82971.1 - 0.079 13.3 2.1 0.25 11.7 2.1 1.9 1 0 0 1 1 1 0 Antitoxin to bacterial toxin RNase LS or RnlA FANCI_S1-cap PF14674.6 EMC82971.1 - 5.8 7.1 6.1 7.9 6.7 0.2 3.0 2 0 0 2 2 2 0 FANCI solenoid 1 cap PGM_PMM_I PF02878.16 EMC82972.1 - 1.6e-36 125.0 0.0 3.1e-36 124.1 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 EMC82972.1 - 2.2e-24 86.0 0.0 7e-24 84.4 0.0 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EMC82972.1 - 2.8e-12 46.8 0.2 1.2e-11 44.8 0.0 2.2 3 0 0 3 3 3 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 EMC82972.1 - 8.7e-06 25.8 0.0 2.6e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain RELT PF12606.8 EMC82973.1 - 9.3e-26 88.6 0.4 1.5e-25 87.8 0.4 1.4 1 0 0 1 1 1 1 Tumour necrosis factor receptor superfamily member 19 DUF4699 PF15770.5 EMC82974.1 - 2e-94 316.8 18.2 2.3e-94 316.7 18.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4699) ANAPC4_WD40 PF12894.7 EMC82975.1 - 1.2e-06 28.7 5.4 12 6.3 0.0 7.1 4 3 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EMC82975.1 - 0.0083 15.7 0.0 0.46 10.0 0.0 3.0 2 1 0 2 2 2 1 PQQ-like domain BBS2_Mid PF14783.6 EMC82975.1 - 0.042 13.9 0.3 8.3 6.5 0.0 4.1 3 1 1 4 4 4 0 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.32 EMC82975.1 - 0.053 14.4 2.0 14 6.8 0.2 5.7 7 0 0 7 7 7 0 WD domain, G-beta repeat STN1_2 PF09170.10 EMC82976.1 - 0.011 15.9 0.8 0.029 14.6 0.2 1.8 2 0 0 2 2 2 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 Bac_DnaA PF00308.18 EMC82976.1 - 0.016 15.0 0.2 0.054 13.3 0.0 2.0 2 0 0 2 2 2 0 Bacterial dnaA protein DUF3440 PF11922.8 EMC82976.1 - 0.025 14.3 0.7 0.045 13.4 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3440) AAA_28 PF13521.6 EMC82976.1 - 0.029 14.6 0.1 0.071 13.3 0.1 1.6 1 0 0 1 1 1 0 AAA domain ESM4 PF15952.5 EMC82976.1 - 0.064 13.7 1.1 0.2 12.0 0.9 1.8 2 0 0 2 2 2 0 Enhancer of split M4 family TipAS PF07739.13 EMC82976.1 - 0.067 13.7 1.2 0.22 12.1 0.4 2.1 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain AAA PF00004.29 EMC82976.1 - 0.092 13.2 1.6 0.12 12.8 0.2 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Death PF00531.22 EMC82977.1 - 9e-06 25.8 1.2 1.8e-05 24.8 1.2 1.5 1 0 0 1 1 1 1 Death domain ZU5 PF00791.20 EMC82977.1 - 0.028 14.7 0.2 0.55 10.6 0.0 2.6 3 0 0 3 3 3 0 ZU5 domain PH PF00169.29 EMC82978.1 - 5.3e-46 155.5 17.7 4.3e-11 43.3 0.3 5.8 5 0 0 5 5 5 5 PH domain RhoGAP PF00620.27 EMC82978.1 - 4.2e-40 137.1 0.2 1.4e-39 135.4 0.1 2.0 2 0 0 2 2 2 1 RhoGAP domain ArfGap PF01412.18 EMC82978.1 - 4.9e-33 113.7 2.9 8.5e-33 112.9 0.1 3.0 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf PH_6 PF15406.6 EMC82978.1 - 9.8e-11 41.9 0.2 2.5e-05 24.5 0.0 3.7 3 0 0 3 3 3 2 Pleckstrin homology domain SAM_2 PF07647.17 EMC82978.1 - 1.3e-09 38.0 0.0 6.3e-09 35.8 0.0 2.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EMC82978.1 - 3.7e-08 33.7 0.0 9.8e-08 32.3 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_8 PF15409.6 EMC82978.1 - 6.1e-08 32.8 7.1 0.35 11.2 0.2 5.5 5 0 0 5 5 5 3 Pleckstrin homology domain PH_11 PF15413.6 EMC82978.1 - 1.7e-07 31.6 16.1 1 9.8 1.0 7.3 5 2 0 5 5 5 3 Pleckstrin homology domain PH_3 PF14593.6 EMC82978.1 - 3e-05 24.1 6.8 0.017 15.2 0.1 4.0 4 0 0 4 4 4 2 PH domain RA PF00788.23 EMC82978.1 - 0.00018 22.1 0.0 0.0011 19.5 0.0 2.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PH_13 PF16652.5 EMC82978.1 - 0.0019 18.1 0.9 1.3 8.8 0.1 3.0 3 0 0 3 3 3 2 Pleckstrin homology domain PH_2 PF08458.10 EMC82978.1 - 0.0054 17.1 0.4 5.5 7.4 0.1 2.8 2 0 0 2 2 2 2 Plant pleckstrin homology-like region Mcp5_PH PF12814.7 EMC82978.1 - 0.0058 16.7 0.5 1.8 8.7 0.1 3.4 3 0 0 3 3 3 1 Meiotic cell cortex C-terminal pleckstrin homology Methyltransf_10 PF05971.12 EMC82978.1 - 0.088 12.1 0.0 0.2 11.0 0.0 1.5 1 0 0 1 1 1 0 RNA methyltransferase Nup188_C PF18378.1 EMC82978.1 - 0.13 11.1 0.7 0.53 9.0 0.0 2.1 2 0 0 2 2 2 0 Nuclear pore protein NUP188 C-terminal domain PH_4 PF15404.6 EMC82978.1 - 0.48 10.2 4.1 6.2 6.6 0.0 3.8 4 0 0 4 4 4 0 Pleckstrin homology domain Carm_PH PF17888.1 EMC82978.1 - 0.62 10.5 2.5 7.7 6.9 0.1 3.2 3 0 0 3 3 3 0 Carmil pleckstrin homology domain RVT_1 PF00078.27 EMC82980.1 - 0.028 13.9 0.0 0.081 12.4 0.0 1.7 1 1 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) SOAR PF16533.5 EMC82981.1 - 1.2e-40 137.5 3.9 1.2e-40 137.5 3.9 3.0 2 1 1 3 3 3 1 STIM1 Orai1-activating region SAM_2 PF07647.17 EMC82981.1 - 3e-12 46.5 0.1 8.3e-12 45.0 0.1 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EMC82981.1 - 3.9e-07 30.4 0.1 1.2e-06 28.8 0.1 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) DUF4446 PF14584.6 EMC82981.1 - 0.37 10.8 4.9 0.088 12.8 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) ESSS PF10183.9 EMC82981.1 - 0.4 10.9 0.0 0.4 10.9 0.0 3.0 3 0 0 3 3 3 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Orbi_NS3 PF01616.16 EMC82981.1 - 1.7 8.3 4.7 2.1 8.0 0.1 2.6 3 0 0 3 3 3 0 Orbivirus NS3 RabGAP-TBC PF00566.18 EMC82982.1 - 1.6e-14 54.1 6.9 3.7e-12 46.4 2.6 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain 7tm_1 PF00001.21 EMC82983.1 - 1.1e-62 211.7 17.6 1.7e-62 211.1 17.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CholecysA-Rec_N PF09193.10 EMC82983.1 - 2.5e-30 104.2 0.3 6.7e-30 102.9 0.3 1.8 1 0 0 1 1 1 1 Cholecystokinin A receptor, N-terminal 7tm_4 PF13853.6 EMC82983.1 - 2.8e-10 40.4 11.8 2.8e-10 40.4 11.8 1.8 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC82983.1 - 1.3e-08 34.8 18.3 1.3e-08 34.8 18.3 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 EMC82983.1 - 7.4e-08 32.1 23.8 5.9e-07 29.1 23.8 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF3671 PF12420.8 EMC82983.1 - 1.7 8.8 18.3 2.1 8.4 3.9 4.0 2 1 2 4 4 4 0 Protein of unknown function Brr6_like_C_C PF10104.9 EMC82983.1 - 2.8 7.7 9.7 0.38 10.5 2.2 3.0 2 2 0 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain BTD PF09270.10 EMC82984.1 - 1.4e-75 252.7 0.0 2.2e-75 252.0 0.0 1.3 1 0 0 1 1 1 1 Beta-trefoil DNA-binding domain LAG1-DNAbind PF09271.11 EMC82984.1 - 2.5e-50 171.0 0.7 5.9e-50 169.8 0.7 1.7 1 0 0 1 1 1 1 LAG1, DNA binding TIG PF01833.24 EMC82984.1 - 2.9e-05 24.0 0.9 0.00042 20.4 0.0 2.6 2 0 0 2 2 2 1 IPT/TIG domain RHD_dimer PF16179.5 EMC82984.1 - 0.017 15.1 0.0 0.071 13.1 0.0 2.2 1 1 0 1 1 1 0 Rel homology dimerisation domain Sel1 PF08238.12 EMC82985.1 - 2.5e-21 75.6 32.0 0.00013 22.5 0.1 8.6 8 0 0 8 8 8 6 Sel1 repeat Na_Pi_cotrans PF02690.15 EMC82986.1 - 2.8e-40 137.7 19.9 1.2e-24 87.0 6.7 2.7 2 0 0 2 2 2 2 Na+/Pi-cotransporter DUF2244 PF10003.9 EMC82986.1 - 9 6.0 7.0 35 4.1 7.0 2.0 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) zf-CCHC PF00098.23 EMC82987.1 - 0.0085 16.1 1.6 0.0085 16.1 1.6 3.0 4 0 0 4 4 4 1 Zinc knuckle N6-adenineMlase PF10237.9 EMC82987.1 - 0.063 13.1 0.0 0.095 12.5 0.0 1.4 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase DHHC PF01529.20 EMC82987.1 - 0.22 11.6 29.4 0.085 13.0 5.5 2.6 1 1 1 2 2 2 0 DHHC palmitoyltransferase PI3_PI4_kinase PF00454.27 EMC82988.1 - 2.6e-68 230.5 0.0 3.2e-68 230.2 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase SepSecS PF05889.13 EMC82989.1 - 7.4e-179 594.4 0.0 8.6e-179 594.2 0.0 1.0 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Beta_elim_lyase PF01212.21 EMC82989.1 - 2.1e-05 23.9 0.0 3.1e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Pyridoxal_deC PF00282.19 EMC82989.1 - 0.06 12.0 0.1 1.1 7.9 0.0 2.1 1 1 1 2 2 2 0 Pyridoxal-dependent decarboxylase conserved domain EPTP PF03736.17 EMC82990.1 - 2.5e-72 238.6 21.7 4.9e-13 48.8 0.1 7.3 7 0 0 7 7 7 7 EPTP domain LRR_8 PF13855.6 EMC82990.1 - 6.7e-20 70.6 7.9 4.4e-15 55.2 1.1 2.5 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EMC82990.1 - 4.7e-07 30.0 1.6 0.00018 21.8 0.5 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC82990.1 - 2e-06 27.8 0.2 1.4e-05 25.1 0.0 2.3 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EMC82990.1 - 0.0057 17.0 2.5 39 5.4 0.0 4.3 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_9 PF14580.6 EMC82990.1 - 0.063 12.8 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Leucine-rich repeat LRR_6 PF13516.6 EMC82990.1 - 0.19 11.8 0.6 44 4.5 0.1 3.4 3 0 0 3 3 3 0 Leucine Rich repeat DUF2353 PF09789.9 EMC82991.1 - 1.9e-91 306.7 26.0 2.8e-91 306.2 26.0 1.2 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) CorA PF01544.18 EMC82991.1 - 0.005 16.2 9.0 0.005 16.2 9.0 2.3 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein Csm1_N PF18504.1 EMC82991.1 - 0.0068 16.7 28.6 0.027 14.8 2.2 5.4 5 0 0 5 5 5 2 Csm1 N-terminal domain HrpB7 PF09486.10 EMC82991.1 - 0.012 16.0 7.5 0.012 16.0 7.5 2.5 3 0 0 3 3 2 0 Bacterial type III secretion protein (HrpB7) Atg14 PF10186.9 EMC82991.1 - 0.013 14.6 22.2 0.38 9.8 0.1 3.2 1 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Sec34 PF04136.15 EMC82991.1 - 0.028 14.3 2.2 0.028 14.3 2.2 3.3 3 1 1 4 4 3 0 Sec34-like family TSC22 PF01166.18 EMC82991.1 - 0.048 14.0 0.1 0.048 14.0 0.1 5.2 5 1 0 5 5 5 0 TSC-22/dip/bun family DUF2757 PF10955.8 EMC82991.1 - 0.056 13.7 0.9 0.12 12.6 0.2 2.0 2 0 0 2 2 1 0 Protein of unknown function (DUF2757) Peptidase_M27 PF01742.17 EMC82991.1 - 0.079 12.1 0.6 0.13 11.4 0.6 1.2 1 0 0 1 1 1 0 Clostridial neurotoxin zinc protease TPR_MLP1_2 PF07926.12 EMC82991.1 - 0.085 12.9 30.5 0.19 11.8 0.9 4.5 4 1 0 4 4 4 0 TPR/MLP1/MLP2-like protein GAS PF13851.6 EMC82991.1 - 0.23 10.8 33.8 0.052 12.9 5.6 4.0 2 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding LPP PF04728.13 EMC82991.1 - 0.25 11.8 10.0 8 6.9 1.9 4.2 4 0 0 4 4 4 0 Lipoprotein leucine-zipper Prefoldin PF02996.17 EMC82991.1 - 0.32 10.9 15.9 0.62 10.0 1.0 4.2 4 0 0 4 4 4 0 Prefoldin subunit DivIVA PF05103.13 EMC82991.1 - 0.32 11.1 20.5 0.089 12.9 7.0 3.0 3 0 0 3 3 3 0 DivIVA protein MitMem_reg PF13012.6 EMC82991.1 - 0.45 11.0 5.9 3 8.3 5.8 2.5 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function THP2 PF09432.10 EMC82991.1 - 0.45 10.6 8.0 0.64 10.1 6.0 2.3 2 1 0 2 2 2 0 Tho complex subunit THP2 Laminin_II PF06009.12 EMC82991.1 - 0.49 10.4 18.8 0.62 10.1 0.5 4.2 3 1 1 4 4 4 0 Laminin Domain II LMBR1 PF04791.16 EMC82991.1 - 0.55 9.1 7.8 0.9 8.4 7.8 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4164 PF13747.6 EMC82991.1 - 0.64 10.3 19.0 0.41 11.0 6.8 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF4164) FapA PF03961.13 EMC82991.1 - 0.68 8.5 17.2 0.18 10.4 2.2 2.8 1 1 2 3 3 3 0 Flagellar Assembly Protein A OEP PF02321.18 EMC82991.1 - 0.77 9.5 11.4 1.9 8.3 11.4 1.7 1 0 0 1 1 1 0 Outer membrane efflux protein DUF4298 PF14131.6 EMC82991.1 - 0.81 9.7 9.9 5.2 7.1 1.0 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4298) dCache_2 PF08269.11 EMC82991.1 - 1.3 8.2 8.4 0.14 11.3 1.9 2.2 2 0 0 2 2 2 0 Cache domain DUF4482 PF14818.6 EMC82991.1 - 1.4 9.8 26.3 0.77 10.6 2.6 4.0 4 1 0 4 4 3 0 Domain of unknown function (DUF4482) Tho2 PF11262.8 EMC82991.1 - 1.8 7.7 8.3 0.54 9.4 4.0 2.2 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 DUF1664 PF07889.12 EMC82991.1 - 1.9 8.5 15.5 14 5.8 4.5 4.1 2 1 3 5 5 5 0 Protein of unknown function (DUF1664) DUF2959 PF11172.8 EMC82991.1 - 2.6 8.2 13.0 0.93 9.6 8.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2959) RasGAP_C PF03836.15 EMC82991.1 - 2.8 8.1 19.0 2.6 8.2 1.5 3.8 4 0 0 4 4 4 0 RasGAP C-terminus KLRAQ PF10205.9 EMC82991.1 - 3.5 7.9 22.6 19 5.5 0.5 4.1 3 1 0 3 3 3 0 Predicted coiled-coil domain-containing protein bZIP_1 PF00170.21 EMC82991.1 - 3.8 7.7 20.9 0.37 10.9 1.4 5.0 4 0 0 4 4 4 0 bZIP transcription factor CALCOCO1 PF07888.11 EMC82991.1 - 5 5.9 31.2 0.031 13.1 21.5 2.1 2 1 1 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like Seryl_tRNA_N PF02403.22 EMC82991.1 - 5.6 7.2 24.1 1.5 9.1 1.6 4.1 3 1 2 5 5 4 0 Seryl-tRNA synthetase N-terminal domain Chibby PF14645.6 EMC82991.1 - 5.8 7.4 8.9 14 6.1 3.9 3.1 2 1 0 2 2 2 0 Chibby family FlaC_arch PF05377.11 EMC82991.1 - 6.2 7.3 16.9 28 5.2 0.1 5.1 5 1 0 5 5 5 0 Flagella accessory protein C (FlaC) Lebercilin PF15619.6 EMC82991.1 - 6.6 6.3 35.7 2.7 7.6 16.1 3.9 1 1 1 2 2 1 0 Ciliary protein causing Leber congenital amaurosis disease Cob_adeno_trans PF01923.18 EMC82991.1 - 7.1 6.7 9.3 40 4.3 2.8 3.4 1 1 2 3 3 3 0 Cobalamin adenosyltransferase Sod_Cu PF00080.20 EMC82992.1 - 3.4e-32 111.6 0.0 4.2e-32 111.2 0.0 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) HA2 PF04408.23 EMC82993.1 - 8.7e-24 83.9 0.2 1.8e-23 82.9 0.2 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EMC82993.1 - 9.1e-23 80.4 0.0 2.2e-22 79.2 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EMC82993.1 - 1.2e-12 48.1 0.0 2.9e-12 46.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EMC82993.1 - 5.7e-07 29.5 0.0 1.4e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 EMC82993.1 - 0.00014 22.3 0.0 0.00033 21.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EMC82993.1 - 0.00067 19.9 0.8 0.0098 16.2 0.8 2.7 1 1 0 1 1 1 1 AAA domain SRP54 PF00448.22 EMC82993.1 - 0.0024 17.5 0.0 0.0072 16.0 0.0 1.8 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain ResIII PF04851.15 EMC82993.1 - 0.003 17.6 0.0 0.41 10.6 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_25 PF13481.6 EMC82993.1 - 0.011 15.3 0.0 0.029 14.0 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EMC82993.1 - 0.013 15.3 0.0 0.027 14.2 0.0 1.5 1 1 0 1 1 1 0 AAA domain Flavi_DEAD PF07652.14 EMC82993.1 - 0.016 15.1 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_29 PF13555.6 EMC82993.1 - 0.043 13.6 0.0 0.097 12.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain HTH_IclR PF09339.10 EMC82993.1 - 0.12 12.2 0.1 0.36 10.7 0.1 1.8 2 0 0 2 2 2 0 IclR helix-turn-helix domain IstB_IS21 PF01695.17 EMC82993.1 - 0.13 12.0 0.0 19 5.0 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_23 PF13476.6 EMC82993.1 - 0.19 12.2 0.0 0.48 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain RRM_1 PF00076.22 EMC82994.1 - 8.8e-07 28.7 0.0 1.8e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PCAF_N PF06466.11 EMC82995.1 - 0.46 10.0 6.9 0.2 11.2 4.5 1.6 1 1 0 2 2 2 0 PCAF (P300/CBP-associated factor) N-terminal domain LRR_8 PF13855.6 EMC82996.1 - 7.7e-16 57.6 12.7 7.2e-11 41.7 5.2 2.6 1 1 1 2 2 2 2 Leucine rich repeat 7tm_2 PF00002.24 EMC82996.1 - 9.1e-13 48.1 7.4 1.6e-12 47.3 7.4 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 EMC82996.1 - 1.3e-07 32.0 0.0 1.3e-07 32.0 0.0 3.2 4 0 0 4 4 3 1 GPCR proteolysis site, GPS, motif I-set PF07679.16 EMC82996.1 - 2.1e-06 27.7 0.0 5.6e-06 26.3 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin I-set domain LRR_4 PF12799.7 EMC82996.1 - 4.7e-05 23.7 13.7 0.0012 19.2 1.8 2.9 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) ig PF00047.25 EMC82996.1 - 0.00065 19.8 0.2 0.0022 18.1 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin domain HRM PF02793.22 EMC82996.1 - 0.0011 19.2 1.0 0.003 17.8 1.0 1.8 1 0 0 1 1 1 1 Hormone receptor domain LRR_5 PF13306.6 EMC82996.1 - 0.0081 16.1 0.0 0.026 14.5 0.0 1.9 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EMC82996.1 - 0.016 15.7 4.8 1.4 9.7 0.3 3.7 2 0 0 2 2 2 0 Leucine Rich Repeat LRR_9 PF14580.6 EMC82996.1 - 0.16 11.5 0.3 0.29 10.6 0.3 1.4 1 0 0 1 1 1 0 Leucine-rich repeat TPKR_C2 PF16920.5 EMC82996.1 - 0.85 9.8 4.1 1.5 9.0 1.4 2.8 2 0 0 2 2 2 0 Tyrosine-protein kinase receptor C2 Ig-like domain EF-hand_7 PF13499.6 EMC82997.1 - 6.6e-25 87.3 3.8 3.3e-18 65.9 0.3 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EMC82997.1 - 2.9e-21 73.4 10.6 7.4e-08 31.4 0.1 3.9 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EMC82997.1 - 3.6e-18 63.9 9.8 7e-06 25.6 0.1 4.3 5 0 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 EMC82997.1 - 1.5e-17 62.2 3.6 1.1e-05 24.6 0.1 3.8 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EMC82997.1 - 3.1e-13 49.3 11.4 2.1e-05 24.3 1.7 4.5 2 1 3 5 5 5 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EMC82997.1 - 6.1e-08 33.0 3.4 2.5e-05 24.5 0.4 3.6 1 1 2 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EMC82997.1 - 0.00023 21.1 2.2 0.012 15.6 0.1 3.0 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EMC82997.1 - 0.0028 17.9 0.4 10 6.5 0.1 3.3 2 1 0 2 2 2 2 EF-hand domain Dockerin_1 PF00404.18 EMC82997.1 - 0.0052 16.9 0.2 0.29 11.4 0.0 2.4 1 1 1 2 2 2 2 Dockerin type I domain Caleosin PF05042.13 EMC82997.1 - 0.079 12.9 6.0 4.2 7.3 0.1 3.4 2 1 1 3 3 3 0 Caleosin related protein ParcG PF10274.9 EMC82998.1 - 5.9e-46 156.9 0.0 7.8e-46 156.5 0.0 1.1 1 0 0 1 1 1 1 Parkin co-regulated protein HEAT_EZ PF13513.6 EMC82998.1 - 0.12 12.9 0.5 1.3 9.6 0.1 2.2 1 1 1 2 2 2 0 HEAT-like repeat LRR_8 PF13855.6 EMC82999.1 - 5.3e-86 282.3 56.4 4.7e-13 48.7 3.5 10.4 4 4 6 10 10 10 10 Leucine rich repeat LRR_5 PF13306.6 EMC82999.1 - 3.3e-34 117.6 5.7 5.6e-09 36.0 0.1 5.2 4 0 0 4 4 4 4 BspA type Leucine rich repeat region (6 copies) EGF PF00008.27 EMC82999.1 - 5.7e-33 112.9 164.2 5.1e-08 33.1 7.7 12.4 13 0 0 13 13 10 8 EGF-like domain LRR_4 PF12799.7 EMC82999.1 - 1e-30 105.3 62.6 4.2e-05 23.8 0.1 12.0 8 4 6 15 15 15 10 Leucine Rich repeats (2 copies) Laminin_G_1 PF00054.23 EMC82999.1 - 1.3e-26 93.3 0.0 2.3e-26 92.6 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain Laminin_G_2 PF02210.24 EMC82999.1 - 3.7e-23 82.5 0.0 7.1e-23 81.6 0.0 1.5 1 0 0 1 1 1 1 Laminin G domain LRR_9 PF14580.6 EMC82999.1 - 1.1e-21 77.1 16.2 7.1e-07 28.9 0.4 4.6 4 0 0 4 4 4 4 Leucine-rich repeat LRRCT PF01463.24 EMC82999.1 - 1.2e-17 62.9 6.4 0.0032 17.9 0.1 6.2 5 0 0 5 5 5 4 Leucine rich repeat C-terminal domain LRRNT PF01462.18 EMC82999.1 - 4e-16 58.2 57.2 2.1e-08 33.6 3.3 8.8 9 0 0 9 9 9 3 Leucine rich repeat N-terminal domain hEGF PF12661.7 EMC82999.1 - 3.6e-14 52.8 135.7 1.4e-06 28.7 5.7 13.8 13 0 0 13 13 12 8 Human growth factor-like EGF FXa_inhibition PF14670.6 EMC82999.1 - 0.0054 17.0 4.2 0.0054 17.0 4.2 11.8 8 4 3 11 11 9 4 Coagulation Factor Xa inhibitory site LRR_1 PF00560.33 EMC82999.1 - 0.038 14.5 51.4 3.2 8.7 0.6 14.0 17 2 0 17 17 12 0 Leucine Rich Repeat TPKR_C2 PF16920.5 EMC82999.1 - 1.2 9.3 16.5 9.7 6.4 0.5 6.3 5 0 0 5 5 5 0 Tyrosine-protein kinase receptor C2 Ig-like domain HTH_psq PF05225.16 EMC83000.1 - 1.5e-24 85.4 0.0 5.1e-16 58.1 0.0 2.5 2 0 0 2 2 2 2 helix-turn-helix, Psq domain DUF2428 PF10350.9 EMC83000.1 - 0.011 14.9 0.8 0.5 9.6 0.0 2.6 2 0 0 2 2 2 0 Putative death-receptor fusion protein (DUF2428) DUF4553 PF15090.6 EMC83001.1 - 7.5e-149 496.8 27.9 7.5e-149 496.8 27.9 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4553) Staphostatin_A PF09022.10 EMC83001.1 - 0.078 12.9 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 Staphostatin A DUF4678 PF15727.5 EMC83001.1 - 0.82 8.9 7.0 0.047 13.0 0.3 2.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4678) Cnd3 PF12719.7 EMC83002.1 - 2.3e-83 279.8 2.6 2.3e-83 279.8 2.6 3.2 3 2 1 4 4 4 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 EMC83002.1 - 1e-09 38.6 4.0 0.051 14.0 0.3 5.3 5 1 0 5 5 5 3 HEAT repeats HEAT PF02985.22 EMC83002.1 - 5.6e-08 32.4 7.7 0.93 9.9 0.0 8.2 9 0 0 9 9 9 2 HEAT repeat UVR PF02151.19 EMC83002.1 - 0.00025 20.7 0.2 0.00025 20.7 0.2 3.0 3 0 0 3 3 3 1 UvrB/uvrC motif HEAT_EZ PF13513.6 EMC83002.1 - 0.00027 21.4 5.7 4.3 7.9 0.1 4.6 3 1 1 4 4 4 3 HEAT-like repeat P16-Arc PF04699.14 EMC83002.1 - 0.065 13.7 0.1 0.43 11.1 0.1 2.5 1 0 0 1 1 1 0 ARP2/3 complex 16 kDa subunit (p16-Arc) Cnd1 PF12717.7 EMC83002.1 - 0.76 9.8 14.4 0.29 11.2 0.4 4.8 4 1 1 5 5 5 0 non-SMC mitotic condensation complex subunit 1 DivIC PF04977.15 EMC83003.1 - 0.026 14.3 0.4 0.026 14.3 0.4 7.1 2 2 7 9 9 9 0 Septum formation initiator PhosphMutase PF10143.9 EMC83003.1 - 8.5 6.2 14.8 2.9 7.7 7.0 2.9 1 1 1 3 3 3 0 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Med28 PF11594.8 EMC83004.1 - 6.2e-24 84.6 2.0 2.5e-18 66.5 1.0 2.0 1 1 1 2 2 2 2 Mediator complex subunit 28 Filament PF00038.21 EMC83004.1 - 0.0046 16.6 1.3 0.0049 16.5 1.3 1.1 1 0 0 1 1 1 1 Intermediate filament protein HTH_34 PF13601.6 EMC83004.1 - 0.0066 16.6 0.0 0.014 15.6 0.0 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain ISG65-75 PF11727.8 EMC83004.1 - 0.086 12.1 0.1 0.11 11.7 0.1 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein Sec2p PF06428.11 EMC83004.1 - 0.12 12.4 4.3 0.17 11.9 4.3 1.2 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p cwf21 PF08312.12 EMC83004.1 - 0.49 10.6 3.9 0.82 9.9 1.6 2.3 2 1 0 2 2 2 0 cwf21 domain Peptidase_M17 PF00883.21 EMC83005.1 - 1.9e-121 405.2 0.0 2.4e-121 404.8 0.0 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 EMC83005.1 - 2e-19 69.7 0.0 5.1e-19 68.4 0.0 1.7 1 0 0 1 1 1 1 Cytosol aminopeptidase family, N-terminal domain Claudin_3 PF06653.11 EMC83006.1 - 0.0015 18.5 10.9 0.0085 16.0 10.9 2.1 1 1 0 1 1 1 1 Tight junction protein, Claudin-like PMP22_Claudin PF00822.20 EMC83006.1 - 0.0019 18.1 2.5 0.0028 17.6 2.5 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC83006.1 - 0.2 11.4 9.8 3.5 7.3 0.0 2.4 2 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction LIM_bind PF01803.16 EMC83007.1 - 1.7e-55 188.2 10.6 4.5e-44 150.8 0.5 2.8 2 1 1 3 3 3 2 LIM-domain binding protein LID PF17916.1 EMC83007.1 - 1.7e-18 65.9 2.5 3.2e-18 65.1 2.5 1.5 1 0 0 1 1 1 1 LIM interaction domain (LID) DTHCT PF08070.11 EMC83007.1 - 0.016 16.0 2.5 0.051 14.3 2.5 1.8 1 0 0 1 1 1 0 DTHCT (NUC029) region zf-DNL PF05180.12 EMC83007.1 - 0.085 12.8 0.2 0.17 11.9 0.2 1.4 1 0 0 1 1 1 0 DNL zinc finger Coilin_N PF15862.5 EMC83007.1 - 0.12 12.2 2.6 0.23 11.2 2.6 1.5 1 0 0 1 1 1 0 Coilin N-terminus Vpu PF00558.19 EMC83007.1 - 0.52 10.1 1.6 6.8 6.5 0.0 2.8 3 0 0 3 3 3 0 Vpu protein DUF747 PF05346.11 EMC83008.1 - 8.4e-108 360.6 19.5 1.1e-107 360.2 19.5 1.1 1 0 0 1 1 1 1 Eukaryotic membrane protein family DASH_Dad4 PF08650.10 EMC83008.1 - 0.04 13.9 3.9 0.25 11.4 2.2 2.3 2 0 0 2 2 2 0 DASH complex subunit Dad4 FGF-BP1 PF06473.12 EMC83009.1 - 1.8e-52 178.4 0.2 2.2e-52 178.2 0.2 1.1 1 0 0 1 1 1 1 FGF binding protein 1 (FGF-BP1) Consortin_C PF15281.6 EMC83009.1 - 0.15 12.0 0.0 0.29 11.1 0.0 1.6 1 1 0 1 1 1 0 Consortin C-terminus FGF-BP1 PF06473.12 EMC83010.1 - 7.2e-63 212.5 16.3 1.5e-62 211.4 16.3 1.5 1 1 0 1 1 1 1 FGF binding protein 1 (FGF-BP1) Rib_hydrolayse PF02267.17 EMC83011.1 - 8.4e-94 313.5 0.0 9.5e-94 313.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosyl cyclase F-box-like PF12937.7 EMC83012.1 - 1.9e-15 56.4 0.1 6.4e-15 54.8 0.1 2.0 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 EMC83012.1 - 9.6e-11 41.8 2.8 0.00011 22.5 0.0 3.8 3 1 0 3 3 3 2 Leucine Rich repeats (2 copies) F-box PF00646.33 EMC83012.1 - 1.2e-10 41.0 0.8 9.1e-10 38.2 0.0 2.8 3 0 0 3 3 3 1 F-box domain LRR_6 PF13516.6 EMC83012.1 - 1.7e-10 40.0 3.3 0.014 15.4 0.0 4.6 4 0 0 4 4 4 3 Leucine Rich repeat LRR_1 PF00560.33 EMC83012.1 - 1.2e-06 28.2 1.3 1.6 9.6 0.0 5.4 4 0 0 4 4 4 2 Leucine Rich Repeat Hemerythrin PF01814.23 EMC83012.1 - 6.6e-06 26.8 5.4 0.00021 21.9 0.4 2.1 1 1 1 2 2 2 2 Hemerythrin HHE cation binding domain LRR_8 PF13855.6 EMC83012.1 - 0.00082 19.1 1.3 0.62 9.9 0.1 3.6 2 1 0 2 2 2 2 Leucine rich repeat F-box_4 PF15966.5 EMC83012.1 - 0.0084 16.0 0.1 0.049 13.5 0.0 2.4 3 0 0 3 3 3 1 F-box PRANC PF09372.10 EMC83012.1 - 0.15 12.4 2.2 0.18 12.1 0.0 2.3 3 0 0 3 3 3 0 PRANC domain FTCD_C PF04961.12 EMC83012.1 - 0.28 10.9 2.6 2 8.1 1.5 2.4 1 1 0 2 2 2 0 Formiminotransferase-cyclodeaminase DUF5523 PF17661.1 EMC83013.1 - 8.7e-77 258.2 19.7 8.7e-77 258.2 19.7 2.6 2 1 0 2 2 2 1 Family of unknown function (DUF5523) CC2D2AN-C2 PF15625.6 EMC83013.1 - 1.5e-59 200.7 0.1 2.8e-59 199.7 0.1 1.5 1 0 0 1 1 1 1 CC2D2A N-terminal C2 domain C2 PF00168.30 EMC83013.1 - 4.9e-09 36.4 0.2 1.8e-05 25.0 0.1 2.8 2 0 0 2 2 2 2 C2 domain DUF3987 PF13148.6 EMC83013.1 - 0.035 13.1 11.2 0.094 11.7 11.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) ZnuA PF01297.17 EMC83013.1 - 0.27 10.6 2.6 0.6 9.5 2.6 1.5 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic Mit_KHE1 PF10173.9 EMC83013.1 - 0.29 11.2 5.4 1 9.4 5.4 2.0 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related GIDA_assoc PF13932.6 EMC83013.1 - 1.9 8.6 13.1 0.089 13.0 5.2 2.8 3 0 0 3 3 3 0 GidA associated domain EMC3_TMCO1 PF01956.16 EMC83013.1 - 2.5 7.8 5.0 6.9 6.4 5.0 1.8 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DUF4407 PF14362.6 EMC83013.1 - 3.3 7.0 7.9 4.9 6.4 5.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) TMPIT PF07851.13 EMC83013.1 - 3.7 6.7 8.3 10 5.2 8.3 1.7 1 0 0 1 1 1 0 TMPIT-like protein C1q PF00386.21 EMC83014.1 - 9.7e-39 132.5 0.0 1.3e-38 132.1 0.0 1.2 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 EMC83014.1 - 4.5e-16 58.4 57.7 6e-09 35.5 25.5 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) BclA_C PF18573.1 EMC83014.1 - 0.021 14.7 0.0 0.036 14.0 0.0 1.3 1 0 0 1 1 1 0 BclA C-terminal domain RRM_7 PF16367.5 EMC83015.1 - 2.4e-38 130.1 0.0 2e-36 124.0 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif CEBP_ZZ PF16366.5 EMC83015.1 - 4.5e-21 74.8 5.2 1.1e-20 73.6 5.2 1.7 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.22 EMC83015.1 - 3.5e-12 46.0 0.0 7.2e-07 28.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-U1 PF06220.12 EMC83015.1 - 0.07 12.9 0.3 0.2 11.5 0.3 1.7 1 0 0 1 1 1 0 U1 zinc finger HSP20 PF00011.21 EMC83015.1 - 0.14 12.4 0.0 0.46 10.7 0.0 1.8 2 0 0 2 2 2 0 Hsp20/alpha crystallin family zf-B_box PF00643.24 EMC83015.1 - 0.36 11.0 5.9 0.85 9.8 5.9 1.5 1 0 0 1 1 1 0 B-box zinc finger LAP1C PF05609.12 EMC83017.1 - 2.1 7.4 17.0 2.3 7.2 17.0 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CDC45 PF02724.14 EMC83017.1 - 6.9 4.8 16.4 8.1 4.6 16.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Homeodomain PF00046.29 EMC83018.1 - 2.8e-21 75.1 2.0 3.5e-21 74.8 2.0 1.1 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC83018.1 - 0.016 15.1 0.0 0.024 14.6 0.0 1.3 1 0 0 1 1 1 0 Homeobox KN domain Homez PF11569.8 EMC83018.1 - 0.07 12.6 0.0 0.07 12.6 0.0 1.3 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Ras PF00071.22 EMC83019.1 - 5.3e-40 136.7 0.1 7.2e-40 136.2 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC83019.1 - 2.1e-27 95.7 0.1 3.3e-27 95.1 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC83019.1 - 1.4e-11 44.1 0.1 1.8e-11 43.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EMC83019.1 - 0.00015 21.3 0.2 0.00019 20.9 0.2 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 EMC83019.1 - 0.084 12.6 0.1 0.19 11.4 0.1 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Sulfotransfer_1 PF00685.27 EMC83020.1 - 5.8e-38 130.9 0.4 7.9e-38 130.5 0.4 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC83020.1 - 1.1e-14 55.4 0.2 3.1e-09 37.5 0.1 2.4 1 1 1 2 2 2 2 Sulfotransferase family Sulfotransfer_2 PF03567.14 EMC83020.1 - 0.0027 17.6 0.2 0.0064 16.4 0.2 1.6 1 0 0 1 1 1 1 Sulfotransferase family zf-H2C2_5 PF13909.6 EMC83021.1 - 1.1e-05 25.0 0.9 1.1e-05 25.0 0.9 4.2 4 0 0 4 4 4 2 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 EMC83021.1 - 1.8e-05 24.9 0.5 1.8e-05 24.9 0.5 5.3 5 0 0 5 5 5 1 Zinc-finger double domain zf-C2H2 PF00096.26 EMC83021.1 - 0.00076 19.8 30.1 0.18 12.3 0.2 5.5 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC83021.1 - 0.42 11.6 29.4 0.93 10.5 2.2 5.8 5 0 0 5 5 5 0 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 EMC83021.1 - 2.6 7.8 11.2 7.6 6.3 0.6 4.9 4 0 0 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain Sugar_tr PF00083.24 EMC83022.1 - 1e-103 347.6 28.0 1.4e-103 347.2 28.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMC83022.1 - 1.3e-23 83.5 29.5 2.5e-17 62.8 5.7 2.9 1 1 2 3 3 3 2 Major Facilitator Superfamily Otopetrin PF03189.13 EMC83023.1 - 2.9e-50 171.4 19.7 2.7e-20 72.6 6.7 3.7 2 1 1 3 3 3 3 Otopetrin DUF1345 PF07077.11 EMC83023.1 - 0.0052 16.5 4.4 2.5 7.7 1.0 3.4 2 1 1 3 3 3 3 Protein of unknown function (DUF1345) DUF2919 PF11143.8 EMC83023.1 - 1.3 9.4 13.8 0.13 12.6 2.5 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2919) zf-LYAR PF08790.11 EMC83025.1 - 1.3e-14 53.7 1.9 1.3e-14 53.7 1.9 2.6 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger zf-ACC PF17848.1 EMC83025.1 - 8.5e-06 25.7 4.1 2.8e-05 24.1 4.1 2.0 1 0 0 1 1 1 1 Acetyl-coA carboxylase zinc finger domain zf_UBZ PF18439.1 EMC83025.1 - 0.059 13.0 2.0 7.3 6.3 0.1 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger IBR PF01485.21 EMC83025.1 - 3.3 8.0 12.3 11 6.4 12.3 1.9 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-H2C2_2 PF13465.6 EMC83026.1 - 2.4e-40 135.2 50.2 1.9e-07 31.2 1.4 8.4 7 1 1 8 8 7 7 Zinc-finger double domain zf-C2H2 PF00096.26 EMC83026.1 - 7.1e-32 108.1 47.7 5.3e-06 26.6 1.1 7.9 7 0 0 7 7 7 6 Zinc finger, C2H2 type BTB PF00651.31 EMC83026.1 - 2e-25 89.2 0.8 4.2e-25 88.1 0.8 1.6 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.6 EMC83026.1 - 1.7e-20 71.9 43.9 0.00084 20.0 0.9 8.2 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC83026.1 - 2e-14 53.4 26.5 0.0031 17.7 0.7 7.8 7 0 0 7 7 7 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMC83026.1 - 1.3e-13 50.6 49.9 6.8e-05 22.8 0.3 7.7 7 0 0 7 7 7 4 C2H2-type zinc finger zf-met PF12874.7 EMC83026.1 - 3.5e-10 39.9 35.7 0.0051 17.1 0.6 8.3 8 0 0 8 8 8 4 Zinc-finger of C2H2 type zf_UBZ PF18439.1 EMC83026.1 - 9.1e-08 31.6 22.0 1 9.0 0.1 7.6 7 0 0 7 7 7 3 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 EMC83026.1 - 0.0021 18.2 27.6 0.58 10.3 2.0 5.3 2 2 5 7 7 7 4 Zinc ribbon domain GAGA PF09237.11 EMC83026.1 - 0.0038 17.0 12.8 0.15 11.9 0.1 4.9 2 2 3 5 5 5 2 GAGA factor ADK_lid PF05191.14 EMC83026.1 - 0.0098 15.9 16.5 7.4 6.7 0.0 5.5 4 1 1 5 5 5 1 Adenylate kinase, active site lid zf-C2HC_2 PF13913.6 EMC83026.1 - 0.03 14.2 28.0 0.46 10.4 0.5 6.4 6 0 0 6 6 6 0 zinc-finger of a C2HC-type zf-MYST PF17772.1 EMC83026.1 - 0.11 12.1 15.5 20 4.9 0.1 5.6 5 1 0 5 5 5 0 MYST family zinc finger domain DUF3268 PF11672.8 EMC83026.1 - 0.17 12.2 15.8 3 8.2 0.4 4.5 2 2 3 5 5 5 0 zinc-finger-containing domain FYVE PF01363.21 EMC83026.1 - 0.68 10.1 34.5 9.1 6.5 10.3 5.8 1 1 3 4 4 4 0 FYVE zinc finger BolA PF01722.18 EMC83026.1 - 0.74 10.1 5.4 12 6.2 0.3 4.3 2 2 1 3 3 3 0 BolA-like protein zf-RING_7 PF02591.15 EMC83026.1 - 0.89 9.8 0.0 0.89 9.8 0.0 5.2 6 1 0 6 6 5 0 C4-type zinc ribbon domain zf-C2H2_3rep PF18868.1 EMC83026.1 - 1.4 9.6 23.0 2.6 8.8 0.2 5.6 2 1 1 4 4 3 0 Zinc finger C2H2-type, 3 repeats ARS2 PF04959.13 EMC83026.1 - 2.3 8.6 6.9 10 6.5 0.1 3.1 1 1 2 3 3 3 0 Arsenite-resistance protein 2 XPA_N PF01286.18 EMC83026.1 - 7 6.8 20.4 9.8 6.3 0.5 6.2 6 0 0 6 6 6 0 XPA protein N-terminal Calcyon PF06387.11 EMC83027.1 - 5.5e-88 293.7 0.1 6.3e-88 293.5 0.1 1.0 1 0 0 1 1 1 1 D1 dopamine receptor-interacting protein (calcyon) MgsA_C PF12002.8 EMC83027.1 - 0.05 13.5 0.3 0.088 12.7 0.3 1.4 1 0 0 1 1 1 0 MgsA AAA+ ATPase C terminal DUF2448 PF10476.9 EMC83027.1 - 0.13 12.1 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) zf-LITAF-like PF10601.9 EMC83027.1 - 0.3 11.4 1.4 0.35 11.2 0.2 1.6 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain Syntaxin-18_N PF10496.9 EMC83028.1 - 1.4e-09 38.0 0.4 1.4e-09 38.0 0.4 2.3 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus Phage_Integr_2 PF13009.6 EMC83028.1 - 0.0004 19.6 0.5 0.00066 18.9 0.5 1.3 1 0 0 1 1 1 1 Putative phage integrase DUF5089 PF17002.5 EMC83028.1 - 0.97 9.3 6.9 0.12 12.2 0.3 2.2 2 1 1 3 3 3 0 Domain of unknown function (DUF5089) CHIP_TPR_N PF18391.1 EMC83028.1 - 1.4 9.7 5.5 2.5 9.0 0.7 3.0 2 1 0 2 2 2 0 CHIP N-terminal tetratricopeptide repeat domain Homeodomain PF00046.29 EMC83030.1 - 1.3e-21 76.1 4.7 2.1e-21 75.5 4.7 1.3 1 0 0 1 1 1 1 Homeodomain DUF2457 PF10446.9 EMC83030.1 - 0.43 9.7 8.9 0.53 9.4 8.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CYTL1 PF15153.6 EMC83031.1 - 1e-57 193.6 2.9 1.2e-57 193.3 2.9 1.0 1 0 0 1 1 1 1 Cytokine-like protein 1 DUF1599 PF07659.11 EMC83031.1 - 0.022 15.2 0.0 0.13 12.7 0.0 2.0 2 0 0 2 2 2 0 Nucleotide modification associated domain 1 Pkinase PF00069.25 EMC83032.1 - 6.1e-64 215.9 0.0 7.9e-64 215.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC83032.1 - 6e-36 124.0 0.0 8.3e-36 123.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC83032.1 - 1.7e-10 40.7 0.0 2.2e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EMC83032.1 - 0.00025 20.1 0.1 0.00039 19.5 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EMC83032.1 - 0.00093 18.1 0.0 0.0016 17.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMC83032.1 - 0.0024 17.9 0.2 0.0035 17.3 0.2 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Tfb5 PF06331.12 EMC83033.1 - 0.033 14.2 1.2 0.25 11.3 1.2 2.6 1 0 0 1 1 1 0 Transcription factor TFIIH complex subunit Tfb5 BAG6 PF12057.8 EMC83033.1 - 0.14 11.9 8.0 0.62 9.8 1.5 3.0 3 0 0 3 3 3 0 BCL2-associated athanogene 6 DUF4046 PF13255.6 EMC83033.1 - 0.37 11.4 12.2 0.31 11.6 3.5 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4046) DUF948 PF06103.11 EMC83033.1 - 0.54 10.6 8.8 1.5 9.1 0.8 3.2 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Polyoma_coat2 PF00761.20 EMC83033.1 - 0.71 9.5 3.9 1.1 8.9 1.8 2.4 2 0 0 2 2 2 0 Polyomavirus coat protein JAKMIP_CC3 PF16034.5 EMC83035.1 - 1.3e-85 286.4 20.9 1.3e-85 286.4 20.9 6.7 5 2 1 6 6 6 1 JAKMIP CC3 domain ADIP PF11559.8 EMC83035.1 - 0.0047 17.0 13.1 0.0047 17.0 13.1 8.9 5 4 5 10 10 10 2 Afadin- and alpha -actinin-Binding DUF1654 PF07867.11 EMC83035.1 - 0.027 14.2 0.2 0.14 11.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1654) WD40 PF00400.32 EMC83036.1 - 2.1e-07 31.5 4.7 1.6 9.7 0.1 6.3 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC83036.1 - 0.0013 18.9 0.0 17 5.8 0.0 4.5 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain TACC_C PF05010.14 EMC83037.1 - 3e-90 301.4 42.0 7.7e-90 300.1 42.0 1.7 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Il13Ra_Ig PF18001.1 EMC83037.1 - 0.017 15.2 1.1 0.067 13.3 0.6 2.3 2 0 0 2 2 2 0 Interleukin-13 receptor subunit alpha Ig-like domain BPTA PF17044.5 EMC83037.1 - 0.16 11.8 3.6 0.33 10.8 3.6 1.4 1 0 0 1 1 1 0 Borrelial persistence in ticks protein A DUF948 PF06103.11 EMC83037.1 - 0.75 10.1 10.7 1.6 9.1 0.7 4.4 4 1 1 5 5 5 0 Bacterial protein of unknown function (DUF948) MAD PF05557.13 EMC83037.1 - 1.6 7.0 39.6 0.17 10.2 22.8 2.3 1 1 1 2 2 2 0 Mitotic checkpoint protein ZapD PF07072.11 EMC83037.1 - 1.7 8.3 15.8 0.04 13.7 2.5 3.0 1 1 3 4 4 4 0 Cell division protein Tmpp129 PF10272.9 EMC83038.1 - 2.3e-144 481.1 4.5 2.6e-144 480.9 4.5 1.0 1 0 0 1 1 1 1 Putative transmembrane protein precursor C1_4 PF07975.12 EMC83038.1 - 0.0059 16.8 1.4 0.0059 16.8 1.4 2.6 1 1 1 2 2 2 1 TFIIH C1-like domain Dexa_ind PF15198.6 EMC83038.1 - 0.11 12.6 0.2 2.4 8.3 0.0 2.3 2 0 0 2 2 2 0 Dexamethasone-induced TLV_coat PF00429.19 EMC83039.1 - 1.3e-11 43.9 2.0 1.6e-11 43.7 2.0 1.0 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) SLBP_RNA_bind PF15247.6 EMC83040.1 - 8.8e-30 102.6 4.0 2.2e-29 101.4 4.0 1.7 1 0 0 1 1 1 1 Histone RNA hairpin-binding protein RNA-binding domain LOR PF04525.12 EMC83040.1 - 0.1 12.2 0.8 0.16 11.6 0.8 1.3 1 0 0 1 1 1 0 LURP-one-related FAM53 PF15242.6 EMC83041.1 - 1.7e-112 376.2 22.4 4.6e-112 374.8 22.4 1.7 1 1 0 1 1 1 1 Family of FAM53 DUF2043 PF09740.9 EMC83043.1 - 3.7e-40 136.9 0.0 3.7e-40 136.9 0.0 2.8 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2043) CLTH PF10607.9 EMC83044.1 - 2.5e-32 111.8 0.4 3.5e-32 111.3 0.4 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 EMC83044.1 - 0.016 15.2 4.9 0.16 12.0 0.0 3.0 3 0 0 3 3 3 0 RING-type zinc-finger 2-Hacid_dh_C PF02826.19 EMC83045.1 - 2.5e-57 193.1 0.0 3.6e-57 192.6 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EMC83045.1 - 5.6e-29 100.5 0.0 6.9e-29 100.2 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EMC83045.1 - 1.5e-05 25.2 0.0 3.2e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Cellsynth_D PF03500.13 EMC83045.1 - 0.016 15.1 0.0 0.053 13.4 0.0 1.8 2 0 0 2 2 2 0 Cellulose synthase subunit D XdhC_C PF13478.6 EMC83045.1 - 0.048 14.2 0.0 0.15 12.6 0.0 1.8 1 0 0 1 1 1 0 XdhC Rossmann domain Spond_N PF06468.13 EMC83046.1 - 1.3e-76 257.1 0.5 1.6e-76 256.7 0.5 1.1 1 0 0 1 1 1 1 Spondin_N TSP_1 PF00090.19 EMC83046.1 - 0.00062 19.9 3.6 0.0012 19.0 3.6 1.5 1 0 0 1 1 1 1 Thrombospondin type 1 domain EMP24_GP25L PF01105.24 EMC83047.1 - 2.6e-42 144.8 0.2 2.8e-42 144.7 0.2 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF4665 PF15679.5 EMC83047.1 - 0.0087 16.7 1.8 0.013 16.1 1.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4665) DASH_Spc34 PF08657.10 EMC83048.1 - 0.0064 16.3 0.4 0.0073 16.1 0.4 1.1 1 0 0 1 1 1 1 DASH complex subunit Spc34 Tautomerase_3 PF14832.6 EMC83048.1 - 0.11 12.8 0.0 0.15 12.3 0.0 1.2 1 0 0 1 1 1 0 Putative oxalocrotonate tautomerase enzyme I-set PF07679.16 EMC83049.1 - 6.5e-47 157.5 0.0 3.4e-17 62.3 0.0 3.4 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC83049.1 - 6.1e-41 138.9 0.1 3e-14 53.4 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 EMC83049.1 - 1.5e-29 102.0 0.1 1.1e-10 41.6 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 EMC83049.1 - 1.1e-26 93.0 0.0 4.5e-11 42.9 0.0 3.9 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 EMC83049.1 - 4.3e-19 68.7 0.8 0.00017 21.8 0.1 5.1 3 2 0 3 3 3 3 Immunoglobulin V-set domain Ig_6 PF18452.1 EMC83049.1 - 1.8e-10 40.2 0.1 0.042 13.4 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_4 PF16680.5 EMC83049.1 - 5.5e-08 33.0 0.3 0.0079 16.4 0.1 3.7 4 0 0 4 4 4 2 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 EMC83049.1 - 9.3e-07 29.2 0.0 0.066 13.6 0.0 3.5 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 EMC83049.1 - 3.5e-05 23.8 0.2 0.005 16.9 0.0 3.0 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 EMC83049.1 - 5.9e-05 23.1 0.1 1.6 8.8 0.0 3.3 3 0 0 3 3 3 2 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.8 EMC83049.1 - 0.00011 22.4 0.0 1.5 9.0 0.0 3.2 3 0 0 3 3 3 2 Natural killer cell receptor 2B4 G6B PF15096.6 EMC83049.1 - 0.021 14.6 0.0 2.2 8.0 0.0 2.4 2 0 0 2 2 2 0 G6B family zf-RRN7 PF11781.8 EMC83049.1 - 0.033 13.9 0.2 8.7 6.1 0.0 3.5 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 V-set_CD47 PF08204.11 EMC83049.1 - 0.17 11.9 0.2 2.1 8.3 0.0 2.2 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain HLH PF00010.26 EMC83050.1 - 6.8e-06 25.9 0.0 1.1e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Glyco_transf_29 PF00777.18 EMC83051.1 - 3.7e-77 259.3 0.0 4.5e-77 259.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) RNA_pol_Rpb1_5 PF04998.17 EMC83052.1 - 3.5e-103 344.7 0.1 8e-103 343.5 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_4 PF05000.17 EMC83052.1 - 7e-25 87.1 0.4 2.4e-24 85.4 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 RP-C_C PF11800.8 EMC83052.1 - 0.005 17.0 1.2 0.013 15.6 1.2 1.7 1 0 0 1 1 1 1 Replication protein C C-terminal region HMG_box PF00505.19 EMC83052.1 - 0.012 16.0 1.6 0.026 14.9 0.2 2.3 2 0 0 2 2 2 0 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC83052.1 - 0.16 12.6 2.1 0.23 12.1 0.3 2.2 2 0 0 2 2 2 0 HMG-box domain RNA_pol_Rpb1_1 PF04997.12 EMC83053.1 - 2.8e-10 40.0 3.3 3.4e-10 39.8 3.3 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 zf-RING_4 PF14570.6 EMC83053.1 - 0.031 14.1 3.5 0.031 14.1 3.5 2.1 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain N1221 PF07923.13 EMC83053.1 - 0.071 12.3 0.3 0.075 12.2 0.3 1.2 1 0 0 1 1 1 0 N1221-like protein Mitofilin PF09731.9 EMC83054.1 - 5e-211 702.8 42.3 5.9e-211 702.6 42.3 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein Fes1 PF08609.10 EMC83054.1 - 0.0056 17.5 3.6 0.0056 17.5 3.6 4.3 3 2 2 5 5 5 1 Nucleotide exchange factor Fes1 CAV_VP3 PF04771.12 EMC83054.1 - 0.046 13.9 0.0 0.097 12.8 0.0 1.5 1 0 0 1 1 1 0 Chicken anaemia virus VP-3 protein zf-RING_11 PF17123.5 EMC83054.1 - 0.14 12.0 0.1 0.31 10.8 0.1 1.6 1 0 0 1 1 1 0 RING-like zinc finger Ribosomal_L35p PF01632.19 EMC83055.1 - 7.5e-16 58.4 8.0 1e-15 58.0 8.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L35 IL33 PF15095.6 EMC83055.1 - 0.056 12.9 2.3 0.062 12.8 2.3 1.1 1 0 0 1 1 1 0 Interleukin 33 DUF3437 PF11919.8 EMC83055.1 - 0.1 12.5 0.3 0.24 11.3 0.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3437) TB2_DP1_HVA22 PF03134.19 EMC83056.1 - 7.9e-27 93.0 10.9 1.2e-26 92.4 10.9 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family DUF2306 PF10067.9 EMC83056.1 - 0.027 14.7 0.8 0.046 13.9 0.8 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2306) MHCassoc_trimer PF08831.10 EMC83056.1 - 0.071 13.1 0.5 0.13 12.2 0.5 1.4 1 0 0 1 1 1 0 Class II MHC-associated invariant chain trimerisation domain Snf7 PF03357.21 EMC83057.1 - 1.6e-40 138.5 15.2 1.6e-40 138.5 15.2 1.3 2 0 0 2 2 2 1 Snf7 zf-ZPR1 PF03367.13 EMC83057.1 - 0.014 15.3 0.7 0.014 15.3 0.7 1.7 2 0 0 2 2 2 0 ZPR1 zinc-finger domain AAA_6 PF12774.7 EMC83057.1 - 0.016 14.2 0.6 0.022 13.7 0.6 1.1 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region Cauli_AT PF03233.13 EMC83057.1 - 0.53 10.2 4.0 0.24 11.3 0.3 2.0 1 1 1 2 2 2 0 Aphid transmission protein NPV_P10 PF05531.12 EMC83057.1 - 2.7 8.5 5.2 11 6.5 0.4 2.9 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein CLTH PF10607.9 EMC83058.1 - 3.6e-32 111.3 0.0 1e-31 109.8 0.0 1.8 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 EMC83058.1 - 6.5e-06 26.1 0.2 1.5e-05 24.9 0.2 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EMC83058.1 - 0.016 15.6 1.7 0.018 15.4 0.2 2.0 2 0 0 2 2 2 0 Ring finger domain Prok-RING_4 PF14447.6 EMC83058.1 - 0.031 14.1 1.5 0.69 9.8 0.1 2.6 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 SnoaL_4 PF13577.6 EMC83058.1 - 0.18 11.9 0.0 1.8 8.7 0.0 2.2 2 0 0 2 2 2 0 SnoaL-like domain zf-RING_5 PF14634.6 EMC83058.1 - 1.2 9.1 3.9 0.54 10.3 1.1 1.9 2 0 0 2 2 2 0 zinc-RING finger domain V-set PF07686.17 EMC83059.1 - 4.6e-10 39.6 0.0 7.2e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC83059.1 - 0.00082 19.9 0.0 0.0024 18.4 0.0 1.8 2 1 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 EMC83059.1 - 0.00083 19.5 0.1 0.002 18.2 0.1 1.6 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC83059.1 - 0.019 15.0 0.0 0.068 13.3 0.0 1.8 1 1 0 1 1 1 0 Immunoglobulin I-set domain TMEM154 PF15102.6 EMC83059.1 - 0.031 14.2 0.0 0.056 13.4 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family V-set PF07686.17 EMC83060.1 - 8.6e-21 74.2 0.4 1.1e-20 73.8 0.4 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC83060.1 - 6e-05 23.6 0.9 0.00014 22.4 0.9 1.6 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC83060.1 - 0.00024 21.1 0.3 0.00045 20.2 0.3 1.4 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC83060.1 - 0.002 18.2 1.3 0.0067 16.6 1.3 1.8 1 1 0 1 1 1 1 Immunoglobulin domain Ig_6 PF18452.1 EMC83060.1 - 0.1 12.2 0.1 0.32 10.6 0.0 1.8 2 0 0 2 2 2 0 Immunoglobulin domain Izumo-Ig PF16706.5 EMC83060.1 - 0.19 11.8 0.3 1 9.5 0.2 2.1 1 1 1 2 2 2 0 Izumo-like Immunoglobulin domain Integrase_H2C2 PF17921.1 EMC83061.1 - 4.5e-13 49.1 0.0 1.1e-12 47.9 0.0 1.7 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 EMC83061.1 - 0.007 16.5 0.0 0.01 16.0 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain SET PF00856.28 EMC83062.1 - 4.3e-13 50.0 0.0 8.9e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 SET domain zf-MYND PF01753.18 EMC83062.1 - 1.8e-09 37.6 17.7 1.8e-09 37.6 17.7 2.7 3 0 0 3 3 3 1 MYND finger TPR_12 PF13424.6 EMC83062.1 - 0.0087 16.3 0.1 0.024 14.9 0.0 1.7 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF2315 PF10231.9 EMC83062.1 - 0.1 12.7 0.0 1.9 8.6 0.0 2.4 2 0 0 2 2 2 0 Apoptogenic protein 1 Lipocalin_7 PF14651.6 EMC83063.1 - 1.4e-31 109.1 2.4 1.5e-31 108.9 2.4 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin PF00061.23 EMC83063.1 - 7.1e-17 62.0 1.9 7.8e-17 61.8 1.9 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Thr_synth_N PF14821.6 EMC83064.1 - 9.4e-25 86.6 0.2 4.7e-24 84.4 0.0 2.4 3 0 0 3 3 3 1 Threonine synthase N terminus PALP PF00291.25 EMC83064.1 - 1.5e-15 57.4 0.0 1.6e-14 54.1 0.0 2.3 2 1 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme Forkhead PF00250.18 EMC83065.1 - 5.4e-34 116.3 0.0 8.4e-34 115.7 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain HNH_2 PF13391.6 EMC83065.1 - 0.28 11.3 1.1 0.62 10.2 0.1 2.1 2 1 0 2 2 2 0 HNH endonuclease 7tm_1 PF00001.21 EMC83066.1 - 5e-69 232.5 27.5 5.7e-69 232.4 27.5 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC83066.1 - 6.2e-09 35.6 32.8 7.1e-08 32.1 32.8 2.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC83066.1 - 0.001 18.7 28.6 0.0019 17.9 28.2 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC83066.1 - 0.0012 18.6 8.4 0.0012 18.6 8.4 2.5 3 0 0 3 3 3 1 Olfactory receptor Pkinase PF00069.25 EMC83067.1 - 2.2e-51 174.8 0.0 1.4e-37 129.5 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMC83067.1 - 5.2e-31 107.9 0.0 5.2e-23 81.6 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase PQQ_2 PF13360.6 EMC83067.1 - 1.9e-06 27.6 0.1 0.0015 18.2 0.1 2.5 1 1 1 2 2 2 2 PQQ-like domain Kinase-like PF14531.6 EMC83067.1 - 6.2e-05 22.5 0.0 0.00015 21.2 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC83067.1 - 0.0017 17.8 0.2 0.0049 16.3 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family TRAP-delta PF05404.12 EMC83067.1 - 0.0094 15.5 0.4 0.15 11.5 0.1 2.2 2 0 0 2 2 2 1 Translocon-associated protein, delta subunit precursor (TRAP-delta) Pkinase_fungal PF17667.1 EMC83067.1 - 0.014 14.1 0.0 0.029 13.2 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EMC83067.1 - 0.02 14.9 0.0 0.042 13.8 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Flagellar_put PF12611.8 EMC83067.1 - 0.089 12.6 0.1 0.27 11.1 0.1 1.9 1 0 0 1 1 1 0 Putative flagellar PQQ_3 PF13570.6 EMC83067.1 - 0.17 12.4 0.0 8 7.1 0.0 3.3 4 0 0 4 4 4 0 PQQ-like domain Rib_5-P_isom_A PF06026.14 EMC83068.1 - 5.5e-66 221.4 0.0 6.4e-66 221.2 0.0 1.0 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Peptidase_C93 PF06035.11 EMC83068.1 - 0.14 11.9 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 Bacterial transglutaminase-like cysteine proteinase BTLCP CoA_binding PF02629.19 EMC83070.1 - 5.8e-32 110.2 1.3 1.7e-31 108.7 0.2 2.1 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 EMC83070.1 - 3e-23 82.3 0.1 4.9e-23 81.6 0.1 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EMC83070.1 - 1.1e-08 35.0 0.0 2e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EMC83070.1 - 3.5e-05 24.3 0.0 9.3e-05 22.9 0.0 1.7 2 0 0 2 2 2 1 CoA binding domain Vinculin PF01044.19 EMC83071.1 - 5e-208 693.7 19.6 5.6e-208 693.5 19.6 1.0 1 0 0 1 1 1 1 Vinculin family I_LWEQ PF01608.17 EMC83071.1 - 0.016 15.5 3.9 0.016 15.5 3.9 4.2 3 2 0 3 3 3 0 I/LWEQ domain DUF4872 PF16169.5 EMC83071.1 - 0.14 11.9 0.7 5.3 6.8 0.0 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4872) Baculo_gp41 PF04700.12 EMC83071.1 - 0.26 11.1 2.3 1.1 9.0 0.0 2.6 3 0 0 3 3 3 0 Structural glycoprotein p40/gp41 conserved region HECT PF00632.25 EMC83072.1 - 9.9e-92 307.7 0.1 5.6e-91 305.2 0.0 2.0 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) Ank_2 PF12796.7 EMC83072.1 - 2.9e-35 120.7 2.1 7.2e-12 45.7 0.2 4.3 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC83072.1 - 2e-33 114.3 3.8 4e-11 43.2 0.1 6.2 3 1 3 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC83072.1 - 1e-27 93.1 3.7 2e-05 24.6 0.0 7.6 8 0 0 8 8 8 5 Ankyrin repeat Ank PF00023.30 EMC83072.1 - 5.8e-27 92.9 11.5 9.7e-07 29.0 0.1 7.8 8 0 0 8 8 8 5 Ankyrin repeat Ank_5 PF13857.6 EMC83072.1 - 6.5e-22 77.3 5.9 8.9e-08 32.3 0.1 4.6 1 1 2 4 4 4 4 Ankyrin repeats (many copies) CSD PF00313.22 EMC83073.1 - 1e-17 63.7 0.1 2.2e-17 62.7 0.1 1.6 1 1 0 1 1 1 1 'Cold-shock' DNA-binding domain zf-CCHC PF00098.23 EMC83073.1 - 9.1e-09 35.0 13.8 6.8e-05 22.8 2.7 2.5 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 EMC83073.1 - 0.42 10.4 10.4 0.15 11.8 1.6 2.4 2 0 0 2 2 2 0 Zinc knuckle Popeye PF04831.13 EMC83074.1 - 4.7e-52 175.9 2.0 5.6e-52 175.6 2.0 1.1 1 0 0 1 1 1 1 Popeye protein conserved region cNMP_binding PF00027.29 EMC83074.1 - 0.1 12.7 0.0 0.27 11.3 0.0 1.8 1 1 0 1 1 1 0 Cyclic nucleotide-binding domain Phage_holin_3_6 PF07332.11 EMC83074.1 - 0.11 12.6 2.4 0.17 11.9 2.4 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Peptidase_S9_N PF02897.15 EMC83075.1 - 9.9e-157 522.0 0.0 1.2e-156 521.7 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 EMC83075.1 - 1.6e-68 230.3 0.0 2.5e-68 229.7 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 EMC83075.1 - 0.077 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Putative esterase Hydrolase_4 PF12146.8 EMC83075.1 - 0.14 11.4 0.0 0.35 10.1 0.0 1.6 2 0 0 2 2 2 0 Serine aminopeptidase, S33 zf-H2C2_2 PF13465.6 EMC83076.1 - 8.6e-28 95.5 45.4 1.1e-07 31.9 1.1 5.7 5 0 0 5 5 5 5 Zinc-finger double domain zf-C2H2 PF00096.26 EMC83076.1 - 2e-16 59.4 47.1 1.9e-05 24.9 0.4 6.0 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC83076.1 - 7.6e-08 32.6 49.2 0.013 16.3 0.5 6.3 6 0 0 6 6 6 4 C2H2-type zinc finger SET PF00856.28 EMC83076.1 - 2.9e-07 31.0 0.2 1.2e-06 29.1 0.2 1.9 1 1 0 1 1 1 1 SET domain zf-C2H2_6 PF13912.6 EMC83076.1 - 5.6e-05 23.0 11.7 0.00064 19.6 4.4 5.3 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC83076.1 - 0.00013 22.2 29.6 0.011 15.9 0.5 5.4 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC83076.1 - 0.004 17.5 37.9 0.024 15.0 2.2 6.0 6 0 0 6 6 6 3 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 EMC83076.1 - 1.5 9.0 14.5 4.3 7.5 1.9 3.8 3 1 0 3 3 3 0 Zinc ribbon domain APG5 PF04106.12 EMC83077.1 - 7e-61 205.7 0.7 9e-61 205.4 0.7 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 Crystall PF00030.19 EMC83079.1 - 1.6e-126 412.8 0.9 4.5e-28 97.3 0.0 6.3 6 0 0 6 6 6 6 Beta/Gamma crystallin IL4_i_Ig PF18258.1 EMC83079.1 - 5.2e-18 65.1 2.6 0.051 13.8 0.0 8.1 5 2 2 8 8 8 5 Interleukin-4 inducing immunoglobulin-binding domain Ricin_B_lectin PF00652.22 EMC83079.1 - 7.2e-11 42.4 0.0 1.3e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.6 EMC83079.1 - 0.0002 22.0 0.0 0.24 12.1 0.0 2.5 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Inhibitor_I36 PF03995.13 EMC83079.1 - 0.056 13.4 0.1 8.4 6.4 0.0 4.2 5 0 0 5 5 5 0 Peptidase inhibitor family I36 Amidase PF01425.21 EMC83080.1 - 1.3e-128 429.8 0.0 6.2e-128 427.6 0.0 1.7 1 1 0 1 1 1 1 Amidase Iwr1 PF08574.10 EMC83081.1 - 0.0022 18.9 2.9 0.0057 17.6 2.9 1.6 1 0 0 1 1 1 1 Transcription factor Iwr1 FAM176 PF14851.6 EMC83081.1 - 0.062 13.0 1.7 0.098 12.3 1.7 1.3 1 0 0 1 1 1 0 FAM176 family BEN PF10523.9 EMC83082.1 - 2.6e-73 242.2 4.4 4e-21 75.0 0.0 4.5 4 0 0 4 4 4 4 BEN domain polyprenyl_synt PF00348.17 EMC83083.1 - 6e-20 71.4 0.1 9.4e-20 70.7 0.1 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase VirK PF06903.12 EMC83083.1 - 0.0058 16.7 0.0 0.011 15.8 0.0 1.5 1 0 0 1 1 1 1 VirK protein SOBP PF15279.6 EMC83084.1 - 1.5e-91 308.4 39.0 1.5e-91 308.4 39.0 3.2 3 1 0 3 3 3 1 Sine oculis-binding protein zf-FCS PF06467.14 EMC83084.1 - 0.0033 17.3 12.2 0.17 11.8 1.5 2.7 2 0 0 2 2 2 2 MYM-type Zinc finger with FCS sequence motif zf-C6H2 PF15801.5 EMC83084.1 - 0.65 10.4 9.8 2 8.8 6.1 2.9 2 1 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding SLED PF12140.8 EMC83085.1 - 3.6e-34 117.6 0.4 5.3e-34 117.1 0.4 1.3 1 0 0 1 1 1 1 SLED domain SAM_1 PF00536.30 EMC83085.1 - 9.6e-15 54.8 0.1 2e-14 53.8 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RBR PF17208.3 EMC83085.1 - 4.1e-11 43.4 6.0 9.5e-11 42.2 6.0 1.7 1 0 0 1 1 1 1 RNA binding Region SAM_2 PF07647.17 EMC83085.1 - 0.00053 20.1 0.0 0.00095 19.2 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 EMC83085.1 - 0.011 15.7 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Sec63 PF02889.16 EMC83086.1 - 6.3e-20 71.4 3.3 4.4e-09 35.9 0.8 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DnaJ PF00226.31 EMC83086.1 - 3.5e-17 62.3 0.0 8.9e-17 61.0 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain Presenilin PF01080.17 EMC83086.1 - 1.7 7.4 10.9 4.4 6.0 10.9 1.8 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 EMC83086.1 - 2.3 8.2 7.0 4.4 7.3 7.0 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region OSTMP1 PF09777.9 EMC83087.1 - 1.2e-73 247.3 7.7 1.4e-73 247.2 7.7 1.0 1 0 0 1 1 1 1 Osteopetrosis-associated transmembrane protein 1 precursor CECR6_TMEM121 PF14997.6 EMC83087.1 - 0.00072 19.4 0.1 0.0009 19.1 0.1 1.2 1 0 0 1 1 1 1 CECR6/TMEM121 family Hormone_recep PF00104.30 EMC83088.1 - 1.9e-34 119.0 0.0 2.4e-34 118.7 0.0 1.1 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 EMC83088.1 - 2.9e-17 62.9 4.7 1.1e-16 61.0 4.5 2.1 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) C1_2 PF03107.16 EMC83088.1 - 5.4 7.4 6.4 1.3 9.4 2.6 2.0 2 1 0 2 2 2 0 C1 domain AFG1_ATPase PF03969.16 EMC83089.1 - 6.2e-115 384.0 4.1 4.2e-111 371.3 0.9 2.0 1 1 1 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.6 EMC83089.1 - 7.1e-05 23.2 0.1 0.017 15.5 0.1 2.8 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EMC83089.1 - 0.00021 21.7 0.1 0.0011 19.4 0.0 2.3 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EMC83089.1 - 0.0019 18.5 0.0 0.0085 16.4 0.0 2.1 2 1 0 2 2 2 1 AAA domain UvrD-helicase PF00580.21 EMC83089.1 - 0.003 17.1 0.1 0.042 13.4 0.0 2.2 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_14 PF13173.6 EMC83089.1 - 0.0078 16.2 0.0 0.022 14.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EMC83089.1 - 0.015 15.2 0.0 0.069 13.1 0.0 2.1 2 1 1 3 3 3 0 NACHT domain AAA_19 PF13245.6 EMC83089.1 - 0.023 15.0 0.1 1.2 9.5 0.1 2.5 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EMC83089.1 - 0.051 13.1 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 EMC83089.1 - 0.083 12.9 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 EMC83089.1 - 0.084 12.8 0.1 0.24 11.3 0.1 1.9 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Mrx7 PF10906.8 EMC83089.1 - 0.085 13.1 0.1 0.23 11.7 0.1 1.7 1 0 0 1 1 1 0 MIOREX complex component 7 TniB PF05621.11 EMC83089.1 - 0.12 11.7 0.0 0.39 10.1 0.0 1.8 1 1 0 1 1 1 0 Bacterial TniB protein FOXO_KIX_bdg PF16675.5 EMC83092.1 - 1.6e-32 111.6 9.5 1.6e-32 111.6 9.5 2.5 2 1 1 3 3 3 1 KIX-binding domain of forkhead box O, CR2 FOXO-TAD PF16676.5 EMC83092.1 - 8.3e-22 77.3 7.0 2.1e-21 76.0 7.0 1.7 1 0 0 1 1 1 1 Transactivation domain of FOXO protein family Forkhead PF00250.18 EMC83092.1 - 4.3e-08 33.3 0.1 1.1e-07 32.0 0.1 1.7 1 0 0 1 1 1 1 Forkhead domain DUF1970 PF09301.10 EMC83092.1 - 0.04 14.2 0.7 0.3 11.3 0.1 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF1970) Arm PF00514.23 EMC83094.1 - 1.6e-09 37.5 8.8 0.096 12.8 0.0 7.3 8 0 0 8 8 8 4 Armadillo/beta-catenin-like repeat KAP PF05804.12 EMC83094.1 - 1.1e-07 30.5 16.2 1.2e-05 23.8 2.1 3.0 3 1 0 3 3 3 2 Kinesin-associated protein (KAP) PUL PF08324.11 EMC83094.1 - 0.00059 19.2 2.1 0.0037 16.5 0.3 3.0 1 1 2 4 4 4 1 PUL domain Arm_2 PF04826.13 EMC83094.1 - 0.0075 15.8 0.5 0.0075 15.8 0.5 4.5 3 2 2 5 5 5 2 Armadillo-like MyTH4 PF00784.17 EMC83094.1 - 0.17 12.4 0.6 0.64 10.5 0.0 2.3 2 0 0 2 2 2 0 MyTH4 domain PA26 PF04636.13 EMC83095.1 - 1.1e-210 700.2 1.9 1.2e-210 700.0 1.9 1.0 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) CMD PF02627.20 EMC83095.1 - 0.00036 20.5 0.0 0.0011 18.9 0.0 1.8 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family Cep57_CLD PF14073.6 EMC83096.1 - 5.6e-64 215.4 40.9 5.6e-64 215.4 40.9 2.6 3 0 0 3 3 3 2 Centrosome localisation domain of Cep57 Cep57_MT_bd PF06657.13 EMC83096.1 - 1.7e-18 66.8 3.7 1.7e-18 66.8 3.7 4.7 2 1 1 4 4 4 1 Centrosome microtubule-binding domain of Cep57 CENP-F_leu_zip PF10473.9 EMC83096.1 - 3.8 7.5 65.7 4 7.5 9.2 3.4 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MGC-24 PF05283.11 EMC83097.1 - 4.9e-31 108.0 15.4 1.3e-30 106.7 15.4 1.6 1 1 0 1 1 1 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF4366 PF14283.6 EMC83097.1 - 0.018 15.1 0.0 0.022 14.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Alpha_GJ PF03229.13 EMC83097.1 - 0.033 14.7 8.3 0.046 14.3 8.3 1.3 1 0 0 1 1 1 0 Alphavirus glycoprotein J Mucin PF01456.17 EMC83097.1 - 0.19 11.7 27.1 0.23 11.5 27.1 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein zf-H2C2_2 PF13465.6 EMC83098.1 - 6.6e-52 171.7 47.9 5.2e-09 36.1 0.9 9.4 9 0 0 9 9 9 8 Zinc-finger double domain zf-C2H2 PF00096.26 EMC83098.1 - 6.4e-39 130.3 61.8 3.7e-07 30.2 0.4 8.6 8 0 0 8 8 8 8 Zinc finger, C2H2 type BTB PF00651.31 EMC83098.1 - 5e-27 94.3 0.2 1.1e-26 93.2 0.2 1.6 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.6 EMC83098.1 - 5.6e-27 92.1 63.7 0.0004 21.0 0.4 8.9 9 0 0 9 9 8 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC83098.1 - 2.9e-14 52.9 35.7 0.15 12.4 0.0 9.1 9 0 0 9 9 9 7 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC83098.1 - 2.9e-10 40.2 46.2 0.00066 20.0 0.3 8.8 8 0 0 8 8 8 6 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EMC83098.1 - 1.6e-06 28.0 51.4 0.0022 18.0 0.4 8.6 8 1 0 8 8 8 4 C2H2-type zinc finger zf_UBZ PF18439.1 EMC83098.1 - 4.2e-06 26.2 27.4 0.19 11.3 0.1 8.2 8 0 0 8 8 8 3 Ubiquitin-Binding Zinc Finger zf-Di19 PF05605.12 EMC83098.1 - 2.2e-05 24.7 28.3 0.029 14.7 0.6 4.9 3 2 1 5 5 5 3 Drought induced 19 protein (Di19), zinc-binding zf-C2HE PF16278.5 EMC83098.1 - 0.0095 16.4 43.2 0.39 11.2 5.3 7.6 2 2 3 5 5 5 2 C2HE / C2H2 / C2HC zinc-binding finger Zn-ribbon_8 PF09723.10 EMC83098.1 - 0.01 15.9 33.6 0.28 11.3 1.7 6.2 3 2 4 7 7 7 0 Zinc ribbon domain zinc_ribbon_15 PF17032.5 EMC83098.1 - 0.011 16.5 26.7 0.12 13.1 1.3 5.1 1 1 4 5 5 5 0 zinc-ribbon family zf-C2H2_9 PF16293.5 EMC83098.1 - 0.024 14.5 5.5 2.7 7.9 0.1 4.5 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) C1_1 PF00130.22 EMC83098.1 - 0.035 14.0 26.6 2.1 8.3 3.8 5.5 2 1 3 5 5 5 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2HC_2 PF13913.6 EMC83098.1 - 0.075 13.0 0.1 0.075 13.0 0.1 5.0 5 0 0 5 5 5 0 zinc-finger of a C2HC-type DUF2180 PF09947.9 EMC83098.1 - 0.081 12.9 11.5 6.3 6.8 0.2 4.8 2 2 2 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2180) HypA PF01155.19 EMC83098.1 - 0.089 12.8 25.9 20 5.2 4.0 5.4 2 1 1 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA AT_hook PF02178.19 EMC83098.1 - 0.24 11.4 6.4 0.76 9.8 6.4 1.8 1 0 0 1 1 1 0 AT hook motif zf-MYST PF17772.1 EMC83098.1 - 0.37 10.4 8.7 0.73 9.5 0.4 4.2 2 2 2 4 4 4 0 MYST family zinc finger domain zf-AN1 PF01428.16 EMC83098.1 - 0.84 9.9 38.4 0.69 10.1 1.0 7.9 7 1 1 8 8 8 0 AN1-like Zinc finger zf-LYAR PF08790.11 EMC83098.1 - 1.5 8.8 36.3 3 7.8 1.0 8.1 8 0 0 8 8 8 0 LYAR-type C2HC zinc finger BolA PF01722.18 EMC83098.1 - 2.2 8.6 8.5 2.2 8.6 0.1 4.1 2 2 2 4 4 4 0 BolA-like protein zf-FCS PF06467.14 EMC83098.1 - 2.2 8.3 26.6 2.7 8.0 0.2 6.3 5 2 1 6 6 6 0 MYM-type Zinc finger with FCS sequence motif DZR PF12773.7 EMC83098.1 - 2.8 8.0 31.8 1.4e+02 2.6 12.7 4.9 1 1 1 2 2 1 0 Double zinc ribbon FYVE PF01363.21 EMC83098.1 - 4.1 7.6 37.7 9.7 6.4 3.6 4.8 1 1 3 4 4 4 0 FYVE zinc finger ADK PF00406.22 EMC83099.1 - 6.3e-18 65.3 0.0 1.1e-17 64.6 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EMC83099.1 - 3.8e-14 53.3 0.0 8.3e-14 52.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain FAP206 PF12018.8 EMC83099.1 - 1.5e-11 44.4 1.0 1.2e-06 28.3 0.0 3.2 3 0 0 3 3 3 2 Domain of unknown function YHS PF04945.13 EMC83099.1 - 5.5e-11 42.4 1.8 0.016 15.3 0.0 3.7 3 0 0 3 3 3 3 YHS domain AAA_18 PF13238.6 EMC83099.1 - 0.00083 19.9 0.0 0.0073 16.8 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_24 PF13479.6 EMC83099.1 - 0.0077 16.0 0.1 0.013 15.3 0.1 1.3 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 EMC83099.1 - 0.0082 15.6 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein Cytidylate_kin PF02224.18 EMC83099.1 - 0.0084 15.9 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 Cytidylate kinase AAA_28 PF13521.6 EMC83099.1 - 0.013 15.7 0.0 0.044 14.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EMC83099.1 - 0.017 15.3 0.0 0.052 13.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 EMC83099.1 - 0.058 12.5 0.0 0.069 12.3 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_22 PF13401.6 EMC83099.1 - 0.1 12.9 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EMC83100.1 - 1.6e-12 48.0 0.0 6.3e-06 26.6 0.0 2.3 1 1 0 2 2 2 2 AAA domain ADK PF00406.22 EMC83100.1 - 7.7e-12 45.6 0.1 2.3e-07 31.1 0.0 2.2 2 0 0 2 2 2 2 Adenylate kinase AAA_18 PF13238.6 EMC83100.1 - 1.1e-06 29.2 0.2 4.8e-06 27.1 0.2 2.1 1 1 0 1 1 1 1 AAA domain FAP206 PF12018.8 EMC83100.1 - 4.7e-05 23.0 1.0 0.00015 21.4 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function AAA_28 PF13521.6 EMC83100.1 - 7.7e-05 23.0 0.1 0.00028 21.2 0.0 2.0 2 1 0 2 2 2 1 AAA domain YHS PF04945.13 EMC83100.1 - 0.00012 22.1 6.1 0.0018 18.3 5.7 2.8 2 1 1 3 3 3 1 YHS domain AAA PF00004.29 EMC83100.1 - 0.00036 21.0 0.0 0.00058 20.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EMC83100.1 - 0.002 18.3 0.0 0.0071 16.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 EMC83100.1 - 0.003 17.6 0.0 0.0057 16.6 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 EMC83100.1 - 0.0034 17.1 0.6 0.005 16.6 0.0 1.6 2 0 0 2 2 2 1 AAA domain G-alpha PF00503.20 EMC83100.1 - 0.0087 15.3 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 G-protein alpha subunit PhoH PF02562.16 EMC83100.1 - 0.011 15.2 0.0 0.016 14.7 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 EMC83100.1 - 0.016 15.7 0.1 0.034 14.7 0.1 1.7 1 1 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 EMC83100.1 - 0.019 15.3 0.0 0.063 13.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain SKI PF01202.22 EMC83100.1 - 0.021 15.0 0.1 0.059 13.5 0.0 1.8 2 0 0 2 2 1 0 Shikimate kinase NB-ARC PF00931.22 EMC83100.1 - 0.023 13.9 0.0 0.042 13.0 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain dNK PF01712.19 EMC83100.1 - 0.036 13.9 0.0 0.39 10.5 0.0 2.3 2 0 0 2 2 2 0 Deoxynucleoside kinase NACHT PF05729.12 EMC83100.1 - 0.048 13.6 0.0 0.49 10.3 0.0 2.1 2 0 0 2 2 2 0 NACHT domain RNA_helicase PF00910.22 EMC83100.1 - 0.065 13.6 0.1 0.35 11.3 0.0 2.2 2 0 0 2 2 2 0 RNA helicase ATPase_2 PF01637.18 EMC83100.1 - 0.085 12.8 0.1 0.085 12.8 0.1 1.7 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 EMC83100.1 - 0.14 12.2 0.7 0.42 10.7 0.1 2.3 2 1 0 2 2 2 0 AAA domain UPF0547 PF10571.9 EMC83101.1 - 0.0041 17.2 10.0 0.029 14.5 10.0 2.6 1 0 0 1 1 1 1 Uncharacterised protein family UPF0547 7tm_1 PF00001.21 EMC83102.1 - 1.1e-11 44.6 2.0 1.2e-11 44.4 2.0 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC83102.1 - 1.1e-10 41.7 2.5 1.2e-10 41.6 2.5 1.0 1 0 0 1 1 1 1 Olfactory receptor MIF4G PF02854.19 EMC83103.1 - 5.7e-18 65.3 2.7 9e-18 64.7 2.7 1.2 1 0 0 1 1 1 1 MIF4G domain Sec34 PF04136.15 EMC83103.1 - 0.018 14.9 2.5 0.033 14.1 2.5 1.3 1 0 0 1 1 1 0 Sec34-like family Menin PF05053.13 EMC83103.1 - 0.033 12.6 3.2 0.051 11.9 3.2 1.2 1 0 0 1 1 1 0 Menin MH1 PF03165.16 EMC83104.1 - 1.2e-19 70.5 7.0 1.5e-19 70.1 7.0 1.1 1 0 0 1 1 1 1 MH1 domain Dymeclin PF09742.9 EMC83105.1 - 2.1e-178 594.7 13.4 2.4e-178 594.5 13.4 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Hid1 PF12722.7 EMC83105.1 - 4.4e-10 38.4 20.5 3.6e-07 28.7 6.9 3.5 3 1 1 4 4 4 3 High-temperature-induced dauer-formation protein TLV_coat PF00429.19 EMC83106.1 - 9e-103 344.9 0.2 1e-102 344.6 0.2 1.0 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) PhnA_Zn_Ribbon PF08274.12 EMC83106.1 - 0.018 15.0 0.0 0.053 13.5 0.0 1.8 1 0 0 1 1 1 0 PhnA Zinc-Ribbon DUF4512 PF14975.6 EMC83107.1 - 6.8e-19 68.4 1.5 7.3e-19 68.4 1.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4512) Ribosomal_L22 PF00237.19 EMC83108.1 - 4.1e-49 165.1 0.1 6.1e-49 164.5 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Lipase PF00151.19 EMC83109.1 - 6.6e-78 262.4 0.0 1.8e-77 260.9 0.0 1.6 2 0 0 2 2 2 1 Lipase PLAT PF01477.23 EMC83109.1 - 2.7e-19 69.9 0.1 6.2e-19 68.7 0.1 1.6 1 0 0 1 1 1 1 PLAT/LH2 domain Thiolase_N PF00108.23 EMC83110.1 - 3.2e-91 305.3 0.1 5.4e-91 304.5 0.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EMC83110.1 - 2.9e-52 175.5 0.3 6e-52 174.5 0.3 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EMC83110.1 - 6.9e-05 22.5 0.6 0.0059 16.2 0.3 2.5 2 0 0 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.10 EMC83110.1 - 0.13 12.5 0.0 0.34 11.1 0.0 1.7 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal zf-C4H2 PF10146.9 EMC83111.1 - 6.5e-79 265.2 21.4 7.4e-79 265.0 21.4 1.0 1 0 0 1 1 1 1 Zinc finger-containing protein DZR PF12773.7 EMC83111.1 - 0.0079 16.2 1.1 0.016 15.2 1.1 1.5 1 0 0 1 1 1 1 Double zinc ribbon Sec20 PF03908.13 EMC83111.1 - 0.013 15.4 4.3 0.015 15.2 0.2 2.2 1 1 1 2 2 2 0 Sec20 CENP-O PF09496.10 EMC83111.1 - 0.051 13.6 4.5 0.085 12.8 3.8 1.7 1 1 1 2 2 2 0 Cenp-O kinetochore centromere component Lipoprotein_7 PF01540.16 EMC83111.1 - 0.058 12.7 5.1 0.09 12.0 5.1 1.3 1 0 0 1 1 1 0 Adhesin lipoprotein zf-C3HC4_3 PF13920.6 EMC83111.1 - 0.065 13.1 4.2 0.12 12.3 4.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-P11 PF03854.14 EMC83111.1 - 0.087 12.5 2.2 0.17 11.5 2.2 1.4 1 0 0 1 1 1 0 P-11 zinc finger zf-RING_4 PF14570.6 EMC83111.1 - 0.11 12.3 2.7 0.24 11.2 2.7 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain BLOC1_2 PF10046.9 EMC83111.1 - 0.13 12.6 9.4 5.7 7.3 0.9 2.6 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cytochrom_C_2 PF01322.20 EMC83111.1 - 0.19 12.6 0.4 0.19 12.6 0.4 2.3 2 1 0 2 2 2 0 Cytochrome C' Sec34 PF04136.15 EMC83111.1 - 0.21 11.5 8.2 0.21 11.4 2.2 2.2 1 1 1 2 2 2 0 Sec34-like family DUF1664 PF07889.12 EMC83111.1 - 0.59 10.2 5.3 2 8.4 5.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF16 PF01519.16 EMC83111.1 - 0.73 10.3 9.3 0.051 14.1 1.5 2.5 1 1 2 3 3 3 0 Protein of unknown function DUF16 Tup_N PF08581.10 EMC83111.1 - 1 9.7 13.9 0.86 10.0 9.8 2.8 1 1 1 2 2 2 0 Tup N-terminal Fez1 PF06818.15 EMC83111.1 - 1.1 9.6 17.6 2.3 8.6 17.6 1.5 1 1 0 1 1 1 0 Fez1 DUF3365 PF11845.8 EMC83111.1 - 2 8.7 6.8 1.8 8.9 5.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3365) YabA PF06156.13 EMC83111.1 - 2.8 8.6 16.3 0.51 11.0 2.4 2.5 1 1 1 2 2 2 0 Initiation control protein YabA V_ATPase_I PF01496.19 EMC83111.1 - 4.2 5.2 7.9 5.3 4.8 7.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family WAC_Acf1_DNA_bd PF10537.9 EMC83111.1 - 5.5 7.6 7.8 2.9 8.4 1.5 2.4 1 1 0 2 2 2 0 ATP-utilising chromatin assembly and remodelling N-terminal TMF_TATA_bd PF12325.8 EMC83111.1 - 6.8 6.9 18.4 7.9 6.7 9.5 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF3450 PF11932.8 EMC83111.1 - 6.8 5.9 18.6 0.45 9.8 5.8 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) FUSC PF04632.12 EMC83111.1 - 7.7 4.9 9.8 15 4.0 9.6 1.4 1 1 0 1 1 1 0 Fusaric acid resistance protein family RNase_Zc3h12a PF11977.8 EMC83112.1 - 3.3e-65 218.6 0.0 5.1e-65 218.0 0.0 1.3 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain UBA_6 PF18039.1 EMC83112.1 - 1.8e-18 66.1 0.2 3.5e-18 65.2 0.2 1.5 1 0 0 1 1 1 1 UBA-like domain Regnase_1_C PF18561.1 EMC83112.1 - 3.9e-16 58.5 0.1 8.8e-16 57.4 0.1 1.5 1 0 0 1 1 1 1 Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain zf-CCCH_4 PF18044.1 EMC83112.1 - 0.00023 20.9 7.0 0.00059 19.6 7.0 1.8 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 EMC83112.1 - 2.2 8.8 9.6 8.9 7.0 9.6 2.2 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger DUF2890 PF11081.8 EMC83113.1 - 0.24 11.5 1.3 0.37 10.9 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) Las1 PF04031.13 EMC83114.1 - 4.2e-32 111.4 0.0 5.6e-32 111.0 0.0 1.2 1 0 0 1 1 1 1 Las1-like BTB_2 PF02214.22 EMC83115.1 - 2.5e-23 82.2 0.0 4.4e-23 81.5 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans PF00520.31 EMC83115.1 - 1.3e-21 77.0 20.4 2.2e-21 76.2 20.3 1.4 1 1 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 EMC83115.1 - 2.1e-10 40.4 8.0 2.1e-10 40.4 8.0 2.4 3 0 0 3 3 3 1 Ion channel BTB_3 PF16017.5 EMC83115.1 - 0.0023 18.0 0.0 0.0046 17.0 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain ATP1G1_PLM_MAT8 PF02038.16 EMC83115.1 - 0.22 11.0 5.3 0.087 12.3 0.6 2.4 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family CTD PF12815.7 EMC83116.1 - 1e-06 29.2 83.9 0.52 10.9 18.3 5.8 1 1 1 2 2 2 1 Spt5 C-terminal nonapeptide repeat binding Spt4 ERM PF00769.19 EMC83117.1 - 4.3e-72 242.9 71.4 4.3e-72 242.9 71.4 2.2 1 1 1 2 2 2 1 Ezrin/radixin/moesin family FERM_C PF09380.10 EMC83117.1 - 9.6e-28 96.4 0.0 3.6e-27 94.6 0.0 2.1 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 EMC83117.1 - 1.4e-27 96.4 0.3 1.4e-27 96.4 0.3 3.9 2 1 1 3 3 3 1 FERM central domain FERM_N PF09379.10 EMC83117.1 - 5.1e-15 55.2 0.5 6.3e-14 51.7 0.1 2.6 2 0 0 2 2 2 1 FERM N-terminal domain Filo_glycop PF01611.16 EMC83117.1 - 0.54 9.1 2.3 0.81 8.6 2.3 1.2 1 0 0 1 1 1 0 Filovirus glycoprotein Fer2 PF00111.27 EMC83118.1 - 2.6e-08 33.7 0.3 3.3e-08 33.4 0.3 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain V-set PF07686.17 EMC83120.1 - 1e-19 70.7 0.4 3e-13 49.9 0.1 3.1 2 1 1 3 3 3 3 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC83120.1 - 5.1e-16 59.0 0.1 5.4e-09 36.5 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 EMC83120.1 - 2.5e-13 50.1 0.3 1.7e-06 28.3 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC83120.1 - 2.2e-12 46.8 0.0 0.00011 22.2 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 EMC83120.1 - 1.5e-11 44.3 0.1 0.00026 21.1 0.1 2.7 2 1 0 2 2 2 2 Immunoglobulin domain Ig_6 PF18452.1 EMC83120.1 - 0.00098 18.6 0.0 0.25 10.9 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Izumo-Ig PF16706.5 EMC83120.1 - 0.0052 16.8 0.0 3.6 7.7 0.0 2.3 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain Ig_C17orf99 PF17736.1 EMC83120.1 - 0.069 13.2 0.0 6.9 6.8 0.1 2.5 2 1 0 2 2 2 0 C17orf99 Ig domain Ig_4 PF16680.5 EMC83120.1 - 0.071 13.4 0.0 1.7 9.0 0.0 2.4 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain V-set_CD47 PF08204.11 EMC83120.1 - 0.092 12.7 0.0 1 9.4 0.0 2.1 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain Cu-oxidase_2 PF07731.14 EMC83121.1 - 8.9e-28 96.7 14.7 2.2e-12 46.9 1.1 6.9 6 2 0 6 6 6 5 Multicopper oxidase Cu-oxidase_3 PF07732.15 EMC83121.1 - 3e-25 88.5 0.2 7.6e-08 32.4 0.0 5.8 6 0 0 6 6 6 3 Multicopper oxidase 7tm_1 PF00001.21 EMC83122.1 - 8.2e-48 163.0 23.1 2.5e-47 161.4 23.7 1.4 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC83122.1 - 1.1e-09 38.0 23.6 1.5e-09 37.6 23.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC83122.1 - 0.0013 18.6 15.0 0.0022 17.8 15.0 1.6 1 1 0 1 1 1 1 Olfactory receptor DUF2116 PF09889.9 EMC83122.1 - 4.2 7.4 7.7 0.79 9.8 0.3 3.2 4 0 0 4 4 4 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) 7tm_1 PF00001.21 EMC83124.1 - 3.8e-53 180.5 22.2 4.9e-53 180.1 22.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC83124.1 - 3.3e-15 56.2 20.8 4e-15 55.9 20.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC83124.1 - 8.2e-05 22.5 17.5 0.00013 21.9 17.5 1.4 1 1 0 1 1 1 1 Olfactory receptor Hormone_recep PF00104.30 EMC83125.1 - 2.6e-31 108.8 4.0 2.7e-31 108.8 2.6 1.6 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 EMC83125.1 - 1.5e-27 95.9 14.4 2.7e-27 95.0 14.4 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) E2F_TDP PF02319.20 EMC83125.1 - 0.07 13.2 0.1 0.28 11.3 0.0 2.0 2 0 0 2 2 2 0 E2F/DP family winged-helix DNA-binding domain Yip1 PF04893.17 EMC83126.1 - 5.8e-19 68.5 15.0 7e-19 68.2 13.5 1.7 1 1 0 1 1 1 1 Yip1 domain START PF01852.19 EMC83127.1 - 1.5e-41 142.2 0.2 3e-41 141.2 0.2 1.5 1 0 0 1 1 1 1 START domain RhoGAP PF00620.27 EMC83127.1 - 3.2e-35 121.2 0.1 6.8e-35 120.1 0.1 1.4 1 0 0 1 1 1 1 RhoGAP domain Wound_ind PF08186.11 EMC83127.1 - 0.11 13.0 3.6 0.34 11.4 3.6 1.8 1 0 0 1 1 1 0 Wound-inducible basic protein family Ephrin PF00812.17 EMC83129.1 - 1.1e-24 86.9 0.1 1.8e-24 86.3 0.1 1.3 1 0 0 1 1 1 1 Ephrin Syndecan PF01034.20 EMC83129.1 - 5.2 7.1 7.1 7.7 6.5 7.1 1.3 1 0 0 1 1 1 0 Syndecan domain SDA1 PF05285.12 EMC83130.1 - 1.6e-06 27.8 35.5 1.9e-06 27.6 35.5 1.1 1 0 0 1 1 1 1 SDA1 Caldesmon PF02029.15 EMC83130.1 - 0.00012 21.0 34.1 0.00014 20.7 34.1 1.1 1 0 0 1 1 1 1 Caldesmon Nop14 PF04147.12 EMC83130.1 - 0.00049 18.5 44.4 0.00064 18.1 44.4 1.1 1 0 0 1 1 1 1 Nop14-like family Presenilin PF01080.17 EMC83130.1 - 0.002 17.0 19.6 0.0025 16.6 19.6 1.1 1 0 0 1 1 1 1 Presenilin MDM1 PF15501.6 EMC83130.1 - 0.0066 15.7 26.3 0.0081 15.4 26.3 1.2 1 0 0 1 1 1 1 Nuclear protein MDM1 Mpp10 PF04006.12 EMC83130.1 - 0.052 12.0 51.4 0.071 11.5 51.4 1.1 1 0 0 1 1 1 0 Mpp10 protein Hid1 PF12722.7 EMC83130.1 - 0.35 9.0 17.9 0.41 8.7 17.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MDM10 PF12519.8 EMC83130.1 - 0.44 9.4 12.8 0.58 9.0 12.8 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 LAP1C PF05609.12 EMC83130.1 - 0.6 9.1 20.8 0.75 8.8 20.8 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Otopetrin PF03189.13 EMC83130.1 - 0.95 8.2 2.6 1.2 7.8 2.6 1.3 1 0 0 1 1 1 0 Otopetrin Lin-8 PF03353.15 EMC83130.1 - 0.97 8.9 24.8 1.2 8.6 24.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist NPR3 PF03666.13 EMC83130.1 - 1.8 7.2 20.7 2.4 6.8 20.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 V_ATPase_I PF01496.19 EMC83130.1 - 2 6.2 19.3 2.7 5.8 19.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2151 PF10221.9 EMC83130.1 - 2.2 6.8 17.8 2.8 6.4 17.8 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator DUF966 PF06136.13 EMC83130.1 - 4.3 7.0 20.3 5.7 6.5 20.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) SLC12 PF03522.15 EMC83130.1 - 4.9 6.1 17.1 6.4 5.7 17.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Apt1 PF10351.9 EMC83130.1 - 5 5.9 13.5 6.1 5.6 13.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Collagen PF01391.18 EMC83132.1 - 1.2e-09 37.7 67.3 1.7e-07 30.9 34.0 2.6 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) TNF PF00229.18 EMC83132.1 - 3.6e-09 36.6 0.4 1.7e-08 34.4 0.4 1.9 1 1 0 1 1 1 1 TNF(Tumour Necrosis Factor) family LRR_8 PF13855.6 EMC83134.1 - 9.9e-62 204.6 56.5 1.5e-11 43.9 3.4 10.0 5 2 6 11 11 11 11 Leucine rich repeat LRR_4 PF12799.7 EMC83134.1 - 6.1e-46 153.6 52.4 6.4e-07 29.6 0.0 10.6 8 2 3 11 11 11 11 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC83134.1 - 1.3e-18 64.6 60.7 2 9.3 0.2 18.7 19 1 0 19 19 19 8 Leucine Rich Repeat LRR_9 PF14580.6 EMC83134.1 - 1.9e-11 43.8 10.0 0.00014 21.4 0.3 6.6 4 3 2 7 7 7 2 Leucine-rich repeat LRR_6 PF13516.6 EMC83134.1 - 7.1e-07 28.8 65.5 5 7.4 0.4 17.6 19 0 0 19 19 19 6 Leucine Rich repeat LRR_5 PF13306.6 EMC83134.1 - 4.7e-05 23.3 0.0 0.5 10.3 0.0 3.8 4 1 0 4 4 4 2 BspA type Leucine rich repeat region (6 copies) wnt PF00110.19 EMC83135.1 - 1.2e-112 376.5 7.2 1.4e-112 376.3 7.2 1.0 1 0 0 1 1 1 1 wnt family TAP42 PF04177.12 EMC83136.1 - 1.1e-73 248.2 0.0 1.2e-73 248.0 0.0 1.0 1 0 0 1 1 1 1 TAP42-like family IATP PF04568.12 EMC83136.1 - 0.16 12.4 0.0 0.16 12.4 0.0 2.2 3 0 0 3 3 3 0 Mitochondrial ATPase inhibitor, IATP Ribosomal_60s PF00428.19 EMC83136.1 - 4 8.1 8.5 0.25 11.9 0.4 2.6 2 1 0 2 2 2 0 60s Acidic ribosomal protein DAGAT PF03982.13 EMC83137.1 - 1.5e-116 388.4 0.0 1.9e-116 388.1 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase 7tm_1 PF00001.21 EMC83138.1 - 7e-47 159.9 24.7 8.1e-47 159.7 24.7 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Serpentine_r_xa PF03383.15 EMC83138.1 - 0.0034 17.4 4.0 0.0034 17.4 4.0 2.3 1 1 1 2 2 2 1 Caenorhabditis serpentine receptor-like protein, class xa DUF898 PF05987.13 EMC83138.1 - 0.013 14.6 0.8 0.013 14.6 0.8 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF898) Arrestin_N PF00339.29 EMC83140.1 - 3.5e-42 143.9 0.1 4.8e-38 130.5 0.0 2.2 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EMC83140.1 - 3.9e-26 92.1 1.0 6.6e-26 91.4 1.0 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain BatD PF13584.6 EMC83140.1 - 0.00076 18.4 0.1 0.001 18.0 0.1 1.1 1 0 0 1 1 1 1 Oxygen tolerance Glyco_hydro_66 PF13199.6 EMC83140.1 - 0.1 11.2 0.5 0.13 10.9 0.5 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 66 CBM49 PF09478.10 EMC83140.1 - 0.2 12.0 1.2 0.35 11.2 1.2 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain CBM49 Ras PF00071.22 EMC83141.1 - 6.4e-28 97.4 0.1 6.9e-28 97.3 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC83141.1 - 1.2e-24 86.9 0.1 1.2e-24 86.8 0.1 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC83141.1 - 6.1e-07 29.1 0.1 6.5e-07 29.0 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EMC83141.1 - 0.00027 20.4 0.0 0.00032 20.2 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EMC83141.1 - 0.031 14.3 0.0 0.035 14.2 0.0 1.1 1 0 0 1 1 1 0 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMC83141.1 - 0.06 12.7 0.0 0.063 12.6 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EMC83141.1 - 0.069 12.7 0.0 0.14 11.6 0.0 1.5 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain RVT_1 PF00078.27 EMC83142.1 - 0.077 12.5 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Kinesin PF00225.23 EMC83143.1 - 1.7e-115 385.5 0.0 1.7e-115 385.5 0.0 3.2 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EMC83143.1 - 7.3e-24 84.4 0.0 7.3e-24 84.4 0.0 4.0 5 1 0 5 5 5 1 Microtubule binding DUF3800 PF12686.7 EMC83143.1 - 0.021 15.4 1.6 39 4.9 1.6 4.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) TCR PF03638.15 EMC83143.1 - 1.6 9.1 16.1 3.2 8.1 16.1 1.5 1 0 0 1 1 1 0 Tesmin/TSO1-like CXC domain, cysteine-rich domain Collagen PF01391.18 EMC83144.1 - 5.9e-17 61.2 33.2 4.6e-08 32.7 9.1 3.1 1 1 2 3 3 3 3 Collagen triple helix repeat (20 copies) SLAIN PF15301.6 EMC83146.1 - 2e-157 524.9 31.6 1.1e-140 469.8 26.2 2.0 1 1 1 2 2 2 2 SLAIN motif-containing family 7tm_1 PF00001.21 EMC83147.1 - 5.3e-40 137.4 10.3 8.7e-40 136.7 10.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC83147.1 - 6.5e-10 38.8 11.3 1.6e-09 37.5 11.3 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC83147.1 - 2.6e-07 30.5 4.7 2.6e-07 30.5 4.7 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC83147.1 - 0.0019 18.0 4.0 0.003 17.3 3.8 1.7 1 1 0 1 1 1 1 Olfactory receptor PHO4 PF01384.20 EMC83147.1 - 0.071 12.2 1.2 0.1 11.7 1.2 1.3 1 0 0 1 1 1 0 Phosphate transporter family Yae1_N PF09811.9 EMC83148.1 - 3e-07 30.0 23.9 1.3 8.8 23.9 2.9 1 1 0 1 1 1 1 Essential protein Yae1, N terminal BRCA-2_OB3 PF09104.10 EMC83149.1 - 0.073 12.7 1.1 0.16 11.6 1.1 1.6 1 0 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 bZIP_1 PF00170.21 EMC83149.1 - 0.11 12.6 12.8 0.46 10.6 1.4 2.5 2 0 0 2 2 2 0 bZIP transcription factor TSC22 PF01166.18 EMC83149.1 - 0.18 12.2 10.3 0.21 11.9 2.4 3.2 2 1 1 3 3 3 0 TSC-22/dip/bun family PspA_IM30 PF04012.12 EMC83149.1 - 0.48 10.0 13.0 1 8.9 13.0 1.5 1 1 0 1 1 1 0 PspA/IM30 family DUF641 PF04859.12 EMC83149.1 - 0.53 10.6 7.1 1.4 9.2 7.1 1.7 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) HALZ PF02183.18 EMC83149.1 - 0.66 10.2 8.6 0.077 13.2 3.0 2.3 2 0 0 2 2 2 0 Homeobox associated leucine zipper V_ATPase_I PF01496.19 EMC83149.1 - 0.75 7.6 4.1 0.96 7.3 4.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ZapB PF06005.12 EMC83149.1 - 0.91 10.0 15.1 3.1 8.3 12.4 2.6 1 1 1 2 2 2 0 Cell division protein ZapB Spc7 PF08317.11 EMC83149.1 - 1.5 7.6 12.0 2.6 6.8 12.0 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein YabA PF06156.13 EMC83149.1 - 2 9.1 11.5 1.8 9.3 2.3 2.8 1 1 1 2 2 2 0 Initiation control protein YabA PRKG1_interact PF15898.5 EMC83149.1 - 2.9 8.9 15.7 2.2 9.3 1.5 3.1 3 0 0 3 3 2 0 cGMP-dependent protein kinase interacting domain TMF_TATA_bd PF12325.8 EMC83149.1 - 3.7 7.8 12.8 0.59 10.4 5.3 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 EMC83149.1 - 6.8 6.8 20.2 0.058 13.4 3.0 3.5 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding TMPIT PF07851.13 EMC83149.1 - 8.6 5.5 5.6 12 5.0 5.6 1.3 1 0 0 1 1 1 0 TMPIT-like protein Yae1_N PF09811.9 EMC83151.1 - 0.0021 17.7 0.3 91 2.9 0.0 5.3 4 0 0 4 4 4 4 Essential protein Yae1, N terminal BLUF PF04940.12 EMC83153.1 - 0.019 15.1 0.0 0.048 13.8 0.0 1.7 1 1 0 1 1 1 0 Sensors of blue-light using FAD SSF PF00474.17 EMC83154.1 - 5.9e-24 84.7 0.1 6.1e-24 84.6 0.1 1.0 1 0 0 1 1 1 1 Sodium:solute symporter family SSF PF00474.17 EMC83155.1 - 1.1e-77 261.6 12.6 1.4e-77 261.3 12.6 1.0 1 0 0 1 1 1 1 Sodium:solute symporter family Spore_permease PF03845.13 EMC83155.1 - 0.0024 16.8 12.3 0.0041 16.0 12.3 1.3 1 0 0 1 1 1 1 Spore germination protein IBV_3C PF03620.13 EMC83155.1 - 0.33 11.4 4.5 0.11 13.0 1.0 1.9 1 1 1 2 2 2 0 IBV 3C protein DUF2070 PF09843.9 EMC83155.1 - 1.1 7.4 11.0 1.4 7.1 11.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) FH2 PF02181.23 EMC83156.1 - 4.8e-60 203.6 5.6 5.4e-60 203.5 5.6 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain Serine_rich PF08824.10 EMC83156.1 - 0.013 15.5 1.0 0.64 10.0 0.0 2.8 3 0 0 3 3 3 0 Serine rich protein interaction domain RMI1_N PF08585.12 EMC83156.1 - 0.026 14.3 0.1 0.035 13.9 0.1 1.2 1 0 0 1 1 1 0 RecQ mediated genome instability protein DNA_pack_N PF02500.15 EMC83156.1 - 0.27 11.0 3.1 0.21 11.4 0.2 2.0 1 1 0 2 2 2 0 Probable DNA packing protein, N-terminus DHHC PF01529.20 EMC83157.1 - 3.4e-31 108.1 9.6 3.4e-31 108.1 9.6 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase zf-C2H2 PF00096.26 EMC83158.1 - 1.7e-40 135.2 68.8 6e-05 23.3 3.2 10.4 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC83158.1 - 8.1e-35 116.5 66.6 0.0008 20.0 2.0 10.5 10 0 0 10 10 10 10 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC83158.1 - 3.1e-34 115.9 76.2 4.4e-08 33.2 1.7 10.4 11 0 0 11 11 10 8 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EMC83158.1 - 1.6e-22 79.2 31.5 0.00025 21.3 0.3 10.4 10 0 0 10 10 10 7 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 EMC83158.1 - 3.8e-09 36.2 38.2 0.001 18.8 0.1 9.2 10 0 0 10 10 10 4 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 EMC83158.1 - 1.6e-08 34.4 68.0 0.076 13.0 1.1 10.1 10 0 0 10 10 10 6 C2H2-type zinc finger zf-C2HC_2 PF13913.6 EMC83158.1 - 2.9e-05 23.8 37.7 0.091 12.7 0.3 8.4 8 0 0 8 8 8 3 zinc-finger of a C2HC-type Zn-ribbon_8 PF09723.10 EMC83158.1 - 5.2e-05 23.3 48.2 0.043 13.9 3.3 8.5 6 3 3 9 9 9 4 Zinc ribbon domain zf-C2H2_8 PF15909.5 EMC83158.1 - 0.00045 20.5 34.8 0.097 13.0 2.1 6.0 3 2 3 6 6 6 4 C2H2-type zinc ribbon zinc_ribbon_15 PF17032.5 EMC83158.1 - 0.00098 19.8 30.3 0.45 11.3 0.4 5.7 4 2 2 6 6 6 3 zinc-ribbon family zf-met PF12874.7 EMC83158.1 - 0.0012 19.2 0.6 0.0012 19.2 0.6 8.5 9 0 0 9 9 9 2 Zinc-finger of C2H2 type zf_UBZ PF18439.1 EMC83158.1 - 0.0013 18.2 38.0 0.39 10.3 0.3 9.5 10 0 0 10 10 10 4 Ubiquitin-Binding Zinc Finger zf-C2H2_2 PF12756.7 EMC83158.1 - 0.0018 18.6 42.2 0.29 11.5 0.1 8.9 3 2 6 9 9 9 2 C2H2 type zinc-finger (2 copies) DUF3268 PF11672.8 EMC83158.1 - 0.0024 18.2 23.6 0.089 13.1 2.3 4.5 3 2 1 4 4 4 3 zinc-finger-containing domain Zn_Tnp_IS1595 PF12760.7 EMC83158.1 - 0.0062 16.5 0.8 0.0062 16.5 0.8 7.1 6 2 0 6 6 5 2 Transposase zinc-ribbon domain Zn-C2H2_12 PF18112.1 EMC83158.1 - 0.012 16.1 9.3 2.3 8.7 0.1 4.8 4 0 0 4 4 4 0 Autophagy receptor zinc finger-C2H2 domain zinc_ribbon_9 PF14369.6 EMC83158.1 - 0.022 15.0 19.9 2.7 8.3 0.0 7.3 7 0 0 7 7 7 0 zinc-ribbon XPA_N PF01286.18 EMC83158.1 - 0.023 14.7 0.3 0.023 14.7 0.3 7.6 10 0 0 10 10 10 0 XPA protein N-terminal DZR PF12773.7 EMC83158.1 - 0.082 12.9 38.6 5.6 7.1 5.0 6.1 3 2 1 4 4 4 0 Double zinc ribbon zf-MYST PF17772.1 EMC83158.1 - 0.32 10.6 19.5 3.3 7.4 0.1 5.6 6 0 0 6 6 6 0 MYST family zinc finger domain TerY_C PF15616.6 EMC83158.1 - 1.4 9.0 8.0 11 6.1 0.2 4.1 3 1 1 4 4 4 0 TerY-C metal binding domain zf-Di19 PF05605.12 EMC83158.1 - 1.8 8.9 41.4 0.18 12.1 1.6 6.9 3 2 3 7 7 7 0 Drought induced 19 protein (Di19), zinc-binding ADK_lid PF05191.14 EMC83158.1 - 3.8 7.6 34.0 1.8 8.6 1.3 6.7 4 2 3 7 7 6 0 Adenylate kinase, active site lid BRICHOS PF04089.14 EMC83159.1 - 3e-17 62.6 0.0 5.1e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 BRICHOS domain WD40 PF00400.32 EMC83160.1 - 2.2e-33 113.7 4.2 3.2e-05 24.6 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC83160.1 - 2.1e-11 43.9 0.4 0.00055 20.2 0.1 4.5 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Hira PF07569.11 EMC83160.1 - 0.0011 18.7 0.5 0.15 11.8 0.0 3.0 1 1 3 4 4 4 1 TUP1-like enhancer of split Ge1_WD40 PF16529.5 EMC83160.1 - 0.0022 17.0 0.1 1.2 8.0 0.0 3.4 1 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EMC83160.1 - 0.062 11.9 0.9 8.3 4.9 0.0 3.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 DUF2415 PF10313.9 EMC83160.1 - 0.08 12.9 0.1 5.9 6.9 0.0 2.7 2 0 0 2 2 2 0 Uncharacterised protein domain (DUF2415) Frtz PF11768.8 EMC83160.1 - 0.12 10.6 0.0 0.15 10.3 0.0 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Glyco_hydro_20 PF00728.22 EMC83162.1 - 4.4e-11 42.8 0.0 7.6e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain DUF1146 PF06612.11 EMC83162.1 - 0.06 13.4 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1146) WD40 PF00400.32 EMC83163.1 - 1.2e-31 108.3 21.8 4.6e-08 33.6 1.2 7.8 7 0 0 7 7 7 6 WD domain, G-beta repeat WD40_like PF17005.5 EMC83163.1 - 2e-08 33.9 0.7 3.8e-08 33.0 0.7 1.5 1 0 0 1 1 1 1 WD40-like domain zf-RING_UBOX PF13445.6 EMC83163.1 - 1.6e-06 28.0 8.4 9.3e-06 25.6 8.4 2.4 1 0 0 1 1 1 1 RING-type zinc-finger Sina PF03145.16 EMC83163.1 - 1.1e-05 25.5 10.4 0.0024 17.9 0.7 2.4 1 1 1 2 2 2 2 Seven in absentia protein family zf-TRAF PF02176.18 EMC83163.1 - 2.8e-05 24.7 6.0 2.8e-05 24.7 6.0 2.7 3 1 0 3 3 2 1 TRAF-type zinc finger PKcGMP_CC PF16808.5 EMC83163.1 - 2.8e-05 23.9 0.9 0.0027 17.5 0.0 2.6 2 0 0 2 2 2 1 Coiled-coil N-terminus of cGMP-dependent protein kinase zf-C3HC4_2 PF13923.6 EMC83163.1 - 4.3e-05 23.3 14.3 4.3e-05 23.3 14.3 3.2 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC83163.1 - 4.6e-05 23.2 10.3 4.6e-05 23.2 10.3 3.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMC83163.1 - 0.00023 21.2 7.3 0.00023 21.2 7.3 2.4 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EMC83163.1 - 0.00058 19.7 11.4 0.00058 19.7 11.4 2.3 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Nup160 PF11715.8 EMC83163.1 - 0.00061 18.6 6.7 0.0028 16.4 0.5 3.6 3 1 1 4 4 4 1 Nucleoporin Nup120/160 zf-RING_5 PF14634.6 EMC83163.1 - 0.0087 16.0 13.3 0.0087 16.0 13.3 3.1 3 0 0 3 3 2 1 zinc-RING finger domain Nucleoporin_N PF08801.11 EMC83163.1 - 0.013 14.2 0.8 1.3 7.7 0.0 3.3 1 1 1 3 3 3 0 Nup133 N terminal like DUF4164 PF13747.6 EMC83163.1 - 0.016 15.5 2.8 0.029 14.6 2.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Tropomyosin_1 PF12718.7 EMC83163.1 - 0.033 14.3 3.1 0.054 13.7 3.1 1.3 1 0 0 1 1 1 0 Tropomyosin like DUF1664 PF07889.12 EMC83163.1 - 0.065 13.3 1.5 0.73 9.9 0.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF641 PF04859.12 EMC83163.1 - 0.076 13.3 0.2 0.15 12.4 0.2 1.5 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) PQQ_3 PF13570.6 EMC83163.1 - 0.083 13.4 2.4 21 5.8 0.1 4.8 5 1 0 5 5 4 0 PQQ-like domain Filament PF00038.21 EMC83163.1 - 0.092 12.3 3.3 0.14 11.7 3.3 1.2 1 0 0 1 1 1 0 Intermediate filament protein DUF16 PF01519.16 EMC83163.1 - 0.17 12.4 5.2 0.54 10.8 5.2 1.8 1 1 0 1 1 1 0 Protein of unknown function DUF16 DUF1640 PF07798.11 EMC83163.1 - 0.18 11.8 3.6 0.36 10.9 3.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) KxDL PF10241.9 EMC83163.1 - 0.32 11.3 3.9 0.33 11.3 1.9 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein SlyX PF04102.12 EMC83163.1 - 1.2 9.8 4.5 4.5 8.0 3.7 2.2 1 1 1 2 2 2 0 SlyX zf-Nse PF11789.8 EMC83163.1 - 2.8 7.8 11.8 2.3 8.1 7.3 2.7 2 1 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.5 EMC83163.1 - 8.6 6.6 18.4 1.8 8.8 10.4 2.8 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-RING_2 PF13639.6 EMC83163.1 - 9.6 6.6 20.4 0.71 10.2 13.3 2.9 2 0 0 2 2 2 0 Ring finger domain Ras PF00071.22 EMC83164.1 - 2.6e-59 199.4 0.2 3.1e-59 199.2 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC83164.1 - 2.2e-33 115.0 0.1 3.1e-33 114.5 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC83164.1 - 2.8e-14 52.9 0.1 3.4e-14 52.7 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EMC83164.1 - 7.4e-06 25.5 0.1 9.5e-06 25.1 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EMC83164.1 - 0.00013 21.9 0.5 0.19 11.6 0.1 2.3 2 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EMC83164.1 - 0.00021 21.3 0.0 0.00036 20.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EMC83164.1 - 0.00068 19.2 0.1 0.0031 17.1 0.1 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EMC83164.1 - 0.00071 19.2 0.2 0.0019 17.8 0.1 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EMC83164.1 - 0.0028 17.1 0.0 0.0033 16.9 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 EMC83164.1 - 0.005 17.2 0.1 0.011 16.1 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain Septin PF00735.18 EMC83164.1 - 0.018 14.3 0.1 0.051 12.8 0.1 1.7 1 1 0 1 1 1 0 Septin AsnC_trans_reg2 PF17805.1 EMC83164.1 - 0.024 14.8 0.2 0.069 13.3 0.1 1.7 2 0 0 2 2 2 0 AsnC-like ligand binding domain AAA_22 PF13401.6 EMC83164.1 - 0.045 14.0 0.1 0.13 12.5 0.1 2.1 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EMC83164.1 - 0.07 12.9 0.0 0.11 12.2 0.0 1.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.29 EMC83164.1 - 0.085 13.3 0.1 1 9.8 0.0 2.5 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EMC83164.1 - 0.093 12.6 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 NACHT domain HhH-GPD PF00730.25 EMC83166.1 - 5.1e-20 71.9 0.0 7.5e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EMC83166.1 - 1.8e-09 37.0 0.0 3.5e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 EMC83166.1 - 0.1 13.2 0.0 0.77 10.4 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix domain EBP50_C PF09007.11 EMC83167.1 - 2.2e-30 106.3 5.1 2.9e-20 73.6 2.3 2.9 2 1 1 3 3 3 2 EBP50, C-terminal PDZ_6 PF17820.1 EMC83167.1 - 2.9e-16 59.0 1.5 3.6e-16 58.7 0.1 1.8 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 EMC83167.1 - 1.7e-14 54.0 0.2 5.7e-14 52.2 0.0 2.0 3 0 0 3 3 3 1 PDZ domain PDZ_2 PF13180.6 EMC83167.1 - 7.9e-07 29.3 0.2 6.6e-06 26.4 0.0 2.3 2 1 0 2 2 2 1 PDZ domain GRASP55_65 PF04495.14 EMC83167.1 - 0.11 12.8 0.0 0.23 11.8 0.0 1.5 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain Peptidase_C54 PF03416.19 EMC83168.1 - 2.6e-102 342.0 0.0 3.1e-102 341.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 Ank_5 PF13857.6 EMC83169.1 - 1.6e-40 136.6 9.5 5.6e-14 52.0 0.2 4.0 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC83169.1 - 7.7e-40 134.8 3.9 3.9e-13 49.6 0.0 4.0 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EMC83169.1 - 5.5e-34 115.1 4.0 8.5e-08 32.3 0.1 4.2 4 0 0 4 4 4 4 Ankyrin repeat Ank_2 PF12796.7 EMC83169.1 - 9.7e-31 106.2 1.6 4.4e-16 59.2 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC83169.1 - 6.1e-30 99.9 1.2 8.4e-08 31.9 0.0 4.2 4 0 0 4 4 4 4 Ankyrin repeat AMNp_N PF10423.9 EMC83169.1 - 0.052 13.2 0.0 0.83 9.3 0.0 2.2 2 1 0 2 2 2 0 Bacterial AMP nucleoside phosphorylase N-terminus DUF249 PF03158.13 EMC83169.1 - 0.052 13.2 0.0 0.076 12.7 0.0 1.2 1 0 0 1 1 1 0 Multigene family 530 protein MafB19-deam PF14437.6 EMC83169.1 - 0.078 12.7 0.1 0.12 12.1 0.1 1.2 1 0 0 1 1 1 0 MafB19-like deaminase DUF4799 PF16056.5 EMC83169.1 - 0.078 12.1 0.0 0.14 11.3 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4799) V-set PF07686.17 EMC83170.1 - 1e-23 83.6 2.2 5.1e-21 74.9 0.2 2.6 2 1 1 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC83170.1 - 2.6e-19 69.6 1.0 9.1e-09 35.8 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC83170.1 - 1e-14 54.4 0.0 3.3e-06 27.1 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 EMC83170.1 - 3.2e-11 43.2 0.5 2.5e-06 27.6 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 EMC83170.1 - 8.2e-09 35.7 3.6 0.0024 18.2 0.1 3.0 2 1 0 2 2 2 2 Immunoglobulin domain Herpes_gE PF02480.16 EMC83170.1 - 0.0028 16.5 0.0 0.043 12.6 0.0 2.0 2 0 0 2 2 2 1 Alphaherpesvirus glycoprotein E Ig_C17orf99 PF17736.1 EMC83170.1 - 0.0062 16.6 0.1 0.33 11.0 0.0 2.8 3 0 0 3 3 3 1 C17orf99 Ig domain V-set_CD47 PF08204.11 EMC83170.1 - 0.0067 16.4 1.8 0.0074 16.3 0.1 1.9 2 0 0 2 2 2 1 CD47 immunoglobulin-like domain Shisa PF13908.6 EMC83170.1 - 0.01 16.1 0.1 0.022 15.0 0.1 1.5 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Syndecan PF01034.20 EMC83170.1 - 0.016 15.1 0.2 0.14 12.1 0.5 2.4 2 1 0 2 2 2 0 Syndecan domain Mucin15 PF15672.5 EMC83170.1 - 0.02 14.4 3.7 0.029 13.9 0.6 2.3 2 1 0 2 2 2 0 Cell-membrane associated Mucin15 EphA2_TM PF14575.6 EMC83170.1 - 0.037 14.9 0.0 0.066 14.1 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 EMC83170.1 - 0.041 13.8 0.5 0.12 12.3 0.1 1.9 1 1 1 2 2 2 0 TMEM154 protein family Vpu PF00558.19 EMC83170.1 - 0.046 13.5 0.2 0.083 12.7 0.2 1.3 1 0 0 1 1 1 0 Vpu protein MscL PF01741.18 EMC83170.1 - 0.077 13.3 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL Izumo-Ig PF16706.5 EMC83170.1 - 0.082 13.0 0.0 7 6.8 0.0 2.4 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain DUF5385 PF17359.2 EMC83170.1 - 0.084 12.4 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5385) C2 PF00168.30 EMC83171.1 - 2e-36 124.4 0.4 5.9e-20 71.5 0.1 2.2 2 0 0 2 2 2 2 C2 domain Ras PF00071.22 EMC83172.1 - 7.9e-22 77.6 0.0 8.5e-22 77.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC83172.1 - 1.8e-18 66.9 0.0 1.9e-18 66.8 0.0 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC83172.1 - 6.7e-05 22.4 0.0 7.1e-05 22.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC83172.1 - 0.00015 21.8 0.0 0.00017 21.6 0.0 1.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase TniB PF05621.11 EMC83172.1 - 0.15 11.4 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 Bacterial TniB protein Prefoldin PF02996.17 EMC83173.1 - 7.2e-37 126.0 0.3 1.2e-36 125.3 0.3 1.3 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 EMC83173.1 - 0.00042 20.2 3.8 0.079 12.9 0.0 2.3 2 1 0 2 2 2 2 Prefoldin subunit ATG19_autophagy PF12744.7 EMC83173.1 - 0.05 12.8 0.8 0.074 12.2 0.8 1.2 1 0 0 1 1 1 0 Autophagy protein Atg19, Atg8-binding DUF1664 PF07889.12 EMC83173.1 - 0.19 11.8 1.6 3 7.9 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) ANTH PF07651.16 EMC83174.1 - 1.2e-78 263.9 0.8 1.9e-78 263.3 0.8 1.3 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 EMC83174.1 - 7.4e-14 51.9 0.2 2e-13 50.5 0.2 1.7 1 0 0 1 1 1 1 ENTH domain STN1_2 PF09170.10 EMC83174.1 - 0.052 13.7 1.2 0.094 12.9 1.2 1.4 1 0 0 1 1 1 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 PH PF00169.29 EMC83175.1 - 3.2e-20 72.6 0.7 6.4e-20 71.6 0.7 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EMC83175.1 - 8e-05 23.0 4.2 0.00079 19.8 4.2 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 EMC83175.1 - 0.037 14.4 0.5 0.093 13.1 0.5 1.7 1 1 0 1 1 1 0 Pleckstrin homology domain Mcp5_PH PF12814.7 EMC83175.1 - 0.08 13.1 0.1 0.2 11.8 0.1 1.6 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology PH_3 PF14593.6 EMC83175.1 - 0.5 10.5 3.0 3.7 7.7 3.0 2.2 1 1 0 1 1 1 0 PH domain SNF2_N PF00176.23 EMC83176.1 - 4.4e-80 269.0 0.4 1e-79 267.8 0.4 1.5 1 1 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 EMC83176.1 - 2.2e-42 143.7 3.6 2.2e-42 143.7 3.6 2.7 3 0 0 3 3 3 1 SLIDE HAND PF09110.11 EMC83176.1 - 6.3e-30 104.2 2.2 6.3e-30 104.2 2.2 3.5 3 0 0 3 3 3 1 HAND Helicase_C PF00271.31 EMC83176.1 - 9.8e-22 77.4 0.0 1.2e-20 74.0 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC83176.1 - 8.2e-12 45.5 0.1 9.6e-11 42.0 0.0 2.9 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EMC83176.1 - 4.4e-07 29.8 0.0 2.2e-06 27.6 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase DBINO PF13892.6 EMC83176.1 - 2.1e-05 24.9 0.2 2.1e-05 24.9 0.2 5.2 5 0 0 5 5 5 1 DNA-binding domain HDA2-3 PF11496.8 EMC83176.1 - 2.3e-05 23.7 0.0 6.2e-05 22.3 0.0 1.7 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Myb_DNA-binding PF00249.31 EMC83176.1 - 2.9e-05 24.2 0.1 0.44 10.8 0.0 3.1 2 0 0 2 2 2 2 Myb-like DNA-binding domain ERCC3_RAD25_C PF16203.5 EMC83176.1 - 0.0021 17.3 0.0 0.0069 15.6 0.0 1.8 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase UBA_2 PF08587.11 EMC83176.1 - 0.15 12.2 1.7 0.8 9.9 0.0 3.1 3 0 0 3 3 3 0 Ubiquitin associated domain (UBA) CRM1_repeat_2 PF18784.1 EMC83177.1 - 0.0045 16.6 0.0 0.0069 16.0 0.0 1.3 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 cNMP_binding PF00027.29 EMC83177.1 - 0.092 12.8 0.1 0.19 11.8 0.0 1.5 2 0 0 2 2 2 0 Cyclic nucleotide-binding domain Ten_N PF06484.12 EMC83178.1 - 0.00038 20.5 2.1 0.00038 20.4 2.1 1.0 1 0 0 1 1 1 1 Teneurin Intracellular Region Histone_H2A_C PF16211.5 EMC83179.1 - 1.2e-20 72.9 1.8 2.2e-20 72.1 1.8 1.3 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EMC83179.1 - 5.8e-09 36.4 0.0 1.2e-08 35.3 0.0 1.6 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC83179.1 - 0.0096 16.2 0.0 0.016 15.5 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Pkinase PF00069.25 EMC83180.1 - 1.6e-61 208.0 0.0 2.3e-61 207.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC83180.1 - 3.8e-38 131.3 0.0 5.4e-38 130.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.24 EMC83180.1 - 1.5e-12 47.3 0.0 4.3e-12 45.8 0.0 1.9 1 0 0 1 1 1 1 PB1 domain Kinase-like PF14531.6 EMC83180.1 - 6.5e-05 22.4 0.0 0.0047 16.3 0.0 2.4 2 0 0 2 2 2 2 Kinase-like Seadorna_VP7 PF07387.11 EMC83180.1 - 0.049 12.7 0.2 1.9 7.5 0.0 2.1 2 0 0 2 2 2 0 Seadornavirus VP7 Thiolase_N PF00108.23 EMC83181.1 - 3.9e-80 268.9 1.2 6.5e-80 268.2 1.2 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EMC83181.1 - 1.7e-51 173.0 0.3 3.7e-51 171.9 0.3 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III_C PF08541.10 EMC83181.1 - 1.2e-05 25.3 0.0 3.9e-05 23.7 0.0 1.9 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 EMC83181.1 - 0.0003 20.6 1.6 0.074 12.9 0.1 2.8 2 0 0 2 2 2 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ketoacyl-synt PF00109.26 EMC83181.1 - 0.0052 16.4 1.3 0.024 14.2 0.3 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ASH PF15780.5 EMC83182.1 - 3.1e-15 56.2 3.6 0.11 12.7 0.0 8.6 10 0 0 10 10 10 4 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TMEM131_like PF12371.8 EMC83182.1 - 2.2e-06 27.8 0.3 0.0053 17.0 0.0 3.6 4 0 0 4 4 4 2 Transmembrane protein 131-like PapD-like PF14874.6 EMC83182.1 - 0.015 15.5 1.3 3.8 7.7 0.1 3.4 4 0 0 4 4 4 0 Flagellar-associated PapD-like MYCBPAP PF14646.6 EMC83182.1 - 0.031 13.2 0.7 3.1 6.7 0.0 3.0 3 0 0 3 3 3 0 MYCBP-associated protein family NIF PF03031.18 EMC83183.1 - 6.6e-53 178.7 0.0 8.6e-53 178.3 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase UQ_con PF00179.26 EMC83184.1 - 1.4e-43 147.9 0.0 1.5e-43 147.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EMC83184.1 - 0.00064 19.4 0.0 0.00079 19.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EMC83184.1 - 0.016 15.5 0.0 0.022 15.0 0.0 1.2 1 0 0 1 1 1 0 RWD domain UEV PF05743.13 EMC83184.1 - 0.14 12.1 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 UEV domain UQ_con PF00179.26 EMC83185.1 - 4.4e-47 159.3 0.0 6.7e-47 158.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EMC83185.1 - 0.0038 16.9 0.0 0.0057 16.4 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EMC83185.1 - 0.0042 17.4 0.0 0.0066 16.7 0.0 1.5 1 1 0 1 1 1 1 RWD domain SR-25 PF10500.9 EMC83185.1 - 0.083 12.5 10.0 0.11 12.1 10.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4603 PF15376.6 EMC83185.1 - 2.5 5.4 11.2 3.2 5.0 11.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) Ras PF00071.22 EMC83186.1 - 2.7e-26 92.1 0.3 3.1e-26 91.9 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC83186.1 - 2e-11 44.2 0.0 3.6e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC83186.1 - 6e-09 35.6 0.3 7.9e-09 35.2 0.3 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC83186.1 - 7e-06 26.1 0.0 9e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC83186.1 - 0.00055 19.5 1.1 0.12 11.9 1.2 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EMC83186.1 - 0.0017 18.3 0.5 0.12 12.3 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 EMC83186.1 - 0.015 15.3 0.4 0.19 11.8 0.4 2.6 1 1 0 1 1 1 0 Dynamin family AAA_14 PF13173.6 EMC83186.1 - 0.038 14.0 0.1 0.17 11.9 0.1 1.9 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 EMC83186.1 - 0.052 13.1 2.1 3.2 7.3 0.2 2.1 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PRORP PF16953.5 EMC83186.1 - 0.055 13.0 0.0 0.066 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein-only RNase P FeoB_N PF02421.18 EMC83186.1 - 0.055 13.0 0.1 0.14 11.7 0.1 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_24 PF13479.6 EMC83186.1 - 0.08 12.6 0.0 0.11 12.2 0.0 1.3 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EMC83186.1 - 0.18 12.1 1.0 1.3 9.3 0.1 2.2 1 1 0 2 2 2 0 AAA domain Ribosomal_L15e PF00827.17 EMC83187.1 - 4.7e-98 326.6 3.7 5.3e-98 326.4 3.7 1.0 1 0 0 1 1 1 1 Ribosomal L15 Hepatitis_core PF00906.20 EMC83187.1 - 2.5 7.6 7.9 0.14 11.7 0.3 2.0 2 0 0 2 2 2 0 Hepatitis core antigen zf-C4 PF00105.18 EMC83188.1 - 7.2e-31 106.5 15.9 7.2e-31 106.5 15.9 1.8 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 EMC83188.1 - 4e-25 88.6 0.3 1.1e-24 87.2 0.3 1.7 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor LpxD PF04613.14 EMC83188.1 - 0.038 13.8 0.0 0.076 12.8 0.0 1.5 1 0 0 1 1 1 0 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD zf-C4 PF00105.18 EMC83189.1 - 3.2e-30 104.4 15.9 6.8e-30 103.3 15.9 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 EMC83189.1 - 2.5e-17 63.1 0.1 8.4e-17 61.4 0.0 1.9 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 EMC83190.1 - 3.8e-34 117.0 16.3 4.4e-34 116.8 16.3 1.0 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 EMC83191.1 - 1.2e-13 51.2 0.0 1.2e-13 51.1 0.0 1.0 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor DNA_topoisoIV PF00521.20 EMC83192.1 - 1.5e-133 445.9 0.3 2.8e-133 444.9 0.0 1.6 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 EMC83192.1 - 2.4e-49 166.9 4.5 2.4e-49 166.9 4.5 2.5 2 0 0 2 2 2 1 C-terminal associated domain of TOPRIM DTHCT PF08070.11 EMC83192.1 - 2.3e-27 95.7 16.5 2.3e-27 95.7 16.5 6.5 4 1 2 6 6 6 1 DTHCT (NUC029) region DNA_gyraseB PF00204.25 EMC83192.1 - 2.1e-24 86.0 0.6 5.4e-24 84.6 0.6 1.7 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 EMC83192.1 - 2.1e-14 54.0 0.0 8.4e-14 52.0 0.0 2.2 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 EMC83192.1 - 3.4e-09 36.9 0.0 1.6e-08 34.7 0.0 2.2 2 0 0 2 2 2 1 Toprim domain PAW PF04721.17 EMC83193.1 - 2.5e-73 246.1 1.7 2.5e-73 246.1 1.7 1.6 2 0 0 2 2 2 1 PNGase C-terminal domain, mannose-binding module PAW PUB PF09409.10 EMC83193.1 - 6.3e-16 58.1 0.5 3e-15 55.9 0.0 2.4 2 0 0 2 2 2 1 PUB domain Transglut_core PF01841.19 EMC83193.1 - 5.8e-14 52.5 1.6 1.2e-13 51.4 0.9 2.0 2 0 0 2 2 2 1 Transglutaminase-like superfamily Rad4 PF03835.15 EMC83193.1 - 2.4e-11 43.5 0.6 4.5e-11 42.6 0.6 1.3 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain TSC22 PF01166.18 EMC83193.1 - 0.068 13.5 3.8 0.77 10.1 0.0 3.0 2 1 0 2 2 2 0 TSC-22/dip/bun family ketoacyl-synt PF00109.26 EMC83194.1 - 2.7e-56 191.0 4.6 4.6e-56 190.2 1.8 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EMC83194.1 - 6.2e-38 129.5 0.2 1.2e-37 128.6 0.2 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 EMC83194.1 - 6.1e-06 25.8 0.1 6.1e-05 22.5 0.1 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain KAsynt_C_assoc PF16197.5 EMC83194.1 - 0.17 12.3 0.0 0.44 11.0 0.0 1.6 1 0 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension LRR_8 PF13855.6 EMC83195.1 - 2.2e-17 62.5 3.3 1.7e-11 43.7 0.2 2.5 1 1 1 2 2 2 2 Leucine rich repeat LRRNT PF01462.18 EMC83195.1 - 6.2e-09 35.3 3.0 6.2e-09 35.3 3.0 2.1 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_4 PF12799.7 EMC83195.1 - 5e-08 33.1 8.5 2.5e-05 24.5 0.6 3.3 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC83195.1 - 2.7e-06 27.4 0.1 4.3e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 EMC83195.1 - 0.0003 20.6 2.2 0.2 11.8 0.0 3.4 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.33 EMC83195.1 - 0.00047 20.3 8.7 0.23 12.1 0.2 4.5 4 2 0 4 4 4 2 Leucine Rich Repeat HCO3_cotransp PF00955.21 EMC83196.1 - 4.1e-244 811.1 10.7 5.3e-244 810.7 10.7 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 EMC83196.1 - 9.9e-107 356.7 0.0 5.3e-106 354.3 0.0 2.1 1 1 0 1 1 1 1 Band 3 cytoplasmic domain Med13_C PF06333.12 EMC83196.1 - 1.7 7.8 5.3 13 4.9 3.7 2.1 1 1 1 2 2 2 0 Mediator complex subunit 13 C-terminal domain MFS_MOT1 PF16983.5 EMC83196.1 - 1.9 8.9 6.2 1.1 9.6 2.2 2.7 3 0 0 3 3 3 0 Molybdate transporter of MFS superfamily Rab5ip PF07019.12 EMC83196.1 - 9.6 6.9 9.8 4.3 8.0 0.2 3.5 2 1 1 3 3 3 0 Rab5-interacting protein (Rab5ip) T-box_assoc PF16176.5 EMC83197.1 - 4.9e-110 367.0 3.9 6.9e-110 366.5 3.9 1.2 1 0 0 1 1 1 1 T-box transcription factor-associated T-box PF00907.22 EMC83197.1 - 2.1e-76 256.3 0.4 3e-76 255.8 0.4 1.2 1 0 0 1 1 1 1 T-box Cmc1 PF08583.10 EMC83198.1 - 8.7e-16 57.7 5.5 1.2e-15 57.3 5.5 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.13 EMC83198.1 - 0.021 14.5 1.4 0.021 14.5 1.4 2.0 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Colipase PF01114.18 EMC83198.1 - 0.025 14.2 1.6 0.04 13.6 1.6 1.4 1 0 0 1 1 1 0 Colipase, N-terminal domain GCK PF07802.11 EMC83198.1 - 0.11 12.9 5.3 0.16 12.4 5.0 1.5 1 1 0 1 1 1 0 GCK domain ecTbetaR2 PF08917.10 EMC83199.1 - 6.6e-43 145.1 16.6 2e-42 143.6 16.6 1.8 1 0 0 1 1 1 1 Transforming growth factor beta receptor 2 ectodomain Pkinase_Tyr PF07714.17 EMC83199.1 - 7.3e-36 123.8 0.0 1.3e-35 122.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC83199.1 - 8e-34 117.2 0.0 1.3e-33 116.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 EMC83199.1 - 0.016 14.1 1.0 0.19 10.7 0.0 2.2 2 0 0 2 2 2 0 Haspin like kinase domain Pkinase_fungal PF17667.1 EMC83199.1 - 0.017 13.9 0.0 0.034 12.9 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EMC83199.1 - 0.022 14.7 0.1 0.036 14.0 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family FixQ PF05545.11 EMC83199.1 - 0.091 12.7 0.3 0.26 11.3 0.1 1.8 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ Glyco_transf_36 PF06165.11 EMC83199.1 - 0.12 11.7 0.2 0.21 11.0 0.2 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 36 C_tripleX PF02363.19 EMC83200.1 - 0.41 11.0 34.9 12 6.4 8.0 3.3 1 1 1 2 2 2 0 Cysteine rich repeat MAM PF00629.23 EMC83201.1 - 1.1e-50 171.7 0.0 2.2e-50 170.7 0.0 1.5 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu Ig_3 PF13927.6 EMC83201.1 - 1.6e-40 137.5 3.6 4.1e-13 49.7 0.1 4.2 4 0 0 4 4 4 3 Immunoglobulin domain I-set PF07679.16 EMC83201.1 - 2.1e-37 127.0 0.0 1.2e-11 44.5 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 EMC83201.1 - 4.1e-30 103.8 0.1 3.5e-09 36.7 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 EMC83201.1 - 1e-29 102.6 0.2 1.6e-09 38.0 0.0 4.4 4 0 0 4 4 4 3 Immunoglobulin domain V-set PF07686.17 EMC83201.1 - 5e-15 55.6 6.2 0.0083 16.3 0.3 6.9 4 3 1 5 5 5 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC83201.1 - 8.7e-07 28.9 0.3 0.021 14.9 0.0 3.4 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 EMC83201.1 - 0.00038 20.0 0.0 0.33 10.5 0.0 3.5 3 0 0 3 3 3 1 Immunoglobulin domain Ig_4 PF16680.5 EMC83201.1 - 0.00067 19.9 0.0 2 8.8 0.0 3.5 3 1 0 3 3 3 2 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 EMC83201.1 - 0.0015 18.6 0.0 1.2 9.3 0.0 3.0 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain BiPBP_C PF06832.12 EMC83201.1 - 0.026 14.6 0.0 0.075 13.1 0.0 1.8 1 0 0 1 1 1 0 Penicillin-Binding Protein C-terminus Family Marek_A PF02124.15 EMC83201.1 - 0.036 13.9 0.0 0.097 12.5 0.0 1.7 1 0 0 1 1 1 0 Marek's disease glycoprotein A C1-set PF07654.15 EMC83201.1 - 0.083 13.3 0.1 0.53 10.7 0.0 2.4 3 0 0 3 3 3 0 Immunoglobulin C1-set domain Helicase_C PF00271.31 EMC83202.1 - 1.3e-13 51.3 0.0 1.9e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EMC83202.1 - 0.0078 15.5 0.1 0.012 14.8 0.0 1.3 1 1 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase zf-C2H2_4 PF13894.6 EMC83203.1 - 1.2e-07 32.0 18.5 0.0082 16.9 0.5 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EMC83203.1 - 2.3e-05 24.6 7.3 0.0068 16.7 1.4 3.2 3 0 0 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EMC83203.1 - 0.00051 20.3 18.0 0.013 16.0 0.4 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 EMC83203.1 - 0.011 15.5 4.9 3 7.7 0.0 2.8 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_9 PF16293.5 EMC83203.1 - 0.019 14.8 0.6 3.3 7.6 0.0 2.5 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) DUF2256 PF10013.9 EMC83203.1 - 0.032 14.3 3.2 5.3 7.3 0.0 2.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-met PF12874.7 EMC83203.1 - 0.047 14.1 5.6 16 6.0 0.1 3.6 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMC83203.1 - 0.053 13.8 2.2 0.053 13.8 2.2 3.9 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2_12 PF18658.1 EMC83203.1 - 0.072 12.7 7.1 0.95 9.1 4.3 2.5 1 1 0 2 2 2 0 Zinc-finger C2H2-type zf-C2H2_3rep PF18868.1 EMC83203.1 - 0.1 13.2 4.9 3.6 8.3 0.2 3.2 3 0 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats Vps39_2 PF10367.9 EMC83203.1 - 0.13 12.7 8.3 0.75 10.3 8.4 2.2 1 1 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 zf-C2H2_6 PF13912.6 EMC83203.1 - 0.2 11.7 14.4 0.27 11.3 0.1 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger DUF629 PF04780.12 EMC83203.1 - 0.21 10.1 3.2 0.67 8.4 2.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF629) DUF4535 PF15054.6 EMC83203.1 - 1.3 8.8 4.5 3.2 7.6 4.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4535) zf-H2C2_2 PF13465.6 EMC83203.1 - 2.8 8.5 0.0 2.8 8.5 0.0 5.1 5 1 0 5 5 3 0 Zinc-finger double domain GAGA PF09237.11 EMC83203.1 - 6.4 6.7 10.4 0.78 9.6 0.1 3.1 3 0 0 3 3 3 0 GAGA factor ANF_receptor PF01094.28 EMC83204.1 - 7.1e-21 74.7 0.0 7.8e-21 74.6 0.0 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region Collagen PF01391.18 EMC83205.1 - 0.29 10.9 6.1 1.6 8.6 1.2 2.2 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) Meis_PKNOX_N PF16493.5 EMC83207.1 - 1.7e-39 134.0 1.4 3.1e-39 133.2 1.4 1.4 1 0 0 1 1 1 1 N-terminal of Homeobox Meis and PKNOX1 Homeobox_KN PF05920.11 EMC83207.1 - 1e-19 70.1 2.3 2.2e-19 69.1 2.3 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EMC83207.1 - 5.6e-08 32.5 0.5 1.3e-07 31.3 0.5 1.6 1 0 0 1 1 1 1 Homeodomain RNA_pol_3_Rpc31 PF11705.8 EMC83207.1 - 0.021 15.1 8.2 0.05 13.9 8.2 1.6 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Pox_Ag35 PF03286.14 EMC83207.1 - 0.063 13.1 2.6 0.43 10.3 2.8 2.1 2 0 0 2 2 2 0 Pox virus Ag35 surface protein dDENN PF03455.19 EMC83207.1 - 0.12 12.3 1.6 5.7 7.0 0.0 2.6 2 0 0 2 2 2 0 dDENN domain Med4 PF10018.9 EMC83207.1 - 0.19 11.4 9.3 0.48 10.1 0.0 2.3 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Na_trans_assoc PF06512.13 EMC83207.1 - 0.25 11.6 5.2 0.091 13.0 2.4 1.7 2 0 0 2 2 2 0 Sodium ion transport-associated NOA36 PF06524.12 EMC83207.1 - 0.35 10.2 10.5 0.03 13.6 5.9 1.5 2 0 0 2 2 2 0 NOA36 protein TFIIA PF03153.13 EMC83207.1 - 0.45 10.5 8.7 0.072 13.1 4.7 1.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Nop14 PF04147.12 EMC83207.1 - 0.86 7.7 9.4 1.5 6.9 9.4 1.3 1 0 0 1 1 1 0 Nop14-like family TRAP_alpha PF03896.16 EMC83207.1 - 0.99 8.6 9.2 1.8 7.7 9.2 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Paf1 PF03985.13 EMC83207.1 - 1.3 8.0 12.0 2 7.3 12.0 1.2 1 0 0 1 1 1 0 Paf1 DNA_pol_phi PF04931.13 EMC83207.1 - 1.5 6.8 13.7 2.8 6.0 13.7 1.3 1 0 0 1 1 1 0 DNA polymerase phi DUF4746 PF15928.5 EMC83207.1 - 6 6.2 11.5 10 5.4 11.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RPN2_C PF18004.1 EMC83207.1 - 7 6.5 8.1 15 5.5 8.1 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Radial_spoke PF04712.12 EMC83207.1 - 9.7 5.0 13.1 16 4.3 13.1 1.3 1 0 0 1 1 1 0 Radial spokehead-like protein MFS_1 PF07690.16 EMC83208.1 - 4.3e-40 137.7 31.5 4.8e-35 121.1 21.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EMC83208.1 - 0.00013 20.4 0.6 0.003 15.9 0.0 2.7 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.7 EMC83208.1 - 0.55 9.0 18.8 0.033 13.1 10.4 2.4 2 1 0 2 2 2 0 MFS_1 like family Ig_3 PF13927.6 EMC83209.1 - 3.9e-15 56.2 0.0 1.4e-10 41.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC83209.1 - 5.6e-14 52.0 0.0 6.5e-08 32.5 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 EMC83209.1 - 4.2e-10 39.8 0.1 2.1e-06 27.8 0.0 2.9 2 1 1 3 3 3 2 Immunoglobulin V-set domain Ig_2 PF13895.6 EMC83209.1 - 1.4e-08 35.0 0.0 2.1e-07 31.2 0.0 2.3 2 1 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 EMC83209.1 - 9.9e-08 32.1 0.0 0.0029 17.7 0.1 3.1 2 1 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 EMC83211.1 - 3e-14 53.4 0.0 1.6e-09 38.2 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 EMC83211.1 - 9.1e-14 51.4 0.1 9e-07 29.0 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC83211.1 - 2.1e-11 43.7 0.0 8.1e-07 29.0 0.0 2.4 2 1 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 EMC83211.1 - 1e-10 41.8 0.3 0.0015 18.7 0.0 3.1 2 1 1 3 3 3 3 Immunoglobulin V-set domain Ig_2 PF13895.6 EMC83211.1 - 1.5e-10 41.2 0.1 3.6e-07 30.4 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_6 PF18452.1 EMC83211.1 - 0.0004 19.9 0.0 0.18 11.4 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_5 PF16681.5 EMC83211.1 - 0.00093 19.6 0.0 0.03 14.7 0.0 2.3 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 EMC83211.1 - 0.0036 17.5 0.0 0.3 11.4 0.0 2.8 2 1 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain Herpes_gE PF02480.16 EMC83211.1 - 0.011 14.5 0.1 0.25 10.0 0.0 2.0 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein E C2-set_2 PF08205.12 EMC83211.1 - 0.02 14.9 0.3 0.063 13.4 0.2 1.8 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain RIIa PF02197.17 EMC83212.1 - 1.9e-13 49.8 0.2 2.2e-13 49.6 0.2 1.1 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit PseudoU_synth_1 PF01416.20 EMC83213.1 - 1.1e-35 122.3 0.0 6.4e-33 113.5 0.0 2.4 2 0 0 2 2 2 2 tRNA pseudouridine synthase Shugoshin_N PF07558.11 EMC83213.1 - 0.036 13.9 0.1 0.062 13.2 0.1 1.4 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region DUF1192 PF06698.11 EMC83213.1 - 0.064 13.3 0.2 0.13 12.4 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) DUF2076 PF09849.9 EMC83213.1 - 0.15 12.0 0.2 0.22 11.5 0.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Lzipper-MIP1 PF14389.6 EMC83213.1 - 0.23 11.8 2.5 0.58 10.5 2.5 1.7 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 bZIP_2 PF07716.15 EMC83213.1 - 0.32 11.1 2.6 0.65 10.1 2.6 1.4 1 0 0 1 1 1 0 Basic region leucine zipper BST2 PF16716.5 EMC83213.1 - 0.56 10.8 3.0 0.32 11.6 0.5 1.8 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 HYLS1_C PF15311.6 EMC83214.1 - 6.2e-31 107.0 1.8 8.5e-31 106.6 1.8 1.2 1 0 0 1 1 1 1 Hydrolethalus syndrome protein 1 C-terminus DEAD PF00270.29 EMC83215.1 - 1.4e-28 99.9 0.2 9.3e-28 97.2 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC83215.1 - 1.1e-27 96.5 0.1 2.4e-27 95.4 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC83215.1 - 0.0038 17.3 0.0 0.007 16.4 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EMC83215.1 - 0.0098 15.6 0.0 0.022 14.5 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EMC83215.1 - 0.033 14.5 0.2 0.69 10.2 0.1 2.3 2 1 0 2 2 2 0 AAA domain Baculo_VP1054 PF05789.11 EMC83217.1 - 0.036 13.3 0.0 0.042 13.1 0.0 1.1 1 0 0 1 1 1 0 Baculovirus VP1054 protein EI24 PF07264.11 EMC83219.1 - 1e-19 71.4 19.4 1.3e-19 71.1 18.7 1.5 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Keratin_assoc PF09775.9 EMC83219.1 - 6.4 6.4 9.4 0.32 10.6 0.3 2.6 3 0 0 3 3 3 0 Keratinocyte-associated protein 2 TRAM_LAG1_CLN8 PF03798.16 EMC83220.1 - 2.8e-15 56.6 7.4 9.6e-15 54.8 7.2 1.8 1 1 1 2 2 2 1 TLC domain ANF_receptor PF01094.28 EMC83221.1 - 0.00077 18.7 0.0 0.00096 18.4 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region TM1506 PF08973.10 EMC83221.1 - 0.16 11.6 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1893) ANF_receptor PF01094.28 EMC83222.1 - 4.6e-61 206.9 0.0 7.7e-61 206.2 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.26 EMC83222.1 - 3.6e-48 163.2 0.1 5.7e-48 162.5 0.1 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 EMC83222.1 - 1.8e-44 150.6 0.0 5.4e-44 149.1 0.0 1.8 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 EMC83222.1 - 8e-20 71.2 0.0 1.5e-19 70.3 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.6 EMC83222.1 - 0.2 11.3 0.0 0.4 10.3 0.0 1.5 1 1 0 1 1 1 0 Periplasmic binding protein LRR_9 PF14580.6 EMC83223.1 - 4e-10 39.5 4.1 1.9e-07 30.7 0.3 3.2 2 1 1 3 3 3 2 Leucine-rich repeat LRR_8 PF13855.6 EMC83223.1 - 1.2e-07 31.4 16.6 0.0026 17.5 2.0 4.3 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EMC83223.1 - 1.4e-07 31.7 28.9 0.0029 18.0 4.8 5.8 2 2 5 7 7 7 5 Leucine Rich repeats (2 copies) Ubiquitin_2 PF14560.6 EMC83223.1 - 1.6e-07 31.7 0.1 6e-07 29.8 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin-like domain ubiquitin PF00240.23 EMC83223.1 - 0.0017 18.1 0.2 0.0092 15.7 0.2 2.1 1 1 0 1 1 1 1 Ubiquitin family UN_NPL4 PF11543.8 EMC83223.1 - 0.011 16.2 0.0 0.021 15.3 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 ALS2CR8 PF15299.6 EMC83223.1 - 0.038 13.9 0.0 0.066 13.1 0.0 1.3 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 LRR_6 PF13516.6 EMC83223.1 - 0.064 13.3 17.1 1.5 9.1 0.0 4.8 5 0 0 5 5 5 0 Leucine Rich repeat APG12 PF04110.13 EMC83223.1 - 0.086 13.3 0.0 0.2 12.1 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-like autophagy protein Apg12 PB1 PF00564.24 EMC83223.1 - 0.13 12.2 0.1 0.38 10.7 0.1 1.8 1 0 0 1 1 1 0 PB1 domain LRR_1 PF00560.33 EMC83223.1 - 6.3 7.8 15.0 4.7 8.2 0.1 5.5 5 1 0 5 5 4 0 Leucine Rich Repeat FA_hydroxylase PF04116.13 EMC83224.1 - 3.5e-24 85.6 24.4 5.9e-24 84.9 21.1 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Sortilin-Vps10 PF15902.5 EMC83225.1 - 1.7e-111 373.2 0.0 2.2e-111 372.8 0.0 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.18 EMC83225.1 - 3.2e-85 280.0 160.4 1.5e-13 50.7 14.7 9.4 8 1 1 9 9 9 8 Low-density lipoprotein receptor domain class A Sortilin_C PF15901.5 EMC83225.1 - 1.3e-40 139.6 0.1 1.3e-40 139.6 0.1 4.8 2 1 4 6 6 6 1 Sortilin, neurotensin receptor 3, C-terminal Ldl_recept_b PF00058.17 EMC83225.1 - 1.5e-25 89.3 5.9 1.8e-08 34.7 0.1 5.6 5 0 0 5 5 5 5 Low-density lipoprotein receptor repeat class B BNR PF02012.20 EMC83225.1 - 6.1e-05 22.4 15.1 1.2 9.4 0.2 5.8 5 0 0 5 5 5 4 BNR/Asp-box repeat BNR_6 PF15899.5 EMC83225.1 - 0.00043 20.1 7.0 0.3 11.2 0.8 3.6 3 0 0 3 3 3 2 BNR-Asp box repeat fn3 PF00041.21 EMC83226.1 - 9e-07 29.2 0.8 0.00033 21.0 0.3 2.3 2 0 0 2 2 2 2 Fibronectin type III domain fn3_2 PF16893.5 EMC83226.1 - 0.0059 16.7 0.7 1.3 9.3 0.1 3.2 2 2 1 3 3 3 1 Fibronectin type III domain fn3 PF00041.21 EMC83227.1 - 7.6e-12 45.4 0.0 1.9e-06 28.1 0.1 2.3 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 EMC83227.1 - 0.0019 18.7 0.2 0.039 14.5 0.1 2.2 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 EMC83227.1 - 0.0044 17.3 0.1 2.7 8.4 0.1 2.3 2 0 0 2 2 2 2 Interferon-alpha/beta receptor, fibronectin type III DUF3377 PF11857.8 EMC83227.1 - 0.0051 16.7 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) DUF4448 PF14610.6 EMC83227.1 - 0.012 15.4 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) fn3_2 PF16893.5 EMC83227.1 - 0.053 13.7 0.3 0.19 11.9 0.0 2.0 2 1 0 2 2 2 0 Fibronectin type III domain PagP PF07017.11 EMC83227.1 - 0.075 12.4 0.4 4.7 6.6 0.1 2.4 1 1 1 2 2 2 0 Antimicrobial peptide resistance and lipid A acylation protein PagP DUF3290 PF11694.8 EMC83227.1 - 0.11 12.5 0.9 5.8 6.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) TadE PF07811.12 EMC83227.1 - 0.2 11.9 1.3 0.43 10.9 1.3 1.5 1 0 0 1 1 1 0 TadE-like protein DUF1410 PF07198.11 EMC83227.1 - 0.26 11.8 2.6 9.5 6.8 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1410) RVT_1 PF00078.27 EMC83228.1 - 0.042 13.3 0.0 0.057 12.9 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) SH3_9 PF14604.6 EMC83229.1 - 9.9e-18 63.7 0.0 2.1e-17 62.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain His_Phos_1 PF00300.22 EMC83229.1 - 3.5e-17 62.7 0.0 9.7e-17 61.3 0.0 1.7 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) 2_5_RNA_ligase2 PF13563.6 EMC83229.1 - 1.4e-05 25.0 0.6 3.7e-05 23.7 0.3 1.8 2 0 0 2 2 2 1 2'-5' RNA ligase superfamily SH3_1 PF00018.28 EMC83229.1 - 4.5e-05 23.0 0.0 9.4e-05 21.9 0.0 1.6 1 0 0 1 1 1 1 SH3 domain LigT_PEase PF02834.16 EMC83229.1 - 5.8e-05 23.2 0.1 0.32 11.2 0.1 2.7 3 0 0 3 3 3 2 LigT like Phosphoesterase His_Phos_2 PF00328.22 EMC83229.1 - 0.12 11.7 0.0 0.24 10.7 0.0 1.5 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) Ig_3 PF13927.6 EMC83230.1 - 3.3e-11 43.6 0.1 3.9e-05 24.2 0.0 3.1 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC83230.1 - 6.9e-11 42.1 0.0 0.00022 21.3 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 EMC83230.1 - 3.5e-09 36.7 3.7 8e-06 25.9 0.0 3.0 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 EMC83230.1 - 1.6e-08 34.6 0.7 8.8e-07 29.1 0.1 2.8 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.6 EMC83230.1 - 1.5e-07 31.7 0.2 0.0015 18.8 0.0 2.9 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 EMC83230.1 - 2.7e-07 30.6 3.1 3.7e-07 30.1 0.2 2.6 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 EMC83230.1 - 3.7e-05 24.0 0.2 0.00021 21.6 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin C1-set domain DUF1180 PF06679.12 EMC83230.1 - 0.0074 16.7 0.5 0.015 15.7 0.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) Izumo-Ig PF16706.5 EMC83230.1 - 0.034 14.2 0.0 0.072 13.2 0.0 1.5 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain DUF4630 PF15443.6 EMC83230.1 - 0.13 12.5 0.0 1.1 9.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4630) DUF3169 PF11368.8 EMC83230.1 - 0.14 11.7 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) TMEM51 PF15345.6 EMC83230.1 - 0.21 11.4 7.7 0.51 10.1 0.1 2.2 1 1 1 2 2 2 0 Transmembrane protein 51 DUF5527 PF17665.1 EMC83230.1 - 0.6 9.7 2.3 0.47 10.0 0.1 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5527) TMEM154 PF15102.6 EMC83230.1 - 5.6 6.9 11.2 35 4.3 11.2 2.3 1 1 0 1 1 1 0 TMEM154 protein family UL73_N PF12522.8 EMC83230.1 - 9.6 6.1 8.9 8.8 6.2 1.1 2.7 2 0 0 2 2 2 0 Cytomegalovirus glycoprotein N terminal Homeodomain PF00046.29 EMC83231.1 - 1.6e-10 40.7 7.2 4.2e-05 23.3 0.1 2.3 1 1 1 2 2 2 2 Homeodomain HSP70 PF00012.20 EMC83232.1 - 2.5e-229 762.5 10.8 2.8e-229 762.3 10.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EMC83232.1 - 2e-17 63.0 0.1 3.3e-17 62.3 0.1 1.2 1 0 0 1 1 1 1 MreB/Mbl protein FGGY_C PF02782.16 EMC83232.1 - 0.0015 18.3 0.0 0.0042 16.8 0.0 1.7 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.10 EMC83232.1 - 0.026 13.5 0.3 0.15 11.0 0.3 2.0 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain HORMA PF02301.18 EMC83232.1 - 0.072 12.7 1.3 0.19 11.3 1.3 1.7 1 0 0 1 1 1 0 HORMA domain MetOD2 PF18548.1 EMC83232.1 - 0.27 11.4 0.1 0.27 11.4 0.1 3.1 2 1 1 3 3 3 0 Metanogen output domain 2 Membralin PF09746.9 EMC83232.1 - 5.2 6.0 4.8 9 5.2 4.8 1.3 1 0 0 1 1 1 0 Tumour-associated protein SMN PF06003.12 EMC83234.1 - 0.00069 19.0 0.7 0.0008 18.8 0.7 1.0 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) FAM176 PF14851.6 EMC83234.1 - 0.0027 17.4 0.1 0.0037 16.9 0.1 1.3 1 0 0 1 1 1 1 FAM176 family Miga PF10265.9 EMC83234.1 - 0.005 15.9 0.5 0.0053 15.8 0.5 1.0 1 0 0 1 1 1 1 Mitoguardin TMEM51 PF15345.6 EMC83234.1 - 0.011 15.6 3.6 0.037 13.9 3.5 1.8 1 1 0 1 1 1 0 Transmembrane protein 51 EphA2_TM PF14575.6 EMC83234.1 - 0.02 15.8 0.3 0.043 14.7 0.3 1.7 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain OSTbeta PF15048.6 EMC83234.1 - 0.02 15.0 0.3 0.057 13.6 0.3 1.7 1 1 0 1 1 1 0 Organic solute transporter subunit beta protein Med13_C PF06333.12 EMC83234.1 - 0.052 12.8 3.0 0.067 12.5 3.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain Zip PF02535.22 EMC83234.1 - 0.053 12.7 0.0 0.064 12.5 0.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Syndecan PF01034.20 EMC83234.1 - 0.092 12.7 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Syndecan domain Trp_oprn_chp PF09534.10 EMC83234.1 - 0.11 12.3 0.2 0.25 11.1 0.1 1.7 1 1 1 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) RCR PF12273.8 EMC83234.1 - 0.13 13.0 3.2 0.34 11.6 3.2 1.6 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red PDE6_gamma PF04868.12 EMC83234.1 - 0.13 12.5 0.3 0.24 11.7 0.3 1.4 1 0 0 1 1 1 0 Retinal cGMP phosphodiesterase, gamma subunit THEG4 PF15834.5 EMC83234.1 - 0.57 10.2 2.6 0.39 10.7 0.3 1.7 1 1 1 2 2 2 0 Testis highly expressed protein 4 ANAPC1 PF12859.7 EMC83234.1 - 0.89 10.1 5.9 1.2 9.7 5.9 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 1 DUF3446 PF11928.8 EMC83234.1 - 2.7 8.4 11.4 4.1 7.8 11.4 1.2 1 0 0 1 1 1 0 Early growth response N-terminal domain V-set PF07686.17 EMC83235.1 - 3.1e-08 33.8 0.0 3.4e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.16 EMC83235.1 - 2.1e-07 30.9 0.0 2.6e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC83235.1 - 7.8e-05 22.8 0.0 8.3e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC83235.1 - 0.00044 20.8 0.0 0.00065 20.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_6 PF18452.1 EMC83235.1 - 0.0013 18.3 0.0 0.0015 18.0 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain Izumo-Ig PF16706.5 EMC83235.1 - 0.16 12.1 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain VASt PF16016.5 EMC83236.1 - 2.1e-37 128.9 2.0 3.3e-37 128.3 2.0 1.3 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EMC83236.1 - 2.2e-28 98.4 0.1 4e-28 97.6 0.1 1.5 1 0 0 1 1 1 1 GRAM domain V-set PF07686.17 EMC83237.1 - 2.6e-20 72.6 0.2 3.7e-20 72.1 0.2 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 EMC83237.1 - 6.4e-05 23.0 0.7 0.00013 22.0 0.7 1.5 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC83237.1 - 9.3e-05 23.0 0.6 0.0003 21.3 0.6 1.8 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC83237.1 - 0.00013 21.9 0.3 0.00038 20.5 0.3 1.8 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC83237.1 - 0.00042 20.6 0.3 0.0012 19.2 0.3 1.8 1 1 0 1 1 1 1 Immunoglobulin domain Ig_6 PF18452.1 EMC83237.1 - 0.02 14.5 0.0 0.068 12.7 0.0 1.9 1 0 0 1 1 1 0 Immunoglobulin domain EII-GUT PF03608.13 EMC83237.1 - 0.03 14.3 0.1 0.05 13.5 0.1 1.2 1 0 0 1 1 1 0 PTS system enzyme II sorbitol-specific factor Ac76 PF05814.11 EMC83237.1 - 0.061 13.3 1.3 0.11 12.6 0.9 1.6 2 0 0 2 2 2 0 Orf76 (Ac76) E1-E2_ATPase PF00122.20 EMC83238.1 - 2.1e-45 154.5 1.4 2.1e-45 154.5 1.4 2.9 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EMC83238.1 - 2.5e-42 144.7 1.4 2.5e-42 144.7 1.4 2.8 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 EMC83238.1 - 1.2e-26 92.6 0.0 2.6e-26 91.5 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EMC83238.1 - 9.7e-22 78.3 0.0 1.9e-12 47.9 0.0 2.6 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EMC83238.1 - 6.9e-16 57.7 0.0 1.4e-15 56.7 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EMC83238.1 - 8.3e-05 22.4 9.1 0.00042 20.1 1.2 2.9 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Sigma70_r4 PF04545.16 EMC83238.1 - 0.02 14.4 0.1 0.053 13.0 0.1 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 HAD PF12710.7 EMC83238.1 - 0.03 14.7 0.1 0.2 12.0 0.1 2.2 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Glyco_transf_43 PF03360.16 EMC83240.1 - 1.2e-34 119.9 0.0 1.4e-34 119.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 43 Acyl-CoA_dh_1 PF00441.24 EMC83241.1 - 9.2e-46 155.8 4.7 1.3e-45 155.2 4.7 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EMC83241.1 - 1.4e-30 106.2 0.0 3.2e-30 105.1 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EMC83241.1 - 6.5e-25 87.2 0.0 1.4e-24 86.1 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EMC83241.1 - 8.9e-22 77.8 2.2 1.4e-21 77.2 2.2 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain EVE PF01878.18 EMC83242.1 - 1.1e-49 168.2 0.0 1.1e-49 168.2 0.0 1.5 2 0 0 2 2 2 1 EVE domain Vps26 PF03643.15 EMC83243.1 - 3.9e-131 436.1 6.2 4.7e-131 435.8 6.2 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 EMC83243.1 - 0.00011 22.3 0.7 0.084 12.9 0.0 3.1 2 1 1 3 3 3 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EMC83243.1 - 0.0011 19.4 0.3 0.041 14.3 0.0 2.5 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Cnd1 PF12717.7 EMC83244.1 - 6.1e-38 130.4 26.3 5.9e-28 97.9 0.3 8.3 7 1 2 9 9 9 4 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EMC83244.1 - 6.3e-13 47.8 12.4 0.17 12.2 0.1 8.5 8 0 0 8 8 8 4 HEAT repeat Adaptin_N PF01602.20 EMC83244.1 - 4.2e-10 38.8 15.4 8e-05 21.4 6.2 4.4 4 2 0 4 4 4 3 Adaptin N terminal region HEAT_2 PF13646.6 EMC83244.1 - 4.7e-08 33.3 5.2 0.00092 19.6 0.2 5.8 6 1 0 7 7 7 2 HEAT repeats RTP1_C1 PF10363.9 EMC83244.1 - 6.2e-06 26.4 3.0 1.1 9.5 0.1 6.2 6 0 0 6 6 6 1 Required for nuclear transport of RNA pol II C-terminus 1 Cohesin_HEAT PF12765.7 EMC83244.1 - 4e-05 23.8 0.3 3.3 8.1 0.0 4.7 4 0 0 4 4 4 1 HEAT repeat associated with sister chromatid cohesion OSCP PF00213.18 EMC83244.1 - 0.066 13.3 0.4 0.38 10.9 0.4 2.3 1 0 0 1 1 1 0 ATP synthase delta (OSCP) subunit SKA2 PF16740.5 EMC83244.1 - 0.071 12.9 8.3 0.53 10.1 0.0 3.4 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 2 HEAT_EZ PF13513.6 EMC83244.1 - 0.2 12.2 6.8 28 5.3 0.0 6.2 6 1 1 7 7 7 0 HEAT-like repeat CPG4 PF15481.6 EMC83244.1 - 1.9 9.2 12.9 0.081 13.6 4.1 3.4 4 0 0 4 4 2 0 Chondroitin proteoglycan 4 UNC45-central PF11701.8 EMC83244.1 - 2.1 8.3 8.2 7.1 6.6 0.1 4.8 4 1 0 4 4 4 0 Myosin-binding striated muscle assembly central Ig_3 PF13927.6 EMC83245.1 - 9.1e-23 80.7 3.8 3.9e-13 49.8 0.8 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC83245.1 - 1.8e-20 72.8 0.5 9.6e-11 41.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 EMC83245.1 - 4e-14 52.7 1.9 2.3e-08 34.2 0.1 2.8 2 1 0 2 2 2 2 Immunoglobulin V-set domain Ig_2 PF13895.6 EMC83245.1 - 8.8e-14 51.6 4.2 1.6e-09 38.0 1.0 2.7 1 1 1 2 2 2 2 Immunoglobulin domain ig PF00047.25 EMC83245.1 - 4.8e-13 49.1 1.7 3.3e-06 27.2 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Izumo-Ig PF16706.5 EMC83245.1 - 9.5e-06 25.6 0.1 0.0013 18.8 0.0 2.7 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain C1-set PF07654.15 EMC83245.1 - 7.3e-05 23.1 1.0 0.089 13.2 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin C1-set domain C2-set_2 PF08205.12 EMC83245.1 - 0.00021 21.3 0.5 0.026 14.6 0.1 2.4 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Adeno_E3_CR2 PF02439.15 EMC83245.1 - 0.17 11.6 4.6 0.32 10.8 4.6 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Ig_3 PF13927.6 EMC83246.1 - 3e-61 204.0 0.0 1.5e-15 57.5 0.0 5.4 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 EMC83246.1 - 1.1e-53 179.3 0.0 7.9e-15 54.7 0.0 5.7 6 0 0 6 6 6 5 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC83246.1 - 1.7e-38 130.8 0.0 3.6e-09 36.8 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 EMC83246.1 - 1.4e-34 118.1 0.0 3.9e-11 43.0 0.0 6.1 5 1 0 5 5 5 5 Immunoglobulin domain V-set PF07686.17 EMC83246.1 - 6.1e-26 90.7 0.1 8.2e-08 32.4 0.0 7.0 4 2 1 6 6 6 5 Immunoglobulin V-set domain fn3 PF00041.21 EMC83246.1 - 5e-14 52.4 0.1 1.6e-05 25.1 0.0 3.0 3 0 0 3 3 2 2 Fibronectin type III domain Ig_6 PF18452.1 EMC83246.1 - 1.1e-09 37.7 0.0 0.33 10.6 0.0 5.3 5 0 0 5 5 5 2 Immunoglobulin domain Ig_4 PF16680.5 EMC83246.1 - 2.2e-08 34.2 0.0 0.011 16.0 0.0 5.1 5 0 0 5 5 5 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 EMC83246.1 - 8.8e-06 25.7 0.0 5.6 7.1 0.0 4.4 4 0 0 4 4 4 2 Izumo-like Immunoglobulin domain C2-set_2 PF08205.12 EMC83246.1 - 9.1e-06 25.7 0.6 0.017 15.1 0.0 4.5 5 0 0 5 5 5 1 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 EMC83246.1 - 2.4e-05 24.6 0.0 0.24 11.8 0.0 5.0 5 0 0 5 5 5 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_C17orf99 PF17736.1 EMC83246.1 - 0.00053 20.0 0.0 0.32 11.1 0.0 4.5 4 2 0 4 4 4 1 C17orf99 Ig domain Pur_ac_phosph_N PF16656.5 EMC83246.1 - 0.0081 16.7 0.3 0.71 10.5 0.5 3.2 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Tissue_fac PF01108.17 EMC83246.1 - 0.018 14.9 0.2 0.18 11.7 0.1 2.5 3 0 0 3 3 3 0 Tissue factor Ldr_toxin PF13940.6 EMC83246.1 - 0.02 14.9 1.9 4.7 7.4 0.3 3.3 2 1 1 3 3 3 0 Toxin Ldr, type I toxin-antitoxin system V-set_CD47 PF08204.11 EMC83246.1 - 0.088 12.8 0.0 21 5.1 0.0 3.7 4 0 0 4 4 4 0 CD47 immunoglobulin-like domain DUF2369 PF10179.9 EMC83246.1 - 0.2 12.1 0.0 5.5 7.4 0.0 3.1 4 0 0 4 4 4 0 Uncharacterised conserved protein (DUF2369) Ig_3 PF13927.6 EMC83247.1 - 5.8e-37 126.2 1.9 4.9e-15 55.9 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 EMC83247.1 - 1.3e-36 124.6 2.8 5.8e-15 55.1 0.0 3.7 3 1 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 EMC83247.1 - 1.5e-27 95.6 4.1 6.9e-14 51.8 0.0 3.9 3 1 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 EMC83247.1 - 4.2e-27 94.3 1.8 7.6e-11 42.2 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 EMC83247.1 - 2.4e-14 53.4 6.7 0.00014 22.0 0.1 5.1 3 2 1 4 4 4 4 Immunoglobulin V-set domain Izumo-Ig PF16706.5 EMC83247.1 - 3e-08 33.6 0.1 0.0068 16.4 0.0 3.5 3 0 0 3 3 3 2 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 EMC83247.1 - 4.8e-08 33.3 0.0 0.15 12.5 0.0 3.4 3 1 0 3 3 3 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 EMC83247.1 - 3.5e-05 23.3 0.0 0.99 9.0 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin domain Ig_4 PF16680.5 EMC83247.1 - 5e-05 23.5 0.1 0.29 11.4 0.0 3.7 3 1 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain V-set_CD47 PF08204.11 EMC83247.1 - 0.00014 21.8 1.0 0.35 10.9 0.1 3.1 3 0 0 3 3 3 2 CD47 immunoglobulin-like domain C2-set_2 PF08205.12 EMC83247.1 - 0.012 15.7 0.3 0.79 9.8 0.0 2.6 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 EMC83248.1 - 1.9e-35 121.3 0.8 2.2e-14 53.8 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 EMC83248.1 - 6.8e-35 119.0 0.2 2.5e-13 49.9 0.0 3.6 3 1 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 EMC83248.1 - 1.8e-29 101.7 0.2 2.2e-14 53.4 0.0 4.1 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 EMC83248.1 - 6.3e-28 96.9 0.6 1.4e-12 47.8 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 EMC83248.1 - 5.1e-15 55.6 3.6 0.00016 21.8 0.1 5.1 3 2 2 5 5 5 5 Immunoglobulin V-set domain Ig_5 PF16681.5 EMC83248.1 - 1.7e-09 38.0 0.1 0.0076 16.6 0.0 3.6 3 1 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 EMC83248.1 - 4.6e-07 29.8 0.1 0.012 15.6 0.0 3.3 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 EMC83248.1 - 5.4e-06 25.9 0.0 0.58 9.8 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin domain Ig_4 PF16680.5 EMC83248.1 - 4.1e-05 23.8 0.1 0.26 11.6 0.0 3.6 3 1 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 EMC83248.1 - 4.1e-05 23.6 0.1 0.025 14.6 0.1 2.6 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain V-set_CD47 PF08204.11 EMC83248.1 - 0.0014 18.7 0.1 0.67 9.9 0.0 3.0 3 0 0 3 3 3 1 CD47 immunoglobulin-like domain Ig_C17orf99 PF17736.1 EMC83248.1 - 0.045 13.8 0.2 1.1 9.4 0.0 2.9 2 1 0 2 2 2 0 C17orf99 Ig domain DUF1151 PF06625.11 EMC83249.1 - 2.6e-43 146.6 23.6 3.1e-43 146.3 23.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1151) HTH_43 PF09904.9 EMC83249.1 - 0.054 13.4 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix HSP70 PF00012.20 EMC83250.1 - 9.2e-106 354.4 0.1 1e-105 354.2 0.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EMC83250.1 - 3.8e-11 42.4 0.0 6.5e-11 41.6 0.0 1.3 1 0 0 1 1 1 1 MreB/Mbl protein SET PF00856.28 EMC83251.1 - 3.9e-22 79.4 0.3 1.4e-21 77.6 0.1 2.0 2 1 0 2 2 2 1 SET domain Pre-SET PF05033.16 EMC83251.1 - 8.5e-17 61.8 4.7 8.5e-17 61.8 4.7 2.7 3 0 0 3 3 3 1 Pre-SET motif Chromo PF00385.24 EMC83251.1 - 1.4e-14 53.7 1.5 2.9e-14 52.7 1.5 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AWS PF17907.1 EMC83251.1 - 0.023 14.7 2.4 0.023 14.7 2.4 3.5 3 0 0 3 3 3 0 AWS domain DRMBL PF07522.14 EMC83252.1 - 3.1e-19 69.2 0.0 5.9e-19 68.3 0.0 1.5 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 EMC83252.1 - 0.01 15.4 0.0 0.025 14.1 0.0 1.7 2 0 0 2 2 2 0 Beta-lactamase superfamily domain RMMBL PF07521.12 EMC83252.1 - 0.048 13.6 0.0 0.19 11.7 0.0 2.0 1 1 1 2 2 2 0 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 EMC83252.1 - 0.12 12.4 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Meiosis_expr PF15163.6 EMC83253.1 - 2.1e-38 130.8 9.8 2.5e-38 130.6 9.8 1.0 1 0 0 1 1 1 1 Meiosis-expressed DUF2678 PF10856.8 EMC83254.1 - 6.2e-51 171.3 5.8 6.8e-51 171.2 5.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2678) Polysacc_synt_C PF14667.6 EMC83254.1 - 2.6e-06 27.5 2.2 3.1e-06 27.3 2.2 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis C-terminal domain DUF2417 PF10329.9 EMC83254.1 - 0.038 13.4 8.0 0.082 12.3 8.0 1.5 1 1 0 1 1 1 0 Region of unknown function (DUF2417) Intg_mem_TP0381 PF09529.10 EMC83254.1 - 0.06 12.9 6.7 0.073 12.6 6.7 1.1 1 0 0 1 1 1 0 Integral membrane protein (intg_mem_TP0381) 7TMR-DISM_7TM PF07695.11 EMC83254.1 - 1.1 9.1 12.0 5.4 6.9 12.1 1.7 1 1 0 1 1 1 0 7TM diverse intracellular signalling COPI_assoc PF08507.10 EMC83254.1 - 1.1 9.3 12.3 0.22 11.6 6.0 2.0 1 1 1 2 2 2 0 COPI associated protein DUF4131 PF13567.6 EMC83254.1 - 7 6.3 6.2 2.5 7.7 2.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Myb_DNA-binding PF00249.31 EMC83255.1 - 5.4e-31 106.5 13.5 8.2e-20 70.7 0.7 4.4 4 0 0 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EMC83255.1 - 3.5e-15 56.0 5.3 1.4e-08 34.9 0.1 4.1 3 1 1 4 4 4 2 Myb-like DNA-binding domain DUF5591 PF17884.1 EMC83255.1 - 0.0075 16.1 0.4 4 7.3 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF5591) DUF3818 PF12825.7 EMC83255.1 - 0.017 14.2 1.5 0.036 13.1 1.6 1.4 1 1 0 1 1 1 0 Domain of unknown function in PX-proteins (DUF3818) Ntox15 PF15604.6 EMC83255.1 - 0.55 10.3 2.9 8.9 6.4 0.2 3.1 3 0 0 3 3 3 0 Novel toxin 15 Myb_DNA-bind_4 PF13837.6 EMC83255.1 - 1.5 9.2 8.9 0.13 12.6 0.4 3.3 4 1 0 4 4 4 0 Myb/SANT-like DNA-binding domain TLV_coat PF00429.19 EMC83256.1 - 2e-08 33.4 0.8 2.3e-08 33.2 0.8 1.0 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) Ephrin_rec_like PF07699.13 EMC83257.1 - 7.4e-09 35.2 86.6 0.00054 19.7 7.2 8.9 6 3 3 9 9 9 7 Putative ephrin-receptor like NCD3G PF07562.14 EMC83257.1 - 0.1 12.6 70.0 0.1 12.6 8.5 8.0 7 1 0 7 7 7 0 Nine Cysteines Domain of family 3 GPCR ANF_receptor PF01094.28 EMC83258.1 - 3.8e-104 348.6 0.1 4.8e-104 348.2 0.1 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.22 EMC83258.1 - 2.1e-66 224.1 23.6 3.8e-66 223.2 23.6 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.14 EMC83258.1 - 2.2e-13 50.0 12.4 5.7e-13 48.6 12.4 1.8 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.6 EMC83258.1 - 6.2e-09 36.0 0.0 1.1e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein DDE_Tnp_IS1 PF03400.13 EMC83258.1 - 0.13 12.6 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 IS1 transposase Sema PF01403.19 EMC83259.1 - 4.6e-165 549.5 0.0 1.7e-163 544.4 0.0 2.1 1 1 1 2 2 2 2 Sema domain V-set PF07686.17 EMC83259.1 - 0.0008 19.5 0.1 0.053 13.7 0.1 2.5 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC83259.1 - 0.00083 19.9 0.0 0.0021 18.6 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC83259.1 - 0.00085 19.5 0.0 0.0022 18.2 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC83259.1 - 0.00098 19.1 0.0 0.0022 18.0 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain PSI PF01437.25 EMC83259.1 - 0.0012 19.3 8.8 0.0028 18.1 8.8 1.6 1 0 0 1 1 1 1 Plexin repeat Ig_6 PF18452.1 EMC83259.1 - 0.0043 16.6 0.0 0.0087 15.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC83259.1 - 0.0066 16.8 0.1 0.049 14.0 0.0 2.5 3 0 0 3 3 3 1 Immunoglobulin domain Sema PF01403.19 EMC83260.1 - 2.8e-160 533.8 0.0 3.8e-160 533.3 0.0 1.2 1 0 0 1 1 1 1 Sema domain ig PF00047.25 EMC83260.1 - 1.1e-07 32.0 0.0 2.8e-07 30.6 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC83260.1 - 2.3e-05 24.5 0.1 0.0001 22.4 0.1 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC83260.1 - 0.0011 19.5 0.0 0.004 17.7 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC83260.1 - 0.0028 18.0 0.0 0.012 16.0 0.0 2.1 1 0 0 1 1 1 1 Immunoglobulin domain PSI PF01437.25 EMC83260.1 - 0.0029 18.1 7.0 0.0029 18.1 7.0 2.0 2 0 0 2 2 2 1 Plexin repeat I-set PF07679.16 EMC83260.1 - 0.02 14.9 0.0 0.044 13.9 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin I-set domain Ig_6 PF18452.1 EMC83260.1 - 0.044 13.3 0.0 0.096 12.3 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain Sema PF01403.19 EMC83261.1 - 6e-147 489.9 0.0 8.5e-147 489.4 0.0 1.2 1 0 0 1 1 1 1 Sema domain ig PF00047.25 EMC83261.1 - 3.3e-05 24.0 0.0 6.1e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC83261.1 - 0.00034 20.7 0.4 0.0013 18.9 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin V-set domain PSI PF01437.25 EMC83261.1 - 0.007 16.9 6.3 0.007 16.9 6.3 2.0 2 0 0 2 2 2 1 Plexin repeat VGCC_alpha2 PF08473.11 EMC83264.1 - 8.7e-208 690.4 1.1 1.4e-207 689.7 1.1 1.3 1 0 0 1 1 1 1 Neuronal voltage-dependent calcium channel alpha 2acd VWA_N PF08399.11 EMC83264.1 - 3.1e-40 137.5 0.2 3.1e-40 137.5 0.2 1.9 2 0 0 2 2 2 1 VWA N-terminal VWA PF00092.28 EMC83264.1 - 4e-22 79.3 0.4 7.1e-22 78.5 0.4 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EMC83264.1 - 5.6e-14 52.4 0.0 9.4e-14 51.6 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain dCache_1 PF02743.18 EMC83264.1 - 2.9e-11 43.6 5.7 8.3e-11 42.1 0.1 3.4 3 1 0 3 3 3 1 Cache domain VWA_2 PF13519.6 EMC83264.1 - 7.4e-11 42.7 0.2 1.9e-10 41.3 0.2 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 EMC83264.1 - 0.0033 17.5 0.4 0.0065 16.6 0.4 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus Kringle PF00051.18 EMC83265.1 - 8.5e-111 362.5 41.4 1.7e-29 101.9 6.9 4.5 4 0 0 4 4 4 4 Kringle domain Trypsin PF00089.26 EMC83265.1 - 7.1e-48 163.3 0.4 1.3e-47 162.5 0.0 1.7 2 0 0 2 2 2 1 Trypsin PAN_1 PF00024.26 EMC83265.1 - 4.3e-10 39.4 1.2 1.3e-09 37.9 1.2 1.9 1 0 0 1 1 1 1 PAN domain DUF1986 PF09342.11 EMC83265.1 - 0.0014 19.0 0.0 0.0029 18.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Sema PF01403.19 EMC83266.1 - 5.1e-148 493.4 0.0 7.4e-148 492.9 0.0 1.2 1 0 0 1 1 1 1 Sema domain I-set PF07679.16 EMC83266.1 - 6.6e-06 26.1 0.2 1.9e-05 24.6 0.1 1.9 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC83266.1 - 1.4e-05 25.6 0.1 8.1e-05 23.1 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain PSI PF01437.25 EMC83266.1 - 0.0024 18.4 7.7 0.0071 16.9 7.7 1.9 1 0 0 1 1 1 1 Plexin repeat ig PF00047.25 EMC83266.1 - 0.0053 16.9 0.0 0.019 15.1 0.0 2.0 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC83266.1 - 0.0074 16.6 0.0 0.022 15.1 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC83266.1 - 0.0081 16.3 0.1 0.2 11.8 0.1 2.9 1 1 0 1 1 1 1 Immunoglobulin V-set domain CD36 PF01130.21 EMC83267.1 - 8.4e-146 486.2 0.0 9.6e-146 486.0 0.0 1.0 1 0 0 1 1 1 1 CD36 family G-alpha PF00503.20 EMC83268.1 - 1.3e-120 402.8 2.2 1.7e-120 402.4 2.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EMC83268.1 - 1.4e-15 57.2 0.9 1.9e-11 43.7 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 EMC83268.1 - 0.0011 19.2 0.5 2 8.6 0.1 2.7 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 EMC83268.1 - 0.0031 16.9 0.0 0.0049 16.3 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein Gtr1_RagA PF04670.12 EMC83268.1 - 0.016 14.6 4.1 0.58 9.5 0.6 2.5 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region DAP3 PF10236.9 EMC83268.1 - 0.085 12.0 0.3 0.14 11.3 0.3 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 EMC83268.1 - 0.11 12.9 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 EMC83268.1 - 0.12 11.7 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.6 EMC83268.1 - 0.13 12.0 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain G-alpha PF00503.20 EMC83269.1 - 1.8e-114 382.6 2.3 2e-114 382.4 2.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EMC83269.1 - 1.3e-13 50.8 0.5 2.4e-10 40.1 0.3 3.2 2 1 0 2 2 2 1 ADP-ribosylation factor family DUF261 PF03196.13 EMC83269.1 - 0.033 14.3 0.2 2.6 8.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF261 PDZ PF00595.24 EMC83270.1 - 2.6e-61 203.9 10.0 3.5e-15 56.1 0.0 5.5 5 0 0 5 5 5 5 PDZ domain PDZ_6 PF17820.1 EMC83270.1 - 7.3e-49 163.4 13.1 3.1e-11 43.0 0.1 5.3 5 0 0 5 5 5 5 PDZ domain PDZ_2 PF13180.6 EMC83270.1 - 3.8e-25 88.0 0.2 4.1e-05 23.8 0.0 5.4 5 0 0 5 5 5 5 PDZ domain MAGI_u1 PF16663.5 EMC83270.1 - 3.4e-23 81.5 2.5 1.1e-22 79.8 2.5 2.0 1 0 0 1 1 1 1 Unstructured region on MAGI WW PF00397.26 EMC83270.1 - 3.5e-16 59.0 7.2 1.7e-09 37.6 0.3 3.2 3 0 0 3 3 3 2 WW domain Guanylate_kin PF00625.21 EMC83270.1 - 1.5e-08 34.5 0.0 2.6e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase Tricorn_PDZ PF14685.6 EMC83270.1 - 8e-07 28.9 2.2 1.8 8.6 0.0 5.0 5 0 0 5 5 5 2 Tricorn protease PDZ domain MAGI_u5 PF16666.5 EMC83270.1 - 0.00085 19.5 3.2 0.00085 19.5 3.2 4.8 5 0 0 5 5 5 1 Unstructured region on MAGI PDZ_4 PF17816.1 EMC83270.1 - 0.02 15.3 0.0 37 4.8 0.0 3.8 3 0 0 3 3 3 0 PDZ domain Phtf-FEM1B_bdg PF12129.8 EMC83271.1 - 2.6e-70 235.2 0.9 2.6e-70 235.2 0.9 2.0 2 1 1 3 3 3 1 Male germ-cell putative homeodomain transcription factor Tmemb_185A PF10269.9 EMC83272.1 - 1.8e-13 50.8 2.7 2.3e-13 50.4 2.7 1.2 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein DUF3522 PF12036.8 EMC83272.1 - 0.0058 16.9 3.4 0.0063 16.8 2.5 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3522) CoA_binding_3 PF13727.6 EMC83272.1 - 5.7 6.9 12.6 0.11 12.5 5.1 1.8 1 1 1 2 2 2 0 CoA-binding domain Y_phosphatase PF00102.27 EMC83273.1 - 1e-81 274.0 0.2 1.5e-81 273.5 0.2 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EMC83273.1 - 5.4e-05 23.3 0.0 9.1e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 EMC83273.1 - 0.013 15.3 0.0 0.028 14.2 0.0 1.6 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain UBN_AB PF14075.6 EMC83273.1 - 0.026 14.2 0.4 0.049 13.4 0.4 1.4 1 0 0 1 1 1 0 Ubinuclein conserved middle domain GSAP-16 PF14959.6 EMC83274.1 - 4.8e-41 139.0 0.1 1.8e-40 137.1 0.1 2.1 1 0 0 1 1 1 1 gamma-Secretase-activating protein C-term zinc-ribbon_6 PF10005.9 EMC83274.1 - 0.062 14.0 0.1 0.17 12.6 0.1 1.7 1 0 0 1 1 1 0 zinc-ribbon domain Med9 PF07544.13 EMC83275.1 - 0.013 15.6 0.3 0.013 15.6 0.3 11.6 7 3 3 11 11 11 0 RNA polymerase II transcription mediator complex subunit 9 p450 PF00067.22 EMC83276.1 - 2.9e-47 161.5 0.0 3.2e-47 161.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FF PF01846.19 EMC83276.1 - 1.2 9.4 0.1 1.2 9.4 0.1 2.4 3 0 0 3 3 3 0 FF domain RhoGAP PF00620.27 EMC83280.1 - 2.6e-07 30.6 0.1 3.2e-07 30.3 0.1 1.1 1 0 0 1 1 1 1 RhoGAP domain IRK_C PF17655.1 EMC83282.1 - 1e-66 223.8 0.0 1.3e-66 223.5 0.0 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 EMC83282.1 - 3.7e-34 117.6 7.6 6.2e-27 94.2 2.0 2.2 1 1 1 2 2 2 2 Inward rectifier potassium channel transmembrane domain DUF3938 PF13074.6 EMC83282.1 - 3.8 7.8 5.5 1.6 9.0 2.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3938) Calsequestrin PF01216.17 EMC83284.1 - 9.6e-159 528.5 43.4 4.1e-152 506.7 5.5 2.7 1 1 1 2 2 2 2 Calsequestrin Thioredoxin_6 PF13848.6 EMC83284.1 - 6.7e-20 71.8 3.1 5.3e-17 62.3 1.1 2.1 2 0 0 2 2 2 2 Thioredoxin-like domain SDA1 PF05285.12 EMC83284.1 - 0.15 11.4 15.4 0.22 10.9 15.4 1.3 1 0 0 1 1 1 0 SDA1 PPP4R2 PF09184.11 EMC83284.1 - 0.3 10.6 11.3 0.39 10.3 11.3 1.3 1 0 0 1 1 1 0 PPP4R2 BUD22 PF09073.10 EMC83284.1 - 1.1 8.5 8.9 1.3 8.2 8.9 1.3 1 0 0 1 1 1 0 BUD22 DED PF01335.21 EMC83285.1 - 1.1e-18 67.3 0.0 1.5e-18 66.8 0.0 1.2 1 0 0 1 1 1 1 Death effector domain FCD PF07729.12 EMC83285.1 - 0.089 13.2 0.2 0.3 11.5 0.2 1.8 1 1 0 1 1 1 0 FCD domain Pex19 PF04614.12 EMC83286.1 - 3.7e-10 40.0 0.0 4.4e-10 39.7 0.0 1.0 1 0 0 1 1 1 1 Pex19 protein family Complex1_49kDa PF00346.19 EMC83287.1 - 7.8e-39 133.4 0.0 8.6e-39 133.3 0.0 1.0 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit DUF1440 PF07274.12 EMC83288.1 - 0.12 12.8 0.0 24 5.3 0.0 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1440) Ribosomal_60s PF00428.19 EMC83289.1 - 5.5 7.6 11.8 4.1 8.1 10.7 1.4 1 1 0 1 1 1 0 60s Acidic ribosomal protein Myelin-PO_C PF10570.9 EMC83290.1 - 1.6e-29 102.1 8.3 2.3e-29 101.6 8.3 1.3 1 0 0 1 1 1 1 Myelin-PO cytoplasmic C-term p65 binding region V-set PF07686.17 EMC83290.1 - 9.2e-21 74.1 0.1 1.3e-20 73.6 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 EMC83290.1 - 1.3e-07 31.6 0.3 3.2e-07 30.4 0.3 1.6 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC83290.1 - 1.5e-07 31.7 0.5 1.6e-05 25.2 0.5 2.2 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC83290.1 - 1.4e-05 25.6 0.1 3.5e-05 24.3 0.1 1.7 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC83290.1 - 0.0023 17.9 0.1 0.0064 16.5 0.1 1.7 1 1 0 1 1 1 1 Immunoglobulin I-set domain Herpes_gE PF02480.16 EMC83290.1 - 0.019 13.7 1.6 0.43 9.3 1.6 2.0 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein E DUF202 PF02656.15 EMC83290.1 - 0.067 13.6 0.1 0.12 12.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Amnionless PF14828.6 EMC83290.1 - 0.067 12.0 0.0 0.085 11.7 0.0 1.1 1 0 0 1 1 1 0 Amnionless Lep_receptor_Ig PF06328.11 EMC83290.1 - 0.18 11.7 0.5 1.2 9.2 0.1 2.2 2 1 1 3 3 3 0 Ig-like C2-type domain Sdh_cyt PF01127.22 EMC83291.1 - 2.4e-20 72.8 3.1 2.3e-18 66.3 0.8 2.2 2 0 0 2 2 2 2 Succinate dehydrogenase/Fumarate reductase transmembrane subunit TPH PF13868.6 EMC83292.1 - 2.5e-64 217.0 133.9 2.5e-64 217.0 133.9 2.1 1 1 1 2 2 2 1 Trichohyalin-plectin-homology domain CH PF00307.31 EMC83293.1 - 4e-13 49.5 0.0 7.4e-13 48.6 0.0 1.4 1 1 1 2 2 2 1 Calponin homology (CH) domain Pentaxin PF00354.17 EMC83294.1 - 4.9e-75 251.5 0.0 5.5e-75 251.3 0.0 1.0 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.6 EMC83294.1 - 1e-06 29.0 0.0 1.2e-06 28.7 0.0 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily S_100 PF01023.19 EMC83295.1 - 8.8e-20 70.1 0.3 8.8e-20 70.1 0.3 1.7 2 0 0 2 2 2 1 S-100/ICaBP type calcium binding domain EF-hand_4 PF12763.7 EMC83295.1 - 1.5e-05 24.9 0.0 1.8e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.6 EMC83295.1 - 0.00016 22.0 0.2 0.00022 21.6 0.2 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EMC83295.1 - 0.0025 17.2 0.5 0.029 13.9 0.2 2.3 2 0 0 2 2 2 1 EF hand EF-hand_9 PF14658.6 EMC83295.1 - 0.11 12.8 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain S_100 PF01023.19 EMC83296.1 - 1.1e-11 44.3 0.1 1.6e-11 43.7 0.1 1.3 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_5 PF13202.6 EMC83296.1 - 3.8e-06 26.1 0.8 0.00027 20.3 0.1 2.4 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.32 EMC83296.1 - 4.2e-06 25.9 0.5 0.0015 17.9 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EMC83296.1 - 2e-05 24.9 0.3 7.8e-05 23.1 0.2 1.8 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 EMC83296.1 - 0.0003 20.6 0.2 0.001 18.9 0.1 1.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EMC83296.1 - 0.00058 19.6 0.3 1.1 9.4 0.0 2.6 2 1 0 2 2 2 2 EF-hand domain DUF5532 PF17673.1 EMC83296.1 - 0.042 13.9 0.1 0.062 13.4 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5532) DEK_C PF08766.11 EMC83296.1 - 0.11 12.4 0.2 0.28 11.1 0.2 1.8 1 1 0 1 1 1 0 DEK C terminal domain PDE4_UCR PF18100.1 EMC83296.1 - 0.16 12.6 1.2 0.38 11.4 1.2 1.7 1 1 0 1 1 1 0 Phosphodiesterase 4 upstream conserved regions (UCR) S_100 PF01023.19 EMC83297.1 - 5.1e-10 38.9 0.7 7.8e-10 38.3 0.0 1.7 2 0 0 2 2 2 1 S-100/ICaBP type calcium binding domain S_100 PF01023.19 EMC83298.1 - 4.1e-22 77.6 1.5 6.1e-22 77.1 1.5 1.3 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.32 EMC83298.1 - 1.7e-07 30.3 0.5 4.8e-06 25.7 0.1 2.3 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 EMC83298.1 - 1.8e-06 28.3 0.3 2.5e-06 27.8 0.3 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EMC83298.1 - 0.00011 21.5 2.5 0.0018 17.7 0.1 2.2 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 EMC83298.1 - 0.00025 20.7 0.1 0.28 11.2 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 EMC83298.1 - 0.016 15.0 0.7 0.058 13.3 0.6 2.0 1 1 1 2 2 2 0 EF-hand domain pair Sigma54_CBD PF04963.13 EMC83298.1 - 0.061 13.2 0.1 0.081 12.8 0.1 1.2 1 0 0 1 1 1 0 Sigma-54 factor, core binding domain EF-hand_4 PF12763.7 EMC83298.1 - 0.072 13.0 0.0 0.086 12.8 0.0 1.2 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand DEK_C PF08766.11 EMC83298.1 - 0.12 12.3 0.4 0.2 11.6 0.4 1.5 1 1 0 1 1 1 0 DEK C terminal domain FoP_duplication PF13865.6 EMC83299.1 - 4.5e-22 78.4 4.5 4.5e-22 78.4 4.5 2.8 1 1 2 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 DUF5320 PF17253.2 EMC83299.1 - 0.018 16.1 6.4 0.018 16.1 6.4 3.2 1 1 2 3 3 3 0 Family of unknown function (DUF5320) Sbi-IV PF11621.8 EMC83299.1 - 0.25 11.7 9.8 6.3 7.2 0.0 3.9 2 2 2 4 4 4 0 C3 binding domain 4 of IgG-bind protein SBI DZF PF07528.14 EMC83301.1 - 6.7e-96 320.7 0.0 8.6e-96 320.3 0.0 1.1 1 0 0 1 1 1 1 DZF domain SMODS PF18144.1 EMC83301.1 - 0.041 14.1 0.0 0.064 13.4 0.0 1.4 1 0 0 1 1 1 0 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain NTP_transf_2 PF01909.23 EMC83301.1 - 0.11 12.8 0.0 0.41 11.0 0.0 2.0 2 0 0 2 2 2 0 Nucleotidyltransferase domain Tli4_N PF18443.1 EMC83302.1 - 0.089 13.2 0.1 0.14 12.5 0.1 1.3 1 0 0 1 1 1 0 Tle cognate immunity protein 4 N-terminal domain SYS1 PF09801.9 EMC83303.1 - 3.3e-06 27.3 18.0 4.3e-06 26.9 18.0 1.2 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network MBT PF02820.18 EMC83304.1 - 5.7e-94 308.5 5.8 5.5e-31 106.7 0.1 3.4 3 0 0 3 3 3 3 mbt repeat SAM_1 PF00536.30 EMC83304.1 - 7.1e-15 55.2 0.0 1.2e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-C2HC PF01530.18 EMC83304.1 - 3.9e-08 33.3 7.4 9.7e-08 32.1 7.4 1.7 1 0 0 1 1 1 1 Zinc finger, C2HC type SAM_2 PF07647.17 EMC83304.1 - 2e-06 27.8 0.0 3.5e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Calci_bind_CcbP PF11535.8 EMC83304.1 - 0.076 13.5 0.1 0.83 10.2 0.0 2.5 2 0 0 2 2 2 0 Calcium binding SAM_1 PF00536.30 EMC83305.1 - 1.9e-11 44.2 0.3 8.5e-11 42.1 0.1 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC83305.1 - 6e-09 35.9 0.2 2.4e-08 33.9 0.0 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) DUF2371 PF10177.9 EMC83306.1 - 1.3e-60 203.6 0.0 2.3e-60 202.8 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2371) RbcS PF12338.8 EMC83306.1 - 0.0075 16.4 0.2 0.029 14.5 0.2 2.1 1 0 0 1 1 1 1 Ribulose-1,5-bisphosphate carboxylase small subunit DUF202 PF02656.15 EMC83306.1 - 0.13 12.7 0.1 11 6.5 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF202) 4_1_CTD PF05902.13 EMC83308.1 - 1.7e-49 166.3 10.7 1.7e-49 166.3 10.7 3.1 3 0 0 3 3 3 1 4.1 protein C-terminal domain (CTD) FERM_C PF09380.10 EMC83308.1 - 1.1e-24 86.6 0.0 2.6e-24 85.4 0.0 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain SAB PF04382.13 EMC83308.1 - 5.7e-23 80.7 1.9 5.7e-23 80.7 1.9 2.6 2 0 0 2 2 2 1 SAB domain FERM_N PF09379.10 EMC83308.1 - 6.3e-20 70.9 0.4 1.9e-19 69.3 0.2 2.0 2 0 0 2 2 2 1 FERM N-terminal domain FERM_M PF00373.18 EMC83308.1 - 1.4e-19 70.6 0.1 1.4e-19 70.6 0.1 3.1 3 1 0 3 3 3 1 FERM central domain FA PF08736.11 EMC83308.1 - 3.2e-18 65.5 4.5 1.5e-17 63.4 4.5 2.3 1 0 0 1 1 1 1 FERM adjacent (FA) SR-25 PF10500.9 EMC83308.1 - 0.0064 16.1 8.5 0.0064 16.1 8.5 3.4 2 1 1 3 3 3 1 Nuclear RNA-splicing-associated protein AKAP7_NLS PF10469.9 EMC83309.1 - 9.6e-45 153.0 0.5 1.3e-44 152.6 0.5 1.2 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain AKAP7_RIRII_bdg PF10470.9 EMC83309.1 - 2e-35 120.6 3.3 4.5e-35 119.5 3.3 1.6 1 0 0 1 1 1 1 PKA-RI-RII subunit binding domain of A-kinase anchor protein 2_5_RNA_ligase2 PF13563.6 EMC83309.1 - 1.4e-06 28.3 0.1 3e-06 27.2 0.0 1.5 2 0 0 2 2 2 1 2'-5' RNA ligase superfamily Corona_NS2A PF05213.12 EMC83309.1 - 0.00017 21.0 0.2 0.0021 17.4 0.2 2.0 1 1 0 1 1 1 1 Coronavirus NS2A protein LigT_PEase PF02834.16 EMC83309.1 - 0.0062 16.7 0.1 2.5 8.4 0.0 2.7 3 0 0 3 3 3 2 LigT like Phosphoesterase MutS_V PF00488.21 EMC83310.1 - 1.1e-45 156.0 0.0 2.2e-45 155.0 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EMC83310.1 - 2.6e-25 89.8 0.5 4.6e-25 89.0 0.5 1.4 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 EMC83310.1 - 4.9e-13 49.2 0.0 9.8e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 MutS family domain IV AAA_14 PF13173.6 EMC83310.1 - 0.12 12.4 0.1 0.36 10.9 0.1 1.8 1 1 0 1 1 1 0 AAA domain Med23 PF11573.8 EMC83311.1 - 0 2013.1 10.0 0 2012.9 10.0 1.0 1 0 0 1 1 1 1 Mediator complex subunit 23 Phosphodiest PF01663.22 EMC83312.1 - 1.6e-83 281.3 0.1 2e-83 280.9 0.1 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Somatomedin_B PF01033.17 EMC83312.1 - 3.8e-17 62.4 39.3 4.3e-09 36.6 16.3 2.8 2 0 0 2 2 2 2 Somatomedin B domain Endonuclease_NS PF01223.23 EMC83312.1 - 8.6e-12 45.4 0.2 1.5e-11 44.5 0.2 1.3 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Metalloenzyme PF01676.18 EMC83312.1 - 1.3e-05 24.7 0.0 2.2e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 EMC83312.1 - 0.0069 15.8 0.1 0.43 9.9 0.1 2.4 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EMC83313.1 - 4.9e-83 279.7 0.0 6.3e-83 279.3 0.0 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Somatomedin_B PF01033.17 EMC83313.1 - 2.8e-15 56.4 47.3 2.1e-08 34.4 15.0 3.1 3 0 0 3 3 3 2 Somatomedin B domain Endonuclease_NS PF01223.23 EMC83313.1 - 3.3e-09 36.9 0.2 7.4e-09 35.8 0.2 1.5 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Sulfatase PF00884.23 EMC83313.1 - 0.0011 18.4 0.0 0.047 13.1 0.0 2.2 1 1 0 1 1 1 1 Sulfatase Cys_knot PF00007.22 EMC83314.1 - 1.5e-16 60.6 10.5 1.5e-16 60.6 10.5 3.1 3 1 0 3 3 3 1 Cystine-knot domain VWC PF00093.18 EMC83314.1 - 4.2e-10 39.8 9.9 4.2e-10 39.8 9.9 3.9 2 1 0 2 2 2 1 von Willebrand factor type C domain TSP_1 PF00090.19 EMC83314.1 - 7.2e-06 26.1 6.2 7.2e-06 26.1 6.2 3.1 2 0 0 2 2 2 1 Thrombospondin type 1 domain Cu2_monooxygen PF01082.20 EMC83315.1 - 1.1e-49 168.0 1.2 2.4e-49 166.9 1.2 1.6 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain Cu2_monoox_C PF03712.15 EMC83315.1 - 9.2e-43 145.5 0.0 1.8e-42 144.5 0.0 1.5 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain DOMON PF03351.17 EMC83315.1 - 8.7e-12 45.4 0.4 1.5e-11 44.5 0.4 1.4 1 0 0 1 1 1 1 DOMON domain DUF1987 PF09345.10 EMC83315.1 - 0.16 11.6 0.2 0.9 9.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1987) DUF5427 PF10310.9 EMC83316.1 - 6.7 5.5 0.0 6.7 5.5 0.0 4.4 3 1 1 4 4 4 0 Family of unknown function (DUF5427) Syntaxin_2 PF14523.6 EMC83317.1 - 4.6e-30 104.0 17.1 2.2e-28 98.6 9.5 2.1 2 0 0 2 2 2 2 Syntaxin-like protein SNARE PF05739.19 EMC83317.1 - 8.6e-19 67.3 1.3 2.3e-18 65.9 1.3 1.8 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 EMC83317.1 - 9.5e-11 41.7 11.5 9.5e-11 41.7 11.5 2.3 2 1 0 2 2 2 1 Syntaxin Synaptobrevin PF00957.21 EMC83317.1 - 0.019 14.8 3.0 0.019 14.8 3.0 2.5 2 1 0 2 2 2 0 Synaptobrevin DUF3040 PF11239.8 EMC83317.1 - 0.027 14.7 0.3 0.18 12.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) CCDC-167 PF15188.6 EMC83317.1 - 0.034 14.5 15.0 0.12 12.8 1.6 3.2 2 2 1 3 3 3 0 Coiled-coil domain-containing protein 167 T3SS_needle_E PF08988.10 EMC83317.1 - 0.036 14.2 0.3 0.036 14.2 0.3 3.7 4 1 1 5 5 5 0 Type III secretion system, cytoplasmic E component of needle DASH_Dad4 PF08650.10 EMC83317.1 - 0.036 14.0 4.7 0.46 10.5 0.1 2.9 2 1 1 3 3 3 0 DASH complex subunit Dad4 VIT1 PF01988.19 EMC83317.1 - 0.45 10.3 1.7 4.7 7.0 0.1 2.2 2 0 0 2 2 2 0 VIT family Cep57_CLD_2 PF14197.6 EMC83317.1 - 1.1 9.4 9.2 0.93 9.6 0.2 2.9 3 1 0 3 3 3 0 Centrosome localisation domain of PPC89 FUSC PF04632.12 EMC83317.1 - 1.8 7.0 6.3 0.78 8.2 3.2 1.7 1 1 1 2 2 2 0 Fusaric acid resistance protein family ABC_tran_CTD PF16326.5 EMC83317.1 - 2.7 8.3 19.1 10 6.4 1.2 4.3 2 2 2 4 4 4 0 ABC transporter C-terminal domain Spore_III_AB PF09548.10 EMC83317.1 - 3.3 7.8 9.3 1.6 8.8 0.3 2.7 2 1 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) IZUMO PF15005.6 EMC83317.1 - 3.6 8.1 6.8 2.2 8.8 1.9 2.6 2 2 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated PCRF PF03462.18 EMC83317.1 - 4.8 7.0 11.0 2.7 7.8 2.0 2.3 2 1 0 2 2 2 0 PCRF domain Enkurin PF13864.6 EMC83317.1 - 5.3 7.6 9.9 1.4 9.4 1.9 3.0 2 1 0 2 2 2 0 Calmodulin-binding FapA PF03961.13 EMC83317.1 - 5.5 5.5 9.9 0.44 9.1 1.6 2.1 2 0 0 2 2 2 0 Flagellar Assembly Protein A CN_hydrolase PF00795.22 EMC83318.1 - 1e-21 77.5 0.0 1.3e-21 77.1 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Sec10 PF07393.11 EMC83318.1 - 0.064 11.7 0.0 0.085 11.3 0.0 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec10 CN_hydrolase PF00795.22 EMC83319.1 - 2e-20 73.3 0.0 2.9e-20 72.7 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase MFS_1 PF07690.16 EMC83320.1 - 1e-38 133.2 70.4 1.5e-23 83.3 35.5 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EMC83320.1 - 2.4e-05 23.4 26.0 0.018 13.9 3.8 3.4 1 1 1 2 2 2 2 MFS_1 like family LacY_symp PF01306.19 EMC83320.1 - 0.0017 17.2 14.9 0.084 11.6 0.1 2.4 1 1 1 2 2 2 2 LacY proton/sugar symporter DUF4112 PF13430.6 EMC83320.1 - 0.38 11.1 4.7 0.96 9.7 0.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4112) Phage_holin_2_3 PF16080.5 EMC83320.1 - 0.49 10.2 6.5 1.3 8.8 0.2 3.6 3 0 0 3 3 3 0 Bacteriophage holin family HP1 Ribosomal_L7Ae PF01248.26 EMC83321.1 - 4.4e-30 103.3 1.9 5.4e-30 103.0 1.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DEPP PF15343.6 EMC83322.1 - 1.8 8.6 11.2 2.2 8.3 11.2 1.2 1 0 0 1 1 1 0 Decidual protein induced by progesterone family Nop14 PF04147.12 EMC83322.1 - 2.9 6.0 55.0 3.2 5.9 55.0 1.0 1 0 0 1 1 1 0 Nop14-like family Hydrolase PF00702.26 EMC83323.1 - 6.3e-07 29.9 0.0 8.5e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HLH PF00010.26 EMC83324.1 - 7.5e-16 57.8 0.2 1.1e-15 57.3 0.2 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain TBP PF00352.21 EMC83325.1 - 3.6e-45 151.8 0.4 8e-23 80.2 0.1 2.0 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EMC83325.1 - 0.0019 18.3 0.0 0.013 15.6 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3378) Sugar_tr PF00083.24 EMC83326.1 - 3.7e-102 342.5 26.8 1.5e-77 261.4 14.4 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EMC83326.1 - 9.3e-28 97.1 35.5 7.1e-25 87.7 21.7 2.6 2 1 0 2 2 2 2 Major Facilitator Superfamily Phage_holin_2_3 PF16080.5 EMC83326.1 - 0.0017 18.1 3.0 0.41 10.4 0.0 3.3 2 0 0 2 2 2 2 Bacteriophage holin family HP1 Pkinase PF00069.25 EMC83327.1 - 1e-65 221.7 0.0 1.4e-65 221.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC83327.1 - 4.4e-31 108.1 0.0 8.4e-31 107.2 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC83327.1 - 3.5e-07 29.8 0.0 1.6e-06 27.6 0.0 1.9 1 1 1 2 2 2 1 Kinase-like Pkinase_C PF00433.24 EMC83327.1 - 3.6e-06 27.6 0.1 3.6e-06 27.6 0.1 1.7 2 0 0 2 2 2 1 Protein kinase C terminal domain FTA2 PF13095.6 EMC83327.1 - 0.003 17.2 0.2 0.91 9.1 0.2 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EMC83327.1 - 0.0037 16.6 0.0 0.006 16.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EMC83327.1 - 0.05 12.6 0.0 0.088 11.7 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain PX PF00787.24 EMC83327.1 - 0.06 13.3 0.1 0.18 11.8 0.0 1.8 2 0 0 2 2 2 0 PX domain Pacs-1 PF10254.9 EMC83327.1 - 0.17 10.8 0.1 0.26 10.2 0.1 1.3 1 0 0 1 1 1 0 PACS-1 cytosolic sorting protein Aldedh PF00171.22 EMC83328.1 - 2.3e-172 573.7 0.0 2.7e-172 573.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family 120_Rick_ant PF12574.8 EMC83328.1 - 0.17 11.1 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 120 KDa Rickettsia surface antigen DUF4487 PF14868.6 EMC83328.1 - 0.19 10.5 0.0 0.28 10.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4487) GTP_EFTU PF00009.27 EMC83329.1 - 5.7e-48 163.0 0.0 1.1e-47 162.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EMC83329.1 - 1.8e-28 99.1 0.7 6.7e-28 97.2 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain HBS1_N PF08938.10 EMC83329.1 - 1.3e-20 73.5 0.5 2.9e-20 72.3 0.5 1.6 1 0 0 1 1 1 1 HBS1 N-terminus GTP_EFTU_D2 PF03144.25 EMC83329.1 - 2.5e-07 31.0 0.2 1.1e-06 29.0 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EMC83329.1 - 3e-07 30.5 0.7 6.5e-05 23.0 0.1 3.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EMC83329.1 - 0.004 17.4 0.0 0.017 15.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain DUF1296 PF06972.11 EMC83329.1 - 0.017 15.2 0.4 0.042 14.0 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) AAA_29 PF13555.6 EMC83329.1 - 0.9 9.3 2.8 1.3 8.8 0.0 2.7 3 0 0 3 3 3 0 P-loop containing region of AAA domain Cmyb_C PF09316.10 EMC83330.1 - 1.5e-69 232.9 2.9 2.8e-69 232.0 2.9 1.5 1 0 0 1 1 1 1 C-myb, C-terminal Myb_DNA-binding PF00249.31 EMC83330.1 - 9.3e-52 173.0 20.3 6.5e-18 64.7 1.9 3.9 4 0 0 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EMC83330.1 - 2.9e-40 136.3 16.8 3e-17 62.6 1.9 3.5 1 1 2 3 3 3 3 Myb-like DNA-binding domain LMSTEN PF07988.12 EMC83330.1 - 9.7e-27 92.2 0.6 2.1e-26 91.1 0.6 1.6 1 0 0 1 1 1 1 LMSTEN motif Myb_DNA-bind_7 PF15963.5 EMC83330.1 - 6.2e-09 35.6 8.2 0.00038 20.3 0.1 3.9 2 1 2 4 4 4 2 Myb DNA-binding like SLIDE PF09111.10 EMC83330.1 - 1.4e-06 28.3 0.2 1.3 9.1 0.0 4.0 2 1 2 4 4 4 3 SLIDE SANT_DAMP1_like PF16282.5 EMC83330.1 - 0.00012 22.2 3.6 0.35 11.1 0.0 3.4 1 1 1 3 3 3 2 SANT/Myb-like domain of DAMP1 Rap1_C PF11626.8 EMC83330.1 - 0.13 12.4 8.3 3 8.0 1.0 3.5 1 1 2 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Spore_III_AB PF09548.10 EMC83330.1 - 0.92 9.6 3.5 0.83 9.7 0.0 2.6 2 1 0 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) WD40 PF00400.32 EMC83331.1 - 4.5e-23 81.1 9.1 4.1e-08 33.8 0.1 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat SH3_1 PF00018.28 EMC83331.1 - 5.7e-17 61.1 0.0 1.6e-16 59.7 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC83331.1 - 7.4e-14 51.3 0.0 1.7e-13 50.2 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC83331.1 - 8.9e-11 41.3 0.0 2.3e-10 40.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain ANAPC4_WD40 PF12894.7 EMC83331.1 - 9.7e-08 32.2 0.0 0.6 10.4 0.0 5.2 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain DUF4648 PF15505.6 EMC83331.1 - 2e-06 28.6 0.0 6.8e-06 26.9 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4648) PDEase_I PF00233.19 EMC83332.1 - 9.1e-76 254.7 0.6 1.2e-75 254.3 0.6 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Mito_fiss_reg PF05308.11 EMC83333.1 - 1.1e-72 245.2 0.1 1.5e-72 244.7 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial fission regulator THRAP3_BCLAF1 PF15440.6 EMC83334.1 - 1.5e-186 622.4 105.5 1.5e-186 622.4 105.5 2.6 2 1 1 3 3 3 1 THRAP3/BCLAF1 family Arm PF00514.23 EMC83335.1 - 0.044 13.8 0.1 1 9.5 0.0 2.7 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat mRNA_stabil PF13929.6 EMC83335.1 - 0.059 12.4 0.4 0.12 11.3 0.4 1.6 1 1 0 1 1 1 0 mRNA stabilisation IDO PF01231.18 EMC83335.1 - 0.11 11.3 0.1 0.13 11.0 0.1 1.1 1 0 0 1 1 1 0 Indoleamine 2,3-dioxygenase MAP7 PF05672.11 EMC83336.1 - 4.2e-43 146.8 83.4 4.2e-43 146.8 83.4 3.8 3 1 0 3 3 3 1 MAP7 (E-MAP-115) family WD40 PF00400.32 EMC83337.1 - 1.6e-20 73.0 12.7 0.0032 18.3 0.0 5.4 5 0 0 5 5 5 5 WD domain, G-beta repeat eIF2A PF08662.11 EMC83337.1 - 7e-05 22.8 0.1 0.00069 19.5 0.0 2.0 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 EMC83337.1 - 0.082 13.2 1.1 1.8 8.9 0.1 2.8 1 1 3 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain DUF4199 PF13858.6 EMC83338.1 - 0.0018 18.7 0.3 0.036 14.5 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF4199) SpoIIIAH PF12685.7 EMC83338.1 - 0.019 14.8 1.6 0.028 14.3 1.6 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein EamA PF00892.20 EMC83338.1 - 0.027 14.7 11.5 0.033 14.4 11.5 1.1 1 0 0 1 1 1 0 EamA-like transporter family DUF3951 PF13131.6 EMC83338.1 - 0.041 14.1 0.2 0.15 12.2 0.2 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3951) NnrU PF07298.11 EMC83338.1 - 0.16 11.4 1.5 0.24 10.9 1.1 1.6 1 1 0 1 1 1 0 NnrU protein VIT1 PF01988.19 EMC83338.1 - 0.5 10.2 5.4 0.071 13.0 0.8 1.8 1 1 1 2 2 2 0 VIT family DUF2070 PF09843.9 EMC83338.1 - 0.58 8.4 6.8 0.71 8.1 6.8 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) 7TMR-DISM_7TM PF07695.11 EMC83338.1 - 4.1 7.3 10.6 4.7 7.1 8.3 1.7 1 1 1 2 2 2 0 7TM diverse intracellular signalling Tissue_fac PF01108.17 EMC83339.1 - 2e-26 91.9 0.2 5.4e-26 90.5 0.2 1.8 1 0 0 1 1 1 1 Tissue factor Interfer-bind PF09294.10 EMC83339.1 - 1.1e-19 70.7 1.6 2.3e-19 69.6 0.1 2.3 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III Tissue_fac PF01108.17 EMC83340.1 - 3.9e-29 100.6 1.8 1.4e-28 98.9 1.8 1.9 1 1 0 1 1 1 1 Tissue factor Interfer-bind PF09294.10 EMC83340.1 - 5.7e-19 68.4 0.5 1.3e-18 67.3 0.1 1.7 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III Ribosom_S12_S23 PF00164.25 EMC83340.1 - 0.095 12.3 0.0 0.76 9.4 0.0 2.1 3 0 0 3 3 3 0 Ribosomal protein S12/S23 Tissue_fac PF01108.17 EMC83341.1 - 8.1e-19 67.5 0.3 9.6e-19 67.2 0.3 1.1 1 0 0 1 1 1 1 Tissue factor HLH PF00010.26 EMC83342.1 - 3.3e-12 46.2 0.3 6.2e-12 45.3 0.3 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain zf-A20 PF01754.16 EMC83343.1 - 2.5e-35 120.0 76.3 1.5e-08 34.4 2.9 7.9 8 0 0 8 8 8 7 A20-like zinc finger OTU PF02338.19 EMC83343.1 - 2.1e-30 105.8 0.0 7e-30 104.1 0.0 1.9 1 0 0 1 1 1 1 OTU-like cysteine protease MscS_porin PF12795.7 EMC83343.1 - 0.3 10.6 7.5 0.63 9.5 7.5 1.5 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain PMP22_Claudin PF00822.20 EMC83344.1 - 1.2e-08 35.0 9.5 1.5e-08 34.7 9.5 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family L_HMGIC_fpl PF10242.9 EMC83344.1 - 0.0011 19.2 7.0 0.0027 18.0 7.0 1.7 1 1 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein PalH PF08733.10 EMC83344.1 - 0.0072 15.4 1.6 0.0088 15.1 1.6 1.1 1 0 0 1 1 1 1 PalH/RIM21 PTR2 PF00854.21 EMC83344.1 - 0.24 10.2 8.5 0.84 8.4 1.3 2.2 1 1 1 2 2 2 0 POT family Pox_A14 PF05767.12 EMC83344.1 - 0.62 10.3 8.2 0.17 12.0 4.6 1.8 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 SUR7 PF06687.12 EMC83344.1 - 7.8 6.1 16.4 2.2 7.8 13.4 1.6 1 1 1 2 2 2 0 SUR7/PalI family PMP22_Claudin PF00822.20 EMC83345.1 - 5.3e-11 42.7 3.7 7.7e-11 42.2 3.7 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family L_HMGIC_fpl PF10242.9 EMC83345.1 - 0.0004 20.6 5.9 0.0011 19.2 5.9 1.7 1 1 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein Pox_A14 PF05767.12 EMC83345.1 - 1.1 9.4 8.3 1.4 9.1 4.6 2.3 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 NHS PF15273.6 EMC83346.1 - 2.9e-271 902.2 84.0 2.9e-271 902.2 84.0 2.7 3 0 0 3 3 3 1 NHS-like DUF4061 PF13270.6 EMC83347.1 - 2.1e-32 111.3 2.8 2.9e-32 110.8 2.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4061) EF-hand_4 PF12763.7 EMC83348.1 - 1.7e-12 47.2 0.6 4.2e-12 45.9 0.0 2.0 3 0 0 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EMC83348.1 - 0.0012 18.3 0.0 0.0028 17.1 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 EMC83348.1 - 0.0056 16.5 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 EMC83348.1 - 0.01 16.3 0.0 0.022 15.2 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EMC83348.1 - 0.031 14.2 0.0 0.093 12.7 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain Costars PF14705.6 EMC83349.1 - 1.6e-30 105.1 0.2 1.7e-30 105.0 0.2 1.0 1 0 0 1 1 1 1 Costars Arf PF00025.21 EMC83350.1 - 4.4e-60 202.1 0.1 5.1e-60 201.9 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EMC83350.1 - 5.7e-14 52.4 0.0 7.6e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EMC83350.1 - 1.5e-12 47.3 0.0 1.8e-12 47.1 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EMC83350.1 - 6.1e-12 45.4 1.0 6.1e-08 32.2 0.1 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EMC83350.1 - 1.1e-10 41.4 0.0 1.3e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EMC83350.1 - 1.4e-09 37.7 0.0 1.6e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMC83350.1 - 4.1e-06 26.9 0.0 5.4e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EMC83350.1 - 0.0028 17.0 0.6 0.011 15.1 0.6 1.8 1 1 0 1 1 1 1 6-phosphofructo-2-kinase AAA_33 PF13671.6 EMC83350.1 - 0.16 12.1 0.3 0.35 11.0 0.3 1.8 1 1 0 1 1 1 0 AAA domain RhoGEF PF00621.20 EMC83351.1 - 3.8e-38 131.5 0.1 7.4e-38 130.6 0.1 1.5 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 EMC83351.1 - 0.00098 19.6 0.0 0.0022 18.4 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_5 PF15405.6 EMC83351.1 - 0.0053 16.9 0.1 0.049 13.7 0.1 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH_16 PF17838.1 EMC83351.1 - 0.025 14.4 0.1 6.6 6.6 0.0 2.4 2 0 0 2 2 2 0 PH domain zf-Di19 PF05605.12 EMC83351.1 - 0.37 11.1 2.6 0.37 11.1 0.4 2.1 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF3715 PF12509.8 EMC83352.1 - 8.5e-55 184.9 0.0 2.7e-54 183.3 0.0 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3715) CCDC66 PF15236.6 EMC83353.1 - 8.7e-48 162.0 31.8 8.7e-48 162.0 31.8 4.9 5 0 0 5 5 5 1 Coiled-coil domain-containing protein 66 Myosin_tail_1 PF01576.19 EMC83354.1 - 0.0004 18.4 1.2 0.00045 18.2 1.2 1.0 1 0 0 1 1 1 1 Myosin tail THP2 PF09432.10 EMC83354.1 - 0.099 12.7 0.1 0.17 12.0 0.1 1.3 1 0 0 1 1 1 0 Tho complex subunit THP2 DUF3496 PF12001.8 EMC83354.1 - 0.12 12.7 1.6 0.22 11.9 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3496) PRKG1_interact PF15898.5 EMC83354.1 - 0.28 12.1 4.6 0.49 11.3 4.6 1.4 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Caveolin PF01146.17 EMC83355.1 - 1.6e-58 196.4 1.9 1.8e-58 196.2 1.9 1.0 1 0 0 1 1 1 1 Caveolin 7tm_1 PF00001.21 EMC83356.1 - 2.1e-39 135.5 14.8 2.3e-39 135.3 14.8 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC83356.1 - 0.00093 18.6 11.5 0.0014 18.0 11.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx SAP PF02037.27 EMC83357.1 - 6.3e-11 41.8 0.3 6.3e-11 41.8 0.3 2.1 3 0 0 3 3 3 1 SAP domain zf-C3HC4_2 PF13923.6 EMC83357.1 - 2.2e-10 40.2 13.5 3.1e-10 39.7 9.2 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EMC83357.1 - 2.6e-08 33.6 7.1 5.4e-08 32.6 3.9 2.3 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4 PF00097.25 EMC83357.1 - 8.2e-07 28.8 15.8 1.2e-06 28.3 11.1 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC83357.1 - 3.5e-06 27.2 13.9 4.5e-06 26.9 9.5 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 EMC83357.1 - 4.5e-06 26.4 10.4 3.8e-05 23.5 6.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC83357.1 - 8.9e-06 25.6 7.9 8.9e-06 25.6 7.9 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMC83357.1 - 2.7e-05 24.0 10.1 2.7e-05 24.0 10.1 2.4 2 0 0 2 2 2 1 zinc-RING finger domain Mob_synth_C PF06463.13 EMC83357.1 - 0.0038 17.2 1.6 0.0038 17.2 1.6 2.6 3 0 0 3 3 3 1 Molybdenum Cofactor Synthesis C zf-WRNIP1_ubi PF18279.1 EMC83357.1 - 0.011 16.3 1.1 0.036 14.7 0.0 2.5 2 0 0 2 2 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-CpG_bind_C PF12269.8 EMC83357.1 - 0.013 15.3 0.0 0.013 15.3 0.0 2.2 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain zf-RING_10 PF16685.5 EMC83357.1 - 0.018 15.2 3.1 0.018 15.2 3.1 2.2 3 0 0 3 3 2 0 zinc RING finger of MSL2 LEM PF03020.15 EMC83357.1 - 0.026 14.1 0.2 0.057 13.0 0.2 1.5 1 0 0 1 1 1 0 LEM domain zf-rbx1 PF12678.7 EMC83357.1 - 0.057 13.7 12.6 0.052 13.8 9.2 2.6 2 1 0 2 2 2 0 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EMC83357.1 - 0.18 12.0 15.5 0.079 13.1 11.7 2.2 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 EMC83357.1 - 0.73 9.9 5.6 2.4 8.3 5.6 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger RNF220 PF15926.5 EMC83357.1 - 3.4 7.2 9.6 1.2 8.8 5.4 2.3 2 1 0 2 2 2 0 E3 ubiquitin-protein ligase RNF220 VHL_C PF17211.3 EMC83358.1 - 1.5e-30 104.9 3.2 2.2e-30 104.4 3.2 1.2 1 0 0 1 1 1 1 VHL box domain VHL PF01847.16 EMC83358.1 - 3.3e-10 39.7 0.0 8.3e-10 38.4 0.0 1.6 2 1 0 2 2 2 1 VHL beta domain STAT2_C PF12188.8 EMC83358.1 - 0.049 13.6 0.1 0.097 12.6 0.1 1.5 1 0 0 1 1 1 0 Signal transducer and activator of transcription 2 C terminal Motilin_assoc PF04643.12 EMC83359.1 - 7.6e-23 80.1 0.1 1.4e-22 79.3 0.1 1.5 1 0 0 1 1 1 1 Motilin/ghrelin-associated peptide Motilin_ghrelin PF04644.12 EMC83359.1 - 0.0003 20.5 1.4 0.00044 20.0 1.4 1.3 1 0 0 1 1 1 1 Motilin/ghrelin WD40 PF00400.32 EMC83360.1 - 4.2e-23 81.2 21.2 0.00053 20.7 0.2 6.6 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC83360.1 - 1.7e-07 31.5 4.8 0.017 15.4 0.0 4.7 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMC83360.1 - 0.018 14.0 1.4 0.91 8.4 0.0 2.8 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein TIP120 PF08623.10 EMC83361.1 - 4.4e-60 202.3 8.6 1.4e-59 200.6 0.3 4.9 5 1 1 6 6 6 1 TATA-binding protein interacting (TIP20) HEAT PF02985.22 EMC83361.1 - 3.9e-22 76.4 22.4 0.21 12.0 0.3 13.6 15 0 0 15 15 14 5 HEAT repeat HEAT_2 PF13646.6 EMC83361.1 - 1.4e-21 76.7 6.7 0.0028 18.0 0.0 9.9 9 1 1 10 10 10 4 HEAT repeats HEAT_EZ PF13513.6 EMC83361.1 - 2.3e-18 66.3 14.6 0.0021 18.5 0.1 13.0 12 3 4 16 16 16 4 HEAT-like repeat Cnd1 PF12717.7 EMC83361.1 - 1.1e-11 45.1 10.2 0.061 13.4 0.1 7.7 5 3 2 8 8 8 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EMC83361.1 - 1.6e-09 36.9 16.8 0.008 14.8 3.5 6.3 3 3 1 5 5 5 3 Adaptin N terminal region UME PF08064.13 EMC83361.1 - 2.7e-08 33.6 6.7 0.28 11.1 0.0 7.6 7 3 1 8 8 8 2 UME (NUC010) domain DUF3385 PF11865.8 EMC83361.1 - 4.3e-06 26.7 0.9 0.0013 18.6 0.1 5.0 3 2 0 3 3 3 1 Domain of unknown function (DUF3385) Vac14_Fab1_bd PF12755.7 EMC83361.1 - 9.1e-06 26.2 1.9 16 6.2 0.0 7.5 9 2 2 11 11 7 0 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EMC83361.1 - 1.2e-05 25.0 6.1 0.098 12.2 0.0 6.7 7 3 2 9 9 9 1 CLASP N terminal RTP1_C1 PF10363.9 EMC83361.1 - 2e-05 24.7 10.6 2.4 8.4 0.1 7.1 7 0 0 7 7 7 1 Required for nuclear transport of RNA pol II C-terminus 1 DRIM PF07539.12 EMC83361.1 - 2.1e-05 23.1 13.6 0.098 10.9 0.1 5.6 3 1 2 5 5 5 3 Down-regulated in metastasis Cnd3 PF12719.7 EMC83361.1 - 0.00032 20.0 15.0 0.57 9.3 0.1 6.1 4 3 1 6 6 6 2 Nuclear condensing complex subunits, C-term domain Arm PF00514.23 EMC83361.1 - 0.00086 19.3 6.1 5.6 7.2 0.0 6.9 7 0 0 7 7 6 1 Armadillo/beta-catenin-like repeat Telomere_reg-2 PF10193.9 EMC83361.1 - 0.0024 18.3 11.6 1.2 9.7 0.0 6.2 9 0 0 9 9 5 1 Telomere length regulation protein DUF1981 PF09324.10 EMC83361.1 - 0.0051 16.6 0.0 9.7 6.1 0.0 4.9 4 0 0 4 4 4 0 Domain of unknown function (DUF1981) API5 PF05918.11 EMC83361.1 - 0.027 13.3 4.5 3.1 6.5 0.2 4.2 5 0 0 5 5 5 0 Apoptosis inhibitory protein 5 (API5) VHS PF00790.19 EMC83361.1 - 0.035 13.9 1.3 1.8 8.4 0.0 3.5 4 0 0 4 4 2 0 VHS domain MOR2-PAG1_N PF14222.6 EMC83361.1 - 0.053 12.5 0.6 3.7 6.4 0.0 3.5 3 1 1 4 4 4 0 Cell morphogenesis N-terminal RasGEF_N_2 PF14663.6 EMC83361.1 - 0.06 13.8 0.6 20 5.6 0.1 4.6 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain MMS22L_C PF14911.6 EMC83361.1 - 0.11 11.6 3.2 1.5 7.8 0.2 4.0 4 2 1 5 5 5 0 S-phase genomic integrity recombination mediator, C-terminal Dopey_N PF04118.14 EMC83361.1 - 0.21 10.7 5.9 2.4 7.2 0.0 4.3 4 1 1 5 5 5 0 Dopey, N-terminal V-ATPase_H_N PF03224.14 EMC83361.1 - 0.25 10.6 4.6 4.5 6.5 0.6 4.0 3 2 0 3 3 3 0 V-ATPase subunit H RNA_pol_3_Rpc31 PF11705.8 EMC83361.1 - 2.1 8.6 6.4 16 5.7 6.6 2.0 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 HhH-GPD PF00730.25 EMC83362.1 - 3.9e-06 27.3 0.0 5.1e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein WD40 PF00400.32 EMC83363.1 - 3.5e-09 37.2 10.4 0.19 12.6 0.2 7.0 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC83363.1 - 7.5e-08 32.6 0.4 0.033 14.5 0.1 4.7 5 1 0 5 5 4 2 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 EMC83363.1 - 2e-05 23.8 3.1 0.039 13.0 0.0 4.2 5 1 0 5 5 5 2 Coatomer WD associated region TPR_7 PF13176.6 EMC83363.1 - 0.0002 21.2 5.7 0.062 13.3 0.1 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC83363.1 - 0.0011 19.2 2.3 1.3 9.3 0.1 4.5 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 Prok-RING_4 PF14447.6 EMC83363.1 - 0.019 14.8 2.3 0.082 12.8 2.3 2.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Clathrin PF00637.20 EMC83363.1 - 0.046 13.6 1.6 4.9 7.0 0.0 3.6 2 2 2 4 4 4 0 Region in Clathrin and VPS TPR_2 PF07719.17 EMC83363.1 - 0.45 10.8 21.9 0.19 11.9 0.8 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 EMC83363.1 - 4.6 7.6 11.1 1.7 9.0 0.1 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 EMC83363.1 - 4.8 8.3 12.0 34 5.6 0.4 5.4 5 1 0 5 5 5 0 Tetratricopeptide repeat zf-RING_4 PF14570.6 EMC83363.1 - 5.3 6.9 9.9 9.8 6.1 2.5 2.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 EMC83363.1 - 5.4 7.0 17.1 0.067 13.1 1.6 3.2 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Tmemb_cc2 PF10267.9 EMC83364.1 - 1.1e-169 564.9 14.1 1.1e-169 564.9 14.1 1.5 2 0 0 2 2 2 1 Predicted transmembrane and coiled-coil 2 protein LMBR1 PF04791.16 EMC83364.1 - 0.00077 18.5 0.5 0.00077 18.5 0.5 2.1 2 0 0 2 2 2 1 LMBR1-like membrane protein CbiA PF01656.23 EMC83364.1 - 0.016 15.3 0.3 0.069 13.2 0.0 2.2 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Exonuc_VII_L PF02601.15 EMC83364.1 - 0.058 13.0 18.2 1.1 8.8 9.8 2.5 2 0 0 2 2 2 0 Exonuclease VII, large subunit UPF0565 PF10561.9 EMC83364.1 - 0.062 12.5 4.6 0.053 12.7 0.3 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0565 Vma12 PF11712.8 EMC83364.1 - 0.34 11.0 5.5 0.45 10.6 1.0 2.4 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DIRP PF06584.13 EMC83364.1 - 1.7 8.9 8.5 0.073 13.3 0.7 2.7 2 1 0 2 2 2 0 DIRP DUF3453 PF11935.8 EMC83364.1 - 2.4 7.7 9.5 0.067 12.8 1.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3453) Pentapeptide_4 PF13599.6 EMC83365.1 - 0.23 11.6 0.0 10 6.4 0.0 2.1 1 1 1 2 2 2 0 Pentapeptide repeats (9 copies) TRH PF05438.12 EMC83366.1 - 8.3e-91 303.6 10.6 2.2e-88 295.7 5.1 2.0 2 0 0 2 2 2 2 Thyrotropin-releasing hormone (TRH) Med2 PF11214.8 EMC83366.1 - 0.037 14.2 0.0 0.33 11.1 0.0 2.2 2 0 0 2 2 2 0 Mediator complex subunit 2 NPF PF16601.5 EMC83367.1 - 1e-45 156.5 22.0 1e-45 156.5 22.0 1.9 2 0 0 2 2 2 1 Rabosyn-5 repeating NPF sequence-motif Rbsn PF11464.8 EMC83367.1 - 4.5e-29 99.9 11.0 1.6e-15 56.5 4.0 2.9 2 0 0 2 2 2 2 Rabenosyn Rab binding domain FYVE PF01363.21 EMC83367.1 - 5.7e-18 64.8 6.1 1.3e-17 63.6 6.1 1.7 1 0 0 1 1 1 1 FYVE zinc finger RNA_POL_M_15KD PF02150.16 EMC83367.1 - 0.024 14.5 5.5 0.034 14.0 1.2 2.7 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit TerY_C PF15616.6 EMC83367.1 - 0.049 13.7 0.1 0.14 12.2 0.1 1.8 1 0 0 1 1 1 0 TerY-C metal binding domain NINJA_B PF16136.5 EMC83367.1 - 0.076 13.4 0.2 0.076 13.4 0.2 3.3 3 0 0 3 3 3 0 Putative nuclear localisation signal zinc_ribbon_9 PF14369.6 EMC83367.1 - 0.083 13.2 3.3 0.23 11.7 0.3 2.6 2 0 0 2 2 2 0 zinc-ribbon DZR PF12773.7 EMC83367.1 - 0.34 11.0 7.6 0.16 12.0 2.4 2.4 2 0 0 2 2 2 0 Double zinc ribbon IBR PF01485.21 EMC83367.1 - 0.61 10.3 7.1 0.15 12.3 2.4 2.3 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain zinc-ribbons_6 PF07191.12 EMC83367.1 - 5.1 7.1 9.3 0.77 9.8 2.7 2.5 2 0 0 2 2 2 0 zinc-ribbons HypA PF01155.19 EMC83367.1 - 7 6.7 10.0 0.3 11.1 0.4 3.3 3 1 1 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Hormone_recep PF00104.30 EMC83368.1 - 6.7e-46 156.5 0.8 1.2e-45 155.6 0.8 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 EMC83368.1 - 5.8e-32 110.0 16.3 1.2e-31 109.0 16.3 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) FAA_hydro_N_2 PF18288.1 EMC83368.1 - 0.07 13.6 0.4 0.58 10.6 0.1 2.7 2 2 0 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 DUF4573 PF15140.6 EMC83370.1 - 5.6e-10 39.3 0.0 2.5e-05 24.1 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4573) MSSP PF03940.13 EMC83370.1 - 6.8 6.4 81.5 1.8e+04 -43.1 81.5 4.3 1 1 0 1 1 1 0 Male specific sperm protein Dynamitin PF04912.14 EMC83371.1 - 2.2e-129 432.2 7.3 2.5e-129 432.0 7.3 1.0 1 0 0 1 1 1 1 Dynamitin DUF3763 PF12592.8 EMC83371.1 - 0.053 13.6 0.7 1.1 9.4 0.1 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3763) Vps8 PF12816.7 EMC83371.1 - 0.058 12.9 0.0 0.16 11.5 0.0 1.7 1 0 0 1 1 1 0 Golgi CORVET complex core vacuolar protein 8 TRPM_tetra PF16519.5 EMC83371.1 - 0.13 12.4 5.1 56 4.0 0.1 4.3 3 1 1 4 4 4 0 Tetramerisation domain of TRPM GreA_GreB_N PF03449.15 EMC83371.1 - 0.34 11.1 6.1 6.4 7.0 0.7 3.8 3 0 0 3 3 3 0 Transcription elongation factor, N-terminal Tropomyosin_1 PF12718.7 EMC83371.1 - 0.54 10.4 13.0 9.3 6.4 0.6 3.6 3 1 0 3 3 3 0 Tropomyosin like DUF2203 PF09969.9 EMC83371.1 - 2 9.2 9.1 5.8 7.7 0.2 3.6 2 1 2 4 4 4 0 Uncharacterized conserved protein (DUF2203) DUF3734 PF12536.8 EMC83371.1 - 2.5 8.5 7.4 27 5.2 0.4 3.4 3 0 0 3 3 3 0 Patatin phospholipase bZIP_2 PF07716.15 EMC83371.1 - 3 8.0 13.3 0.36 10.9 1.9 3.8 3 1 1 4 4 4 0 Basic region leucine zipper Osmo_CC PF08946.10 EMC83371.1 - 3.1 8.1 6.9 20 5.5 0.2 3.6 3 0 0 3 3 3 0 Osmosensory transporter coiled coil Baculo_PEP_C PF04513.12 EMC83371.1 - 4.7 7.3 15.7 3.3 7.7 1.0 3.2 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus GrpE PF01025.19 EMC83371.1 - 5.5 6.6 10.3 0.51 10.0 0.6 2.9 2 1 0 2 2 2 0 GrpE ZapB PF06005.12 EMC83371.1 - 5.9 7.4 18.1 1.2 9.7 4.2 4.5 3 1 0 3 3 3 0 Cell division protein ZapB FlaC_arch PF05377.11 EMC83371.1 - 9.5 6.7 11.0 19 5.8 0.2 4.4 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Pkinase PF00069.25 EMC83372.1 - 1.1e-44 152.8 0.0 1.4e-44 152.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC83372.1 - 2.1e-29 102.6 0.0 2.6e-29 102.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Seadorna_VP7 PF07387.11 EMC83372.1 - 0.083 11.9 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Flavodoxin_1 PF00258.25 EMC83373.1 - 3e-30 105.3 0.0 4.4e-30 104.8 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.20 EMC83373.1 - 2.5e-12 46.9 0.0 4.2e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_5 PF12724.7 EMC83373.1 - 1.9e-06 28.2 0.0 2.9e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin domain FAST_2 PF08368.12 EMC83374.1 - 2e-23 82.9 0.1 5.9e-23 81.5 0.1 1.9 1 0 0 1 1 1 1 FAST kinase-like protein, subdomain 2 FAST_1 PF06743.15 EMC83374.1 - 4.1e-20 71.5 1.9 4.1e-20 71.5 1.9 4.2 5 0 0 5 5 5 1 FAST kinase-like protein, subdomain 1 RAP PF08373.10 EMC83374.1 - 4.4e-13 49.1 0.0 9.1e-13 48.1 0.0 1.6 1 0 0 1 1 1 1 RAP domain DUF776 PF05604.11 EMC83375.1 - 4.1e-55 187.0 5.4 6.5e-55 186.3 5.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF776) SIP1 PF04938.12 EMC83375.1 - 0.023 14.4 0.1 0.034 13.8 0.1 1.3 1 0 0 1 1 1 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) DUF776 PF05604.11 EMC83376.1 - 3.3e-70 236.2 11.6 5.4e-70 235.4 11.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF776) MORN PF02493.20 EMC83377.1 - 1.2e-34 116.1 70.0 7.4e-07 28.7 3.2 8.7 9 0 0 9 9 9 8 MORN repeat CrgA PF06781.12 EMC83378.1 - 0.32 11.1 1.8 1.1 9.4 1.8 2.0 1 1 0 1 1 1 0 Cell division protein CrgA 7tm_1 PF00001.21 EMC83379.1 - 2.8e-07 30.1 10.3 3.5e-07 29.8 10.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 EMC83379.1 - 0.11 11.7 4.2 0.03 13.6 1.8 1.4 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srw DC_STAMP PF07782.13 EMC83380.1 - 3.3e-39 134.7 0.7 3.3e-39 134.7 0.7 1.8 2 1 0 2 2 2 1 DC-STAMP-like protein DUF1981 PF09324.10 EMC83380.1 - 0.091 12.6 0.9 0.2 11.6 0.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1981) EI24 PF07264.11 EMC83380.1 - 5.7 7.2 14.7 1.3 9.3 4.5 2.9 2 1 1 3 3 3 0 Etoposide-induced protein 2.4 (EI24) Transglut_N PF00868.20 EMC83381.1 - 5.4e-30 104.2 0.0 1.4e-29 102.8 0.0 1.8 1 0 0 1 1 1 1 Transglutaminase family Transglut_C PF00927.22 EMC83381.1 - 2.2e-28 98.5 0.1 2.5e-15 56.5 0.0 2.7 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_core PF01841.19 EMC83381.1 - 1.6e-17 64.0 0.2 4.4e-17 62.6 0.2 1.8 1 0 0 1 1 1 1 Transglutaminase-like superfamily GCIP PF13324.6 EMC83382.1 - 1.2e-81 274.2 1.4 1.4e-81 274.0 1.4 1.0 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting AAA_12 PF13087.6 EMC83383.1 - 2.4e-39 135.0 0.0 7.2e-39 133.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EMC83383.1 - 1.1e-29 104.0 7.3 5.8e-14 52.5 7.6 2.7 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EMC83383.1 - 1.2e-09 38.7 3.6 2.8e-08 34.2 3.6 2.6 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EMC83383.1 - 2.2e-08 34.1 1.3 0.00023 20.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.9 EMC83383.1 - 5.3e-05 22.6 0.5 0.002 17.4 0.0 3.2 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 EMC83383.1 - 0.0013 18.8 1.0 0.0032 17.5 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EMC83383.1 - 0.0061 16.8 2.1 0.29 11.4 0.0 3.2 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 EMC83383.1 - 0.01 15.3 0.0 0.028 13.9 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein DEAD PF00270.29 EMC83383.1 - 0.013 15.3 0.8 0.048 13.4 0.1 2.2 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_25 PF13481.6 EMC83383.1 - 0.059 12.9 1.8 0.17 11.4 0.1 2.5 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EMC83383.1 - 0.11 12.6 0.1 1.3 9.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ATP-synt_E_2 PF08112.11 EMC83383.1 - 0.28 11.5 2.3 0.53 10.6 0.7 2.3 2 0 0 2 2 2 0 ATP synthase epsilon subunit DUF3361 PF11841.8 EMC83384.1 - 3.9e-59 199.0 6.6 9e-59 197.8 6.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) ELMO_CED12 PF04727.13 EMC83384.1 - 3.3e-40 138.1 0.3 5.7e-40 137.3 0.3 1.4 1 0 0 1 1 1 1 ELMO/CED-12 family PH_12 PF16457.5 EMC83384.1 - 2.7e-38 131.5 0.1 8.4e-38 129.9 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain SIL1 PF16782.5 EMC83384.1 - 0.0044 16.3 2.6 0.012 14.8 2.5 1.7 1 1 0 1 1 1 1 Nucleotide exchange factor SIL1 TPT PF03151.16 EMC83385.1 - 1.9e-15 57.0 4.8 2.2e-15 56.8 4.8 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EMC83385.1 - 2.4e-05 24.5 26.5 3.8e-05 23.9 9.3 2.2 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 EMC83385.1 - 0.016 14.4 13.0 0.026 13.8 13.0 1.2 1 0 0 1 1 1 0 UAA transporter family DUF4418 PF14387.6 EMC83385.1 - 1.2 9.3 6.0 1.4 9.1 0.3 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4418) Cadherin PF00028.17 EMC83387.1 - 4e-84 277.2 11.5 4.8e-20 71.8 0.1 5.4 5 1 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 EMC83387.1 - 3.1e-48 163.8 0.1 5.7e-48 162.9 0.1 1.4 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_2 PF08266.12 EMC83387.1 - 1.8e-07 30.9 0.1 0.065 13.1 0.0 4.2 4 0 0 4 4 4 2 Cadherin-like Cadherin_3 PF16184.5 EMC83387.1 - 2.6e-05 24.2 8.0 1.1 9.2 0.0 5.2 5 0 0 5 5 5 2 Cadherin-like TAS2R PF05296.13 EMC83387.1 - 0.059 12.5 0.1 0.092 11.8 0.1 1.2 1 0 0 1 1 1 0 Taste receptor protein (TAS2R) Stevor PF17410.2 EMC83387.1 - 0.12 11.9 0.2 0.2 11.2 0.2 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Cadherin_pro PF08758.11 EMC83387.1 - 0.16 12.1 0.0 0.62 10.3 0.0 2.0 1 0 0 1 1 1 0 Cadherin prodomain like 7TM_GPCR_Srw PF10324.9 EMC83387.1 - 0.18 11.1 0.1 0.26 10.5 0.1 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw PepSY PF03413.19 EMC83387.1 - 0.27 11.8 1.9 1.4 9.6 0.0 3.1 3 0 0 3 3 3 0 Peptidase propeptide and YPEB domain Invasin_D3 PF09134.10 EMC83387.1 - 0.38 11.1 5.2 6.3 7.2 0.1 3.7 4 1 0 4 4 4 0 Invasin, domain 3 TNFR_c6 PF00020.18 EMC83389.1 - 1.6e-15 57.2 39.1 3.3e-06 27.4 1.5 4.5 4 0 0 4 4 4 3 TNFR/NGFR cysteine-rich region RANK_CRD_2 PF18278.1 EMC83389.1 - 0.0089 16.2 7.4 0.0089 16.2 7.4 2.7 2 1 0 2 2 2 1 Receptor activator of the NF-KB cysteine-rich repeat domain 2 HGTP_anticodon PF03129.20 EMC83390.1 - 0.0004 20.5 0.0 0.00087 19.4 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain Macoilin PF09726.9 EMC83390.1 - 0.025 13.2 0.1 0.041 12.5 0.1 1.2 1 0 0 1 1 1 0 Macoilin family zf-C3HC4_4 PF15227.6 EMC83391.1 - 0.00047 20.3 3.4 0.0015 18.6 3.4 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EMC83391.1 - 0.00056 19.8 5.1 0.0012 18.8 5.1 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EMC83391.1 - 0.0011 18.9 4.9 0.0048 16.9 4.9 2.2 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EMC83391.1 - 0.0022 17.8 5.8 0.0052 16.6 5.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC83391.1 - 0.0097 15.7 7.8 0.025 14.4 7.8 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EMC83391.1 - 0.012 15.9 7.6 0.012 15.9 7.6 2.4 3 0 0 3 3 3 0 Ring finger domain zf-RING_4 PF14570.6 EMC83391.1 - 6.9 6.6 13.9 0.061 13.1 5.7 1.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain PCIF1_WW PF12237.8 EMC83392.1 - 7.9e-70 233.9 0.2 1.2e-69 233.3 0.2 1.3 1 0 0 1 1 1 1 Phosphorylated CTD interacting factor 1 WW domain WW PF00397.26 EMC83392.1 - 1.4e-10 41.1 0.7 2.7e-10 40.2 0.7 1.5 1 0 0 1 1 1 1 WW domain IMUP PF15761.5 EMC83392.1 - 0.37 11.5 6.4 1.1 10.0 6.4 1.7 1 0 0 1 1 1 0 Immortalisation up-regulated protein LBP_BPI_CETP_C PF02886.17 EMC83393.1 - 2.2e-50 171.3 0.0 3.5e-50 170.7 0.0 1.3 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 EMC83393.1 - 2e-27 95.8 0.1 1.1e-26 93.4 0.1 2.0 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain TGBp3 PF02495.17 EMC83393.1 - 0.084 12.5 0.1 14 5.4 0.0 2.5 2 0 0 2 2 2 0 Triple gene block 3 Peptidase_S10 PF00450.22 EMC83394.1 - 2.5e-106 356.6 0.2 2.8e-106 356.4 0.2 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Neuralized PF07177.12 EMC83395.1 - 1.6e-13 50.9 0.0 2.7e-13 50.2 0.0 1.4 1 1 0 1 1 1 1 Neuralized SOCS_box PF07525.16 EMC83395.1 - 7.9e-07 29.3 2.1 7.9e-07 29.3 2.1 2.2 2 0 0 2 2 2 1 SOCS box SWIM PF04434.17 EMC83396.1 - 0.0031 17.1 0.3 0.0031 17.1 0.3 2.8 3 0 0 3 3 3 1 SWIM zinc finger 4HBT_3 PF13622.6 EMC83397.1 - 2.4e-50 172.1 0.0 2.7e-50 172.0 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 EMC83397.1 - 1.3e-30 105.9 0.0 4.9e-27 94.4 0.0 2.2 2 0 0 2 2 2 2 Acyl-CoA thioesterase EF-hand_1 PF00036.32 EMC83398.1 - 8.2e-30 100.1 24.0 2.5e-08 32.9 0.7 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EMC83398.1 - 9.7e-30 102.8 10.3 1.9e-16 60.2 5.5 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EMC83398.1 - 6.6e-24 81.8 13.4 8.8e-07 28.4 0.1 4.5 4 1 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EMC83398.1 - 3.7e-23 81.1 18.2 3e-13 49.4 0.5 3.5 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 EMC83398.1 - 4e-20 70.3 20.6 6.6e-06 25.4 0.3 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 EMC83398.1 - 1.8e-16 60.2 1.0 1.8e-07 31.3 0.2 2.1 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EMC83398.1 - 1.9e-06 28.2 0.7 0.0013 19.0 0.5 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EMC83398.1 - 8.2e-06 25.7 9.9 0.034 14.1 0.2 3.4 1 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_11 PF08976.11 EMC83398.1 - 0.0023 18.8 0.1 2.8 8.8 0.1 2.1 1 1 1 2 2 2 2 EF-hand domain p25-alpha PF05517.12 EMC83398.1 - 0.0037 17.4 0.9 0.087 13.0 0.1 2.2 1 1 0 2 2 2 1 p25-alpha TerB PF05099.13 EMC83398.1 - 0.0092 15.9 2.8 0.11 12.4 0.6 2.2 1 1 1 2 2 2 1 Tellurite resistance protein TerB EF-hand_14 PF17959.1 EMC83398.1 - 0.017 15.5 0.4 1.2 9.5 0.2 2.5 2 1 0 2 2 2 0 EF-hand domain HopW1-1 PF15457.6 EMC83398.1 - 0.025 13.9 0.1 0.79 8.9 0.0 2.0 1 1 1 2 2 2 0 Type III T3SS secreted effector HopW1-1/HopPmaA DUF1456 PF07308.13 EMC83398.1 - 0.036 14.4 3.2 2 8.8 0.2 2.8 3 1 0 3 3 2 0 Protein of unknown function (DUF1456) DUF1296 PF06972.11 EMC83398.1 - 0.059 13.5 0.6 6.4 7.0 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1296) DUF5580 PF17743.1 EMC83398.1 - 0.066 11.8 0.0 0.08 11.5 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) FlgD PF03963.14 EMC83398.1 - 0.066 13.5 0.2 3.2 8.1 0.0 2.4 2 1 0 2 2 2 0 Flagellar hook capping protein - N-terminal region Syntaxin PF00804.25 EMC83398.1 - 0.07 12.8 2.0 2 8.0 0.2 2.2 2 0 0 2 2 2 0 Syntaxin Phage_TAC_12 PF12363.8 EMC83398.1 - 0.072 13.5 0.8 9.1 6.7 0.1 2.2 2 0 0 2 2 2 0 Phage tail assembly chaperone protein, TAC VbhA PF18495.1 EMC83398.1 - 0.4 10.6 3.5 17 5.4 0.1 4.0 4 1 0 4 4 4 0 Antitoxin VbhA UQ_con PF00179.26 EMC83399.1 - 5.6e-34 116.8 0.0 5.9e-34 116.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EMC83399.1 - 0.0089 15.9 0.0 0.017 15.0 0.0 1.5 1 1 0 1 1 1 1 UEV domain RWD PF05773.22 EMC83399.1 - 0.0095 16.2 0.0 0.01 16.1 0.0 1.1 1 0 0 1 1 1 1 RWD domain DNTTIP1_dimer PF18192.1 EMC83400.1 - 8.1e-27 93.4 0.1 1.2e-26 92.9 0.1 1.2 1 0 0 1 1 1 1 DNTTIP1 dimerisation domain LolA PF03548.15 EMC83400.1 - 0.094 12.4 0.0 0.79 9.4 0.0 2.2 2 0 0 2 2 2 0 Outer membrane lipoprotein carrier protein LolA DUF4385 PF14328.6 EMC83400.1 - 0.13 12.4 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4385) Kunitz_BPTI PF00014.23 EMC83401.1 - 2.1e-16 59.9 15.0 2.1e-16 59.9 15.0 1.6 2 0 0 2 2 2 1 Kunitz/Bovine pancreatic trypsin inhibitor domain WAP PF00095.21 EMC83401.1 - 3.4e-05 24.1 12.4 3.4e-05 24.1 12.4 2.9 2 1 0 2 2 2 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' WAP PF00095.21 EMC83402.1 - 3.2e-47 158.6 104.5 1.5e-11 44.5 15.9 5.1 5 0 0 5 5 5 5 WAP-type (Whey Acidic Protein) 'four-disulfide core' Pap_E4 PF02711.14 EMC83402.1 - 3.2 8.8 4.6 2.1 9.4 2.0 2.1 2 0 0 2 2 2 0 E4 protein WAP PF00095.21 EMC83403.1 - 2.2e-21 76.0 41.2 6.2e-12 45.7 16.9 2.0 2 0 0 2 2 2 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' Kunitz_BPTI PF00014.23 EMC83404.1 - 6.9e-21 74.2 3.6 6.9e-21 74.2 3.6 2.7 3 0 0 3 3 3 1 Kunitz/Bovine pancreatic trypsin inhibitor domain WAP PF00095.21 EMC83404.1 - 1.8e-19 69.8 36.3 5.8e-11 42.6 13.5 3.3 3 1 0 3 3 3 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' CTNNBL PF08216.11 EMC83405.1 - 1.5e-39 134.3 1.4 1.5e-39 134.3 1.4 2.0 2 0 0 2 2 2 1 Catenin-beta-like, Arm-motif containing nuclear Arm PF00514.23 EMC83405.1 - 0.0043 17.1 4.9 5.3 7.2 0.1 3.8 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 EMC83405.1 - 0.04 13.9 0.1 0.17 11.9 0.1 2.1 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain RecO_C PF02565.15 EMC83405.1 - 0.044 13.6 1.0 40 4.0 0.1 3.5 2 1 1 3 3 3 0 Recombination protein O C terminal V-set PF07686.17 EMC83406.1 - 8.8e-10 38.7 0.1 9.8e-09 35.4 0.1 2.0 1 1 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.16 EMC83406.1 - 1.3e-09 37.9 0.2 1.7e-07 31.2 0.2 2.2 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC83406.1 - 9.4e-08 32.6 0.2 5e-07 30.2 0.2 1.9 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC83406.1 - 6.7e-06 26.2 0.1 3.2e-05 24.0 0.1 1.9 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC83406.1 - 0.0007 19.9 0.1 0.58 10.5 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Izumo-Ig PF16706.5 EMC83406.1 - 0.076 13.1 0.0 0.23 11.6 0.0 1.8 1 1 1 2 2 2 0 Izumo-like Immunoglobulin domain HEAT_2 PF13646.6 EMC83407.1 - 5.6e-07 29.9 3.4 0.23 11.9 0.2 4.6 3 1 1 4 4 4 2 HEAT repeats HEAT PF02985.22 EMC83407.1 - 2.5e-05 24.2 16.2 2.3 8.7 0.0 8.2 8 0 0 8 8 8 2 HEAT repeat VHS PF00790.19 EMC83407.1 - 5.7e-05 23.0 3.7 0.45 10.4 0.0 4.4 5 0 0 5 5 5 2 VHS domain CTD_bind PF04818.13 EMC83407.1 - 0.0031 18.3 0.1 0.97 10.3 0.1 3.3 2 0 0 2 2 2 1 RNA polymerase II-binding domain. Cnd1 PF12717.7 EMC83407.1 - 0.0048 17.0 0.4 0.038 14.0 0.1 2.6 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Dopey_N PF04118.14 EMC83407.1 - 0.029 13.5 2.3 0.55 9.3 0.1 3.6 3 2 1 4 4 4 0 Dopey, N-terminal DUF5331 PF17265.2 EMC83407.1 - 0.062 13.0 0.0 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5331) Arm PF00514.23 EMC83407.1 - 0.067 13.3 0.2 24 5.2 0.0 3.8 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Vac14_Fab1_bd PF12755.7 EMC83407.1 - 0.11 13.1 0.1 12 6.6 0.0 3.6 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region DUF4042 PF13251.6 EMC83407.1 - 0.14 11.9 1.1 12 5.5 0.2 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4042) Sec7_N PF12783.7 EMC83407.1 - 8.6 6.2 7.0 7.4 6.5 0.3 3.6 4 0 0 4 4 4 0 Guanine nucleotide exchange factor in Golgi transport N-terminal CREPT PF16566.5 EMC83408.1 - 6.2e-63 211.4 5.6 6.2e-63 211.4 5.6 2.0 2 0 0 2 2 2 1 Cell-cycle alteration and expression-elevated protein in tumour CTD_bind PF04818.13 EMC83408.1 - 1e-22 80.7 1.3 7.4e-22 78.0 0.0 2.9 4 0 0 4 4 4 1 RNA polymerase II-binding domain. Rep_4 PF05797.11 EMC83408.1 - 0.066 12.3 3.0 0.28 10.2 1.9 2.1 2 0 0 2 2 2 0 Yeast trans-acting factor (REP1/REP2) PDCD7 PF16021.5 EMC83408.1 - 0.1 11.7 11.8 0.41 9.7 0.9 2.6 3 0 0 3 3 3 0 Programmed cell death protein 7 DUF2408 PF10303.9 EMC83408.1 - 0.85 10.2 8.9 2.1 8.9 1.6 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2408) Swi5 PF07061.11 EMC83408.1 - 1 9.5 11.4 2.8 8.1 2.1 3.3 3 1 0 3 3 3 0 Swi5 Dzip-like_N PF13815.6 EMC83408.1 - 3.2 7.7 8.3 0.64 10.0 2.6 2.4 2 0 0 2 2 2 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal Snapin_Pallidin PF14712.6 EMC83408.1 - 7.4 7.1 12.8 10 6.6 1.7 3.3 2 1 0 3 3 3 0 Snapin/Pallidin Takusan PF04822.13 EMC83408.1 - 7.5 6.5 11.6 2.5 8.0 2.0 3.0 2 1 0 2 2 2 0 Takusan PIN_8 PF18476.1 EMC83408.1 - 9.7 6.0 9.8 3.4 7.4 2.0 2.4 1 1 1 2 2 2 0 PIN like domain Transglut_C PF00927.22 EMC83409.1 - 5.6e-36 122.9 0.1 4.7e-22 78.1 0.0 3.5 2 1 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_N PF00868.20 EMC83409.1 - 2.1e-26 92.6 0.0 3.6e-26 91.8 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase family Transglut_core PF01841.19 EMC83409.1 - 1e-17 64.6 0.6 2.1e-17 63.6 0.6 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily LBP_BPI_CETP_C PF02886.17 EMC83412.1 - 7.2e-66 222.0 0.0 1.3e-65 221.2 0.0 1.4 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 EMC83412.1 - 1.8e-39 135.0 0.1 9.3e-39 132.7 0.0 2.2 3 0 0 3 3 3 1 LBP / BPI / CETP family, N-terminal domain Radical_SAM PF04055.21 EMC83413.1 - 5.3e-31 108.3 0.0 9.5e-31 107.4 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily UPF0004 PF00919.20 EMC83413.1 - 2.3e-30 104.5 0.0 5e-30 103.5 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 TRAM PF01938.20 EMC83413.1 - 2.3e-13 49.9 0.0 4.2e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 TRAM domain LBP_BPI_CETP PF01273.25 EMC83414.1 - 3.9e-34 117.6 4.7 1.9e-22 79.6 0.3 2.6 2 0 0 2 2 2 2 LBP / BPI / CETP family, N-terminal domain LBP_BPI_CETP_C PF02886.17 EMC83414.1 - 3.4e-22 79.1 3.4 5.6e-22 78.4 0.8 2.2 2 0 0 2 2 2 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP_C PF02886.17 EMC83416.1 - 7.1e-11 42.0 3.0 7.1e-11 42.0 3.0 2.4 2 1 1 3 3 3 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 EMC83416.1 - 8.5e-07 28.7 1.7 1.3e-05 24.9 0.1 3.1 2 2 1 3 3 3 1 LBP / BPI / CETP family, N-terminal domain LBP_BPI_CETP PF01273.25 EMC83417.1 - 6.7e-19 68.1 8.3 6.7e-19 68.1 8.3 2.3 2 1 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain LBP_BPI_CETP_C PF02886.17 EMC83417.1 - 3.5e-11 43.0 0.4 3.5e-11 43.0 0.4 2.2 2 1 1 3 3 3 1 LBP / BPI / CETP family, C-terminal domain EB1 PF03271.17 EMC83418.1 - 3.2e-18 65.7 0.8 1.9e-17 63.2 0.7 2.2 2 0 0 2 2 2 1 EB1-like C-terminal motif CH PF00307.31 EMC83418.1 - 6.5e-14 52.0 0.8 9.7e-14 51.5 0.2 1.6 2 0 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EMC83418.1 - 0.011 15.5 0.1 0.036 13.9 0.0 1.8 2 1 1 3 3 3 0 CAMSAP CH domain SUIM_assoc PF16619.5 EMC83418.1 - 0.12 12.4 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 CCDC106 PF15794.5 EMC83418.1 - 0.22 11.2 0.1 0.34 10.6 0.1 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 PWWP PF00855.17 EMC83419.1 - 6.1e-12 45.8 0.1 1.3e-11 44.7 0.1 1.5 1 0 0 1 1 1 1 PWWP domain DNA_methylase PF00145.17 EMC83419.1 - 4.8e-11 42.6 0.0 4.3e-09 36.2 0.0 2.2 2 0 0 2 2 2 2 C-5 cytosine-specific DNA methylase ADD_DNMT3 PF17980.1 EMC83419.1 - 1.6e-05 24.8 0.2 0.014 15.4 0.0 2.7 2 0 0 2 2 2 2 Cysteine rich ADD domain in DNMT3 RBB1NT PF08169.11 EMC83419.1 - 0.13 12.4 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 RBB1NT (NUC162) domain Phytochelatin_C PF09328.10 EMC83419.1 - 2.9 7.2 4.2 4.8 6.4 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1984) COMM_domain PF07258.14 EMC83420.1 - 4.3e-17 62.0 0.1 8.9e-17 61.0 0.1 1.6 1 0 0 1 1 1 1 COMM domain ASXH PF13919.6 EMC83422.1 - 1.7e-36 125.3 0.1 4.3e-36 124.0 0.1 1.7 1 0 0 1 1 1 1 Asx homology domain PHD_3 PF13922.6 EMC83422.1 - 2.2e-20 72.8 9.5 9.6e-20 70.7 9.5 2.2 1 0 0 1 1 1 1 PHD domain of transcriptional enhancer, Asx HARE-HTH PF05066.13 EMC83422.1 - 1.4e-14 54.2 0.0 2.8e-14 53.2 0.0 1.6 1 0 0 1 1 1 1 HB1, ASXL, restriction endonuclease HTH domain TT_ORF2a PF08197.11 EMC83422.1 - 2.8 8.0 12.0 2 8.5 3.5 3.1 3 0 0 3 3 3 0 pORF2a truncated protein PHD PF00628.29 EMC83422.1 - 5.5 7.0 9.1 14 5.7 9.1 1.7 1 0 0 1 1 1 0 PHD-finger Kinesin PF00225.23 EMC83423.1 - 1.9e-122 408.3 1.4 1.9e-122 408.3 1.4 2.2 2 1 1 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EMC83423.1 - 1.1e-28 100.1 0.1 1.1e-28 100.1 0.1 1.9 2 0 0 2 2 2 1 Microtubule binding Kinesin_assoc PF16183.5 EMC83423.1 - 0.022 14.9 0.2 0.022 14.9 0.2 2.8 2 1 0 3 3 3 0 Kinesin-associated AAA_16 PF13191.6 EMC83423.1 - 0.098 13.0 0.0 0.098 13.0 0.0 2.4 3 0 0 3 3 3 0 AAA ATPase domain DUF948 PF06103.11 EMC83423.1 - 7.7 6.9 11.0 0.66 10.3 3.7 2.9 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) zf-C2H2_4 PF13894.6 EMC83424.1 - 2.9e-20 71.2 54.7 0.00064 20.3 1.4 7.5 7 0 0 7 7 7 6 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC83424.1 - 3.8e-19 68.2 46.7 5.9e-05 23.3 4.7 7.5 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.26 EMC83424.1 - 3.2e-17 61.9 59.1 7.3e-05 23.0 1.8 7.3 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EMC83424.1 - 6.1e-07 29.3 43.0 0.00046 20.1 0.8 7.2 7 0 0 7 7 7 3 C2H2-type zinc finger zf-Di19 PF05605.12 EMC83424.1 - 0.0011 19.2 30.2 0.025 14.9 6.5 4.4 1 1 4 5 5 5 4 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.5 EMC83424.1 - 0.0063 16.2 2.0 0.13 12.0 0.3 5.8 6 0 0 6 6 6 2 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 EMC83424.1 - 0.0077 16.5 29.4 0.42 11.0 2.9 6.2 5 1 1 6 6 6 2 Zinc-finger double-stranded RNA-binding Acyltransf_C PF16076.5 EMC83424.1 - 0.015 15.4 0.7 7.6 6.7 0.0 2.6 2 0 0 2 2 2 0 Acyltransferase C-terminus zf-met2 PF12907.7 EMC83424.1 - 0.086 13.0 0.4 0.086 13.0 0.4 3.2 3 1 1 4 4 4 0 Zinc-binding Equine_IAV_S2 PF06502.11 EMC83424.1 - 0.16 12.1 0.3 0.47 10.6 0.3 1.8 1 0 0 1 1 1 0 Equine infectious anaemia virus S2 protein HNH_5 PF14279.6 EMC83424.1 - 0.2 11.5 12.4 2.5 8.0 0.4 4.3 3 1 0 3 3 3 0 HNH endonuclease zf-C2H2_2 PF12756.7 EMC83424.1 - 0.28 11.5 35.7 1 9.8 1.2 5.9 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 EMC83424.1 - 0.3 11.6 21.9 1 9.9 0.2 5.0 5 0 0 5 5 4 0 Zinc-finger of C2H2 type TF_Zn_Ribbon PF08271.12 EMC83424.1 - 1.3 8.6 4.9 3.9 7.1 0.4 2.9 2 1 0 2 2 2 0 TFIIB zinc-binding zinc_ribbon_15 PF17032.5 EMC83424.1 - 1.3 9.8 15.0 5.4 7.8 4.2 3.6 3 1 0 3 3 3 0 zinc-ribbon family FYDLN_acid PF09538.10 EMC83424.1 - 3.1 8.5 11.8 13 6.5 0.0 4.3 2 2 2 4 4 4 0 Protein of unknown function (FYDLN_acid) zf-C2H2_9 PF16293.5 EMC83424.1 - 5.4 6.9 7.9 1.1e+02 2.7 0.0 4.9 2 2 4 6 6 6 0 C2H2 type zinc-finger (1 copy) zf-LITAF-like PF10601.9 EMC83424.1 - 8.6 6.7 13.7 0.21 11.9 2.0 3.7 3 1 0 3 3 3 0 LITAF-like zinc ribbon domain EMP70 PF02990.16 EMC83425.1 - 2.5e-209 696.3 13.9 3.4e-209 695.8 13.9 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 DUF4229 PF14012.6 EMC83425.1 - 2.2 8.4 0.0 2.2 8.4 0.0 4.4 5 0 0 5 5 5 0 Protein of unknown function (DUF4229) Pkinase_Tyr PF07714.17 EMC83426.1 - 1.8e-95 319.1 0.0 2.3e-95 318.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC83426.1 - 2.3e-47 161.6 0.0 2.9e-47 161.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 EMC83426.1 - 6.3e-24 83.9 0.0 1.3e-23 82.9 0.0 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 EMC83426.1 - 2.3e-15 55.9 0.0 5.2e-15 54.8 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC83426.1 - 3.8e-12 45.9 0.0 8.9e-12 44.7 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC83426.1 - 2.6e-08 33.4 0.0 5.5e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 EMC83426.1 - 0.0039 17.4 0.0 0.0086 16.3 0.0 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain Haspin_kinase PF12330.8 EMC83426.1 - 0.012 14.5 0.1 0.031 13.2 0.1 1.6 1 1 0 1 1 1 0 Haspin like kinase domain CCM2_C PF16545.5 EMC83427.1 - 5.9e-50 167.9 0.1 9e-50 167.4 0.1 1.3 1 0 0 1 1 1 1 Cerebral cavernous malformation protein, harmonin-homology DUF1722 PF08349.11 EMC83427.1 - 0.13 12.6 0.0 0.26 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1722) FlxA PF14282.6 EMC83427.1 - 0.18 11.8 0.3 0.18 11.8 0.3 1.7 2 0 0 2 2 2 0 FlxA-like protein XK-related PF09815.9 EMC83428.1 - 1.8e-102 342.9 24.3 2e-102 342.7 24.3 1.0 1 0 0 1 1 1 1 XK-related protein ECF_trnsprt PF12822.7 EMC83428.1 - 0.19 11.8 12.4 0.43 10.7 12.4 1.6 1 1 0 1 1 1 0 ECF transporter, substrate-specific component Prefoldin_2 PF01920.20 EMC83429.1 - 3.3e-07 30.2 0.1 4.2e-07 29.9 0.1 1.2 1 0 0 1 1 1 1 Prefoldin subunit MICSWaP PF17018.5 EMC83429.1 - 0.035 13.7 0.4 0.037 13.6 0.4 1.1 1 0 0 1 1 1 0 Spore wall protein TPX2 PF06886.11 EMC83429.1 - 0.11 12.7 2.9 0.18 12.0 2.9 1.3 1 0 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) DSPc PF00782.20 EMC83430.1 - 3.9e-32 110.8 0.0 5.2e-32 110.4 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EMC83430.1 - 1.5e-06 28.5 0.0 2.2e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 EMC83430.1 - 1.9e-06 27.6 0.0 2.5e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase IRF-3 PF10401.9 EMC83432.1 - 1.7e-52 177.8 0.0 2.3e-52 177.4 0.0 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IRF PF00605.17 EMC83432.1 - 2.5e-43 146.6 0.9 4.1e-43 146.0 0.9 1.3 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor Pkinase PF00069.25 EMC83433.1 - 4.7e-41 140.9 0.0 2.5e-39 135.3 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC83433.1 - 1.9e-22 79.8 0.0 2.6e-22 79.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC83433.1 - 0.00067 18.5 0.0 0.00092 18.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EMC83433.1 - 0.00068 19.1 0.1 0.001 18.5 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EMC83433.1 - 0.0066 15.8 0.0 0.0095 15.3 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EMC83433.1 - 0.021 14.7 0.1 0.045 13.7 0.0 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family TPX2_importin PF12214.8 EMC83434.1 - 3e-43 147.9 72.9 3.6e-37 128.1 12.8 7.8 5 3 2 7 7 7 4 Cell cycle regulated microtubule associated protein Aurora-A_bind PF09041.10 EMC83434.1 - 5.2e-23 80.9 0.2 2e-22 79.0 0.2 2.1 1 0 0 1 1 1 1 Aurora-A binding TPX2 PF06886.11 EMC83434.1 - 3.8e-15 55.8 17.8 3.8e-15 55.8 17.8 7.2 7 0 0 7 7 7 1 Targeting protein for Xklp2 (TPX2) Bcl-2 PF00452.19 EMC83435.1 - 1.2e-31 109.3 0.0 2.1e-31 108.5 0.0 1.4 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family BH4 PF02180.17 EMC83435.1 - 3.9e-14 52.1 0.3 6.3e-14 51.4 0.3 1.4 1 0 0 1 1 1 1 Bcl-2 homology region 4 Bcl-2_3 PF15286.6 EMC83435.1 - 0.02 15.6 0.0 0.029 15.0 0.0 1.3 1 0 0 1 1 1 0 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like LBP_BPI_CETP_C PF02886.17 EMC83436.1 - 1.3e-27 96.8 0.0 1.6e-27 96.5 0.0 1.1 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain Peptidase_A22B PF04258.13 EMC83437.1 - 2.1e-103 345.8 9.3 2.4e-103 345.5 9.3 1.0 1 0 0 1 1 1 1 Signal peptide peptidase SPP PF06550.11 EMC83437.1 - 2.2e-05 24.1 6.7 4.1e-05 23.2 6.7 1.4 1 0 0 1 1 1 1 Signal-peptide peptidase, presenilin aspartyl protease Presenilin PF01080.17 EMC83437.1 - 0.0012 17.7 5.2 0.0012 17.7 5.2 1.7 1 1 0 1 1 1 1 Presenilin DUF4345 PF14248.6 EMC83437.1 - 0.13 12.2 0.0 0.13 12.2 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4345) Ras PF00071.22 EMC83438.1 - 1.6e-29 102.6 0.0 5.4e-29 100.9 0.0 1.7 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EMC83438.1 - 1.5e-06 28.4 0.0 0.013 15.7 0.0 2.6 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EMC83438.1 - 3.4e-05 23.8 0.0 0.15 11.9 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 EMC83438.1 - 5.1e-05 22.9 0.0 0.33 10.4 0.0 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B AAA_16 PF13191.6 EMC83438.1 - 0.0012 19.3 1.4 0.035 14.5 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 EMC83438.1 - 0.003 17.6 0.0 0.018 15.1 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA PF00004.29 EMC83438.1 - 0.0031 17.9 0.1 0.05 14.0 0.1 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EMC83438.1 - 0.015 15.3 0.0 0.041 13.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EMC83438.1 - 0.015 15.6 0.5 0.89 9.8 0.0 2.8 2 1 1 3 3 3 0 AAA domain RuvB_N PF05496.12 EMC83438.1 - 0.015 15.0 0.0 0.024 14.4 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 EMC83438.1 - 0.028 14.1 0.0 0.058 13.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EMC83438.1 - 0.033 14.7 0.0 0.079 13.5 0.0 1.6 2 0 0 2 2 2 0 ABC transporter DUF2369 PF10179.9 EMC83438.1 - 0.077 13.4 0.0 0.15 12.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2369) NACHT PF05729.12 EMC83438.1 - 0.078 12.9 0.0 0.32 10.9 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_18 PF13238.6 EMC83438.1 - 0.13 12.8 2.5 0.35 11.4 0.1 2.4 2 2 0 2 2 2 0 AAA domain DUF4618 PF15397.6 EMC83439.1 - 1.5e-58 198.3 24.7 1.7e-56 191.5 24.7 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4618) Spc7 PF08317.11 EMC83439.1 - 0.00019 20.4 10.1 0.00019 20.4 10.1 2.0 1 1 1 2 2 2 1 Spc7 kinetochore protein ATG16 PF08614.11 EMC83439.1 - 0.0034 17.6 7.0 0.0034 17.6 7.0 2.2 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) Syntaxin-6_N PF09177.11 EMC83439.1 - 0.013 16.0 12.5 0.029 14.9 7.8 2.6 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Prefoldin_2 PF01920.20 EMC83439.1 - 0.016 15.1 6.6 0.016 15.1 6.6 3.3 2 1 0 3 3 3 0 Prefoldin subunit DUF3858 PF12970.7 EMC83439.1 - 0.026 14.5 0.8 7 6.7 0.2 2.6 2 1 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3858) Peptidase_C97 PF05903.14 EMC83439.1 - 0.069 13.0 0.2 0.11 12.3 0.2 1.4 1 0 0 1 1 1 0 PPPDE putative peptidase domain PI3K_P85_iSH2 PF16454.5 EMC83439.1 - 0.083 12.5 20.6 0.26 10.9 3.0 2.2 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF4298 PF14131.6 EMC83439.1 - 0.11 12.4 8.6 0.053 13.5 3.4 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4298) Phage_HK97_TLTM PF06120.11 EMC83439.1 - 0.19 10.9 14.4 0.34 10.1 14.3 1.4 1 1 0 1 1 1 0 Tail length tape measure protein DDE_Tnp_IS66 PF03050.14 EMC83439.1 - 0.26 10.7 5.8 0.11 11.9 0.9 2.1 2 0 0 2 2 2 0 Transposase IS66 family Lebercilin PF15619.6 EMC83439.1 - 0.32 10.6 24.4 0.11 12.2 15.2 2.2 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF1319 PF07028.11 EMC83439.1 - 0.43 10.8 10.2 2.5 8.4 0.2 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF1319) CEP209_CC5 PF16574.5 EMC83439.1 - 0.9 9.7 21.2 1 9.6 11.6 2.3 1 1 1 2 2 2 0 Coiled-coil region of centrosome protein CE290 Vfa1 PF08432.10 EMC83439.1 - 1 9.7 9.3 1.4 9.2 9.3 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF1664 PF07889.12 EMC83439.1 - 1 9.4 15.5 0.18 11.8 6.1 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DUF2703 PF10865.8 EMC83439.1 - 1.5 9.1 9.1 0.16 12.1 1.4 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF2703) Swi5 PF07061.11 EMC83439.1 - 1.5 9.0 15.8 0.18 11.9 2.2 3.4 3 0 0 3 3 3 0 Swi5 DUF724 PF05266.14 EMC83439.1 - 1.9 8.3 18.1 3 7.6 3.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Med9 PF07544.13 EMC83439.1 - 2.3 8.4 20.4 1.3 9.1 0.3 3.3 2 2 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 DUF4407 PF14362.6 EMC83439.1 - 2.8 7.2 16.9 24 4.1 11.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Laminin_II PF06009.12 EMC83439.1 - 3 7.9 18.4 0.85 9.6 2.3 2.5 2 1 0 2 2 2 0 Laminin Domain II TraI_2_C PF07515.11 EMC83439.1 - 3 7.8 7.4 1.9 8.4 2.0 2.6 1 1 2 3 3 3 0 Putative conjugal transfer nickase/helicase TraI C-term Flg_hook PF02120.16 EMC83439.1 - 3.2 7.7 12.0 0.43 10.5 4.2 2.9 3 1 0 3 3 3 0 Flagellar hook-length control protein FliK Rootletin PF15035.6 EMC83439.1 - 4.2 7.4 26.3 17 5.3 25.4 2.0 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion MAP7 PF05672.11 EMC83439.1 - 5 6.8 17.4 1.8 8.2 4.2 2.1 2 0 0 2 2 2 0 MAP7 (E-MAP-115) family NPV_P10 PF05531.12 EMC83439.1 - 5.4 7.5 10.8 0.45 11.0 4.0 2.5 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Atg14 PF10186.9 EMC83439.1 - 6.7 5.7 18.1 5 6.1 10.0 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_13 PF13166.6 EMC83439.1 - 7.3 5.1 17.7 2.7 6.5 5.3 2.0 1 1 0 2 2 2 0 AAA domain Fib_alpha PF08702.10 EMC83439.1 - 9.1 6.5 20.5 4.6 7.4 9.6 2.3 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family RabGAP-TBC PF00566.18 EMC83440.1 - 2.4e-27 96.0 0.0 3.5e-27 95.5 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Mis14 PF08641.12 EMC83440.1 - 0.074 13.4 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 Kinetochore protein Mis14 like Pkinase PF00069.25 EMC83441.1 - 3e-72 243.2 0.3 3.5e-72 242.9 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC83441.1 - 1.6e-20 73.5 0.0 2.1e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EMC83441.1 - 4.8e-08 33.2 0.0 6.4e-06 26.3 0.1 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EMC83441.1 - 0.00036 19.9 0.1 0.00059 19.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMC83441.1 - 0.0053 15.6 0.1 0.016 14.0 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EMC83441.1 - 0.009 15.4 0.1 0.047 13.0 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Choline_kinase PF01633.20 EMC83441.1 - 0.02 14.5 0.2 0.02 14.5 0.2 1.6 2 0 0 2 2 2 0 Choline/ethanolamine kinase ABC1 PF03109.16 EMC83441.1 - 0.068 13.3 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 ABC1 family FTA2 PF13095.6 EMC83441.1 - 0.072 12.7 0.2 1.4 8.5 0.0 2.7 2 1 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 zf-C2H2 PF00096.26 EMC83442.1 - 2.5e-27 93.8 28.7 2.6e-06 27.6 1.1 5.4 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC83442.1 - 2.1e-22 77.8 27.6 6.8e-05 23.4 0.8 5.5 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC83442.1 - 1.4e-21 75.9 25.8 1.9e-07 31.2 0.4 5.5 5 0 0 5 5 5 5 Zinc-finger double domain zf-C2H2_6 PF13912.6 EMC83442.1 - 6.2e-14 51.6 31.8 0.0014 18.5 1.5 5.7 5 1 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC83442.1 - 7.5e-11 42.0 18.4 0.033 14.5 0.1 5.7 6 0 0 6 6 5 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC83442.1 - 2.9e-07 30.7 21.9 0.051 14.0 0.2 5.6 5 0 0 5 5 5 2 Zinc-finger of C2H2 type XPA_N PF01286.18 EMC83442.1 - 2.5e-05 24.2 15.3 0.78 9.8 2.0 5.2 5 0 0 5 5 5 2 XPA protein N-terminal zf-C2H2_11 PF16622.5 EMC83442.1 - 3.3e-05 23.5 24.2 0.4 10.5 2.6 5.3 5 0 0 5 5 5 2 zinc-finger C2H2-type ADK_lid PF05191.14 EMC83442.1 - 0.00013 21.9 8.2 0.023 14.7 1.5 3.9 2 2 1 3 3 3 1 Adenylate kinase, active site lid zf_UBZ PF18439.1 EMC83442.1 - 0.0003 20.3 11.3 3.8 7.2 0.1 5.3 5 0 0 5 5 5 1 Ubiquitin-Binding Zinc Finger zf-Di19 PF05605.12 EMC83442.1 - 0.00043 20.5 22.3 0.0021 18.3 3.8 3.8 1 1 4 5 5 5 4 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.10 EMC83442.1 - 0.00061 19.9 18.7 0.6 10.3 0.2 4.5 3 2 1 4 4 4 1 Zinc ribbon domain zinc_ribbon_15 PF17032.5 EMC83442.1 - 0.0056 17.4 14.2 0.031 15.0 1.0 3.0 2 1 0 2 2 2 1 zinc-ribbon family HypA PF01155.19 EMC83442.1 - 0.0057 16.7 13.9 0.22 11.6 1.1 3.3 1 1 2 3 3 3 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-BED PF02892.15 EMC83442.1 - 0.017 15.1 22.4 0.048 13.7 1.0 5.1 1 1 4 5 5 5 0 BED zinc finger zf-C2H2_2 PF12756.7 EMC83442.1 - 0.035 14.5 22.3 3.7 7.9 0.2 4.8 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) DUF2256 PF10013.9 EMC83442.1 - 0.04 14.0 10.3 25 5.1 0.0 5.0 5 0 0 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2256) C1_4 PF07975.12 EMC83442.1 - 0.061 13.6 14.8 0.82 9.9 2.6 3.6 2 1 1 3 3 3 0 TFIIH C1-like domain PknG_rubred PF16919.5 EMC83442.1 - 0.12 12.6 13.8 0.85 9.8 1.1 3.9 1 1 3 4 4 4 0 Protein kinase G rubredoxin domain PyrI_C PF02748.15 EMC83442.1 - 0.16 11.9 4.3 7.2 6.6 0.2 3.6 4 0 0 4 4 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain FYVE PF01363.21 EMC83442.1 - 0.17 12.0 25.3 0.57 10.4 4.0 3.9 1 1 2 3 3 3 0 FYVE zinc finger DUF2310 PF10071.9 EMC83442.1 - 0.18 11.1 9.2 0.26 10.5 0.1 3.1 2 1 1 3 3 3 0 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310) zf-C2HC_2 PF13913.6 EMC83442.1 - 0.19 11.7 23.0 4.6 7.3 0.4 5.3 5 0 0 5 5 5 0 zinc-finger of a C2HC-type zinc-ribbons_6 PF07191.12 EMC83442.1 - 0.23 11.4 16.1 11 6.1 4.8 3.6 1 1 1 2 2 2 0 zinc-ribbons zf-LYAR PF08790.11 EMC83442.1 - 0.29 11.1 9.7 8.5 6.4 0.2 4.3 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger YhfH PF14149.6 EMC83442.1 - 0.31 11.0 14.7 24 5.0 0.1 5.1 5 0 0 5 5 5 0 YhfH-like protein CpXC PF14353.6 EMC83442.1 - 0.34 11.0 16.9 1.8 8.7 0.2 4.7 1 1 2 4 4 4 0 CpXC protein Ogr_Delta PF04606.12 EMC83442.1 - 0.37 10.8 16.7 1.6 8.7 0.8 3.6 3 0 0 3 3 3 0 Ogr/Delta-like zinc finger TerY_C PF15616.6 EMC83442.1 - 0.52 10.4 8.8 1.8 8.7 0.5 3.0 1 1 2 3 3 3 0 TerY-C metal binding domain zf-ribbon_3 PF13248.6 EMC83442.1 - 0.52 9.8 17.9 4 7.0 0.2 4.7 5 0 0 5 5 5 0 zinc-ribbon domain zinc_ribbon_9 PF14369.6 EMC83442.1 - 0.63 10.4 8.9 36 4.7 0.1 4.5 5 0 0 5 5 4 0 zinc-ribbon zinc_ribbon_4 PF13717.6 EMC83442.1 - 0.65 10.0 20.4 5.3 7.1 0.2 5.1 4 1 0 4 4 4 0 zinc-ribbon domain DUF3797 PF12677.7 EMC83442.1 - 0.75 9.7 4.6 5.5 7.0 0.1 3.0 3 0 0 3 3 2 0 Domain of unknown function (DUF3797) zf-C2H2_9 PF16293.5 EMC83442.1 - 1 9.3 8.6 3.3 7.6 0.6 3.6 2 2 1 3 3 3 0 C2H2 type zinc-finger (1 copy) Zn_Tnp_IS1595 PF12760.7 EMC83442.1 - 1.1 9.2 26.7 4.1 7.4 8.5 4.2 1 1 2 4 4 4 0 Transposase zinc-ribbon domain DUF1610 PF07754.11 EMC83442.1 - 1.3 9.0 9.3 1.3 9.0 0.2 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1610) DUF3268 PF11672.8 EMC83442.1 - 1.3 9.3 10.3 3.7 7.9 0.9 2.4 2 1 0 2 2 2 0 zinc-finger-containing domain zf-FPG_IleRS PF06827.14 EMC83442.1 - 2.5 8.0 12.9 19 5.2 0.2 4.8 5 0 0 5 5 5 0 Zinc finger found in FPG and IleRS zf-C2HE PF16278.5 EMC83442.1 - 3.3 8.2 18.9 0.98 9.9 0.5 4.2 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger DUF983 PF06170.12 EMC83442.1 - 6.8 7.2 15.0 16 6.0 0.0 4.7 5 0 0 5 5 5 0 Protein of unknown function (DUF983) zf-C2H2_3 PF13878.6 EMC83442.1 - 6.8 6.6 22.9 3 7.7 2.5 5.2 4 1 1 5 5 5 0 zinc-finger of acetyl-transferase ESCO MqsA_antitoxin PF15731.5 EMC83442.1 - 7.4 6.7 7.2 81 3.3 0.0 3.3 1 1 1 2 2 2 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA FOXP-CC PF16159.5 EMC83442.1 - 8.2 7.1 9.5 9.2 7.0 0.2 2.9 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-AN1 PF01428.16 EMC83442.1 - 8.3 6.7 24.6 19 5.5 0.1 5.7 5 1 0 5 5 5 0 AN1-like Zinc finger IBR PF01485.21 EMC83442.1 - 8.4 6.7 22.2 2.9 8.2 3.2 3.8 1 1 1 2 2 1 0 IBR domain, a half RING-finger domain DUF1011 PF06237.12 EMC83443.1 - 1.5e-40 137.5 8.7 1.5e-40 137.5 8.7 3.4 4 1 1 5 5 5 1 Protein of unknown function (DUF1011) Furin-like_2 PF15913.5 EMC83444.1 - 1.7e-18 66.7 10.9 1.7e-18 66.7 10.9 1.6 2 0 0 2 2 2 1 Furin-like repeat, cysteine-rich PI31_Prot_N PF11566.8 EMC83445.1 - 1.6e-16 60.5 0.0 2.3e-16 60.0 0.0 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 EMC83445.1 - 1.9e-08 35.4 14.6 3.9e-08 34.4 13.9 1.9 1 1 0 1 1 1 1 PI31 proteasome regulator Syntaphilin PF15290.6 EMC83447.1 - 3.8e-138 460.4 0.0 5.8e-138 459.8 0.0 1.3 1 0 0 1 1 1 1 Golgi-localised syntaxin-1-binding clamp CALCOCO1 PF07888.11 EMC83447.1 - 0.00027 20.0 8.6 0.00036 19.5 8.6 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Fez1 PF06818.15 EMC83447.1 - 0.0017 18.9 8.7 0.0028 18.2 8.7 1.3 1 0 0 1 1 1 1 Fez1 Exonuc_VII_L PF02601.15 EMC83447.1 - 0.013 15.1 3.7 0.02 14.5 3.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Sec8_exocyst PF04048.14 EMC83447.1 - 0.015 15.2 6.6 0.65 9.9 0.2 2.2 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain Sec2p PF06428.11 EMC83447.1 - 0.027 14.4 2.2 0.027 14.4 2.2 2.4 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p Lebercilin PF15619.6 EMC83447.1 - 0.029 14.0 11.5 0.053 13.2 11.5 1.4 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease MPS2 PF17060.5 EMC83447.1 - 0.037 13.3 4.3 0.078 12.2 4.2 1.5 1 1 0 1 1 1 0 Monopolar spindle protein 2 Spc7 PF08317.11 EMC83447.1 - 0.071 12.0 10.3 0.12 11.2 10.3 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein PKcGMP_CC PF16808.5 EMC83447.1 - 0.09 12.7 14.7 0.042 13.7 6.0 3.1 2 1 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase AAA_13 PF13166.6 EMC83447.1 - 0.092 11.4 5.4 0.12 11.0 5.4 1.1 1 0 0 1 1 1 0 AAA domain FAM76 PF16046.5 EMC83447.1 - 0.097 12.0 10.2 0.62 9.4 0.5 2.1 1 1 1 2 2 2 0 FAM76 protein DUF3584 PF12128.8 EMC83447.1 - 0.13 9.8 8.3 0.17 9.4 8.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) BST2 PF16716.5 EMC83447.1 - 0.15 12.6 10.9 0.11 13.1 8.9 1.7 1 1 0 1 1 1 0 Bone marrow stromal antigen 2 ArAE_1_C PF11728.8 EMC83447.1 - 0.16 11.9 6.4 0.25 11.3 6.4 1.2 1 0 0 1 1 1 0 Putative aromatic acid exporter C-terminal domain CcdA PF07362.12 EMC83447.1 - 0.18 12.2 1.4 0.39 11.2 1.4 1.5 1 0 0 1 1 1 0 Post-segregation antitoxin CcdA TPR_MLP1_2 PF07926.12 EMC83447.1 - 0.21 11.6 12.1 2.7 8.1 3.3 1.8 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein HMMR_N PF15905.5 EMC83447.1 - 0.26 10.7 12.8 0.41 10.1 12.8 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Laminin_II PF06009.12 EMC83447.1 - 0.28 11.2 3.6 0.5 10.4 3.6 1.3 1 0 0 1 1 1 0 Laminin Domain II ING PF12998.7 EMC83447.1 - 0.32 11.6 7.9 0.27 11.8 6.1 1.7 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding DUF16 PF01519.16 EMC83447.1 - 0.38 11.3 9.5 5.8 7.5 9.5 2.1 1 1 0 1 1 1 0 Protein of unknown function DUF16 DUF4407 PF14362.6 EMC83447.1 - 0.53 9.6 3.8 0.79 9.0 3.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UPF0242 PF06785.11 EMC83447.1 - 0.54 10.3 10.3 0.83 9.7 10.3 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF641 PF04859.12 EMC83447.1 - 0.69 10.2 8.4 0.079 13.3 0.9 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) FapA PF03961.13 EMC83447.1 - 0.98 7.9 5.3 1.4 7.4 5.3 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF745 PF05335.13 EMC83447.1 - 1.1 9.0 6.5 1.6 8.4 6.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) TMPIT PF07851.13 EMC83447.1 - 1.2 8.4 4.5 1.6 7.9 4.5 1.2 1 0 0 1 1 1 0 TMPIT-like protein CC2-LZ PF16516.5 EMC83447.1 - 1.3 9.4 12.2 0.5 10.8 2.9 2.2 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF4200 PF13863.6 EMC83447.1 - 1.7 9.1 12.8 2 8.9 3.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Golgin_A5 PF09787.9 EMC83447.1 - 1.9 7.9 12.4 4.5 6.6 12.4 1.6 1 1 0 1 1 1 0 Golgin subfamily A member 5 FlaC_arch PF05377.11 EMC83447.1 - 3.1 8.3 5.8 4.4 7.8 1.7 2.4 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) HR1 PF02185.16 EMC83447.1 - 3.8 7.7 11.3 1.5 8.9 1.6 2.6 1 1 2 3 3 3 0 Hr1 repeat Mto2_bdg PF12808.7 EMC83447.1 - 7.2 7.0 9.6 0.83 10.0 2.2 3.0 3 0 0 3 3 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Csm1_N PF18504.1 EMC83447.1 - 9.5 6.6 11.5 3.4 8.1 1.6 2.9 1 1 2 3 3 3 0 Csm1 N-terminal domain PDZ_6 PF17820.1 EMC83448.1 - 9.5e-25 86.2 0.3 6.1e-16 58.0 0.0 2.5 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 EMC83448.1 - 2.9e-21 75.6 3.5 2.7e-12 46.9 0.0 2.7 2 1 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 EMC83448.1 - 1.6e-10 41.1 0.3 4.6e-07 30.1 0.0 2.3 1 1 1 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 EMC83448.1 - 0.0019 18.1 0.2 2.4 8.2 0.1 2.5 2 0 0 2 2 2 2 Tricorn protease PDZ domain FKBP_C PF00254.28 EMC83449.1 - 6.1e-29 100.2 0.0 6.7e-29 100.1 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase MFS_2 PF13347.6 EMC83450.1 - 8.7e-92 307.9 22.5 9.9e-92 307.7 22.5 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1 PF07690.16 EMC83450.1 - 0.34 9.8 39.6 0.0087 15.0 32.0 2.1 2 1 0 2 2 2 0 Major Facilitator Superfamily SEP PF08059.13 EMC83451.1 - 1.2e-26 93.0 0.2 2.7e-26 91.9 0.1 1.7 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 EMC83451.1 - 8.6e-20 70.7 0.1 1.9e-19 69.6 0.1 1.6 1 0 0 1 1 1 1 UBX domain C1-set PF07654.15 EMC83452.1 - 1.2e-29 102.5 0.2 1.2e-15 57.7 0.6 3.6 4 1 0 4 4 4 3 Immunoglobulin C1-set domain Ig_3 PF13927.6 EMC83452.1 - 1.4e-24 86.5 2.8 9.6e-11 42.1 0.1 3.6 3 1 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 EMC83452.1 - 5.4e-20 71.3 0.2 1.1e-08 35.0 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain C2-set_2 PF08205.12 EMC83452.1 - 8.3e-20 70.7 0.6 4e-10 39.6 0.1 3.2 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain ig PF00047.25 EMC83452.1 - 2.2e-19 69.4 3.1 6.8e-09 35.8 0.1 3.7 3 2 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 EMC83452.1 - 1.1e-17 64.1 0.7 4.1e-06 27.0 0.1 3.4 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 EMC83452.1 - 2.3e-16 59.9 1.3 1.9e-13 50.5 0.1 3.2 3 1 0 3 3 3 2 Immunoglobulin V-set domain C2-set PF05790.15 EMC83452.1 - 0.035 14.3 0.2 0.26 11.5 0.1 2.5 2 0 0 2 2 2 0 Immunoglobulin C2-set domain Ig_6 PF18452.1 EMC83452.1 - 0.042 13.4 0.0 0.37 10.4 0.0 2.4 3 0 0 3 3 3 0 Immunoglobulin domain Pilin PF00114.19 EMC83452.1 - 0.13 13.2 0.4 1.5 9.8 0.1 2.7 2 2 1 3 3 3 0 Pilin (bacterial filament) V-set PF07686.17 EMC83453.1 - 6.7e-15 55.2 0.0 1.2e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC83453.1 - 1.8e-12 47.7 0.3 1.1e-11 45.1 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 EMC83453.1 - 9.6e-10 38.5 0.0 1.9e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC83453.1 - 1.1e-09 38.2 0.0 1.9e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC83453.1 - 8.3e-06 26.1 0.0 2.1e-05 24.7 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain Adeno_E3_CR2 PF02439.15 EMC83453.1 - 0.0099 15.6 0.3 0.018 14.8 0.3 1.4 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 Insulin_TMD PF17870.1 EMC83453.1 - 0.019 15.0 0.0 0.033 14.3 0.0 1.3 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF4578 PF15147.6 EMC83453.1 - 0.033 15.1 0.0 0.13 13.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4578) Ig_6 PF18452.1 EMC83453.1 - 0.12 12.0 0.0 0.3 10.7 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain Tweety PF04906.13 EMC83453.1 - 0.15 10.7 0.1 0.2 10.3 0.1 1.1 1 0 0 1 1 1 0 Tweety LST1 PF05083.13 EMC83453.1 - 0.72 10.2 0.0 0.72 10.2 0.0 2.2 3 0 0 3 3 3 0 LST-1 protein C1-set PF07654.15 EMC83454.1 - 3.3e-30 104.3 0.2 7.8e-16 58.2 0.5 3.6 4 1 0 4 4 4 3 Immunoglobulin C1-set domain Ig_3 PF13927.6 EMC83454.1 - 9.2e-24 83.9 3.5 1e-10 42.1 0.1 3.5 3 1 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.12 EMC83454.1 - 1.6e-20 73.0 0.6 2.5e-10 40.3 0.1 3.2 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain I-set PF07679.16 EMC83454.1 - 3e-19 68.8 0.2 1.5e-08 34.6 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 EMC83454.1 - 1.6e-18 66.7 1.9 1e-08 35.2 0.1 3.5 3 1 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 EMC83454.1 - 6e-16 58.6 0.5 1.6e-05 25.2 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 EMC83454.1 - 7.4e-16 58.3 1.3 6.6e-14 52.0 0.1 3.0 3 1 0 3 3 3 1 Immunoglobulin V-set domain Ig_6 PF18452.1 EMC83454.1 - 0.032 13.8 0.1 0.3 10.7 0.0 2.5 3 0 0 3 3 3 0 Immunoglobulin domain Lep_receptor_Ig PF06328.11 EMC83454.1 - 0.089 12.8 0.6 9.4 6.3 0.0 3.2 3 0 0 3 3 3 0 Ig-like C2-type domain Opiods_neuropep PF01160.18 EMC83455.1 - 3.1e-16 59.2 5.9 4.7e-16 58.6 5.9 1.3 1 0 0 1 1 1 1 Vertebrate endogenous opioids neuropeptide Op_neuropeptide PF08035.11 EMC83455.1 - 0.077 12.9 7.9 3.6 7.5 0.0 4.0 4 0 0 4 4 4 0 Opioids neuropeptide DUF5581 PF17744.1 EMC83457.1 - 1.6e-109 366.0 3.4 1.8e-109 365.9 3.4 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5581) fn3 PF00041.21 EMC83457.1 - 0.00093 19.5 0.0 0.0019 18.5 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain TBCC_N PF16752.5 EMC83457.1 - 0.084 13.3 2.2 0.092 13.2 0.5 1.8 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain AAA_11 PF13086.6 EMC83458.1 - 4.4e-71 239.7 1.2 1e-50 173.0 0.1 3.9 2 2 0 3 3 3 3 AAA domain AAA_12 PF13087.6 EMC83458.1 - 8.2e-71 237.7 0.3 2.9e-44 151.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain RNB PF00773.19 EMC83458.1 - 2e-57 195.0 0.1 4.3e-57 193.9 0.1 1.6 1 0 0 1 1 1 1 RNB domain AAA_30 PF13604.6 EMC83458.1 - 4e-18 65.8 0.0 3.2e-05 23.8 0.0 3.7 3 1 0 3 3 3 3 AAA domain AAA_19 PF13245.6 EMC83458.1 - 5.7e-17 62.4 0.0 1.1e-08 35.5 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.6 EMC83458.1 - 2.7e-07 31.0 0.0 0.013 15.7 0.0 4.0 3 1 0 3 3 3 2 AAA domain ResIII PF04851.15 EMC83458.1 - 2.9e-06 27.4 0.0 0.019 15.0 0.0 3.0 3 0 0 3 3 2 2 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 EMC83458.1 - 3.6e-06 26.7 0.0 0.0023 17.5 0.1 3.1 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain PhoH PF02562.16 EMC83458.1 - 3.7e-06 26.5 0.1 0.9 9.0 0.0 4.2 4 0 0 4 4 4 2 PhoH-like protein Viral_helicase1 PF01443.18 EMC83458.1 - 8.5e-06 25.7 0.5 0.091 12.5 0.0 4.7 3 2 1 5 5 5 1 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.6 EMC83458.1 - 9.2e-06 25.4 0.1 0.00069 19.4 0.0 3.2 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain UvrD_C PF13361.6 EMC83458.1 - 0.00024 20.6 0.0 0.24 10.7 0.0 2.8 2 1 0 2 2 2 2 UvrD-like helicase C-terminal domain DUF2075 PF09848.9 EMC83458.1 - 0.00064 19.1 0.0 0.0083 15.4 0.0 2.7 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 EMC83458.1 - 0.00085 19.7 0.0 1.5 9.2 0.0 3.1 3 0 0 3 3 3 1 AAA ATPase domain AAA PF00004.29 EMC83458.1 - 0.002 18.6 0.0 3.8 7.9 0.0 3.1 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 EMC83458.1 - 0.0025 16.9 0.1 0.41 9.7 0.0 2.7 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_24 PF13479.6 EMC83458.1 - 0.017 14.8 0.1 1.6 8.4 0.0 3.4 4 0 0 4 4 4 0 AAA domain OB_Dis3 PF17849.1 EMC83458.1 - 0.032 14.3 0.0 0.12 12.5 0.0 2.1 1 0 0 1 1 1 0 Dis3-like cold-shock domain 2 (CSD2) AAA_7 PF12775.7 EMC83458.1 - 0.043 13.3 0.0 8.2 5.9 0.0 2.8 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_5 PF07728.14 EMC83458.1 - 0.053 13.5 0.0 16 5.5 0.0 2.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DEAD PF00270.29 EMC83458.1 - 0.058 13.2 0.0 10 5.8 0.0 2.7 3 0 0 3 3 3 0 DEAD/DEAH box helicase Bac_DnaA PF00308.18 EMC83458.1 - 0.078 12.8 0.0 0.21 11.4 0.0 1.7 1 0 0 1 1 1 0 Bacterial dnaA protein Helicase_RecD PF05127.14 EMC83458.1 - 0.083 12.7 0.0 1.1 9.1 0.0 2.9 3 0 0 3 3 3 0 Helicase Sigma54_activat PF00158.26 EMC83458.1 - 0.18 11.5 0.0 4.5 6.9 0.0 2.6 3 0 0 3 3 3 0 Sigma-54 interaction domain SAND PF01342.21 EMC83459.1 - 3.1e-24 84.5 0.0 6.1e-24 83.5 0.0 1.5 1 0 0 1 1 1 1 SAND domain KfrA_N PF11740.8 EMC83459.1 - 2.6 8.7 7.9 0.25 12.0 1.6 2.3 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term Stathmin PF00836.19 EMC83460.1 - 1.6e-52 177.0 19.5 2e-52 176.8 19.5 1.1 1 0 0 1 1 1 1 Stathmin family HrpF PF06266.12 EMC83460.1 - 0.12 12.7 0.4 0.25 11.7 0.4 1.5 1 0 0 1 1 1 0 HrpF protein Exonuc_VII_L PF02601.15 EMC83460.1 - 0.6 9.6 8.2 0.67 9.5 8.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit UPF0242 PF06785.11 EMC83460.1 - 1.4 9.0 13.5 1.8 8.6 13.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus KNOX2 PF03791.13 EMC83460.1 - 4.1 7.0 7.5 1.1 8.9 0.1 2.8 2 1 1 3 3 3 0 KNOX2 domain DEAD_2 PF06733.15 EMC83461.1 - 9.2e-54 181.7 6.0 2.2e-53 180.5 6.0 1.7 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.6 EMC83461.1 - 2.1e-52 177.8 0.0 1.3e-51 175.1 0.0 2.4 2 0 0 2 2 2 1 Helicase C-terminal domain ResIII PF04851.15 EMC83461.1 - 2.6e-07 30.8 3.0 0.0035 17.3 0.0 3.5 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit DEAD PF00270.29 EMC83461.1 - 1.1e-05 25.2 0.0 0.0024 17.7 0.0 2.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase SNF2_N PF00176.23 EMC83461.1 - 0.00012 20.9 0.1 0.00049 18.9 0.1 1.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain CDK2AP PF09806.9 EMC83461.1 - 0.31 11.1 2.6 0.82 9.7 2.6 1.7 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein CCM2_C PF16545.5 EMC83461.1 - 0.32 11.5 3.6 0.61 10.6 0.4 2.6 2 0 0 2 2 2 0 Cerebral cavernous malformation protein, harmonin-homology TNFR_c6 PF00020.18 EMC83462.1 - 3.7e-19 68.8 30.5 1.3e-10 41.4 8.6 3.1 3 0 0 3 3 3 3 TNFR/NGFR cysteine-rich region Ephrin_rec_like PF07699.13 EMC83462.1 - 0.0016 18.2 6.6 0.0016 18.2 6.6 3.3 2 2 1 3 3 3 1 Putative ephrin-receptor like RANK_CRD_2 PF18278.1 EMC83462.1 - 0.0027 17.8 2.3 0.0027 17.8 2.3 2.4 2 1 0 3 3 3 1 Receptor activator of the NF-KB cysteine-rich repeat domain 2 Ribosomal_S27 PF01599.19 EMC83462.1 - 0.0044 17.2 0.5 0.0044 17.2 0.5 2.3 2 0 0 2 2 2 1 Ribosomal protein S27a Arf PF00025.21 EMC83463.1 - 2.4e-46 157.4 0.1 3.1e-46 157.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EMC83463.1 - 7.5e-15 54.9 0.1 9.6e-15 54.6 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC83463.1 - 1.6e-14 54.2 0.1 2.1e-14 53.8 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EMC83463.1 - 9.5e-11 41.4 0.1 2e-06 27.2 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EMC83463.1 - 1.7e-10 40.6 0.0 2.1e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EMC83463.1 - 4.2e-08 33.3 0.0 5.7e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMC83463.1 - 3.6e-07 29.8 0.0 4.4e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_18 PF13238.6 EMC83463.1 - 0.047 14.2 0.0 0.071 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain G-patch PF01585.23 EMC83464.1 - 4.8e-12 45.6 0.1 1.1e-11 44.5 0.1 1.6 1 0 0 1 1 1 1 G-patch domain zf-CCCH_4 PF18044.1 EMC83464.1 - 1.8e-05 24.4 4.6 3.8e-05 23.4 4.6 1.6 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EMC83464.1 - 0.00025 21.0 3.0 0.00062 19.7 3.0 1.7 1 0 0 1 1 1 1 Zinc finger domain Med21 PF11221.8 EMC83464.1 - 0.0025 18.1 0.6 0.0025 18.1 0.6 2.5 2 1 0 2 2 2 1 Subunit 21 of Mediator complex Tudor_2 PF18104.1 EMC83464.1 - 0.0048 16.5 0.0 0.014 15.1 0.0 1.8 1 0 0 1 1 1 1 Jumonji domain-containing protein 2A Tudor domain Agenet PF05641.12 EMC83464.1 - 0.0082 16.6 1.8 0.013 16.0 0.0 2.2 2 0 0 2 2 2 1 Agenet domain zf-CCCH_2 PF14608.6 EMC83464.1 - 0.33 11.5 6.1 0.69 10.5 6.1 1.6 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf-CCCH PF00642.24 EMC83464.1 - 0.43 10.6 2.7 0.83 9.6 2.7 1.5 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) IFT20 PF14931.6 EMC83464.1 - 0.6 10.3 11.1 0.73 10.0 8.3 2.3 2 0 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 LIME1 PF15332.6 EMC83465.1 - 0.0012 18.5 1.6 0.097 12.3 1.1 2.8 2 1 0 2 2 2 2 Lck-interacting transmembrane adapter 1 PAG PF15347.6 EMC83465.1 - 0.0033 16.5 0.1 0.021 13.8 0.1 2.2 2 1 0 2 2 2 1 Phosphoprotein associated with glycosphingolipid-enriched zf-C2H2 PF00096.26 EMC83466.1 - 0.0024 18.3 0.4 0.006 17.0 0.4 1.7 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC83466.1 - 0.026 15.3 2.0 0.032 15.1 0.6 1.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 EMC83466.1 - 0.22 11.7 0.0 0.32 11.1 0.0 1.2 1 0 0 1 1 1 0 Aberrant zinc-finger Nop14 PF04147.12 EMC83466.1 - 7.5 4.6 7.9 9.5 4.3 7.9 1.1 1 0 0 1 1 1 0 Nop14-like family BTB PF00651.31 EMC83467.1 - 1.8e-25 89.3 1.1 2.8e-25 88.7 1.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 EMC83467.1 - 3.6e-14 52.4 17.1 1.5e-09 37.8 1.0 3.8 3 0 0 3 3 3 3 Zinc-finger double domain zf-H2C2_5 PF13909.6 EMC83467.1 - 1.2e-08 34.5 3.7 1.2e-08 34.5 3.7 2.7 2 0 0 2 2 2 1 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 EMC83467.1 - 1e-07 32.0 20.4 7.8e-05 22.9 2.4 4.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC83467.1 - 4.9e-07 30.0 21.6 0.008 16.9 1.7 4.2 4 0 0 4 4 3 3 C2H2-type zinc finger DUF3342 PF11822.8 EMC83467.1 - 3.1e-05 24.1 0.2 6.5e-05 23.1 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) zf-met PF12874.7 EMC83467.1 - 0.00013 22.2 12.6 0.029 14.8 0.1 4.1 3 0 0 3 3 3 2 Zinc-finger of C2H2 type BTB_3 PF16017.5 EMC83467.1 - 0.0042 17.2 0.2 0.0086 16.2 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-Di19 PF05605.12 EMC83467.1 - 0.023 15.0 7.7 0.023 15.0 7.7 3.8 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding DUF4428 PF14471.6 EMC83467.1 - 3.9 7.5 8.9 0.11 12.5 0.7 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4428) zf-C2H2_jaz PF12171.8 EMC83467.1 - 9.1 6.7 13.7 3.4 8.1 0.1 4.1 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding TPD52 PF04201.15 EMC83468.1 - 9.3e-63 210.7 5.3 2.3e-37 128.1 0.3 2.0 1 1 1 2 2 2 2 Tumour protein D52 family Lzipper-MIP1 PF14389.6 EMC83468.1 - 0.088 13.1 1.1 0.18 12.1 0.2 1.9 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 HIP1_clath_bdg PF16515.5 EMC83468.1 - 0.17 12.5 3.4 6.3 7.5 0.5 2.6 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DnaJ PF00226.31 EMC83469.1 - 5.1e-28 97.0 2.5 8.4e-28 96.3 2.5 1.4 1 0 0 1 1 1 1 DnaJ domain EMP70 PF02990.16 EMC83469.1 - 0.095 11.3 0.1 0.12 11.1 0.1 1.1 1 0 0 1 1 1 0 Endomembrane protein 70 Corona_S2 PF01601.16 EMC83469.1 - 2.1 6.7 7.5 2.4 6.6 7.5 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein UPRTase PF14681.6 EMC83470.1 - 1e-73 247.2 0.0 1.5e-73 246.7 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRK PF00485.18 EMC83470.1 - 6.1e-55 186.0 0.0 1.1e-54 185.2 0.0 1.4 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family CPT PF07931.12 EMC83470.1 - 0.00057 19.8 0.0 0.0014 18.5 0.0 1.7 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.6 EMC83470.1 - 0.003 18.1 0.0 0.0088 16.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EMC83470.1 - 0.017 14.4 0.0 0.033 13.5 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_17 PF13207.6 EMC83470.1 - 0.022 15.2 0.2 11 6.4 0.0 2.8 3 0 0 3 3 3 0 AAA domain CoaE PF01121.20 EMC83470.1 - 0.028 14.1 0.7 0.13 12.0 0.3 2.0 2 0 0 2 2 2 0 Dephospho-CoA kinase ABC_tran PF00005.27 EMC83470.1 - 0.042 14.4 0.1 13 6.3 0.0 2.3 2 0 0 2 2 2 0 ABC transporter AAA_33 PF13671.6 EMC83470.1 - 0.074 13.2 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 EMC83470.1 - 0.14 11.9 0.1 14 5.4 0.0 2.3 2 0 0 2 2 2 0 Cytidylate kinase SAM_2 PF07647.17 EMC83473.1 - 2.9e-17 62.5 0.3 4.2e-17 62.0 0.3 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EMC83473.1 - 7.8e-09 35.9 0.2 1.5e-08 34.9 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 EMC83473.1 - 3.4e-05 23.7 0.0 5.8e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain PRP1_N PF06424.12 EMC83474.1 - 2e-47 161.3 9.5 4.9e-47 160.1 9.5 1.7 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 EMC83474.1 - 7.4e-31 104.2 26.4 0.0019 18.9 0.1 13.6 6 3 9 15 15 14 8 Tetratricopeptide repeat TPR_19 PF14559.6 EMC83474.1 - 3.7e-24 85.0 10.5 9.3e-07 29.3 0.1 9.1 7 2 4 11 11 11 5 Tetratricopeptide repeat TPR_17 PF13431.6 EMC83474.1 - 3.7e-12 45.7 0.7 0.14 12.6 0.0 8.9 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMC83474.1 - 8.8e-10 39.1 12.8 0.00081 20.0 0.0 8.2 8 1 0 8 8 8 1 Tetratricopeptide repeat TPR_2 PF07719.17 EMC83474.1 - 1e-09 37.7 12.3 0.079 13.1 0.0 10.0 11 1 1 12 12 11 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMC83474.1 - 1.1e-07 31.5 0.1 0.34 11.2 0.0 7.0 7 0 0 7 7 7 1 Tetratricopeptide repeat Suf PF05843.14 EMC83474.1 - 4e-07 30.3 1.8 0.098 12.6 0.0 5.5 6 0 0 6 6 6 1 Suppressor of forked protein (Suf) TPR_1 PF00515.28 EMC83474.1 - 2.3e-05 24.0 0.6 0.37 10.7 0.0 5.1 6 0 0 6 6 6 2 Tetratricopeptide repeat FAT PF02259.23 EMC83474.1 - 9.3e-05 21.8 15.5 0.075 12.2 0.8 4.6 1 1 2 4 4 4 2 FAT domain TPR_9 PF13371.6 EMC83474.1 - 0.00013 22.1 2.5 19 5.5 0.0 5.7 4 2 1 5 5 5 0 Tetratricopeptide repeat TPR_21 PF09976.9 EMC83474.1 - 0.0055 16.4 7.9 0.29 10.8 1.0 4.5 3 1 1 4 4 4 1 Tetratricopeptide repeat-like domain TPR_12 PF13424.6 EMC83474.1 - 0.012 15.9 6.7 29 5.1 0.1 6.3 5 1 0 6 6 6 0 Tetratricopeptide repeat SURF2 PF05477.11 EMC83474.1 - 0.76 9.4 6.2 48 3.5 0.0 2.4 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) Sox17_18_mid PF12067.8 EMC83477.1 - 7.2e-22 77.2 2.3 7.2e-22 77.2 2.3 2.4 2 0 0 2 2 2 1 Sox 17/18 central domain HMG_box PF00505.19 EMC83477.1 - 7.1e-08 32.8 0.6 1.3e-06 28.7 0.1 2.4 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC83477.1 - 0.0056 17.2 0.4 0.017 15.7 0.0 2.0 2 0 0 2 2 2 1 HMG-box domain TFIIS_M PF07500.14 EMC83478.1 - 6.2e-38 129.7 3.0 6.2e-38 129.7 3.0 1.8 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 EMC83478.1 - 1.7e-18 66.1 8.0 3.4e-18 65.2 8.0 1.5 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 EMC83478.1 - 7.2e-16 58.0 1.3 7.2e-16 58.0 1.3 2.2 3 0 0 3 3 3 1 TFIIS helical bundle-like domain DBD_Tnp_Mut PF03108.15 EMC83478.1 - 0.0024 17.8 0.2 0.0059 16.6 0.2 1.6 1 0 0 1 1 1 1 MuDR family transposase AIM3 PF17096.5 EMC83478.1 - 0.031 15.2 3.5 0.031 15.2 3.5 1.7 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 Glyco_hydro_9 PF00759.19 EMC83478.1 - 0.11 12.0 0.0 0.14 11.6 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 DUF3841 PF12952.7 EMC83478.1 - 0.16 11.8 1.2 0.21 11.3 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3841) RGS PF00615.19 EMC83479.1 - 7.7e-36 122.9 1.1 8.8e-36 122.7 1.1 1.0 1 0 0 1 1 1 1 Regulator of G protein signaling domain 7tm_1 PF00001.21 EMC83480.1 - 4.9e-64 216.2 17.9 7.5e-64 215.6 17.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC83480.1 - 1e-13 51.3 18.9 1.6e-13 50.7 18.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 EMC83480.1 - 3.8e-08 33.0 7.4 3.8e-08 33.0 7.4 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 EMC83480.1 - 8.7e-08 32.2 16.2 6.5e-07 29.4 16.2 1.9 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC83480.1 - 9.2e-07 28.8 17.8 9.2e-07 28.8 17.8 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF4381 PF14316.6 EMC83480.1 - 0.26 11.5 0.0 0.53 10.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) 7tm_1 PF00001.21 EMC83481.1 - 6.8e-55 186.2 23.9 7.9e-55 186.0 23.9 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC83481.1 - 1.8e-14 53.8 21.8 2.2e-14 53.5 21.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 EMC83481.1 - 1.7e-07 30.9 17.7 1.7e-07 30.9 17.7 1.9 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srw PF10324.9 EMC83481.1 - 5.9e-05 22.5 25.6 0.00019 20.8 25.6 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw SK_channel PF03530.14 EMC83481.1 - 0.04 13.9 9.8 0.54 10.3 9.8 2.4 1 1 0 1 1 1 0 Calcium-activated SK potassium channel zf-C2HC PF01530.18 EMC83482.1 - 4.2e-99 324.3 97.1 1.1e-15 57.5 7.2 7.6 7 0 0 7 7 7 7 Zinc finger, C2HC type MYT1 PF08474.11 EMC83482.1 - 1.2e-78 264.5 16.6 6.3e-53 180.2 11.3 4.9 3 2 1 4 4 4 2 Myelin transcription factor 1 DUF1664 PF07889.12 EMC83482.1 - 0.14 12.2 3.0 0.33 11.0 3.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) IBR PF01485.21 EMC83482.1 - 0.28 11.4 28.2 11 6.3 0.3 8.0 6 2 2 8 8 8 0 IBR domain, a half RING-finger domain XhlA PF10779.9 EMC83482.1 - 4.8 7.5 7.9 22 5.4 7.9 2.2 1 1 0 1 1 1 0 Haemolysin XhlA PCMT PF01135.19 EMC83483.1 - 2e-26 93.1 0.0 2.7e-26 92.6 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DOT1 PF08123.13 EMC83483.1 - 0.0003 20.4 0.0 0.00047 19.7 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_31 PF13847.6 EMC83483.1 - 0.00062 19.6 0.0 0.0012 18.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC83483.1 - 0.014 16.1 0.1 0.06 14.1 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain GCD14 PF08704.10 EMC83483.1 - 0.019 14.7 0.0 0.032 13.9 0.0 1.3 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_25 PF13649.6 EMC83483.1 - 0.025 15.3 0.0 0.096 13.4 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain SOCS_box PF07525.16 EMC83483.1 - 0.031 14.6 0.0 0.066 13.6 0.0 1.5 1 0 0 1 1 1 0 SOCS box REV PF00424.18 EMC83483.1 - 0.078 13.0 0.4 0.14 12.2 0.4 1.4 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) HicB_lk_antitox PF15919.5 EMC83483.1 - 0.13 12.4 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 HicB_like antitoxin of bacterial toxin-antitoxin system An_peroxidase PF03098.15 EMC83484.1 - 1.4e-200 667.4 0.0 2e-200 666.9 0.0 1.2 1 0 0 1 1 1 1 Animal haem peroxidase I-set PF07679.16 EMC83484.1 - 4.7e-85 279.8 0.0 8.1e-21 73.9 0.0 4.3 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC83484.1 - 4e-71 235.6 0.9 5.1e-17 62.2 0.1 4.4 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 EMC83484.1 - 6.4e-48 161.0 0.1 3.9e-11 43.1 0.1 4.5 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 EMC83484.1 - 2.3e-37 127.1 0.2 5.4e-09 36.1 0.1 4.4 4 0 0 4 4 4 4 Immunoglobulin domain LRR_8 PF13855.6 EMC83484.1 - 3.1e-36 122.9 24.2 1.8e-17 62.9 4.1 3.6 1 1 2 3 3 3 3 Leucine rich repeat V-set PF07686.17 EMC83484.1 - 1.1e-23 83.4 6.4 0.00022 21.4 0.2 7.9 4 4 0 4 4 4 4 Immunoglobulin V-set domain LRR_4 PF12799.7 EMC83484.1 - 6.2e-16 58.3 18.9 4.3e-06 27.0 0.3 4.9 5 0 0 5 5 5 3 Leucine Rich repeats (2 copies) C2-set_2 PF08205.12 EMC83484.1 - 1.1e-14 54.3 0.3 0.002 18.2 0.0 4.5 4 0 0 4 4 4 4 CD80-like C2-set immunoglobulin domain LRR_5 PF13306.6 EMC83484.1 - 1.4e-12 47.7 0.4 3.5e-12 46.4 0.4 1.7 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) Ig_5 PF16681.5 EMC83484.1 - 3.5e-09 36.9 0.0 0.01 16.2 0.0 4.9 5 0 0 5 5 5 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain LRR_9 PF14580.6 EMC83484.1 - 5.1e-09 35.9 5.3 6.7e-05 22.5 1.8 2.3 1 1 1 2 2 2 2 Leucine-rich repeat Ig_4 PF16680.5 EMC83484.1 - 1.9e-08 34.4 0.0 0.014 15.6 0.1 4.6 4 0 0 4 4 4 1 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 EMC83484.1 - 1.6e-05 24.3 0.0 0.15 11.6 0.0 4.1 4 0 0 4 4 4 2 Immunoglobulin domain Ig_C17orf99 PF17736.1 EMC83484.1 - 7.7e-05 22.7 0.0 0.8 9.8 0.0 4.6 4 2 0 4 4 4 1 C17orf99 Ig domain Izumo-Ig PF16706.5 EMC83484.1 - 0.00018 21.5 0.1 28 4.9 0.0 4.6 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain LRRCT PF01463.24 EMC83484.1 - 0.014 15.8 0.0 0.056 14.0 0.0 2.1 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain B_lectin PF01453.24 EMC83484.1 - 0.02 15.5 0.2 14 6.3 0.0 3.5 4 0 0 4 4 3 0 D-mannose binding lectin LRRNT PF01462.18 EMC83484.1 - 0.16 11.7 3.3 0.56 9.9 3.3 2.0 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain MA-Mit PF09245.10 EMC83484.1 - 0.23 10.9 1.1 0.41 10.1 1.1 1.3 1 0 0 1 1 1 0 Mycoplasma arthritidis-derived mitogen Pkinase_Tyr PF07714.17 EMC83485.1 - 2e-94 315.7 0.0 2.5e-94 315.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC83485.1 - 8.2e-49 166.3 0.0 1.1e-48 165.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 EMC83485.1 - 1.5e-23 82.7 0.0 3.4e-23 81.5 0.0 1.7 1 0 0 1 1 1 1 SH2 domain SH3_9 PF14604.6 EMC83485.1 - 1.2e-09 37.9 0.0 2.8e-09 36.7 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC83485.1 - 6.6e-07 28.8 0.0 1.2e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain Haspin_kinase PF12330.8 EMC83485.1 - 4e-06 26.0 0.1 8.2e-06 25.0 0.1 1.4 1 1 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 EMC83485.1 - 0.00049 19.8 0.1 0.00082 19.0 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 EMC83485.1 - 0.003 16.9 0.0 0.0047 16.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC83485.1 - 0.011 15.0 0.4 0.031 13.6 0.4 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMC83485.1 - 0.14 10.9 0.2 0.18 10.5 0.2 1.2 1 0 0 1 1 1 0 Fungal protein kinase SH3_2 PF07653.17 EMC83485.1 - 0.15 11.8 0.0 0.44 10.3 0.0 1.8 1 0 0 1 1 1 0 Variant SH3 domain PPDFL PF15060.6 EMC83486.1 - 1.3e-44 151.2 3.4 1.4e-44 151.1 3.4 1.0 1 0 0 1 1 1 1 Differentiation and proliferation regulator GTP_EFTU PF00009.27 EMC83487.1 - 2.4e-55 187.1 0.0 3.4e-55 186.6 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EMC83487.1 - 3.8e-40 136.7 0.0 8.2e-40 135.6 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EMC83487.1 - 7.8e-15 55.0 1.4 1.5e-14 54.1 0.4 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EMC83487.1 - 0.00033 20.7 0.2 0.0084 16.2 0.2 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 EMC83487.1 - 0.018 15.0 0.7 0.047 13.6 0.1 2.0 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Dynamin_N PF00350.23 EMC83487.1 - 0.039 14.0 0.1 10 6.1 0.0 2.4 2 0 0 2 2 2 0 Dynamin family G-alpha PF00503.20 EMC83487.1 - 0.19 10.8 0.4 0.55 9.3 0.1 1.8 2 0 0 2 2 2 0 G-protein alpha subunit KCNQ_channel PF03520.14 EMC83488.1 - 4.6e-83 277.7 0.3 1.7e-82 275.9 0.3 1.9 1 1 0 1 1 1 1 KCNQ voltage-gated potassium channel KCNQC3-Ank-G_bd PF11956.8 EMC83488.1 - 4.2e-46 155.5 0.8 9.1e-46 154.4 0.8 1.6 1 0 0 1 1 1 1 Ankyrin-G binding motif of KCNQ2-3 KCNQ2_u3 PF16642.5 EMC83488.1 - 1.5e-36 125.3 10.6 1.5e-36 125.3 10.6 2.1 2 0 0 2 2 2 1 Unstructured region on Potassium channel subunit alpha KvLQT2 Ion_trans PF00520.31 EMC83488.1 - 1.3e-29 103.2 5.6 3.3e-29 101.8 5.7 1.6 2 0 0 2 2 2 1 Ion transport protein Ion_trans_2 PF07885.16 EMC83488.1 - 2.1e-13 50.0 3.1 5.7e-13 48.6 3.1 1.8 1 0 0 1 1 1 1 Ion channel Neur_chan_memb PF02932.16 EMC83489.1 - 1.8e-110 368.7 8.6 8.1e-110 366.5 8.6 1.8 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 EMC83489.1 - 1.7e-75 253.2 3.7 2.4e-75 252.7 3.7 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF2417 PF10329.9 EMC83489.1 - 0.33 10.3 8.6 0.77 9.1 8.6 1.6 1 0 0 1 1 1 0 Region of unknown function (DUF2417) GPR15L PF15854.5 EMC83489.1 - 0.68 10.2 0.1 0.68 10.2 0.1 3.7 4 0 0 4 4 4 0 G-protein coupled receptor ligand 15 Claudin_2 PF13903.6 EMC83489.1 - 0.93 9.2 4.6 0.86 9.3 0.9 2.5 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction fn3 PF00041.21 EMC83490.1 - 5.2e-77 254.2 17.5 1.1e-15 57.7 0.5 6.6 6 0 0 6 6 6 6 Fibronectin type III domain VWA PF00092.28 EMC83490.1 - 1.1e-47 162.6 0.0 2.1e-47 161.6 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Collagen PF01391.18 EMC83490.1 - 6.6e-35 118.7 151.4 1.8e-09 37.2 35.3 5.3 3 2 2 5 5 5 5 Collagen triple helix repeat (20 copies) VWA_2 PF13519.6 EMC83490.1 - 3e-13 50.3 0.0 6.4e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF2369 PF10179.9 EMC83490.1 - 1e-06 29.0 0.1 2.5 8.5 0.0 5.6 5 0 0 5 5 5 2 Uncharacterised conserved protein (DUF2369) Pur_ac_phosph_N PF16656.5 EMC83490.1 - 1.7e-06 28.5 18.4 1.6 9.4 2.0 7.7 6 2 0 6 6 6 3 Purple acid Phosphatase, N-terminal domain CBM_4_9 PF02018.17 EMC83490.1 - 7.3e-05 23.0 0.4 0.014 15.6 0.0 3.2 3 0 0 3 3 3 1 Carbohydrate binding domain DUF4959 PF16323.5 EMC83490.1 - 0.007 16.7 0.1 0.74 10.2 0.0 3.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4959) DUF4998 PF16389.5 EMC83490.1 - 0.0078 15.8 0.0 0.25 10.9 0.0 3.3 4 0 0 4 4 4 1 Domain of unknown function DGF-1_C PF11040.8 EMC83490.1 - 0.16 12.0 0.6 0.51 10.4 0.6 1.8 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DEP PF00610.21 EMC83491.1 - 6.3e-45 151.1 1.3 3.7e-22 78.2 0.1 2.3 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDZ_6 PF17820.1 EMC83491.1 - 1.5e-07 31.1 0.0 2.7e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 EMC83491.1 - 0.038 14.3 0.0 0.082 13.3 0.0 1.6 1 0 0 1 1 1 0 PDZ domain PDZ_2 PF13180.6 EMC83491.1 - 0.043 14.1 0.0 0.12 12.7 0.0 1.7 2 0 0 2 2 2 0 PDZ domain ArfGap PF01412.18 EMC83492.1 - 8.7e-33 112.9 0.5 8.7e-33 112.9 0.5 3.1 4 1 0 4 4 4 1 Putative GTPase activating protein for Arf zf-piccolo PF05715.13 EMC83492.1 - 0.03 14.5 1.4 0.079 13.1 1.4 1.6 1 0 0 1 1 1 0 Piccolo Zn-finger NKAIN PF05640.14 EMC83493.1 - 3.5e-92 307.4 6.4 4e-92 307.2 6.4 1.0 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein DUF1003 PF06210.11 EMC83493.1 - 0.11 12.6 1.4 0.22 11.6 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) BIR PF00653.21 EMC83494.1 - 7.6e-42 141.8 8.0 3e-23 82.3 1.2 3.0 4 0 0 4 4 4 2 Inhibitor of Apoptosis domain zf-C3HC4_3 PF13920.6 EMC83494.1 - 9.8e-15 54.2 8.0 9.8e-15 54.2 8.0 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC83494.1 - 2.8e-06 27.1 7.1 2.8e-06 27.1 7.1 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EMC83494.1 - 0.00098 19.4 8.9 0.00098 19.4 8.9 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC83494.1 - 0.0092 15.8 8.4 0.0092 15.8 8.4 2.5 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) GAGA PF09237.11 EMC83494.1 - 0.023 14.5 0.5 0.057 13.2 0.5 1.6 1 0 0 1 1 1 0 GAGA factor DUF2039 PF10217.9 EMC83494.1 - 0.074 13.4 2.4 0.15 12.4 2.4 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) Vps39_2 PF10367.9 EMC83494.1 - 1.1 9.8 4.4 0.79 10.2 1.2 2.2 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 2 YTH PF04146.15 EMC83495.1 - 4.1e-42 144.0 0.4 1.2e-41 142.4 0.4 1.8 1 1 0 1 1 1 1 YT521-B-like domain HLH PF00010.26 EMC83496.1 - 3.1e-14 52.6 0.4 5e-14 52.0 0.4 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain MFS_1 PF07690.16 EMC83497.1 - 4e-46 157.6 26.8 4e-46 157.6 26.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily CLTH PF10607.9 EMC83498.1 - 2.6e-34 118.3 5.2 3.3e-34 117.9 5.2 1.1 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EMC83498.1 - 1.2e-12 47.3 0.5 4.7e-11 42.2 0.1 2.7 2 0 0 2 2 2 1 LisH HLH PF00010.26 EMC83499.1 - 4.3e-10 39.4 0.1 8.1e-10 38.5 0.1 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Collagen PF01391.18 EMC83500.1 - 5.4e-18 64.5 58.9 2.5e-10 40.0 30.2 2.6 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) OGFr_N PF04664.13 EMC83501.1 - 2.3e-103 344.2 11.0 3.1e-103 343.7 11.0 1.1 1 0 0 1 1 1 1 Opioid growth factor receptor (OGFr) conserved region Eaf7 PF07904.13 EMC83502.1 - 1.4e-07 31.8 4.9 5.9e-07 29.8 4.9 2.4 1 1 0 1 1 1 1 Chromatin modification-related protein EAF7 7tm_1 PF00001.21 EMC83503.1 - 1.2e-11 44.4 14.0 2.5e-11 43.4 14.0 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) FtsX PF02687.21 EMC83503.1 - 6.7 7.3 9.2 0.21 12.1 1.9 2.2 2 1 0 2 2 2 0 FtsX-like permease family 7tm_1 PF00001.21 EMC83504.1 - 4.7e-27 95.0 5.6 5.1e-27 94.8 5.6 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC83504.1 - 9.6e-07 28.8 2.6 1e-06 28.7 2.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC83504.1 - 1.2e-06 28.4 6.0 1.8e-06 27.8 6.0 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 EMC83504.1 - 0.00012 21.5 5.1 0.00014 21.3 5.1 1.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv OATP PF03137.20 EMC83505.1 - 2.8e-176 587.0 12.3 3.7e-176 586.6 12.3 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 EMC83505.1 - 2.7e-15 56.2 25.9 2.7e-15 56.2 25.9 3.1 2 2 0 2 2 2 1 Major Facilitator Superfamily Kazal_2 PF07648.15 EMC83505.1 - 7.8e-09 35.5 10.5 2.7e-08 33.8 10.5 2.0 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EMC83505.1 - 0.054 13.5 6.7 0.18 11.8 6.7 1.9 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain DUF1294 PF06961.13 EMC83505.1 - 0.084 13.1 0.0 0.39 11.0 0.0 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1294) CtIP_N PF10482.9 EMC83507.1 - 2.3e-54 182.5 19.5 2.3e-54 182.5 19.5 1.8 2 0 0 2 2 2 1 Tumour-suppressor protein CtIP N-terminal domain NRBF2 PF08961.10 EMC83507.1 - 0.017 14.7 3.2 0.017 14.7 3.2 3.0 2 1 1 3 3 3 0 Nuclear receptor-binding factor 2, autophagy regulator DivIC PF04977.15 EMC83507.1 - 0.017 14.9 9.6 0.13 12.0 0.2 2.9 2 1 0 2 2 2 0 Septum formation initiator Atg14 PF10186.9 EMC83507.1 - 0.02 14.0 8.8 0.039 13.0 8.8 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ZapB PF06005.12 EMC83507.1 - 0.071 13.6 0.5 0.071 13.6 0.5 2.9 3 0 0 3 3 3 0 Cell division protein ZapB bZIP_1 PF00170.21 EMC83507.1 - 0.26 11.4 14.7 0.37 10.9 1.1 3.2 3 0 0 3 3 3 0 bZIP transcription factor TRPM_tetra PF16519.5 EMC83507.1 - 0.49 10.5 4.8 7.4 6.8 0.1 2.7 2 0 0 2 2 2 0 Tetramerisation domain of TRPM SKA2 PF16740.5 EMC83507.1 - 1.5 8.6 11.6 6.4 6.6 2.3 2.7 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 HI0933_like PF03486.14 EMC83507.1 - 1.7 7.2 5.0 2.7 6.6 5.0 1.2 1 0 0 1 1 1 0 HI0933-like protein TSC22 PF01166.18 EMC83507.1 - 1.7 9.0 13.6 0.61 10.4 0.8 3.6 3 1 1 4 4 4 0 TSC-22/dip/bun family JIP_LZII PF16471.5 EMC83507.1 - 3.2 8.0 11.3 1.9 8.7 0.5 3.0 2 1 2 4 4 3 0 JNK-interacting protein leucine zipper II DivIVA PF05103.13 EMC83507.1 - 4.9 7.3 10.2 10 6.2 2.5 2.8 1 1 1 2 2 2 0 DivIVA protein Spc24 PF08286.11 EMC83507.1 - 6.1 7.1 12.0 7.4 6.9 1.3 2.8 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF4618 PF15397.6 EMC83507.1 - 6.9 6.0 17.5 2.5 7.4 3.0 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4618) YabA PF06156.13 EMC83507.1 - 7.8 7.2 17.0 2.5 8.8 2.8 2.9 2 1 1 3 3 3 0 Initiation control protein YabA Cep57_CLD_2 PF14197.6 EMC83507.1 - 9 6.5 15.8 5.1 7.3 1.1 3.0 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Cyclin_N PF00134.23 EMC83508.1 - 2.1e-09 37.2 0.5 4e-09 36.3 0.5 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain HGTP_anticodon PF03129.20 EMC83508.1 - 0.15 12.2 0.0 0.7 10.1 0.0 1.9 2 0 0 2 2 2 0 Anticodon binding domain Ribosomal_S21e PF01249.18 EMC83509.1 - 1.5e-22 79.5 0.1 1.6e-22 79.4 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e Proteasom_Rpn13 PF04683.13 EMC83510.1 - 7.4e-34 116.2 0.1 9.5e-34 115.8 0.1 1.1 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor His_binding PF02098.16 EMC83510.1 - 0.058 13.4 0.1 0.072 13.1 0.1 1.1 1 0 0 1 1 1 0 Tick histamine binding protein 7tm_1 PF00001.21 EMC83511.1 - 6.1e-45 153.6 10.6 1.4e-44 152.4 10.6 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SSXT PF05030.12 EMC83512.1 - 1.1e-32 111.5 5.0 3e-32 110.0 5.0 1.8 1 0 0 1 1 1 1 SSXT protein (N-terminal region) Elf4 PF07011.11 EMC83512.1 - 0.071 13.0 1.5 1.3 9.0 0.1 2.4 1 1 1 2 2 2 0 Early Flowering 4 domain FDF PF09532.10 EMC83513.1 - 3.7e-24 85.6 9.0 3.7e-24 85.6 9.0 1.8 2 0 0 2 2 2 1 FDF domain LSM14 PF12701.7 EMC83513.1 - 2.2e-12 46.9 0.0 3.6e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 Scd6-like Sm domain Cadherin PF00028.17 EMC83514.1 - 4e-70 232.3 3.6 7.1e-22 77.7 1.2 5.6 6 0 0 6 6 6 5 Cadherin domain Cadherin_C PF01049.17 EMC83514.1 - 2.9e-47 160.6 0.1 6e-47 159.6 0.1 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_pro PF08758.11 EMC83514.1 - 1.2e-16 60.6 0.0 3e-16 59.4 0.0 1.7 1 0 0 1 1 1 1 Cadherin prodomain like Cadherin_2 PF08266.12 EMC83514.1 - 7.6e-05 22.5 0.0 2.7 7.9 0.0 3.5 3 0 0 3 3 3 2 Cadherin-like He_PIG PF05345.12 EMC83514.1 - 0.00019 21.5 7.5 0.028 14.6 0.3 4.7 5 0 0 5 5 5 1 Putative Ig domain Cadherin_3 PF16184.5 EMC83514.1 - 0.00036 20.5 4.8 4.7 7.3 0.0 4.5 4 0 0 4 4 4 1 Cadherin-like PKD PF00801.20 EMC83514.1 - 0.025 14.4 0.5 1.4 8.8 0.1 3.6 4 0 0 4 4 4 0 PKD domain Stevor PF17410.2 EMC83514.1 - 0.028 14.0 0.2 0.046 13.3 0.2 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame EphA2_TM PF14575.6 EMC83514.1 - 0.049 14.5 0.0 0.12 13.3 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF5527 PF17665.1 EMC83514.1 - 0.14 11.7 1.4 0.2 11.2 0.3 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5527) Cadherin_4 PF17803.1 EMC83514.1 - 1.5 9.5 24.2 0.18 12.5 0.8 5.4 6 0 0 6 6 5 0 Bacterial cadherin-like domain Big_9 PF17963.1 EMC83514.1 - 9.2 7.1 20.1 0.29 11.9 1.1 4.8 5 0 0 5 5 5 0 Bacterial Ig domain FAM217 PF15344.6 EMC83515.1 - 4.6e-84 282.1 4.1 4.6e-84 282.1 4.1 2.0 2 0 0 2 2 2 1 FAM217 family CBM_21 PF03370.13 EMC83516.1 - 2.7e-32 111.3 0.3 4e-32 110.7 0.3 1.3 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 EMC83516.1 - 5.9e-14 52.4 0.6 1.4e-13 51.2 0.6 1.6 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) CBM_25 PF03423.13 EMC83516.1 - 0.0098 16.1 0.0 0.018 15.3 0.0 1.3 1 0 0 1 1 1 1 Carbohydrate binding domain (family 25) SYCP2_ARLD PF18581.1 EMC83517.1 - 3.2e-53 180.2 5.6 3.2e-53 180.2 5.6 1.9 2 1 0 2 2 2 1 Synaptonemal complex 2 armadillo-repeat-like domain SYCP2_SLD PF18584.1 EMC83517.1 - 7.1e-44 148.6 0.1 1.4e-43 147.7 0.1 1.5 1 0 0 1 1 1 1 Synaptonemal complex 2 Spt16M-like domain RhaA PF06134.11 EMC83517.1 - 0.03 13.4 0.0 0.049 12.8 0.0 1.3 1 0 0 1 1 1 0 L-rhamnose isomerase (RhaA) RPEL PF02755.15 EMC83518.1 - 5.7e-21 73.5 21.3 9.7e-07 28.3 3.2 4.7 4 0 0 4 4 4 4 RPEL repeat Sod_Ni PF09055.11 EMC83518.1 - 0.016 15.7 1.0 0.049 14.2 1.0 1.8 1 0 0 1 1 1 0 Nickel-containing superoxide dismutase Endothelin PF00322.17 EMC83519.1 - 0.015 14.9 4.6 0.028 14.0 4.6 1.4 1 0 0 1 1 1 0 Endothelin family DUF3967 PF13152.6 EMC83519.1 - 0.13 12.0 1.1 0.21 11.4 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3967) zf-C2H2 PF00096.26 EMC83522.1 - 7.9e-08 32.4 11.2 3.5e-05 24.0 1.3 3.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC83522.1 - 5.3e-07 29.8 0.3 5.3e-07 29.8 0.3 3.2 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EMC83522.1 - 2.1e-05 24.6 4.7 0.018 15.3 1.3 3.1 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EMC83522.1 - 7.8e-05 23.2 8.0 0.071 14.0 0.3 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-RRN7 PF11781.8 EMC83522.1 - 0.84 9.4 4.1 0.6 9.8 0.2 2.2 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-C2H2_6 PF13912.6 EMC83522.1 - 1.1 9.4 8.2 0.087 12.9 0.6 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger ATPase-cat_bd PF12156.8 EMC83522.1 - 4 8.2 7.8 0.75 10.6 1.0 3.0 3 0 0 3 3 3 0 Putative metal-binding domain of cation transport ATPase PRELI PF04707.14 EMC83524.1 - 6.3e-56 188.6 0.0 7.5e-56 188.3 0.0 1.0 1 0 0 1 1 1 1 PRELI-like family ATP-synt_Eps PF04627.13 EMC83525.1 - 3.4e-13 49.4 2.2 3.7e-13 49.2 2.2 1.0 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain Tubulin PF00091.25 EMC83526.1 - 1.1e-70 237.8 0.0 1.6e-70 237.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EMC83526.1 - 1.3e-40 138.4 0.0 2.1e-40 137.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EMC83526.1 - 2.1e-05 24.8 0.0 5.4e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 EMC83526.1 - 0.0048 16.1 0.0 0.008 15.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin like Tubulin_3 PF14881.6 EMC83526.1 - 0.0048 16.6 0.0 0.0095 15.6 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Peptidase_C1 PF00112.23 EMC83527.1 - 2e-51 175.1 11.9 2.6e-51 174.8 11.9 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EMC83527.1 - 0.071 11.9 0.6 0.15 10.8 0.6 1.5 1 0 0 1 1 1 0 Peptidase C1-like family TH1 PF04858.13 EMC83528.1 - 7.8e-282 936.1 0.8 8.9e-282 935.9 0.8 1.0 1 0 0 1 1 1 1 TH1 protein G-alpha PF00503.20 EMC83529.1 - 4.6e-99 331.9 1.0 5.3e-99 331.7 1.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EMC83529.1 - 1.9e-14 53.5 1.1 1.6e-13 50.5 0.5 2.4 2 0 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.13 EMC83529.1 - 0.00042 20.5 1.2 0.031 14.5 0.2 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EMC83529.1 - 0.13 11.8 0.0 0.35 10.4 0.0 1.9 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Peptidase_M17 PF00883.21 EMC83530.1 - 1.2e-100 336.8 0.1 1.5e-100 336.5 0.1 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Pdase_M17_N2 PF18295.1 EMC83530.1 - 5.4e-16 59.0 0.5 1.7e-15 57.3 0.2 2.0 2 0 0 2 2 2 1 M17 aminopeptidase N-terminal domain 2 SNARE PF05739.19 EMC83531.1 - 1.7e-19 69.6 2.2 1.7e-19 69.6 2.2 2.1 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 EMC83531.1 - 0.0023 17.6 11.9 0.0023 17.6 11.9 2.2 2 1 0 2 2 2 1 Syntaxin DUF2116 PF09889.9 EMC83531.1 - 0.025 14.5 1.0 0.06 13.3 1.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) TRP PF06011.12 EMC83531.1 - 0.027 13.2 0.0 0.03 13.0 0.0 1.1 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel DUF3140 PF11338.8 EMC83531.1 - 0.035 14.5 0.2 0.087 13.3 0.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3140) Use1 PF09753.9 EMC83531.1 - 0.035 13.8 0.3 0.035 13.8 0.3 2.3 2 1 1 3 3 3 0 Membrane fusion protein Use1 ETRAMP PF09716.10 EMC83531.1 - 0.044 13.8 0.0 0.047 13.7 0.0 1.4 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Orf78 PF06024.12 EMC83531.1 - 0.059 13.7 0.5 0.15 12.4 0.5 1.6 1 0 0 1 1 1 0 Orf78 (ac78) Syntaxin_2 PF14523.6 EMC83531.1 - 0.075 13.4 11.0 0.1 13.0 6.1 2.5 2 1 0 2 2 2 0 Syntaxin-like protein DUF5345 PF17280.2 EMC83531.1 - 0.099 12.6 1.9 0.1 12.6 0.1 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5345) T2SSF PF00482.23 EMC83531.1 - 0.1 12.5 4.7 5.2 7.0 0.2 2.6 2 1 0 2 2 2 0 Type II secretion system (T2SS), protein F DUF4191 PF13829.6 EMC83531.1 - 0.11 11.9 2.0 0.12 11.7 0.7 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) Prominin PF05478.11 EMC83531.1 - 0.27 9.2 9.5 0.17 9.8 1.4 2.0 2 0 0 2 2 2 0 Prominin EVI2A PF05399.11 EMC83531.1 - 0.48 10.0 3.4 0.92 9.1 0.2 2.4 2 1 0 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) Synaptobrevin PF00957.21 EMC83531.1 - 0.83 9.5 10.8 0.069 13.0 1.9 3.3 3 1 1 4 4 4 0 Synaptobrevin Syntaxin-6_N PF09177.11 EMC83531.1 - 1.3 9.7 6.7 2.2 8.9 3.7 2.6 2 1 0 2 2 2 0 Syntaxin 6, N-terminal TMPIT PF07851.13 EMC83531.1 - 1.6 7.9 9.8 1.1 8.4 2.7 2.3 2 1 1 3 3 3 0 TMPIT-like protein CCDC-167 PF15188.6 EMC83531.1 - 2.4 8.6 8.9 1.1 9.6 0.1 3.3 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 Motile_Sperm PF00635.26 EMC83532.1 - 3.9e-29 100.7 0.1 7.7e-29 99.7 0.1 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain LcrG PF07216.12 EMC83532.1 - 0.0024 17.8 0.2 0.0041 17.0 0.2 1.4 1 0 0 1 1 1 1 LcrG protein ZapB PF06005.12 EMC83532.1 - 0.0067 16.9 0.4 0.012 16.1 0.4 1.3 1 0 0 1 1 1 1 Cell division protein ZapB IF2_N PF04760.15 EMC83532.1 - 0.062 13.1 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region CHD5 PF04420.14 EMC83532.1 - 0.23 11.3 1.2 0.43 10.4 0.9 1.5 2 0 0 2 2 2 0 CHD5-like protein Ras PF00071.22 EMC83533.1 - 6.8e-56 188.3 0.0 7.8e-56 188.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC83533.1 - 2.5e-36 124.5 0.0 3.9e-36 123.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC83533.1 - 1.9e-14 53.5 0.0 2e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC83533.1 - 3.6e-05 23.8 0.0 7.1e-05 22.9 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMC83533.1 - 7.5e-05 22.2 0.0 9.7e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EMC83533.1 - 0.00012 21.7 0.0 0.00052 19.6 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EMC83533.1 - 0.00037 20.4 0.6 0.13 12.2 0.0 2.4 1 1 0 2 2 2 2 RsgA GTPase AAA_7 PF12775.7 EMC83533.1 - 0.012 15.2 0.0 0.018 14.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 EMC83533.1 - 0.013 15.9 0.0 0.025 15.0 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 EMC83533.1 - 0.051 13.3 0.0 0.1 12.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain DIT1_PvcA PF05141.12 EMC83533.1 - 0.082 12.4 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein CNTF PF01110.17 EMC83533.1 - 0.086 12.2 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Ciliary neurotrophic factor AAA_5 PF07728.14 EMC83533.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) HEAT PF02985.22 EMC83534.1 - 1.3e-24 84.1 15.1 0.0083 16.3 0.0 9.5 9 0 0 9 9 9 7 HEAT repeat HEAT_2 PF13646.6 EMC83534.1 - 3.7e-10 40.1 0.4 0.18 12.2 0.0 7.1 4 2 3 8 8 8 4 HEAT repeats WRNPLPNID PF15017.6 EMC83534.1 - 5e-07 30.5 0.2 5e-07 30.5 0.2 2.4 2 0 0 2 2 2 1 Putative WW-binding domain and destruction box Vac14_Fab1_bd PF12755.7 EMC83534.1 - 0.0007 20.1 1.5 5.3 7.7 0.0 5.4 4 3 2 6 6 6 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EMC83534.1 - 0.0021 18.2 8.5 6.7 6.7 0.1 5.8 5 2 3 8 8 8 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EMC83534.1 - 0.055 14.0 0.9 2.6 8.7 0.1 3.8 4 0 0 4 4 4 0 HEAT-like repeat LLC1 PF14945.6 EMC83535.1 - 9.7e-45 152.0 0.7 1.1e-44 151.9 0.7 1.0 1 0 0 1 1 1 1 Normal lung function maintenance, Low in Lung Cancer 1 protein PEPCK_GTP PF00821.18 EMC83536.1 - 1.7e-169 563.4 0.4 2.1e-169 563.0 0.4 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain PEPCK_N PF17297.2 EMC83536.1 - 2.2e-98 328.2 0.0 2.9e-98 327.8 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase N-terminal domain zf-H2C2_2 PF13465.6 EMC83537.1 - 2.2e-31 106.9 62.3 7.4e-06 26.2 2.2 7.5 7 0 0 7 7 7 7 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC83537.1 - 1.6e-16 59.6 68.4 0.0048 17.6 0.7 9.2 9 0 0 9 9 9 7 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC83537.1 - 1.1e-15 57.1 69.8 0.00023 21.4 2.1 9.2 9 0 0 9 9 9 6 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 EMC83537.1 - 1.6e-09 37.4 71.4 0.0019 17.9 1.5 8.9 9 1 0 9 9 9 7 C2H2-type zinc-finger domain GAGA PF09237.11 EMC83537.1 - 0.00065 19.4 14.5 0.0075 16.0 0.0 5.1 1 1 5 6 6 6 1 GAGA factor AKAP95 PF04988.12 EMC83537.1 - 0.0018 18.5 1.1 0.0018 18.5 1.1 4.0 3 1 2 5 5 5 1 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_jaz PF12171.8 EMC83537.1 - 0.0037 17.5 43.1 0.75 10.1 0.8 8.1 8 0 0 8 8 7 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC83537.1 - 0.013 15.9 0.4 0.013 15.9 0.4 7.6 9 0 0 9 9 7 0 Zinc-finger of C2H2 type zf-RING_7 PF02591.15 EMC83537.1 - 0.015 15.5 0.4 7.5 6.8 0.1 3.1 2 0 0 2 2 2 0 C4-type zinc ribbon domain zf-C2H2_6 PF13912.6 EMC83537.1 - 0.027 14.5 0.3 0.027 14.5 0.3 9.5 10 2 0 10 10 10 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EMC83537.1 - 0.053 13.3 0.5 0.053 13.3 0.5 6.2 7 0 0 7 7 7 0 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 EMC83537.1 - 0.087 13.0 0.4 0.087 13.0 0.4 5.1 3 2 3 6 6 6 0 Zinc ribbon domain zinc_ribbon_15 PF17032.5 EMC83537.1 - 0.71 10.7 30.4 0.73 10.6 2.4 4.3 2 1 1 4 4 4 0 zinc-ribbon family RNA_POL_M_15KD PF02150.16 EMC83537.1 - 0.88 9.5 21.8 1.2 9.0 0.4 6.0 6 0 0 6 6 6 0 RNA polymerases M/15 Kd subunit RRM_1 PF00076.22 EMC83538.1 - 0.00017 21.4 0.0 0.00053 19.7 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 EMC83539.1 - 1.1e-10 41.9 17.4 0.02 15.8 0.2 5.8 5 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC83539.1 - 0.00071 19.8 0.0 0.97 9.8 0.2 3.6 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMC83539.1 - 0.0097 14.6 0.4 0.92 8.1 0.1 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 TP6A_N PF04406.14 EMC83540.1 - 1.5e-23 82.6 0.2 2.8e-23 81.7 0.2 1.5 1 0 0 1 1 1 1 Type IIB DNA topoisomerase DUF760 PF05542.11 EMC83540.1 - 0.089 13.2 0.1 3 8.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF760) TGFb_propeptide PF00688.18 EMC83541.1 - 5.2e-68 229.4 0.0 8.4e-68 228.8 0.0 1.3 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 EMC83541.1 - 2e-37 128.3 0.9 6e-37 126.8 0.7 1.9 2 0 0 2 2 2 1 Transforming growth factor beta like domain DUF3504 PF12012.8 EMC83541.1 - 0.088 12.7 0.1 3.4 7.6 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3504) Rtf2 PF04641.12 EMC83542.1 - 9.4e-84 280.9 11.3 1.1e-83 280.6 11.3 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger Mitofilin PF09731.9 EMC83542.1 - 0.023 13.6 4.0 0.026 13.4 4.0 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein zf-NOSIP PF15906.5 EMC83542.1 - 0.041 14.0 1.1 0.14 12.3 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger of nitric oxide synthase-interacting protein Branch PF02485.21 EMC83543.1 - 5.7e-53 180.0 1.4 1.5e-52 178.6 0.2 1.9 2 0 0 2 2 2 1 Core-2/I-Branching enzyme Serine_rich PF08824.10 EMC83544.1 - 5.4e-62 208.4 1.3 5.4e-62 208.4 1.3 1.6 2 0 0 2 2 2 1 Serine rich protein interaction domain CAS_C PF12026.8 EMC83544.1 - 4.7e-57 193.4 5.7 4.7e-57 193.4 5.7 2.2 2 0 0 2 2 2 1 Crk-Associated Substrate C-terminal domain SH3_9 PF14604.6 EMC83544.1 - 4.9e-12 45.5 0.0 8.9e-12 44.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC83544.1 - 7.5e-11 41.5 0.0 1.4e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC83544.1 - 5.2e-09 35.6 0.0 1.2e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain DUF3445 PF11927.8 EMC83544.1 - 0.0074 16.0 0.1 0.017 14.8 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF3445) WD40 PF00400.32 EMC83545.1 - 3.6e-33 113.1 1.8 2.1e-06 28.3 0.0 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat CSTF1_dimer PF16699.5 EMC83545.1 - 8.7e-23 79.8 0.3 1.5e-22 79.1 0.3 1.4 1 0 0 1 1 1 1 Cleavage stimulation factor subunit 1, dimerisation domain ANAPC4_WD40 PF12894.7 EMC83545.1 - 2.9e-12 46.7 0.0 0.017 15.4 0.0 4.7 2 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 EMC83545.1 - 6.5e-06 24.7 0.1 0.00012 20.6 0.0 2.2 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Ge1_WD40 PF16529.5 EMC83545.1 - 0.0017 17.4 1.0 0.6 9.0 0.2 2.9 1 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Pkinase PF00069.25 EMC83546.1 - 4.6e-70 236.0 0.0 6.3e-70 235.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC83546.1 - 1.5e-41 142.4 0.0 2.2e-41 141.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC83546.1 - 2.5e-05 23.7 0.0 0.00014 21.3 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EMC83546.1 - 0.0094 14.8 0.8 0.017 13.9 0.8 1.4 1 1 0 1 1 1 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 EMC83546.1 - 0.012 15.1 0.4 0.029 13.9 0.0 1.7 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL FTA2 PF13095.6 EMC83546.1 - 0.027 14.1 0.1 1.2 8.7 0.0 2.3 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Seadorna_VP7 PF07387.11 EMC83546.1 - 0.032 13.3 0.0 0.047 12.7 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 EMC83546.1 - 0.074 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CENP-U PF13097.6 EMC83546.1 - 1.6 8.7 8.0 3.4 7.6 8.0 1.5 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit DUF1279 PF06916.13 EMC83547.1 - 1.5e-28 99.2 1.2 1.8e-28 98.9 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) DUF2583 PF10762.9 EMC83547.1 - 0.16 12.4 0.7 0.25 11.8 0.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2583) 7tm_1 PF00001.21 EMC83548.1 - 1.7e-36 126.0 38.6 5e-35 121.1 38.6 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC83548.1 - 6.4e-08 32.7 29.6 2.7e-07 30.6 25.4 2.7 1 1 2 3 3 3 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 EMC83548.1 - 6.2e-06 25.8 38.5 1.4e-05 24.7 38.5 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC83548.1 - 0.00043 20.0 28.3 0.00043 20.0 28.3 2.9 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx C1q PF00386.21 EMC83550.1 - 1.3e-09 38.3 0.0 1.4e-09 38.2 0.0 1.0 1 0 0 1 1 1 1 C1q domain IRS PF02174.17 EMC83551.1 - 2.5e-29 101.1 0.0 5.6e-29 100.0 0.0 1.6 2 0 0 2 2 2 1 PTB domain (IRS-1 type) Prefoldin_2 PF01920.20 EMC83552.1 - 4.6e-25 87.6 8.5 5.6e-25 87.3 8.5 1.1 1 0 0 1 1 1 1 Prefoldin subunit NPV_P10 PF05531.12 EMC83552.1 - 0.00056 20.3 6.2 0.0092 16.4 0.9 2.2 1 1 0 2 2 2 1 Nucleopolyhedrovirus P10 protein DUF5082 PF16888.5 EMC83552.1 - 0.00064 20.0 11.7 0.0027 18.0 11.7 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF5082) Prefoldin PF02996.17 EMC83552.1 - 0.0029 17.5 8.4 0.08 12.9 8.4 2.1 1 1 0 1 1 1 1 Prefoldin subunit KxDL PF10241.9 EMC83552.1 - 0.0073 16.6 5.1 0.085 13.1 0.5 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein UPF0054 PF02130.17 EMC83552.1 - 0.01 15.6 2.6 0.028 14.2 2.6 1.7 1 1 0 1 1 1 0 Uncharacterized protein family UPF0054 FlxA PF14282.6 EMC83552.1 - 0.01 15.8 6.9 0.46 10.5 0.3 2.3 2 0 0 2 2 2 0 FlxA-like protein FliD_C PF07195.12 EMC83552.1 - 0.011 15.2 3.3 0.032 13.7 0.1 2.0 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Cep57_CLD_2 PF14197.6 EMC83552.1 - 0.012 15.7 8.3 0.5 10.5 0.9 2.3 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 DUF5320 PF17253.2 EMC83552.1 - 0.012 16.7 3.6 0.055 14.5 0.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5320) Helo_like_N PF17111.5 EMC83552.1 - 0.014 14.8 5.3 0.81 9.0 0.3 2.1 1 1 1 2 2 2 0 Fungal N-terminal domain of STAND proteins DUF4618 PF15397.6 EMC83552.1 - 0.019 14.4 6.1 0.21 11.0 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) RraB PF06877.11 EMC83552.1 - 0.02 15.6 2.2 0.27 12.0 0.1 2.3 1 1 1 2 2 2 0 Regulator of ribonuclease activity B ABC_tran_CTD PF16326.5 EMC83552.1 - 0.022 15.0 7.0 0.42 10.9 1.0 2.5 2 0 0 2 2 2 0 ABC transporter C-terminal domain DUF4854 PF16146.5 EMC83552.1 - 0.023 15.0 2.5 0.032 14.6 2.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4854) Fib_alpha PF08702.10 EMC83552.1 - 0.025 14.8 6.8 0.91 9.7 1.3 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family TPR_MLP1_2 PF07926.12 EMC83552.1 - 0.028 14.5 10.7 0.26 11.4 3.1 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF2721 PF11026.8 EMC83552.1 - 0.032 14.1 0.8 2.7 7.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Atg14 PF10186.9 EMC83552.1 - 0.034 13.3 0.4 0.059 12.4 0.4 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 BLI1 PF17324.2 EMC83552.1 - 0.039 14.6 6.5 0.33 11.6 1.1 2.2 2 0 0 2 2 2 0 BLOC-1 interactor 1 DUF4140 PF13600.6 EMC83552.1 - 0.048 14.1 4.2 4.5 7.8 1.0 2.1 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DivIC PF04977.15 EMC83552.1 - 0.053 13.3 4.9 2.6 7.9 0.3 2.3 2 0 0 2 2 2 0 Septum formation initiator Rx_N PF18052.1 EMC83552.1 - 0.064 13.5 5.0 0.23 11.7 0.7 2.2 2 0 0 2 2 2 0 Rx N-terminal domain FlaC_arch PF05377.11 EMC83552.1 - 0.094 13.1 8.6 1.5 9.2 1.2 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 EMC83552.1 - 0.098 12.7 5.9 0.21 11.6 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Fzo_mitofusin PF04799.13 EMC83552.1 - 0.12 12.0 4.3 0.97 9.0 0.3 2.1 2 0 0 2 2 2 0 fzo-like conserved region CdvA PF18822.1 EMC83552.1 - 0.16 11.8 8.7 0.19 11.5 2.0 2.2 2 0 0 2 2 2 0 CdvA-like coiled-coil domain YabA PF06156.13 EMC83552.1 - 0.21 12.2 6.7 0.36 11.5 0.5 2.3 1 1 1 2 2 2 0 Initiation control protein YabA DASH_Spc34 PF08657.10 EMC83552.1 - 0.22 11.3 6.5 1.6 8.5 5.5 2.0 1 1 1 2 2 2 0 DASH complex subunit Spc34 UPF0242 PF06785.11 EMC83552.1 - 0.22 11.6 10.5 0.45 10.6 10.5 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus CCDC-167 PF15188.6 EMC83552.1 - 0.24 11.7 7.3 0.81 10.1 2.5 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 TMF_DNA_bd PF12329.8 EMC83552.1 - 0.25 11.4 11.5 2 8.4 1.3 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding APG6_N PF17675.1 EMC83552.1 - 0.47 11.0 11.2 2.4 8.7 2.7 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region BORCS7 PF16088.5 EMC83552.1 - 0.48 10.7 6.6 2.9 8.2 0.2 2.1 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 7 FAM76 PF16046.5 EMC83552.1 - 0.52 9.6 6.6 0.83 8.9 6.6 1.4 1 1 0 1 1 1 0 FAM76 protein UPF0449 PF15136.6 EMC83552.1 - 0.6 10.6 7.5 3.4 8.2 1.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 DUF4407 PF14362.6 EMC83552.1 - 0.76 9.1 5.2 1.4 8.3 5.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Fmp27_WPPW PF10359.9 EMC83552.1 - 0.91 8.3 8.6 0.31 9.8 1.4 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain FAM167 PF11652.8 EMC83552.1 - 0.94 10.0 5.0 0.55 10.8 0.7 2.3 1 1 2 3 3 3 0 FAM167 Plk4_PB2 PF18409.1 EMC83552.1 - 1.1 10.0 5.1 12 6.7 5.1 2.1 1 1 0 1 1 1 0 Polo-like Kinase 4 Polo Box 2 Med4 PF10018.9 EMC83552.1 - 1.1 9.0 8.1 1.3 8.7 0.9 2.1 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Med9 PF07544.13 EMC83552.1 - 1.3 9.2 12.7 1.8 8.7 2.6 3.0 2 2 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 FlgM PF04316.13 EMC83552.1 - 1.5 9.2 5.3 14 6.1 0.5 2.6 2 1 0 2 2 2 0 Anti-sigma-28 factor, FlgM AAA_23 PF13476.6 EMC83552.1 - 2.4 8.6 10.2 3.4 8.1 10.2 1.3 1 1 0 1 1 1 0 AAA domain SlyX PF04102.12 EMC83552.1 - 5.6 7.7 7.9 9.1 7.0 1.0 2.4 2 1 0 2 2 2 0 SlyX p450 PF00067.22 EMC83553.1 - 1.7e-88 297.5 0.1 1.8e-88 297.3 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 zf-C2H2 PF00096.26 EMC83555.1 - 4.1e-19 67.9 56.3 0.00012 22.3 1.0 8.8 9 0 0 9 9 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC83555.1 - 3.2e-18 64.9 56.5 0.00072 20.2 0.9 8.6 8 0 0 8 8 8 6 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC83555.1 - 1.3e-09 38.0 68.1 7.6e-08 32.4 0.4 11.7 13 0 0 13 13 12 5 Zinc-finger double domain zf-C2H2_3rep PF18868.1 EMC83555.1 - 9.2e-06 26.3 21.9 2.9e-05 24.8 1.7 5.9 4 2 1 6 6 6 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 EMC83555.1 - 1.4e-05 25.4 34.0 0.00024 21.4 2.1 6.9 4 2 1 6 6 6 3 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.6 EMC83555.1 - 3.3e-05 23.5 3.1 3.3e-05 23.5 3.1 8.4 8 1 0 8 8 8 2 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.6 EMC83555.1 - 0.01 15.8 1.0 0.01 15.8 1.0 8.0 7 2 0 7 7 7 0 C2H2-type zinc finger CpXC PF14353.6 EMC83555.1 - 0.039 14.0 17.1 2.8 8.0 0.1 5.8 4 1 0 4 4 4 0 CpXC protein zf-C2HC_2 PF13913.6 EMC83555.1 - 0.2 11.6 17.3 0.47 10.4 0.8 5.9 5 1 0 5 5 5 0 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.8 EMC83555.1 - 0.2 12.0 29.4 0.57 10.5 0.9 6.2 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding Actin_micro PF17003.5 EMC83555.1 - 0.37 9.9 15.6 2.2 7.4 0.5 3.9 3 1 0 3 3 3 0 Putative actin-like family zf_C2H2_ZHX PF18387.1 EMC83555.1 - 0.39 10.4 14.8 3.3 7.4 0.1 5.4 5 0 0 5 5 5 0 Zinc-fingers and homeoboxes C2H2 finger domain PyrI_C PF02748.15 EMC83555.1 - 1.2 9.1 18.5 8.9 6.3 0.3 5.6 4 1 1 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain C1_1 PF00130.22 EMC83555.1 - 2.5 8.1 21.9 0.99 9.3 0.8 4.8 5 1 1 6 6 5 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF3268 PF11672.8 EMC83555.1 - 4.2 7.7 10.1 22 5.4 3.3 3.0 2 0 0 2 2 2 0 zinc-finger-containing domain GAGA PF09237.11 EMC83555.1 - 6.4 6.7 8.1 1.2 9.0 0.1 3.1 3 0 0 3 3 3 0 GAGA factor zf-C2H2_4 PF13894.6 EMC83556.1 - 9.1e-10 38.5 28.7 0.049 14.5 0.1 6.1 6 0 0 6 6 5 4 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EMC83556.1 - 2.1e-09 37.7 26.9 0.005 17.1 0.3 4.6 3 1 1 4 4 4 4 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 EMC83556.1 - 0.00016 22.3 19.3 0.18 12.5 0.8 5.0 3 2 1 4 4 4 3 Zinc finger C2H2-type, 3 repeats zf-C2H2 PF00096.26 EMC83556.1 - 0.00033 21.0 34.3 0.37 11.3 0.8 6.1 6 0 0 6 6 6 3 Zinc finger, C2H2 type zf-met PF12874.7 EMC83556.1 - 0.0022 18.3 12.1 0.11 13.0 0.4 3.1 3 0 0 3 3 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMC83556.1 - 0.02 15.2 15.5 0.035 14.4 0.2 3.8 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMC83556.1 - 0.058 13.4 24.7 0.45 10.6 0.2 4.9 4 0 0 4 4 4 0 C2H2-type zinc finger Zn_Tnp_IS1 PF03811.13 EMC83556.1 - 0.52 10.1 3.5 9 6.1 0.9 2.9 2 0 0 2 2 2 0 InsA N-terminal domain PhnA_Zn_Ribbon PF08274.12 EMC83556.1 - 1.2 9.2 3.7 3.6 7.6 0.0 2.9 3 0 0 3 3 3 0 PhnA Zinc-Ribbon zf-H2C2_2 PF13465.6 EMC83556.1 - 3.5 8.2 18.8 7.1 7.2 0.3 5.8 5 0 0 5 5 5 0 Zinc-finger double domain zf-CpG_bind_C PF12269.8 EMC83556.1 - 4 7.2 14.5 0.11 12.3 2.1 3.0 3 0 0 3 3 3 0 CpG binding protein zinc finger C terminal domain zf-C2H2_12 PF18658.1 EMC83556.1 - 5.6 6.6 11.0 5.4 6.7 0.0 3.8 4 0 0 4 4 4 0 Zinc-finger C2H2-type DUF3502 PF12010.8 EMC83557.1 - 0.043 14.4 0.1 0.11 13.2 0.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3502) PhoLip_ATPase_C PF16212.5 EMC83558.1 - 1.8e-51 175.3 24.4 1.8e-51 175.3 24.4 2.6 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EMC83558.1 - 3.9e-17 61.7 3.3 1e-16 60.3 3.3 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EMC83558.1 - 3e-14 53.8 2.7 3.5e-11 43.8 2.7 3.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EMC83558.1 - 3.1e-10 39.9 0.0 3.1e-10 39.9 0.0 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 EMC83558.1 - 2.2e-08 34.0 0.0 2.9e-07 30.5 0.0 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EMC83558.1 - 0.0068 16.2 0.0 0.03 14.1 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase GNVR PF13807.6 EMC83558.1 - 0.043 13.7 0.1 0.16 11.9 0.1 2.0 1 0 0 1 1 1 0 G-rich domain on putative tyrosine kinase DUF4174 PF13778.6 EMC83558.1 - 0.19 12.2 0.1 0.49 10.9 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) Ion_trans PF00520.31 EMC83559.1 - 3.7e-37 127.9 9.3 5.4e-37 127.3 9.3 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 EMC83559.1 - 1.4e-26 92.6 0.0 3.5e-26 91.4 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 EMC83559.1 - 5.5e-14 51.9 3.0 5.5e-14 51.9 3.0 2.0 2 0 0 2 2 2 1 Ion channel PAH PF02671.21 EMC83559.1 - 0.17 12.1 0.9 0.54 10.5 0.1 2.2 2 0 0 2 2 2 0 Paired amphipathic helix repeat Glycos_transf_2 PF00535.26 EMC83560.1 - 3.1e-33 115.0 0.0 3.7e-33 114.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EMC83560.1 - 1.1e-09 38.5 0.0 2.5e-09 37.4 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EMC83560.1 - 4.6e-05 23.0 0.0 8.4e-05 22.1 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 EMC83560.1 - 0.00039 20.0 0.0 0.00059 19.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 EMC83560.1 - 0.13 12.8 0.0 0.3 11.6 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 Homeodomain PF00046.29 EMC83561.1 - 2.2e-07 30.6 0.5 5.1e-07 29.5 0.5 1.6 1 0 0 1 1 1 1 Homeodomain zf-C2H2_4 PF13894.6 EMC83561.1 - 0.00054 20.6 53.3 0.011 16.5 0.3 9.4 9 0 0 9 9 9 3 C2H2-type zinc finger Homeobox_KN PF05920.11 EMC83561.1 - 0.078 12.9 0.3 0.27 11.2 0.3 1.9 1 0 0 1 1 1 0 Homeobox KN domain zf-Di19 PF05605.12 EMC83561.1 - 0.087 13.1 0.2 0.087 13.1 0.2 7.5 7 2 1 8 8 8 0 Drought induced 19 protein (Di19), zinc-binding Thioredoxin_3 PF13192.6 EMC83561.1 - 0.21 11.6 2.8 8.3 6.5 0.0 4.6 5 0 0 5 5 5 0 Thioredoxin domain zf_C2H2_ZHX PF18387.1 EMC83561.1 - 0.4 10.4 0.0 0.4 10.4 0.0 5.4 5 1 1 6 6 6 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_9 PF16293.5 EMC83561.1 - 2.4 8.1 12.1 0.13 12.1 0.2 4.4 5 0 0 5 5 5 0 C2H2 type zinc-finger (1 copy) zf-C2H2_3rep PF18868.1 EMC83561.1 - 4.1 8.1 17.5 7.5 7.2 0.1 5.1 5 0 0 5 5 5 0 Zinc finger C2H2-type, 3 repeats PB1 PF00564.24 EMC83562.1 - 1.1e-13 50.9 0.0 1.9e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 PB1 domain PDZ PF00595.24 EMC83562.1 - 3.3e-11 43.4 0.0 6.1e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC83562.1 - 2.7e-08 33.5 0.1 5.4e-08 32.6 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PL48 PF15903.5 EMC83563.1 - 3.3e-178 591.9 1.4 5.1e-178 591.3 0.1 2.0 2 0 0 2 2 2 1 Filopodia upregulated, FAM65 HEAT_2 PF13646.6 EMC83563.1 - 0.001 19.4 3.0 0.0038 17.6 3.0 2.0 1 0 0 1 1 1 1 HEAT repeats DUF1805 PF08827.11 EMC83563.1 - 0.0025 18.1 0.3 0.037 14.3 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1805) LIDHydrolase PF10230.9 EMC83563.1 - 0.11 12.0 0.3 2.5 7.6 0.0 2.3 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase HR1 PF02185.16 EMC83563.1 - 0.22 11.7 2.1 0.89 9.7 0.0 3.3 3 0 0 3 3 3 0 Hr1 repeat eIF-5_eIF-2B PF01873.17 EMC83565.1 - 1.4e-41 141.0 0.2 2.5e-41 140.2 0.2 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Cytochrom_c3_2 PF14537.6 EMC83565.1 - 1.8 9.1 6.8 0.13 12.7 1.0 2.1 2 1 0 2 2 2 0 Cytochrome c3 7tm_4 PF13853.6 EMC83566.1 - 1.2e-18 67.9 0.7 1.4e-18 67.6 0.7 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC83566.1 - 0.048 13.0 0.6 0.064 12.6 0.6 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Trypsin PF00089.26 EMC83567.1 - 2.7e-17 63.3 3.1 2.9e-17 63.2 3.1 1.0 1 0 0 1 1 1 1 Trypsin Bac_surface_Ag PF01103.23 EMC83568.1 - 1.1e-63 215.7 2.9 1.3e-63 215.4 2.9 1.0 1 0 0 1 1 1 1 Surface antigen POTRA PF07244.15 EMC83568.1 - 0.063 13.9 0.0 0.1 13.2 0.0 1.3 1 0 0 1 1 1 0 Surface antigen variable number repeat CH PF00307.31 EMC83569.1 - 3.2e-34 117.4 4.9 1.2e-17 64.1 1.2 2.2 2 0 0 2 2 2 2 Calponin homology (CH) domain CH_2 PF06294.11 EMC83569.1 - 3.3e-05 23.9 0.4 0.016 15.3 0.0 2.2 2 0 0 2 2 2 2 CH-like domain in sperm protein CAMSAP_CH PF11971.8 EMC83569.1 - 7.9e-05 22.4 0.1 0.054 13.3 0.0 2.6 2 0 0 2 2 2 2 CAMSAP CH domain ACT PF01842.25 EMC83569.1 - 0.12 12.2 0.0 0.4 10.5 0.0 1.9 1 0 0 1 1 1 0 ACT domain CH PF00307.31 EMC83570.1 - 1.6e-31 108.7 4.3 2.1e-15 56.8 0.1 2.3 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EMC83570.1 - 1.7e-05 24.5 0.2 0.022 14.6 0.0 2.5 2 0 0 2 2 2 2 CAMSAP CH domain Shisa PF13908.6 EMC83571.1 - 3.6e-07 30.6 5.7 3.6e-07 30.6 5.7 2.1 2 0 0 2 2 2 2 Wnt and FGF inhibitory regulator Pentapeptide_4 PF13599.6 EMC83572.1 - 2.1 8.5 13.9 9.7 6.4 3.2 2.7 1 1 0 2 2 2 0 Pentapeptide repeats (9 copies) DUF2773 PF10971.8 EMC83572.1 - 8.3 6.6 8.5 1e+02 3.2 0.3 4.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2773) Acyl_transf_1 PF00698.21 EMC83573.1 - 1.5e-113 379.5 0.0 2.5e-113 378.8 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain ketoacyl-synt PF00109.26 EMC83573.1 - 1.2e-73 247.8 0.0 2.1e-73 247.0 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thioesterase PF00975.20 EMC83573.1 - 1.4e-63 215.1 0.1 4.4e-62 210.2 0.1 2.6 2 0 0 2 2 2 1 Thioesterase domain KR PF08659.10 EMC83573.1 - 1.9e-47 161.5 0.0 1.5e-46 158.6 0.0 2.6 3 0 0 3 3 3 1 KR domain Ketoacyl-synt_C PF02801.22 EMC83573.1 - 3.6e-38 130.2 0.0 7.6e-38 129.2 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EMC83573.1 - 5.1e-36 123.5 0.0 1.2e-35 122.4 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 EMC83573.1 - 4.7e-18 65.4 0.1 2.1e-17 63.3 0.0 2.3 2 0 0 2 2 1 1 Zinc-binding dehydrogenase PS-DH PF14765.6 EMC83573.1 - 8.5e-18 64.6 0.0 1.9e-17 63.5 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase ADH_zinc_N_2 PF13602.6 EMC83573.1 - 4.7e-15 56.8 0.1 5.1e-14 53.5 0.0 2.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase PP-binding PF00550.25 EMC83573.1 - 5.2e-09 36.3 0.5 1.3e-08 35.1 0.5 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.25 EMC83573.1 - 4.6e-07 29.5 0.0 6.2e-05 22.5 0.0 3.1 3 0 0 3 3 3 1 short chain dehydrogenase Thiolase_N PF00108.23 EMC83573.1 - 5.3e-05 22.7 0.1 0.00012 21.5 0.1 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain YjeF_N PF03853.15 EMC83573.1 - 0.0048 16.8 0.1 2.5 8.0 0.0 3.7 4 0 0 4 4 4 1 YjeF-related protein N-terminus ACP_syn_III PF08545.10 EMC83573.1 - 0.013 15.3 0.1 0.058 13.3 0.1 2.1 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III AlaDh_PNT_C PF01262.21 EMC83573.1 - 0.14 11.4 0.1 0.29 10.4 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Methyltransf_23 PF13489.6 EMC83573.1 - 0.16 11.8 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EMC83573.1 - 0.16 12.7 0.0 0.5 11.2 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase domain MFS_1 PF07690.16 EMC83574.1 - 1.6e-35 122.7 46.9 9.1e-34 116.9 30.1 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily TraB PF01963.17 EMC83577.1 - 6.6e-23 81.9 0.0 7.2e-23 81.8 0.0 1.0 1 0 0 1 1 1 1 TraB family Neur_chan_LBD PF02931.23 EMC83578.1 - 2.6e-71 239.5 2.6 3.4e-71 239.1 2.6 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC83578.1 - 4.1e-63 213.6 0.5 5.1e-63 213.3 0.5 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region SUR7 PF06687.12 EMC83578.1 - 0.0065 16.1 0.0 0.036 13.7 0.0 2.2 1 1 0 1 1 1 1 SUR7/PalI family Frag1 PF10277.9 EMC83578.1 - 0.045 13.3 2.4 0.94 9.0 0.5 2.3 2 0 0 2 2 2 0 Frag1/DRAM/Sfk1 family TcpE PF12648.7 EMC83578.1 - 5.6 7.6 6.2 2.4 8.8 1.8 2.3 2 0 0 2 2 2 0 TcpE family DUF3713 PF12506.8 EMC83579.1 - 0.21 11.9 1.2 0.39 11.0 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3713) MFS_1 PF07690.16 EMC83580.1 - 3.2e-28 98.7 46.5 6.7e-26 91.0 28.4 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily RAWUL PF16207.5 EMC83581.1 - 4e-16 59.5 0.8 1.1e-15 58.0 0.3 2.0 2 1 0 2 2 2 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_2 PF13923.6 EMC83581.1 - 8.3e-12 44.8 8.1 2.1e-11 43.4 8.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC83581.1 - 4.1e-09 36.2 9.3 4.1e-09 36.2 9.3 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC83581.1 - 1.1e-07 32.1 8.0 1.1e-07 32.1 8.0 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 EMC83581.1 - 3e-06 27.0 8.4 3e-06 27.0 8.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC83581.1 - 2.8e-05 24.0 9.5 2.8e-05 24.0 9.5 2.5 2 1 1 3 3 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EMC83581.1 - 4.6e-05 23.4 5.5 4.6e-05 23.4 5.5 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 EMC83581.1 - 6.6e-05 23.1 4.9 6.6e-05 23.1 4.9 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EMC83581.1 - 0.00061 19.9 8.6 0.00061 19.9 8.6 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EMC83581.1 - 0.011 15.5 9.4 0.014 15.1 6.3 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-Nse PF11789.8 EMC83581.1 - 0.022 14.6 3.3 0.039 13.8 3.3 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 EMC83581.1 - 0.03 14.2 9.9 0.03 14.2 9.9 2.8 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 DUF3337 PF11816.8 EMC83581.1 - 0.03 14.2 5.3 0.99 9.2 5.3 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3337) GAGA PF09237.11 EMC83581.1 - 0.032 14.0 0.1 0.1 12.4 0.1 1.8 1 0 0 1 1 1 0 GAGA factor zf-RING_10 PF16685.5 EMC83581.1 - 0.18 12.0 10.3 0.095 12.9 5.9 2.4 2 0 0 2 2 2 0 zinc RING finger of MSL2 DZR PF12773.7 EMC83581.1 - 0.85 9.7 9.8 0.96 9.5 5.8 2.4 2 0 0 2 2 2 0 Double zinc ribbon DUF1272 PF06906.11 EMC83581.1 - 1.2 9.3 9.5 0.79 9.9 6.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) Synaphin PF05835.12 EMC83582.1 - 2.3e-23 83.0 9.3 1.5e-22 80.4 9.3 1.8 1 1 0 1 1 1 1 Synaphin protein PET117 PF15786.5 EMC83582.1 - 5.1 7.4 7.3 0.7 10.2 2.4 2.0 1 1 1 2 2 2 0 PET assembly of cytochrome c oxidase, mitochondrial adh_short_C2 PF13561.6 EMC83583.1 - 0.14 11.7 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Pkinase PF00069.25 EMC83584.1 - 1e-38 133.2 0.0 2.4e-38 132.0 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC83584.1 - 1.2e-26 93.6 0.3 6.7e-21 74.7 1.5 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EMC83584.1 - 0.0082 16.1 0.1 0.24 11.3 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EMC83584.1 - 0.026 13.8 0.2 0.071 12.4 0.1 1.6 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.14 EMC83584.1 - 0.098 12.0 0.3 0.13 11.6 0.3 1.3 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Enolase_C PF00113.22 EMC83586.1 - 9.7e-27 94.0 0.1 1.1e-26 93.8 0.1 1.0 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Hormone_recep PF00104.30 EMC83588.1 - 1.8e-30 106.1 6.5 2.6e-30 105.6 6.5 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 EMC83588.1 - 5.5e-29 100.4 13.0 9.2e-29 99.7 13.0 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hamartin PF04388.12 EMC83589.1 - 0.2 10.3 16.6 0.31 9.7 16.6 1.3 1 0 0 1 1 1 0 Hamartin protein Pkinase PF00069.25 EMC83590.1 - 1.3e-72 244.4 0.0 1.9e-72 243.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DCX PF03607.17 EMC83590.1 - 1e-42 144.0 0.2 3.8e-22 78.1 0.0 2.6 2 0 0 2 2 2 2 Doublecortin Pkinase_Tyr PF07714.17 EMC83590.1 - 5.9e-32 111.0 0.0 9.1e-32 110.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC83590.1 - 0.0034 16.8 0.0 0.01 15.2 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EMC83590.1 - 0.028 13.8 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Mab-21 PF03281.14 EMC83591.1 - 5.3e-100 334.5 0.0 6.4e-100 334.2 0.0 1.1 1 0 0 1 1 1 1 Mab-21 protein PP2C PF00481.21 EMC83592.1 - 1e-55 189.1 0.3 1.4e-55 188.8 0.3 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EMC83592.1 - 2.7e-13 50.0 0.1 9.3e-13 48.3 0.1 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EMC83592.1 - 0.069 13.1 0.3 6 6.7 0.1 2.2 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) Beach PF02138.18 EMC83593.1 - 1.8e-126 421.1 0.1 3e-126 420.4 0.1 1.3 1 0 0 1 1 1 1 Beige/BEACH domain FYVE PF01363.21 EMC83593.1 - 5.4e-18 64.9 12.4 1.3e-17 63.7 12.4 1.7 1 0 0 1 1 1 1 FYVE zinc finger PH_BEACH PF14844.6 EMC83593.1 - 1.8e-12 47.2 0.0 5.5e-12 45.7 0.0 1.8 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH DUF4704 PF15787.5 EMC83593.1 - 2e-06 27.2 4.6 3.8e-06 26.3 0.9 3.2 2 2 2 4 4 4 2 Domain of unknown function (DUF4704) WD40 PF00400.32 EMC83593.1 - 4.3e-06 27.4 10.6 0.0038 18.0 0.2 5.1 5 0 0 5 5 5 2 WD domain, G-beta repeat Laminin_G_3 PF13385.6 EMC83593.1 - 0.0015 18.7 0.0 0.0047 17.1 0.0 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF4800 PF16057.5 EMC83593.1 - 0.0056 16.0 1.4 0.013 14.8 1.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4800) E3_UbLigase_R4 PF13764.6 EMC83593.1 - 0.043 12.0 0.1 0.095 10.8 0.1 1.5 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase UBR4 CTP_transf_1 PF01148.20 EMC83594.1 - 2.2e-85 286.7 20.4 2.7e-85 286.4 20.4 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family Homeodomain PF00046.29 EMC83595.1 - 3e-22 78.2 1.3 4.7e-22 77.6 1.3 1.3 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 EMC83595.1 - 0.03 13.8 0.0 0.05 13.1 0.0 1.3 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.11 EMC83595.1 - 0.041 13.8 0.0 0.089 12.7 0.0 1.6 1 0 0 1 1 1 0 Homeobox KN domain PHC2_SAM_assoc PF16616.5 EMC83595.1 - 0.068 14.0 0.6 0.093 13.6 0.6 1.3 1 0 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 Sulfotransfer_1 PF00685.27 EMC83596.1 - 4.6e-11 42.7 0.1 1.8e-09 37.5 0.1 3.5 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC83596.1 - 2e-06 28.4 0.0 0.00053 20.4 0.0 3.4 2 1 0 2 2 2 1 Sulfotransferase family DUF4962 PF16332.5 EMC83596.1 - 5.8e-06 25.1 4.1 1.1e-05 24.2 4.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4962) DUF1195 PF06708.11 EMC83596.1 - 1.1 9.0 3.8 2.6 7.8 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1195) RVT_1 PF00078.27 EMC83597.1 - 0.076 12.5 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Cadherin PF00028.17 EMC83598.1 - 6.1e-80 263.8 9.6 9.3e-17 61.3 0.0 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 EMC83598.1 - 1.9e-52 177.5 4.5 2.8e-52 176.9 1.0 2.4 2 0 0 2 2 2 1 Cadherin cytoplasmic region Cadherin_2 PF08266.12 EMC83598.1 - 1.3e-07 31.3 0.0 1 9.2 0.0 4.4 4 1 0 4 4 4 3 Cadherin-like Cadherin_3 PF16184.5 EMC83598.1 - 6.5e-06 26.1 6.9 1.4 8.9 0.0 5.1 6 0 0 6 6 6 3 Cadherin-like Cadherin_4 PF17803.1 EMC83598.1 - 0.0023 18.5 18.3 0.013 16.1 1.5 5.1 6 0 0 6 6 6 2 Bacterial cadherin-like domain Big_9 PF17963.1 EMC83598.1 - 0.015 16.0 15.2 1.9 9.3 0.1 5.3 6 0 0 6 6 6 0 Bacterial Ig domain Podovirus_Gp16 PF05894.12 EMC83598.1 - 0.063 12.7 0.6 0.31 10.5 0.0 2.2 2 0 0 2 2 2 0 Podovirus DNA encapsidation protein (Gp16) DUF2663 PF10864.8 EMC83598.1 - 0.073 13.5 0.3 16 5.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2663) DUF4199 PF13858.6 EMC83598.1 - 0.12 12.7 0.2 0.38 11.1 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) Invasin_D3 PF09134.10 EMC83598.1 - 0.25 11.7 9.4 1.8 8.9 0.1 4.7 6 0 0 6 6 6 0 Invasin, domain 3 Cadherin PF00028.17 EMC83599.1 - 1e-85 282.3 8.2 7.6e-20 71.2 0.1 5.2 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 EMC83599.1 - 7.5e-56 188.5 0.1 1.4e-55 187.6 0.1 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_2 PF08266.12 EMC83599.1 - 2.9e-06 27.0 0.0 0.96 9.3 0.0 4.5 4 1 0 4 4 4 2 Cadherin-like Cadherin_3 PF16184.5 EMC83599.1 - 2.5e-05 24.3 5.3 0.94 9.5 0.1 5.2 5 0 0 5 5 5 2 Cadherin-like RET_CLD1 PF17756.1 EMC83599.1 - 0.1 12.9 0.0 6.5 7.1 0.0 2.8 2 0 0 2 2 2 0 RET Cadherin like domain 1 Cadherin_4 PF17803.1 EMC83599.1 - 0.99 10.1 18.3 3 8.5 0.4 4.6 4 0 0 4 4 4 0 Bacterial cadherin-like domain Invasin_D3 PF09134.10 EMC83599.1 - 2.4 8.5 7.9 24 5.3 0.5 4.4 3 1 0 4 4 4 0 Invasin, domain 3 Patched PF02460.18 EMC83600.1 - 3.5e-66 223.9 11.9 4.5e-66 223.5 11.9 1.0 1 0 0 1 1 1 1 Patched family ACR_tran PF00873.19 EMC83600.1 - 2.9 5.4 8.5 3.5 5.1 8.5 1.3 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Peptidase_M41 PF01434.18 EMC83601.1 - 2.8e-65 219.8 1.7 5.6e-65 218.8 1.7 1.5 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EMC83601.1 - 2.2e-41 141.4 0.0 7.1e-41 139.7 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMC83601.1 - 2.2e-08 33.8 0.0 5.1e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EMC83601.1 - 3.5e-05 24.3 0.0 0.00063 20.2 0.0 2.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EMC83601.1 - 0.00023 21.2 0.0 0.00091 19.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EMC83601.1 - 0.00026 20.3 0.2 0.00088 18.6 0.0 1.9 2 0 0 2 2 2 1 TIP49 P-loop domain RuvB_N PF05496.12 EMC83601.1 - 0.00035 20.4 0.0 0.00079 19.2 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EMC83601.1 - 0.00058 20.1 0.0 0.018 15.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EMC83601.1 - 0.0073 16.1 0.0 0.02 14.6 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 EMC83601.1 - 0.011 15.1 0.3 0.036 13.4 0.3 1.8 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EMC83601.1 - 0.017 15.3 0.0 0.039 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 EMC83601.1 - 0.017 15.2 0.0 0.046 13.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 EMC83601.1 - 0.027 13.6 0.0 0.062 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) FumaraseC_C PF10415.9 EMC83601.1 - 0.028 14.8 3.8 0.22 12.0 1.6 3.4 4 0 0 4 4 3 0 Fumarase C C-terminus AAA_18 PF13238.6 EMC83601.1 - 0.031 14.8 0.1 0.14 12.7 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EMC83601.1 - 0.039 14.4 0.0 0.32 11.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EMC83601.1 - 0.067 12.5 0.0 0.22 10.8 0.0 2.0 1 0 0 1 1 1 0 Zeta toxin AAA_28 PF13521.6 EMC83601.1 - 0.11 12.8 0.2 0.47 10.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EMC83601.1 - 0.11 12.0 0.1 0.42 10.1 0.1 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 EMC83601.1 - 0.15 11.5 0.3 0.54 9.7 0.1 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_25 PF13481.6 EMC83601.1 - 0.18 11.4 0.3 1.1 8.7 0.3 2.0 1 1 1 2 2 2 0 AAA domain LRAT PF04970.13 EMC83602.1 - 0.00011 22.5 0.0 0.00016 22.0 0.0 1.3 1 0 0 1 1 1 1 Lecithin retinol acyltransferase DUF4105 PF13387.6 EMC83602.1 - 0.0043 16.7 0.4 0.2 11.3 0.2 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4105) zf-C3HC4_3 PF13920.6 EMC83603.1 - 3.5e-10 39.6 7.0 8.4e-10 38.4 7.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC83603.1 - 4.7e-09 36.4 10.8 4.7e-09 36.4 10.8 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC83603.1 - 1.1e-08 34.8 8.6 1.1e-08 34.8 8.6 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC83603.1 - 1.7e-08 34.2 8.0 1.7e-08 34.2 8.0 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMC83603.1 - 5.3e-07 29.8 7.5 5.3e-07 29.8 7.5 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EMC83603.1 - 9.3e-06 25.4 9.2 0.00013 21.7 9.6 2.3 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EMC83603.1 - 9.5e-05 22.3 7.7 0.00025 20.9 7.7 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EMC83603.1 - 0.00011 22.2 6.3 0.00031 20.7 6.3 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EMC83603.1 - 0.00076 19.6 4.7 0.0022 18.1 4.7 1.9 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 EMC83603.1 - 0.0049 16.9 6.8 0.0077 16.3 3.9 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger DUF1644 PF07800.12 EMC83603.1 - 0.073 13.1 3.8 1.7 8.7 0.1 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1644) zf-RING_4 PF14570.6 EMC83603.1 - 1.1 9.1 13.4 0.04 13.7 3.0 2.6 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain Ig_3 PF13927.6 EMC83604.1 - 3.5e-71 235.8 1.5 4.3e-12 46.5 0.0 7.2 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.16 EMC83604.1 - 4.3e-68 225.4 0.0 2.4e-12 46.8 0.0 7.0 7 0 0 7 7 6 6 Immunoglobulin I-set domain fn3 PF00041.21 EMC83604.1 - 4e-55 184.1 5.0 2.4e-13 50.2 0.0 5.7 5 0 0 5 5 5 5 Fibronectin type III domain Ig_2 PF13895.6 EMC83604.1 - 3.9e-45 152.1 0.7 8.9e-09 35.6 0.0 6.8 7 0 0 7 7 6 5 Immunoglobulin domain ig PF00047.25 EMC83604.1 - 4.4e-39 132.5 2.8 6.8e-08 32.6 0.1 6.9 7 0 0 7 7 6 6 Immunoglobulin domain Bravo_FIGEY PF13882.6 EMC83604.1 - 1e-29 103.7 3.9 2.3e-29 102.6 3.9 1.6 1 0 0 1 1 1 1 Bravo-like intracellular region V-set PF07686.17 EMC83604.1 - 1.1e-21 77.0 5.1 0.0011 19.1 0.0 9.2 6 4 0 6 6 6 4 Immunoglobulin V-set domain Ig_4 PF16680.5 EMC83604.1 - 7e-10 39.0 0.0 0.73 10.1 0.0 5.7 5 0 0 5 5 5 3 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 EMC83604.1 - 4e-09 35.9 0.0 0.00022 20.7 0.0 4.3 5 0 0 5 5 5 2 Immunoglobulin domain C2-set_2 PF08205.12 EMC83604.1 - 7.8e-08 32.3 1.9 0.64 10.1 0.0 6.4 7 1 1 8 8 7 2 CD80-like C2-set immunoglobulin domain Pur_ac_phosph_N PF16656.5 EMC83604.1 - 9.5e-06 26.1 1.2 3 8.5 0.2 4.9 3 1 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain C2-set PF05790.15 EMC83604.1 - 0.00041 20.5 0.3 12 6.2 0.0 4.1 4 0 0 4 4 4 1 Immunoglobulin C2-set domain Ig_C17orf99 PF17736.1 EMC83604.1 - 0.0052 16.8 0.5 30 4.7 0.0 5.0 6 0 0 6 6 6 0 C17orf99 Ig domain fn3_2 PF16893.5 EMC83604.1 - 0.012 15.8 0.0 0.1 12.7 0.0 2.7 3 0 0 3 3 1 0 Fibronectin type III domain Herpes_gE PF02480.16 EMC83604.1 - 0.13 11.0 0.0 33 3.1 0.0 3.5 3 1 0 4 4 4 0 Alphaherpesvirus glycoprotein E PolyA_pol PF01743.20 EMC83605.1 - 3.5e-33 114.7 0.3 6.1e-33 113.9 0.3 1.4 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EMC83605.1 - 9.9e-12 44.5 0.3 7.7e-11 41.6 0.0 2.3 2 0 0 2 2 2 1 Probable RNA and SrmB- binding site of polymerase A Myb_DNA-bind_2 PF08914.11 EMC83605.1 - 0.028 14.6 0.0 0.077 13.2 0.0 1.7 1 0 0 1 1 1 0 Rap1 Myb domain E1-E2_ATPase PF00122.20 EMC83607.1 - 6.4e-39 133.3 0.5 6.4e-39 133.3 0.5 1.3 2 0 0 2 2 2 1 E1-E2 ATPase Collagen PF01391.18 EMC83608.1 - 0.038 13.7 29.3 0.094 12.5 29.3 1.6 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Carn_acyltransf PF00755.20 EMC83609.1 - 1.7e-199 664.3 0.0 2e-199 664.1 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase CPT_N PF16484.5 EMC83609.1 - 5.6e-28 96.7 0.2 1.2e-27 95.6 0.2 1.6 1 0 0 1 1 1 1 Carnitine O-palmitoyltransferase N-terminus TCR PF03638.15 EMC83611.1 - 1.5e-16 60.4 49.8 2.3e-12 47.0 23.4 2.7 2 0 0 2 2 2 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain MSL2-CXC PF16682.5 EMC83611.1 - 1.3 9.2 45.0 0.37 11.0 11.7 3.3 3 0 0 3 3 3 0 CXC domain of E3 ubiquitin-protein ligase MSL2 GMAP PF06540.11 EMC83612.1 - 1.1e-24 86.3 0.1 1.1e-24 86.3 0.1 1.4 2 0 0 2 2 2 1 Galanin message associated peptide (GMAP) Galanin PF01296.18 EMC83612.1 - 3.1e-16 59.0 1.0 5.1e-16 58.3 1.0 1.3 1 0 0 1 1 1 1 Galanin SAPS PF04499.15 EMC83613.1 - 7e-102 341.7 10.7 3.7e-63 214.0 7.5 3.8 3 2 1 4 4 4 2 SIT4 phosphatase-associated protein D5_N PF08706.11 EMC83613.1 - 0.053 13.8 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 D5 N terminal like Atx10homo_assoc PF09759.9 EMC83613.1 - 0.18 11.9 1.8 1.3 9.1 0.2 3.0 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain Ldl_recept_b PF00058.17 EMC83614.1 - 2.6e-152 495.1 48.0 1.2e-13 51.3 0.0 20.5 20 0 0 20 20 20 20 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 EMC83614.1 - 5.2e-38 129.0 64.7 5.9e-12 45.7 7.6 5.6 5 0 0 5 5 5 4 Coagulation Factor Xa inhibitory site Ldl_recept_a PF00057.18 EMC83614.1 - 3e-31 107.3 49.7 1.4e-11 44.4 10.4 4.3 4 0 0 4 4 4 3 Low-density lipoprotein receptor domain class A DUF5050 PF16472.5 EMC83614.1 - 3.8e-23 82.1 0.0 2.1e-05 23.9 0.0 6.0 4 2 1 6 6 6 6 Domain of unknown function (DUF5050) SGL PF08450.12 EMC83614.1 - 1.1e-19 71.0 22.6 0.012 15.2 0.6 11.7 8 3 2 12 12 12 6 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EMC83614.1 - 2e-08 34.3 0.0 11 6.3 0.0 8.2 8 1 1 9 9 9 1 Arylesterase EGF PF00008.27 EMC83614.1 - 0.00063 20.0 61.7 0.023 15.0 4.2 6.4 6 0 0 6 6 6 4 EGF-like domain NHL PF01436.21 EMC83614.1 - 0.013 15.6 0.1 9.4 6.5 0.0 5.2 5 0 0 5 5 5 0 NHL repeat cEGF PF12662.7 EMC83614.1 - 0.055 13.4 22.3 0.036 14.0 1.5 4.9 4 0 0 4 4 4 0 Complement Clr-like EGF-like Insulin_TMD PF17870.1 EMC83614.1 - 0.12 12.5 0.1 0.27 11.3 0.1 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Trypan_PARP PF05887.11 EMC83615.1 - 0.00097 19.1 2.0 0.0012 18.8 2.0 1.2 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Yae1_N PF09811.9 EMC83615.1 - 0.051 13.3 0.1 0.36 10.6 0.0 2.2 1 1 1 2 2 2 0 Essential protein Yae1, N terminal Exo_endo_phos_2 PF14529.6 EMC83617.1 - 3.1e-08 33.5 0.0 5.3e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase LRR_6 PF13516.6 EMC83618.1 - 1.8e-36 121.1 38.3 3.3e-05 23.6 0.0 11.8 13 0 0 13 13 13 8 Leucine Rich repeat LRR_RI_capping PF18779.1 EMC83618.1 - 5.7e-17 61.1 2.0 2.1e-16 59.2 2.0 2.1 1 0 0 1 1 1 1 Capping Ribonuclease inhibitor Leucine Rich Repeat LRR_4 PF12799.7 EMC83618.1 - 7.8e-13 48.4 36.5 0.0046 17.3 0.4 9.0 5 1 5 10 10 10 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMC83618.1 - 0.025 14.3 24.1 8.2 6.3 0.4 7.9 5 1 3 8 8 8 0 Leucine rich repeat LRR_1 PF00560.33 EMC83618.1 - 0.11 13.1 41.7 5.3 8.0 0.1 11.5 14 0 0 14 14 14 0 Leucine Rich Repeat Ras PF00071.22 EMC83621.1 - 4.4e-58 195.4 0.0 5.1e-58 195.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC83621.1 - 8.5e-22 77.6 0.0 1.2e-21 77.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC83621.1 - 9.1e-10 38.3 0.0 1.1e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC83621.1 - 1.2e-06 28.2 0.1 9.1e-06 25.3 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EMC83621.1 - 8.3e-06 25.8 0.0 0.06 13.2 0.0 2.5 2 1 1 3 3 3 2 RsgA GTPase MMR_HSR1 PF01926.23 EMC83621.1 - 1.6e-05 24.9 0.0 2.4e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EMC83621.1 - 0.0017 17.9 0.0 0.015 14.8 0.0 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.12 EMC83621.1 - 0.017 14.5 0.0 0.019 14.3 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 EMC83621.1 - 0.027 14.3 0.4 0.7 9.6 0.0 2.0 1 1 0 2 2 2 0 Conserved hypothetical ATP binding protein Septin PF00735.18 EMC83621.1 - 0.028 13.7 0.0 0.052 12.8 0.0 1.6 1 1 0 1 1 1 0 Septin G-alpha PF00503.20 EMC83621.1 - 0.038 13.2 0.0 1.6 7.8 0.0 2.0 1 1 1 2 2 2 0 G-protein alpha subunit Ldh_1_N PF00056.23 EMC83621.1 - 0.14 12.3 0.0 0.44 10.6 0.0 1.8 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain AAA_25 PF13481.6 EMC83621.1 - 0.17 11.4 0.0 0.39 10.3 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EMC83621.1 - 0.18 12.1 0.1 1.9 8.7 0.1 2.3 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EMC83621.1 - 0.2 12.1 0.1 0.54 10.6 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain LRR_4 PF12799.7 EMC83622.1 - 6.3e-12 45.5 11.7 3.1e-05 24.2 0.1 4.0 2 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMC83622.1 - 1.9e-08 33.9 21.7 7.4e-05 22.4 1.1 3.1 1 1 2 3 3 3 3 Leucine rich repeat LRR_9 PF14580.6 EMC83622.1 - 2.5e-05 23.8 1.0 0.00012 21.7 0.3 2.0 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 EMC83622.1 - 0.0059 17.0 11.0 8.4 7.4 0.0 6.3 4 1 1 5 5 5 1 Leucine Rich Repeat LRR_6 PF13516.6 EMC83622.1 - 0.011 15.7 17.6 0.2 11.8 0.1 5.4 6 0 0 6 6 6 0 Leucine Rich repeat PHD PF00628.29 EMC83623.1 - 0.029 14.2 0.3 0.045 13.7 0.3 1.3 1 0 0 1 1 1 0 PHD-finger LRR_8 PF13855.6 EMC83624.1 - 2.4e-22 78.5 14.0 8e-13 47.9 3.2 3.5 1 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EMC83624.1 - 7.5e-21 73.9 9.0 2.8e-08 33.9 0.3 3.3 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC83624.1 - 1.2e-09 37.4 16.1 0.7 10.7 0.3 6.2 6 0 0 6 6 6 4 Leucine Rich Repeat LRR_9 PF14580.6 EMC83624.1 - 2.3e-08 33.7 6.0 7.5e-06 25.6 1.6 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_5 PF13306.6 EMC83624.1 - 0.00025 21.0 0.0 0.0009 19.2 0.0 1.7 1 1 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 EMC83624.1 - 0.037 14.1 17.0 36 4.7 0.3 6.1 6 0 0 6 6 6 0 Leucine Rich repeat COR PF16095.5 EMC83625.1 - 0.00011 22.1 0.2 0.00024 21.0 0.2 1.7 1 1 0 1 1 1 1 C-terminal of Roc, COR, domain IRF-3 PF10401.9 EMC83626.1 - 1.1e-47 162.1 0.6 1.3e-47 161.9 0.6 1.0 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IRF PF00605.17 EMC83627.1 - 4.2e-33 113.8 0.0 5.2e-33 113.5 0.0 1.1 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor Mito_carr PF00153.27 EMC83628.1 - 4.8e-63 209.1 2.0 3.5e-23 81.4 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein LRR_8 PF13855.6 EMC83629.1 - 5.6e-24 83.7 57.4 2.5e-09 36.7 8.2 5.5 3 1 4 7 7 7 5 Leucine rich repeat ZU5 PF00791.20 EMC83629.1 - 4.6e-18 65.4 0.5 3.7e-15 56.1 0.0 2.5 2 0 0 2 2 2 2 ZU5 domain Peptidase_S68 PF10461.9 EMC83629.1 - 3.4e-17 62.3 14.2 3.7e-16 59.0 7.5 2.7 2 0 0 2 2 2 2 Peptidase S68 LRR_4 PF12799.7 EMC83629.1 - 1.3e-14 54.1 31.0 4e-06 27.1 2.6 6.6 4 2 4 8 8 8 5 Leucine Rich repeats (2 copies) Death PF00531.22 EMC83629.1 - 6.3e-12 45.5 0.1 2.3e-11 43.7 0.1 2.0 1 0 0 1 1 1 1 Death domain LRR_1 PF00560.33 EMC83629.1 - 8.4 7.4 32.9 1.6 9.6 1.6 7.9 6 3 1 7 7 7 0 Leucine Rich Repeat Ribosomal_60s PF00428.19 EMC83630.1 - 3.6e-06 27.5 0.1 4.2e-06 27.3 0.1 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein EF-hand_14 PF17959.1 EMC83630.1 - 0.09 13.1 0.0 0.09 13.1 0.0 1.1 1 0 0 1 1 1 0 EF-hand domain Patatin PF01734.22 EMC83631.1 - 8.7e-13 48.9 4.0 7.2e-11 42.7 4.0 2.3 1 1 0 1 1 1 1 Patatin-like phospholipase EF-hand_7 PF13499.6 EMC83632.1 - 8.9e-09 35.7 0.3 4.8e-06 26.9 0.1 3.7 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.6 EMC83632.1 - 2.2e-06 27.2 0.1 0.01 15.7 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EMC83632.1 - 3.8e-06 26.1 0.4 0.033 13.7 0.1 3.1 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EMC83632.1 - 0.032 14.1 0.0 0.12 12.2 0.0 2.0 1 1 0 1 1 1 0 EF-hand domain pair Peptidase_S46 PF10459.9 EMC83632.1 - 9.7 4.7 16.2 16 4.0 16.2 1.3 1 0 0 1 1 1 0 Peptidase S46 Ras PF00071.22 EMC83633.1 - 6.3e-52 175.4 0.3 7e-52 175.3 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC83633.1 - 8.7e-32 109.9 0.1 1.2e-31 109.4 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC83633.1 - 1.6e-15 57.0 0.0 2e-15 56.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EMC83633.1 - 2.8e-10 39.9 0.1 3.1e-10 39.8 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EMC83633.1 - 1.3e-09 37.9 0.0 6.3e-09 35.7 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EMC83633.1 - 5.1e-09 36.2 0.0 6.5e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC83633.1 - 5.8e-05 23.1 0.0 0.0049 16.8 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 EMC83633.1 - 0.013 15.6 0.1 2.1 8.4 0.1 2.2 1 1 1 2 2 2 0 Dynamin family SRPRB PF09439.10 EMC83633.1 - 0.019 14.4 0.0 0.021 14.3 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Septin PF00735.18 EMC83633.1 - 0.03 13.6 0.0 0.043 13.1 0.0 1.2 1 0 0 1 1 1 0 Septin AAA_33 PF13671.6 EMC83633.1 - 0.033 14.4 0.0 0.04 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain CENP-M PF11111.8 EMC83633.1 - 0.038 13.2 0.0 0.056 12.6 0.0 1.3 1 0 0 1 1 1 0 Centromere protein M (CENP-M) AAA_7 PF12775.7 EMC83633.1 - 0.049 13.2 0.0 0.12 11.8 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA PF00004.29 EMC83633.1 - 0.12 12.8 0.0 0.19 12.2 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Plasmod_Pvs28 PF06247.11 EMC83633.1 - 0.14 12.5 0.1 0.25 11.7 0.1 1.4 1 0 0 1 1 1 0 Pvs28 EGF domain Tetraspanin PF00335.20 EMC83634.1 - 5e-44 150.7 17.8 4.6e-36 124.7 7.5 2.0 1 1 1 2 2 2 2 Tetraspanin family EI24 PF07264.11 EMC83634.1 - 0.00012 22.3 0.3 0.00018 21.8 0.3 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) DUF4500 PF14937.6 EMC83634.1 - 0.23 11.5 2.0 16 5.6 0.0 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4500) Baculo_11_kDa PF06143.11 EMC83634.1 - 0.89 9.2 9.9 8.9 6.0 6.6 2.5 2 1 0 2 2 2 0 Baculovirus 11 kDa family VitD-bind_III PF09164.10 EMC83634.1 - 3.1 7.8 6.0 0.34 10.9 0.4 2.3 2 1 1 3 3 3 0 Vitamin D binding protein, domain III DUF373 PF04123.13 EMC83634.1 - 3.3 7.1 7.5 2.8 7.3 5.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF373) Yip1 PF04893.17 EMC83634.1 - 5.6 6.7 17.0 1.3 8.7 13.9 1.4 2 0 0 2 2 2 0 Yip1 domain RNA_pol_N PF01194.17 EMC83635.1 - 1.3e-33 115.0 0.2 1.5e-33 114.9 0.2 1.0 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Tetraspanin PF00335.20 EMC83636.1 - 1.6e-49 168.7 14.9 1.8e-49 168.6 14.9 1.0 1 0 0 1 1 1 1 Tetraspanin family CD20 PF04103.15 EMC83636.1 - 0.00057 20.0 5.6 0.00057 20.0 5.6 1.7 2 0 0 2 2 2 1 CD20-like family GP38 PF05268.11 EMC83636.1 - 0.053 13.2 0.0 0.081 12.6 0.0 1.2 1 0 0 1 1 1 0 Phage tail fibre adhesin Gp38 MARVEL PF01284.23 EMC83636.1 - 7.3 6.6 14.2 0.89 9.6 8.2 2.0 2 0 0 2 2 2 0 Membrane-associating domain DUF2207 PF09972.9 EMC83636.1 - 8 5.1 7.5 0.94 8.2 3.4 1.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Glyco_hydro_18 PF00704.28 EMC83637.1 - 6.5e-20 72.1 0.0 7.8e-20 71.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DUF2202 PF09968.9 EMC83637.1 - 0.037 13.9 0.1 0.063 13.1 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein domain (DUF2202) Adaptin_N PF01602.20 EMC83638.1 - 6e-146 487.1 4.3 7.5e-146 486.7 4.3 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 EMC83638.1 - 2.5e-45 153.3 0.0 6.6e-45 151.9 0.0 1.8 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 EMC83638.1 - 4.5e-12 46.3 0.1 1.1e-11 45.0 0.1 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 EMC83638.1 - 4.7e-09 36.5 0.4 1e-06 28.9 0.0 2.7 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EMC83638.1 - 1.1e-05 25.7 3.7 0.0029 17.9 0.2 4.7 3 1 1 4 4 4 1 HEAT repeats RIX1 PF08167.12 EMC83638.1 - 0.00099 18.9 2.8 0.12 12.1 0.2 3.5 3 1 0 3 3 3 1 rRNA processing/ribosome biogenesis TIP120 PF08623.10 EMC83638.1 - 0.023 14.5 1.5 4.1 7.2 0.1 2.5 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) IFRD PF05004.13 EMC83638.1 - 0.59 9.2 3.7 0.56 9.3 0.6 2.4 3 0 0 3 3 3 0 Interferon-related developmental regulator (IFRD) DAN PF03045.15 EMC83639.1 - 5.3e-05 23.2 8.0 0.00036 20.5 8.4 2.1 2 0 0 2 2 2 1 DAN domain Cys_knot PF00007.22 EMC83639.1 - 0.0047 17.2 12.0 0.0096 16.2 12.0 1.6 1 0 0 1 1 1 1 Cystine-knot domain VWD PF00094.25 EMC83640.1 - 1.8e-76 255.8 27.7 8.3e-30 104.1 1.5 4.2 5 0 0 5 5 5 3 von Willebrand factor type D domain C8 PF08742.11 EMC83640.1 - 2e-37 127.4 38.6 1.7e-17 63.6 12.3 6.1 6 1 1 7 7 7 3 C8 domain TIL PF01826.17 EMC83640.1 - 2.8e-17 62.7 54.6 1.2e-10 41.4 17.8 9.3 9 2 1 10 10 10 3 Trypsin Inhibitor like cysteine rich domain VWC PF00093.18 EMC83640.1 - 2e-06 28.0 20.1 1.2e-05 25.5 4.0 9.7 7 3 1 8 8 8 2 von Willebrand factor type C domain VWD PF00094.25 EMC83641.1 - 3.2e-27 95.7 0.3 5.4e-27 95.0 0.3 1.3 1 0 0 1 1 1 1 von Willebrand factor type D domain C8 PF08742.11 EMC83641.1 - 1.1e-15 57.8 10.7 2.5e-15 56.6 10.7 1.7 1 0 0 1 1 1 1 C8 domain VWD PF00094.25 EMC83642.1 - 2.3e-29 102.7 2.9 2.3e-29 102.7 2.9 2.1 2 1 0 2 2 2 1 von Willebrand factor type D domain C8 PF08742.11 EMC83642.1 - 9.6e-17 61.2 15.5 9.6e-17 61.2 15.5 2.4 3 0 0 3 3 3 1 C8 domain Pacifastin_I PF05375.13 EMC83642.1 - 6.7e-05 22.5 12.7 6.7e-05 22.5 12.7 3.8 2 1 0 2 2 2 1 Pacifastin inhibitor (LCMII) TIL PF01826.17 EMC83642.1 - 0.0014 18.8 6.0 0.0014 18.8 6.0 4.8 4 1 0 4 4 4 1 Trypsin Inhibitor like cysteine rich domain Pkinase PF00069.25 EMC83644.1 - 4e-32 111.6 0.0 6.4e-32 111.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC83644.1 - 1e-19 70.8 0.0 1.6e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC83644.1 - 0.046 12.5 0.3 0.11 11.2 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase AMP-binding PF00501.28 EMC83645.1 - 8.9e-83 278.2 0.1 1.1e-82 277.9 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMC83645.1 - 1.5e-22 80.3 1.0 3.7e-22 79.1 1.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Str_synth PF03088.16 EMC83646.1 - 7.9e-30 102.8 0.2 3.3e-29 100.9 0.0 2.2 2 1 0 2 2 2 1 Strictosidine synthase SGL PF08450.12 EMC83646.1 - 2e-14 53.8 0.0 3e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 EMC83646.1 - 0.00023 21.1 0.0 0.13 12.4 0.0 4.4 5 0 0 5 5 5 1 NHL repeat Arylesterase PF01731.20 EMC83646.1 - 0.00043 20.4 0.0 0.061 13.5 0.0 3.1 3 1 0 3 3 3 1 Arylesterase PQQ_3 PF13570.6 EMC83646.1 - 0.039 14.5 0.0 2.4 8.8 0.0 3.2 3 1 0 3 3 3 0 PQQ-like domain Cystatin PF00031.21 EMC83647.1 - 2e-15 56.8 0.0 2.3e-15 56.6 0.0 1.1 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.5 EMC83647.1 - 0.0013 19.0 0.0 0.002 18.4 0.0 1.2 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor YmzC PF14157.6 EMC83647.1 - 0.038 14.1 0.0 0.056 13.5 0.0 1.3 1 0 0 1 1 1 0 YmzC-like protein RNA_POL_M_15KD PF02150.16 EMC83648.1 - 0.024 14.5 0.7 0.063 13.2 0.7 1.7 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit DUF3088 PF11287.8 EMC83648.1 - 0.12 12.2 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3088) NMDAR2_C PF10565.9 EMC83648.1 - 0.41 9.5 2.0 0.46 9.3 2.0 1.1 1 0 0 1 1 1 0 N-methyl D-aspartate receptor 2B3 C-terminus RRM_5 PF13893.6 EMC83649.1 - 7.8e-61 203.2 0.9 3.8e-55 184.8 0.1 3.2 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 EMC83649.1 - 2.2e-18 65.8 0.2 4.7e-07 29.5 0.1 4.2 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 EMC83649.1 - 1.9e-09 37.6 0.0 8.3e-09 35.5 0.0 2.1 3 0 0 3 3 3 1 RRM-like domain RRM_occluded PF16842.5 EMC83649.1 - 8.7e-05 22.3 0.0 0.67 9.9 0.0 2.7 3 0 0 3 3 3 2 Occluded RNA-recognition motif RL PF17797.1 EMC83649.1 - 0.00038 20.3 0.1 1.8 8.6 0.0 3.4 3 0 0 3 3 3 1 RL domain RRM_3 PF08777.11 EMC83649.1 - 0.0014 18.6 0.0 0.0056 16.7 0.0 1.9 2 0 0 2 2 2 1 RNA binding motif Limkain-b1 PF11608.8 EMC83649.1 - 0.0084 16.2 0.0 1.2 9.3 0.0 3.0 3 0 0 3 3 3 1 Limkain b1 DUF4523 PF15023.6 EMC83649.1 - 0.14 12.0 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) Aldose_epim PF01263.20 EMC83650.1 - 1.4e-93 313.5 0.2 1.6e-93 313.4 0.2 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase RRM_1 PF00076.22 EMC83651.1 - 1.7e-17 63.0 0.0 2.4e-17 62.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMC83651.1 - 0.00041 20.0 0.0 0.0006 19.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 EMC83651.1 - 0.0005 20.0 7.7 0.0011 19.0 7.7 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 EMC83651.1 - 0.00073 19.5 2.3 0.0017 18.2 2.3 1.7 1 0 0 1 1 1 1 Zinc knuckle RRM_7 PF16367.5 EMC83651.1 - 0.072 13.2 0.1 1.6 8.9 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif Gemin6 PF06372.12 EMC83652.1 - 1e-65 220.3 0.6 1.1e-65 220.2 0.6 1.0 1 0 0 1 1 1 1 Gemin6 protein Ish1 PF10281.9 EMC83652.1 - 0.041 14.2 0.0 0.094 13.0 0.0 1.5 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein 53-BP1_Tudor PF09038.10 EMC83652.1 - 0.064 13.2 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Tumour suppressor p53-binding protein-1 Tudor AD PF09793.9 EMC83652.1 - 0.083 13.0 0.0 0.24 11.5 0.0 1.6 1 1 0 1 1 1 0 Anticodon-binding domain RRM_1 PF00076.22 EMC83653.1 - 8.6e-17 60.7 0.0 1.2e-16 60.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 EMC83653.1 - 0.00046 20.1 7.7 0.00091 19.2 7.7 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 EMC83653.1 - 0.00054 19.9 2.3 0.0014 18.5 2.3 1.8 1 0 0 1 1 1 1 Zinc knuckle RRM_5 PF13893.6 EMC83653.1 - 0.0013 18.4 0.0 0.0018 17.9 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMC83653.1 - 0.03 14.2 0.0 0.042 13.7 0.0 1.1 1 0 0 1 1 1 0 Occluded RNA-recognition motif DUF3097 PF11296.8 EMC83653.1 - 4.1 6.5 5.6 10 5.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3097) OB_NTP_bind PF07717.16 EMC83655.1 - 7.5e-21 74.3 0.0 4.6e-20 71.8 0.0 2.4 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EMC83655.1 - 7.3e-18 64.8 0.6 5.2e-17 62.1 0.0 2.7 3 0 0 3 3 3 1 Helicase associated domain (HA2) RWD PF05773.22 EMC83655.1 - 2.4e-14 53.6 0.5 9.9e-14 51.6 0.0 2.4 2 0 0 2 2 2 1 RWD domain Helicase_C PF00271.31 EMC83655.1 - 4.5e-14 52.7 0.1 3.6e-13 49.8 0.0 2.5 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EMC83655.1 - 1.1e-10 41.5 0.2 2.5e-10 40.4 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-CCCH_4 PF18044.1 EMC83655.1 - 8.7e-09 35.0 3.3 2.2e-08 33.7 3.3 1.7 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 EMC83655.1 - 1.4e-06 28.9 0.2 5.7e-06 27.0 0.2 2.0 1 0 0 1 1 1 1 Torus domain zf_CCCH_4 PF18345.1 EMC83655.1 - 4.3e-05 23.4 7.8 4.3e-05 23.4 7.8 2.6 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH PF00642.24 EMC83655.1 - 0.00012 21.8 4.9 0.00012 21.8 4.9 1.8 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) AAA_22 PF13401.6 EMC83655.1 - 0.0016 18.7 0.2 0.0074 16.6 0.2 2.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EMC83655.1 - 0.0018 18.6 0.0 0.0075 16.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain zf-CCCH_2 PF14608.6 EMC83655.1 - 0.025 15.0 3.2 0.055 14.0 3.2 1.6 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger T2SSE PF00437.20 EMC83655.1 - 0.029 13.4 0.0 0.067 12.2 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_14 PF13173.6 EMC83655.1 - 0.035 14.1 1.7 0.25 11.4 0.0 3.1 2 1 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EMC83655.1 - 0.1 12.3 0.0 0.1 12.3 0.0 1.9 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase UBA PF00627.31 EMC83655.1 - 0.15 12.0 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 UBA/TS-N domain MORN PF02493.20 EMC83656.1 - 1.1e-05 25.0 1.4 1.2e-05 24.9 0.1 1.8 2 0 0 2 2 2 1 MORN repeat RhoGEF PF00621.20 EMC83657.1 - 1.2e-15 58.2 4.6 1.2e-15 58.2 4.6 1.7 2 0 0 2 2 2 1 RhoGEF domain RasGEF PF00617.19 EMC83659.1 - 2e-49 168.2 0.4 4.2e-49 167.1 0.4 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EMC83659.1 - 2.2e-31 108.2 0.0 7.6e-31 106.5 0.0 2.0 1 0 0 1 1 1 1 RasGEF N-terminal motif RhoGEF PF00621.20 EMC83659.1 - 2.2e-16 60.6 1.5 5.7e-16 59.3 0.1 2.4 2 0 0 2 2 2 1 RhoGEF domain Histone PF00125.24 EMC83659.1 - 6.4e-13 49.2 0.0 1.8e-12 47.7 0.0 1.8 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PH PF00169.29 EMC83659.1 - 5.3e-11 43.0 2.4 5.7e-11 42.9 0.0 2.3 3 0 0 3 3 3 1 PH domain PH_10 PF15411.6 EMC83659.1 - 0.0013 19.0 0.1 0.0049 17.1 0.1 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 EMC83659.1 - 0.0017 18.3 0.0 0.0071 16.3 0.0 2.0 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 EMC83659.1 - 0.0023 17.8 0.1 0.009 15.8 0.1 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain DUF445 PF04286.12 EMC83659.1 - 0.22 11.3 4.5 6.6 6.4 0.6 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF445) CNH PF00780.22 EMC83660.1 - 8.1e-31 107.6 0.7 9.3e-31 107.4 0.7 1.0 1 0 0 1 1 1 1 CNH domain QVR PF17064.5 EMC83660.1 - 0.02 15.1 0.2 0.031 14.5 0.2 1.3 1 0 0 1 1 1 0 Sleepless protein 7tm_4 PF13853.6 EMC83661.1 - 9e-09 35.5 0.5 9.7e-09 35.3 0.5 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC83661.1 - 2.2e-07 30.5 0.1 3.3e-07 29.9 0.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-C2H2 PF00096.26 EMC83664.1 - 7e-13 48.3 16.9 0.00012 22.3 3.7 4.2 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC83664.1 - 9.6e-13 47.9 8.8 2.3e-07 30.9 1.3 4.7 4 1 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC83664.1 - 1.7e-09 37.7 17.1 0.0026 18.4 2.0 5.1 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC83664.1 - 0.0077 16.2 6.9 1.1 9.4 0.5 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EMC83664.1 - 0.017 15.4 9.8 0.18 12.1 6.0 3.1 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-C2HC_2 PF13913.6 EMC83664.1 - 0.067 13.1 11.1 2.9 7.9 0.7 3.8 3 0 0 3 3 3 0 zinc-finger of a C2HC-type Zf_RING PF16744.5 EMC83664.1 - 0.24 11.5 1.7 1.8 8.8 0.9 2.5 1 1 1 2 2 2 0 KIAA1045 RING finger zf-BED PF02892.15 EMC83664.1 - 0.32 11.0 6.7 1.7 8.8 6.7 2.2 1 1 0 1 1 1 0 BED zinc finger zf-RRN7 PF11781.8 EMC83664.1 - 0.37 10.5 2.9 0.78 9.5 0.2 2.4 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-C2H2_11 PF16622.5 EMC83664.1 - 0.95 9.3 8.4 17 5.3 0.3 3.8 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-met PF12874.7 EMC83664.1 - 2.8 8.5 8.5 5.5 7.5 0.5 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type F-box-like PF12937.7 EMC83665.1 - 8.5e-09 35.2 0.5 8.5e-09 35.2 0.5 2.6 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 EMC83665.1 - 0.0001 22.1 0.8 0.00069 19.4 0.1 2.3 2 0 0 2 2 2 1 F-box domain Borrelia_P83 PF05262.11 EMC83665.1 - 0.00025 19.7 5.6 0.00034 19.3 5.6 1.1 1 0 0 1 1 1 1 Borrelia P83/100 protein zf-C2H2 PF00096.26 EMC83665.1 - 0.0064 16.9 2.1 0.016 15.6 2.1 1.8 1 0 0 1 1 1 1 Zinc finger, C2H2 type Exonuc_VII_L PF02601.15 EMC83665.1 - 0.0091 15.6 8.1 0.014 15.0 8.1 1.2 1 0 0 1 1 1 1 Exonuclease VII, large subunit LUC7 PF03194.15 EMC83665.1 - 0.011 15.5 3.5 0.02 14.6 3.5 1.4 1 0 0 1 1 1 0 LUC7 N_terminus Atg14 PF10186.9 EMC83665.1 - 0.018 14.1 16.5 0.029 13.5 16.5 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF572 PF04502.13 EMC83665.1 - 0.028 14.1 3.3 0.041 13.5 3.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) zf-C2H2_4 PF13894.6 EMC83665.1 - 0.09 13.7 1.6 0.31 12.0 1.6 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC83665.1 - 0.14 12.2 1.3 0.44 10.6 1.3 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger Peptidase_C50 PF03568.17 EMC83665.1 - 1.3 8.1 10.9 2.2 7.3 10.9 1.2 1 0 0 1 1 1 0 Peptidase family C50 hDGE_amylase PF14701.6 EMC83665.1 - 1.6 7.8 6.0 2.4 7.2 6.0 1.1 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain UPF0242 PF06785.11 EMC83665.1 - 2.5 8.2 20.6 4.3 7.4 20.6 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus PA PF02225.22 EMC83666.1 - 3.2e-06 27.1 0.0 4.4e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 PA domain SET PF00856.28 EMC83667.1 - 1.5e-13 51.5 0.1 7.5e-13 49.2 0.1 2.0 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.18 EMC83667.1 - 3.7e-06 26.9 13.3 3.7e-06 26.9 13.3 3.0 3 2 0 3 3 3 1 MYND finger zf-HIT PF04438.16 EMC83667.1 - 0.012 15.5 4.2 0.012 15.5 4.2 2.8 2 0 0 2 2 2 0 HIT zinc finger Homeodomain PF00046.29 EMC83668.1 - 1.7e-22 79.0 4.7 2.2e-22 78.6 4.7 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC83668.1 - 0.051 13.5 0.1 0.094 12.6 0.1 1.5 1 0 0 1 1 1 0 Homeobox KN domain Homeodomain PF00046.29 EMC83669.1 - 1.2e-22 79.4 3.3 1.9e-22 78.9 3.3 1.3 1 0 0 1 1 1 1 Homeodomain RBD-FIP PF09457.10 EMC83670.1 - 6.1e-10 38.9 8.7 6.1e-10 38.9 8.7 1.9 2 1 0 2 2 2 1 FIP domain Mtc PF03820.17 EMC83671.1 - 1.9e-110 368.8 0.6 2.1e-110 368.6 0.6 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier DUF1980 PF09323.10 EMC83671.1 - 0.043 13.7 0.1 0.18 11.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Homeodomain PF00046.29 EMC83672.1 - 4.3e-05 23.3 1.4 7.3e-05 22.5 1.4 1.4 1 0 0 1 1 1 1 Homeodomain adh_short PF00106.25 EMC83674.1 - 6.6e-15 55.1 0.0 8.7e-15 54.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC83674.1 - 3.6e-09 36.5 0.0 3.9e-09 36.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase CHCH PF06747.13 EMC83674.1 - 0.0046 17.1 0.2 0.0087 16.2 0.2 1.5 1 0 0 1 1 1 1 CHCH domain Pkinase PF00069.25 EMC83675.1 - 1.2e-12 47.8 0.0 1.4e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC83675.1 - 0.00032 20.1 0.0 0.0004 19.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Astacin PF01400.24 EMC83677.1 - 2.7e-60 203.3 0.5 3.8e-60 202.8 0.0 1.4 2 0 0 2 2 2 1 Astacin (Peptidase family M12A) CUB PF00431.20 EMC83677.1 - 5.2e-29 100.8 0.0 1.4e-28 99.4 0.0 1.7 2 0 0 2 2 2 1 CUB domain SH3_9 PF14604.6 EMC83679.1 - 1.3e-10 41.0 0.0 2.7e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC83679.1 - 0.00093 18.8 0.0 0.0018 17.8 0.0 1.5 1 0 0 1 1 1 1 SH3 domain Wtap PF17098.5 EMC83679.1 - 0.074 13.0 0.5 1.3 8.9 0.1 2.4 2 0 0 2 2 2 0 WTAP/Mum2p family GrpE PF01025.19 EMC83679.1 - 0.18 11.4 0.3 0.38 10.4 0.3 1.6 1 0 0 1 1 1 0 GrpE C1q PF00386.21 EMC83680.1 - 9.9e-72 239.1 2.0 2.3e-38 131.3 0.1 2.1 2 0 0 2 2 2 2 C1q domain BclA_C PF18573.1 EMC83680.1 - 2.4e-07 30.7 0.0 0.0095 15.9 0.0 2.2 2 0 0 2 2 2 2 BclA C-terminal domain Rhodanese PF00581.20 EMC83680.1 - 0.00057 20.4 0.0 0.66 10.5 0.0 2.3 2 0 0 2 2 2 2 Rhodanese-like domain DUF3531 PF12049.8 EMC83680.1 - 0.043 13.7 0.1 11 5.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3531) FAM180 PF15173.6 EMC83681.1 - 9e-24 84.0 0.0 1e-23 83.8 0.0 1.0 1 0 0 1 1 1 1 FAM180 family Complex1_30kDa PF00329.19 EMC83682.1 - 1.5e-43 148.3 0.0 2e-43 147.9 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit BTB PF00651.31 EMC83683.1 - 2.5e-26 92.1 2.3 4.6e-26 91.2 2.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.6 EMC83683.1 - 6.5e-18 64.3 4.5 5.2e-06 26.5 0.0 5.2 4 1 1 5 5 5 3 Kelch motif BACK PF07707.15 EMC83683.1 - 4.6e-10 39.5 0.9 4.3e-08 33.2 0.1 2.5 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_2 PF07646.15 EMC83683.1 - 3.6e-07 29.9 0.4 0.048 13.6 0.1 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 EMC83683.1 - 2.1e-06 27.2 1.0 0.026 14.1 0.0 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 EMC83683.1 - 0.00045 20.2 0.4 0.1 12.6 0.0 3.4 3 0 0 3 3 3 1 Galactose oxidase, central domain DSPc PF00782.20 EMC83684.1 - 6.3e-19 68.1 0.1 7.4e-19 67.9 0.1 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC83684.1 - 4.1e-05 23.3 0.6 0.00015 21.4 0.6 1.8 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DSPn PF14671.6 EMC83684.1 - 0.0015 19.0 0.0 0.0019 18.6 0.0 1.2 1 0 0 1 1 1 1 Dual specificity protein phosphatase, N-terminal half PTPlike_phytase PF14566.6 EMC83684.1 - 0.0083 16.2 0.0 0.013 15.6 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 EMC83684.1 - 0.014 15.0 0.1 0.014 14.9 0.1 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family RRM_1 PF00076.22 EMC83685.1 - 1.5e-51 172.1 0.0 2.3e-18 65.7 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 EMC83685.1 - 7.1e-10 38.8 0.0 0.1 12.7 0.0 3.9 3 2 0 3 3 3 3 RNA binding domain RRM_7 PF16367.5 EMC83685.1 - 0.0002 21.4 0.0 0.75 10.0 0.0 3.5 3 0 0 3 3 3 2 RNA recognition motif PHM7_cyt PF14703.6 EMC83685.1 - 0.0036 17.6 5.9 4.2 7.6 1.4 4.3 3 2 1 4 4 4 2 Cytosolic domain of 10TM putative phosphate transporter Nup35_RRM_2 PF14605.6 EMC83685.1 - 0.016 15.2 0.0 0.56 10.3 0.0 2.9 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif BRAP2 PF07576.12 EMC83685.1 - 0.083 13.1 0.1 4.3 7.6 0.0 2.8 3 0 0 3 3 3 0 BRCA1-associated protein 2 Rapsyn_N PF10579.9 EMC83687.1 - 8.4e-44 147.6 0.2 1e-42 144.1 0.1 2.6 2 0 0 2 2 2 1 Rapsyn N-terminal myristoylation and linker region TPR_1 PF00515.28 EMC83687.1 - 6.3e-21 73.3 11.6 0.00016 21.3 0.1 7.1 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 EMC83687.1 - 1.9e-20 72.9 4.8 8.8e-07 29.1 0.0 5.3 4 1 2 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 EMC83687.1 - 5e-16 57.5 11.2 0.0044 17.0 0.1 6.7 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 EMC83687.1 - 2.6e-10 39.7 11.2 0.035 14.3 0.1 6.2 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMC83687.1 - 3.4e-10 39.2 4.4 0.057 13.5 0.0 6.4 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EMC83687.1 - 4.9e-08 32.7 2.5 1.6e-06 27.8 0.4 2.8 2 1 1 3 3 3 1 MalT-like TPR region TPR_10 PF13374.6 EMC83687.1 - 9.4e-06 25.3 3.9 0.0013 18.6 0.2 4.9 6 0 0 6 6 5 1 Tetratricopeptide repeat DUF3856 PF12968.7 EMC83687.1 - 2.4e-05 24.4 2.0 0.37 10.8 0.0 3.8 3 1 1 4 4 4 2 Domain of Unknown Function (DUF3856) TPR_19 PF14559.6 EMC83687.1 - 7.9e-05 23.1 0.3 2.5 8.7 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat zf-RING_11 PF17123.5 EMC83687.1 - 0.00026 20.7 0.6 0.00026 20.7 0.6 2.9 3 0 0 3 3 2 1 RING-like zinc finger TPR_11 PF13414.6 EMC83687.1 - 0.00053 19.6 0.5 7.8 6.3 0.0 4.8 5 0 0 5 5 5 0 TPR repeat TPR_16 PF13432.6 EMC83687.1 - 0.0011 19.5 0.5 27 5.5 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat SNAP PF14938.6 EMC83687.1 - 0.0017 17.8 0.5 0.68 9.3 0.2 2.3 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 EMC83687.1 - 0.0019 18.7 5.5 1.7 9.5 0.1 5.4 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 EMC83687.1 - 0.0027 18.4 3.0 2.7 9.0 0.1 5.0 5 1 1 6 6 5 1 Tetratricopeptide repeat RPN7 PF10602.9 EMC83687.1 - 0.0069 16.1 6.0 1.1 9.0 1.2 3.7 2 1 2 4 4 4 1 26S proteasome subunit RPN7 Fis1_TPR_C PF14853.6 EMC83687.1 - 0.009 16.1 4.4 0.38 10.9 0.0 4.2 5 0 0 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat zf-RING_2 PF13639.6 EMC83687.1 - 0.024 15.0 0.3 0.024 15.0 0.3 3.9 4 0 0 4 4 4 0 Ring finger domain PCYCGC PF13798.6 EMC83687.1 - 0.037 13.9 2.4 0.097 12.5 1.1 2.4 3 0 0 3 3 3 0 Protein of unknown function with PCYCGC motif ANAPC5 PF12862.7 EMC83687.1 - 0.06 13.4 1.2 13 5.9 0.6 3.7 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 5 AKNA PF12443.8 EMC83687.1 - 0.12 13.0 0.2 0.34 11.6 0.2 1.7 1 0 0 1 1 1 0 AT-hook-containing transcription factor TPR_17 PF13431.6 EMC83687.1 - 0.47 10.9 6.2 22 5.7 0.8 5.0 4 1 0 4 4 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC83687.1 - 1.7 8.9 10.4 6.8 7.0 0.7 3.7 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 AAA PF00004.29 EMC83688.1 - 6.4e-42 143.1 0.0 1.2e-41 142.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EMC83688.1 - 4.3e-13 49.0 0.1 1.2e-12 47.6 0.1 1.8 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EMC83688.1 - 2.6e-10 40.0 1.1 4.1e-10 39.3 0.3 1.8 2 0 0 2 2 1 1 AAA+ lid domain AAA_5 PF07728.14 EMC83688.1 - 4.7e-06 26.7 0.1 2e-05 24.6 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EMC83688.1 - 1.6e-05 25.4 0.3 0.0036 17.7 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EMC83688.1 - 4.1e-05 23.4 0.0 0.00013 21.7 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EMC83688.1 - 0.00019 21.6 0.0 0.00062 19.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EMC83688.1 - 0.00051 20.3 0.3 0.082 13.2 0.1 2.5 1 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EMC83688.1 - 0.003 17.7 0.1 0.0064 16.7 0.1 1.8 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 EMC83688.1 - 0.0031 16.7 0.0 0.0053 15.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) PhoH PF02562.16 EMC83688.1 - 0.0041 16.6 0.1 0.019 14.4 0.0 2.0 2 0 0 2 2 2 1 PhoH-like protein Mg_chelatase PF01078.21 EMC83688.1 - 0.0052 16.2 0.1 0.015 14.7 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Prot_ATP_OB_N PF17758.1 EMC83688.1 - 0.018 14.6 0.0 1.9 8.2 0.0 2.5 2 0 0 2 2 2 0 Proteasomal ATPase OB N-terminal domain IstB_IS21 PF01695.17 EMC83688.1 - 0.023 14.5 0.0 0.04 13.6 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Sigma54_activat PF00158.26 EMC83688.1 - 0.038 13.7 0.0 0.25 11.0 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.6 EMC83688.1 - 0.041 13.6 0.2 0.13 12.0 0.2 1.9 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 EMC83688.1 - 0.057 12.7 0.0 0.18 11.2 0.0 1.8 2 0 0 2 2 2 0 KaiC AAA_7 PF12775.7 EMC83688.1 - 0.08 12.5 0.0 0.19 11.2 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_11 PF13086.6 EMC83688.1 - 0.08 12.7 0.2 0.52 10.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain Urm1 PF09138.11 EMC83688.1 - 0.091 13.1 0.0 0.23 11.8 0.0 1.6 1 0 0 1 1 1 0 Urm1 (Ubiquitin related modifier) TIP49 PF06068.13 EMC83688.1 - 0.1 11.8 0.0 0.2 10.8 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain RNA_helicase PF00910.22 EMC83688.1 - 0.15 12.5 0.0 0.34 11.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_25 PF13481.6 EMC83688.1 - 0.16 11.5 0.9 1.3 8.5 0.2 2.2 1 1 1 2 2 2 0 AAA domain Claudin_2 PF13903.6 EMC83689.1 - 5.4e-15 55.7 2.8 6.3e-15 55.4 2.8 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 EMC83689.1 - 0.0016 18.3 3.9 0.0027 17.6 3.9 1.4 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Zip PF02535.22 EMC83690.1 - 7.5e-57 193.0 8.7 3.6e-56 190.8 8.7 1.8 1 1 0 1 1 1 1 ZIP Zinc transporter ABC2_membrane_3 PF12698.7 EMC83690.1 - 0.79 8.8 5.6 0.078 12.1 0.4 1.8 2 0 0 2 2 2 0 ABC-2 family transporter protein Ets PF00178.22 EMC83691.1 - 2.2e-23 82.5 2.9 3.5e-23 81.9 2.9 1.3 1 0 0 1 1 1 1 Ets-domain I-set PF07679.16 EMC83692.1 - 3e-105 344.5 14.0 6.8e-17 61.3 0.0 9.3 9 1 0 9 9 9 8 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC83692.1 - 9.7e-73 240.8 1.0 6.4e-13 49.1 0.0 8.6 8 0 0 8 8 8 8 Immunoglobulin domain fn3 PF00041.21 EMC83692.1 - 5.7e-41 138.8 0.0 1.8e-12 47.4 0.0 4.2 4 0 0 4 4 4 3 Fibronectin type III domain ig PF00047.25 EMC83692.1 - 6.1e-41 138.5 4.9 4.7e-08 33.1 0.0 8.5 8 0 0 8 8 8 8 Immunoglobulin domain Ig_2 PF13895.6 EMC83692.1 - 2.3e-32 111.2 0.4 3.8e-05 23.9 0.0 8.9 7 2 1 8 8 8 6 Immunoglobulin domain THB PF18362.1 EMC83692.1 - 1e-21 76.2 0.1 2e-21 75.3 0.1 1.5 1 0 0 1 1 1 1 Tri-helix bundle domain V-set PF07686.17 EMC83692.1 - 2e-20 73.0 9.6 0.0066 16.6 0.0 11.2 7 5 2 9 9 9 5 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC83692.1 - 3.1e-09 36.8 0.2 0.075 13.1 0.0 6.2 5 1 0 5 5 5 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 EMC83692.1 - 4.4e-05 23.8 6.3 20 5.7 0.0 7.0 6 1 1 7 7 7 0 Immunoglobulin C1-set domain PKD_3 PF16820.5 EMC83692.1 - 0.00085 19.0 6.0 0.32 10.8 0.1 5.1 5 0 0 5 5 5 1 PKD-like domain zf-C4 PF00105.18 EMC83693.1 - 8.6e-28 96.6 15.5 1.4e-27 95.9 15.5 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 EMC83693.1 - 1.8e-27 96.3 2.0 3.5e-27 95.3 2.0 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor His_Phos_2 PF00328.22 EMC83696.1 - 3.2e-20 72.9 0.0 3.8e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) WD40 PF00400.32 EMC83697.1 - 1.5e-10 41.5 10.7 0.00019 22.2 0.1 6.1 7 0 0 7 7 7 3 WD domain, G-beta repeat FCH PF00611.23 EMC83698.1 - 1.2e-17 63.9 0.2 1.2e-17 63.9 0.2 2.4 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 EMC83698.1 - 9.9e-16 57.1 0.8 3.8e-15 55.2 0.0 2.2 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EMC83698.1 - 4.5e-15 55.2 0.1 1e-14 54.1 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC83698.1 - 7.8e-09 35.1 0.8 3.9e-08 32.9 0.0 2.6 3 0 0 3 3 3 1 Variant SH3 domain hDGE_amylase PF14701.6 EMC83698.1 - 0.015 14.4 4.6 0.023 13.8 4.6 1.3 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain bZIP_Maf PF03131.17 EMC83698.1 - 0.077 13.5 8.5 0.22 12.1 8.5 1.8 1 0 0 1 1 1 0 bZIP Maf transcription factor DUF3086 PF11285.8 EMC83698.1 - 0.08 12.0 0.2 0.08 12.0 0.2 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF3086) EzrA PF06160.12 EMC83698.1 - 0.15 10.2 12.0 0.12 10.6 10.3 1.6 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Tho2 PF11262.8 EMC83698.1 - 0.21 10.7 12.0 0.19 10.9 10.2 1.8 1 1 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF3391 PF11871.8 EMC83698.1 - 0.37 11.3 4.5 0.72 10.4 4.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) DUF641 PF04859.12 EMC83698.1 - 0.39 11.1 7.7 0.77 10.1 7.7 1.5 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Atg14 PF10186.9 EMC83698.1 - 0.45 9.6 7.8 0.72 8.9 7.8 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 POX PF07526.11 EMC83698.1 - 1 10.0 7.0 2.3 8.8 7.0 1.6 1 0 0 1 1 1 0 Associated with HOX PKK PF12474.8 EMC83698.1 - 1 9.5 23.2 0.095 12.8 5.3 3.3 2 1 1 3 3 3 0 Polo kinase kinase CorA PF01544.18 EMC83698.1 - 1.9 7.7 4.3 0.38 10.0 0.8 1.6 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein NDUFB10 PF10249.9 EMC83698.1 - 2.3 8.7 13.8 0.26 11.8 4.2 2.9 2 1 1 3 3 3 0 NADH-ubiquinone oxidoreductase subunit 10 LMBR1 PF04791.16 EMC83698.1 - 2.5 6.9 3.6 3.1 6.6 3.6 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein ArfGap PF01412.18 EMC83699.1 - 1.9e-27 95.6 1.6 4.4e-27 94.5 1.6 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Ldl_recept_b PF00058.17 EMC83701.1 - 2.7e-191 619.9 65.2 8.3e-14 51.8 0.3 20.6 20 0 0 20 20 20 20 Low-density lipoprotein receptor repeat class B Ldl_recept_a PF00057.18 EMC83701.1 - 3.2e-90 296.0 171.0 8.1e-13 48.4 16.2 9.1 8 0 0 8 8 8 8 Low-density lipoprotein receptor domain class A FXa_inhibition PF14670.6 EMC83701.1 - 4.1e-46 154.9 117.8 3.2e-12 46.5 8.3 8.6 8 0 0 8 8 6 6 Coagulation Factor Xa inhibitory site SGL PF08450.12 EMC83701.1 - 1.9e-32 112.8 30.1 1.6e-08 34.5 4.2 11.5 3 3 3 9 9 9 7 SMP-30/Gluconolactonase/LRE-like region DUF5050 PF16472.5 EMC83701.1 - 7.7e-19 68.0 0.0 0.0013 18.0 0.0 5.3 4 2 0 4 4 4 4 Domain of unknown function (DUF5050) cEGF PF12662.7 EMC83701.1 - 5.3e-15 55.0 42.2 1.2e-08 34.7 0.8 7.7 6 0 0 6 6 6 5 Complement Clr-like EGF-like EGF_CA PF07645.15 EMC83701.1 - 3.2e-06 27.2 10.9 3.2e-06 27.2 10.9 11.3 9 2 1 11 11 6 1 Calcium-binding EGF domain Str_synth PF03088.16 EMC83701.1 - 0.0013 18.8 0.0 7.5 6.8 0.0 5.6 6 0 0 6 6 6 1 Strictosidine synthase EGF PF00008.27 EMC83701.1 - 0.0037 17.5 3.0 0.0037 17.5 3.0 12.1 12 1 0 12 12 11 5 EGF-like domain EGF_3 PF12947.7 EMC83701.1 - 0.0078 16.4 9.3 0.0078 16.4 9.3 9.9 11 1 0 11 11 7 3 EGF domain SBBP PF06739.11 EMC83701.1 - 0.047 13.7 2.0 10 6.2 0.0 4.6 5 0 0 5 5 5 0 Beta-propeller repeat SL4P PF17618.2 EMC83701.1 - 0.22 11.6 19.2 1.8 8.7 0.1 8.5 10 0 0 10 10 10 0 Uncharacterized Strongylid L4 protein Trypsin PF00089.26 EMC83702.1 - 4.2e-68 229.5 0.0 5.8e-68 229.0 0.0 1.2 1 0 0 1 1 1 1 Trypsin Kringle PF00051.18 EMC83702.1 - 1.8e-43 146.7 13.1 8.8e-23 80.4 4.6 2.6 2 0 0 2 2 2 2 Kringle domain Thrombin_light PF09396.10 EMC83702.1 - 2.2e-25 88.1 1.6 5.6e-25 86.8 1.6 1.7 1 0 0 1 1 1 1 Thrombin light chain Gla PF00594.20 EMC83702.1 - 9e-18 64.2 8.2 2.5e-17 62.8 8.2 1.8 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain DUF1986 PF09342.11 EMC83702.1 - 4.9e-06 26.9 0.1 1.1e-05 25.8 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) zf-H2C2_2 PF13465.6 EMC83703.1 - 4.9e-56 184.8 65.3 1.4e-09 37.9 0.4 11.1 11 0 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.26 EMC83703.1 - 5.4e-40 133.7 75.4 4.4e-07 30.0 0.5 10.2 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC83703.1 - 4.2e-37 123.6 73.3 0.00023 21.7 0.4 10.3 10 0 0 10 10 10 10 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC83703.1 - 8e-14 51.2 64.3 0.0017 18.3 0.3 10.5 10 2 0 10 10 10 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC83703.1 - 7.3e-12 45.2 34.0 0.0092 16.2 0.1 9.4 10 0 0 10 10 8 4 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 EMC83703.1 - 2.2e-10 40.1 62.1 0.0047 16.7 0.1 9.7 10 0 0 10 10 10 5 zinc-finger C2H2-type zf-Di19 PF05605.12 EMC83703.1 - 0.00019 21.7 1.7 0.00019 21.7 1.7 6.4 3 2 4 7 7 6 3 Drought induced 19 protein (Di19), zinc-binding GAGA PF09237.11 EMC83703.1 - 0.00063 19.5 0.3 0.00063 19.5 0.3 4.5 1 1 4 5 5 5 1 GAGA factor zf_Hakai PF18408.1 EMC83703.1 - 0.0017 18.1 3.1 1.8 8.3 1.2 3.6 2 0 0 2 2 2 2 C2H2 Hakai zinc finger domain FYDLN_acid PF09538.10 EMC83703.1 - 0.0032 18.1 18.6 4.1 8.1 0.0 6.1 3 3 2 5 5 5 1 Protein of unknown function (FYDLN_acid) zf-met PF12874.7 EMC83703.1 - 0.0033 17.8 1.4 0.08 13.4 0.5 9.0 10 0 0 10 10 8 2 Zinc-finger of C2H2 type zf-C2H2_3rep PF18868.1 EMC83703.1 - 0.012 16.3 37.3 1.4 9.6 5.4 7.6 3 3 2 5 5 5 0 Zinc finger C2H2-type, 3 repeats Zn-ribbon_8 PF09723.10 EMC83703.1 - 0.022 14.8 44.9 0.25 11.5 1.4 7.3 3 2 5 8 8 8 0 Zinc ribbon domain zf-C2HE PF16278.5 EMC83703.1 - 0.023 15.1 54.0 0.087 13.3 0.3 8.6 3 3 5 8 8 8 0 C2HE / C2H2 / C2HC zinc-binding finger zf_UBZ PF18439.1 EMC83703.1 - 0.079 12.6 43.7 2.2 8.0 0.2 9.1 10 0 0 10 10 10 0 Ubiquitin-Binding Zinc Finger BHD_1 PF10403.9 EMC83703.1 - 0.08 12.8 0.3 1.4 8.8 0.0 3.0 3 0 0 3 3 3 0 Rad4 beta-hairpin domain 1 Elf1 PF05129.13 EMC83703.1 - 0.14 12.3 0.2 0.14 12.3 0.2 6.0 2 1 4 7 7 7 0 Transcription elongation factor Elf1 like DUF2180 PF09947.9 EMC83703.1 - 0.18 11.8 0.1 0.18 11.8 0.1 6.5 6 3 2 9 9 7 0 Uncharacterized protein conserved in archaea (DUF2180) DUF3268 PF11672.8 EMC83703.1 - 0.28 11.5 0.1 0.28 11.5 0.1 4.7 3 1 3 6 6 6 0 zinc-finger-containing domain zf-LYAR PF08790.11 EMC83703.1 - 0.31 11.0 27.4 1.7 8.6 0.2 7.1 7 0 0 7 7 7 0 LYAR-type C2HC zinc finger zf-C2HC_2 PF13913.6 EMC83703.1 - 0.39 10.7 0.1 0.39 10.7 0.1 8.0 10 0 0 10 10 6 0 zinc-finger of a C2HC-type zf-C2H2_2 PF12756.7 EMC83703.1 - 0.75 10.2 0.1 0.75 10.2 0.1 8.7 1 1 7 9 9 9 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_15 PF17032.5 EMC83703.1 - 1.3 9.8 31.4 4.4 8.1 0.3 5.2 1 1 0 4 4 4 0 zinc-ribbon family zf-C2H2_9 PF16293.5 EMC83703.1 - 1.6 8.6 6.4 11 5.9 0.0 4.6 4 1 2 6 6 6 0 C2H2 type zinc-finger (1 copy) CpXC PF14353.6 EMC83703.1 - 2 8.4 33.0 2.3 8.3 0.2 7.0 3 2 4 8 8 8 0 CpXC protein C1_4 PF07975.12 EMC83703.1 - 3.6 7.9 39.1 0.056 13.7 3.2 6.9 4 3 3 7 7 7 0 TFIIH C1-like domain zf-CHY PF05495.12 EMC83703.1 - 3.9 8.0 44.5 0.19 12.2 3.2 5.8 1 1 5 6 6 5 0 CHY zinc finger zf-DNA_Pol PF08996.10 EMC83703.1 - 3.9 7.2 18.2 2.6 7.8 0.2 4.0 2 1 2 4 4 4 0 DNA Polymerase alpha zinc finger RhoGAP PF00620.27 EMC83704.1 - 1.1e-44 151.9 0.2 2.4e-44 150.8 0.2 1.5 1 0 0 1 1 1 1 RhoGAP domain CRAL_TRIO_2 PF13716.6 EMC83704.1 - 4.4e-40 137.0 3.3 4.9e-40 136.9 1.2 2.0 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 EMC83704.1 - 1.4e-09 37.9 0.2 2.8e-09 36.9 0.2 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain ATG13 PF10033.9 EMC83705.1 - 3.4e-14 53.1 0.3 7.6e-07 29.1 0.3 3.0 1 1 1 2 2 2 2 Autophagy-related protein 13 DDE_Tnp_4 PF13359.6 EMC83706.1 - 5.8e-37 126.8 0.0 7.9e-37 126.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.14 EMC83706.1 - 1.2e-06 28.3 0.0 6.1e-05 22.7 0.0 2.2 1 1 0 1 1 1 1 Plant transposon protein DDE_Tnp_1 PF01609.21 EMC83706.1 - 0.00036 20.2 0.1 0.14 11.8 0.0 2.1 1 1 1 2 2 2 2 Transposase DDE domain 7tm_1 PF00001.21 EMC83707.1 - 4.7e-75 252.3 6.4 6.6e-75 251.8 6.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC83707.1 - 3.6e-08 33.4 8.2 3.6e-08 33.4 8.2 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 EMC83707.1 - 7.9e-07 28.7 15.6 9.3e-06 25.2 6.3 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC83707.1 - 0.00022 21.0 8.6 0.00022 21.0 8.6 2.4 2 1 0 2 2 2 1 Olfactory receptor Orf78 PF06024.12 EMC83707.1 - 3.2 8.1 4.7 12 6.3 0.0 3.5 3 0 0 3 3 3 0 Orf78 (ac78) PTN_MK_N PF05196.13 EMC83708.1 - 3e-27 94.6 18.2 3e-27 94.6 18.2 2.4 2 1 0 2 2 2 1 PTN/MK heparin-binding protein family, N-terminal domain PTN_MK_C PF01091.18 EMC83708.1 - 2.3e-25 88.8 3.6 2.3e-25 88.8 3.6 2.7 2 1 0 2 2 2 1 PTN/MK heparin-binding protein family, C-terminal domain DAGK_acc PF00609.19 EMC83709.1 - 2.4e-39 135.2 0.0 4.6e-39 134.3 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 EMC83709.1 - 5.9e-29 100.2 0.0 1.4e-28 99.0 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Ank_2 PF12796.7 EMC83709.1 - 1.9e-12 47.6 0.1 5.4e-12 46.1 0.1 1.8 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) C1_1 PF00130.22 EMC83709.1 - 2.2e-12 46.7 26.0 3e-10 39.8 14.0 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Ank_3 PF13606.6 EMC83709.1 - 9.1e-10 38.0 0.0 0.0006 20.1 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EMC83709.1 - 2.8e-08 34.1 0.1 0.00033 21.2 0.0 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC83709.1 - 2.6e-07 30.8 0.0 0.0025 18.1 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EMC83709.1 - 0.00053 20.3 0.1 0.11 12.9 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat zf-C2H2_4 PF13894.6 EMC83709.1 - 9 7.4 9.1 43 5.3 0.6 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger Prok-RING_1 PF14446.6 EMC83709.1 - 9.3 6.3 8.6 3.7 7.6 1.5 2.8 2 1 0 2 2 2 0 Prokaryotic RING finger family 1 bZIP_1 PF00170.21 EMC83710.1 - 3.4e-16 59.1 14.5 5.7e-16 58.4 14.5 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMC83710.1 - 6e-09 35.9 9.3 6e-09 35.9 9.3 2.2 1 1 1 2 2 2 2 Basic region leucine zipper bZIP_Maf PF03131.17 EMC83710.1 - 2.4e-05 24.8 10.1 4.6e-05 23.9 10.1 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor Spc29 PF17082.5 EMC83710.1 - 0.0074 16.2 0.3 0.012 15.5 0.3 1.2 1 0 0 1 1 1 1 Spindle Pole Component 29 LMBR1 PF04791.16 EMC83710.1 - 0.013 14.4 0.0 0.016 14.1 0.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Tcf25 PF04910.14 EMC83710.1 - 0.038 13.1 0.2 0.048 12.7 0.2 1.1 1 0 0 1 1 1 0 Transcriptional repressor TCF25 DUF2046 PF09755.9 EMC83710.1 - 0.04 13.1 7.1 0.1 11.8 6.0 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) HAUS-augmin3 PF14932.6 EMC83710.1 - 0.046 13.3 5.5 0.07 12.7 5.5 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 APG6_N PF17675.1 EMC83710.1 - 0.058 13.9 7.2 0.1 13.1 7.2 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region JMY PF15871.5 EMC83710.1 - 0.059 12.7 4.8 0.1 11.9 4.8 1.3 1 0 0 1 1 1 0 Junction-mediating and -regulatory protein TPR_MLP1_2 PF07926.12 EMC83710.1 - 0.062 13.4 11.0 0.095 12.8 11.0 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF4337 PF14235.6 EMC83710.1 - 0.065 13.3 0.7 0.095 12.8 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Goodbye PF17109.5 EMC83710.1 - 0.089 13.2 0.2 0.15 12.5 0.2 1.4 1 0 0 1 1 1 0 fungal STAND N-terminal Goodbye domain Jnk-SapK_ap_N PF09744.9 EMC83710.1 - 0.13 12.5 6.7 0.21 11.8 6.7 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 ADIP PF11559.8 EMC83710.1 - 0.15 12.2 11.5 0.23 11.5 11.5 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF724 PF05266.14 EMC83710.1 - 0.4 10.5 4.6 0.64 9.8 4.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF4404 PF14357.6 EMC83710.1 - 0.41 11.3 2.7 0.51 11.0 0.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) DUF3552 PF12072.8 EMC83710.1 - 0.53 9.7 9.2 0.81 9.1 9.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) PHD PF00628.29 EMC83711.1 - 1.8e-12 47.0 6.6 3.8e-12 45.9 6.6 1.6 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 EMC83711.1 - 0.0034 17.6 0.1 0.014 15.6 0.1 2.0 1 0 0 1 1 1 1 PHD-like zinc-binding domain C1_1 PF00130.22 EMC83711.1 - 0.0049 16.7 2.0 0.0049 16.7 2.0 1.9 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) AT_hook PF02178.19 EMC83711.1 - 0.0086 15.8 1.8 0.025 14.4 1.8 1.8 1 0 0 1 1 1 1 AT hook motif PHD_2 PF13831.6 EMC83711.1 - 0.023 14.2 1.0 0.023 14.2 1.0 1.9 2 0 0 2 2 2 0 PHD-finger zf-HC5HC2H_2 PF13832.6 EMC83711.1 - 0.04 14.1 0.1 0.14 12.3 0.1 1.9 1 0 0 1 1 1 0 PHD-zinc-finger like domain ASRT PF07100.11 EMC83711.1 - 0.095 12.8 0.2 2.3 8.3 0.1 2.4 2 0 0 2 2 2 0 Anabaena sensory rhodopsin transducer DUF1664 PF07889.12 EMC83711.1 - 0.21 11.6 10.8 0.025 14.6 3.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) zf-RING_2 PF13639.6 EMC83711.1 - 0.22 11.9 7.8 0.42 11.0 7.8 1.5 1 0 0 1 1 1 0 Ring finger domain Zf_RING PF16744.5 EMC83711.1 - 0.3 11.2 7.2 1.2 9.2 7.2 2.1 1 1 0 1 1 1 0 KIAA1045 RING finger C1_2 PF03107.16 EMC83711.1 - 0.45 10.9 4.2 0.17 12.2 1.4 1.7 2 0 0 2 2 1 0 C1 domain Zn_ribbon_17 PF17120.5 EMC83711.1 - 1.1 8.9 5.2 1.1 9.0 3.5 1.8 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 EMC83711.1 - 1.3 9.4 4.6 2.7 8.4 4.6 1.6 1 0 0 1 1 1 0 RING-like domain OmpH PF03938.14 EMC83711.1 - 1.6 9.1 26.7 0.061 13.7 4.9 2.6 3 0 0 3 3 2 0 Outer membrane protein (OmpH-like) Prok-RING_1 PF14446.6 EMC83711.1 - 2 8.4 6.7 1.8 8.6 3.0 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Seryl_tRNA_N PF02403.22 EMC83711.1 - 2.2 8.5 13.8 0.84 9.9 4.5 2.9 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain PhnA_Zn_Ribbon PF08274.12 EMC83711.1 - 5.5 7.0 6.0 6.3 6.8 0.2 2.4 2 0 0 2 2 2 0 PhnA Zinc-Ribbon ADK_lid PF05191.14 EMC83711.1 - 5.5 7.1 8.5 1.2 9.2 3.7 2.4 2 1 0 2 2 2 0 Adenylate kinase, active site lid DZR PF12773.7 EMC83711.1 - 5.7 7.0 7.2 1.9e+02 2.2 7.2 2.4 1 1 0 1 1 1 0 Double zinc ribbon zf-PHD-like PF15446.6 EMC83711.1 - 6.6 6.3 10.2 0.12 12.0 0.9 2.7 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain Pex16 PF08610.10 EMC83714.1 - 3.1e-66 223.8 3.7 3.4e-66 223.6 3.7 1.0 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) BESS PF02944.20 EMC83714.1 - 0.13 12.1 0.2 0.31 10.9 0.2 1.6 1 0 0 1 1 1 0 BESS motif DUF4733 PF15878.5 EMC83715.1 - 3.2e-16 59.6 0.6 3.6e-16 59.4 0.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4733) Tantalus PF15386.6 EMC83715.1 - 0.11 12.6 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 Drosophila Tantalus-like Sulfotransfer_1 PF00685.27 EMC83716.1 - 5.7e-58 196.5 0.0 7e-58 196.2 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC83716.1 - 8.6e-16 59.0 0.0 1e-10 42.3 0.0 2.3 2 0 0 2 2 2 2 Sulfotransferase family CUB PF00431.20 EMC83717.1 - 4.3e-62 207.3 0.1 1.2e-30 106.1 0.0 2.8 3 0 0 3 3 3 2 CUB domain Astacin PF01400.24 EMC83717.1 - 1.8e-56 190.8 0.0 2.6e-56 190.3 0.0 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) CUB_2 PF02408.20 EMC83717.1 - 0.41 10.4 3.8 1.1 9.0 0.1 2.7 3 0 0 3 3 3 0 CUB-like domain FYVE PF01363.21 EMC83718.1 - 0.0017 18.5 16.0 0.0017 18.5 16.0 2.7 2 0 0 2 2 2 1 FYVE zinc finger Tho2 PF11262.8 EMC83718.1 - 1.3 8.1 4.9 0.76 8.9 0.2 2.2 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 PP1_inhibitor PF05361.12 EMC83719.1 - 4.7e-17 62.3 3.3 7.4e-16 58.4 3.3 1.9 1 1 0 1 1 1 1 PKC-activated protein phosphatase-1 inhibitor Pep3_Vps18 PF05131.14 EMC83720.1 - 2.1e-41 141.2 0.2 4.2e-40 137.0 0.0 2.4 2 0 0 2 2 2 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 EMC83720.1 - 3.1e-11 43.3 20.0 1.6e-09 37.8 3.8 3.0 3 1 0 3 3 2 2 Region in Clathrin and VPS zf-C3HC4_2 PF13923.6 EMC83720.1 - 0.0014 18.4 1.3 0.0014 18.4 1.3 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EMC83720.1 - 0.0019 17.8 0.1 0.0019 17.8 0.1 2.4 3 0 0 3 3 2 1 Zinc-ribbon, C4HC2 type Vps39_2 PF10367.9 EMC83720.1 - 0.0024 18.3 1.6 0.0047 17.3 0.4 2.2 2 0 0 2 2 1 1 Vacuolar sorting protein 39 domain 2 zf-RING_5 PF14634.6 EMC83720.1 - 0.0065 16.4 0.3 0.028 14.4 0.3 2.1 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EMC83720.1 - 0.017 15.2 0.5 0.055 13.5 0.5 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_2 PF13639.6 EMC83720.1 - 0.021 15.1 0.5 0.021 15.1 0.5 2.7 2 0 0 2 2 2 0 Ring finger domain zf-RING_11 PF17123.5 EMC83720.1 - 0.025 14.3 0.9 0.025 14.3 0.9 2.6 2 0 0 2 2 1 0 RING-like zinc finger Taxilin PF09728.9 EMC83720.1 - 0.035 13.3 3.5 0.049 12.8 0.4 2.2 2 0 0 2 2 2 0 Myosin-like coiled-coil protein zf-ANAPC11 PF12861.7 EMC83720.1 - 0.036 14.1 0.2 0.13 12.4 0.2 1.9 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF5600 PF18150.1 EMC83720.1 - 0.04 14.5 0.1 0.28 11.8 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5600) Nup54_57_C PF18570.1 EMC83720.1 - 0.041 13.5 1.7 0.1 12.2 0.6 2.3 2 0 0 2 2 2 0 NUP57/Nup54 C-terminal domain zf-rbx1 PF12678.7 EMC83720.1 - 0.062 13.6 0.2 0.062 13.6 0.2 2.3 2 0 0 2 2 1 0 RING-H2 zinc finger domain DUF2229 PF09989.9 EMC83720.1 - 0.068 12.8 0.0 0.19 11.4 0.0 1.8 1 1 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) Dzip-like_N PF13815.6 EMC83720.1 - 0.07 13.1 1.2 7.7 6.5 0.2 2.6 2 0 0 2 2 2 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal DUF1664 PF07889.12 EMC83720.1 - 0.086 12.9 1.4 0.23 11.5 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) KNOX2 PF03791.13 EMC83720.1 - 1.2 8.7 4.8 0.3 10.6 0.3 2.4 3 0 0 3 3 2 0 KNOX2 domain BEX PF04538.12 EMC83720.1 - 2 9.0 4.6 6.6 7.3 0.8 2.4 1 1 1 2 2 2 0 Brain expressed X-linked like family Exonuc_VII_S PF02609.16 EMC83720.1 - 2.6 8.2 6.8 23 5.1 1.5 3.6 3 0 0 3 3 3 0 Exonuclease VII small subunit ChaC PF04752.12 EMC83721.1 - 1.8e-32 112.8 0.0 2.2e-32 112.6 0.0 1.0 1 0 0 1 1 1 1 ChaC-like protein SNF2_N PF00176.23 EMC83723.1 - 7.4e-69 232.1 0.6 1.6e-68 231.0 0.6 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.6 EMC83723.1 - 3.7e-48 163.3 22.9 3.7e-48 163.3 22.9 3.8 3 0 0 3 3 3 1 DNA-binding domain Helicase_C PF00271.31 EMC83723.1 - 5.1e-18 65.4 0.6 2.6e-17 63.2 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC83723.1 - 2.7e-08 34.0 4.5 6.6e-06 26.2 0.0 3.7 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EMC83723.1 - 1.7e-05 24.1 0.1 1.7e-05 24.1 0.1 3.7 5 0 0 5 5 5 1 Class II histone deacetylase complex subunits 2 and 3 POTRA PF07244.15 EMC83723.1 - 5.2 7.7 5.8 2.8 8.6 0.3 2.9 3 0 0 3 3 3 0 Surface antigen variable number repeat EF-hand_1 PF00036.32 EMC83724.1 - 1.3e-13 49.4 3.7 1.5e-06 27.3 0.4 2.8 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 EMC83724.1 - 2.6e-13 50.2 0.9 2.6e-13 50.2 0.9 1.7 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EMC83724.1 - 1.4e-11 43.4 2.1 4.6e-07 29.3 0.3 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 EMC83724.1 - 1e-06 28.5 2.0 2.4e-05 24.1 0.3 3.1 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EMC83724.1 - 7.2e-06 25.3 4.4 0.011 15.2 0.2 3.0 3 0 0 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.9 EMC83724.1 - 0.00045 20.5 0.1 0.00086 19.6 0.1 1.5 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region RST PF12174.8 EMC83724.1 - 0.0012 18.8 0.1 0.003 17.4 0.0 1.7 2 0 0 2 2 2 1 RCD1-SRO-TAF4 (RST) plant domain EF-hand_4 PF12763.7 EMC83724.1 - 0.056 13.4 1.5 1.5 8.8 0.2 2.1 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Yippee-Mis18 PF03226.14 EMC83725.1 - 2.1e-19 69.7 3.0 3.1e-19 69.1 3.0 1.3 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly OrfB_Zn_ribbon PF07282.11 EMC83725.1 - 0.26 11.3 2.9 0.8 9.7 0.2 2.3 2 0 0 2 2 2 0 Putative transposase DNA-binding domain NUSAP PF16006.5 EMC83726.1 - 3.2e-111 371.8 24.5 3.2e-111 371.8 24.5 2.0 2 0 0 2 2 2 1 Nucleolar and spindle-associated protein TRAUB PF08164.12 EMC83726.1 - 0.078 13.5 0.1 0.078 13.5 0.1 3.9 2 2 0 3 3 3 0 Apoptosis-antagonizing transcription factor, C-terminal Plus-3 PF03126.18 EMC83727.1 - 1.5e-36 125.3 0.1 1.5e-36 125.3 0.1 2.8 2 0 0 2 2 2 1 Plus-3 domain Sulfotransfer_2 PF03567.14 EMC83728.1 - 3.9e-44 151.5 4.6 4.6e-44 151.2 4.6 1.0 1 0 0 1 1 1 1 Sulfotransferase family Pkip-1 PF06878.11 EMC83728.1 - 0.0011 19.1 1.0 0.0063 16.6 0.3 2.1 2 0 0 2 2 2 1 Pkip-1 protein DIL PF01843.19 EMC83728.1 - 0.015 15.5 0.2 0.067 13.5 0.1 2.1 1 1 0 1 1 1 0 DIL domain Pkinase_Tyr PF07714.17 EMC83729.1 - 4.9e-86 288.2 0.0 6.6e-86 287.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC83729.1 - 4.6e-31 108.1 0.0 6.7e-31 107.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain MAM PF00629.23 EMC83729.1 - 9.4e-22 77.6 0.1 2.8e-21 76.1 0.0 1.8 2 0 0 2 2 2 1 MAM domain, meprin/A5/mu Gly_rich PF12810.7 EMC83729.1 - 3.7e-21 76.2 24.5 6.4e-21 75.4 24.5 1.2 1 0 0 1 1 1 1 Glycine rich protein RPAP1_C PF08620.10 EMC83730.1 - 2.5e-27 94.8 0.6 6.6e-27 93.4 0.6 1.8 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 EMC83730.1 - 1.3e-16 60.1 3.9 3.7e-16 58.6 3.9 1.9 1 0 0 1 1 1 1 RPAP1-like, N-terminal TMEM151 PF14857.6 EMC83731.1 - 6e-212 704.2 17.5 7.4e-212 703.9 17.5 1.1 1 0 0 1 1 1 1 TMEM151 family Pkinase_Tyr PF07714.17 EMC83732.1 - 1.6e-85 286.5 0.0 2.2e-85 286.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC83732.1 - 8.2e-36 123.7 0.0 1.2e-35 123.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 EMC83732.1 - 3e-19 69.4 0.3 2.3e-11 44.1 0.0 2.8 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 EMC83732.1 - 6.8e-18 64.5 1.7 2.9e-15 56.1 0.1 2.8 2 1 0 2 2 2 2 Immunoglobulin I-set domain fn3 PF00041.21 EMC83732.1 - 1.8e-16 60.2 0.7 1.3e-10 41.5 0.5 2.6 2 0 0 2 2 2 2 Fibronectin type III domain Ig_2 PF13895.6 EMC83732.1 - 1.3e-14 54.2 0.1 3.9e-10 39.9 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 EMC83732.1 - 6.5e-12 45.5 0.3 2.3e-09 37.3 0.0 3.1 2 1 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 EMC83732.1 - 1.8e-05 24.8 0.0 0.0034 17.5 0.0 2.7 1 1 0 1 1 1 1 Immunoglobulin V-set domain Kinase-like PF14531.6 EMC83732.1 - 0.2 10.9 0.0 0.36 10.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like WD40 PF00400.32 EMC83733.1 - 2.1e-40 135.9 21.2 0.0011 19.8 0.3 12.7 12 0 0 12 12 12 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC83733.1 - 8.1e-15 54.9 0.2 0.0019 18.4 0.0 7.2 7 1 1 8 8 8 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC83733.1 - 7e-06 26.1 0.1 0.00027 20.9 0.0 3.1 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EMC83733.1 - 0.011 15.1 2.3 1.6 8.0 0.1 3.9 4 0 0 4 4 4 0 WD40-like domain Cytochrom_D1 PF02239.16 EMC83733.1 - 0.36 9.3 2.7 1.9 6.9 0.2 3.0 3 1 0 3 3 3 0 Cytochrome D1 heme domain Bunya_NS-S PF01104.17 EMC83734.1 - 0.09 12.6 0.3 0.14 12.0 0.3 1.3 1 0 0 1 1 1 0 Bunyavirus non-structural protein NS-s PLA2_B PF01735.18 EMC83735.1 - 2e-27 95.8 0.0 2.7e-27 95.4 0.0 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain cPLA2_C2 PF18695.1 EMC83735.1 - 5.5e-18 65.0 0.2 1.4e-17 63.6 0.1 1.8 1 1 0 1 1 1 1 Cytosolic phospholipases A2 C2-domain DUF4061 PF13270.6 EMC83735.1 - 0.44 10.9 2.8 0.35 11.2 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4061) PLA2_B PF01735.18 EMC83736.1 - 1.7e-34 119.1 0.0 6.2e-31 107.3 0.0 2.3 2 0 0 2 2 2 2 Lysophospholipase catalytic domain cPLA2_C2 PF18695.1 EMC83736.1 - 1.8e-23 82.7 3.4 1.7e-22 79.5 0.1 2.8 3 0 0 3 3 3 1 Cytosolic phospholipases A2 C2-domain C2 PF00168.30 EMC83736.1 - 7.7e-18 64.7 0.1 1.7e-17 63.6 0.1 1.6 1 0 0 1 1 1 1 C2 domain PLA2_B PF01735.18 EMC83737.1 - 5e-34 117.6 0.0 5.6e-32 110.8 0.0 2.7 2 1 1 3 3 3 2 Lysophospholipase catalytic domain cPLA2_C2 PF18695.1 EMC83737.1 - 3.1e-27 94.8 0.0 7e-27 93.6 0.0 1.6 1 0 0 1 1 1 1 Cytosolic phospholipases A2 C2-domain C2 PF00168.30 EMC83737.1 - 7.4e-17 61.5 0.0 1.8e-16 60.3 0.0 1.7 1 0 0 1 1 1 1 C2 domain CEP76-C2 PF15627.6 EMC83737.1 - 0.017 14.7 0.2 0.36 10.4 0.0 2.4 2 0 0 2 2 2 0 CEP76 C2 domain PLA2_B PF01735.18 EMC83738.1 - 9.1e-30 103.5 0.0 3.3e-28 98.4 0.0 2.3 2 1 0 2 2 2 2 Lysophospholipase catalytic domain C2 PF00168.30 EMC83738.1 - 2.4e-13 50.3 1.3 3.5e-13 49.7 0.2 1.8 2 0 0 2 2 2 1 C2 domain cPLA2_C2 PF18695.1 EMC83738.1 - 1.9e-12 47.2 0.4 4.1e-11 42.8 0.0 2.9 2 2 0 2 2 2 1 Cytosolic phospholipases A2 C2-domain DUF775 PF05603.12 EMC83738.1 - 0.066 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF775) PLA2_B PF01735.18 EMC83739.1 - 5.6e-26 91.0 0.1 3.1e-25 88.6 0.1 2.1 1 1 0 1 1 1 1 Lysophospholipase catalytic domain cPLA2_C2 PF18695.1 EMC83739.1 - 3.9e-25 88.0 0.3 2.3e-24 85.5 0.0 2.1 2 0 0 2 2 2 1 Cytosolic phospholipases A2 C2-domain C2 PF00168.30 EMC83739.1 - 7.8e-16 58.3 0.4 1.7e-15 57.2 0.4 1.6 1 0 0 1 1 1 1 C2 domain CEP76-C2 PF15627.6 EMC83739.1 - 0.12 11.9 0.1 0.43 10.1 0.1 1.9 2 0 0 2 2 2 0 CEP76 C2 domain C2 PF00168.30 EMC83740.1 - 3e-19 69.2 0.9 6.7e-19 68.1 0.4 1.7 1 1 1 2 2 2 1 C2 domain PhnH PF05845.12 EMC83740.1 - 0.031 14.0 0.0 0.034 13.9 0.0 1.1 1 0 0 1 1 1 0 Bacterial phosphonate metabolism protein (PhnH) PLA2_B PF01735.18 EMC83741.1 - 7.3e-30 103.8 0.1 8.5e-29 100.3 0.0 2.2 2 1 0 2 2 2 1 Lysophospholipase catalytic domain cPLA2_C2 PF18695.1 EMC83741.1 - 3.2e-24 85.1 0.7 1e-23 83.4 0.1 2.1 2 0 0 2 2 2 1 Cytosolic phospholipases A2 C2-domain C2 PF00168.30 EMC83741.1 - 6.3e-20 71.4 1.4 7.3e-20 71.2 0.3 1.7 2 0 0 2 2 2 1 C2 domain PLA2_B PF01735.18 EMC83742.1 - 8.4e-41 139.9 0.1 7e-34 117.1 0.0 2.9 2 1 1 3 3 3 3 Lysophospholipase catalytic domain cPLA2_C2 PF18695.1 EMC83742.1 - 2.6e-25 88.6 0.1 4.3e-25 87.9 0.1 1.4 1 0 0 1 1 1 1 Cytosolic phospholipases A2 C2-domain C2 PF00168.30 EMC83742.1 - 2.1e-17 63.3 0.1 4.4e-16 59.0 0.0 2.4 2 0 0 2 2 2 1 C2 domain Vps39_1 PF10366.9 EMC83743.1 - 6.6e-33 113.2 3.1 6.6e-33 113.2 3.1 3.3 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 EMC83743.1 - 2.1e-31 108.6 4.8 2.1e-31 108.6 4.8 2.8 4 0 0 4 4 4 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 EMC83743.1 - 8.1e-30 104.4 0.1 1.8e-29 103.2 0.1 1.6 1 0 0 1 1 1 1 CNH domain Clathrin PF00637.20 EMC83743.1 - 1.2e-11 44.6 12.5 1.1e-06 28.6 1.0 4.3 3 1 0 3 3 3 2 Region in Clathrin and VPS Lung_7-TM_R PF06814.13 EMC83744.1 - 7.2e-78 261.8 21.8 8.7e-78 261.5 21.8 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor SPT6_acidic PF14632.6 EMC83744.1 - 0.054 14.1 1.4 0.12 13.0 1.4 1.4 1 0 0 1 1 1 0 Acidic N-terminal SPT6 Glyco_hydro_31 PF01055.26 EMC83745.1 - 8.3e-145 483.3 1.3 1.3e-144 482.7 1.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EMC83745.1 - 5.3e-18 65.1 0.1 2.7e-17 62.8 0.0 2.4 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 EMC83745.1 - 0.00069 19.8 0.2 0.0018 18.5 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) NtCtMGAM_N PF16863.5 EMC83745.1 - 0.0013 18.9 0.0 0.0032 17.7 0.0 1.6 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase POC3_POC4 PF10448.9 EMC83745.1 - 0.024 14.7 0.0 0.17 11.9 0.0 2.2 2 0 0 2 2 2 0 20S proteasome chaperone assembly proteins 3 and 4 Peptidase_C2 PF00648.21 EMC83746.1 - 5.3e-139 462.3 0.2 7.5e-139 461.8 0.2 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 EMC83746.1 - 7.3e-53 178.6 0.0 1.6e-52 177.5 0.0 1.6 1 0 0 1 1 1 1 Calpain large subunit, domain III Calpain_u2 PF16648.5 EMC83746.1 - 4.5e-24 84.7 5.3 9.3e-24 83.7 5.3 1.6 1 0 0 1 1 1 1 Unstructured region on Calpain-3 EF-hand_1 PF00036.32 EMC83746.1 - 6.4e-18 62.9 11.9 2.8e-07 29.6 0.1 5.9 6 0 0 6 6 6 3 EF hand EF-hand_6 PF13405.6 EMC83746.1 - 4.7e-16 57.3 8.2 0.00013 21.6 0.0 5.6 6 0 0 6 6 6 4 EF-hand domain EF-hand_8 PF13833.6 EMC83746.1 - 1.7e-12 47.0 10.7 6.9e-10 38.6 0.6 4.7 4 1 0 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 EMC83746.1 - 5.1e-11 41.5 5.6 0.0014 18.0 0.0 4.6 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 EMC83746.1 - 7.1e-11 42.4 8.9 0.00017 22.0 0.4 4.5 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.7 EMC83746.1 - 0.022 14.7 3.3 1.2 9.1 0.3 2.7 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Ndufs5 PF10200.9 EMC83746.1 - 0.62 10.4 3.1 1.5 9.2 0.0 2.8 3 0 0 3 3 3 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa K_channel_TID PF07941.11 EMC83746.1 - 3.7 8.1 5.3 3.2 8.3 2.7 2.1 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain WD40 PF00400.32 EMC83747.1 - 7.2e-18 64.6 5.7 0.017 16.0 0.1 6.9 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC83747.1 - 3e-06 27.4 2.4 0.82 10.0 0.0 5.1 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain zf-met PF12874.7 EMC83747.1 - 0.0009 19.6 7.7 0.11 13.0 1.6 3.1 2 0 0 2 2 2 2 Zinc-finger of C2H2 type PQQ_3 PF13570.6 EMC83747.1 - 0.0014 19.1 1.9 62 4.3 0.0 5.5 6 0 0 6 6 6 0 PQQ-like domain zf-C2H2_jaz PF12171.8 EMC83747.1 - 0.0041 17.4 7.1 0.36 11.2 2.3 2.9 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_aberr PF17017.5 EMC83747.1 - 0.0099 16.0 0.3 0.0099 16.0 0.3 2.5 2 0 0 2 2 2 1 Aberrant zinc-finger WD40_like PF17005.5 EMC83747.1 - 0.026 13.9 2.7 0.19 11.0 0.2 2.1 2 0 0 2 2 2 0 WD40-like domain AKAP95 PF04988.12 EMC83747.1 - 0.58 10.4 12.3 4.9 7.4 1.5 2.7 1 1 1 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_2 PF12756.7 EMC83747.1 - 1.7 9.0 20.0 0.99 9.8 4.3 3.8 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) FOXP-CC PF16159.5 EMC83747.1 - 3.7 8.2 12.1 0.76 10.4 3.9 3.5 2 1 1 3 3 3 0 FOXP coiled-coil domain SNAP-25 PF00835.19 EMC83748.1 - 4.7e-22 78.0 0.4 9e-22 77.1 0.4 1.5 1 0 0 1 1 1 1 SNAP-25 family DUF5089 PF17002.5 EMC83748.1 - 8.6e-07 29.0 4.9 2.1e-06 27.8 4.9 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF5089) V-SNARE_C PF12352.8 EMC83748.1 - 0.00019 21.7 4.6 0.017 15.4 1.2 2.6 2 1 0 2 2 2 2 Snare region anchored in the vesicle membrane C-terminus DUF16 PF01519.16 EMC83748.1 - 0.0023 18.4 6.2 0.058 13.9 0.2 2.2 2 0 0 2 2 2 2 Protein of unknown function DUF16 SNARE PF05739.19 EMC83748.1 - 0.053 13.5 0.4 1.8 8.6 0.0 2.8 2 0 0 2 2 2 0 SNARE domain SOAR PF16533.5 EMC83748.1 - 0.076 13.0 1.8 0.5 10.4 0.1 2.6 2 1 0 2 2 2 0 STIM1 Orai1-activating region Sec20 PF03908.13 EMC83748.1 - 0.18 11.8 2.7 0.14 12.1 0.7 1.8 2 0 0 2 2 2 0 Sec20 DUF1664 PF07889.12 EMC83748.1 - 0.3 11.1 8.0 0.43 10.6 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) TolA_bind_tri PF16331.5 EMC83748.1 - 1.1 9.4 7.9 0.13 12.4 1.8 2.2 2 0 0 2 2 2 0 TolA binding protein trimerisation DUF948 PF06103.11 EMC83748.1 - 1.1 9.6 3.4 9.6 6.6 0.1 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) COG6 PF06419.11 EMC83748.1 - 1.5 7.0 7.5 4.4 5.4 0.6 2.1 2 0 0 2 2 2 0 Conserved oligomeric complex COG6 DUF4200 PF13863.6 EMC83748.1 - 1.5 9.2 7.4 7.6 7.0 1.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) XhlA PF10779.9 EMC83748.1 - 6.6 7.0 16.5 4.4 7.6 1.4 2.8 3 0 0 3 3 3 0 Haemolysin XhlA LRR_8 PF13855.6 EMC83749.1 - 1.5e-31 108.0 45.4 8.3e-12 44.7 7.1 4.1 1 1 5 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 EMC83749.1 - 1.8e-22 79.0 23.9 5.2e-07 29.9 2.1 4.6 5 0 0 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC83749.1 - 1.2e-08 34.3 24.8 0.17 12.5 0.3 7.7 6 1 0 6 6 6 3 Leucine Rich Repeat LRR_9 PF14580.6 EMC83749.1 - 1.8e-08 34.1 9.7 1.3e-05 24.8 1.9 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 EMC83749.1 - 6e-05 22.8 26.5 3 8.1 0.1 7.5 7 0 0 7 7 7 4 Leucine Rich repeat RsmF_methylt_CI PF17126.5 EMC83749.1 - 0.0021 18.1 0.2 1.9 8.6 0.1 4.0 3 1 2 5 5 5 1 RsmF rRNA methyltransferase first C-terminal domain HAUS2 PF15003.6 EMC83750.1 - 4.1e-31 108.2 2.6 5.3e-31 107.8 2.6 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 2 L27 PF02828.16 EMC83750.1 - 0.019 14.7 0.0 0.054 13.3 0.0 1.7 1 0 0 1 1 1 0 L27 domain DASH_Dad1 PF08649.10 EMC83750.1 - 0.41 10.9 5.8 4.7 7.5 0.5 3.3 3 1 1 4 4 4 0 DASH complex subunit Dad1 Kinesin PF00225.23 EMC83751.1 - 1e-100 336.9 0.1 1e-100 336.9 0.1 2.4 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EMC83751.1 - 9.7e-25 87.2 1.0 1.5e-23 83.4 0.0 2.9 2 1 0 2 2 2 1 Microtubule binding FHA PF00498.26 EMC83751.1 - 1.3e-06 28.7 1.6 3.9e-06 27.1 0.2 2.6 2 0 0 2 2 2 1 FHA domain Kinesin_assoc PF16183.5 EMC83751.1 - 2.8e-06 27.6 11.5 3.7e-05 23.9 0.6 4.2 2 2 2 4 4 4 2 Kinesin-associated Yop-YscD_cpl PF16697.5 EMC83751.1 - 9.5e-05 22.7 0.0 0.00045 20.5 0.0 2.2 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain START PF01852.19 EMC83752.1 - 1.2e-09 37.9 0.0 2.4e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 START domain Tetraspanin PF00335.20 EMC83753.1 - 1.3e-27 97.0 11.9 1.7e-27 96.7 11.9 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF1218 PF06749.12 EMC83753.1 - 0.088 13.3 2.1 4.9 7.7 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) Alfin PF12165.8 EMC83753.1 - 0.092 12.4 0.1 5.1 6.8 0.0 2.3 2 0 0 2 2 2 0 Alfin ArfGap PF01412.18 EMC83753.1 - 0.74 9.9 4.4 0.78 9.8 3.1 1.6 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf Metallophos PF00149.28 EMC83754.1 - 1.2e-10 42.2 0.1 2.3e-10 41.3 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Big_7 PF17957.1 EMC83754.1 - 0.00012 22.7 0.4 0.00057 20.6 0.0 2.2 2 0 0 2 2 2 1 Bacterial Ig domain ADH_N_2 PF16884.5 EMC83755.1 - 1.1e-26 92.8 0.0 2.2e-26 91.9 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 EMC83755.1 - 7.7e-15 56.1 0.0 1.6e-14 55.1 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EMC83755.1 - 1.3e-14 54.3 0.0 2.2e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Orthopox_F14 PF06076.12 EMC83755.1 - 0.033 14.4 0.0 0.061 13.6 0.0 1.4 1 0 0 1 1 1 0 Orthopoxvirus F14 protein ELM2 PF01448.24 EMC83756.1 - 2e-10 41.3 2.5 4.8e-10 40.0 0.0 2.5 2 0 0 2 2 2 1 ELM2 domain Myb_DNA-binding PF00249.31 EMC83756.1 - 0.00072 19.7 0.0 0.0016 18.6 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EMC83756.1 - 6.8 6.7 7.2 0.46 10.4 0.3 2.6 2 0 0 2 2 2 0 Myb DNA-binding like LRR_4 PF12799.7 EMC83758.1 - 4.8e-14 52.3 11.7 2.4e-05 24.6 0.0 3.5 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC83758.1 - 6.1e-08 32.4 2.7 0.00011 21.8 0.1 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 EMC83758.1 - 6.7e-08 32.2 9.3 0.0022 17.7 4.0 3.6 3 2 1 4 4 4 3 Leucine rich repeat Glyco_hydro_49 PF03718.13 EMC83758.1 - 0.045 13.8 0.8 0.12 12.3 0.2 1.9 2 0 0 2 2 2 0 Glycosyl hydrolase family 49 LRR_6 PF13516.6 EMC83758.1 - 0.73 10.0 4.7 11 6.4 0.8 3.9 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.33 EMC83758.1 - 1.5 9.6 13.6 52 5.0 0.0 4.7 5 0 0 5 5 5 0 Leucine Rich Repeat BAAT_C PF08840.11 EMC83759.1 - 1.5e-81 273.4 0.0 1.8e-81 273.1 0.0 1.1 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Bile_Hydr_Trans PF04775.14 EMC83759.1 - 1.2e-21 77.1 0.0 1.7e-21 76.6 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA thioester hydrolase/BAAT N-terminal region Peptidase_S9 PF00326.21 EMC83759.1 - 3.8e-05 23.3 0.0 0.00092 18.7 0.0 2.7 2 1 0 2 2 2 1 Prolyl oligopeptidase family FSH1 PF03959.13 EMC83759.1 - 6.5e-05 22.7 0.0 0.00011 22.0 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 EMC83759.1 - 8.3e-05 22.2 0.3 1 8.9 0.0 3.1 2 2 0 2 2 2 2 Dienelactone hydrolase family Chlorophyllase2 PF12740.7 EMC83759.1 - 0.14 11.0 0.0 0.22 10.4 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Cupin_4 PF08007.12 EMC83760.1 - 2.1e-58 198.3 0.0 2.9e-58 197.8 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 EMC83760.1 - 5.2e-06 26.4 0.0 0.00038 20.2 0.0 2.2 1 1 0 1 1 1 1 Cupin-like domain Cupin_2 PF07883.11 EMC83760.1 - 0.0084 15.8 0.0 0.73 9.6 0.0 2.4 2 0 0 2 2 2 2 Cupin domain PID PF00640.23 EMC83761.1 - 9.2e-35 119.7 0.1 1.5e-34 119.0 0.1 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) NumbF PF06311.12 EMC83761.1 - 3.9e-31 107.5 1.7 4.3e-30 104.1 0.8 2.8 2 0 0 2 2 2 1 NUMB domain PTB PF08416.13 EMC83761.1 - 1.4e-05 25.3 0.0 2.5e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID_2 PF14719.6 EMC83761.1 - 3e-05 23.9 0.1 6.1e-05 23.0 0.1 1.5 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) I-set PF07679.16 EMC83762.1 - 2e-44 149.6 0.0 5.5e-15 55.2 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC83762.1 - 7.5e-44 148.2 0.5 2.7e-13 50.3 0.0 4.0 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 EMC83762.1 - 3.6e-34 116.8 0.5 6e-11 42.4 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 EMC83762.1 - 7.3e-34 116.0 0.2 2.3e-10 40.6 0.0 3.8 3 0 0 3 3 3 3 Immunoglobulin domain ADAM_spacer1 PF05986.14 EMC83762.1 - 9.8e-34 115.8 0.0 1.6e-33 115.1 0.0 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 EMC83762.1 - 5.2e-29 100.2 73.2 4.6e-08 33.1 13.1 6.3 5 0 0 5 5 5 5 Thrombospondin type 1 domain V-set PF07686.17 EMC83762.1 - 1.5e-22 79.9 7.0 0.00012 22.2 0.1 6.6 3 3 2 5 5 5 5 Immunoglobulin V-set domain Kunitz_BPTI PF00014.23 EMC83762.1 - 2.9e-17 62.6 5.9 2.9e-17 62.6 5.9 3.3 2 0 0 2 2 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain PLAC PF08686.11 EMC83762.1 - 3e-09 37.5 8.8 3e-09 37.5 8.8 2.7 2 0 0 2 2 1 1 PLAC (protease and lacunin) domain Ig_4 PF16680.5 EMC83762.1 - 4.3e-07 30.1 0.0 0.69 10.2 0.0 3.7 3 0 0 3 3 3 3 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 EMC83762.1 - 1.4e-06 27.8 0.0 0.2 11.3 0.0 3.7 3 0 0 3 3 3 2 Immunoglobulin domain Izumo-Ig PF16706.5 EMC83762.1 - 1.3e-05 25.2 0.0 0.03 14.4 0.0 3.4 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain V-set_CD47 PF08204.11 EMC83762.1 - 0.00047 20.1 0.0 0.15 12.1 0.0 3.0 3 0 0 3 3 3 1 CD47 immunoglobulin-like domain C2-set PF05790.15 EMC83762.1 - 0.0024 18.0 0.0 5.7 7.2 0.0 3.8 4 0 0 4 4 4 1 Immunoglobulin C2-set domain Presenilin PF01080.17 EMC83763.1 - 1.1e-169 564.4 9.0 1.1e-169 564.4 9.0 2.0 2 0 0 2 2 2 1 Presenilin VIT1 PF01988.19 EMC83763.1 - 0.097 12.5 0.0 6.7 6.5 0.0 2.4 2 0 0 2 2 2 0 VIT family LRRC37AB_C PF14914.6 EMC83763.1 - 4.9 7.1 11.0 0.99 9.3 0.1 2.7 3 0 0 3 3 3 0 LRRC37A/B like protein 1 C-terminal domain FYVE PF01363.21 EMC83764.1 - 3.2e-23 81.7 20.7 3.3e-16 59.2 6.1 5.5 5 1 1 6 6 6 2 FYVE zinc finger AIG1 PF04548.16 EMC83764.1 - 0.002 17.5 0.0 0.004 16.5 0.0 1.5 1 0 0 1 1 1 1 AIG1 family GBP PF02263.19 EMC83764.1 - 0.0031 16.8 0.0 0.0055 16.0 0.0 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain ANAPC4_WD40 PF12894.7 EMC83765.1 - 0.0021 18.3 0.0 0.026 14.8 0.1 2.5 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EMC83765.1 - 0.0065 17.3 0.1 9.8 7.2 0.0 3.6 4 0 0 4 4 4 2 WD domain, G-beta repeat Nup160 PF11715.8 EMC83765.1 - 0.031 12.9 0.0 0.2 10.2 0.0 1.9 1 1 1 2 2 2 0 Nucleoporin Nup120/160 RGS_DHEX PF18148.1 EMC83767.1 - 1.9e-50 169.1 1.8 6.8e-50 167.3 1.8 2.0 1 0 0 1 1 1 1 Regulator of G-protein signalling DHEX domain RGS PF00615.19 EMC83767.1 - 2.2e-22 79.6 2.7 2.8e-22 79.2 0.0 2.3 2 1 0 2 2 2 1 Regulator of G protein signaling domain DEP PF00610.21 EMC83767.1 - 3.7e-17 62.2 0.0 9.3e-17 60.9 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) G-gamma PF00631.22 EMC83767.1 - 3e-12 46.4 0.1 7.5e-12 45.1 0.1 1.7 1 0 0 1 1 1 1 GGL domain RGS-like PF09128.11 EMC83767.1 - 0.027 14.2 0.1 0.13 12.0 0.0 2.0 2 0 0 2 2 2 0 Regulator of G protein signalling-like domain Ribosomal_L25p PF01386.19 EMC83767.1 - 0.13 12.8 0.1 0.58 10.7 0.0 2.0 2 0 0 2 2 2 0 Ribosomal L25p family Pecanex_C PF05041.15 EMC83768.1 - 2.5e-119 396.9 0.0 3.7e-119 396.4 0.0 1.2 1 0 0 1 1 1 1 Pecanex protein (C-terminus) TPR_1 PF00515.28 EMC83769.1 - 1.1e-07 31.4 3.0 1e-06 28.3 0.3 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EMC83769.1 - 2.3e-07 30.4 2.3 1.5e-06 27.9 0.4 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMC83769.1 - 0.00012 22.5 0.4 0.00026 21.4 0.4 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC83769.1 - 0.00076 19.7 1.0 0.001 19.2 1.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EMC83769.1 - 0.0017 19.0 0.0 0.0023 18.6 0.0 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMC83769.1 - 0.0027 17.7 5.3 0.25 11.5 1.4 2.2 1 1 1 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.6 EMC83769.1 - 0.0034 17.6 0.1 0.0047 17.2 0.1 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 EMC83769.1 - 0.016 15.4 1.5 0.12 12.6 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EMC83769.1 - 0.017 15.9 0.0 0.044 14.6 0.0 1.7 1 1 1 2 2 2 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 EMC83769.1 - 0.035 14.1 1.0 0.043 13.8 1.0 1.2 1 0 0 1 1 1 0 Putative TPR-like repeat TPR_17 PF13431.6 EMC83769.1 - 0.042 14.2 0.2 0.087 13.2 0.2 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF1041 PF06292.17 EMC83769.1 - 0.044 14.2 0.3 0.046 14.1 0.3 1.3 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1041) TPR_19 PF14559.6 EMC83769.1 - 0.067 13.7 0.1 0.083 13.4 0.1 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat Med6 PF04934.14 EMC83770.1 - 3.3e-44 149.9 0.2 4.5e-44 149.5 0.2 1.2 1 0 0 1 1 1 1 MED6 mediator sub complex component Peptidase_M15 PF01427.17 EMC83770.1 - 0.0046 16.7 0.1 1.2 8.8 0.0 2.3 2 0 0 2 2 2 2 D-ala-D-ala dipeptidase SAM_decarbox PF01536.16 EMC83770.1 - 0.064 12.3 0.0 0.075 12.0 0.0 1.2 1 0 0 1 1 1 0 Adenosylmethionine decarboxylase Ten1_2 PF15490.6 EMC83770.1 - 0.14 11.9 0.0 0.2 11.3 0.0 1.4 1 1 0 1 1 1 0 Telomere-capping, CST complex subunit Reprolysin PF01421.19 EMC83771.1 - 8.4e-53 179.2 0.1 8.4e-53 179.2 0.1 2.2 3 0 0 3 3 2 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 EMC83771.1 - 5.9e-35 120.2 3.0 5.9e-35 120.2 3.0 4.3 5 1 0 5 5 4 1 ADAM cysteine-rich Pep_M12B_propep PF01562.19 EMC83771.1 - 1.4e-20 73.9 0.0 2.8e-20 73.0 0.0 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide Disintegrin PF00200.23 EMC83771.1 - 6.1e-19 68.6 24.1 6.1e-19 68.6 24.1 4.5 5 0 0 5 5 4 1 Disintegrin Reprolysin_5 PF13688.6 EMC83771.1 - 2.3e-17 63.8 0.1 5.9e-17 62.5 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EMC83771.1 - 3.2e-16 60.0 0.0 5.5e-16 59.2 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EMC83771.1 - 3.1e-09 36.8 0.0 6.3e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EMC83771.1 - 3.1e-09 37.0 0.9 1.4e-08 34.9 0.2 2.3 2 1 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 EMC83771.1 - 0.021 14.7 0.0 0.035 13.9 0.0 1.3 1 0 0 1 1 1 0 Matrixin ADAM_CR_2 PF17771.1 EMC83771.1 - 0.025 15.1 0.3 0.025 15.1 0.3 6.7 6 1 1 7 7 6 0 ADAM cysteine-rich domain Peptidase_M43 PF05572.13 EMC83771.1 - 0.056 13.4 0.9 0.13 12.1 0.9 1.6 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A PDZ PF00595.24 EMC83772.1 - 3.4e-20 72.2 0.2 5.2e-20 71.6 0.0 1.4 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 EMC83772.1 - 9.4e-10 38.2 0.0 1.3e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC83772.1 - 5.8e-08 32.9 0.0 6.9e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 PDZ domain Peptidase_C97 PF05903.14 EMC83773.1 - 1.2e-41 142.0 0.0 1.6e-41 141.6 0.0 1.1 1 0 0 1 1 1 1 PPPDE putative peptidase domain DUF3670 PF12419.8 EMC83773.1 - 0.22 11.4 0.0 0.61 9.9 0.0 1.6 2 0 0 2 2 2 0 SNF2 Helicase protein Calx-beta PF03160.14 EMC83775.1 - 2.2e-62 207.5 8.6 1.1e-30 105.7 0.2 2.8 3 0 0 3 3 3 2 Calx-beta domain Na_Ca_ex PF01699.24 EMC83775.1 - 8.8e-58 194.6 35.7 3.1e-33 114.9 13.2 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Na_Ca_ex_C PF16494.5 EMC83775.1 - 4.7e-54 182.2 5.3 1.1e-53 181.1 5.3 1.6 1 0 0 1 1 1 1 C-terminal extension of sodium/calcium exchanger domain Acyl_transf_3 PF01757.22 EMC83775.1 - 0.78 8.7 25.5 0.24 10.4 12.0 2.5 2 0 0 2 2 2 0 Acyltransferase family Thyroglobulin_1 PF00086.18 EMC83776.1 - 8.8e-28 95.8 13.7 4.4e-18 64.7 1.8 2.5 2 0 0 2 2 2 2 Thyroglobulin type-1 repeat Thyroglob_assoc PF16597.5 EMC83776.1 - 1.4e-26 92.6 1.0 2.8e-26 91.6 1.0 1.6 1 0 0 1 1 1 1 Thyroglobulin_1 repeat associated disordered domain SPARC_Ca_bdg PF10591.9 EMC83776.1 - 1.2e-10 41.7 0.2 1.9e-10 41.0 0.0 1.5 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_7 PF13499.6 EMC83776.1 - 8.5e-05 22.9 0.3 0.00019 21.8 0.1 1.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EMC83776.1 - 0.0029 17.4 0.1 0.64 10.1 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 EMC83776.1 - 0.01 15.3 0.0 1.3 8.8 0.0 2.3 2 0 0 2 2 2 0 EF hand EF-hand_5 PF13202.6 EMC83776.1 - 0.027 14.0 0.0 2 8.1 0.0 2.3 2 0 0 2 2 2 0 EF hand Defensin_beta PF00711.19 EMC83776.1 - 1.4 9.0 5.5 7.4 6.7 0.5 2.6 2 0 0 2 2 2 0 Beta defensin Laminin_EGF PF00053.24 EMC83776.1 - 8.7 6.6 9.4 3 8.0 0.7 2.9 3 0 0 3 3 3 0 Laminin EGF domain SBF PF01758.16 EMC83777.1 - 2e-39 135.3 19.8 2.7e-39 134.9 15.9 2.2 1 1 1 2 2 2 1 Sodium Bile acid symporter family Mem_trans PF03547.18 EMC83777.1 - 0.17 10.2 17.7 0.77 8.1 0.6 2.9 1 1 1 3 3 3 0 Membrane transport protein DUF1270 PF06900.11 EMC83777.1 - 3.8 8.0 8.2 0.3 11.5 0.4 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1270) RRM_1 PF00076.22 EMC83778.1 - 2.1e-31 107.6 0.1 2.5e-16 59.2 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EMC83778.1 - 4.6e-07 29.8 0.1 0.0011 19.0 0.0 2.3 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.6 EMC83778.1 - 0.00018 21.5 0.0 0.00075 19.4 0.0 1.9 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 EMC83778.1 - 0.0029 17.2 0.0 0.18 11.4 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMC83778.1 - 0.0035 17.2 0.0 2.4 8.1 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif DbpA PF03880.15 EMC83778.1 - 0.011 15.7 0.0 7.1 6.7 0.0 2.5 3 0 0 3 3 3 0 DbpA RNA binding domain DUF2202 PF09968.9 EMC83778.1 - 0.1 12.4 0.1 0.15 11.9 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein domain (DUF2202) ALMT PF11744.8 EMC83778.1 - 1.8 7.3 5.9 2.3 6.9 5.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Sushi PF00084.20 EMC83779.1 - 2.9e-07 31.0 6.3 4.8e-07 30.3 6.3 1.4 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) PH PF00169.29 EMC83780.1 - 1e-07 32.4 0.0 2.7e-07 31.1 0.0 1.8 1 0 0 1 1 1 1 PH domain ERM PF00769.19 EMC83780.1 - 0.0077 16.1 30.4 0.0077 16.1 30.4 2.6 2 1 1 3 3 3 1 Ezrin/radixin/moesin family Leu_zip PF15294.6 EMC83780.1 - 0.28 10.7 41.6 0.13 11.7 15.7 2.3 2 0 0 2 2 2 0 Leucine zipper Glyco_trans_1_2 PF13524.6 EMC83780.1 - 0.8 10.1 3.8 1.4 9.3 0.3 2.7 2 0 0 2 2 2 0 Glycosyl transferases group 1 Zip PF02535.22 EMC83781.1 - 3.1e-40 138.4 19.1 3.3e-29 102.2 12.2 2.1 1 1 1 2 2 2 2 ZIP Zinc transporter 7TM-7TMR_HD PF07698.11 EMC83781.1 - 1 9.1 12.2 0.15 11.8 5.0 2.5 2 0 0 2 2 2 0 7TM receptor with intracellular HD hydrolase DUF996 PF06195.13 EMC83781.1 - 6.5 7.0 10.6 0.67 10.2 3.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF996) ER PF01133.17 EMC83782.1 - 5.9e-46 154.5 0.2 6.7e-46 154.3 0.2 1.0 1 0 0 1 1 1 1 Enhancer of rudimentary BA14K PF07886.11 EMC83782.1 - 0.11 12.4 1.2 0.25 11.3 1.2 1.6 1 0 0 1 1 1 0 BA14K-like protein Glycos_transf_2 PF00535.26 EMC83783.1 - 2.6e-26 92.4 0.0 4.2e-26 91.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 EMC83783.1 - 3.3e-18 66.2 3.5 5.7e-18 65.4 3.5 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 EMC83783.1 - 2.5e-08 34.1 0.0 4e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EMC83783.1 - 8e-07 28.8 0.0 2.2e-06 27.4 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 EMC83783.1 - 8.9e-06 25.3 0.1 1.9e-05 24.3 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase DUF4897 PF16238.5 EMC83783.1 - 0.034 14.0 0.0 0.057 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4897) DUF4227 PF14004.6 EMC83783.1 - 0.089 12.8 0.4 0.16 11.9 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4227) DNA_pol_A_exo1 PF01612.20 EMC83784.1 - 3e-15 56.4 0.0 6.2e-15 55.3 0.0 1.5 1 1 0 1 1 1 1 3'-5' exonuclease Ribosomal_S14 PF00253.21 EMC83784.1 - 0.14 11.9 0.5 0.5 10.2 0.0 2.0 2 0 0 2 2 2 0 Ribosomal protein S14p/S29e WD40 PF00400.32 EMC83785.1 - 1.5e-12 47.8 10.4 0.0048 17.7 0.1 5.8 5 0 0 5 5 5 4 WD domain, G-beta repeat Frtz PF11768.8 EMC83785.1 - 0.061 11.6 0.0 0.093 11.0 0.0 1.1 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Spectrin PF00435.21 EMC83786.1 - 1.3e-74 247.4 25.4 1.1e-25 90.1 6.9 4.3 4 0 0 4 4 4 4 Spectrin repeat CH PF00307.31 EMC83786.1 - 2.2e-51 172.6 0.1 4.6e-26 91.1 0.0 3.0 3 0 0 3 3 2 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 EMC83786.1 - 9e-27 93.0 0.0 3.5e-26 91.1 0.0 2.1 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_1 PF00036.32 EMC83786.1 - 3.6e-10 38.7 0.0 2.4e-05 23.5 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EMC83786.1 - 2.4e-07 30.2 0.1 6.7e-05 22.5 0.0 3.8 3 0 0 3 3 3 1 EF-hand domain CAMSAP_CH PF11971.8 EMC83786.1 - 1.1e-06 28.3 0.0 6.4e-05 22.7 0.0 2.6 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_7 PF13499.6 EMC83786.1 - 1.3e-06 28.7 0.1 1.1e-05 25.8 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 EMC83786.1 - 3e-05 23.8 0.1 0.027 14.3 0.0 3.7 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 EMC83786.1 - 0.0057 16.1 0.0 0.044 13.3 0.0 2.5 2 0 0 2 2 2 1 EF hand XisI PF08869.11 EMC83786.1 - 0.0095 16.3 0.9 0.034 14.5 0.9 2.0 1 0 0 1 1 1 1 XisI protein Dak2 PF02734.17 EMC83786.1 - 0.078 12.9 0.5 9.4 6.1 0.1 3.0 3 0 0 3 3 3 0 DAK2 domain Uds1 PF15456.6 EMC83786.1 - 0.12 12.5 10.3 0.16 12.1 2.4 3.6 3 0 0 3 3 3 0 Up-regulated During Septation U3_assoc_6 PF08640.11 EMC83786.1 - 0.83 9.8 4.0 1.5 8.9 0.1 3.3 3 0 0 3 3 3 0 U3 small nucleolar RNA-associated protein 6 RRM_1 PF00076.22 EMC83787.1 - 4.4e-34 116.1 0.1 1.6e-16 59.9 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EMC83787.1 - 2.4e-08 34.0 0.3 1.1e-05 25.4 0.0 2.3 2 0 0 2 2 2 2 RNA binding motif RRM_5 PF13893.6 EMC83787.1 - 1.2e-05 24.9 0.0 0.048 13.3 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMC83787.1 - 4.8e-05 23.1 0.0 0.22 11.4 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EMC83787.1 - 0.0072 16.3 0.2 0.067 13.2 0.1 2.1 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif DbpA PF03880.15 EMC83787.1 - 0.027 14.5 0.1 4.1 7.5 0.0 2.4 2 0 0 2 2 2 0 DbpA RNA binding domain SET_assoc PF11767.8 EMC83787.1 - 0.096 12.3 0.2 1 9.1 0.1 2.3 3 0 0 3 3 3 0 Histone lysine methyltransferase SET associated Presenilin PF01080.17 EMC83787.1 - 1.6 7.4 8.6 2 7.1 8.6 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 EMC83787.1 - 3.5 5.8 14.9 4.1 5.6 14.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Rad51 PF08423.11 EMC83788.1 - 7.9e-39 133.4 0.0 9.3e-39 133.2 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 EMC83788.1 - 4.9e-11 42.6 0.0 6.4e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EMC83788.1 - 2.7e-07 30.2 0.6 1.4e-06 27.9 0.6 2.1 1 1 0 1 1 1 1 KaiC RecA PF00154.21 EMC83788.1 - 1.8e-05 24.3 0.1 0.025 14.1 0.0 2.1 2 0 0 2 2 2 2 recA bacterial DNA recombination protein DnaB_C PF03796.15 EMC83788.1 - 3.6e-05 23.2 0.1 0.0011 18.4 0.1 2.3 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain PAXNEB PF05625.11 EMC83788.1 - 0.022 13.9 0.1 0.035 13.2 0.1 1.2 1 0 0 1 1 1 0 PAXNEB protein AAA_24 PF13479.6 EMC83788.1 - 0.059 13.1 0.0 0.083 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EMC83788.1 - 0.11 12.9 0.0 0.49 10.8 0.0 2.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF5522 PF17653.1 EMC83788.1 - 0.13 12.2 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5522) SAM_2 PF07647.17 EMC83788.1 - 0.14 12.3 0.1 0.24 11.5 0.1 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) PDGF_N PF04692.13 EMC83788.1 - 0.15 12.9 0.3 0.68 10.8 0.1 2.2 2 1 0 2 2 2 0 Platelet-derived growth factor, N terminal region ABC_trans_CmpB PF06541.11 EMC83789.1 - 1.4e-09 38.4 11.6 1.8e-09 38.0 11.6 1.1 1 0 0 1 1 1 1 Putative ABC-transporter type IV PIG-H PF10181.9 EMC83790.1 - 2.9e-10 39.9 0.2 4e-10 39.4 0.2 1.3 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component Arginase PF00491.21 EMC83791.1 - 2.9e-66 223.8 0.0 3.3e-66 223.6 0.0 1.0 1 0 0 1 1 1 1 Arginase family zf-C2H2_assoc PF16606.5 EMC83791.1 - 0.12 12.6 0.4 12 6.1 0.0 2.3 2 0 0 2 2 2 0 Unstructured conserved, between two C2H2-type zinc-fingers Ubiq_cyt_C_chap PF03981.12 EMC83791.1 - 0.18 11.9 0.0 0.72 9.9 0.0 1.9 2 0 0 2 2 2 0 Ubiquinol-cytochrome C chaperone V-SNARE_C PF12352.8 EMC83792.1 - 6.5e-20 71.2 8.4 6.5e-20 71.2 8.4 2.4 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.15 EMC83792.1 - 6.6e-13 48.9 4.9 6.6e-13 48.9 4.9 2.2 2 1 1 3 3 3 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.13 EMC83792.1 - 2.6e-06 27.3 1.7 2.6e-06 27.3 1.7 1.9 2 1 0 2 2 2 1 Sec20 Fusion_gly PF00523.18 EMC83792.1 - 0.005 15.1 3.1 0.0074 14.6 3.1 1.3 1 1 0 1 1 1 1 Fusion glycoprotein F0 DUF4407 PF14362.6 EMC83792.1 - 0.0058 16.0 1.3 0.0077 15.6 1.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) YqjK PF13997.6 EMC83792.1 - 0.019 15.2 2.8 1.6 9.1 0.0 2.5 3 0 0 3 3 3 0 YqjK-like protein FAM184 PF15665.5 EMC83792.1 - 0.02 14.7 7.5 0.025 14.4 7.5 1.1 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B Laminin_II PF06009.12 EMC83792.1 - 0.046 13.7 3.1 0.18 11.8 0.4 2.3 2 1 0 2 2 2 0 Laminin Domain II Snapin_Pallidin PF14712.6 EMC83792.1 - 0.046 14.1 10.6 0.064 13.7 0.7 2.5 2 1 0 2 2 2 0 Snapin/Pallidin DUF745 PF05335.13 EMC83792.1 - 0.13 12.0 5.4 1.6 8.4 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF745) ETRAMP PF09716.10 EMC83792.1 - 0.15 12.2 0.0 0.19 11.8 0.0 1.4 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF3958 PF13125.6 EMC83792.1 - 0.3 11.3 10.6 0.068 13.4 2.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3958) Glutaredoxin2_C PF04399.13 EMC83792.1 - 0.36 10.7 2.3 1.4 8.8 0.2 2.4 2 1 1 3 3 3 0 Glutaredoxin 2, C terminal domain SNARE PF05739.19 EMC83792.1 - 0.45 10.6 3.1 0.98 9.5 0.7 2.3 2 0 0 2 2 2 0 SNARE domain HalX PF08663.10 EMC83792.1 - 0.79 10.1 7.9 5.3 7.4 1.7 2.4 2 0 0 2 2 2 0 HalX domain KxDL PF10241.9 EMC83792.1 - 2.3 8.5 9.7 4.4 7.6 1.1 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein UPF0242 PF06785.11 EMC83792.1 - 8.1 6.5 16.8 11 6.1 6.4 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Tho2 PF11262.8 EMC83792.1 - 9.6 5.3 9.9 2.6 7.2 3.1 2.6 2 1 1 3 3 3 0 Transcription factor/nuclear export subunit protein 2 FYVE PF01363.21 EMC83793.1 - 1e-15 57.6 15.7 1e-15 57.6 15.7 2.8 3 0 0 3 3 3 1 FYVE zinc finger TPR_2 PF07719.17 EMC83793.1 - 0.0021 18.0 1.3 0.026 14.6 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EMC83793.1 - 3.6 8.7 5.2 1.2e+02 3.9 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat SgrR_N PF12793.7 EMC83793.1 - 5.8 7.2 8.5 21 5.4 0.2 4.5 4 0 0 4 4 4 0 Sugar transport-related sRNA regulator N-term Gal-bind_lectin PF00337.22 EMC83794.1 - 3e-32 111.0 0.0 3.3e-32 110.8 0.0 1.0 1 0 0 1 1 1 1 Galactoside-binding lectin PH PF00169.29 EMC83795.1 - 7.5e-36 122.8 0.0 1.1e-17 64.4 0.1 2.4 2 0 0 2 2 2 2 PH domain DEP PF00610.21 EMC83795.1 - 7.9e-17 61.1 0.0 1.9e-16 59.8 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH_11 PF15413.6 EMC83795.1 - 6.9e-08 32.9 3.9 0.026 15.0 0.0 4.1 3 1 0 3 3 3 2 Pleckstrin homology domain PH_9 PF15410.6 EMC83795.1 - 1.3e-07 32.0 0.4 0.041 14.3 0.0 3.5 3 2 0 3 3 3 2 Pleckstrin homology domain PH_8 PF15409.6 EMC83795.1 - 0.00049 20.3 0.5 0.24 11.7 0.3 3.3 2 1 0 2 2 2 1 Pleckstrin homology domain PH_6 PF15406.6 EMC83795.1 - 0.0044 17.3 0.0 0.23 11.7 0.0 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH_2 PF08458.10 EMC83795.1 - 0.012 15.9 0.0 8.4 6.8 0.0 2.6 2 0 0 2 2 2 0 Plant pleckstrin homology-like region PH_4 PF15404.6 EMC83795.1 - 0.031 14.1 0.2 8.5 6.1 0.0 3.4 4 0 0 4 4 4 0 Pleckstrin homology domain EIF_2_alpha PF07541.12 EMC83796.1 - 1.1e-36 125.5 0.0 2.2e-36 124.5 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EMC83796.1 - 1.1e-15 57.7 0.7 2.7e-15 56.5 0.7 1.6 1 0 0 1 1 1 1 S1 RNA binding domain SoDot-IcmSS PF16848.5 EMC83796.1 - 0.058 13.4 0.5 0.22 11.5 0.1 2.1 2 0 0 2 2 2 0 Substrate of the Dot/Icm secretion system, putative DUF4453 PF14627.6 EMC83796.1 - 0.13 12.4 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4453) ATP-synt_D PF01813.17 EMC83797.1 - 3.1e-76 255.6 8.6 4.2e-76 255.2 8.6 1.2 1 0 0 1 1 1 1 ATP synthase subunit D DUF4249 PF14054.6 EMC83797.1 - 0.049 13.2 0.1 0.063 12.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4249) Guanylate_kin PF00625.21 EMC83798.1 - 4.8e-52 176.3 0.0 1.1e-51 175.1 0.0 1.6 1 0 0 1 1 1 1 Guanylate kinase L27_N PF09060.10 EMC83798.1 - 3.1e-25 88.0 3.3 9.4e-25 86.4 3.3 1.9 1 0 0 1 1 1 1 L27_N SH3_2 PF07653.17 EMC83798.1 - 2.1e-12 46.5 0.0 4.7e-12 45.4 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain PDZ PF00595.24 EMC83798.1 - 1.2e-11 44.8 0.6 2.4e-11 43.8 0.6 1.6 1 0 0 1 1 1 1 PDZ domain L27 PF02828.16 EMC83798.1 - 1.2e-09 37.8 3.7 1.6e-09 37.4 1.5 2.4 2 0 0 2 2 2 1 L27 domain PDZ_6 PF17820.1 EMC83798.1 - 2.4e-09 36.9 0.0 6.6e-09 35.5 0.0 1.8 1 0 0 1 1 1 1 PDZ domain SH3_1 PF00018.28 EMC83798.1 - 2e-06 27.3 0.3 7.1e-06 25.5 0.3 2.0 1 1 0 1 1 1 1 SH3 domain PDZ_2 PF13180.6 EMC83798.1 - 5.9e-06 26.5 0.1 1.7e-05 25.0 0.1 1.8 1 0 0 1 1 1 1 PDZ domain SH3_9 PF14604.6 EMC83798.1 - 0.0003 20.6 0.1 0.00067 19.5 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain MMR_HSR1 PF01926.23 EMC83798.1 - 0.024 14.7 0.0 0.16 12.1 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase SpoU_sub_bind PF08032.12 EMC83798.1 - 5.6 7.3 5.5 16 5.8 0.0 3.8 4 1 1 5 5 5 0 RNA 2'-O ribose methyltransferase substrate binding MoCF_biosynth PF00994.24 EMC83799.1 - 3e-67 224.7 0.0 3e-39 133.9 0.0 2.3 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.17 EMC83799.1 - 6.1e-42 143.1 1.4 1.2e-41 142.1 0.5 1.9 2 0 0 2 2 2 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.15 EMC83799.1 - 2.2e-23 82.2 0.0 5.8e-23 80.9 0.0 1.8 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) Tubulin-binding PF00418.19 EMC83799.1 - 0.18 11.9 0.1 0.38 10.8 0.1 1.5 1 0 0 1 1 1 0 Tau and MAP protein, tubulin-binding repeat BMF PF15185.6 EMC83800.1 - 1.7e-98 328.0 8.2 4.9e-98 326.5 8.2 1.6 1 1 0 1 1 1 1 Bcl-2-modifying factor, apoptosis SRP14 PF02290.15 EMC83801.1 - 9.9e-25 86.7 0.1 9.9e-25 86.7 0.1 1.5 2 0 0 2 2 2 1 Signal recognition particle 14kD protein DUF3509 PF12021.8 EMC83801.1 - 0.093 12.5 0.0 1.4 8.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3509) Pkinase PF00069.25 EMC83802.1 - 1.4e-78 263.9 12.2 6.2e-36 124.1 0.0 4.8 4 1 0 4 4 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EMC83802.1 - 1.7e-46 158.6 1.1 9.2e-19 67.7 0.2 5.2 3 2 0 3 3 3 3 Protein tyrosine kinase HGTP_anticodon2 PF12745.7 EMC83802.1 - 1.5e-17 64.0 0.4 1.5e-17 64.0 0.4 2.4 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs tRNA-synt_His PF13393.6 EMC83802.1 - 5.3e-15 55.5 0.0 5.3e-15 55.5 0.0 1.8 2 0 0 2 2 1 1 Histidyl-tRNA synthetase RWD PF05773.22 EMC83802.1 - 1.1e-13 51.4 1.3 3.1e-13 50.0 0.0 2.5 2 0 0 2 2 2 1 RWD domain Kinase-like PF14531.6 EMC83802.1 - 6.5e-07 29.0 0.1 0.068 12.5 0.0 3.3 3 0 0 3 3 3 2 Kinase-like Kdo PF06293.14 EMC83802.1 - 8.7e-05 22.0 0.4 0.068 12.5 0.1 2.5 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMC83802.1 - 0.043 13.7 0.1 0.043 13.7 0.1 2.4 3 0 0 3 3 2 0 Phosphotransferase enzyme family DUF1682 PF07946.14 EMC83802.1 - 0.93 8.6 20.6 1.9 7.7 20.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) CRA PF06589.11 EMC83802.1 - 1.7 8.8 6.4 7 6.8 6.4 2.1 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) Borrelia_P83 PF05262.11 EMC83802.1 - 2.6 6.5 13.5 4.2 5.8 13.5 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein 7tm_1 PF00001.21 EMC83803.1 - 2.4e-30 105.8 29.0 3.1e-30 105.4 29.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) FSIP1 PF15554.6 EMC83804.1 - 1.9e-25 89.8 4.9 2.6e-25 89.4 4.9 1.2 1 0 0 1 1 1 1 FSIP1 family Katanin_con80 PF13925.6 EMC83806.1 - 1.1e-31 110.0 0.1 1.8e-31 109.4 0.1 1.3 1 0 0 1 1 1 1 con80 domain of Katanin DUF2012 PF09430.10 EMC83807.1 - 5.3e-30 104.1 0.1 7e-30 103.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) Fibrinogen_C PF00147.18 EMC83808.1 - 5e-41 140.9 3.1 5.5e-41 140.8 3.1 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain 7tm_1 PF00001.21 EMC83809.1 - 2.8e-75 253.0 7.4 3.6e-75 252.7 7.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC83809.1 - 3.5e-08 33.4 7.4 3.5e-08 33.4 7.4 1.8 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 EMC83809.1 - 5.3e-06 26.0 3.8 5.3e-06 26.0 3.8 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC83809.1 - 0.00022 21.1 10.4 0.00025 20.9 1.4 2.5 2 1 0 2 2 2 2 Olfactory receptor FH2 PF02181.23 EMC83812.1 - 1.1e-97 327.5 6.2 1.1e-97 327.5 6.2 2.1 2 0 0 2 2 2 1 Formin Homology 2 Domain DAN PF03045.15 EMC83813.1 - 6.3e-38 129.3 6.0 8.8e-38 128.8 6.0 1.2 1 0 0 1 1 1 1 DAN domain LPAM_1 PF08139.12 EMC83813.1 - 0.19 12.3 0.5 0.19 12.3 0.5 1.9 2 0 0 2 2 2 0 Prokaryotic membrane lipoprotein lipid attachment site zf-C2HCIx2C PF10782.9 EMC83813.1 - 1.6 8.7 8.4 2.8 7.9 2.3 2.3 1 1 1 2 2 2 0 Zinc-finger Secretogranin_V PF05281.11 EMC83814.1 - 2.9e-12 46.7 0.6 1.9e-09 37.5 0.1 2.1 1 1 1 2 2 2 2 Neuroendocrine protein 7B2 precursor (Secretogranin V) RhoGAP PF00620.27 EMC83815.1 - 3.8e-30 104.7 0.1 8e-30 103.7 0.1 1.6 1 0 0 1 1 1 1 RhoGAP domain TPD PF14811.6 EMC83816.1 - 8.9e-37 126.0 1.9 2e-36 124.8 0.2 2.3 2 1 0 2 2 2 1 Protein of unknown function TPD sequence-motif CtsR PF05848.11 EMC83816.1 - 0.14 12.1 0.0 0.31 11.0 0.0 1.7 1 0 0 1 1 1 0 CtsR N-terminal HTH domain Diphthami_syn_2 PF01902.17 EMC83818.1 - 4.2e-41 140.8 0.1 9.1e-41 139.8 0.1 1.5 1 1 0 1 1 1 1 Diphthamide synthase GRDB PF07355.12 EMC83818.1 - 0.13 11.4 0.0 0.3 10.3 0.0 1.5 1 0 0 1 1 1 0 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) zf-C2H2 PF00096.26 EMC83819.1 - 4e-39 130.9 118.5 4.7e-05 23.6 2.1 13.5 13 0 0 13 13 13 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC83819.1 - 3.9e-28 95.7 113.2 0.00048 20.7 1.4 14.1 14 0 0 14 14 14 12 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC83819.1 - 2.3e-26 91.0 118.2 8.5e-08 32.3 1.2 13.6 15 0 0 15 15 15 10 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EMC83819.1 - 5.3e-09 36.1 71.4 0.13 12.6 0.2 13.3 13 0 0 13 13 13 7 Zinc-finger double-stranded RNA-binding BolA PF01722.18 EMC83819.1 - 9.2e-05 22.7 19.0 2.9 8.2 0.1 7.9 3 2 5 9 9 9 3 BolA-like protein zf-MYST PF17772.1 EMC83819.1 - 0.026 14.1 0.1 0.026 14.1 0.1 7.9 8 1 1 9 9 9 0 MYST family zinc finger domain FYDLN_acid PF09538.10 EMC83819.1 - 0.22 12.2 20.5 24 5.7 0.1 7.4 6 2 1 8 8 8 0 Protein of unknown function (FYDLN_acid) zf-met PF12874.7 EMC83819.1 - 1.6 9.3 79.9 0.31 11.5 0.6 12.7 13 0 0 13 13 13 0 Zinc-finger of C2H2 type Aquarius_N PF16399.5 EMC83820.1 - 0 1067.7 0.4 0 1067.0 0.4 1.2 1 0 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_12 PF13087.6 EMC83820.1 - 3.7e-26 92.0 1.3 1.2e-24 87.1 0.0 3.2 3 1 0 3 3 3 1 AAA domain AAA_11 PF13086.6 EMC83820.1 - 1.4e-24 87.3 0.5 3e-23 82.9 0.0 3.0 3 1 0 3 3 3 1 AAA domain AAA_19 PF13245.6 EMC83820.1 - 5.2e-07 30.1 0.0 9.6e-06 26.0 0.0 2.8 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 EMC83820.1 - 3.8e-05 23.7 0.0 0.00012 22.1 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EMC83820.1 - 0.0029 17.4 0.0 1.4 8.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain UvrD_C_2 PF13538.6 EMC83820.1 - 0.004 16.9 0.2 0.0084 15.9 0.2 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain DUF2075 PF09848.9 EMC83820.1 - 0.0085 15.4 0.1 0.15 11.3 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 EMC83820.1 - 0.0098 16.3 0.0 0.023 15.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) UvrD-helicase PF00580.21 EMC83820.1 - 0.03 13.8 0.0 0.29 10.6 0.0 2.4 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain DUF4088 PF13317.6 EMC83820.1 - 0.16 11.5 0.0 0.31 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4088) Astro_capsid_p PF12226.8 EMC83820.1 - 0.23 10.6 5.7 0.37 9.9 5.7 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Actin PF00022.19 EMC83821.1 - 2.9e-142 474.0 0.0 1e-141 472.3 0.0 1.7 1 1 0 1 1 1 1 Actin Connexin PF00029.19 EMC83822.1 - 9.1e-98 326.7 6.1 1.1e-97 326.4 6.1 1.1 1 0 0 1 1 1 1 Connexin DIRP PF06584.13 EMC83822.1 - 0.031 14.5 0.7 0.22 11.7 0.2 2.3 2 0 0 2 2 2 0 DIRP Sec3-PIP2_bind PF15277.6 EMC83823.1 - 4.1e-24 84.5 0.1 6.8e-24 83.8 0.1 1.4 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Synaptobrevin PF00957.21 EMC83823.1 - 2.4e-06 27.2 0.5 2.4e-06 27.2 0.5 1.8 2 0 0 2 2 2 1 Synaptobrevin Dynactin PF12455.8 EMC83823.1 - 0.042 13.1 0.9 0.087 12.1 0.3 1.7 2 0 0 2 2 2 0 Dynein associated protein DSX_dimer PF08828.10 EMC83823.1 - 0.046 13.4 0.2 1.1 9.0 0.1 2.3 2 0 0 2 2 2 0 Doublesex dimerisation domain KH_1 PF00013.29 EMC83824.1 - 5.7e-33 112.6 5.8 9.4e-17 60.6 0.8 3.0 3 0 0 3 3 3 2 KH domain KH_2 PF07650.17 EMC83824.1 - 4.6e-08 32.8 3.6 2.9e-05 23.8 0.2 2.4 2 0 0 2 2 2 2 KH domain KH_4 PF13083.6 EMC83824.1 - 8.6e-07 28.7 1.9 0.008 16.0 0.0 2.8 3 0 0 3 3 3 2 KH domain KH_5 PF13184.6 EMC83824.1 - 0.092 12.8 2.0 1.3 9.2 0.1 2.4 2 0 0 2 2 2 0 NusA-like KH domain Forkhead PF00250.18 EMC83826.1 - 9.8e-40 134.7 0.1 1.8e-39 133.9 0.1 1.5 1 0 0 1 1 1 1 Forkhead domain zf-HC5HC2H PF13771.6 EMC83827.1 - 1.7e-19 69.9 2.7 1.7e-19 69.9 2.7 4.0 2 1 1 3 3 3 1 PHD-like zinc-binding domain HECT PF00632.25 EMC83827.1 - 3.7e-10 39.8 0.1 6.2e-10 39.1 0.1 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) zf-HC5HC2H_2 PF13832.6 EMC83827.1 - 1.8e-07 31.3 5.2 1.8e-07 31.3 5.2 4.1 2 1 1 4 4 4 1 PHD-zinc-finger like domain Sec1 PF00995.23 EMC83828.1 - 2.4e-129 433.2 1.2 2.7e-129 433.1 1.2 1.0 1 0 0 1 1 1 1 Sec1 family cwf21 PF08312.12 EMC83828.1 - 0.094 12.9 0.1 0.6 10.3 0.0 2.4 2 0 0 2 2 2 0 cwf21 domain VWA PF00092.28 EMC83829.1 - 1e-81 273.4 0.1 6.2e-42 143.8 0.1 2.1 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 EMC83829.1 - 4.9e-27 94.7 0.0 4.2e-12 46.7 0.1 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain LCCL PF03815.19 EMC83829.1 - 2.8e-22 78.6 0.1 7.1e-22 77.3 0.0 1.8 2 0 0 2 2 2 1 LCCL domain VWA_3 PF13768.6 EMC83829.1 - 0.00042 20.3 0.0 0.52 10.2 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain Rxt3 PF08642.10 EMC83829.1 - 0.099 13.4 0.0 0.3 11.9 0.0 1.8 1 1 0 1 1 1 0 Histone deacetylation protein Rxt3 Clat_adaptor_s PF01217.20 EMC83830.1 - 2.5e-38 131.2 7.8 2.8e-38 131.1 7.8 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain PHD_like PF12910.7 EMC83830.1 - 0.018 15.1 0.8 0.024 14.6 0.8 1.2 1 0 0 1 1 1 0 Antitoxin of toxin-antitoxin, RelE / RelB, TA system HECT PF00632.25 EMC83831.1 - 3.5e-74 250.1 0.0 8e-74 248.9 0.0 1.6 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) BTHB PF18410.1 EMC83831.1 - 1.6e-27 95.1 0.1 3.3e-27 94.1 0.1 1.6 1 0 0 1 1 1 1 Basic tilted helix bundle domain Sad1_UNC PF07738.13 EMC83831.1 - 5e-24 84.8 0.0 9.9e-24 83.8 0.0 1.5 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal MIB_HERC2 PF06701.13 EMC83831.1 - 1.4e-23 82.9 2.7 3.3e-23 81.7 2.7 1.7 1 0 0 1 1 1 1 Mib_herc2 Ank_2 PF12796.7 EMC83831.1 - 1.5e-13 51.2 0.0 1.2e-08 35.4 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC83831.1 - 5e-11 42.6 0.0 8.9e-08 32.3 0.0 3.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC83831.1 - 4.2e-08 33.6 0.0 5.1e-06 26.9 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EMC83831.1 - 8.8e-08 32.3 0.0 0.00038 20.8 0.0 4.3 4 0 0 4 4 4 1 Ankyrin repeat Ank_3 PF13606.6 EMC83831.1 - 1.1e-07 31.5 0.0 0.12 13.0 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat F5_F8_type_C PF00754.25 EMC83831.1 - 9.1e-06 25.8 0.1 2.7e-05 24.3 0.1 1.8 1 0 0 1 1 1 1 F5/8 type C domain HEAT_2 PF13646.6 EMC83832.1 - 1.8e-08 34.7 14.7 3.5 8.1 0.1 9.0 7 1 2 9 9 9 3 HEAT repeats HEAT PF02985.22 EMC83832.1 - 4.2e-08 32.8 35.2 0.017 15.3 0.7 11.1 12 0 0 12 12 12 4 HEAT repeat Vac14_Fab1_bd PF12755.7 EMC83832.1 - 0.00037 21.0 0.0 0.012 16.2 0.0 3.6 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EMC83832.1 - 0.077 13.5 30.4 0.079 13.5 0.6 9.0 9 0 0 9 9 9 0 HEAT-like repeat OSCP PF00213.18 EMC83832.1 - 0.083 13.0 0.0 0.27 11.3 0.0 1.9 1 0 0 1 1 1 0 ATP synthase delta (OSCP) subunit Tyr_Deacylase PF02580.16 EMC83833.1 - 1.1e-30 107.1 0.0 1.2e-30 106.9 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase ParA PF10609.9 EMC83834.1 - 1.9e-92 309.2 0.6 2.9e-92 308.6 0.6 1.2 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EMC83834.1 - 1e-07 32.1 0.9 2e-05 24.6 1.0 2.5 2 1 0 2 2 2 2 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EMC83834.1 - 6.7e-07 29.4 0.9 7.4e-05 22.7 0.7 2.2 2 0 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.15 EMC83834.1 - 4.1e-05 22.9 0.6 0.0012 18.2 0.3 2.6 2 1 1 3 3 3 1 Anion-transporting ATPase MipZ PF09140.11 EMC83834.1 - 9e-05 21.9 1.0 0.00025 20.4 0.5 1.9 2 0 0 2 2 2 1 ATPase MipZ Fer4_NifH PF00142.18 EMC83834.1 - 0.00084 18.9 0.2 0.0093 15.4 0.0 2.1 2 1 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_25 PF13481.6 EMC83834.1 - 0.004 16.8 0.5 0.0094 15.5 0.1 1.7 2 0 0 2 2 2 1 AAA domain AAA_26 PF13500.6 EMC83834.1 - 0.072 12.9 0.2 0.88 9.4 0.0 2.4 2 1 0 2 2 2 0 AAA domain RhoGAP PF00620.27 EMC83835.1 - 4.2e-48 163.0 0.8 7.9e-48 162.1 0.0 1.9 2 0 0 2 2 2 1 RhoGAP domain RhoGAP-FF1 PF16512.5 EMC83835.1 - 4.6e-30 104.1 14.0 2e-28 98.9 6.6 4.3 4 0 0 4 4 4 1 p190-A and -B Rho GAPs FF domain Ras PF00071.22 EMC83835.1 - 8.5e-14 51.5 3.9 4.9e-05 23.0 0.3 4.5 4 0 0 4 4 4 4 Ras family FF PF01846.19 EMC83835.1 - 3.6e-12 46.3 16.3 7.5e-10 38.8 1.3 4.7 5 0 0 5 5 5 3 FF domain AAA_22 PF13401.6 EMC83835.1 - 0.0038 17.5 0.1 2.2 8.6 0.1 3.0 2 0 0 2 2 2 1 AAA domain NOG1 PF06858.14 EMC83835.1 - 0.0062 16.3 0.1 0.02 14.7 0.1 1.9 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) GTP_EFTU PF00009.27 EMC83835.1 - 0.0084 15.7 0.2 0.029 13.9 0.2 1.9 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Roc PF08477.13 EMC83835.1 - 0.015 15.5 0.1 0.63 10.3 0.0 2.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EMC83835.1 - 0.07 13.2 0.0 0.48 10.5 0.0 2.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase U5_2-snRNA_bdg PF10597.9 EMC83835.1 - 0.095 12.8 0.8 0.31 11.1 0.2 2.0 2 0 0 2 2 2 0 U5-snRNA binding site 2 of PrP8 Spectrin PF00435.21 EMC83836.1 - 4.3e-09 36.8 32.5 4.4e-05 23.9 3.5 6.4 6 1 0 6 6 6 3 Spectrin repeat 7tm_7 PF08395.12 EMC83836.1 - 0.023 13.9 3.6 0.19 10.9 0.1 2.3 2 0 0 2 2 2 0 7tm Chemosensory receptor HLH PF00010.26 EMC83837.1 - 2.7e-05 24.0 0.6 3.6e-05 23.6 0.6 1.2 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Eapp_C PF10238.9 EMC83838.1 - 3e-52 176.6 9.8 3e-52 176.6 9.8 2.1 3 0 0 3 3 3 1 E2F-associated phosphoprotein C1_4 PF07975.12 EMC83838.1 - 0.038 14.2 3.0 0.071 13.4 0.3 2.5 2 0 0 2 2 2 0 TFIIH C1-like domain IBR PF01485.21 EMC83838.1 - 0.045 14.0 2.2 0.41 10.9 0.2 2.5 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain YMF19 PF02326.15 EMC83838.1 - 0.52 11.1 1.9 0.7 10.7 0.4 2.0 2 0 0 2 2 2 0 Plant ATP synthase F0 DUF2489 PF10675.9 EMC83838.1 - 0.7 9.8 5.8 0.092 12.7 1.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) Yippee-Mis18 PF03226.14 EMC83838.1 - 3.1 8.0 8.4 8.9 6.6 8.4 1.8 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Ribosomal_L34e PF01199.18 EMC83839.1 - 8e-05 22.9 11.7 2.1 8.7 0.1 5.9 2 2 2 5 5 5 3 Ribosomal protein L34e zf-LSD1 PF06943.12 EMC83839.1 - 4.6 7.2 14.6 3.5e+02 1.1 0.2 8.0 7 0 0 7 7 7 0 LSD1 zinc finger Vps5 PF09325.10 EMC83840.1 - 5e-16 59.0 15.4 2.7e-14 53.3 11.7 2.7 2 1 0 2 2 2 1 Vps5 C terminal like PX PF00787.24 EMC83840.1 - 5.6e-16 58.5 0.9 1.1e-13 51.2 0.1 3.2 3 0 0 3 3 3 1 PX domain BAR PF03114.18 EMC83840.1 - 1e-06 28.6 16.1 1.7e-05 24.6 9.3 2.7 3 0 0 3 3 3 2 BAR domain SL4P PF17618.2 EMC83841.1 - 0.083 12.9 0.2 0.14 12.2 0.2 1.4 1 0 0 1 1 1 0 Uncharacterized Strongylid L4 protein Cofilin_ADF PF00241.20 EMC83842.1 - 2.3e-33 114.5 0.9 3.1e-33 114.1 0.9 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Methyltransf_11 PF08241.12 EMC83843.1 - 2.8e-05 24.7 0.1 6.6e-05 23.5 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 EMC83843.1 - 8.4e-05 22.1 0.1 0.00013 21.6 0.1 1.3 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_12 PF08242.12 EMC83843.1 - 0.00012 22.8 0.0 0.00022 21.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC83843.1 - 0.00023 21.8 0.1 0.0005 20.7 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 EMC83843.1 - 0.0061 16.3 0.1 0.01 15.6 0.1 1.3 1 0 0 1 1 1 1 Met-10+ like-protein FmrO PF07091.11 EMC83843.1 - 0.0085 15.7 0.1 0.013 15.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal RNA methyltransferase (FmrO) DOT1 PF08123.13 EMC83843.1 - 0.023 14.3 1.7 0.25 10.8 1.5 2.3 1 1 0 1 1 1 0 Histone methylation protein DOT1 YdfZ PF14001.6 EMC83843.1 - 0.14 12.6 0.0 0.33 11.4 0.0 1.6 1 0 0 1 1 1 0 YdfZ protein SRP54 PF00448.22 EMC83844.1 - 1.8e-77 259.5 0.4 7.2e-77 257.5 0.1 2.1 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EMC83844.1 - 2.4e-30 105.0 2.8 2.4e-30 105.0 2.8 2.6 2 1 1 3 3 2 1 Signal peptide binding domain SRP54_N PF02881.19 EMC83844.1 - 1e-20 73.7 3.1 3.3e-20 72.1 3.1 2.0 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain FAM177 PF14774.6 EMC83844.1 - 3.5e-09 37.0 0.0 7.5e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 FAM177 family cobW PF02492.19 EMC83844.1 - 3.3e-07 30.1 0.7 3.2e-06 26.8 0.5 2.4 2 1 0 2 2 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 EMC83844.1 - 6.4e-06 26.4 0.0 1.2e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 EMC83844.1 - 3e-05 24.1 0.0 0.00011 22.3 0.0 1.9 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain DUF2209 PF09974.9 EMC83844.1 - 0.00016 22.0 0.3 0.00044 20.6 0.3 1.7 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2209) SRPRB PF09439.10 EMC83844.1 - 0.00024 20.6 0.5 0.62 9.5 0.0 2.7 1 1 0 2 2 2 2 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 EMC83844.1 - 0.00061 20.1 0.5 0.0062 16.8 0.1 2.8 3 1 0 3 3 2 1 AAA domain MeaB PF03308.16 EMC83844.1 - 0.0017 17.4 0.0 0.041 12.9 0.0 2.4 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 EMC83844.1 - 0.0045 16.7 0.0 0.014 15.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_31 PF13614.6 EMC83844.1 - 0.006 16.5 0.6 0.023 14.6 0.0 2.2 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EMC83844.1 - 0.006 16.7 2.0 0.016 15.3 0.2 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_17 PF13207.6 EMC83844.1 - 0.0097 16.3 1.1 0.0097 16.3 1.1 3.0 3 1 0 3 3 1 1 AAA domain ResIII PF04851.15 EMC83844.1 - 0.0098 15.9 0.4 0.027 14.5 0.4 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit GTP_EFTU PF00009.27 EMC83844.1 - 0.011 15.3 0.5 0.094 12.2 0.5 2.2 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EMC83844.1 - 0.015 15.7 0.0 0.038 14.4 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain CLTH PF10607.9 EMC83844.1 - 0.016 15.1 0.0 0.038 13.9 0.0 1.6 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain CLP1_P PF16575.5 EMC83844.1 - 0.022 14.5 0.6 0.83 9.4 0.1 2.5 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop MobB PF03205.14 EMC83844.1 - 0.026 14.4 0.4 0.099 12.5 0.0 2.2 2 1 1 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B APS_kinase PF01583.20 EMC83844.1 - 0.031 14.2 0.0 0.065 13.1 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_18 PF13238.6 EMC83844.1 - 0.032 14.8 0.1 0.099 13.2 0.1 2.0 1 1 0 1 1 1 0 AAA domain 6PF2K PF01591.18 EMC83844.1 - 0.04 13.2 0.0 0.099 11.9 0.0 1.6 1 0 0 1 1 1 0 6-phosphofructo-2-kinase ATP_bind_1 PF03029.17 EMC83844.1 - 0.044 13.6 2.4 0.18 11.6 0.1 2.8 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_28 PF13521.6 EMC83844.1 - 0.044 14.0 0.0 0.085 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.20 EMC83844.1 - 0.049 12.8 0.4 0.38 9.9 0.3 2.5 1 1 0 1 1 1 0 G-protein alpha subunit AAA_15 PF13175.6 EMC83844.1 - 0.067 12.9 0.3 0.49 10.0 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain PduV-EutP PF10662.9 EMC83844.1 - 0.079 12.7 0.4 0.86 9.3 0.1 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.29 EMC83844.1 - 0.2 12.1 3.9 0.43 11.0 0.1 3.2 3 2 1 4 4 1 0 ATPase family associated with various cellular activities (AAA) YlbD_coat PF14071.6 EMC83844.1 - 3.1 8.1 8.4 7.8 6.8 2.4 4.0 2 1 1 3 3 3 0 Putative coat protein ArsA_ATPase PF02374.15 EMC83844.1 - 7.4 5.7 8.8 0.32 10.1 0.1 3.2 4 1 1 5 5 5 0 Anion-transporting ATPase EF-hand_7 PF13499.6 EMC83845.1 - 5.7e-09 36.3 7.6 4.8e-05 23.7 0.1 4.9 4 1 1 5 5 5 2 EF-hand domain pair EF-hand_6 PF13405.6 EMC83845.1 - 1.4e-06 27.8 3.9 0.43 10.6 0.1 5.4 5 0 0 5 5 5 2 EF-hand domain EF-hand_13 PF17958.1 EMC83845.1 - 5.9e-06 26.0 0.1 4.1e-05 23.3 0.0 2.5 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 EMC83845.1 - 7.7e-05 22.0 1.9 0.23 11.1 0.0 4.0 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 EMC83845.1 - 0.008 16.0 0.0 1.6 8.6 0.0 3.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 EMC83845.1 - 0.024 14.2 0.9 0.12 11.9 0.0 2.7 3 0 0 3 3 3 0 EF hand PRORP PF16953.5 EMC83846.1 - 5.9e-90 301.0 1.9 1e-89 300.2 1.9 1.4 1 0 0 1 1 1 1 Protein-only RNase P PPR_2 PF13041.6 EMC83846.1 - 1.7e-07 31.3 0.2 0.17 12.1 0.0 3.8 1 1 2 3 3 3 3 PPR repeat family PPR PF01535.20 EMC83846.1 - 2e-05 24.5 8.5 0.065 13.5 0.0 4.8 5 0 0 5 5 5 2 PPR repeat RNase_Zc3h12a PF11977.8 EMC83846.1 - 0.00031 20.6 0.0 0.00084 19.1 0.0 1.8 1 1 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain PPR_long PF17177.4 EMC83846.1 - 0.013 14.9 0.0 0.025 14.0 0.0 1.6 1 0 0 1 1 1 0 Pentacotripeptide-repeat region of PRORP Rad50_zn_hook PF04423.14 EMC83846.1 - 0.068 13.0 0.1 0.68 9.8 0.1 2.4 2 0 0 2 2 2 0 Rad50 zinc hook motif Proteasome PF00227.26 EMC83847.1 - 2.5e-53 180.4 0.2 2.9e-53 180.2 0.2 1.0 1 0 0 1 1 1 1 Proteasome subunit Ank_5 PF13857.6 EMC83848.1 - 3.9e-27 94.0 4.8 3.1e-10 40.1 0.0 3.8 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EMC83848.1 - 4e-27 93.4 8.6 5.9e-07 29.6 0.2 5.1 5 0 0 5 5 5 4 Ankyrin repeat Ank_2 PF12796.7 EMC83848.1 - 6.7e-27 93.9 4.7 3.3e-13 50.0 0.3 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC83848.1 - 1.4e-23 80.4 4.8 7e-06 26.0 0.0 4.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 EMC83848.1 - 8.2e-21 74.1 1.6 8.9e-09 35.7 0.2 4.0 2 2 2 4 4 4 4 Ankyrin repeats (many copies) CRR7 PF12095.8 EMC83848.1 - 0.038 14.5 0.3 0.16 12.4 0.0 2.1 2 0 0 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 Rap_GAP PF02145.15 EMC83849.1 - 1.8e-46 158.0 0.0 4.5e-46 156.7 0.0 1.7 1 0 0 1 1 1 1 Rap/ran-GAP Sds3 PF08598.11 EMC83850.1 - 7.1e-25 88.3 8.7 2.5e-24 86.5 8.9 1.5 1 1 1 2 2 2 1 Sds3-like Borrelia_P83 PF05262.11 EMC83850.1 - 0.21 10.0 5.7 0.29 9.6 5.7 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Receptor_IA-2 PF11548.8 EMC83851.1 - 0.12 12.4 0.0 0.34 10.9 0.0 1.8 1 0 0 1 1 1 0 Protein-tyrosine phosphatase receptor IA-2 Homeodomain PF00046.29 EMC83852.1 - 1.9e-20 72.4 4.8 3.4e-20 71.6 4.8 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC83852.1 - 0.078 12.9 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 Homeobox KN domain PAX PF00292.18 EMC83853.1 - 3e-66 221.0 0.2 4.6e-66 220.4 0.2 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.6 EMC83853.1 - 7.2e-07 28.8 0.2 2e-06 27.4 0.0 1.9 2 0 0 2 2 2 1 Homeodomain-like domain HTH_32 PF13565.6 EMC83853.1 - 1.2e-05 25.8 0.3 0.00028 21.4 0.0 2.4 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 EMC83853.1 - 0.0075 16.3 0.0 0.016 15.2 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 EMC83853.1 - 0.038 14.1 0.0 0.14 12.3 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain Mito_carr PF00153.27 EMC83854.1 - 3.7e-50 167.8 1.9 2.3e-19 69.1 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF4382 PF14321.6 EMC83855.1 - 0.013 15.8 0.7 0.03 14.5 0.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4382) Surfac_D-trimer PF09006.11 EMC83855.1 - 0.11 12.4 1.0 0.78 9.7 0.1 2.8 2 0 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation TPR_1 PF00515.28 EMC83856.1 - 2.4e-63 207.5 48.3 4e-06 26.4 0.2 16.8 14 3 1 15 15 15 13 Tetratricopeptide repeat TPR_2 PF07719.17 EMC83856.1 - 3.2e-55 179.8 36.6 3.2e-05 23.7 0.0 17.1 16 2 1 17 17 16 12 Tetratricopeptide repeat TPR_11 PF13414.6 EMC83856.1 - 3.3e-44 148.3 30.0 1.6e-07 30.9 0.8 14.5 9 4 6 15 15 15 10 TPR repeat TPR_8 PF13181.6 EMC83856.1 - 1.2e-41 137.5 32.5 0.00024 21.1 0.1 15.7 14 2 1 15 15 15 11 Tetratricopeptide repeat TPR_9 PF13371.6 EMC83856.1 - 3.9e-36 123.0 2.4 2.7e-06 27.5 0.0 9.3 5 3 5 10 10 9 7 Tetratricopeptide repeat TPR_17 PF13431.6 EMC83856.1 - 9.5e-32 107.1 24.5 0.00044 20.4 1.1 13.0 14 0 0 14 14 14 7 Tetratricopeptide repeat TPR_16 PF13432.6 EMC83856.1 - 2.6e-25 88.8 5.1 1.2e-05 25.8 0.0 9.9 6 3 6 13 13 12 5 Tetratricopeptide repeat TPR_19 PF14559.6 EMC83856.1 - 5.6e-23 81.2 14.2 8.9e-06 26.1 0.0 9.3 5 2 5 10 10 10 7 Tetratricopeptide repeat TPR_12 PF13424.6 EMC83856.1 - 1.6e-21 76.4 25.1 7.9e-06 26.1 0.0 11.6 5 3 6 11 11 11 6 Tetratricopeptide repeat TPR_14 PF13428.6 EMC83856.1 - 4.2e-20 70.7 3.3 0.41 11.6 0.0 12.8 7 5 8 15 15 14 2 Tetratricopeptide repeat TPR_6 PF13174.6 EMC83856.1 - 2.3e-14 53.0 26.1 1.7 9.4 0.0 12.9 15 0 0 15 15 14 4 Tetratricopeptide repeat TPR_7 PF13176.6 EMC83856.1 - 4e-14 51.5 12.9 0.088 12.9 0.0 9.8 9 1 1 10 10 9 5 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC83856.1 - 2.6e-09 37.2 30.5 0.011 15.9 2.0 7.2 5 2 1 8 8 7 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 EMC83856.1 - 6.4e-07 28.9 1.6 6.5 5.9 0.0 6.5 3 2 2 6 6 6 1 Tetratricopeptide repeat NARP1 PF12569.8 EMC83856.1 - 7.9e-06 25.0 1.7 0.41 9.5 0.1 4.8 3 3 2 5 5 5 1 NMDA receptor-regulated protein 1 SHNi-TPR PF10516.9 EMC83856.1 - 7.6e-05 22.1 9.5 0.2 11.1 0.0 8.3 10 0 0 10 10 10 1 SHNi-TPR Fis1_TPR_C PF14853.6 EMC83856.1 - 0.00071 19.6 12.4 0.24 11.5 0.0 5.4 6 0 0 6 6 5 2 Fis1 C-terminal tetratricopeptide repeat TPR_20 PF14561.6 EMC83856.1 - 0.0012 19.1 0.6 11 6.4 0.0 5.5 4 2 3 7 7 7 0 Tetratricopeptide repeat TPR_10 PF13374.6 EMC83856.1 - 0.0018 18.1 16.3 13 5.8 0.0 8.7 10 0 0 10 10 10 0 Tetratricopeptide repeat MAS20 PF02064.15 EMC83856.1 - 0.024 14.7 2.0 1.1 9.3 0.1 4.3 4 1 1 5 5 5 0 MAS20 protein import receptor Cys_rich_VLP PF14194.6 EMC83856.1 - 2.5 8.3 5.6 33 4.7 0.0 4.1 4 0 0 4 4 4 0 Cysteine-rich VLP 7tm_1 PF00001.21 EMC83857.1 - 1.3e-63 214.8 27.0 1.7e-63 214.4 27.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC83857.1 - 4.9e-14 52.3 23.8 6.1e-14 52.0 23.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC83857.1 - 6e-10 39.2 22.6 1.8e-09 37.6 22.5 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 EMC83857.1 - 7.2e-09 35.4 14.7 7.2e-09 35.4 14.7 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 EMC83857.1 - 0.0003 20.6 22.9 0.00063 19.6 22.9 1.5 1 1 0 1 1 1 1 Olfactory receptor Piezo_RRas_bdg PF12166.8 EMC83857.1 - 0.0041 16.5 0.9 0.14 11.4 0.1 2.3 2 0 0 2 2 2 1 Piezo non-specific cation channel, R-Ras-binding domain T2SSM PF04612.12 EMC83857.1 - 0.079 13.0 0.2 0.079 13.0 0.2 1.8 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M COX7C PF02935.16 EMC83857.1 - 0.38 11.0 8.1 0.54 10.6 0.3 2.8 3 0 0 3 3 3 0 Cytochrome c oxidase subunit VIIc DUF3995 PF13160.6 EMC83857.1 - 8.4 6.8 11.8 9.5 6.6 3.4 2.7 2 2 0 2 2 2 0 Protein of unknown function (DUF3995) Sec23_trunk PF04811.15 EMC83858.1 - 1.5e-79 267.0 0.0 2.1e-79 266.5 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EMC83858.1 - 3.1e-33 114.4 0.0 6.9e-33 113.3 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 EMC83858.1 - 1.1e-27 95.9 0.1 2.7e-27 94.6 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.22 EMC83858.1 - 2.7e-15 56.0 0.0 8.6e-15 54.4 0.0 1.8 2 0 0 2 2 2 1 Gelsolin repeat zf-Sec23_Sec24 PF04810.15 EMC83858.1 - 2.7e-15 56.1 6.7 5.1e-15 55.2 6.7 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger APP_E2 PF12925.7 EMC83858.1 - 0.013 15.2 0.0 0.029 14.1 0.0 1.5 1 0 0 1 1 1 0 E2 domain of amyloid precursor protein SIP1 PF04938.12 EMC83859.1 - 5.2e-79 265.0 0.6 6.1e-79 264.8 0.6 1.0 1 0 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) TRAPP PF04051.16 EMC83860.1 - 9.8e-33 112.9 0.1 1.1e-32 112.8 0.1 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Pinin_SDK_memA PF04696.13 EMC83861.1 - 2.6e-34 118.1 20.7 2.6e-34 118.1 20.7 6.1 5 2 1 6 6 6 1 pinin/SDK/memA/ protein conserved region Pinin_SDK_N PF04697.13 EMC83861.1 - 5.2e-29 101.6 4.1 5.2e-29 101.6 4.1 4.9 4 1 1 5 5 5 1 pinin/SDK conserved region SH3_2 PF07653.17 EMC83862.1 - 9e-11 41.3 0.0 1.3e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC83862.1 - 0.021 14.5 0.1 0.065 12.8 0.0 1.9 2 0 0 2 2 2 0 SH3 domain NPIP PF06409.11 EMC83863.1 - 4.5e-06 25.9 17.5 0.00045 19.4 8.6 2.8 3 0 0 3 3 3 2 Nuclear pore complex interacting protein (NPIP) DUF4200 PF13863.6 EMC83863.1 - 0.0025 18.2 8.8 0.0025 18.2 8.8 4.9 2 2 2 5 5 5 2 Domain of unknown function (DUF4200) DUF1664 PF07889.12 EMC83863.1 - 0.0098 15.9 7.6 0.0098 15.9 7.6 4.6 3 2 2 5 5 5 2 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 EMC83863.1 - 0.021 15.2 3.5 0.021 15.2 3.5 5.6 5 1 1 6 6 6 0 Flagella accessory protein C (FlaC) Filo_VP35 PF02097.15 EMC83863.1 - 1.3 8.0 6.5 2 7.4 0.5 2.6 2 1 0 2 2 2 0 Filoviridae VP35 EzrA PF06160.12 EMC83863.1 - 1.5 6.9 62.7 0.69 8.0 28.0 2.7 2 2 0 2 2 2 0 Septation ring formation regulator, EzrA zf-H2C2_2 PF13465.6 EMC83865.1 - 7.7e-24 83.0 30.6 1.8e-06 28.1 0.3 6.3 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2 PF00096.26 EMC83865.1 - 3.4e-23 80.7 26.7 2.8e-05 24.3 0.1 5.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC83865.1 - 2.5e-14 52.8 28.1 0.0012 19.5 4.0 5.6 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EMC83865.1 - 3.5e-05 23.5 13.4 0.4 10.5 0.1 3.7 3 0 0 3 3 3 3 zinc-finger C2H2-type zf-C2HC_2 PF13913.6 EMC83865.1 - 7.6e-05 22.5 8.5 0.21 11.5 0.0 4.8 5 0 0 5 5 5 2 zinc-finger of a C2HC-type zf-C2H2_8 PF15909.5 EMC83865.1 - 8.9e-05 22.7 7.8 0.012 15.9 1.5 3.5 2 1 3 5 5 5 3 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.5 EMC83865.1 - 0.00013 22.2 7.9 2.1 8.5 0.1 4.4 1 1 3 4 4 4 2 Aberrant zinc-finger zf-met PF12874.7 EMC83865.1 - 0.0018 18.6 7.5 0.94 10.0 0.1 4.3 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMC83865.1 - 0.014 15.6 8.5 2.4 8.5 0.0 4.5 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding CHORD PF04968.12 EMC83865.1 - 0.18 12.6 13.1 4.4 8.1 0.1 4.9 2 1 3 5 5 5 0 CHORD zf-DNA_Pol PF08996.10 EMC83865.1 - 0.5 10.1 3.6 7 6.3 0.1 2.5 1 1 1 2 2 2 0 DNA Polymerase alpha zinc finger zf-C2H2_6 PF13912.6 EMC83865.1 - 0.6 10.2 31.1 6.2 6.9 0.2 6.1 5 1 0 5 5 5 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EMC83865.1 - 0.68 10.3 10.6 0.24 11.8 1.1 3.6 1 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) UPF0564 PF10595.9 EMC83866.1 - 4.4e-73 246.4 39.5 6.5e-73 245.9 39.5 1.3 1 0 0 1 1 1 1 Uncharacterised protein family UPF0564 FAD_binding_3 PF01494.19 EMC83867.1 - 1.2e-18 67.5 0.5 2.7e-10 40.0 0.1 2.8 3 0 0 3 3 3 2 FAD binding domain Trp_halogenase PF04820.14 EMC83867.1 - 0.00022 20.2 0.4 0.58 9.0 0.0 3.1 3 0 0 3 3 3 2 Tryptophan halogenase SE PF08491.10 EMC83867.1 - 0.00029 20.0 0.0 0.00065 18.8 0.0 1.5 2 0 0 2 2 2 1 Squalene epoxidase GDA1_CD39 PF01150.17 EMC83868.1 - 2e-79 267.2 0.0 8.4e-79 265.2 0.0 1.8 1 1 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Aldedh PF00171.22 EMC83869.1 - 6.4e-137 456.8 0.0 7.2e-137 456.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EMC83869.1 - 0.01 15.0 0.0 0.023 13.8 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) AMP-binding PF00501.28 EMC83870.1 - 2.2e-10 39.7 0.0 2.8e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMC83870.1 - 4.1e-10 40.5 1.8 7.3e-10 39.7 1.8 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF2895 PF11444.8 EMC83870.1 - 0.18 11.1 0.0 0.3 10.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2895) ABC_membrane_2 PF06472.15 EMC83871.1 - 8.2e-80 268.1 3.1 1.2e-79 267.6 3.1 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EMC83871.1 - 1.2e-17 64.7 0.0 2.1e-17 63.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_30 PF13604.6 EMC83871.1 - 0.00051 19.8 0.0 0.0054 16.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 EMC83871.1 - 0.0014 18.6 0.0 0.0022 17.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EMC83871.1 - 0.0016 18.8 0.0 0.0035 17.7 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain SbmA_BacA PF05992.12 EMC83871.1 - 0.0032 17.0 2.0 0.0051 16.3 2.0 1.3 1 0 0 1 1 1 1 SbmA/BacA-like family AAA_7 PF12775.7 EMC83871.1 - 0.0092 15.5 0.1 0.017 14.7 0.1 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_23 PF13476.6 EMC83871.1 - 0.014 15.9 0.1 0.026 15.0 0.1 1.3 1 0 0 1 1 1 0 AAA domain IRK PF01007.20 EMC83871.1 - 0.016 15.0 1.0 0.028 14.2 1.0 1.4 1 0 0 1 1 1 0 Inward rectifier potassium channel transmembrane domain AAA_22 PF13401.6 EMC83871.1 - 0.021 15.1 0.1 0.087 13.1 0.1 2.1 2 0 0 2 2 1 0 AAA domain RsgA_GTPase PF03193.16 EMC83871.1 - 0.038 13.9 0.2 0.069 13.0 0.2 1.3 1 0 0 1 1 1 0 RsgA GTPase MMR_HSR1 PF01926.23 EMC83871.1 - 0.047 13.8 0.2 0.22 11.6 0.2 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase NACHT PF05729.12 EMC83871.1 - 0.064 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 EMC83871.1 - 0.066 13.0 0.2 0.14 12.0 0.2 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain DEAD PF00270.29 EMC83871.1 - 0.09 12.5 0.2 0.82 9.4 0.2 2.2 1 1 0 1 1 1 0 DEAD/DEAH box helicase Sigma54_activat PF00158.26 EMC83871.1 - 0.096 12.4 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Roc PF08477.13 EMC83871.1 - 0.13 12.4 0.4 0.5 10.6 0.1 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EMC83871.1 - 0.14 11.9 0.1 0.26 11.1 0.1 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation IstB_IS21 PF01695.17 EMC83871.1 - 0.14 11.9 0.0 0.36 10.5 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF815 PF05673.13 EMC83871.1 - 0.15 11.2 0.0 0.25 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DLIC PF05783.11 EMC83871.1 - 0.19 10.5 0.1 0.3 9.9 0.1 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) CD225 PF04505.12 EMC83872.1 - 9.3e-18 64.1 0.2 1.5e-17 63.5 0.2 1.3 1 0 0 1 1 1 1 Interferon-induced transmembrane protein Fe-S_biosyn PF01521.20 EMC83873.1 - 7.2e-09 35.8 0.0 1.5e-08 34.8 0.0 1.5 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis DUF3117 PF11314.8 EMC83873.1 - 0.28 11.0 1.7 2 8.3 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3117) E1_DerP2_DerF2 PF02221.15 EMC83874.1 - 5.5e-30 104.5 0.4 6.4e-30 104.3 0.4 1.0 1 0 0 1 1 1 1 ML domain TLV_coat PF00429.19 EMC83875.1 - 4.7e-15 55.3 2.9 5.4e-15 55.1 2.1 1.4 1 1 1 2 2 2 1 ENV polyprotein (coat polyprotein) HECT PF00632.25 EMC83876.1 - 1.1e-78 264.8 0.1 1.8e-78 264.1 0.1 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Filamin PF00630.19 EMC83876.1 - 1.6e-10 41.7 1.3 1.1e-06 29.3 0.0 3.4 3 1 0 3 3 3 2 Filamin/ABP280 repeat Fcf1 PF04900.12 EMC83877.1 - 1.1e-39 134.8 2.3 1.8e-39 134.1 2.3 1.4 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 EMC83877.1 - 3.4e-11 43.5 0.0 5.6e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 PIN like domain Imm-NTF2 PF15655.6 EMC83877.1 - 0.062 13.6 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 NTF2 fold immunity protein HPD PF05044.12 EMC83878.1 - 9.2e-81 269.2 0.1 1.1e-80 269.0 0.1 1.0 1 0 0 1 1 1 1 Homeo-prospero domain 2-oxoacid_dh PF00198.23 EMC83879.1 - 9.1e-63 211.8 0.2 1.1e-62 211.5 0.2 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EMC83879.1 - 2.2e-22 78.7 0.4 3.7e-22 77.9 0.4 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EMC83879.1 - 0.0042 16.9 0.0 0.0098 15.7 0.0 1.7 1 0 0 1 1 1 1 Biotin-lipoyl like bPH_6 PF10756.9 EMC83879.1 - 0.073 13.2 0.4 0.18 11.9 0.4 1.7 1 0 0 1 1 1 0 Bacterial PH domain GCV_H PF01597.19 EMC83879.1 - 0.19 11.6 0.7 0.46 10.4 0.6 1.6 1 1 1 2 2 2 0 Glycine cleavage H-protein PDGF PF00341.17 EMC83880.1 - 2.2e-26 92.0 5.7 2.5e-26 91.8 5.7 1.0 1 0 0 1 1 1 1 PDGF/VEGF domain IF-2B PF01008.17 EMC83881.1 - 6.8e-81 271.6 0.1 7.8e-81 271.4 0.1 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family MutL_C PF08676.11 EMC83882.1 - 3.3e-12 46.4 0.3 1.6e-11 44.1 0.3 2.1 1 1 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 EMC83882.1 - 3.4e-11 42.9 0.0 3e-05 23.7 0.0 2.8 3 0 0 3 3 3 2 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EMC83882.1 - 3e-08 33.6 0.1 7.3e-08 32.3 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EMC83882.1 - 4.4e-07 30.4 0.0 1.2e-06 29.0 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Acylphosphatase PF00708.18 EMC83883.1 - 7.8e-14 51.8 0.0 9.3e-14 51.6 0.0 1.0 1 0 0 1 1 1 1 Acylphosphatase zf-C2HC_2 PF13913.6 EMC83884.1 - 1.5e-16 59.8 13.4 1e-08 34.9 4.5 2.4 2 0 0 2 2 2 2 zinc-finger of a C2HC-type zf-CHCC PF10276.9 EMC83884.1 - 0.00014 21.8 2.4 0.035 14.2 0.3 2.3 2 0 0 2 2 2 2 Zinc-finger domain zf-H2C2_2 PF13465.6 EMC83884.1 - 0.0067 16.8 1.7 2.9 8.5 0.2 2.8 2 0 0 2 2 2 2 Zinc-finger double domain zf-CpG_bind_C PF12269.8 EMC83884.1 - 0.0068 16.2 0.8 3.7 7.3 0.7 2.1 1 1 1 2 2 2 2 CpG binding protein zinc finger C terminal domain Nairovirus_M PF07948.11 EMC83884.1 - 0.078 11.2 0.0 0.096 10.9 0.0 1.2 1 0 0 1 1 1 0 Nairovirus M polyprotein-like zinc_ribbon_9 PF14369.6 EMC83884.1 - 0.082 13.2 1.9 0.59 10.4 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon zf-C2HC5 PF06221.13 EMC83884.1 - 0.11 12.5 2.0 2.2 8.3 1.0 2.4 2 0 0 2 2 2 0 Putative zinc finger motif, C2HC5-type zf-C2H2_4 PF13894.6 EMC83884.1 - 0.15 12.9 10.7 3.1 8.9 0.4 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC83884.1 - 0.45 11.1 7.2 8.7 7.0 0.0 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-Di19 PF05605.12 EMC83884.1 - 0.69 10.3 4.9 2.4 8.5 0.4 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C4_ClpX PF06689.13 EMC83884.1 - 2.8 7.9 5.7 2.6 8.0 1.4 2.5 2 0 0 2 2 2 0 ClpX C4-type zinc finger Pkinase PF00069.25 EMC83885.1 - 2.1e-48 165.0 0.1 2.8e-48 164.6 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain RCC1 PF00415.18 EMC83885.1 - 5.4e-48 161.4 24.3 2.1e-13 50.6 0.1 8.1 7 1 1 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EMC83885.1 - 1.1e-34 117.5 23.2 1.9e-08 33.9 0.3 7.2 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Pkinase_Tyr PF07714.17 EMC83885.1 - 1.8e-31 109.3 0.1 2.8e-31 108.7 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC83885.1 - 1.7e-05 23.8 0.0 2.7e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EMC83885.1 - 0.0012 18.2 0.0 0.0021 17.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC83885.1 - 0.17 11.2 0.1 0.3 10.4 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EMP24_GP25L PF01105.24 EMC83886.1 - 8.5e-37 126.9 0.1 9.4e-37 126.7 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD bZIP_1 PF00170.21 EMC83887.1 - 4.2e-11 42.8 9.0 5.8e-11 42.3 9.0 1.1 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMC83887.1 - 8.8e-10 38.5 12.4 1.1e-09 38.3 12.4 1.1 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EMC83887.1 - 4.1e-07 30.4 9.5 5.6e-07 30.0 9.5 1.1 1 0 0 1 1 1 1 bZIP Maf transcription factor Phlebovirus_NSM PF07246.11 EMC83887.1 - 0.00056 19.4 0.2 0.00065 19.2 0.2 1.2 1 0 0 1 1 1 1 Phlebovirus nonstructural protein NS-M TMCO5 PF14992.6 EMC83887.1 - 0.014 15.0 2.7 0.017 14.7 2.7 1.1 1 0 0 1 1 1 0 TMCO5 family APG6_N PF17675.1 EMC83887.1 - 0.025 15.1 4.4 0.03 14.8 4.4 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region HALZ PF02183.18 EMC83887.1 - 0.036 14.3 2.6 0.036 14.3 2.6 1.8 2 0 0 2 2 2 0 Homeobox associated leucine zipper SR-25 PF10500.9 EMC83887.1 - 0.11 12.1 8.8 0.13 11.9 8.8 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AAA_11 PF13086.6 EMC83887.1 - 0.16 11.7 3.9 0.19 11.5 3.9 1.1 1 0 0 1 1 1 0 AAA domain DivIC PF04977.15 EMC83887.1 - 3 7.7 7.3 9.8 6.0 7.3 1.8 1 1 0 1 1 1 0 Septum formation initiator Erg28 PF03694.13 EMC83888.1 - 2.2e-09 37.7 5.8 2.5e-09 37.5 5.8 1.1 1 0 0 1 1 1 1 Erg28 like protein MFS_1_like PF12832.7 EMC83888.1 - 0.0071 15.2 2.9 0.0074 15.2 2.9 1.0 1 0 0 1 1 1 1 MFS_1 like family DUF1427 PF07235.11 EMC83888.1 - 0.067 13.1 0.0 0.075 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1427) DUF1129 PF06570.11 EMC83888.1 - 0.069 12.6 2.8 0.074 12.5 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) TTL PF03133.15 EMC83889.1 - 1.8e-90 303.0 0.0 4.5e-90 301.8 0.0 1.6 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EMC83889.1 - 1.1e-07 31.4 0.0 0.00095 18.5 0.0 2.9 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 EMC83889.1 - 0.0014 18.0 0.0 0.18 11.0 0.0 2.3 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp XkdW PF09636.10 EMC83889.1 - 0.0062 16.6 0.5 0.84 9.7 0.3 2.9 2 0 0 2 2 2 1 XkdW protein GIDA PF01134.22 EMC83889.1 - 0.076 12.1 0.4 0.13 11.3 0.4 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A TGF_beta PF00019.20 EMC83890.1 - 2.4e-24 86.3 1.0 4.1e-24 85.6 1.0 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 EMC83890.1 - 2e-20 73.6 0.0 2.6e-20 73.2 0.0 1.2 1 0 0 1 1 1 1 TGF-beta propeptide IFT43 PF15305.6 EMC83891.1 - 2.6e-43 147.5 3.9 3e-43 147.2 3.9 1.0 1 0 0 1 1 1 1 Intraflagellar transport protein 43 Hormone_recep PF00104.30 EMC83893.1 - 6.5e-31 107.5 0.6 1e-30 106.9 0.6 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 EMC83893.1 - 6.7e-31 106.6 12.3 1.3e-30 105.7 12.3 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Vasohibin PF14822.6 EMC83894.1 - 3e-103 344.3 0.0 3.5e-103 344.1 0.0 1.0 1 0 0 1 1 1 1 Vasohibin LRR_6 PF13516.6 EMC83895.1 - 1.2e-33 112.2 27.8 8.6e-05 22.3 0.6 9.5 9 0 0 9 9 9 9 Leucine Rich repeat LRR_1 PF00560.33 EMC83895.1 - 1.6e-11 43.1 8.5 3.4 8.6 0.0 8.9 9 0 0 9 9 9 3 Leucine Rich Repeat EF-hand_6 PF13405.6 EMC83895.1 - 2.1e-06 27.2 0.1 0.0052 16.6 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EMC83895.1 - 1.7e-05 24.0 0.1 0.036 13.6 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EMC83895.1 - 0.0011 19.4 0.2 0.0029 18.0 0.2 1.8 1 0 0 1 1 1 1 EF-hand domain pair LRR_4 PF12799.7 EMC83895.1 - 0.0017 18.7 28.3 0.094 13.2 3.4 5.6 1 1 7 8 8 8 6 Leucine Rich repeats (2 copies) LRR_2 PF07723.13 EMC83895.1 - 0.014 16.0 0.0 56 4.6 0.0 4.4 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_8 PF13855.6 EMC83895.1 - 0.024 14.4 30.8 0.19 11.5 5.1 6.5 5 2 2 7 7 7 0 Leucine rich repeat CiPC PF15800.5 EMC83896.1 - 2.2e-106 356.5 11.2 2.6e-106 356.2 11.2 1.1 1 0 0 1 1 1 1 Clock interacting protein circadian DHHC PF01529.20 EMC83897.1 - 7.5e-21 74.6 9.4 7.5e-21 74.6 9.4 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase InaF-motif PF15018.6 EMC83897.1 - 0.12 12.3 3.6 0.26 11.2 3.6 1.6 1 0 0 1 1 1 0 TRP-interacting helix RSN1_7TM PF02714.15 EMC83898.1 - 1.6e-58 198.2 28.3 1.6e-58 198.2 28.3 2.0 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EMC83898.1 - 4e-50 170.5 0.4 5.7e-50 170.0 0.4 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 EMC83898.1 - 8.2e-24 84.1 2.3 8.2e-24 84.1 2.3 5.2 6 2 0 6 6 6 2 Late exocytosis, associated with Golgi transport Globin PF00042.22 EMC83899.1 - 5.1e-10 39.9 0.0 1.4e-09 38.5 0.0 1.6 2 0 0 2 2 2 1 Globin PMT PF02366.18 EMC83900.1 - 5.5e-79 265.2 13.6 1.1e-78 264.2 13.6 1.5 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EMC83900.1 - 1.3e-52 178.3 8.3 1.3e-52 178.3 8.3 1.8 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EMC83900.1 - 4.5e-22 78.8 0.3 6.7e-22 78.2 0.3 1.2 1 0 0 1 1 1 1 MIR domain GST_N_3 PF13417.6 EMC83901.1 - 3e-18 66.0 0.0 5e-18 65.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EMC83901.1 - 3.4e-16 59.4 0.0 6.4e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EMC83901.1 - 2.1e-15 56.8 0.0 4.2e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EMC83901.1 - 7.8e-08 32.4 0.0 1.3e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EMC83901.1 - 0.00017 21.7 0.0 0.00026 21.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EMC83901.1 - 0.00048 20.1 0.0 0.00076 19.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 EMC83901.1 - 0.02 15.1 0.0 0.053 13.8 0.0 1.7 1 0 0 1 1 1 0 Glutaredoxin GST_C_5 PF16865.5 EMC83901.1 - 0.067 13.8 0.0 0.098 13.2 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GOLD_2 PF13897.6 EMC83902.1 - 7.7e-33 113.9 1.9 1.1e-32 113.4 1.9 1.2 1 0 0 1 1 1 1 Golgi-dynamics membrane-trafficking RGI_lyase PF18370.1 EMC83902.1 - 0.11 12.9 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 Rhamnogalacturonan I lyases beta-sheet domain SAM_1 PF00536.30 EMC83903.1 - 0.16 12.4 0.0 1.6 9.2 0.0 2.1 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Vps16_C PF04840.12 EMC83905.1 - 5.2e-10 38.9 1.9 0.00032 19.8 0.2 2.2 2 0 0 2 2 2 2 Vps16, C-terminal region DUF3105 PF11303.8 EMC83905.1 - 0.088 13.0 0.0 3.7 7.7 0.0 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF3105) AMOP PF03782.17 EMC83906.1 - 2.4e-26 92.6 1.3 2.4e-26 92.6 1.3 1.9 2 0 0 2 2 2 1 AMOP domain TSP_1 PF00090.19 EMC83906.1 - 2.5e-07 30.8 11.8 2.5e-07 30.8 11.8 2.5 3 0 0 3 3 3 1 Thrombospondin type 1 domain PPP4R2 PF09184.11 EMC83906.1 - 0.29 10.7 8.3 0.43 10.1 8.3 1.2 1 0 0 1 1 1 0 PPP4R2 CDC45 PF02724.14 EMC83906.1 - 1.3 7.2 7.7 1.7 6.9 7.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2457 PF10446.9 EMC83906.1 - 1.5 7.9 15.9 2.9 6.9 15.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CobT PF06213.12 EMC83906.1 - 2.1 7.7 9.7 3.2 7.1 9.7 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DNA_pol_phi PF04931.13 EMC83906.1 - 7.5 4.5 16.5 11 3.9 16.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi SDA1 PF05285.12 EMC83906.1 - 7.7 5.8 12.7 11 5.4 12.7 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EMC83906.1 - 8.1 4.5 13.3 10 4.2 13.3 1.1 1 0 0 1 1 1 0 Nop14-like family Aminotran_1_2 PF00155.21 EMC83907.1 - 8.8e-61 206.1 0.0 1.1e-60 205.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EMC83907.1 - 0.0038 16.2 0.0 0.0061 15.5 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V 2OG-FeII_Oxy_2 PF13532.6 EMC83908.1 - 8.3e-39 133.8 0.0 2.5e-38 132.3 0.0 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SKIP_SNW PF02731.15 EMC83909.1 - 2.5e-74 248.3 7.6 2.5e-74 248.3 7.6 2.1 2 0 0 2 2 2 1 SKIP/SNW domain SIR4_SID PF16991.5 EMC83909.1 - 0.3 11.1 2.9 0.74 9.8 2.9 1.6 1 0 0 1 1 1 0 Sir4 SID domain ABC1 PF03109.16 EMC83910.1 - 1.1e-39 135.2 0.1 2e-39 134.4 0.1 1.4 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 EMC83910.1 - 1.2e-06 28.1 0.1 0.00013 21.4 0.1 2.2 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 EMC83910.1 - 0.00065 19.7 0.2 0.17 11.8 0.2 2.8 3 0 0 3 3 3 2 Phosphotransferase enzyme family Laminin_G_2 PF02210.24 EMC83911.1 - 1.2e-19 71.2 0.0 1.7e-19 70.6 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 EMC83911.1 - 1.9e-17 63.7 0.0 2.8e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain EGF PF00008.27 EMC83911.1 - 8.6e-08 32.3 6.7 1.9e-07 31.3 6.7 1.6 1 0 0 1 1 1 1 EGF-like domain EGF_2 PF07974.13 EMC83911.1 - 0.036 14.4 8.1 0.036 14.4 8.1 1.8 2 0 0 2 2 2 0 EGF-like domain hEGF PF12661.7 EMC83911.1 - 0.054 14.1 4.0 0.054 14.1 4.0 2.4 2 0 0 2 2 2 0 Human growth factor-like EGF Laminin_G_3 PF13385.6 EMC83911.1 - 0.06 13.5 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily EGF_alliinase PF04863.13 EMC83911.1 - 2.7 8.5 8.2 5.8 7.4 8.2 1.6 1 0 0 1 1 1 0 Alliinase EGF-like domain Cys_rich_VLP PF14194.6 EMC83911.1 - 5.9 7.1 6.7 1 9.5 2.5 1.9 2 0 0 2 2 2 0 Cysteine-rich VLP Laminin_G_2 PF02210.24 EMC83912.1 - 2e-109 361.3 5.0 1.3e-28 100.1 0.0 4.2 4 0 0 4 4 4 4 Laminin G domain Laminin_G_1 PF00054.23 EMC83912.1 - 2.3e-84 280.1 1.4 2e-25 89.5 0.0 4.4 4 1 0 4 4 4 4 Laminin G domain Laminin_G_3 PF13385.6 EMC83912.1 - 9e-21 74.6 2.8 6.5e-05 23.1 0.2 4.2 4 0 0 4 4 4 4 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.27 EMC83912.1 - 7.1e-08 32.6 20.0 5e-05 23.5 6.2 2.6 2 0 0 2 2 2 2 EGF-like domain DUF1080 PF06439.11 EMC83912.1 - 2.8e-07 30.8 0.3 1.2 9.2 0.0 4.4 4 0 0 4 4 4 3 Domain of Unknown Function (DUF1080) hEGF PF12661.7 EMC83912.1 - 0.00043 20.8 13.5 0.14 12.9 2.7 3.0 2 0 0 2 2 2 2 Human growth factor-like EGF Laminin_G_2 PF02210.24 EMC83913.1 - 2.5e-16 60.4 0.1 3.6e-16 59.9 0.1 1.2 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 EMC83913.1 - 1.3e-05 25.4 0.2 2.1e-05 24.7 0.2 1.7 1 1 0 1 1 1 1 Laminin G domain Na_trans_cytopl PF11933.8 EMC83913.1 - 0.089 12.6 0.1 0.13 12.1 0.1 1.1 1 0 0 1 1 1 0 Cytoplasmic domain of voltage-gated Na+ ion channel DUF3439 PF11921.8 EMC83913.1 - 0.29 11.1 5.3 0.47 10.4 5.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Syndecan PF01034.20 EMC83914.1 - 3.9e-08 33.1 0.8 1.1e-07 31.7 0.8 1.8 1 1 0 1 1 1 1 Syndecan domain CD34_antigen PF06365.12 EMC83914.1 - 0.0071 16.0 0.1 0.0097 15.5 0.1 1.1 1 0 0 1 1 1 1 CD34/Podocalyxin family DUF202 PF02656.15 EMC83914.1 - 0.015 15.7 0.0 0.023 15.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF202) COX14 PF14880.6 EMC83914.1 - 0.14 12.1 0.2 0.29 11.0 0.2 1.5 1 0 0 1 1 1 0 Cytochrome oxidase c assembly Orf78 PF06024.12 EMC83914.1 - 5.3 7.4 5.6 0.67 10.3 0.4 2.0 1 1 1 2 2 2 0 Orf78 (ac78) 7tm_1 PF00001.21 EMC83915.1 - 8.9e-33 113.7 21.8 1.3e-32 113.2 21.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.6 EMC83915.1 - 7.8e-14 51.2 5.7 1.7e-05 24.5 0.3 4.0 2 2 1 3 3 3 3 Leucine rich repeat LRR_5 PF13306.6 EMC83915.1 - 9.1e-12 45.1 2.0 1.1e-06 28.6 0.1 2.6 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) TFIIA PF03153.13 EMC83916.1 - 1.1e-91 309.0 81.9 9.7e-54 183.9 22.9 2.4 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit SelP_N PF04592.14 EMC83916.1 - 0.49 9.7 14.5 0.014 14.8 7.5 1.8 2 0 0 2 2 2 0 Selenoprotein P, N terminal region DUF4746 PF15928.5 EMC83916.1 - 1.8 7.9 14.6 0.76 9.1 3.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Pox_Ag35 PF03286.14 EMC83916.1 - 8.6 6.1 13.3 1 9.1 7.8 2.0 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Stonin2_N PF12016.8 EMC83917.1 - 1e-161 538.1 41.1 1.7e-161 537.4 41.1 1.4 1 0 0 1 1 1 1 Stonin 2 Adap_comp_sub PF00928.21 EMC83917.1 - 2.6e-59 200.8 0.1 5e-59 199.8 0.1 1.5 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Sel1 PF08238.12 EMC83918.1 - 3.5e-65 215.0 35.3 1.1e-09 38.6 0.5 12.7 13 0 0 13 13 13 11 Sel1 repeat fn2 PF00040.19 EMC83918.1 - 1.3e-17 63.7 5.9 2.4e-17 62.9 5.9 1.5 1 0 0 1 1 1 1 Fibronectin type II domain SF3A2 PF16835.5 EMC83918.1 - 0.054 13.9 0.2 2.2 8.7 0.0 2.5 2 0 0 2 2 2 0 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) S6PP_C PF08472.10 EMC83918.1 - 0.15 11.9 0.0 2 8.3 0.0 2.4 2 0 0 2 2 2 0 Sucrose-6-phosphate phosphohydrolase C-terminal TPR_16 PF13432.6 EMC83918.1 - 5.6 7.7 10.0 9.3 7.0 0.9 4.7 3 2 0 3 3 3 0 Tetratricopeptide repeat MACPF PF01823.19 EMC83921.1 - 1.9e-21 77.2 0.0 3.1e-21 76.4 0.0 1.2 1 0 0 1 1 1 1 MAC/Perforin domain DUF4468 PF14730.6 EMC83921.1 - 0.16 12.3 0.0 0.39 11.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4468) with TBP-like fold cEGF PF12662.7 EMC83921.1 - 2.6 8.1 4.5 20 5.2 0.1 3.4 3 0 0 3 3 3 0 Complement Clr-like EGF-like DTC PF18102.1 EMC83922.1 - 2.9e-58 195.7 0.0 4.5e-58 195.1 0.0 1.3 1 0 0 1 1 1 1 Deltex C-terminal domain zf-RING_UBOX PF13445.6 EMC83922.1 - 4.3e-08 33.1 1.2 1e-07 31.9 1.2 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EMC83922.1 - 1.1e-07 32.0 2.1 4.3e-07 30.2 2.1 2.0 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EMC83922.1 - 1.6e-07 31.0 1.6 3.2e-07 30.1 1.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMC83922.1 - 3.3e-06 27.3 1.0 3.3e-06 27.3 1.0 1.9 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EMC83922.1 - 1.1e-05 25.3 1.5 2.6e-05 24.1 1.5 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EMC83922.1 - 8.8e-05 22.5 1.5 0.0002 21.3 1.4 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 EMC83922.1 - 0.00015 21.5 4.6 0.012 15.4 0.8 2.7 2 0 0 2 2 2 2 RING-like zinc finger zf-C3HC4_2 PF13923.6 EMC83922.1 - 0.0011 18.7 6.3 0.42 10.5 3.5 2.7 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMC83922.1 - 0.0035 17.5 3.1 0.014 15.5 1.0 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-UDP PF14569.6 EMC83922.1 - 0.012 15.7 1.0 0.019 15.0 0.1 1.8 2 0 0 2 2 1 0 Zinc-binding RING-finger Zn_ribbon_17 PF17120.5 EMC83922.1 - 0.013 15.1 1.8 0.014 15.0 0.3 1.8 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 EMC83922.1 - 0.033 14.0 2.4 0.13 12.1 2.5 2.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 FANCL_C PF11793.8 EMC83922.1 - 0.042 14.0 2.1 0.15 12.3 2.1 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain Trm112p PF03966.16 EMC83922.1 - 0.046 14.3 0.1 0.089 13.4 0.1 1.5 1 0 0 1 1 1 0 Trm112p-like protein PHD PF00628.29 EMC83922.1 - 0.079 12.9 0.7 0.079 12.9 0.7 2.2 2 0 0 2 2 2 0 PHD-finger zf-RING_4 PF14570.6 EMC83922.1 - 0.1 12.4 1.7 0.17 11.7 0.2 2.0 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 EMC83922.1 - 0.18 11.7 1.9 3.9 7.4 0.4 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) ADK_lid PF05191.14 EMC83922.1 - 0.38 10.8 4.2 2.9 8.0 0.2 3.3 3 0 0 3 3 3 0 Adenylate kinase, active site lid zf-RING-like PF08746.11 EMC83922.1 - 1.2 9.5 4.4 0.56 10.6 1.2 2.1 2 0 0 2 2 2 0 RING-like domain IRK_C PF17655.1 EMC83924.1 - 9.4e-75 250.0 0.1 1.3e-74 249.6 0.1 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 EMC83924.1 - 9.5e-58 194.0 2.6 1.3e-57 193.5 2.6 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 EMC83924.1 - 0.025 14.6 9.0 0.073 13.0 9.0 1.8 1 1 0 1 1 1 0 Ion channel Ion_trans PF00520.31 EMC83924.1 - 0.045 13.0 3.2 0.068 12.4 3.2 1.2 1 0 0 1 1 1 0 Ion transport protein IRK_C PF17655.1 EMC83925.1 - 1.1e-70 236.8 0.0 1.5e-70 236.3 0.0 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 EMC83925.1 - 4.3e-58 195.1 1.5 4.3e-58 195.1 1.5 1.7 2 0 0 2 2 2 1 Inward rectifier potassium channel transmembrane domain DUF2182 PF09948.9 EMC83925.1 - 0.023 14.6 1.0 0.052 13.4 0.1 1.9 2 1 1 3 3 3 0 Predicted metal-binding integral membrane protein (DUF2182) CrgA PF06781.12 EMC83925.1 - 0.1 12.7 0.1 0.26 11.4 0.1 1.7 1 0 0 1 1 1 0 Cell division protein CrgA Ets PF00178.22 EMC83926.1 - 2.9e-36 123.8 0.4 6.5e-36 122.7 0.4 1.6 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.16 EMC83926.1 - 1.3e-26 92.4 0.1 2.5e-26 91.4 0.1 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Ig_3 PF13927.6 EMC83927.1 - 1.7e-45 153.5 0.7 4.2e-11 43.3 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 EMC83927.1 - 2.1e-42 143.1 0.1 9e-12 44.9 0.0 5.7 5 2 0 5 5 5 5 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC83927.1 - 1.7e-36 124.4 0.1 3.4e-07 30.5 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 EMC83927.1 - 1.7e-24 85.8 2.3 5.7e-05 23.2 1.1 5.8 5 1 0 5 5 5 4 Immunoglobulin domain C2-set_2 PF08205.12 EMC83927.1 - 1.8e-13 50.4 0.1 9.4e-08 32.0 0.0 4.4 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 EMC83927.1 - 2.2e-12 47.1 1.0 0.49 10.6 0.0 7.4 5 3 1 6 6 6 3 Immunoglobulin V-set domain C1-set PF07654.15 EMC83927.1 - 6.2e-07 29.7 0.0 0.00068 20.0 0.0 4.4 4 1 0 4 4 4 1 Immunoglobulin C1-set domain Ig_5 PF16681.5 EMC83927.1 - 3.8e-05 24.0 0.1 1.2 9.6 0.0 5.4 6 0 0 6 6 6 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 EMC83927.1 - 5.5e-05 23.4 0.0 0.014 15.6 0.0 4.2 5 0 0 5 5 5 1 T-cell surface glycoprotein CD3 delta chain Mid2 PF04478.12 EMC83927.1 - 0.02 14.7 0.1 0.046 13.5 0.1 1.5 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor EIIBC-GUT_N PF03612.14 EMC83927.1 - 0.045 13.5 0.0 0.093 12.5 0.0 1.5 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Izumo-Ig PF16706.5 EMC83927.1 - 0.059 13.4 0.0 0.23 11.5 0.0 2.0 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 EMC83927.1 - 0.13 11.9 0.0 0.36 10.4 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin domain Glyco_transf_29 PF00777.18 EMC83928.1 - 1.5e-66 224.6 0.0 1.8e-66 224.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) DcpS_C PF11969.8 EMC83929.1 - 2.2e-32 111.9 0.2 7.9e-32 110.1 0.0 1.8 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.12 EMC83929.1 - 2.4e-13 50.8 0.0 4.2e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal HIT PF01230.23 EMC83929.1 - 0.1 13.3 0.4 0.41 11.4 0.1 2.0 2 1 0 2 2 2 0 HIT domain TIR_2 PF13676.6 EMC83930.1 - 2.7e-17 63.5 0.0 3.5e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 EMC83930.1 - 9.9e-09 35.2 0.0 1.3e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 TIR domain SIR2_2 PF13289.6 EMC83931.1 - 3.7e-20 72.5 0.1 8e-20 71.4 0.0 1.6 2 0 0 2 2 2 1 SIR2-like domain RFC1 PF08519.12 EMC83931.1 - 0.084 13.0 0.0 0.18 12.0 0.0 1.5 2 0 0 2 2 2 0 Replication factor RFC1 C terminal domain SRP-alpha_N PF04086.13 EMC83932.1 - 2e-57 195.3 8.6 2.6e-57 195.0 8.6 1.1 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54 PF00448.22 EMC83932.1 - 8.4e-35 120.2 0.6 1.4e-30 106.4 0.1 2.4 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain SRP54_N PF02881.19 EMC83932.1 - 4e-10 39.8 0.3 2.2e-09 37.4 0.1 2.3 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 EMC83932.1 - 0.00043 19.3 0.1 0.0012 17.9 0.1 1.6 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 EMC83932.1 - 0.077 13.2 0.8 1.2 9.3 0.4 2.7 2 1 0 2 2 2 0 AAA domain GNT-I PF03071.15 EMC83933.1 - 2e-150 501.4 0.0 1e-140 469.3 0.4 2.0 1 1 1 2 2 2 2 GNT-I family Glyco_tranf_2_3 PF13641.6 EMC83933.1 - 0.024 14.5 0.2 0.085 12.7 0.2 1.9 1 1 0 1 1 1 0 Glycosyltransferase like family 2 DnaJ PF00226.31 EMC83935.1 - 6.3e-29 99.9 4.6 9.5e-29 99.3 4.6 1.3 1 0 0 1 1 1 1 DnaJ domain Y_phosphatase PF00102.27 EMC83936.1 - 9.1e-78 261.1 0.1 1.3e-77 260.5 0.1 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EMC83936.1 - 0.0004 20.2 0.0 0.0009 19.1 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Tmemb_cc2 PF10267.9 EMC83936.1 - 0.0031 16.7 0.5 0.042 13.0 0.3 2.0 2 0 0 2 2 2 1 Predicted transmembrane and coiled-coil 2 protein Condensin2nSMC PF12422.8 EMC83937.1 - 2.5e-56 190.0 6.4 9.7e-56 188.1 1.4 3.7 3 0 0 3 3 3 1 Condensin II non structural maintenance of chromosomes subunit HEAT PF02985.22 EMC83937.1 - 1.7e-07 30.9 0.4 2.2 8.8 0.0 5.8 5 0 0 5 5 5 2 HEAT repeat DUF577 PF04510.12 EMC83937.1 - 0.0013 18.6 1.7 1.2 9.0 0.0 4.1 4 0 0 4 4 4 1 Family of unknown function (DUF577) HEAT_2 PF13646.6 EMC83937.1 - 0.0016 18.8 0.1 0.45 10.9 0.0 3.8 2 1 2 4 4 4 1 HEAT repeats DUF5389 PF17364.2 EMC83937.1 - 0.014 15.4 0.0 0.065 13.3 0.0 2.1 1 0 0 1 1 1 0 Family of unknown function (DUF5389) TIP120 PF08623.10 EMC83937.1 - 0.016 14.9 0.5 0.22 11.3 0.0 3.0 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) Vac14_Fab1_bd PF12755.7 EMC83937.1 - 0.027 15.1 1.2 0.2 12.3 0.0 3.2 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region PPR PF01535.20 EMC83937.1 - 0.14 12.5 0.1 0.85 10.0 0.1 2.4 1 0 0 1 1 1 0 PPR repeat PPR_1 PF12854.7 EMC83937.1 - 0.17 11.6 0.0 0.33 10.7 0.0 1.5 1 0 0 1 1 1 0 PPR repeat CARD PF00619.21 EMC83937.1 - 0.27 11.3 2.1 9.5 6.3 0.3 4.5 4 0 0 4 4 4 0 Caspase recruitment domain MgtE_N PF03448.17 EMC83937.1 - 0.39 11.3 3.8 2.5 8.8 0.2 3.9 5 0 0 5 5 5 0 MgtE intracellular N domain DUF1041 PF06292.17 EMC83937.1 - 2.5 8.6 5.8 4.9 7.6 0.5 3.7 4 0 0 4 4 4 0 Domain of Unknown Function (DUF1041) Pyr_redox_2 PF07992.14 EMC83939.1 - 5.3e-25 88.2 0.0 1.8e-23 83.2 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rubredoxin_C PF18267.1 EMC83939.1 - 5.8e-08 32.5 0.5 6.9e-07 29.1 0.0 2.4 2 0 0 2 2 2 1 Rubredoxin NAD+ reductase C-terminal domain Pyr_redox_3 PF13738.6 EMC83939.1 - 0.0088 15.3 0.7 2.1 7.5 0.0 3.5 3 2 1 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase Helicase_C PF00271.31 EMC83940.1 - 7.5e-18 64.9 0.0 9.6e-16 58.1 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EMC83940.1 - 8.5e-18 64.7 0.0 1.9e-17 63.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 EMC83940.1 - 3.2e-12 47.0 5.5 3.2e-12 47.0 5.5 2.4 2 0 0 2 2 2 1 RecQ zinc-binding ResIII PF04851.15 EMC83940.1 - 4.2e-05 23.6 0.4 9.1e-05 22.5 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit RQC PF09382.10 EMC83940.1 - 0.002 17.9 0.0 0.032 14.0 0.0 2.7 1 1 0 1 1 1 1 RQC domain Osmo_CC PF08946.10 EMC83940.1 - 1.1 9.5 6.5 2 8.7 5.4 2.0 2 0 0 2 2 2 0 Osmosensory transporter coiled coil DASH_Spc19 PF08287.11 EMC83940.1 - 3.3 7.6 11.1 0.18 11.7 1.7 2.4 2 0 0 2 2 2 0 Spc19 Got1 PF04178.12 EMC83941.1 - 1.8e-17 63.8 15.5 2.2e-17 63.5 15.5 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family Ac81 PF05820.11 EMC83941.1 - 0.18 11.4 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 Baculoviridae AC81 Aminotran_4 PF01063.19 EMC83942.1 - 3.6e-34 118.6 0.0 4.3e-34 118.3 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV SPC12 PF06645.13 EMC83944.1 - 1e-31 108.8 2.0 1.2e-31 108.6 2.0 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) MFS_1 PF07690.16 EMC83944.1 - 0.0038 16.2 0.0 0.0042 16.1 0.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily LapA_dom PF06305.11 EMC83944.1 - 0.88 9.4 4.0 15 5.5 0.7 2.2 1 1 1 2 2 2 0 Lipopolysaccharide assembly protein A domain Glyco_transf_8 PF01501.20 EMC83945.1 - 3.7e-57 193.8 0.1 4.3e-57 193.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 EMC83945.1 - 0.00019 21.0 0.0 0.00033 20.2 0.0 1.4 1 0 0 1 1 1 1 Glucosyltransferase 24 Glyco_tranf_2_3 PF13641.6 EMC83945.1 - 0.029 14.3 0.2 2.3 8.1 0.1 2.7 3 1 0 3 3 3 0 Glycosyltransferase like family 2 GN3L_Grn1 PF08701.11 EMC83946.1 - 4.6e-20 71.5 28.5 4.6e-20 71.5 28.5 3.5 3 1 1 4 4 4 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 EMC83946.1 - 6.3e-13 48.8 0.1 8.3e-11 42.0 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EMC83946.1 - 7.2e-07 28.9 0.0 3.5e-05 23.4 0.0 2.6 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EMC83946.1 - 0.011 15.6 9.7 0.03 14.2 2.2 2.8 2 1 0 2 2 2 0 RsgA GTPase Dynamin_N PF00350.23 EMC83946.1 - 0.012 15.6 0.0 0.012 15.6 0.0 3.5 3 1 0 3 3 3 0 Dynamin family MeaB PF03308.16 EMC83946.1 - 0.06 12.3 0.1 0.06 12.3 0.1 2.1 2 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF4407 PF14362.6 EMC83946.1 - 0.13 11.6 6.5 0.26 10.6 6.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Phage_Mu_F PF04233.14 EMC83946.1 - 6.4 7.6 8.3 0.44 11.3 2.8 1.9 2 0 0 2 2 2 0 Phage Mu protein F like protein UPF0640 PF15114.6 EMC83947.1 - 2.6e-35 120.0 2.9 2.9e-35 119.9 2.9 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0640 EF-hand_8 PF13833.6 EMC83948.1 - 6.7e-28 96.3 15.1 4.4e-15 55.2 0.4 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.6 EMC83948.1 - 2e-27 95.4 9.8 3.1e-16 59.6 6.4 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EMC83948.1 - 6.9e-26 87.8 23.9 3.6e-08 32.4 1.0 4.8 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 EMC83948.1 - 9.7e-21 71.9 15.4 3e-07 29.8 1.9 5.2 3 1 1 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EMC83948.1 - 2.5e-15 55.1 20.1 1.2e-06 27.7 0.3 4.9 4 1 1 5 5 5 3 EF hand EF-hand_9 PF14658.6 EMC83948.1 - 6.9e-13 48.7 1.0 3.9e-06 27.1 0.3 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EMC83948.1 - 1.4e-06 28.1 6.7 0.012 15.6 0.0 3.1 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EMC83948.1 - 4.5e-05 23.7 1.6 0.0019 18.5 0.4 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.13 EMC83948.1 - 0.00093 19.2 0.2 0.94 9.4 0.0 2.3 1 1 0 2 2 2 2 Tellurite resistance protein TerB DUF1707 PF08044.11 EMC83948.1 - 0.004 17.2 0.8 1.2 9.2 0.1 3.3 3 1 1 4 4 4 1 Domain of unknown function (DUF1707) UPF0154 PF03672.13 EMC83948.1 - 0.0063 16.5 0.0 1.9 8.5 0.0 2.4 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0154) DUF1456 PF07308.13 EMC83948.1 - 0.023 15.0 1.7 2.8 8.3 0.1 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1456) DUF5580 PF17743.1 EMC83948.1 - 0.024 13.2 0.0 0.03 12.9 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) EF-hand_10 PF14788.6 EMC83948.1 - 0.035 14.0 3.7 0.14 12.1 0.7 2.8 2 1 1 3 3 3 0 EF hand EMG1 PF03587.14 EMC83948.1 - 0.076 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 EMG1/NEP1 methyltransferase Syntaxin PF00804.25 EMC83948.1 - 0.35 10.5 2.9 2.4 7.8 0.3 2.3 2 1 0 2 2 2 0 Syntaxin Ribosomal_L29e PF01779.17 EMC83949.1 - 6.4e-18 64.8 1.4 6.4e-18 64.8 1.4 2.2 2 0 0 2 2 2 2 Ribosomal L29e protein family HSF_DNA-bind PF00447.17 EMC83950.1 - 1.1e-23 83.6 0.2 1.4e-23 83.4 0.2 1.1 1 0 0 1 1 1 1 HSF-type DNA-binding DSPc PF00782.20 EMC83951.1 - 3.8e-43 146.5 0.0 5.3e-43 146.0 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 EMC83951.1 - 0.00018 22.0 0.0 0.00035 21.1 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Y_phosphatase PF00102.27 EMC83951.1 - 0.00049 19.7 0.0 0.00077 19.1 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 EMC83951.1 - 0.0071 16.6 0.0 0.015 15.6 0.0 1.5 1 0 0 1 1 1 1 Rit1 DUSP-like domain PTPlike_phytase PF14566.6 EMC83951.1 - 0.021 14.9 0.0 0.051 13.7 0.0 1.6 2 0 0 2 2 2 0 Inositol hexakisphosphate WD40 PF00400.32 EMC83952.1 - 8e-66 216.4 19.8 1.5e-09 38.3 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC83952.1 - 6.6e-23 80.8 0.1 0.00056 20.1 0.0 6.6 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMC83952.1 - 1.1e-11 44.3 3.2 0.0063 15.5 0.1 5.0 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EMC83952.1 - 2.4e-10 40.6 0.2 9.5e-06 25.6 0.0 2.9 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Proteasome_A_N PF10584.9 EMC83952.1 - 0.0049 16.5 0.3 1 9.1 0.0 3.1 3 0 0 3 3 3 1 Proteasome subunit A N-terminal signature PD40 PF07676.12 EMC83952.1 - 0.041 13.8 1.6 2.2 8.3 0.0 3.5 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat WD40_like PF17005.5 EMC83952.1 - 0.045 13.1 0.0 16 4.7 0.0 3.8 1 1 1 4 4 4 0 WD40-like domain Syntaxin-6_N PF09177.11 EMC83952.1 - 0.094 13.3 1.9 0.18 12.4 1.9 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal CLZ PF16526.5 EMC83952.1 - 1.2 9.5 5.0 8.5 6.8 5.1 2.1 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Aminotran_1_2 PF00155.21 EMC83954.1 - 9.7e-71 238.8 0.0 1.6e-70 238.1 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class I and II Preseq_ALAS PF09029.10 EMC83954.1 - 1.4e-19 70.7 1.4 3.1e-19 69.6 1.4 1.6 1 0 0 1 1 1 1 5-aminolevulinate synthase presequence Cys_Met_Meta_PP PF01053.20 EMC83954.1 - 2.4e-07 29.6 0.0 1e-06 27.6 0.0 1.8 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EMC83954.1 - 1.8e-05 23.9 0.0 3.2e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EMC83954.1 - 0.00055 19.3 0.0 0.00094 18.5 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EMC83954.1 - 0.011 15.0 0.3 0.042 13.1 0.3 1.8 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Cofilin_ADF PF00241.20 EMC83955.1 - 2.7e-41 140.2 0.5 4.3e-22 78.2 0.6 2.8 3 0 0 3 3 3 2 Cofilin/tropomyosin-type actin-binding protein WD40 PF00400.32 EMC83955.1 - 5e-24 84.1 1.1 4.1e-05 24.3 0.0 6.7 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC83955.1 - 6.5e-14 52.0 0.0 0.00082 19.6 0.0 4.8 2 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain MinC_C PF03775.16 EMC83955.1 - 0.19 11.7 0.0 0.69 9.9 0.0 1.9 1 0 0 1 1 1 0 Septum formation inhibitor MinC, C-terminal domain PD40 PF07676.12 EMC83955.1 - 4 7.5 6.4 17 5.5 0.0 4.0 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat PP2C PF00481.21 EMC83956.1 - 1.3e-33 116.8 0.0 2.6e-15 56.7 0.0 2.8 2 1 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 EMC83956.1 - 3.7e-05 23.7 0.1 0.048 13.6 0.0 2.3 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 EMC83956.1 - 0.037 13.7 0.0 0.26 10.9 0.0 2.0 1 1 0 1 1 1 0 Protein phosphatase 2C DUF4147 PF13660.6 EMC83957.1 - 4.9e-75 252.0 0.9 7.6e-75 251.4 0.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4147) MOFRL PF05161.13 EMC83957.1 - 2e-37 127.7 1.0 4.1e-37 126.7 1.0 1.6 1 0 0 1 1 1 1 MOFRL family Peptidase_C12 PF01088.21 EMC83959.1 - 2.3e-63 213.7 0.0 5e-63 212.6 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 EMC83959.1 - 6.8e-17 61.1 0.1 1.8e-16 59.8 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases Nucleo_P87 PF07267.11 EMC83959.1 - 0.63 8.8 9.6 1 8.1 9.6 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Abhydrolase_6 PF12697.7 EMC83960.1 - 5.4e-09 37.0 2.0 2.5e-05 25.0 0.9 2.0 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EMC83960.1 - 1.4e-06 28.2 0.0 3.6e-05 23.5 0.0 2.0 1 1 1 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMC83960.1 - 0.0014 17.9 0.1 0.097 11.9 0.0 2.0 1 1 1 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 EMC83960.1 - 0.0065 16.0 0.0 0.0093 15.5 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.13 EMC83960.1 - 0.14 11.8 0.0 0.16 11.6 0.0 1.1 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.20 EMC83961.1 - 3.8e-11 43.1 0.0 0.0002 21.1 0.0 2.0 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMC83961.1 - 1.7e-07 32.1 1.4 0.00049 20.8 0.4 2.0 1 1 1 2 2 2 2 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMC83961.1 - 6.2e-05 22.4 0.0 0.081 12.2 0.0 2.4 1 1 1 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 EMC83961.1 - 0.0018 17.9 0.0 0.011 15.3 0.0 1.9 2 0 0 2 2 2 1 Dienelactone hydrolase family Peptidase_S15 PF02129.18 EMC83961.1 - 0.032 13.8 0.0 0.31 10.6 0.0 2.1 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) FSH1 PF03959.13 EMC83961.1 - 0.074 12.7 0.0 0.087 12.5 0.0 1.1 1 0 0 1 1 1 0 Serine hydrolase (FSH1) KH_1 PF00013.29 EMC83962.1 - 1e-49 166.2 12.8 1.4e-17 63.3 0.6 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EMC83962.1 - 1.4e-14 53.6 4.1 0.00011 21.9 0.0 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EMC83962.1 - 4.4e-08 32.9 1.2 0.0086 15.9 0.1 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 EMC83962.1 - 3.6e-05 23.8 4.8 1.3 9.2 0.2 3.4 3 0 0 3 3 3 3 NusA-like KH domain MOEP19 PF16005.5 EMC83962.1 - 0.00049 20.0 0.1 0.028 14.4 0.0 3.2 3 1 1 4 4 4 1 KH-like RNA-binding domain 7tm_1 PF00001.21 EMC83963.1 - 4.8e-39 134.3 22.5 6.1e-39 133.9 22.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC83963.1 - 0.0057 16.3 18.9 0.0057 16.3 18.9 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx PARP PF00644.20 EMC83964.1 - 5.1e-24 85.0 0.0 7.1e-24 84.5 0.0 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Sema PF01403.19 EMC83965.1 - 4e-141 470.7 0.0 5.2e-141 470.3 0.0 1.1 1 0 0 1 1 1 1 Sema domain PSI PF01437.25 EMC83965.1 - 0.00081 19.9 8.3 0.0029 18.1 8.3 2.0 1 0 0 1 1 1 1 Plexin repeat G-alpha PF00503.20 EMC83966.1 - 3.2e-120 401.5 1.8 3.9e-120 401.2 1.8 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EMC83966.1 - 2.3e-14 53.2 2.6 1.1e-10 41.3 0.3 2.7 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EMC83966.1 - 0.00055 19.4 0.6 0.55 9.6 0.1 2.5 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EMC83966.1 - 0.0019 18.4 1.0 1.5 9.1 0.1 2.7 1 1 2 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 EMC83966.1 - 0.034 13.6 0.0 0.052 13.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein DAP3 PF10236.9 EMC83966.1 - 0.11 11.6 0.4 0.17 11.0 0.4 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_29 PF13555.6 EMC83966.1 - 0.11 12.2 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain G-alpha PF00503.20 EMC83967.1 - 9.6e-118 393.4 3.2 1.1e-117 393.2 3.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EMC83967.1 - 7.7e-14 51.5 0.1 9.2e-13 48.0 0.1 2.5 2 0 0 2 2 2 1 ADP-ribosylation factor family Sema PF01403.19 EMC83968.1 - 4.4e-151 503.5 0.0 8.9e-151 502.5 0.0 1.5 1 1 0 1 1 1 1 Sema domain PSI PF01437.25 EMC83968.1 - 0.0015 19.1 6.1 0.0015 19.1 6.1 2.4 3 0 0 3 3 3 1 Plexin repeat OAS1_C PF10421.9 EMC83969.1 - 2.1e-66 222.9 0.1 5.1e-66 221.7 0.0 1.6 2 0 0 2 2 2 1 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus ubiquitin PF00240.23 EMC83969.1 - 3.3e-30 103.6 0.5 6.7e-20 70.6 0.0 2.7 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EMC83969.1 - 5.2e-11 42.2 0.1 4.3e-08 32.9 0.0 2.6 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EMC83969.1 - 7.2e-11 42.4 0.4 1.5e-05 25.4 0.1 2.6 2 0 0 2 2 2 2 Ubiquitin-like domain NTP_transf_2 PF01909.23 EMC83969.1 - 4.5e-07 30.1 0.0 1.2e-06 28.8 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain SMODS PF18144.1 EMC83969.1 - 0.00067 19.9 0.0 0.002 18.3 0.0 1.8 2 0 0 2 2 2 1 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain UN_NPL4 PF11543.8 EMC83969.1 - 0.0091 16.5 0.0 0.22 12.0 0.0 2.5 2 0 0 2 2 2 1 Nuclear pore localisation protein NPL4 Ubiquitin_4 PF18036.1 EMC83969.1 - 0.028 14.5 0.2 3.3 7.8 0.0 3.2 2 2 0 2 2 2 0 Ubiquitin-like domain IFRD PF05004.13 EMC83970.1 - 3e-84 282.7 0.2 3.6e-84 282.5 0.2 1.1 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) IFRD_C PF04836.12 EMC83970.1 - 4.4e-23 81.6 3.6 1.7e-22 79.7 0.4 2.4 2 0 0 2 2 2 1 Interferon-related protein conserved region WD40 PF00400.32 EMC83971.1 - 1.2e-22 79.7 13.1 3.1e-06 27.8 0.7 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat HPS3_N PF14761.6 EMC83971.1 - 0.031 13.8 0.0 0.051 13.1 0.0 1.3 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 ANF_receptor PF01094.28 EMC83972.1 - 2.1e-100 336.3 0.0 2.6e-100 336.0 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.22 EMC83972.1 - 3.3e-61 207.1 16.8 5.2e-61 206.4 16.8 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.14 EMC83972.1 - 1.8e-12 47.0 10.4 1.8e-12 47.0 10.4 2.6 2 0 0 2 2 2 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.6 EMC83972.1 - 3.8e-09 36.7 0.5 6.6e-09 35.9 0.5 1.2 1 0 0 1 1 1 1 Periplasmic binding protein DUF543 PF04418.12 EMC83972.1 - 0.01 15.8 0.3 1.3 9.1 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF543) CoA_binding_2 PF13380.6 EMC83972.1 - 0.18 12.3 0.0 0.34 11.4 0.0 1.4 1 0 0 1 1 1 0 CoA binding domain IQ PF00612.27 EMC83973.1 - 1.3e-08 33.9 3.7 6.4e-07 28.6 0.5 4.9 5 0 0 5 5 5 3 IQ calmodulin-binding motif Unstab_antitox PF09720.10 EMC83973.1 - 2.5 8.2 7.0 0.29 11.2 0.5 2.3 1 1 1 2 2 2 0 Putative addiction module component Ras PF00071.22 EMC83974.1 - 1.6e-57 193.6 0.0 1.9e-57 193.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC83974.1 - 2.7e-23 82.5 0.0 3.7e-23 82.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC83974.1 - 1e-09 38.1 0.0 1.9e-09 37.2 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC83974.1 - 0.0006 19.4 0.0 0.0012 18.4 0.0 1.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EMC83974.1 - 0.035 13.5 0.0 0.064 12.7 0.0 1.4 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EMC83974.1 - 0.051 12.9 0.0 0.069 12.5 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region GSHPx PF00255.19 EMC83975.1 - 1.1e-09 37.8 0.0 1.7e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione peroxidase EMC3_TMCO1 PF01956.16 EMC83976.1 - 2.7e-36 124.9 4.7 4.6e-36 124.1 0.4 2.1 2 0 0 2 2 2 2 Integral membrane protein EMC3/TMCO1-like FancD2 PF14631.6 EMC83977.1 - 0 2295.1 22.4 0 2294.7 22.4 1.1 1 0 0 1 1 1 1 Fanconi anaemia protein FancD2 nuclease FANCI_S2 PF14676.6 EMC83977.1 - 0.00023 21.5 0.3 0.00023 21.5 0.3 4.2 4 1 0 5 5 5 1 FANCI solenoid 2 Peptidase_S9 PF00326.21 EMC83978.1 - 2.5e-25 89.2 0.0 3.3e-25 88.8 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EMC83978.1 - 1.9e-11 43.7 0.0 2.7e-05 23.5 0.0 2.2 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMC83978.1 - 1.9e-10 40.9 0.0 1.2e-08 34.9 0.0 2.2 1 1 1 2 2 2 1 alpha/beta hydrolase fold DLH PF01738.18 EMC83978.1 - 5.7e-06 26.0 0.0 1.4e-05 24.7 0.0 1.5 2 0 0 2 2 2 1 Dienelactone hydrolase family Peptidase_S15 PF02129.18 EMC83978.1 - 0.00057 19.6 0.0 1.3 8.5 0.0 2.4 2 0 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_3 PF07859.13 EMC83978.1 - 0.00074 19.4 0.2 0.002 18.0 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Esterase PF00756.20 EMC83978.1 - 0.0089 15.7 0.0 0.018 14.7 0.0 1.5 1 0 0 1 1 1 1 Putative esterase BAAT_C PF08840.11 EMC83978.1 - 0.026 14.5 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.13 EMC83978.1 - 0.17 11.5 0.0 0.29 10.8 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Kringle PF00051.18 EMC83979.1 - 1.3e-90 297.8 38.9 6e-29 100.2 3.4 4.4 4 0 0 4 4 4 4 Kringle domain Trypsin PF00089.26 EMC83979.1 - 3.7e-22 79.2 0.0 7e-22 78.3 0.0 1.4 1 0 0 1 1 1 1 Trypsin PAN_1 PF00024.26 EMC83979.1 - 3.7e-10 39.6 0.2 1.1e-09 38.1 0.2 1.8 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.6 EMC83979.1 - 0.00051 19.9 2.8 0.0029 17.5 0.5 3.1 2 0 0 2 2 2 1 PAN domain PAN_2 PF08276.11 EMC83979.1 - 0.086 13.0 5.8 0.15 12.2 0.1 2.8 2 0 0 2 2 2 0 PAN-like domain ThiF PF00899.21 EMC83981.1 - 1.7e-83 279.7 0.0 1.8e-60 204.4 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 EMC83981.1 - 3.1e-77 259.9 0.0 4.1e-77 259.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 EMC83981.1 - 1.1e-24 86.4 0.0 1.9e-24 85.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 EMC83981.1 - 5.6e-17 61.7 0.9 1.5e-16 60.3 0.1 2.2 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 four-helix bundle Pyr_redox_2 PF07992.14 EMC83981.1 - 0.13 11.5 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase IPK PF03770.16 EMC83982.1 - 1.1e-63 214.7 0.0 1.6e-63 214.1 0.0 1.2 1 0 0 1 1 1 1 Inositol polyphosphate kinase NTP_transferase PF00483.23 EMC83983.1 - 4.3e-22 78.9 0.0 8.3e-22 78.0 0.0 1.4 2 0 0 2 2 2 1 Nucleotidyl transferase Hexapep PF00132.24 EMC83983.1 - 1.7e-08 33.9 5.4 1.7e-08 33.9 5.4 3.5 1 1 2 3 3 3 1 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EMC83983.1 - 2.9e-05 23.7 3.2 2.9e-05 23.7 3.2 3.2 4 0 0 4 4 4 1 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 EMC83983.1 - 0.025 12.8 0.7 0.036 12.2 0.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4954) SPRY PF00622.28 EMC83984.1 - 1.7e-26 92.6 0.1 3.5e-26 91.7 0.1 1.5 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_3 PF13920.6 EMC83984.1 - 3.7e-07 29.9 9.7 3.7e-07 29.9 9.7 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC83984.1 - 0.0012 19.2 11.7 0.003 17.9 11.7 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EMC83984.1 - 0.016 15.1 14.0 0.044 13.7 14.0 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC83984.1 - 0.027 14.4 9.9 0.08 12.9 9.9 1.9 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EMC83984.1 - 1.5 8.7 18.2 0.058 13.3 12.2 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC83984.1 - 4.2 7.3 16.4 1.5 8.7 11.9 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EMC83984.1 - 4.7 7.3 12.0 11 6.2 12.0 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EMC83984.1 - 6.7 7.0 10.7 19 5.5 10.7 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING LRR_8 PF13855.6 EMC83985.1 - 5.1e-28 96.6 13.5 1.3e-15 56.9 2.1 3.7 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EMC83985.1 - 2.4e-18 65.9 25.8 1.3e-05 25.4 0.2 4.7 1 1 5 6 6 6 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC83985.1 - 1.2e-12 46.5 11.3 0.3 11.8 0.1 7.7 8 0 0 8 8 8 5 Leucine Rich Repeat LRR_6 PF13516.6 EMC83985.1 - 8e-11 41.1 5.6 0.063 13.4 0.0 5.7 5 0 0 5 5 5 3 Leucine Rich repeat LRR_5 PF13306.6 EMC83985.1 - 3.5e-07 30.2 0.0 9.2e-07 28.9 0.0 1.7 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC83985.1 - 3.2e-05 23.5 0.4 0.0063 16.0 0.1 2.2 1 1 1 2 2 2 2 Leucine-rich repeat Ig_3 PF13927.6 EMC83985.1 - 0.00036 21.1 0.0 0.00083 19.9 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC83985.1 - 0.061 13.5 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain zf-HC5HC2H PF13771.6 EMC83986.1 - 2.2e-16 59.9 2.7 2.2e-16 59.9 2.7 3.2 3 2 0 3 3 3 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EMC83986.1 - 2.6e-09 37.2 3.9 2.6e-09 37.2 3.9 2.9 2 1 1 3 3 3 1 PHD-zinc-finger like domain zf-RING_2 PF13639.6 EMC83986.1 - 9.1e-06 25.9 8.2 9.1e-06 25.9 8.2 4.4 4 2 0 4 4 4 2 Ring finger domain zf-RING_11 PF17123.5 EMC83986.1 - 0.0026 17.5 3.1 0.0026 17.5 3.1 3.5 3 1 0 3 3 3 1 RING-like zinc finger PPTA PF01239.22 EMC83986.1 - 0.88 9.4 3.1 0.92 9.3 0.0 2.3 2 0 0 2 2 2 0 Protein prenyltransferase alpha subunit repeat Shisa PF13908.6 EMC83987.1 - 1e-07 32.4 7.0 1e-07 32.4 7.0 2.0 1 1 1 2 2 2 1 Wnt and FGF inhibitory regulator BTG PF07742.12 EMC83988.1 - 3.2e-28 97.9 0.0 4.3e-28 97.5 0.0 1.2 1 0 0 1 1 1 1 BTG family Ins_P5_2-kin PF06090.12 EMC83989.1 - 1e-90 304.6 0.4 1.2e-90 304.4 0.4 1.0 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase zf-C3HC4 PF00097.25 EMC83989.1 - 0.16 11.9 1.7 0.61 10.0 1.7 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) LRR_8 PF13855.6 EMC83990.1 - 9.3e-51 169.4 23.6 2.1e-16 59.4 0.1 6.5 4 1 3 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 EMC83990.1 - 1.1e-30 105.2 26.5 2e-05 24.8 1.2 8.5 5 1 3 9 9 9 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC83990.1 - 3.7e-12 45.0 25.3 8.5 7.4 0.0 11.8 11 1 0 11 11 11 3 Leucine Rich Repeat VWC PF00093.18 EMC83990.1 - 3.7e-11 43.2 13.4 9.3e-11 41.9 13.4 1.7 1 0 0 1 1 1 1 von Willebrand factor type C domain LRR_5 PF13306.6 EMC83990.1 - 3.3e-10 40.0 0.2 6e-05 23.0 0.0 3.3 2 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC83990.1 - 1.5e-09 37.6 10.3 8.3e-05 22.2 0.5 4.9 1 1 4 5 5 5 4 Leucine-rich repeat LRR_6 PF13516.6 EMC83990.1 - 9.8e-07 28.4 22.0 0.13 12.4 0.0 9.6 11 0 0 11 11 11 2 Leucine Rich repeat LRRNT PF01462.18 EMC83990.1 - 0.0007 19.2 5.3 0.024 14.3 0.1 4.0 4 0 0 4 4 4 1 Leucine rich repeat N-terminal domain Amnionless PF14828.6 EMC83990.1 - 0.017 14.0 9.2 0.027 13.3 9.2 1.2 1 0 0 1 1 1 0 Amnionless Rrn6 PF10214.9 EMC83990.1 - 0.078 11.5 0.0 0.16 10.4 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor FNIP PF05725.12 EMC83990.1 - 0.17 12.1 12.2 7.4 6.8 0.3 4.7 4 1 0 4 4 4 0 FNIP Repeat LRR_8 PF13855.6 EMC83991.1 - 2.2e-72 238.7 46.7 4e-13 48.9 1.6 9.6 6 4 3 9 9 9 9 Leucine rich repeat LRR_4 PF12799.7 EMC83991.1 - 1.1e-34 117.9 59.1 0.00025 21.4 0.4 12.2 4 3 9 13 13 13 12 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC83991.1 - 2.5e-19 69.5 6.9 4.1e-07 30.0 0.0 5.4 2 2 1 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC83991.1 - 8.7e-16 57.9 26.2 8e-05 22.2 1.3 5.9 3 2 3 6 6 6 5 Leucine-rich repeat LRRNT PF01462.18 EMC83991.1 - 1.2e-11 43.9 22.5 3e-07 29.9 1.6 6.1 7 0 0 7 7 7 2 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 EMC83991.1 - 1.6e-07 30.9 44.0 1.7 9.5 0.1 15.5 15 2 1 16 16 16 2 Leucine Rich Repeat LRR_6 PF13516.6 EMC83991.1 - 0.0012 18.7 36.0 7.5 6.9 0.1 12.0 14 0 0 14 14 14 4 Leucine Rich repeat LRR_8 PF13855.6 EMC83992.1 - 4e-20 71.3 2.2 4.8e-08 32.6 0.0 3.6 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EMC83992.1 - 3.6e-13 49.5 8.0 9.9e-05 22.6 0.1 4.1 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC83992.1 - 1.4e-05 25.1 0.2 0.11 12.4 0.0 2.3 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EMC83992.1 - 2.3e-05 24.3 5.9 4.5 8.2 0.1 5.9 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_6 PF13516.6 EMC83992.1 - 0.00043 20.1 1.2 2.7 8.3 0.0 4.7 5 0 0 5 5 5 1 Leucine Rich repeat LRR_9 PF14580.6 EMC83992.1 - 0.005 16.4 1.6 0.39 10.2 0.0 2.3 1 1 1 2 2 2 2 Leucine-rich repeat CENP-P PF13096.6 EMC83993.1 - 2.3e-34 118.6 1.0 2.3e-34 118.6 1.0 1.5 2 0 0 2 2 2 1 CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P OmpH PF03938.14 EMC83993.1 - 0.019 15.3 0.6 0.029 14.7 0.6 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) EFG_IV PF03764.18 EMC83993.1 - 0.052 13.3 0.0 0.099 12.4 0.0 1.4 1 0 0 1 1 1 0 Elongation factor G, domain IV T6PP_N PF18572.1 EMC83993.1 - 0.082 12.7 3.4 0.16 11.8 2.1 2.2 1 1 1 2 2 2 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain Cep57_CLD_2 PF14197.6 EMC83993.1 - 0.18 11.9 6.6 5 7.3 1.2 2.4 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 tRNA-synt_1 PF00133.22 EMC83994.1 - 2.7e-243 808.7 0.0 8.2e-243 807.1 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EMC83994.1 - 3e-25 89.0 0.2 9.4e-25 87.3 0.1 1.9 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EMC83994.1 - 4.3e-14 52.1 0.5 0.00046 19.1 0.0 4.2 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EMC83994.1 - 0.013 14.8 0.0 0.06 12.7 0.0 2.1 3 0 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain SNF PF00209.18 EMC83995.1 - 1.1e-247 822.9 38.0 1.3e-247 822.6 38.0 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family SNF PF00209.18 EMC83996.1 - 7.3e-234 777.3 41.2 8.4e-234 777.1 41.2 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family 7tm_1 PF00001.21 EMC83997.1 - 2.1e-70 237.1 1.1 2.8e-70 236.7 1.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC83997.1 - 4.9e-10 39.2 16.3 5.2e-06 26.0 9.8 2.3 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC83997.1 - 1.8e-07 31.2 12.8 4.9e-07 29.8 8.7 2.3 2 1 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC83997.1 - 4.9e-07 29.6 10.0 4.9e-07 29.6 10.0 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Srg PF02118.21 EMC83997.1 - 0.00023 20.9 6.5 0.00023 20.9 6.5 2.8 2 1 1 3 3 3 1 Srg family chemoreceptor MAR_sialic_bdg PF10564.9 EMC83997.1 - 0.022 14.8 0.4 0.074 13.1 0.4 1.9 1 0 0 1 1 1 0 Sialic-acid binding micronemal adhesive repeat S_4TM PF18159.1 EMC83997.1 - 0.026 13.8 0.1 0.026 13.8 0.1 2.3 3 1 1 4 4 4 0 SMODS-associating 4TM effector domain DUF996 PF06195.13 EMC83997.1 - 0.68 10.2 11.4 0.12 12.7 0.4 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF996) Ninjurin PF04923.12 EMC83998.1 - 5.2e-37 125.9 7.3 5.9e-37 125.7 7.3 1.0 1 0 0 1 1 1 1 Ninjurin DUF4231 PF14015.6 EMC83998.1 - 0.37 11.3 2.0 0.69 10.4 1.0 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF4231) Neur_chan_memb PF02932.16 EMC83998.1 - 0.6 10.1 3.6 0.19 11.8 0.6 1.5 1 1 1 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region CARD PF00619.21 EMC84000.1 - 1.5e-07 31.3 0.3 2.6e-07 30.6 0.3 1.5 1 0 0 1 1 1 1 Caspase recruitment domain Cytokin_check_N PF10407.9 EMC84000.1 - 0.01 15.8 2.4 2 8.4 0.5 2.4 2 1 0 2 2 2 0 Cdc14 phosphatase binding protein N-terminus NADH5_C PF06455.11 EMC84000.1 - 0.095 12.3 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 NADH dehydrogenase subunit 5 C-terminus Sushi PF00084.20 EMC84001.1 - 4.8e-05 23.9 0.2 7.3e-05 23.3 0.2 1.3 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) CYYR1 PF10873.8 EMC84001.1 - 0.026 15.0 0.2 0.038 14.4 0.2 1.3 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 DUF728 PF05304.12 EMC84001.1 - 0.05 13.5 0.1 0.071 13.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF728) TraL PF07178.11 EMC84001.1 - 0.09 13.2 0.0 0.15 12.5 0.0 1.4 1 0 0 1 1 1 0 TraL protein EphA2_TM PF14575.6 EMC84001.1 - 0.13 13.1 0.1 0.21 12.5 0.1 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain RhoGEF PF00621.20 EMC84002.1 - 2.9e-47 161.3 0.6 2.9e-47 161.3 0.6 2.2 2 1 0 2 2 2 1 RhoGEF domain PH PF00169.29 EMC84002.1 - 2e-22 79.7 0.2 3.1e-13 50.1 0.0 2.6 2 0 0 2 2 2 2 PH domain FYVE PF01363.21 EMC84002.1 - 1.5e-14 53.9 13.8 2.6e-13 49.9 14.5 2.5 2 0 0 2 2 2 1 FYVE zinc finger PH_13 PF16652.5 EMC84002.1 - 0.00011 22.0 1.3 0.073 12.9 2.1 2.9 2 1 0 2 2 2 2 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 EMC84002.1 - 0.00033 20.6 1.6 0.00048 20.1 0.5 1.8 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 EMC84002.1 - 0.018 15.4 0.7 1.9 8.9 0.1 3.0 2 1 0 2 2 2 0 Pleckstrin homology domain PH_9 PF15410.6 EMC84002.1 - 0.024 15.0 2.3 3.7 8.0 0.1 3.2 3 0 0 3 3 3 0 Pleckstrin homology domain PH_16 PF17838.1 EMC84002.1 - 0.06 13.2 1.5 0.17 11.8 0.1 2.2 2 0 0 2 2 2 0 PH domain FYVE_2 PF02318.16 EMC84002.1 - 0.96 9.7 22.7 0.054 13.7 12.9 3.1 3 0 0 3 3 3 0 FYVE-type zinc finger MHC_I_3 PF16497.5 EMC84003.1 - 2.1e-26 92.7 0.3 2.6e-26 92.3 0.3 1.1 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.15 EMC84003.1 - 8.1e-18 64.6 0.0 2.4e-17 63.1 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin C1-set domain MHC_I PF00129.18 EMC84003.1 - 2.7e-09 36.9 0.0 3.5e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Ig_2 PF13895.6 EMC84003.1 - 4.7e-05 23.6 0.0 0.00014 22.1 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 EMC84003.1 - 0.00021 21.8 0.0 0.00048 20.7 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 EMC84003.1 - 0.004 17.2 0.0 0.0076 16.3 0.0 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain I-set PF07679.16 EMC84003.1 - 0.0095 16.0 0.0 0.022 14.8 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain MHC_I_3 PF16497.5 EMC84004.1 - 2.3e-25 89.3 0.0 2.9e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.15 EMC84004.1 - 1.4e-17 63.9 0.0 2.4e-17 63.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_2 PF13895.6 EMC84004.1 - 6.9e-05 23.1 0.0 0.00014 22.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC84004.1 - 0.00028 21.4 0.0 0.00047 20.7 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 EMC84004.1 - 0.0044 17.0 0.0 0.0074 16.3 0.0 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain I-set PF07679.16 EMC84004.1 - 0.012 15.7 0.0 0.021 14.9 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain ig PF00047.25 EMC84004.1 - 0.18 12.0 0.0 0.66 10.2 0.0 1.9 2 1 0 2 2 2 0 Immunoglobulin domain MHC_I_3 PF16497.5 EMC84005.1 - 3.3e-24 85.5 0.0 4.2e-24 85.1 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.15 EMC84005.1 - 1.5e-17 63.7 0.0 2.7e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.18 EMC84005.1 - 2e-07 30.8 0.0 2.8e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Ig_2 PF13895.6 EMC84005.1 - 7.5e-05 23.0 0.0 0.00015 22.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC84005.1 - 0.00033 21.2 0.0 0.00053 20.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 EMC84005.1 - 0.0054 16.8 0.0 0.0085 16.1 0.0 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain I-set PF07679.16 EMC84005.1 - 0.014 15.5 0.0 0.024 14.7 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain DAGK_acc PF00609.19 EMC84006.1 - 5.9e-48 163.2 0.0 8.8e-48 162.6 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain Ank_2 PF12796.7 EMC84006.1 - 1.5e-13 51.1 0.3 3e-13 50.2 0.3 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC84006.1 - 1.4e-09 38.0 0.0 0.00027 21.1 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC84006.1 - 2.3e-09 37.6 0.0 6.7e-07 29.7 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC84006.1 - 2.2e-08 33.7 1.8 0.0039 17.6 0.0 3.4 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 EMC84006.1 - 4.1e-07 30.2 0.9 0.011 16.1 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat PTN_MK_N PF05196.13 EMC84007.1 - 2.1e-26 91.9 17.0 2.1e-26 91.9 17.0 2.2 3 0 0 3 3 3 1 PTN/MK heparin-binding protein family, N-terminal domain PTN_MK_C PF01091.18 EMC84007.1 - 9.7e-26 89.9 4.5 9.7e-26 89.9 4.5 2.9 2 1 1 3 3 3 1 PTN/MK heparin-binding protein family, C-terminal domain 7tm_1 PF00001.21 EMC84008.1 - 1.6e-73 247.3 7.0 2.3e-73 246.8 7.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC84008.1 - 1.7e-06 27.8 12.2 1.7e-06 27.8 12.2 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC84008.1 - 5.3e-06 26.4 5.5 5.3e-06 26.4 5.5 2.6 2 1 0 3 3 3 1 Olfactory receptor OGFr_III PF04680.13 EMC84009.1 - 0.031 14.9 1.8 0.045 14.3 1.8 1.2 1 0 0 1 1 1 0 Opioid growth factor receptor repeat FAM60A PF15396.6 EMC84009.1 - 2.1 8.3 35.6 3.2 7.7 35.6 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Trypan_PARP PF05887.11 EMC84009.1 - 3.6 7.6 54.5 0.7 9.9 33.0 2.0 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) SLC12 PF03522.15 EMC84009.1 - 4.3 6.2 36.6 5.2 6.0 36.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Ank_4 PF13637.6 EMC84010.1 - 2.2e-19 69.5 0.1 7e-12 45.6 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC84010.1 - 2e-17 63.0 0.0 1.7e-10 40.9 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC84010.1 - 2.3e-16 60.1 0.1 1.2e-15 57.8 0.0 2.1 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC84010.1 - 2.7e-14 51.9 0.0 1e-06 28.6 0.0 3.3 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 EMC84010.1 - 1.4e-13 50.6 0.1 1.3e-06 28.6 0.0 2.7 3 0 0 3 3 3 2 Ankyrin repeat DUF655 PF04919.12 EMC84010.1 - 0.12 12.3 0.0 0.13 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF655) Glyco_transf_8 PF01501.20 EMC84011.1 - 3.5e-51 174.2 0.0 4.3e-51 173.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 EMC84011.1 - 0.00017 21.1 0.1 0.00033 20.2 0.1 1.5 1 1 0 1 1 1 1 Glucosyltransferase 24 CBFD_NFYB_HMF PF00808.23 EMC84012.1 - 3.9e-29 100.7 0.6 5.9e-29 100.2 0.6 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EMC84012.1 - 6.2e-06 26.6 0.0 9.6e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.16 EMC84012.1 - 0.0014 18.6 0.0 0.0022 18.0 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit CENP-T_C PF15511.6 EMC84012.1 - 0.0031 17.6 0.0 0.0048 17.0 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID_20kDa PF03847.13 EMC84012.1 - 0.12 12.9 0.0 0.21 12.1 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Bromo_TP PF07524.13 EMC84012.1 - 0.13 12.3 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Bromodomain associated Pyr_redox_2 PF07992.14 EMC84013.1 - 8e-55 186.1 0.1 9.8e-55 185.8 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EMC84013.1 - 6e-28 97.3 0.0 2.3e-27 95.4 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EMC84013.1 - 8e-19 68.0 3.1 1.4e-15 57.6 0.2 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMC84013.1 - 2.1e-16 60.1 0.1 1.3e-12 47.6 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMC84013.1 - 8.7e-06 25.1 0.3 2.5e-05 23.5 0.2 1.8 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EMC84013.1 - 2.8e-05 23.0 0.1 0.00048 19.0 0.1 2.1 2 0 0 2 2 2 1 HI0933-like protein AlaDh_PNT_C PF01262.21 EMC84013.1 - 5.2e-05 22.6 0.0 0.023 14.0 0.0 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 EMC84013.1 - 0.00039 19.9 0.9 0.00064 19.2 0.9 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 EMC84013.1 - 0.0025 17.0 0.2 0.0048 16.0 0.2 1.5 1 0 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.17 EMC84013.1 - 0.0032 16.7 1.2 0.0037 16.5 0.1 1.6 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 EMC84013.1 - 0.0099 16.1 0.3 0.0099 16.1 0.3 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMC84013.1 - 0.029 13.9 0.1 0.068 12.7 0.0 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 EMC84013.1 - 0.044 14.2 1.1 3.1 8.3 0.0 2.7 3 0 0 3 3 3 0 Putative NAD(P)-binding Lycopene_cycl PF05834.12 EMC84013.1 - 0.14 11.2 0.1 0.22 10.5 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Kelch_1 PF01344.25 EMC84013.1 - 0.15 11.7 0.0 0.15 11.7 0.0 1.8 2 0 0 2 2 1 0 Kelch motif Ank_4 PF13637.6 EMC84015.1 - 2.6e-30 104.4 5.8 9.6e-12 45.2 0.1 4.0 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EMC84015.1 - 1.7e-29 100.9 4.7 8.8e-07 29.1 0.3 4.1 4 0 0 4 4 4 4 Ankyrin repeat Ank_2 PF12796.7 EMC84015.1 - 2.3e-29 101.8 1.3 1.5e-13 51.2 0.2 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC84015.1 - 1.3e-27 95.5 10.8 9.4e-10 38.6 0.4 4.0 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC84015.1 - 4.2e-27 91.2 1.7 5.2e-05 23.3 0.1 4.1 4 0 0 4 4 4 4 Ankyrin repeat DnaJ PF00226.31 EMC84016.1 - 2.6e-28 97.9 2.2 4.6e-28 97.1 2.2 1.4 1 0 0 1 1 1 1 DnaJ domain 7tm_1 PF00001.21 EMC84017.1 - 5.3e-40 137.4 24.4 6.6e-40 137.1 24.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC84017.1 - 0.00085 18.8 24.6 0.0018 17.7 24.6 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Patatin PF01734.22 EMC84018.1 - 9.6e-24 84.7 0.0 1.8e-22 80.6 0.0 2.7 3 0 0 3 3 3 1 Patatin-like phospholipase DUF1664 PF07889.12 EMC84018.1 - 0.038 14.0 0.3 0.14 12.2 0.3 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) COG2 PF06148.11 EMC84018.1 - 0.21 11.7 0.1 0.21 11.7 0.1 2.2 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF3683 PF12447.8 EMC84018.1 - 5.2 7.2 9.6 7.3 6.7 0.5 3.5 4 1 0 4 4 4 0 Protein of unknown function (DUF3683) Ig_3 PF13927.6 EMC84019.1 - 6.7e-76 250.9 1.5 1e-12 48.4 0.2 7.5 7 0 0 7 7 7 6 Immunoglobulin domain I-set PF07679.16 EMC84019.1 - 2.2e-70 232.7 0.0 1.9e-12 47.0 0.0 6.9 6 0 0 6 6 6 6 Immunoglobulin I-set domain fn3 PF00041.21 EMC84019.1 - 4.3e-63 209.7 15.5 2.7e-14 53.3 0.1 5.5 5 0 0 5 5 5 5 Fibronectin type III domain Ig_2 PF13895.6 EMC84019.1 - 9.1e-48 160.5 0.3 4e-08 33.5 0.0 6.5 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.25 EMC84019.1 - 4.3e-44 148.6 0.0 1e-07 32.0 0.0 6.8 6 0 0 6 6 6 6 Immunoglobulin domain Bravo_FIGEY PF13882.6 EMC84019.1 - 3.1e-26 92.5 6.7 6.7e-26 91.5 6.7 1.6 1 0 0 1 1 1 1 Bravo-like intracellular region V-set PF07686.17 EMC84019.1 - 1.7e-13 50.6 2.7 0.086 13.0 0.0 9.0 7 3 0 7 7 7 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC84019.1 - 5.8e-12 45.5 0.1 0.091 12.8 0.0 6.2 6 0 0 6 6 6 3 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 EMC84019.1 - 2.1e-09 36.8 0.2 0.57 9.8 0.0 5.8 6 0 0 6 6 6 3 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 EMC84019.1 - 3.9e-07 30.5 2.2 0.049 14.2 0.0 5.6 5 0 0 5 5 5 1 Purple acid Phosphatase, N-terminal domain Ig_5 PF16681.5 EMC84019.1 - 1.6e-06 28.4 0.0 0.57 10.6 0.0 5.4 6 1 0 6 6 5 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 EMC84019.1 - 3.6e-06 27.1 0.1 5 7.5 0.0 5.4 6 0 0 6 6 5 2 T-cell surface glycoprotein CD3 delta chain V-set_CD47 PF08204.11 EMC84019.1 - 0.00059 19.8 1.4 5.8 6.9 0.0 3.8 4 0 0 4 4 4 1 CD47 immunoglobulin-like domain Izumo-Ig PF16706.5 EMC84019.1 - 0.00094 19.2 0.1 1.5 8.9 0.0 3.7 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Interfer-bind PF09294.10 EMC84019.1 - 0.0012 19.1 0.2 27 5.1 0.0 4.8 6 0 0 6 6 5 0 Interferon-alpha/beta receptor, fibronectin type III SIT PF15330.6 EMC84019.1 - 0.0013 19.1 0.0 0.085 13.3 0.0 2.5 2 0 0 2 2 2 1 SHP2-interacting transmembrane adaptor protein, SIT Adeno_E3_CR1 PF02440.15 EMC84019.1 - 0.0021 17.8 2.9 0.21 11.4 0.0 4.3 5 0 0 5 5 4 1 Adenovirus E3 region protein CR1 PT PF04886.12 EMC84020.1 - 5.7e-06 25.8 6.9 0.028 13.9 0.5 3.7 2 1 1 3 3 3 3 PT repeat Ank_2 PF12796.7 EMC84021.1 - 5.7e-88 289.6 12.4 1.1e-16 61.1 0.0 8.1 1 1 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC84021.1 - 1.6e-69 229.5 17.3 9.9e-11 42.0 0.1 11.2 5 2 6 12 12 12 10 Ankyrin repeats (many copies) Ank PF00023.30 EMC84021.1 - 9.1e-63 206.1 23.8 4e-05 23.9 0.1 15.7 16 0 0 16 16 16 13 Ankyrin repeat Ank_3 PF13606.6 EMC84021.1 - 3.7e-62 198.9 17.7 0.00044 20.5 0.0 15.7 16 0 0 16 16 16 13 Ankyrin repeat Ank_5 PF13857.6 EMC84021.1 - 1.3e-61 203.9 20.9 1.1e-09 38.3 0.1 11.9 5 5 7 12 12 12 11 Ankyrin repeats (many copies) IQ PF00612.27 EMC84021.1 - 2.4e-07 30.0 9.1 0.0032 17.1 1.0 2.8 2 0 0 2 2 2 2 IQ calmodulin-binding motif DUF4192 PF13830.6 EMC84021.1 - 7.5 6.5 9.3 0.61 10.1 2.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4192) PAS PF00989.25 EMC84022.1 - 6.7e-11 42.2 0.0 1.3e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.12 EMC84022.1 - 8.7e-06 25.9 0.4 0.011 16.0 0.1 2.4 2 0 0 2 2 2 2 PAS fold HLH PF00010.26 EMC84022.1 - 1.4e-05 25.0 0.1 3.4e-05 23.7 0.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_11 PF14598.6 EMC84022.1 - 4.3e-05 23.6 0.3 0.0018 18.3 0.0 2.5 2 0 0 2 2 2 1 PAS domain PAS_9 PF13426.7 EMC84022.1 - 0.0018 18.5 0.0 0.014 15.7 0.0 2.3 2 0 0 2 2 2 1 PAS domain Herpes_U5 PF05999.11 EMC84022.1 - 0.037 12.8 0.1 0.059 12.1 0.1 1.2 1 0 0 1 1 1 0 Herpesvirus U5-like family PAS_4 PF08448.10 EMC84022.1 - 0.076 13.3 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 PAS fold EF-hand_7 PF13499.6 EMC84023.1 - 1.4e-24 86.3 1.3 3e-11 43.6 0.7 3.1 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EMC84023.1 - 5.6e-23 78.7 8.4 3.1e-07 29.5 0.1 5.3 5 1 0 5 5 5 5 EF hand EF-hand_6 PF13405.6 EMC84023.1 - 5.1e-21 72.8 5.6 4.3e-07 29.3 0.1 5.2 5 0 0 5 5 5 5 EF-hand domain EF-hand_8 PF13833.6 EMC84023.1 - 4e-20 71.4 3.4 1.8e-06 27.7 0.1 4.6 2 2 3 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.6 EMC84023.1 - 5.9e-13 47.7 2.8 0.00035 19.9 0.1 4.1 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 EMC84023.1 - 0.0057 16.9 0.0 0.6 10.5 0.0 2.9 3 0 0 3 3 3 1 EF-hand domain WWE PF02825.20 EMC84023.1 - 0.014 16.0 0.3 0.58 10.8 0.2 2.5 2 1 0 2 2 2 0 WWE domain EF-hand_2 PF09068.11 EMC84023.1 - 0.051 13.7 0.0 3 8.0 0.0 2.4 2 1 0 2 2 2 0 EF hand Sec6 PF06046.13 EMC84024.1 - 1.8e-158 528.5 15.3 1.8e-158 528.5 15.3 1.5 2 0 0 2 2 2 1 Exocyst complex component Sec6 Bcl-2 PF00452.19 EMC84024.1 - 0.015 16.0 0.0 0.093 13.4 0.0 2.5 1 0 0 1 1 1 0 Apoptosis regulator proteins, Bcl-2 family Tma16 PF11176.8 EMC84024.1 - 0.14 12.1 3.2 6.1 6.7 0.5 3.3 2 0 0 2 2 2 0 Translation machinery-associated protein 16 DHC_N1 PF08385.12 EMC84025.1 - 2.6e-162 541.4 25.3 2.6e-162 541.4 25.3 3.3 3 0 0 3 3 3 2 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 EMC84025.1 - 7.4e-149 495.1 0.1 1.2e-147 491.2 0.0 3.0 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EMC84025.1 - 4.3e-116 388.3 12.4 4.3e-116 388.3 12.4 5.1 6 1 0 6 6 6 1 Dynein heavy chain, N-terminal region 2 Dynein_C PF18199.1 EMC84025.1 - 2.5e-97 325.8 1.1 1.2e-96 323.6 0.0 2.8 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_8 PF12780.7 EMC84025.1 - 3.2e-94 315.1 0.0 1.3e-93 313.0 0.0 2.2 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 EMC84025.1 - 7.1e-85 283.6 1.9 7.1e-85 283.6 1.9 4.9 4 0 0 4 4 4 1 ATP-binding dynein motor region AAA_7 PF12775.7 EMC84025.1 - 4.1e-70 235.0 2.2 3.3e-65 219.0 0.2 3.9 3 0 0 3 3 3 2 P-loop containing dynein motor region AAA_lid_11 PF18198.1 EMC84025.1 - 9.2e-56 188.2 0.0 2.7e-55 186.7 0.0 1.9 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MT PF12777.7 EMC84025.1 - 1.3e-42 146.1 9.0 3.7e-42 144.6 9.0 1.8 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 EMC84025.1 - 8e-42 142.1 0.3 7.5e-41 139.0 0.0 2.9 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain AAA_lid_1 PF17857.1 EMC84025.1 - 7.8e-21 74.2 0.1 4.1e-20 71.9 0.1 2.4 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EMC84025.1 - 1.1e-20 74.0 0.0 2.9e-06 27.3 0.0 5.4 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 EMC84025.1 - 2.2e-19 69.8 0.3 2.3e-18 66.5 0.3 3.1 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA PF00004.29 EMC84025.1 - 1.2e-06 29.0 0.1 1.9 8.9 0.0 5.0 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EMC84025.1 - 0.0016 18.9 0.0 2.9 8.2 0.0 5.1 4 0 0 4 4 4 1 AAA ATPase domain AAA_22 PF13401.6 EMC84025.1 - 0.0048 17.2 2.8 3.9 7.7 0.0 5.0 5 0 0 5 5 5 1 AAA domain ImcF-related_N PF14331.6 EMC84025.1 - 0.068 12.5 0.1 0.19 11.0 0.1 1.7 1 0 0 1 1 1 0 ImcF-related N-terminal domain FerA PF08165.11 EMC84025.1 - 0.75 9.8 3.0 5.8 6.9 0.4 3.9 3 0 0 3 3 3 0 FerA (NUC095) domain HlyE PF06109.13 EMC84025.1 - 6.6 5.9 8.2 0.87 8.8 0.6 3.0 3 0 0 3 3 3 0 Haemolysin E (HlyE) PTRF_SDPR PF15237.6 EMC84026.1 - 5.7e-92 307.8 17.5 8e-92 307.3 17.5 1.1 1 0 0 1 1 1 1 PTRF/SDPR family DUF1664 PF07889.12 EMC84026.1 - 0.014 15.4 7.9 0.014 15.4 7.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) ZnuA PF01297.17 EMC84026.1 - 0.044 13.2 2.0 0.079 12.4 2.0 1.4 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic MCPsignal PF00015.21 EMC84026.1 - 1 9.2 15.5 0.23 11.3 2.9 2.9 2 2 1 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Hormone_1 PF00103.20 EMC84026.1 - 2.3 7.9 6.0 3.1 7.5 1.0 2.7 2 1 1 3 3 3 0 Somatotropin hormone family Kazal_2 PF07648.15 EMC84027.1 - 1.6e-20 72.9 24.1 4.5e-12 45.9 5.0 3.8 3 0 0 3 3 3 2 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EMC84027.1 - 1.3e-13 50.7 28.1 2.3e-07 30.7 10.4 3.7 2 2 1 3 3 3 2 Kazal-type serine protease inhibitor domain DUF3844 PF12955.7 EMC84027.1 - 0.0026 17.9 1.3 0.0026 17.9 1.3 3.6 2 1 1 3 3 3 1 Domain of unknown function (DUF3844) EphA2_TM PF14575.6 EMC84027.1 - 0.021 15.7 1.2 0.037 14.9 0.3 1.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain GRA6 PF05084.13 EMC84027.1 - 0.074 13.0 0.5 0.2 11.6 0.0 1.8 2 0 0 2 2 2 0 Granule antigen protein (GRA6) Mucin-like PF16058.5 EMC84028.1 - 1.2e-11 44.6 75.7 0.019 15.0 14.3 4.8 1 1 1 3 3 3 3 Mucin-like Mucin-like PF16058.5 EMC84029.1 - 1.8e-10 40.8 0.0 2.1 8.5 0.0 4.6 1 1 2 4 4 4 4 Mucin-like IQ PF00612.27 EMC84032.1 - 0.046 13.5 3.8 0.2 11.6 3.8 2.2 1 0 0 1 1 1 0 IQ calmodulin-binding motif HEAT_EZ PF13513.6 EMC84032.1 - 0.058 13.9 0.8 0.3 11.7 0.8 2.3 1 0 0 1 1 1 0 HEAT-like repeat IMD PF08397.11 EMC84034.1 - 1.1e-68 230.9 8.1 7.9e-65 218.3 5.2 2.1 2 0 0 2 2 2 2 IRSp53/MIM homology domain SH3_9 PF14604.6 EMC84034.1 - 3.1e-10 39.8 0.0 5.6e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC84034.1 - 1.2e-07 31.3 0.0 2e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC84034.1 - 3.7e-05 23.2 0.0 6.6e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 SH3 domain BAR PF03114.18 EMC84034.1 - 0.00032 20.4 5.8 0.00051 19.8 5.8 1.4 1 0 0 1 1 1 1 BAR domain BAR_3 PF16746.5 EMC84034.1 - 0.022 14.5 8.6 0.033 13.9 8.6 1.2 1 0 0 1 1 1 0 BAR domain of APPL family Peptidase_Mx1 PF15890.5 EMC84034.1 - 0.035 13.5 0.3 0.056 12.9 0.3 1.3 1 0 0 1 1 1 0 Putative zinc-binding metallo-peptidase DUF445 PF04286.12 EMC84034.1 - 0.096 12.5 0.9 0.14 12.0 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) RasGAP PF00616.19 EMC84034.1 - 0.21 11.2 7.9 0.12 12.0 5.7 1.6 2 0 0 2 2 2 0 GTPase-activator protein for Ras-like GTPase Exonuc_VII_L PF02601.15 EMC84034.1 - 0.37 10.3 1.8 0.51 9.9 1.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Snf7 PF03357.21 EMC84035.1 - 3.6e-20 72.3 4.4 3.6e-20 72.3 4.4 1.8 2 0 0 2 2 2 1 Snf7 Raptor_N PF14538.6 EMC84036.1 - 2.5e-58 196.2 0.2 1.1e-57 194.1 0.2 2.1 1 1 0 1 1 1 1 Raptor N-terminal CASPase like domain HEAT PF02985.22 EMC84036.1 - 5.7e-14 51.0 2.7 0.00053 20.0 0.0 5.9 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.6 EMC84036.1 - 4e-10 39.9 0.0 4.7e-06 26.9 0.0 3.8 3 1 1 4 4 4 2 HEAT repeats WD40 PF00400.32 EMC84036.1 - 7.6e-09 36.1 8.2 0.081 13.8 0.2 7.3 7 0 0 7 7 7 2 WD domain, G-beta repeat Cnd1 PF12717.7 EMC84036.1 - 3.1e-07 30.6 0.0 0.00031 20.8 0.0 3.5 2 1 2 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EMC84036.1 - 3.5e-05 24.2 0.2 1.3 9.6 0.0 3.9 3 0 0 3 3 3 2 HEAT-like repeat ANAPC4_WD40 PF12894.7 EMC84036.1 - 0.027 14.8 0.0 15 5.9 0.0 3.2 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Hyccin PF09790.9 EMC84036.1 - 0.035 13.2 0.1 0.057 12.5 0.1 1.3 1 0 0 1 1 1 0 Hyccin Pentaxin PF00354.17 EMC84037.1 - 6.3e-34 117.4 0.0 8.2e-34 117.0 0.0 1.0 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.6 EMC84037.1 - 1.7e-16 60.7 0.0 2.3e-16 60.3 0.0 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 EMC84037.1 - 0.011 16.2 0.0 0.015 15.8 0.0 1.2 1 0 0 1 1 1 0 Laminin G domain DUF3024 PF11225.8 EMC84037.1 - 0.03 14.6 0.0 0.054 13.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3024) Endonuclease_5 PF04493.14 EMC84039.1 - 4.1e-65 219.2 0.0 4.7e-65 219.0 0.0 1.0 1 0 0 1 1 1 1 Endonuclease V Sulfatase PF00884.23 EMC84040.1 - 7.7e-49 166.8 0.0 3e-48 164.8 0.0 1.9 1 1 0 1 1 1 1 Sulfatase DUF4976 PF16347.5 EMC84040.1 - 5.8e-09 36.1 0.4 3.6e-07 30.4 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4976) Phosphodiest PF01663.22 EMC84040.1 - 7.2e-08 32.4 0.0 7.5e-06 25.8 0.0 2.3 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase_C PF14707.6 EMC84040.1 - 0.0028 18.4 0.2 0.0057 17.4 0.2 1.5 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase DUF2264 PF10022.9 EMC84040.1 - 0.036 13.2 0.0 0.057 12.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2264) BRE1 PF08647.11 EMC84041.1 - 3.3e-13 49.5 17.1 3.3e-13 49.5 17.1 12.0 6 3 3 11 11 11 1 BRE1 E3 ubiquitin ligase Vac_Fusion PF02346.16 EMC84041.1 - 0.019 14.6 1.7 3.2 7.4 0.4 4.2 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 NTS PF15447.6 EMC84041.1 - 0.29 11.7 3.7 0.85 10.2 0.0 3.3 3 0 0 3 3 3 0 N-terminal segments of PfEMP1 RabGAP-TBC PF00566.18 EMC84042.1 - 2e-36 125.7 6.1 5.1e-36 124.4 6.1 1.6 1 1 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 EMC84042.1 - 3.1e-06 26.8 0.0 0.021 14.3 0.0 2.3 2 0 0 2 2 2 2 Rab-binding domain (RBD) CBX7_C PF17218.3 EMC84043.1 - 4.6e-13 48.6 0.8 1.1e-12 47.4 0.8 1.7 1 0 0 1 1 1 1 CBX family C-terminal motif UPF0561 PF10573.9 EMC84043.1 - 1.8 8.7 7.4 0.8 9.8 0.3 2.7 3 0 0 3 3 3 0 Uncharacterised protein family UPF0561 CBX7_C PF17218.3 EMC84044.1 - 2e-13 49.8 1.9 3e-13 49.2 1.9 1.3 1 0 0 1 1 1 1 CBX family C-terminal motif Phosphodiest PF01663.22 EMC84045.1 - 1.8e-46 159.4 0.3 2.2e-46 159.1 0.3 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 EMC84045.1 - 4.6e-09 36.0 0.0 6.7e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 EMC84045.1 - 0.00073 19.0 0.1 0.0018 17.8 0.0 1.8 2 0 0 2 2 2 1 Sulfatase PglZ PF08665.12 EMC84045.1 - 0.026 14.6 0.0 0.039 14.1 0.0 1.2 1 0 0 1 1 1 0 PglZ domain Fox-1_C PF12414.8 EMC84046.1 - 3.5e-44 149.1 15.3 7.9e-44 148.0 15.3 1.6 1 0 0 1 1 1 1 Calcitonin gene-related peptide regulator C terminal RRM_1 PF00076.22 EMC84046.1 - 8e-19 67.2 1.5 1.1e-18 66.8 0.1 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMC84046.1 - 0.033 13.8 0.0 0.049 13.2 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) C1q PF00386.21 EMC84047.1 - 4.3e-39 133.6 1.8 5.2e-39 133.3 1.8 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 EMC84047.1 - 2.1e-08 33.8 13.0 3.1e-08 33.2 13.0 1.2 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) Apyrase PF06079.11 EMC84048.1 - 3.1e-75 253.1 0.2 3.7e-75 252.9 0.2 1.0 1 0 0 1 1 1 1 Apyrase TIMP PF00965.17 EMC84049.1 - 1e-31 110.2 8.0 1.1e-31 110.0 8.0 1.0 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase UCH PF00443.29 EMC84050.1 - 4.2e-52 177.2 0.0 4.9e-52 177.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMC84050.1 - 1.3e-22 80.8 0.6 2.4e-22 80.0 0.6 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF2913 PF11140.8 EMC84050.1 - 0.035 13.9 0.0 0.055 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2913) Peptidase_C98 PF15499.6 EMC84050.1 - 0.95 8.9 4.1 4.9 6.5 0.1 2.8 2 1 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase DZR PF12773.7 EMC84050.1 - 7.1 6.7 8.4 5.6 7.1 1.9 2.9 2 1 0 2 2 2 0 Double zinc ribbon Sec7 PF01369.20 EMC84052.1 - 1.9e-75 252.5 0.1 2.6e-75 252.1 0.1 1.2 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 EMC84052.1 - 1.1e-29 103.0 0.1 2e-29 102.1 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EMC84052.1 - 1.8e-06 28.3 0.1 4.2e-06 27.1 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 EMC84052.1 - 0.0032 17.5 0.1 0.021 14.9 0.1 2.2 1 1 0 1 1 1 1 PH domain PH_8 PF15409.6 EMC84052.1 - 0.0093 16.2 0.0 0.086 13.1 0.0 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain Pilosulin PF17499.2 EMC84052.1 - 0.019 15.1 0.0 0.054 13.7 0.0 1.7 1 0 0 1 1 1 0 Ant venom peptides GPS2_interact PF15784.5 EMC84052.1 - 0.023 15.1 2.1 0.049 14.1 2.1 1.5 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain PH_16 PF17838.1 EMC84052.1 - 0.03 14.2 0.0 0.24 11.2 0.1 2.2 2 0 0 2 2 2 0 PH domain BBS2_C PF14782.6 EMC84052.1 - 0.032 13.0 1.9 1.4 7.6 1.1 2.1 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, C-terminal APG6_N PF17675.1 EMC84052.1 - 0.047 14.2 2.4 0.09 13.3 2.4 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region FlgN PF05130.12 EMC84052.1 - 0.062 13.8 1.5 0.13 12.8 1.5 1.5 1 0 0 1 1 1 0 FlgN protein NUDE_C PF04880.13 EMC84052.1 - 0.65 10.5 4.0 1.1 9.7 4.0 1.3 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region PLDc_2 PF13091.6 EMC84053.1 - 5.8e-14 52.1 0.0 1.3e-05 25.1 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EMC84053.1 - 0.079 13.2 2.3 2.2 8.6 0.2 2.7 2 1 0 2 2 2 0 Phospholipase D Active site motif SH2 PF00017.24 EMC84054.1 - 1.7e-10 40.8 0.0 3.5e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.16 EMC84054.1 - 1.4e-05 25.3 0.0 2.9e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 SOCS box Exostosin PF03016.15 EMC84054.1 - 0.0074 15.5 0.0 0.0095 15.2 0.0 1.1 1 0 0 1 1 1 1 Exostosin family Abhydrolase_3 PF07859.13 EMC84055.1 - 2.2e-06 27.7 0.6 1.8e-05 24.7 0.6 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMC84055.1 - 0.0013 18.0 0.1 0.0061 15.9 0.1 1.8 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EMC84055.1 - 0.0015 19.2 0.6 0.002 18.8 0.6 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.13 EMC84055.1 - 0.0039 16.9 0.0 0.0049 16.5 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) LIDHydrolase PF10230.9 EMC84055.1 - 0.018 14.6 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Peptidase_S9 PF00326.21 EMC84055.1 - 0.021 14.3 0.0 0.034 13.6 0.0 1.3 1 1 0 1 1 1 0 Prolyl oligopeptidase family DUF2974 PF11187.8 EMC84055.1 - 0.2 11.2 0.0 0.26 10.8 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2974) MARVEL PF01284.23 EMC84056.1 - 8.5e-18 64.8 15.9 1.1e-17 64.4 15.9 1.1 1 0 0 1 1 1 1 Membrane-associating domain Arf PF00025.21 EMC84057.1 - 5.7e-09 35.7 0.0 6.7e-09 35.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Hrs_helical PF12210.8 EMC84058.1 - 1e-38 131.8 3.4 1e-38 131.8 3.4 2.8 3 0 0 3 3 3 1 Hepatocyte growth factor-regulated tyrosine kinase substrate VHS PF00790.19 EMC84058.1 - 1.2e-32 112.6 1.6 3.4e-32 111.2 1.6 1.8 1 0 0 1 1 1 1 VHS domain FYVE PF01363.21 EMC84058.1 - 8.2e-18 64.3 10.0 2e-17 63.1 10.0 1.6 1 0 0 1 1 1 1 FYVE zinc finger UIM PF02809.20 EMC84058.1 - 0.023 14.6 6.7 0.069 13.1 6.7 1.9 1 0 0 1 1 1 0 Ubiquitin interaction motif DUF4575 PF15143.6 EMC84058.1 - 2 8.6 15.3 0.26 11.5 0.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4575) Mito_carr PF00153.27 EMC84059.1 - 1.7e-34 117.6 4.2 1.5e-13 50.5 0.1 4.6 4 1 0 4 4 4 4 Mitochondrial carrier protein 7tm_2 PF00002.24 EMC84061.1 - 1.6e-81 273.3 20.9 2.4e-81 272.7 20.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 EMC84061.1 - 1.7e-14 53.9 3.6 1.7e-14 53.9 3.6 1.7 2 0 0 2 2 2 1 Hormone receptor domain TMEM43 PF07787.12 EMC84061.1 - 4.1 6.7 6.8 0.34 10.3 1.8 1.6 2 0 0 2 2 2 0 Transmembrane protein 43 Ank_4 PF13637.6 EMC84062.1 - 2.9e-11 43.7 0.1 5e-11 42.9 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC84062.1 - 2e-10 40.7 0.0 3e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC84062.1 - 2.8e-09 37.5 0.1 2e-08 34.7 0.1 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EMC84062.1 - 6.7e-09 35.8 2.4 5.7e-05 23.4 0.1 2.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EMC84062.1 - 9.6e-08 31.7 0.2 0.00072 19.8 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeat Thioredoxin_6 PF13848.6 EMC84063.1 - 1.6e-46 158.6 1.2 2.7e-44 151.3 1.5 2.9 2 1 1 3 3 3 1 Thioredoxin-like domain Thioredoxin PF00085.20 EMC84063.1 - 6.5e-31 106.4 0.1 2.2e-29 101.5 0.0 2.9 3 0 0 3 3 3 1 Thioredoxin ERp29_N PF07912.13 EMC84063.1 - 5e-06 26.7 0.4 1.4 9.1 0.0 3.3 3 0 0 3 3 3 2 ERp29, N-terminal domain Thioredoxin_2 PF13098.6 EMC84063.1 - 0.00036 20.9 0.0 0.0011 19.4 0.0 1.9 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EMC84063.1 - 0.00042 20.6 0.0 0.013 15.8 0.0 2.7 2 0 0 2 2 2 1 Thioredoxin-like OST3_OST6 PF04756.13 EMC84063.1 - 0.00089 18.7 0.1 0.21 10.9 0.0 2.7 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 EMC84063.1 - 0.00094 19.3 0.0 0.019 15.1 0.0 2.6 2 0 0 2 2 2 1 Thioredoxin-like Redoxin PF08534.10 EMC84063.1 - 0.0016 18.2 0.1 0.3 10.8 0.0 2.4 2 0 0 2 2 2 2 Redoxin HNF-1A_C PF04813.12 EMC84064.1 - 0.0023 18.7 16.8 1.2 10.0 2.5 3.2 1 1 2 3 3 3 3 Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus Rho_GDI PF02115.17 EMC84065.1 - 5.8e-63 212.2 0.4 1.5e-41 142.3 0.0 2.0 1 1 1 2 2 2 2 RHO protein GDP dissociation inhibitor DUF4249 PF14054.6 EMC84065.1 - 0.042 13.5 0.0 0.046 13.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4249) FoP_duplication PF13865.6 EMC84066.1 - 2e-10 41.0 14.6 4.4e-10 40.0 14.6 1.7 1 1 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 RRM_1 PF00076.22 EMC84066.1 - 3.2e-09 36.5 0.0 4.7e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-ANAPC11 PF12861.7 EMC84067.1 - 1e-25 89.6 14.6 1.1e-25 89.5 14.6 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EMC84067.1 - 1.1e-17 64.1 16.7 1.2e-17 64.0 16.7 1.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EMC84067.1 - 8.6e-06 26.0 21.1 2.3e-05 24.6 21.1 1.7 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EMC84067.1 - 0.013 15.3 12.3 0.013 15.3 12.3 2.1 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC84067.1 - 0.44 10.4 22.9 2.8 7.9 23.1 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 EMC84067.1 - 2 8.3 10.2 2.6 7.9 10.2 1.4 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Opy2 PF09463.10 EMC84067.1 - 2.5 8.5 15.3 0.74 10.2 8.6 2.1 2 0 0 2 2 2 0 Opy2 protein zf-RING_5 PF14634.6 EMC84067.1 - 7.7 6.6 20.8 63 3.7 21.1 2.1 1 1 1 2 2 2 0 zinc-RING finger domain YSIRK_signal PF04650.17 EMC84068.1 - 2.5e-16 59.2 52.5 1.6e+02 2.3 0.0 26.6 29 0 0 29 29 29 28 YSIRK type signal peptide CTP_transf_like PF01467.26 EMC84069.1 - 4.5e-41 140.4 0.0 2.2e-26 92.7 0.0 2.1 2 0 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 EMC84069.1 - 0.0036 17.2 1.5 0.12 12.3 0.0 2.9 3 0 0 3 3 3 1 FAD synthetase CHAP PF05257.16 EMC84069.1 - 0.024 15.2 0.0 0.074 13.6 0.0 1.7 1 1 0 1 1 1 0 CHAP domain SIR2 PF02146.17 EMC84070.1 - 1.8e-28 99.7 1.9 8.4e-22 77.9 0.7 2.0 1 1 1 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.22 EMC84070.1 - 0.077 12.7 0.0 0.43 10.3 0.0 2.0 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain bZIP_Maf PF03131.17 EMC84071.1 - 1.3e-33 115.4 11.7 1.6e-33 115.1 11.7 1.1 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.21 EMC84071.1 - 3.5e-05 23.8 15.7 0.00035 20.6 15.7 2.3 1 1 0 1 1 1 1 bZIP transcription factor DivIC PF04977.15 EMC84071.1 - 9.9e-05 22.0 5.8 9.9e-05 22.0 5.8 2.2 1 1 1 2 2 2 1 Septum formation initiator DUF1192 PF06698.11 EMC84071.1 - 0.00056 19.9 5.7 0.024 14.7 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1192) Prominin PF05478.11 EMC84071.1 - 0.00056 18.0 1.8 0.0007 17.7 1.8 1.0 1 0 0 1 1 1 1 Prominin DUF4164 PF13747.6 EMC84071.1 - 0.0017 18.6 2.7 0.0017 18.6 2.7 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4164) DUF2353 PF09789.9 EMC84071.1 - 0.003 17.0 5.9 0.0036 16.7 5.9 1.1 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) Cnn_1N PF07989.11 EMC84071.1 - 0.0061 16.7 8.7 0.014 15.6 8.7 1.7 1 1 0 1 1 1 1 Centrosomin N-terminal motif 1 JIP_LZII PF16471.5 EMC84071.1 - 0.0071 16.5 2.6 0.0071 16.5 2.6 2.2 2 1 0 2 2 2 1 JNK-interacting protein leucine zipper II ThrE_2 PF12821.7 EMC84071.1 - 0.012 15.7 0.1 0.017 15.3 0.1 1.1 1 0 0 1 1 1 0 Threonine/Serine exporter, ThrE FapA PF03961.13 EMC84071.1 - 0.015 13.9 4.6 0.02 13.5 4.6 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A HAUS-augmin3 PF14932.6 EMC84071.1 - 0.02 14.5 6.7 0.025 14.2 6.7 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Atg14 PF10186.9 EMC84071.1 - 0.023 13.8 2.0 0.024 13.7 2.0 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 YabA PF06156.13 EMC84071.1 - 0.055 14.1 3.6 0.055 14.1 3.6 2.1 1 1 1 2 2 2 0 Initiation control protein YabA bZIP_2 PF07716.15 EMC84071.1 - 0.074 13.1 16.8 0.11 12.5 13.4 2.7 1 1 1 2 2 2 0 Basic region leucine zipper Mod_r PF07200.13 EMC84071.1 - 0.083 13.0 7.6 0.11 12.6 7.2 1.3 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Tox-ODYAM1 PF15642.6 EMC84071.1 - 0.091 11.7 3.1 0.12 11.4 3.1 1.1 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus DUF3584 PF12128.8 EMC84071.1 - 0.19 9.2 8.1 0.22 9.0 8.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) GIT_CC PF16559.5 EMC84071.1 - 0.28 11.1 6.0 0.24 11.3 4.1 2.0 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DASH_Spc19 PF08287.11 EMC84071.1 - 0.45 10.4 10.9 0.64 9.9 10.9 1.2 1 0 0 1 1 1 0 Spc19 DUF4407 PF14362.6 EMC84071.1 - 0.51 9.7 5.0 0.71 9.2 4.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 EMC84071.1 - 0.74 8.6 11.3 2.2 7.1 11.3 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein BST2 PF16716.5 EMC84071.1 - 0.86 10.2 9.6 1.7 9.3 9.2 1.6 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 Mst1_SARAH PF11629.8 EMC84071.1 - 1 9.5 9.6 4.9 7.3 2.9 2.7 2 1 0 2 2 2 0 C terminal SARAH domain of Mst1 Nup54 PF13874.6 EMC84071.1 - 1.1 9.4 8.9 1.5 8.9 8.9 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 ZapB PF06005.12 EMC84071.1 - 1.3 9.5 16.4 1.3 9.5 8.8 2.6 1 1 1 2 2 2 0 Cell division protein ZapB Spc24 PF08286.11 EMC84071.1 - 2 8.7 9.1 0.61 10.4 5.3 1.9 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF2205 PF10224.9 EMC84071.1 - 2.1 8.4 9.8 0.73 9.9 4.9 2.1 1 1 1 2 2 2 0 Short coiled-coil protein APG6_N PF17675.1 EMC84071.1 - 2.3 8.7 15.2 8.6 6.9 15.2 1.8 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF4140 PF13600.6 EMC84071.1 - 8 7.0 8.1 48 4.5 8.1 2.1 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) HALZ PF02183.18 EMC84071.1 - 8.8 6.6 13.4 11 6.3 4.2 2.9 2 1 1 3 3 3 0 Homeobox associated leucine zipper P5CR_dimer PF14748.6 EMC84072.1 - 2e-37 127.6 0.0 3.4e-37 126.8 0.0 1.4 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EMC84072.1 - 1.4e-08 35.2 0.0 2.5e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 EMC84072.1 - 0.021 14.5 0.0 0.035 13.8 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.23 EMC84072.1 - 0.13 12.2 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UBX PF00789.20 EMC84073.1 - 1.2e-12 47.9 0.0 2.6e-08 33.9 0.0 2.5 2 0 0 2 2 2 2 UBX domain TUG-UBL1 PF11470.8 EMC84073.1 - 3.7e-06 27.0 0.1 7.2e-06 26.1 0.1 1.5 1 0 0 1 1 1 1 TUG ubiquitin-like domain DUF4164 PF13747.6 EMC84073.1 - 0.21 11.9 0.9 0.43 10.9 0.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) LRR_6 PF13516.6 EMC84075.1 - 7.4e-17 59.9 14.0 0.00019 21.2 0.1 5.6 5 0 0 5 5 5 4 Leucine Rich repeat LRR_1 PF00560.33 EMC84075.1 - 8.3e-06 25.7 4.4 2.5 9.0 1.2 5.8 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_8 PF13855.6 EMC84075.1 - 0.00068 19.3 15.8 0.068 12.9 3.6 3.9 2 1 0 2 2 2 2 Leucine rich repeat MCR_D PF02505.14 EMC84075.1 - 0.036 13.9 1.0 3.8 7.3 0.0 2.6 2 0 0 2 2 2 0 Methyl-coenzyme M reductase operon protein D LRR_4 PF12799.7 EMC84075.1 - 0.037 14.5 13.6 0.82 10.2 3.7 3.8 2 1 2 4 4 4 0 Leucine Rich repeats (2 copies) RPN7 PF10602.9 EMC84076.1 - 2e-61 206.7 0.3 4.2e-61 205.6 0.3 1.6 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EMC84076.1 - 1.3e-17 64.3 1.2 6.3e-17 62.0 0.2 2.3 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.17 EMC84076.1 - 0.004 17.2 4.5 0.15 12.2 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMC84076.1 - 0.031 14.0 1.0 0.11 12.2 0.0 2.4 2 0 0 2 2 2 0 TPR repeat TPR_1 PF00515.28 EMC84076.1 - 0.079 12.8 5.2 0.18 11.7 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TRIC PF05197.13 EMC84079.1 - 1.2e-82 276.1 4.8 1.4e-82 275.9 4.8 1.1 1 0 0 1 1 1 1 TRIC channel UPF0126 PF03458.13 EMC84079.1 - 0.023 14.6 6.3 0.49 10.3 0.1 2.7 2 1 0 2 2 2 0 UPF0126 domain HLH PF00010.26 EMC84080.1 - 2.3e-17 62.7 0.8 3.1e-17 62.3 0.8 1.2 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PMBR PF09373.10 EMC84080.1 - 0.013 15.7 0.2 0.22 11.7 0.0 2.2 2 0 0 2 2 2 0 Pseudomurein-binding repeat COE1_HLH PF16423.5 EMC84080.1 - 0.02 14.6 0.0 0.034 13.9 0.0 1.3 1 0 0 1 1 1 0 Transcription factor COE1 helix-loop-helix domain RF-1 PF00472.20 EMC84080.1 - 0.097 12.6 0.1 0.13 12.2 0.1 1.2 1 0 0 1 1 1 0 RF-1 domain zf-C3HC4_2 PF13923.6 EMC84081.1 - 7.1e-14 51.4 9.4 1.3e-13 50.5 9.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC84081.1 - 5.1e-11 42.3 8.7 8.9e-11 41.5 8.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC84081.1 - 1.1e-10 41.6 10.0 2.5e-10 40.5 10.0 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EMC84081.1 - 6.1e-10 38.8 8.3 1e-09 38.1 8.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC84081.1 - 7.2e-07 29.1 6.3 1.4e-06 28.2 6.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC84081.1 - 1.2e-05 25.1 10.3 0.00056 19.7 11.1 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EMC84081.1 - 1.3e-05 25.1 9.0 2.8e-05 24.1 9.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 EMC84081.1 - 3.5e-05 24.0 10.5 9.4e-05 22.6 10.5 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EMC84081.1 - 0.0026 17.9 11.3 0.0051 16.9 11.3 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 EMC84081.1 - 0.015 15.1 5.2 0.042 13.6 5.2 1.8 1 0 0 1 1 1 0 RING-like zinc finger Baculo_IE-1 PF05290.11 EMC84081.1 - 0.015 15.2 3.5 0.025 14.5 3.5 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-ANAPC11 PF12861.7 EMC84081.1 - 0.02 14.9 5.0 0.052 13.6 5.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Rad50_zn_hook PF04423.14 EMC84081.1 - 0.089 12.6 0.5 5.6 6.9 0.1 2.5 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-RING_6 PF14835.6 EMC84081.1 - 0.22 11.4 2.2 0.5 10.3 2.2 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 EMC84081.1 - 0.6 10.0 10.2 3.5 7.5 10.2 2.0 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain LicD PF04991.13 EMC84082.1 - 3.8e-06 27.2 0.4 2e-05 24.8 0.1 2.4 2 1 1 3 3 3 1 LicD family SPRY PF00622.28 EMC84083.1 - 6.4e-14 52.1 0.2 1.3e-13 51.2 0.2 1.5 1 0 0 1 1 1 1 SPRY domain fn3 PF00041.21 EMC84083.1 - 4e-05 23.9 0.0 0.00016 21.9 0.0 2.0 2 0 0 2 2 2 1 Fibronectin type III domain Helo_like_N PF17111.5 EMC84083.1 - 0.0049 16.3 0.7 0.0095 15.3 0.7 1.4 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins Hrs_helical PF12210.8 EMC84083.1 - 0.013 16.0 1.5 0.028 15.0 1.5 1.5 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Bac_thur_toxin PF01338.18 EMC84083.1 - 0.048 13.1 1.4 0.059 12.8 0.0 1.8 2 0 0 2 2 2 0 Bacillus thuringiensis toxin GAS PF13851.6 EMC84083.1 - 0.062 12.6 3.6 0.13 11.6 3.6 1.5 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding NPV_P10 PF05531.12 EMC84083.1 - 0.18 12.3 3.5 3.4 8.2 0.1 2.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein UPF0061 PF02696.14 EMC84083.1 - 0.57 8.9 2.7 0.81 8.4 2.7 1.2 1 0 0 1 1 1 0 Uncharacterized ACR, YdiU/UPF0061 family FlaC_arch PF05377.11 EMC84083.1 - 1.6 9.1 3.9 3.2 8.2 0.3 2.8 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Choline_transpo PF04515.12 EMC84085.1 - 8.3e-103 344.0 36.7 8.3e-103 344.0 36.7 2.7 2 1 1 3 3 3 1 Plasma-membrane choline transporter DUF4307 PF14155.6 EMC84085.1 - 0.47 10.3 1.6 1.7 8.5 0.5 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4307) DUF4131 PF13567.6 EMC84085.1 - 2.3 7.9 0.0 2.3 7.9 0.0 4.8 3 1 1 4 4 4 0 Domain of unknown function (DUF4131) ABC2_membrane_3 PF12698.7 EMC84086.1 - 8.8e-59 199.3 53.2 2e-46 158.7 24.5 3.8 3 1 0 3 3 3 2 ABC-2 family transporter protein ABC_tran PF00005.27 EMC84086.1 - 2.8e-52 176.9 0.0 1.4e-28 100.2 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EMC84086.1 - 1e-18 68.2 0.0 2.4e-06 27.6 0.0 4.4 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.6 EMC84086.1 - 3.7e-05 24.4 0.1 0.061 14.1 0.0 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF4162) AAA_29 PF13555.6 EMC84086.1 - 0.012 15.3 1.2 0.51 10.1 0.3 3.0 3 0 0 3 3 3 0 P-loop containing region of AAA domain AAA_23 PF13476.6 EMC84086.1 - 0.013 16.0 5.2 0.047 14.2 0.7 2.5 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EMC84086.1 - 0.18 11.7 0.2 7.6 6.4 0.1 2.4 2 0 0 2 2 2 0 RsgA GTPase AAA_15 PF13175.6 EMC84086.1 - 0.29 10.8 3.0 2.1 8.0 0.0 3.7 5 0 0 5 5 5 0 AAA ATPase domain NIPSNAP PF07978.13 EMC84087.1 - 7.1e-50 167.5 0.6 1.2e-29 102.5 0.3 2.0 2 0 0 2 2 2 2 NIPSNAP Esterase PF00756.20 EMC84087.1 - 0.023 14.3 0.4 3.3 7.3 0.1 2.2 2 0 0 2 2 2 0 Putative esterase Lipase PF00151.19 EMC84088.1 - 7.5e-121 403.5 0.0 9.3e-121 403.2 0.0 1.1 1 0 0 1 1 1 1 Lipase PLAT PF01477.23 EMC84088.1 - 8.6e-21 74.7 0.8 1.7e-20 73.7 0.8 1.5 1 0 0 1 1 1 1 PLAT/LH2 domain Abhydrolase_6 PF12697.7 EMC84088.1 - 0.00047 20.8 0.2 0.00068 20.3 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EMC84088.1 - 0.001 18.8 0.0 0.002 17.8 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Neuregulin PF02158.15 EMC84089.1 - 3.8e-151 503.5 35.6 6.6e-151 502.8 35.6 1.4 1 0 0 1 1 1 1 Neuregulin intracellular region EGF PF00008.27 EMC84089.1 - 0.0017 18.6 3.8 0.0043 17.3 3.8 1.7 1 0 0 1 1 1 1 EGF-like domain Saf_2TM PF18303.1 EMC84089.1 - 0.07 12.7 0.2 0.75 9.4 0.0 2.2 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain DUF973 PF06157.11 EMC84089.1 - 0.11 11.6 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF973) Cyt_b-c1_8 PF10890.8 EMC84089.1 - 0.12 12.8 0.0 0.24 11.8 0.0 1.5 1 0 0 1 1 1 0 Cytochrome b-c1 complex subunit 8 TMEM132D_C PF15706.5 EMC84089.1 - 0.14 11.9 0.0 0.35 10.7 0.0 1.6 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term EGF_2 PF07974.13 EMC84089.1 - 0.61 10.5 2.8 2.7 8.4 2.8 2.2 1 1 0 1 1 1 0 EGF-like domain Miga PF10265.9 EMC84089.1 - 6.1 5.7 6.4 2.4 7.0 2.3 1.9 2 0 0 2 2 2 0 Mitoguardin PPTA PF01239.22 EMC84090.1 - 9.3e-50 165.0 16.6 4.7e-12 45.2 0.5 5.9 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat TPR_14 PF13428.6 EMC84090.1 - 0.12 13.2 1.3 15 6.7 0.4 3.8 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF4219 PF13961.6 EMC84090.1 - 1.7 8.4 12.4 20 5.0 0.1 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4219) zf-Di19 PF05605.12 EMC84091.1 - 3.6e-22 78.4 1.5 3.6e-22 78.4 1.5 1.9 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding ZZ PF00569.17 EMC84091.1 - 1.1e-09 37.9 6.2 1.1e-09 37.9 6.2 2.5 3 0 0 3 3 3 1 Zinc finger, ZZ type TagA PF12561.8 EMC84091.1 - 0.002 18.5 0.0 0.0027 18.1 0.0 1.4 1 0 0 1 1 1 1 ToxR activated gene A lipoprotein domain zf-C2H2 PF00096.26 EMC84091.1 - 0.0096 16.3 0.3 0.0096 16.3 0.3 3.2 3 1 0 3 3 1 1 Zinc finger, C2H2 type Di19_C PF14571.6 EMC84091.1 - 0.038 14.5 3.3 0.038 14.5 3.3 2.2 1 1 1 2 2 2 0 Stress-induced protein Di19, C-terminal TFIIA PF03153.13 EMC84091.1 - 0.077 13.0 7.3 0.095 12.7 7.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Dicty_REP PF05086.12 EMC84091.1 - 0.087 10.8 3.7 0.11 10.4 3.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein zinc_ribbon_9 PF14369.6 EMC84091.1 - 0.1 12.8 1.6 12 6.3 0.1 2.9 2 0 0 2 2 2 0 zinc-ribbon zf-C2H2_jaz PF12171.8 EMC84091.1 - 0.33 11.3 0.1 0.33 11.3 0.1 2.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 EMC84091.1 - 0.52 11.0 4.7 29 5.4 0.3 3.4 3 0 0 3 3 3 0 FOXP coiled-coil domain DUF4407 PF14362.6 EMC84091.1 - 0.54 9.6 5.3 0.71 9.2 5.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-ribbon_3 PF13248.6 EMC84091.1 - 2.5 7.6 8.8 3.4 7.2 0.3 2.9 3 0 0 3 3 3 0 zinc-ribbon domain HOOK PF05622.12 EMC84092.1 - 1.2e-50 172.4 6.8 1.4e-50 172.3 6.8 1.0 1 0 0 1 1 1 1 HOOK protein TEX13 PF15186.6 EMC84092.1 - 0.0047 16.6 1.0 0.0073 16.0 1.0 1.4 1 0 0 1 1 1 1 Testis-expressed sequence 13 protein family Mod_r PF07200.13 EMC84092.1 - 0.021 14.9 5.2 0.026 14.7 5.2 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein CCDC-167 PF15188.6 EMC84092.1 - 0.038 14.3 3.3 0.064 13.6 3.3 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 SMAP PF15477.6 EMC84092.1 - 0.048 14.6 2.3 0.048 14.6 2.3 2.0 2 0 0 2 2 2 0 Small acidic protein family FlxA PF14282.6 EMC84092.1 - 0.061 13.3 2.5 0.084 12.9 2.5 1.5 1 1 0 1 1 1 0 FlxA-like protein DNA_pol_alpha_N PF12254.8 EMC84092.1 - 0.11 12.6 1.4 0.11 12.6 0.1 1.8 2 0 0 2 2 2 0 DNA polymerase alpha subunit p180 N terminal Tho2 PF11262.8 EMC84092.1 - 0.14 11.3 5.0 0.17 11.1 5.0 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 TMPIT PF07851.13 EMC84092.1 - 0.32 10.2 2.7 0.35 10.1 2.7 1.1 1 0 0 1 1 1 0 TMPIT-like protein FapA PF03961.13 EMC84092.1 - 0.45 9.0 3.1 0.47 9.0 3.1 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Bap31_Bap29_C PF18035.1 EMC84092.1 - 1.1 9.3 8.6 0.7 9.9 6.3 1.9 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain DALR_2 PF09190.11 EMC84093.1 - 0.0001 22.7 0.0 0.0027 18.1 0.0 2.7 2 0 0 2 2 2 1 DALR domain Carb_kinase PF01256.17 EMC84094.1 - 1.1e-55 188.8 0.0 1.4e-55 188.5 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.15 EMC84094.1 - 0.045 13.1 0.0 0.064 12.6 0.0 1.3 1 0 0 1 1 1 0 Hydroxyethylthiazole kinase family Suc_Fer-like PF06999.12 EMC84094.1 - 0.048 13.5 0.0 0.062 13.2 0.0 1.3 1 0 0 1 1 1 0 Sucrase/ferredoxin-like Ras PF00071.22 EMC84095.1 - 8.5e-30 103.5 0.0 2.5e-29 101.9 0.0 1.6 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EMC84095.1 - 2.1e-21 76.4 0.0 3.3e-21 75.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC84095.1 - 8.5e-12 44.9 0.0 1.1e-11 44.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC84095.1 - 1.4e-05 25.1 0.0 2.9e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EMC84095.1 - 0.037 13.5 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EMC84095.1 - 0.23 11.4 0.2 12 5.7 0.1 2.2 2 0 0 2 2 2 0 RsgA GTPase C4 PF01413.19 EMC84096.1 - 2.9e-84 278.8 2.2 1.1e-45 154.6 0.1 2.0 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen Integrase_H2C2 PF17921.1 EMC84096.1 - 0.077 13.1 1.2 9 6.5 0.1 2.4 2 0 0 2 2 2 0 Integrase zinc binding domain Collagen PF01391.18 EMC84097.1 - 2.8e-30 103.8 95.9 6.5e-11 41.8 18.2 4.1 2 1 2 4 4 4 4 Collagen triple helix repeat (20 copies) Collagen PF01391.18 EMC84098.1 - 5.7e-204 660.2 759.4 6.3e-10 38.7 25.2 27.2 5 4 20 25 25 25 24 Collagen triple helix repeat (20 copies) C4 PF01413.19 EMC84098.1 - 3.4e-78 259.2 5.7 4.9e-44 149.3 0.3 2.1 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen NT-C2 PF10358.9 EMC84099.1 - 0.1 12.3 0.5 8 6.2 0.0 2.9 3 2 0 3 3 3 0 N-terminal C2 in EEIG1 and EHBP1 proteins PH PF00169.29 EMC84099.1 - 1.6 9.3 4.4 14 6.3 0.6 2.6 1 1 1 2 2 2 0 PH domain SMN PF06003.12 EMC84099.1 - 2.8 7.1 19.4 4.6 6.4 5.8 2.1 1 1 1 2 2 2 0 Survival motor neuron protein (SMN) Actin PF00022.19 EMC84100.1 - 3.1e-86 289.6 0.0 2.2e-52 178.1 0.0 2.0 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 EMC84100.1 - 3.3e-05 22.9 0.0 0.052 12.4 0.0 2.3 2 1 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 EMC84100.1 - 0.018 15.4 0.0 0.043 14.2 0.0 1.8 2 1 0 2 2 2 0 Cell division protein FtsA Robl_LC7 PF03259.17 EMC84100.1 - 0.073 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Roadblock/LC7 domain EamA PF00892.20 EMC84101.1 - 5.4e-11 42.8 41.2 3.5e-06 27.2 5.9 3.2 3 0 0 3 3 3 3 EamA-like transporter family BAGE PF08180.11 EMC84101.1 - 0.18 11.9 0.0 0.35 11.0 0.0 1.5 1 0 0 1 1 1 0 B melanoma antigen family MHYT PF03707.16 EMC84101.1 - 0.82 9.9 6.1 0.97 9.6 0.0 3.3 3 1 0 3 3 3 0 Bacterial signalling protein N terminal repeat 7tm_1 PF00001.21 EMC84102.1 - 2.2e-35 122.3 6.8 2.2e-35 122.3 6.8 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 EMC84102.1 - 2.8e-05 23.6 10.9 0.00016 21.2 1.2 2.5 2 1 1 3 3 3 2 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 EMC84102.1 - 0.00046 20.0 3.1 0.025 14.3 1.3 2.5 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC84102.1 - 0.0025 17.5 3.9 0.0025 17.5 3.9 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DDA1 PF10172.9 EMC84102.1 - 4.8 7.5 5.7 13 6.1 0.4 3.3 3 0 0 3 3 3 0 Det1 complexing ubiquitin ligase UPAR_LY6_2 PF16975.5 EMC84103.1 - 0.0009 19.4 9.2 0.0012 19.0 9.2 1.1 1 0 0 1 1 1 1 Ly6/PLAUR domain-containing protein 6, Lypd6 NCKAP5 PF15246.6 EMC84104.1 - 1.1e-32 114.0 0.8 1.4e-32 113.6 0.8 1.2 1 0 0 1 1 1 1 Nck-associated protein 5, Peripheral clock protein NCKAP5 PF15246.6 EMC84105.1 - 1.4e-79 267.9 17.8 1.4e-79 267.9 17.8 5.1 6 1 1 7 7 7 1 Nck-associated protein 5, Peripheral clock protein Sigma70_ner PF04546.13 EMC84105.1 - 0.24 11.2 10.5 0.73 9.7 10.5 1.8 1 0 0 1 1 1 0 Sigma-70, non-essential region TSC22 PF01166.18 EMC84105.1 - 7.8 6.9 7.6 33 4.9 0.1 3.7 2 0 0 2 2 2 0 TSC-22/dip/bun family Glyco_transf_18 PF15024.6 EMC84106.1 - 1.4e-264 878.9 0.8 1.8e-264 878.6 0.8 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 18 DUF4525 PF15027.6 EMC84106.1 - 1.1e-64 216.3 0.1 1.8e-64 215.5 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4525) Cation_efflux PF01545.21 EMC84107.1 - 0.0045 16.8 28.9 0.96 9.1 29.1 3.5 1 1 1 2 2 2 1 Cation efflux family DUF308 PF03729.13 EMC84107.1 - 3.2 8.2 21.2 4 7.8 8.1 3.3 2 1 1 3 3 3 0 Short repeat of unknown function (DUF308) DUF2157 PF09925.9 EMC84107.1 - 4.1 7.2 9.8 1.1 9.0 5.0 2.3 1 1 1 2 2 2 0 Predicted membrane protein (DUF2157) Amidohydro_2 PF04909.14 EMC84108.1 - 3.6e-64 217.3 0.0 4e-64 217.2 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase Pkinase PF00069.25 EMC84109.1 - 6.4e-56 189.6 0.0 7.2e-56 189.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC84109.1 - 2.5e-38 131.8 0.0 3e-38 131.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC84109.1 - 1.7e-07 30.8 0.0 2.4e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMC84109.1 - 0.00012 21.0 0.0 0.00015 20.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMC84109.1 - 0.00098 19.1 0.1 0.0027 17.7 0.1 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EMC84109.1 - 0.13 11.2 0.0 0.19 10.7 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Haspin_kinase PF12330.8 EMC84109.1 - 0.24 10.3 0.0 0.33 9.8 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Rab3-GTPase_cat PF13890.6 EMC84110.1 - 3.1e-68 228.5 0.0 1.7e-67 226.1 0.0 2.2 3 0 0 3 3 3 1 Rab3 GTPase-activating protein catalytic subunit UBX PF00789.20 EMC84111.1 - 5.7e-19 68.1 0.0 1.1e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 UBX domain Hamartin PF04388.12 EMC84111.1 - 0.37 9.4 17.4 0.56 8.8 17.4 1.2 1 0 0 1 1 1 0 Hamartin protein Glyco_hydro_1 PF00232.18 EMC84112.1 - 0 1796.3 16.0 1.1e-175 584.5 1.3 4.2 4 0 0 4 4 4 4 Glycosyl hydrolase family 1 tRNA-synt_2 PF00152.20 EMC84113.1 - 1.2e-77 261.1 0.1 1.5e-77 260.7 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EMC84113.1 - 2.9e-10 40.0 1.0 5.2e-10 39.2 1.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EMC84113.1 - 0.00012 21.6 0.4 0.57 9.6 0.2 2.5 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) S-AdoMet_synt_N PF00438.20 EMC84113.1 - 0.0077 16.9 0.2 0.056 14.1 0.2 2.2 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain tRNA_anti_2 PF13742.6 EMC84113.1 - 0.023 14.9 0.2 0.059 13.6 0.2 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain 7tm_1 PF00001.21 EMC84114.1 - 6e-51 173.3 14.4 7.4e-51 173.0 14.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CXCR4_N PF12109.8 EMC84114.1 - 2.3e-19 69.3 5.6 4e-19 68.5 5.6 1.4 1 0 0 1 1 1 1 CXCR4 Chemokine receptor N terminal 7TM_GPCR_Srsx PF10320.9 EMC84114.1 - 0.0028 17.1 14.6 0.0042 16.5 14.6 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TctB PF07331.11 EMC84114.1 - 0.41 10.9 10.9 0.19 12.0 2.5 2.5 1 1 1 2 2 2 0 Tripartite tricarboxylate transporter TctB family COX2_TM PF02790.15 EMC84114.1 - 0.47 10.6 0.1 0.47 10.6 0.1 2.7 3 1 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain TSP_1 PF00090.19 EMC84115.1 - 1.7e-42 143.4 224.0 5.8e-09 36.0 8.6 23.1 23 4 0 23 23 23 14 Thrombospondin type 1 domain AfaD PF05775.12 EMC84115.1 - 0.074 13.5 0.0 0.2 12.1 0.0 1.7 1 0 0 1 1 1 0 Enterobacteria AfaD invasin protein Methyltransf_23 PF13489.6 EMC84116.1 - 1.2e-13 51.3 0.0 1.6e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC84116.1 - 0.00028 21.6 0.0 0.00045 20.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC84116.1 - 0.0003 20.6 0.0 0.00062 19.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain PSY3 PF16836.5 EMC84116.1 - 0.013 15.0 0.2 0.024 14.2 0.2 1.4 1 0 0 1 1 1 0 Shu complex component Psy3, DNA-binding description Methyltransf_23 PF13489.6 EMC84117.1 - 2.4e-19 69.8 0.0 3.6e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC84117.1 - 9.1e-09 36.0 0.0 1.7e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC84117.1 - 4.5e-05 23.3 0.0 7.1e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DUF5099 PF17025.5 EMC84117.1 - 0.056 13.9 0.1 0.19 12.1 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5099) Glutaredoxin PF00462.24 EMC84117.1 - 0.098 12.9 0.0 0.35 11.1 0.0 1.9 1 0 0 1 1 1 0 Glutaredoxin Methyltransf_11 PF08241.12 EMC84117.1 - 0.18 12.5 0.0 0.37 11.5 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain BTB PF00651.31 EMC84118.1 - 7.3e-35 119.6 0.7 4.2e-34 117.1 0.1 2.1 1 1 1 2 2 2 1 BTB/POZ domain MATH PF00917.26 EMC84118.1 - 1.5e-06 28.4 0.0 2.8e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 MATH domain Neurexophilin PF06312.12 EMC84119.1 - 1.2e-97 325.5 4.2 1.5e-97 325.2 4.2 1.0 1 0 0 1 1 1 1 Neurexophilin VWD PF00094.25 EMC84120.1 - 2.8e-12 47.2 0.2 4e-11 43.4 0.0 2.7 3 0 0 3 3 3 1 von Willebrand factor type D domain EGF PF00008.27 EMC84120.1 - 1.6e-09 37.9 178.7 4e-05 23.8 7.5 13.0 12 0 0 12 12 12 7 EGF-like domain EGF_2 PF07974.13 EMC84120.1 - 1.4e-08 35.0 181.0 0.0014 18.9 7.0 12.9 10 2 2 12 12 12 9 EGF-like domain hEGF PF12661.7 EMC84120.1 - 0.00043 20.8 153.1 0.0035 17.9 4.6 13.3 12 0 0 12 12 12 8 Human growth factor-like EGF Ldl_recept_a PF00057.18 EMC84121.1 - 6.5e-289 931.8 617.0 2.6e-12 46.8 16.7 36.0 35 0 0 35 35 35 32 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 EMC84121.1 - 3.7e-177 574.6 83.2 8.6e-10 38.9 0.0 36.5 38 1 0 38 38 38 28 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 EMC84121.1 - 1.3e-61 204.6 344.6 4.1e-11 43.0 6.8 25.4 19 1 5 24 24 24 15 Coagulation Factor Xa inhibitory site DUF5050 PF16472.5 EMC84121.1 - 2.5e-32 112.3 9.2 6.8e-09 35.4 0.0 7.0 7 0 0 7 7 7 6 Domain of unknown function (DUF5050) SGL PF08450.12 EMC84121.1 - 2.6e-21 76.3 30.6 0.00068 19.3 0.2 14.8 10 5 5 15 15 15 5 SMP-30/Gluconolactonase/LRE-like region cEGF PF12662.7 EMC84121.1 - 1.9e-18 66.0 129.8 1.5e-09 37.6 0.8 17.3 16 0 0 16 16 16 8 Complement Clr-like EGF-like EGF_3 PF12947.7 EMC84121.1 - 0.00085 19.5 6.0 0.00085 19.5 6.0 28.7 30 1 0 30 30 30 7 EGF domain TMEM154 PF15102.6 EMC84121.1 - 0.15 11.9 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family Aminotran_5 PF00266.19 EMC84122.1 - 4.5e-08 32.4 0.0 7.2e-08 31.8 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class-V RhoGAP PF00620.27 EMC84123.1 - 1.5e-53 180.7 1.0 8e-53 178.3 0.0 2.3 2 1 0 2 2 2 1 RhoGAP domain RPEL PF02755.15 EMC84123.1 - 0.00047 19.8 0.4 0.0014 18.2 0.4 1.9 1 0 0 1 1 1 1 RPEL repeat DUF5617 PF18493.1 EMC84123.1 - 0.075 13.1 0.0 0.25 11.5 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5617) Y_phosphatase PF00102.27 EMC84125.1 - 2.3e-126 420.1 6.7 2.6e-83 279.2 0.7 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 EMC84125.1 - 0.00049 19.9 0.1 0.003 17.4 0.0 2.3 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC84125.1 - 0.00094 19.2 0.1 0.0022 18.0 0.0 1.6 2 0 0 2 2 2 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EMC84125.1 - 0.068 13.3 0.0 0.3 11.2 0.0 2.1 2 0 0 2 2 2 0 Inositol hexakisphosphate FHA PF00498.26 EMC84126.1 - 6.1e-13 48.9 0.0 8.6e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EMC84126.1 - 2.6e-09 37.3 0.0 3.3e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain FHA_2 PF17913.1 EMC84126.1 - 0.00083 19.6 0.0 0.00093 19.4 0.0 1.1 1 0 0 1 1 1 1 FHA domain PP1_bind PF15276.6 EMC84127.1 - 4.3e-24 84.6 2.2 5.4e-24 84.3 2.2 1.2 1 0 0 1 1 1 1 Protein phosphatase 1 binding KI67R PF08065.12 EMC84128.1 - 8.4e-24 84.3 16.9 1.9e-10 41.3 1.9 4.4 3 1 2 5 5 5 3 KI67R (NUC007) repeat PI_PP_C PF18365.1 EMC84128.1 - 0.021 14.8 0.6 6.1 6.8 0.1 3.1 1 1 0 2 2 2 0 Phosphoinositide phosphatase C-terminal domain DUF1298 PF06974.13 EMC84128.1 - 0.076 13.0 0.6 5.3 7.0 0.1 2.8 1 1 3 4 4 4 0 Protein of unknown function (DUF1298) HTH_49 PF18010.1 EMC84128.1 - 0.096 12.6 0.1 1.9e+02 2.1 0.0 4.2 4 0 0 4 4 4 0 Cry35Ab1 HTH C-terminal domain DUF2122 PF09895.9 EMC84128.1 - 0.11 12.9 0.1 3.7 8.0 0.0 2.5 2 0 0 2 2 2 0 RecB-family nuclease (DUF2122) Na_Ca_ex_C PF16494.5 EMC84128.1 - 0.67 10.4 4.4 13 6.3 1.6 2.7 1 1 1 2 2 2 0 C-terminal extension of sodium/calcium exchanger domain CHS5_N PF16892.5 EMC84129.1 - 6.3e-06 26.0 2.8 5.6 7.0 0.0 5.5 1 1 5 6 6 6 1 Chitin biosynthesis protein CHS5 N-terminus AFP PF02420.15 EMC84129.1 - 0.00056 19.9 11.6 34 5.2 0.0 6.0 6 0 0 6 6 6 0 Insect antifreeze protein repeat Romo1 PF10247.9 EMC84129.1 - 0.0085 16.4 22.2 3.3 8.1 0.6 5.1 1 1 4 5 5 5 4 Reactive mitochondrial oxygen species modulator 1 Pox_EPC_I2-L1 PF12575.8 EMC84129.1 - 0.012 15.9 8.9 33 4.8 0.0 4.6 4 1 1 5 5 5 0 Poxvirus entry protein complex L1 and I2 FANCAA PF15146.6 EMC84129.1 - 0.059 12.4 0.3 2.6 7.0 0.0 2.0 1 1 1 2 2 2 0 Fanconi anemia-associated Paired_CXXCH_1 PF09699.10 EMC84129.1 - 0.063 13.0 0.4 1.1e+02 2.6 0.0 4.5 5 1 0 5 5 5 0 Doubled CXXCH motif (Paired_CXXCH_1) IFR3_antag PF14754.6 EMC84129.1 - 0.1 11.8 5.2 1.4 8.1 1.6 2.1 1 1 1 2 2 2 0 Papain-like auto-proteinase DUF1270 PF06900.11 EMC84129.1 - 3.1 8.2 12.6 98 3.4 0.1 4.8 1 1 4 5 5 5 0 Protein of unknown function (DUF1270) BAMBI PF06211.12 EMC84132.1 - 0.091 13.0 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain Pacs-1 PF10254.9 EMC84133.1 - 5.7e-190 631.6 0.3 9e-190 631.0 0.0 1.5 2 0 0 2 2 2 1 PACS-1 cytosolic sorting protein hNIFK_binding PF12196.8 EMC84133.1 - 0.21 11.1 1.2 0.59 9.7 1.2 1.8 1 0 0 1 1 1 0 FHA Ki67 binding domain of hNIFK Cul7 PF11515.8 EMC84134.1 - 1.9e-35 121.0 0.3 3.5e-35 120.1 0.3 1.4 1 0 0 1 1 1 1 Mouse development and cellular proliferation protein Cullin-7 DUF1918 PF08940.11 EMC84134.1 - 0.043 13.4 0.3 8.7 6.1 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1918) Ribosomal_L2_C PF03947.18 EMC84135.1 - 5.3e-30 104.2 0.4 1.5e-29 102.7 0.2 1.8 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EMC84135.1 - 1.5e-21 76.1 1.2 2e-21 75.7 0.1 1.8 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain TPR_12 PF13424.6 EMC84136.1 - 2.4e-53 178.3 14.0 3.6e-20 72.0 0.8 4.7 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 EMC84136.1 - 1.2e-50 168.1 18.6 8.1e-11 41.4 0.1 7.4 7 1 1 8 8 7 6 Tetratricopeptide repeat TPR_1 PF00515.28 EMC84136.1 - 1.1e-25 88.4 28.6 1.6e-07 30.8 0.5 6.8 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_7 PF13176.6 EMC84136.1 - 1.1e-25 87.7 14.1 1e-05 25.2 0.0 7.2 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 EMC84136.1 - 3.4e-18 64.2 24.6 0.00079 19.3 0.4 6.6 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 EMC84136.1 - 1.4e-14 53.0 21.8 0.0017 18.4 0.1 6.8 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_MalT PF17874.1 EMC84136.1 - 8.2e-13 48.4 7.4 1.1e-11 44.7 0.8 3.3 3 1 0 3 3 3 1 MalT-like TPR region TPR_16 PF13432.6 EMC84136.1 - 2.1e-12 47.4 2.3 0.0019 18.8 1.3 5.1 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 EMC84136.1 - 1.1e-11 45.0 7.4 0.0002 21.8 0.1 4.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 EMC84136.1 - 7.5e-09 35.7 4.6 6.4 7.9 0.2 6.6 3 1 3 6 6 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC84136.1 - 4.9e-08 33.1 13.0 0.0049 17.1 0.1 4.0 2 1 2 4 4 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EMC84136.1 - 9.1e-08 32.0 14.4 0.082 13.3 0.1 6.4 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_4 PF07721.14 EMC84136.1 - 2.6e-06 27.5 2.3 2.2 9.2 0.2 6.5 8 0 0 8 8 6 1 Tetratricopeptide repeat PPR PF01535.20 EMC84136.1 - 0.00027 21.0 2.7 0.11 12.8 0.0 4.5 6 0 0 6 6 3 1 PPR repeat Uso1_p115_C PF04871.13 EMC84136.1 - 0.0029 18.0 10.5 0.0029 18.0 10.5 2.4 2 0 0 2 2 2 1 Uso1 / p115 like vesicle tethering protein, C terminal region JIP_LZII PF16471.5 EMC84136.1 - 0.0034 17.5 5.3 0.0034 17.5 5.3 2.5 2 1 0 2 2 2 1 JNK-interacting protein leucine zipper II TMF_TATA_bd PF12325.8 EMC84136.1 - 0.0045 17.2 8.0 0.0045 17.2 8.0 2.3 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding DUF627 PF04781.12 EMC84136.1 - 0.013 15.5 3.9 0.41 10.7 0.1 3.6 2 2 1 3 3 3 0 Protein of unknown function (DUF627) PPR_2 PF13041.6 EMC84136.1 - 0.032 14.4 0.8 4 7.7 0.0 3.3 3 0 0 3 3 3 0 PPR repeat family SHNi-TPR PF10516.9 EMC84136.1 - 0.049 13.1 2.7 6.3 6.3 0.1 4.0 4 0 0 4 4 4 0 SHNi-TPR GHL5 PF14872.6 EMC84136.1 - 0.07 11.2 2.1 0.1 10.6 2.1 1.2 1 0 0 1 1 1 0 Hypothetical glycoside hydrolase 5 Csm1_N PF18504.1 EMC84136.1 - 0.13 12.6 8.3 0.63 10.4 8.0 2.5 1 1 0 1 1 1 0 Csm1 N-terminal domain WbqC PF08889.11 EMC84136.1 - 0.14 12.0 2.8 4 7.3 0.0 3.3 3 1 1 4 4 3 0 WbqC-like protein family COG2 PF06148.11 EMC84136.1 - 0.4 10.8 8.3 0.47 10.5 6.8 2.0 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 TPR_11 PF13414.6 EMC84136.1 - 0.65 9.7 13.9 1.1 9.1 0.2 5.5 5 0 0 5 5 5 0 TPR repeat DUF3450 PF11932.8 EMC84136.1 - 0.68 9.2 9.8 1.5 8.1 9.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) RasGAP_C PF03836.15 EMC84136.1 - 0.95 9.6 10.7 1.5 8.9 9.4 2.1 1 1 0 1 1 1 0 RasGAP C-terminus Spc7 PF08317.11 EMC84136.1 - 1.2 8.0 18.4 2 7.2 18.4 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein SOGA PF11365.8 EMC84136.1 - 2.6 9.2 16.1 6.8 7.9 7.8 3.8 1 1 1 3 3 3 0 Protein SOGA FapA PF03961.13 EMC84136.1 - 3.2 6.3 8.1 5.4 5.5 8.1 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF3972 PF13118.6 EMC84136.1 - 3.6 8.0 11.4 1.7e+02 2.6 11.4 2.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3972) TPR_3 PF07720.12 EMC84136.1 - 6.5 6.9 14.4 5 7.2 0.7 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat YabA PF06156.13 EMC84136.1 - 8.2 7.1 17.2 0.21 12.3 5.5 3.6 3 0 0 3 3 2 0 Initiation control protein YabA SOUL PF04832.12 EMC84137.1 - 1.9e-36 125.8 0.2 2.2e-36 125.6 0.2 1.1 1 0 0 1 1 1 1 SOUL heme-binding protein I-set PF07679.16 EMC84139.1 - 2.4e-88 290.3 0.0 3.2e-14 52.8 0.0 7.3 7 0 0 7 7 7 7 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC84139.1 - 1.2e-86 285.4 8.2 1.9e-13 50.8 0.2 7.3 7 0 0 7 7 7 7 Immunoglobulin domain Pkinase_Tyr PF07714.17 EMC84139.1 - 2.4e-83 279.4 0.0 3.4e-83 278.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_2 PF13895.6 EMC84139.1 - 9.3e-66 218.2 9.5 4.7e-11 42.9 0.1 7.3 7 0 0 7 7 7 7 Immunoglobulin domain ig PF00047.25 EMC84139.1 - 4.6e-50 167.7 4.2 2e-07 31.1 0.0 7.5 7 0 0 7 7 7 7 Immunoglobulin domain Pkinase PF00069.25 EMC84139.1 - 4.3e-41 141.0 0.0 6.5e-41 140.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain V-set PF07686.17 EMC84139.1 - 1.9e-27 95.6 8.3 0.01 16.0 0.1 10.4 7 3 2 9 9 9 6 Immunoglobulin V-set domain Ig_6 PF18452.1 EMC84139.1 - 3e-20 71.5 0.5 0.01 15.4 0.0 7.2 7 0 0 7 7 7 5 Immunoglobulin domain Ig_5 PF16681.5 EMC84139.1 - 1.9e-17 63.4 0.1 0.025 15.0 0.0 7.0 7 1 0 7 7 7 4 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 EMC84139.1 - 2.1e-12 47.0 9.6 0.71 10.0 0.1 7.0 7 0 0 7 7 7 5 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.5 EMC84139.1 - 2e-11 44.0 1.5 0.51 10.6 0.0 7.2 7 1 0 7 7 7 3 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 EMC84139.1 - 8.4e-09 35.4 0.0 0.23 11.5 0.0 6.2 6 0 0 6 6 6 2 Izumo-like Immunoglobulin domain C1-set PF07654.15 EMC84139.1 - 1.6e-06 28.4 0.6 2.2 8.7 0.0 5.6 5 0 0 5 5 5 1 Immunoglobulin C1-set domain C2-set PF05790.15 EMC84139.1 - 7.3e-06 26.1 0.4 2.7 8.3 0.0 6.1 6 0 0 6 6 6 1 Immunoglobulin C2-set domain V-set_CD47 PF08204.11 EMC84139.1 - 2.7e-05 24.2 0.4 0.43 10.6 0.0 4.1 4 0 0 4 4 4 2 CD47 immunoglobulin-like domain Adeno_E3_CR1 PF02440.15 EMC84139.1 - 0.0013 18.5 1.5 7.9 6.3 0.0 5.0 5 1 0 5 5 5 1 Adenovirus E3 region protein CR1 CD34_antigen PF06365.12 EMC84139.1 - 0.045 13.3 0.1 0.18 11.4 0.0 1.8 2 0 0 2 2 2 0 CD34/Podocalyxin family Ig_C17orf99 PF17736.1 EMC84139.1 - 0.3 11.2 7.5 10 6.2 0.0 5.1 5 1 0 5 5 5 0 C17orf99 Ig domain Cul7 PF11515.8 EMC84141.1 - 4.5e-31 107.0 0.2 8.1e-31 106.1 0.2 1.4 1 0 0 1 1 1 1 Mouse development and cellular proliferation protein Cullin-7 HR1 PF02185.16 EMC84141.1 - 0.11 12.6 0.0 0.39 10.9 0.0 1.9 1 0 0 1 1 1 0 Hr1 repeat UPF0020 PF01170.18 EMC84142.1 - 1.3e-27 96.7 0.0 6.3e-27 94.5 0.0 1.9 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.6 EMC84142.1 - 1.4e-14 54.5 0.0 3e-14 53.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC84142.1 - 1.8e-13 50.5 0.0 4.3e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC84142.1 - 1.2e-11 45.1 0.0 4.8e-11 43.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain THUMP PF02926.17 EMC84142.1 - 4.8e-09 36.5 0.0 9.9e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 THUMP domain Ubie_methyltran PF01209.18 EMC84142.1 - 3.7e-08 33.0 0.0 5.8e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EMC84142.1 - 1.4e-07 31.2 0.0 2.2e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain AviRa PF11599.8 EMC84142.1 - 0.011 15.2 0.7 0.073 12.5 0.0 2.4 2 1 1 3 3 3 0 RRNA methyltransferase AviRa Methyltransf_12 PF08242.12 EMC84142.1 - 0.011 16.4 0.0 0.029 15.1 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 EMC84142.1 - 0.037 13.3 0.0 0.051 12.9 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Cons_hypoth95 PF03602.15 EMC84142.1 - 0.043 13.5 0.0 0.095 12.3 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical protein 95 N6_Mtase PF02384.16 EMC84142.1 - 0.1 11.9 0.0 0.26 10.5 0.0 1.6 1 1 0 1 1 1 0 N-6 DNA Methylase Methyltransf_15 PF09445.10 EMC84142.1 - 0.2 11.2 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase MARVEL PF01284.23 EMC84143.1 - 4.5e-06 26.8 6.4 4.5e-06 26.8 6.4 2.2 2 0 0 2 2 2 2 Membrane-associating domain DUF485 PF04341.12 EMC84143.1 - 1.5 8.8 9.3 1.4 8.9 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF485 Ribosomal_S5_C PF03719.15 EMC84144.1 - 1.1e-23 82.4 0.2 2e-23 81.6 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 EMC84144.1 - 1.3e-16 60.3 3.1 3.5e-16 58.9 3.1 1.8 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain YbfN PF13982.6 EMC84144.1 - 0.062 13.6 0.1 0.19 12.1 0.1 1.7 1 0 0 1 1 1 0 YbfN-like lipoprotein Sld5 PF05916.11 EMC84145.1 - 2.1e-05 25.0 0.2 0.00014 22.3 0.1 2.2 3 0 0 3 3 3 1 GINS complex protein CarD_CdnL_TRCF PF02559.16 EMC84146.1 - 0.21 12.3 2.2 0.72 10.6 2.2 2.0 1 1 0 1 1 1 0 CarD-like/TRCF domain CCDC144C PF14915.6 EMC84146.1 - 0.32 10.1 32.8 0.39 9.8 32.8 1.0 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region THP2 PF09432.10 EMC84146.1 - 0.74 9.9 7.4 0.26 11.4 3.8 1.9 1 1 1 2 2 2 0 Tho complex subunit THP2 Exonuc_VII_L PF02601.15 EMC84146.1 - 0.76 9.3 20.9 1 8.9 20.9 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Dna2 PF08696.11 EMC84146.1 - 2.3 8.0 8.2 3.6 7.4 8.0 1.6 1 1 0 1 1 1 0 DNA replication factor Dna2 MAD PF05557.13 EMC84146.1 - 2.4 6.4 31.4 3 6.1 31.4 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein DUF2730 PF10805.8 EMC84146.1 - 4.7 7.4 11.0 0.19 11.8 2.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) BSD PF03909.17 EMC84146.1 - 4.9 7.2 6.3 15 5.7 0.2 3.2 3 1 0 3 3 3 0 BSD domain OmpH PF03938.14 EMC84146.1 - 8.3 6.7 36.1 12 6.3 17.0 2.2 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DEAD PF00270.29 EMC84147.1 - 5.9e-36 123.9 0.0 9.4e-36 123.2 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC84147.1 - 2.9e-32 111.3 0.0 1.6e-31 108.9 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 EMC84147.1 - 0.0014 18.9 0.0 0.019 15.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 EMC84147.1 - 0.0016 18.5 0.0 0.0035 17.4 0.0 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EMC84147.1 - 0.023 15.0 0.0 0.28 11.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain Flavi_DEAD PF07652.14 EMC84147.1 - 0.092 12.7 0.2 0.36 10.8 0.1 2.2 1 1 1 2 2 2 0 Flavivirus DEAD domain ERCC3_RAD25_C PF16203.5 EMC84147.1 - 0.1 11.8 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Fanconi_A PF03511.14 EMC84147.1 - 0.16 11.9 0.3 1.4 8.9 0.0 2.4 3 0 0 3 3 3 0 Fanconi anaemia group A protein GBP PF02263.19 EMC84148.1 - 7.3e-103 343.4 0.1 9.7e-103 342.9 0.1 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.14 EMC84148.1 - 1.9e-06 27.6 0.1 3.9e-06 26.5 0.1 1.5 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain Tiam_CC_Ex PF18385.1 EMC84148.1 - 0.0051 17.2 0.0 0.021 15.2 0.0 2.0 1 0 0 1 1 1 1 T-lymphoma invasion and metastasis CC-Ex domain ATP-synt_A PF00119.20 EMC84148.1 - 0.033 14.1 0.1 0.066 13.1 0.1 1.5 1 0 0 1 1 1 0 ATP synthase A chain CD225 PF04505.12 EMC84149.1 - 1e-18 67.2 0.1 1.6e-18 66.6 0.1 1.3 1 0 0 1 1 1 1 Interferon-induced transmembrane protein MoeA_C PF03454.15 EMC84149.1 - 0.024 14.8 0.0 0.042 14.0 0.0 1.4 1 0 0 1 1 1 0 MoeA C-terminal region (domain IV) Cystatin PF00031.21 EMC84150.1 - 1.7e-26 92.3 0.0 2e-26 92.1 0.0 1.1 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.5 EMC84150.1 - 7.3e-05 23.0 0.0 0.00011 22.4 0.0 1.3 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor Cofilin_ADF PF00241.20 EMC84151.1 - 2.1e-32 111.5 0.2 2.6e-32 111.1 0.2 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Rib_recp_KP_reg PF05104.12 EMC84152.1 - 2.4e-32 113.1 44.1 2.4e-32 113.1 44.1 6.0 5 3 1 6 6 6 1 Ribosome receptor lysine/proline rich region ABC_export PF16962.5 EMC84152.1 - 0.044 12.2 0.2 0.068 11.6 0.2 1.2 1 0 0 1 1 1 0 Putative ABC exporter MLANA PF14991.6 EMC84152.1 - 3.2 8.0 5.4 12 6.3 0.1 4.2 3 0 0 3 3 3 0 Protein melan-A DUF3899 PF13038.6 EMC84152.1 - 3.9 8.0 4.6 2.1 8.9 0.5 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) PX PF00787.24 EMC84153.1 - 1.7e-19 69.9 0.3 1.7e-19 69.9 0.3 2.8 3 1 0 3 3 3 1 PX domain Vps5 PF09325.10 EMC84153.1 - 1.1e-16 61.1 18.4 1.8e-15 57.1 13.6 2.5 2 1 0 2 2 2 1 Vps5 C terminal like Glyco_hydro_97 PF10566.9 EMC84153.1 - 0.11 11.7 0.2 0.18 11.1 0.2 1.4 1 0 0 1 1 1 0 Glycoside hydrolase 97 LcrG PF07216.12 EMC84153.1 - 0.13 12.2 0.3 8.1 6.4 0.0 3.0 3 0 0 3 3 3 0 LcrG protein NusB PF01029.18 EMC84153.1 - 0.29 11.4 4.1 0.46 10.7 2.0 2.2 2 0 0 2 2 2 0 NusB family PDDEXK_1 PF12705.7 EMC84154.1 - 1.2e-07 31.9 0.0 8.1e-07 29.2 0.0 2.0 1 1 0 1 1 1 1 PD-(D/E)XK nuclease superfamily zf-C2H2 PF00096.26 EMC84155.1 - 3.9e-18 64.8 26.4 3.3e-05 24.1 2.4 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC84155.1 - 4e-17 61.8 24.1 5.1e-09 36.1 0.5 5.4 5 1 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC84155.1 - 5.2e-12 45.5 25.2 0.00039 21.0 1.7 4.5 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 EMC84155.1 - 4.5e-08 33.8 14.0 1.8e-06 28.6 0.7 3.0 2 1 1 3 3 3 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_jaz PF12171.8 EMC84155.1 - 5e-06 26.6 9.8 0.39 11.1 0.3 3.7 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC84155.1 - 5.6e-05 23.4 15.6 0.00088 19.6 2.2 4.4 3 1 1 4 4 4 1 Zinc-finger of C2H2 type zf_C2H2_ZHX PF18387.1 EMC84155.1 - 0.0001 21.8 0.0 0.0001 21.8 0.0 2.7 2 1 1 3 3 3 1 Zinc-fingers and homeoboxes C2H2 finger domain zf-H2C2_5 PF13909.6 EMC84155.1 - 0.00082 19.1 19.8 0.14 11.9 0.2 5.2 4 2 1 5 5 5 2 C2H2-type zinc-finger domain FYVE PF01363.21 EMC84155.1 - 0.0086 16.2 19.4 0.2 11.8 10.0 2.6 1 1 1 2 2 2 2 FYVE zinc finger zf-C2H2_6 PF13912.6 EMC84155.1 - 0.023 14.7 20.1 0.99 9.5 2.9 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_12 PF18658.1 EMC84155.1 - 0.045 13.3 0.0 0.045 13.3 0.0 3.1 1 1 3 4 4 4 0 Zinc-finger C2H2-type zf-C2H2_11 PF16622.5 EMC84155.1 - 0.56 10.0 20.4 0.15 11.9 1.3 3.9 4 0 0 4 4 4 0 zinc-finger C2H2-type DUF2256 PF10013.9 EMC84155.1 - 0.72 10.0 6.5 20 5.4 0.3 3.4 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) A2L_zn_ribbon PF08792.10 EMC84155.1 - 0.78 9.5 0.1 0.78 9.5 0.1 3.6 4 0 0 4 4 4 0 A2L zinc ribbon domain zf-MYST PF17772.1 EMC84155.1 - 0.8 9.4 12.9 5.3 6.7 0.1 4.1 4 0 0 4 4 4 0 MYST family zinc finger domain Zn-ribbon_8 PF09723.10 EMC84155.1 - 1 9.6 17.4 7.4 6.8 0.4 4.4 3 1 1 4 4 4 0 Zinc ribbon domain zinc_ribbon_15 PF17032.5 EMC84155.1 - 1 10.1 11.6 0.82 10.5 1.4 2.4 1 1 0 2 2 2 0 zinc-ribbon family zf_UBZ PF18439.1 EMC84155.1 - 1.1 8.9 11.6 3.2 7.4 0.7 4.1 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger XPA_N PF01286.18 EMC84155.1 - 1.2 9.2 9.4 47 4.1 0.1 4.2 4 0 0 4 4 4 0 XPA protein N-terminal zf-C2H2_2 PF12756.7 EMC84155.1 - 1.3 9.4 16.2 2.2 8.7 0.4 3.7 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) Rpr2 PF04032.16 EMC84155.1 - 1.9 8.8 16.1 1.4e+02 2.8 11.4 3.5 3 1 0 3 3 3 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain C5HCH PF17982.1 EMC84155.1 - 2.2 8.5 11.0 12 6.2 0.1 3.5 3 0 0 3 3 3 0 NSD Cys-His rich domain ADK_lid PF05191.14 EMC84155.1 - 5.8 7.0 10.8 0.71 9.9 1.3 3.4 3 1 0 3 3 3 0 Adenylate kinase, active site lid Acetyltransf_1 PF00583.25 EMC84156.1 - 5.7e-10 39.5 0.0 1.1e-09 38.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMC84156.1 - 1.9e-09 37.5 0.0 4.2e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMC84156.1 - 9.8e-08 32.3 0.0 1.9e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMC84156.1 - 7.6e-05 22.6 0.0 0.00014 21.7 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EMC84156.1 - 0.0029 17.7 0.0 0.0055 16.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 EMC84156.1 - 0.0096 15.5 0.0 0.017 14.7 0.0 1.4 1 0 0 1 1 1 1 GNAT acetyltransferase zf_UBZ PF18439.1 EMC84156.1 - 1.3 8.7 4.1 1.1 8.9 0.2 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger BIR PF00653.21 EMC84157.1 - 9.9e-24 83.8 1.3 1.4e-23 83.3 1.3 1.2 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain Fn3_assoc PF13287.6 EMC84158.1 - 6.7e-16 58.2 0.1 1.4e-15 57.2 0.1 1.6 1 0 0 1 1 1 1 Fn3 associated CHB_HEX_C_1 PF13290.6 EMC84158.1 - 7.4e-16 57.9 0.1 1.4e-15 57.0 0.1 1.5 1 0 0 1 1 1 1 Chitobiase/beta-hexosaminidase C-terminal domain DZR PF12773.7 EMC84158.1 - 4.9e-15 55.3 39.3 2.5e-07 30.6 16.1 3.5 2 1 1 3 3 3 3 Double zinc ribbon zinc_ribbon_2 PF13240.6 EMC84158.1 - 0.00021 20.9 16.8 0.0017 18.0 5.0 5.4 6 0 0 6 6 6 3 zinc-ribbon domain zf-RanBP PF00641.18 EMC84158.1 - 0.012 14.9 1.1 0.012 14.9 1.1 5.5 5 0 0 5 5 5 0 Zn-finger in Ran binding protein and others Mut7-C PF01927.16 EMC84158.1 - 0.34 11.0 6.1 0.42 10.7 1.7 2.7 2 0 0 2 2 2 0 Mut7-C RNAse domain zf-ribbon_3 PF13248.6 EMC84158.1 - 1.6 8.2 33.2 0.11 12.0 4.4 5.3 5 0 0 5 5 5 0 zinc-ribbon domain RNA_pol_Rpc34 PF05158.12 EMC84159.1 - 1e-104 350.6 0.3 1.2e-104 350.3 0.3 1.1 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit TrmB PF01978.19 EMC84159.1 - 0.00022 21.0 0.7 0.011 15.6 0.2 2.9 2 1 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB RPA_C PF08784.11 EMC84159.1 - 0.0036 17.9 1.1 1.3 9.7 0.0 3.3 3 0 0 3 3 3 1 Replication protein A C terminal CDC24_OB1 PF17246.2 EMC84159.1 - 0.015 15.4 0.0 0.046 13.8 0.0 1.9 2 0 0 2 2 2 0 Cell division control protein 24, OB domain 1 TFIIE_alpha PF02002.17 EMC84159.1 - 0.054 13.4 0.4 0.13 12.1 0.4 1.7 1 0 0 1 1 1 0 TFIIE alpha subunit Tyr_Deacylase PF02580.16 EMC84160.1 - 2.2e-51 174.1 0.0 2.8e-51 173.8 0.0 1.1 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Kinocilin PF15033.6 EMC84160.1 - 0.043 13.5 0.0 0.066 12.9 0.0 1.3 1 0 0 1 1 1 0 Kinocilin protein Collagen PF01391.18 EMC84163.1 - 0.00091 18.9 15.9 0.029 14.1 15.4 2.7 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) KLRAQ PF10205.9 EMC84164.1 - 7.4e-31 106.4 15.0 7.4e-31 106.4 15.0 2.3 2 0 0 2 2 2 1 Predicted coiled-coil domain-containing protein HP0268 PF18618.1 EMC84164.1 - 0.037 14.5 0.5 0.037 14.5 0.5 1.9 2 0 0 2 2 2 0 HP0268 YolD PF08863.10 EMC84164.1 - 0.1 12.7 2.6 0.17 12.0 0.9 2.2 2 0 0 2 2 2 0 YolD-like protein Tropomyosin_1 PF12718.7 EMC84164.1 - 0.26 11.5 28.4 0.18 11.9 16.7 2.4 1 1 1 2 2 2 0 Tropomyosin like ADIP PF11559.8 EMC84164.1 - 5 7.2 32.7 4.7 7.3 13.5 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Beta_helix PF13229.6 EMC84166.1 - 1.9e-78 261.8 69.5 1.1e-27 96.8 11.2 4.8 1 1 3 4 4 4 4 Right handed beta helix region NosD PF05048.13 EMC84166.1 - 3.9e-41 140.9 30.0 1.5e-17 63.7 8.8 3.9 1 1 3 4 4 4 4 Periplasmic copper-binding protein (NosD) F-box-like PF12937.7 EMC84166.1 - 6.7e-16 57.9 0.3 1.3e-15 57.0 0.3 1.5 1 0 0 1 1 1 1 F-box-like zf-UBR PF02207.20 EMC84166.1 - 4.6e-09 36.3 13.1 4.6e-09 36.3 13.1 2.1 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) F-box PF00646.33 EMC84166.1 - 5.1e-08 32.6 0.3 5.1e-08 32.6 0.3 1.8 2 0 0 2 2 2 1 F-box domain MutS_V PF00488.21 EMC84167.1 - 1.1e-71 240.7 0.0 1.9e-71 240.0 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EMC84167.1 - 3.8e-40 138.2 0.8 7.8e-40 137.1 0.0 1.9 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.20 EMC84167.1 - 5.1e-34 116.9 0.0 1.3e-33 115.6 0.0 1.7 1 0 0 1 1 1 1 MutS domain I PWWP PF00855.17 EMC84167.1 - 5.8e-22 77.9 0.0 2.2e-21 76.0 0.0 2.1 1 0 0 1 1 1 1 PWWP domain MutS_IV PF05190.18 EMC84167.1 - 9.3e-17 61.2 0.7 2.5e-16 59.8 0.2 2.1 2 0 0 2 2 2 1 MutS family domain IV MutS_II PF05188.17 EMC84167.1 - 1.6e-13 51.2 0.3 9.7e-13 48.6 0.3 2.3 1 1 0 1 1 1 1 MutS domain II Autoind_bind PF03472.15 EMC84167.1 - 0.093 12.2 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Autoinducer binding domain Ion_trans_2 PF07885.16 EMC84168.1 - 3.7e-30 103.7 21.6 2e-15 56.5 9.1 2.2 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 EMC84168.1 - 0.00063 19.1 15.9 0.0076 15.5 1.5 2.2 2 0 0 2 2 2 2 Ion transport protein MutS_V PF00488.21 EMC84169.1 - 1.4e-85 286.1 0.6 2.8e-85 285.1 0.6 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EMC84169.1 - 3.7e-37 128.4 1.7 3.7e-37 128.4 1.7 2.5 3 0 0 3 3 3 1 MutS domain III MutS_II PF05188.17 EMC84169.1 - 4.8e-22 78.7 0.2 1.5e-21 77.1 0.0 2.0 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 EMC84169.1 - 6.9e-21 74.4 2.7 1.9e-20 73.0 2.7 1.8 1 0 0 1 1 1 1 MutS family domain IV MutS_I PF01624.20 EMC84169.1 - 2.1e-05 24.7 0.0 7.1e-05 23.0 0.0 2.0 2 0 0 2 2 2 1 MutS domain I AAA_27 PF13514.6 EMC84169.1 - 0.0017 18.0 0.0 0.0056 16.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain DUF2935 PF11155.8 EMC84169.1 - 0.049 14.0 1.2 9.9 6.5 0.3 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF2935) Thyroglobulin_1 PF00086.18 EMC84170.1 - 1.4e-11 43.9 2.1 2.4e-11 43.1 2.1 1.4 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat Stevor PF17410.2 EMC84170.1 - 6.7e-05 22.6 0.0 0.00011 21.9 0.0 1.3 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame DUF4381 PF14316.6 EMC84170.1 - 0.0075 16.5 0.0 0.026 14.7 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4381) RIFIN PF02009.16 EMC84170.1 - 0.0081 16.1 0.4 0.0093 15.9 0.4 1.2 1 0 0 1 1 1 1 Rifin DAG1 PF05454.11 EMC84170.1 - 0.026 13.9 0.1 0.04 13.3 0.1 1.3 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) EphA2_TM PF14575.6 EMC84170.1 - 0.1 13.5 1.0 0.31 12.0 1.0 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Vpu PF00558.19 EMC84170.1 - 0.27 11.0 1.8 0.45 10.3 0.8 1.8 2 0 0 2 2 2 0 Vpu protein Spy1 PF11357.8 EMC84171.1 - 1.4e-59 200.1 5.5 1.9e-59 199.6 5.5 1.2 1 0 0 1 1 1 1 Cell cycle regulatory protein GCD14 PF08704.10 EMC84172.1 - 2.4e-21 76.5 0.0 2.9e-21 76.3 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 EMC84172.1 - 9.7e-10 38.6 0.0 1.2e-09 38.3 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EMC84172.1 - 3.6e-09 36.6 0.0 1.1e-08 35.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC84172.1 - 3.4e-07 30.9 0.0 6.6e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 EMC84172.1 - 6.6e-05 23.9 0.0 9.8e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC84172.1 - 0.0003 21.4 0.0 0.00052 20.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.12 EMC84172.1 - 0.0068 16.1 0.0 0.023 14.4 0.0 1.7 2 0 0 2 2 2 1 Cephalosporin hydroxylase Methyltransf_23 PF13489.6 EMC84172.1 - 0.011 15.6 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 EMC84172.1 - 0.011 14.8 0.0 0.017 14.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase FtsJ PF01728.19 EMC84172.1 - 0.021 14.9 0.0 0.036 14.2 0.0 1.3 1 1 0 1 1 1 0 FtsJ-like methyltransferase Ubie_methyltran PF01209.18 EMC84172.1 - 0.024 14.0 0.0 0.037 13.4 0.0 1.3 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family DOT1 PF08123.13 EMC84172.1 - 0.031 13.8 0.0 0.043 13.3 0.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 YcaO PF02624.16 EMC84172.1 - 0.059 12.6 0.0 0.078 12.2 0.0 1.1 1 0 0 1 1 1 0 YcaO cyclodehydratase, ATP-ad Mg2+-binding MTS PF05175.14 EMC84172.1 - 0.077 12.5 0.0 0.14 11.7 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.20 EMC84172.1 - 0.12 11.6 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase 7tm_1 PF00001.21 EMC84173.1 - 4.3e-14 52.5 7.2 4.8e-14 52.3 7.2 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC84173.1 - 0.0045 16.4 4.0 0.0045 16.4 4.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx COX1 PF00115.20 EMC84173.1 - 0.018 13.9 3.0 0.02 13.8 3.0 1.0 1 0 0 1 1 1 0 Cytochrome C and Quinol oxidase polypeptide I Bact_transglu_N PF08379.10 EMC84174.1 - 0.38 11.7 22.5 9.9 7.1 0.4 5.1 5 0 0 5 5 5 0 Bacterial transglutaminase-like N-terminal region RTC_insert PF05189.13 EMC84175.1 - 0.061 13.9 0.3 41 4.8 0.0 2.7 1 1 3 4 4 4 0 RNA 3'-terminal phosphate cyclase (RTC), insert domain MSG PF02349.15 EMC84176.1 - 0.00012 22.2 8.2 0.026 14.7 0.6 2.9 2 1 1 3 3 3 2 Major surface glycoprotein zf-C2HC_2 PF13913.6 EMC84178.1 - 4.4e-14 52.0 6.9 1.2e-08 34.6 0.6 2.7 2 0 0 2 2 2 2 zinc-finger of a C2HC-type Zf_RING PF16744.5 EMC84178.1 - 0.017 15.2 0.6 0.71 10.0 0.0 2.5 2 0 0 2 2 2 0 KIAA1045 RING finger DZR PF12773.7 EMC84178.1 - 0.018 15.1 11.8 0.089 12.8 2.4 3.3 3 0 0 3 3 3 0 Double zinc ribbon Rod_cone_degen PF15201.6 EMC84178.1 - 0.095 12.8 1.3 0.31 11.1 1.3 1.9 1 0 0 1 1 1 0 Progressive rod-cone degeneration zf-C2H2 PF00096.26 EMC84178.1 - 0.13 12.7 14.9 0.31 11.6 0.1 4.1 4 0 0 4 4 3 0 Zinc finger, C2H2 type TRAF6_Z2 PF18048.1 EMC84178.1 - 0.14 12.2 2.5 0.14 12.2 0.3 2.1 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 DUF2321 PF10083.9 EMC84178.1 - 0.23 11.1 2.1 0.8 9.3 2.1 1.9 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) zf-C2H2_4 PF13894.6 EMC84178.1 - 0.86 10.6 0.1 0.56 11.2 0.6 4.4 5 0 0 5 5 4 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC84178.1 - 1.3 9.4 4.7 8.6 6.8 0.2 3.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding HypA PF01155.19 EMC84178.1 - 3.1 7.8 9.4 5 7.2 1.9 3.0 3 0 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_6 PF13912.6 EMC84178.1 - 4.5 7.4 6.8 20 5.3 0.1 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger PKI PF02827.16 EMC84179.1 - 7.1e-30 103.0 0.5 8.3e-30 102.8 0.5 1.1 1 0 0 1 1 1 1 cAMP-dependent protein kinase inhibitor Pex2_Pex12 PF04757.14 EMC84180.1 - 5.4e-38 130.8 5.2 7.3e-38 130.4 5.2 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4 PF00097.25 EMC84180.1 - 3.1e-08 33.3 8.7 3.1e-08 33.3 8.7 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC84180.1 - 0.00011 22.0 5.3 0.00024 20.9 5.3 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EMC84180.1 - 0.00013 21.7 8.6 0.00013 21.7 8.6 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC84180.1 - 0.00025 21.0 7.1 0.00025 21.0 7.1 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EMC84180.1 - 0.00034 20.7 11.4 0.00091 19.3 11.4 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EMC84180.1 - 0.0048 17.2 8.3 0.014 15.7 8.3 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EMC84180.1 - 0.0049 16.7 8.4 0.0092 15.8 8.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC84180.1 - 0.0089 16.0 11.9 0.0089 16.0 11.9 2.4 2 0 0 2 2 2 1 zinc-RING finger domain RDD PF06271.12 EMC84180.1 - 0.041 14.1 0.4 0.13 12.4 0.4 1.7 1 1 0 1 1 1 0 RDD family DZR PF12773.7 EMC84180.1 - 0.91 9.6 7.6 2.3 8.3 7.6 1.7 1 0 0 1 1 1 0 Double zinc ribbon zf-RING_6 PF14835.6 EMC84180.1 - 3.2 7.7 7.6 1.1 9.2 4.2 1.9 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 EMC84180.1 - 3.8 7.9 11.5 1.1 9.6 8.2 1.8 2 0 0 2 2 2 0 RING-H2 zinc finger domain Hormone_recep PF00104.30 EMC84181.1 - 4.6e-42 143.9 0.2 7.8e-42 143.2 0.2 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 EMC84181.1 - 2.5e-24 85.5 12.6 4.9e-24 84.6 12.6 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) LCCL PF03815.19 EMC84182.1 - 4.3e-51 171.0 16.1 9.5e-27 93.0 0.4 3.2 3 0 0 3 3 3 2 LCCL domain CAP PF00188.26 EMC84182.1 - 1.3e-20 74.5 1.4 3.5e-20 73.1 1.4 1.8 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Rxt3 PF08642.10 EMC84182.1 - 0.0036 18.1 1.3 0.14 12.9 0.0 3.0 3 0 0 3 3 3 1 Histone deacetylation protein Rxt3 DUF2889 PF11136.8 EMC84182.1 - 0.063 13.6 0.2 0.16 12.3 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2889) CAP PF00188.26 EMC84183.1 - 2.4e-25 89.8 2.2 3.8e-25 89.2 2.2 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family GST_N_3 PF13417.6 EMC84184.1 - 3e-11 43.5 0.0 7e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EMC84184.1 - 6.8e-11 42.4 0.1 1.9e-10 40.9 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EMC84184.1 - 2.6e-09 36.9 0.0 5.3e-09 36.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EMC84184.1 - 1.5e-08 34.8 0.1 5e-08 33.1 0.1 2.0 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EMC84184.1 - 2.2e-08 34.3 0.0 5.4e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EMC84184.1 - 4.1e-07 30.1 0.0 3.9e-06 27.0 0.0 2.6 3 1 0 3 3 3 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 EMC84184.1 - 0.0022 18.3 0.0 0.0059 16.9 0.0 1.7 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 EMC84184.1 - 0.025 15.3 0.0 0.05 14.3 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain DUF1617 PF07761.12 EMC84184.1 - 0.035 14.2 1.0 0.059 13.4 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1617) DUF3206 PF11472.8 EMC84184.1 - 0.046 13.7 0.0 0.079 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3206) Fmp27_WPPW PF10359.9 EMC84184.1 - 0.08 11.8 0.1 0.11 11.3 0.1 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain MCR_C PF04609.12 EMC84184.1 - 0.13 11.4 0.2 0.2 10.7 0.2 1.3 1 0 0 1 1 1 0 Methyl-coenzyme M reductase operon protein C CCDC-167 PF15188.6 EMC84184.1 - 3.9 7.9 7.1 13 6.2 0.2 2.5 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 MORN PF02493.20 EMC84185.1 - 1.7e-17 62.2 17.2 3.3e-07 29.8 0.8 3.8 3 0 0 3 3 3 3 MORN repeat Alanine_zipper PF11839.8 EMC84185.1 - 2.7 8.4 21.6 6.1 7.3 21.6 1.5 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein TMEM70 PF06979.12 EMC84186.1 - 2e-56 190.0 7.8 2.5e-56 189.7 7.8 1.1 1 0 0 1 1 1 1 Assembly, mitochondrial proton-transport ATP synth complex Skp1_POZ PF03931.15 EMC84187.1 - 3.1e-11 43.3 0.0 4.3e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain PTAC PF06130.12 EMC84187.1 - 0.13 12.5 0.0 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 Phosphate propanoyltransferase UQ_con PF00179.26 EMC84188.1 - 3.3e-34 117.5 0.2 3.6e-34 117.4 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EMC84188.1 - 0.016 15.1 0.0 0.02 14.8 0.0 1.2 1 0 0 1 1 1 0 UEV domain Prok-E2_A PF14457.6 EMC84188.1 - 0.11 12.2 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family A dsrm PF00035.26 EMC84189.1 - 3e-50 168.8 2.6 2.5e-13 50.5 0.1 4.6 4 0 0 4 4 4 4 Double-stranded RNA binding motif Staufen_C PF16482.5 EMC84189.1 - 1.1e-20 73.8 0.2 1.6e-16 60.4 0.0 4.6 5 0 0 5 5 5 1 Staufen C-terminal domain DND1_DSRM PF14709.7 EMC84189.1 - 1.9e-07 31.2 5.1 0.15 12.3 0.1 5.3 4 2 0 4 4 4 2 double strand RNA binding domain from DEAD END PROTEIN 1 Dicer_dimer PF03368.14 EMC84189.1 - 0.013 15.6 1.7 54 4.0 0.0 4.3 4 0 0 4 4 4 0 Dicer dimerisation domain TMEM169 PF15052.6 EMC84190.1 - 6.9e-64 213.8 8.3 8.9e-64 213.5 8.3 1.1 1 0 0 1 1 1 1 TMEM169 protein family Ku_N PF03731.15 EMC84191.1 - 2.8e-58 197.3 1.1 2.8e-58 197.3 1.1 2.3 2 0 0 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain Ku PF02735.16 EMC84191.1 - 3.1e-45 154.4 1.4 5.6e-45 153.5 1.4 1.5 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_PK_bind PF08785.11 EMC84191.1 - 2.8e-31 108.2 1.8 2.8e-31 108.2 1.8 2.8 3 0 0 3 3 3 1 Ku C terminal domain like Ku_C PF03730.14 EMC84191.1 - 2e-20 73.2 2.0 9.5e-20 71.1 2.0 2.3 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm VWA PF00092.28 EMC84191.1 - 0.011 16.0 0.2 0.041 14.1 0.0 2.0 2 0 0 2 2 2 0 von Willebrand factor type A domain BLM10_mid PF16507.5 EMC84191.1 - 0.1 11.2 0.2 0.16 10.6 0.2 1.2 1 0 0 1 1 1 0 Proteasome-substrate-size regulator, mid region HARP PF07443.13 EMC84192.1 - 3.7e-52 173.8 0.9 5.8e-25 86.7 0.1 2.6 2 0 0 2 2 2 2 HepA-related protein (HARP) SNF2_N PF00176.23 EMC84192.1 - 1.1e-25 90.1 0.0 1.9e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EMC84192.1 - 1.9e-15 57.2 0.1 6.3e-15 55.5 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EMC84192.1 - 6.7e-07 28.8 0.3 1.1e-05 24.8 0.1 2.2 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 EMC84192.1 - 2.7e-06 27.5 0.1 0.00023 21.2 0.0 3.1 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 EMC84192.1 - 0.07 13.1 0.1 0.93 9.5 0.0 2.5 2 1 0 2 2 2 0 Flavivirus DEAD domain TK PF00265.18 EMC84192.1 - 0.15 11.9 0.1 0.45 10.3 0.0 1.9 2 0 0 2 2 2 0 Thymidine kinase Ribosomal_L37ae PF01780.19 EMC84193.1 - 3.9e-47 158.2 11.2 4.4e-47 158.1 11.2 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-RING_13 PF17977.1 EMC84193.1 - 0.0047 17.0 4.8 0.0073 16.4 4.2 1.6 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain Elf1 PF05129.13 EMC84193.1 - 0.011 15.8 0.3 0.016 15.3 0.3 1.4 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Rsm1 PF08600.10 EMC84193.1 - 0.013 15.6 0.6 0.019 15.1 0.6 1.3 1 0 0 1 1 1 0 Rsm1-like Zn_Tnp_IS1595 PF12760.7 EMC84193.1 - 0.052 13.5 1.8 0.076 13.0 1.8 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-C4_ClpX PF06689.13 EMC84193.1 - 0.14 12.1 4.1 0.43 10.5 4.1 1.9 1 1 0 1 1 1 0 ClpX C4-type zinc finger zf-BED PF02892.15 EMC84193.1 - 0.77 9.8 6.0 5.3 7.2 0.7 2.2 1 1 1 2 2 2 0 BED zinc finger Thyroglobulin_1 PF00086.18 EMC84194.1 - 4.8e-18 64.6 0.8 4.8e-18 64.6 0.8 1.6 2 0 0 2 2 2 1 Thyroglobulin type-1 repeat Thyroglobulin_1 PF00086.18 EMC84195.1 - 3e-06 26.8 0.3 6.9e-06 25.6 0.3 1.6 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat SH2 PF00017.24 EMC84196.1 - 3e-09 36.8 0.0 5.4e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 SH2 domain RUN PF02759.19 EMC84197.1 - 6.1e-11 42.4 0.3 6.8e-11 42.3 0.3 1.0 1 0 0 1 1 1 1 RUN domain 7tm_1 PF00001.21 EMC84198.1 - 3.8e-56 190.3 13.8 3.8e-56 190.3 13.8 1.4 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC84198.1 - 3.5e-08 33.2 12.8 4.9e-08 32.7 12.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx SpoIIM PF01944.17 EMC84198.1 - 0.0028 17.7 2.5 0.0028 17.7 2.5 2.2 2 1 0 2 2 2 1 Stage II sporulation protein M ABC2_membrane_5 PF13346.6 EMC84198.1 - 0.14 11.6 14.9 0.92 9.0 8.2 2.7 2 1 0 2 2 2 0 ABC-2 family transporter protein WD40 PF00400.32 EMC84199.1 - 4.3e-31 106.5 14.8 8.7e-07 29.6 0.3 8.0 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC84199.1 - 4.8e-20 71.6 2.0 2e-06 28.0 0.0 5.5 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC84199.1 - 2.5e-08 34.0 0.3 0.0076 16.1 0.1 3.7 2 1 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EMC84199.1 - 9.7e-06 25.1 0.0 0.16 11.3 0.0 2.9 3 0 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 EMC84199.1 - 0.018 13.7 0.1 0.5 8.9 0.0 2.6 3 0 0 3 3 3 0 Nucleoporin Nup120/160 PQQ PF01011.21 EMC84199.1 - 0.019 14.9 4.7 1.5 8.9 0.0 4.4 4 0 0 4 4 4 0 PQQ enzyme repeat Ge1_WD40 PF16529.5 EMC84199.1 - 0.052 12.5 0.2 0.58 9.1 0.0 2.7 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF4748 PF15932.5 EMC84200.1 - 3.3e-20 71.6 0.0 4.3e-20 71.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4748) Bax1-I PF01027.20 EMC84201.1 - 2.5e-25 89.5 25.4 7.4e-25 88.0 25.4 1.6 1 1 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF2070 PF09843.9 EMC84201.1 - 0.77 8.0 13.0 1 7.6 13.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF2157 PF09925.9 EMC84201.1 - 0.89 9.3 7.6 2.1 8.1 7.6 1.6 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) Wzy_C PF04932.15 EMC84201.1 - 5 6.7 10.3 1.8 8.2 0.1 3.1 2 1 1 3 3 3 0 O-Antigen ligase TssN PF17555.2 EMC84201.1 - 5.2 6.4 10.7 9.7 5.5 10.7 1.3 1 0 0 1 1 1 0 Type VI secretion system, TssN Lactamase_B PF00753.27 EMC84202.1 - 1.1e-08 35.4 0.0 1.5e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EMC84202.1 - 2.2e-05 24.0 0.0 3.1e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Nramp PF01566.18 EMC84204.1 - 6.4e-115 383.9 13.8 6.4e-115 383.9 13.8 1.9 2 0 0 2 2 2 1 Natural resistance-associated macrophage protein NIF PF03031.18 EMC84205.1 - 4.4e-53 179.2 0.0 5.2e-53 179.0 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase PH_RBD PF12068.8 EMC84205.1 - 0.094 12.2 0.0 0.94 8.9 0.0 2.3 2 1 1 3 3 3 0 Rab-binding domain (RBD) Gelsolin PF00626.22 EMC84206.1 - 9.4e-103 336.2 0.0 1.9e-18 66.1 0.0 6.3 6 0 0 6 6 6 6 Gelsolin repeat VHP PF02209.19 EMC84206.1 - 1.2e-14 54.1 1.3 2.6e-14 53.0 1.3 1.6 1 0 0 1 1 1 1 Villin headpiece domain UCH PF00443.29 EMC84207.1 - 6.3e-59 199.6 0.8 1.1e-58 198.8 0.8 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_N PF16674.5 EMC84207.1 - 4.9e-44 148.6 0.0 1.1e-43 147.5 0.0 1.6 1 0 0 1 1 1 1 N-terminal of ubiquitin carboxyl-terminal hydrolase 37 UCH_1 PF13423.6 EMC84207.1 - 4.5e-09 36.3 27.1 1.8e-07 31.1 21.9 4.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UIM PF02809.20 EMC84207.1 - 2e-08 33.6 20.7 0.00025 20.7 0.2 3.9 3 0 0 3 3 3 3 Ubiquitin interaction motif Peptidase_C98 PF15499.6 EMC84207.1 - 0.022 14.2 5.4 0.18 11.2 3.1 3.0 2 1 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Elongin_A PF06881.11 EMC84207.1 - 3.4 8.2 11.3 0.66 10.5 6.8 2.2 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Rcd1 PF04078.13 EMC84208.1 - 1.3e-130 434.3 0.6 1.5e-130 434.2 0.6 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like BCS1_N PF08740.11 EMC84209.1 - 3.6e-44 151.0 2.0 5e-44 150.5 2.0 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EMC84209.1 - 2.8e-20 73.1 0.0 6e-20 72.0 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EMC84209.1 - 0.00046 20.6 0.3 0.0022 18.4 0.2 2.2 1 1 1 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.22 EMC84209.1 - 0.00088 19.6 0.0 0.0026 18.2 0.0 1.9 1 1 0 1 1 1 1 RNA helicase DUF815 PF05673.13 EMC84209.1 - 0.00091 18.5 0.0 0.0021 17.2 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Rad17 PF03215.15 EMC84209.1 - 0.0032 17.4 0.0 0.012 15.5 0.0 1.8 1 1 1 2 2 2 1 Rad17 P-loop domain ABC_tran PF00005.27 EMC84209.1 - 0.015 15.8 0.0 0.03 14.8 0.0 1.6 1 0 0 1 1 1 0 ABC transporter RuvB_N PF05496.12 EMC84209.1 - 0.018 14.8 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_11 PF13086.6 EMC84209.1 - 0.022 14.5 0.0 0.045 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EMC84209.1 - 0.026 14.3 0.1 0.15 11.8 0.0 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_5 PF07728.14 EMC84209.1 - 0.034 14.1 0.0 0.088 12.8 0.0 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EMC84209.1 - 0.042 14.0 0.0 0.09 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EMC84209.1 - 0.06 13.9 0.0 0.17 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EMC84209.1 - 0.12 12.3 0.0 0.34 10.8 0.0 1.7 1 1 0 1 1 1 0 RsgA GTPase AAA_25 PF13481.6 EMC84209.1 - 0.14 11.7 0.0 0.36 10.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EMC84209.1 - 0.14 11.8 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EMC84209.1 - 0.21 11.7 0.0 0.78 9.8 0.0 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase ATPase_2 PF01637.18 EMC84209.1 - 0.22 11.4 0.0 0.44 10.4 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RWD PF05773.22 EMC84210.1 - 3.7e-13 49.8 0.1 7.1e-13 48.9 0.1 1.4 1 0 0 1 1 1 1 RWD domain zf-RING_2 PF13639.6 EMC84210.1 - 1.2e-06 28.8 7.5 7.8e-06 26.1 7.5 2.2 1 1 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EMC84210.1 - 6e-06 25.9 5.1 6e-06 25.9 5.1 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_5 PF14634.6 EMC84210.1 - 4.8e-05 23.2 7.4 0.00012 22.0 7.4 1.7 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EMC84210.1 - 0.004 17.0 7.4 0.0062 16.4 3.4 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC84210.1 - 0.0089 15.9 5.1 0.087 12.7 5.4 2.2 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC84210.1 - 0.013 15.5 6.3 0.024 14.7 1.0 2.4 2 0 0 2 2 2 0 RING-type zinc-finger zf-rbx1 PF12678.7 EMC84210.1 - 0.031 14.6 1.9 0.031 14.6 1.9 2.5 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EMC84210.1 - 0.22 11.6 4.7 0.37 10.9 1.8 2.3 1 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zf_RING PF16744.5 EMC84210.1 - 0.67 10.1 4.5 1.6 8.9 4.3 1.7 1 1 0 1 1 1 0 KIAA1045 RING finger TTL PF03133.15 EMC84211.1 - 2.9e-101 338.5 0.1 4.6e-101 337.8 0.1 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EMC84211.1 - 1.2e-06 28.0 0.1 0.00026 20.3 0.0 2.9 3 1 0 3 3 3 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 EMC84211.1 - 0.0012 18.2 0.0 0.011 15.0 0.0 2.1 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp zf-CHC2 PF01807.20 EMC84211.1 - 0.15 11.9 0.1 0.35 10.7 0.1 1.5 1 0 0 1 1 1 0 CHC2 zinc finger CBS PF00571.28 EMC84212.1 - 2.4e-35 120.8 3.9 2.3e-11 44.0 0.2 4.4 4 0 0 4 4 4 4 CBS domain IF3_N PF05198.16 EMC84212.1 - 0.13 12.5 0.1 18 5.7 0.0 2.6 2 0 0 2 2 2 0 Translation initiation factor IF-3, N-terminal domain p450 PF00067.22 EMC84213.1 - 4e-100 335.7 0.0 5e-100 335.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 wnt PF00110.19 EMC84214.1 - 1.2e-118 396.2 16.6 1.6e-118 395.8 16.6 1.1 1 0 0 1 1 1 1 wnt family wnt PF00110.19 EMC84215.1 - 3.9e-123 410.9 18.6 4.4e-123 410.8 18.6 1.0 1 0 0 1 1 1 1 wnt family CDK5_activator PF03261.15 EMC84216.1 - 1.1e-42 146.9 0.0 1.4e-42 146.6 0.0 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase 5 activator protein Ets PF00178.22 EMC84217.1 - 2.8e-36 123.8 0.4 3.9e-36 123.4 0.4 1.2 1 0 0 1 1 1 1 Ets-domain Crystall PF00030.19 EMC84218.1 - 4.3e-38 129.4 6.7 1.2e-27 95.9 0.4 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin IL4_i_Ig PF18258.1 EMC84218.1 - 0.0026 17.9 2.0 0.46 10.7 0.2 2.7 2 1 1 3 3 3 2 Interleukin-4 inducing immunoglobulin-binding domain Homeodomain PF00046.29 EMC84219.1 - 1.8e-22 79.0 7.2 2.6e-22 78.4 7.2 1.3 1 0 0 1 1 1 1 Homeodomain QLQ PF08880.11 EMC84219.1 - 0.00098 18.8 0.4 0.0015 18.2 0.4 1.3 1 0 0 1 1 1 1 QLQ Hint PF01079.20 EMC84220.1 - 4e-72 242.2 0.0 4.9e-72 241.9 0.0 1.1 1 0 0 1 1 1 1 Hint module HH_signal PF01085.18 EMC84220.1 - 1.1e-49 168.2 0.3 1.5e-49 167.8 0.3 1.2 1 0 0 1 1 1 1 Hedgehog amino-terminal signalling domain Peptidase_M15_3 PF08291.11 EMC84220.1 - 0.00044 20.3 0.0 0.00067 19.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase M15 XLF PF09302.11 EMC84221.1 - 1.8e-31 109.7 0.0 5e-31 108.3 0.0 1.8 1 1 0 1 1 1 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component Xan_ur_permease PF00860.20 EMC84222.1 - 1.1e-67 228.5 16.3 2.2e-67 227.5 16.3 1.5 1 1 0 1 1 1 1 Permease family Bap31 PF05529.12 EMC84222.1 - 0.071 13.0 0.1 0.17 11.7 0.1 1.6 1 0 0 1 1 1 0 Bap31/Bap29 transmembrane region DUF3446 PF11928.8 EMC84222.1 - 1.3 9.3 3.8 1.4 9.2 0.1 2.8 3 0 0 3 3 3 0 Early growth response N-terminal domain zf-AN1 PF01428.16 EMC84224.1 - 1.2e-19 70.2 25.1 9.9e-12 44.8 10.2 2.6 3 0 0 3 3 3 2 AN1-like Zinc finger UIM PF02809.20 EMC84224.1 - 0.00048 19.9 6.4 0.00048 19.9 6.4 2.5 2 0 0 2 2 2 1 Ubiquitin interaction motif Transp_Tc5_C PF04236.15 EMC84224.1 - 0.15 12.4 15.5 1.7 9.0 5.0 2.4 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain C1_4 PF07975.12 EMC84224.1 - 3.2 8.1 16.3 7.3 6.9 6.2 2.7 2 0 0 2 2 2 0 TFIIH C1-like domain MTABC_N PF16185.5 EMC84225.1 - 1.8e-42 145.5 3.4 4.5e-42 144.2 3.4 1.7 1 0 0 1 1 1 1 Mitochondrial ABC-transporter N-terminal five TM region ABC_membrane PF00664.23 EMC84225.1 - 1.2e-37 130.1 11.9 1.8e-37 129.5 11.9 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EMC84225.1 - 1.6e-34 119.4 0.0 2.7e-34 118.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EMC84225.1 - 2.3e-06 27.2 0.1 0.00013 21.5 0.1 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EMC84225.1 - 5.6e-05 23.6 0.0 0.00012 22.5 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 EMC84225.1 - 0.0013 18.5 0.1 0.0031 17.2 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EMC84225.1 - 0.0013 18.7 0.0 0.0025 17.7 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 EMC84225.1 - 0.0016 18.8 0.0 0.01 16.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EMC84225.1 - 0.0016 18.8 0.0 0.034 14.6 0.0 2.5 2 1 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 EMC84225.1 - 0.0086 15.9 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system Acyl-CoA_dh_1 PF00441.24 EMC84225.1 - 0.017 15.3 0.1 0.063 13.5 0.0 1.8 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain AAA_24 PF13479.6 EMC84225.1 - 0.025 14.3 0.0 0.056 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EMC84225.1 - 0.04 13.9 0.2 0.61 10.1 0.0 2.5 1 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 EMC84225.1 - 0.048 12.9 0.0 0.098 11.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_30 PF13604.6 EMC84225.1 - 0.056 13.2 0.0 0.11 12.2 0.0 1.5 1 1 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 EMC84225.1 - 0.09 13.0 0.3 1.9 8.8 0.3 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_33 PF13671.6 EMC84225.1 - 0.1 12.7 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 EMC84225.1 - 0.11 11.6 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_23 PF13476.6 EMC84225.1 - 0.11 12.9 0.0 0.25 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EMC84225.1 - 0.12 12.3 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain Septin PF00735.18 EMC84225.1 - 0.14 11.4 0.0 0.26 10.5 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_15 PF13175.6 EMC84225.1 - 0.18 11.5 0.0 0.48 10.1 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain APG9 PF04109.16 EMC84227.1 - 9.7e-172 572.3 13.2 1.2e-171 572.0 13.2 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 EMP24_GP25L PF01105.24 EMC84227.1 - 0.12 12.3 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Glyco_hydro_35 PF01301.19 EMC84228.1 - 5.3e-92 308.8 0.0 1.1e-91 307.7 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 EMC84228.1 - 2.4e-11 43.6 0.0 3.5e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 Beta-galactosidase BetaGal_dom4_5 PF13364.6 EMC84228.1 - 7e-09 36.3 0.0 4.3e-08 33.7 0.0 2.2 2 0 0 2 2 2 1 Beta-galactosidase jelly roll domain Pkinase PF00069.25 EMC84229.1 - 7.3e-42 143.5 0.0 8.7e-42 143.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC84229.1 - 5.1e-26 91.5 0.0 6.4e-26 91.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMC84229.1 - 4.8e-06 26.1 0.0 6.5e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMC84229.1 - 5.3e-05 23.3 0.4 0.056 13.3 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EMC84229.1 - 0.0016 17.8 0.0 0.0021 17.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Tubulin PF00091.25 EMC84230.1 - 5.5e-68 229.1 0.0 7.6e-68 228.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EMC84230.1 - 2.6e-52 176.3 0.0 4.6e-52 175.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EMC84230.1 - 0.00096 18.9 0.0 0.0018 18.0 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin PF00091.25 EMC84231.1 - 1.1e-66 224.8 0.0 1.5e-66 224.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EMC84231.1 - 3.6e-52 175.8 0.0 7.6e-52 174.8 0.0 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EMC84231.1 - 0.0012 18.5 0.0 0.0022 17.7 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Peptidase_M18 PF02127.15 EMC84232.1 - 4.7e-156 519.9 0.0 5.3e-156 519.7 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 EMC84232.1 - 7.1e-08 31.8 0.0 1.1e-05 24.6 0.0 2.5 3 0 0 3 3 3 2 M42 glutamyl aminopeptidase Filament PF00038.21 EMC84233.1 - 8.4e-53 180.0 25.7 9.9e-53 179.7 25.7 1.1 1 0 0 1 1 1 1 Intermediate filament protein Filament_head PF04732.14 EMC84233.1 - 3.6e-26 91.9 10.7 5.6e-26 91.2 10.7 1.3 1 0 0 1 1 1 1 Intermediate filament head (DNA binding) region FAP206 PF12018.8 EMC84233.1 - 0.11 11.9 12.8 0.039 13.5 4.4 2.1 1 1 1 2 2 2 0 Domain of unknown function Golgin_A5 PF09787.9 EMC84233.1 - 0.13 11.7 20.6 0.18 11.2 20.6 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 T6PP_N PF18572.1 EMC84233.1 - 0.16 11.8 9.5 0.52 10.2 9.5 2.0 1 1 0 1 1 1 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain Jnk-SapK_ap_N PF09744.9 EMC84233.1 - 0.16 12.2 24.4 0.043 14.0 14.9 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 KLRAQ PF10205.9 EMC84233.1 - 0.31 11.3 15.5 0.053 13.8 10.9 2.0 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein TPR_MLP1_2 PF07926.12 EMC84233.1 - 0.36 10.9 24.6 0.81 9.7 17.3 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein SHE3 PF17078.5 EMC84233.1 - 0.52 10.0 15.4 0.9 9.2 15.4 1.4 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 Exonuc_VII_L PF02601.15 EMC84233.1 - 1.1 8.8 14.8 0.44 10.1 10.8 1.9 1 1 1 2 2 2 0 Exonuclease VII, large subunit DUF4407 PF14362.6 EMC84233.1 - 1.3 8.3 13.9 3.3 7.0 13.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) bZIP_1 PF00170.21 EMC84233.1 - 1.4 9.1 12.8 0.81 9.8 1.5 3.6 3 1 0 3 3 3 0 bZIP transcription factor DUF1664 PF07889.12 EMC84233.1 - 1.4 8.9 10.2 0.19 11.8 3.0 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DUF5082 PF16888.5 EMC84233.1 - 2 8.7 11.8 1.6 9.0 9.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) Mis14 PF08641.12 EMC84233.1 - 3 8.2 17.4 47 4.3 17.4 2.3 1 1 0 1 1 1 0 Kinetochore protein Mis14 like Spc7 PF08317.11 EMC84233.1 - 3.8 6.3 24.1 2 7.3 3.7 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Baculo_PEP_C PF04513.12 EMC84233.1 - 4 7.5 8.9 1.7 8.7 4.6 2.3 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Rho_Binding PF08912.11 EMC84233.1 - 6.9 7.6 21.4 1.8 9.5 1.2 3.2 3 0 0 3 3 3 0 Rho Binding Pdase_M17_N2 PF18295.1 EMC84235.1 - 0.11 12.8 0.2 0.14 12.4 0.2 1.2 1 0 0 1 1 1 0 M17 aminopeptidase N-terminal domain 2 NTP_transferase PF00483.23 EMC84236.1 - 4e-17 62.6 0.0 6e-17 62.0 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EMC84236.1 - 0.00031 20.3 11.5 0.2 11.4 3.1 4.2 2 1 1 3 3 3 2 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 EMC84236.1 - 0.017 13.3 0.1 0.024 12.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 EMC84236.1 - 0.27 11.0 2.7 2.8 7.8 2.9 2.6 2 1 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase RhoGAP PF00620.27 EMC84237.1 - 2.1e-37 128.3 0.0 2.6e-37 128.0 0.0 1.1 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.22 EMC84237.1 - 3.7e-06 26.7 4.5 7.1e-06 25.8 4.5 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 EMC84237.1 - 0.42 10.5 6.2 0.84 9.6 6.2 1.5 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.6 EMC84237.1 - 0.88 9.5 6.0 2.3 8.2 6.0 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-C4H2 PF10146.9 EMC84238.1 - 0.021 15.1 0.3 0.022 15.1 0.3 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein Rootletin PF15035.6 EMC84238.1 - 0.048 13.7 7.5 0.062 13.3 7.5 1.1 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion PVL_ORF50 PF07768.11 EMC84238.1 - 0.49 10.7 5.0 0.69 10.2 5.0 1.2 1 0 0 1 1 1 0 PVL ORF-50-like family ASC PF00858.24 EMC84239.1 - 1.6e-27 96.6 0.0 1.8e-27 96.4 0.0 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel ASC PF00858.24 EMC84240.1 - 1e-105 354.3 0.0 1.4e-105 353.9 0.0 1.2 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel I-set PF07679.16 EMC84241.1 - 1.9e-104 341.9 0.0 3.3e-17 62.3 0.0 13.3 12 1 0 12 12 12 12 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC84241.1 - 2.8e-83 274.5 0.0 2.3e-10 40.9 0.0 12.1 12 0 0 12 12 12 9 Immunoglobulin domain Ig_2 PF13895.6 EMC84241.1 - 4.9e-63 209.4 0.0 1.3e-08 35.0 0.0 11.4 11 0 0 11 11 11 8 Immunoglobulin domain ig PF00047.25 EMC84241.1 - 1.9e-52 175.4 0.0 2.9e-06 27.3 0.0 11.5 11 0 0 11 11 11 9 Immunoglobulin domain V-set PF07686.17 EMC84241.1 - 4.6e-34 116.9 16.1 0.00043 20.4 0.0 16.8 14 5 3 18 18 18 6 Immunoglobulin V-set domain Izumo-Ig PF16706.5 EMC84241.1 - 8.5e-16 57.8 0.2 0.012 15.7 0.0 9.7 10 0 0 10 10 10 3 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 EMC84241.1 - 2.8e-15 56.5 0.0 1.9 9.0 0.0 11.1 12 1 0 12 12 12 4 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 EMC84241.1 - 4.9e-15 54.8 0.0 0.58 9.8 0.0 8.4 8 0 0 8 8 8 3 Immunoglobulin domain Ig_4 PF16680.5 EMC84241.1 - 2.1e-14 53.5 0.0 2.5 8.4 0.0 10.3 10 3 0 10 10 10 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 EMC84241.1 - 2e-11 43.8 4.0 0.0014 18.7 0.0 6.3 7 0 0 7 7 7 3 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 EMC84241.1 - 1.8e-09 37.8 1.1 1.1 9.6 0.0 7.2 7 0 0 7 7 7 2 Immunoglobulin C1-set domain BiPBP_C PF06832.12 EMC84241.1 - 1.6e-08 34.4 2.2 9.7 6.3 0.0 8.2 8 1 1 9 9 9 1 Penicillin-Binding Protein C-terminus Family Adeno_E3_CR1 PF02440.15 EMC84241.1 - 3.5e-05 23.5 0.0 0.85 9.4 0.0 6.6 10 0 0 10 10 10 1 Adenovirus E3 region protein CR1 C2-set PF05790.15 EMC84241.1 - 0.00077 19.6 3.5 55 4.0 0.0 7.1 9 0 0 9 9 9 0 Immunoglobulin C2-set domain Ig_C17orf99 PF17736.1 EMC84241.1 - 0.002 18.1 0.0 29 4.8 0.0 6.1 8 0 0 8 8 7 0 C17orf99 Ig domain TGF_beta PF00019.20 EMC84243.1 - 2.2e-15 57.5 0.9 2.4e-14 54.1 0.9 2.3 1 1 0 1 1 1 1 Transforming growth factor beta like domain LIP1 PF15904.5 EMC84244.1 - 4.2e-36 123.2 2.1 1.1e-35 121.9 2.1 1.8 1 0 0 1 1 1 1 LKB1 serine/threonine kinase interacting protein 1 LRR_8 PF13855.6 EMC84244.1 - 1.2e-10 41.0 18.3 2.7e-05 23.9 5.6 3.7 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EMC84244.1 - 9.6e-10 38.6 19.7 2.1e-06 28.0 1.3 5.3 4 3 3 7 7 7 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC84244.1 - 8.7e-06 25.3 2.9 2.4e-05 23.9 2.6 1.8 1 1 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.6 EMC84244.1 - 0.54 10.4 13.5 0.73 10.0 0.1 6.1 6 0 0 6 6 6 0 Leucine Rich repeat LRR_1 PF00560.33 EMC84244.1 - 1.4 9.8 20.7 41 5.3 0.1 7.8 7 1 0 7 7 7 0 Leucine Rich Repeat HCO3_cotransp PF00955.21 EMC84245.1 - 3.4e-204 679.4 23.4 8.3e-201 668.2 23.4 2.3 1 1 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 EMC84245.1 - 6e-106 354.2 0.5 6e-106 354.2 0.5 2.5 3 0 0 3 3 3 1 Band 3 cytoplasmic domain PTS_EIIA_2 PF00359.22 EMC84245.1 - 0.00018 21.4 0.0 0.00036 20.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 NPR3 PF03666.13 EMC84245.1 - 0.015 14.1 9.2 0.053 12.3 7.7 2.2 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Paf1 PF03985.13 EMC84245.1 - 0.73 8.8 15.5 1.7 7.6 15.5 1.5 1 0 0 1 1 1 0 Paf1 DUF1754 PF08555.10 EMC84245.1 - 6 7.7 20.6 3.1 8.7 10.0 2.7 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) Lectin_C PF00059.21 EMC84246.1 - 1.7e-126 414.8 49.1 2.4e-17 63.6 0.5 8.6 8 0 0 8 8 8 8 Lectin C-type domain fn2 PF00040.19 EMC84246.1 - 2e-15 56.8 13.1 2e-15 56.8 13.1 2.7 2 0 0 2 2 2 1 Fibronectin type II domain UL45 PF05473.12 EMC84246.1 - 9.6e-15 54.8 5.1 0.00022 20.9 0.1 6.9 6 1 0 6 6 6 4 UL45 protein, carbohydrate-binding C-type lectin-like Xlink PF00193.17 EMC84246.1 - 0.00011 22.6 9.3 0.86 10.0 0.0 7.2 7 1 0 7 7 7 1 Extracellular link domain Chordopox_A33R PF05966.12 EMC84246.1 - 0.00033 20.0 3.4 0.039 13.2 0.2 3.9 4 0 0 4 4 4 1 Chordopoxvirus A33R protein rhaM PF05336.13 EMC84246.1 - 0.049 13.7 0.2 0.16 12.1 0.2 1.9 1 0 0 1 1 1 0 L-rhamnose mutarotase Integrin_beta PF00362.18 EMC84247.1 - 1e-109 366.0 0.0 1.6e-109 365.4 0.0 1.3 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.11 EMC84247.1 - 5e-19 67.7 0.4 8.4e-19 67.0 0.4 1.4 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.12 EMC84247.1 - 5.7e-14 52.4 6.1 5.7e-14 52.4 6.1 4.5 5 1 2 7 7 7 1 Integrin beta tail domain PSI_integrin PF17205.3 EMC84247.1 - 4.8e-13 48.6 8.2 4.8e-13 48.6 8.2 5.7 6 2 0 6 6 6 1 Integrin plexin domain I-EGF_1 PF18372.1 EMC84247.1 - 1.1e-11 44.6 28.1 3.8e-11 42.9 7.9 7.1 8 0 0 8 8 8 4 Integrin beta epidermal growth factor like domain 1 EGF_2 PF07974.13 EMC84247.1 - 8.8e-05 22.8 40.8 0.00021 21.6 17.9 8.4 8 2 2 10 10 10 4 EGF-like domain Cupredoxin_1 PF13473.6 EMC84247.1 - 0.085 13.0 0.0 0.37 10.9 0.0 2.0 2 0 0 2 2 2 0 Cupredoxin-like domain RRM_1 PF00076.22 EMC84248.1 - 4.6e-33 112.9 0.0 3e-16 59.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 EMC84248.1 - 0.00069 19.8 0.0 0.96 9.7 0.0 2.4 2 0 0 2 2 2 2 BRCA1-associated protein 2 RRM_7 PF16367.5 EMC84248.1 - 0.14 12.3 0.0 15 5.8 0.0 2.5 2 1 0 2 2 2 0 RNA recognition motif JAB PF01398.21 EMC84249.1 - 9.5e-33 112.7 0.1 2.6e-32 111.2 0.0 1.8 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EMC84249.1 - 4.4e-16 59.3 1.3 7.8e-16 58.5 1.3 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 EMC84249.1 - 2.1e-06 27.5 0.0 3.5e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain HCO3_cotransp PF00955.21 EMC84250.1 - 3e-238 791.7 10.2 1.3e-237 789.7 10.2 1.8 1 1 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 EMC84250.1 - 1.6e-105 352.7 0.0 2.7e-105 352.0 0.0 1.4 1 0 0 1 1 1 1 Band 3 cytoplasmic domain DPPIV_N PF00930.21 EMC84251.1 - 1.4e-104 349.7 7.9 2.1e-104 349.1 7.9 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EMC84251.1 - 4.1e-55 186.5 2.6 7.4e-55 185.7 2.6 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DPPIV_rep PF18811.1 EMC84251.1 - 4.7e-07 29.5 11.1 1.5e-06 27.9 11.1 2.0 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) low complexity region DLH PF01738.18 EMC84251.1 - 1.2e-05 25.0 0.0 3e-05 23.7 0.0 1.5 1 1 0 1 1 1 1 Dienelactone hydrolase family LIP PF03583.14 EMC84251.1 - 0.00016 21.1 0.1 0.00038 19.9 0.1 1.5 1 0 0 1 1 1 1 Secretory lipase Abhydrolase_6 PF12697.7 EMC84251.1 - 0.0016 19.1 0.0 0.013 16.2 0.0 1.9 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EMC84251.1 - 0.0017 18.2 2.5 0.024 14.4 0.9 2.3 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EMC84251.1 - 0.006 15.9 0.4 0.41 9.9 0.1 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 EMC84251.1 - 0.026 14.1 3.2 0.15 11.6 0.7 2.2 1 1 1 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) zf-RanBP PF00641.18 EMC84251.1 - 0.061 12.7 0.2 0.19 11.1 0.2 1.9 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others Hormone_2 PF00123.20 EMC84252.1 - 3.4e-45 151.6 3.5 2e-14 53.1 0.4 3.2 3 0 0 3 3 3 3 Peptide hormone Lipoprotein_10 PF03202.13 EMC84252.1 - 1.6e-05 25.4 3.2 0.21 12.0 0.1 3.6 3 1 1 4 4 4 2 Putative mycoplasma lipoprotein, C-terminal region Sa_NUDIX PF18167.1 EMC84252.1 - 0.063 13.1 0.9 8.1 6.2 0.2 2.4 2 1 0 2 2 2 0 SMODS-associated NUDIX domain DPPIV_N PF00930.21 EMC84253.1 - 1.2e-96 323.6 8.1 1.7e-96 323.1 8.1 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EMC84253.1 - 3.9e-57 193.1 1.1 6.3e-57 192.5 1.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DPPIV_rep PF18811.1 EMC84253.1 - 1.4e-07 31.2 0.1 3e-07 30.2 0.1 1.6 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) low complexity region Esterase_phd PF10503.9 EMC84253.1 - 0.00012 21.6 0.0 0.00019 21.0 0.0 1.2 1 0 0 1 1 1 1 Esterase PHB depolymerase LIP PF03583.14 EMC84253.1 - 0.00041 19.8 0.2 0.00093 18.6 0.2 1.5 1 0 0 1 1 1 1 Secretory lipase DLH PF01738.18 EMC84253.1 - 0.001 18.6 0.1 0.0041 16.7 0.1 1.8 1 1 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S15 PF02129.18 EMC84253.1 - 0.0011 18.6 3.7 0.0029 17.2 0.5 2.3 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 EMC84253.1 - 0.0037 17.9 0.0 0.0088 16.7 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EMC84253.1 - 0.004 17.0 1.0 0.57 9.9 0.4 2.3 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase PAF-AH_p_II PF03403.13 EMC84253.1 - 0.0076 14.8 0.0 0.6 8.6 0.0 2.7 3 0 0 3 3 3 1 Platelet-activating factor acetylhydrolase, isoform II Hydrolase_4 PF12146.8 EMC84253.1 - 0.014 14.7 0.3 5 6.3 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 FSH1 PF03959.13 EMC84253.1 - 0.024 14.3 0.0 0.053 13.2 0.0 1.6 1 0 0 1 1 1 0 Serine hydrolase (FSH1) AXE1 PF05448.12 EMC84253.1 - 0.032 12.9 0.0 0.092 11.4 0.0 1.6 1 1 1 2 2 2 0 Acetyl xylan esterase (AXE1) Prot_inhib_II PF02428.15 EMC84253.1 - 0.095 13.2 1.6 0.19 12.2 1.6 1.5 1 0 0 1 1 1 0 Potato type II proteinase inhibitor family Ion_trans PF00520.31 EMC84254.1 - 2.2e-37 128.6 4.9 3.1e-37 128.1 4.9 1.2 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.29 EMC84254.1 - 1.6e-12 47.4 0.0 2.9e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 EMC84254.1 - 1.1e-11 44.5 0.0 1.1e-11 44.5 0.0 2.0 2 0 0 2 2 2 1 Ion channel AAA PF00004.29 EMC84255.1 - 1.5e-24 86.9 0.0 2.4e-24 86.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EMC84255.1 - 4.5e-07 29.8 0.0 1e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_5 PF07728.14 EMC84255.1 - 5.6e-05 23.2 0.0 0.00014 21.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 EMC84255.1 - 6.9e-05 22.6 0.0 0.00015 21.5 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EMC84255.1 - 0.0032 17.9 0.0 0.0087 16.5 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 EMC84255.1 - 0.02 14.6 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EMC84255.1 - 0.036 14.3 0.1 0.07 13.4 0.1 1.5 1 1 0 1 1 1 0 AAA domain TIP49 PF06068.13 EMC84255.1 - 0.14 11.3 0.1 0.28 10.3 0.0 1.4 2 0 0 2 2 2 0 TIP49 P-loop domain TRSP PF12500.8 EMC84255.1 - 0.16 11.9 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 TRSP domain C terminus to PRTase_2 BPS PF08947.10 EMC84256.1 - 4.3e-29 100.1 0.5 1.3e-28 98.6 0.5 1.8 1 0 0 1 1 1 1 BPS (Between PH and SH2) SH2 PF00017.24 EMC84256.1 - 1e-16 60.8 0.1 2.3e-16 59.6 0.1 1.6 1 0 0 1 1 1 1 SH2 domain RA PF00788.23 EMC84256.1 - 1.4e-13 51.3 0.1 5.7e-13 49.3 0.1 2.1 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain PH PF00169.29 EMC84256.1 - 2.9e-11 43.8 0.2 1e-10 42.1 0.1 2.0 2 0 0 2 2 2 1 PH domain PH_9 PF15410.6 EMC84256.1 - 0.11 12.9 0.2 0.34 11.3 0.0 1.8 2 0 0 2 2 2 0 Pleckstrin homology domain PH_11 PF15413.6 EMC84256.1 - 0.15 12.5 1.2 0.47 10.9 1.2 2.0 1 1 0 1 1 1 0 Pleckstrin homology domain Cobl PF09469.10 EMC84257.1 - 2.8e-43 146.1 0.6 8.2e-43 144.6 0.6 1.8 1 0 0 1 1 1 1 Cordon-bleu ubiquitin-like domain RBD PF02196.15 EMC84257.1 - 5.3e-07 29.6 0.2 0.047 13.8 0.1 2.5 2 0 0 2 2 2 2 Raf-like Ras-binding domain TUG-UBL1 PF11470.8 EMC84257.1 - 0.066 13.5 0.3 0.44 10.8 0.1 2.4 2 0 0 2 2 2 0 TUG ubiquitin-like domain YukD PF08817.10 EMC84257.1 - 0.17 12.6 0.1 2.8 8.7 0.0 2.6 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukD Aa_trans PF01490.18 EMC84258.1 - 1.1e-64 218.7 31.0 1.3e-64 218.5 31.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EMC84258.1 - 5.2e-06 25.8 15.2 5.2e-06 25.8 15.2 2.1 1 1 0 2 2 2 1 Tryptophan/tyrosine permease family Neurensin PF14927.6 EMC84258.1 - 0.16 11.7 2.7 0.65 9.7 0.0 2.9 3 0 0 3 3 3 0 Neurensin JSRP PF15312.6 EMC84258.1 - 3.4 7.6 4.5 0.62 10.0 0.3 1.9 2 0 0 2 2 2 0 Junctional sarcoplasmic reticulum protein CSRNP_N PF16019.5 EMC84259.1 - 3.5e-104 347.5 7.4 3.5e-104 347.5 7.4 2.2 2 0 0 2 2 2 1 Cysteine/serine-rich nuclear protein N-terminus Nop25 PF09805.9 EMC84259.1 - 0.014 15.8 6.4 0.78 10.2 0.1 2.6 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) GOLD_2 PF13897.6 EMC84259.1 - 2.4 8.7 5.6 0.6 10.6 1.8 2.0 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking Nop14 PF04147.12 EMC84259.1 - 3.1 5.9 18.2 0.064 11.5 7.9 2.1 2 0 0 2 2 2 0 Nop14-like family BUD22 PF09073.10 EMC84259.1 - 4.7 6.5 15.5 0.88 8.8 5.7 2.2 2 0 0 2 2 2 0 BUD22 Glycos_transf_2 PF00535.26 EMC84260.1 - 1.2e-34 119.6 0.0 2.1e-34 118.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 EMC84260.1 - 2e-25 89.5 0.5 3.2e-25 88.8 0.5 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 EMC84260.1 - 5.2e-09 35.6 0.0 2.9e-08 33.2 0.1 2.0 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_3 PF13641.6 EMC84260.1 - 1.3e-05 25.2 0.0 2.7e-05 24.2 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EMC84260.1 - 0.00035 20.1 0.0 0.1 12.0 0.0 2.2 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Wzy_C PF04932.15 EMC84260.1 - 0.17 11.5 0.0 0.32 10.6 0.0 1.4 1 0 0 1 1 1 0 O-Antigen ligase TPR_19 PF14559.6 EMC84261.1 - 2.5e-48 162.5 65.3 4e-06 27.2 0.4 17.2 12 5 6 18 18 17 10 Tetratricopeptide repeat TPR_2 PF07719.17 EMC84261.1 - 1.3e-44 146.7 75.1 9.9e-06 25.3 0.0 21.7 23 0 0 23 23 22 11 Tetratricopeptide repeat TPR_14 PF13428.6 EMC84261.1 - 1.8e-35 118.5 52.1 3.3e-05 24.3 0.1 21.2 15 5 8 24 24 22 7 Tetratricopeptide repeat TPR_1 PF00515.28 EMC84261.1 - 8.9e-34 113.9 62.6 1.9e-05 24.3 0.1 18.6 20 0 0 20 20 19 10 Tetratricopeptide repeat TPR_16 PF13432.6 EMC84261.1 - 7.4e-30 103.3 40.1 2.4e-06 28.1 0.1 16.7 16 4 3 19 19 18 7 Tetratricopeptide repeat TPR_8 PF13181.6 EMC84261.1 - 8.8e-28 94.2 54.9 0.00016 21.6 0.0 16.7 17 0 0 17 17 16 8 Tetratricopeptide repeat TPR_7 PF13176.6 EMC84261.1 - 1.5e-21 74.8 34.2 2.5e-05 24.0 0.0 14.6 15 2 2 17 17 15 5 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC84261.1 - 6.4e-20 71.2 59.6 0.00039 20.6 0.2 12.9 9 5 5 14 14 14 7 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EMC84261.1 - 2.3e-19 68.8 32.3 4.3e-05 23.1 0.2 12.5 12 2 2 14 14 14 6 TPR repeat TPR_12 PF13424.6 EMC84261.1 - 4.1e-19 68.6 58.6 0.00069 19.9 0.3 15.7 15 4 2 17 17 15 6 Tetratricopeptide repeat TPR_17 PF13431.6 EMC84261.1 - 1.6e-12 46.8 30.5 0.0051 17.1 0.4 14.1 18 0 0 18 18 12 2 Tetratricopeptide repeat TPR_6 PF13174.6 EMC84261.1 - 1.4e-11 44.2 72.9 0.027 15.1 0.0 19.5 24 1 0 24 24 17 4 Tetratricopeptide repeat TPR_9 PF13371.6 EMC84261.1 - 1.9e-08 34.3 13.2 0.17 12.0 0.0 7.9 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_15 PF13429.6 EMC84261.1 - 7.5e-05 22.1 43.3 0.0029 16.8 1.3 8.5 4 2 3 9 9 9 3 Tetratricopeptide repeat TPR_10 PF13374.6 EMC84261.1 - 0.00019 21.2 38.2 9.3 6.3 0.2 12.5 15 0 0 15 15 12 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMC84261.1 - 0.00045 20.2 36.8 0.74 9.9 0.2 11.3 12 0 0 12 12 12 2 Fis1 C-terminal tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EMC84261.1 - 0.00087 19.8 22.3 0.05 14.1 0.8 7.4 6 2 1 8 8 6 2 Alkyl sulfatase dimerisation DUF2225 PF09986.9 EMC84261.1 - 0.0028 17.4 29.3 0.0051 16.6 1.0 7.4 7 3 0 7 7 7 2 Uncharacterized protein conserved in bacteria (DUF2225) TPR_20 PF14561.6 EMC84261.1 - 0.0069 16.7 43.2 2.9 8.3 0.1 11.8 8 3 4 12 12 12 2 Tetratricopeptide repeat DUF3856 PF12968.7 EMC84261.1 - 0.013 15.6 2.1 6.9 6.7 0.1 5.3 4 2 1 5 5 4 0 Domain of Unknown Function (DUF3856) HrpB1_HrpK PF09613.10 EMC84261.1 - 0.025 14.2 21.7 0.32 10.7 0.1 8.5 8 1 0 8 8 8 0 Bacterial type III secretion protein (HrpB1_HrpK) MIT PF04212.18 EMC84261.1 - 0.14 12.2 33.0 2.4 8.3 0.4 10.5 10 1 0 10 10 10 0 MIT (microtubule interacting and transport) domain S-AdoMet_synt_M PF02772.16 EMC84261.1 - 0.25 11.6 1.4 0.8 10.0 1.4 1.8 1 0 0 1 1 1 0 S-adenosylmethionine synthetase, central domain SNAP PF14938.6 EMC84261.1 - 0.26 10.7 40.8 0.36 10.2 3.5 7.6 4 2 1 6 6 6 0 Soluble NSF attachment protein, SNAP DUF4363 PF14276.6 EMC84261.1 - 0.31 11.2 3.9 0.97 9.6 0.1 4.0 4 0 0 4 4 3 0 Domain of unknown function (DUF4363) SPOB_a PF14689.6 EMC84261.1 - 1.6 8.5 0.0 1.6 8.5 0.0 6.1 9 0 0 9 9 8 0 Sensor_kinase_SpoOB-type, alpha-helical domain Sel1 PF08238.12 EMC84261.1 - 4 8.3 18.5 22 5.9 0.1 7.9 9 0 0 9 9 6 0 Sel1 repeat Ion_trans PF00520.31 EMC84262.1 - 2.9e-67 226.5 32.1 3.4e-54 183.7 22.9 2.1 2 0 0 2 2 2 2 Ion transport protein GPHH PF16905.5 EMC84262.1 - 2e-06 27.4 0.0 3.7e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.12 EMC84262.1 - 9.1e-06 24.6 26.4 6.5e-05 21.8 2.4 3.3 2 1 1 3 3 3 2 Polycystin cation channel IQ PF00612.27 EMC84262.1 - 0.0011 18.5 1.6 0.0029 17.3 1.6 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif Ion_trans PF00520.31 EMC84263.1 - 4.9e-156 517.2 65.1 9e-78 260.9 17.4 3.3 3 0 0 3 3 3 3 Ion transport protein Na_trans_cytopl PF11933.8 EMC84263.1 - 1.7e-69 233.9 1.8 3.6e-69 232.8 1.8 1.5 1 0 0 1 1 1 1 Cytoplasmic domain of voltage-gated Na+ ion channel Na_trans_assoc PF06512.13 EMC84263.1 - 8.9e-52 176.3 4.6 8.9e-52 176.3 4.6 2.3 2 1 0 2 2 2 1 Sodium ion transport-associated ATP-synt_B PF00430.18 EMC84263.1 - 0.023 14.8 8.9 0.079 13.0 8.9 2.0 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) Tmemb_9 PF05434.11 EMC84263.1 - 0.061 13.2 3.7 3.1 7.7 0.1 2.7 2 0 0 2 2 2 0 TMEM9 UPF0242 PF06785.11 EMC84263.1 - 0.11 12.6 1.1 0.39 10.8 1.1 1.9 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus CytochromB561_N PF09786.9 EMC84263.1 - 0.11 11.5 0.1 0.24 10.3 0.1 1.5 1 0 0 1 1 1 0 Cytochrome B561, N terminal Neur_chan_memb PF02932.16 EMC84263.1 - 1.5 8.8 7.5 1.2 9.2 0.0 3.2 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region PKD_channel PF08016.12 EMC84263.1 - 4.4 5.9 52.0 0.017 13.8 10.2 5.8 4 2 2 6 6 6 0 Polycystin cation channel DUF4407 PF14362.6 EMC84263.1 - 8.4 5.6 7.7 20 4.4 7.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Galactosyl_T PF01762.21 EMC84264.1 - 1e-60 204.9 0.0 1.3e-60 204.6 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Pkinase PF00069.25 EMC84265.1 - 1e-60 205.3 0.0 1.4e-60 204.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC84265.1 - 1.8e-44 152.0 0.0 2.7e-44 151.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.8 EMC84265.1 - 3.4e-22 78.4 0.1 9e-22 77.1 0.1 1.8 1 0 0 1 1 1 1 Oxidative-stress-responsive kinase 1 C-terminal domain Kinase-like PF14531.6 EMC84265.1 - 0.0005 19.5 0.0 0.00078 18.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMC84265.1 - 0.00068 18.5 0.0 0.0022 16.8 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EMC84265.1 - 0.076 12.9 0.0 0.63 9.9 0.0 2.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 EMC84265.1 - 0.084 12.2 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EMC84265.1 - 0.094 11.6 0.0 0.19 10.6 0.0 1.6 1 1 0 1 1 1 0 Haspin like kinase domain TRAM_LAG1_CLN8 PF03798.16 EMC84266.1 - 7.6e-40 136.8 24.3 9.6e-40 136.4 24.3 1.1 1 0 0 1 1 1 1 TLC domain Homeodomain PF00046.29 EMC84266.1 - 1.5e-06 28.0 0.6 2.6e-06 27.2 0.6 1.4 1 0 0 1 1 1 1 Homeodomain Spindle_Spc25 PF08234.12 EMC84267.1 - 2.7e-24 85.2 0.7 7.1e-24 83.8 0.7 1.8 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 Spc7 PF08317.11 EMC84267.1 - 3.2e-05 23.0 16.7 4.2e-05 22.6 16.7 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF3584 PF12128.8 EMC84267.1 - 0.0012 16.5 12.2 0.0013 16.3 12.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) ATP-synt_F6 PF05511.11 EMC84267.1 - 0.009 16.4 3.6 0.91 10.0 0.6 2.7 2 1 1 3 3 3 1 Mitochondrial ATP synthase coupling factor 6 Atg14 PF10186.9 EMC84267.1 - 0.022 13.9 15.0 0.028 13.5 15.0 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Exonuc_VII_L PF02601.15 EMC84267.1 - 0.025 14.2 4.5 0.03 13.9 4.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Tox-ODYAM1 PF15642.6 EMC84267.1 - 0.061 12.3 8.3 0.083 11.9 8.3 1.3 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus UPF0242 PF06785.11 EMC84267.1 - 0.089 12.9 17.2 0.074 13.2 16.2 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Carbam_trans_N PF02543.15 EMC84267.1 - 0.11 12.1 0.7 0.15 11.7 0.7 1.2 1 0 0 1 1 1 0 Carbamoyltransferase N-terminus FlgN PF05130.12 EMC84267.1 - 0.33 11.4 9.9 0.58 10.7 9.9 1.3 1 0 0 1 1 1 0 FlgN protein GldM_N PF12081.8 EMC84267.1 - 0.39 10.8 10.1 0.17 12.0 6.6 2.0 1 1 2 3 3 3 0 GldM N-terminal domain TMPIT PF07851.13 EMC84267.1 - 0.48 9.6 11.1 0.71 9.1 11.1 1.2 1 0 0 1 1 1 0 TMPIT-like protein DHR10 PF18595.1 EMC84267.1 - 0.52 10.4 17.2 0.47 10.5 15.4 1.9 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain SlyX PF04102.12 EMC84267.1 - 0.69 10.6 4.5 2.9 8.6 4.3 2.2 1 1 0 1 1 1 0 SlyX FapA PF03961.13 EMC84267.1 - 0.72 8.4 13.2 0.91 8.1 13.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A LMBR1 PF04791.16 EMC84267.1 - 1.7 7.5 10.2 2 7.2 10.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein CENP-H PF05837.12 EMC84267.1 - 1.9 8.9 16.8 0.43 11.0 12.5 1.9 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF1664 PF07889.12 EMC84267.1 - 2.4 8.2 10.4 7.6 6.6 2.7 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 EMC84267.1 - 4.8 7.4 13.6 3.1 8.0 10.4 2.0 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family YabA PF06156.13 EMC84267.1 - 5.6 7.7 13.1 3.8 8.2 10.1 2.1 1 1 1 2 2 2 0 Initiation control protein YabA Dynamin_N PF00350.23 EMC84267.1 - 6.8 6.7 11.3 60 3.6 11.2 2.2 1 1 0 1 1 1 0 Dynamin family PAP2 PF01569.21 EMC84268.1 - 5.6e-17 61.8 7.9 1.4e-16 60.5 7.9 1.7 1 0 0 1 1 1 1 PAP2 superfamily SpoVAB PF13782.6 EMC84268.1 - 0.15 12.4 4.1 0.2 12.0 2.7 1.9 2 0 0 2 2 2 0 Stage V sporulation protein AB ABC_membrane PF00664.23 EMC84269.1 - 3e-121 404.3 25.4 2e-73 247.4 3.2 3.1 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 EMC84269.1 - 9.4e-74 246.4 0.6 1.7e-35 122.5 0.1 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EMC84269.1 - 4.8e-13 49.1 0.5 3.8e-06 26.5 0.5 3.0 2 2 2 4 4 4 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EMC84269.1 - 7.5e-10 39.0 0.0 0.00068 19.6 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EMC84269.1 - 1e-07 32.5 0.2 0.0076 16.7 0.1 2.9 2 0 0 2 2 2 2 AAA ATPase domain Zeta_toxin PF06414.12 EMC84269.1 - 4.9e-06 25.9 0.2 0.004 16.4 0.0 2.7 3 0 0 3 3 3 2 Zeta toxin AAA_22 PF13401.6 EMC84269.1 - 9.6e-06 25.9 0.1 0.079 13.2 0.1 3.1 2 1 0 2 2 2 2 AAA domain AAA_15 PF13175.6 EMC84269.1 - 9.7e-06 25.5 0.0 0.074 12.7 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EMC84269.1 - 4.6e-05 23.1 0.4 0.086 12.6 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_30 PF13604.6 EMC84269.1 - 0.00013 21.8 0.4 0.94 9.2 0.0 3.1 2 1 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EMC84269.1 - 0.00033 21.0 0.0 9.8 6.4 0.0 3.6 3 0 0 3 3 3 0 AAA domain ABC_ATPase PF09818.9 EMC84269.1 - 0.00045 19.1 0.3 0.78 8.5 0.0 2.7 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_7 PF12775.7 EMC84269.1 - 0.00093 18.8 0.0 0.51 9.8 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region G-alpha PF00503.20 EMC84269.1 - 0.0012 18.1 0.0 1.6 7.8 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit Rad17 PF03215.15 EMC84269.1 - 0.0046 16.9 0.0 0.24 11.3 0.0 2.8 2 1 1 3 3 3 1 Rad17 P-loop domain AAA_33 PF13671.6 EMC84269.1 - 0.0079 16.4 0.0 7.5 6.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.17 EMC84269.1 - 0.0093 16.1 0.1 5.1 7.1 0.0 2.6 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_21 PF13304.6 EMC84269.1 - 0.0098 15.7 0.0 0.25 11.1 0.0 2.8 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system SRP54 PF00448.22 EMC84269.1 - 0.034 13.8 0.0 4.5 6.8 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain SbcCD_C PF13558.6 EMC84269.1 - 0.038 14.2 3.3 2.5 8.4 0.2 3.5 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.6 EMC84269.1 - 0.042 13.4 2.4 3 7.4 0.0 3.6 4 0 0 4 4 4 0 AAA domain RNA_helicase PF00910.22 EMC84269.1 - 0.059 13.8 0.0 11 6.5 0.0 3.2 3 0 0 3 3 2 0 RNA helicase APS_kinase PF01583.20 EMC84269.1 - 0.071 13.0 0.0 3.3 7.6 0.0 2.6 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_10 PF12846.7 EMC84269.1 - 0.11 11.4 0.1 13 4.6 0.0 2.4 2 0 0 2 2 2 0 AAA-like domain DUF815 PF05673.13 EMC84269.1 - 0.12 11.5 0.0 17 4.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) MMR_HSR1 PF01926.23 EMC84269.1 - 0.16 12.1 0.0 15 5.7 0.0 2.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_23 PF13476.6 EMC84269.1 - 0.21 12.1 0.3 4.1 7.8 0.1 2.4 2 0 0 2 2 2 0 AAA domain adh_short PF00106.25 EMC84271.1 - 6.4e-23 81.2 0.0 8.8e-23 80.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC84271.1 - 8.4e-11 41.9 0.0 1.2e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC84271.1 - 0.015 15.2 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 KR domain Ldl_recept_a PF00057.18 EMC84272.1 - 0 1101.3 673.7 3e-12 46.5 9.2 38.3 38 1 0 38 38 38 36 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 EMC84272.1 - 1.4e-203 659.2 91.8 5.5e-11 42.8 0.0 37.8 38 0 0 38 38 38 28 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 EMC84272.1 - 5.3e-64 212.2 343.7 5.2e-10 39.4 5.8 24.8 23 1 0 23 23 23 16 Coagulation Factor Xa inhibitory site DUF5050 PF16472.5 EMC84272.1 - 1.3e-34 119.8 0.2 1.4e-07 31.1 0.0 10.5 8 3 0 9 9 9 9 Domain of unknown function (DUF5050) cEGF PF12662.7 EMC84272.1 - 3.5e-29 100.4 148.5 2.9e-09 36.7 2.0 19.4 19 0 0 19 19 19 10 Complement Clr-like EGF-like SGL PF08450.12 EMC84272.1 - 2.6e-17 63.2 27.4 0.028 14.0 1.0 15.3 9 7 4 15 15 15 6 SMP-30/Gluconolactonase/LRE-like region EGF_CA PF07645.15 EMC84272.1 - 5.3e-12 45.7 43.5 3.7e-08 33.4 6.9 35.4 28 12 14 43 43 43 7 Calcium-binding EGF domain VWA PF00092.28 EMC84273.1 - 6e-68 228.5 1.0 3.2e-40 138.2 0.2 2.1 2 0 0 2 2 2 2 von Willebrand factor type A domain Collagen PF01391.18 EMC84273.1 - 6.2e-65 214.9 274.9 2.9e-09 36.6 22.9 11.6 2 2 5 7 7 7 5 Collagen triple helix repeat (20 copies) VWA_2 PF13519.6 EMC84273.1 - 5e-29 101.1 0.1 3e-19 69.6 0.1 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain Kunitz_BPTI PF00014.23 EMC84273.1 - 5.7e-19 68.1 6.9 1.2e-18 67.1 6.9 1.6 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain VWA_3 PF13768.6 EMC84273.1 - 2.1e-06 27.8 0.0 0.0002 21.4 0.0 2.8 3 0 0 3 3 3 1 von Willebrand factor type A domain BBL5 PF07289.11 EMC84274.1 - 1.9e-157 523.5 0.0 2.2e-157 523.3 0.0 1.0 1 0 0 1 1 1 1 Bardet-Biedl syndrome 5 protein Vps36_ESCRT-II PF11605.8 EMC84274.1 - 6.1e-05 23.1 0.0 0.12 12.6 0.0 2.4 2 0 0 2 2 2 2 Vacuolar protein sorting protein 36 Vps36 bPH_3 PF14470.6 EMC84274.1 - 0.00015 22.1 0.0 0.0044 17.3 0.0 2.3 2 0 0 2 2 2 1 Bacterial PH domain GRAM PF02893.20 EMC84274.1 - 0.00026 20.8 0.1 0.085 12.7 0.0 2.5 2 0 0 2 2 2 2 GRAM domain PH_TFIIH PF08567.11 EMC84274.1 - 0.00078 19.7 0.0 0.098 13.0 0.0 2.5 2 0 0 2 2 2 1 TFIIH p62 subunit, N-terminal domain Voldacs PF03517.13 EMC84274.1 - 0.014 15.6 1.6 1.1 9.4 0.1 3.0 2 1 0 3 3 3 0 Regulator of volume decrease after cellular swelling Kelch_1 PF01344.25 EMC84275.1 - 1.7e-43 145.9 0.0 5.7e-10 38.6 0.0 5.5 6 0 0 6 6 6 5 Kelch motif BACK PF07707.15 EMC84275.1 - 5.1e-31 106.8 0.7 1.4e-30 105.4 0.3 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 EMC84275.1 - 1.6e-28 99.1 0.5 3.5e-28 98.0 0.5 1.6 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.6 EMC84275.1 - 2.2e-28 97.5 0.0 2.3e-08 34.0 0.0 5.6 2 1 3 5 5 5 5 Kelch motif Kelch_4 PF13418.6 EMC84275.1 - 8.2e-20 70.6 0.0 1.1e-06 28.6 0.0 5.1 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_3 PF13415.6 EMC84275.1 - 1.4e-18 66.7 0.0 0.013 15.7 0.0 5.2 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_2 PF07646.15 EMC84275.1 - 5e-17 61.1 0.1 0.19 11.7 0.0 5.5 4 1 1 5 5 5 5 Kelch motif Kelch_5 PF13854.6 EMC84275.1 - 4.5e-13 48.9 0.0 0.28 11.2 0.0 5.4 5 0 0 5 5 5 4 Kelch motif DUF3342 PF11822.8 EMC84275.1 - 0.0016 18.6 0.3 0.039 14.2 0.1 2.7 1 1 2 3 3 3 1 Domain of unknown function (DUF3342) FAST_2 PF08368.12 EMC84276.1 - 5.2e-31 107.3 0.9 3.9e-29 101.3 0.0 3.0 2 0 0 2 2 2 1 FAST kinase-like protein, subdomain 2 FAST_1 PF06743.15 EMC84276.1 - 9.4e-21 73.6 17.0 1.4e-18 66.6 2.6 5.1 5 0 0 5 5 5 2 FAST kinase-like protein, subdomain 1 RAP PF08373.10 EMC84276.1 - 1.2e-14 54.2 0.0 4.4e-14 52.3 0.0 2.1 1 0 0 1 1 1 1 RAP domain Pro_isomerase PF00160.21 EMC84277.1 - 5.3e-48 163.3 0.2 5.3e-48 163.3 0.2 2.6 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SR-25 PF10500.9 EMC84277.1 - 3.3e-07 30.2 41.1 3.3e-07 30.2 41.1 5.7 2 1 4 6 6 6 1 Nuclear RNA-splicing-associated protein TPH PF13868.6 EMC84278.1 - 9.5e-19 67.1 126.6 9.5e-19 67.1 126.6 2.1 2 0 0 2 2 2 1 Trichohyalin-plectin-homology domain Put_Phosphatase PF06888.12 EMC84279.1 - 3.9e-91 304.6 0.0 4.4e-91 304.4 0.0 1.0 1 0 0 1 1 1 1 Putative Phosphatase HAD PF12710.7 EMC84279.1 - 9.4e-10 39.2 0.0 4.9e-09 36.8 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EMC84279.1 - 0.015 15.4 0.9 2 8.4 0.9 3.0 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EMC84279.1 - 0.21 11.8 0.0 4.2 7.6 0.0 2.3 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Kelch_1 PF01344.25 EMC84280.1 - 5.5e-49 163.5 33.4 8.2e-13 47.7 0.4 7.2 7 1 0 7 7 7 6 Kelch motif Kelch_6 PF13964.6 EMC84280.1 - 1.1e-35 120.8 11.2 3.1e-09 36.8 0.0 6.4 3 2 3 6 6 6 6 Kelch motif BTB PF00651.31 EMC84280.1 - 6.1e-31 106.9 1.3 9.5e-31 106.3 1.3 1.3 1 0 0 1 1 1 1 BTB/POZ domain Kelch_4 PF13418.6 EMC84280.1 - 2.6e-25 88.2 6.1 1.6e-05 24.8 0.0 6.6 5 1 1 6 6 6 5 Galactose oxidase, central domain BACK PF07707.15 EMC84280.1 - 3.1e-25 88.3 3.0 3.1e-25 88.3 3.0 2.4 3 0 0 3 3 3 1 BTB And C-terminal Kelch Kelch_2 PF07646.15 EMC84280.1 - 2.5e-23 81.1 16.2 1.7e-05 24.6 0.0 7.2 6 2 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 EMC84280.1 - 4.8e-14 52.2 10.1 0.00035 20.8 0.0 5.6 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC84280.1 - 1e-09 38.1 21.2 0.0036 17.2 0.3 6.6 7 0 0 7 7 7 4 Kelch motif DUF3342 PF11822.8 EMC84280.1 - 0.00059 20.0 0.1 0.0019 18.4 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Skp1_POZ PF03931.15 EMC84280.1 - 0.036 14.2 0.0 0.12 12.6 0.0 1.9 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain RRM_3 PF08777.11 EMC84281.1 - 5.2e-28 97.1 2.1 5.2e-28 97.1 2.1 2.8 2 1 0 2 2 2 1 RNA binding motif La PF05383.17 EMC84281.1 - 6.4e-22 77.4 0.1 1.2e-21 76.5 0.1 1.5 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 EMC84281.1 - 6.7e-15 54.7 0.2 2.2e-09 37.0 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MTS PF05175.14 EMC84282.1 - 3.3e-14 52.8 0.1 4.7e-14 52.3 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EMC84282.1 - 2.2e-11 43.7 0.2 3.6e-11 43.0 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EMC84282.1 - 6.7e-10 39.0 0.1 9.1e-10 38.5 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 EMC84282.1 - 6.7e-09 35.6 0.0 9.1e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 EMC84282.1 - 1.6e-08 35.2 0.3 3.3e-08 34.1 0.1 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_15 PF09445.10 EMC84282.1 - 2.5e-06 27.2 0.2 3.8e-06 26.6 0.2 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase UPF0020 PF01170.18 EMC84282.1 - 4.1e-05 23.4 0.4 0.00023 20.9 0.4 2.0 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_12 PF08242.12 EMC84282.1 - 0.0011 19.7 0.1 0.0024 18.6 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain FmrO PF07091.11 EMC84282.1 - 0.0058 16.2 0.1 0.01 15.4 0.1 1.4 1 0 0 1 1 1 1 Ribosomal RNA methyltransferase (FmrO) N6_Mtase PF02384.16 EMC84282.1 - 0.0074 15.6 0.3 0.027 13.8 0.2 1.9 1 1 0 1 1 1 1 N-6 DNA Methylase Methyltransf_18 PF12847.7 EMC84282.1 - 0.0077 16.2 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DNA_methylase PF00145.17 EMC84282.1 - 0.018 14.4 0.0 0.034 13.5 0.0 1.5 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase Methyltransf_9 PF08003.11 EMC84282.1 - 0.027 13.4 0.5 0.04 12.8 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1698) TehB PF03848.14 EMC84282.1 - 0.029 13.8 0.2 0.048 13.1 0.2 1.4 1 1 0 1 1 1 0 Tellurite resistance protein TehB N6-adenineMlase PF10237.9 EMC84282.1 - 0.034 13.9 0.1 0.049 13.4 0.1 1.2 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase Methyltransf_4 PF02390.17 EMC84282.1 - 0.04 13.4 0.0 0.051 13.0 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_16 PF10294.9 EMC84282.1 - 0.048 13.4 0.5 0.096 12.4 0.1 1.7 2 0 0 2 2 2 0 Lysine methyltransferase UPF0444 PF15475.6 EMC84282.1 - 0.1 12.9 0.0 0.2 12.0 0.0 1.4 2 0 0 2 2 1 0 Transmembrane protein C12orf23, UPF0444 Methyltr_RsmB-F PF01189.17 EMC84282.1 - 0.13 11.9 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F zf-RING_5 PF14634.6 EMC84283.1 - 0.0025 17.7 0.7 0.0025 17.7 0.7 3.3 3 0 0 3 3 3 1 zinc-RING finger domain CRAL_TRIO PF00650.20 EMC84283.1 - 0.0089 15.8 0.4 0.03 14.1 0.4 1.9 1 0 0 1 1 1 1 CRAL/TRIO domain zf-C3HC4 PF00097.25 EMC84283.1 - 0.015 15.2 0.5 0.015 15.2 0.5 3.6 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) FliD_N PF02465.18 EMC84283.1 - 7.8 7.3 6.3 5.8 7.7 1.6 2.6 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Myosin_head PF00063.21 EMC84284.1 - 2e-201 670.7 2.7 2.5e-201 670.5 2.7 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Pkinase PF00069.25 EMC84284.1 - 2.5e-57 194.2 0.0 4.2e-57 193.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC84284.1 - 2.5e-41 141.7 0.0 4.1e-41 141.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EMC84284.1 - 2.4e-06 27.6 0.0 0.047 13.6 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EMC84284.1 - 4e-06 25.9 0.0 7e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase IQ PF00612.27 EMC84284.1 - 0.00017 21.1 5.8 0.01 15.5 0.0 3.0 3 0 0 3 3 3 2 IQ calmodulin-binding motif Kinase-like PF14531.6 EMC84284.1 - 0.00022 20.6 0.0 0.00043 19.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like AAA_22 PF13401.6 EMC84284.1 - 0.021 15.1 0.0 0.071 13.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EMC84284.1 - 0.098 13.0 0.1 0.38 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.12 EMC84284.1 - 0.14 11.5 0.0 0.29 10.4 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin APH_6_hur PF04655.14 EMC84284.1 - 0.19 11.1 0.1 0.71 9.2 0.0 1.9 2 0 0 2 2 2 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase GRASP55_65 PF04495.14 EMC84285.1 - 6e-70 233.9 0.0 2.4e-54 183.4 0.0 2.2 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_6 PF17820.1 EMC84285.1 - 2.4e-08 33.7 0.0 0.0032 17.3 0.0 2.7 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 EMC84285.1 - 1.6e-06 28.3 0.0 0.044 14.1 0.0 2.4 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 EMC84285.1 - 0.13 12.6 0.0 32 5.0 0.0 2.5 2 0 0 2 2 2 0 PDZ domain Pkinase PF00069.25 EMC84286.1 - 5.7e-61 206.2 0.0 5.7e-61 206.2 0.0 1.9 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC84286.1 - 2.2e-34 119.0 0.0 4.9e-34 117.8 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Vir_act_alpha_C PF10400.9 EMC84286.1 - 3.6 8.3 16.9 2.4 8.9 3.5 3.7 3 1 0 3 3 3 0 Virulence activator alpha C-term Methyltransf_25 PF13649.6 EMC84287.1 - 3.1e-13 50.2 0.1 9.7e-13 48.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC84287.1 - 1e-12 48.2 0.0 2e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC84287.1 - 1.3e-11 45.1 0.0 3.5e-11 43.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC84287.1 - 2.3e-11 44.2 0.1 5.6e-11 42.9 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC84287.1 - 3.2e-06 27.0 0.0 6.7e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 EMC84287.1 - 0.0077 15.7 0.0 0.2 11.1 0.0 2.3 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain Methyltransf_24 PF13578.6 EMC84287.1 - 0.0096 16.9 0.0 0.032 15.3 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain NodS PF05401.11 EMC84287.1 - 0.014 15.0 0.0 0.054 13.1 0.0 1.8 2 0 0 2 2 2 0 Nodulation protein S (NodS) Methyltransf_28 PF02636.17 EMC84287.1 - 0.067 12.8 0.3 4 7.0 0.0 2.9 3 0 0 3 3 3 0 Putative S-adenosyl-L-methionine-dependent methyltransferase MTS PF05175.14 EMC84287.1 - 0.073 12.6 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Gal-bind_lectin PF00337.22 EMC84287.1 - 1.3 8.5 5.6 7.5 6.1 4.6 2.2 1 1 0 1 1 1 0 Galactoside-binding lectin DCAF17 PF15802.5 EMC84288.1 - 8.6e-222 737.0 0.2 9.7e-222 736.8 0.2 1.0 1 0 0 1 1 1 1 DDB1- and CUL4-associated factor 17 Dynein_IC2 PF11540.8 EMC84289.1 - 3.4e-15 55.7 0.6 7.2e-15 54.6 0.6 1.6 1 0 0 1 1 1 1 Cytoplasmic dynein 1 intermediate chain 2 WD40 PF00400.32 EMC84289.1 - 1.6e-07 31.9 10.3 0.096 13.6 0.3 7.1 7 0 0 7 7 7 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC84289.1 - 0.0011 19.2 0.0 0.028 14.7 0.0 3.2 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain MAT1 PF06391.13 EMC84289.1 - 0.15 11.9 15.8 1.7 8.4 7.5 2.3 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Mito_carr PF00153.27 EMC84290.1 - 2.9e-73 241.9 0.6 9.1e-26 89.6 0.1 3.5 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.32 EMC84290.1 - 8.1e-13 46.9 2.1 0.013 15.0 0.1 5.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EMC84290.1 - 6.2e-12 44.4 2.7 0.0078 16.1 0.1 6.0 5 0 0 5 5 5 3 EF-hand domain EF-hand_7 PF13499.6 EMC84290.1 - 1.3e-10 41.5 1.3 0.00095 19.6 0.0 4.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 EMC84290.1 - 1.4e-06 28.0 0.0 0.0024 17.7 0.0 4.2 4 0 0 4 4 4 1 EF-hand domain pair EF-hand_5 PF13202.6 EMC84290.1 - 9.4e-05 21.7 1.3 2.2 7.9 0.0 4.1 4 0 0 4 4 4 2 EF hand DUF4734 PF15881.5 EMC84290.1 - 0.14 12.4 1.2 0.34 11.1 0.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4734) Hat1_N PF10394.9 EMC84291.1 - 1.1e-46 159.0 0.8 2.2e-46 158.0 0.6 1.6 2 0 0 2 2 2 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 EMC84291.1 - 0.025 14.8 0.0 0.055 13.7 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family MOZ_SAS PF01853.18 EMC84291.1 - 0.042 13.5 0.1 0.089 12.4 0.1 1.5 1 0 0 1 1 1 0 MOZ/SAS family Acetyltransf_10 PF13673.7 EMC84291.1 - 0.043 13.8 0.0 0.15 12.0 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMC84291.1 - 0.05 14.0 0.0 0.13 12.7 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Peptidase_M24 PF00557.24 EMC84292.1 - 5.6e-56 189.5 0.0 6.9e-56 189.2 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Homeodomain PF00046.29 EMC84293.1 - 1.3e-20 73.0 3.2 2e-20 72.4 3.2 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC84293.1 - 0.0052 16.7 0.7 0.011 15.6 0.0 1.9 2 0 0 2 2 2 1 Homeobox KN domain Homez PF11569.8 EMC84293.1 - 0.071 12.6 0.1 0.13 11.7 0.1 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez YdaS_antitoxin PF15943.5 EMC84293.1 - 0.097 12.5 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT DLL_N PF12413.8 EMC84294.1 - 6.4e-18 65.8 13.1 1e-17 65.2 13.1 1.3 1 0 0 1 1 1 1 Homeobox protein distal-less-like N terminal Homeodomain PF00046.29 EMC84294.1 - 7.1e-11 41.8 0.5 9.6e-11 41.4 0.5 1.2 1 0 0 1 1 1 1 Homeodomain GP38 PF05268.11 EMC84294.1 - 0.012 15.3 4.6 0.015 15.0 4.6 1.0 1 0 0 1 1 1 0 Phage tail fibre adhesin Gp38 DmpG_comm PF07836.11 EMC84294.1 - 0.022 14.3 0.2 0.38 10.3 0.1 2.3 2 0 0 2 2 2 0 DmpG-like communication domain Integrin_alpha2 PF08441.12 EMC84295.1 - 1.3e-127 426.6 4.7 1.8e-127 426.1 4.7 1.2 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 EMC84295.1 - 1.9e-19 69.4 24.3 2.1e-09 37.4 6.7 4.3 4 0 0 4 4 4 3 FG-GAP repeat VCBS PF13517.6 EMC84295.1 - 1.5e-14 54.3 10.8 1.4e-10 41.6 2.7 3.1 1 1 2 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.20 EMC84295.1 - 9.4e-05 22.1 1.2 9.4e-05 22.1 1.2 2.5 2 0 0 2 2 2 1 Integrin alpha cytoplasmic region DUF4381 PF14316.6 EMC84295.1 - 0.23 11.7 0.1 0.41 10.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) BCDHK_Adom3 PF10436.9 EMC84296.1 - 7.9e-49 165.6 0.0 1.3e-48 164.9 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EMC84296.1 - 1.5e-14 54.4 0.0 3e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EMC84296.1 - 0.00057 19.7 0.0 0.001 18.9 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PDZ_5 PF17817.1 EMC84297.1 - 8.1e-18 64.5 3.3 8.1e-18 64.5 3.3 2.5 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 EMC84297.1 - 4.6e-14 52.5 1.9 1.3e-13 51.1 1.9 1.8 1 0 0 1 1 1 1 PDZ domain SAM_2 PF07647.17 EMC84297.1 - 5.2e-09 36.1 0.3 1.3e-08 34.9 0.3 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EMC84297.1 - 6.1e-08 33.0 2.3 9.2e-08 32.4 0.8 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PDZ_6 PF17820.1 EMC84297.1 - 1.3e-05 25.0 0.1 0.00014 21.6 0.1 2.6 2 0 0 2 2 2 1 PDZ domain SAM_PNT PF02198.16 EMC84297.1 - 0.00051 20.0 1.5 0.0014 18.5 1.5 1.7 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain PDZ_2 PF13180.6 EMC84297.1 - 0.0059 16.9 0.3 0.021 15.1 0.3 2.0 1 0 0 1 1 1 1 PDZ domain DUF2407_C PF13373.6 EMC84297.1 - 0.22 11.7 4.1 0.57 10.3 4.1 1.7 1 0 0 1 1 1 0 DUF2407 C-terminal domain SAM_3 PF18016.1 EMC84297.1 - 0.59 10.0 4.4 0.22 11.3 0.2 2.5 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) DUF1515 PF07439.11 EMC84297.1 - 0.67 10.0 2.7 1.1 9.3 0.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) Membr_traf_MHD PF10540.9 EMC84298.1 - 3.1e-56 189.7 1.1 9.2e-56 188.2 1.1 1.9 1 0 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 EMC84298.1 - 2.5e-43 146.6 4.2 5.3e-27 94.1 0.2 4.5 4 0 0 4 4 4 2 C2 domain DUF1041 PF06292.17 EMC84298.1 - 1.7e-36 124.8 2.1 4.7e-36 123.4 0.0 2.6 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1041) C1_1 PF00130.22 EMC84298.1 - 1.1e-10 41.2 5.7 2.5e-10 40.1 5.7 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PhoLip_ATPase_C PF16212.5 EMC84299.1 - 6.2e-83 278.4 30.4 6.2e-83 278.4 30.4 2.0 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 EMC84299.1 - 3.6e-12 47.0 0.1 2e-05 25.0 0.0 3.3 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EMC84299.1 - 9.1e-11 41.7 0.0 1.5e-09 37.8 0.0 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EMC84299.1 - 2.6e-06 27.1 0.0 9.2e-06 25.3 0.0 2.0 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EMC84299.1 - 0.00033 20.5 0.0 0.0012 18.6 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EMC84299.1 - 0.027 14.5 1.7 0.84 9.7 0.5 2.9 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase RUN PF02759.19 EMC84300.1 - 1.5e-18 67.0 0.2 3e-18 66.1 0.2 1.5 1 0 0 1 1 1 1 RUN domain SH3_9 PF14604.6 EMC84300.1 - 5.3e-10 39.0 0.0 2.4e-09 36.9 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EMC84300.1 - 2.8e-07 30.0 0.9 3.9e-07 29.6 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EMC84300.1 - 1.1e-06 28.2 0.0 2.7e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Y_phosphatase PF00102.27 EMC84301.1 - 6.2e-103 343.4 0.1 1.3e-84 283.4 0.2 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 EMC84301.1 - 5.2e-07 29.5 0.0 1.2e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC84301.1 - 0.0013 18.8 0.0 0.0024 17.9 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EMC84301.1 - 0.072 13.2 0.0 0.27 11.3 0.0 2.0 2 0 0 2 2 2 0 Inositol hexakisphosphate Y_phosphatase PF00102.27 EMC84302.1 - 1.8e-17 63.7 0.1 1.9e-17 63.6 0.1 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EMC84302.1 - 1.7e-05 24.6 0.1 2.2e-05 24.3 0.1 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain MdcE PF06833.11 EMC84302.1 - 0.16 11.5 0.0 0.16 11.4 0.0 1.1 1 0 0 1 1 1 0 Malonate decarboxylase gamma subunit (MdcE) Pkinase_Tyr PF07714.17 EMC84303.1 - 5.7e-38 130.7 0.0 7.1e-38 130.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC84303.1 - 8.6e-35 120.4 0.0 1.5e-34 119.6 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EMC84303.1 - 7.4e-05 21.7 0.0 0.0001 21.2 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EMC84303.1 - 0.0016 17.8 0.0 0.0038 16.6 0.0 1.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Spc7 PF08317.11 EMC84305.1 - 0.00018 20.5 3.7 0.00023 20.2 3.7 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein HemX PF04375.14 EMC84305.1 - 0.0017 17.7 3.6 0.0022 17.3 3.6 1.1 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase CENP-H PF05837.12 EMC84305.1 - 0.012 16.1 6.8 0.017 15.5 6.8 1.2 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Ly49 PF08391.10 EMC84305.1 - 0.013 15.9 0.6 0.057 13.8 0.6 1.9 1 1 0 1 1 1 0 Ly49-like protein, N-terminal region HMMR_N PF15905.5 EMC84305.1 - 0.029 13.8 3.7 0.04 13.4 3.7 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF2681 PF10883.8 EMC84305.1 - 0.042 14.3 2.3 0.48 10.9 0.1 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF2681) DUF4200 PF13863.6 EMC84305.1 - 0.075 13.4 3.3 0.13 12.7 3.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) DUF1664 PF07889.12 EMC84305.1 - 0.08 13.0 1.4 0.22 11.6 1.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.9 EMC84305.1 - 0.081 12.9 6.8 0.11 12.5 6.8 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CdvA PF18822.1 EMC84305.1 - 0.12 12.2 3.6 0.23 11.3 3.6 1.4 1 1 0 1 1 1 0 CdvA-like coiled-coil domain Snapin_Pallidin PF14712.6 EMC84305.1 - 0.16 12.4 3.3 12 6.4 1.3 2.2 1 1 1 2 2 2 0 Snapin/Pallidin FapA PF03961.13 EMC84305.1 - 0.18 10.4 0.3 0.23 10.0 0.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Val_tRNA-synt_C PF10458.9 EMC84305.1 - 0.24 11.7 0.3 0.24 11.7 0.3 2.3 2 1 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm SlyX PF04102.12 EMC84305.1 - 0.36 11.5 4.3 9.3 7.0 0.0 2.4 1 1 1 2 2 2 0 SlyX Prefoldin_2 PF01920.20 EMC84305.1 - 0.39 10.7 4.6 5.1 7.1 0.5 2.3 2 0 0 2 2 2 0 Prefoldin subunit Golgin_A5 PF09787.9 EMC84305.1 - 0.83 9.1 8.1 3.2 7.2 0.2 1.8 1 1 0 1 1 1 0 Golgin subfamily A member 5 OmpH PF03938.14 EMC84305.1 - 2.4 8.5 7.0 6.3 7.1 7.0 1.6 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) APG6_N PF17675.1 EMC84305.1 - 2.4 8.7 12.6 2.5 8.7 11.4 1.5 1 1 0 1 1 1 0 Apg6 coiled-coil region Phage_holin_3_6 PF07332.11 EMC84305.1 - 3.1 7.9 5.7 15 5.6 0.5 2.4 1 1 1 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III TMF_DNA_bd PF12329.8 EMC84305.1 - 4.2 7.4 11.2 2.8 8.0 1.8 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding HIP1_clath_bdg PF16515.5 EMC84305.1 - 9 7.0 11.4 14 6.4 8.1 2.1 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Spc7 PF08317.11 EMC84306.1 - 3.1e-05 23.0 2.5 3.9e-05 22.7 2.5 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein UPF0242 PF06785.11 EMC84306.1 - 0.00039 20.6 3.2 0.00062 19.9 3.2 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus CENP-F_leu_zip PF10473.9 EMC84306.1 - 0.00064 19.8 12.0 0.00083 19.4 12.0 1.1 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6_N PF17675.1 EMC84306.1 - 0.0013 19.3 10.8 0.0019 18.8 10.8 1.1 1 0 0 1 1 1 1 Apg6 coiled-coil region HemX PF04375.14 EMC84306.1 - 0.004 16.5 8.5 0.0053 16.1 8.5 1.1 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase DUF2681 PF10883.8 EMC84306.1 - 0.0058 17.0 6.9 0.45 10.9 0.1 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF2681) Ly49 PF08391.10 EMC84306.1 - 0.032 14.6 2.1 0.12 12.8 2.1 1.8 1 1 0 1 1 1 0 Ly49-like protein, N-terminal region HMMR_N PF15905.5 EMC84306.1 - 0.035 13.6 6.2 0.047 13.2 6.2 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Lectin_C PF00059.21 EMC84306.1 - 0.04 14.7 1.8 6 7.6 0.1 2.8 3 1 0 3 3 3 0 Lectin C-type domain GCP_N_terminal PF17681.1 EMC84306.1 - 0.051 13.2 0.7 0.07 12.7 0.7 1.1 1 0 0 1 1 1 0 Gamma tubulin complex component N-terminal ERM PF00769.19 EMC84306.1 - 0.07 12.9 9.5 0.097 12.5 9.5 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family HAP1_N PF04849.13 EMC84306.1 - 0.088 12.0 12.4 0.12 11.5 12.4 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region Exonuc_VII_L PF02601.15 EMC84306.1 - 0.17 11.4 1.8 0.23 11.0 1.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit ATG16 PF08614.11 EMC84306.1 - 0.23 11.7 14.5 0.32 11.2 14.5 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) FapA PF03961.13 EMC84306.1 - 0.4 9.2 1.2 0.51 8.9 1.2 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A CENP-H PF05837.12 EMC84306.1 - 0.42 11.0 11.7 0.61 10.5 11.7 1.2 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DegS PF05384.11 EMC84306.1 - 0.92 9.0 8.2 1.3 8.5 8.2 1.1 1 0 0 1 1 1 0 Sensor protein DegS OmpH PF03938.14 EMC84306.1 - 0.95 9.8 12.5 1.4 9.3 12.5 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Snapin_Pallidin PF14712.6 EMC84306.1 - 0.98 9.9 9.1 66 4.0 9.0 2.2 1 1 0 1 1 1 0 Snapin/Pallidin CdvA PF18822.1 EMC84306.1 - 1 9.2 6.2 8.5 6.2 6.2 1.9 1 1 0 1 1 1 0 CdvA-like coiled-coil domain Macoilin PF09726.9 EMC84306.1 - 1.1 7.8 6.6 1.5 7.3 6.6 1.1 1 0 0 1 1 1 0 Macoilin family FmiP_Thoc5 PF09766.9 EMC84306.1 - 1.3 8.3 8.6 1.8 7.8 8.6 1.1 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 DUF2730 PF10805.8 EMC84306.1 - 2.1 8.5 5.5 0.72 10.0 1.8 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2730) DUF2570 PF10828.8 EMC84306.1 - 2.2 8.1 9.6 1.8 8.4 4.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) TMF_DNA_bd PF12329.8 EMC84306.1 - 2.2 8.3 13.0 4.6 7.3 1.3 2.6 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF1664 PF07889.12 EMC84306.1 - 2.3 8.3 5.7 8.8 6.4 5.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Prefoldin_2 PF01920.20 EMC84306.1 - 3 7.8 11.4 7.4 6.6 2.8 2.1 2 0 0 2 2 2 0 Prefoldin subunit Spc24 PF08286.11 EMC84306.1 - 4 7.7 9.7 1.4 9.2 2.1 2.3 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 HIP1_clath_bdg PF16515.5 EMC84306.1 - 4.9 7.8 17.4 17 6.1 8.8 2.1 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 SlyX PF04102.12 EMC84306.1 - 7.1 7.3 14.1 1.8 9.2 3.5 2.3 1 1 1 2 2 2 0 SlyX YebO PF13974.6 EMC84307.1 - 0.26 11.4 1.4 0.4 10.8 1.4 1.3 1 0 0 1 1 1 0 YebO-like protein DUF3522 PF12036.8 EMC84308.1 - 2.2e-09 37.9 4.9 3.9e-09 37.1 4.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3522) Plasmod_Pvs28 PF06247.11 EMC84308.1 - 0.72 10.2 5.6 1.9 8.8 5.6 1.7 1 0 0 1 1 1 0 Pvs28 EGF domain EGF_2 PF07974.13 EMC84308.1 - 5.3 7.5 8.5 16 5.9 8.5 1.9 1 0 0 1 1 1 0 EGF-like domain ANF_receptor PF01094.28 EMC84311.1 - 9.1e-15 54.6 0.2 1.1e-14 54.3 0.2 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region PSP94 PF05825.11 EMC84312.1 - 2.5e-08 34.4 6.0 3.3e-08 34.0 6.0 1.1 1 0 0 1 1 1 1 Beta-microseminoprotein (PSP-94) VWC PF00093.18 EMC84312.1 - 0.0063 16.8 4.9 0.014 15.7 4.9 1.7 1 1 0 1 1 1 1 von Willebrand factor type C domain TILa PF12714.7 EMC84312.1 - 0.11 12.5 7.9 0.24 11.4 7.9 1.8 1 1 0 1 1 1 0 TILa domain Rgp1 PF08737.10 EMC84313.1 - 2.4e-47 162.1 0.5 4.2e-24 85.5 0.0 2.4 1 1 1 2 2 2 2 Rgp1 Arrestin_N PF00339.29 EMC84313.1 - 0.063 13.3 0.2 0.24 11.4 0.0 2.1 2 0 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain DUF608 PF04685.13 EMC84314.1 - 3.4e-162 539.7 2.3 4.5e-162 539.3 2.3 1.1 1 0 0 1 1 1 1 Glycosyl-hydrolase family 116, catalytic region Glyco_hydr_116N PF12215.8 EMC84314.1 - 8e-62 209.5 0.0 1.3e-61 208.8 0.0 1.3 1 0 0 1 1 1 1 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term GDE_C PF06202.14 EMC84314.1 - 0.0028 16.7 0.1 0.0043 16.0 0.1 1.2 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Bac_rhamnosid6H PF17389.2 EMC84314.1 - 0.0084 15.4 0.1 0.014 14.6 0.1 1.3 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain DUF5127 PF17168.4 EMC84314.1 - 0.058 13.2 0.0 0.096 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5127) Avidin PF01382.17 EMC84315.1 - 1.6e-39 134.9 4.7 1.8e-39 134.7 4.7 1.0 1 0 0 1 1 1 1 Avidin family Avidin PF01382.17 EMC84316.1 - 3.6e-36 124.1 0.1 4e-36 124.0 0.1 1.0 1 0 0 1 1 1 1 Avidin family Avidin PF01382.17 EMC84317.1 - 2.4e-35 121.5 0.2 2.7e-35 121.3 0.2 1.0 1 0 0 1 1 1 1 Avidin family Avidin PF01382.17 EMC84318.1 - 4.3e-31 107.7 1.6 5e-31 107.6 1.6 1.0 1 0 0 1 1 1 1 Avidin family Avidin PF01382.17 EMC84319.1 - 1.5e-25 89.9 0.0 1.6e-25 89.8 0.0 1.0 1 0 0 1 1 1 1 Avidin family bZIP_1 PF00170.21 EMC84320.1 - 9.2e-13 48.1 15.9 9.2e-13 48.1 15.9 2.1 2 1 1 3 3 3 2 bZIP transcription factor bZIP_2 PF07716.15 EMC84320.1 - 4.5e-09 36.2 13.0 4.5e-09 36.2 13.0 2.7 2 1 1 3 3 3 2 Basic region leucine zipper bZIP_Maf PF03131.17 EMC84320.1 - 3.7e-06 27.4 12.3 6.6e-06 26.5 12.3 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor ZapB PF06005.12 EMC84320.1 - 0.025 15.0 3.7 0.025 15.0 3.7 2.3 2 1 0 2 2 2 0 Cell division protein ZapB GCN5L1 PF06320.13 EMC84320.1 - 0.034 14.3 7.6 0.047 13.8 7.6 1.2 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) ADIP PF11559.8 EMC84320.1 - 0.042 13.9 14.5 0.054 13.6 14.5 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding HAUS-augmin3 PF14932.6 EMC84320.1 - 0.047 13.3 7.8 0.055 13.0 7.8 1.3 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 JMY PF15871.5 EMC84320.1 - 0.063 12.6 7.9 0.074 12.3 7.9 1.1 1 0 0 1 1 1 0 Junction-mediating and -regulatory protein PHM7_cyt PF14703.6 EMC84320.1 - 0.089 13.0 2.3 0.12 12.6 2.3 1.1 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Ntox33 PF15533.6 EMC84320.1 - 0.11 13.0 0.3 0.8 10.2 0.1 2.0 2 0 0 2 2 2 0 Bacterial toxin 33 DivIC PF04977.15 EMC84320.1 - 1.8 8.4 7.5 1.8 8.4 5.7 2.1 1 1 0 1 1 1 0 Septum formation initiator Aph-1 PF06105.12 EMC84321.1 - 6.3e-84 281.0 12.6 7.1e-84 280.8 12.6 1.0 1 0 0 1 1 1 1 Aph-1 protein YqfD PF06898.11 EMC84321.1 - 0.012 14.5 0.4 0.018 13.9 0.4 1.2 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD OST3_OST6 PF04756.13 EMC84321.1 - 0.95 8.7 6.5 0.25 10.7 1.9 2.0 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family BCL_N PF04714.13 EMC84322.1 - 0.057 13.5 0.0 0.097 12.7 0.0 1.3 1 0 0 1 1 1 0 BCL7, N-terminal conserver region Carb_anhydrase PF00194.21 EMC84323.1 - 6.2e-86 288.1 0.0 7.1e-86 287.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Collagen PF01391.18 EMC84324.1 - 1.7e-14 53.3 48.4 7.6e-08 32.0 26.3 2.4 2 0 0 2 2 2 2 Collagen triple helix repeat (20 copies) FXa_inhibition PF14670.6 EMC84324.1 - 2.8e-11 43.5 23.3 6.7e-09 35.9 10.5 2.7 2 0 0 2 2 2 2 Coagulation Factor Xa inhibitory site cEGF PF12662.7 EMC84324.1 - 3.7e-10 39.5 11.6 1.7e-05 24.6 3.3 3.0 2 0 0 2 2 2 2 Complement Clr-like EGF-like EGF_CA PF07645.15 EMC84324.1 - 1.4e-09 38.0 9.7 1.4e-09 38.0 9.7 2.8 2 1 0 2 2 2 1 Calcium-binding EGF domain EGF PF00008.27 EMC84324.1 - 0.00022 21.5 18.9 0.0069 16.7 5.4 2.8 2 0 0 2 2 2 2 EGF-like domain EGF_3 PF12947.7 EMC84324.1 - 0.012 15.8 23.0 0.18 12.0 4.6 2.8 2 0 0 2 2 2 0 EGF domain Tme5_EGF_like PF09064.10 EMC84324.1 - 0.89 9.5 18.6 0.74 9.8 5.1 2.6 2 0 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like Keratin PF02422.16 EMC84326.1 - 1.5e-41 139.9 14.3 1.8e-41 139.8 14.3 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC84327.1 - 2.4e-41 139.3 14.6 2.8e-41 139.1 14.6 1.0 1 0 0 1 1 1 1 Keratin zf-U11-48K PF05253.12 EMC84329.1 - 2.5e-21 75.1 10.4 9e-11 41.4 0.2 2.2 2 0 0 2 2 2 2 U11-48K-like CHHC zinc finger zf-TRAF_2 PF15965.5 EMC84329.1 - 0.019 15.4 1.0 0.029 14.8 1.0 1.2 1 0 0 1 1 1 0 TRAF-like zinc-finger zf-TRAF PF02176.18 EMC84329.1 - 0.32 11.7 4.9 0.74 10.6 0.2 2.6 2 1 1 3 3 3 0 TRAF-type zinc finger V-SNARE_C PF12352.8 EMC84330.1 - 1.4e-17 63.7 4.2 1.6e-17 63.5 1.4 2.3 1 1 1 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EMC84330.1 - 2.6e-05 24.1 0.4 5.2e-05 23.1 0.1 1.7 2 0 0 2 2 2 1 Sec20 V-SNARE PF05008.15 EMC84330.1 - 0.00074 19.8 1.9 0.0015 18.9 1.9 1.5 1 0 0 1 1 1 1 Vesicle transport v-SNARE protein N-terminus EzrA PF06160.12 EMC84330.1 - 0.019 13.1 4.7 0.024 12.8 4.7 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA EF-G-binding_N PF07299.11 EMC84330.1 - 0.039 14.5 2.2 0.066 13.7 0.6 2.1 1 1 1 2 2 2 0 Elongation factor G-binding protein, N-terminal DUF2344 PF10105.9 EMC84330.1 - 0.055 13.3 0.2 0.075 12.9 0.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) HSCB_C PF07743.13 EMC84330.1 - 0.056 13.9 0.9 0.39 11.2 0.2 2.4 2 1 1 3 3 3 0 HSCB C-terminal oligomerisation domain Ran-binding PF05508.11 EMC84330.1 - 0.061 12.3 1.8 0.089 11.8 1.8 1.1 1 0 0 1 1 1 0 RanGTP-binding protein DUF1690 PF07956.11 EMC84330.1 - 0.27 11.6 5.4 0.55 10.6 5.4 1.5 1 1 0 1 1 1 0 Protein of Unknown function (DUF1690) FlxA PF14282.6 EMC84330.1 - 0.49 10.4 4.0 1.4 8.9 0.2 2.2 1 1 1 2 2 2 0 FlxA-like protein GIT_CC PF16559.5 EMC84330.1 - 0.49 10.3 3.3 2.8 7.9 0.0 2.8 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor wnt PF00110.19 EMC84331.1 - 3.2e-96 322.5 14.9 3.7e-96 322.3 14.9 1.0 1 0 0 1 1 1 1 wnt family wnt PF00110.19 EMC84332.1 - 1.1e-124 416.0 16.0 1.3e-124 415.8 16.0 1.0 1 0 0 1 1 1 1 wnt family AAA PF00004.29 EMC84333.1 - 1.2e-57 193.9 0.0 1.8e-41 141.7 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.18 EMC84333.1 - 3.7e-12 46.3 0.0 7.7e-11 42.0 0.0 2.4 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain AAA_lid_3 PF17862.1 EMC84333.1 - 7.5e-11 41.7 0.4 1.5e-10 40.7 0.4 1.5 1 0 0 1 1 1 1 AAA+ lid domain CDC48_2 PF02933.17 EMC84333.1 - 3.4e-10 39.5 1.4 2.4e-09 36.8 0.1 2.6 3 0 0 3 3 2 1 Cell division protein 48 (CDC48), domain 2 AAA_22 PF13401.6 EMC84333.1 - 1.5e-09 38.2 0.2 0.014 15.6 0.0 4.3 2 2 2 4 4 4 2 AAA domain AAA_16 PF13191.6 EMC84333.1 - 2.9e-08 34.3 0.0 0.0036 17.7 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain RuvB_N PF05496.12 EMC84333.1 - 4.7e-08 32.9 0.0 0.011 15.5 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EMC84333.1 - 5.7e-08 33.1 0.0 0.013 15.8 0.0 3.4 4 0 0 4 4 2 2 RNA helicase AAA_2 PF07724.14 EMC84333.1 - 6.5e-08 32.9 0.0 8e-06 26.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 EMC84333.1 - 7.5e-07 29.2 0.0 0.027 14.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EMC84333.1 - 8.3e-07 29.1 0.0 0.0011 19.0 0.1 3.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EMC84333.1 - 2.2e-06 28.3 0.0 0.018 15.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 EMC84333.1 - 2.7e-06 26.8 0.0 0.048 12.9 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_33 PF13671.6 EMC84333.1 - 3e-06 27.5 0.0 0.096 12.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EMC84333.1 - 1.2e-05 24.8 0.1 0.0045 16.4 0.1 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 EMC84333.1 - 2.1e-05 24.6 0.2 0.32 10.9 0.1 4.0 2 2 2 4 4 4 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EMC84333.1 - 3.5e-05 23.6 0.0 0.13 12.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 EMC84333.1 - 4.1e-05 23.6 0.0 0.06 13.3 0.0 2.6 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EMC84333.1 - 0.00011 22.2 0.0 0.76 9.7 0.0 3.6 3 1 0 3 3 3 2 NACHT domain AAA_17 PF13207.6 EMC84333.1 - 0.00058 20.3 0.0 1.6 9.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain ATPase PF06745.13 EMC84333.1 - 0.0012 18.2 0.1 0.02 14.2 0.0 2.7 2 1 1 3 3 3 1 KaiC AAA_3 PF07726.11 EMC84333.1 - 0.0028 17.5 0.0 0.4 10.6 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EMC84333.1 - 0.0029 17.9 0.0 0.31 11.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EMC84333.1 - 0.0034 16.7 0.0 1.4 8.2 0.0 2.9 3 0 0 3 3 3 1 Zeta toxin ABC_tran PF00005.27 EMC84333.1 - 0.0036 17.8 0.0 0.018 15.6 0.0 2.1 2 0 0 2 2 1 1 ABC transporter Sigma54_activat PF00158.26 EMC84333.1 - 0.0046 16.7 0.0 1.7 8.3 0.0 2.7 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_7 PF12775.7 EMC84333.1 - 0.005 16.4 0.0 0.1 12.1 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region KTI12 PF08433.10 EMC84333.1 - 0.0051 16.3 0.6 4.1 6.8 0.0 3.4 4 0 0 4 4 4 1 Chromatin associated protein KTI12 IstB_IS21 PF01695.17 EMC84333.1 - 0.0091 15.7 0.0 0.3 10.8 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_25 PF13481.6 EMC84333.1 - 0.0093 15.6 0.2 2.1 7.9 0.0 3.2 3 0 0 3 3 3 1 AAA domain NB-ARC PF00931.22 EMC84333.1 - 0.01 15.1 0.0 1.1 8.4 0.1 2.4 2 0 0 2 2 2 0 NB-ARC domain AAA_11 PF13086.6 EMC84333.1 - 0.015 15.1 0.1 1.3 8.8 0.1 2.6 2 1 0 2 2 2 0 AAA domain Rad17 PF03215.15 EMC84333.1 - 0.017 15.1 0.1 0.21 11.5 0.0 2.7 3 1 0 3 3 3 0 Rad17 P-loop domain Parvo_NS1 PF01057.17 EMC84333.1 - 0.018 14.1 0.0 2.3 7.2 0.0 2.6 3 0 0 3 3 3 0 Parvovirus non-structural protein NS1 AAA_19 PF13245.6 EMC84333.1 - 0.057 13.7 0.2 4.2 7.7 0.0 3.2 3 0 0 3 3 3 0 AAA domain CPT PF07931.12 EMC84333.1 - 0.096 12.5 0.0 1.6 8.6 0.0 2.5 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein NTPase_1 PF03266.15 EMC84333.1 - 0.1 12.5 0.0 17 5.3 0.0 2.8 2 1 0 2 2 2 0 NTPase MEIOC PF15189.6 EMC84334.1 - 6e-06 26.0 0.8 8e-06 25.6 0.1 1.6 2 0 0 2 2 2 1 Meiosis-specific coiled-coil domain-containing protein MEIOC MEIOC PF15189.6 EMC84335.1 - 1.1e-35 122.7 0.7 1.2e-35 122.5 0.7 1.0 1 0 0 1 1 1 1 Meiosis-specific coiled-coil domain-containing protein MEIOC RBD-FIP PF09457.10 EMC84336.1 - 3.2 7.7 5.9 3.3 7.7 0.1 3.3 3 0 0 3 3 3 0 FIP domain zf-DBF PF07535.12 EMC84337.1 - 1.4e-18 66.7 0.6 2.4e-18 66.0 0.6 1.4 1 0 0 1 1 1 1 DBF zinc finger Reprolysin PF01421.19 EMC84338.1 - 5.1e-65 219.1 0.0 5.1e-65 219.1 0.0 1.7 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.19 EMC84338.1 - 6.8e-27 94.4 1.5 6.8e-27 94.4 1.5 2.1 2 0 0 2 2 2 1 Reprolysin family propeptide ADAM_CR PF08516.12 EMC84338.1 - 2.2e-22 79.6 3.4 2.2e-22 79.6 3.4 3.6 3 1 1 4 4 4 1 ADAM cysteine-rich Disintegrin PF00200.23 EMC84338.1 - 2.1e-15 57.3 29.9 2.1e-15 57.3 29.9 3.9 4 0 0 4 4 4 1 Disintegrin Reprolysin_3 PF13582.6 EMC84338.1 - 3.5e-10 40.5 0.0 7e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EMC84338.1 - 6.4e-10 39.5 0.1 1.4e-09 38.4 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 EMC84338.1 - 8.1e-05 22.6 0.1 0.0002 21.3 0.1 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.13 EMC84338.1 - 0.00052 20.3 10.7 0.00052 20.3 10.7 6.5 7 1 0 7 7 7 1 EGF-like domain EGF_Tenascin PF18720.1 EMC84338.1 - 0.0015 18.5 3.4 0.0015 18.5 3.4 3.5 3 0 0 3 3 3 1 Tenascin EGF domain GTP_EFTU PF00009.27 EMC84339.1 - 6.1e-46 156.4 0.0 9.3e-46 155.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 EMC84339.1 - 1.2e-38 132.4 9.1 2e-38 131.7 9.1 1.4 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 EMC84339.1 - 1.1e-23 83.2 0.0 2.4e-23 82.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EMC84339.1 - 9.8e-23 80.0 0.0 2.2e-22 78.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EMC84339.1 - 1e-12 48.3 0.0 2.7e-12 46.9 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EMC84339.1 - 3.1e-08 33.6 0.0 8.3e-08 32.2 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II Septin PF00735.18 EMC84339.1 - 0.061 12.6 0.0 0.099 11.9 0.0 1.2 1 0 0 1 1 1 0 Septin Dynein_attach_N PF15867.5 EMC84340.1 - 1.5e-07 31.2 0.1 2.1e-07 30.8 0.1 1.2 1 0 0 1 1 1 1 Dynein attachment factor N-terminus V-set PF07686.17 EMC84341.1 - 1.9e-09 37.6 0.1 2.7e-05 24.3 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC84341.1 - 1.1e-08 35.5 0.0 0.0037 17.8 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 EMC84341.1 - 5.1e-08 33.0 0.0 0.0085 16.2 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC84341.1 - 5.8e-05 23.1 0.0 0.088 12.9 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC84341.1 - 0.00018 21.8 0.0 0.018 15.4 0.0 2.6 2 1 0 2 2 2 1 Immunoglobulin domain Ig_6 PF18452.1 EMC84341.1 - 0.0047 16.5 0.0 0.35 10.5 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain Receptor_2B4 PF11465.8 EMC84341.1 - 0.17 12.1 0.0 0.76 10.0 0.0 2.1 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 Filament PF00038.21 EMC84342.1 - 2.1e-79 267.4 26.9 7.9e-48 163.6 5.2 2.9 1 1 1 2 2 2 2 Intermediate filament protein Filament_head PF04732.14 EMC84342.1 - 4.1e-06 27.6 0.2 2.5e-05 25.1 0.0 2.3 2 0 0 2 2 2 1 Intermediate filament head (DNA binding) region ApoO PF09769.9 EMC84342.1 - 0.023 14.6 4.0 0.1 12.6 0.0 3.4 4 0 0 4 4 4 0 Apolipoprotein O KLRAQ PF10205.9 EMC84342.1 - 0.09 13.0 0.2 0.09 13.0 0.2 3.8 2 2 2 5 5 5 0 Predicted coiled-coil domain-containing protein FlgN PF05130.12 EMC84342.1 - 0.31 11.6 16.5 0.32 11.5 0.7 2.8 1 1 2 3 3 3 0 FlgN protein Sun2_CC2 PF18580.1 EMC84342.1 - 0.77 10.0 6.1 0.93 9.8 1.4 2.8 2 0 0 2 2 2 0 SUN2 coiled coil domain 2 Syntaxin_2 PF14523.6 EMC84342.1 - 1.2 9.5 9.1 0.56 10.6 2.1 2.9 3 1 0 3 3 3 0 Syntaxin-like protein ACCA PF03255.14 EMC84342.1 - 4 7.3 11.2 4.5 7.1 0.8 3.1 3 1 0 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit AAA_13 PF13166.6 EMC84342.1 - 5.2 5.6 16.8 0.24 10.0 10.3 1.8 2 0 0 2 2 2 0 AAA domain Kinesin PF00225.23 EMC84343.1 - 4.5e-108 361.1 0.0 5.6e-108 360.8 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EMC84343.1 - 7.7e-24 84.3 0.0 2.1e-23 82.9 0.0 1.7 2 0 0 2 2 2 1 Microtubule binding C1q PF00386.21 EMC84344.1 - 2e-35 121.7 0.1 2.4e-35 121.5 0.1 1.0 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 EMC84344.1 - 0.0001 22.2 0.0 0.00014 21.7 0.0 1.2 1 0 0 1 1 1 1 BclA C-terminal domain Collagen PF01391.18 EMC84345.1 - 5.2e-16 58.2 76.5 1.9 8.3 27.1 3.6 1 1 1 2 2 2 1 Collagen triple helix repeat (20 copies) Pentapeptide_4 PF13599.6 EMC84346.1 - 0.0054 16.9 0.0 23 5.2 0.0 4.3 3 2 0 4 4 4 2 Pentapeptide repeats (9 copies) GTP_EFTU_D3 PF03143.17 EMC84347.1 - 1.2e-09 38.5 0.0 1.3e-09 38.4 0.0 1.0 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain FBPase PF00316.20 EMC84349.1 - 3.7e-74 248.3 0.1 5.1e-74 247.8 0.1 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 EMC84349.1 - 0.00019 21.0 0.0 0.00037 20.1 0.0 1.4 1 0 0 1 1 1 1 Inositol monophosphatase family ABC2_membrane PF01061.24 EMC84349.1 - 0.02 14.3 0.1 0.052 12.9 0.0 1.6 2 0 0 2 2 2 0 ABC-2 type transporter Peptidase_C1 PF00112.23 EMC84350.1 - 6.6e-89 297.7 2.8 9.8e-89 297.1 2.8 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EMC84350.1 - 8e-13 48.6 1.9 1.7e-12 47.6 1.9 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EMC84350.1 - 2.5e-06 26.6 2.8 0.00032 19.6 1.0 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Styelin PF17562.2 EMC84350.1 - 0.053 13.9 0.1 0.14 12.6 0.1 1.7 1 0 0 1 1 1 0 Styelin Lipocalin_8 PF16585.5 EMC84350.1 - 0.096 13.1 1.5 0.17 12.3 1.5 1.4 1 0 0 1 1 1 0 Lipocalin-like domain Pkinase PF00069.25 EMC84351.1 - 1.8e-70 237.3 0.0 2.6e-70 236.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 EMC84351.1 - 1.9e-53 179.0 4.7 2.6e-15 56.8 0.1 4.9 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC84351.1 - 4e-46 154.8 4.2 4.2e-10 40.0 0.0 6.8 3 1 3 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC84351.1 - 3.3e-43 145.2 13.5 8.5e-09 35.5 0.0 7.9 1 1 6 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.30 EMC84351.1 - 2.1e-38 129.1 7.6 8.7e-06 26.0 0.2 9.0 9 0 0 9 9 9 7 Ankyrin repeat Ank_3 PF13606.6 EMC84351.1 - 8.4e-37 121.0 8.1 7.3e-05 22.9 0.0 8.8 8 0 0 8 8 8 8 Ankyrin repeat Pkinase_Tyr PF07714.17 EMC84351.1 - 4.3e-34 118.0 0.0 7.4e-34 117.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMC84351.1 - 5.9e-06 25.8 0.1 1.5e-05 24.4 0.1 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EMC84351.1 - 0.00011 21.8 0.0 0.00023 20.8 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Roc PF08477.13 EMC84351.1 - 0.01 16.1 0.1 2.1 8.6 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Kinase-like PF14531.6 EMC84351.1 - 0.026 13.8 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Choline_kinase PF01633.20 EMC84351.1 - 0.032 13.8 0.0 0.071 12.7 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase AAA_23 PF13476.6 EMC84351.1 - 0.04 14.4 0.3 0.13 12.7 0.0 2.0 3 0 0 3 3 3 0 AAA domain APH PF01636.23 EMC84351.1 - 0.051 13.5 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3847 PF12958.7 EMC84351.1 - 0.079 13.1 0.2 0.28 11.3 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) TUTF7_u4 PF16631.5 EMC84353.1 - 2.4e-32 111.4 14.6 2.4e-32 111.4 14.6 2.8 4 0 0 4 4 1 1 Unstructured region 4 on terminal uridylyltransferase 7 PAP_assoc PF03828.19 EMC84353.1 - 6.7e-26 90.3 4.2 2.7e-14 53.1 0.2 3.3 4 0 0 4 4 4 2 Cid1 family poly A polymerase zf-CCHC PF00098.23 EMC84353.1 - 2.1e-14 52.8 19.5 3.4e-05 23.7 2.3 3.9 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 EMC84353.1 - 3.8e-06 26.6 27.6 0.012 15.5 5.7 4.5 4 0 0 4 4 4 3 Zinc knuckle NTP_transf_2 PF01909.23 EMC84353.1 - 8.6e-06 26.0 0.0 5.7e-05 23.3 0.0 2.5 2 0 0 2 2 2 1 Nucleotidyltransferase domain zf-CCHC_4 PF14392.6 EMC84353.1 - 0.00079 19.1 13.3 0.24 11.2 0.3 3.8 3 0 0 3 3 3 2 Zinc knuckle tRNA_NucTransf2 PF09249.11 EMC84353.1 - 0.00083 19.6 0.0 3 8.1 0.0 2.9 2 0 0 2 2 2 2 tRNA nucleotidyltransferase, second domain Polbeta PF18765.1 EMC84353.1 - 0.0057 16.7 0.0 0.061 13.4 0.0 2.5 2 0 0 2 2 2 1 Polymerase beta, Nucleotidyltransferase Spt46 PF17734.1 EMC84353.1 - 0.044 13.6 0.5 1 9.2 0.1 2.5 2 0 0 2 2 2 0 Spermatogenesis-associated protein 46 zf-C2H2_jaz PF12171.8 EMC84353.1 - 0.05 13.9 3.4 0.18 12.2 3.4 2.1 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Succ_CoA_lig PF13607.6 EMC84353.1 - 0.13 12.0 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Succinyl-CoA ligase like flavodoxin domain Fe-S_biosyn PF01521.20 EMC84354.1 - 1.1e-18 67.5 0.0 1.2e-18 67.3 0.0 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis GyrI-like PF06445.15 EMC84355.1 - 0.032 14.5 0.1 0.069 13.5 0.1 1.5 1 0 0 1 1 1 0 GyrI-like small molecule binding domain Focal_AT PF03623.13 EMC84355.1 - 0.55 10.2 6.8 0.69 9.9 2.0 2.9 1 1 2 3 3 3 0 Focal adhesion targeting region DUF148 PF02520.17 EMC84355.1 - 0.75 9.9 14.7 0.37 10.9 6.8 3.4 1 1 1 2 2 2 0 Domain of unknown function DUF148 FliT PF05400.13 EMC84355.1 - 1.1 10.1 20.4 0.15 12.9 4.9 3.7 3 2 1 4 4 4 0 Flagellar protein FliT Img2 PF05046.14 EMC84355.1 - 1.4 9.2 5.9 2.9 8.3 4.3 2.5 1 1 1 2 2 2 0 Mitochondrial large subunit ribosomal protein (Img2) Leu_zip PF15294.6 EMC84355.1 - 9.6 5.6 31.1 0.12 11.9 15.1 2.2 1 1 1 2 2 2 0 Leucine zipper Mak10 PF04112.13 EMC84356.1 - 5.3e-35 120.4 2.1 9.7e-26 90.3 0.1 2.8 2 1 1 3 3 3 2 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase Rer1 PF03248.13 EMC84356.1 - 0.0017 18.2 0.8 0.0034 17.1 0.8 1.5 1 0 0 1 1 1 1 Rer1 family Pepdidase_M14_N PF18027.1 EMC84357.1 - 3.3e-16 59.6 2.4 8.6e-16 58.2 2.4 1.8 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain Peptidase_M14 PF00246.24 EMC84357.1 - 1.8e-12 47.7 0.0 4e-12 46.5 0.0 1.7 1 1 0 1 1 1 1 Zinc carboxypeptidase V-ATPase_H_N PF03224.14 EMC84357.1 - 8.9e-05 21.9 1.8 0.00028 20.3 0.0 2.5 2 1 0 2 2 2 1 V-ATPase subunit H AstE_AspA PF04952.14 EMC84357.1 - 0.0013 17.8 0.0 0.0053 15.9 0.0 1.9 2 0 0 2 2 2 1 Succinylglutamate desuccinylase / Aspartoacylase family Pkinase_Tyr PF07714.17 EMC84358.1 - 1.4e-96 322.8 0.0 1.8e-96 322.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC84358.1 - 1.4e-48 165.6 0.0 2e-48 165.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.16 EMC84358.1 - 1.8e-22 79.2 0.5 3.3e-12 46.3 0.1 2.8 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC84358.1 - 1.5e-16 60.7 4.5 1.1e-10 41.9 1.5 2.7 2 0 0 2 2 2 2 Immunoglobulin domain TPKR_C2 PF16920.5 EMC84358.1 - 5.3e-14 52.1 1.0 1.4e-13 50.8 0.4 2.1 2 0 0 2 2 2 1 Tyrosine-protein kinase receptor C2 Ig-like domain ig PF00047.25 EMC84358.1 - 2.4e-11 43.7 0.5 1.5e-07 31.5 0.2 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 EMC84358.1 - 7.7e-11 42.2 3.0 1.8e-07 31.4 0.6 2.7 2 0 0 2 2 2 2 Immunoglobulin domain LRR_8 PF13855.6 EMC84358.1 - 3.5e-10 39.5 1.1 9.5e-10 38.1 1.1 1.8 1 0 0 1 1 1 1 Leucine rich repeat Ig_C17orf99 PF17736.1 EMC84358.1 - 0.0021 18.0 0.0 0.0051 16.8 0.0 1.7 1 0 0 1 1 1 1 C17orf99 Ig domain C2-set_2 PF08205.12 EMC84358.1 - 0.0038 17.3 0.3 2 8.6 0.1 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 EMC84358.1 - 0.0073 16.5 0.7 3.6 7.8 0.0 3.2 1 1 2 3 3 3 1 Immunoglobulin V-set domain TMEM154 PF15102.6 EMC84358.1 - 0.0084 16.0 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 TMEM154 protein family Haspin_kinase PF12330.8 EMC84358.1 - 0.035 13.1 0.0 0.065 12.2 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain LRR_4 PF12799.7 EMC84358.1 - 4.9 7.7 8.2 1.1 9.8 1.1 3.1 2 1 1 3 3 2 0 Leucine Rich repeats (2 copies) RNA_pol_Rpb2_2 PF04561.14 EMC84359.1 - 0.0014 18.3 0.1 0.0039 16.8 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 DUF356 PF04009.12 EMC84359.1 - 0.12 12.6 0.2 0.94 9.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF356) TPR_19 PF14559.6 EMC84359.1 - 0.2 12.2 0.4 0.93 10.0 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Pkinase PF00069.25 EMC84360.1 - 2.5e-44 151.6 0.0 4e-44 151.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ribonuc_2-5A PF06479.12 EMC84360.1 - 8e-42 142.4 0.1 1.4e-41 141.6 0.1 1.4 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.17 EMC84360.1 - 1e-25 90.5 0.0 1.5e-25 90.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PQQ_2 PF13360.6 EMC84360.1 - 1e-07 31.8 0.0 0.0088 15.6 0.0 2.3 2 0 0 2 2 2 2 PQQ-like domain Pkinase_fungal PF17667.1 EMC84360.1 - 6.3e-06 25.2 0.0 0.00037 19.4 0.0 2.1 1 1 1 2 2 2 1 Fungal protein kinase APH PF01636.23 EMC84360.1 - 6.4e-06 26.3 0.2 0.033 14.1 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family PQQ PF01011.21 EMC84360.1 - 7.4e-06 25.6 1.1 0.11 12.4 0.0 3.8 4 0 0 4 4 4 2 PQQ enzyme repeat Kdo PF06293.14 EMC84360.1 - 0.0012 18.3 0.1 0.0022 17.4 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PQQ_3 PF13570.6 EMC84360.1 - 0.21 12.2 2.3 3 8.5 0.0 4.0 4 2 1 5 5 5 0 PQQ-like domain MMM1 PF10296.9 EMC84361.1 - 0.0014 17.8 0.0 0.0014 17.8 0.0 3.0 4 0 0 4 4 4 1 Maintenance of mitochondrial morphology protein 1 AgrB PF04647.15 EMC84361.1 - 0.099 11.9 0.1 0.16 11.2 0.1 1.2 1 0 0 1 1 1 0 Accessory gene regulator B Ig_2 PF13895.6 EMC84362.1 - 1.2e-45 153.7 4.2 4.8e-11 42.8 0.1 6.2 6 0 0 6 6 6 6 Immunoglobulin domain Ig_3 PF13927.6 EMC84362.1 - 3.5e-34 117.2 0.2 1e-05 26.1 0.0 6.5 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.25 EMC84362.1 - 8.4e-28 96.4 6.8 2.5e-05 24.4 0.1 7.4 6 2 0 6 6 6 6 Immunoglobulin domain I-set PF07679.16 EMC84362.1 - 6.7e-15 54.9 13.7 0.0098 15.9 0.1 7.6 6 3 0 6 6 6 5 Immunoglobulin I-set domain V-set PF07686.17 EMC84362.1 - 2.9e-13 50.0 9.5 0.047 13.9 0.1 7.4 6 2 2 8 8 8 4 Immunoglobulin V-set domain Ig_C17orf99 PF17736.1 EMC84362.1 - 2.9e-11 43.3 0.0 0.002 18.1 0.0 5.1 5 0 0 5 5 5 2 C17orf99 Ig domain Ig_6 PF18452.1 EMC84362.1 - 1.8e-08 33.8 0.1 1.4 8.6 0.0 4.9 5 0 0 5 5 5 3 Immunoglobulin domain Izumo-Ig PF16706.5 EMC84362.1 - 2.5e-07 30.7 3.8 0.11 12.5 0.1 5.3 5 0 0 5 5 5 1 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 EMC84362.1 - 3.2e-07 30.5 3.0 3 8.2 0.0 5.4 5 0 0 5 5 5 2 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 EMC84362.1 - 8e-06 26.2 3.6 0.011 16.1 0.0 5.1 6 0 0 6 6 6 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_C19orf38 PF17737.1 EMC84362.1 - 5.1e-05 23.5 0.1 0.44 10.9 0.0 4.5 6 0 0 6 6 6 1 Ig domain in C19orf38 (HIDE1) C2-set PF05790.15 EMC84362.1 - 0.0054 16.9 4.0 1.9 8.7 0.0 4.8 4 0 0 4 4 4 1 Immunoglobulin C2-set domain V-set_CD47 PF08204.11 EMC84362.1 - 0.051 13.5 1.1 1.7 8.7 0.1 3.5 4 0 0 4 4 4 0 CD47 immunoglobulin-like domain Ig_C17orf99 PF17736.1 EMC84363.1 - 4.4e-11 42.7 0.0 7.6e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 C17orf99 Ig domain Ig_3 PF13927.6 EMC84363.1 - 2.6e-10 40.8 0.1 6.6e-10 39.5 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 EMC84363.1 - 1.5e-09 38.0 0.1 2.7e-09 37.2 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC84363.1 - 0.0018 18.4 0.1 0.005 17.0 0.1 1.8 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC84363.1 - 0.002 18.2 0.0 0.0055 16.8 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_C19orf38 PF17737.1 EMC84363.1 - 0.012 16.0 0.0 0.023 15.0 0.0 1.4 1 0 0 1 1 1 0 Ig domain in C19orf38 (HIDE1) HGTP_anticodon PF03129.20 EMC84364.1 - 3.7e-11 43.0 0.0 6e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 Anticodon binding domain DEAD PF00270.29 EMC84365.1 - 1.1e-48 165.4 0.0 7.5e-48 162.6 0.0 2.3 2 1 1 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC84365.1 - 2.6e-31 108.2 0.0 1e-30 106.3 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain P68HR PF08061.11 EMC84365.1 - 2e-29 101.4 20.3 1.4e-15 57.1 3.9 2.6 2 0 0 2 2 2 2 P68HR (NUC004) repeat ResIII PF04851.15 EMC84365.1 - 0.00011 22.3 0.0 0.00098 19.2 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EMC84365.1 - 0.0072 15.6 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase HECT PF00632.25 EMC84366.1 - 1.9e-102 342.9 0.0 2.5e-102 342.5 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 EMC84366.1 - 5.6e-30 103.1 9.4 2.4e-11 43.5 0.2 3.7 3 0 0 3 3 3 3 WW domain C2 PF00168.30 EMC84366.1 - 1.6e-15 57.3 0.0 3.9e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 C2 domain HPS3_N PF14761.6 EMC84366.1 - 0.052 13.1 0.0 0.091 12.3 0.0 1.3 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 Arm PF00514.23 EMC84367.1 - 1.1e-83 272.9 5.3 4.1e-11 42.5 0.0 8.6 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 EMC84367.1 - 5.4e-25 86.7 3.6 1.7e-24 85.1 2.1 2.2 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_EZ PF13513.6 EMC84367.1 - 2.2e-20 72.7 0.2 2.5e-06 27.9 0.0 5.7 4 1 1 5 5 5 3 HEAT-like repeat HEAT_2 PF13646.6 EMC84367.1 - 6.9e-12 45.6 0.1 0.0093 16.3 0.0 5.4 3 2 2 6 6 6 3 HEAT repeats HEAT PF02985.22 EMC84367.1 - 4.9e-09 35.7 2.0 0.17 12.2 0.0 6.6 8 0 0 8 8 7 2 HEAT repeat IBB PF01749.20 EMC84367.1 - 0.00019 21.8 0.1 0.00094 19.6 0.2 2.2 2 0 0 2 2 1 1 Importin beta binding domain KAP PF05804.12 EMC84367.1 - 0.0017 16.6 0.1 0.15 10.2 0.1 2.6 2 1 1 3 3 3 2 Kinesin-associated protein (KAP) UxaC PF02614.14 EMC84367.1 - 0.018 13.9 0.0 2.2 7.0 0.0 2.3 2 0 0 2 2 2 0 Glucuronate isomerase SYCP2_ARLD PF18581.1 EMC84367.1 - 0.036 14.1 0.4 29 4.6 0.0 3.8 3 1 0 4 4 4 0 Synaptonemal complex 2 armadillo-repeat-like domain ECF-ribofla_trS PF07155.12 EMC84367.1 - 0.088 12.8 0.2 0.17 11.9 0.2 1.4 1 0 0 1 1 1 0 ECF-type riboflavin transporter, S component NopRA1 PF16201.5 EMC84367.1 - 0.14 11.7 0.2 20 4.7 0.0 3.9 3 1 1 4 4 4 0 Nucleolar pre-ribosomal-associated protein 1 Endonuclease_NS PF01223.23 EMC84368.1 - 3.5e-26 92.4 0.4 4.1e-26 92.2 0.4 1.0 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Endonuclea_NS_2 PF13930.6 EMC84368.1 - 0.017 15.2 2.0 0.034 14.3 2.0 1.6 1 1 0 1 1 1 0 DNA/RNA non-specific endonuclease TAP35_44 PF07265.11 EMC84369.1 - 0.24 11.4 0.6 0.36 10.9 0.6 1.3 1 0 0 1 1 1 0 Tapetum specific protein TAP35/TAP44 MFS_2 PF13347.6 EMC84370.1 - 1.4e-21 76.6 18.7 3.2e-19 68.8 18.7 2.7 1 1 0 1 1 1 1 MFS/sugar transport protein Actin PF00022.19 EMC84371.1 - 7.5e-127 423.3 0.0 3.4e-126 421.1 0.0 1.8 1 1 0 1 1 1 1 Actin SUFU_C PF12470.8 EMC84372.1 - 3.9e-83 278.5 0.0 5.2e-83 278.1 0.0 1.2 1 0 0 1 1 1 1 Suppressor of Fused Gli/Ci N terminal binding domain SUFU PF05076.13 EMC84372.1 - 7.6e-51 172.5 0.0 1.1e-50 172.0 0.0 1.2 1 0 0 1 1 1 1 Suppressor of fused protein (SUFU) zf-C3HC4_4 PF15227.6 EMC84373.1 - 1.1e-10 41.4 8.1 1.1e-10 41.4 8.1 3.4 4 0 0 4 4 3 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 EMC84373.1 - 1.5e-09 37.6 6.5 1.5e-09 37.6 6.5 2.8 3 1 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC84373.1 - 6e-09 35.8 8.1 6e-09 35.8 8.1 2.7 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EMC84373.1 - 6.2e-08 32.4 7.8 2.8e-07 30.3 7.8 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC84373.1 - 8e-06 26.1 8.3 8e-06 26.1 8.3 3.3 3 1 0 3 3 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EMC84373.1 - 2.7e-05 23.9 6.0 2.7e-05 23.9 6.0 3.4 3 1 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 EMC84373.1 - 0.00011 22.2 7.5 0.00011 22.2 7.5 5.4 5 1 0 5 5 4 1 B-box zinc finger zf-RING_10 PF16685.5 EMC84373.1 - 0.0023 18.0 3.9 0.0023 18.0 3.9 3.3 4 1 0 4 4 1 1 zinc RING finger of MSL2 zf-RING_5 PF14634.6 EMC84373.1 - 0.013 15.5 8.3 0.013 15.5 8.3 4.0 3 2 0 3 3 2 0 zinc-RING finger domain zf-Nse PF11789.8 EMC84373.1 - 0.02 14.7 4.1 0.06 13.2 4.1 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.15 EMC84373.1 - 0.11 12.6 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 U-box domain DUF3552 PF12072.8 EMC84373.1 - 0.39 10.1 14.1 0.7 9.3 14.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) dCache_2 PF08269.11 EMC84373.1 - 0.91 8.6 4.5 1.4 8.0 4.5 1.2 1 0 0 1 1 1 0 Cache domain Exonuc_VII_L PF02601.15 EMC84373.1 - 0.92 9.0 4.6 1.3 8.5 4.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Phasin PF05597.11 EMC84373.1 - 1.1 9.3 8.4 1.9 8.5 8.4 1.3 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) CASP_C PF08172.12 EMC84373.1 - 1.4 8.2 10.4 1 8.7 8.2 1.6 1 1 0 1 1 1 0 CASP C terminal DUF1461 PF07314.11 EMC84373.1 - 1.7 8.5 2.9 2.9 7.8 2.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1461) DUF3287 PF11690.8 EMC84373.1 - 1.9 8.2 5.5 2.5 7.8 4.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3287) OEP PF02321.18 EMC84373.1 - 3 7.6 8.7 4.7 7.0 8.7 1.2 1 0 0 1 1 1 0 Outer membrane efflux protein zf-RING_6 PF14835.6 EMC84373.1 - 4.4 7.3 10.9 0.074 12.9 3.0 2.2 2 0 0 2 2 1 0 zf-RING of BARD1-type protein Zn_ribbon_recom PF13408.6 EMC84373.1 - 6.6 7.3 9.3 0.94 10.0 0.1 3.6 2 1 0 2 2 1 0 Recombinase zinc beta ribbon domain Arf PF00025.21 EMC84374.1 - 4.3e-72 241.2 0.0 4.9e-72 241.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EMC84374.1 - 1.8e-14 53.6 0.0 2e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EMC84374.1 - 1.9e-14 53.9 0.0 2.5e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EMC84374.1 - 1.9e-14 53.6 0.5 1.4e-08 34.3 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EMC84374.1 - 1.8e-13 50.4 0.0 2.1e-13 50.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EMC84374.1 - 1e-12 47.9 0.0 1.2e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMC84374.1 - 1.2e-08 35.0 0.0 1.7e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC84374.1 - 4.9e-05 22.9 0.0 0.0032 17.0 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA PF00004.29 EMC84374.1 - 0.00018 22.0 0.0 0.00025 21.5 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.9 EMC84374.1 - 0.0068 16.2 0.0 0.013 15.2 0.0 1.5 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.6 EMC84374.1 - 0.011 16.3 0.0 0.022 15.3 0.0 1.5 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EMC84374.1 - 0.013 15.5 0.0 5.3 6.9 0.1 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_14 PF13173.6 EMC84374.1 - 0.024 14.7 0.1 0.047 13.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 EMC84374.1 - 0.046 13.6 0.0 7.4 6.5 0.0 2.2 2 0 0 2 2 2 0 NACHT domain FeoB_N PF02421.18 EMC84374.1 - 0.053 13.1 0.1 0.17 11.4 0.1 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B cobW PF02492.19 EMC84374.1 - 0.061 12.9 0.1 7.8 6.0 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EMC84374.1 - 0.078 11.9 0.0 3.4 6.6 0.0 2.5 2 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 EMC84374.1 - 0.11 12.8 0.1 1.1 9.5 0.1 2.1 1 1 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 EMC84374.1 - 0.15 12.1 0.0 4 7.5 0.0 2.1 1 1 1 2 2 2 0 Dynamin family Mtc PF03820.17 EMC84375.1 - 4.3e-135 449.7 0.2 4.8e-135 449.6 0.2 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier WBP-1 PF11669.8 EMC84376.1 - 4.6e-45 152.5 12.9 8.9e-45 151.6 12.9 1.5 1 0 0 1 1 1 1 WW domain-binding protein 1 TMIE PF16038.5 EMC84376.1 - 0.015 15.1 0.6 0.027 14.3 0.6 1.3 1 0 0 1 1 1 0 TMIE protein p450 PF00067.22 EMC84377.1 - 1.9e-81 274.2 0.0 2.1e-81 274.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EMC84378.1 - 7.9e-31 107.3 0.0 9.8e-31 107.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_31 PF13847.6 EMC84379.1 - 1.3e-32 112.7 0.0 2.4e-32 111.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC84379.1 - 2.5e-20 73.0 0.1 1.2e-19 70.8 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC84379.1 - 2.6e-18 66.4 0.0 6.8e-18 65.1 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMC84379.1 - 2e-14 53.5 0.0 3e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EMC84379.1 - 2.1e-13 50.5 0.0 4.6e-13 49.3 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC84379.1 - 4e-12 46.7 0.0 7.7e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EMC84379.1 - 3.2e-06 27.0 0.0 4.9e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_8 PF05148.15 EMC84379.1 - 2.7e-05 24.1 0.0 8.4e-05 22.5 0.0 1.7 1 1 1 2 2 2 1 Hypothetical methyltransferase MTS PF05175.14 EMC84379.1 - 0.00084 18.9 0.0 0.0025 17.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain TehB PF03848.14 EMC84379.1 - 0.0046 16.4 0.0 0.012 15.0 0.0 1.7 2 0 0 2 2 2 1 Tellurite resistance protein TehB Methyltransf_32 PF13679.6 EMC84379.1 - 0.021 14.8 0.0 0.04 13.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 EMC84379.1 - 0.073 12.7 0.3 0.39 10.3 0.3 1.9 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_5 PF01795.19 EMC84379.1 - 0.085 12.4 0.0 0.21 11.0 0.0 1.6 2 0 0 2 2 2 0 MraW methylase family Methyltransf_16 PF10294.9 EMC84379.1 - 0.1 12.4 0.1 0.22 11.2 0.0 1.5 1 1 0 1 1 1 0 Lysine methyltransferase Peptidase_M29 PF02073.15 EMC84379.1 - 0.17 10.6 0.0 0.26 10.0 0.0 1.2 1 0 0 1 1 1 0 Thermophilic metalloprotease (M29) TylF PF05711.11 EMC84379.1 - 0.18 11.1 0.0 0.29 10.4 0.0 1.3 1 0 0 1 1 1 0 Macrocin-O-methyltransferase (TylF) DUF21 PF01595.20 EMC84380.1 - 2.7e-32 111.9 0.0 5e-32 111.0 0.0 1.4 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 EMC84380.1 - 3.2e-07 30.7 0.2 0.00036 20.9 0.0 2.7 2 0 0 2 2 2 2 CBS domain cNMP_binding PF00027.29 EMC84380.1 - 0.00011 22.2 0.0 0.013 15.6 0.0 2.6 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Nrf1_DNA-bind PF10491.9 EMC84380.1 - 0.095 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 NLS-binding and DNA-binding and dimerisation domains of Nrf1 Cupin_3 PF05899.12 EMC84380.1 - 0.15 11.7 0.1 0.31 10.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF861) 5_nucleotid PF05761.14 EMC84381.1 - 2.2e-176 587.3 0.0 2.8e-176 586.9 0.0 1.1 1 0 0 1 1 1 1 5' nucleotidase family WD40 PF00400.32 EMC84382.1 - 2e-58 193.0 10.0 2.5e-11 43.9 0.1 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 EMC84382.1 - 4.3e-43 146.6 4.6 9.3e-43 145.6 4.6 1.6 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 EMC84382.1 - 1.1e-15 57.7 0.0 0.00035 20.8 0.0 5.4 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMC84382.1 - 2.4e-09 36.4 0.6 0.0023 16.6 0.0 3.7 4 0 0 4 4 4 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EMC84382.1 - 1.8e-06 27.2 0.0 1.8 7.4 0.0 4.1 2 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EMC84382.1 - 0.0022 17.4 0.0 0.63 9.3 0.0 3.6 4 1 1 5 5 5 1 WD40-like domain RAB3GAP2_N PF14655.6 EMC84382.1 - 0.0069 15.7 0.0 0.11 11.7 0.0 2.4 1 1 1 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Cytochrom_D1 PF02239.16 EMC84382.1 - 0.042 12.4 0.0 2.3 6.6 0.0 2.3 2 0 0 2 2 2 0 Cytochrome D1 heme domain PD40 PF07676.12 EMC84382.1 - 0.067 13.2 0.1 26 4.9 0.1 3.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat VID27 PF08553.10 EMC84382.1 - 0.086 11.9 0.3 0.36 9.8 0.0 1.9 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain ATP_synth_reg PF14960.6 EMC84383.1 - 5.2e-27 93.1 0.3 5.9e-27 92.9 0.3 1.0 1 0 0 1 1 1 1 ATP synthase regulation DUF1516 PF07457.11 EMC84383.1 - 0.1 12.8 0.0 0.11 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1516) Suf PF05843.14 EMC84384.1 - 9.4e-13 48.8 5.6 1e-08 35.6 1.0 4.0 1 1 3 4 4 3 3 Suppressor of forked protein (Suf) TPR_19 PF14559.6 EMC84384.1 - 4.5e-11 43.1 0.1 0.00013 22.4 0.0 3.8 2 1 3 5 5 5 5 Tetratricopeptide repeat TPR_14 PF13428.6 EMC84384.1 - 3.6e-09 36.7 6.4 0.0092 16.7 0.1 5.5 1 1 4 5 5 5 3 Tetratricopeptide repeat TPR_15 PF13429.6 EMC84384.1 - 1.3e-07 31.1 6.5 0.00046 19.5 0.6 3.2 1 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMC84384.1 - 4.1e-06 27.4 0.1 0.008 16.8 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMC84384.1 - 4.6e-05 23.6 3.5 0.005 17.1 0.0 3.5 2 1 1 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC84384.1 - 0.00061 20.0 0.5 0.97 9.7 0.5 3.0 2 1 2 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 EMC84384.1 - 0.0053 16.8 5.9 2 8.7 0.2 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat BTAD PF03704.17 EMC84384.1 - 0.035 14.6 0.8 9.6 6.6 0.0 3.0 1 1 2 3 3 3 0 Bacterial transcriptional activator domain FAM124 PF15067.6 EMC84384.1 - 0.037 13.6 0.6 0.41 10.2 0.3 2.3 2 0 0 2 2 2 0 FAM124 family Ras_bdg_2 PF14847.6 EMC84384.1 - 0.049 14.0 0.7 1.9 8.9 0.1 2.7 2 0 0 2 2 2 0 Ras-binding domain of Byr2 PPR_2 PF13041.6 EMC84384.1 - 0.13 12.4 0.1 2.3 8.5 0.1 2.8 2 0 0 2 2 2 0 PPR repeat family Ca_hom_mod PF14798.6 EMC84385.1 - 6.6e-86 287.5 0.5 7.8e-86 287.3 0.5 1.0 1 0 0 1 1 1 1 Calcium homeostasis modulator DUF1218 PF06749.12 EMC84385.1 - 0.0016 18.9 1.4 0.0083 16.6 0.5 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1218) DUF996 PF06195.13 EMC84385.1 - 0.063 13.6 0.3 0.46 10.8 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF996) Ca_hom_mod PF14798.6 EMC84386.1 - 2.2e-94 315.3 5.4 2.5e-94 315.1 5.4 1.0 1 0 0 1 1 1 1 Calcium homeostasis modulator Ca_hom_mod PF14798.6 EMC84387.1 - 4.7e-96 320.8 9.7 5.4e-96 320.6 9.7 1.0 1 0 0 1 1 1 1 Calcium homeostasis modulator Neuralized PF07177.12 EMC84388.1 - 2.9e-84 280.5 0.0 4.1e-41 140.5 0.0 2.1 2 0 0 2 2 2 2 Neuralized zf-C3HC4_3 PF13920.6 EMC84388.1 - 7.4e-13 48.1 13.3 7.4e-13 48.1 13.3 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC84388.1 - 1.4e-05 24.9 11.6 1.4e-05 24.9 11.6 3.2 4 0 0 4 4 4 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EMC84388.1 - 0.34 10.9 21.4 0.026 14.5 14.6 2.8 3 0 0 3 3 3 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EMC84388.1 - 0.53 10.2 20.0 0.081 12.8 15.0 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) PX PF00787.24 EMC84389.1 - 1.3e-16 60.6 0.1 1.4e-16 60.5 0.1 1.0 1 0 0 1 1 1 1 PX domain STN1_2 PF09170.10 EMC84390.1 - 1.6e-68 230.4 0.7 3.4e-68 229.3 0.7 1.5 1 0 0 1 1 1 1 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 tRNA_anti-codon PF01336.25 EMC84390.1 - 7.6e-10 38.6 0.2 1.5e-09 37.7 0.2 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Stn1 PF10451.9 EMC84390.1 - 3.4e-07 29.5 0.5 1.5e-06 27.4 0.2 2.0 1 1 1 2 2 2 1 Telomere regulation protein Stn1 DUF4364 PF14277.6 EMC84390.1 - 0.089 12.5 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) tRNA_anti_2 PF13742.6 EMC84390.1 - 0.1 12.8 0.1 0.67 10.2 0.1 2.2 1 1 0 1 1 1 0 OB-fold nucleic acid binding domain DUF3136 PF11334.8 EMC84390.1 - 0.14 12.0 0.1 0.61 9.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3136) Speriolin_C PF15059.6 EMC84390.1 - 0.17 12.0 1.3 0.28 11.3 0.4 1.8 2 0 0 2 2 2 0 Speriolin C-terminus Pkinase PF00069.25 EMC84391.1 - 1.1e-67 228.2 0.0 1.1e-67 228.2 0.0 3.6 4 1 0 4 4 4 1 Protein kinase domain PKK PF12474.8 EMC84391.1 - 5e-62 208.2 97.1 2e-41 141.4 43.1 8.9 7 2 2 9 9 9 3 Polo kinase kinase Pkinase_Tyr PF07714.17 EMC84391.1 - 9.5e-48 162.7 0.0 9.5e-48 162.7 0.0 2.4 3 0 0 3 3 3 1 Protein tyrosine kinase APH PF01636.23 EMC84391.1 - 1.2 9.0 0.0 1.2 9.0 0.0 3.7 3 1 0 3 3 3 0 Phosphotransferase enzyme family Mei5 PF10376.9 EMC84392.1 - 4.8e-52 176.8 8.8 5.4e-52 176.7 8.8 1.0 1 0 0 1 1 1 1 Double-strand recombination repair protein Mei5_like PF17021.5 EMC84392.1 - 0.0029 17.6 0.2 0.0048 16.9 0.2 1.3 1 0 0 1 1 1 1 Putative double-strand recombination repair-like Toxin_35 PF10530.9 EMC84392.1 - 0.2 11.7 2.3 0.37 10.8 2.3 1.4 1 0 0 1 1 1 0 Toxin with inhibitor cystine knot ICK or Knottin scaffold GST_N_3 PF13417.6 EMC84393.1 - 1.6e-22 79.7 0.0 4.9e-22 78.1 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EMC84393.1 - 8.3e-16 58.1 0.0 1.8e-15 57.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EMC84393.1 - 1.3e-13 51.0 0.0 2.3e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EMC84393.1 - 3.8e-06 27.0 0.0 7e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EMC84393.1 - 2.6e-05 24.2 0.0 5.6e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 EMC84393.1 - 0.00049 20.3 0.0 0.0013 18.9 0.0 1.7 2 0 0 2 2 2 1 Glutaredoxin GST_C PF00043.25 EMC84393.1 - 0.00064 19.9 0.0 0.001 19.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EMC84393.1 - 0.035 14.8 0.0 0.088 13.6 0.0 1.6 1 1 0 1 1 1 0 Glutathione S-transferase N-terminal domain Sortilin-Vps10 PF15902.5 EMC84394.1 - 8.8e-106 354.3 1.0 1.7e-105 353.4 0.1 1.8 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EMC84394.1 - 1.3e-37 129.8 7.5 2.1e-37 129.1 7.5 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal PKD PF00801.20 EMC84394.1 - 9.3e-17 60.7 2.5 1.8e-09 37.3 0.0 2.5 2 0 0 2 2 2 2 PKD domain BNR_6 PF15899.5 EMC84394.1 - 0.0064 16.4 5.4 0.58 10.4 0.0 4.7 4 0 0 4 4 4 1 BNR-Asp box repeat BNR_2 PF13088.6 EMC84394.1 - 0.11 11.7 0.4 2.3 7.4 0.1 2.6 2 1 0 2 2 2 0 BNR repeat-like domain BNR PF02012.20 EMC84394.1 - 0.41 10.8 24.0 1.5 9.1 0.6 7.0 7 0 0 7 7 7 0 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 EMC84395.1 - 3.6e-104 349.0 0.0 4.7e-104 348.6 0.0 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EMC84395.1 - 1.1e-36 126.7 7.5 1.8e-36 126.1 7.5 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal PKD PF00801.20 EMC84395.1 - 1.2e-10 41.0 2.2 1.1e-08 34.8 0.0 2.4 2 0 0 2 2 2 2 PKD domain BNR PF02012.20 EMC84395.1 - 0.0029 17.3 12.0 1.3 9.3 0.6 5.9 5 0 0 5 5 5 1 BNR/Asp-box repeat TNFR_16_TM PF18422.1 EMC84395.1 - 0.45 10.5 1.9 1.2 9.2 1.9 1.6 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain BNR_6 PF15899.5 EMC84395.1 - 1.3 9.3 3.2 94 3.5 0.0 4.3 4 0 0 4 4 4 0 BNR-Asp box repeat Creatinase_N_2 PF16189.5 EMC84396.1 - 8.2e-46 156.0 0.0 1.3e-45 155.4 0.0 1.3 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 EMC84396.1 - 1.5e-45 155.5 0.0 2.1e-45 155.0 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 EMC84396.1 - 1.5e-24 85.8 0.5 9e-24 83.3 0.1 2.6 3 0 0 3 3 3 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 EMC84396.1 - 2.3e-14 54.2 0.0 4.3e-12 46.8 0.0 2.5 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Aldolase_II PF00596.21 EMC84397.1 - 5.1e-38 130.9 0.0 7.9e-38 130.2 0.0 1.3 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain SWIRM-assoc_1 PF16495.5 EMC84397.1 - 0.17 11.9 1.1 24 5.0 0.0 2.8 2 0 0 2 2 2 0 SWIRM-associated region 1 HLH PF00010.26 EMC84398.1 - 1.2e-13 50.8 1.3 9.9e-12 44.6 1.4 2.5 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain KASH_CCD PF14662.6 EMC84398.1 - 0.00018 21.4 2.3 0.00029 20.7 2.3 1.4 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH SlyX PF04102.12 EMC84398.1 - 0.18 12.4 3.7 0.44 11.2 3.7 1.6 1 0 0 1 1 1 0 SlyX DivIC PF04977.15 EMC84398.1 - 0.37 10.6 3.5 0.85 9.4 3.5 1.6 1 0 0 1 1 1 0 Septum formation initiator APG6_N PF17675.1 EMC84398.1 - 0.54 10.8 9.1 0.85 10.2 8.7 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region EMP24_GP25L PF01105.24 EMC84398.1 - 3.5 7.5 5.7 0.55 10.1 1.3 1.8 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD SMN PF06003.12 EMC84399.1 - 5.3e-17 61.9 5.1 6.7e-17 61.6 3.7 1.9 1 1 0 1 1 1 1 Survival motor neuron protein (SMN) TUDOR PF00567.24 EMC84399.1 - 0.0003 20.8 0.0 0.00096 19.2 0.0 1.9 1 1 0 1 1 1 1 Tudor domain DSPc PF00782.20 EMC84400.1 - 4.9e-38 130.0 0.0 8.6e-38 129.2 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC84400.1 - 6.4e-05 22.6 0.0 8.4e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 EMC84400.1 - 0.027 14.8 0.0 0.046 14.0 0.0 1.3 1 0 0 1 1 1 0 Rit1 DUSP-like domain CDKN3 PF05706.12 EMC84400.1 - 0.065 12.9 0.1 0.12 12.0 0.1 1.4 1 1 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) DUF442 PF04273.13 EMC84400.1 - 0.14 12.2 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Putative phosphatase (DUF442) SMC_N PF02463.19 EMC84401.1 - 3.2e-68 229.5 8.0 6.4e-68 228.5 8.0 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EMC84401.1 - 3.9e-21 75.5 0.0 1.1e-20 74.1 0.0 1.9 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 EMC84401.1 - 1.9e-12 47.6 12.8 1.9e-12 47.6 12.8 5.7 2 2 3 5 5 5 2 AAA ATPase domain AAA_21 PF13304.6 EMC84401.1 - 6.8e-12 45.8 16.9 3.5e-06 27.1 0.0 4.9 4 1 0 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EMC84401.1 - 1.2e-08 35.7 47.2 1.2e-08 35.7 47.2 8.1 2 2 1 4 4 4 1 AAA domain AAA_29 PF13555.6 EMC84401.1 - 0.0042 16.8 0.0 0.0092 15.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Muted PF14942.6 EMC84401.1 - 0.01 16.2 12.5 0.01 16.2 12.5 8.3 2 2 7 9 9 9 0 Organelle biogenesis, Muted-like protein zf-C2H2_jaz PF12171.8 EMC84402.1 - 6e-06 26.4 5.5 0.0018 18.5 0.2 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC84402.1 - 0.04 14.3 7.5 0.24 11.8 0.3 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type RRM_1 PF00076.22 EMC84402.1 - 0.11 12.4 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-U1 PF06220.12 EMC84402.1 - 0.12 12.2 2.6 0.32 10.8 2.6 1.7 1 0 0 1 1 1 0 U1 zinc finger YqfD PF06898.11 EMC84402.1 - 0.45 9.3 3.7 0.91 8.3 3.7 1.4 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD FemAB PF02388.16 EMC84402.1 - 4.8 5.9 9.8 14 4.4 9.8 1.7 1 0 0 1 1 1 0 FemAB family TSC22 PF01166.18 EMC84403.1 - 1.7e-26 92.3 5.0 3.1e-26 91.4 5.0 1.5 1 0 0 1 1 1 1 TSC-22/dip/bun family YabA PF06156.13 EMC84403.1 - 0.0045 17.6 0.9 0.011 16.4 0.9 1.6 1 0 0 1 1 1 1 Initiation control protein YabA K-box PF01486.17 EMC84403.1 - 0.047 13.9 1.5 0.11 12.7 0.9 1.8 2 0 0 2 2 2 0 K-box region DivIC PF04977.15 EMC84403.1 - 0.066 13.0 1.7 0.14 12.0 1.7 1.5 1 0 0 1 1 1 0 Septum formation initiator TBK1_CCD1 PF18394.1 EMC84403.1 - 0.074 12.6 0.1 0.11 12.0 0.1 1.2 1 0 0 1 1 1 0 TANK-binding kinase 1 coiled-coil domain 1 ZapB PF06005.12 EMC84403.1 - 0.16 12.4 4.2 0.36 11.3 3.5 1.9 2 0 0 2 2 2 0 Cell division protein ZapB Polyoma_agno PF01736.16 EMC84404.1 - 0.12 12.1 0.1 0.28 11.0 0.1 1.5 1 0 0 1 1 1 0 Polyomavirus agnoprotein DNA_methylase PF00145.17 EMC84405.1 - 3.8e-36 125.1 0.0 5.9e-36 124.5 0.0 1.2 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase MTS PF05175.14 EMC84405.1 - 0.13 11.8 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Glyco_transf_29 PF00777.18 EMC84407.1 - 3.3e-80 269.4 0.0 5e-80 268.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) VHS PF00790.19 EMC84409.1 - 3.6e-44 150.1 1.7 4.8e-44 149.6 0.1 2.0 2 0 0 2 2 2 1 VHS domain SH3_1 PF00018.28 EMC84409.1 - 4.2e-16 58.3 0.1 8e-16 57.4 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC84409.1 - 1.7e-12 46.8 0.0 3e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EMC84409.1 - 1.7e-11 43.8 0.0 2.9e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain UIM PF02809.20 EMC84409.1 - 7.2e-05 22.4 1.7 0.0002 21.1 1.7 1.8 1 0 0 1 1 1 1 Ubiquitin interaction motif GAT PF03127.14 EMC84409.1 - 0.022 15.1 3.7 0.057 13.7 3.7 1.8 1 0 0 1 1 1 0 GAT domain SH3_10 PF17902.1 EMC84409.1 - 0.037 14.1 0.0 0.095 12.8 0.0 1.6 1 0 0 1 1 1 0 SH3 domain HEAT PF02985.22 EMC84409.1 - 0.45 10.9 1.5 1.3 9.5 0.1 2.4 2 0 0 2 2 2 0 HEAT repeat Lectin_C PF00059.21 EMC84410.1 - 1.7e-158 517.7 39.8 4e-24 85.4 0.1 8.9 9 0 0 9 9 9 8 Lectin C-type domain UL45 PF05473.12 EMC84410.1 - 4.4e-15 55.8 2.4 2.3e-05 24.2 0.0 5.5 5 0 0 5 5 5 3 UL45 protein, carbohydrate-binding C-type lectin-like fn2 PF00040.19 EMC84410.1 - 4.3e-14 52.5 9.9 4.3e-14 52.5 9.9 2.4 2 0 0 2 2 2 1 Fibronectin type II domain Ricin_B_lectin PF00652.22 EMC84410.1 - 3.7e-08 33.7 0.2 9.1e-08 32.4 0.2 1.7 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Xlink PF00193.17 EMC84410.1 - 4.2e-06 27.0 10.0 0.63 10.5 0.2 7.8 7 1 1 8 8 8 2 Extracellular link domain Chordopox_A33R PF05966.12 EMC84410.1 - 0.0015 17.8 4.5 0.64 9.3 0.0 5.0 6 0 0 6 6 6 1 Chordopoxvirus A33R protein Lectin_C PF00059.21 EMC84411.1 - 3e-71 237.0 14.1 5.7e-24 84.9 0.2 6.4 5 1 0 5 5 5 4 Lectin C-type domain fn2 PF00040.19 EMC84411.1 - 3.6e-12 46.4 7.2 3.6e-12 46.4 7.2 2.3 2 0 0 2 2 2 1 Fibronectin type II domain UL45 PF05473.12 EMC84411.1 - 2e-10 40.7 2.1 0.00049 19.8 0.0 4.3 2 1 2 4 4 4 2 UL45 protein, carbohydrate-binding C-type lectin-like Ricin_B_lectin PF00652.22 EMC84411.1 - 4.6e-09 36.6 0.7 1.4e-08 35.0 0.7 1.9 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Xlink PF00193.17 EMC84411.1 - 6.1e-08 32.9 0.0 0.17 12.3 0.1 4.3 4 0 0 4 4 4 3 Extracellular link domain Chordopox_A33R PF05966.12 EMC84411.1 - 8.1e-06 25.2 0.6 0.18 11.0 0.1 3.4 3 0 0 3 3 3 2 Chordopoxvirus A33R protein Intimin_C PF07979.11 EMC84411.1 - 0.047 14.1 0.1 33 5.0 0.0 3.6 4 0 0 4 4 4 0 Intimin C-type lectin domain Adeno_E3_CR1 PF02440.15 EMC84411.1 - 0.15 11.9 3.5 1.6 8.6 0.1 3.3 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 RicinB_lectin_2 PF14200.6 EMC84411.1 - 0.18 12.5 1.4 0.7 10.7 0.1 2.6 2 1 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like Lectin_C PF00059.21 EMC84412.1 - 1.6e-14 54.6 0.1 2.5e-14 53.9 0.1 1.3 1 0 0 1 1 1 1 Lectin C-type domain MHC2-interact PF09307.10 EMC84412.1 - 0.058 13.4 0.0 0.087 12.8 0.0 1.2 1 0 0 1 1 1 0 CLIP, MHC2 interacting DUF4366 PF14283.6 EMC84412.1 - 0.067 13.2 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Lectin_C PF00059.21 EMC84413.1 - 1.2e-06 29.2 4.7 0.00047 20.9 4.2 4.3 2 1 0 2 2 2 1 Lectin C-type domain FIT1_2 PF17357.2 EMC84413.1 - 0.15 12.2 0.1 0.28 11.3 0.1 1.4 1 0 0 1 1 1 0 Facilitor Of iron transport 1 and 2 Motile_Sperm PF00635.26 EMC84414.1 - 2.7e-31 107.6 0.4 4.4e-31 107.0 0.4 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ASH PF15780.5 EMC84414.1 - 0.015 15.5 0.0 0.029 14.6 0.0 1.5 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin bZIP_1 PF00170.21 EMC84414.1 - 0.015 15.4 0.4 0.028 14.5 0.4 1.4 1 0 0 1 1 1 0 bZIP transcription factor YabA PF06156.13 EMC84414.1 - 0.016 15.8 0.1 0.032 14.9 0.1 1.4 1 0 0 1 1 1 0 Initiation control protein YabA GIT_CC PF16559.5 EMC84414.1 - 0.049 13.5 0.3 0.11 12.4 0.3 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor ZapB PF06005.12 EMC84414.1 - 0.095 13.2 0.1 0.16 12.5 0.1 1.3 1 0 0 1 1 1 0 Cell division protein ZapB Ras PF00071.22 EMC84415.1 - 5.3e-38 130.2 0.0 6.9e-38 129.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC84415.1 - 7.8e-21 74.5 0.0 1.3e-20 73.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC84415.1 - 0.0002 20.9 0.0 0.0012 18.3 0.0 1.9 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EMC84415.1 - 0.0015 18.5 0.0 0.11 12.4 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Tsg PF04668.12 EMC84416.1 - 8e-46 156.1 7.6 8e-46 156.1 7.6 2.2 2 1 0 2 2 2 1 Twisted gastrulation (Tsg) protein conserved region Ank_4 PF13637.6 EMC84417.1 - 1.3e-19 70.3 0.0 1.1e-08 35.4 0.0 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC84417.1 - 1.3e-18 67.3 0.0 3e-12 46.9 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EMC84417.1 - 6.5e-18 64.3 0.1 0.00032 21.0 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EMC84417.1 - 1.6e-17 63.3 0.1 2.6e-07 30.8 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC84417.1 - 7.2e-15 53.6 0.0 9.3e-05 22.5 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat 2Fe-2S_thioredx PF01257.19 EMC84418.1 - 4.3e-66 221.2 0.1 5.2e-66 221.0 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin SOGA PF11365.8 EMC84419.1 - 3.5e-67 223.6 23.3 5.2e-38 130.1 3.1 8.2 6 2 2 9 9 9 3 Protein SOGA DUF4482 PF14818.6 EMC84419.1 - 1.5e-43 149.0 4.3 1.5e-43 149.0 4.3 7.1 6 2 1 7 7 7 1 Domain of unknown function (DUF4482) DUF4407 PF14362.6 EMC84419.1 - 0.013 14.9 0.5 0.013 14.9 0.5 6.0 3 2 1 4 4 4 0 Domain of unknown function (DUF4407) TSC22 PF01166.18 EMC84419.1 - 3 8.2 46.4 0.069 13.5 0.3 7.5 7 0 0 7 7 7 0 TSC-22/dip/bun family DUF948 PF06103.11 EMC84419.1 - 5.3 7.4 8.6 6.7 7.0 0.0 4.8 6 0 0 6 6 6 0 Bacterial protein of unknown function (DUF948) Ras PF00071.22 EMC84420.1 - 1.6e-45 154.7 0.2 1.7e-45 154.5 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC84420.1 - 2.3e-22 79.5 0.0 4.2e-22 78.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC84420.1 - 2.8e-11 43.2 0.3 3.5e-11 42.9 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC84420.1 - 2.5e-05 23.9 0.0 4.5e-05 23.1 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EMC84420.1 - 0.0028 17.1 0.2 0.0034 16.8 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Y_phosphatase PF00102.27 EMC84421.1 - 1.3e-150 499.4 0.1 7.2e-84 281.0 0.1 2.4 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 EMC84421.1 - 1.5e-24 86.1 13.7 7.6e-10 39.0 0.0 5.8 6 0 0 6 6 6 3 Fibronectin type III domain MAM PF00629.23 EMC84421.1 - 3.6e-22 79.0 0.0 1.1e-21 77.4 0.0 1.9 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu ig PF00047.25 EMC84421.1 - 2e-09 37.5 0.0 7.4e-09 35.7 0.0 2.1 2 0 0 2 2 1 1 Immunoglobulin domain DSPc PF00782.20 EMC84421.1 - 1.3e-08 34.7 0.1 0.0031 17.3 0.0 2.6 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC84421.1 - 5.2e-05 23.3 0.0 0.011 15.7 0.0 2.5 2 0 0 2 2 2 1 Tyrosine phosphatase family Ig_3 PF13927.6 EMC84421.1 - 6.4e-05 23.5 0.0 0.00033 21.2 0.0 2.2 2 0 0 2 2 1 1 Immunoglobulin domain PTPlike_phytase PF14566.6 EMC84421.1 - 0.00015 21.9 0.0 0.083 13.0 0.0 2.7 2 0 0 2 2 2 1 Inositol hexakisphosphate I-set PF07679.16 EMC84421.1 - 0.00029 20.8 0.0 0.00074 19.5 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin I-set domain Pur_ac_phosph_N PF16656.5 EMC84421.1 - 0.00051 20.6 1.6 0.61 10.7 0.1 3.8 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain Ig_2 PF13895.6 EMC84421.1 - 0.00073 19.8 0.0 0.0043 17.4 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain ECSCR PF15820.5 EMC84421.1 - 0.0075 16.1 0.0 0.018 14.9 0.0 1.5 1 0 0 1 1 1 1 Endothelial cell-specific chemotaxis regulator EphA2_TM PF14575.6 EMC84421.1 - 0.038 14.9 0.3 0.17 12.8 0.0 2.1 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Amnionless PF14828.6 EMC84421.1 - 0.059 12.2 0.4 0.12 11.2 0.1 1.6 2 0 0 2 2 2 0 Amnionless DUF948 PF06103.11 EMC84421.1 - 0.11 12.7 0.4 0.35 11.2 0.1 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DctM PF06808.12 EMC84421.1 - 0.12 11.2 0.1 0.18 10.6 0.1 1.1 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporter, DctM component LRR_8 PF13855.6 EMC84422.1 - 4e-22 77.7 45.7 1.6e-07 31.0 1.7 4.0 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EMC84422.1 - 1.5e-16 60.2 29.5 2e-06 28.0 4.5 5.5 2 1 4 7 7 7 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC84422.1 - 2.2e-06 27.4 33.6 0.66 10.7 0.2 8.7 8 2 0 8 8 8 4 Leucine Rich Repeat LRR_9 PF14580.6 EMC84422.1 - 0.00015 21.3 10.9 0.042 13.3 2.7 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 EMC84422.1 - 0.096 12.8 25.4 0.5 10.6 0.4 6.9 8 0 0 8 8 8 0 Leucine Rich repeat LRR_5 PF13306.6 EMC84422.1 - 0.11 12.4 1.3 0.18 11.8 1.3 1.3 1 0 0 1 1 1 0 BspA type Leucine rich repeat region (6 copies) DUF2371 PF10177.9 EMC84423.1 - 1.1e-60 203.9 0.0 2.3e-60 202.8 0.0 1.6 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2371) Neurensin PF14927.6 EMC84423.1 - 0.052 13.2 0.0 0.16 11.7 0.0 1.8 2 0 0 2 2 2 0 Neurensin AKAP7_NLS PF10469.9 EMC84424.1 - 2.6e-41 141.8 0.9 2.9e-41 141.6 0.9 1.0 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 EMC84424.1 - 9.5e-06 25.6 0.0 1.2e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 EMC84424.1 - 0.0026 17.9 0.1 0.31 11.2 0.0 2.5 2 1 0 2 2 2 2 LigT like Phosphoesterase HHV-1_VABD PF16852.5 EMC84428.1 - 6.1 6.9 31.9 6.1 6.9 1.0 7.4 1 1 8 9 9 9 0 Herpes viral adaptor-to-host cellular mRNA binding domain Forkhead PF00250.18 EMC84429.1 - 1.3e-07 31.8 0.1 2.5e-07 30.9 0.1 1.5 1 0 0 1 1 1 1 Forkhead domain DHHA2 PF02833.14 EMC84430.1 - 4.2e-05 23.8 0.0 8e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 DHHA2 domain FUR PF01475.19 EMC84430.1 - 0.0054 16.9 0.1 0.1 12.8 0.0 2.2 2 0 0 2 2 2 1 Ferric uptake regulator family SAM_Ste50p PF09235.10 EMC84430.1 - 0.094 13.0 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Ste50p, sterile alpha motif BNIP2 PF12496.8 EMC84431.1 - 5.7e-41 140.1 3.8 5.7e-41 140.1 3.8 8.5 8 2 0 8 8 8 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO_2 PF13716.6 EMC84431.1 - 6.2e-31 107.4 0.3 1.1e-30 106.5 0.3 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 EMC84431.1 - 1.3e-08 34.7 0.1 2.5e-08 33.8 0.1 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain Branch PF02485.21 EMC84432.1 - 6.1e-60 202.8 0.1 7.9e-60 202.4 0.1 1.1 1 0 0 1 1 1 1 Core-2/I-Branching enzyme Plasmod_dom_1 PF09715.10 EMC84432.1 - 0.051 13.6 0.0 0.34 11.0 0.0 2.4 2 0 0 2 2 2 0 Plasmodium protein of unknown function (Plasmod_dom_1) CD20 PF04103.15 EMC84433.1 - 5.5e-08 33.1 3.4 9.5e-08 32.3 3.4 1.4 1 0 0 1 1 1 1 CD20-like family PID PF00640.23 EMC84434.1 - 5.4e-52 175.6 0.7 1.2e-51 174.4 0.7 1.7 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PDZ PF00595.24 EMC84434.1 - 7.2e-28 96.8 10.3 2e-15 56.9 1.0 3.3 3 0 0 3 3 3 2 PDZ domain PDZ_6 PF17820.1 EMC84434.1 - 1.9e-16 59.6 0.3 4.2e-08 32.9 0.1 3.3 4 0 0 4 4 4 2 PDZ domain PDZ_2 PF13180.6 EMC84434.1 - 5.1e-07 29.9 0.1 6.6e-05 23.1 0.0 2.9 3 0 0 3 3 3 1 PDZ domain NRho PF16733.5 EMC84434.1 - 0.066 13.3 0.2 0.29 11.2 0.0 2.1 2 0 0 2 2 2 0 Rhomboid N-terminal domain PPTA PF01239.22 EMC84435.1 - 2.9e-21 74.5 10.0 1.7e-07 30.7 0.2 5.4 5 0 0 5 5 5 4 Protein prenyltransferase alpha subunit repeat YliH PF10799.8 EMC84435.1 - 0.13 12.2 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Biofilm formation protein (YliH/bssR) zf-MYST PF17772.1 EMC84436.1 - 1.4e-20 72.7 0.5 2.1e-20 72.1 0.5 1.3 1 0 0 1 1 1 1 MYST family zinc finger domain MOZ_SAS PF01853.18 EMC84436.1 - 0.0001 22.1 0.0 0.0002 21.1 0.0 1.5 1 0 0 1 1 1 1 MOZ/SAS family Nrap_D3 PF17404.2 EMC84436.1 - 0.074 13.1 0.3 0.12 12.4 0.3 1.3 1 0 0 1 1 1 0 Nrap protein domain 3 PRCC PF10253.9 EMC84437.1 - 2.3e-47 162.5 8.0 2.5e-47 162.4 8.0 1.0 1 0 0 1 1 1 1 Mitotic checkpoint regulator, MAD2B-interacting Tubulin PF00091.25 EMC84438.1 - 1.1e-14 55.1 0.1 1.3e-14 54.8 0.1 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin PF00091.25 EMC84439.1 - 4.8e-69 232.5 0.0 6.4e-69 232.1 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EMC84439.1 - 3.9e-52 175.7 0.0 6.1e-52 175.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EMC84439.1 - 0.0014 18.3 0.0 0.0028 17.4 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin_C PF03953.17 EMC84440.1 - 3.7e-52 175.8 0.0 5.7e-52 175.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 EMC84440.1 - 3.8e-43 148.0 0.1 1.4e-42 146.1 0.1 1.8 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Ras PF00071.22 EMC84441.1 - 7.2e-29 100.5 0.0 8.6e-29 100.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC84441.1 - 5.2e-07 29.9 0.0 1.2e-06 28.7 0.0 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase wnt PF00110.19 EMC84442.1 - 1.8e-111 372.7 2.1 2e-111 372.5 2.1 1.0 1 0 0 1 1 1 1 wnt family PCNP PF15473.6 EMC84442.1 - 0.067 13.9 0.0 0.12 13.1 0.0 1.3 1 0 0 1 1 1 0 PEST, proteolytic signal-containing nuclear protein family Arf PF00025.21 EMC84443.1 - 6.2e-79 263.5 0.1 7.3e-79 263.2 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EMC84443.1 - 6.7e-15 55.0 0.0 8.4e-15 54.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EMC84443.1 - 2e-14 53.8 0.0 2.8e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMC84443.1 - 4.3e-13 49.2 0.0 4.8e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EMC84443.1 - 8.9e-12 44.8 1.4 7.4e-08 31.9 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EMC84443.1 - 5.6e-11 42.2 0.0 6.7e-11 42.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMC84443.1 - 8.4e-06 25.8 0.0 1.3e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EMC84443.1 - 0.0035 16.7 0.6 0.023 14.0 0.1 1.9 2 0 0 2 2 2 1 6-phosphofructo-2-kinase FKBP_C PF00254.28 EMC84444.1 - 5.2e-21 74.8 0.0 7.1e-21 74.3 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase BatD PF13584.6 EMC84444.1 - 0.13 11.1 0.0 0.14 10.9 0.0 1.0 1 0 0 1 1 1 0 Oxygen tolerance NYD-SP28_assoc PF14775.6 EMC84445.1 - 6.4e-06 26.2 3.6 1.1e-05 25.4 3.6 1.4 1 0 0 1 1 1 1 Sperm tail C-terminal domain KfrA_N PF11740.8 EMC84445.1 - 0.0021 18.7 2.2 0.0032 18.1 2.2 1.2 1 0 0 1 1 1 1 Plasmid replication region DNA-binding N-term DivIC PF04977.15 EMC84445.1 - 0.016 14.9 0.9 0.031 14.0 0.9 1.4 1 0 0 1 1 1 0 Septum formation initiator Nmad5 PF18757.1 EMC84445.1 - 0.034 14.4 0.1 0.037 14.2 0.1 1.1 1 0 0 1 1 1 0 Nucleotide modification associated domain 5 DUF1943 PF09172.11 EMC84445.1 - 0.14 11.4 0.1 0.17 11.1 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) DEAD PF00270.29 EMC84446.1 - 4.3e-54 182.9 0.0 2.5e-53 180.4 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC84446.1 - 5.7e-22 78.2 0.0 3.4e-21 75.7 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC84446.1 - 0.0068 16.4 0.3 0.028 14.4 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF3698 PF12479.8 EMC84446.1 - 0.17 12.4 0.9 0.72 10.4 0.9 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3698) Guanylate_kin PF00625.21 EMC84447.1 - 3.2e-28 98.6 0.2 5.7e-27 94.6 0.2 2.1 1 1 0 1 1 1 1 Guanylate kinase VGCC_beta4Aa_N PF12052.8 EMC84447.1 - 1.8e-12 47.1 3.0 3.3e-12 46.3 3.0 1.4 1 0 0 1 1 1 1 Voltage gated calcium channel subunit beta domain 4Aa N terminal DUF1053 PF06327.14 EMC84448.1 - 1.6e-13 51.1 0.8 2.5e-13 50.5 0.8 1.3 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1053) Guanylate_cyc PF00211.20 EMC84448.1 - 4e-08 33.1 0.0 5.8e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain AGP PF06376.12 EMC84448.1 - 0.18 11.6 1.1 7.3 6.5 0.3 2.6 2 0 0 2 2 2 0 Arabinogalactan peptide DuoxA PF10204.9 EMC84448.1 - 0.26 10.3 7.2 0.48 9.4 7.2 1.3 1 0 0 1 1 1 0 Dual oxidase maturation factor SPC25 PF06703.11 EMC84448.1 - 4.1 7.2 7.1 3 7.6 5.3 1.7 1 1 1 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF2207 PF09972.9 EMC84448.1 - 9.3 4.9 7.6 52 2.4 7.6 1.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Cyclin_N PF00134.23 EMC84449.1 - 3e-16 59.3 0.7 7.8e-13 48.3 0.1 2.5 2 0 0 2 2 2 2 Cyclin, N-terminal domain UPF0253 PF06786.12 EMC84449.1 - 0.13 12.6 0.3 0.33 11.2 0.3 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0253) SPAM PF02090.15 EMC84450.1 - 6.1e-05 22.9 16.6 10 5.9 0.1 7.3 8 0 0 8 8 8 6 Salmonella surface presentation of antigen gene type M protein Bax1-I PF01027.20 EMC84451.1 - 6.1e-25 88.3 13.3 8.5e-21 74.7 5.3 2.0 2 0 0 2 2 2 2 Inhibitor of apoptosis-promoting Bax1 ATG101 PF07855.12 EMC84452.1 - 2.3e-42 144.6 0.0 3.1e-42 144.2 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 101 Pkinase PF00069.25 EMC84453.1 - 8.7e-34 117.1 0.0 1.2e-33 116.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC84453.1 - 3e-32 111.9 0.0 4.5e-32 111.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TGF_beta_GS PF08515.12 EMC84453.1 - 3.4e-14 52.0 0.6 6.3e-14 51.2 0.6 1.5 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Activin_recp PF01064.23 EMC84453.1 - 3.3e-07 31.3 10.3 7.3e-07 30.2 10.3 1.6 1 0 0 1 1 1 1 Activin types I and II receptor domain Pkinase_fungal PF17667.1 EMC84453.1 - 5.5e-05 22.1 0.4 0.00018 20.4 0.1 1.8 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EMC84453.1 - 0.006 16.5 0.0 0.013 15.4 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 EMC84453.1 - 0.075 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 EMC84453.1 - 0.1 11.5 0.0 0.19 10.6 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_Tyr PF07714.17 EMC84454.1 - 2.6e-28 99.0 0.0 6e-28 97.8 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC84454.1 - 2.8e-27 95.7 0.0 4.8e-27 95.0 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EMC84454.1 - 0.0005 19.0 0.0 0.00072 18.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMC84454.1 - 0.011 15.7 0.1 0.015 15.2 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EMC84454.1 - 0.1 11.5 0.0 0.19 10.6 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Ank_5 PF13857.6 EMC84456.1 - 3.8e-16 58.9 0.3 1.8e-08 34.4 0.1 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC84456.1 - 1.3e-15 57.7 0.1 1.7e-15 57.3 0.1 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC84456.1 - 1.6e-10 41.3 0.2 3.3e-05 24.4 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC84456.1 - 1e-08 34.7 0.6 9.5e-05 22.5 0.1 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EMC84456.1 - 1.2e-08 35.0 0.3 0.00095 19.5 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat UL41A PF17591.2 EMC84457.1 - 0.028 14.5 1.3 0.028 14.5 1.3 3.9 1 1 2 4 4 4 0 Herpesvirus UL41A Hexapep PF00132.24 EMC84458.1 - 8e-05 22.2 32.7 0.064 13.0 3.9 6.1 3 1 3 6 6 6 6 Bacterial transferase hexapeptide (six repeats) TMEM213 PF15192.6 EMC84458.1 - 3.4 7.7 20.2 49 4.0 0.1 5.6 1 1 3 4 4 4 0 TMEM213 family SLH PF00395.20 EMC84460.1 - 0.0026 17.7 0.7 2.6 8.1 0.0 2.3 1 1 1 2 2 2 2 S-layer homology domain Plasmid_RAQPRD PF09686.10 EMC84460.1 - 0.13 12.5 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Pentapeptide PF00805.22 EMC84461.1 - 9.4e-06 25.2 5.7 2.9e-05 23.6 5.8 1.7 1 1 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 EMC84461.1 - 0.085 13.0 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) SAM_PNT PF02198.16 EMC84461.1 - 0.21 11.6 1.3 3.3 7.8 0.2 2.1 1 1 1 2 2 2 0 Sterile alpha motif (SAM)/Pointed domain Methyltransf_11 PF08241.12 EMC84462.1 - 7.2e-17 61.8 0.0 1.1e-16 61.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC84462.1 - 5.1e-15 55.7 0.0 6.5e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC84462.1 - 5.2e-12 46.3 0.0 9.2e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC84462.1 - 2.3e-11 44.3 0.0 4.2e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMC84462.1 - 9.3e-09 34.9 0.0 1.2e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EMC84462.1 - 7.6e-08 32.3 0.0 1.1e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EMC84462.1 - 0.00059 19.8 0.0 0.00094 19.1 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase MetW PF07021.12 EMC84462.1 - 0.021 14.4 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_24 PF13578.6 EMC84462.1 - 0.17 12.9 0.0 0.46 11.5 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Trypsin PF00089.26 EMC84463.1 - 4e-54 183.8 0.0 4.4e-54 183.6 0.0 1.0 1 0 0 1 1 1 1 Trypsin bZIP_1 PF00170.21 EMC84464.1 - 2.2e-21 75.7 9.0 4e-21 74.9 9.0 1.4 1 0 0 1 1 1 1 bZIP transcription factor pKID PF02173.17 EMC84464.1 - 6.4e-19 67.1 5.0 6.4e-19 67.1 5.0 1.8 2 0 0 2 2 2 1 pKID domain bZIP_2 PF07716.15 EMC84464.1 - 5.7e-09 35.9 8.2 1e-08 35.1 8.2 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EMC84464.1 - 0.00023 21.6 4.9 0.00055 20.4 4.9 1.6 1 0 0 1 1 1 1 bZIP Maf transcription factor ASD2 PF08687.11 EMC84464.1 - 0.018 14.6 1.4 0.018 14.6 1.4 1.5 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Rh5 PF18515.1 EMC84464.1 - 0.029 13.7 1.5 0.039 13.2 1.5 1.2 1 0 0 1 1 1 0 Rh5 coiled-coil domain DUF4988 PF16378.5 EMC84464.1 - 0.13 11.9 1.4 1.7 8.3 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function RHIM PF12721.7 EMC84464.1 - 0.21 12.1 2.6 0.3 11.6 0.5 2.4 2 0 0 2 2 2 0 RIP homotypic interaction motif AMP-binding PF00501.28 EMC84465.1 - 1.3e-76 258.0 0.9 8.8e-67 225.5 0.0 2.4 2 1 0 2 2 2 2 AMP-binding enzyme DMAP_binding PF06464.11 EMC84465.1 - 3.4e-25 89.0 0.1 6.9e-25 88.0 0.1 1.6 1 0 0 1 1 1 1 DMAP1-binding Domain La PF05383.17 EMC84466.1 - 3.2e-18 65.5 0.2 6e-18 64.7 0.2 1.5 1 0 0 1 1 1 1 La domain Claudin_2 PF13903.6 EMC84467.1 - 2.2e-13 50.4 8.2 2.9e-13 50.0 8.2 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 EMC84467.1 - 2e-05 24.5 12.2 3.8e-05 23.6 12.2 1.4 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family DUF1129 PF06570.11 EMC84467.1 - 1.6 8.2 5.5 1.6 8.1 3.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Ocular_alb PF02101.15 EMC84468.1 - 5.1e-203 674.4 7.9 6.1e-203 674.2 7.9 1.0 1 0 0 1 1 1 1 Ocular albinism type 1 protein 7tm_2 PF00002.24 EMC84468.1 - 0.00069 19.0 10.8 0.0012 18.2 10.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (Secretin family) 7tm_1 PF00001.21 EMC84468.1 - 0.2 11.0 11.7 0.35 10.1 11.7 1.4 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) WD40 PF00400.32 EMC84469.1 - 8.8e-53 175.1 27.6 1.8e-10 41.2 0.2 8.5 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC84469.1 - 1.4e-30 105.5 1.7 7.5e-09 35.8 0.0 5.9 3 2 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC84469.1 - 3.5e-11 43.3 0.5 0.0017 18.3 0.1 3.5 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A LisH PF08513.11 EMC84469.1 - 6.2e-10 38.7 0.1 3.7e-09 36.2 0.0 2.2 2 0 0 2 2 2 1 LisH Ge1_WD40 PF16529.5 EMC84469.1 - 1.1e-05 24.5 1.2 0.086 11.8 0.0 3.4 2 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EMC84469.1 - 0.00023 20.6 0.0 1.2 8.4 0.0 3.1 4 1 0 4 4 4 2 WD40-like domain K_channel_TID PF07941.11 EMC84469.1 - 0.018 15.5 3.4 0.035 14.6 3.4 1.4 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Nup160 PF11715.8 EMC84469.1 - 0.022 13.4 4.3 0.27 9.8 0.0 3.6 2 2 3 5 5 5 0 Nucleoporin Nup120/160 PD40 PF07676.12 EMC84469.1 - 0.04 13.9 0.0 0.29 11.1 0.0 2.5 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Glyco_hydro_11 PF00457.17 EMC84469.1 - 0.084 12.5 1.2 2.8 7.5 0.1 2.8 2 0 0 2 2 2 0 Glycosyl hydrolases family 11 IKI3 PF04762.12 EMC84469.1 - 0.089 10.8 0.4 1.3 6.9 0.0 2.4 2 1 1 3 3 3 0 IKI3 family Yae1_N PF09811.9 EMC84470.1 - 1.8e-27 94.7 111.9 1.8e+04 -76.7 111.9 9.7 1 1 0 1 1 1 0 Essential protein Yae1, N terminal fn3 PF00041.21 EMC84472.1 - 9.8e-39 131.6 12.1 5.7e-15 55.4 0.1 4.3 4 0 0 4 4 4 3 Fibronectin type III domain Cys_box PF17869.1 EMC84472.1 - 1.1e-13 51.1 5.9 1.1e-13 51.1 5.9 2.5 2 0 0 2 2 2 1 Anosmin cysteine rich domain WAP PF00095.21 EMC84472.1 - 7.4e-10 39.1 14.9 7.4e-10 39.1 14.9 1.8 2 0 0 2 2 2 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Interfer-bind PF09294.10 EMC84472.1 - 0.00036 20.8 3.6 0.0025 18.1 0.1 3.2 3 0 0 3 3 3 1 Interferon-alpha/beta receptor, fibronectin type III Pur_ac_phosph_N PF16656.5 EMC84472.1 - 0.0021 18.6 6.4 0.27 11.8 0.3 4.3 4 1 0 4 4 4 1 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 EMC84472.1 - 0.022 15.1 0.2 1.1 9.7 0.1 2.9 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2369) DUF4959 PF16323.5 EMC84472.1 - 0.067 13.5 0.0 0.23 11.8 0.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4959) Patatin PF01734.22 EMC84473.1 - 8.4e-08 32.6 0.0 1.1e-07 32.3 0.0 1.2 1 0 0 1 1 1 1 Patatin-like phospholipase Sulfatase PF00884.23 EMC84474.1 - 3.8e-89 299.1 0.0 4.7e-89 298.8 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 EMC84474.1 - 1.7e-43 148.3 0.6 4e-43 147.1 0.6 1.6 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 EMC84474.1 - 8.6e-09 35.4 0.1 0.00024 20.8 0.0 2.1 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4621 PF15414.6 EMC84474.1 - 0.24 10.3 0.0 0.37 9.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4621) HAD_2 PF13419.6 EMC84475.1 - 3.2e-11 43.6 0.0 3.9e-11 43.3 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EMC84475.1 - 1.1e-08 35.7 0.0 1.4e-08 35.3 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EMC84475.1 - 0.063 13.4 0.0 0.33 11.1 0.0 2.0 1 1 1 2 2 2 0 Haloacid dehalogenase-like hydrolase NaeI PF09126.10 EMC84475.1 - 0.094 11.9 0.0 0.13 11.5 0.0 1.1 1 0 0 1 1 1 0 Restriction endonuclease NaeI HAD PF12710.7 EMC84475.1 - 0.11 12.9 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase RVT_1 PF00078.27 EMC84476.1 - 0.026 14.0 0.0 0.065 12.7 0.0 1.7 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) COesterase PF00135.28 EMC84477.1 - 4.9e-198 659.1 0.0 6.1e-198 658.8 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMC84477.1 - 5.2e-07 29.7 0.1 3.5e-06 27.0 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold SCF PF02404.15 EMC84477.1 - 0.14 11.4 0.0 2.8 7.2 0.0 2.2 2 0 0 2 2 2 0 Stem cell factor Pkinase PF00069.25 EMC84479.1 - 4.2e-67 226.3 0.0 4.9e-67 226.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC84479.1 - 2.7e-33 115.4 0.0 3.3e-33 115.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC84479.1 - 7.7e-08 32.0 0.0 1.7e-07 30.8 0.0 1.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EMC84479.1 - 0.0029 17.6 0.0 1.1 9.1 0.0 2.2 2 0 0 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EMC84479.1 - 0.02 13.9 0.1 0.027 13.4 0.1 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 EMC84479.1 - 0.038 12.8 0.0 0.047 12.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase CagZ PF09053.10 EMC84479.1 - 0.18 11.4 0.2 0.4 10.3 0.1 1.5 2 0 0 2 2 2 0 CagZ I-set PF07679.16 EMC84480.1 - 1.2e-159 518.9 0.0 4.4e-16 58.7 0.0 13.1 13 0 0 13 13 13 12 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC84480.1 - 7.5e-152 494.3 26.1 1.4e-13 51.2 0.0 14.2 14 0 0 14 14 13 12 Immunoglobulin domain ig PF00047.25 EMC84480.1 - 2.9e-107 351.0 0.1 1.9e-10 40.8 0.0 13.8 13 0 0 13 13 13 12 Immunoglobulin domain Ig_2 PF13895.6 EMC84480.1 - 2.4e-87 287.3 10.3 5.7e-10 39.4 0.0 13.1 13 0 0 13 13 13 11 Immunoglobulin domain V-set PF07686.17 EMC84480.1 - 1.9e-48 163.2 26.2 0.00072 19.7 0.1 16.5 12 6 0 12 12 12 10 Immunoglobulin V-set domain LRR_8 PF13855.6 EMC84480.1 - 1.8e-29 101.2 16.0 1.3e-11 44.1 1.2 5.2 2 1 3 5 5 5 4 Leucine rich repeat Ig_6 PF18452.1 EMC84480.1 - 3.3e-22 77.8 0.1 0.016 14.7 0.0 11.0 11 0 0 11 11 11 5 Immunoglobulin domain Izumo-Ig PF16706.5 EMC84480.1 - 3.8e-20 71.7 0.4 0.73 9.9 0.0 11.4 11 0 0 11 11 11 4 Izumo-like Immunoglobulin domain LRR_4 PF12799.7 EMC84480.1 - 1.4e-09 38.1 9.6 0.00082 19.7 0.0 4.6 2 1 1 4 4 4 4 Leucine Rich repeats (2 copies) Ig_C17orf99 PF17736.1 EMC84480.1 - 1.7e-08 34.4 0.2 5.6 7.1 0.0 8.4 9 0 0 9 9 9 2 C17orf99 Ig domain Receptor_2B4 PF11465.8 EMC84480.1 - 6.9e-08 32.7 0.0 3.6 7.8 0.0 7.6 8 0 0 8 8 8 1 Natural killer cell receptor 2B4 LRR_5 PF13306.6 EMC84480.1 - 3.9e-07 30.1 0.0 1.8e-06 27.9 0.1 2.1 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) Ig_4 PF16680.5 EMC84480.1 - 3.8e-05 23.9 3.2 15 5.9 0.0 9.0 12 0 0 12 12 11 0 T-cell surface glycoprotein CD3 delta chain LRRNT PF01462.18 EMC84480.1 - 0.017 14.8 3.5 0.055 13.1 3.5 2.0 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain C2-set PF05790.15 EMC84480.1 - 0.023 14.9 1.9 7.6 6.8 0.0 5.4 6 0 0 6 6 4 0 Immunoglobulin C2-set domain AMP-binding_C_2 PF14535.6 EMC84480.1 - 0.072 13.4 0.8 6.1 7.2 0.0 4.0 4 0 0 4 4 4 0 AMP-binding enzyme C-terminal domain Sulfatase PF00884.23 EMC84481.1 - 1.3e-83 280.9 0.0 1.7e-83 280.6 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 EMC84481.1 - 3.7e-47 160.1 0.0 6.3e-47 159.4 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 EMC84481.1 - 1.1e-09 38.4 0.0 0.0012 18.5 0.0 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EMC84482.1 - 4.2e-85 285.8 0.0 8.7e-85 284.8 0.0 1.5 1 1 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 EMC84482.1 - 2.3e-48 164.0 0.1 4e-48 163.2 0.1 1.4 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 EMC84482.1 - 4.8e-09 36.3 0.0 0.00036 20.2 0.0 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.5 EMC84482.1 - 0.028 14.7 0.0 7.5 6.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4976) DUF229 PF02995.17 EMC84482.1 - 0.091 11.4 0.0 0.12 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Glyco_transf_8 PF01501.20 EMC84483.1 - 4.3e-20 72.4 0.0 9.5e-18 64.7 0.0 2.2 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 EMC84483.1 - 0.0034 16.8 0.0 0.0057 16.0 0.0 1.4 1 0 0 1 1 1 1 Mannosyltransferase putative Nucleotid_trans PF03407.16 EMC84483.1 - 0.0047 16.9 0.0 0.0079 16.2 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase CD99L2 PF12301.8 EMC84484.1 - 3.8e-14 53.3 0.3 7.2e-13 49.2 0.2 2.1 1 1 1 2 2 2 2 CD99 antigen like protein 2 CD99L2 PF12301.8 EMC84485.1 - 3.3e-16 60.0 4.1 3.6e-16 59.9 4.1 1.0 1 0 0 1 1 1 1 CD99 antigen like protein 2 ENOD93 PF03386.14 EMC84485.1 - 0.026 14.4 0.2 0.026 14.4 0.2 1.2 1 0 0 1 1 1 0 Early nodulin 93 ENOD93 protein Glycophorin_A PF01102.18 EMC84485.1 - 0.034 14.4 0.1 0.037 14.2 0.1 1.1 1 0 0 1 1 1 0 Glycophorin A zf-BED PF02892.15 EMC84486.1 - 5.1e-16 58.4 1.0 1.3e-15 57.1 1.0 1.8 1 0 0 1 1 1 1 BED zinc finger Dimer_Tnp_hAT PF05699.14 EMC84486.1 - 2.1e-14 53.0 0.1 6.3e-14 51.5 0.1 1.8 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4413 PF14372.6 EMC84486.1 - 8.8e-05 22.8 1.6 0.00032 21.0 0.7 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4413) adh_short PF00106.25 EMC84487.1 - 1.4e-15 57.3 0.5 1e-13 51.2 0.5 2.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC84487.1 - 2.6e-09 37.0 0.0 1.4e-08 34.6 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC84487.1 - 0.008 16.1 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EMC84487.1 - 0.025 14.0 0.1 0.88 8.9 0.0 2.1 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Methyltransf_2 PF00891.18 EMC84488.1 - 2.1e-84 282.0 0.0 2.5e-84 281.8 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 EMC84488.1 - 6.4e-12 45.3 0.1 1.4e-11 44.2 0.1 1.6 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_25 PF13649.6 EMC84488.1 - 2.5e-07 31.3 0.0 6.6e-07 30.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC84488.1 - 2.1e-06 27.7 0.0 3.2e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC84488.1 - 6.6e-05 23.5 0.0 0.00035 21.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC84488.1 - 8.4e-05 22.4 0.0 0.00014 21.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC84488.1 - 0.00035 21.3 0.0 0.00067 20.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EMC84488.1 - 0.0016 18.0 0.0 0.0024 17.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain RrnaAD PF00398.20 EMC84488.1 - 0.013 14.6 0.0 0.019 14.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Sld3_N PF18523.1 EMC84488.1 - 0.097 12.8 0.1 0.25 11.5 0.1 1.6 1 0 0 1 1 1 0 Sld3 N-terminal domain RRM_1 PF00076.22 EMC84489.1 - 0.00099 18.9 0.4 1.4 8.8 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 7tm_1 PF00001.21 EMC84490.1 - 1.3e-43 149.2 25.8 1.7e-43 148.8 25.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 EMC84490.1 - 0.027 13.8 25.6 0.038 13.3 25.6 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv VHS PF00790.19 EMC84490.1 - 0.048 13.5 0.0 0.089 12.6 0.0 1.3 1 0 0 1 1 1 0 VHS domain Methyltransf_2 PF00891.18 EMC84491.1 - 3.3e-61 206.3 0.0 5.1e-61 205.6 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Maf PF02545.14 EMC84491.1 - 9e-45 152.5 0.0 1.5e-44 151.8 0.0 1.4 1 0 0 1 1 1 1 Maf-like protein Dimerisation2 PF16864.5 EMC84491.1 - 2.4e-33 114.0 0.1 8.2e-33 112.3 0.1 2.0 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_25 PF13649.6 EMC84491.1 - 0.00056 20.6 0.0 0.0023 18.6 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC84491.1 - 0.0085 16.8 0.0 0.034 14.9 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain DUF2019 PF09450.10 EMC84491.1 - 0.082 12.9 0.1 1.1 9.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF2019) AAA_assoc_C PF09821.9 EMC84491.1 - 0.096 13.2 0.0 0.23 12.0 0.0 1.7 1 0 0 1 1 1 0 C-terminal AAA-associated domain Mito_carr PF00153.27 EMC84492.1 - 1.7e-56 188.2 2.3 4.3e-23 81.1 0.0 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Fuseless PF15993.5 EMC84492.1 - 0.072 12.3 0.1 0.43 9.7 0.1 1.9 2 0 0 2 2 2 0 Fuseless IL6Ra-bind PF09240.10 EMC84493.1 - 3e-22 78.8 1.3 4.7e-22 78.2 0.3 1.8 2 0 0 2 2 2 1 Interleukin-6 receptor alpha chain, binding IL3Ra_N PF18611.1 EMC84493.1 - 2.2e-08 34.0 5.5 2.2e-07 30.8 0.3 3.0 2 1 0 2 2 2 2 IL-3 receptor alpha chain N-terminal domain EpoR_lig-bind PF09067.10 EMC84493.1 - 0.00025 21.2 2.3 0.0003 21.0 0.4 2.0 2 1 0 2 2 2 1 Erythropoietin receptor, ligand binding IL2RB_N1 PF18707.1 EMC84493.1 - 0.0074 16.8 3.6 1.6 9.3 0.0 3.2 2 2 1 3 3 3 2 Interleukin-2 receptor subunit beta N-terminal domain 1 IL4Ra_N PF09238.10 EMC84493.1 - 0.034 14.5 1.8 0.048 14.0 0.7 1.9 2 0 0 2 2 2 0 Interleukin-4 receptor alpha chain, N-terminal IL6Ra-bind PF09240.10 EMC84495.1 - 3.6e-19 69.0 0.1 8.5e-19 67.8 0.1 1.6 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding EpoR_lig-bind PF09067.10 EMC84495.1 - 0.018 15.3 0.5 0.018 15.3 0.5 1.9 2 0 0 2 2 2 0 Erythropoietin receptor, ligand binding IL2RB_N1 PF18707.1 EMC84495.1 - 0.038 14.5 1.5 0.092 13.3 0.3 2.2 1 1 1 2 2 2 0 Interleukin-2 receptor subunit beta N-terminal domain 1 IL6Ra-bind PF09240.10 EMC84496.1 - 1.5e-19 70.2 0.4 3.1e-19 69.2 0.4 1.5 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding fn3 PF00041.21 EMC84496.1 - 0.04 14.2 0.2 0.29 11.5 0.0 2.3 2 1 0 2 2 2 0 Fibronectin type III domain IL6Ra-bind PF09240.10 EMC84497.1 - 1.1e-11 45.0 0.7 1.8e-11 44.3 0.7 1.4 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding IL12p40_C PF10420.9 EMC84497.1 - 0.00066 20.1 0.8 0.001 19.5 0.8 1.3 1 0 0 1 1 1 1 Cytokine interleukin-12p40 C-terminus Tissue_fac PF01108.17 EMC84498.1 - 0.0061 16.4 1.1 0.14 12.1 0.4 2.5 2 0 0 2 2 2 1 Tissue factor EP400_N PF15790.5 EMC84498.1 - 0.071 11.9 0.2 0.095 11.5 0.2 1.1 1 0 0 1 1 1 0 E1A-binding protein p400, N-terminal AMP-binding PF00501.28 EMC84498.1 - 0.18 10.4 0.0 0.26 9.9 0.0 1.2 1 0 0 1 1 1 0 AMP-binding enzyme Homeodomain PF00046.29 EMC84500.1 - 4.2e-25 87.3 2.9 7e-25 86.7 2.9 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC84500.1 - 0.00021 21.1 1.3 0.00071 19.4 0.0 2.4 3 0 0 3 3 3 1 Homeobox KN domain MRP-L20 PF12824.7 EMC84500.1 - 0.0053 16.9 0.5 0.01 16.0 0.5 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 EF-hand_13 PF17958.1 EMC84501.1 - 2.9e-43 145.6 0.0 3.1e-41 139.1 0.0 2.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 EMC84501.1 - 2.5e-22 79.1 6.9 1.1e-20 73.8 2.2 4.0 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 EMC84501.1 - 1.7e-08 33.4 0.2 0.073 12.7 0.0 5.9 6 0 0 6 6 6 2 EF hand EF-hand_6 PF13405.6 EMC84501.1 - 1.9e-07 30.4 0.6 0.034 14.1 0.0 5.7 6 0 0 6 6 6 1 EF-hand domain EF-hand_8 PF13833.6 EMC84501.1 - 5.6e-07 29.3 0.3 0.46 10.4 0.0 6.1 6 0 0 6 6 6 1 EF-hand domain pair EF-hand_5 PF13202.6 EMC84501.1 - 2e-06 27.0 0.1 0.0005 19.4 0.0 4.0 5 0 0 5 5 5 1 EF hand SPARC_Ca_bdg PF10591.9 EMC84501.1 - 0.059 13.7 5.1 2.8 8.3 0.3 3.1 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region STAG PF08514.11 EMC84503.1 - 9.5e-34 115.7 0.2 9.5e-34 115.7 0.2 2.2 2 0 0 2 2 2 1 STAG domain HEAT PF02985.22 EMC84503.1 - 0.068 13.5 0.0 47 4.6 0.0 4.0 3 0 0 3 3 3 0 HEAT repeat AHSP PF09236.10 EMC84503.1 - 0.19 12.2 4.8 2.5 8.6 0.1 3.4 3 0 0 3 3 3 0 Alpha-haemoglobin stabilising protein GTP-bdg_M PF16360.5 EMC84504.1 - 2.3e-21 76.2 6.1 5.1e-21 75.1 6.1 1.6 1 0 0 1 1 1 1 GTP-binding GTPase Middle Region GTP-bdg_N PF13167.6 EMC84504.1 - 4.8e-15 56.0 0.9 1.3e-13 51.4 0.1 2.8 2 0 0 2 2 2 1 GTP-binding GTPase N-terminal MMR_HSR1 PF01926.23 EMC84504.1 - 2.8e-13 50.0 0.0 9.1e-13 48.3 0.0 1.9 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EMC84504.1 - 0.00043 19.8 0.7 0.0017 17.9 0.7 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B Rad17 PF03215.15 EMC84504.1 - 0.00063 19.7 0.4 0.36 10.7 0.0 2.5 2 0 0 2 2 2 2 Rad17 P-loop domain RsgA_GTPase PF03193.16 EMC84504.1 - 0.002 18.0 0.4 3 7.7 0.0 2.9 3 0 0 3 3 3 2 RsgA GTPase PduV-EutP PF10662.9 EMC84504.1 - 0.0025 17.6 0.3 0.046 13.5 0.0 2.6 3 0 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.27 EMC84504.1 - 0.0099 15.4 0.1 4.8 6.7 0.1 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 EMC84504.1 - 0.021 14.8 0.0 0.089 12.8 0.0 2.0 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain ABC_tran PF00005.27 EMC84504.1 - 0.033 14.7 0.6 0.073 13.6 0.2 2.0 1 1 1 2 2 2 0 ABC transporter MnmE_helical PF12631.7 EMC84504.1 - 0.037 14.2 0.0 0.088 13.0 0.0 1.5 1 1 0 1 1 1 0 MnmE helical domain TniB PF05621.11 EMC84504.1 - 0.041 13.3 0.0 0.095 12.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein MobB PF03205.14 EMC84504.1 - 0.073 13.0 0.1 0.24 11.3 0.0 2.0 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.6 EMC84504.1 - 0.08 13.3 0.1 0.17 12.3 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain DLIC PF05783.11 EMC84504.1 - 0.082 11.7 0.0 0.11 11.3 0.0 1.3 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Dynamin_N PF00350.23 EMC84504.1 - 0.089 12.8 0.1 0.4 10.7 0.0 2.1 2 1 1 3 3 3 0 Dynamin family AAA_14 PF13173.6 EMC84504.1 - 0.093 12.8 0.0 0.34 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain SGL PF08450.12 EMC84505.1 - 3.3e-80 269.2 0.0 3.8e-80 269.0 0.0 1.0 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region SGL PF08450.12 EMC84506.1 - 1.5e-78 263.8 0.1 1.7e-78 263.6 0.1 1.0 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Reg_prop PF07494.11 EMC84506.1 - 0.02 15.1 0.0 0.33 11.3 0.0 3.0 2 1 1 3 3 3 0 Two component regulator propeller NHL PF01436.21 EMC84506.1 - 0.095 12.8 0.0 0.27 11.3 0.0 1.8 1 0 0 1 1 1 0 NHL repeat zf-HC5HC2H_2 PF13832.6 EMC84507.1 - 5.5e-30 103.8 7.9 5.5e-30 103.8 7.9 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EMC84507.1 - 6.3e-25 87.3 6.1 6.3e-25 87.3 6.1 3.3 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 EMC84507.1 - 3.1e-12 45.8 7.0 3.1e-12 45.8 7.0 3.6 4 0 0 4 4 4 1 PHD-finger PHD PF00628.29 EMC84507.1 - 2.4e-10 40.1 9.6 2.4e-10 40.1 9.6 3.5 2 1 0 3 3 3 2 PHD-finger EPL1 PF10513.9 EMC84507.1 - 2.8e-10 40.8 0.8 2.8e-10 40.8 0.8 2.9 3 1 0 3 3 3 1 Enhancer of polycomb-like C1_1 PF00130.22 EMC84507.1 - 0.0014 18.4 2.5 0.0014 18.4 2.5 3.8 2 1 1 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 EMC84507.1 - 0.013 15.4 7.5 0.013 15.4 7.5 3.0 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-PHD-like PF15446.6 EMC84507.1 - 0.24 11.0 15.1 5 6.7 7.4 3.5 2 1 0 2 2 2 0 PHD/FYVE-zinc-finger like domain C1_2 PF03107.16 EMC84507.1 - 0.66 10.3 23.8 1.4 9.3 7.9 3.7 3 0 0 3 3 3 0 C1 domain TBCC PF07986.12 EMC84508.1 - 4.3e-46 155.6 5.3 6.4e-46 155.0 5.3 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C NDK PF00334.19 EMC84508.1 - 0.0001 22.3 0.0 0.00021 21.3 0.0 1.4 1 0 0 1 1 1 1 Nucleoside diphosphate kinase CAP_C PF08603.11 EMC84508.1 - 0.00058 19.5 2.7 0.0011 18.7 2.7 1.4 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TMEM51 PF15345.6 EMC84509.1 - 0.0059 16.5 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 Transmembrane protein 51 WRNPLPNID PF15017.6 EMC84509.1 - 0.012 16.5 0.6 0.024 15.5 0.6 1.5 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box COX17 PF05051.13 EMC84509.1 - 0.031 14.6 1.5 0.12 12.8 1.5 2.0 1 0 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) WRNPLPNID PF15017.6 EMC84510.1 - 0.016 16.1 0.3 0.032 15.1 0.3 1.5 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box COX17 PF05051.13 EMC84510.1 - 0.036 14.4 1.5 0.12 12.8 1.5 1.8 1 0 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) TMEM51 PF15345.6 EMC84510.1 - 0.055 13.3 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 GCP_C_terminal PF04130.13 EMC84511.1 - 4.5e-41 141.3 10.8 5.4e-41 141.0 9.3 1.9 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EMC84511.1 - 4.7e-27 95.4 2.2 4.7e-27 95.4 2.2 1.7 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP5-Mod21 PF14609.6 EMC84511.1 - 0.00034 19.1 3.1 0.00041 18.8 0.2 2.4 3 0 0 3 3 3 1 gamma-Tubulin ring complex non-core subunit mod21 DUF5601 PF18151.1 EMC84511.1 - 0.028 14.7 0.7 0.77 10.1 0.1 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5601) fn3 PF00041.21 EMC84512.1 - 0.00037 20.8 0.7 0.00057 20.2 0.0 1.6 2 0 0 2 2 2 1 Fibronectin type III domain FAM163 PF15069.6 EMC84512.1 - 0.012 16.1 0.0 0.024 15.1 0.0 1.5 1 0 0 1 1 1 0 FAM163 family Herpes_gE PF02480.16 EMC84512.1 - 0.032 13.0 0.0 0.044 12.5 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Pur_ac_phosph_N PF16656.5 EMC84512.1 - 0.068 13.7 0.0 0.13 12.8 0.0 1.4 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain MLANA PF14991.6 EMC84512.1 - 0.12 12.7 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein melan-A DUF2207 PF09972.9 EMC84512.1 - 0.2 10.4 0.0 0.25 10.1 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Mg_trans_NIPA PF05653.14 EMC84513.1 - 3.3e-147 489.3 15.5 3.8e-147 489.1 15.5 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EMC84513.1 - 3.2e-09 37.1 4.0 3.2e-09 37.1 4.0 4.2 3 1 0 3 3 3 1 EamA-like transporter family DUF2627 PF11118.8 EMC84513.1 - 0.66 10.6 3.9 13 6.4 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) S1FA PF04689.13 EMC84513.1 - 3.1 8.0 4.9 2 8.6 0.6 2.7 3 0 0 3 3 3 0 DNA binding protein S1FA Mg_trans_NIPA PF05653.14 EMC84514.1 - 2.3e-77 260.0 15.9 2.6e-77 259.9 15.9 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EMC84514.1 - 0.00056 20.1 4.9 0.00056 20.1 4.9 3.2 2 1 0 2 2 2 1 EamA-like transporter family DUF3611 PF12263.8 EMC84514.1 - 0.053 13.4 0.2 0.053 13.4 0.2 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3611) RCC1 PF00415.18 EMC84515.1 - 2.2e-225 729.4 85.7 2.8e-15 56.7 0.1 21.4 21 0 0 21 21 21 19 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EMC84515.1 - 1.2e-90 295.8 112.0 9.2e-08 31.7 0.3 21.8 22 0 0 22 22 22 16 Regulator of chromosome condensation (RCC1) repeat HECT PF00632.25 EMC84515.1 - 9.4e-60 202.7 0.0 1.7e-59 201.8 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Cul7 PF11515.8 EMC84515.1 - 7.4e-35 119.1 2.7 8.4e-35 118.9 0.8 2.1 2 0 0 2 2 2 1 Mouse development and cellular proliferation protein Cullin-7 MIB_HERC2 PF06701.13 EMC84515.1 - 5.6e-22 77.8 5.0 5.6e-22 77.8 5.0 5.6 7 0 0 7 7 7 1 Mib_herc2 Cyt-b5 PF00173.28 EMC84515.1 - 3.9e-10 39.7 0.0 1.5e-09 37.9 0.0 2.0 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain ZZ PF00569.17 EMC84515.1 - 9e-10 38.2 7.0 2.2e-09 37.0 7.0 1.7 1 0 0 1 1 1 1 Zinc finger, ZZ type SH3_15 PF18346.1 EMC84515.1 - 3.1e-06 27.4 5.0 0.00014 22.1 0.6 3.7 3 0 0 3 3 3 1 Mind bomb SH3 repeat domain ANAPC10 PF03256.16 EMC84515.1 - 8e-06 25.6 0.0 1.6e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) Hira PF07569.11 EMC84515.1 - 0.0053 16.5 0.2 67 3.1 0.0 5.9 6 0 0 6 6 6 0 TUP1-like enhancer of split Ubie_methyltran PF01209.18 EMC84515.1 - 0.1 11.9 0.7 21 4.4 0.0 3.7 4 0 0 4 4 4 0 ubiE/COQ5 methyltransferase family Med3 PF11593.8 EMC84515.1 - 0.34 10.1 3.6 0.9 8.7 3.6 1.7 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal zf-UBR PF02207.20 EMC84515.1 - 0.46 10.7 5.3 0.22 11.7 2.2 2.1 2 0 0 2 2 1 0 Putative zinc finger in N-recognin (UBR box) CitMHS PF03600.16 EMC84516.1 - 5.7e-57 193.2 17.5 5.7e-57 193.2 17.5 1.9 1 1 1 2 2 2 1 Citrate transporter Na_sulph_symp PF00939.19 EMC84516.1 - 6.4e-16 58.4 28.2 4.4e-11 42.5 10.1 2.5 2 1 0 2 2 2 2 Sodium:sulfate symporter transmembrane region ArsB PF02040.15 EMC84516.1 - 4.8e-09 36.0 22.3 9.9e-05 21.8 3.6 2.1 2 0 0 2 2 2 2 Arsenical pump membrane protein DUF1673 PF07895.11 EMC84516.1 - 0.3 10.8 0.0 0.3 10.8 0.0 3.3 3 2 1 4 4 4 0 Protein of unknown function (DUF1673) MatC_N PF07158.11 EMC84516.1 - 1.7 8.7 23.9 0.014 15.4 11.8 2.6 2 0 0 2 2 2 0 Dicarboxylate carrier protein MatC N-terminus Neur_chan_memb PF02932.16 EMC84517.1 - 8.8e-38 130.7 12.2 8.1e-35 121.0 7.0 2.1 1 1 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region DUF2070 PF09843.9 EMC84517.1 - 0.44 8.8 2.7 0.52 8.5 2.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Neur_chan_LBD PF02931.23 EMC84518.1 - 3.6e-49 167.1 0.0 5.1e-49 166.7 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC84518.1 - 9.9e-39 133.8 4.4 1.7e-32 113.4 2.8 2.2 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region CytochromB561_N PF09786.9 EMC84518.1 - 0.00063 18.9 1.3 0.00086 18.4 1.3 1.1 1 0 0 1 1 1 1 Cytochrome B561, N terminal Neur_chan_memb PF02932.16 EMC84519.1 - 8.2e-51 173.4 0.3 1.7e-50 172.4 0.3 1.5 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 EMC84519.1 - 3.3e-44 150.9 0.0 4.8e-44 150.4 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain OAD_gamma PF04277.13 EMC84519.1 - 0.16 12.6 0.1 0.4 11.3 0.0 1.7 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain HECT PF00632.25 EMC84520.1 - 3.6e-86 289.4 0.1 7.8e-86 288.3 0.1 1.6 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) AZUL PF16558.5 EMC84520.1 - 5.5e-18 65.0 3.5 1.4e-17 63.6 3.5 1.8 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A LPD11 PF18824.1 EMC84520.1 - 0.019 15.0 0.0 9.5 6.4 0.0 3.1 3 0 0 3 3 3 0 Large polyvalent protein-associated domain 11 Ion_trans PF00520.31 EMC84521.1 - 5.7e-30 104.3 8.6 8.3e-30 103.8 8.6 1.2 1 0 0 1 1 1 1 Ion transport protein CLZ PF16526.5 EMC84521.1 - 7.7e-30 103.1 6.0 7.7e-30 103.1 6.0 2.9 2 1 0 2 2 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels cNMP_binding PF00027.29 EMC84521.1 - 7.5e-19 67.6 0.0 1.3e-18 66.8 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain AAA_23 PF13476.6 EMC84521.1 - 0.00012 22.7 13.8 0.0049 17.4 7.5 2.5 2 0 0 2 2 2 2 AAA domain Adaptin_binding PF10199.9 EMC84521.1 - 0.00021 21.9 4.4 0.0019 18.8 1.1 2.5 2 0 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 Med19 PF10278.9 EMC84521.1 - 0.0031 17.5 13.9 0.0068 16.4 13.9 1.5 1 0 0 1 1 1 1 Mediator of RNA pol II transcription subunit 19 CPSF100_C PF13299.6 EMC84521.1 - 0.0052 17.0 4.4 0.0052 17.0 4.4 1.9 2 0 0 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 EMC84521.1 - 0.0055 15.5 0.8 0.0091 14.8 0.8 1.3 1 0 0 1 1 1 1 Presenilin RR_TM4-6 PF06459.12 EMC84521.1 - 0.0079 16.1 11.1 0.0079 16.1 11.1 1.9 2 0 0 2 2 2 1 Ryanodine Receptor TM 4-6 DDHD PF02862.17 EMC84521.1 - 0.012 15.8 1.0 0.015 15.5 0.0 1.7 2 0 0 2 2 1 0 DDHD domain NPR3 PF03666.13 EMC84521.1 - 0.015 14.1 5.6 0.025 13.4 5.6 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ion_trans_2 PF07885.16 EMC84521.1 - 0.02 14.8 3.4 0.066 13.2 3.4 2.0 1 0 0 1 1 1 0 Ion channel Zip PF02535.22 EMC84521.1 - 0.031 13.5 0.1 0.048 12.9 0.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF913 PF06025.12 EMC84521.1 - 0.038 13.0 1.6 0.072 12.1 1.6 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RNA_pol_Rpc4 PF05132.14 EMC84521.1 - 0.041 14.3 10.0 0.1 13.0 10.0 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 CDC45 PF02724.14 EMC84521.1 - 0.043 12.1 12.9 0.0074 14.6 6.4 2.1 2 0 0 2 2 2 0 CDC45-like protein DUF948 PF06103.11 EMC84521.1 - 0.072 13.4 0.5 6.4 7.1 0.0 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) SpoIIP PF07454.11 EMC84521.1 - 0.083 12.3 13.4 0.18 11.2 13.4 1.5 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF2828 PF11443.8 EMC84521.1 - 0.15 10.1 8.5 0.24 9.4 8.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Tim54 PF11711.8 EMC84521.1 - 0.16 10.7 12.7 0.3 9.8 12.7 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 FAM76 PF16046.5 EMC84521.1 - 0.22 10.8 21.1 0.097 12.0 0.4 2.3 2 0 0 2 2 2 0 FAM76 protein BSMAP PF12280.8 EMC84521.1 - 0.32 11.2 1.9 0.87 9.8 1.9 1.7 1 0 0 1 1 1 0 Brain specific membrane anchored protein NARP1 PF12569.8 EMC84521.1 - 0.43 9.4 25.5 0.0078 15.2 15.7 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 CSRNP_N PF16019.5 EMC84521.1 - 0.68 9.8 6.4 1.7 8.5 6.4 1.6 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Neur_chan_memb PF02932.16 EMC84521.1 - 0.69 9.9 3.4 3.3 7.7 2.4 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Coilin_N PF15862.5 EMC84521.1 - 0.93 9.3 22.6 0.16 11.7 18.0 2.1 2 0 0 2 2 2 0 Coilin N-terminus TMEM214 PF10151.9 EMC84521.1 - 0.97 7.8 15.0 1.7 7.0 15.0 1.3 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator TRAP_alpha PF03896.16 EMC84521.1 - 2.5 7.2 10.7 4.7 6.3 10.7 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF4820 PF16091.5 EMC84521.1 - 2.7 7.3 8.3 6.2 6.1 8.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Amidinotransf PF02274.17 EMC84521.1 - 2.7 7.0 9.5 3.3 6.7 5.7 2.1 2 0 0 2 2 2 0 Amidinotransferase DUF1980 PF09323.10 EMC84521.1 - 3.2 7.6 6.7 15 5.5 6.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) PPL5 PF18168.1 EMC84521.1 - 3.3 6.9 10.1 6.4 6.0 10.1 1.4 1 0 0 1 1 1 0 Prim-pol family 5 AAA_11 PF13086.6 EMC84521.1 - 8.5 6.1 13.5 0.98 9.2 7.0 2.2 2 0 0 2 2 2 0 AAA domain RP-C_C PF11800.8 EMC84521.1 - 8.8 6.4 7.4 0.86 9.7 1.6 2.1 2 0 0 2 2 2 0 Replication protein C C-terminal region Pal1 PF08316.11 EMC84521.1 - 10 6.9 6.7 21 5.9 6.7 1.5 1 0 0 1 1 1 0 Pal1 cell morphology protein VWA_3 PF13768.6 EMC84522.1 - 0.003 17.5 0.2 0.0045 16.9 0.2 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain TMEM131_like PF12371.8 EMC84523.1 - 2.3e-23 82.2 0.8 2.3e-23 82.2 0.8 4.7 5 0 0 5 5 5 2 Transmembrane protein 131-like ASH PF15780.5 EMC84523.1 - 2.2e-10 40.6 6.7 0.00095 19.3 0.2 7.3 7 0 0 7 7 7 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin fn3_5 PF06280.12 EMC84523.1 - 0.11 13.2 3.0 0.41 11.3 0.7 3.3 3 0 0 3 3 3 0 Fn3-like domain C2 PF00168.30 EMC84524.1 - 0.0022 18.3 0.0 0.0051 17.1 0.0 1.6 1 0 0 1 1 1 1 C2 domain NHR2 PF08788.11 EMC84524.1 - 0.0065 16.2 0.5 0.21 11.4 0.2 2.7 2 0 0 2 2 2 1 NHR2 domain like Pet191_N PF10203.9 EMC84525.1 - 7.5e-20 71.0 5.6 9.1e-20 70.7 5.6 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 CHCH PF06747.13 EMC84525.1 - 0.12 12.6 3.7 4.3 7.6 0.7 2.4 2 1 0 2 2 2 0 CHCH domain UNC-50 PF05216.13 EMC84526.1 - 4.5e-91 304.3 22.9 5.2e-91 304.1 22.9 1.0 1 0 0 1 1 1 1 UNC-50 family Glyco_transf_54 PF04666.13 EMC84527.1 - 7.2e-136 451.7 1.5 1e-135 451.3 1.5 1.1 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region DUF4750 PF15938.5 EMC84527.1 - 0.27 10.9 1.4 0.65 9.7 1.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4750) DUF4592 PF15262.6 EMC84528.1 - 2.9e-31 108.9 3.1 2.9e-31 108.9 3.1 3.1 3 2 0 3 3 3 1 Domain of unknown function (DUF4592) RVT_1 PF00078.27 EMC84529.1 - 0.12 11.9 0.0 0.4 10.1 0.0 1.7 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) SH2 PF00017.24 EMC84530.1 - 1.1e-15 57.5 0.2 1.8e-15 56.8 0.2 1.4 1 0 0 1 1 1 1 SH2 domain SIT PF15330.6 EMC84531.1 - 2.4e-29 102.1 1.1 2.4e-29 102.1 1.1 1.5 2 0 0 2 2 2 1 SHP2-interacting transmembrane adaptor protein, SIT EF-hand_1 PF00036.32 EMC84532.1 - 2.2e-23 80.0 10.7 1.5e-06 27.3 1.1 4.7 4 1 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EMC84532.1 - 7.7e-22 75.3 8.9 2.8e-06 26.8 0.9 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 EMC84532.1 - 1.3e-19 70.4 5.0 1e-13 51.5 0.2 3.1 2 2 2 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 EMC84532.1 - 1e-16 59.6 12.6 3.4e-05 23.1 0.2 4.9 4 1 1 5 5 5 3 EF hand EF-hand_8 PF13833.6 EMC84532.1 - 4.8e-12 45.5 8.2 3.9e-07 29.8 0.5 3.4 2 2 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EMC84532.1 - 5e-06 26.8 0.6 0.00032 21.0 0.1 2.8 1 1 1 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EMC84532.1 - 0.00019 21.3 6.8 0.074 13.0 0.7 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 EMC84532.1 - 0.00037 20.6 0.5 0.24 11.6 0.0 2.5 1 1 1 2 2 2 2 Dockerin type I domain EF-hand_10 PF14788.6 EMC84532.1 - 0.016 15.0 0.1 1 9.2 0.0 2.7 2 0 0 2 2 2 0 EF hand DUF4891 PF16232.5 EMC84532.1 - 0.074 13.6 0.0 3.7 8.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4891) Caleosin PF05042.13 EMC84532.1 - 0.085 12.8 3.1 4.1 7.3 0.1 3.0 1 1 2 3 3 3 0 Caleosin related protein B PF02216.16 EMC84534.1 - 0.021 14.8 0.0 0.16 12.0 0.0 2.2 1 1 0 1 1 1 0 B domain C2-set_2 PF08205.12 EMC84535.1 - 1.3e-12 47.6 0.1 3.4e-12 46.3 0.0 1.7 2 1 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 EMC84535.1 - 1.5e-11 44.7 0.2 8.2e-08 32.7 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 EMC84535.1 - 3.2e-10 40.2 0.2 7.6e-05 23.0 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 EMC84535.1 - 1.5e-08 34.7 0.1 2.4e-05 24.4 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC84535.1 - 0.00025 21.0 0.1 0.056 13.5 0.1 2.6 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_6 PF18452.1 EMC84535.1 - 0.017 14.7 0.0 0.034 13.7 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 EMC84536.1 - 5e-08 33.1 0.0 0.0004 20.5 0.1 2.1 2 0 0 2 2 2 2 Immunoglobulin V-set domain Opiods_neuropep PF01160.18 EMC84537.1 - 0.16 12.1 0.1 0.29 11.3 0.1 1.4 1 0 0 1 1 1 0 Vertebrate endogenous opioids neuropeptide Hydrolase_4 PF12146.8 EMC84538.1 - 2.8e-12 46.4 0.1 6.5e-09 35.4 0.0 2.1 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMC84538.1 - 4e-12 46.3 0.2 3.9e-11 43.1 0.1 2.0 1 1 1 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EMC84538.1 - 5.3e-10 39.1 0.0 7.6e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EMC84538.1 - 8.7e-09 36.3 0.0 2.3e-08 34.9 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF2920 PF11144.8 EMC84538.1 - 0.0024 17.1 0.0 0.013 14.6 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF2920) Abhydrolase_2 PF02230.16 EMC84538.1 - 0.02 14.7 0.0 2.3 8.0 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Esterase PF00756.20 EMC84538.1 - 0.024 14.3 0.1 0.065 12.9 0.1 1.8 1 1 0 1 1 1 0 Putative esterase UPF0227 PF05728.12 EMC84538.1 - 0.039 13.9 0.0 0.14 12.1 0.0 2.2 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0227) BAAT_C PF08840.11 EMC84538.1 - 0.057 13.3 0.0 0.087 12.7 0.0 1.2 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Ser_hydrolase PF06821.13 EMC84538.1 - 0.064 13.1 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase Peptidase_S15 PF02129.18 EMC84538.1 - 0.12 11.9 0.1 0.94 9.0 0.1 2.2 2 1 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) CH PF00307.31 EMC84539.1 - 1.5e-21 76.6 0.0 2.2e-21 76.1 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain Calponin PF00402.18 EMC84539.1 - 2.4e-14 52.6 6.4 2.4e-14 52.6 6.4 1.8 2 0 0 2 2 2 1 Calponin family repeat Trypsin PF00089.26 EMC84540.1 - 5.3e-65 219.3 0.4 1.1e-64 218.3 0.4 1.6 1 0 0 1 1 1 1 Trypsin Ldl_recept_a PF00057.18 EMC84540.1 - 1.7e-22 79.4 38.3 1.1e-09 38.4 6.0 3.8 2 1 1 3 3 3 3 Low-density lipoprotein receptor domain class A SEA PF01390.20 EMC84540.1 - 5.2e-20 71.5 0.6 9.7e-20 70.7 0.6 1.4 1 0 0 1 1 1 1 SEA domain CUB PF00431.20 EMC84540.1 - 8.2e-13 48.7 0.3 3.3e-05 24.2 0.2 2.9 2 1 0 2 2 2 2 CUB domain DUF1986 PF09342.11 EMC84540.1 - 0.00062 20.1 0.1 0.0023 18.3 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin PF00089.26 EMC84541.1 - 1.4e-74 250.6 0.1 1.6e-74 250.5 0.1 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 EMC84541.1 - 2.3e-05 24.7 0.1 5.4e-05 23.5 0.1 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) DUF316 PF03761.15 EMC84541.1 - 0.00041 20.0 0.0 0.023 14.2 0.0 2.1 1 1 0 1 1 1 1 Chymotrypsin family Peptidase-S1 Trypsin_2 PF13365.6 EMC84541.1 - 0.0029 18.5 0.0 0.0049 17.8 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Ig_3 PF13927.6 EMC84542.1 - 1.3e-13 51.4 1.3 1.2e-06 29.0 0.2 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 EMC84542.1 - 9.1e-13 48.2 2.4 2.4e-09 37.2 0.7 2.5 2 1 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 EMC84542.1 - 1.2e-10 41.2 0.9 3e-08 33.6 0.1 2.2 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain I-set PF07679.16 EMC84542.1 - 2.8e-10 40.1 1.0 5.5e-05 23.2 0.4 2.5 2 1 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 EMC84542.1 - 1.7e-09 37.8 1.0 2.9e-09 37.1 0.3 1.7 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.6 EMC84542.1 - 1.2e-07 32.0 1.3 0.0099 16.2 0.2 2.5 1 1 0 2 2 2 2 Immunoglobulin domain C1-set PF07654.15 EMC84542.1 - 0.0068 16.8 1.8 0.16 12.3 0.2 2.4 2 0 0 2 2 2 1 Immunoglobulin C1-set domain V-set PF07686.17 EMC84543.1 - 9.2e-10 38.7 0.0 1.1e-09 38.4 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 EMC84543.1 - 1.2e-05 25.4 0.0 2.7e-05 24.3 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC84543.1 - 8.5e-05 22.5 0.0 0.00011 22.2 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC84543.1 - 0.00011 22.8 0.0 0.00017 22.2 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain Izumo-Ig PF16706.5 EMC84543.1 - 0.085 12.9 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain ig PF00047.25 EMC84544.1 - 5.1e-16 58.6 3.0 7.9e-13 48.4 0.6 2.2 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC84544.1 - 6.5e-14 51.8 0.2 4e-07 30.0 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC84544.1 - 9.9e-14 51.7 3.8 3.8e-08 33.8 0.6 2.4 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 EMC84544.1 - 3.5e-13 49.7 0.8 5.3e-13 49.1 0.3 1.5 2 0 0 2 2 2 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC84544.1 - 5.5e-05 23.2 1.8 0.03 14.4 0.1 2.3 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 EMC84544.1 - 0.0012 19.2 8.6 0.015 15.7 3.3 2.8 2 2 0 2 2 2 1 Immunoglobulin domain CD34_antigen PF06365.12 EMC84544.1 - 0.0028 17.3 0.6 0.0045 16.6 0.1 1.6 2 0 0 2 2 2 1 CD34/Podocalyxin family Lep_receptor_Ig PF06328.11 EMC84544.1 - 0.015 15.3 1.6 0.31 11.0 0.1 2.3 2 0 0 2 2 2 0 Ig-like C2-type domain Ig_6 PF18452.1 EMC84544.1 - 0.044 13.3 0.0 0.13 11.8 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin domain NS3_envE PF02723.14 EMC84544.1 - 0.24 11.5 2.7 18 5.5 0.0 2.4 2 0 0 2 2 2 0 Non-structural protein NS3/Small envelope protein E Ig_4 PF16680.5 EMC84544.1 - 0.29 11.4 1.8 10 6.5 0.2 2.6 1 1 1 2 2 2 0 T-cell surface glycoprotein CD3 delta chain Holin_BlyA PF05102.12 EMC84544.1 - 0.55 10.2 3.3 1.3 9.0 3.3 1.5 1 0 0 1 1 1 0 holin, BlyA family AF-4 PF05110.13 EMC84545.1 - 0.12 10.5 48.3 0.13 10.3 48.3 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Saf_2TM PF18303.1 EMC84546.1 - 0.09 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain AKAP95 PF04988.12 EMC84547.1 - 0.00013 22.3 0.6 0.00018 21.8 0.6 1.4 1 0 0 1 1 1 1 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_2 PF12756.7 EMC84547.1 - 0.0034 17.7 1.8 0.0044 17.3 1.1 1.5 1 1 0 1 1 1 1 C2H2 type zinc-finger (2 copies) Mut7-C PF01927.16 EMC84547.1 - 0.011 15.8 1.6 0.36 10.9 0.2 2.2 1 1 1 2 2 2 0 Mut7-C RNAse domain HV_small_capsid PF17086.5 EMC84547.1 - 0.06 13.6 0.1 0.19 12.0 0.0 1.8 1 1 1 2 2 2 0 Small capsid protein of Herpesviridae ADD_ATRX PF17981.1 EMC84547.1 - 0.14 12.1 0.1 0.14 12.1 0.1 1.7 2 0 0 2 2 2 0 Cysteine Rich ADD domain zf-C2H2_12 PF18658.1 EMC84547.1 - 0.23 11.1 1.4 0.37 10.4 0.2 1.9 2 1 1 3 3 3 0 Zinc-finger C2H2-type zf-met PF12874.7 EMC84547.1 - 2 8.9 6.0 38 4.9 6.0 2.5 1 1 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 EMC84549.1 - 4.7e-08 33.1 39.3 0.022 15.2 1.9 6.4 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC84549.1 - 6.4e-06 26.6 42.4 0.026 15.3 2.6 7.3 7 0 0 7 7 7 4 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EMC84549.1 - 0.0092 16.3 5.4 0.0092 16.3 5.4 4.5 3 1 1 4 4 4 2 C2H2-type zinc ribbon Yippee-Mis18 PF03226.14 EMC84549.1 - 0.12 12.6 4.9 6.4 7.1 1.4 3.1 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF1178 PF06676.11 EMC84549.1 - 0.23 11.9 7.0 2.4 8.6 0.5 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1178) zf-met PF12874.7 EMC84549.1 - 2.1 8.9 15.6 0.52 10.8 0.6 4.1 4 0 0 4 4 4 0 Zinc-finger of C2H2 type SPX PF03105.19 EMC84549.1 - 2.6 7.9 17.9 0.056 13.4 2.2 2.2 2 0 0 2 2 2 0 SPX domain DUF4518 PF15008.6 EMC84550.1 - 7.2e-99 330.4 0.1 8.2e-99 330.2 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4518) QLQ PF08880.11 EMC84550.1 - 0.57 10.0 0.1 0.57 10.0 0.1 2.0 2 0 0 2 2 2 0 QLQ Pkinase_Tyr PF07714.17 EMC84551.1 - 3e-98 328.2 0.0 4.3e-98 327.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.19 EMC84551.1 - 1.9e-64 217.0 0.2 4.4e-64 215.8 0.2 1.7 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.25 EMC84551.1 - 4.3e-48 164.0 0.0 7.3e-48 163.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 EMC84551.1 - 3.9e-35 120.1 0.6 1.8e-16 60.2 0.5 3.1 2 0 0 2 2 2 2 Fibronectin type III domain EphA2_TM PF14575.6 EMC84551.1 - 1.2e-22 80.6 0.0 3e-22 79.3 0.0 1.8 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_1 PF00536.30 EMC84551.1 - 8.1e-14 51.8 0.0 1.5e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC84551.1 - 5.3e-11 42.5 0.0 1.6e-10 40.9 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Pur_ac_phosph_N PF16656.5 EMC84551.1 - 2.1e-07 31.4 0.3 7.7e-06 26.4 0.4 2.6 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Ephrin_rec_like PF07699.13 EMC84551.1 - 4.6e-07 29.5 6.0 4.6e-07 29.5 6.0 2.9 2 1 1 3 3 3 1 Putative ephrin-receptor like fn3_2 PF16893.5 EMC84551.1 - 1.6e-05 24.9 0.5 0.021 15.0 0.0 2.9 3 0 0 3 3 2 2 Fibronectin type III domain DUF4998 PF16389.5 EMC84551.1 - 0.002 17.7 0.0 0.0046 16.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function DUF2369 PF10179.9 EMC84551.1 - 0.0031 17.9 0.6 2.2 8.7 0.0 2.5 1 1 1 2 2 2 2 Uncharacterised conserved protein (DUF2369) TMEM154 PF15102.6 EMC84551.1 - 0.0048 16.8 0.0 0.0087 16.0 0.0 1.3 1 0 0 1 1 1 1 TMEM154 protein family Interfer-bind PF09294.10 EMC84551.1 - 0.0061 16.9 0.0 0.21 11.9 0.0 3.1 3 0 0 3 3 3 1 Interferon-alpha/beta receptor, fibronectin type III Haspin_kinase PF12330.8 EMC84551.1 - 0.012 14.6 0.0 0.021 13.8 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 EMC84551.1 - 0.012 15.0 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Tissue_fac PF01108.17 EMC84551.1 - 0.015 15.2 0.2 8 6.4 0.0 2.6 2 0 0 2 2 2 0 Tissue factor SusE PF14292.6 EMC84551.1 - 0.081 13.2 0.4 0.76 10.0 0.1 2.7 3 1 0 3 3 2 0 SusE outer membrane protein Pkinase_fungal PF17667.1 EMC84551.1 - 0.12 11.2 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Rax2 PF12768.7 EMC84551.1 - 0.12 11.8 0.0 0.26 10.7 0.0 1.5 1 0 0 1 1 1 0 Cortical protein marker for cell polarity Arylsulfotran_N PF17425.2 EMC84551.1 - 1.6 8.8 7.7 0.57 10.2 0.2 3.0 3 1 0 3 3 2 0 Arylsulfotransferase Ig-like domain cEGF PF12662.7 EMC84551.1 - 5.3 7.1 5.9 33 4.5 0.8 2.8 1 1 1 2 2 2 0 Complement Clr-like EGF-like Laminin_G_1 PF00054.23 EMC84552.1 - 2e-32 112.1 0.2 1.4e-25 90.0 0.0 2.2 2 0 0 2 2 2 2 Laminin G domain Laminin_G_2 PF02210.24 EMC84552.1 - 2.9e-23 82.8 0.0 3.2e-14 53.6 0.0 2.2 2 0 0 2 2 2 2 Laminin G domain EGF_CA PF07645.15 EMC84552.1 - 3.2e-19 68.9 59.6 4.7e-08 33.1 9.0 5.0 4 1 0 4 4 4 3 Calcium-binding EGF domain FXa_inhibition PF14670.6 EMC84552.1 - 2.1e-17 63.1 58.1 5.8e-08 32.9 11.0 4.6 4 0 0 4 4 4 3 Coagulation Factor Xa inhibitory site Gla PF00594.20 EMC84552.1 - 6.6e-17 61.4 9.7 6.6e-17 61.4 9.7 2.3 2 0 0 2 2 2 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain EGF PF00008.27 EMC84552.1 - 2.2e-13 50.2 47.5 4.3e-07 30.1 5.9 4.7 4 0 0 4 4 4 4 EGF-like domain cEGF PF12662.7 EMC84552.1 - 4.5e-12 45.7 40.8 5.8e-07 29.3 2.5 5.6 5 0 0 5 5 5 4 Complement Clr-like EGF-like EGF_3 PF12947.7 EMC84552.1 - 1.6e-07 31.4 39.2 0.0018 18.4 6.3 4.8 4 0 0 4 4 4 3 EGF domain hEGF PF12661.7 EMC84552.1 - 1.8e-06 28.4 36.1 0.0014 19.2 2.2 5.2 4 1 1 5 5 5 3 Human growth factor-like EGF Arf PF00025.21 EMC84553.1 - 4.2e-42 143.5 0.2 9.4e-42 142.4 0.0 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.13 EMC84553.1 - 2.3e-07 31.0 0.0 6e-07 29.7 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMC84553.1 - 5.3e-07 29.4 0.0 1.3e-06 28.1 0.0 1.7 1 1 0 1 1 1 1 Ras family SRPRB PF09439.10 EMC84553.1 - 4.9e-06 26.1 0.0 4.9e-06 26.1 0.0 1.8 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EMC84553.1 - 8.7e-05 22.6 0.3 0.00022 21.3 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase G-alpha PF00503.20 EMC84553.1 - 9.4e-05 21.7 0.0 9.4e-05 21.7 0.0 3.2 1 1 1 3 3 3 1 G-protein alpha subunit Syntaxin PF00804.25 EMC84554.1 - 2.2e-58 197.2 19.6 2.2e-58 197.2 19.6 1.9 2 0 0 2 2 2 1 Syntaxin HGD-D PF06050.13 EMC84554.1 - 0.0059 16.4 1.3 0.0059 16.4 1.3 2.0 1 1 1 2 2 2 1 2-hydroxyglutaryl-CoA dehydratase, D-component SKA2 PF16740.5 EMC84554.1 - 0.019 14.7 20.9 0.079 12.7 4.2 4.1 2 2 2 4 4 4 0 Spindle and kinetochore-associated protein 2 SNARE PF05739.19 EMC84554.1 - 0.025 14.5 1.9 0.14 12.1 0.0 2.7 3 0 0 3 3 3 0 SNARE domain DUF4988 PF16378.5 EMC84554.1 - 0.057 13.1 12.3 0.54 9.9 1.6 3.0 3 0 0 3 3 3 0 Domain of unknown function Terminase_6C PF17289.2 EMC84554.1 - 0.19 11.8 3.7 3.9 7.5 0.1 2.6 1 1 1 2 2 2 0 Terminase RNaseH-like domain ALO PF04030.14 EMC84554.1 - 0.2 11.5 4.0 0.13 12.1 1.7 1.8 1 1 1 2 2 2 0 D-arabinono-1,4-lactone oxidase DUF948 PF06103.11 EMC84554.1 - 0.27 11.5 8.6 2.8 8.3 0.4 3.5 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF711 PF05167.12 EMC84554.1 - 1.8 7.4 6.0 1.3 7.8 0.7 2.4 2 1 0 2 2 2 0 Uncharacterised ACR (DUF711) LPP PF04728.13 EMC84554.1 - 6.9 7.1 8.2 7 7.1 0.9 3.6 3 1 0 3 3 3 0 Lipoprotein leucine-zipper Rx_N PF18052.1 EMC84554.1 - 7.3 6.9 12.9 1.9 8.8 1.2 3.3 2 1 1 3 3 3 0 Rx N-terminal domain Methyltr_RsmB-F PF01189.17 EMC84555.1 - 2e-31 109.2 0.0 2.7e-31 108.8 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EMC84555.1 - 0.00026 21.2 0.0 0.00073 19.7 0.0 1.7 1 1 0 1 1 1 1 FtsJ-like methyltransferase Pkinase_Tyr PF07714.17 EMC84556.1 - 1.8e-91 306.0 0.0 1.3e-72 244.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 EMC84556.1 - 3.9e-41 141.2 0.0 8.1e-41 140.1 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 EMC84556.1 - 2.5e-27 95.0 0.0 2.8e-13 50.0 0.0 2.8 3 0 0 3 3 3 2 Fibronectin type III domain EphA2_TM PF14575.6 EMC84556.1 - 3.7e-20 72.6 0.0 7.2e-20 71.7 0.0 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_1 PF00536.30 EMC84556.1 - 1.7e-19 70.0 0.0 3.6e-19 69.0 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC84556.1 - 5.5e-16 58.4 0.0 1.2e-15 57.4 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ephrin_rec_like PF07699.13 EMC84556.1 - 0.00011 21.9 2.3 0.00011 21.9 2.3 2.5 2 1 1 3 3 3 1 Putative ephrin-receptor like Pur_ac_phosph_N PF16656.5 EMC84556.1 - 0.00017 22.1 0.2 0.00042 20.8 0.2 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain SusE PF14292.6 EMC84556.1 - 0.0008 19.6 0.0 1.3 9.3 0.1 2.6 2 1 0 2 2 2 2 SusE outer membrane protein fn3_2 PF16893.5 EMC84556.1 - 0.00099 19.2 0.1 0.051 13.7 0.0 2.4 2 0 0 2 2 2 1 Fibronectin type III domain Haspin_kinase PF12330.8 EMC84556.1 - 0.0085 15.1 0.0 0.013 14.4 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EMC84556.1 - 0.046 13.1 0.0 0.074 12.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Tissue_fac PF01108.17 EMC84556.1 - 0.077 12.9 0.0 0.3 11.0 0.0 1.9 2 0 0 2 2 2 0 Tissue factor UPF0542 PF15086.6 EMC84556.1 - 0.081 12.9 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 Arf PF00025.21 EMC84557.1 - 1.1e-54 184.5 0.0 1.3e-54 184.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EMC84557.1 - 3.6e-13 49.4 3.4 9.9e-08 31.5 0.5 2.5 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 EMC84557.1 - 4e-12 46.4 0.0 5.4e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMC84557.1 - 7.6e-11 41.9 0.0 9e-11 41.6 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EMC84557.1 - 1.4e-10 40.9 0.1 1.8e-10 40.5 0.1 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EMC84557.1 - 1.6e-07 31.0 0.1 1.9e-07 30.7 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMC84557.1 - 2.6e-07 30.7 0.0 3.7e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EMC84557.1 - 0.00025 21.4 0.1 0.0043 17.3 0.1 2.0 1 1 0 1 1 1 1 AAA domain GTP_EFTU PF00009.27 EMC84557.1 - 0.009 15.6 0.0 0.081 12.5 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EMC84557.1 - 0.012 15.1 0.1 0.028 14.0 0.1 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_18 PF13238.6 EMC84557.1 - 0.057 14.0 0.0 0.087 13.4 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EMC84557.1 - 0.12 11.9 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Crystall PF00030.19 EMC84559.1 - 9e-97 317.4 4.0 2.2e-21 75.9 0.0 6.6 6 0 0 6 6 6 6 Beta/Gamma crystallin Ricin_B_lectin PF00652.22 EMC84559.1 - 4.6e-17 62.5 0.1 1.1e-16 61.3 0.1 1.7 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain IL4_i_Ig PF18258.1 EMC84559.1 - 7e-13 48.6 5.6 0.033 14.4 0.0 6.4 6 0 0 6 6 6 5 Interleukin-4 inducing immunoglobulin-binding domain RicinB_lectin_2 PF14200.6 EMC84559.1 - 2.4e-11 44.2 0.9 6.7e-07 29.9 0.0 2.7 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Crystall_3 PF08964.10 EMC84559.1 - 0.51 10.5 2.4 21 5.4 0.0 4.2 5 0 0 5 5 5 0 Beta/Gamma crystallin Cupin_4 PF08007.12 EMC84560.1 - 1.1e-90 304.4 0.0 1.4e-90 304.0 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 EMC84560.1 - 4e-06 26.7 0.1 0.012 15.4 0.1 2.3 1 1 1 2 2 2 2 Cupin-like domain Cupin_2 PF07883.11 EMC84560.1 - 0.00036 20.2 0.1 0.01 15.5 0.1 2.3 1 1 0 1 1 1 1 Cupin domain T2SSF PF00482.23 EMC84560.1 - 0.044 13.7 0.0 0.071 13.1 0.0 1.3 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F AraC_binding PF02311.19 EMC84560.1 - 0.12 12.3 0.6 0.53 10.2 0.1 2.4 2 1 0 2 2 2 0 AraC-like ligand binding domain Neur_chan_LBD PF02931.23 EMC84561.1 - 2.5e-51 174.2 0.0 3.9e-51 173.6 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC84561.1 - 2e-34 119.7 9.1 2.2e-30 106.5 4.1 2.2 1 1 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Tmpp129 PF10272.9 EMC84561.1 - 0.27 10.5 1.9 0.6 9.4 1.9 1.5 1 0 0 1 1 1 0 Putative transmembrane protein precursor CcmD PF04995.14 EMC84561.1 - 1 9.5 3.2 9.3 6.4 0.8 2.4 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) WD40 PF00400.32 EMC84562.1 - 7.9e-18 64.5 8.9 0.01 16.7 0.1 7.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC84562.1 - 4.8e-09 36.4 0.0 0.032 14.5 0.0 4.6 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EMC84562.1 - 0.11 11.8 0.1 0.2 10.9 0.1 1.5 1 0 0 1 1 1 0 WD40-like domain MPC PF03650.13 EMC84563.1 - 1.5e-36 124.8 0.8 1.7e-36 124.7 0.8 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers V-set PF07686.17 EMC84564.1 - 1.1e-21 77.0 0.0 1.6e-21 76.5 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 EMC84564.1 - 1.2e-07 31.8 0.0 5.5e-07 29.7 0.0 2.0 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC84564.1 - 1.3e-05 25.7 0.6 7e-05 23.4 0.1 2.4 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 EMC84564.1 - 7.4e-05 22.8 0.1 0.00031 20.8 0.1 1.9 1 1 0 1 1 1 1 Immunoglobulin I-set domain Myelin-PO_C PF10570.9 EMC84564.1 - 0.035 14.5 0.0 0.084 13.3 0.0 1.6 1 0 0 1 1 1 0 Myelin-PO cytoplasmic C-term p65 binding region Ig_2 PF13895.6 EMC84564.1 - 0.066 13.6 0.1 0.71 10.2 0.1 2.2 1 1 0 1 1 1 0 Immunoglobulin domain CAP-ZIP_m PF15255.6 EMC84565.1 - 9.7e-22 77.7 1.8 3.2e-21 76.0 1.8 1.9 1 0 0 1 1 1 1 WASH complex subunit CAP-Z interacting, central region Pyrid_oxidase_2 PF13883.6 EMC84566.1 - 2.6e-57 193.5 0.0 3e-57 193.3 0.0 1.0 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 EMC84566.1 - 0.16 12.2 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase ITAM PF02189.15 EMC84567.1 - 1e-11 44.6 0.4 2e-06 27.9 0.1 2.5 2 0 0 2 2 2 2 Immunoreceptor tyrosine-based activation motif Pou PF00157.17 EMC84568.1 - 3.1e-38 129.6 0.2 7.2e-38 128.4 0.2 1.7 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 EMC84568.1 - 1.5e-17 63.2 2.7 3.8e-17 61.9 2.7 1.7 1 0 0 1 1 1 1 Homeodomain HTH_31 PF13560.6 EMC84568.1 - 0.06 13.7 0.1 1.4 9.3 0.0 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain Homeobox_KN PF05920.11 EMC84568.1 - 0.067 13.1 0.1 0.18 11.7 0.1 1.8 1 0 0 1 1 1 0 Homeobox KN domain Popeye PF04831.13 EMC84569.1 - 8.1e-50 168.6 0.1 9.9e-50 168.4 0.1 1.1 1 0 0 1 1 1 1 Popeye protein conserved region cNMP_binding PF00027.29 EMC84569.1 - 0.0032 17.5 0.0 0.0061 16.6 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain CAP_N PF01213.19 EMC84569.1 - 0.31 10.5 4.5 0.43 10.0 4.5 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal CFAP91 PF14738.6 EMC84570.1 - 2.4e-65 219.3 8.6 4.7e-65 218.3 8.6 1.5 1 0 0 1 1 1 1 Cilia- and flagella-associated protein 91 DUF572 PF04502.13 EMC84570.1 - 0.0022 17.7 3.7 0.0032 17.1 3.7 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF572) DUF5624 PF18538.1 EMC84570.1 - 0.016 15.3 0.4 0.077 13.1 0.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5624) Pkinase PF00069.25 EMC84571.1 - 1.3e-68 231.2 0.0 1.6e-68 231.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC84571.1 - 2.4e-24 86.0 0.0 3e-24 85.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC84571.1 - 5.1e-05 22.7 0.0 0.00039 19.8 0.0 1.9 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 EMC84571.1 - 0.0055 16.7 0.1 0.012 15.5 0.1 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EMC84571.1 - 0.024 14.0 0.0 0.036 13.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.16 EMC84571.1 - 0.077 13.2 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 ABC1 family 7tm_3 PF00003.22 EMC84572.1 - 1.4e-38 133.0 20.7 1.9e-38 132.6 20.7 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NYD-SP28 PF14772.6 EMC84572.1 - 0.18 11.9 1.8 0.32 11.1 1.8 1.3 1 0 0 1 1 1 0 Sperm tail Kazal_2 PF07648.15 EMC84573.1 - 1.9e-13 50.3 5.9 1.9e-13 50.3 5.9 2.5 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EMC84573.1 - 2e-06 27.7 10.1 7.1e-06 25.9 10.1 2.0 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain FOLN PF09289.10 EMC84573.1 - 2.5e-06 27.5 2.1 2.5e-06 27.5 2.1 2.5 2 0 0 2 2 2 1 Follistatin/Osteonectin-like EGF domain Pacifastin_I PF05375.13 EMC84573.1 - 0.00066 19.4 9.3 0.00066 19.4 9.3 2.8 3 1 0 3 3 3 1 Pacifastin inhibitor (LCMII) EF-hand_7 PF13499.6 EMC84573.1 - 0.0019 18.6 2.9 0.0068 16.8 0.4 2.7 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 EMC84573.1 - 0.021 14.7 0.0 2.4 8.3 0.0 2.9 3 0 0 3 3 3 0 EF-hand domain Hormone_3 PF00159.18 EMC84573.1 - 0.038 14.1 0.2 0.082 13.0 0.2 1.6 1 0 0 1 1 1 0 Pancreatic hormone peptide EF-hand_1 PF00036.32 EMC84573.1 - 0.13 11.9 1.2 13 5.6 0.0 3.0 3 0 0 3 3 3 0 EF hand NDUF_B4 PF07225.12 EMC84574.1 - 6.9e-29 100.3 0.0 7.3e-29 100.2 0.0 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) PEN-2 PF10251.9 EMC84574.1 - 0.06 13.8 0.0 0.065 13.7 0.0 1.1 1 0 0 1 1 1 0 Presenilin enhancer-2 subunit of gamma secretase HgmA PF04209.13 EMC84575.1 - 9.5e-222 736.2 0.0 1.1e-221 736.0 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase Roc PF08477.13 EMC84576.1 - 6.8e-11 42.4 0.0 3.6e-10 40.1 0.0 1.9 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMC84576.1 - 1.5e-08 34.4 0.0 5.5e-08 32.6 0.0 1.8 1 1 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 EMC84576.1 - 0.004 17.2 0.0 0.0054 16.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 EMC84576.1 - 0.16 11.4 0.1 0.52 9.7 0.1 1.9 1 1 0 1 1 1 0 ADP-ribosylation factor family TFIIE_alpha PF02002.17 EMC84577.1 - 8.6e-36 122.0 0.6 1.5e-35 121.2 0.6 1.4 1 0 0 1 1 1 1 TFIIE alpha subunit TFIIE-A_C PF11521.8 EMC84577.1 - 2e-30 104.9 5.0 6.7e-30 103.2 5.0 2.0 1 0 0 1 1 1 1 C-terminal general transcription factor TFIIE alpha TF_Zn_Ribbon PF08271.12 EMC84577.1 - 9.5e-12 44.2 1.0 1.8e-11 43.3 1.0 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding OrfB_Zn_ribbon PF07282.11 EMC84577.1 - 0.052 13.5 0.1 0.093 12.7 0.1 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-Sec23_Sec24 PF04810.15 EMC84577.1 - 0.13 12.3 0.4 11 6.2 0.1 2.4 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger PyrI_C PF02748.15 EMC84577.1 - 0.37 10.7 1.6 1.3 9.0 1.8 1.9 1 1 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_4 PF13894.6 EMC84577.1 - 1 10.4 3.0 6 8.0 0.3 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger DEAD PF00270.29 EMC84578.1 - 1.4e-18 67.2 0.0 1.1e-17 64.3 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC84578.1 - 4.8e-12 46.2 0.0 2.2e-10 40.8 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC84578.1 - 4.6e-06 26.7 0.0 1.2e-05 25.4 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF4332 PF14229.6 EMC84578.1 - 6.8e-05 23.1 0.0 0.00023 21.4 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4332) HHH_5 PF14520.6 EMC84578.1 - 0.00051 20.6 0.2 0.0042 17.7 0.0 2.5 3 0 0 3 3 3 1 Helix-hairpin-helix domain Methyltransf_10 PF05971.12 EMC84579.1 - 2.5e-80 270.0 0.0 3.6e-80 269.5 0.0 1.3 1 0 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 EMC84579.1 - 0.0022 17.6 0.0 0.004 16.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain MANEC PF07502.14 EMC84579.1 - 0.0039 17.4 0.8 0.01 16.1 0.3 1.9 2 0 0 2 2 2 1 MANEC domain PrmA PF06325.13 EMC84579.1 - 0.063 12.7 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Death PF00531.22 EMC84580.1 - 4.5e-18 65.2 0.1 7.6e-18 64.5 0.1 1.4 1 0 0 1 1 1 1 Death domain TNFR_c6 PF00020.18 EMC84580.1 - 8.6e-18 64.5 49.9 3.2e-08 33.8 11.3 4.9 4 1 0 4 4 4 4 TNFR/NGFR cysteine-rich region DUF5534 PF17686.1 EMC84580.1 - 0.06 13.6 0.0 0.094 13.0 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5534) CTC1 PF15489.6 EMC84581.1 - 4.6e-70 236.4 2.0 6.9e-40 136.5 0.8 2.0 1 1 0 2 2 2 2 CST, telomere maintenance, complex subunit CTC1 CTC1 PF15489.6 EMC84582.1 - 1.3e-50 172.0 0.8 1.5e-50 171.9 0.8 1.0 1 0 0 1 1 1 1 CST, telomere maintenance, complex subunit CTC1 V-set PF07686.17 EMC84583.1 - 4.9e-11 42.8 0.1 9.3e-09 35.4 0.0 3.0 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC84583.1 - 8.5e-10 39.1 0.1 0.00016 22.2 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC84583.1 - 9.2e-08 32.1 0.4 0.00035 20.6 0.0 2.7 2 2 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 EMC84583.1 - 4.6e-06 26.7 0.9 0.0002 21.5 0.0 3.0 2 2 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 EMC84583.1 - 2.3e-05 24.6 1.3 0.12 12.8 0.0 2.6 1 1 0 2 2 2 2 Immunoglobulin domain Izumo-Ig PF16706.5 EMC84583.1 - 0.0006 19.8 0.0 0.0019 18.3 0.0 1.8 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain C1-set PF07654.15 EMC84583.1 - 0.0086 16.4 0.4 0.3 11.5 0.1 2.7 2 1 0 2 2 2 1 Immunoglobulin C1-set domain Ig_6 PF18452.1 EMC84583.1 - 0.016 14.8 0.0 0.58 9.8 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin domain Filamin PF00630.19 EMC84584.1 - 9.6e-22 77.8 0.0 1.6e-21 77.1 0.0 1.3 1 0 0 1 1 1 1 Filamin/ABP280 repeat zf-B_box PF00643.24 EMC84584.1 - 6.5e-10 39.0 7.4 6.5e-10 39.0 7.4 2.8 3 0 0 3 3 3 1 B-box zinc finger DUF5060 PF16586.5 EMC84584.1 - 0.052 13.9 0.0 0.12 12.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5060) Y_Y_Y PF07495.13 EMC84584.1 - 0.18 11.8 0.0 0.32 11.0 0.0 1.3 1 0 0 1 1 1 0 Y_Y_Y domain Laminin_II PF06009.12 EMC84584.1 - 0.18 11.8 0.4 0.33 11.0 0.4 1.4 1 0 0 1 1 1 0 Laminin Domain II F-box-like PF12937.7 EMC84585.1 - 2.5e-12 46.5 1.0 2.7e-12 46.4 1.0 1.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMC84585.1 - 7.2e-07 28.9 0.1 7.4e-07 28.9 0.1 1.0 1 0 0 1 1 1 1 F-box domain Latrophilin PF02354.16 EMC84586.1 - 7.5e-174 578.2 13.4 1e-173 577.7 13.4 1.2 1 0 0 1 1 1 1 Latrophilin Cytoplasmic C-terminal region OLF PF02191.16 EMC84586.1 - 2.5e-85 286.0 5.3 4.8e-85 285.1 5.3 1.5 1 0 0 1 1 1 1 Olfactomedin-like domain 7tm_2 PF00002.24 EMC84586.1 - 1.9e-68 230.4 17.9 2.8e-68 229.9 17.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.5 EMC84586.1 - 2.3e-54 184.0 0.6 3.5e-54 183.4 0.6 1.3 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Gal_Lectin PF02140.18 EMC84586.1 - 1e-23 83.5 0.7 3e-23 82.1 0.7 1.9 1 0 0 1 1 1 1 Galactose binding lectin domain GPS PF01825.21 EMC84586.1 - 2.9e-15 56.5 5.8 8.1e-15 55.1 5.8 1.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif HRM PF02793.22 EMC84586.1 - 3.8e-09 36.7 1.5 1e-08 35.4 1.5 1.8 1 0 0 1 1 1 1 Hormone receptor domain zf-C2HCIx2C PF10782.9 EMC84586.1 - 0.91 9.5 4.8 2.1 8.3 4.8 1.6 1 0 0 1 1 1 0 Zinc-finger DUF5074 PF16819.5 EMC84586.1 - 1.3 9.1 5.1 2.8 8.0 0.8 3.4 1 1 2 3 3 3 0 Domain of unknown function (DUF5074) 7tm_2 PF00002.24 EMC84587.1 - 3e-58 197.0 27.9 5.6e-58 196.1 27.9 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.5 EMC84587.1 - 1.6e-44 151.8 6.5 2.2e-44 151.4 6.5 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain GPS PF01825.21 EMC84587.1 - 1e-15 58.0 6.7 2.6e-15 56.6 6.7 1.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif EGF_CA PF07645.15 EMC84587.1 - 3.3e-05 24.0 7.0 3.3e-05 24.0 7.0 1.9 1 1 0 1 1 1 1 Calcium-binding EGF domain EGF_3 PF12947.7 EMC84587.1 - 5e-05 23.4 4.4 5e-05 23.4 4.4 3.1 3 0 0 3 3 3 1 EGF domain cEGF PF12662.7 EMC84587.1 - 0.00036 20.4 3.0 0.00093 19.1 3.0 1.8 1 0 0 1 1 1 1 Complement Clr-like EGF-like Plasmod_Pvs28 PF06247.11 EMC84587.1 - 0.0024 18.1 20.5 0.012 15.9 5.7 3.2 3 0 0 3 3 2 2 Pvs28 EGF domain EGF PF00008.27 EMC84587.1 - 0.014 15.6 5.0 0.014 15.6 5.0 2.6 3 0 0 3 3 3 0 EGF-like domain hEGF PF12661.7 EMC84587.1 - 0.21 12.3 11.3 0.043 14.5 6.7 2.4 2 0 0 2 2 2 0 Human growth factor-like EGF MKT1_N PF12247.8 EMC84587.1 - 0.31 11.4 2.4 3.5 8.0 0.1 3.1 2 1 1 3 3 3 0 Temperature dependent protein affecting M2 dsRNA replication DUF2371 PF10177.9 EMC84587.1 - 0.43 10.8 0.1 0.43 10.8 0.1 2.8 3 0 0 3 3 2 0 Uncharacterised conserved protein (DUF2371) Pox_A14 PF05767.12 EMC84587.1 - 1.1 9.5 9.4 0.62 10.3 3.4 2.9 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 FXa_inhibition PF14670.6 EMC84587.1 - 1.2 9.4 12.4 0.03 14.6 5.2 2.2 2 0 0 2 2 2 0 Coagulation Factor Xa inhibitory site Vitellogenin_N PF01347.22 EMC84588.1 - 4e-151 504.5 1.9 4e-151 504.5 1.9 3.4 2 1 0 2 2 2 1 Lipoprotein amino terminal region DUF1943 PF09172.11 EMC84588.1 - 1.5e-60 205.1 1.0 1.5e-60 205.1 1.0 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF1943) DUF1944 PF09175.10 EMC84588.1 - 2.2e-57 193.5 0.5 2.2e-57 193.5 0.5 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1944) VWD PF00094.25 EMC84588.1 - 1.5e-24 87.1 0.7 1.5e-24 87.1 0.7 3.1 3 1 0 3 3 3 1 von Willebrand factor type D domain HEAT_2 PF13646.6 EMC84588.1 - 0.0062 16.9 0.0 0.062 13.7 0.0 2.7 1 1 1 2 2 2 2 HEAT repeats 7tm_1 PF00001.21 EMC84589.1 - 3.5e-21 75.7 16.1 3.5e-21 75.7 16.1 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC84589.1 - 0.00011 21.9 18.9 0.00015 21.5 18.3 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Serpentine_r_xa PF03383.15 EMC84589.1 - 0.00023 21.2 3.4 0.00023 21.2 3.4 2.8 1 1 1 3 3 3 1 Caenorhabditis serpentine receptor-like protein, class xa NPCC PF08058.11 EMC84589.1 - 3.5 7.7 8.8 48 4.0 4.9 3.1 2 1 0 2 2 2 0 Nuclear pore complex component CopD PF05425.13 EMC84589.1 - 8.1 6.9 8.8 2.9 8.3 0.8 3.2 2 2 0 3 3 3 0 Copper resistance protein D PDZ PF00595.24 EMC84590.1 - 1.2e-08 35.2 0.1 2.2e-08 34.4 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC84590.1 - 0.0016 18.2 0.0 0.0032 17.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC84590.1 - 0.014 15.7 0.0 0.035 14.4 0.0 1.7 2 0 0 2 2 2 0 PDZ domain DnaJ_C PF01556.18 EMC84591.1 - 1.9e-44 151.3 0.2 2.5e-44 150.9 0.2 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EMC84591.1 - 5.8e-29 100.0 3.4 1.1e-28 99.2 3.4 1.5 1 0 0 1 1 1 1 DnaJ domain RPT PF13446.6 EMC84591.1 - 0.19 11.7 0.0 0.5 10.3 0.0 1.7 1 0 0 1 1 1 0 A repeated domain in UCH-protein KH_1 PF00013.29 EMC84592.1 - 5.3e-64 212.0 18.7 2.2e-18 65.8 0.1 4.7 4 1 0 4 4 4 4 KH domain KH_2 PF07650.17 EMC84592.1 - 4.2e-18 64.9 11.4 3.5e-05 23.6 0.3 4.4 4 0 0 4 4 4 4 KH domain DUF1897 PF09005.10 EMC84592.1 - 7.2e-13 47.8 20.7 1.1e-06 28.0 6.9 3.8 3 0 0 3 3 3 3 Domain of unknown function (DUF1897) KH_4 PF13083.6 EMC84592.1 - 1.6e-05 24.7 10.3 0.17 11.7 0.1 4.2 4 0 0 4 4 4 3 KH domain Secretin_N PF03958.17 EMC84592.1 - 0.00062 20.1 0.5 0.086 13.2 0.5 3.3 3 1 1 4 4 4 1 Bacterial type II/III secretion system short domain KH_5 PF13184.6 EMC84592.1 - 1.9 8.6 10.8 4.7 7.4 0.1 3.6 4 0 0 4 4 4 0 NusA-like KH domain I-set PF07679.16 EMC84593.1 - 2.1e-18 66.2 0.3 7.7e-18 64.4 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC84593.1 - 2.2e-10 41.0 0.0 6e-10 39.6 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC84593.1 - 7.9e-07 29.2 0.1 3.5e-06 27.1 0.1 2.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC84593.1 - 0.0047 17.2 0.0 0.009 16.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain COMM_domain PF07258.14 EMC84593.1 - 0.45 10.7 4.5 1.5 9.0 4.5 1.9 1 0 0 1 1 1 0 COMM domain Miga PF10265.9 EMC84594.1 - 1.6e-254 845.9 3.3 1.8e-254 845.7 3.3 1.0 1 0 0 1 1 1 1 Mitoguardin UCH PF00443.29 EMC84595.1 - 3.9e-63 213.3 0.0 3.6e-62 210.2 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 EMC84595.1 - 5.1e-25 87.9 0.2 5.9e-14 52.5 0.0 3.2 3 0 0 3 3 3 2 DUSP domain UCH_1 PF13423.6 EMC84595.1 - 1e-19 71.3 6.7 5.6e-19 68.9 0.1 4.2 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EMC84595.1 - 3.7e-16 59.2 10.3 3.7e-16 59.2 10.3 3.2 4 0 0 4 4 4 1 Zn-finger in ubiquitin-hydrolases and other protein zinc_ribbon_9 PF14369.6 EMC84595.1 - 0.6 10.4 3.8 1.7 9.0 0.3 3.2 2 0 0 2 2 2 0 zinc-ribbon Myb_DNA-binding PF00249.31 EMC84596.1 - 4.3e-10 39.6 0.5 1.1e-09 38.3 0.5 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EMC84596.1 - 8.4e-06 26.0 0.1 2.6e-05 24.4 0.1 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 EMC84596.1 - 1.2e-05 25.0 7.8 1.2e-05 25.0 7.8 2.2 2 0 0 2 2 2 1 Zinc finger, ZZ type ADK PF00406.22 EMC84597.1 - 5.8e-77 257.0 0.0 2.7e-40 137.9 0.0 2.2 2 0 0 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 EMC84597.1 - 2.5e-55 186.6 0.1 1.4e-27 96.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EMC84597.1 - 6.8e-23 81.6 0.1 2e-09 38.1 0.0 3.3 2 1 1 3 3 3 3 AAA domain AAA_33 PF13671.6 EMC84597.1 - 1.2e-11 45.0 0.1 0.00018 21.7 0.2 3.3 2 2 0 2 2 2 2 AAA domain Hydin_ADK PF17213.3 EMC84597.1 - 4.8e-07 30.3 0.0 0.038 14.3 0.0 2.6 2 0 0 2 2 2 2 Hydin Adenylate kinase-like domain Thymidylate_kin PF02223.17 EMC84597.1 - 9.1e-07 28.7 5.4 0.013 15.2 0.1 4.0 4 0 0 4 4 4 2 Thymidylate kinase Cytidylate_kin PF02224.18 EMC84597.1 - 1.9e-06 27.7 0.7 0.3 10.8 0.1 3.3 2 1 1 3 3 3 2 Cytidylate kinase Zeta_toxin PF06414.12 EMC84597.1 - 2.5e-06 26.9 0.2 0.01 15.2 0.0 2.8 3 0 0 3 3 3 2 Zeta toxin dNK PF01712.19 EMC84597.1 - 6.7e-05 22.8 0.4 0.08 12.8 0.0 3.4 3 0 0 3 3 3 1 Deoxynucleoside kinase AAA PF00004.29 EMC84597.1 - 0.00024 21.5 0.2 0.31 11.5 0.0 2.6 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EMC84597.1 - 0.00026 21.3 0.0 0.34 11.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EMC84597.1 - 0.00046 20.6 0.6 0.81 10.1 0.1 3.0 2 2 0 2 2 2 2 AAA ATPase domain AAA_19 PF13245.6 EMC84597.1 - 0.00056 20.3 0.1 0.93 9.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain Ploopntkinase3 PF18751.1 EMC84597.1 - 0.0012 18.8 0.0 0.44 10.4 0.0 2.3 2 0 0 2 2 2 1 P-loop Nucleotide Kinase3 AAA_22 PF13401.6 EMC84597.1 - 0.016 15.5 2.8 3.4 8.0 0.1 3.2 2 2 1 3 3 3 0 AAA domain SRP54 PF00448.22 EMC84597.1 - 0.026 14.1 0.5 8.8 5.9 0.0 2.9 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain ATPase PF06745.13 EMC84597.1 - 0.062 12.6 0.3 7.4 5.8 0.0 2.7 3 0 0 3 3 3 0 KaiC CobU PF02283.16 EMC84597.1 - 0.064 12.8 1.6 10 5.6 0.0 3.6 4 0 0 4 4 4 0 Cobinamide kinase / cobinamide phosphate guanyltransferase DUF2075 PF09848.9 EMC84597.1 - 0.079 12.2 0.1 6.9 5.8 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) SKI PF01202.22 EMC84597.1 - 0.096 12.8 0.5 45 4.1 0.0 3.7 4 0 0 4 4 4 0 Shikimate kinase Peptidase_C13 PF01650.18 EMC84598.1 - 3.7e-39 134.8 0.0 4.9e-39 134.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase C13 family ArgoMid PF16487.5 EMC84598.1 - 0.0095 16.2 0.1 0.03 14.6 0.1 1.8 1 0 0 1 1 1 1 Mid domain of argonaute Peptidase_C14 PF00656.22 EMC84598.1 - 0.054 13.4 0.0 0.07 13.1 0.0 1.2 1 0 0 1 1 1 0 Caspase domain Glyco_transf_29 PF00777.18 EMC84599.1 - 1.2e-36 126.6 0.1 1.4e-36 126.3 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Glyco_transf_29 PF00777.18 EMC84600.1 - 6.2e-36 124.2 0.7 8e-36 123.8 0.7 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) PIF PF05092.12 EMC84600.1 - 0.0042 15.9 0.1 0.0056 15.5 0.1 1.1 1 0 0 1 1 1 1 Per os infectivity PIF1 PF05970.14 EMC84601.1 - 1.2e-22 80.6 0.0 2.5e-22 79.5 0.0 1.4 1 1 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 EMC84601.1 - 0.0008 19.2 0.0 0.02 14.6 0.0 2.4 1 1 0 1 1 1 1 AAA domain BTB PF00651.31 EMC84602.1 - 6.4e-27 94.0 0.3 1.1e-26 93.3 0.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 EMC84602.1 - 3.7e-16 58.7 17.6 4.2e-07 30.1 4.1 4.4 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 EMC84602.1 - 3.4e-12 46.1 20.7 2.1e-05 24.7 1.9 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC84602.1 - 2.7e-09 37.1 18.3 0.0042 17.8 1.1 4.0 3 0 0 3 3 3 3 C2H2-type zinc finger DUF3342 PF11822.8 EMC84602.1 - 1.8e-05 24.8 0.1 3.5e-05 23.9 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) zf-C2H2_2 PF12756.7 EMC84602.1 - 0.00074 19.8 7.0 0.076 13.4 0.0 3.4 1 1 2 3 3 3 1 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 EMC84602.1 - 0.0017 18.6 16.6 0.035 14.5 0.7 4.4 5 0 0 5 5 3 2 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 EMC84602.1 - 0.0028 17.4 3.7 1.2 8.9 0.2 2.9 3 0 0 3 3 3 2 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 EMC84602.1 - 0.011 16.0 9.9 0.11 12.9 0.1 3.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 EMC84602.1 - 0.084 13.3 9.0 2.7 8.5 1.7 3.5 1 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger BTB_2 PF02214.22 EMC84602.1 - 0.11 12.8 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 BTB/POZ domain PyrI_C PF02748.15 EMC84602.1 - 0.26 11.2 3.4 10 6.1 0.1 3.2 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zinc_ribbon_15 PF17032.5 EMC84602.1 - 0.29 11.9 2.7 1.1 10.0 0.6 2.3 1 1 1 2 2 2 0 zinc-ribbon family zf-Di19 PF05605.12 EMC84602.1 - 0.57 10.5 9.0 0.14 12.5 0.9 2.5 1 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Elf1 PF05129.13 EMC84602.1 - 0.96 9.5 3.3 0.85 9.7 0.6 2.1 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf-AN1 PF01428.16 EMC84602.1 - 1.3 9.2 7.0 19 5.5 0.1 3.2 3 0 0 3 3 3 0 AN1-like Zinc finger HNH_5 PF14279.6 EMC84602.1 - 1.8 8.4 5.2 27 4.7 0.1 3.3 3 0 0 3 3 3 0 HNH endonuclease zf_C2H2_ZHX PF18387.1 EMC84602.1 - 1.9 8.2 9.1 15 5.3 0.2 3.3 1 1 2 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-trcl PF13451.6 EMC84602.1 - 2.2 8.2 5.6 2.4 8.1 0.2 2.6 2 1 1 3 3 3 0 Probable zinc-ribbon domain zf-C2H2_11 PF16622.5 EMC84602.1 - 2.9 7.7 15.7 2.4 8.0 1.0 3.7 4 0 0 4 4 3 0 zinc-finger C2H2-type zf-BED PF02892.15 EMC84602.1 - 3.3 7.8 16.2 4.7 7.3 0.6 3.5 1 1 1 2 2 2 0 BED zinc finger PriA_CRR PF18319.1 EMC84602.1 - 4.2 7.4 7.8 27 4.9 0.9 3.3 3 0 0 3 3 3 0 PriA DNA helicase Cys-rich region (CRR) domain zf-C2H2_6 PF13912.6 EMC84602.1 - 4.5 7.4 13.7 0.75 9.9 1.6 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 EMC84602.1 - 6.3 7.5 8.0 19 5.9 0.7 3.3 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_12 PF18658.1 EMC84602.1 - 8 6.1 8.1 0.79 9.3 0.4 2.9 1 1 2 3 3 3 0 Zinc-finger C2H2-type FYVE PF01363.21 EMC84602.1 - 9.9 6.4 11.1 4.6e+02 1.0 11.1 2.6 1 1 0 1 1 1 0 FYVE zinc finger Serpin PF00079.20 EMC84603.1 - 6.1e-114 381.2 0.1 6.9e-114 381.0 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) CagE_TrbE_VirB PF03135.14 EMC84603.1 - 0.019 15.1 1.2 3.3 7.8 0.4 2.2 1 1 1 2 2 2 0 CagE, TrbE, VirB family, component of type IV transporter system ROQ_II PF18386.1 EMC84604.1 - 2.1e-33 113.9 0.6 4e-33 113.0 0.6 1.5 1 0 0 1 1 1 1 Roquin II domain zf-RING_UBOX PF13445.6 EMC84604.1 - 4.1e-06 26.7 6.7 9.4e-06 25.6 6.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EMC84604.1 - 5.2e-06 26.2 6.4 0.00011 22.0 1.7 2.6 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EMC84604.1 - 1.6e-05 24.6 3.8 3.2e-05 23.7 3.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC84604.1 - 2.7e-05 24.4 6.4 5.3e-05 23.5 6.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 EMC84604.1 - 3.4e-05 23.9 5.1 7.4e-05 22.8 5.1 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EMC84604.1 - 3.8e-05 23.6 6.4 8e-05 22.5 6.4 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EMC84604.1 - 0.00017 21.4 7.2 0.00034 20.4 7.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH PF00642.24 EMC84604.1 - 0.00026 20.8 3.0 0.00026 20.8 3.0 2.2 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_2 PF13923.6 EMC84604.1 - 0.0016 18.3 7.4 0.0037 17.1 7.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 EMC84604.1 - 0.0018 18.4 1.2 0.0037 17.4 1.2 1.5 1 0 0 1 1 1 1 FYVE zinc finger zf_CCCH_4 PF18345.1 EMC84604.1 - 0.0076 16.3 2.4 0.023 14.8 2.4 1.9 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 EMC84604.1 - 0.033 14.0 2.0 0.069 13.0 2.0 1.6 1 0 0 1 1 1 0 CCCH-type zinc finger PaaA_PaaC PF05138.12 EMC84604.1 - 0.038 13.1 0.1 0.065 12.4 0.1 1.3 1 0 0 1 1 1 0 Phenylacetic acid catabolic protein DUF743 PF05332.11 EMC84604.1 - 0.043 13.9 0.0 0.18 11.9 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF743) Baculo_IE-1 PF05290.11 EMC84604.1 - 0.058 13.4 1.5 0.13 12.2 1.5 1.5 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_4 PF14570.6 EMC84604.1 - 0.062 13.1 4.9 0.14 12.0 4.9 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 EMC84604.1 - 0.21 11.7 8.0 0.088 13.0 4.1 2.3 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-RING_6 PF14835.6 EMC84604.1 - 0.22 11.4 1.3 0.47 10.3 1.3 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_5 PF17121.5 EMC84604.1 - 0.59 10.1 2.8 1.6 8.7 2.8 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) 7tm_4 PF13853.6 EMC84605.1 - 6.6e-41 140.9 10.2 8.5e-41 140.5 10.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC84605.1 - 1.2e-23 83.8 13.9 1.9e-23 83.1 13.9 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Yae1_N PF09811.9 EMC84607.1 - 2.3e-09 36.8 30.2 91 2.9 30.2 3.3 1 1 0 1 1 1 1 Essential protein Yae1, N terminal MACPF PF01823.19 EMC84608.1 - 8e-07 29.4 0.2 4.2e-06 27.0 0.0 2.1 2 0 0 2 2 2 1 MAC/Perforin domain DUF2717 PF10911.8 EMC84610.1 - 1.8 8.3 2.9 83 3.0 0.0 3.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2717) Colicin_V PF02674.16 EMC84610.1 - 2.5 8.1 6.4 13 5.8 0.6 2.2 2 0 0 2 2 2 0 Colicin V production protein Glyco_hydro_31 PF01055.26 EMC84611.1 - 4e-07 29.6 0.0 4.4e-07 29.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 DUF148 PF02520.17 EMC84613.1 - 0.0029 17.7 4.8 0.011 15.9 4.8 2.0 1 0 0 1 1 1 1 Domain of unknown function DUF148 TPR_MLP1_2 PF07926.12 EMC84613.1 - 0.005 16.9 21.5 0.005 16.9 21.5 3.2 3 1 1 4 4 4 1 TPR/MLP1/MLP2-like protein DivIC PF04977.15 EMC84613.1 - 0.014 15.2 24.5 1.2 9.0 0.1 4.6 2 1 2 4 4 4 0 Septum formation initiator TMF_TATA_bd PF12325.8 EMC84613.1 - 0.13 12.5 32.8 0.15 12.2 3.1 4.2 2 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding ERM PF00769.19 EMC84613.1 - 0.94 9.2 40.2 0.0084 16.0 20.0 2.4 1 1 1 2 2 2 0 Ezrin/radixin/moesin family PKcGMP_CC PF16808.5 EMC84613.1 - 1.1 9.2 10.1 1.5 8.7 1.0 3.8 2 1 1 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase EzrA PF06160.12 EMC84613.1 - 3 5.9 20.2 5 5.2 12.5 2.1 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Spc7 PF08317.11 EMC84613.1 - 3.9 6.3 32.2 7.2 5.4 16.6 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein Fez1 PF06818.15 EMC84613.1 - 6.3 7.2 29.8 1.4 9.3 23.2 2.7 1 1 1 2 2 2 0 Fez1 CENP-F_leu_zip PF10473.9 EMC84613.1 - 7.2 6.6 38.5 1.4 9.0 12.1 3.5 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMEM51 PF15345.6 EMC84614.1 - 1.3e-85 287.0 0.0 1.7e-85 286.6 0.0 1.1 1 0 0 1 1 1 1 Transmembrane protein 51 TMEM61 PF15105.6 EMC84614.1 - 7.3e-06 25.9 0.5 0.00028 20.8 0.0 2.7 2 1 1 3 3 3 1 TMEM61 protein family WBP-1 PF11669.8 EMC84614.1 - 0.0017 19.0 0.1 0.19 12.4 0.0 2.7 3 0 0 3 3 3 1 WW domain-binding protein 1 RCR PF12273.8 EMC84614.1 - 0.0024 18.5 0.7 0.023 15.3 0.1 2.2 1 1 1 2 2 2 1 Chitin synthesis regulation, resistance to Congo red Shisa PF13908.6 EMC84614.1 - 0.038 14.2 0.0 0.095 12.9 0.0 1.8 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator FAM176 PF14851.6 EMC84614.1 - 0.045 13.4 0.0 0.068 12.8 0.0 1.3 1 0 0 1 1 1 0 FAM176 family DUF465 PF04325.13 EMC84614.1 - 0.049 13.7 1.1 0.11 12.6 1.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF465) Trp_oprn_chp PF09534.10 EMC84614.1 - 0.14 11.9 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) CRPA PF05745.11 EMC84614.1 - 0.4 10.7 0.9 17 5.4 0.0 2.2 2 0 0 2 2 2 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) DUF3040 PF11239.8 EMC84614.1 - 0.66 10.3 2.1 2.8 8.3 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) TMEM100 PF16311.5 EMC84614.1 - 6.5 6.3 4.9 1.2 8.8 0.4 2.1 2 1 1 3 3 3 0 Transmembrane protein 100 DUF202 PF02656.15 EMC84614.1 - 8.6 6.9 6.9 49 4.5 0.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF202) FapA PF03961.13 EMC84615.1 - 0.01 14.5 1.3 0.011 14.4 1.3 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A YqgF PF14639.6 EMC84615.1 - 0.019 14.8 0.1 0.022 14.5 0.1 1.2 1 0 0 1 1 1 0 Holliday-junction resolvase-like of SPT6 DivIVA PF05103.13 EMC84615.1 - 0.36 10.9 6.9 0.41 10.7 1.8 2.2 2 0 0 2 2 2 0 DivIVA protein MSG PF02349.15 EMC84615.1 - 0.43 10.8 6.3 3.2 8.0 1.1 2.4 2 1 0 2 2 2 0 Major surface glycoprotein CEP63 PF17045.5 EMC84616.1 - 0.023 14.6 43.9 0.02 14.8 21.0 3.1 3 1 0 3 3 3 0 Centrosomal protein of 63 kDa Fez1 PF06818.15 EMC84616.1 - 0.045 14.2 41.7 2.1 8.8 10.9 3.3 2 1 1 3 3 3 0 Fez1 EF-hand_1 PF00036.32 EMC84617.1 - 0.00081 18.8 0.5 0.00081 18.8 0.5 2.3 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.6 EMC84617.1 - 0.065 13.1 0.1 0.13 12.1 0.1 1.6 1 0 0 1 1 1 0 EF-hand domain pair Trypsin PF00089.26 EMC84618.1 - 6.1e-50 170.1 0.0 7.1e-50 169.9 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EMC84618.1 - 1.2e-06 29.5 0.0 1.6e-06 29.1 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 EMC84618.1 - 0.027 14.9 0.1 0.062 13.7 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1986) Peptidase_C14 PF00656.22 EMC84619.1 - 2.6e-49 168.4 0.0 3.2e-49 168.1 0.0 1.1 1 0 0 1 1 1 1 Caspase domain CARD PF00619.21 EMC84619.1 - 1.2e-05 25.3 0.0 2e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Caspase recruitment domain DnaJ PF00226.31 EMC84620.1 - 3.7e-11 43.0 0.6 9e-11 41.8 0.6 1.7 1 0 0 1 1 1 1 DnaJ domain Thioredoxin PF00085.20 EMC84620.1 - 7.8e-10 38.7 0.0 1.1e-06 28.5 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin IRK PF01007.20 EMC84620.1 - 0.034 14.0 0.0 0.067 13.0 0.0 1.4 1 0 0 1 1 1 0 Inward rectifier potassium channel transmembrane domain Thioredoxin_3 PF13192.6 EMC84620.1 - 0.093 12.8 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin domain Thioredoxin_2 PF13098.6 EMC84620.1 - 0.15 12.5 0.2 18 5.9 0.0 3.4 2 2 0 2 2 2 0 Thioredoxin-like domain Pkinase PF00069.25 EMC84621.1 - 5.3e-24 85.0 0.0 1.1e-23 83.9 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC84621.1 - 1.5e-13 50.6 0.0 4.3e-13 49.1 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC84621.1 - 0.0015 17.9 0.0 0.0028 17.0 0.0 1.4 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 EMC84621.1 - 0.018 14.9 0.2 0.043 13.7 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Beta-lactamase2 PF13354.6 EMC84621.1 - 0.19 11.3 0.1 0.33 10.5 0.1 1.3 1 0 0 1 1 1 0 Beta-lactamase enzyme family dCMP_cyt_deam_1 PF00383.23 EMC84622.1 - 3.2e-16 59.0 0.1 3.7e-16 58.9 0.1 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 EMC84622.1 - 2.7e-11 43.8 1.5 1.4e-08 35.0 0.2 2.1 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 EMC84622.1 - 0.0012 18.4 0.9 0.83 9.2 0.0 2.1 1 1 1 2 2 2 2 A distinct subfamily of CDD/CDA-like deaminases GIDE PF12483.8 EMC84623.1 - 6.8e-21 74.3 0.0 1.2e-20 73.5 0.0 1.4 1 0 0 1 1 1 1 E3 Ubiquitin ligase zf-C3HC4_3 PF13920.6 EMC84623.1 - 9.5e-13 47.8 14.7 1.8e-12 46.9 14.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC84623.1 - 7e-05 22.6 14.6 0.00013 21.8 14.6 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EMC84623.1 - 0.0012 19.1 15.3 0.0012 19.1 15.3 1.8 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 EMC84623.1 - 0.0015 18.5 14.6 0.0028 17.6 14.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain LapA_dom PF06305.11 EMC84623.1 - 0.042 13.7 0.1 0.084 12.7 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Peptidase_S49_N PF08496.10 EMC84623.1 - 0.045 13.8 0.0 0.083 13.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Vpu PF00558.19 EMC84623.1 - 0.045 13.5 0.0 0.084 12.7 0.0 1.4 1 0 0 1 1 1 0 Vpu protein zf-C3HC4_2 PF13923.6 EMC84623.1 - 0.11 12.4 14.6 0.21 11.5 14.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) VWA_3 PF13768.6 EMC84624.1 - 2.7e-29 102.1 0.0 5.2e-29 101.2 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EMC84624.1 - 1.1e-09 38.9 0.0 5.7e-09 36.6 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 EMC84624.1 - 2.6e-09 37.6 0.0 4e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain FIST PF08495.10 EMC84624.1 - 0.094 12.7 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 FIST N domain UBX PF00789.20 EMC84625.1 - 4.4e-09 36.4 0.0 7.2e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 UBX domain Phospholip_A2_1 PF00068.19 EMC84626.1 - 3.4e-36 124.1 6.0 4.2e-36 123.8 6.0 1.1 1 0 0 1 1 1 1 Phospholipase A2 Parvo_coat_N PF08398.10 EMC84626.1 - 0.17 12.1 0.0 0.27 11.4 0.0 1.3 1 0 0 1 1 1 0 Parvovirus coat protein VP1 BAMBI PF06211.12 EMC84626.1 - 0.17 12.1 6.8 0.8 10.0 0.7 2.3 2 0 0 2 2 2 0 BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain Phospholip_A2_2 PF05826.12 EMC84626.1 - 2.8 8.2 15.2 1.1e+02 3.2 15.2 2.3 1 1 0 1 1 1 0 Phospholipase A2 Phospholip_A2_1 PF00068.19 EMC84627.1 - 3.5e-30 104.7 10.6 3.9e-30 104.6 10.6 1.0 1 0 0 1 1 1 1 Phospholipase A2 Phospholip_A2_2 PF05826.12 EMC84627.1 - 0.00033 20.8 14.5 0.02 15.1 14.5 2.3 1 1 0 1 1 1 1 Phospholipase A2 Parvo_coat_N PF08398.10 EMC84627.1 - 0.019 15.1 0.1 0.06 13.5 0.0 1.8 1 1 1 2 2 2 0 Parvovirus coat protein VP1 OTU PF02338.19 EMC84628.1 - 2.2e-07 31.4 0.0 6.3e-07 29.9 0.0 1.8 1 0 0 1 1 1 1 OTU-like cysteine protease zf-RING_2 PF13639.6 EMC84629.1 - 5.9e-08 32.9 7.3 5.9e-08 32.9 7.3 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EMC84629.1 - 1.2e-06 28.2 8.0 3.4e-06 26.8 8.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC84629.1 - 2.7e-06 27.3 4.7 6.5e-06 26.1 4.7 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMC84629.1 - 4.9e-06 26.4 5.7 4.9e-06 26.4 5.7 1.9 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC84629.1 - 0.00021 21.0 5.1 0.00056 19.7 5.1 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EMC84629.1 - 0.0013 18.6 7.1 0.0013 18.6 7.1 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMC84629.1 - 0.0038 17.4 6.1 0.017 15.3 6.3 2.1 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EMC84629.1 - 0.017 14.9 2.1 0.017 14.9 2.1 2.8 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 EMC84629.1 - 0.032 14.0 0.3 0.032 14.0 0.3 2.7 3 0 0 3 3 3 0 RING-like zinc finger zf-rbx1 PF12678.7 EMC84629.1 - 0.047 14.0 7.6 0.18 12.1 7.6 2.1 1 1 0 1 1 1 0 RING-H2 zinc finger domain DUF2207 PF09972.9 EMC84629.1 - 0.15 10.8 0.1 0.19 10.5 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) TMEM208_SND2 PF05620.11 EMC84629.1 - 0.2 11.4 0.8 0.34 10.7 0.8 1.3 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 DUF3377 PF11857.8 EMC84629.1 - 2.5 8.1 9.3 1 9.4 1.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) DUF726 PF05277.12 EMC84630.1 - 9.7e-139 462.0 3.3 1.2e-138 461.7 3.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) LCAT PF02450.15 EMC84630.1 - 0.00053 19.3 0.0 0.00085 18.6 0.0 1.2 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF900 PF05990.12 EMC84630.1 - 0.00063 19.3 0.0 0.001 18.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) VirJ PF06057.11 EMC84630.1 - 0.014 15.3 0.0 0.072 13.0 0.0 2.0 2 0 0 2 2 2 0 Bacterial virulence protein (VirJ) Palm_thioest PF02089.15 EMC84630.1 - 0.017 14.9 0.0 0.026 14.4 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Sm_multidrug_ex PF06695.11 EMC84630.1 - 0.072 13.7 4.0 0.28 11.8 4.0 2.0 1 1 0 1 1 1 0 Putative small multi-drug export protein DUF3089 PF11288.8 EMC84630.1 - 0.13 11.8 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Thioesterase PF00975.20 EMC84630.1 - 0.18 11.9 0.0 0.42 10.7 0.0 1.5 1 0 0 1 1 1 0 Thioesterase domain 7tm_1 PF00001.21 EMC84631.1 - 7.6e-66 222.1 9.2 9.6e-66 221.8 9.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC84631.1 - 5.9e-06 25.8 4.8 5.9e-06 25.8 4.8 2.3 3 0 0 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC84631.1 - 2.3e-05 24.3 8.3 7e-05 22.7 7.8 1.9 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC84631.1 - 0.013 15.1 9.6 0.023 14.4 9.6 1.4 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx DUF1385 PF07136.11 EMC84631.1 - 0.1 11.8 0.4 0.46 9.7 0.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1385) DAN PF03045.15 EMC84632.1 - 2.4e-24 85.5 7.6 2.9e-24 85.3 7.6 1.0 1 0 0 1 1 1 1 DAN domain Cys_knot PF00007.22 EMC84632.1 - 4.5e-06 26.9 8.5 5.4e-06 26.6 8.5 1.1 1 0 0 1 1 1 1 Cystine-knot domain DUF543 PF04418.12 EMC84633.1 - 3.8e-15 55.6 1.2 3.8e-15 55.6 1.2 1.3 2 0 0 2 2 2 1 Domain of unknown function (DUF543) F_actin_cap_B PF01115.17 EMC84634.1 - 2.7e-110 367.7 0.0 3.2e-110 367.4 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit F-actin_cap_A PF01267.17 EMC84634.1 - 0.047 13.1 0.1 0.57 9.6 0.0 2.7 1 1 0 1 1 1 0 F-actin capping protein alpha subunit PQ-loop PF04193.14 EMC84635.1 - 4.1e-30 103.3 9.4 5.6e-18 64.5 1.1 2.6 2 0 0 2 2 2 2 PQ loop repeat MtN3_slv PF03083.16 EMC84635.1 - 0.018 15.1 8.2 0.13 12.4 0.2 2.4 2 0 0 2 2 2 0 Sugar efflux transporter for intercellular exchange CUT PF02376.15 EMC84635.1 - 0.12 12.5 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 CUT domain MARVEL PF01284.23 EMC84635.1 - 3.6 7.6 8.5 8.5 6.4 0.2 2.9 3 0 0 3 3 3 0 Membrane-associating domain Aldo_ket_red PF00248.21 EMC84636.1 - 6.9e-42 143.6 0.0 7.5e-42 143.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Trehalose_recp PF06151.13 EMC84636.1 - 0.2 10.2 0.0 0.25 9.9 0.0 1.1 1 0 0 1 1 1 0 Trehalose receptor EMC1_C PF07774.13 EMC84637.1 - 1.9e-70 236.9 0.2 4e-70 235.8 0.1 1.7 2 0 0 2 2 2 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 EMC84637.1 - 1.9e-10 40.7 0.2 4.6e-06 26.4 0.2 3.5 3 0 0 3 3 3 2 PQQ-like domain PQQ PF01011.21 EMC84637.1 - 8.1e-06 25.5 0.1 0.17 11.9 0.0 3.4 3 0 0 3 3 3 2 PQQ enzyme repeat Filament PF00038.21 EMC84638.1 - 2e-22 80.2 19.0 1.6e-11 44.4 10.4 2.1 2 0 0 2 2 2 2 Intermediate filament protein Rootletin PF15035.6 EMC84638.1 - 0.00089 19.3 2.8 0.00089 19.3 2.8 3.3 3 1 1 4 4 4 1 Ciliary rootlet component, centrosome cohesion Snapin_Pallidin PF14712.6 EMC84638.1 - 0.0038 17.6 1.8 0.0038 17.6 1.8 2.2 3 0 0 3 3 1 1 Snapin/Pallidin TPR_MLP1_2 PF07926.12 EMC84638.1 - 0.0062 16.6 3.1 0.0062 16.6 3.1 2.4 2 0 0 2 2 2 1 TPR/MLP1/MLP2-like protein FliJ PF02050.16 EMC84638.1 - 0.012 15.8 8.4 0.098 12.9 5.8 2.5 2 0 0 2 2 2 0 Flagellar FliJ protein APG6_N PF17675.1 EMC84638.1 - 0.028 15.0 3.6 0.028 15.0 3.6 2.8 2 1 0 2 2 2 0 Apg6 coiled-coil region HIN PF02760.15 EMC84638.1 - 0.042 13.6 0.1 0.081 12.6 0.1 1.4 1 0 0 1 1 1 0 HIN-200/IF120x domain CENP-F_leu_zip PF10473.9 EMC84638.1 - 0.21 11.6 15.9 0.14 12.2 7.7 2.9 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Occludin_ELL PF07303.13 EMC84638.1 - 0.24 12.2 5.0 1 10.1 0.4 3.1 2 1 0 2 2 2 0 Occludin homology domain CENP-H PF05837.12 EMC84638.1 - 0.58 10.6 8.2 0.39 11.1 1.2 3.0 3 0 0 3 3 3 0 Centromere protein H (CENP-H) Atg14 PF10186.9 EMC84638.1 - 0.79 8.7 9.4 1.8 7.5 9.4 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF87 PF01935.17 EMC84638.1 - 0.81 9.7 6.5 0.22 11.6 2.5 2.0 1 1 1 2 2 2 0 Helicase HerA, central domain TLE_N PF03920.15 EMC84638.1 - 1.1 9.4 5.8 0.27 11.3 0.3 2.6 2 1 0 2 2 2 0 Groucho/TLE N-terminal Q-rich domain DUF4407 PF14362.6 EMC84638.1 - 1.1 8.5 5.9 1.3 8.3 2.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) CdvA PF18822.1 EMC84638.1 - 1.2 9.0 11.4 0.32 10.8 4.1 2.8 3 0 0 3 3 3 0 CdvA-like coiled-coil domain TSNAXIP1_N PF15739.5 EMC84638.1 - 2.1 8.8 10.0 1.3 9.4 4.3 2.5 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus Prefoldin PF02996.17 EMC84638.1 - 2.8 7.9 9.7 7 6.6 0.2 3.0 2 1 0 2 2 2 0 Prefoldin subunit Mod_r PF07200.13 EMC84638.1 - 3.2 7.9 13.0 0.59 10.2 5.7 2.6 2 2 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein OmpH PF03938.14 EMC84638.1 - 4.6 7.6 13.6 2.5 8.4 7.7 2.6 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) FlaC_arch PF05377.11 EMC84638.1 - 4.7 7.7 7.9 12 6.4 3.3 3.4 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF724 PF05266.14 EMC84638.1 - 4.8 7.0 14.5 15 5.4 0.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF724) Tup_N PF08581.10 EMC84638.1 - 7.2 7.0 14.9 0.57 10.5 6.1 2.9 3 0 0 3 3 2 0 Tup N-terminal TMPIT PF07851.13 EMC84638.1 - 9.4 5.4 7.3 7.6 5.7 3.0 2.3 2 0 0 2 2 2 0 TMPIT-like protein PAX PF00292.18 EMC84639.1 - 2.6e-74 247.1 0.9 4e-74 246.5 0.9 1.3 1 0 0 1 1 1 1 'Paired box' domain Homeodomain PF00046.29 EMC84639.1 - 1.3e-23 82.6 7.0 3e-23 81.4 7.0 1.7 1 0 0 1 1 1 1 Homeodomain Pax7 PF12360.8 EMC84639.1 - 8.5e-20 70.7 6.7 2e-19 69.5 6.7 1.7 1 0 0 1 1 1 1 Paired box protein 7 Homeobox_KN PF05920.11 EMC84639.1 - 3.4e-05 23.7 0.8 0.0001 22.1 0.8 1.9 1 0 0 1 1 1 1 Homeobox KN domain HTH_32 PF13565.6 EMC84639.1 - 6.9e-05 23.4 6.0 0.0032 18.0 0.1 3.5 2 2 1 3 3 3 1 Homeodomain-like domain HTH_23 PF13384.6 EMC84639.1 - 0.00012 21.7 2.2 0.0014 18.4 0.1 2.5 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_IS1 PF12759.7 EMC84639.1 - 0.16 11.6 0.0 0.4 10.3 0.0 1.6 1 0 0 1 1 1 0 InsA C-terminal domain Kelch_1 PF01344.25 EMC84640.1 - 7e-21 73.5 9.9 2e-08 33.6 0.1 4.7 4 1 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 EMC84640.1 - 6.1e-19 67.6 4.2 1.4e-07 31.5 0.0 5.6 4 2 2 6 6 6 3 Kelch motif Kelch_4 PF13418.6 EMC84640.1 - 2.5e-06 27.4 1.3 0.43 10.6 0.0 3.9 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EMC84640.1 - 3e-06 27.0 4.5 0.11 12.5 0.0 4.1 4 1 0 4 4 4 3 Kelch motif FLYWCH PF04500.16 EMC84640.1 - 0.00054 20.0 0.2 0.0017 18.5 0.2 1.9 2 0 0 2 2 2 1 FLYWCH zinc finger domain Kelch_3 PF13415.6 EMC84640.1 - 0.0019 18.4 0.2 0.065 13.5 0.0 3.0 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC84640.1 - 0.049 13.6 1.0 0.58 10.2 0.1 2.9 3 0 0 3 3 3 0 Kelch motif Ig_3 PF13927.6 EMC84641.1 - 2.3e-05 24.9 0.0 4e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC84641.1 - 0.0002 21.6 0.0 0.00033 20.9 0.0 1.4 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC84641.1 - 0.0021 18.1 0.0 0.0031 17.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC84641.1 - 0.078 13.2 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Cytochrom_D1 PF02239.16 EMC84642.1 - 0.057 11.9 0.0 0.082 11.4 0.0 1.1 1 0 0 1 1 1 0 Cytochrome D1 heme domain Amelogenin PF02948.15 EMC84643.1 - 3.3e-06 27.9 48.3 0.061 14.0 18.6 3.6 1 1 2 3 3 3 3 Amelogenin DUF4573 PF15140.6 EMC84643.1 - 0.0018 18.1 20.9 0.0029 17.4 20.9 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4573) Collagen PF01391.18 EMC84644.1 - 7.6e-28 96.1 51.5 2.4e-07 30.4 16.9 4.0 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) PAD PF03068.15 EMC84645.1 - 1.2e-165 551.2 0.0 1.5e-165 551.0 0.0 1.1 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) PAD_M PF08527.10 EMC84645.1 - 3.6e-66 221.7 0.0 5.4e-66 221.1 0.0 1.3 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) middle domain PAD_N PF08526.10 EMC84645.1 - 4.3e-38 130.2 0.0 8.1e-38 129.3 0.0 1.5 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) N-terminal domain PAD PF03068.15 EMC84646.1 - 4.9e-94 315.5 0.6 4.3e-54 184.0 0.0 2.0 2 0 0 2 2 2 2 Protein-arginine deiminase (PAD) PAD_M PF08527.10 EMC84647.1 - 1.3e-19 70.4 0.2 3.8e-19 68.9 0.1 1.7 2 0 0 2 2 2 1 Protein-arginine deiminase (PAD) middle domain PAD_N PF08526.10 EMC84647.1 - 4.7e-19 68.8 0.0 6.1e-19 68.5 0.0 1.2 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) N-terminal domain CBM_4_9 PF02018.17 EMC84647.1 - 0.096 12.9 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 Carbohydrate binding domain DUF3553 PF12073.8 EMC84647.1 - 0.12 12.2 0.0 0.12 12.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3553) PAD PF03068.15 EMC84648.1 - 6.1e-113 377.7 0.0 6.8e-113 377.6 0.0 1.0 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) BpuJI_N PF11564.8 EMC84648.1 - 0.022 14.0 0.0 0.033 13.4 0.0 1.3 1 0 0 1 1 1 0 Restriction endonuclease BpuJI - N terminal Fer2_3 PF13085.6 EMC84649.1 - 2.9e-32 110.9 0.0 5.1e-32 110.1 0.0 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 EMC84649.1 - 0.0002 21.8 1.1 0.0002 21.8 1.1 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EMC84649.1 - 0.00046 20.6 5.2 0.0012 19.3 5.2 1.7 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 EMC84649.1 - 0.0063 16.6 0.2 0.0063 16.6 0.2 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 EMC84649.1 - 0.0067 16.4 3.0 0.011 15.6 0.2 2.2 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain E1-E2_ATPase PF00122.20 EMC84650.1 - 6e-37 126.9 0.1 1.6e-36 125.5 0.0 1.6 1 1 1 2 2 2 1 E1-E2 ATPase Cation_ATPase_N PF00690.26 EMC84650.1 - 0.00044 19.9 0.1 0.0012 18.5 0.1 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus LptF_LptG PF03739.14 EMC84650.1 - 0.034 13.0 1.6 0.057 12.3 1.6 1.3 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG Hydrolase PF00702.26 EMC84650.1 - 0.24 11.7 0.0 0.37 11.0 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase MARVEL PF01284.23 EMC84650.1 - 0.4 10.7 7.3 0.092 12.8 0.5 2.3 2 1 0 2 2 2 0 Membrane-associating domain Rootletin PF15035.6 EMC84651.1 - 1e-23 84.3 13.4 1e-23 84.3 13.4 2.8 2 1 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion DcrB PF08786.11 EMC84651.1 - 0.1 12.7 4.4 0.16 12.0 4.4 1.4 1 0 0 1 1 1 0 DcrB WXG100 PF06013.12 EMC84651.1 - 0.25 11.6 0.2 0.25 11.6 0.2 3.5 3 2 0 3 3 3 0 Proteins of 100 residues with WXG ERM PF00769.19 EMC84651.1 - 2.7 7.8 29.7 4.1 7.2 29.7 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family PRKCSH-like PF12999.7 EMC84651.1 - 3.8 7.3 8.9 1.3 8.8 0.3 2.2 2 0 0 2 2 2 0 Glucosidase II beta subunit-like FapA PF03961.13 EMC84651.1 - 5 5.6 12.3 6.6 5.2 12.3 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A Methyltransf_14 PF08484.11 EMC84651.1 - 9.5 6.0 8.1 3.7 7.3 3.6 2.4 1 1 2 3 3 3 0 C-methyltransferase C-terminal domain DUF1681 PF07933.14 EMC84652.1 - 2.4e-41 140.9 0.0 3e-41 140.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) SUZ PF12752.7 EMC84653.1 - 8.3e-13 48.9 0.1 8.3e-13 48.9 0.1 2.6 3 0 0 3 3 3 1 SUZ domain SUZ-C PF12901.7 EMC84653.1 - 5.6e-09 35.9 4.0 1e-08 35.0 4.0 1.5 1 0 0 1 1 1 1 SUZ-C motif Pkinase_Tyr PF07714.17 EMC84655.1 - 3.7e-98 327.9 0.0 4.4e-98 327.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC84655.1 - 1.1e-48 165.9 0.0 1.4e-48 165.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain EphA2_TM PF14575.6 EMC84655.1 - 3.3e-14 53.5 0.3 5.7e-14 52.8 0.3 1.4 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Haspin_kinase PF12330.8 EMC84655.1 - 0.00099 18.1 0.1 0.0052 15.8 0.0 1.8 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 EMC84655.1 - 0.098 12.0 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Auxin_inducible PF02519.14 EMC84655.1 - 0.15 12.2 0.0 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 Auxin responsive protein ABC1 PF03109.16 EMC84655.1 - 0.18 12.0 0.0 0.35 11.1 0.0 1.4 1 0 0 1 1 1 0 ABC1 family Pkinase_fungal PF17667.1 EMC84655.1 - 0.2 10.4 0.0 0.31 9.7 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase HSP20 PF00011.21 EMC84656.1 - 1.9e-16 60.1 0.0 2.4e-16 59.8 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EMC84656.1 - 0.0055 16.2 0.0 0.0071 15.9 0.0 1.1 1 0 0 1 1 1 1 HSP20-like domain found in ArsA TMEM82 PF15816.5 EMC84658.1 - 6.6e-106 353.8 14.4 7.4e-106 353.6 14.4 1.0 1 0 0 1 1 1 1 Transmembrane protein 82 Cyt_c_ox_IV PF12270.8 EMC84658.1 - 1.8 8.7 0.0 1.8 8.7 0.0 2.8 2 1 0 2 2 2 0 Cytochrome c oxidase subunit IV PH PF00169.29 EMC84659.1 - 2.6e-15 56.8 0.6 2.9e-12 47.0 0.0 2.8 3 0 0 3 3 3 2 PH domain PH_9 PF15410.6 EMC84659.1 - 0.00035 20.9 0.0 0.097 13.0 0.0 2.8 3 0 0 3 3 3 2 Pleckstrin homology domain HEPN_SAV2148 PF18725.1 EMC84659.1 - 0.065 12.6 0.1 8.8 5.7 0.0 2.5 2 0 0 2 2 2 0 SAV2148-like HEPN bPH_3 PF14470.6 EMC84659.1 - 0.16 12.4 0.3 3.7 8.0 0.0 2.7 2 2 0 2 2 2 0 Bacterial PH domain SET PF00856.28 EMC84661.1 - 4.4e-17 63.0 0.1 5.2e-17 62.8 0.1 1.1 1 0 0 1 1 1 1 SET domain HAT_KAT11 PF08214.11 EMC84662.1 - 9.3e-69 232.3 0.5 9.3e-69 232.3 0.5 1.7 2 0 0 2 2 2 1 Histone acetylation protein KIX PF02172.16 EMC84662.1 - 2.5e-40 136.6 0.8 8.7e-40 134.9 0.8 2.0 1 0 0 1 1 1 1 KIX domain Creb_binding PF09030.10 EMC84662.1 - 1.7e-34 118.7 19.0 1.7e-34 118.7 19.0 12.9 7 3 6 13 13 13 1 Creb binding zf-TAZ PF02135.16 EMC84662.1 - 1.4e-28 99.1 70.6 8.5e-19 67.8 20.6 3.7 3 0 0 3 3 3 2 TAZ zinc finger DUF902 PF06001.13 EMC84662.1 - 3.8e-22 78.5 9.2 3.8e-22 78.5 9.2 2.3 2 0 0 2 2 2 1 Domain of Unknown Function (DUF902) Bromodomain PF00439.25 EMC84662.1 - 5.6e-17 61.6 0.0 1.4e-16 60.3 0.0 1.7 1 0 0 1 1 1 1 Bromodomain ZZ PF00569.17 EMC84662.1 - 1.5e-15 56.8 14.6 1.5e-15 56.8 14.6 3.3 3 0 0 3 3 3 1 Zinc finger, ZZ type KIX_2 PF16987.5 EMC84662.1 - 1.8e-05 24.6 0.2 8.7e-05 22.4 0.2 2.3 1 0 0 1 1 1 1 KIX domain Npa1 PF11707.8 EMC84662.1 - 0.0056 16.1 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal HSP90 PF00183.18 EMC84663.1 - 3.2e-101 339.8 6.2 5.5e-96 322.5 2.2 2.2 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.6 EMC84663.1 - 2.1e-11 43.8 0.0 8e-11 41.9 0.0 2.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EMC84663.1 - 1.5e-08 35.2 0.1 2.9e-08 34.2 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Slx4 PF09494.10 EMC84664.1 - 6.5e-16 58.0 0.0 9.6e-16 57.5 0.0 1.3 1 0 0 1 1 1 1 Slx4 endonuclease SAP PF02037.27 EMC84664.1 - 0.18 11.6 0.6 1.9 8.3 0.2 2.2 2 0 0 2 2 2 0 SAP domain zf-H2C2_2 PF13465.6 EMC84665.1 - 4.1e-79 257.7 66.3 1.9e-10 40.7 1.3 10.7 11 0 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.26 EMC84665.1 - 3.3e-63 206.8 65.9 2.6e-07 30.7 0.5 10.2 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC84665.1 - 7.5e-38 125.9 65.5 0.001 19.7 0.6 10.1 10 0 0 10 10 10 10 C2H2-type zinc finger zf_UBZ PF18439.1 EMC84665.1 - 1.8e-19 69.0 36.0 0.072 12.7 0.1 10.1 10 0 0 10 10 10 7 Ubiquitin-Binding Zinc Finger zf-C2H2_6 PF13912.6 EMC84665.1 - 4.9e-16 58.3 66.5 0.00034 20.5 0.6 12.1 10 3 0 10 10 10 6 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 EMC84665.1 - 2.3e-13 50.0 45.6 0.015 15.4 2.3 8.2 4 3 5 9 9 9 8 Zinc ribbon domain zf-C2H2_jaz PF12171.8 EMC84665.1 - 1.4e-12 47.5 21.2 0.051 13.9 0.1 8.9 9 0 0 9 9 9 2 Zinc-finger double-stranded RNA-binding XPA_N PF01286.18 EMC84665.1 - 1.9e-10 40.6 36.8 2.4 8.3 0.2 10.1 10 0 0 10 10 10 3 XPA protein N-terminal DNA_RNApol_7kD PF03604.13 EMC84665.1 - 6.6e-10 38.5 33.2 1.8 8.3 0.3 10.1 10 0 0 10 10 10 3 DNA directed RNA polymerase, 7 kDa subunit zinc_ribbon_4 PF13717.6 EMC84665.1 - 4.5e-09 36.1 30.1 0.79 9.7 1.7 9.1 6 4 0 6 6 6 3 zinc-ribbon domain zf-LYAR PF08790.11 EMC84665.1 - 4.9e-09 35.9 39.0 1.7 8.6 0.3 10.2 10 0 0 10 10 10 3 LYAR-type C2HC zinc finger zf-trcl PF13451.6 EMC84665.1 - 8.2e-09 35.2 36.7 1.6 8.7 4.6 9.8 9 1 0 9 9 9 3 Probable zinc-ribbon domain CpXC PF14353.6 EMC84665.1 - 1.7e-08 34.5 24.4 4 7.5 0.6 9.5 2 2 6 9 9 9 1 CpXC protein ADK_lid PF05191.14 EMC84665.1 - 3.3e-08 33.4 23.5 0.029 14.3 0.4 7.1 5 3 2 7 7 7 3 Adenylate kinase, active site lid C1_1 PF00130.22 EMC84665.1 - 9.5e-08 31.8 33.6 0.2 11.6 1.3 8.1 1 1 9 10 10 10 6 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn_ribbon_recom PF13408.6 EMC84665.1 - 1.6e-06 28.6 32.2 2.4 8.7 0.1 8.3 4 3 5 9 9 9 2 Recombinase zinc beta ribbon domain zf-C2H2_11 PF16622.5 EMC84665.1 - 1.7e-06 27.6 58.7 0.094 12.5 0.3 9.9 10 0 0 10 10 10 6 zinc-finger C2H2-type zinc_ribbon_15 PF17032.5 EMC84665.1 - 2.1e-06 28.4 29.5 0.17 12.6 1.1 5.6 1 1 6 7 7 7 4 zinc-ribbon family FYDLN_acid PF09538.10 EMC84665.1 - 2.5e-06 28.1 18.9 16 6.2 0.0 8.9 1 1 8 9 9 9 0 Protein of unknown function (FYDLN_acid) TFIIS_C PF01096.18 EMC84665.1 - 1.1e-05 25.2 35.6 9.5 6.2 0.2 9.6 9 1 0 9 9 9 0 Transcription factor S-II (TFIIS) DUF3268 PF11672.8 EMC84665.1 - 1.2e-05 25.7 21.9 0.52 10.7 0.0 5.2 3 1 0 5 5 5 2 zinc-finger-containing domain zf-AN1 PF01428.16 EMC84665.1 - 2.3e-05 24.4 41.8 5.2 7.3 0.2 10.0 9 1 1 10 10 10 0 AN1-like Zinc finger C1_4 PF07975.12 EMC84665.1 - 0.00012 22.2 36.7 0.12 12.6 3.5 6.8 1 1 5 8 8 8 4 TFIIH C1-like domain LIM PF00412.22 EMC84665.1 - 0.00022 21.4 35.8 1.5 9.1 1.3 7.7 2 2 6 8 8 8 3 LIM domain HypA PF01155.19 EMC84665.1 - 0.00034 20.6 29.2 1.6 8.8 1.4 5.9 1 1 6 7 7 7 5 Hydrogenase/urease nickel incorporation, metallochaperone, hypA YhfH PF14149.6 EMC84665.1 - 0.00069 19.5 37.7 8.6 6.4 0.2 9.8 10 0 0 10 10 10 0 YhfH-like protein FAM178 PF14816.6 EMC84665.1 - 0.0013 17.8 2.9 7.6 5.4 0.0 4.4 1 1 3 5 5 5 0 Family of unknown function, FAM178 Zn_Tnp_IS1595 PF12760.7 EMC84665.1 - 0.0046 16.9 51.8 0.094 12.7 3.5 7.2 4 3 3 8 8 8 2 Transposase zinc-ribbon domain Elf1 PF05129.13 EMC84665.1 - 0.0078 16.2 30.2 0.84 9.7 0.9 6.0 1 1 5 6 6 6 3 Transcription elongation factor Elf1 like zf_C2H2_ZHX PF18387.1 EMC84665.1 - 0.011 15.3 41.8 1.2 8.8 0.2 9.3 1 1 9 10 10 10 0 Zinc-fingers and homeoboxes C2H2 finger domain zinc-ribbons_6 PF07191.12 EMC84665.1 - 0.025 14.5 32.8 0.93 9.5 0.2 7.1 2 1 0 2 2 1 0 zinc-ribbons zf-met PF12874.7 EMC84665.1 - 0.057 13.8 0.5 0.057 13.8 0.5 9.6 10 0 0 10 10 9 0 Zinc-finger of C2H2 type DUF3656 PF12392.8 EMC84665.1 - 0.068 13.8 0.0 19 5.9 0.0 4.2 1 1 2 3 3 3 0 Collagenase DUF2256 PF10013.9 EMC84665.1 - 1.1 9.5 27.2 12 6.1 0.2 8.8 10 0 0 10 10 9 0 Uncharacterized protein conserved in bacteria (DUF2256) HalOD2 PF18547.1 EMC84665.1 - 3.2 7.7 35.8 0.58 10.1 0.8 8.0 5 3 2 7 7 7 0 Halobacterial output domain 2 Scramblase PF03803.15 EMC84665.1 - 3.9 6.7 4.7 12 5.2 0.2 2.6 1 1 1 3 3 3 0 Scramblase Yippee-Mis18 PF03226.14 EMC84665.1 - 6.8 7.0 26.7 3.3 8.0 1.0 6.3 3 2 3 6 6 6 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF2072 PF09845.9 EMC84665.1 - 8 6.7 34.9 7.1 6.9 0.2 8.1 9 1 0 9 9 8 0 Zn-ribbon containing protein zf-C2HE PF16278.5 EMC84665.1 - 9 6.8 46.6 19 5.8 0.5 9.3 1 1 8 9 9 8 0 C2HE / C2H2 / C2HC zinc-binding finger Peptidase_M30 PF10460.9 EMC84666.1 - 0.068 12.1 0.1 0.1 11.5 0.1 1.3 2 0 0 2 2 2 0 Peptidase M30 Heme_oxygenase PF01126.20 EMC84667.1 - 1.9e-83 279.3 5.5 2.3e-83 279.0 5.5 1.1 1 0 0 1 1 1 1 Heme oxygenase zf-LITAF-like PF10601.9 EMC84668.1 - 8.2e-24 83.7 16.7 1.1e-23 83.2 16.7 1.2 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain zf-C3HC4_3 PF13920.6 EMC84671.1 - 1.8e-14 53.3 9.4 2.8e-14 52.7 9.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC84671.1 - 8.9e-07 28.7 10.2 1.6e-06 27.9 10.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EMC84671.1 - 7.5e-06 26.2 11.7 1.3e-05 25.4 11.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EMC84671.1 - 0.00048 20.0 9.5 0.00089 19.2 9.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EMC84671.1 - 0.0017 18.2 11.3 0.003 17.4 11.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 EMC84671.1 - 1.9 8.4 8.3 3.3 7.6 8.3 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-P11 PF03854.14 EMC84671.1 - 8.3 6.2 13.0 23 4.7 13.0 1.8 1 1 0 1 1 1 0 P-11 zinc finger DUF4507 PF14964.6 EMC84673.1 - 1.5e-128 428.7 0.5 1.8e-128 428.5 0.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4507) Exo_endo_phos PF03372.23 EMC84674.1 - 1.2e-09 38.0 0.0 1.5e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos PF03372.23 EMC84675.1 - 2.1e-09 37.2 0.0 2.7e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family ECH_1 PF00378.20 EMC84676.1 - 1.7e-74 250.3 0.0 1.9e-74 250.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EMC84676.1 - 2e-14 53.9 0.0 2.7e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase YwhD PF08741.10 EMC84676.1 - 0.058 13.1 0.3 0.11 12.2 0.3 1.4 1 0 0 1 1 1 0 YwhD family Voltage_CLC PF00654.20 EMC84677.1 - 2.3e-97 326.5 27.1 1.1e-96 324.2 24.6 2.0 2 0 0 2 2 2 2 Voltage gated chloride channel FAM181 PF15238.6 EMC84678.1 - 6.2e-06 26.3 0.2 7.2e-06 26.0 0.2 1.1 1 0 0 1 1 1 1 FAM181 LUC7 PF03194.15 EMC84679.1 - 3.7e-72 243.0 13.5 3.7e-72 243.0 13.5 2.2 1 1 1 2 2 2 1 LUC7 N_terminus TSC22 PF01166.18 EMC84679.1 - 0.49 10.8 3.8 8.8 6.7 0.2 2.9 2 1 1 3 3 3 0 TSC-22/dip/bun family PQQ_2 PF13360.6 EMC84680.1 - 0.0029 17.2 0.3 1.8 8.1 0.1 2.7 2 1 0 2 2 2 2 PQQ-like domain FG-GAP PF01839.23 EMC84680.1 - 0.0064 16.6 0.1 0.39 10.9 0.1 2.5 2 0 0 2 2 2 1 FG-GAP repeat VCBS PF13517.6 EMC84680.1 - 0.14 12.8 0.1 4.7 7.9 0.0 2.7 3 0 0 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DUF3413 PF11893.8 EMC84680.1 - 0.14 11.3 0.3 0.2 10.8 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) CSD PF00313.22 EMC84682.1 - 1.6e-13 50.3 0.0 2.1e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 EMC84682.1 - 0.02 14.6 0.0 0.032 13.9 0.0 1.5 1 0 0 1 1 1 0 Ribonuclease B OB domain Herpes_pp85 PF04637.12 EMC84682.1 - 3.7 5.9 6.9 5.1 5.4 6.9 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) PMM PF03332.13 EMC84683.1 - 1.6e-105 351.7 0.9 1.9e-105 351.5 0.9 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase DUF600 PF04634.12 EMC84683.1 - 0.15 12.1 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF600 TMEM223 PF14640.6 EMC84684.1 - 4.2e-05 23.8 0.1 4.8e-05 23.6 0.1 1.1 1 0 0 1 1 1 1 Transmembrane protein 223 Aminotran_3 PF00202.21 EMC84685.1 - 8.2e-135 449.6 0.0 9.4e-135 449.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Methyltransf_16 PF10294.9 EMC84686.1 - 4.6e-21 75.3 0.6 3e-19 69.4 0.6 2.2 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 EMC84686.1 - 0.028 15.1 0.1 0.084 13.6 0.1 2.0 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EMC84686.1 - 0.028 14.2 0.0 0.056 13.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 EMC84686.1 - 0.089 12.2 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF2321 PF10083.9 EMC84686.1 - 0.14 11.7 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) Claudin_2 PF13903.6 EMC84687.1 - 4.2e-21 75.6 7.8 5.1e-21 75.3 7.8 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 EMC84687.1 - 2.1e-11 43.9 2.8 3.4e-11 43.3 2.8 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family AA_permease_C PF13906.6 EMC84687.1 - 1 9.5 9.3 0.27 11.3 4.4 2.2 2 0 0 2 2 2 0 C-terminus of AA_permease PsbN PF02468.15 EMC84687.1 - 2.3 8.2 5.5 1 9.2 2.3 2.1 1 1 2 3 3 3 0 Photosystem II reaction centre N protein (psbN) Fox-1_C PF12414.8 EMC84688.1 - 1.9e-43 146.7 22.8 1.9e-43 146.7 22.8 2.7 3 1 0 3 3 3 1 Calcitonin gene-related peptide regulator C terminal RRM_1 PF00076.22 EMC84688.1 - 1.5e-18 66.3 0.1 3.4e-18 65.2 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPESP1 PF15754.5 EMC84688.1 - 0.0061 15.8 3.7 0.0091 15.2 3.7 1.2 1 0 0 1 1 1 1 Sperm equatorial segment protein 1 RRM_5 PF13893.6 EMC84688.1 - 0.054 13.1 0.0 0.097 12.3 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Tissue_fac PF01108.17 EMC84689.1 - 2.6e-21 75.5 0.1 1.7e-20 72.8 0.0 2.3 3 0 0 3 3 3 1 Tissue factor Interfer-bind PF09294.10 EMC84689.1 - 1.3e-10 41.6 0.5 3.6e-10 40.1 0.5 1.8 1 1 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.21 EMC84689.1 - 0.00024 21.4 0.2 0.6 10.5 0.1 2.6 2 1 0 2 2 2 2 Fibronectin type III domain GSG-1 PF07803.11 EMC84690.1 - 4.6e-52 174.8 0.8 8.2e-52 174.0 0.8 1.4 1 0 0 1 1 1 1 GSG1-like protein PMP22_Claudin PF00822.20 EMC84690.1 - 3.1e-08 33.7 11.1 1.8e-05 24.7 11.1 2.5 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC84690.1 - 2.3e-05 24.2 13.4 0.0001 22.1 13.2 2.2 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Rhomboid_SP PF12595.8 EMC84691.1 - 3.2e-113 376.4 1.7 4.7e-113 375.9 1.7 1.2 1 0 0 1 1 1 1 Rhomboid serine protease Rhomboid PF01694.22 EMC84691.1 - 7.9e-28 97.3 9.1 7.9e-28 97.3 9.1 1.8 2 0 0 2 2 2 1 Rhomboid family Herpes_UL56 PF04534.12 EMC84691.1 - 0.022 14.2 0.9 0.034 13.6 0.1 1.7 2 0 0 2 2 2 0 Herpesvirus UL56 protein Pur_DNA_glyco PF02245.16 EMC84692.1 - 3.1e-60 202.6 0.0 3.8e-60 202.3 0.0 1.1 1 0 0 1 1 1 1 Methylpurine-DNA glycosylase (MPG) NPR3 PF03666.13 EMC84693.1 - 1.4e-38 132.9 8.7 7.2e-30 104.2 7.9 3.1 1 1 1 2 2 2 2 Nitrogen Permease regulator of amino acid transport activity 3 NPR2 PF06218.11 EMC84693.1 - 0.0007 18.5 0.2 0.0092 14.8 0.2 2.2 1 1 0 1 1 1 1 Nitrogen permease regulator 2 Globin PF00042.22 EMC84694.1 - 4.6e-29 101.2 0.0 6.8e-29 100.7 0.0 1.2 1 0 0 1 1 1 1 Globin Globin PF00042.22 EMC84696.1 - 3.1e-25 88.9 0.1 6e-25 87.9 0.0 1.5 2 0 0 2 2 2 1 Globin Globin PF00042.22 EMC84697.1 - 2.1e-28 99.1 0.0 2.8e-28 98.7 0.0 1.2 1 0 0 1 1 1 1 Globin DIX PF00778.17 EMC84699.1 - 2.6e-31 107.3 1.1 4.6e-31 106.5 1.1 1.4 1 0 0 1 1 1 1 DIX domain RGS PF00615.19 EMC84699.1 - 1.4e-27 96.3 0.4 2.9e-27 95.3 0.4 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain AXIN1_TNKS_BD PF16646.5 EMC84699.1 - 9.1e-26 90.6 3.7 6e-25 88.0 3.7 2.6 1 0 0 1 1 1 1 Axin-1 tankyrase binding domain Axin_b-cat_bind PF08833.10 EMC84699.1 - 8e-11 41.9 0.0 3e-10 40.0 0.0 2.1 1 0 0 1 1 1 1 Axin beta-catenin binding domain Cwf_Cwc_15 PF04889.12 EMC84699.1 - 0.3 10.8 4.5 0.44 10.2 1.0 2.5 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Thioredoxin_6 PF13848.6 EMC84700.1 - 1.7e-39 135.6 0.0 1.8e-32 112.8 0.0 3.1 3 0 0 3 3 3 3 Thioredoxin-like domain Thioredoxin PF00085.20 EMC84700.1 - 4.1e-30 103.8 0.0 1.5e-21 76.3 0.1 3.2 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_2 PF13098.6 EMC84700.1 - 1.3e-07 32.1 0.0 0.0044 17.5 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EMC84700.1 - 3.3e-05 23.4 0.1 0.68 9.2 0.0 3.2 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 EMC84700.1 - 0.0002 21.5 0.0 0.0014 18.8 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_8 PF13905.6 EMC84700.1 - 0.00025 21.3 0.0 0.0085 16.4 0.0 2.5 2 0 0 2 2 2 1 Thioredoxin-like AhpC-TSA PF00578.21 EMC84700.1 - 0.013 15.4 0.0 0.044 13.7 0.1 1.8 2 0 0 2 2 2 0 AhpC/TSA family HyaE PF07449.11 EMC84700.1 - 0.093 12.7 0.1 8.4 6.4 0.0 3.2 3 1 1 4 4 4 0 Hydrogenase-1 expression protein HyaE NMDAR2_C PF10565.9 EMC84701.1 - 3.9e-273 908.3 34.6 4.7e-273 908.1 34.6 1.1 1 0 0 1 1 1 1 N-methyl D-aspartate receptor 2B3 C-terminus Lig_chan PF00060.26 EMC84701.1 - 1.2e-34 119.3 1.7 1.9e-34 118.7 0.1 2.2 3 0 0 3 3 3 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 EMC84701.1 - 2.3e-30 105.1 0.1 1.2e-29 102.9 0.1 2.1 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 EMC84701.1 - 4.4e-21 75.4 0.0 1.3e-20 73.8 0.0 1.8 2 0 0 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 ANF_receptor PF01094.28 EMC84701.1 - 9e-11 41.5 1.4 3.9e-10 39.4 1.4 2.0 1 1 0 1 1 1 1 Receptor family ligand binding region Cript PF10235.9 EMC84701.1 - 0.37 11.4 5.2 0.17 12.5 0.4 2.6 2 0 0 2 2 2 0 Microtubule-associated protein CRIPT PMP22_Claudin PF00822.20 EMC84702.1 - 5.1e-49 166.3 16.3 5.8e-49 166.2 16.3 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC84702.1 - 1.8e-08 34.4 9.5 1.8e-08 34.4 9.5 2.1 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction Amastin PF07344.11 EMC84702.1 - 0.026 14.4 15.1 0.063 13.1 14.8 1.8 1 1 0 1 1 1 0 Amastin surface glycoprotein Claudin_3 PF06653.11 EMC84702.1 - 0.41 10.6 18.1 1.2 9.0 18.1 1.7 1 1 0 1 1 1 0 Tight junction protein, Claudin-like SUR7 PF06687.12 EMC84702.1 - 1.4 8.5 34.3 0.066 12.8 16.5 3.7 1 1 1 2 2 2 0 SUR7/PalI family Tektin PF03148.14 EMC84703.1 - 9.4e-142 472.3 23.7 1.1e-141 472.1 23.7 1.0 1 0 0 1 1 1 1 Tektin family Vps23_core PF09454.10 EMC84703.1 - 0.00012 21.9 0.7 0.16 12.0 0.1 2.6 2 0 0 2 2 2 2 Vps23 core domain JIP_LZII PF16471.5 EMC84703.1 - 3.1 8.0 14.6 2.1 8.6 0.3 4.0 4 0 0 4 4 4 0 JNK-interacting protein leucine zipper II TBCA PF02970.16 EMC84703.1 - 3.9 7.9 18.7 7 7.1 0.2 4.2 3 2 1 4 4 4 0 Tubulin binding cofactor A ParA PF10609.9 EMC84704.1 - 1.7e-86 289.6 0.0 2e-86 289.5 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase AAA_26 PF13500.6 EMC84704.1 - 0.029 14.2 0.0 0.038 13.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain PcrB PF01884.17 EMC84704.1 - 0.066 12.7 0.0 0.096 12.1 0.0 1.2 1 0 0 1 1 1 0 PcrB family AAA_31 PF13614.6 EMC84704.1 - 0.09 12.7 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain Fer4_NifH PF00142.18 EMC84704.1 - 0.099 12.1 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family TF_Zn_Ribbon PF08271.12 EMC84704.1 - 0.11 12.1 0.1 0.25 10.9 0.1 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding DUF846 PF05832.12 EMC84705.1 - 5.6e-53 178.7 14.0 6.5e-53 178.5 14.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) NACHT PF05729.12 EMC84707.1 - 2.7e-24 86.0 0.0 5.9e-24 84.9 0.0 1.6 1 0 0 1 1 1 1 NACHT domain LRR_6 PF13516.6 EMC84707.1 - 5.2e-14 51.0 11.3 3.1e-05 23.7 0.1 5.5 5 1 0 5 5 5 3 Leucine Rich repeat NLRC4_HD2 PF17776.1 EMC84707.1 - 7.7e-13 49.1 1.4 4.6e-12 46.6 1.4 2.4 1 0 0 1 1 1 1 NLRC4 helical domain HD2 LRR_4 PF12799.7 EMC84707.1 - 1.1e-09 38.4 10.3 2.9e-06 27.5 1.1 4.9 4 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC84707.1 - 3.7e-06 26.5 1.0 0.0017 17.9 0.2 3.0 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 EMC84707.1 - 8.4e-06 25.5 8.5 0.012 15.4 3.2 4.7 3 1 1 4 4 4 2 Leucine rich repeat LRR_1 PF00560.33 EMC84707.1 - 0.00014 21.9 2.1 20 6.2 0.0 5.8 5 0 0 5 5 5 0 Leucine Rich Repeat UreE_C PF05194.12 EMC84707.1 - 0.038 14.5 0.1 0.25 11.8 0.0 2.1 2 0 0 2 2 2 0 UreE urease accessory protein, C-terminal domain LRR_2 PF07723.13 EMC84707.1 - 0.09 13.5 3.1 6.9 7.5 0.0 4.4 4 0 0 4 4 4 0 Leucine Rich Repeat Dexa_ind PF15198.6 EMC84708.1 - 2.2e-43 146.3 10.3 2.4e-43 146.1 10.3 1.0 1 0 0 1 1 1 1 Dexamethasone-induced FPL PF09758.9 EMC84709.1 - 3.9e-57 192.4 10.1 7.6e-57 191.5 10.1 1.5 1 0 0 1 1 1 1 Uncharacterised conserved protein SH2 PF00017.24 EMC84710.1 - 1.8e-10 40.8 0.0 3.9e-10 39.7 0.0 1.6 2 0 0 2 2 2 1 SH2 domain SOCS_box PF07525.16 EMC84710.1 - 6.6e-09 36.0 0.1 1.3e-08 35.0 0.1 1.5 1 0 0 1 1 1 1 SOCS box RMI2 PF16100.5 EMC84711.1 - 2e-10 40.6 0.0 4.8e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 RecQ-mediated genome instability protein 2 zf-LITAF-like PF10601.9 EMC84714.1 - 1.6e-27 95.5 5.4 2.1e-27 95.2 5.4 1.1 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain zf-ACC PF17848.1 EMC84714.1 - 0.0072 16.4 1.7 0.42 10.7 0.1 2.5 2 0 0 2 2 2 2 Acetyl-coA carboxylase zinc finger domain zf-C4_Topoisom PF01396.19 EMC84714.1 - 0.015 15.1 0.9 1.4 8.7 0.1 2.5 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger zf-RING_7 PF02591.15 EMC84714.1 - 0.046 13.9 2.9 1 9.6 0.2 2.5 2 0 0 2 2 2 0 C4-type zinc ribbon domain SNN_transmemb PF09049.10 EMC84715.1 - 1.7e-21 75.8 8.8 2.2e-21 75.4 8.8 1.1 1 0 0 1 1 1 1 Stannin transmembrane SNN_cytoplasm PF09051.10 EMC84715.1 - 5.1e-21 74.2 0.4 6.7e-21 73.8 0.4 1.2 1 0 0 1 1 1 1 Stannin cytoplasmic SNN_linker PF09050.10 EMC84715.1 - 2.1e-20 72.1 2.8 2.9e-20 71.7 2.8 1.2 1 0 0 1 1 1 1 Stannin unstructured linker DUF5337 PF17272.2 EMC84715.1 - 0.031 14.1 0.0 0.041 13.7 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5337) LapA_dom PF06305.11 EMC84715.1 - 0.062 13.1 0.1 0.085 12.7 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF202 PF02656.15 EMC84715.1 - 0.11 13.0 0.6 0.14 12.6 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF202) OST-HTH PF12872.7 EMC84716.1 - 1.6e-67 223.2 0.4 2.4e-13 49.7 0.0 8.4 8 0 0 8 8 8 6 OST-HTH/LOTUS domain Limkain-b1 PF11608.8 EMC84716.1 - 6.6e-41 138.3 0.3 1.6e-40 137.0 0.3 1.7 1 0 0 1 1 1 1 Limkain b1 NYN PF01936.18 EMC84716.1 - 1.2e-18 68.0 0.0 2.8e-18 66.8 0.0 1.7 1 0 0 1 1 1 1 NYN domain RRM_1 PF00076.22 EMC84716.1 - 2.8e-09 36.7 0.0 2.4e-05 24.1 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMC84716.1 - 0.00063 19.3 0.1 1.7 8.2 0.0 2.9 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NUDE_C PF04880.13 EMC84717.1 - 5.7e-43 147.5 3.6 5.7e-43 147.5 3.6 2.4 2 0 0 2 2 2 1 NUDE protein, C-terminal conserved region DMPK_coil PF08826.10 EMC84717.1 - 0.0027 17.8 8.0 0.0027 17.8 8.0 4.0 2 1 1 3 3 3 1 DMPK coiled coil domain like PRKG1_interact PF15898.5 EMC84717.1 - 0.0061 17.4 10.5 0.0061 17.4 10.5 3.6 1 1 2 3 3 3 2 cGMP-dependent protein kinase interacting domain TPR_MLP1_2 PF07926.12 EMC84717.1 - 0.011 15.8 35.9 0.043 13.9 10.0 3.2 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein YabA PF06156.13 EMC84717.1 - 0.18 12.4 26.0 2.8 8.6 5.5 3.5 1 1 2 3 3 3 0 Initiation control protein YabA ATG16 PF08614.11 EMC84717.1 - 0.75 10.0 40.1 1.2 9.3 22.4 2.5 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Pepsin-I3 PF06394.13 EMC84717.1 - 1.1 9.5 7.6 0.58 10.4 4.2 2.4 2 1 0 2 2 2 0 Pepsin inhibitor-3-like repeated domain FPP PF05911.11 EMC84717.1 - 4.4 5.4 32.2 2 6.5 18.6 2.1 1 1 2 3 3 3 0 Filament-like plant protein, long coiled-coil ADIP PF11559.8 EMC84717.1 - 5.2 7.2 33.4 1 9.4 9.5 3.2 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Titin_Ig-rpts PF06582.12 EMC84717.1 - 5.7 7.0 9.5 0.6 10.1 0.9 3.4 3 0 0 3 3 3 0 Titin repeat DUF1664 PF07889.12 EMC84717.1 - 6.7 6.8 12.5 1.6 8.7 5.1 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Fez1 PF06818.15 EMC84717.1 - 8.5 6.8 32.7 0.23 11.9 13.8 2.4 1 1 1 2 2 2 0 Fez1 DUF2514 PF10721.9 EMC84717.1 - 9 6.3 12.5 0.39 10.7 4.3 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF2514) FOP_dimer PF09398.10 EMC84718.1 - 1.5e-21 76.4 0.1 2.7e-21 75.6 0.1 1.4 1 0 0 1 1 1 1 FOP N terminal dimerisation domain LisH_2 PF16045.5 EMC84718.1 - 2.9e-05 23.0 0.1 5.5e-05 22.1 0.0 1.5 1 1 0 1 1 1 1 LisH LisH PF08513.11 EMC84718.1 - 0.36 10.9 2.1 0.6 10.2 1.1 1.8 2 0 0 2 2 2 0 LisH ABC_membrane PF00664.23 EMC84719.1 - 6.4e-92 308.1 38.4 2.4e-51 175.0 5.3 2.7 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 EMC84719.1 - 1.9e-54 183.9 0.0 9e-29 100.7 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EMC84719.1 - 1.2e-09 37.9 1.4 0.00065 19.2 0.0 3.9 2 2 2 4 4 4 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EMC84719.1 - 5.7e-06 26.4 0.5 0.059 13.5 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC84719.1 - 5.9e-06 26.3 0.2 0.0022 17.9 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EMC84719.1 - 8.9e-06 26.2 0.1 0.0022 18.4 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 EMC84719.1 - 0.00016 21.3 0.3 0.011 15.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 EMC84719.1 - 0.0012 18.7 1.4 3.1 7.5 0.0 3.6 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system ABC_ATPase PF09818.9 EMC84719.1 - 0.0016 17.4 0.0 0.15 10.9 0.0 3.0 3 0 0 3 3 3 1 Predicted ATPase of the ABC class Zeta_toxin PF06414.12 EMC84719.1 - 0.0022 17.3 1.9 0.0064 15.8 0.1 2.2 2 0 0 2 2 2 1 Zeta toxin Dynamin_N PF00350.23 EMC84719.1 - 0.0022 18.1 2.0 0.03 14.4 0.3 2.7 2 0 0 2 2 2 1 Dynamin family AAA_22 PF13401.6 EMC84719.1 - 0.0089 16.3 2.4 1.8 8.8 0.0 3.4 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EMC84719.1 - 0.016 14.7 0.3 0.58 9.6 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_29 PF13555.6 EMC84719.1 - 0.018 14.8 2.6 2.4 8.0 0.1 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain Roc PF08477.13 EMC84719.1 - 0.039 14.2 0.8 20 5.5 0.0 3.4 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 EMC84719.1 - 0.041 13.1 0.6 11 5.1 0.1 2.7 2 1 0 2 2 2 0 NB-ARC domain DUF815 PF05673.13 EMC84719.1 - 0.15 11.1 0.4 4 6.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) DUF87 PF01935.17 EMC84719.1 - 0.24 11.5 3.2 4.3 7.4 0.4 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_23 PF13476.6 EMC84719.1 - 0.5 10.8 7.4 4.1 7.9 0.0 3.3 4 0 0 4 4 3 0 AAA domain CarboxypepD_reg PF13620.6 EMC84720.1 - 1.8e-46 156.3 2.2 2.5e-08 34.1 0.2 9.6 9 1 0 9 9 9 7 Carboxypeptidase regulatory-like domain SdrD_B PF17210.3 EMC84720.1 - 2.3e-27 95.4 0.8 0.00071 19.8 0.0 9.3 9 0 0 9 9 9 5 SdrD B-like domain DUF2012 PF09430.10 EMC84720.1 - 5.5e-22 78.2 0.1 2.7e-07 30.7 0.0 7.6 7 1 1 8 8 8 4 Protein of unknown function (DUF2012) CarbopepD_reg_2 PF13715.6 EMC84720.1 - 4.2e-19 68.3 3.9 2e-05 24.5 0.4 8.4 8 0 0 8 8 8 5 CarboxypepD_reg-like domain SpaA PF17802.1 EMC84720.1 - 1e-15 57.8 1.6 0.0015 18.8 0.0 7.0 8 0 0 8 8 8 3 Prealbumin-like fold domain fn3_3 PF14686.6 EMC84720.1 - 2e-12 46.7 0.0 0.0028 17.4 0.0 7.0 7 0 0 7 7 7 2 Polysaccharide lyase family 4, domain II Y_Y_Y PF07495.13 EMC84720.1 - 2.9e-06 27.2 0.8 1.3 9.1 0.0 5.3 5 0 0 5 5 5 1 Y_Y_Y domain DUF1416 PF07210.12 EMC84720.1 - 4.1e-06 26.6 0.3 4 7.4 0.0 5.8 6 1 1 7 7 7 2 Protein of unknown function (DUF1416) DUF2846 PF11008.8 EMC84720.1 - 1.5e-05 24.9 0.3 13 5.9 0.0 5.2 5 0 0 5 5 5 0 Protein of unknown function (DUF2846) DUF3823 PF12866.7 EMC84720.1 - 7.8e-05 22.9 0.1 0.094 13.0 0.0 4.4 4 0 0 4 4 4 1 Protein of unknown function (DUF3823) N-terminal domain Dioxygenase_C PF00775.21 EMC84720.1 - 0.0001 21.8 0.0 15 5.0 0.0 5.5 4 1 1 5 5 5 0 Dioxygenase TTR-52 PF01060.23 EMC84720.1 - 0.002 18.8 0.0 18 6.1 0.0 4.9 5 0 0 5 5 5 0 Transthyretin-like family DUF2141 PF09912.9 EMC84720.1 - 0.095 12.6 0.0 14 5.7 0.0 4.0 5 0 0 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2141) Cupredoxin_1 PF13473.6 EMC84720.1 - 0.1 12.7 0.0 4.4 7.5 0.0 3.6 2 1 1 3 3 3 0 Cupredoxin-like domain Ribosomal_S8 PF00410.19 EMC84721.1 - 1.8e-22 79.6 0.0 2.6e-22 79.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 Reticulon PF02453.17 EMC84722.1 - 0.0011 18.9 3.8 0.0015 18.5 3.8 1.1 1 0 0 1 1 1 1 Reticulon BCL_N PF04714.13 EMC84722.1 - 0.85 9.7 0.1 0.85 9.7 0.1 2.5 3 0 0 3 3 3 0 BCL7, N-terminal conserver region SMG1 PF15785.5 EMC84723.1 - 3e-254 845.1 13.6 3.5e-254 844.9 10.1 2.4 2 0 0 2 2 2 1 Serine/threonine-protein kinase smg-1 PI3_PI4_kinase PF00454.27 EMC84723.1 - 1e-52 179.4 0.0 2.8e-52 178.0 0.0 1.8 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase SMG1_N PF17229.2 EMC84723.1 - 5.2e-49 165.4 4.5 1.1e-48 164.4 4.5 1.6 1 0 0 1 1 1 1 Serine/threonine-protein kinase SMG1 N-terminal FATC PF02260.20 EMC84723.1 - 5.2e-12 45.4 0.1 2.6e-11 43.1 0.1 2.4 1 0 0 1 1 1 1 FATC domain HEAT PF02985.22 EMC84723.1 - 0.035 14.4 0.4 0.78 10.2 0.0 3.5 2 0 0 2 2 2 0 HEAT repeat XhlA PF10779.9 EMC84723.1 - 1.1 9.5 3.3 6.9 7.0 0.6 3.3 2 0 0 2 2 2 0 Haemolysin XhlA FRB_dom PF08771.11 EMC84723.1 - 1.2 9.6 12.3 3.8 8.0 1.5 5.2 3 1 0 3 3 3 0 FKBP12-rapamycin binding domain Lectin_C PF00059.21 EMC84724.1 - 3.3e-18 66.4 0.1 4.1e-18 66.1 0.1 1.1 1 0 0 1 1 1 1 Lectin C-type domain C2 PF00168.30 EMC84725.1 - 1e-42 144.6 0.1 1.4e-21 76.7 0.0 2.2 2 0 0 2 2 2 2 C2 domain COQ7 PF03232.13 EMC84727.1 - 7.7e-75 250.4 0.0 8.7e-75 250.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.17 EMC84727.1 - 0.0095 16.3 0.0 0.13 12.7 0.0 2.1 1 1 1 2 2 2 1 Rubrerythrin Muraidase PF11860.8 EMC84727.1 - 0.067 13.4 0.0 2.1 8.5 0.0 2.2 2 0 0 2 2 2 0 N-acetylmuramidase Clathrin-link PF09268.10 EMC84728.1 - 0.015 14.6 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 Clathrin, heavy-chain linker TMC PF07810.13 EMC84729.1 - 6.1e-40 136.3 4.2 1.4e-39 135.1 0.5 3.3 2 1 0 2 2 2 1 TMC domain LrgA PF03788.14 EMC84729.1 - 0.22 11.5 6.6 0.95 9.5 0.7 3.6 3 0 0 3 3 3 0 LrgA family CALM_bind PF16025.5 EMC84730.1 - 9.5e-18 64.4 0.7 9.5e-18 64.4 0.7 4.2 4 1 1 5 5 5 2 Calcium-dependent calmodulin binding Rx_N PF18052.1 EMC84730.1 - 3.4 8.0 8.6 0.86 9.9 0.4 2.9 2 0 0 2 2 2 0 Rx N-terminal domain SMAP PF15477.6 EMC84731.1 - 2.6e-15 57.1 0.6 4.4e-15 56.4 0.6 1.4 1 0 0 1 1 1 1 Small acidic protein family 7tm_4 PF13853.6 EMC84732.1 - 1e-48 166.5 14.0 1.2e-48 166.3 14.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC84732.1 - 3.3e-29 102.0 12.1 4.4e-29 101.6 12.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V-set PF07686.17 EMC84733.1 - 1.6e-13 50.8 0.0 2e-13 50.5 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.16 EMC84733.1 - 4.6e-08 33.0 0.0 8.1e-08 32.2 0.0 1.4 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC84733.1 - 5.3e-08 33.4 0.0 7e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC84733.1 - 6.9e-05 23.0 0.0 0.00013 22.1 0.0 1.4 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC84733.1 - 0.006 16.9 0.0 0.025 14.9 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC84734.1 - 3.8e-10 39.9 0.0 4.6e-10 39.7 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC84734.1 - 1.6e-05 25.4 0.0 3.1e-05 24.5 0.0 1.4 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC84734.1 - 0.0015 18.9 0.0 0.0075 16.6 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC84734.1 - 0.0015 18.5 0.0 0.0024 17.9 0.0 1.3 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC84734.1 - 0.11 12.7 0.0 0.25 11.6 0.0 1.6 1 1 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 EMC84736.1 - 9.5e-12 45.1 0.1 1.2e-11 44.8 0.1 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC84736.1 - 9e-07 29.4 0.0 1.3e-06 28.9 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC84736.1 - 6.9e-06 26.0 0.0 2.6e-05 24.2 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC84736.1 - 0.0029 17.8 0.0 0.0052 16.9 0.0 1.4 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC84736.1 - 0.065 13.6 0.0 0.23 11.8 0.0 1.8 1 1 0 1 1 1 0 Immunoglobulin domain AraC_binding_2 PF14525.6 EMC84736.1 - 0.088 12.5 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 AraC-binding-like domain DNA_ligase_ZBD PF03119.16 EMC84736.1 - 0.11 12.6 0.0 3.9 7.6 0.0 2.2 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain V-set PF07686.17 EMC84737.1 - 1.3e-09 38.2 0.0 1.5e-09 37.9 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC84737.1 - 1.3e-05 25.7 0.0 2.7e-05 24.7 0.0 1.4 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC84737.1 - 0.0025 18.1 0.0 0.013 15.9 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC84737.1 - 0.0081 16.2 0.0 0.013 15.6 0.0 1.3 1 1 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 EMC84738.1 - 1.1e-12 48.1 0.0 1.3e-12 47.8 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC84738.1 - 0.00045 20.8 0.0 0.00085 19.9 0.0 1.4 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC84738.1 - 0.0015 18.7 0.1 0.0039 17.3 0.1 1.6 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC84738.1 - 0.0022 18.0 0.0 0.0046 17.0 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 EMC84739.1 - 7.3e-10 39.0 0.0 8.4e-10 38.8 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC84739.1 - 0.0079 16.8 0.0 0.026 15.1 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain Keratin PF02422.16 EMC84740.1 - 6.2e-42 141.2 12.4 6.6e-42 141.1 12.4 1.0 1 0 0 1 1 1 1 Keratin V-set PF07686.17 EMC84741.1 - 1.5e-14 54.1 0.2 1.7e-14 53.9 0.2 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC84741.1 - 1.5e-05 25.5 0.1 3e-05 24.5 0.1 1.5 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC84741.1 - 3.8e-05 23.7 0.0 5.6e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC84741.1 - 0.0041 17.3 0.2 0.0072 16.5 0.2 1.4 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC84742.1 - 9.2e-07 29.0 0.0 1.1e-06 28.8 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC84742.1 - 0.068 13.8 0.0 0.13 12.8 0.0 1.4 1 1 0 1 1 1 0 Immunoglobulin domain Keratin PF02422.16 EMC84743.1 - 4.8e-28 96.7 3.4 5.2e-28 96.6 3.4 1.0 1 0 0 1 1 1 1 Keratin V-set PF07686.17 EMC84744.1 - 2.7e-07 30.7 0.0 3.1e-07 30.5 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC84744.1 - 0.013 16.0 0.0 0.022 15.4 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin domain Keratin PF02422.16 EMC84745.1 - 2e-36 123.5 21.7 2.5e-36 123.2 21.7 1.1 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC84746.1 - 8e-41 137.7 10.6 8.6e-41 137.6 10.6 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC84747.1 - 5.1e-25 87.0 6.4 5.4e-25 86.9 6.4 1.0 1 0 0 1 1 1 1 Keratin V-set PF07686.17 EMC84748.1 - 1.2e-09 38.3 0.0 1.3e-09 38.1 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC84748.1 - 0.0022 18.6 0.0 0.0046 17.5 0.0 1.4 1 1 0 1 1 1 1 Immunoglobulin domain Keratin PF02422.16 EMC84749.1 - 5.3e-37 125.4 10.0 5.5e-37 125.3 10.0 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC84750.1 - 3.1e-37 126.1 20.3 3.8e-37 125.9 20.3 1.1 1 0 0 1 1 1 1 Keratin V-set PF07686.17 EMC84751.1 - 2.4e-08 34.1 0.0 2.8e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC84751.1 - 0.027 15.1 0.0 0.056 14.0 0.0 1.5 1 1 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 EMC84752.1 - 2.6e-09 37.2 1.0 3.1e-09 37.0 1.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC84752.1 - 0.0022 18.6 0.3 0.0031 18.1 0.3 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC84752.1 - 0.0055 16.7 0.2 0.0085 16.1 0.2 1.3 1 1 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 EMC84753.1 - 1.3e-09 38.2 0.0 1.5e-09 38.0 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.16 EMC84755.1 - 6.2e-06 26.2 0.0 6.4e-06 26.1 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 EMC84755.1 - 4.4e-05 23.6 0.0 4.6e-05 23.5 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC84755.1 - 0.00028 21.4 0.0 0.00032 21.3 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain V-set_CD47 PF08204.11 EMC84755.1 - 0.0019 18.2 0.0 0.002 18.1 0.0 1.0 1 0 0 1 1 1 1 CD47 immunoglobulin-like domain ig PF00047.25 EMC84755.1 - 0.0089 16.2 0.0 0.0091 16.2 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC84755.1 - 0.037 14.4 0.0 0.037 14.4 0.0 1.1 1 0 0 1 1 1 0 Immunoglobulin domain Herpes_gE PF02480.16 EMC84755.1 - 0.042 12.6 0.0 0.042 12.6 0.0 1.0 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E zf-C2H2_6 PF13912.6 EMC84757.1 - 0.0012 18.8 2.4 0.5 10.4 0.0 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC84757.1 - 0.15 12.5 0.1 0.15 12.5 0.1 4.6 6 0 0 6 6 6 0 Zinc finger, C2H2 type Glutenin_hmw PF03157.13 EMC84757.1 - 0.51 8.7 305.3 0.12 10.8 48.7 7.7 1 1 8 9 9 9 0 High molecular weight glutenin subunit 7tm_4 PF13853.6 EMC84758.1 - 4.1e-08 33.3 0.9 4.6e-08 33.1 0.9 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC84758.1 - 4.3e-07 29.5 0.1 5.4e-07 29.2 0.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CUB PF00431.20 EMC84759.1 - 1.1e-17 64.4 0.0 1.8e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 CUB domain PDGF PF00341.17 EMC84759.1 - 3.1e-13 49.8 12.0 4.8e-13 49.2 12.0 1.3 1 0 0 1 1 1 1 PDGF/VEGF domain Neur_chan_LBD PF02931.23 EMC84760.1 - 5.3e-53 179.7 0.2 7e-53 179.3 0.2 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC84760.1 - 3.4e-35 122.2 0.1 1.2e-34 120.4 0.1 2.0 2 1 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region DUF3267 PF11667.8 EMC84760.1 - 0.011 16.1 1.8 0.14 12.5 1.8 2.4 1 1 0 1 1 1 0 Putative zincin peptidase Lig_chan PF00060.26 EMC84761.1 - 6.1e-60 201.4 0.1 1e-59 200.6 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel ANF_receptor PF01094.28 EMC84761.1 - 1.4e-58 198.7 0.1 2.4e-58 198.0 0.1 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan-Glu_bd PF10613.9 EMC84761.1 - 6.5e-46 155.3 0.1 1.3e-45 154.3 0.1 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 EMC84761.1 - 2e-24 86.3 0.0 3.9e-24 85.3 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.6 EMC84761.1 - 1.5e-05 24.8 0.0 3.7e-05 23.5 0.0 1.6 1 1 0 1 1 1 1 Periplasmic binding protein FAM198 PF15051.6 EMC84762.1 - 1.5e-146 487.4 1.0 1.8e-146 487.1 1.0 1.1 1 0 0 1 1 1 1 FAM198 protein TMEM144 PF07857.12 EMC84763.1 - 2.2e-131 437.8 16.0 2.5e-131 437.7 16.0 1.0 1 0 0 1 1 1 1 Transmembrane family, TMEM144 of transporters Sugar_transport PF06800.12 EMC84763.1 - 4.9e-12 45.8 11.7 1e-10 41.4 3.1 2.4 2 0 0 2 2 2 2 Sugar transport protein Erg28 PF03694.13 EMC84763.1 - 0.023 15.1 0.8 0.53 10.7 0.4 2.4 2 0 0 2 2 2 0 Erg28 like protein Hormone_4 PF00220.17 EMC84763.1 - 2.9 8.1 4.9 0.72 10.0 0.6 2.3 2 0 0 2 2 2 0 Neurohypophysial hormones, N-terminal Domain LRR_8 PF13855.6 EMC84764.1 - 4.5e-69 228.1 60.6 1.8e-18 66.0 2.0 5.9 1 1 6 7 7 7 7 Leucine rich repeat 7tm_1 PF00001.21 EMC84764.1 - 1.6e-26 93.2 16.8 2.4e-26 92.7 16.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_5 PF13306.6 EMC84764.1 - 1.5e-18 67.0 7.2 1.7e-08 34.5 1.9 2.6 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 EMC84764.1 - 9.2e-18 64.1 31.1 3e-07 30.7 2.1 6.6 2 1 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC84764.1 - 2.2e-10 40.3 18.7 0.0019 17.7 0.5 4.1 1 1 3 4 4 4 4 Leucine-rich repeat Ldl_recept_a PF00057.18 EMC84764.1 - 1.3e-06 28.5 5.8 1.3e-06 28.5 5.8 2.4 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A LRRNT PF01462.18 EMC84764.1 - 8.4e-05 22.1 0.5 0.00028 20.5 0.1 2.1 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 EMC84764.1 - 0.0093 16.4 25.3 3.5 8.6 0.1 9.2 8 2 1 9 9 9 1 Leucine Rich Repeat LRR_6 PF13516.6 EMC84764.1 - 0.22 11.7 13.2 24 5.3 0.2 6.3 6 0 0 6 6 6 0 Leucine Rich repeat ETF_QO PF05187.13 EMC84765.1 - 7.1e-49 164.3 0.0 1.3e-48 163.5 0.0 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S FAD_binding_2 PF00890.24 EMC84765.1 - 4.1e-09 36.0 0.8 1.6e-05 24.2 1.1 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EMC84765.1 - 6.5e-09 35.8 1.5 2.5e-05 24.0 0.4 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.17 EMC84765.1 - 9.4e-08 31.6 0.0 1.3e-05 24.6 0.0 2.1 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 EMC84765.1 - 1.1e-06 28.8 0.1 7.4e-06 26.1 0.1 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMC84765.1 - 1.5e-06 27.7 0.1 2e-06 27.3 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMC84765.1 - 5.5e-05 22.4 0.1 7.7e-05 21.9 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 EMC84765.1 - 7.3e-05 22.2 0.1 0.00013 21.3 0.1 1.5 1 1 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EMC84765.1 - 0.00014 20.7 0.5 0.00021 20.1 0.5 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 EMC84765.1 - 0.0002 21.9 0.1 0.3 11.7 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EMC84765.1 - 0.00034 20.6 0.0 0.00087 19.3 0.1 1.6 2 0 0 2 2 1 1 FAD-NAD(P)-binding FAD_oxidored PF12831.7 EMC84765.1 - 0.0024 17.3 0.1 0.0037 16.7 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EMC84765.1 - 0.0061 15.5 0.1 0.046 12.6 0.1 2.1 2 0 0 2 2 2 1 Tryptophan halogenase Pyr_redox_3 PF13738.6 EMC84765.1 - 0.0073 15.6 0.1 0.012 14.9 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EMC84765.1 - 0.016 14.3 0.2 0.025 13.7 0.2 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EMC84765.1 - 0.037 13.3 0.0 0.06 12.6 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.6 EMC84765.1 - 0.043 13.0 0.0 0.064 12.4 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Fer4_7 PF12838.7 EMC84765.1 - 0.11 13.1 0.5 0.29 11.8 0.5 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain Pro_isomerase PF00160.21 EMC84766.1 - 7.2e-49 166.1 0.2 1.1e-48 165.4 0.2 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.28 EMC84766.1 - 7.7e-12 44.5 1.6 0.00011 21.8 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMC84766.1 - 2.2e-11 43.0 1.4 0.022 14.9 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EMC84766.1 - 1.8e-05 24.4 3.4 0.026 14.2 0.0 3.4 3 0 0 3 3 3 1 TPR repeat TPR_12 PF13424.6 EMC84766.1 - 0.00037 20.7 2.0 0.19 12.0 0.6 3.2 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EMC84766.1 - 0.0005 19.9 0.1 1.4 9.1 0.1 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMC84766.1 - 0.0014 19.3 0.8 0.49 11.3 0.0 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 EMC84766.1 - 0.0082 16.3 1.1 0.021 14.9 0.1 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMC84766.1 - 0.018 15.1 1.8 1.2 9.3 0.0 3.0 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.6 EMC84766.1 - 0.023 15.2 2.9 0.081 13.4 0.9 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat FNIP_M PF14637.6 EMC84767.1 - 5.8e-91 304.5 1.0 9.4e-91 303.8 1.0 1.3 1 0 0 1 1 1 1 Folliculin-interacting protein middle domain FNIP_C PF14638.6 EMC84767.1 - 9.9e-72 240.6 0.8 2.6e-71 239.2 0.8 1.7 1 0 0 1 1 1 1 Folliculin-interacting protein C-terminus FNIP_N PF14636.6 EMC84767.1 - 2.8e-25 90.1 0.7 2.8e-25 90.1 0.7 4.1 3 1 0 3 3 3 1 Folliculin-interacting protein N-terminus DUF4562 PF15123.6 EMC84768.1 - 5.4e-46 155.3 0.1 6.3e-46 155.0 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4562) RasGEF PF00617.19 EMC84770.1 - 2.6e-52 177.6 1.2 4.9e-52 176.7 1.2 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EMC84770.1 - 1.1e-12 48.1 0.2 2.1e-11 44.0 0.2 2.7 1 1 0 1 1 1 1 RasGEF N-terminal motif RA PF00788.23 EMC84770.1 - 1.8e-11 44.5 0.1 5.4e-11 43.0 0.1 1.9 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PDZ PF00595.24 EMC84770.1 - 2.4e-10 40.6 0.0 5.9e-10 39.4 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC84770.1 - 1e-09 38.1 0.0 2.6e-09 36.8 0.0 1.7 1 0 0 1 1 1 1 PDZ domain cNMP_binding PF00027.29 EMC84770.1 - 0.00015 21.8 0.0 0.00034 20.6 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain PDZ_2 PF13180.6 EMC84770.1 - 0.00021 21.6 0.0 0.00059 20.1 0.0 1.7 1 0 0 1 1 1 1 PDZ domain Cullin PF00888.22 EMC84773.1 - 0.00011 20.9 0.0 0.00023 19.9 0.0 1.4 1 1 0 1 1 1 1 Cullin family ANAPC10 PF03256.16 EMC84773.1 - 0.014 15.0 0.0 0.027 14.1 0.0 1.4 1 1 0 1 1 1 0 Anaphase-promoting complex, subunit 10 (APC10) Prolamin_like PF05617.11 EMC84774.1 - 0.00016 21.8 7.0 1.1 9.5 0.1 5.0 1 1 2 4 4 4 3 Prolamin-like GDNF PF02351.16 EMC84774.1 - 0.41 11.6 10.2 1 10.4 0.7 2.8 1 1 1 2 2 2 0 GDNF/GAS1 domain RecA_dep_nuc PF16786.5 EMC84774.1 - 0.59 10.3 23.1 9.4 6.4 3.4 4.7 1 1 4 5 5 5 0 Recombination enhancement, RecA-dependent nuclease I-EGF_1 PF18372.1 EMC84774.1 - 0.96 9.6 31.2 5.2 7.3 0.1 9.0 6 3 6 12 12 12 0 Integrin beta epidermal growth factor like domain 1 FGGY_N PF00370.21 EMC84775.1 - 2.4e-76 256.5 0.0 3.6e-76 256.0 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 EMC84775.1 - 6.2e-66 221.9 0.5 1.3e-65 220.9 0.5 1.5 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain DUF4569 PF15133.6 EMC84776.1 - 6.3e-101 338.1 4.9 7.1e-101 337.9 4.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4569) UPF0731 PF14982.6 EMC84777.1 - 0.006 16.7 0.1 0.18 12.0 0.1 2.2 2 0 0 2 2 2 2 UPF0731 family CUE PF02845.16 EMC84778.1 - 9.2e-10 38.0 0.2 2.7e-09 36.5 0.2 1.8 2 0 0 2 2 2 1 CUE domain PRESAN PF09687.10 EMC84779.1 - 0.011 16.3 3.8 0.011 16.3 3.8 1.8 2 1 0 2 2 2 0 Plasmodium RESA N-terminal TssC PF17541.2 EMC84779.1 - 0.052 12.4 2.1 0.058 12.2 2.1 1.0 1 0 0 1 1 1 0 Type VI secretion system, TssC, VipB LRS4 PF10422.9 EMC84779.1 - 0.079 12.5 2.3 0.096 12.2 2.3 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 Spectrin PF00435.21 EMC84780.1 - 8.8e-130 424.7 198.7 8.4e-19 68.0 3.9 17.2 15 1 1 17 17 17 15 Spectrin repeat CH PF00307.31 EMC84780.1 - 8.4e-41 138.6 3.8 6.2e-21 74.6 0.0 5.5 4 0 0 4 4 4 3 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EMC84780.1 - 1.5e-07 31.1 0.0 0.00062 19.6 0.0 3.8 3 0 0 3 3 3 2 CAMSAP CH domain EZH2_WD-Binding PF11616.8 EMC84780.1 - 0.01 15.9 2.5 0.085 13.0 0.2 3.2 2 0 0 2 2 2 0 WD repeat binding protein EZH2 DUF3800 PF12686.7 EMC84780.1 - 0.13 12.9 3.1 1.2e+02 3.3 0.6 6.2 2 2 0 2 2 2 0 Protein of unknown function (DUF3800) PMP22_Claudin PF00822.20 EMC84781.1 - 5.3e-06 26.4 5.8 6.7e-06 26.1 5.8 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_3 PF06653.11 EMC84781.1 - 0.0031 17.5 9.0 0.0067 16.4 9.0 1.5 1 1 0 1 1 1 1 Tight junction protein, Claudin-like Clc-like PF07062.12 EMC84781.1 - 0.0073 15.8 10.4 0.031 13.8 0.5 2.1 1 1 1 2 2 2 2 Clc-like ApoO PF09769.9 EMC84781.1 - 0.15 12.0 0.1 0.22 11.5 0.1 1.3 1 0 0 1 1 1 0 Apolipoprotein O Claudin_2 PF13903.6 EMC84781.1 - 0.85 9.3 16.1 0.048 13.4 10.2 1.8 1 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Yip1 PF04893.17 EMC84781.1 - 0.9 9.2 14.3 1.8 8.3 14.3 1.5 1 1 0 1 1 1 0 Yip1 domain DUF2721 PF11026.8 EMC84781.1 - 9.9 6.1 10.6 0.85 9.5 4.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Gag_p30 PF02093.16 EMC84783.1 - 1.2e-19 70.7 0.1 1.4e-19 70.5 0.1 1.0 1 0 0 1 1 1 1 Gag P30 core shell protein Interferon PF00143.19 EMC84784.1 - 1.9e-47 161.4 8.4 2.2e-47 161.2 8.4 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain PTPLA PF04387.14 EMC84785.1 - 6.6e-39 133.3 7.0 1e-38 132.6 7.0 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Focadhesin PF11229.8 EMC84786.1 - 2.9e-296 983.5 10.9 5e-296 982.7 10.9 1.4 1 0 0 1 1 1 1 Focadhesin DUF3730 PF12530.8 EMC84786.1 - 1.5e-71 240.7 1.0 1.5e-71 240.7 1.0 3.7 4 0 0 4 4 4 1 Protein of unknown function (DUF3730) AHD PF17793.1 EMC84787.1 - 2e-27 94.8 1.4 3.8e-27 93.9 1.4 1.5 1 0 0 1 1 1 1 ANC1 homology domain (AHD) YEATS PF03366.16 EMC84787.1 - 3.6e-08 33.2 0.0 7.1e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 YEATS family BET PF17035.5 EMC84787.1 - 0.042 14.0 0.2 0.11 12.7 0.2 1.7 1 0 0 1 1 1 0 Bromodomain extra-terminal - transcription regulation PBP1_TM PF14812.6 EMC84787.1 - 0.18 12.2 0.2 0.18 12.2 0.2 3.7 4 0 0 4 4 4 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Na_Ca_ex PF01699.24 EMC84788.1 - 3.7e-59 199.0 52.9 7.9e-31 107.1 22.5 2.7 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Ceramidase PF05875.12 EMC84789.1 - 1.5e-40 139.3 12.0 1.6e-40 139.2 12.0 1.0 1 0 0 1 1 1 1 Ceramidase Ribosomal_S6e PF01092.19 EMC84790.1 - 4.2e-64 214.2 1.5 9.5e-64 213.0 0.0 2.1 2 0 0 2 2 2 1 Ribosomal protein S6e DUF4574 PF15141.6 EMC84790.1 - 1.2 9.0 5.8 2.3 8.2 5.8 1.4 1 0 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 DENN PF02141.21 EMC84791.1 - 3.4e-62 209.7 3.7 6.8e-62 208.7 3.7 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 EMC84791.1 - 9.3e-15 55.1 0.4 3.6e-14 53.2 0.4 2.1 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 EMC84791.1 - 8.4e-13 48.1 2.5 8.4e-13 48.1 2.5 2.2 2 0 0 2 2 2 1 dDENN domain PPR_2 PF13041.6 EMC84791.1 - 2.1e-05 24.6 0.0 0.00089 19.4 0.0 2.5 2 0 0 2 2 2 1 PPR repeat family PPR_3 PF13812.6 EMC84791.1 - 0.014 15.5 0.2 0.14 12.3 0.0 2.3 2 0 0 2 2 2 0 Pentatricopeptide repeat domain PPR PF01535.20 EMC84791.1 - 0.12 12.7 0.0 0.35 11.2 0.0 1.9 1 0 0 1 1 1 0 PPR repeat zf-C3HC4_2 PF13923.6 EMC84792.1 - 3.1e-13 49.3 9.4 6.5e-13 48.3 9.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC84792.1 - 3.1e-10 39.8 8.4 5.3e-10 39.0 8.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMC84792.1 - 8.3e-09 35.2 5.8 1.4e-08 34.5 5.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC84792.1 - 9.5e-09 35.5 10.4 1.8e-08 34.6 10.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EMC84792.1 - 5.1e-06 26.7 8.1 1e-05 25.7 8.1 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EMC84792.1 - 6.6e-06 26.0 6.5 1.1e-05 25.2 6.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EMC84792.1 - 1.1e-05 25.4 7.1 2.9e-05 24.0 7.1 1.8 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EMC84792.1 - 0.00011 21.9 7.9 0.0005 19.9 8.0 2.0 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EMC84792.1 - 0.0052 16.8 2.9 0.0099 15.9 2.9 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-FPG_IleRS PF06827.14 EMC84792.1 - 0.045 13.6 0.5 7.5 6.5 0.0 2.7 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS Baculo_IE-1 PF05290.11 EMC84792.1 - 0.21 11.6 4.1 0.33 10.9 4.1 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-C3HC4_4 PF15227.6 EMC84792.1 - 0.27 11.4 11.7 0.51 10.5 11.7 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 EMC84792.1 - 1 9.2 3.5 2.2 8.1 3.5 1.6 1 0 0 1 1 1 0 RING-like zinc finger Perilipin PF03036.16 EMC84793.1 - 1.3e-169 564.3 15.0 1.6e-169 564.1 15.0 1.0 1 0 0 1 1 1 1 Perilipin family Syntaxin-6_N PF09177.11 EMC84793.1 - 0.01 16.4 8.3 0.39 11.3 0.8 3.2 2 1 1 3 3 3 2 Syntaxin 6, N-terminal HBM PF16591.5 EMC84793.1 - 0.011 15.2 1.8 0.011 15.2 1.8 2.2 3 0 0 3 3 3 0 Helical bimodular sensor domain IL11 PF07400.11 EMC84793.1 - 0.03 14.0 1.1 0.17 11.5 0.1 2.4 1 1 1 2 2 2 0 Interleukin 11 Snapin_Pallidin PF14712.6 EMC84793.1 - 0.46 10.9 5.7 2.7 8.5 2.9 2.7 2 0 0 2 2 2 0 Snapin/Pallidin SH3BP5 PF05276.14 EMC84793.1 - 0.99 9.2 9.2 0.58 9.9 4.6 2.5 1 1 1 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) V-SNARE_C PF12352.8 EMC84793.1 - 3.3 8.1 6.8 3.7 7.9 2.0 2.5 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus FliJ PF02050.16 EMC84793.1 - 8.7 6.6 11.1 19 5.5 6.9 2.9 2 2 0 2 2 2 0 Flagellar FliJ protein HAUS6_N PF14661.6 EMC84795.1 - 7.2e-46 156.6 0.4 1.8e-45 155.3 0.4 1.7 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 6 N-terminus NSP10 PF09401.10 EMC84796.1 - 0.12 12.4 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 RNA synthesis protein NSP10 I-set PF07679.16 EMC84797.1 - 5.3e-40 135.4 0.0 3.2e-12 46.4 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC84797.1 - 4.2e-36 123.4 0.0 6.4e-12 45.9 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 EMC84797.1 - 5.3e-26 90.8 0.0 1.6e-08 34.7 0.0 3.9 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 EMC84797.1 - 3.6e-19 68.7 0.0 1e-06 28.8 0.0 4.0 3 1 0 3 3 3 3 Immunoglobulin domain PLAC PF08686.11 EMC84797.1 - 2.8e-08 34.4 10.4 9.9e-08 32.6 10.4 2.1 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain C2-set_2 PF08205.12 EMC84797.1 - 2.6e-06 27.4 0.8 0.39 10.8 0.0 4.5 3 2 1 4 4 4 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 EMC84797.1 - 1.3e-05 25.3 0.1 0.0066 16.6 0.0 3.9 3 3 2 5 5 5 1 Immunoglobulin V-set domain TSP_1 PF00090.19 EMC84797.1 - 3.6e-05 23.9 11.5 3.6e-05 23.9 11.5 5.7 4 1 1 5 5 5 3 Thrombospondin type 1 domain Ig_C17orf99 PF17736.1 EMC84797.1 - 0.0072 16.3 0.1 5.6 7.1 0.0 3.3 3 0 0 3 3 3 1 C17orf99 Ig domain TSP_1 PF00090.19 EMC84798.1 - 4.4e-22 78.0 73.9 1.2e-05 25.4 3.9 7.9 7 2 0 7 7 7 6 Thrombospondin type 1 domain ADAM_spacer1 PF05986.14 EMC84798.1 - 0.0019 18.2 0.0 0.0029 17.6 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Sad1_UNC PF07738.13 EMC84800.1 - 2.3e-34 118.3 0.0 2.5e-34 118.1 0.0 1.0 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal zf-HC5HC2H PF13771.6 EMC84801.1 - 7e-09 35.8 5.9 2.1e-08 34.3 5.9 1.9 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EMC84801.1 - 3.7e-08 33.5 1.4 1.1e-07 32.0 1.4 1.7 1 0 0 1 1 1 1 PHD-zinc-finger like domain SH2 PF00017.24 EMC84803.1 - 3e-06 27.2 0.0 3.7e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 SH2 domain Abhydrolase_1 PF00561.20 EMC84804.1 - 8.8e-22 78.0 0.3 4.3e-21 75.7 0.3 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMC84804.1 - 6.3e-18 66.2 0.3 8.4e-18 65.8 0.3 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMC84804.1 - 4.7e-13 48.9 0.2 2e-12 46.9 0.2 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Lipase_3 PF01764.25 EMC84804.1 - 0.01 15.7 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Thioesterase PF00975.20 EMC84804.1 - 0.022 14.9 1.4 0.12 12.5 0.1 2.3 2 1 0 2 2 2 0 Thioesterase domain PGAP1 PF07819.13 EMC84804.1 - 0.053 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein ATPase_2 PF01637.18 EMC84804.1 - 0.086 12.7 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RRP14 PF15459.6 EMC84804.1 - 0.14 12.8 0.2 0.46 11.1 0.0 1.9 2 0 0 2 2 2 0 60S ribosome biogenesis protein Rrp14 Abhydrolase_5 PF12695.7 EMC84804.1 - 0.21 11.3 0.0 0.39 10.5 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family RRP7 PF12923.7 EMC84805.1 - 1.9e-35 121.6 8.8 2.6e-35 121.1 8.8 1.2 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_1 PF00076.22 EMC84805.1 - 0.015 15.1 0.0 0.72 9.7 0.0 2.5 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RcsD_ABL PF16359.5 EMC84805.1 - 0.018 15.2 0.0 0.031 14.4 0.0 1.3 1 0 0 1 1 1 0 RcsD-ABL domain DUF5093 PF17011.5 EMC84805.1 - 0.032 14.5 0.6 0.077 13.3 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5093) Trans_reg_C PF00486.28 EMC84805.1 - 0.13 12.3 1.5 0.27 11.3 0.7 1.9 2 0 0 2 2 2 0 Transcriptional regulatory protein, C terminal RRM_1 PF00076.22 EMC84806.1 - 1.2e-10 41.1 0.0 3e-10 39.8 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Globin PF00042.22 EMC84807.1 - 4.1e-31 107.8 0.2 6.7e-31 107.1 0.1 1.4 2 0 0 2 2 2 1 Globin DUF3799 PF12684.7 EMC84807.1 - 0.024 14.4 0.3 0.029 14.2 0.3 1.1 1 0 0 1 1 1 0 PDDEXK-like domain of unknown function (DUF3799) BEN PF10523.9 EMC84807.1 - 0.042 14.1 0.1 0.095 12.9 0.0 1.7 2 0 0 2 2 2 0 BEN domain IL12 PF03039.14 EMC84807.1 - 0.056 12.8 0.0 0.072 12.4 0.0 1.3 1 0 0 1 1 1 0 Interleukin-12 alpha subunit Sulfotransfer_3 PF13469.6 EMC84807.1 - 0.14 12.5 0.0 0.21 12.0 0.0 1.3 1 1 0 1 1 1 0 Sulfotransferase family TPR_19 PF14559.6 EMC84808.1 - 6.5e-18 65.0 11.1 9.8e-06 26.0 0.4 6.3 6 1 1 7 7 6 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC84808.1 - 2.4e-11 43.7 20.4 0.002 18.3 0.2 5.5 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 EMC84808.1 - 1.9e-08 33.8 30.2 0.032 14.4 0.3 8.8 10 0 0 10 10 8 4 Tetratricopeptide repeat TPR_14 PF13428.6 EMC84808.1 - 4.8e-08 33.2 9.2 1.3 10.1 0.0 6.9 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMC84808.1 - 5.5e-08 32.4 7.9 0.0053 16.9 0.0 5.9 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 EMC84808.1 - 2.9e-06 27.3 2.2 0.0053 16.9 0.2 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EMC84808.1 - 1.8e-05 25.3 7.9 0.2 12.4 0.4 5.9 5 2 0 6 6 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMC84808.1 - 3e-05 24.4 10.8 0.27 11.9 0.0 7.5 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_17 PF13431.6 EMC84808.1 - 7.4e-05 22.9 4.8 0.021 15.2 0.0 5.3 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 EMC84808.1 - 0.00023 21.0 11.4 1.1 9.5 0.3 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMC84808.1 - 0.00052 20.2 13.2 1.1 9.6 0.0 6.2 5 2 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMC84808.1 - 0.00057 19.6 22.6 0.012 15.4 0.0 6.2 7 0 0 7 7 6 3 Tetratricopeptide repeat PPR PF01535.20 EMC84808.1 - 0.0012 18.9 0.4 5.8 7.4 0.0 4.5 4 0 0 4 4 4 1 PPR repeat TPR_4 PF07721.14 EMC84808.1 - 0.0027 18.2 0.0 27 5.8 0.0 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 EMC84808.1 - 0.0073 16.0 0.1 0.072 12.8 0.0 2.7 2 0 0 2 2 2 1 TPR repeat PPR_2 PF13041.6 EMC84808.1 - 0.026 14.7 0.4 5.3 7.3 0.1 3.4 3 1 1 4 4 4 0 PPR repeat family Fis1_TPR_C PF14853.6 EMC84808.1 - 0.086 12.9 4.5 1.1 9.4 0.1 3.8 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat FMN_red PF03358.15 EMC84808.1 - 0.12 12.1 0.0 0.29 10.9 0.0 1.6 1 0 0 1 1 1 0 NADPH-dependent FMN reductase TPR_10 PF13374.6 EMC84808.1 - 0.79 9.7 14.3 20 5.2 0.1 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat Guanylate_cyc PF00211.20 EMC84809.1 - 8.7e-67 224.3 0.1 2.3e-66 222.9 0.0 1.7 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Pkinase_Tyr PF07714.17 EMC84809.1 - 4e-36 124.6 0.1 1e-35 123.3 0.1 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC84809.1 - 4.6e-29 101.6 0.1 1.1e-28 100.4 0.1 1.6 1 0 0 1 1 1 1 Protein kinase domain ANF_receptor PF01094.28 EMC84809.1 - 5.2e-06 25.8 0.0 7.3e-05 22.0 0.0 2.1 1 1 0 1 1 1 1 Receptor family ligand binding region Phospholip_B PF04916.13 EMC84810.1 - 4.6e-187 622.8 2.4 5.1e-187 622.6 2.4 1.0 1 0 0 1 1 1 1 Phospholipase B ATF7IP_BD PF16788.5 EMC84811.1 - 1.3e-71 241.2 6.9 1.3e-71 241.2 6.9 4.6 4 2 2 6 6 6 1 ATF-interacting protein binding domain fn3_4 PF16794.5 EMC84811.1 - 1.5e-40 137.3 0.0 2.7e-40 136.4 0.0 1.4 1 0 0 1 1 1 1 Fibronectin-III type domain DUF1992 PF09350.10 EMC84811.1 - 0.013 15.7 0.3 0.035 14.3 0.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1992) 7tm_2 PF00002.24 EMC84812.1 - 1.4e-86 289.8 12.3 1.8e-86 289.5 12.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 EMC84812.1 - 4.3e-22 78.2 2.2 4.3e-22 78.2 2.2 2.3 2 0 0 2 2 2 1 Hormone receptor domain DUF1129 PF06570.11 EMC84812.1 - 0.21 11.1 1.4 0.71 9.3 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) Bromodomain PF00439.25 EMC84814.1 - 1.4e-10 41.1 0.9 2.6e-10 40.2 0.2 1.9 2 0 0 2 2 2 1 Bromodomain PWWP PF00855.17 EMC84814.1 - 3.7e-10 40.1 0.4 3.7e-10 40.1 0.4 3.7 3 1 0 3 3 3 1 PWWP domain zf-MYND PF01753.18 EMC84814.1 - 0.016 15.3 22.1 0.016 15.3 22.1 4.0 3 1 0 3 3 3 0 MYND finger AMP-binding PF00501.28 EMC84815.1 - 7.8e-97 324.5 0.0 7.7e-74 248.8 0.0 2.6 2 1 0 2 2 2 2 AMP-binding enzyme DMAP_binding PF06464.11 EMC84815.1 - 8.1e-13 49.2 2.2 1.4e-12 48.4 2.2 1.4 1 0 0 1 1 1 1 DMAP1-binding Domain CDO_I PF05995.12 EMC84816.1 - 0.069 12.5 0.0 0.082 12.2 0.0 1.1 1 0 0 1 1 1 0 Cysteine dioxygenase type I La PF05383.17 EMC84817.1 - 3.9e-14 52.4 0.2 8.8e-14 51.3 0.2 1.6 1 0 0 1 1 1 1 La domain NUDIX PF00293.28 EMC84818.1 - 2e-25 89.3 0.0 2.7e-25 88.9 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain WD40 PF00400.32 EMC84819.1 - 1.1e-26 92.5 24.4 5.3e-07 30.2 0.4 6.8 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC84819.1 - 0.01 16.1 3.5 3.6 7.9 0.1 4.2 4 2 1 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMC84819.1 - 0.012 14.3 5.5 2.9 6.4 0.1 3.2 2 1 1 3 3 3 0 Nucleoporin Nup120/160 DUF1640 PF07798.11 EMC84819.1 - 0.13 12.3 2.3 0.21 11.6 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) FAM76 PF16046.5 EMC84819.1 - 1.2 8.4 5.2 2 7.7 5.2 1.2 1 0 0 1 1 1 0 FAM76 protein A_deamin PF02137.18 EMC84820.1 - 1.3e-109 366.6 0.1 2e-109 366.0 0.1 1.3 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain dsrm PF00035.26 EMC84820.1 - 1.9e-24 86.1 0.2 4e-11 43.5 0.0 2.9 2 0 0 2 2 2 2 Double-stranded RNA binding motif DND1_DSRM PF14709.7 EMC84820.1 - 0.06 13.6 1.1 3.2 8.1 0.0 3.0 2 1 0 2 2 2 0 double strand RNA binding domain from DEAD END PROTEIN 1 Peptidase_M24 PF00557.24 EMC84822.1 - 2.2e-53 181.0 0.4 2.8e-53 180.7 0.4 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 EMC84822.1 - 0.0043 17.3 1.1 0.0043 17.3 1.1 1.9 2 0 0 2 2 2 1 zf-MYND-like zinc finger, mRNA-binding Pyr_redox_dim PF02852.22 EMC84822.1 - 0.021 15.1 0.2 0.037 14.3 0.2 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain ATP-cone PF03477.16 EMC84822.1 - 0.19 12.3 0.0 2.3 8.8 0.0 2.2 2 0 0 2 2 2 0 ATP cone domain IF4E PF01652.18 EMC84823.1 - 3e-56 189.6 0.2 3.6e-56 189.3 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Tetraspanin PF00335.20 EMC84824.1 - 3e-62 210.3 9.7 3.5e-62 210.1 9.7 1.0 1 0 0 1 1 1 1 Tetraspanin family Arm PF00514.23 EMC84825.1 - 1.6e-34 116.9 19.8 2.2e-08 33.9 0.2 8.3 7 1 1 8 8 8 5 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EMC84825.1 - 0.011 16.3 7.9 1.7 9.2 0.1 4.9 4 0 0 4 4 4 0 HEAT-like repeat Nitr_red_bet_C PF14711.6 EMC84825.1 - 0.075 12.7 0.0 0.22 11.2 0.0 1.8 1 0 0 1 1 1 0 Respiratory nitrate reductase beta C-terminal HEAT PF02985.22 EMC84825.1 - 0.092 13.1 2.4 10 6.7 0.1 4.6 3 1 0 3 3 3 0 HEAT repeat UPA PF17217.3 EMC84826.1 - 8e-72 239.7 0.4 1.5e-71 238.8 0.4 1.4 1 0 0 1 1 1 1 UPA domain ZU5 PF00791.20 EMC84826.1 - 4e-34 116.9 0.0 9.8e-34 115.6 0.0 1.7 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 EMC84826.1 - 1.4e-14 54.0 0.2 4e-14 52.5 0.0 1.9 2 0 0 2 2 2 1 Death domain Ig_3 PF13927.6 EMC84826.1 - 1.5e-13 51.1 0.3 4e-09 37.0 0.0 3.6 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 EMC84826.1 - 2.5e-12 46.7 1.9 6.7e-11 42.1 0.1 3.2 3 0 0 3 3 3 1 Immunoglobulin I-set domain TSP_1 PF00090.19 EMC84826.1 - 5.9e-10 39.2 28.1 4.3e-08 33.3 8.8 2.8 2 0 0 2 2 2 2 Thrombospondin type 1 domain Ig_2 PF13895.6 EMC84826.1 - 5.7e-08 33.0 0.1 7.8e-06 26.1 0.0 3.5 3 0 0 3 3 3 1 Immunoglobulin domain ig PF00047.25 EMC84826.1 - 9e-07 29.0 0.0 3.8e-05 23.8 0.0 3.1 3 0 0 3 3 3 1 Immunoglobulin domain V-set PF07686.17 EMC84826.1 - 0.013 15.6 0.4 1.9 8.7 0.1 3.2 2 1 0 2 2 2 0 Immunoglobulin V-set domain AtuA PF07287.11 EMC84826.1 - 0.033 12.9 0.0 0.056 12.2 0.0 1.2 1 0 0 1 1 1 0 Acyclic terpene utilisation family protein AtuA Pkinase_Tyr PF07714.17 EMC84827.1 - 2.6e-37 128.5 0.0 3.5e-37 128.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC84827.1 - 1.3e-35 123.0 0.0 2.1e-35 122.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.12 EMC84827.1 - 4.8e-16 57.9 0.5 1e-15 56.9 0.5 1.6 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Activin_recp PF01064.23 EMC84827.1 - 1.2e-13 51.9 10.9 1.2e-13 51.9 10.9 1.8 2 0 0 2 2 2 1 Activin types I and II receptor domain FTA2 PF13095.6 EMC84827.1 - 0.0093 15.6 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 LRRC37AB_C PF14914.6 EMC84827.1 - 0.077 12.9 0.0 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain Haspin_kinase PF12330.8 EMC84827.1 - 0.12 11.3 0.0 0.2 10.6 0.0 1.5 1 1 0 1 1 1 0 Haspin like kinase domain LIM PF00412.22 EMC84828.1 - 3e-40 136.2 28.2 4.1e-14 52.5 4.3 3.5 3 0 0 3 3 3 3 LIM domain PDZ PF00595.24 EMC84828.1 - 1.1e-12 48.1 0.0 2.1e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain DUF4749 PF15936.5 EMC84828.1 - 4e-08 34.3 0.0 7.7e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) PDZ_6 PF17820.1 EMC84828.1 - 8.1e-05 22.4 0.1 0.00017 21.4 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC84828.1 - 0.024 15.0 0.0 0.045 14.1 0.0 1.4 1 0 0 1 1 1 0 PDZ domain 7tm_1 PF00001.21 EMC84829.1 - 1.9e-53 181.5 17.4 2.3e-53 181.2 17.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC84829.1 - 1.6e-17 63.8 14.3 2e-17 63.4 14.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC84829.1 - 3.5e-14 53.1 17.9 5.4e-14 52.4 17.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC84829.1 - 6.4e-06 26.1 7.1 6.4e-06 26.1 7.1 2.6 2 1 0 2 2 2 1 Olfactory receptor CcmH PF03918.14 EMC84829.1 - 0.17 11.2 0.2 0.41 9.9 0.0 1.7 2 0 0 2 2 2 0 Cytochrome C biogenesis protein SNARE PF05739.19 EMC84829.1 - 0.79 9.8 3.4 12 6.0 0.4 2.5 2 0 0 2 2 2 0 SNARE domain DUF4282 PF14110.6 EMC84829.1 - 8.2 7.2 12.0 0.56 11.0 0.8 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4282) GST_C_3 PF14497.6 EMC84830.1 - 4.2e-17 62.2 0.0 6.8e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EMC84830.1 - 1.3e-13 51.0 0.0 2.9e-13 49.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EMC84830.1 - 2.2e-07 31.0 0.1 3.3e-07 30.4 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EMC84830.1 - 9.7e-05 22.7 0.0 0.00022 21.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EMC84830.1 - 0.00055 20.2 0.0 0.0011 19.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 EMC84830.1 - 0.0059 17.3 0.0 0.011 16.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 EMC84830.1 - 0.012 15.6 0.9 0.073 13.1 0.9 2.5 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EMC84830.1 - 0.026 14.3 0.1 0.074 12.9 0.1 1.9 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Synuclein PF01387.17 EMC84831.1 - 2.4e-55 186.4 16.1 2.8e-55 186.2 16.1 1.0 1 0 0 1 1 1 1 Synuclein C1q PF00386.21 EMC84833.1 - 1.3e-25 90.0 0.3 1.2e-24 87.0 0.1 2.8 2 0 0 2 2 2 1 C1q domain EMI PF07546.13 EMC84833.1 - 8.3e-14 52.1 4.4 8.3e-14 52.1 4.4 2.3 2 0 0 2 2 2 1 EMI domain EGF PF00008.27 EMC84833.1 - 1.1e-06 28.8 7.3 2.4e-06 27.7 7.3 1.6 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 EMC84833.1 - 0.018 15.6 6.5 0.048 14.3 6.5 1.8 1 0 0 1 1 1 0 Human growth factor-like EGF BclA_C PF18573.1 EMC84833.1 - 0.09 12.7 0.2 0.27 11.2 0.2 1.8 1 0 0 1 1 1 0 BclA C-terminal domain EGF_CA PF07645.15 EMC84833.1 - 0.24 11.6 5.9 0.8 10.0 5.9 1.8 1 0 0 1 1 1 0 Calcium-binding EGF domain YvrJ PF12841.7 EMC84833.1 - 0.39 10.3 4.9 0.57 9.8 0.2 3.6 3 0 0 3 3 3 0 YvrJ protein family FUSC PF04632.12 EMC84833.1 - 0.59 8.6 1.1 1.5 7.2 1.1 1.6 1 0 0 1 1 1 0 Fusaric acid resistance protein family Laminin_II PF06009.12 EMC84833.1 - 1.2 9.2 46.0 0.065 13.2 5.1 7.7 6 2 2 8 8 8 0 Laminin Domain II TMF_DNA_bd PF12329.8 EMC84835.1 - 0.003 17.5 1.4 0.0054 16.7 1.4 1.5 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding ANF_receptor PF01094.28 EMC84836.1 - 0.0032 16.6 0.0 0.0034 16.5 0.0 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region c-SKI_SMAD_bind PF08782.10 EMC84837.1 - 0.071 13.3 0.9 10 6.5 0.1 2.5 2 1 0 2 2 2 0 c-SKI Smad4 binding domain AP3D1 PF06375.11 EMC84837.1 - 1.8 8.7 19.3 0.7 10.1 12.3 2.3 2 1 0 2 2 2 0 AP-3 complex subunit delta-1 HrpJ PF07201.11 EMC84837.1 - 1.9 8.8 13.0 0.36 11.1 7.8 2.1 1 1 0 2 2 2 0 HrpJ-like domain Ctr PF04145.15 EMC84837.1 - 2.7 8.6 4.5 3.7 8.2 4.3 1.5 1 1 0 1 1 1 0 Ctr copper transporter family Presenilin PF01080.17 EMC84837.1 - 5.5 5.6 6.1 6.1 5.5 6.1 1.3 1 0 0 1 1 1 0 Presenilin C2 PF00168.30 EMC84838.1 - 3.4e-19 69.0 0.1 1.8e-18 66.7 0.0 2.2 2 0 0 2 2 2 1 C2 domain RBD-FIP PF09457.10 EMC84838.1 - 1.6e-16 59.9 3.0 3.7e-16 58.8 3.0 1.7 1 0 0 1 1 1 1 FIP domain Homeodomain PF00046.29 EMC84839.1 - 7.9e-22 76.9 2.6 1.4e-21 76.0 2.6 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC84839.1 - 0.018 14.9 0.0 0.06 13.3 0.0 1.9 1 0 0 1 1 1 0 Homeobox KN domain DUF874 PF05917.11 EMC84839.1 - 0.056 12.5 1.7 0.097 11.7 1.7 1.3 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) PDZ_6 PF17820.1 EMC84840.1 - 7.1e-12 45.0 0.1 1.5e-11 44.0 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC84840.1 - 1.1e-08 35.2 0.1 2.7e-08 34.0 0.1 1.6 1 0 0 1 1 1 1 PDZ domain C1_1 PF00130.22 EMC84840.1 - 1.3e-07 31.4 15.1 2.9e-07 30.3 15.1 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PDZ PF00595.24 EMC84840.1 - 2.9e-07 30.7 0.2 7.7e-07 29.4 0.2 1.7 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 EMC84840.1 - 0.0075 16.6 0.1 0.014 15.7 0.1 1.3 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain Glyco_hydro_67N PF03648.14 EMC84840.1 - 0.096 13.0 0.0 0.27 11.5 0.0 1.8 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 N-terminus MFS_1 PF07690.16 EMC84841.1 - 6.8e-46 156.8 35.7 5.4e-39 134.1 25.4 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMC84841.1 - 2.9e-11 42.9 23.9 1.5e-09 37.2 1.6 2.7 1 1 2 3 3 3 2 Sugar (and other) transporter LacY_symp PF01306.19 EMC84841.1 - 0.0031 16.3 16.3 0.007 15.2 6.9 2.9 2 1 0 2 2 2 2 LacY proton/sugar symporter SAYSvFN PF10260.9 EMC84841.1 - 0.68 9.9 3.0 0.44 10.5 0.2 2.3 2 0 0 2 2 2 0 Uncharacterized conserved domain (SAYSvFN) CPP1-like PF11833.8 EMC84841.1 - 1.4 8.5 3.5 3.9 7.1 3.5 1.8 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Ion_trans_2 PF07885.16 EMC84842.1 - 1.6e-29 101.7 23.3 3.6e-18 65.3 4.9 2.9 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 EMC84842.1 - 0.0017 17.6 20.7 0.014 14.7 5.4 2.6 2 1 0 2 2 2 2 Ion transport protein PIRT PF15099.6 EMC84842.1 - 0.15 11.7 1.1 1.1 8.9 0.2 2.8 3 1 0 3 3 3 0 Phosphoinositide-interacting protein family Homeodomain PF00046.29 EMC84843.1 - 5.4e-13 48.6 1.8 7.5e-13 48.1 1.8 1.2 1 0 0 1 1 1 1 Homeodomain HTH_AsnC-type PF13404.6 EMC84843.1 - 0.12 12.2 0.1 0.9 9.4 0.0 2.2 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain Enolase_C PF00113.22 EMC84845.1 - 2.2e-23 82.9 0.0 7.7e-23 81.2 0.0 1.9 1 1 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EMC84845.1 - 5.9e-14 52.4 0.4 8.4e-09 35.7 0.2 2.4 2 0 0 2 2 2 2 Enolase, N-terminal domain Kin17_mid PF10357.9 EMC84845.1 - 0.019 14.8 0.7 0.039 13.9 0.7 1.5 1 0 0 1 1 1 0 Domain of Kin17 curved DNA-binding protein PP2C_2 PF13672.6 EMC84845.1 - 0.22 11.1 0.2 0.36 10.4 0.2 1.2 1 0 0 1 1 1 0 Protein phosphatase 2C HSP70 PF00012.20 EMC84846.1 - 9.1e-07 27.4 0.0 0.033 12.4 0.0 3.2 3 0 0 3 3 3 3 Hsp70 protein GA-like PF17573.2 EMC84846.1 - 0.058 13.3 0.1 0.12 12.4 0.1 1.5 1 0 0 1 1 1 0 GA-like domain FGGY_C PF02782.16 EMC84846.1 - 0.18 11.5 0.0 0.34 10.6 0.0 1.4 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Lipase PF00151.19 EMC84847.1 - 2.1e-142 474.4 0.0 2.5e-142 474.1 0.0 1.1 1 0 0 1 1 1 1 Lipase PLAT PF01477.23 EMC84847.1 - 5e-12 46.4 0.1 9.8e-12 45.5 0.1 1.5 1 0 0 1 1 1 1 PLAT/LH2 domain DUF900 PF05990.12 EMC84847.1 - 0.027 14.0 0.0 0.041 13.4 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_6 PF12697.7 EMC84847.1 - 0.048 14.3 0.1 0.13 12.9 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMC84847.1 - 0.068 12.4 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Sdh_cyt PF01127.22 EMC84847.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Lipase PF00151.19 EMC84848.1 - 7.2e-118 393.7 0.0 8.9e-118 393.4 0.0 1.1 1 0 0 1 1 1 1 Lipase Abhydrolase_6 PF12697.7 EMC84848.1 - 1.3e-05 25.9 0.1 1.8e-05 25.4 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family PLAT PF01477.23 EMC84848.1 - 0.00061 20.3 0.3 0.0024 18.4 0.2 1.9 2 0 0 2 2 2 1 PLAT/LH2 domain Myticin-prepro PF10690.9 EMC84848.1 - 0.032 14.5 0.5 0.06 13.6 0.5 1.4 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel DUF900 PF05990.12 EMC84848.1 - 0.071 12.6 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Lipase PF00151.19 EMC84849.1 - 8.6e-115 383.6 0.0 1e-114 383.4 0.0 1.1 1 0 0 1 1 1 1 Lipase Abhydrolase_6 PF12697.7 EMC84849.1 - 0.0016 19.1 0.3 0.0024 18.5 0.3 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMC84849.1 - 0.017 14.4 0.0 0.025 13.8 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Rab5-bind PF09311.11 EMC84850.1 - 3e-05 23.6 13.3 3e-05 23.6 13.3 2.4 1 1 0 2 2 2 1 Rabaptin-like protein ATG16 PF08614.11 EMC84850.1 - 0.0011 19.2 19.9 0.0011 19.2 19.9 2.4 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) DUF5113 PF17140.4 EMC84850.1 - 0.0081 16.0 0.8 0.0081 16.0 0.8 2.1 3 1 1 4 4 4 1 Domain of unknown function (DUF5113) DUF3450 PF11932.8 EMC84850.1 - 0.11 11.8 25.2 0.021 14.1 8.1 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF3450) USP8_interact PF08941.10 EMC84850.1 - 0.17 11.7 13.2 1.9 8.3 2.2 2.8 2 1 0 2 2 2 0 USP8 interacting HR1 PF02185.16 EMC84850.1 - 0.74 10.0 22.2 0.19 11.9 3.5 3.9 2 1 1 3 3 3 0 Hr1 repeat Imm70 PF15601.6 EMC84850.1 - 0.87 9.1 6.0 0.29 10.7 0.2 2.8 1 1 1 3 3 3 0 Immunity protein 70 Serine_rich PF08824.10 EMC84850.1 - 0.92 9.5 13.4 0.45 10.5 7.5 2.4 1 1 1 2 2 2 0 Serine rich protein interaction domain Syntaxin-6_N PF09177.11 EMC84850.1 - 1.7 9.2 21.7 0.052 14.1 7.0 3.2 2 2 1 3 3 3 0 Syntaxin 6, N-terminal HAUS-augmin3 PF14932.6 EMC84850.1 - 3.6 7.1 35.1 2.2 7.8 12.4 2.6 1 1 2 3 3 3 0 HAUS augmin-like complex subunit 3 Spc7 PF08317.11 EMC84850.1 - 3.6 6.4 40.4 3.9 6.3 15.8 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein GAS PF13851.6 EMC84850.1 - 5 6.4 43.1 8.3 5.7 25.4 2.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF5082 PF16888.5 EMC84850.1 - 6 7.2 27.4 7.9 6.8 8.8 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) TPR_MLP1_2 PF07926.12 EMC84850.1 - 8.5 6.5 37.9 0.37 10.9 11.3 3.9 1 1 4 5 5 5 0 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.9 EMC84850.1 - 9.4 6.3 42.2 0.04 13.9 22.8 2.9 1 1 1 2 2 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GDNF PF02351.16 EMC84851.1 - 1.8e-37 128.1 53.5 1.1e-20 74.4 6.8 3.5 4 0 0 4 4 4 3 GDNF/GAS1 domain Kelch_5 PF13854.6 EMC84852.1 - 6.8e-27 93.0 18.4 5e-08 32.8 0.0 6.7 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 EMC84852.1 - 2.4e-21 75.5 6.4 4.4e-05 23.4 0.1 6.1 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_1 PF01344.25 EMC84852.1 - 9.7e-21 73.1 15.1 7.1e-05 22.3 0.0 6.6 7 0 0 7 7 7 5 Kelch motif Kelch_6 PF13964.6 EMC84852.1 - 1.3e-18 66.5 13.8 1.9e-05 24.8 0.0 6.5 6 0 0 6 6 6 5 Kelch motif PSI PF01437.25 EMC84852.1 - 5.1e-18 65.4 53.9 9.8e-13 48.4 9.5 9.1 8 1 0 8 8 5 5 Plexin repeat Lectin_C PF00059.21 EMC84852.1 - 9e-16 58.6 0.1 9e-16 58.6 0.1 3.4 3 1 0 3 3 1 1 Lectin C-type domain Kelch_3 PF13415.6 EMC84852.1 - 8.4e-13 48.3 9.3 0.00056 20.1 0.0 6.6 6 0 0 6 6 6 4 Galactose oxidase, central domain CUB PF00431.20 EMC84852.1 - 7.2e-12 45.6 0.0 2e-11 44.2 0.0 1.8 1 0 0 1 1 1 1 CUB domain Kelch_2 PF07646.15 EMC84852.1 - 5.1e-11 42.1 12.6 0.039 14.0 0.0 5.8 6 0 0 6 6 5 3 Kelch motif EGF_2 PF07974.13 EMC84852.1 - 9.7e-05 22.7 10.2 9.7e-05 22.7 10.2 9.7 6 2 1 7 7 3 3 EGF-like domain Laminin_EGF PF00053.24 EMC84852.1 - 0.00012 22.2 18.3 0.00012 22.2 18.3 9.4 6 3 2 8 8 5 3 Laminin EGF domain PSI_integrin PF17205.3 EMC84852.1 - 0.00094 18.9 7.5 0.00094 18.9 7.5 7.0 7 0 0 7 7 5 2 Integrin plexin domain RAI16-like PF10257.9 EMC84853.1 - 7.1e-139 462.7 6.9 9.3e-139 462.3 6.9 1.2 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein AbLIM_anchor PF16182.5 EMC84854.1 - 4.7e-142 474.3 19.5 8.9e-142 473.3 19.5 1.5 1 0 0 1 1 1 1 Putative adherens-junction anchoring region of AbLIM LIM PF00412.22 EMC84854.1 - 3.7e-43 145.6 43.4 2.4e-14 53.3 1.6 5.0 4 1 1 5 5 5 4 LIM domain VHP PF02209.19 EMC84854.1 - 1.5e-15 56.9 1.2 2.7e-15 56.1 0.6 1.8 2 0 0 2 2 2 1 Villin headpiece domain PH PF00169.29 EMC84855.1 - 3.8e-23 82.0 1.9 1.8e-10 41.2 0.0 2.6 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 EMC84855.1 - 2.8e-08 34.1 4.8 0.004 17.6 0.1 3.9 3 1 0 3 3 3 2 Pleckstrin homology domain UPF0242 PF06785.11 EMC84855.1 - 0.029 14.5 8.0 0.078 13.1 8.0 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Takusan PF04822.13 EMC84855.1 - 0.076 12.9 8.5 0.27 11.1 8.5 2.0 1 0 0 1 1 1 0 Takusan PH_8 PF15409.6 EMC84855.1 - 0.12 12.7 0.1 4.6 7.6 0.0 2.5 2 0 0 2 2 2 0 Pleckstrin homology domain DUF2730 PF10805.8 EMC84855.1 - 0.41 10.8 5.3 1.3 9.1 0.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2730) DUF4407 PF14362.6 EMC84855.1 - 2.4 7.5 6.5 5.2 6.3 6.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FapA PF03961.13 EMC84855.1 - 3.4 6.2 7.9 5.7 5.4 7.9 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A TMPIT PF07851.13 EMC84855.1 - 9.3 5.4 5.7 16 4.6 5.7 1.3 1 0 0 1 1 1 0 TMPIT-like protein VWA PF00092.28 EMC84856.1 - 3.2e-93 310.8 0.0 3.3e-36 125.1 0.0 3.1 3 0 0 3 3 3 3 von Willebrand factor type A domain VWA_2 PF13519.6 EMC84856.1 - 1.8e-34 118.6 0.0 8.3e-14 52.1 0.0 3.5 3 0 0 3 3 3 3 von Willebrand factor type A domain EGF PF00008.27 EMC84856.1 - 6.4e-13 48.7 25.4 2.5e-07 30.9 10.1 2.8 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.7 EMC84856.1 - 2.5e-07 31.1 19.0 9.8e-05 22.8 5.8 3.0 2 0 0 2 2 2 2 Human growth factor-like EGF EGF_2 PF07974.13 EMC84856.1 - 1.2 9.5 30.4 2.1 8.8 10.5 2.8 2 0 0 2 2 2 0 EGF-like domain TUDOR PF00567.24 EMC84857.1 - 3.9e-96 317.5 6.0 1.6e-36 125.0 0.0 4.6 4 1 0 4 4 4 3 Tudor domain Agenet PF05641.12 EMC84857.1 - 1.6e-09 38.1 3.1 0.0095 16.4 0.1 4.0 4 0 0 4 4 4 3 Agenet domain SMN PF06003.12 EMC84857.1 - 1.8e-08 34.0 0.1 7.9e-05 22.0 0.0 2.5 2 0 0 2 2 2 2 Survival motor neuron protein (SMN) DUF4537 PF15057.6 EMC84857.1 - 1.2e-06 28.5 0.0 0.2 11.7 0.0 3.5 3 0 0 3 3 3 3 Domain of unknown function (DUF4537) Tudor_4 PF18358.1 EMC84857.1 - 5.1e-05 22.8 1.3 0.0018 17.8 0.0 3.1 3 0 0 3 3 3 1 Histone methyltransferase Tudor domain Spore_coat_CotO PF14153.6 EMC84857.1 - 0.0006 19.8 0.0 1.2 9.0 0.0 3.2 3 0 0 3 3 3 1 Spore coat protein CotO SNase PF00565.17 EMC84857.1 - 0.0024 18.3 0.0 2.4 8.7 0.0 2.6 2 0 0 2 2 2 2 Staphylococcal nuclease homologue PCB_OB PF17092.5 EMC84857.1 - 0.0029 18.3 0.0 1.1 10.0 0.0 3.5 4 0 0 4 4 4 1 Penicillin-binding protein OB-like domain BRE1 PF08647.11 EMC84858.1 - 0.013 15.5 8.5 0.013 15.5 8.5 9.3 6 2 5 11 11 11 0 BRE1 E3 ubiquitin ligase TPR_MLP1_2 PF07926.12 EMC84858.1 - 0.73 9.9 129.5 0.046 13.8 21.4 8.5 3 1 6 9 9 9 0 TPR/MLP1/MLP2-like protein Toxin_21 PF08091.11 EMC84859.1 - 0.031 14.2 1.1 1.4 8.9 0.0 2.7 2 0 0 2 2 2 0 Spider insecticidal peptide 7tm_1 PF00001.21 EMC84860.1 - 1.1e-79 267.5 5.6 1.3e-79 267.2 5.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC84860.1 - 3.8e-16 59.2 2.7 5.4e-16 58.7 2.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 EMC84860.1 - 2.9e-09 36.7 0.2 2.9e-09 36.7 0.2 1.5 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 EMC84860.1 - 7.9e-07 29.1 10.2 1.4e-05 25.0 7.8 2.4 2 1 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC84860.1 - 1.1e-06 28.5 5.6 1.1e-06 28.5 5.6 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx S_4TM PF18159.1 EMC84860.1 - 0.18 11.1 0.0 0.18 11.1 0.0 2.4 3 0 0 3 3 3 0 SMODS-associating 4TM effector domain LapA_dom PF06305.11 EMC84860.1 - 1 9.2 0.0 1 9.2 0.0 3.3 5 0 0 5 5 5 0 Lipopolysaccharide assembly protein A domain Vpu PF00558.19 EMC84860.1 - 2.1 8.2 3.4 2.3 8.0 0.1 2.4 2 0 0 2 2 2 0 Vpu protein DRMBL PF07522.14 EMC84861.1 - 5.1e-34 116.8 0.5 2.1e-33 114.8 0.0 2.3 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 EMC84861.1 - 0.00026 20.6 0.0 0.00046 19.8 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EMC84861.1 - 0.026 14.5 0.0 0.05 13.6 0.0 1.5 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily RMMBL PF07521.12 EMC84861.1 - 0.037 14.0 0.0 0.098 12.6 0.0 1.6 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain PH PF00169.29 EMC84862.1 - 8.7e-10 39.1 0.1 1.7e-09 38.1 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EMC84862.1 - 0.00036 20.9 0.2 0.0018 18.7 0.2 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 EMC84862.1 - 0.0035 17.6 0.2 0.23 11.8 0.2 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 EMC84862.1 - 0.015 15.4 0.2 0.13 12.4 0.0 2.4 2 1 0 2 2 2 0 PH domain SCHIP-1 PF10148.9 EMC84862.1 - 0.15 11.6 0.1 0.27 10.8 0.1 1.3 1 0 0 1 1 1 0 Schwannomin-interacting protein 1 Peptidase_C14 PF00656.22 EMC84863.1 - 8.9e-56 189.6 0.0 1e-55 189.4 0.0 1.0 1 0 0 1 1 1 1 Caspase domain Mut7-C PF01927.16 EMC84863.1 - 0.017 15.3 0.1 0.051 13.7 0.0 1.8 2 0 0 2 2 2 0 Mut7-C RNAse domain TPP_enzyme_C PF02775.21 EMC84863.1 - 0.06 13.1 0.0 0.098 12.4 0.0 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Nebulin PF00880.18 EMC84864.1 - 9.5e-210 677.0 145.9 1.1e-08 34.8 0.3 41.6 42 0 0 42 42 42 41 Nebulin repeat ArfA PF03889.13 EMC84864.1 - 0.037 13.5 4.6 2.1 7.9 0.1 4.6 6 0 0 6 6 6 0 Alternative ribosome-rescue factor A DUF1510 PF07423.11 EMC84864.1 - 0.28 11.4 4.0 32 4.8 0.2 4.6 4 0 0 4 4 4 0 Domain of unknown function (DUF1510) OGG_N PF07934.12 EMC84864.1 - 0.48 10.5 4.3 0.92 9.6 0.3 3.3 3 0 0 3 3 3 0 8-oxoguanine DNA glycosylase, N-terminal domain DUF3417 PF11897.8 EMC84864.1 - 1.6 9.2 24.7 0.5 10.8 1.1 7.8 7 1 1 8 8 8 0 Protein of unknown function (DUF3417) Trypsin PF00089.26 EMC84865.1 - 1.1e-66 224.9 0.8 1.4e-66 224.4 0.8 1.2 1 0 0 1 1 1 1 Trypsin Kringle PF00051.18 EMC84865.1 - 1.6e-21 76.4 4.5 1.6e-21 76.4 4.5 2.3 2 0 0 2 2 2 1 Kringle domain EGF PF00008.27 EMC84865.1 - 2.5e-14 53.2 43.1 1.9e-07 31.2 8.3 4.5 4 0 0 4 4 4 3 EGF-like domain Trypsin_2 PF13365.6 EMC84865.1 - 3.3e-05 24.8 0.0 7.1e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 EMC84865.1 - 0.00011 22.6 0.0 0.00021 21.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) EGF_2 PF07974.13 EMC84865.1 - 0.0073 16.6 39.6 0.019 15.3 9.6 4.6 3 0 0 3 3 3 2 EGF-like domain hEGF PF12661.7 EMC84865.1 - 0.048 14.3 2.5 0.048 14.3 2.5 6.0 6 0 0 6 6 6 0 Human growth factor-like EGF DUF5571 PF17732.1 EMC84866.1 - 2.3e-18 66.8 1.4 2.8e-18 66.5 1.4 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5571) zf-CCCH_3 PF15663.5 EMC84866.1 - 4.5e-10 39.7 0.1 3.6e-09 36.8 0.0 2.0 1 1 1 2 2 2 1 Zinc-finger containing family DUF5565 PF17720.1 EMC84867.1 - 2.7e-176 585.1 0.1 3.1e-176 585.0 0.1 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5565) CEP209_CC5 PF16574.5 EMC84868.1 - 2.2e-50 170.1 25.3 2.2e-50 170.1 25.3 21.1 12 8 5 18 18 18 3 Coiled-coil region of centrosome protein CE290 F-box-like_2 PF13013.6 EMC84868.1 - 0.01 15.8 1.2 0.087 12.8 0.1 3.3 2 0 0 2 2 2 0 F-box-like domain Tau95_N PF17682.1 EMC84868.1 - 0.53 10.5 12.6 0.07 13.3 2.5 4.9 2 1 0 2 2 2 0 Tau95 Triple barrel domain TPR_8 PF13181.6 EMC84869.1 - 4.2e-40 132.6 15.7 1.8e-06 27.7 0.1 9.4 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.17 EMC84869.1 - 1.1e-38 128.2 14.9 2.9e-08 33.2 0.2 9.7 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_1 PF00515.28 EMC84869.1 - 1.4e-37 125.9 20.9 2.9e-09 36.3 0.3 9.6 9 0 0 9 9 9 8 Tetratricopeptide repeat DUF1736 PF08409.11 EMC84869.1 - 8.4e-32 109.0 1.2 1.9e-31 107.8 1.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1736) TPR_17 PF13431.6 EMC84869.1 - 9.4e-27 91.4 27.0 3.3e-06 27.1 0.3 10.6 11 0 0 11 11 10 7 Tetratricopeptide repeat TPR_11 PF13414.6 EMC84869.1 - 2.8e-25 87.7 14.2 2.2e-05 24.1 0.7 8.4 5 3 3 8 8 8 6 TPR repeat TPR_16 PF13432.6 EMC84869.1 - 2.3e-20 72.9 1.1 6.1e-05 23.6 0.0 6.0 4 1 2 6 6 6 5 Tetratricopeptide repeat TPR_19 PF14559.6 EMC84869.1 - 4.4e-18 65.6 15.5 1.5e-06 28.6 1.5 6.8 2 1 7 9 9 9 5 Tetratricopeptide repeat TPR_12 PF13424.6 EMC84869.1 - 1.1e-17 64.0 14.1 0.0014 18.9 0.0 7.7 5 3 2 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 EMC84869.1 - 2.9e-15 55.7 7.1 0.00065 20.3 0.1 8.2 4 2 4 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.6 EMC84869.1 - 3.3e-10 40.0 0.6 0.00036 20.6 0.3 4.4 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 EMC84869.1 - 2.6e-08 33.3 7.9 3.5 7.9 0.1 7.4 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_6 PF13174.6 EMC84869.1 - 1.3e-07 31.8 15.2 0.33 11.7 0.0 8.2 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_10 PF13374.6 EMC84869.1 - 2.8e-07 30.2 15.3 0.44 10.5 0.0 6.7 7 0 0 7 7 7 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC84869.1 - 5.7e-07 29.7 5.9 0.085 13.1 0.4 4.6 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 ChAPs PF09295.10 EMC84869.1 - 0.0003 19.9 9.5 0.044 12.8 0.6 3.0 1 1 2 3 3 3 2 ChAPs (Chs5p-Arf1p-binding proteins) PMT_2 PF13231.6 EMC84869.1 - 0.011 16.0 6.2 0.011 16.0 6.2 2.4 2 1 0 2 2 2 0 Dolichyl-phosphate-mannose-protein mannosyltransferase TPR_15 PF13429.6 EMC84869.1 - 0.19 10.9 10.0 0.095 11.9 4.5 2.6 1 1 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMC84869.1 - 0.2 11.8 2.8 23 5.1 0.1 4.2 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat Wzy_C_2 PF11846.8 EMC84869.1 - 0.74 9.7 5.4 0.25 11.2 0.2 2.9 4 0 0 4 4 4 0 Virulence factor membrane-bound polymerase, C-terminal DUF2929 PF11151.8 EMC84869.1 - 0.98 9.8 4.1 0.32 11.3 0.1 2.4 2 0 0 2 2 1 0 Protein of unknown function (DUF2929) EpsG PF14897.6 EMC84869.1 - 7.7 5.7 22.4 0.18 11.1 2.5 2.5 3 0 0 3 3 3 0 EpsG family SCF PF02404.15 EMC84870.1 - 4.9e-144 478.7 1.8 5.4e-144 478.5 1.8 1.0 1 0 0 1 1 1 1 Stem cell factor Elf1 PF05129.13 EMC84870.1 - 0.51 10.4 2.6 5 7.2 0.5 2.3 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like DSPc PF00782.20 EMC84871.1 - 3.2e-43 146.7 0.0 4.6e-43 146.2 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 EMC84871.1 - 4.5e-07 30.3 0.0 9.5e-05 22.9 0.0 2.4 1 1 0 1 1 1 1 Rhodanese-like domain Y_phosphatase PF00102.27 EMC84871.1 - 0.00037 20.1 0.0 0.00057 19.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 EMC84871.1 - 0.015 15.6 0.0 0.026 14.8 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain PTPlike_phytase PF14566.6 EMC84871.1 - 0.089 12.9 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate WD40 PF00400.32 EMC84872.1 - 4.6e-52 172.8 16.9 7.1e-09 36.2 0.0 6.8 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC84872.1 - 8.6e-23 80.5 0.2 0.0025 18.1 0.1 5.8 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMC84872.1 - 1.4e-11 43.9 0.1 0.071 12.1 0.0 5.3 1 1 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EMC84872.1 - 9.4e-09 35.4 0.1 1.3e-05 25.2 0.0 3.6 2 1 2 4 4 4 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EMC84872.1 - 2e-06 26.8 3.9 3 6.4 0.0 5.0 3 2 2 5 5 5 3 Nucleoporin Nup120/160 WD40_like PF17005.5 EMC84872.1 - 0.00095 18.6 0.0 2.4 7.4 0.0 3.3 3 1 1 4 4 4 2 WD40-like domain Proteasome_A_N PF10584.9 EMC84872.1 - 0.0095 15.6 0.0 8.6 6.1 0.0 3.2 2 0 0 2 2 2 2 Proteasome subunit A N-terminal signature Cytochrom_D1 PF02239.16 EMC84872.1 - 0.031 12.8 0.0 0.64 8.5 0.0 2.3 2 1 0 2 2 2 0 Cytochrome D1 heme domain PD40 PF07676.12 EMC84872.1 - 0.049 13.6 0.0 24 5.0 0.0 3.2 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Glycos_transf_2 PF00535.26 EMC84873.1 - 8e-35 120.1 0.0 1.4e-34 119.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 EMC84873.1 - 1.7e-22 80.0 0.0 2.7e-22 79.4 0.0 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 EMC84873.1 - 3.6e-05 23.8 0.0 6.4e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 EMC84873.1 - 4.6e-05 23.0 0.0 0.00011 21.8 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 EMC84873.1 - 0.0035 16.9 0.0 0.0082 15.6 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.6 EMC84873.1 - 0.009 16.7 0.0 0.022 15.5 0.0 1.6 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain-like Cation_ATPase_C PF00689.21 EMC84874.1 - 6.8e-45 153.0 3.8 6.8e-45 153.0 3.8 2.4 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EMC84874.1 - 3.3e-34 118.0 14.6 7.5e-26 90.8 1.5 2.9 3 0 0 3 3 3 2 E1-E2 ATPase ATP_Ca_trans_C PF12424.8 EMC84874.1 - 1.2e-28 99.4 3.7 2.9e-14 53.3 1.5 2.8 1 1 1 2 2 2 2 Plasma membrane calcium transporter ATPase C terminal Cation_ATPase PF13246.6 EMC84874.1 - 2e-17 63.1 0.0 4.2e-17 62.0 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EMC84874.1 - 3.2e-16 58.8 0.0 1.9e-15 56.3 0.0 2.3 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 EMC84874.1 - 5.4e-14 53.0 0.2 2.2e-12 47.7 0.2 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EMC84874.1 - 1e-05 25.4 5.4 0.00012 21.9 0.4 2.9 2 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase DUF2201_N PF13203.6 EMC84874.1 - 0.26 10.9 0.6 0.47 10.0 0.6 1.4 1 0 0 1 1 1 0 Putative metallopeptidase domain LRR_8 PF13855.6 EMC84875.1 - 5.7e-22 77.2 9.1 3.5e-11 42.7 0.4 3.7 3 1 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EMC84875.1 - 9.9e-08 32.2 16.8 0.012 16.0 0.3 4.7 1 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC84875.1 - 4.5e-07 29.5 6.8 2.5e-05 23.9 2.3 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LRRNT PF01462.18 EMC84875.1 - 9.1e-07 28.4 5.4 1.3e-06 27.9 0.8 2.7 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_5 PF13306.6 EMC84875.1 - 6.2e-06 26.2 0.1 0.00025 21.0 0.0 2.6 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EMC84875.1 - 8.8e-05 22.5 8.6 2.3 9.1 1.5 6.1 5 1 0 5 5 5 1 Leucine Rich Repeat LRR_6 PF13516.6 EMC84875.1 - 0.022 14.8 7.2 29 5.1 0.0 4.9 5 0 0 5 5 5 0 Leucine Rich repeat LRR_8 PF13855.6 EMC84876.1 - 3.1e-31 106.9 33.1 6.5e-09 35.4 1.8 6.8 4 2 2 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EMC84876.1 - 7.9e-20 70.6 28.4 0.0001 22.6 2.9 7.4 5 2 2 7 7 7 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EMC84876.1 - 4.8e-08 32.4 12.8 1.3 9.3 0.2 7.5 7 0 0 7 7 7 3 Leucine Rich repeat LRRNT PF01462.18 EMC84876.1 - 2.9e-06 26.8 4.3 8.8e-06 25.2 2.2 2.7 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.6 EMC84876.1 - 9.3e-06 25.2 14.1 0.0039 16.7 2.4 4.2 1 1 3 4 4 4 3 Leucine-rich repeat LRR_5 PF13306.6 EMC84876.1 - 9.7e-05 22.3 2.7 0.0049 16.8 0.9 3.0 2 1 1 3 3 3 1 BspA type Leucine rich repeat region (6 copies) CRT10 PF08728.10 EMC84876.1 - 0.007 14.6 0.0 0.01 14.1 0.0 1.2 1 0 0 1 1 1 1 CRT10 LRR_1 PF00560.33 EMC84876.1 - 0.074 13.6 32.0 18 6.4 0.2 10.3 10 2 1 11 11 11 0 Leucine Rich Repeat LRR_8 PF13855.6 EMC84877.1 - 4.7e-38 128.7 27.5 6.3e-11 41.9 1.6 5.8 3 1 2 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 EMC84877.1 - 3.1e-25 87.8 33.4 5.1e-06 26.7 1.2 6.3 1 1 4 6 6 6 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC84877.1 - 4.1e-09 35.7 21.8 4.9 8.1 0.0 9.1 7 2 0 7 7 7 4 Leucine Rich Repeat LRR_9 PF14580.6 EMC84877.1 - 2.1e-08 33.9 8.5 0.004 16.7 0.7 3.2 1 1 2 3 3 3 3 Leucine-rich repeat LRRNT PF01462.18 EMC84877.1 - 4.5e-08 32.6 2.3 4.5e-08 32.6 2.3 2.5 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_5 PF13306.6 EMC84877.1 - 1.7e-07 31.2 3.0 0.00053 19.9 0.2 3.1 2 1 1 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 EMC84877.1 - 8.9e-07 28.5 30.7 0.073 13.2 0.0 7.7 10 0 0 10 10 10 5 Leucine Rich repeat DUF4292 PF14125.6 EMC84877.1 - 0.039 13.6 2.4 4.1 7.0 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4292) LRR_8 PF13855.6 EMC84878.1 - 7.3e-38 128.1 22.6 4.6e-14 51.9 4.1 4.4 3 2 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EMC84878.1 - 7.1e-23 80.3 27.8 2.5e-05 24.6 3.7 6.6 1 1 7 8 8 8 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC84878.1 - 1.3e-12 47.7 6.0 1.3e-05 25.1 0.2 3.3 2 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC84878.1 - 2.1e-12 46.9 6.0 0.00019 21.0 3.5 3.2 1 1 2 3 3 3 3 Leucine-rich repeat LRRNT PF01462.18 EMC84878.1 - 3.2e-10 39.4 10.4 3.8e-10 39.2 5.5 3.0 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 EMC84878.1 - 8.9e-05 22.5 18.3 9.9 7.2 0.1 8.0 8 0 0 8 8 8 2 Leucine Rich Repeat LRR_6 PF13516.6 EMC84878.1 - 0.012 15.6 20.1 0.66 10.2 0.0 7.0 7 0 0 7 7 7 0 Leucine Rich repeat FNIP PF05725.12 EMC84878.1 - 0.091 13.0 5.5 8.9 6.6 0.1 3.5 2 1 0 2 2 2 0 FNIP Repeat BTG PF07742.12 EMC84879.1 - 7.1e-31 106.5 0.0 9e-31 106.1 0.0 1.1 1 0 0 1 1 1 1 BTG family RhoGEF PF00621.20 EMC84880.1 - 7.9e-18 65.3 2.2 7.9e-18 65.3 2.2 1.8 2 0 0 2 2 2 1 RhoGEF domain PH_13 PF16652.5 EMC84880.1 - 1.5e-07 31.3 2.1 0.0064 16.3 0.3 2.6 3 0 0 3 3 3 2 Pleckstrin homology domain PH_16 PF17838.1 EMC84880.1 - 7e-07 29.1 1.2 0.012 15.4 0.1 3.0 3 0 0 3 3 3 2 PH domain PH PF00169.29 EMC84880.1 - 0.0022 18.5 0.3 0.015 15.8 0.3 2.5 1 1 0 1 1 1 1 PH domain PH_5 PF15405.6 EMC84880.1 - 0.0027 17.8 6.4 0.0048 17.0 0.6 3.0 2 1 0 2 2 2 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 EMC84880.1 - 0.033 14.2 0.2 0.14 12.2 0.0 2.0 2 0 0 2 2 2 0 PH domain FYVE PF01363.21 EMC84881.1 - 2e-20 72.7 10.4 2e-20 72.7 10.4 2.2 2 0 0 2 2 2 1 FYVE zinc finger CENP-Q PF13094.6 EMC84881.1 - 0.00084 19.6 0.7 0.00084 19.6 0.7 14.6 2 1 12 14 14 14 1 CENP-Q, a CENPA-CAD centromere complex subunit CENP-F_leu_zip PF10473.9 EMC84881.1 - 0.0014 18.6 22.4 0.0014 18.6 22.4 14.9 4 2 11 15 15 15 7 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IBR PF01485.21 EMC84881.1 - 0.014 15.6 5.3 0.075 13.3 5.3 2.3 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Filament PF00038.21 EMC84881.1 - 0.45 10.0 283.9 0.19 11.3 48.5 11.1 1 1 9 10 10 10 0 Intermediate filament protein zf-RING_2 PF13639.6 EMC84881.1 - 1.8 9.0 11.5 3.3 8.1 9.4 2.4 2 0 0 2 2 2 0 Ring finger domain NUDIX PF00293.28 EMC84882.1 - 2.8e-16 59.7 0.4 3.3e-16 59.5 0.4 1.1 1 0 0 1 1 1 1 NUDIX domain UQ_con PF00179.26 EMC84883.1 - 1.1e-46 157.9 0.0 1.3e-46 157.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EMC84883.1 - 0.00072 19.3 0.0 0.00093 18.9 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EMC84883.1 - 0.0034 17.2 0.0 0.0056 16.5 0.0 1.4 1 0 0 1 1 1 1 UEV domain RWD PF05773.22 EMC84883.1 - 0.02 15.2 0.1 0.032 14.5 0.1 1.5 1 1 0 1 1 1 0 RWD domain MRP-S32 PF10210.9 EMC84884.1 - 2.5e-37 127.3 1.5 3e-37 127.1 1.5 1.1 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S32 Pathogen_betaC1 PF09593.10 EMC84884.1 - 0.016 15.1 0.0 0.02 14.8 0.0 1.1 1 0 0 1 1 1 0 Beta-satellite pathogenicity beta C1 protein CARD PF00619.21 EMC84885.1 - 1.7e-16 60.0 0.1 2.7e-16 59.4 0.1 1.3 1 0 0 1 1 1 1 Caspase recruitment domain Death PF00531.22 EMC84885.1 - 2.3e-13 50.1 0.2 2.3e-12 46.9 0.1 2.2 2 0 0 2 2 2 1 Death domain CARD_2 PF16739.5 EMC84885.1 - 0.0004 20.3 0.1 0.00089 19.2 0.1 1.5 1 0 0 1 1 1 1 Caspase recruitment domain Plexin_cytopl PF08337.12 EMC84886.1 - 1.1e-199 664.7 12.0 7.2e-197 655.4 12.0 2.2 1 1 0 1 1 1 1 Plexin cytoplasmic RasGAP domain TIG PF01833.24 EMC84886.1 - 5.2e-15 55.3 0.8 1.5e-07 31.4 0.0 2.8 2 0 0 2 2 2 2 IPT/TIG domain PSI PF01437.25 EMC84886.1 - 9.4e-09 35.7 10.0 9.4e-09 35.7 10.0 2.7 2 0 0 2 2 2 1 Plexin repeat DUF561 PF04481.12 EMC84886.1 - 0.0074 15.5 0.0 0.017 14.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF561) Sema PF01403.19 EMC84886.1 - 0.025 13.4 1.8 0.031 13.1 0.0 1.9 1 1 1 2 2 2 0 Sema domain Tmemb_cc2 PF10267.9 EMC84887.1 - 3.6e-162 540.1 12.7 4.1e-162 539.9 12.7 1.0 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein Rootletin PF15035.6 EMC84887.1 - 0.0055 16.7 0.2 0.0055 16.7 0.2 3.4 2 1 1 3 3 2 1 Ciliary rootlet component, centrosome cohesion DUF2407_C PF13373.6 EMC84887.1 - 0.019 15.2 0.2 0.019 15.2 0.2 2.1 2 0 0 2 2 2 0 DUF2407 C-terminal domain FlxA PF14282.6 EMC84887.1 - 0.019 14.9 5.4 0.019 14.9 5.4 4.2 3 1 1 4 4 3 0 FlxA-like protein DUF4735 PF15882.5 EMC84887.1 - 0.063 12.7 11.0 0.28 10.6 1.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4735) Exonuc_VII_L PF02601.15 EMC84887.1 - 0.18 11.3 19.0 1.2 8.7 9.2 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit Myb_DNA-bind_3 PF12776.7 EMC84887.1 - 0.72 10.9 3.7 5.5 8.0 0.0 3.0 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain V_ATPase_I PF01496.19 EMC84887.1 - 0.86 7.4 14.6 0.85 7.5 3.0 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family CorA PF01544.18 EMC84887.1 - 2.1 7.6 14.6 2 7.6 1.0 2.2 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Lipoprotein_20 PF13942.6 EMC84887.1 - 2.8 7.8 17.8 0.57 10.1 4.5 2.4 2 1 0 2 2 2 0 YfhG lipoprotein G10 PF01125.17 EMC84887.1 - 3.3 7.5 10.0 0.11 12.2 1.6 2.5 2 1 0 2 2 2 0 G10 protein Baculo_PEP_C PF04513.12 EMC84887.1 - 3.8 7.6 12.0 1.6 8.8 3.8 3.1 2 2 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus MbeB_N PF04837.12 EMC84887.1 - 4.1 7.8 10.0 2.6 8.4 0.9 3.2 2 0 0 2 2 2 0 MbeB-like, N-term conserved region COG2 PF06148.11 EMC84887.1 - 6.5 6.8 19.2 0.62 10.1 6.2 3.2 2 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Fib_alpha PF08702.10 EMC84887.1 - 7.6 6.7 31.4 1.7 8.9 3.4 3.0 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family DUF2894 PF11445.8 EMC84887.1 - 7.7 6.9 12.5 9.9 6.6 2.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2894) SEA PF01390.20 EMC84889.1 - 1.6e-12 47.4 0.1 7.8e-11 42.0 0.5 3.7 3 0 0 3 3 3 1 SEA domain SLS PF14611.6 EMC84889.1 - 0.66 9.8 0.0 0.66 9.8 0.0 2.6 3 1 0 3 3 3 0 Mitochondrial inner-membrane-bound regulator SEA PF01390.20 EMC84891.1 - 1.2e-10 41.4 0.2 1.2e-10 41.4 0.2 2.2 2 0 0 2 2 2 1 SEA domain Latrophilin PF02354.16 EMC84892.1 - 1.7e-23 83.3 2.7 1.7e-23 83.3 2.7 1.0 1 0 0 1 1 1 1 Latrophilin Cytoplasmic C-terminal region Cadherin PF00028.17 EMC84894.1 - 3.2e-114 373.7 4.3 2.1e-22 79.4 0.1 7.5 7 0 0 7 7 7 7 Cadherin domain Protocadherin PF08374.11 EMC84894.1 - 1.5e-85 286.6 3.4 2.4e-85 286.0 3.4 1.3 1 0 0 1 1 1 1 Protocadherin Cadherin_2 PF08266.12 EMC84894.1 - 6.2e-20 70.8 0.1 9.5e-09 35.0 0.0 5.2 5 0 0 5 5 5 3 Cadherin-like Cadherin_3 PF16184.5 EMC84894.1 - 7e-10 38.9 10.4 0.008 16.2 0.1 5.9 5 0 0 5 5 5 4 Cadherin-like Cadherin_4 PF17803.1 EMC84894.1 - 0.0039 17.8 37.9 0.039 14.6 0.6 6.0 7 0 0 7 7 6 3 Bacterial cadherin-like domain Big_9 PF17963.1 EMC84894.1 - 0.012 16.3 28.5 0.98 10.2 1.1 5.5 5 0 0 5 5 5 0 Bacterial Ig domain TMEM154 PF15102.6 EMC84894.1 - 0.012 15.5 0.3 0.035 14.0 0.3 1.8 1 0 0 1 1 1 0 TMEM154 protein family RET_CLD1 PF17756.1 EMC84894.1 - 0.018 15.3 0.0 2.4 8.5 0.0 2.9 2 0 0 2 2 2 0 RET Cadherin like domain 1 AP3D1 PF06375.11 EMC84894.1 - 0.026 14.7 0.9 0.062 13.5 0.9 1.5 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Y_Y_Y PF07495.13 EMC84894.1 - 0.071 13.1 0.0 1.9 8.5 0.0 3.4 3 0 0 3 3 3 0 Y_Y_Y domain EphA2_TM PF14575.6 EMC84894.1 - 0.12 13.3 0.1 0.52 11.2 0.2 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Cadherin_C_2 PF16492.5 EMC84894.1 - 0.12 13.1 0.1 1.2 9.9 0.0 2.5 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal He_PIG PF05345.12 EMC84894.1 - 0.19 12.0 7.3 2.4 8.4 0.0 4.9 5 1 0 5 5 4 0 Putative Ig domain DSPc PF00782.20 EMC84896.1 - 1.9e-08 34.2 0.0 2.6e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC84896.1 - 3.3e-07 30.1 0.0 5.4e-07 29.4 0.0 1.4 1 1 0 1 1 1 1 Protein-tyrosine phosphatase 7tm_1 PF00001.21 EMC84897.1 - 2.8e-30 105.6 34.8 4e-30 105.0 34.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Peptidase_C65 PF10275.9 EMC84899.1 - 8.7e-54 182.6 0.0 1e-53 182.3 0.0 1.0 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.19 EMC84899.1 - 0.00021 21.8 0.0 0.00031 21.3 0.0 1.2 1 0 0 1 1 1 1 OTU-like cysteine protease Sad1_UNC PF07738.13 EMC84901.1 - 3.5e-33 114.4 0.6 7.1e-33 113.4 0.6 1.5 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal RNA_pol_Rpb1_2 PF00623.20 EMC84902.1 - 7.8e-17 62.0 0.0 1.1e-16 61.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 wnt PF00110.19 EMC84903.1 - 1.7e-88 297.2 27.2 2.8e-88 296.5 27.2 1.3 1 1 0 1 1 1 1 wnt family ILEI PF15711.5 EMC84904.1 - 2.6e-28 98.3 0.0 3.9e-28 97.8 0.0 1.3 1 0 0 1 1 1 1 Interleukin-like EMT inducer Y_phosphatase PF00102.27 EMC84905.1 - 2.1e-146 485.7 6.8 2.9e-86 288.9 1.5 2.6 2 0 0 2 2 2 2 Protein-tyrosine phosphatase Carb_anhydrase PF00194.21 EMC84905.1 - 5.8e-74 248.8 0.2 1e-73 248.0 0.2 1.4 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase fn3 PF00041.21 EMC84905.1 - 4.1e-12 46.3 2.4 5.3e-12 45.9 0.1 2.6 3 0 0 3 3 3 1 Fibronectin type III domain DSPc PF00782.20 EMC84905.1 - 0.00066 19.5 1.0 0.02 14.7 0.0 3.5 4 0 0 4 4 4 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC84905.1 - 0.0049 16.9 0.0 0.01 15.8 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EMC84905.1 - 0.061 13.4 0.1 0.3 11.2 0.0 2.2 2 0 0 2 2 2 0 Inositol hexakisphosphate Sacchrp_dh_C PF16653.5 EMC84906.1 - 6e-82 275.7 0.0 1.1e-81 274.8 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain AlaDh_PNT_N PF05222.15 EMC84906.1 - 2.6e-27 95.8 0.9 2.2e-26 92.8 0.0 2.7 3 0 0 3 3 3 1 Alanine dehydrogenase/PNT, N-terminal domain Sacchrp_dh_NADP PF03435.18 EMC84906.1 - 9.1e-24 84.2 0.1 1.7e-23 83.3 0.1 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain AlaDh_PNT_C PF01262.21 EMC84906.1 - 4.3e-08 32.7 0.0 5e-05 22.7 0.0 3.2 2 1 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Shikimate_DH PF01488.20 EMC84906.1 - 0.00042 20.4 0.0 0.00088 19.3 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Semialdhyde_dh PF01118.24 EMC84906.1 - 0.003 18.0 0.1 0.011 16.2 0.1 2.0 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain ThiF PF00899.21 EMC84906.1 - 0.015 14.7 0.3 0.043 13.2 0.1 1.8 1 1 1 2 2 2 0 ThiF family P35 PF02331.15 EMC84906.1 - 0.12 11.7 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Apoptosis preventing protein DUF2325 PF10087.9 EMC84906.1 - 0.14 12.3 0.1 0.5 10.5 0.1 2.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2325) DUF1041 PF06292.17 EMC84907.1 - 2.3e-30 105.1 2.1 7.5e-30 103.4 2.1 2.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1041) PH PF00169.29 EMC84907.1 - 4.8e-09 36.7 0.0 1.2e-08 35.4 0.0 1.7 1 0 0 1 1 1 1 PH domain RVT_1 PF00078.27 EMC84908.1 - 0.025 14.1 0.0 0.052 13.1 0.0 1.6 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Na_sulph_symp PF00939.19 EMC84909.1 - 4.4e-85 286.5 28.6 5.2e-85 286.3 28.6 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 EMC84909.1 - 1.1e-23 83.9 15.1 6.8e-14 51.8 1.2 3.1 2 1 1 3 3 3 3 Citrate transporter ATP-synt_S1 PF05827.12 EMC84910.1 - 2.6e-53 179.8 0.1 4.3e-53 179.1 0.1 1.4 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) IQ PF00612.27 EMC84911.1 - 0.022 14.5 0.4 0.055 13.3 0.4 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif ETC_C1_NDUFA5 PF04716.14 EMC84912.1 - 8.4e-26 89.6 0.3 1.1e-25 89.2 0.3 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region NEL PF14496.6 EMC84912.1 - 0.025 14.0 0.1 1.1 8.6 0.1 2.1 1 1 0 2 2 2 0 C-terminal novel E3 ligase, LRR-interacting Ank_2 PF12796.7 EMC84913.1 - 2.2e-79 262.1 20.7 6.2e-11 42.7 0.0 6.3 1 1 8 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC84913.1 - 5.4e-44 148.0 2.4 8.6e-09 35.8 0.0 8.2 7 2 2 9 9 9 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC84913.1 - 2.2e-37 122.8 5.9 0.0013 19.0 0.2 11.3 11 0 0 11 11 11 7 Ankyrin repeat Ank_5 PF13857.6 EMC84913.1 - 9.9e-32 108.6 8.4 8e-07 29.2 0.0 9.0 3 2 8 11 11 11 9 Ankyrin repeats (many copies) Ank PF00023.30 EMC84913.1 - 1.1e-25 88.9 11.2 0.044 14.3 0.3 10.5 11 0 0 11 11 11 7 Ankyrin repeat SOCS_box PF07525.16 EMC84913.1 - 6.3e-11 42.4 8.7 5.1e-10 39.6 9.6 2.0 2 0 0 2 2 2 1 SOCS box Pax7 PF12360.8 EMC84913.1 - 0.058 13.6 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Paired box protein 7 WH1 PF00568.23 EMC84914.1 - 4.6e-36 123.1 0.0 6.7e-36 122.6 0.0 1.3 1 0 0 1 1 1 1 WH1 domain PBD PF00786.28 EMC84914.1 - 3.1e-19 69.1 0.5 7.6e-19 67.8 0.1 1.9 2 0 0 2 2 2 1 P21-Rho-binding domain WH2 PF02205.20 EMC84914.1 - 1.3e-16 59.8 1.7 1.6e-07 30.9 0.1 2.6 2 0 0 2 2 2 2 WH2 motif DUF4918 PF16265.5 EMC84914.1 - 0.052 13.1 0.0 0.093 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4918) PQQ PF01011.21 EMC84914.1 - 0.087 12.8 0.0 0.33 10.9 0.0 2.0 1 0 0 1 1 1 0 PQQ enzyme repeat Glyco_hydro_56 PF01630.18 EMC84915.1 - 5.2e-148 492.5 0.8 6.2e-148 492.3 0.8 1.0 1 0 0 1 1 1 1 Hyaluronidase EGF PF00008.27 EMC84915.1 - 0.0073 16.6 2.6 0.19 12.1 0.0 2.5 2 0 0 2 2 2 1 EGF-like domain EGF_2 PF07974.13 EMC84915.1 - 0.28 11.6 7.6 0.48 10.8 0.7 2.5 2 0 0 2 2 2 0 EGF-like domain Usg PF06233.12 EMC84916.1 - 0.21 11.7 1.0 0.6 10.3 1.0 1.8 1 0 0 1 1 1 0 Usg-like family LIM PF00412.22 EMC84917.1 - 1.5e-62 207.7 63.3 1.7e-14 53.8 3.0 5.1 5 0 0 5 5 5 5 LIM domain zf-RRN7 PF11781.8 EMC84917.1 - 0.29 10.9 0.1 0.29 10.9 0.1 9.2 10 1 0 10 10 10 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Ran_BP1 PF00638.18 EMC84918.1 - 2e-191 625.4 19.9 6.5e-55 184.6 0.5 4.9 5 0 0 5 5 4 4 RanBP1 domain IR1-M PF12185.8 EMC84918.1 - 7.3e-41 137.9 5.8 2.1e-24 85.2 0.1 2.8 2 0 0 2 2 2 2 Nup358/RanBP2 E3 ligase domain Pro_isomerase PF00160.21 EMC84918.1 - 2.3e-39 135.2 0.7 2.3e-39 135.2 0.7 2.0 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-RanBP PF00641.18 EMC84918.1 - 1.9e-20 71.9 32.2 1.3e-08 33.9 4.3 3.5 3 0 0 3 3 3 3 Zn-finger in Ran binding protein and others WH1 PF00568.23 EMC84918.1 - 2.9e-17 62.6 7.4 0.00039 20.3 0.2 4.6 4 0 0 4 4 4 4 WH1 domain TPR_1 PF00515.28 EMC84918.1 - 3e-05 23.6 2.4 0.0017 18.1 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EMC84918.1 - 4.3e-05 23.3 3.0 0.00053 19.9 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EMC84918.1 - 0.0041 17.2 3.5 0.41 11.0 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EMC84918.1 - 0.007 17.1 0.0 0.12 13.3 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EMC84918.1 - 0.0083 16.8 0.3 0.062 14.0 0.0 2.7 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EMC84918.1 - 0.045 14.3 1.2 28 5.3 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat AMIN PF11741.8 EMC84918.1 - 0.067 13.3 1.3 22 5.3 0.0 4.1 4 0 0 4 4 4 0 AMIN domain Atg14 PF10186.9 EMC84919.1 - 0.00063 18.9 15.9 0.00081 18.6 15.9 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 bZIP_1 PF00170.21 EMC84919.1 - 0.0007 19.6 2.8 0.0007 19.6 2.8 3.4 2 1 2 4 4 4 1 bZIP transcription factor NPV_P10 PF05531.12 EMC84919.1 - 0.0023 18.3 7.2 0.0027 18.1 1.0 2.8 2 1 1 3 3 2 1 Nucleopolyhedrovirus P10 protein DHR10 PF18595.1 EMC84919.1 - 0.0033 17.5 13.4 0.0033 17.5 13.4 2.2 1 1 1 2 2 2 1 Designed helical repeat protein 10 domain Spc42p PF11544.8 EMC84919.1 - 0.0043 17.0 6.4 0.0043 17.0 6.4 2.4 2 1 0 2 2 2 1 Spindle pole body component Spc42p HALZ PF02183.18 EMC84919.1 - 0.013 15.7 1.3 0.013 15.7 1.3 3.5 3 1 1 4 4 4 0 Homeobox associated leucine zipper RVT_connect PF06815.13 EMC84919.1 - 0.05 13.9 2.8 0.31 11.3 0.1 2.6 1 1 0 2 2 2 0 Reverse transcriptase connection domain RACo_linker PF17650.1 EMC84919.1 - 0.052 13.4 1.1 0.18 11.7 0.3 2.0 1 1 1 2 2 2 0 RACo linker region FapA PF03961.13 EMC84919.1 - 0.065 11.8 11.3 0.083 11.5 11.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DASH_Dam1 PF08653.10 EMC84919.1 - 0.12 12.2 2.4 0.31 10.9 0.3 2.5 2 1 1 3 3 3 0 DASH complex subunit Dam1 DUF1322 PF07032.11 EMC84919.1 - 0.14 12.7 0.8 0.67 10.5 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1322) DASH_Dad1 PF08649.10 EMC84919.1 - 0.14 12.4 3.2 0.25 11.5 0.4 2.5 1 1 1 2 2 2 0 DASH complex subunit Dad1 Rootletin PF15035.6 EMC84919.1 - 0.21 11.6 19.4 0.38 10.7 19.2 1.5 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF1664 PF07889.12 EMC84919.1 - 0.34 10.9 7.7 0.15 12.1 4.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Lipase_chap PF03280.14 EMC84919.1 - 0.45 10.4 12.8 0.73 9.8 12.8 1.2 1 0 0 1 1 1 0 Proteobacterial lipase chaperone protein Baculo_PEP_C PF04513.12 EMC84919.1 - 0.51 10.4 4.2 0.58 10.2 3.0 1.8 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus V_ATPase_I PF01496.19 EMC84919.1 - 0.52 8.2 11.4 0.66 7.8 11.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF87 PF01935.17 EMC84919.1 - 0.58 10.2 7.5 0.3 11.1 5.1 1.7 1 1 1 2 2 2 0 Helicase HerA, central domain Ntox28 PF15605.6 EMC84919.1 - 0.75 10.1 9.4 2.6 8.3 3.9 2.3 1 1 1 2 2 2 0 Bacterial toxin 28 FUSC PF04632.12 EMC84919.1 - 0.8 8.2 2.6 1.1 7.7 2.6 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Phage_GPO PF05929.11 EMC84919.1 - 1 8.9 10.2 1.4 8.5 10.2 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase TMPIT PF07851.13 EMC84919.1 - 1.7 7.8 15.8 0.049 12.9 6.8 2.0 1 1 1 2 2 2 0 TMPIT-like protein DUF3450 PF11932.8 EMC84919.1 - 3 7.1 18.8 0.05 12.9 7.0 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) TMF_TATA_bd PF12325.8 EMC84919.1 - 3.2 8.0 18.5 0.079 13.2 10.1 2.3 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding CorA PF01544.18 EMC84919.1 - 3.3 6.9 10.8 6.9 5.9 8.8 2.2 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein GvpL_GvpF PF06386.11 EMC84919.1 - 4.2 7.2 9.8 2.7 7.8 8.0 1.5 1 1 1 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF CENP-F_leu_zip PF10473.9 EMC84919.1 - 5.9 6.9 22.6 0.41 10.7 10.2 2.9 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CREPT PF16566.5 EMC84919.1 - 6.7 6.9 18.6 5.8 7.1 7.8 3.1 1 1 2 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour GIT_CC PF16559.5 EMC84919.1 - 9.1 6.2 11.4 0.22 11.4 0.7 2.7 2 1 1 3 3 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor ATG11 PF10377.9 EMC84919.1 - 9.1 6.4 10.1 3.3 7.8 1.1 3.1 1 1 2 3 3 3 0 Autophagy-related protein 11 NiFe-hyd_HybE PF11939.8 EMC84920.1 - 0.064 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 [NiFe]-hydrogenase assembly, chaperone, HybE SID-1_RNA_chan PF13965.6 EMC84921.1 - 0.042 12.3 0.3 0.056 11.9 0.3 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CLN3 PF02487.17 EMC84921.1 - 0.084 11.9 0.5 0.12 11.4 0.5 1.1 1 0 0 1 1 1 0 CLN3 protein KI67R PF08065.12 EMC84921.1 - 1.1 9.9 5.3 0.7 10.5 2.5 2.0 2 0 0 2 2 2 0 KI67R (NUC007) repeat OAD_gamma PF04277.13 EMC84921.1 - 1.1 9.9 9.7 18 6.0 9.7 2.2 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain TNFR_c6 PF00020.18 EMC84921.1 - 1.8 9.0 23.2 0.065 13.6 8.4 3.7 1 1 2 4 4 4 0 TNFR/NGFR cysteine-rich region Nop14 PF04147.12 EMC84922.1 - 0.0069 14.7 39.1 0.0079 14.5 39.1 1.0 1 0 0 1 1 1 1 Nop14-like family Mpp10 PF04006.12 EMC84922.1 - 0.0079 14.7 46.2 0.0092 14.5 46.2 1.0 1 0 0 1 1 1 1 Mpp10 protein SAPS PF04499.15 EMC84922.1 - 0.023 13.5 20.9 0.024 13.4 20.9 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Zip PF02535.22 EMC84922.1 - 0.059 12.6 18.5 0.072 12.3 18.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 EMC84922.1 - 0.14 10.9 31.4 0.16 10.7 31.4 1.1 1 0 0 1 1 1 0 Presenilin Hydin_ADK PF17213.3 EMC84922.1 - 0.19 12.0 18.3 0.23 11.7 18.3 1.0 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Orf78 PF06024.12 EMC84922.1 - 0.22 11.9 17.6 7.8e+02 0.4 17.6 2.4 1 1 0 1 1 1 0 Orf78 (ac78) Raftlin PF15250.6 EMC84922.1 - 0.25 10.1 21.9 0.28 9.9 21.9 1.0 1 0 0 1 1 1 0 Raftlin LAP1C PF05609.12 EMC84922.1 - 0.28 10.2 19.8 0.33 10.0 19.8 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Neur_chan_memb PF02932.16 EMC84922.1 - 0.3 11.1 16.2 0.33 11.0 16.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region NPR3 PF03666.13 EMC84922.1 - 0.41 9.4 35.3 0.48 9.2 35.3 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF262 PF03235.14 EMC84922.1 - 0.44 10.7 19.1 0.5 10.5 19.1 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 PA26 PF04636.13 EMC84922.1 - 0.62 8.9 21.0 0.73 8.7 21.0 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) HCO3_cotransp PF00955.21 EMC84922.1 - 1.1 8.0 6.6 1.3 7.8 6.6 1.2 1 0 0 1 1 1 0 HCO3- transporter family Suf PF05843.14 EMC84922.1 - 1.2 9.1 18.4 1.5 8.8 18.4 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) ALMT PF11744.8 EMC84922.1 - 1.3 7.8 22.6 1.5 7.6 22.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM60A PF15396.6 EMC84922.1 - 1.5 8.8 30.2 1.9 8.4 30.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Menin PF05053.13 EMC84922.1 - 1.6 7.0 13.5 1.8 6.8 13.5 1.1 1 0 0 1 1 1 0 Menin AAA_11 PF13086.6 EMC84922.1 - 1.6 8.4 30.8 2.1 8.1 30.8 1.2 1 0 0 1 1 1 0 AAA domain Membralin PF09746.9 EMC84922.1 - 1.7 7.6 16.6 2 7.4 16.6 1.1 1 0 0 1 1 1 0 Tumour-associated protein SLC12 PF03522.15 EMC84922.1 - 1.8 7.5 31.0 2.2 7.2 31.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 SID-1_RNA_chan PF13965.6 EMC84922.1 - 1.9 6.8 12.6 2.1 6.6 12.6 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Caldesmon PF02029.15 EMC84922.1 - 2.1 7.0 54.4 2.5 6.7 54.4 1.1 1 0 0 1 1 1 0 Caldesmon CCSAP PF15748.5 EMC84922.1 - 2.7 8.1 41.5 3.2 7.8 41.5 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Endostatin PF06482.11 EMC84922.1 - 2.7 7.4 15.6 3.6 7.0 15.6 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Rrn6 PF10214.9 EMC84922.1 - 2.9 6.3 18.4 3.5 6.0 18.4 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor CDC27 PF09507.10 EMC84922.1 - 4.3 6.6 59.5 5 6.4 59.5 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF5427 PF10310.9 EMC84922.1 - 5 6.0 38.6 6.2 5.7 38.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Velvet PF11754.8 EMC84922.1 - 6.6 6.6 10.2 9.3 6.1 10.2 1.3 1 0 0 1 1 1 0 Velvet factor Med12-LCEWAV PF12145.8 EMC84922.1 - 6.9 5.4 16.3 8.7 5.1 16.3 1.1 1 0 0 1 1 1 0 Eukaryotic Mediator 12 subunit domain DUF4045 PF13254.6 EMC84922.1 - 8.2 5.9 37.1 9.9 5.7 37.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) MCM_bind PF09739.9 EMC84922.1 - 9.1 4.6 29.3 11 4.3 29.3 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Septin PF00735.18 EMC84923.1 - 6.6e-94 314.3 2.1 7.7e-94 314.1 2.1 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EMC84923.1 - 0.00016 21.8 0.0 0.00034 20.7 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC84923.1 - 0.00034 20.2 1.3 0.17 11.4 0.1 2.4 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain G-alpha PF00503.20 EMC84923.1 - 0.00052 19.3 4.1 0.059 12.5 0.1 2.9 2 1 0 3 3 3 2 G-protein alpha subunit AAA_22 PF13401.6 EMC84923.1 - 0.0018 18.6 0.1 0.0032 17.7 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EMC84923.1 - 0.0024 18.3 0.0 0.0038 17.6 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain Microtub_bd PF16796.5 EMC84923.1 - 0.0044 17.0 0.1 0.017 15.1 0.0 2.0 2 1 0 2 2 2 1 Microtubule binding AAA_29 PF13555.6 EMC84923.1 - 0.0047 16.6 0.1 0.0093 15.7 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain Roc PF08477.13 EMC84923.1 - 0.0051 17.0 0.0 0.012 15.8 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EMC84923.1 - 0.0053 16.7 0.3 0.48 10.3 0.0 2.8 2 1 1 3 3 3 1 RsgA GTPase AAA_7 PF12775.7 EMC84923.1 - 0.0079 15.7 0.0 0.017 14.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region Ras PF00071.22 EMC84923.1 - 0.016 14.8 0.1 0.14 11.8 0.0 2.3 2 0 0 2 2 2 0 Ras family ABC_tran PF00005.27 EMC84923.1 - 0.032 14.7 0.5 0.049 14.2 0.4 1.6 1 1 0 1 1 1 0 ABC transporter RHD3 PF05879.12 EMC84923.1 - 0.038 12.1 0.6 0.16 10.0 0.1 1.9 2 0 0 2 2 2 0 Root hair defective 3 GTP-binding protein (RHD3) DUF87 PF01935.17 EMC84923.1 - 0.073 13.2 0.1 0.31 11.1 0.0 1.9 2 0 0 2 2 2 0 Helicase HerA, central domain T2SSE PF00437.20 EMC84923.1 - 0.088 11.9 0.0 0.19 10.7 0.0 1.5 2 0 0 2 2 2 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 EMC84923.1 - 0.15 11.4 0.0 0.3 10.4 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Smg4_UPF3 PF03467.15 EMC84924.1 - 3.6e-49 167.1 0.1 3.6e-49 167.1 0.1 3.2 2 1 0 2 2 2 1 Smg-4/UPF3 family FerI PF08151.12 EMC84924.1 - 0.22 11.7 3.5 0.73 10.0 3.5 1.9 1 0 0 1 1 1 0 FerI (NUC094) domain DUF3142 PF11340.8 EMC84926.1 - 0.23 11.3 2.7 64 3.3 0.0 4.6 3 3 1 5 5 5 0 Protein of unknown function (DUF3142) FAST_1 PF06743.15 EMC84927.1 - 9.4e-19 67.1 1.1 1.4e-18 66.6 1.1 1.3 1 0 0 1 1 1 1 FAST kinase-like protein, subdomain 1 RAP PF08373.10 EMC84927.1 - 9.4e-06 25.6 0.0 1.6e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 RAP domain FAST_2 PF08368.12 EMC84927.1 - 2.1e-05 25.2 0.0 8.1e-05 23.3 0.0 1.8 2 0 0 2 2 2 1 FAST kinase-like protein, subdomain 2 Cyclin PF08613.11 EMC84928.1 - 0.46 10.8 3.0 0.6 10.5 3.0 1.2 1 0 0 1 1 1 0 Cyclin TMEM214 PF10151.9 EMC84929.1 - 1.1e-45 156.4 0.0 1.2e-45 156.3 0.0 1.0 1 0 0 1 1 1 1 TMEM214, C-terminal, caspase 4 activator zf-H2C2_2 PF13465.6 EMC84930.1 - 4.1e-29 99.7 36.9 2.5e-10 40.3 1.7 5.1 5 0 0 5 5 5 4 Zinc-finger double domain zf-H2C2_5 PF13909.6 EMC84930.1 - 2.5e-22 78.3 28.2 8.6e-06 25.4 4.0 4.1 4 0 0 4 4 4 4 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 EMC84930.1 - 2.4e-17 62.3 31.1 0.00018 21.8 0.5 4.1 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC84930.1 - 8.6e-08 32.4 27.5 0.0066 17.2 3.9 4.3 4 0 0 4 4 4 4 C2H2-type zinc finger GAGA PF09237.11 EMC84930.1 - 5.9e-05 22.8 10.5 0.0044 16.8 1.3 3.5 1 1 3 4 4 4 2 GAGA factor zf-C2HE PF16278.5 EMC84930.1 - 0.0019 18.6 21.0 0.67 10.4 1.0 4.1 1 1 3 4 4 4 3 C2HE / C2H2 / C2HC zinc-binding finger Zn_Tnp_IS1595 PF12760.7 EMC84930.1 - 0.75 9.8 16.8 1.4 9.0 1.9 3.2 1 1 2 3 3 3 0 Transposase zinc-ribbon domain zf_C2H2_ZHX PF18387.1 EMC84930.1 - 1 9.1 18.9 0.46 10.2 1.4 3.8 1 1 3 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain OrsD PF12013.8 EMC84930.1 - 1.5 9.3 21.0 7.5 7.0 0.2 4.0 2 1 2 4 4 4 0 Orsellinic acid/F9775 biosynthesis cluster protein D Fer4_21 PF14697.6 EMC84930.1 - 1.6 9.0 8.2 0.74 10.0 0.3 2.6 2 1 0 2 2 2 0 4Fe-4S dicluster domain zf-C2H2_2 PF12756.7 EMC84930.1 - 4.1 7.8 19.8 1.7 9.0 1.0 3.7 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) PP2C PF00481.21 EMC84931.1 - 2e-67 227.5 0.5 1.8e-55 188.4 0.4 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 EMC84931.1 - 0.0032 17.1 0.0 0.016 14.8 0.0 2.2 2 1 0 2 2 2 1 Protein phosphatase 2C Pkinase_Tyr PF07714.17 EMC84932.1 - 9.8e-25 87.3 0.6 2.2e-24 86.2 0.6 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC84932.1 - 1.5e-24 86.8 2.1 4.1e-24 85.3 2.1 1.7 1 1 0 1 1 1 1 Protein kinase domain OSR1_C PF12202.8 EMC84932.1 - 0.095 12.9 0.1 0.37 11.1 0.0 2.0 2 0 0 2 2 2 0 Oxidative-stress-responsive kinase 1 C-terminal domain PRESAN PF09687.10 EMC84932.1 - 0.11 13.0 7.8 0.41 11.2 7.3 2.2 2 0 0 2 2 2 0 Plasmodium RESA N-terminal BCLP PF12304.8 EMC84933.1 - 6e-21 74.8 0.2 6.1e-21 74.8 0.2 1.0 1 0 0 1 1 1 1 Beta-casein like protein GDP_Man_Dehyd PF16363.5 EMC84934.1 - 0.076 12.4 0.0 0.23 10.8 0.0 1.7 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase TPR_14 PF13428.6 EMC84934.1 - 0.12 13.2 13.7 22 6.2 0.1 6.3 5 1 1 6 6 6 0 Tetratricopeptide repeat PPR PF01535.20 EMC84934.1 - 0.16 12.3 1.2 1.2e+02 3.3 0.1 4.5 5 0 0 5 5 5 0 PPR repeat Clathrin PF00637.20 EMC84934.1 - 0.23 11.3 7.7 6 6.7 0.1 4.2 3 2 1 4 4 4 0 Region in Clathrin and VPS TPR_7 PF13176.6 EMC84934.1 - 1 9.5 10.4 34 4.8 0.0 5.5 5 1 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC84934.1 - 5 7.4 10.7 18 5.6 1.6 4.3 3 2 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 EMC84934.1 - 5.1 7.1 12.5 19 5.3 0.4 5.4 4 1 1 5 5 5 0 Tetratricopeptide repeat PID PF00640.23 EMC84935.1 - 2.2e-19 69.9 0.2 2.8e-19 69.5 0.2 1.1 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PID_2 PF14719.6 EMC84935.1 - 1.3e-13 51.2 0.2 1.6e-13 51.0 0.2 1.0 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 EMC84935.1 - 1.2e-10 41.6 0.1 1.6e-10 41.2 0.1 1.1 1 0 0 1 1 1 1 Phosphotyrosine-binding domain fn3 PF00041.21 EMC84936.1 - 2.9e-10 40.3 1.0 4.4e-10 39.8 0.1 1.8 2 0 0 2 2 2 1 Fibronectin type III domain DUF4808 PF16066.5 EMC84936.1 - 0.00017 22.1 0.0 0.00034 21.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4808) Pur_ac_phosph_N PF16656.5 EMC84936.1 - 0.0035 17.9 0.2 0.011 16.3 0.2 1.9 1 1 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain DUF4992 PF16383.5 EMC84936.1 - 0.016 14.7 0.0 0.03 13.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function zf-C2H2_4 PF13894.6 EMC84937.1 - 1.6e-09 37.7 37.7 0.017 15.9 3.5 6.5 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC84937.1 - 1.6e-08 34.5 30.3 0.0014 19.0 3.5 6.4 6 0 0 6 6 6 3 Zinc finger, C2H2 type zf-BED PF02892.15 EMC84937.1 - 1.6e-06 28.0 27.0 0.023 14.7 4.1 5.5 4 1 1 5 5 5 4 BED zinc finger IBR PF01485.21 EMC84937.1 - 9e-06 25.8 16.4 0.088 13.0 1.6 3.5 3 0 0 3 3 3 3 IBR domain, a half RING-finger domain CpXC PF14353.6 EMC84937.1 - 1.3e-05 25.2 9.9 0.018 15.1 0.1 3.7 3 1 0 3 3 3 2 CpXC protein zf-C2H2_jaz PF12171.8 EMC84937.1 - 1.7e-05 24.9 17.4 0.0015 18.8 1.2 4.0 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-FCS PF06467.14 EMC84937.1 - 0.00029 20.7 3.2 0.075 13.0 0.1 3.3 3 0 0 3 3 3 2 MYM-type Zinc finger with FCS sequence motif zf-Di19 PF05605.12 EMC84937.1 - 0.0023 18.2 12.8 1.2 9.5 0.4 4.4 4 0 0 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 EMC84937.1 - 0.0048 17.2 21.5 0.26 11.6 0.2 4.6 3 2 1 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 EMC84937.1 - 0.0067 17.1 9.0 0.46 11.2 0.0 3.7 4 0 0 4 4 3 1 Zinc finger C2H2-type, 3 repeats zf-C2H2_aberr PF17017.5 EMC84937.1 - 0.0084 16.3 21.5 0.14 12.3 0.6 4.4 3 1 1 4 4 4 3 Aberrant zinc-finger zf-C2HE PF16278.5 EMC84937.1 - 0.057 13.9 25.1 2.5 8.6 2.3 6.2 5 2 1 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger zf_PR_Knuckle PF18445.1 EMC84937.1 - 0.12 12.2 0.5 2.7 7.9 0.1 2.9 2 1 0 2 2 2 0 PR zinc knuckle motif Evr1_Alr PF04777.13 EMC84937.1 - 0.2 12.1 6.9 10 6.7 0.7 3.4 2 1 0 3 3 3 0 Erv1 / Alr family zf-C2H2_12 PF18658.1 EMC84937.1 - 1.2 8.8 11.2 9.5 5.9 0.0 3.7 3 1 1 4 4 4 0 Zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 EMC84937.1 - 1.2 9.3 16.5 11 6.2 0.1 5.0 5 0 0 5 5 5 0 Zinc ribbon domain DUF629 PF04780.12 EMC84937.1 - 2.6 6.5 12.9 2.8 6.4 1.0 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF629) DZR PF12773.7 EMC84937.1 - 8.1 6.6 14.4 1.7 8.7 3.0 3.3 3 1 0 3 3 3 0 Double zinc ribbon ATP_bind_1 PF03029.17 EMC84938.1 - 2.3e-56 191.3 0.1 1.2e-55 189.0 0.0 1.8 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein FeoB_N PF02421.18 EMC84938.1 - 0.00053 19.6 0.0 0.001 18.6 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 EMC84938.1 - 0.0054 16.8 0.0 0.011 15.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC84938.1 - 0.012 15.1 0.0 0.026 14.1 0.0 1.7 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Glyco_transf_49 PF13896.6 EMC84939.1 - 1.9e-58 198.4 4.3 1.4e-45 156.1 3.0 2.3 1 1 1 2 2 2 2 Glycosyl-transferase for dystroglycan Glyco_transf_8 PF01501.20 EMC84939.1 - 3e-19 69.6 0.6 5.3e-19 68.8 0.6 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 EMC84939.1 - 7.6e-07 28.8 3.5 1.3e-06 28.1 3.5 1.4 1 0 0 1 1 1 1 Glucosyltransferase 24 WD40_alt PF14077.6 EMC84939.1 - 1.1 9.2 5.8 0.35 10.8 1.8 2.3 2 0 0 2 2 2 0 Alternative WD40 repeat motif Synapsin PF02078.16 EMC84940.1 - 5e-44 148.7 0.0 8.2e-44 148.0 0.0 1.3 1 0 0 1 1 1 1 Synapsin, N-terminal domain Synapsin_C PF02750.14 EMC84940.1 - 9.2e-24 84.1 1.0 1.5e-23 83.4 1.0 1.4 1 0 0 1 1 1 1 Synapsin, ATP binding domain Synapsin_N PF10581.9 EMC84940.1 - 9.6e-20 70.2 4.3 2.1e-19 69.1 4.3 1.6 1 0 0 1 1 1 1 Synapsin N-terminal TIMP PF00965.17 EMC84941.1 - 7.4e-64 214.9 9.8 9.2e-64 214.6 9.8 1.1 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase Synapsin_C PF02750.14 EMC84942.1 - 6.9e-87 290.2 1.6 8.4e-87 290.0 1.6 1.1 1 0 0 1 1 1 1 Synapsin, ATP binding domain Hamartin PF04388.12 EMC84942.1 - 7.2 5.1 14.1 8.3 4.9 14.1 1.1 1 0 0 1 1 1 0 Hamartin protein F-box-like PF12937.7 EMC84943.1 - 7.9e-11 41.7 2.8 1.9e-10 40.5 2.8 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMC84943.1 - 2.3e-05 24.1 1.4 4.7e-05 23.1 1.4 1.6 1 0 0 1 1 1 1 F-box domain PI31_Prot_N PF11566.8 EMC84943.1 - 3.8e-05 23.6 0.1 0.00015 21.6 0.0 2.1 2 1 0 2 2 2 1 PI31 proteasome regulator N-terminal F-box_4 PF15966.5 EMC84943.1 - 0.046 13.6 0.1 0.075 12.9 0.1 1.3 1 0 0 1 1 1 0 F-box Elongin_A PF06881.11 EMC84943.1 - 0.059 13.9 0.2 0.13 12.8 0.2 1.5 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A LBP_BPI_CETP_C PF02886.17 EMC84944.1 - 2.3e-40 138.6 0.2 3.8e-40 137.8 0.2 1.3 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 EMC84944.1 - 1.2e-21 77.0 0.1 3.3e-21 75.6 0.0 1.7 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain HLH PF00010.26 EMC84945.1 - 8.1e-18 64.1 2.2 1.4e-17 63.4 2.2 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain zf_PR_Knuckle PF18445.1 EMC84946.1 - 8.5e-28 95.9 3.6 8.5e-28 95.9 3.6 3.8 3 0 0 3 3 3 1 PR zinc knuckle motif zf-H2C2_2 PF13465.6 EMC84946.1 - 5.1e-23 80.4 58.5 1e-06 28.9 0.6 8.3 9 0 0 9 9 8 6 Zinc-finger double domain zf-C2H2 PF00096.26 EMC84946.1 - 2.8e-18 65.3 62.3 8.2e-05 22.9 2.2 8.5 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC84946.1 - 3.2e-16 58.6 63.1 0.00094 19.8 1.6 8.8 9 0 0 9 9 8 7 C2H2-type zinc finger zf-H2C2_5 PF13909.6 EMC84946.1 - 0.0033 17.1 1.2 0.0033 17.1 1.2 6.4 6 1 0 6 6 5 3 C2H2-type zinc-finger domain zf-met PF12874.7 EMC84946.1 - 0.0036 17.6 43.4 0.0044 17.4 0.8 7.5 7 0 0 7 7 7 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMC84946.1 - 0.0096 16.2 50.5 0.027 14.7 0.2 7.7 7 1 1 8 8 8 4 Zinc-finger double-stranded RNA-binding Mu-like_Com PF10122.9 EMC84946.1 - 0.068 12.6 6.8 0.13 11.8 3.1 2.7 2 1 0 2 2 2 0 Mu-like prophage protein Com SET PF00856.28 EMC84946.1 - 0.07 13.5 0.2 0.18 12.2 0.0 1.8 2 0 0 2 2 2 0 SET domain zf-C2H2_6 PF13912.6 EMC84946.1 - 0.66 10.0 40.3 0.11 12.5 0.9 7.6 7 0 0 7 7 7 0 C2H2-type zinc finger TRAF6_Z2 PF18048.1 EMC84946.1 - 5.6 7.1 9.4 8.5 6.6 0.5 3.8 3 0 0 3 3 3 0 TNF receptor-associated factor 6 zinc finger 2 WD40 PF00400.32 EMC84947.1 - 9.6e-09 35.8 13.0 0.00036 21.3 0.2 5.5 6 1 1 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC84947.1 - 0.00034 20.8 0.4 0.0013 19.0 0.4 2.0 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain BTB PF00651.31 EMC84948.1 - 8e-24 84.0 0.5 4.8e-22 78.3 0.2 3.3 2 1 1 3 3 3 1 BTB/POZ domain Ank_2 PF12796.7 EMC84948.1 - 5.9e-20 71.6 0.0 1.3e-09 38.5 0.0 4.3 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC84948.1 - 7.8e-19 65.8 0.1 1.7e-05 24.8 0.0 5.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 EMC84948.1 - 5.2e-17 62.0 0.0 0.00038 20.9 0.0 4.1 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EMC84948.1 - 1.2e-15 57.2 0.3 1.2e-06 28.7 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EMC84948.1 - 1.2e-14 54.1 0.1 0.0072 16.6 0.0 4.6 4 0 0 4 4 4 4 Ankyrin repeats (many copies) BACK PF07707.15 EMC84948.1 - 0.0017 18.4 0.9 0.0066 16.5 0.1 2.4 2 0 0 2 2 2 1 BTB And C-terminal Kelch FAD_binding_7 PF03441.14 EMC84949.1 - 1.3e-79 266.4 0.3 2.2e-79 265.6 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 EMC84949.1 - 5.6e-26 91.5 0.0 1.1e-25 90.6 0.0 1.4 1 0 0 1 1 1 1 DNA photolyase mTERF PF02536.14 EMC84950.1 - 1.2e-25 90.1 6.7 1.5e-25 89.8 6.7 1.1 1 0 0 1 1 1 1 mTERF XPC-binding PF09280.11 EMC84950.1 - 0.0063 16.2 0.6 0.68 9.7 0.0 3.6 4 0 0 4 4 4 1 XPC-binding domain K-box PF01486.17 EMC84950.1 - 0.043 14.0 0.1 6.2 7.1 0.0 3.2 3 0 0 3 3 3 0 K-box region MarR_2 PF12802.7 EMC84950.1 - 0.15 12.0 0.0 7.8 6.5 0.0 2.4 2 0 0 2 2 2 0 MarR family RRF_GI PF12614.8 EMC84950.1 - 0.18 12.0 1.9 0.33 11.1 0.4 2.2 2 1 1 3 3 3 0 Ribosome recycling factor UPF0444 PF15475.6 EMC84951.1 - 1.6e-45 153.3 14.6 1.8e-45 153.1 14.6 1.0 1 0 0 1 1 1 1 Transmembrane protein C12orf23, UPF0444 Ric8 PF10165.9 EMC84952.1 - 3.7e-131 438.4 2.9 4.2e-131 438.2 2.9 1.0 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn Rif1_N PF12231.8 EMC84952.1 - 0.0062 15.6 0.2 0.013 14.6 0.2 1.5 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal RFX_DNA_binding PF02257.15 EMC84953.1 - 1.4e-34 118.5 0.0 4.4e-34 116.9 0.0 1.9 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.16 EMC84953.1 - 5.8e-05 23.5 0.0 0.00016 22.1 0.0 1.7 1 0 0 1 1 1 1 Poxvirus D5 protein-like RNA_pol_Rpb2_6 PF00562.28 EMC84954.1 - 2.8e-128 428.3 0.0 9.3e-128 426.6 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EMC84954.1 - 1.3e-54 184.8 0.7 2.2e-54 184.1 0.7 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 EMC84954.1 - 5.9e-35 119.5 0.7 1.7e-34 118.1 0.2 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 EMC84954.1 - 7.1e-28 97.5 1.6 8.1e-28 97.3 0.5 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 EMC84954.1 - 5.2e-27 93.9 1.1 1.4e-26 92.5 1.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 EMC84954.1 - 3.6e-21 75.1 0.0 9.1e-21 73.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EMC84954.1 - 1.7e-09 38.1 2.8 1.7e-09 38.1 2.8 2.5 3 0 0 3 3 3 1 RNA polymerase Rpb2, domain 5 Fib_alpha PF08702.10 EMC84956.1 - 1.1e-06 28.9 40.6 0.0076 16.4 2.6 5.3 1 1 4 5 5 5 3 Fibrinogen alpha/beta chain family Spc7 PF08317.11 EMC84956.1 - 1e-05 24.6 47.5 0.024 13.5 10.9 4.7 1 1 4 5 5 5 4 Spc7 kinetochore protein Tropomyosin_1 PF12718.7 EMC84956.1 - 3.8e-05 23.9 12.4 3.8e-05 23.9 12.4 4.8 2 2 2 4 4 4 1 Tropomyosin like Baculo_PEP_C PF04513.12 EMC84956.1 - 9.3e-05 22.5 31.2 0.051 13.6 3.2 5.1 1 1 4 5 5 5 3 Baculovirus polyhedron envelope protein, PEP, C terminus TPR_MLP1_2 PF07926.12 EMC84956.1 - 0.00012 22.1 37.6 0.003 17.6 1.5 4.8 2 2 3 5 5 5 2 TPR/MLP1/MLP2-like protein Tropomyosin PF00261.20 EMC84956.1 - 0.0003 20.2 41.2 0.0054 16.1 2.2 5.2 2 1 3 5 5 5 2 Tropomyosin EzrA PF06160.12 EMC84956.1 - 0.003 15.8 41.5 0.028 12.6 25.8 4.0 1 1 1 2 2 2 1 Septation ring formation regulator, EzrA RPW8 PF05659.11 EMC84956.1 - 0.0084 15.8 23.6 0.015 15.0 0.6 5.1 2 1 1 4 4 4 2 Arabidopsis broad-spectrum mildew resistance protein RPW8 Fez1 PF06818.15 EMC84956.1 - 0.017 15.6 37.9 1.5 9.2 0.9 4.0 1 1 3 4 4 4 0 Fez1 DUF1664 PF07889.12 EMC84956.1 - 0.018 15.1 40.8 1.1 9.3 7.4 7.0 1 1 7 8 8 8 0 Protein of unknown function (DUF1664) GAS PF13851.6 EMC84956.1 - 0.02 14.2 42.2 0.35 10.2 17.3 4.6 1 1 3 4 4 4 0 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 EMC84956.1 - 0.032 14.2 50.1 0.043 13.8 0.8 5.6 2 1 3 5 5 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Syntaxin-6_N PF09177.11 EMC84956.1 - 0.12 12.9 36.9 1.3 9.6 4.9 5.5 1 1 2 4 4 4 0 Syntaxin 6, N-terminal DHR10 PF18595.1 EMC84956.1 - 0.16 12.0 40.1 0.27 11.3 8.1 5.8 2 2 3 5 5 4 0 Designed helical repeat protein 10 domain DUF3584 PF12128.8 EMC84956.1 - 0.18 9.3 35.5 0.043 11.4 20.7 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) HMMR_N PF15905.5 EMC84956.1 - 0.28 10.6 48.0 0.2 11.1 1.6 4.3 1 1 3 4 4 4 0 Hyaluronan mediated motility receptor N-terminal FlaC_arch PF05377.11 EMC84956.1 - 0.53 10.7 47.9 0.45 11.0 3.3 9.1 6 2 3 9 9 9 0 Flagella accessory protein C (FlaC) Cob_adeno_trans PF01923.18 EMC84956.1 - 0.68 10.1 16.6 1.7 8.8 0.5 4.8 1 1 2 3 3 3 0 Cobalamin adenosyltransferase YvrJ PF12841.7 EMC84956.1 - 0.88 9.1 15.4 2.4 7.7 0.1 5.6 6 0 0 6 6 6 0 YvrJ protein family E2R135 PF11570.8 EMC84956.1 - 0.97 9.7 12.8 1.2 9.4 1.8 4.0 2 1 2 4 4 4 0 Coiled-coil receptor-binding R-domain of colicin E2 TMPIT PF07851.13 EMC84956.1 - 1.3 8.2 33.4 0.8 8.9 7.1 4.5 1 1 3 5 5 5 0 TMPIT-like protein DUF4172 PF13776.6 EMC84956.1 - 1.6 9.1 6.8 0.5 10.7 0.8 3.3 3 1 1 4 4 2 0 Domain of unknown function (DUF4172) COG2 PF06148.11 EMC84956.1 - 1.8 8.6 35.6 0.17 12.0 0.7 6.4 2 2 5 7 7 7 0 COG (conserved oligomeric Golgi) complex component, COG2 Occludin_ELL PF07303.13 EMC84956.1 - 1.9 9.3 19.4 4.2 8.1 2.8 5.6 2 2 3 6 6 6 0 Occludin homology domain FOXP-CC PF16159.5 EMC84956.1 - 2 9.1 5.3 1.6 9.4 0.6 3.1 3 0 0 3 3 3 0 FOXP coiled-coil domain DUF4200 PF13863.6 EMC84956.1 - 2 8.8 38.7 3.3 8.2 8.2 5.5 2 1 3 5 5 5 0 Domain of unknown function (DUF4200) TPK_catalytic PF04263.16 EMC84956.1 - 3 7.9 12.6 2.9 8.0 0.8 3.3 2 2 2 4 4 4 0 Thiamin pyrophosphokinase, catalytic domain KxDL PF10241.9 EMC84956.1 - 3.2 8.1 34.9 5.1 7.4 0.2 7.3 2 2 4 7 7 7 0 Uncharacterized conserved protein ADIP PF11559.8 EMC84956.1 - 3.7 7.6 39.7 0.029 14.5 4.3 5.6 2 2 4 6 6 6 0 Afadin- and alpha -actinin-Binding DUF5082 PF16888.5 EMC84956.1 - 4 7.7 38.9 3 8.1 1.6 6.4 1 1 5 6 6 6 0 Domain of unknown function (DUF5082) LPP PF04728.13 EMC84956.1 - 4.3 7.8 28.7 4.6 7.7 0.2 7.6 6 2 2 8 8 7 0 Lipoprotein leucine-zipper Laminin_II PF06009.12 EMC84956.1 - 5 7.1 38.8 0.14 12.2 1.6 5.6 1 1 6 7 7 7 0 Laminin Domain II APG6_N PF17675.1 EMC84956.1 - 5.2 7.6 43.5 6 7.4 0.1 4.8 2 1 2 4 4 3 0 Apg6 coiled-coil region PCRF PF03462.18 EMC84956.1 - 5.5 6.8 33.3 3.2 7.6 0.8 4.5 3 1 1 4 4 4 0 PCRF domain DUF745 PF05335.13 EMC84956.1 - 8.2 6.1 28.8 4.8 6.9 4.8 4.5 1 1 5 6 6 6 0 Protein of unknown function (DUF745) Laminin_I PF06008.14 EMC84956.1 - 9.1 5.9 38.2 0.32 10.7 5.8 5.2 1 1 1 4 4 4 0 Laminin Domain I Pkinase_Tyr PF07714.17 EMC84957.1 - 3.8e-38 131.3 0.1 7e-38 130.4 0.1 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase SAM_1 PF00536.30 EMC84957.1 - 3.4e-23 81.9 0.0 4.9e-23 81.3 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC84957.1 - 5.4e-22 77.7 0.0 8.5e-22 77.1 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pkinase PF00069.25 EMC84957.1 - 8.6e-12 45.0 0.0 1.6e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Helicase_C PF00271.31 EMC84960.1 - 0.01 16.2 0.0 4.8 7.6 0.0 2.1 2 0 0 2 2 2 0 Helicase conserved C-terminal domain CarbpepA_inh PF02977.15 EMC84961.1 - 0.0063 16.3 0.0 0.019 14.7 0.0 1.8 1 1 0 1 1 1 1 Carboxypeptidase A inhibitor Chromosome_seg PF13889.6 EMC84962.1 - 2.6e-18 65.9 0.1 7e-18 64.5 0.1 1.8 1 0 0 1 1 1 1 Chromosome segregation during meiosis DUF4210 PF13915.6 EMC84962.1 - 5.7e-14 52.4 0.1 1.4e-13 51.2 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) Band_7 PF01145.25 EMC84963.1 - 2.4e-26 92.8 3.7 2.4e-26 92.8 2.1 1.8 1 1 1 2 2 2 1 SPFH domain / Band 7 family Band_7_C PF16200.5 EMC84963.1 - 8.5e-18 64.2 0.7 8.5e-18 64.2 0.7 2.2 2 0 0 2 2 2 1 C-terminal region of band_7 DUF4769 PF15992.5 EMC84963.1 - 0.02 14.7 0.4 0.029 14.2 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4769) Band_7_1 PF13421.6 EMC84963.1 - 0.076 12.7 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 SPFH domain-Band 7 family Alkyl_sulf_dimr PF14863.6 EMC84963.1 - 2.3 8.7 6.0 4.4 7.8 6.0 1.5 1 0 0 1 1 1 0 Alkyl sulfatase dimerisation TPR_2 PF07719.17 EMC84964.1 - 5.2e-15 54.3 5.1 0.042 14.0 0.0 6.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 EMC84964.1 - 3e-12 45.8 1.9 0.0016 18.2 0.0 5.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMC84964.1 - 1.2e-11 44.9 7.6 0.00022 21.7 0.2 5.7 4 2 1 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.6 EMC84964.1 - 1.2e-07 31.9 11.7 0.0018 18.5 0.1 5.8 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 EMC84964.1 - 1.1e-05 25.8 17.5 0.097 13.5 0.0 7.3 6 2 2 8 8 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMC84964.1 - 1.3e-05 25.0 0.0 9.4 6.7 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 EMC84964.1 - 2.3e-05 25.0 9.5 7.8 7.2 0.4 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC84964.1 - 0.00018 21.7 6.6 2.5 8.4 0.6 4.4 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EMC84964.1 - 0.00056 19.8 6.8 2.6 8.3 0.0 6.4 6 1 0 7 7 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMC84964.1 - 0.00063 19.4 0.1 0.31 10.8 0.1 4.2 4 0 0 4 4 4 1 TPR repeat BTAD PF03704.17 EMC84964.1 - 0.001 19.5 10.5 0.0012 19.3 0.0 4.3 6 0 0 6 6 5 1 Bacterial transcriptional activator domain TPR_10 PF13374.6 EMC84964.1 - 0.0037 17.1 7.5 21 5.1 0.0 5.7 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_15 PF13429.6 EMC84964.1 - 0.0075 15.5 1.5 0.29 10.3 0.1 3.3 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMC84964.1 - 0.071 13.8 6.4 29 5.6 0.0 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_20 PF14561.6 EMC84964.1 - 1.5 9.2 8.6 4.7 7.6 0.2 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat AAA PF00004.29 EMC84965.1 - 1.2e-96 320.2 0.0 4.8e-47 159.7 0.0 2.6 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMC84965.1 - 9.7e-28 95.7 6.7 3.6e-13 49.1 0.2 3.2 3 0 0 3 3 2 2 AAA+ lid domain CDC48_N PF02359.18 EMC84965.1 - 5.2e-22 77.8 1.6 1.2e-21 76.7 0.5 2.3 3 0 0 3 3 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 EMC84965.1 - 6.3e-14 52.0 0.0 1.7e-05 24.6 0.0 3.3 3 1 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EMC84965.1 - 5.9e-13 49.6 5.8 5.6e-05 23.6 0.1 5.0 4 2 1 5 5 4 2 AAA ATPase domain CDC48_2 PF02933.17 EMC84965.1 - 1.3e-12 47.3 0.0 2.7e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_33 PF13671.6 EMC84965.1 - 1e-10 41.9 0.0 5.4e-05 23.4 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.14 EMC84965.1 - 1.6e-10 41.3 0.0 4e-05 23.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EMC84965.1 - 1.9e-10 40.9 0.3 4.7e-05 23.4 0.0 3.4 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EMC84965.1 - 1.9e-09 37.9 0.9 0.014 15.6 0.1 4.2 3 2 1 4 4 2 2 AAA domain Vps4_C PF09336.10 EMC84965.1 - 7.5e-09 35.5 0.9 3.1e-05 23.9 0.1 2.7 2 0 0 2 2 2 2 Vps4 C terminal oligomerisation domain TIP49 PF06068.13 EMC84965.1 - 8.1e-09 35.1 0.1 0.0013 18.1 0.0 2.7 3 0 0 3 3 2 2 TIP49 P-loop domain AAA_18 PF13238.6 EMC84965.1 - 9.1e-08 32.7 0.0 0.017 15.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 EMC84965.1 - 1.9e-07 31.5 0.0 0.0066 16.8 0.0 3.1 3 0 0 3 3 2 2 RNA helicase Mg_chelatase PF01078.21 EMC84965.1 - 3.3e-07 29.9 0.1 0.019 14.4 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EMC84965.1 - 4.6e-07 29.9 0.0 0.024 14.7 0.0 2.7 3 0 0 3 3 2 2 AAA domain IstB_IS21 PF01695.17 EMC84965.1 - 5.6e-07 29.5 0.1 0.054 13.2 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein Parvo_NS1 PF01057.17 EMC84965.1 - 3.4e-06 26.4 0.1 0.035 13.2 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_28 PF13521.6 EMC84965.1 - 5.4e-06 26.7 0.3 0.18 12.0 0.0 3.1 4 0 0 4 4 2 2 AAA domain ATPase PF06745.13 EMC84965.1 - 5.8e-06 25.8 0.1 0.48 9.7 0.0 3.4 3 0 0 3 3 3 2 KaiC AAA_7 PF12775.7 EMC84965.1 - 6.9e-06 25.7 0.0 0.069 12.7 0.0 2.8 2 1 0 2 2 2 2 P-loop containing dynein motor region ABC_tran PF00005.27 EMC84965.1 - 8.3e-06 26.4 0.1 0.01 16.3 0.0 3.6 3 1 0 3 3 2 1 ABC transporter ATPase_2 PF01637.18 EMC84965.1 - 8.7e-06 25.8 0.7 0.25 11.2 0.0 3.9 3 2 1 5 5 3 1 ATPase domain predominantly from Archaea Bac_DnaA PF00308.18 EMC84965.1 - 9.5e-06 25.6 0.1 0.094 12.5 0.0 3.0 3 1 0 3 3 2 2 Bacterial dnaA protein DUF815 PF05673.13 EMC84965.1 - 1.3e-05 24.5 0.0 0.012 14.8 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_25 PF13481.6 EMC84965.1 - 1.7e-05 24.5 2.5 2 7.9 0.0 3.7 2 2 0 3 3 3 2 AAA domain AAA_24 PF13479.6 EMC84965.1 - 4.1e-05 23.4 0.1 0.086 12.6 0.0 2.7 2 1 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 EMC84965.1 - 5.8e-05 23.0 0.0 0.0019 18.0 0.0 2.8 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase TsaE PF02367.17 EMC84965.1 - 6.4e-05 23.0 0.0 0.29 11.1 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 EMC84965.1 - 7.3e-05 23.2 0.0 0.93 9.9 0.0 3.2 3 0 0 3 3 2 2 AAA domain Sigma54_activat PF00158.26 EMC84965.1 - 0.0001 22.1 0.0 0.44 10.2 0.0 2.9 2 2 0 2 2 2 2 Sigma-54 interaction domain NACHT PF05729.12 EMC84965.1 - 0.00013 21.9 0.1 0.32 10.9 0.0 3.5 3 1 1 4 4 4 1 NACHT domain NB-ARC PF00931.22 EMC84965.1 - 0.00032 20.0 0.0 0.22 10.7 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain Zeta_toxin PF06414.12 EMC84965.1 - 0.00045 19.6 0.0 0.52 9.5 0.0 2.7 2 0 0 2 2 2 1 Zeta toxin DUF2075 PF09848.9 EMC84965.1 - 0.0006 19.2 0.0 0.4 9.9 0.0 2.7 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) AAA_3 PF07726.11 EMC84965.1 - 0.00074 19.4 0.0 1.6 8.6 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 EMC84965.1 - 0.00075 19.5 0.0 0.082 12.9 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PhoH PF02562.16 EMC84965.1 - 0.0011 18.4 0.5 1.8 8.0 0.1 2.5 2 0 0 2 2 2 2 PhoH-like protein Sigma54_activ_2 PF14532.6 EMC84965.1 - 0.0013 18.9 0.0 2.5 8.2 0.0 2.7 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_11 PF13086.6 EMC84965.1 - 0.0024 17.7 0.2 2.3 7.9 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_19 PF13245.6 EMC84965.1 - 0.0044 17.4 1.7 3.2 8.1 0.2 3.4 3 1 0 4 4 2 1 AAA domain Rad17 PF03215.15 EMC84965.1 - 0.005 16.8 0.0 1 9.2 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_30 PF13604.6 EMC84965.1 - 0.02 14.6 0.4 3 7.5 0.1 2.6 2 0 0 2 2 2 0 AAA domain SKI PF01202.22 EMC84965.1 - 0.029 14.5 0.0 5.7 7.0 0.0 2.9 2 0 0 2 2 2 0 Shikimate kinase NTPase_1 PF03266.15 EMC84965.1 - 0.034 14.1 0.2 5.3 6.9 0.0 3.1 3 0 0 3 3 3 0 NTPase UFD1 PF03152.14 EMC84965.1 - 0.044 13.3 0.0 0.1 12.1 0.0 1.5 1 1 0 1 1 1 0 Ubiquitin fusion degradation protein UFD1 Cytidylate_kin PF02224.18 EMC84965.1 - 0.045 13.5 0.0 9.5 5.9 0.0 2.7 2 0 0 2 2 2 0 Cytidylate kinase Zot PF05707.12 EMC84965.1 - 0.11 12.2 0.0 1.4 8.5 0.0 2.6 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) PduV-EutP PF10662.9 EMC84965.1 - 0.13 12.0 0.0 3.3 7.5 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation KAP_NTPase PF07693.14 EMC84965.1 - 0.15 11.3 0.1 4 6.6 0.0 2.7 2 2 1 3 3 3 0 KAP family P-loop domain AAA_23 PF13476.6 EMC84965.1 - 0.18 12.3 0.1 15 6.0 0.0 2.8 2 0 0 2 2 2 0 AAA domain DnaJ_C PF01556.18 EMC84966.1 - 1.8e-45 154.7 0.1 2.4e-45 154.3 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EMC84966.1 - 5.1e-29 100.2 4.4 8.2e-29 99.5 4.4 1.3 1 0 0 1 1 1 1 DnaJ domain Zf_RING PF16744.5 EMC84967.1 - 9.9e-38 128.1 6.5 1.9e-37 127.2 6.5 1.5 1 0 0 1 1 1 1 KIAA1045 RING finger EF-hand_7 PF13499.6 EMC84967.1 - 1.5e-06 28.6 0.0 0.05 14.1 0.0 2.9 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EMC84967.1 - 2.1e-06 27.2 0.1 0.0071 16.2 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EMC84967.1 - 1.2e-05 24.5 0.5 0.11 12.1 0.0 3.2 3 0 0 3 3 3 2 EF hand Zn_ribbon_17 PF17120.5 EMC84967.1 - 6.8e-05 22.4 1.2 6.8e-05 22.4 1.2 2.0 3 0 0 3 3 3 1 Zinc-ribbon, C4HC2 type EF-hand_8 PF13833.6 EMC84967.1 - 0.0059 16.4 0.2 0.62 10.0 0.0 3.1 3 0 0 3 3 3 1 EF-hand domain pair PHD PF00628.29 EMC84967.1 - 0.0087 15.9 6.8 0.033 14.1 6.8 2.0 1 1 0 1 1 1 1 PHD-finger EF-hand_5 PF13202.6 EMC84967.1 - 0.011 15.1 0.4 0.44 10.1 0.3 2.5 2 0 0 2 2 2 0 EF hand C1_1 PF00130.22 EMC84967.1 - 0.017 15.0 0.5 0.017 15.0 0.5 2.4 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_4 PF16866.5 EMC84967.1 - 0.069 13.3 3.8 0.29 11.3 3.8 2.1 1 0 0 1 1 1 0 PHD-finger zf-RING_2 PF13639.6 EMC84967.1 - 0.22 11.9 4.8 0.69 10.3 4.8 1.9 1 0 0 1 1 1 0 Ring finger domain zf-HC5HC2H PF13771.6 EMC84967.1 - 0.31 11.3 3.3 1.1 9.6 3.3 1.9 1 1 0 1 1 1 0 PHD-like zinc-binding domain IL8 PF00048.20 EMC84968.1 - 5.7e-19 68.0 0.3 7.7e-19 67.6 0.3 1.2 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like IL8 PF00048.20 EMC84969.1 - 7.1e-20 70.9 0.6 8.5e-20 70.7 0.6 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like fn3 PF00041.21 EMC84970.1 - 1.7e-07 31.4 1.5 3.9e-07 30.3 0.2 2.3 2 1 0 2 2 2 1 Fibronectin type III domain Ig_5 PF16681.5 EMC84970.1 - 6.7e-06 26.4 0.1 1.6e-05 25.3 0.1 1.6 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_2 PF13895.6 EMC84970.1 - 7.3e-05 23.0 0.2 0.00023 21.4 0.2 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC84970.1 - 0.00021 21.8 0.1 0.00021 21.8 0.1 2.8 3 1 0 3 3 3 1 Immunoglobulin domain Ig_4 PF16680.5 EMC84970.1 - 0.0011 19.2 0.1 0.0022 18.2 0.1 1.5 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 delta chain I-set PF07679.16 EMC84970.1 - 0.0094 16.0 0.3 0.18 11.9 0.1 2.7 2 0 0 2 2 2 1 Immunoglobulin I-set domain IL12p40_C PF10420.9 EMC84970.1 - 0.049 14.1 0.1 0.14 12.6 0.1 1.8 2 0 0 2 2 2 0 Cytokine interleukin-12p40 C-terminus ig PF00047.25 EMC84970.1 - 0.05 13.8 0.2 0.43 10.8 0.1 2.4 2 0 0 2 2 2 0 Immunoglobulin domain ERG2_Sigma1R PF04622.12 EMC84974.1 - 9.9e-65 217.8 0.4 1.2e-64 217.5 0.4 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein ARID PF01388.21 EMC84975.1 - 7.6e-22 77.8 0.0 1.6e-21 76.8 0.0 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain ketoacyl-synt PF00109.26 EMC84975.1 - 0.0086 15.7 0.1 0.012 15.2 0.1 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Dynactin_p22 PF07426.11 EMC84976.1 - 6.5e-40 136.7 5.0 7.3e-40 136.5 5.0 1.0 1 0 0 1 1 1 1 Dynactin subunit p22 Jnk-SapK_ap_N PF09744.9 EMC84976.1 - 0.0022 18.2 0.4 0.0042 17.3 0.2 1.5 1 1 1 2 2 2 2 JNK_SAPK-associated protein-1 Myb_DNA-bind_3 PF12776.7 EMC84976.1 - 0.0099 16.8 0.1 0.013 16.4 0.1 1.2 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain DUF4254 PF14063.6 EMC84976.1 - 0.075 12.8 2.0 0.094 12.5 0.9 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4254) Alba PF01918.21 EMC84978.1 - 4.8e-17 61.5 1.2 6.9e-17 61.0 1.2 1.3 1 0 0 1 1 1 1 Alba Hit1_C PF18268.1 EMC84978.1 - 0.076 13.2 0.1 0.12 12.6 0.1 1.3 1 0 0 1 1 1 0 Hit1 C-terminal WD40 PF00400.32 EMC84980.1 - 4.2e-10 40.0 7.6 0.00099 19.9 1.4 5.0 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC84980.1 - 0.00046 20.4 0.1 3.2 8.1 0.0 3.9 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain FAM219A PF15260.6 EMC84981.1 - 1.8e-54 183.5 2.9 2.2e-54 183.1 2.9 1.1 1 0 0 1 1 1 1 Protein family FAM219A SMRP1 PF15181.6 EMC84982.1 - 1.7e-74 250.8 7.1 1.9e-74 250.6 7.1 1.0 1 0 0 1 1 1 1 Spermatid-specific manchette-related protein 1 Glyco_hydro_31 PF01055.26 EMC84983.1 - 9.7e-58 196.4 1.2 4.1e-34 118.5 0.0 2.2 2 0 0 2 2 2 2 Glycosyl hydrolases family 31 Melibiase PF02065.18 EMC84983.1 - 0.01 14.8 0.3 0.021 13.8 0.1 1.6 2 0 0 2 2 2 0 Melibiase Glyco_hydro_31 PF01055.26 EMC84984.1 - 1.6e-56 192.3 1.6 2.2e-32 112.8 0.0 2.2 2 0 0 2 2 2 2 Glycosyl hydrolases family 31 Melibiase PF02065.18 EMC84984.1 - 0.016 14.2 0.3 0.031 13.2 0.1 1.6 2 0 0 2 2 2 0 Melibiase Ricin_B_lectin PF00652.22 EMC84985.1 - 2.3e-10 40.8 6.4 6.4e-08 32.9 1.2 2.2 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain NUDIX PF00293.28 EMC84987.1 - 7.9e-19 68.0 0.2 8.8e-19 67.8 0.2 1.0 1 0 0 1 1 1 1 NUDIX domain Kinesin PF00225.23 EMC84988.1 - 2e-51 174.9 1.7 4.1e-51 173.9 1.7 1.5 1 0 0 1 1 1 1 Kinesin motor domain SAM_1 PF00536.30 EMC84988.1 - 0.003 18.0 0.1 0.0067 16.8 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC84988.1 - 0.023 14.8 0.1 0.049 13.8 0.1 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) UBA PF00627.31 EMC84989.1 - 4.9e-06 26.3 0.0 0.00014 21.6 0.0 3.1 3 0 0 3 3 3 1 UBA/TS-N domain UBA_3 PF09288.10 EMC84989.1 - 0.0059 16.4 1.4 0.51 10.2 0.0 3.1 3 0 0 3 3 3 1 Fungal ubiquitin-associated domain DUF1421 PF07223.11 EMC84989.1 - 0.1 12.5 0.1 0.33 10.8 0.0 1.9 2 0 0 2 2 2 0 UBA-like domain (DUF1421) DUF3697 PF12478.8 EMC84990.1 - 4.2e-17 61.9 0.5 9.9e-17 60.8 0.5 1.7 1 0 0 1 1 1 1 Ubiquitin-associated protein 2 UBA_4 PF14555.6 EMC84990.1 - 5.7e-05 22.8 0.0 0.00012 21.8 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain DUF1296 PF06972.11 EMC84990.1 - 0.0051 16.9 0.1 0.012 15.7 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1296) UBA PF00627.31 EMC84990.1 - 0.013 15.4 0.0 0.026 14.4 0.0 1.5 1 0 0 1 1 1 0 UBA/TS-N domain DUF1510 PF07423.11 EMC84990.1 - 0.025 14.7 0.2 0.025 14.7 0.2 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF1510) CUE PF02845.16 EMC84990.1 - 0.079 12.7 1.7 0.12 12.1 0.1 2.2 2 0 0 2 2 2 0 CUE domain HOIP-UBA PF16678.5 EMC84990.1 - 0.13 12.3 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 HOIP UBA domain pair API5 PF05918.11 EMC84990.1 - 0.34 9.7 6.3 0.64 8.8 6.3 1.6 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) ZNRF_3_ecto PF18212.1 EMC84991.1 - 9.6e-50 166.9 0.0 1.6e-49 166.2 0.0 1.4 1 0 0 1 1 1 1 ZNRF-3 Ectodomain zf-RING_2 PF13639.6 EMC84991.1 - 1.7e-12 47.5 9.1 1.7e-12 47.5 9.1 2.7 3 0 0 3 3 2 1 Ring finger domain zf-RING_11 PF17123.5 EMC84991.1 - 2.2e-10 40.1 4.6 2.2e-10 40.1 4.6 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EMC84991.1 - 1.7e-09 37.3 7.6 1.7e-09 37.3 7.6 2.5 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC84991.1 - 2.8e-07 30.3 7.7 2.8e-07 30.3 7.7 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMC84991.1 - 2.4e-06 27.7 13.7 2.9e-06 27.4 10.9 2.7 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EMC84991.1 - 9.9e-06 25.5 5.1 9.9e-06 25.5 5.1 2.7 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMC84991.1 - 3.2e-05 23.8 6.7 0.00014 21.8 6.7 2.1 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC84991.1 - 0.00011 22.0 6.0 0.00042 20.1 6.0 2.1 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EMC84991.1 - 0.014 15.2 4.3 0.014 15.2 4.3 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF3827 PF12877.7 EMC84991.1 - 0.015 13.7 0.5 0.022 13.2 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) FANCL_C PF11793.8 EMC84991.1 - 0.054 13.7 4.2 0.18 12.0 4.3 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain DUF5305 PF17231.2 EMC84991.1 - 0.054 12.9 0.1 0.082 12.3 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5305) zf-ANAPC11 PF12861.7 EMC84991.1 - 0.093 12.8 7.3 0.52 10.4 7.3 2.4 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 EMC84991.1 - 0.79 9.9 4.5 3.6 7.8 4.5 2.2 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING PHD PF00628.29 EMC84991.1 - 3.4 7.6 12.4 1.5 8.8 6.6 2.7 2 0 0 2 2 2 0 PHD-finger RINGv PF12906.7 EMC84991.1 - 3.6 7.8 8.8 14 5.9 8.8 2.1 1 0 0 1 1 1 0 RING-variant domain Spt4 PF06093.13 EMC84992.1 - 1.2e-09 38.2 0.1 1.5e-09 37.9 0.1 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger SH3_9 PF14604.6 EMC84993.1 - 1.1e-11 44.4 0.1 2.1e-11 43.5 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain fn3 PF00041.21 EMC84993.1 - 7.2e-10 39.1 2.0 0.0034 17.7 0.0 4.5 3 1 0 3 3 3 2 Fibronectin type III domain SH3_2 PF07653.17 EMC84993.1 - 2.1e-09 36.9 0.0 4.4e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC84993.1 - 0.0051 16.4 0.0 0.012 15.2 0.0 1.6 1 0 0 1 1 1 1 SH3 domain Pur_ac_phosph_N PF16656.5 EMC84993.1 - 0.026 15.1 0.2 1.6 9.4 0.1 2.8 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain fn3_4 PF16794.5 EMC84993.1 - 0.095 12.6 0.0 0.46 10.4 0.0 2.1 2 0 0 2 2 2 0 Fibronectin-III type domain An_peroxidase PF03098.15 EMC84994.1 - 7.1e-177 589.2 0.0 8.6e-177 588.9 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase Acyltransferase PF01553.21 EMC84995.1 - 5.5e-34 116.7 0.1 8.2e-34 116.1 0.1 1.3 1 0 0 1 1 1 1 Acyltransferase An_peroxidase PF03098.15 EMC84996.1 - 2.3e-186 620.5 0.0 2.7e-186 620.3 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase IL8 PF00048.20 EMC84997.1 - 1.3e-24 86.1 0.8 1.7e-24 85.7 0.8 1.2 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like PRY PF13765.6 EMC84998.1 - 5.8e-18 64.3 0.9 9.3e-18 63.6 0.1 1.8 2 0 0 2 2 2 1 SPRY-associated domain SPRY PF00622.28 EMC84998.1 - 2e-16 60.2 0.0 3.8e-16 59.3 0.0 1.4 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.6 EMC84998.1 - 2.4e-13 50.0 11.0 2.4e-13 50.0 11.0 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EMC84998.1 - 1.1e-10 41.3 8.4 1.1e-10 41.3 8.4 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EMC84998.1 - 8.1e-09 35.2 9.5 8.1e-09 35.2 9.5 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 EMC84998.1 - 1.3e-08 34.9 3.0 1.3e-08 34.9 3.0 3.4 3 1 0 3 3 3 1 B-box zinc finger zf-RING_2 PF13639.6 EMC84998.1 - 1.8e-06 28.2 10.2 1.8e-06 28.2 10.2 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC84998.1 - 1.8e-05 24.5 10.2 1.8e-05 24.5 10.2 2.5 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMC84998.1 - 0.0004 20.2 11.7 0.0004 20.2 11.7 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) U-box PF04564.15 EMC84998.1 - 0.0052 16.9 0.0 0.019 15.2 0.0 1.9 2 0 0 2 2 1 1 U-box domain zf-RING_10 PF16685.5 EMC84998.1 - 0.0056 16.8 4.9 0.0056 16.8 4.9 3.0 3 1 0 3 3 3 1 zinc RING finger of MSL2 zf-Nse PF11789.8 EMC84998.1 - 0.0071 16.1 3.1 0.018 14.8 3.1 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_5 PF14634.6 EMC84998.1 - 0.015 15.2 9.0 0.015 15.2 9.0 2.8 2 1 1 3 3 3 0 zinc-RING finger domain Hemopexin PF00045.19 EMC84998.1 - 0.044 13.7 0.1 0.13 12.2 0.1 1.7 1 0 0 1 1 1 0 Hemopexin YscO PF07321.12 EMC84998.1 - 0.45 10.5 13.9 0.81 9.6 13.9 1.4 1 0 0 1 1 1 0 Type III secretion protein YscO zf-RING_6 PF14835.6 EMC84998.1 - 0.69 9.8 6.5 1.9 8.4 6.5 1.8 1 1 0 1 1 1 0 zf-RING of BARD1-type protein E3_UbLigase_R4 PF13764.6 EMC84998.1 - 4.9 5.2 10.5 0.11 10.6 0.2 2.2 1 1 1 2 2 2 0 E3 ubiquitin-protein ligase UBR4 Prok-RING_4 PF14447.6 EMC84998.1 - 8.1 6.4 16.5 3.6 7.5 12.2 2.5 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 IL8 PF00048.20 EMC84999.1 - 7.5e-18 64.4 0.1 1.3e-17 63.7 0.1 1.3 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like DUF1450 PF07293.11 EMC84999.1 - 0.068 13.0 0.0 0.086 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1450) Methyltr_RsmB-F PF01189.17 EMC85000.1 - 2.8e-34 118.5 0.0 3.6e-34 118.2 0.0 1.1 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EMC85000.1 - 0.00039 20.6 0.0 0.00052 20.2 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 EMC85000.1 - 0.0078 16.0 0.0 0.018 14.8 0.0 1.5 1 1 1 2 2 2 1 Methyltransferase domain tRNA_bind_3 PF17176.4 EMC85000.1 - 0.015 15.6 0.2 0.042 14.1 0.1 1.8 2 0 0 2 2 2 0 tRNA-binding domain Methyltransf_25 PF13649.6 EMC85000.1 - 0.018 15.7 0.0 0.038 14.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 EMC85000.1 - 0.12 11.6 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Fibrillarin PF01269.17 EMC85000.1 - 0.18 10.9 0.0 0.29 10.2 0.0 1.2 1 0 0 1 1 1 0 Fibrillarin SPRY PF00622.28 EMC85001.1 - 2.2e-13 50.4 0.0 4e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.6 EMC85001.1 - 3.2e-12 46.4 9.5 3.2e-12 46.4 9.5 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EMC85001.1 - 4.1e-12 45.9 3.3 4.1e-12 45.9 3.3 2.4 2 1 0 2 2 1 1 RING-type zinc-finger zf-B_box PF00643.24 EMC85001.1 - 1.3e-10 41.3 1.7 1.3e-10 41.3 1.7 4.0 4 0 0 4 4 4 1 B-box zinc finger zf-C3HC4 PF00097.25 EMC85001.1 - 2.3e-10 40.1 6.0 8.5e-10 38.4 6.0 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PRY PF13765.6 EMC85001.1 - 7e-09 35.2 0.1 1.6e-08 34.0 0.1 1.7 1 0 0 1 1 1 1 SPRY-associated domain zf-C3HC4_3 PF13920.6 EMC85001.1 - 8.6e-09 35.1 8.0 8.6e-09 35.1 8.0 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC85001.1 - 1.2e-08 34.7 8.6 6.8e-08 32.2 7.3 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC85001.1 - 4.1e-07 29.8 5.7 4.1e-07 29.8 5.7 2.8 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.6 EMC85001.1 - 1.4e-06 28.5 7.1 1.4e-06 28.5 7.1 2.5 3 0 0 3 3 1 1 Ring finger domain zf-Nse PF11789.8 EMC85001.1 - 0.0045 16.8 2.5 0.0045 16.8 2.5 2.2 2 0 0 2 2 1 1 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 EMC85001.1 - 0.012 15.4 9.5 0.012 15.4 9.5 2.2 2 0 0 2 2 1 0 Prokaryotic RING finger family 4 XhlA PF10779.9 EMC85001.1 - 0.014 15.6 2.5 0.093 13.0 0.3 2.3 2 0 0 2 2 2 0 Haemolysin XhlA Muted PF14942.6 EMC85001.1 - 0.016 15.5 0.4 1.8 8.9 0.0 2.2 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein U-box PF04564.15 EMC85001.1 - 0.017 15.3 0.0 0.041 14.1 0.0 1.6 1 0 0 1 1 1 0 U-box domain FAM178 PF14816.6 EMC85001.1 - 0.024 13.6 0.1 0.038 13.0 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function, FAM178 zf-RING_4 PF14570.6 EMC85001.1 - 0.03 14.1 4.5 0.27 11.0 5.1 2.3 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain DUF4795 PF16043.5 EMC85001.1 - 0.054 13.1 1.4 0.086 12.4 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) Trimer_CC PF08954.11 EMC85001.1 - 0.056 13.0 0.7 0.29 10.7 0.0 2.3 2 0 0 2 2 2 0 Trimerisation motif Dynactin_p22 PF07426.11 EMC85001.1 - 0.14 12.0 2.4 0.29 11.0 1.9 1.6 1 1 1 2 2 2 0 Dynactin subunit p22 PTPA PF03095.15 EMC85001.1 - 0.2 11.1 1.0 0.28 10.6 1.0 1.1 1 0 0 1 1 1 0 Phosphotyrosyl phosphate activator (PTPA) protein DUF5082 PF16888.5 EMC85001.1 - 0.28 11.5 4.4 6.1 7.2 1.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) zf-rbx1 PF12678.7 EMC85001.1 - 0.3 11.4 4.5 1.9 8.8 4.5 2.3 1 1 0 1 1 1 0 RING-H2 zinc finger domain DUF16 PF01519.16 EMC85001.1 - 0.82 10.2 3.2 0.81 10.2 1.5 1.7 1 1 0 1 1 1 0 Protein of unknown function DUF16 Prefoldin_2 PF01920.20 EMC85001.1 - 1.5 8.8 5.8 15 5.6 1.3 2.2 2 0 0 2 2 2 0 Prefoldin subunit zf-ANAPC11 PF12861.7 EMC85001.1 - 2.7 8.1 7.7 0.29 11.2 2.7 2.0 2 1 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 EMC85001.1 - 4.3 7.3 13.9 1.6 8.7 6.4 2.7 3 0 0 3 3 2 0 zf-RING of BARD1-type protein FKBP_C PF00254.28 EMC85002.1 - 8.9e-16 58.0 0.0 1.6e-15 57.2 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.17 EMC85002.1 - 4.1e-07 29.6 5.6 0.001 19.0 0.3 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EMC85002.1 - 7.7e-07 29.3 1.5 0.00012 22.2 0.2 3.1 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EMC85002.1 - 0.00027 20.9 0.4 0.012 15.7 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 EMC85002.1 - 0.0085 15.9 0.2 0.05 13.5 0.2 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EMC85002.1 - 0.016 15.0 4.6 0.12 12.2 0.2 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EMC85002.1 - 0.12 12.4 1.5 3.1 8.1 0.4 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMC85002.1 - 0.14 12.2 3.0 0.19 11.8 0.1 2.4 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat Bromodomain PF00439.25 EMC85004.1 - 9.5e-23 80.1 1.7 1.1e-22 79.9 0.2 1.9 2 0 0 2 2 2 1 Bromodomain WSD PF15613.6 EMC85004.1 - 4e-19 68.9 0.0 4e-19 68.9 0.0 4.6 4 2 0 4 4 3 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif PHD PF00628.29 EMC85004.1 - 6e-13 48.5 5.9 6e-13 48.5 5.9 2.0 2 0 0 2 2 1 1 PHD-finger WHIM1 PF15612.6 EMC85004.1 - 6.6e-08 31.9 2.0 1.5e-07 30.8 0.1 2.8 3 0 0 3 3 3 1 WSTF, HB1, Itc1p, MBD9 motif 1 DDT PF02791.17 EMC85004.1 - 0.00061 20.1 1.3 0.0012 19.1 0.3 2.0 2 0 0 2 2 2 1 DDT domain zf-HC5HC2H PF13771.6 EMC85004.1 - 0.015 15.6 3.3 0.064 13.5 3.3 2.1 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-ANAPC11 PF12861.7 EMC85004.1 - 0.023 14.7 1.7 0.058 13.4 1.7 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EMC85004.1 - 0.029 14.7 5.9 0.076 13.4 5.9 1.8 1 0 0 1 1 1 0 Ring finger domain PHD_2 PF13831.6 EMC85004.1 - 0.035 13.6 0.4 0.091 12.3 0.4 1.8 1 0 0 1 1 1 0 PHD-finger zf-rbx1 PF12678.7 EMC85004.1 - 0.059 13.7 6.7 0.18 12.1 6.7 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger domain Prok-RING_1 PF14446.6 EMC85004.1 - 0.74 9.8 10.5 0.026 14.5 1.5 2.7 3 0 0 3 3 2 0 Prokaryotic RING finger family 1 PHD_4 PF16866.5 EMC85004.1 - 1.1 9.4 5.6 7.7 6.7 5.6 2.6 1 0 0 1 1 1 0 PHD-finger C1_2 PF03107.16 EMC85004.1 - 1.3 9.3 7.7 0.67 10.3 4.5 2.2 2 0 0 2 2 2 0 C1 domain zf-C3HC4 PF00097.25 EMC85004.1 - 9 6.3 8.7 7.1 6.6 5.3 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) WAC_Acf1_DNA_bd PF10537.9 EMC85005.1 - 3e-05 24.5 0.0 5e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal Fibrinogen_C PF00147.18 EMC85007.1 - 4.8e-81 271.8 5.6 5.2e-41 140.9 0.5 2.0 2 0 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain Ephrin_lbd PF01404.19 EMC85007.1 - 0.004 17.2 8.8 0.11 12.5 0.8 2.3 2 0 0 2 2 2 2 Ephrin receptor ligand binding domain ImpE PF07024.13 EMC85007.1 - 0.036 14.1 0.0 10 6.2 0.0 2.5 2 0 0 2 2 2 0 ImpE protein Ubiquitin_4 PF18036.1 EMC85007.1 - 2.1 8.4 4.8 23 5.1 0.2 2.3 2 0 0 2 2 2 0 Ubiquitin-like domain PT PF04886.12 EMC85008.1 - 9.8e-11 41.0 0.0 0.011 15.3 0.0 4.1 1 1 0 1 1 1 1 PT repeat WD40 PF00400.32 EMC85009.1 - 2.5e-17 62.9 0.6 0.00012 22.8 0.1 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EMC85009.1 - 0.013 14.5 0.2 0.14 11.1 0.0 2.6 1 1 3 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Syndecan PF01034.20 EMC85009.1 - 0.086 12.8 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain Utp8 PF10395.9 EMC85009.1 - 0.1 11.1 0.0 0.7 8.3 0.0 1.9 1 1 0 2 2 2 0 Utp8 family eIF2A PF08662.11 EMC85009.1 - 0.11 12.3 0.0 0.78 9.6 0.0 2.4 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A CRAM_rpt PF07016.11 EMC85009.1 - 0.15 11.9 0.1 0.3 10.9 0.1 1.5 1 0 0 1 1 1 0 Cysteine-rich acidic integral membrane protein precursor DUF1797 PF08796.10 EMC85009.1 - 0.24 11.5 0.4 7.8 6.7 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1797) B9-C2 PF07162.11 EMC85011.1 - 8.6e-41 139.9 0.0 1.1e-40 139.6 0.0 1.1 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein DUF4175 PF13779.6 EMC85011.1 - 0.059 11.3 0.3 0.078 10.9 0.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Syntaxin PF00804.25 EMC85013.1 - 1.9e-54 184.4 7.2 1.3e-47 162.1 6.4 2.3 2 0 0 2 2 2 2 Syntaxin SNARE PF05739.19 EMC85013.1 - 9.7e-22 76.7 4.0 2.2e-21 75.6 1.9 2.2 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.6 EMC85013.1 - 5.3e-05 23.5 4.2 0.00099 19.4 0.3 3.3 2 1 1 3 3 3 1 Syntaxin-like protein Prominin PF05478.11 EMC85013.1 - 0.008 14.2 3.6 0.0058 14.7 2.4 1.4 2 0 0 2 2 2 1 Prominin GNVR PF13807.6 EMC85013.1 - 0.012 15.5 0.2 0.055 13.4 0.1 2.0 2 0 0 2 2 2 0 G-rich domain on putative tyrosine kinase Lzipper-MIP1 PF14389.6 EMC85013.1 - 0.02 15.2 0.2 0.042 14.1 0.2 1.5 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 DUF16 PF01519.16 EMC85013.1 - 0.073 13.6 2.2 0.5 10.9 0.4 2.5 2 1 0 2 2 2 0 Protein of unknown function DUF16 HAUS6_N PF14661.6 EMC85013.1 - 0.17 11.5 1.7 2.1 7.9 2.4 2.2 2 1 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus CorA PF01544.18 EMC85013.1 - 0.53 9.6 5.2 5.5 6.2 0.3 2.4 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein ETRAMP PF09716.10 EMC85013.1 - 0.64 10.1 2.4 0.84 9.7 0.7 1.8 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DLP_helical PF18709.1 EMC85013.1 - 1 8.5 10.6 0.47 9.6 0.3 2.4 2 1 0 2 2 2 0 Dynamin-like helical domain DUF1910 PF08928.10 EMC85013.1 - 1.7 8.7 6.5 0.47 10.5 0.9 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF1910) WBS_methylT PF12589.8 EMC85014.1 - 1.9e-16 60.6 10.9 6.2e-16 58.9 10.9 1.8 1 1 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 EMC85014.1 - 1.6e-10 41.5 0.0 2.5e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC85014.1 - 8.8e-10 39.2 0.0 1.5e-09 38.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC85014.1 - 0.00023 21.9 0.0 0.00036 21.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC85014.1 - 0.00039 20.3 0.0 0.00063 19.6 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC85014.1 - 0.046 13.5 0.0 0.062 13.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Mod_r PF07200.13 EMC85015.1 - 3e-12 46.9 0.4 4.2e-12 46.4 0.1 1.4 1 1 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein Mod_r PF07200.13 EMC85016.1 - 6.5e-12 45.8 0.5 7.2e-12 45.6 0.5 1.0 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein Fibrinogen_C PF00147.18 EMC85017.1 - 9.8e-54 182.5 3.8 1.1e-53 182.4 3.8 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 EMC85018.1 - 2.1e-51 174.8 2.2 2.3e-51 174.7 2.2 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Ephrin_lbd PF01404.19 EMC85018.1 - 0.06 13.4 1.6 0.075 13.1 1.0 1.4 2 0 0 2 2 2 0 Ephrin receptor ligand binding domain TLV_coat PF00429.19 EMC85019.1 - 1.8e-10 40.2 0.4 2e-10 40.0 0.4 1.0 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) PLAC8 PF04749.17 EMC85020.1 - 1.7e-09 38.5 16.7 1.7e-08 35.4 16.7 2.0 1 1 0 1 1 1 1 PLAC8 family zf-CXXC PF02008.20 EMC85020.1 - 3 7.9 15.8 4 7.6 6.2 2.3 1 1 1 2 2 2 0 CXXC zinc finger domain PLAC8 PF04749.17 EMC85021.1 - 6.8e-14 52.7 15.2 1.5e-13 51.6 15.2 1.6 1 1 0 1 1 1 1 PLAC8 family ABC2_membrane PF01061.24 EMC85022.1 - 1.9e-39 135.3 24.1 1.9e-39 135.3 24.1 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 EMC85022.1 - 7.9e-22 78.2 0.0 1.4e-21 77.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EMC85022.1 - 5.2e-07 29.8 0.8 0.0024 17.7 0.2 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EMC85022.1 - 8e-06 25.4 0.1 0.00017 21.1 0.1 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EMC85022.1 - 8.8e-05 23.1 0.6 0.0004 20.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EMC85022.1 - 0.0032 17.2 0.1 0.0084 15.8 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC2_membrane_3 PF12698.7 EMC85022.1 - 0.0036 16.5 28.5 0.0096 15.1 28.5 1.7 1 1 0 1 1 1 1 ABC-2 family transporter protein RsgA_GTPase PF03193.16 EMC85022.1 - 0.012 15.5 0.0 0.04 13.8 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase PDR_assoc PF08370.11 EMC85022.1 - 0.025 14.3 0.1 0.11 12.3 0.1 2.1 1 0 0 1 1 1 0 Plant PDR ABC transporter associated DUF87 PF01935.17 EMC85022.1 - 0.63 10.1 3.3 0.59 10.2 0.1 2.2 2 1 0 2 2 2 0 Helicase HerA, central domain ABC2_membrane_2 PF12679.7 EMC85022.1 - 2 7.7 15.9 3.5 6.8 13.2 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein PKD_channel PF08016.12 EMC85023.1 - 1.5e-149 498.3 25.4 1.5e-149 498.3 25.4 2.3 2 1 0 2 2 2 1 Polycystin cation channel Ion_trans PF00520.31 EMC85023.1 - 3.3e-23 82.2 29.7 3.3e-23 82.2 29.7 1.9 2 0 0 2 2 2 1 Ion transport protein Fer4_24 PF18109.1 EMC85023.1 - 6.4e-11 42.3 0.4 1.5e-10 41.1 0.4 1.7 1 0 0 1 1 1 1 Ferredoxin I 4Fe-4S cluster domain EF-hand_1 PF00036.32 EMC85023.1 - 1.9e-05 23.9 1.7 0.022 14.3 0.3 3.7 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 EMC85023.1 - 0.0059 16.5 1.8 0.07 13.1 0.1 3.3 4 0 0 4 4 4 1 EF-hand domain EF-hand_8 PF13833.6 EMC85023.1 - 0.018 14.9 0.3 0.46 10.4 0.4 2.7 2 0 0 2 2 2 0 EF-hand domain pair DUF445 PF04286.12 EMC85023.1 - 0.59 9.9 8.1 5 6.8 8.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF445) EF-hand_7 PF13499.6 EMC85023.1 - 2.2 8.8 7.4 1.8 9.1 1.2 3.3 1 1 2 3 3 3 0 EF-hand domain pair Osteopontin PF00865.18 EMC85024.1 - 1.2e-10 41.3 37.2 1.7e-05 24.5 22.9 3.2 1 1 1 2 2 2 2 Osteopontin BSP_II PF05432.11 EMC85026.1 - 5.7e-68 229.8 44.8 7e-68 229.5 44.8 1.1 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) SAPS PF04499.15 EMC85026.1 - 0.016 14.0 8.0 0.019 13.8 8.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Retinal PF15449.6 EMC85026.1 - 0.066 11.0 7.4 0.093 10.5 7.4 1.2 1 0 0 1 1 1 0 Retinal protein RNA_polI_A34 PF08208.11 EMC85026.1 - 0.17 12.0 14.1 0.39 10.8 11.9 2.0 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 PA26 PF04636.13 EMC85026.1 - 1.1 8.1 5.1 1.5 7.7 5.1 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) GREB1 PF15782.5 EMC85026.1 - 2.3 5.2 6.2 2.8 4.9 6.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Drc1-Sld2 PF11719.8 EMC85026.1 - 2.9 7.3 16.2 0.65 9.5 12.8 1.6 2 0 0 2 2 2 0 DNA replication and checkpoint protein Tim54 PF11711.8 EMC85026.1 - 3.1 6.5 12.5 5.6 5.7 12.5 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Presenilin PF01080.17 EMC85026.1 - 7.9 5.1 13.9 15 4.2 13.9 1.4 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 EMC85026.1 - 8.6 4.4 9.1 11 4.0 9.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF1387 PF07139.11 EMC85026.1 - 8.8 6.0 14.6 13 5.4 14.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) SPARC_Ca_bdg PF10591.9 EMC85027.1 - 6.2e-41 139.3 1.7 6.2e-41 139.3 1.7 3.3 4 1 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region Kazal_1 PF00050.21 EMC85027.1 - 8.7e-14 51.3 6.5 2.4e-13 49.9 6.5 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 EMC85027.1 - 1.3e-09 38.1 2.9 1.3e-09 38.1 2.9 2.2 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain FOLN PF09289.10 EMC85027.1 - 9.8e-09 35.2 8.4 3e-08 33.7 8.4 1.9 1 0 0 1 1 1 1 Follistatin/Osteonectin-like EGF domain EF-hand_1 PF00036.32 EMC85027.1 - 0.013 15.0 0.3 0.47 10.1 0.1 2.5 2 0 0 2 2 2 0 EF hand NUDIX PF00293.28 EMC85028.1 - 1.6e-08 34.6 0.1 3.1e-08 33.7 0.1 1.5 1 0 0 1 1 1 1 NUDIX domain L27 PF02828.16 EMC85028.1 - 0.2 11.5 0.3 0.33 10.8 0.3 1.3 1 0 0 1 1 1 0 L27 domain adh_short PF00106.25 EMC85029.1 - 1.1e-48 165.3 0.2 1.5e-48 164.8 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC85029.1 - 1.1e-31 110.2 0.2 1.5e-31 109.7 0.2 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC85029.1 - 8.4e-10 38.8 0.4 1.5e-09 38.0 0.4 1.3 1 0 0 1 1 1 1 KR domain Rop PF01815.16 EMC85029.1 - 0.033 14.1 0.0 0.06 13.2 0.0 1.4 1 0 0 1 1 1 0 Rop protein Methyltransf_25 PF13649.6 EMC85029.1 - 0.054 14.2 0.1 0.31 11.8 0.1 2.2 1 1 1 2 2 2 0 Methyltransferase domain Ldh_1_N PF00056.23 EMC85029.1 - 0.063 13.4 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain adh_short PF00106.25 EMC85030.1 - 1.2e-48 165.2 0.2 1.7e-48 164.7 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC85030.1 - 9.4e-32 110.4 0.1 1.3e-31 110.0 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC85030.1 - 1.4e-09 38.1 0.3 2.4e-09 37.3 0.3 1.2 1 0 0 1 1 1 1 KR domain Rop PF01815.16 EMC85030.1 - 0.03 14.2 0.0 0.06 13.2 0.0 1.5 1 0 0 1 1 1 0 Rop protein Methyltransf_25 PF13649.6 EMC85030.1 - 0.062 14.0 0.1 0.24 12.1 0.1 2.1 1 1 0 1 1 1 0 Methyltransferase domain Ldh_1_N PF00056.23 EMC85030.1 - 0.072 13.2 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Kelch_1 PF01344.25 EMC85031.1 - 3.9e-75 247.2 13.5 1.2e-15 56.8 0.1 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EMC85031.1 - 2.3e-43 145.1 4.7 2.4e-08 34.0 0.0 6.5 3 2 3 6 6 6 6 Kelch motif Kelch_2 PF07646.15 EMC85031.1 - 2.9e-30 103.1 8.4 1e-05 25.3 0.0 6.5 6 0 0 6 6 6 6 Kelch motif BACK PF07707.15 EMC85031.1 - 8.2e-29 99.7 0.8 8.2e-29 99.7 0.8 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_3 PF13415.6 EMC85031.1 - 6e-27 93.4 9.5 0.00026 21.2 0.0 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain BTB PF00651.31 EMC85031.1 - 1.7e-24 86.2 1.4 1.7e-24 86.2 1.4 1.9 2 1 1 3 3 3 1 BTB/POZ domain Kelch_4 PF13418.6 EMC85031.1 - 6.2e-24 83.7 5.1 6.5e-05 22.9 0.0 6.1 5 2 2 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC85031.1 - 2.2e-05 24.3 6.7 2.2 8.3 0.0 5.2 5 0 0 5 5 5 3 Kelch motif AF-4 PF05110.13 EMC85032.1 - 0 1553.4 95.7 0 1553.2 95.7 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein ANKH PF07260.11 EMC85032.1 - 0.18 11.0 0.0 0.27 10.4 0.0 1.2 1 0 0 1 1 1 0 Progressive ankylosis protein (ANKH) BRD4_CDT PF17105.5 EMC85032.1 - 9.4 5.9 8.6 0.3 10.7 1.8 2.2 2 0 0 2 2 2 0 C-terminal domain of bromodomain protein 4 PDZ PF00595.24 EMC85033.1 - 9.7e-76 250.2 5.3 3.9e-18 65.6 1.0 5.6 5 0 0 5 5 5 5 PDZ domain Y_phosphatase PF00102.27 EMC85033.1 - 6e-74 248.6 0.0 1e-73 247.8 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTN13_u3 PF16599.5 EMC85033.1 - 3.1e-69 232.9 22.5 3.1e-69 232.9 22.5 2.9 3 0 0 3 3 2 1 Unstructured linker region on PTN13 protein between PDZ PDZ_6 PF17820.1 EMC85033.1 - 1e-45 153.4 2.3 1.6e-09 37.5 0.0 5.6 5 0 0 5 5 5 5 PDZ domain FERM_M PF00373.18 EMC85033.1 - 8.8e-28 97.1 1.5 3.2e-27 95.3 1.5 2.1 1 0 0 1 1 1 1 FERM central domain FERM_C PF09380.10 EMC85033.1 - 4.4e-22 78.3 1.4 8.2e-21 74.2 0.3 2.5 2 0 0 2 2 2 1 FERM C-terminal PH-like domain PDZ_2 PF13180.6 EMC85033.1 - 1.6e-20 73.2 1.7 0.00018 21.8 0.0 5.3 5 0 0 5 5 5 4 PDZ domain FERM_N PF09379.10 EMC85033.1 - 3e-16 59.1 1.2 9e-16 57.6 0.1 2.5 3 0 0 3 3 3 1 FERM N-terminal domain KIND PF16474.5 EMC85033.1 - 4.2e-05 23.5 0.0 0.00038 20.4 0.0 2.4 1 1 1 2 2 2 1 Kinase non-catalytic C-lobe domain DSPc PF00782.20 EMC85033.1 - 0.0019 18.0 0.6 0.0074 16.1 0.0 2.3 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EMC85033.1 - 0.023 14.8 0.0 0.08 13.1 0.0 1.9 1 0 0 1 1 1 0 Inositol hexakisphosphate Pkinase PF00069.25 EMC85034.1 - 2.8e-65 220.3 0.0 3.6e-65 220.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC85034.1 - 3.9e-31 108.3 0.1 5.4e-31 107.8 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMC85034.1 - 1.9e-07 30.7 0.2 2.9e-07 30.1 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EMC85034.1 - 6.2e-05 22.5 0.0 0.00013 21.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EMC85034.1 - 0.00032 20.4 0.2 0.0006 19.5 0.2 1.5 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 EMC85034.1 - 0.00063 19.7 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 EMC85034.1 - 0.072 12.7 0.1 0.14 11.8 0.1 1.7 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 EMC85034.1 - 0.094 11.6 0.7 0.22 10.4 0.7 1.6 1 1 0 1 1 1 0 Haspin like kinase domain RhoGAP PF00620.27 EMC85035.1 - 3.3e-49 166.6 0.0 8.3e-49 165.3 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain FPP PF05911.11 EMC85035.1 - 0.0004 18.7 11.9 0.0006 18.1 11.9 1.2 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil PH PF00169.29 EMC85035.1 - 0.0021 18.6 2.6 0.0028 18.2 0.1 2.4 3 0 0 3 3 3 1 PH domain ATG16 PF08614.11 EMC85035.1 - 0.01 16.1 11.5 0.01 16.1 11.5 2.0 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) ADIP PF11559.8 EMC85035.1 - 0.091 12.8 9.5 0.21 11.7 9.5 1.5 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF3435 PF11917.8 EMC85035.1 - 0.1 11.5 5.4 0.17 10.8 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) DMPK_coil PF08826.10 EMC85035.1 - 3.3 7.9 16.3 5.1 7.3 6.9 2.9 1 1 1 2 2 2 0 DMPK coiled coil domain like bZIP_1 PF00170.21 EMC85035.1 - 8.8 6.5 13.4 1.1 9.4 3.9 3.6 2 1 2 4 4 4 0 bZIP transcription factor CSN4_RPN5_eIF3a PF18420.1 EMC85037.1 - 3.1e-25 88.1 3.7 8.3e-25 86.7 3.7 1.8 1 0 0 1 1 1 1 CSN4/RPN5/eIF3a helix turn helix domain PCI PF01399.27 EMC85037.1 - 4.3e-18 65.7 3.3 9.4e-18 64.7 0.0 2.7 3 1 0 3 3 3 1 PCI domain RPN7 PF10602.9 EMC85037.1 - 0.0037 17.0 1.1 0.0069 16.1 1.1 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 TPR_12 PF13424.6 EMC85037.1 - 0.015 15.5 1.1 0.9 9.9 0.1 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EMC85037.1 - 0.029 14.4 1.1 3.2 8.0 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EMC85037.1 - 0.098 12.9 1.3 3 8.3 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat YabA PF06156.13 EMC85037.1 - 2.2 9.0 7.5 5 7.8 0.4 3.5 3 1 1 4 4 4 0 Initiation control protein YabA TPR_14 PF13428.6 EMC85037.1 - 6.2 7.9 7.6 3.2 8.8 0.1 3.9 4 1 1 5 5 5 0 Tetratricopeptide repeat TCR PF03638.15 EMC85038.1 - 1.6e-22 79.5 59.0 9e-13 48.3 22.9 2.7 3 0 0 3 3 3 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain MSL2-CXC PF16682.5 EMC85038.1 - 0.11 12.6 45.0 0.35 11.0 17.1 2.7 2 0 0 2 2 2 0 CXC domain of E3 ubiquitin-protein ligase MSL2 GPHR_N PF12537.8 EMC85039.1 - 0.15 12.1 0.1 0.34 11.0 0.1 1.6 1 0 0 1 1 1 0 The Golgi pH Regulator (GPHR) Family N-terminal FA_desaturase PF00487.24 EMC85040.1 - 1.1e-17 64.7 11.5 1.4e-17 64.4 11.5 1.1 1 0 0 1 1 1 1 Fatty acid desaturase Frag1 PF10277.9 EMC85041.1 - 3.3e-44 151.0 7.3 3.9e-44 150.8 7.3 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family DUF998 PF06197.13 EMC85041.1 - 0.073 12.7 10.6 0.008 15.8 5.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF998) Hydrolase PF00702.26 EMC85042.1 - 0.00034 21.0 0.0 0.00038 20.8 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EMC85042.1 - 0.016 15.3 0.0 0.027 14.6 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase RRM_1 PF00076.22 EMC85043.1 - 2.7e-34 116.8 0.1 2.5e-16 59.3 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMC85043.1 - 1.9e-18 66.4 0.1 8.1e-10 38.7 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EMC85043.1 - 9e-05 22.4 0.0 0.017 15.1 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EMC85043.1 - 0.00022 21.2 0.2 0.047 13.7 0.1 2.7 2 2 0 2 2 2 2 RNA binding motif RL PF17797.1 EMC85043.1 - 0.039 13.9 0.0 5.2 7.1 0.0 2.6 2 1 0 2 2 2 0 RL domain Pkinase PF00069.25 EMC85044.1 - 1.3e-72 244.4 0.6 2e-69 233.9 0.0 2.7 3 0 0 3 3 3 2 Protein kinase domain cNMP_binding PF00027.29 EMC85044.1 - 3.8e-38 129.4 0.1 9e-20 70.5 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 EMC85044.1 - 3.7e-34 118.2 0.0 7e-33 114.0 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC85044.1 - 0.00059 19.3 0.0 0.00099 18.5 0.0 1.5 1 0 0 1 1 1 1 Kinase-like CASP_C PF08172.12 EMC85044.1 - 0.012 15.0 0.1 0.022 14.1 0.1 1.4 1 0 0 1 1 1 0 CASP C terminal ATG16 PF08614.11 EMC85044.1 - 0.016 15.4 5.4 0.034 14.4 5.4 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) UPF0242 PF06785.11 EMC85044.1 - 0.083 13.0 3.2 0.24 11.5 3.2 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Corona_S2 PF01601.16 EMC85044.1 - 0.11 11.0 0.7 0.2 10.1 0.7 1.3 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein APH PF01636.23 EMC85044.1 - 0.12 12.2 0.0 0.32 10.9 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3552 PF12072.8 EMC85044.1 - 0.15 11.4 5.7 0.32 10.4 5.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Antigen_Bd37 PF11641.8 EMC85044.1 - 0.16 11.5 0.0 0.16 11.5 0.0 2.0 2 0 0 2 2 2 0 Glycosylphosphatidylinositol-anchored merozoite surface protein DUF4407 PF14362.6 EMC85044.1 - 0.57 9.5 4.4 0.94 8.8 4.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PKcGMP_CC PF16808.5 EMC85044.1 - 2.8 7.9 7.7 5.6 6.9 2.1 2.7 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase SlyX PF04102.12 EMC85044.1 - 3.1 8.5 5.0 11 6.7 5.0 1.9 1 0 0 1 1 1 0 SlyX RasGEF PF00617.19 EMC85045.1 - 3.4e-52 177.2 1.7 3.6e-52 177.1 0.2 1.8 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EMC85045.1 - 3.7e-16 59.2 1.3 6.8e-16 58.4 0.1 2.0 2 1 0 2 2 2 1 RasGEF N-terminal motif Rib_hydrolayse PF02267.17 EMC85045.1 - 0.067 12.6 0.4 0.35 10.2 0.1 2.0 2 0 0 2 2 2 0 ADP-ribosyl cyclase LMP PF04778.12 EMC85045.1 - 0.55 10.1 4.5 0.28 11.1 0.3 2.3 3 0 0 3 3 3 0 LMP repeated region TGF_beta PF00019.20 EMC85046.1 - 6.8e-31 107.3 0.2 1.6e-30 106.2 0.2 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain FGF PF00167.18 EMC85047.1 - 1.1e-41 141.8 0.0 1.4e-41 141.5 0.0 1.1 1 0 0 1 1 1 1 Fibroblast growth factor Ant_C PF05586.11 EMC85048.1 - 7.1e-41 138.7 0.4 7.1e-41 138.7 0.4 1.8 2 0 0 2 2 2 1 Anthrax receptor C-terminus region Anth_Ig PF05587.13 EMC85048.1 - 5.6e-38 129.4 1.4 9.1e-38 128.7 0.7 1.7 2 0 0 2 2 2 1 Anthrax receptor extracellular domain VWA PF00092.28 EMC85048.1 - 1.3e-08 35.3 0.0 2e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EMC85048.1 - 0.016 15.8 0.1 0.12 13.1 0.0 2.4 3 0 0 3 3 3 0 von Willebrand factor type A domain LpxI_N PF17930.1 EMC85048.1 - 0.11 12.3 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 LpxI N-terminal domain HlyIII PF03006.20 EMC85050.1 - 2.1e-49 168.3 23.7 2.7e-49 167.9 23.7 1.1 1 0 0 1 1 1 1 Haemolysin-III related Presenilin PF01080.17 EMC85050.1 - 5.8 5.6 12.3 7.3 5.2 0.0 2.4 2 1 0 2 2 2 0 Presenilin DUF2070 PF09843.9 EMC85050.1 - 7.9 4.6 11.0 10 4.3 11.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Pkinase PF00069.25 EMC85051.1 - 1e-41 143.0 0.0 1e-41 143.0 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC85051.1 - 1.2e-24 87.0 0.0 1.2e-24 87.0 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC85051.1 - 2.9e-08 33.4 1.1 2e-07 30.6 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EMC85051.1 - 0.0062 16.5 7.7 0.13 12.2 0.1 3.2 2 2 1 3 3 3 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EMC85051.1 - 0.0065 15.3 0.0 0.014 14.2 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EMC85051.1 - 0.013 14.4 0.1 0.013 14.4 0.1 2.1 2 0 0 2 2 2 0 Haspin like kinase domain NTF2 PF02136.20 EMC85052.1 - 3.1e-33 114.9 0.1 5.1e-33 114.2 0.1 1.4 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 EMC85052.1 - 4.4e-14 52.0 0.1 8.5e-14 51.1 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMC85052.1 - 8.7e-06 25.8 0.0 2.1e-05 24.6 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif EGF PF00008.27 EMC85053.1 - 0.0021 18.3 3.1 0.0038 17.5 3.1 1.4 1 0 0 1 1 1 1 EGF-like domain Ycf70 PF17382.2 EMC85053.1 - 0.012 16.0 3.3 0.014 15.8 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized Ycf70-like PRIMA1 PF16101.5 EMC85053.1 - 0.037 14.1 0.1 0.082 12.9 0.1 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 DUF3377 PF11857.8 EMC85053.1 - 0.06 13.3 0.5 0.13 12.2 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) FtsL PF04999.13 EMC85053.1 - 0.061 13.3 0.2 0.11 12.5 0.2 1.4 1 0 0 1 1 1 0 Cell division protein FtsL ECSCR PF15820.5 EMC85053.1 - 0.068 13.0 0.4 0.068 13.0 0.4 2.0 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator TMEM154 PF15102.6 EMC85053.1 - 0.075 12.9 1.4 0.094 12.6 0.1 1.7 2 0 0 2 2 2 0 TMEM154 protein family EGF PF00008.27 EMC85054.1 - 0.00018 21.7 3.6 0.00038 20.7 3.6 1.6 1 0 0 1 1 1 1 EGF-like domain CD34_antigen PF06365.12 EMC85054.1 - 0.0062 16.2 0.8 0.0062 16.2 0.8 1.2 1 1 0 1 1 1 1 CD34/Podocalyxin family LMBR1 PF04791.16 EMC85054.1 - 0.055 12.4 0.4 0.068 12.1 0.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein THF_DHG_CYH_C PF02882.19 EMC85056.1 - 1.7e-61 206.2 3.1 2.3e-61 205.8 3.1 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 EMC85056.1 - 1e-37 128.9 0.2 1.6e-37 128.3 0.2 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain IL8 PF00048.20 EMC85057.1 - 8.2e-15 54.7 0.2 8.9e-15 54.6 0.2 1.0 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like IL8 PF00048.20 EMC85058.1 - 6.1e-18 64.7 0.6 7.6e-18 64.4 0.6 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Ig_J_chain PF15097.6 EMC85058.1 - 0.007 16.3 0.1 0.009 15.9 0.1 1.1 1 0 0 1 1 1 1 Immunoglobulin J chain IL8 PF00048.20 EMC85059.1 - 8.5e-16 57.9 0.2 1.1e-15 57.6 0.2 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like RA PF00788.23 EMC85060.1 - 4.9e-12 46.3 0.0 1.2e-11 45.0 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Nore1-SARAH PF16517.5 EMC85060.1 - 6.9e-11 41.9 4.4 6.9e-11 41.9 4.4 2.2 2 0 0 2 2 2 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain RecO_C PF02565.15 EMC85060.1 - 0.047 13.5 0.1 0.21 11.4 0.0 2.0 1 1 1 2 2 2 0 Recombination protein O C terminal TUG-UBL1 PF11470.8 EMC85060.1 - 0.066 13.4 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 TUG ubiquitin-like domain YusW PF14039.6 EMC85060.1 - 0.24 11.9 0.0 0.24 11.9 0.0 2.8 4 0 0 4 4 4 0 YusW-like protein Serum_albumin PF00273.20 EMC85061.1 - 2.4e-145 480.1 31.4 2.6e-54 183.7 8.4 3.1 3 0 0 3 3 3 3 Serum albumin family CYTL1 PF15153.6 EMC85061.1 - 0.083 12.8 3.4 0.093 12.7 0.2 2.8 3 0 0 3 3 3 0 Cytokine-like protein 1 VitD-bind_III PF09164.10 EMC85061.1 - 0.68 10.0 18.3 1.7 8.7 0.1 5.7 6 0 0 6 6 6 0 Vitamin D binding protein, domain III Ank_2 PF12796.7 EMC85062.1 - 2e-152 496.2 33.8 1.5e-19 70.3 0.7 12.5 3 3 9 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC85062.1 - 6.4e-126 409.3 17.3 1.9e-12 47.4 0.0 16.8 8 4 10 19 19 19 18 Ankyrin repeats (many copies) Ank PF00023.30 EMC85062.1 - 5e-116 374.5 54.5 5.3e-08 33.0 0.0 24.8 25 0 0 25 25 25 21 Ankyrin repeat Ank_3 PF13606.6 EMC85062.1 - 2.5e-106 334.6 32.4 7.3e-05 22.9 0.0 25.3 25 0 0 25 25 25 23 Ankyrin repeat Ank_5 PF13857.6 EMC85062.1 - 1.7e-96 315.0 44.1 2.2e-10 40.6 0.0 20.2 7 4 14 21 21 21 21 Ankyrin repeats (many copies) KH_1 PF00013.29 EMC85062.1 - 2.3e-15 56.2 2.9 7.7e-15 54.5 2.9 2.0 1 0 0 1 1 1 1 KH domain KH_4 PF13083.6 EMC85062.1 - 0.075 12.9 0.0 0.31 10.9 0.0 2.1 1 0 0 1 1 1 0 KH domain 60KD_IMP PF02096.20 EMC85063.1 - 1.7e-15 57.3 0.0 3.3e-15 56.4 0.0 1.4 1 1 0 1 1 1 1 60Kd inner membrane protein ATP-synt_A PF00119.20 EMC85063.1 - 0.016 15.1 0.4 0.022 14.7 0.4 1.2 1 0 0 1 1 1 0 ATP synthase A chain Pep_M12B_propep PF01562.19 EMC85064.1 - 4.9e-41 140.2 0.0 1e-40 139.2 0.0 1.6 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_spacer1 PF05986.14 EMC85064.1 - 1.8e-31 108.6 0.0 3.6e-31 107.5 0.0 1.6 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 EMC85064.1 - 3e-21 75.4 59.0 7.2e-10 38.9 6.2 6.1 6 0 0 6 6 6 4 Thrombospondin type 1 domain ADAM_CR_2 PF17771.1 EMC85064.1 - 6.3e-21 74.7 20.1 5.8e-20 71.6 7.0 5.0 5 1 0 5 5 3 2 ADAM cysteine-rich domain Reprolysin PF01421.19 EMC85064.1 - 5.9e-19 68.8 0.0 1.2e-18 67.7 0.0 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.6 EMC85064.1 - 2.5e-14 53.9 0.8 6.6e-14 52.5 0.8 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EMC85064.1 - 1.4e-09 38.5 1.5 1.8e-09 38.1 0.4 1.8 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EMC85064.1 - 2e-09 37.7 0.4 4e-09 36.6 0.4 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EMC85064.1 - 1.1e-06 28.5 0.2 2.3e-06 27.4 0.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like PLAC PF08686.11 EMC85064.1 - 3.6e-05 24.4 5.8 0.00021 22.0 5.8 2.5 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain Peptidase_M10 PF00413.24 EMC85064.1 - 0.0019 18.1 0.4 0.0039 17.0 0.2 1.7 2 0 0 2 2 2 1 Matrixin DUF4953 PF16313.5 EMC85064.1 - 0.1 11.8 0.4 0.18 11.0 0.4 1.3 1 0 0 1 1 1 0 Met-zincin EF-hand_6 PF13405.6 EMC85067.1 - 5.2e-14 50.9 0.3 4e-05 23.2 0.1 3.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 EMC85067.1 - 1.9e-13 50.6 0.8 0.0041 17.5 0.2 3.0 2 1 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EMC85067.1 - 3.9e-13 47.9 2.4 8.5e-05 21.8 0.0 4.0 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.6 EMC85067.1 - 2.1e-10 39.6 4.5 0.0011 18.3 0.1 4.1 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 EMC85067.1 - 2e-09 37.1 2.5 3.3e-05 23.7 0.2 3.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_4 PF12763.7 EMC85067.1 - 0.0017 18.3 0.0 0.015 15.3 0.0 2.1 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EMC85067.1 - 0.015 15.7 0.5 5.2 7.4 0.0 2.4 1 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 EMC85067.1 - 0.035 14.0 0.0 0.13 12.2 0.0 1.9 2 0 0 2 2 2 0 EF hand Dockerin_1 PF00404.18 EMC85067.1 - 0.1 12.8 0.0 12 6.1 0.0 2.9 3 0 0 3 3 3 0 Dockerin type I domain EF-hand_9 PF14658.6 EMC85067.1 - 0.11 12.9 0.1 4.9 7.6 0.0 2.8 2 1 1 3 3 3 0 EF-hand domain 7tm_4 PF13853.6 EMC85069.1 - 7.9e-11 42.2 0.0 8.3e-11 42.1 0.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC85069.1 - 0.032 13.5 0.1 0.034 13.5 0.1 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) SDF PF00375.18 EMC85070.1 - 3e-134 447.9 32.0 3.5e-134 447.7 32.0 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family MT PF12777.7 EMC85070.1 - 0.013 14.6 0.1 0.021 13.9 0.1 1.3 1 0 0 1 1 1 0 Microtubule-binding stalk of dynein motor DUF1270 PF06900.11 EMC85070.1 - 0.48 10.8 5.3 5.6 7.4 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1270) Nipped-B_C PF12830.7 EMC85072.1 - 1.1e-67 227.7 11.2 1.8e-67 227.0 1.2 4.5 4 0 0 4 4 4 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 EMC85072.1 - 3e-13 49.8 2.9 4.1e-11 43.0 0.2 3.6 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion HEAT_2 PF13646.6 EMC85072.1 - 3.2e-06 27.4 0.0 7.4 7.0 0.0 5.5 5 1 1 6 6 6 3 HEAT repeats HEAT_EZ PF13513.6 EMC85072.1 - 4.1e-05 24.0 0.0 4.4 7.9 0.0 5.4 5 0 0 5 5 5 1 HEAT-like repeat Cnd1 PF12717.7 EMC85072.1 - 0.00015 21.8 10.1 0.082 12.9 1.2 5.4 3 2 2 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EMC85072.1 - 0.00031 20.8 5.0 0.25 11.7 0.0 6.7 7 0 0 7 7 7 1 HEAT repeat Cnd3 PF12719.7 EMC85072.1 - 0.0021 17.3 7.6 0.013 14.7 0.0 4.2 4 0 0 4 4 4 1 Nuclear condensing complex subunits, C-term domain RIX1 PF08167.12 EMC85072.1 - 0.052 13.3 0.1 1.3 8.7 0.0 3.6 2 0 0 2 2 2 0 rRNA processing/ribosome biogenesis WD40 PF00400.32 EMC85073.1 - 6e-18 64.9 13.9 0.0013 19.5 0.0 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC85073.1 - 2.2e-08 34.3 0.0 0.16 12.3 0.0 5.8 3 1 4 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMC85073.1 - 3e-05 23.2 0.6 0.011 14.8 0.2 3.4 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein TGF_beta PF00019.20 EMC85074.1 - 3.3e-12 47.3 0.5 5.3e-12 46.6 0.5 1.3 1 0 0 1 1 1 1 Transforming growth factor beta like domain Laminin_G_1 PF00054.23 EMC85075.1 - 1e-82 274.9 0.0 1.7e-26 92.9 0.0 3.3 3 0 0 3 3 3 3 Laminin G domain Laminin_G_2 PF02210.24 EMC85075.1 - 3.1e-82 273.4 0.1 3.5e-28 98.7 0.1 3.4 3 0 0 3 3 3 3 Laminin G domain fn3 PF00041.21 EMC85075.1 - 3.6e-24 84.9 0.2 2.9e-13 49.9 0.2 2.7 2 0 0 2 2 2 2 Fibronectin type III domain EGF PF00008.27 EMC85075.1 - 1.2e-10 41.4 34.5 1e-07 32.1 7.1 3.6 3 0 0 3 3 3 2 EGF-like domain Laminin_G_3 PF13385.6 EMC85075.1 - 1.8e-10 41.2 0.0 0.036 14.2 0.0 3.4 3 0 0 3 3 3 3 Concanavalin A-like lectin/glucanases superfamily Stirrup PF09061.6 EMC85075.1 - 6.3e-07 29.5 0.1 0.014 15.6 0.0 3.4 3 0 0 3 3 3 2 Stirrup hEGF PF12661.7 EMC85075.1 - 6.9e-07 29.7 22.7 0.00019 21.9 3.8 4.0 3 0 0 3 3 3 2 Human growth factor-like EGF Pur_ac_phosph_N PF16656.5 EMC85075.1 - 3.3e-06 27.6 0.1 0.041 14.5 0.0 2.9 3 0 0 3 3 2 2 Purple acid Phosphatase, N-terminal domain fn3_4 PF16794.5 EMC85075.1 - 0.00062 19.7 0.0 0.18 11.8 0.0 2.4 2 0 0 2 2 2 1 Fibronectin-III type domain Bile_Hydr_Trans PF04775.14 EMC85075.1 - 0.079 13.0 0.0 2.6 8.1 0.0 2.4 2 0 0 2 2 2 0 Acyl-CoA thioester hydrolase/BAAT N-terminal region EGF_CA PF07645.15 EMC85075.1 - 6.2 7.1 37.8 0.58 10.4 6.1 3.5 3 0 0 3 3 3 0 Calcium-binding EGF domain LIFR_D2 PF17971.1 EMC85076.1 - 4.2e-54 181.6 2.0 4.2e-54 181.6 2.0 3.3 2 1 0 2 2 2 1 Leukemia inhibitory factor receptor D2 domain fn3 PF00041.21 EMC85076.1 - 2.3e-19 69.5 3.0 3.4e-05 24.1 0.0 6.3 5 2 0 5 5 5 4 Fibronectin type III domain IL6Ra-bind PF09240.10 EMC85076.1 - 9.4e-09 35.6 0.7 0.0041 17.5 0.0 3.2 2 0 0 2 2 2 2 Interleukin-6 receptor alpha chain, binding EpoR_lig-bind PF09067.10 EMC85076.1 - 1.3e-05 25.4 0.6 0.0095 16.1 0.1 2.6 2 0 0 2 2 2 2 Erythropoietin receptor, ligand binding LIFR_N PF18207.1 EMC85076.1 - 2.1e-05 24.8 0.7 2.1e-05 24.8 0.7 3.3 3 0 0 3 3 3 1 Leukemia inhibitory factor receptor N-terminal domain Pur_ac_phosph_N PF16656.5 EMC85076.1 - 0.00046 20.7 2.6 0.0011 19.4 0.0 3.0 4 0 0 4 4 4 1 Purple acid Phosphatase, N-terminal domain fn3 PF00041.21 EMC85077.1 - 3.6e-17 62.5 7.4 1.1e-05 25.7 0.2 5.1 5 0 0 5 5 5 4 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 EMC85077.1 - 0.00015 22.3 2.4 0.0059 17.2 0.2 2.9 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain RICTOR_N PF14664.6 EMC85078.1 - 3.4e-109 365.3 1.6 7.3e-109 364.2 1.6 1.6 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_phospho PF14665.6 EMC85078.1 - 4.9e-55 184.5 2.7 4.9e-55 184.5 2.7 2.1 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, phosphorylation-site RasGEF_N_2 PF14663.6 EMC85078.1 - 1.2e-36 125.4 0.5 1.2e-36 125.4 0.5 3.3 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_M PF14666.6 EMC85078.1 - 1.4e-32 111.6 4.5 1.5e-31 108.2 0.8 4.2 5 0 0 5 5 5 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.6 EMC85078.1 - 5.6e-32 109.8 1.8 1.3e-29 102.2 0.2 4.3 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 HEAT_EZ PF13513.6 EMC85078.1 - 0.0075 16.8 2.6 0.79 10.3 0.1 3.9 3 0 0 3 3 3 1 HEAT-like repeat 7TM_GPCR_Srbc PF10316.9 EMC85078.1 - 0.07 12.6 3.1 1.9 7.9 0.0 2.6 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srbc hSH3 PF14603.6 EMC85079.1 - 8.8e-35 119.0 18.0 6.6e-25 87.4 0.0 6.1 7 0 0 7 7 7 2 Helically-extended SH3 domain SH3_2 PF07653.17 EMC85079.1 - 2.9e-06 26.9 0.1 6.6e-06 25.7 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC85079.1 - 0.0037 16.9 0.3 0.9 9.2 0.0 2.5 2 0 0 2 2 2 2 SH3 domain PID PF00640.23 EMC85080.1 - 3.5e-09 36.8 0.1 5.4e-09 36.2 0.1 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Presenilin PF01080.17 EMC85081.1 - 3.2 6.4 34.4 3.8 6.2 34.4 1.0 1 0 0 1 1 1 0 Presenilin Mpp10 PF04006.12 EMC85081.1 - 4.5 5.6 51.8 4.9 5.5 51.8 1.0 1 0 0 1 1 1 0 Mpp10 protein DUF2052 PF09747.9 EMC85081.1 - 4.5 7.4 43.1 7.3 6.7 43.1 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) TP53IP5 PF15331.6 EMC85081.1 - 6.8 6.8 33.7 8.4 6.5 33.7 1.0 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Trypan_PARP PF05887.11 EMC85081.1 - 9.3 6.2 45.7 3 7.8 26.6 2.0 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) 7tm_1 PF00001.21 EMC85082.1 - 1e-38 133.2 11.9 1.3e-38 132.9 11.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC85082.1 - 6.2e-10 39.2 15.4 9.2e-10 38.6 15.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx NdhL PF10716.9 EMC85082.1 - 0.0023 17.8 0.9 0.011 15.6 0.0 2.5 2 0 0 2 2 2 1 NADH dehydrogenase transmembrane subunit 7TM_GPCR_Sru PF10322.9 EMC85082.1 - 1.1 8.5 16.1 4.8 6.4 16.4 2.0 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Sru RecO_N_2 PF13114.6 EMC85083.1 - 0.0062 16.2 0.0 0.017 14.9 0.0 1.7 2 0 0 2 2 2 1 RecO N terminal TPR_2 PF07719.17 EMC85084.1 - 1.7e-09 37.1 0.0 0.00053 19.9 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMC85084.1 - 8.2e-07 29.6 0.1 0.078 13.6 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 EMC85084.1 - 2.1e-05 24.6 1.0 0.0099 16.0 0.1 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMC85084.1 - 4.4e-05 24.0 1.4 0.9 10.5 0.2 3.5 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 EMC85084.1 - 6.5e-05 22.6 0.0 0.29 11.0 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EMC85084.1 - 0.00011 21.8 0.0 0.0028 17.3 0.0 2.5 2 1 0 2 2 2 1 TPR repeat TPR_19 PF14559.6 EMC85084.1 - 0.00013 22.4 0.0 0.017 15.6 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 EMC85084.1 - 0.00029 21.0 0.0 0.11 12.9 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat ChAPs PF09295.10 EMC85084.1 - 0.0022 17.0 0.1 0.0032 16.5 0.1 1.3 1 1 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) DUF3164 PF11363.8 EMC85084.1 - 0.065 12.8 3.5 2.2 7.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3164) ANAPC3 PF12895.7 EMC85084.1 - 0.088 13.0 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Gp-FAR-1 PF05823.12 EMC85084.1 - 0.28 11.5 3.3 2.1 8.7 0.3 2.2 2 0 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Pkinase PF00069.25 EMC85085.1 - 5.2e-75 252.2 0.0 7.1e-75 251.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC85085.1 - 7.6e-42 143.4 0.0 1.1e-41 142.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 EMC85085.1 - 5.3e-13 49.5 0.0 1.9e-12 47.7 0.0 2.0 2 0 0 2 2 2 1 Adenylate sensor of SNF1-like protein kinase Kinase-like PF14531.6 EMC85085.1 - 1.9e-05 24.2 0.0 3.2e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EMC85085.1 - 0.0026 17.4 0.2 0.0048 16.5 0.2 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 EMC85085.1 - 0.0043 16.4 0.1 0.009 15.4 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMC85085.1 - 0.063 13.2 0.2 0.17 11.8 0.2 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EMC85085.1 - 0.1 11.5 0.1 0.15 11.0 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain F-box-like PF12937.7 EMC85086.1 - 1.8e-06 27.8 0.7 7.9e-06 25.7 1.1 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EMC85086.1 - 5.8e-06 26.0 0.5 2.3e-05 24.2 0.1 2.1 2 0 0 2 2 2 1 F-box domain DUF5561 PF17716.1 EMC85087.1 - 2.8e-117 390.5 2.1 3.3e-117 390.3 2.1 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5561) CoA_trans PF01144.23 EMC85088.1 - 4.3e-123 408.7 1.2 8.8e-75 250.8 0.3 2.0 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.6 EMC85088.1 - 0.0029 17.6 0.1 0.0058 16.6 0.1 1.4 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain RVT_1 PF00078.27 EMC85089.1 - 0.0039 16.7 0.0 0.013 15.0 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) PI-PLC-X PF00388.19 EMC85090.1 - 0.00055 19.6 0.0 0.00088 18.9 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain MACPF PF01823.19 EMC85091.1 - 1.6e-43 149.3 2.6 3.1e-43 148.3 1.2 1.9 2 0 0 2 2 2 1 MAC/Perforin domain Sushi PF00084.20 EMC85091.1 - 1.8e-17 63.7 5.3 2.1e-09 37.8 1.1 4.4 4 1 0 4 4 4 2 Sushi repeat (SCR repeat) TSP_1 PF00090.19 EMC85091.1 - 1.1e-12 47.9 29.2 2.3e-07 30.9 7.9 5.9 5 0 0 5 5 5 3 Thrombospondin type 1 domain Ldl_recept_a PF00057.18 EMC85091.1 - 4.9e-11 42.6 14.1 4.9e-11 42.6 14.1 4.3 3 0 0 3 3 3 1 Low-density lipoprotein receptor domain class A MACPF PF01823.19 EMC85092.1 - 3.1e-38 132.0 1.6 4.8e-38 131.4 0.4 1.8 1 1 1 2 2 2 1 MAC/Perforin domain Kazal_3 PF18434.1 EMC85092.1 - 6.2e-20 70.7 7.2 6.2e-20 70.7 7.2 4.1 3 0 0 3 3 3 2 Kazal-type serine protease inhibitor domain Sushi PF00084.20 EMC85092.1 - 2.5e-18 66.4 7.4 1.7e-11 44.5 0.5 3.9 3 0 0 3 3 3 2 Sushi repeat (SCR repeat) TSP_1 PF00090.19 EMC85092.1 - 3.6e-08 33.5 23.5 1.4e-05 25.2 3.6 5.2 5 0 0 5 5 5 2 Thrombospondin type 1 domain Ldl_recept_a PF00057.18 EMC85092.1 - 1.8e-06 28.1 15.0 1.8e-06 28.1 15.0 4.2 3 0 0 3 3 3 1 Low-density lipoprotein receptor domain class A Ribosomal_L37e PF01907.19 EMC85093.1 - 4.2e-27 94.1 15.1 7.7e-27 93.2 15.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.7 EMC85093.1 - 0.0064 16.5 1.7 0.01 15.8 1.7 1.3 1 0 0 1 1 1 1 Double zinc ribbon HypA PF01155.19 EMC85093.1 - 0.23 11.5 1.4 0.32 11.0 1.4 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FeS PF04060.13 EMC85093.1 - 0.53 10.0 4.0 0.57 9.9 0.7 2.1 2 0 0 2 2 2 0 Putative Fe-S cluster Ras PF00071.22 EMC85096.1 - 1.6e-58 196.9 0.1 1.9e-58 196.6 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC85096.1 - 2.3e-32 111.7 0.0 3.8e-32 111.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC85096.1 - 2.5e-13 49.9 0.1 3e-13 49.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC85096.1 - 2.4e-07 30.8 0.0 4.2e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC85096.1 - 2.6e-06 27.5 0.2 0.0033 17.3 0.1 2.2 1 1 1 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EMC85096.1 - 3.5e-06 26.5 0.0 4.5e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EMC85096.1 - 1.2e-05 25.0 0.0 0.00077 19.0 0.0 2.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain cobW PF02492.19 EMC85096.1 - 0.0026 17.4 0.0 0.0096 15.5 0.0 1.8 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.18 EMC85096.1 - 0.0028 17.0 0.6 0.021 14.1 0.1 2.1 2 1 0 2 2 2 1 Septin ATP_bind_1 PF03029.17 EMC85096.1 - 0.0031 17.3 0.3 0.084 12.6 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 EMC85096.1 - 0.0051 17.1 0.0 0.014 15.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 EMC85096.1 - 0.0053 16.5 0.0 0.12 12.1 0.1 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 EMC85096.1 - 0.012 15.2 0.1 0.019 14.5 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EMC85096.1 - 0.015 15.0 0.1 0.027 14.2 0.0 1.6 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.10 EMC85096.1 - 0.016 14.7 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 EMC85096.1 - 0.019 15.3 0.1 0.036 14.4 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain NTPase_1 PF03266.15 EMC85096.1 - 0.023 14.6 0.0 0.042 13.8 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_5 PF07728.14 EMC85096.1 - 0.025 14.6 0.0 0.041 13.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) G-alpha PF00503.20 EMC85096.1 - 0.04 13.1 1.2 0.3 10.2 0.2 2.2 2 1 1 3 3 3 0 G-protein alpha subunit TniB PF05621.11 EMC85096.1 - 0.069 12.6 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein ATPase_2 PF01637.18 EMC85096.1 - 0.07 13.0 0.7 0.11 12.3 0.1 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 EMC85096.1 - 0.087 12.0 0.1 0.15 11.3 0.1 1.4 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 EMC85096.1 - 0.089 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 EMC85096.1 - 0.18 12.4 0.1 0.5 10.9 0.0 1.7 2 0 0 2 2 2 0 ABC transporter Ribophorin_I PF04597.14 EMC85097.1 - 1.3e-137 459.6 8.0 1.6e-137 459.3 8.0 1.1 1 0 0 1 1 1 1 Ribophorin I DNA_repr_REX1B PF14966.6 EMC85097.1 - 0.0019 18.8 1.0 0.0037 17.9 0.4 1.8 2 0 0 2 2 2 1 DNA repair REX1-B DUF2310 PF10071.9 EMC85097.1 - 0.58 9.4 2.2 0.89 8.8 0.1 2.0 2 0 0 2 2 2 0 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310) GATA PF00320.27 EMC85098.1 - 2.6e-30 103.7 19.2 3.9e-15 55.1 6.3 2.4 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 EMC85098.1 - 0.00014 21.3 10.9 0.025 14.1 0.5 2.3 2 0 0 2 2 2 2 TFIIB zinc-binding DUF2387 PF09526.10 EMC85098.1 - 0.014 15.5 7.5 1.7 8.8 1.0 3.2 1 1 2 3 3 3 0 Probable metal-binding protein (DUF2387) TDP43_N PF18694.1 EMC85098.1 - 0.052 13.4 0.2 2.2 8.2 0.0 2.2 2 0 0 2 2 2 0 Transactive response DNA-binding protein N-terminal domain Zn-ribbon_8 PF09723.10 EMC85098.1 - 0.22 11.7 7.9 1.5 9.0 0.6 3.1 2 1 2 4 4 4 0 Zinc ribbon domain Auto_anti-p27 PF06677.12 EMC85098.1 - 0.33 11.2 8.4 1.3 9.3 0.3 2.5 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Prim_Zn_Ribbon PF08273.12 EMC85098.1 - 1.5 9.2 13.6 0.15 12.3 1.9 3.0 2 1 0 2 2 2 0 Zinc-binding domain of primase-helicase eIF-5_eIF-2B PF01873.17 EMC85098.1 - 2.6 8.0 8.8 10 6.0 0.2 2.4 2 0 0 2 2 2 0 Domain found in IF2B/IF5 DZR PF12773.7 EMC85098.1 - 7.1 6.7 16.4 4.4 7.4 2.1 3.3 1 1 2 3 3 3 0 Double zinc ribbon DnaJ PF00226.31 EMC85099.1 - 6.5e-26 90.2 2.8 7e-26 90.1 2.8 1.0 1 0 0 1 1 1 1 DnaJ domain GTP_EFTU_D2 PF03144.25 EMC85100.1 - 3.8e-08 33.6 0.1 8.5e-08 32.5 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU PF00009.27 EMC85100.1 - 4.3e-08 32.9 0.0 5.1e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain cobW PF02492.19 EMC85100.1 - 0.00015 21.4 0.7 0.00024 20.7 0.7 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain FliS_cochap PF16522.5 EMC85100.1 - 0.049 13.6 0.3 0.21 11.5 0.2 1.9 2 0 0 2 2 2 0 Flagellar FLiS export co-chaperone, HP1076 Gtr1_RagA PF04670.12 EMC85100.1 - 0.1 12.0 0.1 0.19 11.1 0.1 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EMC85100.1 - 0.15 12.0 0.1 0.39 10.6 0.1 1.7 2 0 0 2 2 2 0 RsgA GTPase TIP49 PF06068.13 EMC85101.1 - 4.2e-173 575.5 0.2 5.2e-173 575.2 0.2 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EMC85101.1 - 2.2e-26 91.7 0.1 6.4e-26 90.3 0.1 1.9 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 EMC85101.1 - 5.6e-13 49.5 0.5 2.8e-08 34.2 0.0 3.2 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EMC85101.1 - 1.2e-11 44.6 0.1 3.4e-08 33.4 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EMC85101.1 - 3.1e-06 27.5 0.1 0.12 12.7 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EMC85101.1 - 3.8e-05 24.1 0.0 0.00031 21.2 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EMC85101.1 - 5.8e-05 23.1 0.1 0.0041 17.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EMC85101.1 - 0.00016 21.3 0.0 0.00086 18.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 EMC85101.1 - 0.00018 21.3 0.1 0.2 11.3 0.0 2.6 2 1 0 2 2 2 2 Sigma-54 interaction domain Mg_chelatase PF01078.21 EMC85101.1 - 0.00073 19.0 0.2 0.037 13.4 0.1 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 EMC85101.1 - 0.001 19.4 1.5 0.029 14.7 1.5 2.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMC85101.1 - 0.0015 19.0 0.0 0.011 16.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EMC85101.1 - 0.0021 17.8 0.0 0.0045 16.7 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_28 PF13521.6 EMC85101.1 - 0.0025 18.1 0.1 0.0047 17.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 EMC85101.1 - 0.0031 16.9 0.0 0.0065 15.8 0.0 1.5 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain ResIII PF04851.15 EMC85101.1 - 0.0088 16.1 0.0 0.35 10.9 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_33 PF13671.6 EMC85101.1 - 0.011 16.0 0.0 0.031 14.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EMC85101.1 - 0.011 15.1 0.2 0.032 13.5 0.1 1.8 2 0 0 2 2 2 0 Zeta toxin PhoH PF02562.16 EMC85101.1 - 0.011 15.2 0.1 0.035 13.6 0.1 1.8 1 0 0 1 1 1 0 PhoH-like protein NACHT PF05729.12 EMC85101.1 - 0.013 15.4 0.0 0.027 14.4 0.0 1.5 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.17 EMC85101.1 - 0.015 15.2 0.0 0.035 14.1 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EMC85101.1 - 0.017 14.7 0.1 0.062 12.8 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region Parvo_NS1 PF01057.17 EMC85101.1 - 0.019 14.1 0.0 0.039 13.0 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_11 PF13086.6 EMC85101.1 - 0.019 14.8 0.0 0.043 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EMC85101.1 - 0.039 13.7 0.2 0.81 9.4 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EMC85101.1 - 0.053 13.6 0.0 8.6 6.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EMC85101.1 - 0.057 12.8 1.5 0.2 11.0 0.0 2.4 3 0 0 3 3 3 0 KaiC DNA_pol3_delta2 PF13177.6 EMC85101.1 - 0.07 12.9 0.0 1.9 8.3 0.0 2.2 2 1 0 2 2 2 0 DNA polymerase III, delta subunit DUF2075 PF09848.9 EMC85101.1 - 0.073 12.3 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.22 EMC85101.1 - 0.1 13.0 0.0 0.25 11.7 0.0 1.7 1 0 0 1 1 1 0 RNA helicase SecY PF00344.20 EMC85102.1 - 7.1e-77 258.7 12.0 9.5e-77 258.3 12.0 1.2 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 EMC85102.1 - 8.2e-19 67.2 0.2 2.4e-18 65.7 0.2 1.9 1 0 0 1 1 1 1 Plug domain of Sec61p YlaH PF14036.6 EMC85102.1 - 0.11 12.8 3.3 1.9 8.8 0.2 3.2 3 0 0 3 3 3 0 YlaH-like protein DUF2975 PF11188.8 EMC85102.1 - 0.25 11.2 9.1 0.065 13.1 0.7 3.8 2 1 2 4 4 4 0 Protein of unknown function (DUF2975) Kelch_1 PF01344.25 EMC85103.1 - 2.9e-30 103.6 9.8 6.4e-12 44.9 0.0 5.0 5 1 0 5 5 5 4 Kelch motif BACK PF07707.15 EMC85103.1 - 3.8e-29 100.8 2.7 3.8e-29 100.8 2.7 3.0 3 0 0 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.31 EMC85103.1 - 3.5e-23 82.0 1.4 3.5e-23 82.0 1.4 1.8 2 0 0 2 2 2 1 BTB/POZ domain Kelch_6 PF13964.6 EMC85103.1 - 2.9e-22 78.1 2.7 3.2e-09 36.8 0.0 5.0 3 1 1 4 4 4 3 Kelch motif Kelch_2 PF07646.15 EMC85103.1 - 1.3e-13 50.3 2.9 5.8e-06 26.1 0.0 4.9 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 EMC85103.1 - 3.9e-10 39.5 0.7 0.00011 22.1 0.0 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 EMC85103.1 - 5.4e-10 39.3 2.0 0.0028 17.9 0.0 4.2 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_4 PF13418.6 EMC85103.1 - 1.8e-09 37.4 6.1 0.00021 21.2 0.0 5.1 5 1 0 5 5 5 3 Galactose oxidase, central domain DUF3342 PF11822.8 EMC85103.1 - 0.00027 21.1 1.4 0.0027 17.9 0.2 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF3342) BTB PF00651.31 EMC85104.1 - 1.2e-43 147.8 2.7 1.2e-20 73.7 0.1 3.4 2 1 1 3 3 3 3 BTB/POZ domain Ank_5 PF13857.6 EMC85104.1 - 1.9e-07 31.2 0.1 6.4e-07 29.5 0.1 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC85104.1 - 1.9e-07 31.5 0.0 1.8e-06 28.4 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC85104.1 - 1.7e-06 28.4 0.2 1.2e-05 25.8 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) DUF3342 PF11822.8 EMC85104.1 - 1.5e-05 25.1 0.6 0.022 15.0 0.1 3.6 2 1 1 3 3 3 1 Domain of unknown function (DUF3342) Ank_3 PF13606.6 EMC85104.1 - 5.2e-05 23.3 0.4 0.00084 19.6 0.0 3.2 4 0 0 4 4 3 1 Ankyrin repeat BACK PF07707.15 EMC85104.1 - 0.0011 19.1 0.2 0.0035 17.4 0.2 1.9 1 0 0 1 1 1 1 BTB And C-terminal Kelch Ank PF00023.30 EMC85104.1 - 0.0012 19.1 0.0 0.0041 17.5 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeat P4Ha_N PF08336.11 EMC85104.1 - 0.031 14.3 1.6 0.091 12.8 0.3 2.3 3 0 0 3 3 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Orn_Arg_deC_N PF02784.16 EMC85104.1 - 0.15 11.4 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain IFT20 PF14931.6 EMC85104.1 - 0.47 10.6 4.7 0.4 10.8 2.5 2.0 2 1 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 CD34_antigen PF06365.12 EMC85105.1 - 1.5e-80 269.7 0.0 2.1e-80 269.2 0.0 1.2 1 0 0 1 1 1 1 CD34/Podocalyxin family Shisa PF13908.6 EMC85105.1 - 0.12 12.6 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Glycophorin_A PF01102.18 EMC85105.1 - 0.13 12.5 0.2 0.39 11.0 0.0 1.8 2 0 0 2 2 2 0 Glycophorin A PMP1_2 PF08114.11 EMC85105.1 - 0.23 11.2 2.8 0.43 10.3 2.8 1.4 1 0 0 1 1 1 0 ATPase proteolipid family MCM PF00493.23 EMC85106.1 - 1.2e-98 328.6 0.0 1.9e-98 328.0 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EMC85106.1 - 8.2e-37 125.9 0.1 1.7e-36 124.9 0.1 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EMC85106.1 - 2.6e-29 101.4 1.7 6.5e-29 100.2 1.7 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EMC85106.1 - 2.7e-17 63.2 0.7 1.2e-16 61.2 0.7 2.1 1 0 0 1 1 1 1 MCM N-terminal domain MCM2_N PF12619.8 EMC85106.1 - 5e-16 59.4 17.6 5e-16 59.4 17.6 2.2 3 0 0 3 3 3 1 Mini-chromosome maintenance protein 2 Mg_chelatase PF01078.21 EMC85106.1 - 1.3e-08 34.5 0.0 5.3e-07 29.2 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EMC85106.1 - 4.1e-07 29.9 0.0 3.1e-05 23.8 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EMC85106.1 - 9e-07 29.0 0.0 2.6e-06 27.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_2 PF17863.1 EMC85106.1 - 0.00097 18.9 0.4 0.004 17.0 0.1 2.2 2 0 0 2 2 1 1 AAA lid domain Sigma54_activat PF00158.26 EMC85106.1 - 0.003 17.3 0.1 1.2 8.8 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA PF00004.29 EMC85106.1 - 0.0031 17.9 0.0 0.0091 16.4 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 EMC85106.1 - 0.011 15.8 0.0 0.024 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Sigma54_activ_2 PF14532.6 EMC85106.1 - 0.027 14.6 0.2 0.17 12.0 0.0 2.3 3 0 0 3 3 3 0 Sigma-54 interaction domain Plexin_cytopl PF08337.12 EMC85107.1 - 1.6e-254 845.8 5.2 1.9e-254 845.5 5.2 1.1 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Sema PF01403.19 EMC85107.1 - 3.2e-71 240.4 0.0 4.9e-71 239.8 0.0 1.2 1 0 0 1 1 1 1 Sema domain TIG PF01833.24 EMC85107.1 - 2.4e-45 152.5 12.1 7.5e-13 48.4 0.1 6.0 6 0 0 6 6 6 4 IPT/TIG domain PSI PF01437.25 EMC85107.1 - 4.5e-21 75.1 53.4 3.3e-09 37.1 12.4 3.7 3 0 0 3 3 3 3 Plexin repeat TIG_plexin PF17960.1 EMC85107.1 - 2.5e-16 59.5 6.3 8.5e-11 41.7 0.1 5.6 5 0 0 5 5 5 2 TIG domain TIG_2 PF18020.1 EMC85107.1 - 6.8e-16 58.7 0.0 2.4e-15 56.9 0.0 2.0 1 0 0 1 1 1 1 TIG domain found in plexin YcbB PF08664.10 EMC85107.1 - 0.12 12.4 0.8 0.33 11.0 0.8 1.6 1 0 0 1 1 1 0 YcbB domain PSI_integrin PF17205.3 EMC85107.1 - 0.72 9.6 46.8 0.054 13.3 12.2 3.7 3 0 0 3 3 3 0 Integrin plexin domain Pyr_redox_2 PF07992.14 EMC85108.1 - 3e-50 171.1 0.1 4.1e-50 170.7 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EMC85108.1 - 1.1e-28 99.7 0.0 2.4e-28 98.6 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Glutaredoxin PF00462.24 EMC85108.1 - 1.8e-18 66.5 1.7 2.8e-18 65.9 0.1 2.3 3 0 0 3 3 2 1 Glutaredoxin Pyr_redox PF00070.27 EMC85108.1 - 2.2e-16 60.1 2.2 1.5e-13 51.1 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMC85108.1 - 1.9e-13 50.3 0.7 2.2e-09 37.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMC85108.1 - 5.6e-07 29.0 0.1 2.5e-06 26.8 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain AlaDh_PNT_C PF01262.21 EMC85108.1 - 0.0001 21.7 0.2 0.044 13.1 0.0 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EMC85108.1 - 0.00097 17.9 0.1 0.002 16.9 0.1 1.5 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 EMC85108.1 - 0.0016 17.8 0.7 0.0053 16.0 0.1 2.0 2 0 0 2 2 2 1 Thi4 family Thioredoxin_3 PF13192.6 EMC85108.1 - 0.0024 17.9 0.0 0.0065 16.5 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin domain FAD_oxidored PF12831.7 EMC85108.1 - 0.0033 16.8 0.0 0.0051 16.2 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DUF836 PF05768.14 EMC85108.1 - 0.0073 16.7 0.0 0.016 15.6 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) DAO PF01266.24 EMC85108.1 - 0.026 14.1 0.1 0.054 13.1 0.1 1.7 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 EMC85108.1 - 0.052 12.6 2.1 0.18 10.8 2.1 1.9 1 1 0 1 1 1 0 Glucose inhibited division protein A Thioredoxin_2 PF13098.6 EMC85108.1 - 0.11 13.0 0.0 0.27 11.7 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain NAD_binding_8 PF13450.6 EMC85108.1 - 0.19 12.0 6.8 0.12 12.6 0.6 2.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EMC85108.1 - 5.2 6.2 4.9 1.5 8.0 0.2 2.0 2 0 0 2 2 2 0 FAD binding domain Sulfotransfer_2 PF03567.14 EMC85109.1 - 7.7e-70 235.7 4.1 9.1e-70 235.4 4.1 1.1 1 0 0 1 1 1 1 Sulfotransferase family DUF4543 PF15076.6 EMC85109.1 - 0.072 13.2 0.7 0.14 12.3 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4543) MgtE PF01769.16 EMC85110.1 - 1.8e-49 167.2 29.1 1.7e-28 99.5 4.0 3.3 4 0 0 4 4 4 2 Divalent cation transporter zf-H2C2_2 PF13465.6 EMC85112.1 - 0.00031 21.0 0.7 0.00031 21.0 0.7 2.2 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.26 EMC85112.1 - 0.0023 18.3 5.7 0.0023 18.3 5.7 2.0 2 0 0 2 2 2 1 Zinc finger, C2H2 type DUF3512 PF12024.8 EMC85112.1 - 0.12 11.8 1.9 0.22 10.9 1.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3512) FOXP-CC PF16159.5 EMC85112.1 - 0.14 12.8 8.6 0.17 12.6 0.2 2.9 1 1 1 2 2 2 0 FOXP coiled-coil domain DUF4200 PF13863.6 EMC85113.1 - 2.2e-26 92.6 14.5 2.2e-26 92.6 14.5 5.5 5 2 1 6 6 6 2 Domain of unknown function (DUF4200) PSRP-3_Ycf65 PF04839.13 EMC85113.1 - 0.056 13.7 0.0 0.14 12.4 0.0 1.8 1 0 0 1 1 1 0 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65) Amidohydro_3 PF07969.11 EMC85113.1 - 0.13 11.7 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Amidohydrolase family Mucin2_WxxW PF13330.6 EMC85113.1 - 9.5 7.1 8.3 2.3 9.1 0.3 3.4 3 0 0 3 3 3 0 Mucin-2 protein WxxW repeating region zf-C2H2 PF00096.26 EMC85114.1 - 4.1e-14 52.2 38.6 0.00061 20.1 0.4 6.5 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC85114.1 - 1.5e-11 44.1 38.1 0.01 16.6 0.6 6.4 6 0 0 6 6 6 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC85114.1 - 9.7e-07 29.0 32.0 0.011 16.1 0.1 5.8 5 1 1 6 6 6 3 Zinc-finger double domain zf-C2H2_aberr PF17017.5 EMC85114.1 - 4.8e-05 23.6 17.2 0.66 10.1 0.5 4.9 1 1 4 5 5 5 3 Aberrant zinc-finger zf-C2H2_8 PF15909.5 EMC85114.1 - 0.00019 21.7 15.5 0.024 14.9 1.8 4.0 1 1 3 4 4 4 3 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 EMC85114.1 - 0.19 11.8 22.5 2.1 8.5 1.9 5.3 5 0 0 5 5 5 0 C2H2-type zinc finger FOXP-CC PF16159.5 EMC85114.1 - 0.59 10.8 15.5 4.9 7.9 0.3 4.8 3 3 2 5 5 5 0 FOXP coiled-coil domain zf-met PF12874.7 EMC85114.1 - 5.6 7.5 21.8 2 8.9 1.1 5.5 5 0 0 5 5 5 0 Zinc-finger of C2H2 type Laminin_N PF00055.17 EMC85115.1 - 4.5e-62 209.7 0.0 4.5e-62 209.7 0.0 2.1 2 1 0 2 2 2 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.24 EMC85115.1 - 7.7e-26 90.0 69.1 9.8e-10 38.4 9.9 6.1 5 1 1 6 6 6 4 Laminin EGF domain NTR PF01759.21 EMC85115.1 - 5.8e-22 77.5 0.1 1.2e-21 76.5 0.1 1.6 1 0 0 1 1 1 1 UNC-6/NTR/C345C module F5_F8_type_C PF00754.25 EMC85115.1 - 0.06 13.5 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 F5/8 type C domain TMEM43 PF07787.12 EMC85116.1 - 8.1e-87 290.8 0.0 1.1e-86 290.3 0.0 1.2 1 0 0 1 1 1 1 Transmembrane protein 43 MerC PF03203.14 EMC85116.1 - 7.6 7.0 8.7 3.9 8.0 3.5 2.3 1 1 1 2 2 2 0 MerC mercury resistance protein BHD_3 PF10405.9 EMC85117.1 - 5.3e-26 90.8 0.0 1e-25 89.9 0.0 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 Rad4 PF03835.15 EMC85117.1 - 8.7e-21 74.1 5.6 8.7e-21 74.1 5.6 3.7 4 1 0 4 4 4 1 Rad4 transglutaminase-like domain BHD_1 PF10403.9 EMC85117.1 - 1.5e-16 60.0 0.0 3.3e-16 58.9 0.0 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 EMC85117.1 - 1.8e-14 54.4 0.5 1.8e-14 54.4 0.5 4.7 4 1 0 4 4 4 1 Rad4 beta-hairpin domain 2 LSM PF01423.22 EMC85118.1 - 2.4e-20 72.0 0.2 3.1e-20 71.6 0.2 1.2 1 0 0 1 1 1 1 LSM domain vATP-synt_E PF01991.18 EMC85118.1 - 0.045 13.1 0.1 0.063 12.7 0.1 1.4 1 1 1 2 2 2 0 ATP synthase (E/31 kDa) subunit DUF150_C PF17384.2 EMC85118.1 - 0.064 13.4 0.2 0.11 12.7 0.2 1.5 1 1 0 1 1 1 0 RimP C-terminal SH3 domain Glutaredoxin PF00462.24 EMC85118.1 - 0.17 12.2 0.0 0.29 11.4 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin SNF PF00209.18 EMC85120.1 - 8.3e-236 783.7 37.9 9.7e-236 783.5 37.9 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family PDZ PF00595.24 EMC85121.1 - 5.3e-93 305.5 2.1 4.4e-13 49.4 0.1 7.2 7 0 0 7 7 7 7 PDZ domain PDZ_6 PF17820.1 EMC85121.1 - 4.5e-70 231.4 9.2 2.1e-12 46.7 0.1 7.3 7 0 0 7 7 7 7 PDZ domain PDZ_2 PF13180.6 EMC85121.1 - 1.4e-37 127.9 0.8 1.9e-05 24.9 0.0 7.4 7 0 0 7 7 7 7 PDZ domain Tricorn_PDZ PF14685.6 EMC85121.1 - 1e-09 38.2 1.7 0.11 12.5 0.0 6.5 6 0 0 6 6 6 2 Tricorn protease PDZ domain GRASP55_65 PF04495.14 EMC85121.1 - 6.6e-05 23.3 0.0 5 7.5 0.0 4.8 4 2 1 6 6 6 2 GRASP55/65 PDZ-like domain PDZ_4 PF17816.1 EMC85121.1 - 0.014 15.8 0.7 12 6.3 0.0 4.6 6 0 0 6 6 6 0 PDZ domain EutA PF06277.11 EMC85121.1 - 0.07 12.0 0.2 0.39 9.5 0.1 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation protein EutA DUF4078 PF13300.6 EMC85122.1 - 1.5e-27 95.7 10.2 1.5e-27 95.7 10.2 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4078) WD-3 PF09765.9 EMC85124.1 - 0.043 13.2 0.4 0.068 12.5 0.4 1.3 1 0 0 1 1 1 0 WD-repeat region T2SSF PF00482.23 EMC85124.1 - 0.07 13.1 3.2 0.1 12.6 0.2 2.6 2 2 1 3 3 3 0 Type II secretion system (T2SS), protein F OEP PF02321.18 EMC85124.1 - 0.57 10.0 9.7 0.068 13.0 5.2 1.7 2 0 0 2 2 2 0 Outer membrane efflux protein CorA PF01544.18 EMC85124.1 - 1.1 8.5 4.7 1.2 8.4 0.5 2.4 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein CENP-H PF05837.12 EMC85124.1 - 3.2 8.2 15.0 0.36 11.3 1.5 3.1 3 0 0 3 3 3 0 Centromere protein H (CENP-H) Plexin_cytopl PF08337.12 EMC85125.1 - 7.2e-233 774.3 0.0 9.9e-233 773.8 0.0 1.2 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Sema PF01403.19 EMC85125.1 - 3e-58 197.7 0.0 4.3e-58 197.1 0.0 1.2 1 0 0 1 1 1 1 Sema domain TIG PF01833.24 EMC85125.1 - 1.6e-33 114.6 0.1 7.9e-11 41.9 1.0 6.2 6 1 0 6 6 6 4 IPT/TIG domain TIG_2 PF18020.1 EMC85125.1 - 2.4e-23 82.6 0.3 8.6e-22 77.6 0.2 3.1 3 0 0 3 3 3 1 TIG domain found in plexin TIG_plexin PF17960.1 EMC85125.1 - 2.5e-20 72.2 2.9 2e-19 69.4 0.0 3.5 4 0 0 4 4 4 1 TIG domain PSI PF01437.25 EMC85125.1 - 2e-16 60.3 48.2 2.3e-09 37.6 14.8 3.6 3 0 0 3 3 3 3 Plexin repeat Pkinase PF00069.25 EMC85126.1 - 5.9e-33 114.3 0.0 3e-32 112.0 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC85126.1 - 7e-14 51.7 0.0 3.6e-13 49.4 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC85126.1 - 0.00098 18.0 0.0 0.0015 17.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 EMC85126.1 - 0.13 11.3 0.1 0.2 10.6 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase SET PF00856.28 EMC85127.1 - 2.5e-07 31.2 0.1 2.5e-07 31.2 0.1 2.8 3 1 0 3 3 3 1 SET domain Copine PF07002.16 EMC85128.1 - 2.4e-86 288.7 0.0 3.2e-86 288.3 0.0 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 EMC85128.1 - 4.2e-24 84.8 0.0 4.1e-11 43.1 0.0 2.4 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 EMC85128.1 - 1.1e-06 28.9 0.0 2.7e-06 27.6 0.0 1.6 2 0 0 2 2 2 1 vWA found in TerF C terminus VCBS PF13517.6 EMC85128.1 - 0.0021 18.6 0.7 0.01 16.4 0.7 2.2 1 0 0 1 1 1 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Pkinase PF00069.25 EMC85129.1 - 1.7e-33 116.2 0.7 1.8e-33 116.0 0.7 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC85129.1 - 2.2e-19 69.8 0.3 2.4e-19 69.7 0.3 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EMC85129.1 - 0.058 13.0 0.1 0.064 12.8 0.1 1.1 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 EMC85129.1 - 0.09 12.1 0.1 0.096 12.0 0.1 1.4 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ada3 PF10198.9 EMC85131.1 - 2.3e-12 47.2 14.9 3.9e-09 36.7 2.8 3.5 2 1 1 3 3 3 2 Histone acetyltransferases subunit 3 NucS PF01939.16 EMC85131.1 - 0.052 12.9 0.9 0.085 12.2 0.9 1.3 1 0 0 1 1 1 0 Endonuclease NucS Occludin_ELL PF07303.13 EMC85131.1 - 0.64 10.8 5.3 19 6.1 4.3 2.5 2 0 0 2 2 2 0 Occludin homology domain YkyA PF10368.9 EMC85131.1 - 2.8 7.6 8.6 7.3 6.2 4.9 2.4 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein IL17_R_N PF15037.6 EMC85132.1 - 1.1e-64 218.8 11.5 4.8e-61 206.9 8.2 2.0 1 1 1 2 2 2 2 Interleukin-17 receptor extracellular region SEFIR PF08357.11 EMC85132.1 - 9.6e-10 38.9 0.0 1.5e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 SEFIR domain EGF_CA PF07645.15 EMC85133.1 - 1.6e-09 37.8 8.3 2.6e-09 37.1 8.3 1.3 1 0 0 1 1 1 1 Calcium-binding EGF domain Plasmod_Pvs28 PF06247.11 EMC85133.1 - 0.00095 19.4 3.2 0.0012 19.1 3.2 1.5 1 1 0 1 1 1 1 Pvs28 EGF domain TIL PF01826.17 EMC85133.1 - 0.011 15.9 7.8 0.016 15.4 7.8 1.2 1 0 0 1 1 1 0 Trypsin Inhibitor like cysteine rich domain hEGF PF12661.7 EMC85133.1 - 0.024 15.3 3.6 0.075 13.7 2.6 2.3 2 0 0 2 2 2 0 Human growth factor-like EGF EGF_3 PF12947.7 EMC85133.1 - 0.054 13.7 4.4 0.1 12.8 4.4 1.6 1 1 0 1 1 1 0 EGF domain EGF PF00008.27 EMC85133.1 - 0.41 11.0 4.1 0.32 11.4 2.5 1.7 1 1 0 1 1 1 0 EGF-like domain FXa_inhibition PF14670.6 EMC85133.1 - 0.52 10.6 6.6 0.94 9.8 6.6 1.5 1 0 0 1 1 1 0 Coagulation Factor Xa inhibitory site EB PF01683.18 EMC85133.1 - 0.9 9.9 8.1 1.4 9.3 8.1 1.3 1 0 0 1 1 1 0 EB module IHO1 PF15771.5 EMC85135.1 - 2.3e-78 264.4 13.3 2.8e-78 264.2 13.3 1.0 1 0 0 1 1 1 1 Interactor of HORMAD1 protein 1 Prominin PF05478.11 EMC85135.1 - 0.00051 18.1 6.1 0.00075 17.6 5.8 1.2 1 1 0 1 1 1 1 Prominin PKcGMP_CC PF16808.5 EMC85135.1 - 0.0036 17.1 2.4 0.0098 15.7 0.7 2.4 2 0 0 2 2 2 1 Coiled-coil N-terminus of cGMP-dependent protein kinase TolA_bind_tri PF16331.5 EMC85135.1 - 0.0065 16.5 4.9 0.015 15.3 4.9 1.6 1 1 0 1 1 1 1 TolA binding protein trimerisation PLC-beta_C PF08703.10 EMC85135.1 - 0.0081 16.2 0.9 0.0081 16.2 0.9 1.7 1 1 1 2 2 2 1 PLC-beta C terminal DUF2884 PF11101.8 EMC85135.1 - 0.01 15.3 1.1 0.017 14.6 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2884) Fib_alpha PF08702.10 EMC85135.1 - 0.016 15.4 3.1 0.029 14.6 3.1 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family zf-C4H2 PF10146.9 EMC85135.1 - 0.029 14.7 1.3 0.053 13.8 1.3 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein Tropomyosin_1 PF12718.7 EMC85135.1 - 0.033 14.3 3.5 0.033 14.3 3.5 2.2 1 1 1 2 2 2 0 Tropomyosin like DUF4570 PF15134.6 EMC85135.1 - 0.27 11.3 2.9 0.4 10.7 0.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4570) DUF16 PF01519.16 EMC85135.1 - 1.4 9.4 6.6 7.2 7.2 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 FAM76 PF16046.5 EMC85135.1 - 1.4 8.2 5.8 2.2 7.5 5.8 1.5 1 1 0 1 1 1 0 FAM76 protein CCDC71L PF15374.6 EMC85136.1 - 2.3e-165 550.7 18.4 2.6e-165 550.5 18.4 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 71L Zwilch PF09817.9 EMC85136.1 - 0.015 13.8 0.1 0.022 13.2 0.1 1.1 1 0 0 1 1 1 0 RZZ complex, subunit zwilch Laminin_EGF PF00053.24 EMC85137.1 - 6.7e-97 317.5 235.4 2e-11 43.9 6.8 12.1 10 2 2 12 12 12 11 Laminin EGF domain Laminin_II PF06009.12 EMC85137.1 - 0.0022 18.0 0.4 0.0022 18.0 0.4 3.4 3 0 0 3 3 3 1 Laminin Domain II PRKG1_interact PF15898.5 EMC85137.1 - 0.15 12.9 0.2 0.15 12.9 0.2 3.4 3 1 0 3 3 3 0 cGMP-dependent protein kinase interacting domain Alanine_zipper PF11839.8 EMC85137.1 - 1.5 9.2 51.4 0.36 11.2 7.7 4.4 4 1 0 4 4 4 0 Alanine-zipper, major outer membrane lipoprotein Tropomyosin_1 PF12718.7 EMC85137.1 - 6 7.0 19.1 1.9 8.7 1.2 3.4 3 1 0 3 3 3 0 Tropomyosin like UCH PF00443.29 EMC85138.1 - 4.3e-78 262.4 0.0 6.5e-78 261.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP19_linker PF16602.5 EMC85138.1 - 6.6e-55 184.8 8.2 6.6e-55 184.8 8.2 3.4 4 0 0 4 4 4 1 Linker region of USP19 deubiquitinase CS PF04969.16 EMC85138.1 - 1.5e-16 61.2 1.7 6.9e-11 43.0 0.2 2.7 2 0 0 2 2 2 2 CS domain UCH_1 PF13423.6 EMC85138.1 - 7.4e-14 52.1 0.0 7.1e-07 29.1 0.0 2.8 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase zf-MYND PF01753.18 EMC85138.1 - 4.1e-08 33.2 14.9 4.1e-08 33.2 14.9 3.1 4 0 0 4 4 4 1 MYND finger USP7_C2 PF14533.6 EMC85138.1 - 0.033 13.9 0.0 0.06 13.0 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-specific protease C-terminal Tudor_3 PF18115.1 EMC85138.1 - 0.16 11.9 0.1 4 7.4 0.0 2.4 2 0 0 2 2 2 0 DNA repair protein Crb2 Tudor domain zf-C6H2 PF15801.5 EMC85138.1 - 8.4 6.8 17.1 21 5.5 0.1 3.9 3 1 0 3 3 3 0 zf-MYND-like zinc finger, mRNA-binding SNF PF00209.18 EMC85139.1 - 1.8e-187 624.2 25.6 2.1e-187 624.0 25.6 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Crystall PF00030.19 EMC85140.1 - 9.6e-30 102.6 0.0 1.5e-17 63.5 0.0 2.0 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.13 EMC85140.1 - 0.002 18.0 0.0 0.97 9.4 0.0 2.3 2 0 0 2 2 2 2 Peptidase inhibitor family I36 IL4_i_Ig PF18258.1 EMC85140.1 - 0.12 12.7 0.3 84 3.5 0.0 3.4 3 1 1 4 4 4 0 Interleukin-4 inducing immunoglobulin-binding domain tRNA-synt_1c PF00749.21 EMC85141.1 - 9.8e-114 379.5 0.0 1.3e-113 379.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EMC85141.1 - 1.1e-48 165.5 0.0 2.1e-48 164.5 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.15 EMC85141.1 - 6.9e-30 103.8 1.9 1.2e-29 103.1 1.9 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 tRNA_synt_1c_R1 PF04558.15 EMC85141.1 - 9.5e-29 100.5 0.0 1.7e-28 99.7 0.0 1.5 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 DUF3504 PF12012.8 EMC85142.1 - 1.8e-62 210.0 1.5 1.8e-62 210.0 1.5 3.0 3 1 0 3 3 3 1 Domain of unknown function (DUF3504) CARD PF00619.21 EMC85142.1 - 0.0018 18.3 0.0 0.0052 16.8 0.0 1.8 1 0 0 1 1 1 1 Caspase recruitment domain PCNA_C PF02747.15 EMC85142.1 - 0.065 13.4 0.8 0.17 12.0 0.8 1.6 1 0 0 1 1 1 0 Proliferating cell nuclear antigen, C-terminal domain DUF498 PF04430.14 EMC85143.1 - 1.3e-23 83.1 0.0 1.3e-23 83.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) DALR_1 PF05746.15 EMC85144.1 - 5.8e-20 71.7 0.0 1.1e-19 70.8 0.0 1.5 1 0 0 1 1 1 1 DALR anticodon binding domain WD40 PF00400.32 EMC85145.1 - 1.8e-06 28.6 5.2 35 5.5 0.0 8.1 8 0 0 8 8 8 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC85145.1 - 0.0026 18.0 0.0 0.76 10.1 0.0 3.5 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain 2OG-FeII_Oxy_3 PF13640.6 EMC85146.1 - 1.3e-14 54.9 0.1 3.2e-14 53.6 0.1 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily EF-hand_7 PF13499.6 EMC85146.1 - 1.6e-08 34.9 0.0 5.4e-08 33.2 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EMC85146.1 - 1e-07 31.0 0.0 0.006 16.0 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EMC85146.1 - 5.4e-06 25.9 1.5 0.017 15.0 0.1 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 EMC85146.1 - 1.7e-05 24.1 0.1 0.13 11.8 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EMC85146.1 - 0.0003 20.6 0.0 0.18 11.7 0.0 2.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 EMC85146.1 - 0.049 14.0 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain TruB_C PF09142.11 EMC85146.1 - 0.19 11.5 0.0 0.38 10.6 0.0 1.4 1 0 0 1 1 1 0 tRNA Pseudouridine synthase II, C terminal Fz PF01392.22 EMC85147.1 - 1.4e-27 96.5 4.8 1.4e-27 96.5 4.8 1.7 2 0 0 2 2 2 1 Fz domain IBR PF01485.21 EMC85148.1 - 8.5e-21 74.0 45.5 4.1e-13 49.3 6.6 3.8 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EMC85148.1 - 0.0012 18.6 6.2 0.0012 18.6 6.2 4.1 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC85148.1 - 0.0018 18.1 9.8 0.0018 18.1 9.8 4.4 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC85148.1 - 0.011 16.1 47.0 0.037 14.4 9.9 4.1 2 1 1 3 3 3 0 Ring finger domain zf-RING_UBOX PF13445.6 EMC85148.1 - 0.022 14.8 3.2 0.022 14.8 3.2 3.6 3 0 0 3 3 3 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EMC85148.1 - 0.026 14.7 4.9 0.026 14.7 4.9 4.5 4 1 0 4 4 4 0 zinc finger of C3HC4-type, RING cNMP_binding PF00027.29 EMC85149.1 - 4.1e-42 142.2 0.0 5.4e-22 77.7 0.0 2.2 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain CRM1_repeat_2 PF18784.1 EMC85149.1 - 0.11 12.2 0.0 0.35 10.6 0.0 1.9 2 0 0 2 2 2 0 CRM1 / Exportin repeat 2 MaoC_dehydratas PF01575.19 EMC85150.1 - 1.1e-19 70.2 0.0 1.5e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EMC85150.1 - 1.1e-06 28.8 0.0 2.1e-06 27.9 0.0 1.5 1 1 0 1 1 1 1 N-terminal half of MaoC dehydratase 4HBT PF03061.22 EMC85150.1 - 0.00053 20.3 0.0 0.0021 18.4 0.0 2.0 1 1 2 3 3 3 1 Thioesterase superfamily Transket_pyr PF02779.24 EMC85151.1 - 2.5e-47 160.8 0.0 3.7e-47 160.3 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EMC85151.1 - 6.6e-38 129.4 0.1 2.1e-37 127.8 0.0 1.8 2 0 0 2 2 2 1 Transketolase, C-terminal domain BTB_2 PF02214.22 EMC85152.1 - 7.6e-22 77.5 0.1 2e-21 76.1 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain BTB_3 PF16017.5 EMC85152.1 - 0.0004 20.5 0.0 0.00067 19.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain ACOX PF01756.19 EMC85153.1 - 7.7e-66 221.1 2.5 1.1e-63 214.0 0.6 2.3 2 0 0 2 2 2 2 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 EMC85153.1 - 3.6e-29 101.9 0.1 8.4e-29 100.7 0.1 1.7 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 EMC85153.1 - 1.6e-06 28.4 0.0 3.9e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EMC85153.1 - 3.6e-06 27.1 0.0 7.4e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EMC85153.1 - 0.11 12.7 0.4 0.69 10.2 0.0 2.2 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain HTH_25 PF13413.6 EMC85153.1 - 0.15 12.0 0.0 0.57 10.1 0.0 2.0 1 0 0 1 1 1 0 Helix-turn-helix domain DUF1151 PF06625.11 EMC85154.1 - 2e-43 146.9 20.5 2.4e-43 146.7 20.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1151) TOPRIM_C PF16898.5 EMC85154.1 - 0.011 16.0 1.0 0.015 15.6 1.0 1.1 1 0 0 1 1 1 0 C-terminal associated domain of TOPRIM Synaptobrevin PF00957.21 EMC85154.1 - 0.47 10.3 2.0 0.67 9.8 2.0 1.4 1 0 0 1 1 1 0 Synaptobrevin ILEI PF15711.5 EMC85155.1 - 5.7e-25 87.6 0.1 9.6e-25 86.9 0.1 1.4 1 0 0 1 1 1 1 Interleukin-like EMT inducer DDE_Tnp_1 PF01609.21 EMC85155.1 - 0.1 12.3 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Transposase DDE domain Whirly PF08536.11 EMC85156.1 - 0.0012 18.7 0.1 0.0019 18.0 0.1 1.4 1 1 0 1 1 1 1 Whirly transcription factor GA-like PF17573.2 EMC85156.1 - 0.2 11.6 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 GA-like domain DUF667 PF05018.13 EMC85157.1 - 7.7e-37 126.8 0.0 1e-36 126.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF667) HIT PF01230.23 EMC85158.1 - 2.3e-10 41.1 0.0 2.6e-10 40.9 0.0 1.0 1 0 0 1 1 1 1 HIT domain SRP9-21 PF05486.12 EMC85159.1 - 1.2e-06 28.9 0.1 1.9e-06 28.2 0.1 1.5 1 1 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) EHN PF06441.12 EMC85160.1 - 2.3e-32 111.6 0.2 4.1e-32 110.8 0.2 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EMC85160.1 - 6.8e-19 68.5 0.0 1.2e-18 67.7 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMC85160.1 - 0.00036 21.2 0.3 0.17 12.5 0.2 2.3 2 0 0 2 2 2 2 Alpha/beta hydrolase family DUF1065 PF06358.11 EMC85160.1 - 0.16 11.9 0.0 0.47 10.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1065) RSN1_7TM PF02714.15 EMC85161.1 - 2.5e-58 197.5 26.8 2.5e-58 197.5 26.8 3.0 2 1 1 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EMC85161.1 - 2.6e-44 151.5 0.4 4.1e-44 150.9 0.4 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 EMC85161.1 - 4.6e-22 78.5 1.2 4.6e-22 78.5 1.2 4.6 6 0 0 6 6 6 1 Late exocytosis, associated with Golgi transport RRM_1 PF00076.22 EMC85161.1 - 0.017 14.9 0.1 0.57 10.0 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TGFb_propeptide PF00688.18 EMC85162.1 - 5.4e-18 65.6 0.8 2.6e-17 63.4 0.1 1.9 2 0 0 2 2 2 1 TGF-beta propeptide TGF_beta PF00019.20 EMC85162.1 - 2.9e-14 53.9 4.5 3.7e-13 50.3 4.5 2.3 1 1 0 1 1 1 1 Transforming growth factor beta like domain Sde2_N_Ubi PF13019.6 EMC85164.1 - 5.3e-24 84.9 1.5 6.4e-24 84.6 1.5 1.2 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain Exonuc_VII_L PF02601.15 EMC85164.1 - 0.098 12.2 1.4 0.12 11.9 1.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Histone PF00125.24 EMC85165.1 - 1.2e-43 148.6 0.4 1.3e-43 148.5 0.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EMC85165.1 - 4.4e-05 23.5 0.0 5.5e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EMC85165.1 - 0.00012 22.4 0.0 0.00015 22.0 0.0 1.1 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EMC85165.1 - 0.028 14.7 0.0 0.038 14.3 0.0 1.2 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EMC85165.1 - 0.12 12.4 0.0 0.16 12.1 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit GOLD_2 PF13897.6 EMC85166.1 - 8.8e-72 240.0 4.7 8.8e-72 240.0 4.7 3.2 2 1 0 2 2 2 1 Golgi-dynamics membrane-trafficking ACBP PF00887.19 EMC85166.1 - 9.1e-14 51.4 0.0 3.7e-13 49.5 0.0 2.1 1 0 0 1 1 1 1 Acyl CoA binding protein Merozoite_SPAM PF07133.11 EMC85166.1 - 1.1 9.3 31.3 0.36 10.8 18.3 2.3 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) DIRP PF06584.13 EMC85167.1 - 2.2e-47 159.6 0.3 6.2e-47 158.2 0.3 1.8 1 0 0 1 1 1 1 DIRP DUF2664 PF10867.8 EMC85167.1 - 0.012 16.0 0.2 0.042 14.3 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2664) FTA4 PF13093.6 EMC85167.1 - 0.092 12.6 6.2 0.036 13.9 3.4 2.0 2 1 0 2 2 2 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Med30 PF11315.8 EMC85167.1 - 0.44 10.7 4.9 0.22 11.7 1.8 2.1 2 1 0 2 2 2 0 Mediator complex subunit 30 PARP PF00644.20 EMC85168.1 - 1e-74 250.4 1.8 1.1e-74 250.3 0.0 2.0 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 EMC85168.1 - 8.1e-40 136.1 8.1 2.3e-39 134.6 1.7 3.3 2 2 0 2 2 2 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 EMC85168.1 - 1.4e-22 79.5 1.5 3.2e-22 78.4 0.2 2.3 2 0 0 2 2 2 1 WGR domain PADR1 PF08063.12 EMC85168.1 - 1.8e-21 75.7 0.5 3.2e-21 74.8 0.5 1.5 1 0 0 1 1 1 1 PADR1 (NUC008) domain BRCT PF00533.26 EMC85168.1 - 1.2e-10 41.6 0.1 4.9e-10 39.7 0.1 2.1 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain zf-PARP PF00645.18 EMC85168.1 - 0.00016 22.4 0.0 0.00016 22.4 0.0 3.5 3 0 0 3 3 3 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region BRCT_2 PF16589.5 EMC85168.1 - 0.0028 18.0 0.1 0.01 16.2 0.1 1.9 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Spec3 PF15795.5 EMC85169.1 - 2.5e-27 95.2 10.3 3.1e-27 94.9 10.3 1.1 1 0 0 1 1 1 1 Ectodermal ciliogenesis protein NDUF_B12 PF08122.12 EMC85169.1 - 0.15 12.2 1.2 0.21 11.6 0.4 1.7 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase B12 subunit family IPK PF03770.16 EMC85170.1 - 8.1e-45 153.1 0.0 1.7e-44 152.1 0.0 1.5 1 1 0 1 1 1 1 Inositol polyphosphate kinase Retrotrans_gag PF03732.17 EMC85170.1 - 0.011 16.0 0.8 0.45 10.8 0.0 2.7 2 0 0 2 2 2 0 Retrotransposon gag protein Presenilin PF01080.17 EMC85171.1 - 9.1e-161 535.1 15.1 8.8e-113 377.1 12.0 2.3 2 1 1 3 3 3 2 Presenilin DUF4643 PF15485.6 EMC85171.1 - 0.038 13.8 0.7 0.038 13.8 0.7 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4643) ABC1 PF03109.16 EMC85172.1 - 4.4e-34 117.2 0.0 9.8e-34 116.1 0.0 1.6 1 0 0 1 1 1 1 ABC1 family CNH PF00780.22 EMC85173.1 - 1.6e-77 260.9 0.1 2.9e-77 260.0 0.1 1.5 1 0 0 1 1 1 1 CNH domain KELK PF15796.5 EMC85173.1 - 1.1e-32 112.3 20.6 1.1e-32 112.3 20.6 7.5 5 3 2 7 7 7 2 KELK-motif containing domain of MRCK Ser/Thr protein kinase Pkinase PF00069.25 EMC85173.1 - 2.8e-29 102.3 0.6 8.1e-29 100.8 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain DMPK_coil PF08826.10 EMC85173.1 - 1.1e-25 89.5 11.6 1.1e-25 89.5 11.6 9.3 7 4 3 11 11 11 2 DMPK coiled coil domain like Pkinase_Tyr PF07714.17 EMC85173.1 - 5.7e-13 48.7 0.0 2e-12 47.0 0.0 1.9 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 EMC85173.1 - 1.9e-11 43.6 8.1 1.9e-11 43.6 8.1 2.0 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 EMC85173.1 - 5.3e-05 23.8 3.1 8.2e-05 23.2 1.6 2.2 2 0 0 2 2 2 1 Protein kinase C terminal domain PBD PF00786.28 EMC85173.1 - 0.0084 16.4 0.1 0.066 13.6 0.0 2.6 2 0 0 2 2 2 1 P21-Rho-binding domain Calici_MSP PF05752.11 EMC85173.1 - 0.79 9.5 5.1 2.9 7.7 4.6 2.3 1 1 1 2 2 2 0 Calicivirus minor structural protein OCC1 PF15506.6 EMC85174.1 - 3.3e-21 75.2 0.1 5.2e-21 74.5 0.1 1.3 1 0 0 1 1 1 1 OCC1 family BAR_3 PF16746.5 EMC85175.1 - 2.3e-60 204.3 10.9 4.3e-60 203.4 10.9 1.4 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 EMC85175.1 - 2.6e-08 34.3 0.0 1.5e-07 31.9 0.0 2.3 2 0 0 2 2 2 1 PH domain PID PF00640.23 EMC85175.1 - 8.6e-08 32.3 0.2 2.4e-07 30.9 0.2 1.8 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 EMC85175.1 - 2.3e-05 24.5 0.1 5.5e-05 23.3 0.1 1.6 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PH_2 PF08458.10 EMC85175.1 - 0.0042 17.4 0.0 0.017 15.5 0.0 2.1 2 0 0 2 2 2 1 Plant pleckstrin homology-like region PH_9 PF15410.6 EMC85175.1 - 0.0069 16.7 0.0 0.027 14.8 0.0 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain DUF3263 PF11662.8 EMC85175.1 - 0.028 14.3 0.2 0.092 12.6 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3263) PH_17 PF18012.1 EMC85175.1 - 0.085 12.6 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 PH domain BAR PF03114.18 EMC85175.1 - 0.31 10.6 6.4 0.53 9.9 5.6 1.8 1 1 0 1 1 1 0 BAR domain Aldedh PF00171.22 EMC85176.1 - 3.9e-161 536.7 0.0 5.2e-161 536.2 0.0 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Formyl_trans_N PF00551.19 EMC85176.1 - 3.4e-45 154.0 0.0 6.9e-45 153.0 0.0 1.5 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 EMC85176.1 - 6.2e-15 55.3 0.0 1.6e-14 54.0 0.0 1.6 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain PP-binding PF00550.25 EMC85176.1 - 4.3e-05 23.8 0.0 0.0001 22.6 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site DUF1487 PF07368.11 EMC85176.1 - 0.0062 16.0 0.0 0.019 14.4 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1487) DUF4598 PF15370.6 EMC85177.1 - 3.7e-15 56.4 1.6 4.8e-15 56.0 1.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4598) Sigma70_r1_1 PF03979.14 EMC85177.1 - 0.023 14.8 6.7 0.044 13.9 6.6 1.6 1 1 0 1 1 1 0 Sigma-70 factor, region 1.1 MgtE PF01769.16 EMC85178.1 - 1.8e-51 173.7 12.6 4.3e-30 104.6 0.8 3.0 4 0 0 4 4 4 2 Divalent cation transporter Sulfotransfer_2 PF03567.14 EMC85179.1 - 3.3e-69 233.6 7.1 3.9e-69 233.4 7.1 1.1 1 0 0 1 1 1 1 Sulfotransferase family TGFb_propeptide PF00688.18 EMC85181.1 - 1.6e-36 126.3 0.5 2.6e-36 125.6 0.5 1.3 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 EMC85181.1 - 9.7e-35 119.7 0.6 1.9e-34 118.7 0.6 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain Cpn60_TCP1 PF00118.24 EMC85182.1 - 1.6e-153 511.9 15.3 1.8e-153 511.8 15.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Phage_tail_X PF05489.12 EMC85182.1 - 0.056 13.1 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Phage Tail Protein X UPF0564 PF10595.9 EMC85183.1 - 1.5e-56 192.1 50.6 4.5e-56 190.5 50.6 1.8 1 1 0 1 1 1 1 Uncharacterised protein family UPF0564 DHC PF09626.10 EMC85183.1 - 0.053 14.4 0.9 0.053 14.4 0.9 2.3 2 1 0 2 2 2 0 Dihaem cytochrome c P4Ha_N PF08336.11 EMC85183.1 - 4.8 7.2 9.3 1.5 8.9 0.6 3.4 3 1 0 3 3 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Cadherin PF00028.17 EMC85184.1 - 1.2e-08 35.2 0.1 2.8e-08 34.1 0.1 1.7 1 0 0 1 1 1 1 Cadherin domain DUF5335 PF17269.2 EMC85184.1 - 0.046 13.6 0.2 0.15 11.9 0.2 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5335) DUF3377 PF11857.8 EMC85184.1 - 0.2 11.6 1.7 0.27 11.2 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) Cadherin PF00028.17 EMC85186.1 - 6.1e-27 93.9 0.4 3.1e-18 66.0 0.0 2.6 2 1 0 2 2 2 2 Cadherin domain RET_CLD1 PF17756.1 EMC85186.1 - 0.12 12.6 0.0 11 6.3 0.0 2.2 2 0 0 2 2 2 0 RET Cadherin like domain 1 Cadherin PF00028.17 EMC85187.1 - 1.6e-121 397.0 14.6 4.6e-20 71.9 0.0 7.1 7 0 0 7 7 7 7 Cadherin domain Cadherin_3 PF16184.5 EMC85187.1 - 5.4e-13 48.9 14.5 0.04 13.9 0.2 7.1 7 2 0 7 7 7 6 Cadherin-like Cadherin_2 PF08266.12 EMC85187.1 - 9.7e-07 28.5 1.5 0.62 9.9 0.0 5.0 7 0 0 7 7 7 2 Cadherin-like SusE PF14292.6 EMC85187.1 - 1.1e-05 25.6 17.2 0.38 11.0 0.1 6.9 4 3 2 6 6 6 2 SusE outer membrane protein DUF3342 PF11822.8 EMC85188.1 - 5.5e-37 125.9 1.5 1.1e-36 124.9 1.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) HNH_5 PF14279.6 EMC85188.1 - 0.087 12.7 3.2 1.6 8.6 0.1 3.0 2 0 0 2 2 2 0 HNH endonuclease CHORD PF04968.12 EMC85188.1 - 0.24 12.1 6.9 0.12 13.1 2.8 2.7 2 1 0 2 2 2 0 CHORD TPD PF14811.6 EMC85189.1 - 0.061 13.2 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function TPD sequence-motif TFIID_20kDa PF03847.13 EMC85189.1 - 0.29 11.7 2.9 62 4.2 0.0 3.8 4 0 0 4 4 4 0 Transcription initiation factor TFIID subunit A RHD_DNA_bind PF00554.22 EMC85190.1 - 3.1e-76 255.0 0.0 4.7e-76 254.4 0.0 1.3 1 0 0 1 1 1 1 Rel homology DNA-binding domain RHD_dimer PF16179.5 EMC85190.1 - 3e-37 126.8 0.0 4.8e-37 126.1 0.0 1.3 1 0 0 1 1 1 1 Rel homology dimerisation domain zf-C2H2 PF00096.26 EMC85191.1 - 3.9e-27 93.2 55.3 4.7e-06 26.8 2.8 7.5 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC85191.1 - 6e-16 57.8 51.9 0.0015 19.2 1.3 7.6 7 0 0 7 7 7 6 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC85191.1 - 7.6e-16 57.7 55.0 2.6e-07 30.8 1.3 8.9 9 0 0 9 9 8 4 Zinc-finger double domain zf-H2C2_5 PF13909.6 EMC85191.1 - 3.2e-05 23.6 35.9 8.2e-05 22.3 3.9 4.9 5 0 0 5 5 5 2 C2H2-type zinc-finger domain DUF3268 PF11672.8 EMC85191.1 - 0.00035 20.9 15.6 0.0082 16.5 1.4 2.7 2 1 0 2 2 2 2 zinc-finger-containing domain BSP_II PF05432.11 EMC85191.1 - 0.011 15.5 12.1 0.018 14.8 12.1 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) RNA_pol_3_Rpc31 PF11705.8 EMC85191.1 - 0.038 14.3 7.8 0.076 13.3 7.8 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 GAGA PF09237.11 EMC85191.1 - 0.064 13.1 7.0 2.3 8.1 0.3 2.9 2 1 0 2 2 2 0 GAGA factor Astro_capsid_p PF12226.8 EMC85191.1 - 0.22 10.6 5.9 0.35 10.0 5.9 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Ribosomal_60s PF00428.19 EMC85191.1 - 0.61 10.7 11.7 1.3 9.7 11.7 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein DNA_pol_phi PF04931.13 EMC85191.1 - 1 7.4 14.5 1.4 7.0 14.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 EMC85191.1 - 1.1 8.5 21.1 0.01 15.2 8.7 2.2 2 0 0 2 2 2 0 NOA36 protein Nop14 PF04147.12 EMC85191.1 - 2.1 6.5 10.3 2.9 6.0 10.3 1.1 1 0 0 1 1 1 0 Nop14-like family CENP-B_dimeris PF09026.10 EMC85191.1 - 2.7 8.4 14.4 6 7.3 14.4 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Actin_micro PF17003.5 EMC85191.1 - 3.2 6.8 12.5 4.5 6.3 0.2 3.8 3 1 0 3 3 3 0 Putative actin-like family DUF2256 PF10013.9 EMC85191.1 - 3.6 7.8 14.3 12 6.1 0.4 4.8 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) FAM176 PF14851.6 EMC85191.1 - 3.6 7.2 7.4 8.6 6.0 7.4 1.6 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 EMC85191.1 - 4.6 5.4 6.5 6.4 4.9 6.5 1.1 1 0 0 1 1 1 0 CDC45-like protein PPP4R2 PF09184.11 EMC85191.1 - 5 6.6 16.3 0.54 9.8 10.0 2.1 2 0 0 2 2 2 0 PPP4R2 WD-3 PF09765.9 EMC85193.1 - 2e-105 352.2 0.4 2.3e-105 352.0 0.4 1.0 1 0 0 1 1 1 1 WD-repeat region FANCL_C PF11793.8 EMC85193.1 - 5.1e-30 103.5 3.0 9.5e-30 102.6 3.0 1.5 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_2 PF13639.6 EMC85193.1 - 1.3e-05 25.4 3.1 3.3e-05 24.1 3.1 1.7 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EMC85193.1 - 0.17 12.2 4.0 0.57 10.5 4.0 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EMC85193.1 - 0.23 11.5 2.1 0.78 9.8 2.1 2.1 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Pkinase PF00069.25 EMC85195.1 - 6.4e-16 58.5 0.0 1.3e-15 57.5 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC85195.1 - 2.2e-10 40.3 0.0 3.7e-10 39.5 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMC85195.1 - 0.0053 16.1 0.0 0.0074 15.7 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMC85195.1 - 0.018 13.8 0.0 0.021 13.6 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Pentapeptide_2 PF01469.18 EMC85197.1 - 0.00013 21.8 23.6 1.3 8.9 0.7 5.4 1 1 7 8 8 8 8 Pentapeptide repeats (8 copies) PMG PF05287.12 EMC85197.1 - 0.035 14.2 0.0 11 6.0 0.0 2.6 1 1 2 3 3 3 0 PMG protein Pentapeptide_2 PF01469.18 EMC85198.1 - 0.00013 21.8 23.6 1.3 8.9 0.7 5.4 1 1 7 8 8 8 8 Pentapeptide repeats (8 copies) PMG PF05287.12 EMC85198.1 - 0.035 14.2 0.0 11 6.0 0.0 2.6 1 1 2 3 3 3 0 PMG protein TF_AP-2 PF03299.14 EMC85199.1 - 1.9e-87 292.3 0.0 2.6e-87 291.9 0.0 1.2 1 0 0 1 1 1 1 Transcription factor AP-2 TF_AP-2 PF03299.14 EMC85200.1 - 4.3e-85 284.7 0.0 7.5e-85 283.9 0.0 1.4 1 0 0 1 1 1 1 Transcription factor AP-2 CAP PF00188.26 EMC85201.1 - 6.9e-26 91.5 2.2 9.2e-26 91.1 2.2 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Crisp PF08562.10 EMC85201.1 - 2.7e-20 72.7 13.1 6.9e-20 71.4 13.1 1.7 1 0 0 1 1 1 1 Crisp p450 PF00067.22 EMC85202.1 - 3.8e-142 474.3 0.0 4.5e-142 474.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EMC85203.1 - 1.1e-134 449.7 0.1 1.3e-134 449.5 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 CENP-Q PF13094.6 EMC85204.1 - 5.9e-15 55.9 15.8 8.4e-15 55.4 15.8 1.2 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit DUF812 PF05667.11 EMC85204.1 - 0.00073 18.6 9.0 0.00073 18.6 9.0 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF812) THOC7 PF05615.13 EMC85204.1 - 0.0034 17.7 9.9 0.0034 17.7 9.9 1.8 2 0 0 2 2 2 1 Tho complex subunit 7 Interfer-bind PF09294.10 EMC85204.1 - 0.072 13.4 2.5 0.18 12.1 0.9 2.1 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III DUF489 PF04356.12 EMC85204.1 - 0.096 12.7 8.6 0.043 13.8 5.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF489) SUB1_ProdP9 PF18213.1 EMC85204.1 - 0.12 12.2 2.1 0.87 9.5 0.2 2.7 2 1 0 2 2 2 0 SUB1 protease Prodomain ProdP9 GAS PF13851.6 EMC85204.1 - 0.15 11.4 21.8 0.042 13.2 15.7 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Exonuc_VII_L PF02601.15 EMC85204.1 - 0.3 10.6 9.2 0.38 10.3 9.2 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4449 PF14613.6 EMC85204.1 - 0.45 10.6 7.6 0.7 10.0 7.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4449) Prominin PF05478.11 EMC85204.1 - 0.5 8.3 10.8 0.79 7.6 10.8 1.2 1 0 0 1 1 1 0 Prominin DUF4011 PF13195.6 EMC85204.1 - 0.63 10.0 8.7 0.053 13.5 3.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4011) Plasmid_RAQPRD PF09686.10 EMC85204.1 - 2.9 8.2 7.0 1.7 8.9 4.7 1.9 2 0 0 2 2 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) DivIC PF04977.15 EMC85204.1 - 3.1 7.6 14.1 0.43 10.4 8.9 2.2 2 0 0 2 2 2 0 Septum formation initiator DUF724 PF05266.14 EMC85204.1 - 3.9 7.3 14.4 0.45 10.3 8.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Nsp1_C PF05064.13 EMC85204.1 - 4.1 7.2 15.3 1.7 8.5 7.9 2.5 2 0 0 2 2 2 0 Nsp1-like C-terminal region DUF1664 PF07889.12 EMC85204.1 - 4.7 7.3 14.4 0.45 10.6 7.6 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) MM_CoA_mutase PF01642.22 EMC85205.1 - 1.3e-237 789.4 0.0 1.6e-237 789.2 0.0 1.1 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase B12-binding PF02310.19 EMC85205.1 - 2.1e-14 53.6 0.3 5.9e-14 52.1 0.3 1.8 1 0 0 1 1 1 1 B12 binding domain 7tm_1 PF00001.21 EMC85206.1 - 2e-31 109.3 13.7 2.4e-31 109.0 13.7 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 EMC85206.1 - 3.4e-06 26.6 11.1 5.4e-06 26.0 11.1 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv FSAP_sig_propep PF03032.15 EMC85207.1 - 0.064 13.3 0.4 0.064 13.3 0.4 2.0 2 0 0 2 2 2 0 Frog skin active peptide family signal and propeptide Filament PF00038.21 EMC85208.1 - 1.7e-103 346.5 39.9 1.9e-103 346.3 39.9 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.5 EMC85208.1 - 1e-25 90.8 81.2 1e-25 90.8 81.2 2.1 1 1 1 2 2 2 1 Keratin type II head ATG16 PF08614.11 EMC85208.1 - 7.5e-06 26.3 30.8 0.0015 18.8 4.7 2.5 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 EMC85208.1 - 2.3e-05 24.4 40.5 0.0024 17.9 1.4 3.5 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 EMC85208.1 - 0.00025 20.1 37.9 0.0012 17.9 10.6 3.0 1 1 2 3 3 3 2 Spc7 kinetochore protein AAA_13 PF13166.6 EMC85208.1 - 0.0012 17.6 19.0 0.0012 17.6 19.0 2.1 1 1 1 2 2 2 1 AAA domain Baculo_PEP_C PF04513.12 EMC85208.1 - 0.0051 16.8 13.3 1.2 9.2 1.0 4.0 1 1 3 4 4 4 2 Baculovirus polyhedron envelope protein, PEP, C terminus JIP_LZII PF16471.5 EMC85208.1 - 0.017 15.3 25.4 0.15 12.2 0.9 5.2 5 1 0 5 5 5 0 JNK-interacting protein leucine zipper II DUF1664 PF07889.12 EMC85208.1 - 0.034 14.2 22.8 0.051 13.6 3.5 4.3 3 1 0 4 4 4 0 Protein of unknown function (DUF1664) LPP PF04728.13 EMC85208.1 - 0.034 14.5 7.9 0.043 14.2 1.0 4.1 4 0 0 4 4 4 0 Lipoprotein leucine-zipper DASH_Dam1 PF08653.10 EMC85208.1 - 0.034 13.9 2.3 58 3.6 0.0 4.1 4 0 0 4 4 4 0 DASH complex subunit Dam1 Taxilin PF09728.9 EMC85208.1 - 0.056 12.6 29.5 0.53 9.4 21.6 2.6 1 1 2 3 3 3 0 Myosin-like coiled-coil protein ADIP PF11559.8 EMC85208.1 - 0.12 12.4 34.9 0.089 12.9 13.2 3.6 2 2 1 3 3 3 0 Afadin- and alpha -actinin-Binding DUF883 PF05957.13 EMC85208.1 - 0.21 12.2 19.8 1.1 9.9 7.2 3.9 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF883) Fib_alpha PF08702.10 EMC85208.1 - 0.26 11.5 26.5 0.046 13.9 1.5 3.7 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family CENP-F_leu_zip PF10473.9 EMC85208.1 - 0.31 11.1 37.9 0.93 9.5 16.4 3.9 1 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CHDCT2 PF08074.11 EMC85208.1 - 0.33 11.1 17.6 0.79 9.9 3.0 2.7 1 1 1 2 2 2 0 CHDCT2 (NUC038) domain HemY_N PF07219.13 EMC85208.1 - 0.4 10.9 3.1 0.79 9.9 3.1 1.4 1 0 0 1 1 1 0 HemY protein N-terminus Alanine_zipper PF11839.8 EMC85208.1 - 0.47 10.8 7.0 1.5 9.2 7.0 1.8 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein FapA PF03961.13 EMC85208.1 - 1.8 7.1 31.1 0.65 8.5 5.6 2.9 1 1 2 3 3 3 0 Flagellar Assembly Protein A Asp2 PF16929.5 EMC85208.1 - 1.8 7.5 12.9 0.2 10.6 7.2 2.1 1 1 1 2 2 2 0 Accessory Sec system GspB-transporter YabA PF06156.13 EMC85208.1 - 2.1 9.0 38.2 6.7 7.4 2.2 5.0 2 2 3 5 5 5 0 Initiation control protein YabA FUSC PF04632.12 EMC85208.1 - 2.8 6.4 9.9 1.6 7.2 5.9 2.0 2 0 0 2 2 2 0 Fusaric acid resistance protein family CALCOCO1 PF07888.11 EMC85208.1 - 3.3 6.5 36.2 10 4.9 11.5 2.2 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like BicD PF09730.9 EMC85208.1 - 3.5 6.0 30.5 0.38 9.1 15.2 2.3 1 1 0 2 2 2 0 Microtubule-associated protein Bicaudal-D UPF0242 PF06785.11 EMC85208.1 - 3.7 7.6 38.9 3.3 7.8 5.3 3.4 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus ApoO PF09769.9 EMC85208.1 - 4.2 7.3 10.3 5.9 6.9 0.1 3.9 3 1 0 3 3 3 0 Apolipoprotein O DUF4763 PF15960.5 EMC85208.1 - 4.5 6.5 26.4 0.036 13.4 8.2 3.3 2 2 1 3 3 3 0 Domain of unknown function (DUF4763) Tropomyosin_1 PF12718.7 EMC85208.1 - 5 7.3 39.1 0.95 9.6 16.3 3.3 1 1 1 3 3 3 0 Tropomyosin like Topoisom_I_N PF02919.15 EMC85208.1 - 5.6 6.4 7.2 2 7.9 2.9 2.2 2 0 0 2 2 2 0 Eukaryotic DNA topoisomerase I, DNA binding fragment DUF4407 PF14362.6 EMC85208.1 - 6.6 6.0 27.0 1.8e+04 -6.7 27.0 2.4 1 1 0 1 1 0 0 Domain of unknown function (DUF4407) bZIP_1 PF00170.21 EMC85208.1 - 7.1 6.8 29.7 0.78 9.9 1.8 5.4 4 2 1 5 5 5 0 bZIP transcription factor Golgin_A5 PF09787.9 EMC85208.1 - 8.7 5.7 41.0 0.18 11.2 11.5 3.6 1 1 1 3 3 3 0 Golgin subfamily A member 5 TolA_bind_tri PF16331.5 EMC85208.1 - 9.1 6.4 31.7 8.2 6.6 8.3 5.6 5 1 1 6 6 6 0 TolA binding protein trimerisation Collagen PF01391.18 EMC85209.1 - 1.1 9.1 23.4 0.85 9.4 6.5 2.4 2 1 0 2 2 2 0 Collagen triple helix repeat (20 copies) zinc_ribbon_15 PF17032.5 EMC85210.1 - 0.013 16.2 5.6 42 5.0 0.6 4.4 1 1 2 3 3 3 0 zinc-ribbon family Zn_ribbon_SprT PF17283.2 EMC85210.1 - 0.33 10.9 17.1 2.1e+02 1.9 0.0 7.2 8 0 0 8 8 8 0 SprT-like zinc ribbon domain Collagen PF01391.18 EMC85211.1 - 6.7e-21 73.8 47.6 1.8e+04 -4.6 47.6 5.9 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) Cornifin PF02389.15 EMC85212.1 - 1.3e-05 25.4 41.2 0.021 15.0 13.7 2.4 1 1 1 2 2 2 2 Cornifin (SPRR) family PHTB1_C PF14728.6 EMC85213.1 - 9.5e-142 472.5 0.8 1.3e-141 472.0 0.8 1.2 1 0 0 1 1 1 1 PTHB1 C-terminus PHTB1_N PF14727.6 EMC85213.1 - 1.8e-99 334.0 0.1 2.3e-99 333.6 0.1 1.1 1 0 0 1 1 1 1 PTHB1 N-terminus ANTH PF07651.16 EMC85213.1 - 1.7 7.6 4.7 0.9 8.5 1.2 2.0 2 0 0 2 2 2 0 ANTH domain 7tm_1 PF00001.21 EMC85214.1 - 2.1e-41 142.0 13.2 2.7e-41 141.6 13.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC85214.1 - 0.00066 19.5 2.4 0.00066 19.5 2.4 2.0 1 1 0 2 2 2 1 Olfactory receptor MRAP PF15183.6 EMC85214.1 - 1.5 8.9 5.2 0.78 9.7 0.3 2.6 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family Dpy19 PF10034.9 EMC85215.1 - 2.8e-239 795.7 23.7 3.4e-239 795.4 23.7 1.1 1 0 0 1 1 1 1 Q-cell neuroblast polarisation T-box PF00907.22 EMC85216.1 - 6.1e-70 235.2 0.0 8.2e-70 234.8 0.0 1.2 1 0 0 1 1 1 1 T-box ubiquitin PF00240.23 EMC85217.1 - 1.3e-07 31.3 0.1 1.9e-07 30.7 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 EMC85217.1 - 0.00071 20.1 0.0 0.0015 19.1 0.0 1.5 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain SOBP PF15279.6 EMC85217.1 - 0.25 11.9 9.2 0.34 11.5 9.2 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Septin PF00735.18 EMC85218.1 - 3e-124 413.9 0.1 3e-124 413.9 0.1 1.9 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EMC85218.1 - 3.5e-07 30.3 1.2 8.1e-07 29.1 0.0 2.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC85218.1 - 2e-05 24.6 12.9 0.00025 21.0 0.4 3.4 3 1 0 3 3 3 2 RsgA GTPase AIG1 PF04548.16 EMC85218.1 - 0.001 18.4 0.0 0.001 18.4 0.0 2.6 3 0 0 3 3 3 1 AIG1 family GTP_EFTU PF00009.27 EMC85218.1 - 0.0074 15.8 9.8 0.65 9.5 0.1 3.9 3 1 0 3 3 3 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EMC85218.1 - 0.0075 16.7 0.4 0.028 14.8 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain FeoB_N PF02421.18 EMC85218.1 - 0.019 14.5 0.0 0.055 13.0 0.0 1.8 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_22 PF13401.6 EMC85218.1 - 0.019 15.2 1.6 0.036 14.3 0.0 2.2 2 1 0 2 2 2 0 AAA domain Ras PF00071.22 EMC85218.1 - 0.02 14.5 1.9 0.039 13.5 0.0 2.3 2 0 0 2 2 2 0 Ras family ABC_tran PF00005.27 EMC85218.1 - 0.026 15.1 0.0 0.026 15.1 0.0 2.7 3 1 0 3 3 2 0 ABC transporter AAA_29 PF13555.6 EMC85218.1 - 0.043 13.6 0.0 0.089 12.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 EMC85218.1 - 0.054 13.7 0.0 0.23 11.7 0.0 2.1 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EMC85218.1 - 0.073 12.4 0.0 0.073 12.4 0.0 2.9 3 0 0 3 3 3 0 Gtr1/RagA G protein conserved region Fez1 PF06818.15 EMC85218.1 - 0.19 12.1 26.2 0.053 14.0 22.5 1.8 2 0 0 2 2 2 0 Fez1 Exonuc_VII_L PF02601.15 EMC85218.1 - 2.4 7.7 19.0 3.5 7.1 19.0 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit Snf7 PF03357.21 EMC85219.1 - 1.3e-36 125.8 29.6 1.5e-36 125.6 29.6 1.0 1 0 0 1 1 1 1 Snf7 VirE_N PF08800.10 EMC85219.1 - 0.048 13.8 0.6 0.063 13.4 0.6 1.3 1 0 0 1 1 1 0 VirE N-terminal domain YlqD PF11068.8 EMC85219.1 - 1.7 9.0 17.6 0.75 10.2 5.8 2.1 1 1 1 2 2 2 0 YlqD protein PEP-utilisers_N PF05524.13 EMC85219.1 - 5 7.3 12.2 4.7 7.4 1.6 2.2 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal DUF2570 PF10828.8 EMC85219.1 - 6.9 6.5 17.8 1.7 8.5 5.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) DUF908 PF06012.12 EMC85220.1 - 2.7 7.3 8.5 5.5 6.3 8.6 1.6 1 1 0 1 1 1 0 Domain of Unknown Function (DUF908) Fibrinogen_C PF00147.18 EMC85221.1 - 1.4e-69 234.2 5.9 2.1e-69 233.7 5.9 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Furin-like_2 PF15913.5 EMC85222.1 - 9.9e-34 115.7 26.5 2e-33 114.7 20.7 3.0 2 1 0 2 2 2 1 Furin-like repeat, cysteine-rich Toprim PF01751.22 EMC85222.1 - 0.17 12.1 0.0 0.25 11.6 0.0 1.2 1 0 0 1 1 1 0 Toprim domain ITI_HC_C PF06668.12 EMC85223.1 - 4.1e-71 238.5 0.1 7e-71 237.8 0.1 1.4 1 0 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus VIT PF08487.10 EMC85223.1 - 3.9e-33 114.0 4.0 8e-33 113.0 4.0 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.28 EMC85223.1 - 6.8e-21 75.3 0.0 1.4e-20 74.3 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EMC85223.1 - 2e-13 50.6 0.0 3.2e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EMC85223.1 - 3.3e-11 43.8 0.1 9.4e-11 42.3 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 EMC85223.1 - 0.00077 19.6 0.0 0.0014 18.8 0.0 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA_CoxE PF05762.14 EMC85223.1 - 0.0032 16.9 0.0 0.0057 16.1 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein Lip_prot_lig_C PF10437.9 EMC85223.1 - 0.14 12.2 0.6 0.5 10.4 0.2 2.2 2 0 0 2 2 2 0 Bacterial lipoate protein ligase C-terminus VIT PF08487.10 EMC85224.1 - 2.9e-32 111.2 0.6 2.9e-32 111.2 0.6 1.9 2 0 0 2 2 2 1 Vault protein inter-alpha-trypsin domain VWA PF00092.28 EMC85224.1 - 1.6e-24 87.1 0.1 3e-24 86.2 0.1 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EMC85224.1 - 3e-17 63.0 0.0 4.8e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EMC85224.1 - 1.7e-14 54.3 0.6 5e-14 52.8 0.1 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 EMC85224.1 - 4.1e-07 29.6 0.0 7.3e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein vWA-TerF-like PF10138.9 EMC85224.1 - 0.00039 20.6 0.0 0.00069 19.8 0.0 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus DUF2201 PF09967.9 EMC85224.1 - 0.0042 17.2 0.1 0.01 16.0 0.1 1.7 1 0 0 1 1 1 1 VWA-like domain (DUF2201) Spectrin PF00435.21 EMC85224.1 - 0.069 13.6 2.8 0.25 11.8 0.5 2.4 2 0 0 2 2 2 0 Spectrin repeat Ribosomal_TL5_C PF14693.6 EMC85224.1 - 0.074 13.4 0.1 16 6.0 0.1 2.7 2 0 0 2 2 2 0 Ribosomal protein TL5, C-terminal domain DUF1694 PF07997.11 EMC85224.1 - 0.11 12.6 1.1 1.1 9.4 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1694) CobT_C PF11775.8 EMC85224.1 - 0.13 11.9 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT VWA domain Mustang PF15682.5 EMC85225.1 - 2.3e-41 139.7 2.9 2.5e-41 139.6 2.9 1.0 1 0 0 1 1 1 1 Musculoskeletal, temporally activated-embryonic nuclear protein 1 STIMATE PF12400.8 EMC85226.1 - 4.4e-10 40.2 0.2 1.2e-09 38.8 0.2 1.6 2 0 0 2 2 2 1 STIMATE family SVM_signal PF12113.8 EMC85226.1 - 0.6 10.1 3.6 0.36 10.8 0.7 1.9 2 0 0 2 2 2 0 SVM protein signal sequence MBT PF02820.18 EMC85227.1 - 2.5e-91 300.0 0.6 1.7e-22 79.6 0.0 4.5 4 0 0 4 4 4 4 mbt repeat SLED PF12140.8 EMC85227.1 - 9.3e-40 135.6 0.0 2.2e-39 134.4 0.0 1.7 1 0 0 1 1 1 1 SLED domain SAM_1 PF00536.30 EMC85227.1 - 4.6e-10 39.8 0.0 8.5e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC85227.1 - 7.1e-07 29.2 0.0 2e-06 27.8 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 EMC85227.1 - 0.00064 19.6 0.0 0.0014 18.5 0.0 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_Ste50p PF09235.10 EMC85227.1 - 0.0072 16.5 0.0 0.018 15.3 0.0 1.6 1 0 0 1 1 1 1 Ste50p, sterile alpha motif Agenet PF05641.12 EMC85227.1 - 0.037 14.5 0.5 5 7.7 0.0 3.5 3 0 0 3 3 3 0 Agenet domain DUF4637 PF15470.6 EMC85227.1 - 5.2 6.8 9.4 12 5.6 9.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Rft-1 PF04506.13 EMC85228.1 - 1.4e-115 387.0 18.7 1.5e-115 386.9 18.7 1.0 1 0 0 1 1 1 1 Rft protein Phtf-FEM1B_bdg PF12129.8 EMC85228.1 - 0.43 10.4 5.3 0.35 10.7 3.3 1.9 2 0 0 2 2 2 0 Male germ-cell putative homeodomain transcription factor Pkinase PF00069.25 EMC85229.1 - 2e-34 119.2 0.0 3.3e-34 118.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC85229.1 - 1.4e-31 109.7 0.0 2.4e-31 109.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Activin_recp PF01064.23 EMC85229.1 - 6.1e-06 27.2 12.5 6.1e-06 27.2 12.5 2.2 2 0 0 2 2 2 1 Activin types I and II receptor domain Pkinase_fungal PF17667.1 EMC85229.1 - 2.1e-05 23.5 0.0 3.7e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 EMC85229.1 - 0.029 14.0 0.0 0.18 11.4 0.0 2.0 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EMC85229.1 - 0.054 13.4 0.0 0.093 12.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family ORC4_C PF14629.6 EMC85230.1 - 4e-50 170.2 2.9 6.3e-50 169.6 2.9 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 EMC85230.1 - 1.5e-13 51.4 2.0 2.5e-13 50.8 0.6 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EMC85230.1 - 7.1e-09 36.1 0.5 2.4e-08 34.3 0.3 2.0 2 0 0 2 2 1 1 AAA domain AAA PF00004.29 EMC85230.1 - 7.2e-09 36.2 0.3 1.7e-08 34.9 0.1 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EMC85230.1 - 4.6e-08 33.3 0.3 1e-07 32.1 0.2 1.6 2 0 0 2 2 1 1 ATPase domain predominantly from Archaea NACHT PF05729.12 EMC85230.1 - 1e-07 32.0 1.9 2.3e-06 27.6 1.9 2.7 1 1 0 1 1 1 1 NACHT domain AAA_19 PF13245.6 EMC85230.1 - 4.7e-05 23.8 0.1 0.00046 20.6 0.0 2.3 2 1 0 2 2 2 1 AAA domain DUF815 PF05673.13 EMC85230.1 - 0.00052 19.3 0.2 0.00086 18.5 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 EMC85230.1 - 0.00056 19.9 0.1 0.002 18.2 0.1 2.1 1 1 0 1 1 1 1 AAA domain DAP3 PF10236.9 EMC85230.1 - 0.0011 18.2 2.7 0.1 11.8 0.2 2.4 2 0 0 2 2 2 2 Mitochondrial ribosomal death-associated protein 3 AAA_21 PF13304.6 EMC85230.1 - 0.0011 18.8 0.2 0.084 12.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EMC85230.1 - 0.0054 16.2 0.1 1.5 8.2 0.0 2.3 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain T2SSE PF00437.20 EMC85230.1 - 0.0069 15.5 0.1 0.012 14.7 0.1 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_7 PF12775.7 EMC85230.1 - 0.024 14.2 0.0 0.096 12.2 0.0 2.0 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF2075 PF09848.9 EMC85230.1 - 0.03 13.6 0.2 0.058 12.6 0.1 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TrwB_AAD_bind PF10412.9 EMC85230.1 - 0.034 13.1 0.1 0.072 12.0 0.1 1.5 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain cobW PF02492.19 EMC85230.1 - 0.035 13.7 0.0 0.076 12.6 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 EMC85230.1 - 0.055 13.2 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 EMC85230.1 - 0.062 13.5 0.0 0.18 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EMC85230.1 - 0.065 13.5 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF3399 PF11879.8 EMC85230.1 - 0.075 13.4 0.2 0.21 11.9 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3399) TniB PF05621.11 EMC85230.1 - 0.082 12.3 1.6 0.59 9.5 0.0 2.6 3 0 0 3 3 3 0 Bacterial TniB protein Alpha_kinase PF02816.18 EMC85230.1 - 0.1 12.7 1.2 0.59 10.2 0.1 2.2 2 0 0 2 2 2 0 Alpha-kinase family TBPIP PF07106.13 EMC85230.1 - 0.14 12.2 0.1 1.3 9.0 0.0 2.8 2 1 0 2 2 2 0 TBPIP/Hop2 winged helix domain ABC_tran PF00005.27 EMC85230.1 - 0.28 11.7 1.1 0.73 10.3 1.0 2.0 1 1 0 1 1 1 0 ABC transporter DUF3958 PF13125.6 EMC85230.1 - 0.4 10.9 0.1 0.4 10.9 0.1 2.8 3 0 0 3 3 2 0 Protein of unknown function (DUF3958) PWWP PF00855.17 EMC85231.1 - 4.2e-07 30.3 0.1 1.7e-06 28.3 0.1 2.1 1 1 0 1 1 1 1 PWWP domain MBD PF01429.19 EMC85231.1 - 0.036 13.8 0.0 0.11 12.3 0.0 1.7 1 0 0 1 1 1 0 Methyl-CpG binding domain Kinesin PF00225.23 EMC85232.1 - 9.7e-111 369.9 0.3 9.7e-111 369.9 0.3 2.4 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EMC85232.1 - 1e-22 80.7 0.0 1e-22 80.7 0.0 3.7 3 1 0 3 3 3 1 Microtubule binding DASH_Dam1 PF08653.10 EMC85232.1 - 0.37 10.6 12.4 3.3 7.6 0.6 4.7 3 0 0 3 3 3 0 DASH complex subunit Dam1 PTSIIB_sorb PF03830.15 EMC85232.1 - 1 9.6 8.2 1.8 8.8 0.1 3.9 3 0 0 3 3 3 0 PTS system sorbose subfamily IIB component UPAR_LY6_2 PF16975.5 EMC85233.1 - 2.5e-54 182.0 16.3 3.1e-54 181.7 16.3 1.1 1 0 0 1 1 1 1 Ly6/PLAUR domain-containing protein 6, Lypd6 UPAR_LY6_2 PF16975.5 EMC85234.1 - 3.6e-47 159.0 15.4 8e-47 157.8 15.4 1.5 1 1 0 1 1 1 1 Ly6/PLAUR domain-containing protein 6, Lypd6 MMADHC PF10229.9 EMC85235.1 - 2.5e-131 437.4 0.0 2.8e-131 437.2 0.0 1.0 1 0 0 1 1 1 1 Methylmalonic aciduria and homocystinuria type D protein Ras PF00071.22 EMC85236.1 - 6.9e-43 146.0 0.0 9.2e-43 145.6 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC85236.1 - 6.6e-19 68.3 0.0 1.2e-18 67.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC85236.1 - 8.2e-07 28.6 0.0 1.2e-06 28.0 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EMC85236.1 - 0.019 14.4 0.0 0.056 12.9 0.0 1.7 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit TniB PF05621.11 EMC85236.1 - 0.027 13.9 0.0 0.045 13.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein PduV-EutP PF10662.9 EMC85236.1 - 0.098 12.4 0.0 0.71 9.6 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_14 PF13173.6 EMC85236.1 - 0.13 12.3 0.0 0.22 11.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EMC85236.1 - 0.15 12.4 0.0 0.27 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Ribosomal_L32p PF01783.23 EMC85236.1 - 2.4 8.5 5.7 24 5.3 0.0 3.2 3 1 1 4 4 4 0 Ribosomal L32p protein family NID PF07292.13 EMC85237.1 - 9.5e-13 48.6 0.2 1.3e-06 28.9 0.0 2.6 2 0 0 2 2 2 2 Nmi/IFP 35 domain (NID) RRM_1 PF00076.22 EMC85237.1 - 0.0018 18.1 0.0 0.0035 17.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NID PF07292.13 EMC85238.1 - 2.2e-59 198.1 0.0 2.7e-30 104.8 0.1 2.1 2 0 0 2 2 2 2 Nmi/IFP 35 domain (NID) DUF237 PF03072.14 EMC85238.1 - 0.013 15.5 0.0 0.023 14.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF237) Nup35_RRM_2 PF14605.6 EMC85238.1 - 0.094 12.7 0.0 62 3.7 0.0 3.2 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif CUB PF00431.20 EMC85239.1 - 1.4e-36 125.1 0.1 2.4e-36 124.4 0.1 1.4 1 0 0 1 1 1 1 CUB domain Xlink PF00193.17 EMC85239.1 - 9e-30 102.9 0.3 1.5e-29 102.2 0.3 1.4 1 0 0 1 1 1 1 Extracellular link domain Rif1_N PF12231.8 EMC85240.1 - 3.4e-76 256.7 6.0 3.4e-76 256.7 6.0 1.8 2 0 0 2 2 2 1 Rap1-interacting factor 1 N terminal Arf PF00025.21 EMC85241.1 - 1e-64 217.2 0.8 1.2e-64 216.9 0.8 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EMC85241.1 - 2.7e-15 56.6 0.3 3.7e-15 56.2 0.3 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMC85241.1 - 3.9e-14 52.6 0.4 4.2e-14 52.5 0.4 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EMC85241.1 - 2.5e-12 46.6 0.3 3e-12 46.3 0.3 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EMC85241.1 - 5.8e-09 35.6 1.2 1.7e-06 27.4 0.5 2.4 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 EMC85241.1 - 3.3e-07 30.4 0.2 4.6e-07 29.9 0.2 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMC85241.1 - 6.7e-07 28.9 0.4 8e-07 28.6 0.4 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EMC85241.1 - 0.0036 16.9 0.4 0.018 14.6 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_14 PF13173.6 EMC85241.1 - 0.02 14.9 0.2 0.1 12.6 0.0 1.9 1 1 1 2 2 2 0 AAA domain FeoB_N PF02421.18 EMC85241.1 - 0.042 13.4 0.9 0.2 11.2 0.8 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B TPM_phosphatase PF04536.14 EMC85241.1 - 0.081 13.1 0.2 0.19 11.9 0.1 1.7 1 1 1 2 2 2 0 TPM domain TniB PF05621.11 EMC85241.1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Guanylate_kin PF00625.21 EMC85242.1 - 1.4e-47 161.8 0.2 2.3e-47 161.0 0.2 1.4 1 0 0 1 1 1 1 Guanylate kinase VGCC_beta4Aa_N PF12052.8 EMC85242.1 - 1.7e-22 79.2 6.3 4.1e-22 78.0 6.3 1.7 1 0 0 1 1 1 1 Voltage gated calcium channel subunit beta domain 4Aa N terminal SH3_1 PF00018.28 EMC85242.1 - 0.0013 18.3 0.0 0.0054 16.3 0.0 2.0 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EMC85242.1 - 0.052 13.2 0.0 0.13 11.9 0.0 1.7 1 0 0 1 1 1 0 Variant SH3 domain SH3_9 PF14604.6 EMC85242.1 - 0.18 11.7 0.0 0.37 10.7 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain VHS PF00790.19 EMC85243.1 - 4.3e-39 133.6 1.6 3.6e-38 130.6 0.1 2.4 2 0 0 2 2 2 1 VHS domain SH3_1 PF00018.28 EMC85243.1 - 7.7e-19 67.0 0.1 1.4e-18 66.2 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC85243.1 - 4e-12 45.8 0.1 7.5e-12 44.9 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC85243.1 - 4.9e-12 45.3 0.0 8.4e-12 44.6 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain UIM PF02809.20 EMC85243.1 - 1.7e-05 24.4 2.0 4.4e-05 23.1 2.0 1.8 1 0 0 1 1 1 1 Ubiquitin interaction motif DUF4527 PF15030.6 EMC85243.1 - 0.089 12.2 6.1 0.13 11.6 0.5 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4527) PIN_8 PF18476.1 EMC85243.1 - 0.38 10.6 4.7 3.5 7.4 0.1 2.6 2 0 0 2 2 2 0 PIN like domain FH2 PF02181.23 EMC85244.1 - 7.7e-107 357.6 11.9 7.7e-107 357.6 11.9 3.3 5 0 0 5 5 5 2 Formin Homology 2 Domain Drf_FH3 PF06367.16 EMC85244.1 - 1.2e-49 168.6 16.1 1.2e-49 168.6 16.1 2.8 2 1 1 3 3 3 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 EMC85244.1 - 2.7e-23 82.5 21.0 2.4e-13 50.1 0.5 5.4 4 1 1 5 5 5 2 Diaphanous GTPase-binding Domain PRIMA1 PF16101.5 EMC85244.1 - 0.0074 16.3 1.0 0.019 15.0 1.0 1.6 1 0 0 1 1 1 1 Proline-rich membrane anchor 1 DsrC PF04358.13 EMC85244.1 - 0.34 11.4 3.6 0.57 10.7 1.5 2.5 2 0 0 2 2 2 0 DsrC like protein PT PF04886.12 EMC85245.1 - 0.012 15.2 3.8 7.7 6.2 0.0 3.5 2 1 0 2 2 2 0 PT repeat FF PF01846.19 EMC85246.1 - 7.1e-47 157.4 23.7 3.6e-16 59.1 0.5 6.2 5 0 0 5 5 5 5 FF domain WW PF00397.26 EMC85246.1 - 2e-19 69.3 19.5 3e-10 40.0 8.0 2.6 2 0 0 2 2 2 2 WW domain Glyco_hyd_101C PF17451.2 EMC85246.1 - 0.9 9.8 13.7 4.8 7.5 2.5 3.9 2 1 1 3 3 3 0 Glycosyl hydrolase 101 beta sandwich domain LUD_dom PF02589.15 EMC85246.1 - 1.8 8.2 7.2 1.5 8.5 1.2 3.1 3 0 0 3 3 3 0 LUD domain IRK_C PF17655.1 EMC85247.1 - 2.4e-50 170.5 0.0 3.4e-50 170.0 0.0 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain DAO PF01266.24 EMC85249.1 - 8.6e-53 180.1 0.0 1.2e-52 179.7 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 EMC85249.1 - 3.7e-42 143.2 0.1 7.6e-42 142.1 0.1 1.6 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase EF-hand_7 PF13499.6 EMC85249.1 - 3.4e-12 46.6 0.3 7.6e-12 45.5 0.3 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EMC85249.1 - 1.3e-10 40.0 0.5 8.2e-05 21.9 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EMC85249.1 - 1e-09 37.5 0.3 0.00015 21.4 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain FAD_binding_2 PF00890.24 EMC85249.1 - 1.6e-08 34.1 0.3 4.2e-06 26.1 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EMC85249.1 - 5.6e-07 29.1 0.2 0.00078 18.8 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EMC85249.1 - 8.3e-07 28.7 0.2 6.6e-06 25.7 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EMC85249.1 - 2.4e-06 26.9 0.0 0.00062 19.0 0.1 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A EF-hand_8 PF13833.6 EMC85249.1 - 1.4e-05 24.8 0.0 3.7e-05 23.5 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EMC85249.1 - 0.00011 21.5 0.9 0.2 11.2 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 EMC85249.1 - 0.00021 21.6 0.0 0.00064 20.0 0.0 1.9 2 0 0 2 2 1 1 EF-hand domain HI0933_like PF03486.14 EMC85249.1 - 0.0058 15.4 0.1 0.0091 14.7 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.6 EMC85249.1 - 0.0061 16.8 0.5 0.036 14.3 0.1 2.5 3 0 0 3 3 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EMC85249.1 - 0.0067 15.7 0.0 0.063 12.5 0.0 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMC85249.1 - 0.018 15.6 0.1 0.072 13.6 0.1 2.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EMC85249.1 - 0.035 13.3 0.1 0.19 10.9 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain Thi4 PF01946.17 EMC85249.1 - 0.058 12.6 0.0 0.16 11.2 0.0 1.7 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 EMC85249.1 - 0.11 11.5 0.2 3.3 6.7 0.1 2.3 2 0 0 2 2 2 0 Lycopene cyclase protein Dmrt1 PF12374.8 EMC85250.1 - 0.046 14.2 0.2 0.046 14.2 0.2 2.0 2 0 0 2 2 2 0 Double-sex mab3 related transcription factor 1 PDZ PF00595.24 EMC85251.1 - 5.9e-10 39.4 0.0 1.3e-09 38.2 0.0 1.6 1 1 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC85251.1 - 1.4e-08 34.4 0.0 2.9e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC85251.1 - 0.0026 18.1 0.0 0.0045 17.3 0.0 1.3 1 0 0 1 1 1 1 PDZ domain Pkinase_Tyr PF07714.17 EMC85252.1 - 2.4e-36 125.4 0.0 3.6e-36 124.8 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC85252.1 - 4.5e-36 124.6 0.0 6.6e-36 124.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.12 EMC85252.1 - 2.4e-16 58.9 0.4 4.7e-16 58.0 0.4 1.5 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Pkinase_fungal PF17667.1 EMC85252.1 - 0.00035 19.5 0.0 0.00063 18.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMC85252.1 - 0.00066 19.7 0.0 0.008 16.1 0.0 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EMC85252.1 - 0.0016 17.4 0.1 0.0032 16.5 0.1 1.5 1 1 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 EMC85252.1 - 0.016 14.9 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 DUF4398 PF14346.6 EMC85253.1 - 0.037 14.6 1.7 16 6.2 0.1 3.2 2 1 0 3 3 3 0 Domain of unknown function (DUF4398) TILa PF12714.7 EMC85253.1 - 0.093 12.7 3.0 49 4.0 0.0 4.1 3 2 2 5 5 5 0 TILa domain FAM110_N PF14161.6 EMC85253.1 - 0.25 11.6 5.5 28 5.0 0.1 3.5 1 1 2 3 3 3 0 Centrosome-associated N terminus Keratin_B2_2 PF13885.6 EMC85255.1 - 1.7e-06 27.9 97.5 1.8e+02 2.2 25.1 5.9 1 1 2 3 3 3 1 Keratin, high sulfur B2 protein Arm PF00514.23 EMC85256.1 - 2e-45 151.5 6.9 5.4e-10 39.0 0.0 9.1 9 0 0 9 9 9 7 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EMC85256.1 - 2.8e-06 27.6 0.1 0.04 14.3 0.0 2.8 2 0 0 2 2 2 2 HEAT repeats HEAT PF02985.22 EMC85256.1 - 0.00056 19.9 5.4 0.94 9.9 0.0 5.1 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 EMC85256.1 - 0.00082 19.8 1.4 1.4 9.5 0.0 4.6 4 0 0 4 4 4 1 HEAT-like repeat DAP PF15228.6 EMC85257.1 - 3.1e-11 44.3 2.9 5.5e-11 43.5 2.9 1.4 1 1 0 1 1 1 1 Death-associated protein Ank_2 PF12796.7 EMC85260.1 - 5.7e-56 187.1 1.0 1.7e-13 50.9 0.0 5.0 2 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC85260.1 - 6.9e-43 144.5 10.9 1.2e-07 32.1 0.0 7.9 3 2 6 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC85260.1 - 2.1e-32 107.5 1.3 0.0009 19.5 0.0 9.9 10 0 0 10 10 9 6 Ankyrin repeat Ank_5 PF13857.6 EMC85260.1 - 1.1e-30 105.2 4.5 7.8e-10 38.8 0.0 7.5 3 2 4 8 8 7 4 Ankyrin repeats (many copies) Ank PF00023.30 EMC85260.1 - 4.2e-29 99.7 12.9 0.0014 19.0 0.0 10.1 11 0 0 11 11 10 6 Ankyrin repeat TPR_2 PF07719.17 EMC85260.1 - 3.1e-07 30.0 7.9 0.4 10.9 0.3 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_9 PF13371.6 EMC85260.1 - 2.2e-05 24.5 1.8 0.00072 19.7 0.8 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EMC85260.1 - 3.5e-05 24.3 2.9 0.001 19.6 0.0 3.0 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMC85260.1 - 0.0002 21.0 4.5 1.4 8.6 0.1 3.5 3 0 0 3 3 3 3 TPR repeat TPR_8 PF13181.6 EMC85260.1 - 0.00021 21.3 3.9 0.037 14.2 0.0 2.9 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMC85260.1 - 0.00049 20.6 6.6 0.28 11.7 1.6 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMC85260.1 - 0.0032 17.2 7.4 4 7.4 1.3 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 EMC85260.1 - 0.0088 16.4 2.8 3 8.4 0.4 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat AAA_16 PF13191.6 EMC85260.1 - 0.022 15.1 0.2 0.022 15.1 0.2 3.1 2 2 0 2 2 2 0 AAA ATPase domain TPR_12 PF13424.6 EMC85260.1 - 0.041 14.2 0.2 0.041 14.2 0.2 3.0 3 1 0 3 3 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 EMC85260.1 - 0.097 12.7 0.2 6.5 7.0 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EMC85260.1 - 0.49 11.3 10.3 0.019 15.8 2.8 2.8 2 0 0 2 2 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC85260.1 - 6.2 7.1 6.2 1.7 8.9 2.7 1.9 2 0 0 2 2 1 0 Anaphase-promoting complex, cyclosome, subunit 3 WD40 PF00400.32 EMC85261.1 - 2.2e-42 142.2 17.2 4e-07 30.6 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat U-box PF04564.15 EMC85261.1 - 6e-23 80.8 0.1 1.2e-22 79.9 0.1 1.5 1 0 0 1 1 1 1 U-box domain SAM_2 PF07647.17 EMC85261.1 - 2.8e-14 53.0 0.2 4.8e-14 52.2 0.2 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EMC85261.1 - 3.2e-12 46.7 0.2 7.3e-12 45.6 0.2 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) ANAPC4_WD40 PF12894.7 EMC85261.1 - 5e-11 42.8 0.0 0.061 13.6 0.0 4.8 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMC85261.1 - 3.7e-06 26.1 6.5 0.015 14.3 0.7 4.4 2 2 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein SAM_PNT PF02198.16 EMC85261.1 - 1.2e-05 25.1 0.0 2.7e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Frtz PF11768.8 EMC85261.1 - 3.5e-05 22.3 0.0 0.056 11.8 0.0 2.2 2 0 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz eIF2A PF08662.11 EMC85261.1 - 6.5e-05 22.9 0.0 0.27 11.1 0.0 3.0 2 1 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A PALB2_WD40 PF16756.5 EMC85261.1 - 0.00062 18.8 0.2 0.24 10.3 0.1 2.4 2 0 0 2 2 2 2 Partner and localizer of BRCA2 WD40 domain zf-NOSIP PF15906.5 EMC85261.1 - 0.00098 19.2 1.6 0.0028 17.8 0.0 2.5 3 0 0 3 3 2 1 Zinc-finger of nitric oxide synthase-interacting protein SAM_3 PF18016.1 EMC85261.1 - 0.0026 17.5 0.2 0.0077 16.0 0.2 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-Nse PF11789.8 EMC85261.1 - 0.0067 16.2 0.1 0.021 14.7 0.0 1.8 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit ELYS-bb PF16687.5 EMC85261.1 - 0.037 12.7 0.0 0.06 12.0 0.0 1.3 1 0 0 1 1 1 0 beta-propeller of ELYS nucleoporin DUF2850 PF11012.8 EMC85261.1 - 0.053 13.8 0.0 8.8 6.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2850) MNNL PF07657.13 EMC85261.1 - 0.19 11.8 2.8 0.28 11.2 0.2 2.3 2 0 0 2 2 2 0 N terminus of Notch ligand DUF2415 PF10313.9 EMC85261.1 - 6 6.9 6.1 29 4.7 0.0 4.0 4 0 0 4 4 4 0 Uncharacterised protein domain (DUF2415) Collagen PF01391.18 EMC85263.1 - 6.5e-15 54.6 84.8 4e-09 36.1 37.6 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Presenilin PF01080.17 EMC85263.1 - 0.39 9.4 5.4 0.45 9.2 5.4 1.1 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 EMC85263.1 - 0.7 9.8 20.9 0.78 9.7 20.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Raftlin PF15250.6 EMC85263.1 - 1.5 7.5 7.4 1.8 7.2 7.4 1.1 1 0 0 1 1 1 0 Raftlin Lin-8 PF03353.15 EMC85263.1 - 9.6 5.7 6.8 12 5.3 6.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist RINGv PF12906.7 EMC85264.1 - 2.6e-15 56.2 8.0 5.3e-15 55.3 8.0 1.5 1 0 0 1 1 1 1 RING-variant domain FANCL_C PF11793.8 EMC85264.1 - 0.00031 20.9 4.2 0.00031 20.9 4.2 1.7 2 0 0 2 2 2 1 FANCL C-terminal domain zf-RING_2 PF13639.6 EMC85264.1 - 0.0016 18.7 5.3 0.0032 17.8 5.3 1.5 1 0 0 1 1 1 1 Ring finger domain DUF1139 PF06599.11 EMC85264.1 - 0.22 10.9 0.1 6.9 6.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1139) COesterase PF00135.28 EMC85266.1 - 2.4e-18 66.3 0.0 2.6e-18 66.2 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family TTL PF03133.15 EMC85268.1 - 1.2e-79 267.5 0.3 3.7e-79 265.9 0.3 1.8 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_ST PF14397.6 EMC85268.1 - 2.6e-07 30.2 0.0 0.02 14.2 0.0 2.3 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATPgrasp_YheCD PF14398.6 EMC85268.1 - 3.2e-07 29.9 3.3 0.00059 19.2 0.0 3.3 3 1 1 4 4 4 2 YheC/D like ATP-grasp ATP-grasp_3 PF02655.14 EMC85268.1 - 0.00089 19.3 0.0 0.0035 17.4 0.0 2.0 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 EMC85268.1 - 0.053 13.1 0.0 3.1 7.4 0.0 2.3 2 0 0 2 2 2 0 RimK-like ATP-grasp domain GTP-bdg_M PF16360.5 EMC85268.1 - 0.28 11.8 9.9 0.041 14.5 4.6 2.4 2 0 0 2 2 2 0 GTP-binding GTPase Middle Region Pkinase PF00069.25 EMC85269.1 - 2.7e-73 246.6 0.0 3.3e-73 246.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC85269.1 - 8e-35 120.4 0.0 1.1e-34 119.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC85269.1 - 9e-09 35.0 0.0 2e-08 33.9 0.0 1.6 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EMC85269.1 - 0.019 13.9 0.2 0.057 12.3 0.1 1.6 1 1 0 2 2 2 0 Haspin like kinase domain APH PF01636.23 EMC85269.1 - 0.048 13.6 0.1 1.8 8.4 0.0 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family SAM_1 PF00536.30 EMC85270.1 - 8.9e-10 38.9 0.0 1.1e-09 38.5 0.0 1.1 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC85270.1 - 4.9e-05 23.4 0.0 7.2e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 EMC85270.1 - 8.4e-05 22.5 0.0 9.7e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Uricase PF01014.18 EMC85271.1 - 2.7e-46 157.1 0.0 5.2e-26 91.4 0.0 2.0 2 0 0 2 2 2 2 Uricase zf-SCNM1 PF15803.5 EMC85271.1 - 0.013 15.2 0.1 0.032 13.9 0.1 1.7 1 0 0 1 1 1 0 Zinc-finger of sodium channel modifier 1 Albumin_I PF08027.11 EMC85271.1 - 0.053 13.1 0.7 0.17 11.6 0.7 1.8 1 0 0 1 1 1 0 Albumin I chain b DNase_II PF03265.15 EMC85272.1 - 4.4e-108 361.4 1.8 4.9e-108 361.2 1.8 1.0 1 0 0 1 1 1 1 Deoxyribonuclease II PX PF00787.24 EMC85272.1 - 0.15 12.1 0.4 1.8 8.6 0.0 2.5 2 1 0 2 2 2 0 PX domain Brix PF04427.18 EMC85273.1 - 3.6e-24 85.9 0.2 4.5e-24 85.6 0.2 1.1 1 0 0 1 1 1 1 Brix domain G-gamma PF00631.22 EMC85274.1 - 3.9e-09 36.4 0.0 4.1e-09 36.3 0.0 1.0 1 0 0 1 1 1 1 GGL domain SPATA1_C PF15743.5 EMC85275.1 - 1.8e-51 174.2 29.7 5.2e-51 172.7 29.7 1.8 1 0 0 1 1 1 1 Spermatogenesis-associated C-terminus YxiJ PF14176.6 EMC85275.1 - 0.13 12.7 0.4 0.13 12.7 0.4 2.6 2 0 0 2 2 2 0 YxiJ-like protein PH_9 PF15410.6 EMC85275.1 - 1 9.8 5.1 3.7 7.9 5.1 2.0 1 1 0 1 1 1 0 Pleckstrin homology domain Glyco_hydro_18 PF00704.28 EMC85276.1 - 4.9e-33 115.2 0.0 6.3e-33 114.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 7tm_1 PF00001.21 EMC85277.1 - 2.8e-34 118.6 23.8 4.7e-34 117.9 23.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC85277.1 - 0.0036 17.1 18.1 0.011 15.4 18.1 1.8 1 1 0 1 1 1 1 Olfactory receptor TMEM192 PF14802.6 EMC85277.1 - 0.083 12.0 5.0 0.025 13.7 1.7 1.8 2 0 0 2 2 2 0 TMEM192 family PKD_channel PF08016.12 EMC85278.1 - 4.5e-11 42.1 9.6 7e-11 41.5 9.6 1.3 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.31 EMC85278.1 - 0.00023 20.5 18.9 0.00049 19.4 18.9 1.5 1 1 0 1 1 1 1 Ion transport protein DUF4522 PF15022.6 EMC85278.1 - 0.0072 16.6 0.1 0.018 15.3 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF4522) PKD_channel PF08016.12 EMC85279.1 - 2.9e-11 42.7 12.9 2.9e-11 42.7 12.9 1.6 1 1 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.31 EMC85279.1 - 0.0012 18.1 25.5 0.0031 16.8 25.5 1.7 1 1 0 1 1 1 1 Ion transport protein WD40 PF00400.32 EMC85280.1 - 0.0063 17.3 14.2 0.12 13.2 0.0 5.5 6 0 0 6 6 6 2 WD domain, G-beta repeat CARD PF00619.21 EMC85281.1 - 1.7e-15 56.8 0.3 2.6e-15 56.2 0.3 1.3 1 0 0 1 1 1 1 Caspase recruitment domain CARD_2 PF16739.5 EMC85281.1 - 0.0015 18.5 0.1 0.0024 17.8 0.1 1.3 1 0 0 1 1 1 1 Caspase recruitment domain TetR_C_8 PF14278.6 EMC85281.1 - 0.11 12.6 0.0 0.3 11.2 0.0 1.7 2 0 0 2 2 2 0 Transcriptional regulator C-terminal region Amidinotransf PF02274.17 EMC85282.1 - 4.8e-05 22.6 0.0 0.0001 21.5 0.0 1.6 1 1 0 1 1 1 1 Amidinotransferase TTRAP PF14203.6 EMC85282.1 - 0.65 10.0 2.9 2.1 8.4 0.0 2.7 3 0 0 3 3 3 0 Putative tranposon-transfer assisting protein Cys_knot PF00007.22 EMC85283.1 - 8.9e-16 58.1 12.6 8.9e-16 58.1 12.6 3.2 3 1 0 3 3 3 1 Cystine-knot domain VWC PF00093.18 EMC85283.1 - 3.6e-10 40.0 12.8 3.6e-10 40.0 12.8 5.0 3 1 2 5 5 5 1 von Willebrand factor type C domain TSP_1 PF00090.19 EMC85283.1 - 4.1e-05 23.7 7.4 4.1e-05 23.7 7.4 4.2 5 1 0 5 5 5 1 Thrombospondin type 1 domain zf-HIT PF04438.16 EMC85284.1 - 7.2e-05 22.6 12.6 7.2e-05 22.6 12.6 1.9 2 0 0 2 2 2 1 HIT zinc finger Sep15_SelM PF08806.11 EMC85285.1 - 1.5e-17 63.5 0.0 1.6e-17 63.4 0.0 1.0 1 0 0 1 1 1 1 Sep15/SelM redox domain zf-H2C2_2 PF13465.6 EMC85291.1 - 5.2e-19 67.8 33.7 1.6e-06 28.3 0.2 6.1 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2 PF00096.26 EMC85291.1 - 5.7e-16 58.0 44.9 1e-05 25.7 0.4 6.5 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC85291.1 - 3.5e-10 39.8 41.8 0.0002 21.9 0.4 6.6 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EMC85291.1 - 0.0057 16.4 0.2 0.0057 16.4 0.2 4.4 4 0 0 4 4 4 1 zinc-finger C2H2-type zf-H2C2_5 PF13909.6 EMC85291.1 - 0.0062 16.3 0.1 0.0062 16.3 0.1 5.2 5 0 0 5 5 5 2 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 EMC85291.1 - 0.012 15.9 25.4 0.44 10.9 0.0 5.8 5 1 1 6 6 6 0 Zinc-finger double-stranded RNA-binding GAGA PF09237.11 EMC85291.1 - 0.11 12.3 0.1 0.11 12.3 0.1 2.5 2 1 1 3 3 3 0 GAGA factor zf-met PF12874.7 EMC85291.1 - 0.25 11.8 0.1 0.25 11.8 0.1 5.8 6 0 0 6 6 6 0 Zinc-finger of C2H2 type RNA_POL_M_15KD PF02150.16 EMC85291.1 - 0.49 10.3 11.4 6.4 6.7 0.0 5.2 6 0 0 6 6 6 0 RNA polymerases M/15 Kd subunit zf-RING_7 PF02591.15 EMC85291.1 - 1.9 8.7 9.2 65 3.8 0.0 4.9 5 0 0 5 5 5 0 C4-type zinc ribbon domain zinc_ribbon_5 PF13719.6 EMC85291.1 - 6.7 6.6 12.7 0.3 10.9 0.3 3.6 4 0 0 4 4 4 0 zinc-ribbon domain zf-RRPl_C4 PF17026.5 EMC85291.1 - 8.5 6.5 10.3 0.87 9.7 1.2 3.1 3 0 0 3 3 3 0 Putative ribonucleoprotein zinc-finger pf C4 type zf-C2HE PF16278.5 EMC85291.1 - 10 6.7 22.2 0.85 10.1 0.7 4.9 4 1 1 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger AAA PF00004.29 EMC85292.1 - 1e-37 129.5 0.0 1.8e-37 128.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EMC85292.1 - 1.1e-07 31.7 0.0 4e-07 29.9 0.0 2.0 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 EMC85292.1 - 2.4e-07 30.4 0.0 6.7e-07 29.0 0.0 1.8 1 1 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 EMC85292.1 - 0.00015 21.6 0.0 0.00028 20.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EMC85292.1 - 0.0027 17.7 0.1 0.015 15.3 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EMC85292.1 - 0.0037 17.4 0.0 0.0078 16.3 0.0 1.5 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EMC85292.1 - 0.0045 17.3 0.4 0.53 10.6 0.2 3.0 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.6 EMC85292.1 - 0.007 16.8 2.9 0.39 11.1 0.2 2.9 2 1 0 3 3 3 1 AAA ATPase domain TIP49 PF06068.13 EMC85292.1 - 0.032 13.4 0.1 0.073 12.3 0.1 1.5 1 1 0 1 1 1 0 TIP49 P-loop domain AAA_11 PF13086.6 EMC85292.1 - 0.073 12.8 0.1 3.9 7.2 0.0 2.5 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EMC85292.1 - 0.084 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 EMC85292.1 - 0.15 11.5 0.1 0.33 10.3 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Pyridoxal_deC PF00282.19 EMC85293.1 - 1.3e-167 557.3 0.0 1.5e-167 557.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EMC85293.1 - 0.00023 20.6 0.0 0.00038 19.9 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EMC85293.1 - 0.0013 18.0 0.0 0.0028 16.9 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class I and II Pyridoxal_deC PF00282.19 EMC85294.1 - 2.4e-164 546.5 0.0 2.9e-164 546.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EMC85294.1 - 0.0059 15.9 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase WH2 PF02205.20 EMC85295.1 - 3e-14 52.3 4.2 0.00022 20.9 0.1 3.6 3 0 0 3 3 3 3 WH2 motif PRIMA1 PF16101.5 EMC85295.1 - 2.8 8.0 14.5 0.09 12.8 6.5 2.5 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 V-set PF07686.17 EMC85297.1 - 2.8e-10 40.3 0.1 5.3e-10 39.4 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC85297.1 - 1e-08 35.6 0.1 3.3e-08 34.0 0.1 1.9 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC85297.1 - 2e-08 34.3 0.1 5.1e-08 33.0 0.1 1.6 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC85297.1 - 3.3e-08 33.5 1.8 4.8e-07 29.7 1.8 2.3 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC85297.1 - 0.0024 18.2 0.1 1.6 9.1 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Acyl-CoA_dh_1 PF00441.24 EMC85299.1 - 1.1e-10 41.9 0.7 1.3e-10 41.6 0.7 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain MORN PF02493.20 EMC85300.1 - 6.8e-09 35.1 4.5 12 6.0 0.0 6.9 6 1 1 7 7 7 5 MORN repeat zf_CCCH_4 PF18345.1 EMC85300.1 - 0.0048 16.9 10.0 1.8e+02 2.4 0.1 8.0 6 0 0 6 6 6 0 Zinc finger domain MORN PF02493.20 EMC85301.1 - 2.2e-11 43.0 4.6 9.5 6.3 0.0 7.4 7 0 0 7 7 7 6 MORN repeat zf_CCCH_4 PF18345.1 EMC85301.1 - 0.0035 17.3 11.3 1.4e+02 2.7 0.1 7.8 6 0 0 6 6 6 0 Zinc finger domain HutP PF09021.11 EMC85301.1 - 9.6 6.5 20.1 1.1e+02 3.1 0.2 5.8 1 1 4 5 5 5 0 HutP ACBP PF00887.19 EMC85303.1 - 1.6e-24 85.9 0.3 1.7e-24 85.8 0.3 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein MDH PF02315.16 EMC85303.1 - 0.0018 18.3 0.1 0.0018 18.3 0.1 1.1 1 0 0 1 1 1 1 Methanol dehydrogenase beta subunit Pkinase PF00069.25 EMC85304.1 - 1.6e-70 237.5 0.0 1.9e-70 237.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC85304.1 - 5.5e-34 117.6 0.0 7.5e-34 117.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC85304.1 - 0.0027 17.1 0.1 0.023 14.0 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EMC85304.1 - 0.034 12.9 0.0 0.052 12.3 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EMC85304.1 - 0.16 11.8 0.6 4.8 7.0 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family FH2 PF02181.23 EMC85305.1 - 1.6e-10 40.7 0.8 2.5e-10 40.0 0.8 1.3 1 0 0 1 1 1 1 Formin Homology 2 Domain Myosin_head PF00063.21 EMC85306.1 - 3.4e-238 792.3 8.9 4e-238 792.0 8.9 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EMC85306.1 - 3.2e-45 154.1 0.2 7.9e-45 152.8 0.2 1.7 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.27 EMC85306.1 - 0.0096 15.6 0.7 0.0096 15.6 0.7 3.3 3 0 0 3 3 3 1 IQ calmodulin-binding motif AAA_18 PF13238.6 EMC85306.1 - 0.024 15.2 0.0 0.15 12.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EMC85306.1 - 0.029 13.7 0.0 0.085 12.1 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.6 EMC85306.1 - 0.045 14.0 0.0 0.14 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EMC85306.1 - 0.082 13.3 0.0 0.28 11.6 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain CDK5_activator PF03261.15 EMC85307.1 - 6.5e-59 200.3 0.2 8.8e-59 199.9 0.2 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase 5 activator protein RPN6_N PF18055.1 EMC85308.1 - 1.7e-31 109.0 0.2 1.7e-31 109.0 0.2 3.1 3 1 0 3 3 3 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 EMC85308.1 - 1.3e-20 73.8 0.8 1.3e-20 73.8 0.8 2.3 3 0 0 3 3 3 1 PCI domain RPN6_C_helix PF18503.1 EMC85308.1 - 1.3e-16 60.0 1.2 3.1e-16 58.8 1.2 1.7 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_12 PF13424.6 EMC85308.1 - 0.00083 19.6 14.3 0.0057 16.9 2.9 4.5 4 1 0 4 4 4 2 Tetratricopeptide repeat DDRGK PF09756.9 EMC85308.1 - 0.0061 16.2 0.7 0.0096 15.5 0.2 1.6 2 0 0 2 2 2 1 DDRGK domain DUF2153 PF09921.9 EMC85308.1 - 0.046 13.5 0.7 0.15 11.9 0.6 1.9 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2153) SbsC_C PF18058.1 EMC85308.1 - 0.19 11.9 2.7 0.29 11.4 0.4 2.4 2 0 0 2 2 2 0 SbsC C-terminal domain TPR_2 PF07719.17 EMC85308.1 - 0.23 11.7 6.9 15 6.0 0.1 5.1 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 EMC85308.1 - 0.89 9.7 5.0 19 5.6 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 EMC85308.1 - 1.3 9.0 5.8 9.7 6.2 0.1 4.4 3 2 2 5 5 5 0 Tetratricopeptide repeat Frizzled PF01534.17 EMC85309.1 - 3e-136 453.7 18.1 4.2e-136 453.3 18.1 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 EMC85309.1 - 7.2e-34 116.7 3.8 1.6e-33 115.6 3.8 1.6 1 0 0 1 1 1 1 Fz domain Integrin_alpha2 PF08441.12 EMC85310.1 - 7.9e-37 127.2 0.0 9.3e-37 127.0 0.0 1.0 1 0 0 1 1 1 1 Integrin alpha GCIP PF13324.6 EMC85311.1 - 2.8e-08 33.7 0.0 3.2e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting FAM163 PF15069.6 EMC85311.1 - 0.0049 17.3 0.1 0.0053 17.2 0.1 1.3 1 0 0 1 1 1 1 FAM163 family Cadherin_C_2 PF16492.5 EMC85311.1 - 0.019 15.7 0.0 0.029 15.1 0.0 1.4 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal RhoGAP PF00620.27 EMC85312.1 - 6.2e-40 136.5 0.0 3.1e-38 131.0 0.0 2.6 2 1 0 2 2 2 1 RhoGAP domain WW PF00397.26 EMC85312.1 - 3.2e-17 62.3 16.3 6.3e-09 35.8 0.6 3.4 3 0 0 3 3 3 2 WW domain PH PF00169.29 EMC85312.1 - 1.9e-08 34.8 0.5 3.8e-08 33.8 0.0 1.8 2 0 0 2 2 2 1 PH domain PH_9 PF15410.6 EMC85312.1 - 6.6e-08 33.0 0.1 1.2e-07 32.1 0.1 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain SH3_9 PF14604.6 EMC85312.1 - 0.00045 20.0 0.0 0.0012 18.7 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC85312.1 - 0.0011 18.6 0.0 0.0027 17.3 0.0 1.7 1 0 0 1 1 1 1 SH3 domain Glyco_hyd_101C PF17451.2 EMC85312.1 - 0.1 12.9 0.5 1.1 9.6 0.1 2.4 2 0 0 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain zf-RING_9 PF13901.6 EMC85313.1 - 5.3e-41 140.9 9.5 5.9e-41 140.7 9.5 1.0 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon C1_1 PF00130.22 EMC85313.1 - 0.0061 16.4 12.3 0.13 12.2 12.5 2.4 1 1 1 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 EMC85313.1 - 0.16 11.9 12.4 0.77 9.7 9.2 3.0 2 1 0 2 2 2 0 PHD-finger Prok-RING_1 PF14446.6 EMC85313.1 - 0.18 11.7 13.9 0.9 9.5 13.9 2.2 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 zf-UDP PF14569.6 EMC85313.1 - 0.29 11.3 9.5 0.69 10.1 9.5 1.8 1 1 0 1 1 1 0 Zinc-binding RING-finger Zn_Tnp_IS91 PF14319.6 EMC85313.1 - 7 6.8 16.3 6.8 6.8 5.5 2.6 2 1 0 2 2 2 0 Transposase zinc-binding domain C1_2 PF03107.16 EMC85313.1 - 9.3 6.7 17.6 49 4.4 13.2 3.0 2 1 0 2 2 2 0 C1 domain RUN PF02759.19 EMC85314.1 - 1.1e-25 90.1 0.1 1.8e-25 89.5 0.1 1.3 1 0 0 1 1 1 1 RUN domain Hormone_1 PF00103.20 EMC85315.1 - 2.9e-44 151.4 0.0 3.3e-44 151.2 0.0 1.0 1 0 0 1 1 1 1 Somatotropin hormone family XTBD PF11952.8 EMC85315.1 - 0.04 13.7 0.1 0.4 10.5 0.0 2.5 3 0 0 3 3 3 0 XRN-Two Binding Domain, XTBD I-set PF07679.16 EMC85316.1 - 4.7e-06 26.6 0.0 7.6e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC85316.1 - 0.00036 21.1 0.0 0.00061 20.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC85316.1 - 0.00056 20.1 1.0 0.0039 17.3 1.0 2.0 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 EMC85316.1 - 0.093 12.9 0.2 0.16 12.1 0.2 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Syndecan PF01034.20 EMC85316.1 - 0.22 11.4 1.9 0.75 9.8 0.0 2.5 3 0 0 3 3 3 0 Syndecan domain Tmemb_9 PF05434.11 EMC85317.1 - 0.061 13.2 0.1 0.077 12.9 0.1 1.1 1 0 0 1 1 1 0 TMEM9 DUF1072 PF06380.11 EMC85317.1 - 0.33 10.9 7.6 1 9.3 1.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1072) Ephrin_rec_like PF07699.13 EMC85318.1 - 5e-05 23.0 0.3 0.00011 21.9 0.3 1.7 1 0 0 1 1 1 1 Putative ephrin-receptor like 7TM_GPCR_Srh PF10318.9 EMC85318.1 - 0.044 12.8 0.2 0.048 12.7 0.2 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srh DCP2 PF05026.13 EMC85318.1 - 0.076 13.3 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 Dcp2, box A domain Ig_2 PF13895.6 EMC85319.1 - 4.3e-05 23.8 0.0 9.8e-05 22.6 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain Sp38 PF07354.12 EMC85319.1 - 0.00043 19.8 0.3 0.00063 19.2 0.3 1.2 1 0 0 1 1 1 1 Zona-pellucida-binding protein (Sp38) Ig_3 PF13927.6 EMC85319.1 - 0.00063 20.3 0.0 0.0013 19.3 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin domain Izumo-Ig PF16706.5 EMC85319.1 - 0.00074 19.5 0.0 0.0015 18.6 0.0 1.4 1 0 0 1 1 1 1 Izumo-like Immunoglobulin domain ig PF00047.25 EMC85319.1 - 0.0012 19.0 0.0 0.0028 17.8 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC85319.1 - 0.0031 17.6 0.1 0.0091 16.2 0.0 1.7 1 1 1 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.16 EMC85319.1 - 0.0082 16.2 0.0 0.017 15.2 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_6 PF18452.1 EMC85319.1 - 0.069 12.7 0.0 0.15 11.6 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain 7tm_2 PF00002.24 EMC85320.1 - 2.4e-75 253.0 21.9 3.3e-75 252.6 21.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 EMC85320.1 - 5.2e-17 61.9 1.8 1.1e-16 60.8 1.8 1.6 1 0 0 1 1 1 1 Hormone receptor domain DUF2976 PF11190.8 EMC85320.1 - 0.2 11.5 1.4 18 5.2 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) DUF4574 PF15141.6 EMC85320.1 - 0.22 11.4 0.3 21 5.1 0.1 2.6 1 1 1 2 2 2 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 ASC PF00858.24 EMC85321.1 - 6.3e-27 94.6 0.0 7e-27 94.5 0.0 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel PT PF04886.12 EMC85322.1 - 5.1e-08 32.3 0.1 0.027 14.0 0.0 3.9 2 2 1 3 3 3 2 PT repeat ASC PF00858.24 EMC85323.1 - 3e-43 148.4 0.6 2e-33 116.1 0.1 2.0 1 1 1 2 2 2 2 Amiloride-sensitive sodium channel Acyltransferase PF01553.21 EMC85325.1 - 2.5e-12 46.6 0.0 2.8e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 Acyltransferase Acyltransferase PF01553.21 EMC85326.1 - 1.5e-12 47.3 0.1 1.7e-12 47.1 0.1 1.0 1 0 0 1 1 1 1 Acyltransferase DUF4587 PF15248.6 EMC85327.1 - 1.5e-16 61.0 1.6 1.1e-11 45.4 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4587) 7tm_2 PF00002.24 EMC85328.1 - 1e-84 283.7 18.8 1.6e-84 283.1 18.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 EMC85328.1 - 1.3e-15 57.4 1.5 1.3e-15 57.4 1.5 2.2 3 0 0 3 3 3 1 Hormone receptor domain DUF4418 PF14387.6 EMC85328.1 - 0.015 15.5 1.0 0.015 15.5 1.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4418) DUF2628 PF10947.8 EMC85328.1 - 0.78 10.1 9.9 0.38 11.1 6.9 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2628) UAA PF08449.11 EMC85329.1 - 5.9e-43 147.2 2.3 7.1e-43 146.9 2.3 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 EMC85329.1 - 9.4e-13 48.5 14.7 1.7e-09 38.0 9.5 2.0 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 EMC85329.1 - 1.4e-12 47.6 5.2 1.4e-08 34.5 0.6 2.0 2 0 0 2 2 2 2 Triose-phosphate Transporter family CRT-like PF08627.10 EMC85329.1 - 0.00025 20.1 2.2 0.014 14.4 0.0 2.0 1 1 0 2 2 2 2 CRT-like, chloroquine-resistance transporter-like Nuc_sug_transp PF04142.15 EMC85329.1 - 0.0047 16.1 0.6 0.049 12.8 0.6 2.0 1 1 0 1 1 1 1 Nucleotide-sugar transporter BTB PF00651.31 EMC85330.1 - 1.1e-33 115.7 1.7 4.6e-33 113.8 0.3 2.1 1 1 1 2 2 2 1 BTB/POZ domain MATH PF00917.26 EMC85330.1 - 3.4e-07 30.4 0.2 1e-06 28.9 0.1 1.9 2 0 0 2 2 2 1 MATH domain BACK PF07707.15 EMC85330.1 - 0.0011 19.0 0.9 0.1 12.7 0.0 3.3 4 0 0 4 4 4 1 BTB And C-terminal Kelch Neurexophilin PF06312.12 EMC85331.1 - 5e-104 346.3 0.6 6.3e-104 346.0 0.6 1.1 1 0 0 1 1 1 1 Neurexophilin Filamin PF00630.19 EMC85331.1 - 0.0093 16.8 0.2 0.56 11.1 0.0 2.2 1 1 1 2 2 2 1 Filamin/ABP280 repeat TNFR_c6 PF00020.18 EMC85332.1 - 1.5e-27 95.7 47.7 7.9e-12 45.4 7.7 4.4 3 1 0 4 4 4 4 TNFR/NGFR cysteine-rich region DUF3762 PF12591.8 EMC85332.1 - 0.029 14.6 0.4 0.073 13.3 0.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3762) Band_7 PF01145.25 EMC85333.1 - 2.1e-08 34.4 3.0 2.8e-08 34.0 2.9 1.3 1 1 0 1 1 1 1 SPFH domain / Band 7 family Med2 PF11214.8 EMC85333.1 - 0.0026 17.9 0.7 0.0038 17.3 0.7 1.2 1 0 0 1 1 1 1 Mediator complex subunit 2 DUF4290 PF14123.6 EMC85333.1 - 0.057 13.0 0.0 0.069 12.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4290) G-gamma PF00631.22 EMC85334.1 - 4.3e-18 65.1 0.0 4.7e-18 65.0 0.0 1.0 1 0 0 1 1 1 1 GGL domain DUF3294 PF07957.11 EMC85334.1 - 0.037 13.8 1.1 0.041 13.6 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3294) KH_1 PF00013.29 EMC85335.1 - 4e-58 193.1 12.0 4.3e-14 52.1 0.1 4.5 4 0 0 4 4 4 4 KH domain KH_2 PF07650.17 EMC85335.1 - 6.5e-19 67.5 3.3 0.0012 18.6 0.1 4.6 4 0 0 4 4 4 4 KH domain KH_4 PF13083.6 EMC85335.1 - 4.1e-16 58.6 1.2 0.0044 16.9 0.0 5.1 5 0 0 5 5 5 4 KH domain KH_5 PF13184.6 EMC85335.1 - 1.2e-08 34.9 3.9 0.37 10.9 0.1 4.4 4 0 0 4 4 4 3 NusA-like KH domain RRM_1 PF00076.22 EMC85335.1 - 2.7e-08 33.5 0.0 5.8e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MOEP19 PF16005.5 EMC85335.1 - 9.6e-08 31.9 0.2 0.056 13.4 0.0 4.3 4 0 0 4 4 4 2 KH-like RNA-binding domain RRM_occluded PF16842.5 EMC85335.1 - 0.01 15.6 0.0 0.049 13.5 0.0 2.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif RRM_5 PF13893.6 EMC85335.1 - 0.02 14.5 0.2 0.087 12.4 0.1 2.0 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Hormone_2 PF00123.20 EMC85336.1 - 3.2e-08 33.3 0.1 3.2e-08 33.3 0.1 1.8 2 0 0 2 2 2 1 Peptide hormone EAP30 PF04157.16 EMC85337.1 - 4.3e-74 248.8 0.1 5e-74 248.6 0.1 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family ZapD PF07072.11 EMC85337.1 - 0.029 14.1 1.6 11 5.8 0.0 3.0 3 0 0 3 3 3 0 Cell division protein Plasmid_RAQPRD PF09686.10 EMC85337.1 - 0.057 13.6 0.1 0.14 12.3 0.1 1.6 1 0 0 1 1 1 0 Plasmid protein of unknown function (Plasmid_RAQPRD) L27_2 PF09045.10 EMC85337.1 - 0.15 12.1 1.3 0.54 10.3 0.0 2.4 3 0 0 3 3 3 0 L27_2 EutK_C PF16365.5 EMC85337.1 - 0.16 12.0 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilization protein EutK C-terminus Phage_Mu_Gam PF07352.12 EMC85337.1 - 1.7 8.6 5.6 0.32 10.9 0.9 2.1 3 0 0 3 3 3 0 Bacteriophage Mu Gam like protein UQ_con PF00179.26 EMC85338.1 - 8.1e-30 103.3 0.0 1.6e-29 102.3 0.1 1.5 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EMC85338.1 - 0.00027 20.8 1.9 0.0011 18.8 0.0 2.4 2 1 0 3 3 3 1 UEV domain Prok-E2_B PF14461.6 EMC85338.1 - 0.028 14.1 0.0 0.049 13.3 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 EMC85338.1 - 0.087 13.1 0.0 0.2 12.0 0.0 1.6 1 0 0 1 1 1 0 RWD domain UFC1 PF08694.11 EMC85338.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 SKICH PF17751.1 EMC85339.1 - 8.9e-34 116.1 0.7 1.7e-33 115.2 0.7 1.5 1 0 0 1 1 1 1 SKICH domain Zn-C2H2_12 PF18112.1 EMC85339.1 - 5.7e-07 29.9 11.6 6.3e-06 26.5 0.5 2.7 2 0 0 2 2 2 1 Autophagy receptor zinc finger-C2H2 domain KASH_CCD PF14662.6 EMC85339.1 - 1.8e-05 24.7 31.5 3.2e-05 23.8 31.5 1.4 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH HOOK PF05622.12 EMC85339.1 - 0.00022 19.5 26.6 0.00031 19.0 26.6 1.2 1 0 0 1 1 1 1 HOOK protein zf-C2H2_4 PF13894.6 EMC85339.1 - 0.0014 19.3 6.2 1.4 9.9 2.6 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger GAS PF13851.6 EMC85339.1 - 0.0023 17.3 34.5 0.1 11.9 9.2 2.2 2 0 0 2 2 2 2 Growth-arrest specific micro-tubule binding EMP24_GP25L PF01105.24 EMC85339.1 - 0.0037 17.2 1.0 0.0037 17.2 1.0 3.7 1 1 2 3 3 3 1 emp24/gp25L/p24 family/GOLD bZIP_1 PF00170.21 EMC85339.1 - 0.005 16.9 2.1 0.005 16.9 2.1 3.8 3 1 0 3 3 3 1 bZIP transcription factor ZapB PF06005.12 EMC85339.1 - 0.0073 16.7 44.5 0.37 11.3 6.5 3.6 1 1 2 3 3 3 3 Cell division protein ZapB DUF4407 PF14362.6 EMC85339.1 - 0.0082 15.5 8.4 0.013 14.8 8.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) zf-C2HC_2 PF13913.6 EMC85339.1 - 0.05 13.5 1.4 1.1 9.2 0.1 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Prok-RING_4 PF14447.6 EMC85339.1 - 0.18 11.7 6.0 11 6.0 0.2 3.7 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 DUF1825 PF08855.10 EMC85339.1 - 0.19 11.7 3.0 0.61 10.0 2.9 1.9 2 0 0 2 2 1 0 Domain of unknown function (DUF1825) ADIP PF11559.8 EMC85339.1 - 0.2 11.7 35.6 0.07 13.2 10.3 2.7 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding TSC22 PF01166.18 EMC85339.1 - 0.25 11.7 32.0 0.51 10.7 6.8 4.2 1 1 3 4 4 4 0 TSC-22/dip/bun family CENP-F_leu_zip PF10473.9 EMC85339.1 - 0.3 11.1 38.0 0.095 12.7 23.2 2.4 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF5082 PF16888.5 EMC85339.1 - 0.54 10.5 19.9 1.8 8.8 12.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) TMF_TATA_bd PF12325.8 EMC85339.1 - 0.54 10.5 33.1 1.2 9.4 15.5 3.1 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF1664 PF07889.12 EMC85339.1 - 0.69 10.0 14.2 1.1 9.3 4.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) CALCOCO1 PF07888.11 EMC85339.1 - 0.71 8.7 29.1 1 8.1 29.1 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like UBZ_FAAP20 PF15750.5 EMC85339.1 - 0.97 9.4 5.2 0.63 10.0 1.8 2.3 1 1 1 2 2 2 0 Ubiquitin-binding zinc-finger BLOC1_2 PF10046.9 EMC85339.1 - 1 9.7 22.1 1.1 9.6 12.3 2.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Ax_dynein_light PF10211.9 EMC85339.1 - 1.1 9.1 28.8 0.15 12.0 4.6 3.1 1 1 2 3 3 3 0 Axonemal dynein light chain TcpS PF17456.2 EMC85339.1 - 1.7 8.7 8.1 3.3 7.7 7.3 2.0 1 1 0 1 1 1 0 Toxin-coregulated pilus protein S STAT_alpha PF01017.20 EMC85339.1 - 2.5 8.0 21.5 16 5.3 19.3 2.5 1 1 0 1 1 1 0 STAT protein, all-alpha domain CENP-H PF05837.12 EMC85339.1 - 2.7 8.4 32.2 1.4 9.4 10.5 3.2 1 1 2 3 3 3 0 Centromere protein H (CENP-H) YabA PF06156.13 EMC85339.1 - 2.9 8.6 31.4 9.5 6.9 4.6 3.5 1 1 2 3 3 3 0 Initiation control protein YabA zf-C2H2 PF00096.26 EMC85339.1 - 3 8.5 7.2 14 6.4 0.5 3.2 2 1 0 2 2 2 0 Zinc finger, C2H2 type HAP1_N PF04849.13 EMC85339.1 - 3.1 6.9 34.8 1.8 7.7 19.5 2.3 1 1 0 1 1 1 0 HAP1 N-terminal conserved region LMBR1 PF04791.16 EMC85339.1 - 3.3 6.5 6.7 5.5 5.8 6.7 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein WD40_alt PF14077.6 EMC85339.1 - 3.7 7.5 20.2 0.6 10.0 3.6 3.8 3 1 0 4 4 3 0 Alternative WD40 repeat motif Spc7 PF08317.11 EMC85339.1 - 6 5.7 34.9 2.7 6.8 18.4 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF848 PF05852.11 EMC85339.1 - 6.4 6.9 22.9 0.38 10.8 5.2 2.6 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) GOLGA2L5 PF15070.6 EMC85339.1 - 6.4 5.3 29.2 11 4.5 29.2 1.3 1 0 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 ERM PF00769.19 EMC85339.1 - 6.8 6.4 33.2 6.5 6.5 15.2 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF4795 PF16043.5 EMC85339.1 - 7 6.2 25.9 0.27 10.8 4.5 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) DUF3450 PF11932.8 EMC85339.1 - 7.3 5.8 28.0 2.3 7.5 6.3 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) Noelin-1 PF12308.8 EMC85339.1 - 8.3 6.5 14.5 0.18 11.8 3.2 2.5 1 1 1 2 2 2 0 Neurogenesis glycoprotein FUSC PF04632.12 EMC85339.1 - 8.3 4.8 8.5 12 4.3 8.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family TPR_MLP1_2 PF07926.12 EMC85339.1 - 8.7 6.4 36.8 6.8 6.8 9.0 3.2 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein DivIC PF04977.15 EMC85339.1 - 8.7 6.2 34.1 1.4 8.7 3.0 4.9 2 2 3 5 5 5 0 Septum formation initiator ATG16 PF08614.11 EMC85339.1 - 8.9 6.5 38.5 6.2 7.0 10.3 2.4 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Homeodomain PF00046.29 EMC85340.1 - 1.1e-19 70.0 5.3 1.2e-19 69.9 5.3 1.0 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC85340.1 - 0.00015 21.6 3.8 0.00018 21.3 3.8 1.4 1 1 0 1 1 1 1 Homeobox KN domain CI-B14_5a PF07347.12 EMC85340.1 - 0.015 15.2 0.1 0.016 15.1 0.1 1.1 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) DUF1510 PF07423.11 EMC85340.1 - 0.056 13.6 0.0 0.059 13.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1510) Homez PF11569.8 EMC85340.1 - 0.11 12.0 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Hox9_act PF04617.13 EMC85341.1 - 1.6e-58 198.5 4.7 2.5e-58 197.9 4.7 1.3 1 0 0 1 1 1 1 Hox9 activation region Homeodomain PF00046.29 EMC85341.1 - 6.5e-21 73.9 6.3 1.1e-20 73.2 6.3 1.4 1 0 0 1 1 1 1 Homeodomain HTH_23 PF13384.6 EMC85341.1 - 0.0037 17.0 0.0 0.007 16.1 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain Homeobox_KN PF05920.11 EMC85341.1 - 0.065 13.2 0.3 0.15 12.0 0.3 1.6 1 0 0 1 1 1 0 Homeobox KN domain Homeodomain PF00046.29 EMC85342.1 - 5.9e-22 77.3 5.7 1.1e-21 76.5 5.7 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC85342.1 - 0.0046 16.8 0.1 0.011 15.6 0.1 1.7 1 0 0 1 1 1 1 Homeobox KN domain MRP-63 PF14978.6 EMC85342.1 - 0.061 14.0 3.3 0.098 13.3 3.3 1.4 1 0 0 1 1 1 0 Mitochondrial ribosome protein 63 Homeodomain PF00046.29 EMC85343.1 - 7.4e-22 77.0 8.1 1.1e-21 76.4 8.1 1.3 1 0 0 1 1 1 1 Homeodomain DUF2209 PF09974.9 EMC85343.1 - 0.057 13.8 0.1 0.078 13.3 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Homeodomain PF00046.29 EMC85344.1 - 5.3e-22 77.4 8.5 8.3e-22 76.8 8.5 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC85344.1 - 0.1 12.5 0.6 0.25 11.3 0.6 1.7 1 0 0 1 1 1 0 Homeobox KN domain DUF2209 PF09974.9 EMC85344.1 - 0.17 12.2 0.1 0.25 11.7 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Homeodomain PF00046.29 EMC85345.1 - 3.6e-22 77.9 8.4 7e-22 77.0 8.4 1.5 1 0 0 1 1 1 1 Homeodomain DUF2209 PF09974.9 EMC85345.1 - 0.08 13.3 0.1 0.12 12.7 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) DUF739 PF05339.11 EMC85345.1 - 0.1 12.8 0.1 0.22 11.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF739) Homeobox_KN PF05920.11 EMC85345.1 - 0.22 11.4 2.7 0.23 11.4 0.8 2.1 2 0 0 2 2 2 0 Homeobox KN domain Homeodomain PF00046.29 EMC85346.1 - 2.6e-22 78.4 8.4 2.6e-22 78.4 8.4 1.6 2 0 0 2 2 2 1 Homeodomain DUF2209 PF09974.9 EMC85346.1 - 0.027 14.8 0.1 0.042 14.2 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Homeobox_KN PF05920.11 EMC85346.1 - 0.098 12.6 0.8 0.22 11.5 0.4 1.8 2 0 0 2 2 2 0 Homeobox KN domain DUF4074 PF13293.6 EMC85347.1 - 6.6e-35 119.2 10.9 6.6e-35 119.2 10.9 3.1 3 1 0 3 3 3 1 Domain of unknown function (DUF4074) Homeodomain PF00046.29 EMC85347.1 - 1e-08 34.9 11.9 0.00018 21.3 0.3 2.8 2 1 1 3 3 3 2 Homeodomain Homeodomain PF00046.29 EMC85348.1 - 5.2e-22 77.4 7.2 8.1e-22 76.8 7.2 1.3 1 0 0 1 1 1 1 Homeodomain YcgR PF07317.12 EMC85348.1 - 0.082 12.8 0.0 1.2 9.1 0.0 2.1 1 1 1 2 2 2 0 Flagellar regulator YcgR Homeobox_KN PF05920.11 EMC85348.1 - 0.11 12.4 0.6 0.11 12.4 0.6 2.3 2 0 0 2 2 2 0 Homeobox KN domain Loricrin PF15847.5 EMC85349.1 - 0.0047 16.1 26.9 0.14 11.3 5.0 3.1 1 1 2 3 3 3 3 Major keratinocyte cell envelope protein DUF2314 PF10077.9 EMC85349.1 - 0.21 11.7 0.0 87 3.2 0.0 3.4 1 1 2 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2314) PH PF00169.29 EMC85350.1 - 4.5e-12 46.4 1.2 5e-12 46.3 1.2 1.0 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EMC85350.1 - 7.9e-05 23.0 0.8 9.4e-05 22.8 0.8 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 EMC85350.1 - 0.022 14.9 0.0 0.025 14.7 0.0 1.2 1 0 0 1 1 1 0 PH domain PH_15 PF17339.2 EMC85350.1 - 0.13 12.1 0.2 0.17 11.8 0.2 1.4 1 1 0 1 1 1 0 PH domain Chromo_shadow PF01393.19 EMC85351.1 - 9.4e-34 115.3 0.1 7.4e-31 106.0 0.0 2.4 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.24 EMC85351.1 - 7.1e-22 77.1 3.8 1.8e-18 66.2 0.4 3.0 3 0 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.6 EMC85351.1 - 0.0014 18.8 0.2 0.01 16.0 0.2 2.0 2 0 0 2 2 2 1 Polycomb-like MTF2 factor 2 ELM2 PF01448.24 EMC85351.1 - 0.84 10.4 5.9 1.7 9.4 0.8 2.6 2 1 0 2 2 2 0 ELM2 domain Clat_adaptor_s PF01217.20 EMC85352.1 - 4.4e-25 88.3 0.0 4.8e-25 88.1 0.0 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF5392 PF17370.2 EMC85352.1 - 0.065 13.3 0.0 0.073 13.2 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5392) DUF773 PF05600.12 EMC85353.1 - 1.8e-37 129.3 0.0 2e-37 129.1 0.0 1.0 1 0 0 1 1 1 1 CDK5 regulatory subunit-associated protein 3 Peptidase_C69 PF03577.15 EMC85355.1 - 2.6e-07 29.9 0.0 3.3e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C69 AAT PF03417.16 EMC85355.1 - 0.12 12.0 0.0 2.8 7.5 0.0 2.2 2 0 0 2 2 2 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase LRR_4 PF12799.7 EMC85356.1 - 6.4e-12 45.5 5.9 3.2e-05 24.2 0.1 2.8 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC85356.1 - 2.6e-09 36.8 0.0 3.6e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 EMC85356.1 - 8.1e-09 35.1 5.4 5.1e-06 26.2 0.7 2.7 3 0 0 3 3 3 2 Leucine rich repeat LRR_6 PF13516.6 EMC85356.1 - 6.7e-06 25.7 2.0 0.005 16.8 0.1 3.6 3 0 0 3 3 3 1 Leucine Rich repeat LRR_1 PF00560.33 EMC85356.1 - 0.0061 16.9 4.7 0.42 11.3 0.8 3.6 2 1 0 2 2 2 1 Leucine Rich Repeat HEPN_RES_NTD1 PF18870.1 EMC85356.1 - 0.1 12.8 0.0 0.15 12.3 0.0 1.1 1 0 0 1 1 1 0 HEPN/RES N-terminal domain 1 T-box PF00907.22 EMC85357.1 - 1.9e-30 106.5 0.4 6.8e-26 91.7 0.0 2.2 1 1 1 2 2 2 2 T-box HEAT PF02985.22 EMC85358.1 - 2.1e-18 64.8 6.6 4.1e-05 23.5 0.0 9.6 9 0 0 9 9 9 3 HEAT repeat HEAT_EZ PF13513.6 EMC85358.1 - 1e-15 57.8 4.1 2.5e-11 43.8 0.0 6.5 7 1 1 8 8 8 1 HEAT-like repeat IBN_N PF03810.19 EMC85358.1 - 1.5e-10 40.8 0.6 1.8e-09 37.4 0.0 3.0 2 1 0 2 2 2 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 EMC85358.1 - 1.6e-08 34.8 0.2 0.00079 19.8 0.0 5.3 2 2 3 5 5 5 3 HEAT repeats Arm PF00514.23 EMC85358.1 - 1.3e-07 31.4 6.4 0.0031 17.5 0.0 5.1 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 EMC85358.1 - 2.2e-05 24.6 3.8 0.014 15.5 0.0 3.6 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 EMC85358.1 - 5.6e-05 22.8 3.4 0.48 9.9 0.0 4.3 3 1 1 4 4 4 2 CLASP N terminal MMS19_C PF12460.8 EMC85358.1 - 0.0058 15.8 7.5 0.44 9.6 0.2 3.5 4 1 0 5 5 5 2 RNAPII transcription regulator C-terminal V-ATPase_H_C PF11698.8 EMC85358.1 - 0.77 9.9 8.4 0.6 10.2 0.3 3.6 4 0 0 4 4 4 0 V-ATPase subunit H Peptidase_M1 PF01433.20 EMC85359.1 - 1.8e-92 308.8 0.5 2.8e-92 308.2 0.5 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 EMC85359.1 - 4.5e-79 266.2 0.0 3.1e-78 263.5 0.0 2.1 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EMC85359.1 - 1.5e-51 175.2 0.1 2.8e-51 174.4 0.1 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Tim44 PF04280.15 EMC85360.1 - 5.9e-32 110.8 0.0 7.7e-32 110.4 0.0 1.2 1 0 0 1 1 1 1 Tim44-like domain MBA1 PF07961.11 EMC85360.1 - 0.001 18.2 0.0 0.0017 17.5 0.0 1.3 1 0 0 1 1 1 1 MBA1-like protein ChaB PF06150.12 EMC85360.1 - 0.0094 16.5 0.1 0.018 15.6 0.1 1.5 1 0 0 1 1 1 1 ChaB Kri1 PF05178.12 EMC85360.1 - 0.13 12.8 0.4 0.23 12.0 0.4 1.3 1 0 0 1 1 1 0 KRI1-like family TMEM191C PF15194.6 EMC85361.1 - 0.019 15.1 8.3 4.5 7.5 0.3 3.4 1 1 2 3 3 3 0 TMEM191C family Chlorosome_CsmC PF11098.8 EMC85361.1 - 0.081 12.9 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Chlorosome envelope protein C HSA PF07529.13 EMC85361.1 - 0.19 12.1 4.3 24 5.4 1.0 3.4 1 1 3 4 4 4 0 HSA DUF326 PF03860.16 EMC85361.1 - 0.7 9.9 41.3 1.5 8.9 0.7 7.2 6 4 0 6 6 6 0 Domain of Unknown Function (DUF326) IGFBP PF00219.18 EMC85361.1 - 3.6 8.3 40.2 1.7e+03 -0.2 21.0 4.7 1 1 1 2 2 2 0 Insulin-like growth factor binding protein SUI1 PF01253.22 EMC85361.1 - 4.1 8.0 9.6 9.3 6.9 0.6 2.7 1 1 2 3 3 3 0 Translation initiation factor SUI1 NUMOD1 PF07453.13 EMC85362.1 - 2e-11 43.8 15.9 38 4.7 0.0 12.7 8 8 8 16 16 16 8 NUMOD1 domain Colipase-like PF15083.6 EMC85362.1 - 0.15 12.2 39.6 2.7 8.2 5.0 4.4 1 1 3 4 4 4 0 Colipase-like SOCS_box PF07525.16 EMC85363.1 - 6.4e-10 39.2 3.8 6.4e-10 39.2 3.8 1.9 2 0 0 2 2 2 1 SOCS box SH2 PF00017.24 EMC85363.1 - 4.6e-09 36.2 0.0 1.1e-08 35.0 0.0 1.7 1 1 0 1 1 1 1 SH2 domain PDZ_6 PF17820.1 EMC85365.1 - 5.4e-06 26.2 0.1 9.9e-06 25.3 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 EMC85365.1 - 0.021 15.1 0.2 0.034 14.5 0.2 1.3 1 0 0 1 1 1 0 PDZ domain RhoGAP PF00620.27 EMC85366.1 - 3.8e-24 85.2 0.0 4e-24 85.2 0.0 1.0 1 0 0 1 1 1 1 RhoGAP domain AIP3 PF03915.13 EMC85367.1 - 1.1e-13 51.1 1.3 5.2e-09 35.7 0.0 2.5 2 0 0 2 2 2 2 Actin interacting protein 3 Ski_Sno PF02437.17 EMC85368.1 - 0.00075 19.2 0.0 0.0013 18.5 0.0 1.3 1 0 0 1 1 1 1 SKI/SNO/DAC family SPX PF03105.19 EMC85368.1 - 0.38 10.6 12.6 0.57 10.0 12.6 1.4 1 0 0 1 1 1 0 SPX domain zf-HC5HC2H_2 PF13832.6 EMC85369.1 - 7.2e-30 103.4 11.5 1.3e-29 102.6 11.5 1.4 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EMC85369.1 - 1.4e-19 70.1 10.6 3.3e-19 68.9 10.6 1.7 1 0 0 1 1 1 1 PHD-like zinc-binding domain HALZ PF02183.18 EMC85369.1 - 0.005 17.0 2.7 0.005 17.0 2.7 1.8 2 0 0 2 2 2 1 Homeobox associated leucine zipper PHD PF00628.29 EMC85369.1 - 4 7.4 11.2 14 5.7 11.2 2.1 1 0 0 1 1 1 0 PHD-finger DUF2180 PF09947.9 EMC85369.1 - 5.9 6.9 10.1 2.2 8.3 4.9 2.4 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2180) SKA2 PF16740.5 EMC85369.1 - 6.3 6.6 16.2 0.11 12.2 2.2 2.5 2 1 0 2 2 2 0 Spindle and kinetochore-associated protein 2 RAWUL PF16207.5 EMC85371.1 - 4.3e-17 62.6 0.1 6.6e-17 62.0 0.1 1.3 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like Rad60-SLD PF11976.8 EMC85371.1 - 0.031 14.1 0.0 0.052 13.4 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like NosD PF05048.13 EMC85372.1 - 0.042 13.1 0.5 0.3 10.3 0.5 2.2 1 1 0 1 1 1 0 Periplasmic copper-binding protein (NosD) Cornifin PF02389.15 EMC85372.1 - 0.061 13.5 6.2 0.8 9.9 6.2 2.2 1 1 0 1 1 1 0 Cornifin (SPRR) family DUF4033 PF13225.6 EMC85372.1 - 0.4 10.7 51.1 2.8 8.0 3.1 6.0 1 1 4 5 5 5 0 Domain of unknown function (DUF4033) Equine_IAV_S2 PF06502.11 EMC85372.1 - 1.2 9.2 34.7 8.2 6.6 0.1 8.4 1 1 6 8 8 8 0 Equine infectious anaemia virus S2 protein Equine_IAV_S2 PF06502.11 EMC85373.1 - 0.00013 22.0 12.7 2.1 8.5 0.2 5.3 1 1 4 5 5 5 3 Equine infectious anaemia virus S2 protein Peptidase_C36 PF05415.11 EMC85373.1 - 0.00023 21.3 6.7 4.1 7.7 0.1 4.0 1 1 3 4 4 4 3 Beet necrotic yellow vein furovirus-type papain-like endopeptidase DUF4033 PF13225.6 EMC85373.1 - 0.0017 18.3 32.4 1 9.4 2.5 4.8 1 1 3 4 4 4 2 Domain of unknown function (DUF4033) Cornifin PF02389.15 EMC85373.1 - 0.0019 18.4 0.8 0.003 17.8 0.8 1.4 1 1 0 1 1 1 1 Cornifin (SPRR) family NosD PF05048.13 EMC85373.1 - 0.0047 16.2 0.3 0.021 14.1 0.3 1.9 1 1 0 1 1 1 1 Periplasmic copper-binding protein (NosD) Beta_helix PF13229.6 EMC85373.1 - 0.0084 16.0 3.0 0.029 14.2 3.0 1.9 1 1 0 1 1 1 1 Right handed beta helix region Mycobact_memb PF05423.13 EMC85373.1 - 0.017 15.0 10.9 9.5 6.1 0.1 4.0 1 1 3 4 4 4 0 Mycobacterium membrane protein DBD_Tnp_Hermes PF10683.9 EMC85373.1 - 6.4 6.5 12.5 22 4.8 0.8 3.3 1 1 2 3 3 3 0 Hermes transposase DNA-binding domain Endonuclease_5 PF04493.14 EMC85373.1 - 7.4 6.2 13.8 21 4.7 0.4 3.5 1 1 2 3 3 3 0 Endonuclease V Dicty_spore_N PF04562.12 EMC85373.1 - 9.5 7.0 27.5 9.7 6.9 4.4 3.3 1 1 3 4 4 4 0 Dictyostelium spore coat protein, N terminus PIP5K PF01504.18 EMC85374.1 - 1.2e-76 257.6 0.1 1.7e-76 257.1 0.1 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase CWC25 PF12542.8 EMC85375.1 - 3.2e-21 76.1 0.0 3.2e-21 76.1 0.0 4.2 4 1 0 4 4 4 1 Pre-mRNA splicing factor Cir_N PF10197.9 EMC85375.1 - 1.1e-15 57.5 12.1 1.1e-15 57.5 12.1 6.0 6 1 1 7 7 7 1 N-terminal domain of CBF1 interacting co-repressor CIR tRNA-synt_1c PF00749.21 EMC85375.1 - 0.0029 16.5 3.0 0.0029 16.5 3.0 3.1 3 0 0 3 3 3 1 tRNA synthetases class I (E and Q), catalytic domain Tti2 PF10521.9 EMC85375.1 - 1.2 8.6 6.8 3.1 7.2 6.8 1.7 1 0 0 1 1 1 0 Tti2 family Ribosomal_L14 PF00238.19 EMC85376.1 - 4e-36 123.8 0.2 4.7e-36 123.6 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e DUF4064 PF13273.6 EMC85377.1 - 0.0014 18.8 0.6 0.0029 17.9 0.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4064) Ribosomal_L19e PF01280.20 EMC85378.1 - 3e-46 157.1 11.6 3e-46 157.1 11.6 2.0 1 1 1 2 2 2 1 Ribosomal protein L19e DUF1682 PF07946.14 EMC85378.1 - 4.8 6.3 15.6 5.6 6.1 15.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) LRR_4 PF12799.7 EMC85379.1 - 3e-20 72.0 14.7 0.0077 16.6 0.4 6.4 6 0 0 6 6 6 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EMC85379.1 - 1.8e-18 65.0 27.9 0.0032 17.4 0.1 10.6 12 0 0 12 12 12 6 Leucine Rich repeat F-box-like PF12937.7 EMC85379.1 - 3e-13 49.4 0.6 1.1e-12 47.6 0.6 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMC85379.1 - 2.7e-08 33.5 0.7 1.5e-07 31.1 0.7 2.4 1 0 0 1 1 1 1 F-box domain LRR_8 PF13855.6 EMC85379.1 - 1.8e-05 24.4 7.7 0.027 14.2 0.7 5.2 4 3 1 5 5 5 2 Leucine rich repeat LRR_1 PF00560.33 EMC85379.1 - 3.8e-05 23.7 25.8 8.6 7.3 0.2 10.3 11 1 0 11 11 11 3 Leucine Rich Repeat F-box_4 PF15966.5 EMC85379.1 - 0.0052 16.6 2.3 0.012 15.5 0.0 2.7 3 0 0 3 3 3 1 F-box MENTAL PF10457.9 EMC85382.1 - 4.8e-62 208.9 7.2 9.5e-62 208.0 7.2 1.5 1 0 0 1 1 1 1 Cholesterol-capturing domain START PF01852.19 EMC85382.1 - 1e-47 162.3 0.0 1.4e-47 161.8 0.0 1.1 1 0 0 1 1 1 1 START domain LRAT PF04970.13 EMC85383.1 - 1.9e-06 28.2 0.0 2.6e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Lecithin retinol acyltransferase NLPC_P60 PF00877.19 EMC85383.1 - 0.015 15.4 0.0 0.037 14.1 0.0 1.6 2 0 0 2 2 2 0 NlpC/P60 family SIX1_SD PF16878.5 EMC85385.1 - 1.5e-36 125.3 0.4 2e-35 121.7 0.0 2.0 2 0 0 2 2 2 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeodomain PF00046.29 EMC85385.1 - 7.9e-13 48.1 2.8 1.8e-12 46.9 1.2 2.0 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 EMC85385.1 - 7e-11 41.9 0.9 1.7e-10 40.7 0.9 1.6 1 0 0 1 1 1 1 Homeobox KN domain HTH_3 PF01381.22 EMC85385.1 - 0.022 14.8 0.0 0.036 14.1 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix Homez PF11569.8 EMC85385.1 - 0.06 12.8 0.0 0.15 11.6 0.0 1.6 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez CENP-B_N PF04218.13 EMC85385.1 - 0.084 12.5 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_26 PF13443.6 EMC85385.1 - 0.14 12.6 0.0 0.25 11.8 0.0 1.3 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain Methyltransf_16 PF10294.9 EMC85386.1 - 1.8e-16 60.3 0.0 2.2e-16 60.1 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 EMC85386.1 - 0.00091 19.9 0.0 0.0015 19.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC85386.1 - 0.00094 19.8 0.0 0.0016 19.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain FAE1_CUT1_RppA PF08392.12 EMC85386.1 - 0.0021 17.4 0.0 0.003 16.9 0.0 1.2 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein Methyltransf_23 PF13489.6 EMC85386.1 - 0.0029 17.5 0.0 0.0059 16.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC85386.1 - 0.0081 16.9 0.0 0.025 15.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EMC85386.1 - 0.13 11.8 0.1 0.3 10.6 0.1 1.6 1 0 0 1 1 1 0 Methyltransferase small domain Peptidase_S9 PF00326.21 EMC85387.1 - 2.2e-33 115.5 0.0 3.9e-33 114.7 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S9_N PF02897.15 EMC85387.1 - 3.2e-24 85.5 4.2 5.3e-24 84.8 4.2 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Abhydrolase_3 PF07859.13 EMC85387.1 - 0.0011 18.9 0.0 0.0019 18.1 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMC85387.1 - 0.0015 17.8 0.0 0.0026 17.0 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMC85387.1 - 0.012 15.3 0.0 0.043 13.5 0.0 1.8 1 1 0 1 1 1 0 alpha/beta hydrolase fold CARD_2 PF16739.5 EMC85387.1 - 0.056 13.4 0.1 0.38 10.8 0.0 2.3 2 0 0 2 2 2 0 Caspase recruitment domain Alpha-amylase PF00128.24 EMC85388.1 - 9.7e-78 262.1 1.6 1.5e-77 261.4 1.6 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain SLC3A2_N PF16028.5 EMC85388.1 - 1.2e-05 24.7 0.6 2.4e-05 23.8 0.6 1.4 1 0 0 1 1 1 1 Solute carrier family 3 member 2 N-terminus Nup35_RRM_2 PF14605.6 EMC85388.1 - 0.078 13.0 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif PP2C PF00481.21 EMC85389.1 - 1.4e-83 280.4 0.0 1.8e-83 280.1 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_C PF07830.13 EMC85389.1 - 4.9e-31 107.0 0.1 9e-31 106.2 0.1 1.5 1 0 0 1 1 1 1 Protein serine/threonine phosphatase 2C, C-terminal domain PP2C_2 PF13672.6 EMC85389.1 - 0.0021 17.8 0.0 0.0058 16.3 0.0 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EMC85389.1 - 0.0051 16.7 0.0 2.4 8.0 0.0 2.4 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) BLOC1_2 PF10046.9 EMC85390.1 - 5.7e-35 119.5 9.6 7.1e-35 119.2 9.6 1.1 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 ParB PF08775.10 EMC85390.1 - 0.0077 16.7 3.4 0.013 16.0 3.4 1.4 1 0 0 1 1 1 1 ParB family NPV_P10 PF05531.12 EMC85390.1 - 0.036 14.5 0.9 0.061 13.8 0.4 1.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 EMC85390.1 - 0.05 13.9 0.2 0.12 12.7 0.2 1.8 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) XhlA PF10779.9 EMC85390.1 - 0.22 11.8 9.8 0.46 10.7 0.5 3.2 3 1 0 3 3 3 0 Haemolysin XhlA Fib_alpha PF08702.10 EMC85390.1 - 0.24 11.6 4.9 0.29 11.3 4.9 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family CENP-Q PF13094.6 EMC85390.1 - 1.5 9.0 9.2 0.31 11.2 4.8 1.9 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit UPF0449 PF15136.6 EMC85390.1 - 2.4 8.7 6.1 8.7 6.9 1.8 2.1 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 PKD_channel PF08016.12 EMC85391.1 - 1e-159 531.8 19.1 1e-159 531.8 19.1 1.4 2 0 0 2 2 2 1 Polycystin cation channel Ion_trans PF00520.31 EMC85391.1 - 2e-28 99.3 29.0 2e-28 99.3 29.0 1.6 2 0 0 2 2 2 1 Ion transport protein Fer4_24 PF18109.1 EMC85391.1 - 5.7e-17 61.7 1.5 1.2e-16 60.7 1.5 1.6 1 0 0 1 1 1 1 Ferredoxin I 4Fe-4S cluster domain EF-hand_8 PF13833.6 EMC85391.1 - 6e-05 22.8 2.4 0.007 16.2 0.5 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EMC85391.1 - 0.025 14.5 3.1 1.3 9.1 0.1 3.6 4 0 0 4 4 4 0 EF-hand domain Spc7_N PF15402.6 EMC85391.1 - 0.028 12.7 0.7 0.036 12.3 0.7 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 EF-hand_1 PF00036.32 EMC85391.1 - 0.13 11.9 6.7 0.36 10.5 0.2 3.6 4 0 0 4 4 4 0 EF hand DUF1542 PF07564.11 EMC85391.1 - 1 9.5 0.0 1 9.5 0.0 3.3 4 0 0 4 4 4 0 Domain of Unknown Function (DUF1542) EamA PF00892.20 EMC85392.1 - 0.0013 18.9 0.6 0.0013 18.9 0.6 1.0 1 0 0 1 1 1 1 EamA-like transporter family EPTP PF03736.17 EMC85393.1 - 1.1e-72 239.8 21.8 7.1e-13 48.3 0.1 7.2 7 0 0 7 7 7 7 EPTP domain LRR_8 PF13855.6 EMC85393.1 - 3.3e-22 78.0 10.2 5.5e-15 54.9 4.3 2.8 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 EMC85393.1 - 2.3e-09 37.4 6.8 6.5e-05 23.2 2.9 2.7 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC85393.1 - 8.8e-08 32.2 0.5 8.8e-08 32.2 0.5 2.4 3 0 0 3 3 3 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC85393.1 - 0.0049 16.4 0.2 0.019 14.5 0.2 1.6 1 1 0 1 1 1 1 Leucine-rich repeat LRRCT PF01463.24 EMC85393.1 - 0.073 13.6 0.0 0.29 11.8 0.0 2.1 2 0 0 2 2 2 0 Leucine rich repeat C-terminal domain LRR_1 PF00560.33 EMC85393.1 - 0.34 11.6 7.4 2.8 8.8 0.8 3.9 3 0 0 3 3 3 0 Leucine Rich Repeat Fra10Ac1 PF09725.9 EMC85394.1 - 2.5e-53 179.4 6.2 6.7e-53 178.1 6.2 1.8 1 0 0 1 1 1 1 Folate-sensitive fragile site protein Fra10Ac1 DUF755 PF05501.11 EMC85394.1 - 0.0043 17.3 11.6 0.0043 17.3 11.6 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF755) SelP_N PF04592.14 EMC85394.1 - 0.022 14.1 5.1 0.049 13.0 5.1 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region ChAPs PF09295.10 EMC85394.1 - 0.11 11.5 0.0 0.16 10.9 0.0 1.3 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) Phage_holin_2_3 PF16080.5 EMC85394.1 - 0.24 11.2 0.1 0.47 10.2 0.1 1.4 1 0 0 1 1 1 0 Bacteriophage holin family HP1 SpoIIIAH PF12685.7 EMC85394.1 - 0.89 9.3 11.5 0.046 13.5 5.6 1.7 2 0 0 2 2 2 0 SpoIIIAH-like protein PriA_CRR PF18319.1 EMC85394.1 - 1.1 9.3 3.4 0.46 10.5 0.7 1.8 2 0 0 2 2 2 0 PriA DNA helicase Cys-rich region (CRR) domain Eapp_C PF10238.9 EMC85394.1 - 5.3 7.1 10.8 0.13 12.4 3.6 2.0 2 1 0 2 2 2 0 E2F-associated phosphoprotein NPR3 PF03666.13 EMC85394.1 - 7.3 5.3 11.3 13 4.4 11.3 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PDEase_I PF00233.19 EMC85395.1 - 3.6e-81 272.4 3.0 3.6e-81 272.4 3.0 2.6 3 0 0 3 3 3 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.26 EMC85395.1 - 3.9e-25 89.0 0.0 1.3e-12 48.5 0.0 2.3 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.6 EMC85395.1 - 4.1e-10 40.1 0.0 0.00031 21.1 0.0 2.4 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.6 EMC85395.1 - 1.2e-05 25.7 0.0 0.16 12.3 0.0 2.6 2 0 0 2 2 2 2 GAF domain SpoVT_C PF15714.5 EMC85395.1 - 0.043 13.9 4.3 0.46 10.5 0.0 3.3 4 0 0 4 4 4 0 Stage V sporulation protein T C-terminal, transcription factor FPL PF09758.9 EMC85395.1 - 0.057 13.4 1.5 0.2 11.6 1.0 2.2 2 0 0 2 2 2 0 Uncharacterised conserved protein Lipocalin PF00061.23 EMC85396.1 - 3.4e-23 82.4 0.0 5.2e-23 81.9 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_2 PF08212.12 EMC85396.1 - 1.3e-06 28.4 0.1 2.2e-06 27.6 0.1 1.4 1 1 0 1 1 1 1 Lipocalin-like domain Triabin PF03973.13 EMC85396.1 - 2e-05 24.5 0.4 6e-05 22.9 0.4 1.7 1 1 0 1 1 1 1 Triabin 7tm_1 PF00001.21 EMC85397.1 - 6.5e-38 130.6 23.7 7.6e-38 130.3 23.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) EABR PF12180.8 EMC85398.1 - 2.7e-17 62.1 1.7 2.7e-17 62.1 1.7 2.3 2 0 0 2 2 2 1 TSG101 and ALIX binding domain of CEP55 CC2-LZ PF16516.5 EMC85398.1 - 0.0015 18.8 17.0 0.0015 18.8 17.0 4.6 1 1 2 4 4 4 3 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator NusB PF01029.18 EMC85398.1 - 0.044 14.0 0.7 0.044 14.0 0.7 4.0 1 1 2 4 4 4 0 NusB family Fez1 PF06818.15 EMC85398.1 - 0.29 11.5 63.2 0.65 10.4 26.5 3.0 1 1 2 3 3 3 0 Fez1 ADIP PF11559.8 EMC85398.1 - 1.3 9.1 67.1 0.091 12.8 13.4 4.6 2 2 3 5 5 5 0 Afadin- and alpha -actinin-Binding C2 PF00168.30 EMC85399.1 - 3.3e-100 329.2 2.6 5.6e-19 68.3 0.0 8.5 7 1 1 8 8 8 8 C2 domain FerB PF08150.12 EMC85399.1 - 1.7e-31 108.6 0.1 4.4e-31 107.3 0.1 1.8 1 0 0 1 1 1 1 FerB (NUC096) domain Ferlin_C PF16165.5 EMC85399.1 - 1.1e-29 103.4 2.1 8e-26 90.8 0.1 2.5 1 1 1 2 2 2 2 Ferlin C-terminus FerA PF08165.11 EMC85399.1 - 1.5e-23 82.5 0.2 3.1e-23 81.5 0.2 1.6 1 0 0 1 1 1 1 FerA (NUC095) domain FerI PF08151.12 EMC85399.1 - 6.6e-19 67.7 0.1 1.6e-18 66.6 0.1 1.7 1 0 0 1 1 1 1 FerI (NUC094) domain PI3K_C2 PF00792.24 EMC85399.1 - 0.0058 16.5 0.1 2.4 8.1 0.0 2.9 2 0 0 2 2 2 2 Phosphoinositide 3-kinase C2 DUF812 PF05667.11 EMC85399.1 - 0.0098 14.8 0.5 0.015 14.2 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) SIP PF04954.13 EMC85399.1 - 0.086 13.4 0.2 0.22 12.0 0.2 1.7 1 0 0 1 1 1 0 Siderophore-interacting protein p450 PF00067.22 EMC85400.1 - 7.7e-60 202.9 0.0 5.2e-54 183.7 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 Homeodomain PF00046.29 EMC85401.1 - 1.7e-17 63.0 3.5 3.3e-17 62.1 3.5 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC85401.1 - 0.0069 16.3 0.1 0.017 15.0 0.1 1.7 1 0 0 1 1 1 1 Homeobox KN domain Terminase_5 PF06056.12 EMC85401.1 - 0.079 12.9 0.2 0.14 12.1 0.2 1.4 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) PTPRCAP PF15713.5 EMC85401.1 - 0.31 11.3 6.6 0.4 11.0 6.6 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Kinesin PF00225.23 EMC85402.1 - 6.2e-116 386.9 0.3 6.2e-116 386.9 0.3 3.3 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bind PF13931.6 EMC85402.1 - 8e-49 165.5 2.8 8e-49 165.5 2.8 4.8 3 2 2 5 5 5 1 Kinesin-associated microtubule-binding Microtub_bd PF16796.5 EMC85402.1 - 6e-23 81.4 0.1 6e-23 81.4 0.1 2.9 3 1 0 3 3 3 1 Microtubule binding SH3-WW_linker PF16618.5 EMC85402.1 - 0.023 15.2 3.9 0.11 13.0 3.9 2.3 1 0 0 1 1 1 0 Linker region between SH3 and WW domains on ARHGAP12 FAD-SLDH PF12318.8 EMC85402.1 - 5.3 7.1 9.4 0.27 11.3 0.1 3.5 4 1 0 4 4 4 0 Membrane bound FAD containing D-sorbitol dehydrogenase Peptidase_M16_M PF16187.5 EMC85403.1 - 3.6e-100 334.9 7.1 3.6e-100 334.9 7.1 1.7 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 EMC85403.1 - 3.8e-48 163.2 0.2 3.3e-46 157.0 0.1 2.7 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EMC85403.1 - 9.1e-40 136.6 0.1 8.1e-22 78.1 0.0 3.4 4 0 0 4 4 4 2 Peptidase M16 inactive domain Tn916-Xis PF09035.10 EMC85403.1 - 0.053 13.7 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Excisionase from transposon Tn916 RINGv PF12906.7 EMC85405.1 - 1.5e-14 53.9 10.9 2.2e-14 53.3 10.9 1.3 1 0 0 1 1 1 1 RING-variant domain DUF2517 PF10725.9 EMC85405.1 - 0.0011 18.7 0.1 0.003 17.3 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2517) zf-RING_2 PF13639.6 EMC85405.1 - 0.0024 18.2 6.6 0.0055 17.0 6.6 1.7 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 EMC85405.1 - 0.041 14.0 5.7 0.09 13.0 5.7 1.6 1 0 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 EMC85405.1 - 0.44 10.4 6.0 0.95 9.3 6.0 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-CSL PF05207.13 EMC85405.1 - 0.5 10.1 3.2 1.1 9.0 3.2 1.5 1 1 0 1 1 1 0 CSL zinc finger PHD PF00628.29 EMC85405.1 - 1.3 9.0 8.6 2.2 8.2 8.6 1.4 1 0 0 1 1 1 0 PHD-finger RRM_7 PF16367.5 EMC85406.1 - 8.4e-38 128.4 0.0 5.9e-36 122.5 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif CEBP_ZZ PF16366.5 EMC85406.1 - 1.6e-20 73.1 5.8 4.7e-20 71.6 5.8 1.9 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.22 EMC85406.1 - 9e-12 44.6 0.0 1.2e-06 28.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-U1 PF06220.12 EMC85406.1 - 0.034 13.9 0.6 0.082 12.7 0.6 1.6 1 0 0 1 1 1 0 U1 zinc finger zf-CGNR PF11706.8 EMC85406.1 - 0.068 13.0 0.4 0.068 13.0 0.4 2.0 2 0 0 2 2 2 0 CGNR zinc finger SKG6 PF08693.10 EMC85406.1 - 0.3 10.5 4.4 0.64 9.5 4.4 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain zf-B_box PF00643.24 EMC85406.1 - 0.32 11.2 5.8 0.83 9.9 5.8 1.7 1 0 0 1 1 1 0 B-box zinc finger DUF3535 PF12054.8 EMC85407.1 - 3.7e-135 451.6 8.6 2.1e-132 442.5 5.9 3.7 4 0 0 4 4 4 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 EMC85407.1 - 2.1e-59 201.0 0.0 9.6e-59 198.8 0.0 2.0 2 0 0 2 2 2 1 SNF2 family N-terminal domain HEAT PF02985.22 EMC85407.1 - 1.9e-20 71.2 22.3 0.0075 16.4 0.0 12.9 12 1 0 12 12 12 6 HEAT repeat Helicase_C PF00271.31 EMC85407.1 - 2.2e-17 63.4 0.0 6.8e-17 61.8 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT_2 PF13646.6 EMC85407.1 - 4e-11 43.2 2.0 0.035 14.5 0.4 6.5 6 1 1 7 7 7 4 HEAT repeats Vac14_Fab1_bd PF12755.7 EMC85407.1 - 9.8e-11 42.1 0.2 0.015 15.9 0.0 5.2 4 1 1 5 5 5 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EMC85407.1 - 3.3e-05 24.3 14.3 0.0041 17.6 0.1 7.7 8 0 0 8 8 8 1 HEAT-like repeat TAF6_C PF07571.13 EMC85407.1 - 6.6e-05 23.1 0.1 3 8.3 0.0 6.5 5 1 1 6 6 6 1 TAF6 C-terminal HEAT repeat domain Cnd1 PF12717.7 EMC85407.1 - 0.00068 19.7 6.4 0.3 11.1 0.2 4.9 4 1 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 UME PF08064.13 EMC85407.1 - 0.31 11.0 4.2 44 4.1 0.0 5.0 4 1 0 4 4 4 0 UME (NUC010) domain Arm PF00514.23 EMC85407.1 - 0.5 10.5 7.4 0.41 10.8 0.0 4.4 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat DSPc PF00782.20 EMC85408.1 - 5.1e-11 42.5 0.0 7.3e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC85408.1 - 0.016 14.8 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DSPn PF14671.6 EMC85408.1 - 0.077 13.4 0.0 0.13 12.7 0.0 1.4 1 1 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half Cyclin_C PF02984.19 EMC85409.1 - 8.5e-20 71.0 0.5 8.5e-20 71.0 0.5 3.1 3 0 0 3 3 3 2 Cyclin, C-terminal domain Cyclin_N PF00134.23 EMC85409.1 - 1.3e-19 70.2 1.5 2.2e-19 69.4 0.6 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain TFIIA PF03153.13 EMC85409.1 - 0.6 10.1 9.4 0.77 9.7 9.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit zf-C2H2 PF00096.26 EMC85410.1 - 7.7e-05 22.9 48.4 0.091 13.3 0.3 7.8 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 EMC85410.1 - 0.0078 16.0 0.3 0.0078 16.0 0.3 4.9 4 0 0 4 4 4 1 C2H2-type zinc-finger domain zf-ZPR1 PF03367.13 EMC85410.1 - 0.1 12.4 8.2 0.37 10.6 2.8 3.1 1 1 1 2 2 2 0 ZPR1 zinc-finger domain CLAMP PF14769.6 EMC85410.1 - 0.31 11.5 3.1 9.8 6.7 0.0 4.1 4 0 0 4 4 4 0 Flagellar C1a complex subunit C1a-32 zf-C2H2_4 PF13894.6 EMC85410.1 - 0.38 11.7 47.4 1.9 9.6 0.3 8.1 7 0 0 7 7 7 0 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 EMC85410.1 - 0.58 9.8 17.8 0.45 10.2 0.5 5.5 4 1 1 5 5 5 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-H2C2_2 PF13465.6 EMC85410.1 - 0.78 10.3 42.4 0.095 13.2 0.6 7.6 7 0 0 7 7 7 0 Zinc-finger double domain Blt1 PF12754.7 EMC85410.1 - 5.7 7.2 7.5 32 4.8 0.3 3.5 3 0 0 3 3 3 0 Blt1 N-terminal domain SH2 PF00017.24 EMC85411.1 - 2.7e-11 43.4 0.1 5.2e-11 42.5 0.1 1.5 1 0 0 1 1 1 1 SH2 domain DNA_pol_B_thumb PF14791.6 EMC85412.1 - 1.9e-20 72.8 0.3 5.9e-20 71.2 0.3 1.9 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 EMC85412.1 - 5.7e-18 64.5 0.1 1.3e-17 63.3 0.1 1.6 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 EMC85412.1 - 2.4e-13 50.2 0.0 1.2e-12 48.0 0.0 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix domain DNA_pol_B_palm PF14792.6 EMC85412.1 - 6.9e-09 35.9 0.0 1.5e-08 34.8 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta palm BRCT PF00533.26 EMC85412.1 - 6.9e-05 23.1 0.0 0.00023 21.5 0.0 2.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain NTP_transf_2 PF01909.23 EMC85412.1 - 0.00022 21.4 0.0 0.00056 20.1 0.0 1.8 1 0 0 1 1 1 1 Nucleotidyltransferase domain Cdd1 PF11731.8 EMC85412.1 - 0.0044 17.2 0.0 0.012 15.8 0.0 1.7 1 0 0 1 1 1 1 Pathogenicity locus BRCT_2 PF16589.5 EMC85412.1 - 0.096 13.1 0.0 0.21 12.0 0.0 1.5 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain Sulfotransfer_1 PF00685.27 EMC85413.1 - 6.6e-13 48.7 0.0 8.3e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC85413.1 - 0.0013 19.2 0.0 0.06 13.7 0.0 2.1 1 1 1 2 2 2 2 Sulfotransferase family Homeodomain PF00046.29 EMC85414.1 - 4.1e-20 71.4 5.2 5.5e-20 71.0 5.2 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC85414.1 - 0.00013 21.8 1.1 0.00025 20.9 0.4 1.8 2 0 0 2 2 2 1 Homeobox KN domain Phage_terminase PF10668.9 EMC85414.1 - 0.019 15.0 0.0 0.032 14.3 0.0 1.3 1 0 0 1 1 1 0 Phage terminase small subunit YdaS_antitoxin PF15943.5 EMC85414.1 - 0.16 11.8 0.7 0.31 10.9 0.0 1.7 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT RasGEF PF00617.19 EMC85415.1 - 2e-18 67.2 2.1 2e-18 67.2 2.1 2.3 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EMC85415.1 - 2.4e-13 50.2 0.5 1.3e-12 47.9 0.5 2.3 1 0 0 1 1 1 1 RasGEF N-terminal motif DUF2748 PF10871.8 EMC85415.1 - 0.086 11.5 1.9 0.16 10.6 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2748) TPR_6 PF13174.6 EMC85415.1 - 0.12 13.1 1.7 29 5.6 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat LRR_8 PF13855.6 EMC85416.1 - 4.2e-15 55.3 2.6 4.2e-15 55.3 2.6 2.3 2 1 0 2 2 2 1 Leucine rich repeat 7tm_2 PF00002.24 EMC85416.1 - 7.3e-13 48.4 7.2 1.3e-12 47.5 7.2 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 EMC85416.1 - 3.7e-08 33.8 0.1 3.7e-08 33.8 0.1 3.3 3 0 0 3 3 3 1 GPCR proteolysis site, GPS, motif LRR_4 PF12799.7 EMC85416.1 - 2.4e-07 30.9 9.8 5e-05 23.6 3.2 3.1 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) I-set PF07679.16 EMC85416.1 - 2.5e-07 30.7 0.0 4.9e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain HRM PF02793.22 EMC85416.1 - 6.7e-05 23.1 1.4 6.7e-05 23.1 1.4 2.4 3 0 0 3 3 3 1 Hormone receptor domain LRR_1 PF00560.33 EMC85416.1 - 0.00078 19.7 5.5 0.17 12.5 0.1 4.4 3 0 0 3 3 3 1 Leucine Rich Repeat LRR_5 PF13306.6 EMC85416.1 - 0.0033 17.4 1.1 0.016 15.2 0.1 2.6 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) ig PF00047.25 EMC85416.1 - 0.017 15.3 0.1 0.036 14.2 0.1 1.6 1 0 0 1 1 1 0 Immunoglobulin domain LRRCT PF01463.24 EMC85416.1 - 0.078 13.6 0.0 0.3 11.7 0.0 2.1 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain Neur_chan_LBD PF02931.23 EMC85418.1 - 1.5e-49 168.4 0.1 2e-49 168.0 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC85418.1 - 1.2e-25 91.0 4.6 1.7e-23 83.9 1.9 2.1 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region GDA1_CD39 PF01150.17 EMC85419.1 - 4e-137 457.3 0.3 4.9e-137 457.1 0.3 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family DDE_Tnp_IS1595 PF12762.7 EMC85419.1 - 0.046 13.7 0.1 0.081 12.9 0.1 1.3 1 0 0 1 1 1 0 ISXO2-like transposase domain SH3_9 PF14604.6 EMC85420.1 - 1.1e-53 178.8 4.0 3.8e-11 42.7 0.0 7.0 7 0 0 7 7 7 5 Variant SH3 domain SH3_1 PF00018.28 EMC85420.1 - 1.3e-51 172.0 0.3 4.9e-11 42.1 0.0 6.8 6 1 0 6 6 6 6 SH3 domain SH3_2 PF07653.17 EMC85420.1 - 7.5e-43 144.0 1.0 2e-06 27.4 0.0 6.5 6 0 0 6 6 6 6 Variant SH3 domain BAR PF03114.18 EMC85420.1 - 1.6e-41 142.5 3.8 1.6e-41 142.5 3.8 1.9 2 0 0 2 2 2 1 BAR domain RhoGEF PF00621.20 EMC85420.1 - 3.2e-37 128.5 0.7 3.2e-37 128.5 0.7 2.0 2 1 1 3 3 3 1 RhoGEF domain CNTF PF01110.17 EMC85420.1 - 0.00018 20.9 1.8 0.00018 20.9 1.8 2.4 2 0 0 2 2 2 1 Ciliary neurotrophic factor HR1 PF02185.16 EMC85420.1 - 3.3 7.9 9.0 0.23 11.6 1.6 2.9 3 0 0 3 3 3 0 Hr1 repeat ABC_membrane PF00664.23 EMC85421.1 - 2.8e-77 260.1 33.0 6.8e-40 137.4 11.7 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EMC85421.1 - 1.5e-53 181.0 1.8 3.5e-29 102.1 0.0 3.0 3 0 0 3 3 3 2 ABC transporter SMC_N PF02463.19 EMC85421.1 - 2.1e-09 37.1 3.5 0.0095 15.4 0.0 4.4 2 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EMC85421.1 - 9.5e-07 28.9 2.0 0.011 15.8 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EMC85421.1 - 4.8e-06 27.1 0.2 0.14 12.5 0.1 2.7 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EMC85421.1 - 2e-05 24.5 0.2 0.33 10.8 0.1 2.7 2 1 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EMC85421.1 - 0.00018 21.2 0.8 0.16 11.7 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EMC85421.1 - 0.0041 17.4 0.5 6.5 7.0 0.2 3.4 2 1 0 2 2 2 1 AAA domain DUF87 PF01935.17 EMC85421.1 - 0.0045 17.1 11.0 0.1 12.6 0.1 3.5 3 0 0 3 3 3 2 Helicase HerA, central domain Zeta_toxin PF06414.12 EMC85421.1 - 0.0058 15.9 0.5 2.3 7.5 0.1 2.5 2 0 0 2 2 2 2 Zeta toxin T2SSE PF00437.20 EMC85421.1 - 0.0059 15.7 0.1 2.9 6.9 0.0 2.6 2 0 0 2 2 2 2 Type II/IV secretion system protein DUF815 PF05673.13 EMC85421.1 - 0.0068 15.6 0.2 1.2 8.2 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Dynamin_N PF00350.23 EMC85421.1 - 0.017 15.2 8.7 0.11 12.5 0.7 3.1 3 0 0 3 3 3 0 Dynamin family MeaB PF03308.16 EMC85421.1 - 0.027 13.5 0.0 1.4 7.8 0.0 2.6 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP_bind_1 PF03029.17 EMC85421.1 - 0.032 14.0 0.7 2.1 8.1 0.1 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_7 PF12775.7 EMC85421.1 - 0.056 12.9 2.0 7.6 6.0 0.0 2.8 3 0 0 3 3 3 0 P-loop containing dynein motor region FtsK_SpoIIIE PF01580.18 EMC85421.1 - 0.057 12.8 0.5 2 7.7 0.0 2.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_24 PF13479.6 EMC85421.1 - 0.091 12.5 0.4 1.9 8.2 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 EMC85421.1 - 0.12 12.1 0.7 17 5.1 0.0 3.2 3 0 0 3 3 3 0 AAA domain AAA_23 PF13476.6 EMC85421.1 - 0.14 12.6 10.8 8.1 6.9 0.1 4.2 4 0 0 4 4 4 0 AAA domain AAA_21 PF13304.6 EMC85421.1 - 0.2 11.4 2.5 11 5.7 0.1 3.4 3 1 1 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system TrwB_AAD_bind PF10412.9 EMC85421.1 - 0.22 10.4 2.7 7.4 5.4 0.0 2.7 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain CutC PF03932.14 EMC85422.1 - 1.9e-57 194.0 0.0 3.9e-57 193.0 0.0 1.4 2 0 0 2 2 2 1 CutC family TMP-TENI PF02581.17 EMC85422.1 - 0.094 12.0 0.1 0.16 11.2 0.1 1.6 1 1 0 1 1 1 0 Thiamine monophosphate synthase COX15-CtaA PF02628.15 EMC85423.1 - 3.2e-104 348.5 3.5 3.7e-104 348.3 3.5 1.0 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein DUF4807 PF16065.5 EMC85423.1 - 0.051 13.2 0.1 0.12 12.1 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4807) ATP_synt_H PF05493.13 EMC85424.1 - 5.5e-20 71.6 4.1 7.2e-20 71.2 4.1 1.2 1 0 0 1 1 1 1 ATP synthase subunit H VEGFR-2_TMD PF17988.1 EMC85424.1 - 0.03 13.7 1.9 0.067 12.6 1.9 1.6 1 0 0 1 1 1 0 VEGFR-2 Transmembrane domain GDA1_CD39 PF01150.17 EMC85425.1 - 2.3e-90 303.3 0.0 3e-90 302.9 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Mito_carr PF00153.27 EMC85426.1 - 7e-50 166.9 1.0 2.9e-20 72.0 0.6 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein SAT PF16073.5 EMC85426.1 - 0.014 15.1 0.1 0.018 14.8 0.1 1.3 1 0 0 1 1 1 0 Starter unit:ACP transacylase in aflatoxin biosynthesis NDUF_B6 PF09782.9 EMC85426.1 - 0.046 13.8 0.9 0.13 12.4 0.0 2.1 2 0 0 2 2 2 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit Serine_protease PF18405.1 EMC85426.1 - 0.068 12.3 2.7 3.7 6.6 1.3 2.3 1 1 1 2 2 2 0 Gammaproteobacterial serine protease Aminotran_1_2 PF00155.21 EMC85428.1 - 2.3e-83 280.4 0.0 2.7e-83 280.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II CBS PF00571.28 EMC85429.1 - 2.8e-07 30.9 0.6 0.00011 22.5 0.0 2.5 2 0 0 2 2 2 2 CBS domain cNMP_binding PF00027.29 EMC85429.1 - 0.04 14.0 0.0 0.12 12.5 0.0 1.8 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain UPF0231 PF06062.11 EMC85430.1 - 0.11 12.8 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0231) GDI PF00996.18 EMC85431.1 - 0.0044 15.6 0.0 0.0062 15.1 0.0 1.1 1 0 0 1 1 1 1 GDP dissociation inhibitor DAO PF01266.24 EMC85431.1 - 0.058 13.0 0.5 0.12 11.9 0.1 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase SRCR PF00530.18 EMC85432.1 - 2.7e-100 329.5 30.0 2.5e-29 101.7 5.6 4.1 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 EMC85432.1 - 1.5e-21 76.7 14.3 8.2e-05 23.1 0.1 4.3 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 EMC85432.1 - 2.3e-11 44.2 2.7 0.062 13.8 0.0 4.3 4 0 0 4 4 4 4 Hepsin, SRCR domain YecR PF13992.6 EMC85432.1 - 0.16 12.3 5.5 6.8 7.1 0.1 3.7 4 0 0 4 4 4 0 YecR-like lipoprotein Lysyl_oxidase PF01186.17 EMC85433.1 - 2.5e-64 216.7 3.5 3e-64 216.5 3.5 1.0 1 0 0 1 1 1 1 Lysyl oxidase CARDB PF07705.11 EMC85433.1 - 0.0014 18.9 0.0 0.0032 17.7 0.0 1.5 2 0 0 2 2 2 1 CARDB DNA_ligase_A_M PF01068.21 EMC85433.1 - 0.034 13.8 0.0 0.12 12.0 0.0 1.8 2 0 0 2 2 2 0 ATP dependent DNA ligase domain Cathelicidins PF00666.17 EMC85433.1 - 0.077 13.3 0.4 0.12 12.7 0.0 1.5 2 0 0 2 2 2 0 Cathelicidin Y_Y_Y PF07495.13 EMC85433.1 - 0.079 12.9 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Y_Y_Y domain PRIMA1 PF16101.5 EMC85434.1 - 0.46 10.5 4.1 0.1 12.6 0.9 1.6 1 1 0 1 1 1 0 Proline-rich membrane anchor 1 NCBP3 PF10309.9 EMC85435.1 - 4.4e-05 23.3 0.0 7.4e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 RNA_bind PF08675.11 EMC85435.1 - 0.0043 17.1 0.0 0.0075 16.3 0.0 1.3 1 0 0 1 1 1 1 RNA binding domain VCBS PF13517.6 EMC85436.1 - 8.1e-31 106.4 14.0 1.7e-11 44.5 1.6 5.1 4 1 1 5 5 5 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella UnbV_ASPIC PF07593.12 EMC85436.1 - 3.8e-14 52.4 0.0 7.9e-14 51.4 0.0 1.5 1 0 0 1 1 1 1 ASPIC and UnbV FG-GAP PF01839.23 EMC85436.1 - 6.4e-13 48.6 16.4 0.0013 18.8 0.0 5.3 5 0 0 5 5 5 4 FG-GAP repeat EGF_CA PF07645.15 EMC85436.1 - 1.9e-10 40.8 7.8 1.9e-10 40.8 7.8 1.8 2 0 0 2 2 2 1 Calcium-binding EGF domain cEGF PF12662.7 EMC85436.1 - 0.042 13.8 9.9 0.81 9.7 2.3 2.8 2 0 0 2 2 2 0 Complement Clr-like EGF-like Imm75 PF15660.6 EMC85436.1 - 0.17 12.2 0.3 0.46 10.8 0.1 1.9 2 0 0 2 2 2 0 Putative Immunity protein 75 Erf4 PF10256.9 EMC85437.1 - 9.5e-33 112.8 0.0 1.1e-32 112.5 0.0 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family NTR PF01759.21 EMC85438.1 - 2.4e-15 56.2 0.1 3.1e-15 55.9 0.1 1.2 1 0 0 1 1 1 1 UNC-6/NTR/C345C module TIMP PF00965.17 EMC85438.1 - 0.011 15.5 0.1 0.017 15.0 0.1 1.3 1 0 0 1 1 1 0 Tissue inhibitor of metalloproteinase PI3_PI4_kinase PF00454.27 EMC85439.1 - 5e-63 213.2 0.0 6e-63 213.0 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase MORN PF02493.20 EMC85440.1 - 2.1e-26 90.2 21.6 3.4e-08 32.9 0.3 5.7 6 0 0 6 6 6 4 MORN repeat HCBP_related PF06594.11 EMC85440.1 - 0.021 14.8 2.4 0.2 11.6 0.1 2.9 3 0 0 3 3 3 0 Haemolysin-type calcium binding protein related domain DHDPS PF00701.22 EMC85441.1 - 1.1e-52 178.6 0.0 1.3e-52 178.4 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Ank_4 PF13637.6 EMC85442.1 - 1.4e-05 25.6 0.0 2.1e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC85442.1 - 2.8e-05 24.6 0.0 4.1e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EMC85442.1 - 0.00034 20.9 0.0 0.0027 18.1 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 EMC85442.1 - 0.00079 19.7 0.0 0.012 16.1 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 EMC85442.1 - 0.043 14.1 0.0 0.076 13.4 0.0 1.4 1 0 0 1 1 1 0 Ankyrin repeats (many copies) UBD PF16455.5 EMC85443.1 - 4.1e-37 126.6 0.0 7.2e-37 125.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-binding domain ubiquitin PF00240.23 EMC85443.1 - 3.5e-16 58.7 0.2 6.1e-16 57.9 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EMC85443.1 - 7.2e-06 25.7 0.0 1.1e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like MMS19_C PF12460.8 EMC85444.1 - 3.8e-94 316.2 20.7 3.3e-55 187.9 0.3 4.4 2 2 1 3 3 3 3 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 EMC85444.1 - 4.4e-90 301.8 0.3 4.4e-90 301.8 0.3 3.8 4 1 1 5 5 5 2 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_2 PF13646.6 EMC85444.1 - 0.00034 20.9 10.9 0.053 13.9 0.7 6.1 4 2 3 7 7 7 2 HEAT repeats MIF4G PF02854.19 EMC85444.1 - 0.015 14.9 0.0 0.065 12.9 0.0 2.0 2 0 0 2 2 2 0 MIF4G domain RhoGAP PF00620.27 EMC85444.1 - 0.034 14.0 1.4 0.28 11.0 0.0 3.0 3 0 0 3 3 3 0 RhoGAP domain HEAT_EZ PF13513.6 EMC85444.1 - 0.29 11.7 17.7 4.4 7.9 0.1 7.3 6 1 1 7 7 7 0 HEAT-like repeat His_Phos_1 PF00300.22 EMC85445.1 - 1.2e-06 28.4 0.0 1.4e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) RhoGAP PF00620.27 EMC85446.1 - 8.8e-36 123.0 0.4 8.8e-36 123.0 0.4 1.7 2 0 0 2 2 2 1 RhoGAP domain HTH_psq PF05225.16 EMC85448.1 - 1.4e-14 53.5 0.1 3.6e-14 52.2 0.0 1.8 2 0 0 2 2 2 1 helix-turn-helix, Psq domain LIM_bind PF01803.16 EMC85449.1 - 2.4e-23 82.9 9.2 4.4e-12 46.0 0.1 2.7 2 1 1 3 3 3 2 LIM-domain binding protein Prominin PF05478.11 EMC85450.1 - 1.7e-120 403.4 2.2 1.9e-120 403.2 2.2 1.0 1 0 0 1 1 1 1 Prominin Flagellar_rod PF05149.12 EMC85450.1 - 0.039 13.4 0.1 0.066 12.7 0.1 1.3 1 0 0 1 1 1 0 Paraflagellar rod protein COG2 PF06148.11 EMC85450.1 - 0.049 13.7 0.6 0.22 11.6 0.6 2.0 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1451 PF07295.11 EMC85450.1 - 0.12 12.4 3.0 0.86 9.6 1.6 2.2 1 1 1 2 2 2 0 Zinc-ribbon containing domain GrpE PF01025.19 EMC85450.1 - 0.15 11.7 3.6 0.29 10.8 3.0 1.7 1 1 1 2 2 2 0 GrpE Sec34 PF04136.15 EMC85450.1 - 0.39 10.6 3.5 1.5 8.7 1.0 2.3 2 0 0 2 2 2 0 Sec34-like family BAR PF03114.18 EMC85450.1 - 0.65 9.6 5.1 3.2 7.3 4.5 2.4 2 1 0 2 2 2 0 BAR domain Nup54_57_C PF18570.1 EMC85450.1 - 0.91 9.2 3.2 0.62 9.7 1.1 1.9 2 0 0 2 2 2 0 NUP57/Nup54 C-terminal domain Baculo_PEP_C PF04513.12 EMC85450.1 - 2.1 8.4 6.6 1.3 9.0 2.9 2.4 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1741 PF08427.10 EMC85451.1 - 3e-84 282.3 6.1 5.7e-84 281.4 6.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) EF-hand_7 PF13499.6 EMC85452.1 - 9.8e-24 83.6 5.6 2.3e-16 60.0 0.5 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EMC85452.1 - 7.9e-22 75.1 9.4 1.9e-07 30.1 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EMC85452.1 - 1.7e-18 64.9 7.7 8.5e-06 25.3 0.1 4.3 4 1 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 EMC85452.1 - 1.6e-17 62.2 3.7 1.4e-05 24.4 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EMC85452.1 - 3.6e-15 55.5 4.1 1e-06 28.5 0.1 3.3 3 1 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EMC85452.1 - 6.6e-06 26.4 3.1 0.0018 18.6 0.7 3.3 2 2 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EMC85452.1 - 0.00025 21.0 2.1 0.047 13.6 0.1 2.9 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EMC85452.1 - 0.0064 16.8 0.2 0.44 10.9 0.1 2.8 2 1 0 2 2 2 1 EF-hand domain UPF0223 PF05256.12 EMC85452.1 - 0.0065 16.8 1.1 0.97 9.8 0.1 2.5 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0223) Dockerin_1 PF00404.18 EMC85452.1 - 0.038 14.2 1.0 2.9 8.2 0.3 2.8 1 1 1 2 2 2 0 Dockerin type I domain Caleosin PF05042.13 EMC85452.1 - 0.11 12.4 5.8 4.5 7.2 0.2 3.5 1 1 2 3 3 3 0 Caleosin related protein NAGidase PF07555.13 EMC85454.1 - 2.8e-76 256.7 0.0 4.7e-76 255.9 0.0 1.3 1 0 0 1 1 1 1 beta-N-acetylglucosaminidase Nucleoplasmin PF03066.15 EMC85455.1 - 1.3e-34 118.7 0.0 1.6e-34 118.4 0.0 1.1 1 0 0 1 1 1 1 Nucleoplasmin/nucleophosmin domain Nitrophorin PF02087.15 EMC85455.1 - 0.0018 18.3 0.1 0.0024 17.9 0.1 1.2 1 0 0 1 1 1 1 Nitrophorin FGF PF00167.18 EMC85456.1 - 1.3e-42 144.9 1.0 1.9e-42 144.3 1.0 1.3 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.13 EMC85456.1 - 0.075 13.3 0.0 0.15 12.3 0.0 1.5 1 1 0 1 1 1 0 Fascin domain DPCD PF14913.6 EMC85457.1 - 2.8e-84 281.2 0.8 3.1e-84 281.1 0.8 1.0 1 0 0 1 1 1 1 DPCD protein family Mcl1_mid PF12341.8 EMC85457.1 - 0.018 14.4 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 Minichromosome loss protein, Mcl1, middle region DUF2914 PF11141.8 EMC85457.1 - 0.074 12.8 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2914) Sugar_tr PF00083.24 EMC85460.1 - 2.7e-103 346.2 23.3 3.1e-103 346.1 23.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMC85460.1 - 9.6e-17 60.9 57.2 5.4e-16 58.5 29.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily WD40 PF00400.32 EMC85461.1 - 1e-39 133.8 18.6 2.3e-06 28.2 0.2 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat Beta-TrCP_D PF12125.8 EMC85461.1 - 3.7e-24 84.3 4.0 7.4e-24 83.4 4.0 1.5 1 0 0 1 1 1 1 D domain of beta-TrCP F-box-like PF12937.7 EMC85461.1 - 1.7e-10 40.6 0.5 5.1e-10 39.1 0.2 2.0 1 1 1 2 2 2 1 F-box-like ANAPC4_WD40 PF12894.7 EMC85461.1 - 2.7e-09 37.2 2.1 0.06 13.7 0.0 4.4 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 EMC85461.1 - 6.7e-07 29.0 0.0 1.8e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 F-box domain WD40_like PF17005.5 EMC85461.1 - 5.6e-06 25.9 0.3 0.0038 16.6 0.1 2.4 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 EMC85461.1 - 6.8e-05 21.7 6.8 0.096 11.3 0.1 4.5 3 1 2 5 5 5 2 Nucleoporin Nup120/160 F-box_5 PF18511.1 EMC85461.1 - 0.0062 16.1 0.1 0.019 14.5 0.1 1.9 1 0 0 1 1 1 1 F-box eIF2A PF08662.11 EMC85461.1 - 0.039 13.8 0.0 4.4 7.1 0.0 2.5 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A DUF4508 PF14969.6 EMC85461.1 - 0.059 13.6 0.1 0.12 12.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) DUF5046 PF16465.5 EMC85461.1 - 0.073 12.5 0.2 5.6 6.3 0.1 3.1 1 1 3 4 4 4 0 Domain of unknown function (DUF5046) 120_Rick_ant PF12574.8 EMC85461.1 - 0.12 11.5 0.1 0.59 9.3 0.0 1.9 1 1 1 2 2 2 0 120 KDa Rickettsia surface antigen Ig_3 PF13927.6 EMC85462.1 - 1.5e-14 54.4 0.0 2.4e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC85462.1 - 3.6e-14 52.6 0.0 5.2e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain IGFBP PF00219.18 EMC85462.1 - 1.3e-08 35.4 20.2 1.3e-08 35.4 20.2 2.0 2 0 0 2 2 2 1 Insulin-like growth factor binding protein ig PF00047.25 EMC85462.1 - 4.5e-07 29.9 0.0 2.3e-06 27.7 0.0 2.1 1 1 1 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 EMC85462.1 - 2.3e-06 27.9 0.0 5.5e-06 26.6 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain Kazal_2 PF07648.15 EMC85462.1 - 8.1e-05 22.7 11.3 0.00011 22.2 0.6 2.7 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EMC85462.1 - 0.00012 22.0 0.3 0.00012 22.0 0.3 2.1 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain V-set PF07686.17 EMC85462.1 - 0.0024 18.0 0.0 0.0061 16.7 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin V-set domain Mtc PF03820.17 EMC85463.1 - 5.1e-149 495.5 0.0 5.8e-149 495.3 0.0 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier PDZ PF00595.24 EMC85464.1 - 7e-36 122.4 1.2 3e-17 62.7 0.3 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 EMC85464.1 - 4.1e-22 77.8 0.4 7.1e-11 41.8 0.0 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 EMC85464.1 - 5.5e-13 49.0 0.2 3.7e-05 24.0 0.0 2.5 2 0 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 EMC85464.1 - 0.0072 16.3 1.1 1.6 8.7 0.0 2.7 3 0 0 3 3 3 2 Tricorn protease PDZ domain AAA_25 PF13481.6 EMC85466.1 - 5.2e-20 71.8 0.0 9.8e-20 70.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 EMC85466.1 - 6.5e-08 32.2 0.0 9.6e-08 31.7 0.0 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain ATPase PF06745.13 EMC85466.1 - 3.5e-07 29.8 0.0 5.7e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 KaiC AAA_16 PF13191.6 EMC85466.1 - 2.6e-06 27.9 0.0 8.9e-06 26.2 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EMC85466.1 - 8.3e-06 26.1 0.0 2e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EMC85466.1 - 0.00017 20.8 0.0 0.00024 20.2 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_29 PF13555.6 EMC85466.1 - 0.00064 19.4 0.0 0.0016 18.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 EMC85466.1 - 0.00096 19.7 0.0 0.0019 18.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EMC85466.1 - 0.014 15.8 0.0 0.027 14.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EMC85466.1 - 0.024 14.8 0.0 0.081 13.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 EMC85466.1 - 0.084 12.3 0.1 0.18 11.2 0.0 1.5 2 0 0 2 2 2 0 PhoH-like protein AAA_7 PF12775.7 EMC85466.1 - 0.1 12.1 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region cobW PF02492.19 EMC85466.1 - 0.14 11.7 0.1 0.25 10.9 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 EMC85466.1 - 0.15 12.6 0.1 0.28 11.7 0.1 1.4 1 0 0 1 1 1 0 ABC transporter TsaE PF02367.17 EMC85466.1 - 0.15 12.0 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE L51_S25_CI-B8 PF05047.16 EMC85467.1 - 7.2e-08 32.2 0.0 1.9e-07 30.9 0.0 1.6 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Sema PF01403.19 EMC85468.1 - 2.8e-148 494.3 0.0 3.6e-148 493.9 0.0 1.1 1 0 0 1 1 1 1 Sema domain PSI PF01437.25 EMC85468.1 - 7.6e-05 23.2 4.4 0.00028 21.4 4.4 2.0 1 0 0 1 1 1 1 Plexin repeat ig PF00047.25 EMC85468.1 - 0.012 15.8 0.0 0.035 14.3 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain Ig_3 PF13927.6 EMC85468.1 - 0.018 15.7 0.0 0.065 13.8 0.0 2.0 1 0 0 1 1 1 0 Immunoglobulin domain OSTbeta PF15048.6 EMC85468.1 - 0.16 12.1 0.0 0.3 11.2 0.0 1.4 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein PSI_integrin PF17205.3 EMC85468.1 - 0.73 9.6 2.8 2 8.2 2.8 1.8 1 0 0 1 1 1 0 Integrin plexin domain FAM178 PF14816.6 EMC85469.1 - 1.9e-148 494.4 4.8 2.4e-148 494.1 4.8 1.1 1 0 0 1 1 1 1 Family of unknown function, FAM178 TMEM52 PF14979.6 EMC85470.1 - 0.28 11.1 2.8 0.16 11.9 0.6 1.7 2 1 0 2 2 2 0 Transmembrane 52 CNDH2_M PF16869.5 EMC85470.1 - 1.2 9.9 6.3 1 10.0 4.6 1.8 1 1 1 2 2 2 0 PF16858 Sox_N PF12444.8 EMC85471.1 - 7e-10 39.9 11.7 1e+02 4.1 0.0 11.2 3 2 9 12 12 12 0 Sox developmental protein N terminal DDDD PF10161.9 EMC85471.1 - 0.053 13.3 0.4 1.9e+02 1.9 0.0 4.3 1 1 4 5 5 5 0 Putative mitochondrial precursor protein DUF645 PF04875.12 EMC85471.1 - 7.8 6.6 25.8 25 5.0 0.2 6.0 2 2 3 5 5 5 0 Protein of unknown function, DUF645 Dynamin_M PF01031.20 EMC85472.1 - 5.7e-80 268.6 2.1 3.6e-79 265.9 0.3 2.8 2 1 1 3 3 3 1 Dynamin central region Dynamin_N PF00350.23 EMC85472.1 - 9.3e-42 142.9 0.0 2.6e-41 141.5 0.0 1.8 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 EMC85472.1 - 5.1e-27 93.9 3.4 1.3e-26 92.5 3.4 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain PH PF00169.29 EMC85472.1 - 6e-09 36.4 0.2 1.4e-08 35.2 0.2 1.6 1 0 0 1 1 1 1 PH domain RPA PF10134.9 EMC85472.1 - 0.056 12.9 0.2 0.18 11.3 0.0 1.9 3 0 0 3 3 3 0 Replication initiator protein A PH_11 PF15413.6 EMC85472.1 - 0.11 12.9 0.5 0.54 10.7 0.1 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain Vinculin PF01044.19 EMC85475.1 - 1.3e-22 80.0 1.6 1.5e-22 79.8 1.6 1.0 1 0 0 1 1 1 1 Vinculin family Laminin_EGF PF00053.24 EMC85476.1 - 1.5e-40 137.1 99.8 9.7e-10 38.4 16.5 5.3 4 1 1 5 5 5 5 Laminin EGF domain TMEM154 PF15102.6 EMC85476.1 - 0.0037 17.2 0.3 0.006 16.5 0.3 1.2 1 0 0 1 1 1 1 TMEM154 protein family DUF3262 PF11660.8 EMC85476.1 - 0.062 13.7 0.6 0.13 12.6 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3262) Stevor PF17410.2 EMC85476.1 - 0.072 12.6 0.2 0.12 11.9 0.2 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Cnn_1N PF07989.11 EMC85477.1 - 2.9e-24 85.0 7.7 2.9e-24 85.0 7.7 10.9 8 3 2 10 10 10 2 Centrosomin N-terminal motif 1 PKHD_C PF18331.1 EMC85477.1 - 0.091 12.8 1.9 0.53 10.4 0.0 3.5 4 0 0 4 4 4 0 PKHD-type hydroxylase C-terminal domain MutS_IV PF05190.18 EMC85478.1 - 0.057 13.8 1.4 3.8 7.9 0.0 2.3 2 0 0 2 2 2 0 MutS family domain IV TMF_DNA_bd PF12329.8 EMC85478.1 - 1.8 8.6 11.5 0.11 12.5 4.5 2.2 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding MACPF PF01823.19 EMC85479.1 - 3.7e-07 30.4 0.1 1.4e-06 28.6 0.0 2.0 2 0 0 2 2 2 1 MAC/Perforin domain RhoGAP-FF1 PF16512.5 EMC85479.1 - 0.094 13.4 0.1 0.81 10.4 0.1 2.4 2 0 0 2 2 2 0 p190-A and -B Rho GAPs FF domain HTH_36 PF13730.6 EMC85479.1 - 0.11 12.4 0.0 0.38 10.7 0.0 2.0 1 0 0 1 1 1 0 Helix-turn-helix domain LRR_8 PF13855.6 EMC85480.1 - 3.6e-47 158.0 51.4 1.8e-13 50.0 1.5 9.4 4 3 3 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 EMC85480.1 - 5.4e-23 80.7 47.8 2.3e-05 24.7 1.7 9.6 5 2 3 10 10 10 6 Leucine Rich repeats (2 copies) TIR PF01582.20 EMC85480.1 - 6e-21 75.0 0.1 9.8e-21 74.3 0.1 1.3 1 0 0 1 1 1 1 TIR domain LRR_5 PF13306.6 EMC85480.1 - 8.2e-13 48.4 14.8 3.8e-07 30.1 0.1 5.0 3 1 2 5 5 5 4 BspA type Leucine rich repeat region (6 copies) TIR_2 PF13676.6 EMC85480.1 - 6.1e-11 43.0 0.1 2.1e-10 41.2 0.0 1.9 2 0 0 2 2 2 1 TIR domain LRR_1 PF00560.33 EMC85480.1 - 2.3e-09 36.5 38.6 0.73 10.6 0.3 12.7 13 1 0 13 13 13 5 Leucine Rich Repeat LRR_9 PF14580.6 EMC85480.1 - 1.8e-06 27.6 15.7 0.006 16.1 0.6 4.6 3 2 2 5 5 5 2 Leucine-rich repeat LRR_6 PF13516.6 EMC85480.1 - 0.0082 16.1 47.4 0.55 10.4 0.2 11.6 13 0 0 13 13 13 3 Leucine Rich repeat Annexin_like PF18411.1 EMC85481.1 - 9.8e-56 186.0 0.1 2.6e-55 184.7 0.1 1.8 1 0 0 1 1 1 1 Annexin-like domain ASTN_2_hairpin PF18577.1 EMC85481.1 - 4.2e-28 97.2 0.7 1e-27 95.9 0.7 1.7 1 0 0 1 1 1 1 Astrotactin-2 C-terminal beta-hairpin domain FXa_inhibition PF14670.6 EMC85481.1 - 9e-11 41.9 4.0 9e-11 41.9 4.0 4.3 4 0 0 4 4 4 2 Coagulation Factor Xa inhibitory site MACPF PF01823.19 EMC85481.1 - 2.4e-07 31.1 0.5 1.6e-06 28.4 0.2 2.1 2 0 0 2 2 2 1 MAC/Perforin domain cEGF PF12662.7 EMC85481.1 - 0.0015 18.4 5.1 0.11 12.4 0.4 3.5 2 0 0 2 2 2 2 Complement Clr-like EGF-like fn3 PF00041.21 EMC85481.1 - 0.025 14.9 0.0 0.1 12.9 0.0 1.9 1 1 0 1 1 1 0 Fibronectin type III domain Sushi PF00084.20 EMC85482.1 - 3.9e-22 78.6 46.6 8.8e-08 32.6 3.6 9.6 8 1 1 9 9 9 4 Sushi repeat (SCR repeat) Laminin_G_3 PF13385.6 EMC85482.1 - 6.8e-22 78.3 0.1 1.3e-21 77.3 0.1 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Peptidase_M43 PF05572.13 EMC85482.1 - 2.1e-08 34.2 0.7 7.1e-08 32.5 0.1 2.3 1 1 0 1 1 1 1 Pregnancy-associated plasma protein-A Notch PF00066.17 EMC85482.1 - 8e-06 26.2 58.3 0.00039 20.8 5.0 6.4 5 0 0 5 5 5 3 LNR domain DUF4215 PF13948.6 EMC85482.1 - 0.00024 21.5 6.4 0.00024 21.5 6.4 7.9 9 0 0 9 9 9 1 Domain of unknown function (DUF4215) Reprolysin_3 PF13582.6 EMC85482.1 - 0.0048 17.4 0.2 0.013 16.0 0.2 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EMC85482.1 - 0.11 12.1 0.1 0.34 10.5 0.1 1.7 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 EMC85482.1 - 0.63 9.9 1.9 1.7 8.5 1.9 1.6 1 0 0 1 1 1 0 Matrixin fn3 PF00041.21 EMC85483.1 - 1.3e-208 676.0 33.7 1.2e-15 57.6 0.0 15.3 15 0 0 15 15 15 15 Fibronectin type III domain Fibrinogen_C PF00147.18 EMC85483.1 - 3.3e-86 288.7 7.0 5.4e-86 287.9 7.0 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_2 PF07974.13 EMC85483.1 - 8.4e-56 186.0 255.2 7.3e-05 23.1 11.2 13.5 13 0 0 13 13 13 13 EGF-like domain EGF_Tenascin PF18720.1 EMC85483.1 - 5.2e-50 166.8 220.3 1.3e-06 28.3 11.9 13.4 13 0 0 13 13 13 12 Tenascin EGF domain EGF PF00008.27 EMC85483.1 - 1.4e-23 82.8 223.4 0.00022 21.5 9.3 13.5 13 0 0 13 13 13 12 EGF-like domain Pur_ac_phosph_N PF16656.5 EMC85483.1 - 9.3e-21 74.2 29.5 0.0018 18.8 0.6 14.6 13 4 0 13 13 13 6 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 EMC85483.1 - 6.2e-14 52.2 0.0 0.39 11.1 0.0 8.8 11 1 1 12 12 9 3 Interferon-alpha/beta receptor, fibronectin type III hEGF PF12661.7 EMC85483.1 - 2.3e-13 50.2 175.6 0.035 14.7 7.7 13.7 13 0 0 13 13 13 10 Human growth factor-like EGF DUF2369 PF10179.9 EMC85483.1 - 3.5e-12 46.5 7.6 0.16 12.4 0.0 10.6 11 1 0 11 11 11 1 Uncharacterised conserved protein (DUF2369) fn3_2 PF16893.5 EMC85483.1 - 3.5e-08 33.5 5.4 1.1 9.5 0.0 10.1 12 0 0 12 12 12 1 Fibronectin type III domain DUF4998 PF16389.5 EMC85483.1 - 1e-07 31.8 0.1 2.2 7.8 0.0 6.6 6 2 1 7 7 7 2 Domain of unknown function DUF4959 PF16323.5 EMC85483.1 - 1.4e-05 25.4 1.3 16 5.8 0.0 7.1 7 1 1 8 8 8 0 Domain of unknown function (DUF4959) Big_5 PF13205.6 EMC85483.1 - 0.0056 17.4 20.9 0.49 11.1 0.4 7.7 8 1 0 9 9 7 1 Bacterial Ig-like domain DUF4945 PF16303.5 EMC85483.1 - 0.027 14.4 2.7 67 3.5 0.1 6.1 7 0 0 7 7 6 0 Domain of unknown function (DUF4945) PA14 PF07691.12 EMC85483.1 - 0.13 12.1 0.9 9.1 6.1 0.1 3.7 4 0 0 4 4 3 0 PA14 domain Actin PF00022.19 EMC85483.1 - 0.23 10.0 3.5 61 2.0 0.1 5.1 4 2 1 5 5 5 0 Actin Big_10 PF17964.1 EMC85483.1 - 9.2 6.2 7.7 18 5.2 0.3 4.2 4 0 0 4 4 4 0 Bacterial Ig domain TNF PF00229.18 EMC85484.1 - 4.4e-13 49.3 0.0 8.7e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family TusA PF01206.17 EMC85484.1 - 0.056 13.3 0.1 1.4 8.8 0.0 2.4 1 1 1 2 2 2 0 Sulfurtransferase TusA TNF PF00229.18 EMC85485.1 - 1.3e-36 125.4 0.1 1.9e-36 124.8 0.1 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family DUF4457 PF14652.6 EMC85485.1 - 0.094 11.9 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4457) DUF4481 PF14800.6 EMC85486.1 - 6.1e-56 190.1 3.8 6.6e-56 189.9 3.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4481) DUF2070 PF09843.9 EMC85486.1 - 0.017 13.5 1.0 0.019 13.3 1.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) CDP-OH_P_transf PF01066.21 EMC85486.1 - 0.084 13.7 0.6 0.18 12.6 0.6 1.6 1 1 0 1 1 1 0 CDP-alcohol phosphatidyltransferase NVEALA PF14055.6 EMC85486.1 - 0.19 11.8 2.2 1.4 9.0 0.3 2.2 2 0 0 2 2 2 0 NVEALA protein V-ATPase_G PF03179.15 EMC85487.1 - 9.1e-26 90.4 6.4 1.1e-25 90.2 6.4 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit Sec1 PF00995.23 EMC85488.1 - 1.1e-127 427.8 1.6 1.2e-127 427.6 1.6 1.0 1 0 0 1 1 1 1 Sec1 family YlbD_coat PF14071.6 EMC85488.1 - 0.031 14.5 0.8 0.097 12.9 0.8 1.8 1 0 0 1 1 1 0 Putative coat protein Ctr PF04145.15 EMC85490.1 - 8e-21 75.2 1.8 1e-20 74.9 1.8 1.1 1 0 0 1 1 1 1 Ctr copper transporter family Glyco_transf_43 PF03360.16 EMC85491.1 - 3e-26 92.5 0.0 3.3e-26 92.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 43 NUMOD1 PF07453.13 EMC85492.1 - 0.089 13.1 21.8 48 4.4 0.1 8.3 2 2 5 7 7 7 0 NUMOD1 domain DUF1593 PF07632.11 EMC85492.1 - 0.17 11.3 0.7 41 3.5 0.0 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1593) DUF656 PF04920.12 EMC85492.1 - 9.8 6.1 10.4 59 3.6 0.2 3.9 1 1 4 5 5 5 0 Family of unknown function (DUF656) 7tm_1 PF00001.21 EMC85496.1 - 6.9e-35 120.6 16.8 8.5e-35 120.3 16.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC85496.1 - 0.012 15.3 17.2 0.039 13.7 17.2 1.6 1 1 0 1 1 1 0 Olfactory receptor CbiN PF02553.15 EMC85497.1 - 7.7e-05 22.6 13.8 29 4.7 0.5 7.9 2 1 8 10 10 10 8 Cobalt transport protein component CbiN PH_RBD PF12068.8 EMC85497.1 - 0.074 12.5 5.7 26 4.2 1.3 4.0 1 1 2 3 3 3 0 Rab-binding domain (RBD) zf-CCCH PF00642.24 EMC85498.1 - 7.1e-09 35.4 17.6 0.00023 21.0 1.1 4.3 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 EMC85498.1 - 1.7e-07 31.4 4.3 3.3e-05 24.0 0.3 2.4 2 0 0 2 2 2 2 Zinc-finger containing family zf-CCCH_2 PF14608.6 EMC85498.1 - 0.00022 21.5 22.9 0.99 10.0 2.3 4.3 4 0 0 4 4 4 4 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 EMC85498.1 - 0.00034 20.3 2.7 0.00034 20.3 2.7 4.5 4 1 0 4 4 4 2 CCCH-type zinc finger Torus PF16131.5 EMC85498.1 - 0.0073 17.0 14.0 1.3 9.8 0.2 3.5 2 1 1 3 3 3 3 Torus domain zf_CCCH_4 PF18345.1 EMC85498.1 - 0.078 13.1 28.4 0.049 13.7 4.6 5.9 4 3 0 4 4 4 0 Zinc finger domain DUF1936 PF09151.10 EMC85498.1 - 0.1 12.5 4.2 5.6 7.0 0.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1936) 7tm_1 PF00001.21 EMC85499.1 - 2.3e-42 145.2 20.3 4e-42 144.4 20.3 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Pet100 PF09803.9 EMC85499.1 - 0.21 12.2 0.9 0.52 10.9 0.9 1.7 1 0 0 1 1 1 0 Pet100 DUF3671 PF12420.8 EMC85499.1 - 2.3 8.3 15.6 0.041 14.0 3.4 3.4 3 1 1 4 4 4 0 Protein of unknown function 7TM_GPCR_Srx PF10328.9 EMC85499.1 - 6.7 6.3 26.6 4 7.0 21.3 2.5 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx RhoGEF PF00621.20 EMC85500.1 - 1.1e-37 130.1 7.9 1.7e-37 129.4 7.9 1.4 1 0 0 1 1 1 1 RhoGEF domain SH3_9 PF14604.6 EMC85500.1 - 6.8e-12 45.1 0.1 1.3e-11 44.1 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC85500.1 - 2.6e-11 43.0 0.0 7.6e-11 41.4 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC85500.1 - 9.7e-10 38.0 0.0 2e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH_13 PF16652.5 EMC85500.1 - 0.014 15.2 0.6 0.85 9.4 0.1 2.7 2 0 0 2 2 2 0 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 EMC85500.1 - 0.021 14.8 0.3 0.11 12.4 0.0 2.2 2 0 0 2 2 2 0 PH domain Suppressor_P21 PF11479.8 EMC85500.1 - 0.04 14.1 1.3 0.28 11.4 0.2 2.6 2 0 0 2 2 2 0 RNA silencing suppressor P21 C-terminal domain DUF3336 PF11815.8 EMC85500.1 - 0.063 13.0 0.3 0.14 11.8 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3336) Lamprin PF06403.11 EMC85501.1 - 0.0012 18.8 1.8 0.16 11.9 0.7 2.1 1 1 1 2 2 2 2 Lamprin GLTT PF01744.20 EMC85501.1 - 0.039 13.7 8.8 4.8 7.1 0.1 3.5 1 1 2 4 4 4 0 GLTT repeat (6 copies) Sporozoite_P67 PF05642.11 EMC85501.1 - 0.12 10.4 1.3 0.22 9.6 1.3 1.6 1 1 0 1 1 1 0 Sporozoite P67 surface antigen Peptidase_M13_N PF05649.13 EMC85502.1 - 3.5e-119 398.9 2.4 5.8e-119 398.2 2.4 1.4 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 EMC85502.1 - 3.5e-72 242.3 0.1 6.8e-72 241.4 0.1 1.5 1 0 0 1 1 1 1 Peptidase family M13 AAA_23 PF13476.6 EMC85502.1 - 0.11 13.0 6.1 0.041 14.4 1.8 2.0 2 0 0 2 2 2 0 AAA domain PI-PLC-X PF00388.19 EMC85503.1 - 1e-63 213.3 0.0 2.3e-63 212.1 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EMC85503.1 - 5.8e-40 136.2 0.3 1.9e-39 134.6 0.3 2.0 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.11 EMC85503.1 - 1.2e-18 67.3 1.4 2.4e-18 66.4 0.3 2.1 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.30 EMC85503.1 - 4.5e-16 59.0 0.0 1.2e-15 57.6 0.0 1.7 1 0 0 1 1 1 1 C2 domain EF-hand_7 PF13499.6 EMC85503.1 - 5.5e-11 42.8 2.7 3.3e-10 40.2 0.4 2.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EMC85503.1 - 9.4e-10 37.3 2.4 2.8e-05 23.3 0.0 3.6 3 1 0 3 3 3 2 EF hand EF-hand_10 PF14788.6 EMC85503.1 - 3.7e-07 29.9 3.5 2.4e-06 27.3 0.2 3.5 3 1 1 4 4 4 2 EF hand EF-hand_6 PF13405.6 EMC85503.1 - 6.4e-07 28.8 1.0 0.016 15.1 0.0 3.9 3 0 0 3 3 3 2 EF-hand domain PH_12 PF16457.5 EMC85503.1 - 1.1e-06 29.2 0.0 2.9e-06 27.9 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain EF-hand_5 PF13202.6 EMC85503.1 - 9.9e-06 24.8 2.5 0.00033 20.0 0.1 3.0 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.6 EMC85503.1 - 6.1e-05 22.8 1.2 0.072 12.9 0.1 2.9 2 1 1 3 3 3 2 EF-hand domain pair PH PF00169.29 EMC85503.1 - 0.0027 18.2 0.0 0.0061 17.1 0.0 1.6 1 0 0 1 1 1 1 PH domain EF-hand_4 PF12763.7 EMC85503.1 - 0.031 14.2 0.1 0.1 12.5 0.1 1.9 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EMC85503.1 - 0.056 13.8 0.1 0.15 12.4 0.1 1.7 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region SNase PF00565.17 EMC85504.1 - 0.023 15.2 0.0 0.038 14.5 0.0 1.3 1 0 0 1 1 1 0 Staphylococcal nuclease homologue Acatn PF13000.7 EMC85505.1 - 7.6e-120 401.0 15.5 3.4e-71 240.4 7.7 3.1 1 1 1 2 2 2 2 Acetyl-coenzyme A transporter 1 Preseq_ALAS PF09029.10 EMC85506.1 - 0.0031 18.0 0.1 0.0039 17.7 0.1 1.2 1 0 0 1 1 1 1 5-aminolevulinate synthase presequence Aldo_ket_red PF00248.21 EMC85507.1 - 4.7e-30 104.8 0.0 6e-30 104.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 EMC85508.1 - 4.8e-15 55.5 0.0 5.4e-15 55.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF2685 PF10886.8 EMC85508.1 - 0.049 13.8 0.0 0.097 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2685) Ribonuc_red_2_N PF08471.10 EMC85508.1 - 0.11 12.6 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Class II vitamin B12-dependent ribonucleotide reductase PARP PF00644.20 EMC85509.1 - 1.3e-33 116.2 4.2 1e-32 113.4 4.2 2.1 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.20 EMC85509.1 - 3.9e-13 49.8 12.8 2.7e-09 37.5 0.9 2.9 3 0 0 3 3 3 2 WWE domain zf_CCCH_4 PF18345.1 EMC85509.1 - 0.00026 20.9 0.1 0.0011 19.0 0.1 2.2 1 0 0 1 1 1 1 Zinc finger domain Torus PF16131.5 EMC85509.1 - 0.026 15.2 0.0 0.067 13.9 0.0 1.7 1 0 0 1 1 1 0 Torus domain zf-CCCH PF00642.24 EMC85509.1 - 0.068 13.1 0.1 0.18 11.7 0.1 1.8 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) OmpH PF03938.14 EMC85510.1 - 0.0089 16.4 25.1 0.013 15.8 7.8 2.6 2 1 0 2 2 2 1 Outer membrane protein (OmpH-like) T3SSipB PF16535.5 EMC85510.1 - 0.033 14.7 12.8 0.16 12.4 1.8 2.3 2 0 0 2 2 2 0 Type III cell invasion protein SipB Wtap PF17098.5 EMC85510.1 - 0.035 14.1 25.7 0.041 13.8 19.6 3.0 1 1 1 2 2 2 0 WTAP/Mum2p family HMMR_N PF15905.5 EMC85510.1 - 0.086 12.3 35.9 0.036 13.5 21.9 2.1 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal APG6_N PF17675.1 EMC85510.1 - 0.15 12.6 37.4 0.81 10.2 16.5 2.4 1 1 0 2 2 2 0 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 EMC85510.1 - 0.22 11.6 36.2 0.045 13.8 13.4 3.3 2 2 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 EMC85510.1 - 0.28 10.0 33.5 0.24 10.3 11.8 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein Fib_alpha PF08702.10 EMC85510.1 - 0.29 11.3 22.6 0.095 12.9 4.6 3.2 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family IFT57 PF10498.9 EMC85510.1 - 0.43 9.5 27.4 0.35 9.8 7.9 2.3 1 1 0 2 2 2 0 Intra-flagellar transport protein 57 GAS PF13851.6 EMC85510.1 - 0.47 9.8 35.4 1.8 7.9 14.0 2.7 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding NPV_P10 PF05531.12 EMC85510.1 - 0.48 10.9 15.1 0.84 10.2 0.0 4.2 1 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF2203 PF09969.9 EMC85510.1 - 1.2 9.9 19.0 0.36 11.6 4.8 3.3 1 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) Fez1 PF06818.15 EMC85510.1 - 2.2 8.7 29.7 2.2 8.7 11.7 2.4 1 1 1 2 2 2 0 Fez1 LMBR1 PF04791.16 EMC85510.1 - 2.4 7.0 12.6 2.8 6.7 12.6 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein HOOK PF05622.12 EMC85510.1 - 2.8 6.0 32.0 6.7 4.7 32.0 1.5 1 1 0 1 1 1 0 HOOK protein UPF0242 PF06785.11 EMC85510.1 - 3.5 7.7 34.3 5 7.2 13.9 3.0 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus ATG16 PF08614.11 EMC85510.1 - 5.2 7.2 32.7 1.4 9.1 9.4 2.5 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) DHR10 PF18595.1 EMC85510.1 - 6.2 6.9 34.8 5.7 7.0 14.4 2.7 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain DUF3450 PF11932.8 EMC85510.1 - 7.4 5.8 25.2 0.75 9.1 5.4 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 EMC85510.1 - 7.9 6.5 18.2 5.7 7.0 2.7 3.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Tropomyosin_1 PF12718.7 EMC85510.1 - 8.6 6.5 34.5 3.2 7.9 12.6 2.6 2 1 0 2 2 2 0 Tropomyosin like Atg14 PF10186.9 EMC85510.1 - 9.1 5.3 26.6 2.5 7.1 8.9 2.3 2 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 RNR_Alpha PF17975.1 EMC85511.1 - 0.094 13.2 0.4 0.094 13.2 0.4 3.0 3 0 0 3 3 3 0 Ribonucleotide reductase alpha domain ParD_antitoxin PF03693.14 EMC85511.1 - 0.54 10.7 6.8 1.5 9.3 1.0 2.7 2 0 0 2 2 2 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH RasGAP_C PF03836.15 EMC85511.1 - 7.1 6.8 28.9 0.21 11.7 10.2 3.6 2 2 2 4 4 4 0 RasGAP C-terminus FAM76 PF16046.5 EMC85511.1 - 7.6 5.8 31.4 3.6 6.9 16.2 2.5 2 1 0 2 2 2 0 FAM76 protein PH PF00169.29 EMC85512.1 - 5.2e-11 43.0 1.8 5.6e-11 42.9 0.4 1.8 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 EMC85512.1 - 0.017 15.5 4.4 0.36 11.3 4.4 2.7 1 1 0 1 1 1 0 Pleckstrin homology domain PH_3 PF14593.6 EMC85512.1 - 0.058 13.5 0.1 0.12 12.5 0.1 1.5 1 0 0 1 1 1 0 PH domain PH_9 PF15410.6 EMC85512.1 - 0.065 13.6 0.5 0.18 12.2 0.5 1.9 1 1 0 1 1 1 0 Pleckstrin homology domain Pentaxin PF00354.17 EMC85513.1 - 2.7e-25 89.2 0.0 4.7e-25 88.4 0.0 1.3 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.6 EMC85513.1 - 3.9e-15 56.3 0.0 6e-15 55.7 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF438 PF04282.13 EMC85513.1 - 0.017 15.0 0.5 0.035 14.0 0.3 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF438) PQ-loop PF04193.14 EMC85514.1 - 7.1e-06 25.7 0.2 1.1e-05 25.1 0.2 1.4 1 0 0 1 1 1 1 PQ loop repeat PQ-loop PF04193.14 EMC85515.1 - 6.5e-17 61.1 0.6 6.5e-17 61.1 0.6 2.2 3 0 0 3 3 3 1 PQ loop repeat MtN3_slv PF03083.16 EMC85515.1 - 0.022 14.8 0.6 0.28 11.2 0.1 2.6 2 1 1 3 3 3 0 Sugar efflux transporter for intercellular exchange CcmD PF04995.14 EMC85515.1 - 4.8 7.3 8.1 3 8.0 0.1 3.0 3 1 0 3 3 3 0 Heme exporter protein D (CcmD) Homeodomain PF00046.29 EMC85516.1 - 3.8e-12 45.8 0.6 5.2e-12 45.4 0.6 1.2 1 0 0 1 1 1 1 Homeodomain MRP-S27 PF10037.9 EMC85517.1 - 0.01 14.7 3.4 0.017 14.0 3.4 1.3 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 Pro_CA PF00484.19 EMC85517.1 - 0.017 15.4 0.8 0.042 14.2 0.8 1.6 1 0 0 1 1 1 0 Carbonic anhydrase Mlf1IP PF10248.9 EMC85518.1 - 1.8e-75 252.7 8.3 2.1e-75 252.4 8.3 1.1 1 0 0 1 1 1 1 Myelodysplasia-myeloid leukemia factor 1-interacting protein GTP_EFTU PF00009.27 EMC85519.1 - 2.5e-64 216.4 0.0 3.8e-64 215.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EMC85519.1 - 5e-35 119.9 0.2 1.6e-34 118.3 0.1 2.0 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_II PF14492.6 EMC85519.1 - 8e-30 102.8 0.0 2e-29 101.5 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EMC85519.1 - 5.2e-25 87.3 0.1 1.2e-24 86.1 0.1 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EMC85519.1 - 1.3e-16 60.8 0.0 3.5e-16 59.4 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EMC85519.1 - 2.1e-07 30.8 0.0 1.2e-06 28.4 0.0 2.1 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 EMC85519.1 - 0.0018 18.3 0.1 0.0038 17.3 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EMC85519.1 - 0.018 14.4 0.0 0.035 13.4 0.0 1.4 1 0 0 1 1 1 0 AIG1 family SRPRB PF09439.10 EMC85519.1 - 0.14 11.6 0.0 0.49 9.8 0.0 1.8 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AvrPtoB_bdg PF16847.5 EMC85519.1 - 0.18 12.3 0.0 1.4 9.5 0.0 2.3 2 0 0 2 2 2 0 Avirulence AvrPtoB, BAK1-binding domain Latexin PF06907.12 EMC85520.1 - 6.7e-52 176.1 0.0 7.4e-52 176.0 0.0 1.0 1 0 0 1 1 1 1 Latexin Latexin PF06907.12 EMC85521.1 - 1.6e-70 237.0 0.1 1.8e-70 236.8 0.1 1.0 1 0 0 1 1 1 1 Latexin DUF3336 PF11815.8 EMC85521.1 - 0.063 13.0 0.3 0.5 10.1 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3336) MFS_1 PF07690.16 EMC85522.1 - 6.5e-40 137.1 66.5 3.6e-28 98.5 37.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EMC85522.1 - 4.1e-07 28.9 17.2 4.1e-07 28.9 17.2 2.7 1 1 2 3 3 3 1 MFS/sugar transport protein IQCJ-SCHIP1 PF15157.6 EMC85523.1 - 2.5e-49 167.1 4.2 2.8e-49 166.9 4.2 1.0 1 0 0 1 1 1 1 Fusion protein IQCJ-SCHIP1 with IQ-like motif IQ PF00612.27 EMC85523.1 - 0.014 15.1 0.1 0.027 14.3 0.1 1.4 1 0 0 1 1 1 0 IQ calmodulin-binding motif DUF2205 PF10224.9 EMC85523.1 - 0.55 10.3 4.5 0.35 10.9 2.3 1.8 1 1 1 2 2 2 0 Short coiled-coil protein SCHIP-1 PF10148.9 EMC85524.1 - 5.8e-90 301.0 13.6 6.5e-90 300.9 13.6 1.0 1 0 0 1 1 1 1 Schwannomin-interacting protein 1 FEZ PF07763.13 EMC85524.1 - 0.00024 20.9 9.4 0.00049 19.9 9.4 1.5 1 1 0 1 1 1 1 FEZ-like protein DUF5102 PF17104.5 EMC85524.1 - 0.0094 16.0 6.8 0.013 15.6 6.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5102) EURL PF06937.11 EMC85524.1 - 0.16 11.3 7.1 2.2 7.7 6.9 2.0 1 1 1 2 2 2 0 EURL protein ABC_tran_Xtn PF12848.7 EMC85524.1 - 5.1 7.2 7.4 2.1 8.4 3.8 1.9 2 0 0 2 2 2 0 ABC transporter FIIND PF13553.6 EMC85525.1 - 1.8e-25 89.8 0.0 2e-25 89.7 0.0 1.0 1 0 0 1 1 1 1 Function to find zf-RING_UBOX PF13445.6 EMC85526.1 - 5e-10 39.2 6.8 5e-10 39.2 6.8 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-B_box PF00643.24 EMC85526.1 - 1.5e-07 31.5 1.6 1.5e-07 31.5 1.6 2.7 2 0 0 2 2 2 1 B-box zinc finger zf-C3HC4_2 PF13923.6 EMC85526.1 - 9e-07 28.6 2.6 9e-07 28.6 2.6 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC85526.1 - 1.6e-06 27.9 6.7 1.6e-06 27.9 6.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) ANAPC4_WD40 PF12894.7 EMC85526.1 - 4.3e-06 26.9 0.2 0.32 11.3 0.0 4.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain zf-RING_5 PF14634.6 EMC85526.1 - 7.7e-06 25.8 5.5 7.7e-06 25.8 5.5 2.1 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EMC85526.1 - 9.2e-06 25.9 8.4 9.2e-06 25.9 8.4 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 EMC85526.1 - 2.1e-05 24.6 5.9 2.1e-05 24.6 5.9 2.8 2 1 1 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EMC85526.1 - 2.4e-05 24.1 5.1 2.4e-05 24.1 5.1 2.2 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) WD40 PF00400.32 EMC85526.1 - 0.0001 23.0 2.9 11 7.1 0.3 5.2 4 0 0 4 4 4 0 WD domain, G-beta repeat Prok-RING_4 PF14447.6 EMC85526.1 - 0.0021 17.9 6.9 0.0021 17.9 6.9 2.5 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 U-box PF04564.15 EMC85526.1 - 0.029 14.5 0.1 0.12 12.6 0.1 2.1 1 1 0 1 1 1 0 U-box domain zf-RING_11 PF17123.5 EMC85526.1 - 0.079 12.7 5.7 0.25 11.1 5.7 1.9 1 0 0 1 1 1 0 RING-like zinc finger DUF349 PF03993.12 EMC85526.1 - 0.098 13.0 2.5 0.34 11.2 2.5 2.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) zf-RING_10 PF16685.5 EMC85526.1 - 0.14 12.3 4.2 0.071 13.3 0.9 2.3 2 0 0 2 2 1 0 zinc RING finger of MSL2 Tachylectin PF14517.6 EMC85526.1 - 0.15 11.6 0.2 1.5 8.3 0.1 2.4 2 0 0 2 2 2 0 Tachylectin zf-RING_6 PF14835.6 EMC85526.1 - 0.36 10.7 6.6 0.065 13.1 2.4 1.9 2 0 0 2 2 1 0 zf-RING of BARD1-type protein Plk4_PB2 PF18409.1 EMC85526.1 - 0.71 10.6 2.8 2.1 9.1 2.8 1.8 1 0 0 1 1 1 0 Polo-like Kinase 4 Polo Box 2 Arm PF00514.23 EMC85527.1 - 1.1e-91 298.3 19.0 3e-13 49.3 0.2 9.2 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 EMC85527.1 - 3.5e-25 87.3 3.1 2.6e-23 81.3 3.2 2.5 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_EZ PF13513.6 EMC85527.1 - 4.4e-22 78.2 1.8 4.5e-09 36.6 0.1 6.0 5 1 1 6 6 6 3 HEAT-like repeat HEAT_2 PF13646.6 EMC85527.1 - 1.8e-19 69.9 0.7 2.9e-06 27.6 0.0 6.7 2 2 6 9 9 9 5 HEAT repeats HEAT PF02985.22 EMC85527.1 - 1.1e-17 62.6 5.1 0.0034 17.5 0.0 6.8 7 0 0 7 7 7 4 HEAT repeat IBB PF01749.20 EMC85527.1 - 1.1e-16 61.0 1.8 3e-16 59.6 1.8 1.8 1 0 0 1 1 1 1 Importin beta binding domain Adaptin_N PF01602.20 EMC85527.1 - 7.9e-08 31.3 1.9 5.6e-07 28.5 1.8 2.2 1 1 0 1 1 1 1 Adaptin N terminal region V-ATPase_H_C PF11698.8 EMC85527.1 - 3.7e-07 30.3 1.0 0.1 12.7 0.1 4.4 4 1 1 5 5 5 3 V-ATPase subunit H Cnd1 PF12717.7 EMC85527.1 - 2.1e-06 27.9 1.6 0.069 13.2 0.1 3.5 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_N PF03224.14 EMC85527.1 - 1.1e-05 24.9 1.4 0.00066 19.1 0.5 2.6 1 1 0 2 2 2 1 V-ATPase subunit H Arm_2 PF04826.13 EMC85527.1 - 9.2e-05 22.0 1.2 0.17 11.3 0.3 3.5 2 1 2 4 4 4 2 Armadillo-like Atx10homo_assoc PF09759.9 EMC85527.1 - 0.00038 20.4 1.2 0.55 10.3 0.0 4.8 3 1 1 5 5 5 1 Spinocerebellar ataxia type 10 protein domain DRIM PF07539.12 EMC85527.1 - 0.0048 15.3 0.8 0.79 8.0 0.1 2.4 1 1 1 2 2 2 2 Down-regulated in metastasis RasGEF_N_2 PF14663.6 EMC85527.1 - 0.012 16.1 0.5 14 6.1 0.0 3.9 3 2 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Mo25 PF08569.11 EMC85527.1 - 0.046 13.1 0.1 0.12 11.7 0.1 1.6 1 1 0 1 1 1 0 Mo25-like CTNNBL PF08216.11 EMC85527.1 - 0.093 12.9 4.3 6.9 6.9 0.1 3.9 4 1 0 4 4 4 0 Catenin-beta-like, Arm-motif containing nuclear MMS19_N PF14500.6 EMC85527.1 - 0.13 11.8 0.0 0.91 9.0 0.0 2.2 1 1 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II DUF4042 PF13251.6 EMC85527.1 - 0.29 10.8 1.8 2.3 7.9 0.3 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4042) Arf PF00025.21 EMC85528.1 - 2.4e-56 190.0 0.0 2.9e-56 189.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EMC85528.1 - 5.6e-15 55.3 1.4 7.5e-12 45.1 0.5 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 EMC85528.1 - 1e-12 48.3 0.0 1.5e-12 47.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMC85528.1 - 2.6e-12 46.6 0.0 3.3e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EMC85528.1 - 2.7e-08 33.5 0.0 3.7e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EMC85528.1 - 1.2e-07 31.4 0.0 1.5e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMC85528.1 - 1.2e-06 28.6 0.0 5.2e-06 26.5 0.0 2.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC85528.1 - 0.00011 21.8 0.0 0.00035 20.2 0.0 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 EMC85528.1 - 0.00068 18.7 0.0 0.11 11.4 0.0 2.7 1 1 2 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Galactosyl_T PF01762.21 EMC85529.1 - 7.7e-57 192.3 0.0 1e-56 191.8 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 EMC85529.1 - 1.1e-05 25.0 0.0 1.6e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Fringe-like PP2C PF00481.21 EMC85530.1 - 1.1e-57 195.6 0.0 1.4e-57 195.2 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EMC85530.1 - 6.3e-08 32.5 0.0 2.4e-07 30.6 0.0 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EMC85530.1 - 0.0021 18.0 0.0 0.17 11.8 0.0 2.2 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) SPT_ssu-like PF11779.8 EMC85531.1 - 1.8e-15 56.3 9.6 2.3e-15 55.9 9.6 1.1 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like NMD3 PF04981.13 EMC85532.1 - 2.1e-80 269.7 8.7 3.1e-80 269.2 8.7 1.2 1 0 0 1 1 1 1 NMD3 family TMEM37 PF15108.6 EMC85532.1 - 0.0058 16.5 0.1 0.011 15.6 0.1 1.4 1 0 0 1 1 1 1 Voltage-dependent calcium channel gamma-like subunit protein family DUF1221 PF06760.11 EMC85532.1 - 0.011 15.2 0.8 0.03 13.8 0.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1221) HEPN_Apea PF18739.1 EMC85532.1 - 0.064 13.7 0.1 0.47 10.9 0.1 2.2 1 1 1 2 2 2 0 Apea-like HEPN DUF1289 PF06945.13 EMC85532.1 - 0.078 12.8 2.9 6.1 6.7 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1289) DZR PF12773.7 EMC85532.1 - 2.8 8.1 12.6 54 3.9 12.6 2.7 1 1 0 1 1 1 0 Double zinc ribbon SPT_ssu-like PF11779.8 EMC85533.1 - 1.9e-15 56.2 6.7 2.3e-15 55.9 6.7 1.1 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like Collagen PF01391.18 EMC85534.1 - 3.9e-35 119.4 135.8 2.3e-08 33.6 31.1 5.1 1 1 2 3 3 3 2 Collagen triple helix repeat (20 copies) C1q PF00386.21 EMC85534.1 - 2.9e-32 111.5 0.0 3.7e-32 111.2 0.0 1.1 1 0 0 1 1 1 1 C1q domain DUF3421 PF11901.8 EMC85535.1 - 1.8e-15 57.0 2.5 5.2e-13 49.0 0.2 1.9 1 1 1 2 2 2 2 Protein of unknown function (DUF3421) zf-H2C2_2 PF13465.6 EMC85536.1 - 1.2e-41 139.3 41.2 9.8e-09 35.3 0.3 7.0 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.26 EMC85536.1 - 3.1e-35 118.7 33.6 4.6e-07 29.9 1.8 6.1 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC85536.1 - 6.3e-22 76.4 31.0 0.00054 20.6 0.6 6.1 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC85536.1 - 1.6e-18 66.5 4.4 0.0022 18.3 0.2 6.1 6 0 0 6 6 6 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC85536.1 - 5.1e-11 42.6 21.2 0.012 16.0 0.6 6.1 6 0 0 6 6 6 3 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EMC85536.1 - 9.9e-09 35.0 34.2 0.0031 17.5 1.8 6.2 6 0 0 6 6 6 3 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 EMC85536.1 - 8.7e-07 29.0 16.3 0.036 14.2 1.3 4.9 3 1 3 6 6 6 4 Zinc ribbon domain C1_4 PF07975.12 EMC85536.1 - 2.9e-06 27.4 12.5 0.014 15.6 2.1 3.8 1 1 4 5 5 5 4 TFIIH C1-like domain zf_UBZ PF18439.1 EMC85536.1 - 3e-06 26.7 11.2 1.8 8.3 0.1 6.0 6 0 0 6 6 6 1 Ubiquitin-Binding Zinc Finger DNA_RNApol_7kD PF03604.13 EMC85536.1 - 0.0014 18.3 20.2 4.1 7.2 0.1 6.1 6 0 0 6 6 6 2 DNA directed RNA polymerase, 7 kDa subunit zf-C2HC_2 PF13913.6 EMC85536.1 - 0.0014 18.5 2.8 0.011 15.6 0.7 5.3 6 0 0 6 6 5 2 zinc-finger of a C2HC-type zf-C2H2_3rep PF18868.1 EMC85536.1 - 0.0038 17.9 11.9 14 6.4 0.3 5.0 1 1 5 6 6 6 0 Zinc finger C2H2-type, 3 repeats zf-LYAR PF08790.11 EMC85536.1 - 0.0048 16.8 16.0 4.2 7.3 0.1 6.0 6 0 0 6 6 6 1 LYAR-type C2HC zinc finger zf-C2H2_11 PF16622.5 EMC85536.1 - 0.0051 16.6 1.0 0.0051 16.6 1.0 5.3 6 0 0 6 6 5 1 zinc-finger C2H2-type Zn_ribbon_SprT PF17283.2 EMC85536.1 - 0.0086 16.0 1.7 0.0086 16.0 1.7 4.3 4 1 0 4 4 4 1 SprT-like zinc ribbon domain Ta0938 PF11494.8 EMC85536.1 - 0.012 15.9 2.0 1 9.7 0.1 3.1 1 1 2 3 3 3 0 Ta0938 zinc_ribbon_15 PF17032.5 EMC85536.1 - 0.02 15.6 9.4 1.3 9.8 0.7 3.2 2 1 1 3 3 3 0 zinc-ribbon family zf-C2HE PF16278.5 EMC85536.1 - 0.044 14.2 22.3 0.54 10.7 0.3 5.5 1 1 4 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger zf-CHY PF05495.12 EMC85536.1 - 0.067 13.7 18.3 0.35 11.4 4.3 3.5 1 1 2 3 3 3 0 CHY zinc finger Zn_ribbon_recom PF13408.6 EMC85536.1 - 0.069 13.7 19.1 5.9 7.5 2.1 4.8 2 2 1 4 4 4 0 Recombinase zinc beta ribbon domain zf-AN1 PF01428.16 EMC85536.1 - 0.075 13.2 21.5 16 5.8 0.1 6.1 4 2 2 6 6 6 0 AN1-like Zinc finger Zf_RING PF16744.5 EMC85536.1 - 0.17 12.0 10.8 49 4.1 0.1 5.3 1 1 5 6 6 6 0 KIAA1045 RING finger DUF2256 PF10013.9 EMC85536.1 - 0.59 10.3 11.8 29 4.9 0.0 5.6 6 0 0 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2256) XPA_N PF01286.18 EMC85536.1 - 0.85 9.7 13.3 31 4.7 0.1 5.5 6 0 0 6 6 6 0 XPA protein N-terminal Sprouty PF05210.13 EMC85536.1 - 2.2 8.7 8.1 11 6.5 0.9 2.6 1 1 1 2 2 2 0 Sprouty protein (Spry) zf_ZIC PF18366.1 EMC85536.1 - 2.9 8.1 13.2 30 4.8 0.1 5.4 2 1 4 6 6 6 0 Zic proteins zinc finger domain zf_C2H2_ZHX PF18387.1 EMC85536.1 - 4.9 6.9 24.6 2.3 8.0 0.5 5.2 2 2 3 5 5 5 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_2 PF12756.7 EMC85536.1 - 5 7.5 16.6 21 5.5 0.2 5.1 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) LIM PF00412.22 EMC85536.1 - 6.3 7.1 14.7 21 5.4 0.8 4.6 1 1 4 5 5 5 0 LIM domain Parecho_VpG PF06344.11 EMC85537.1 - 2.2e-14 52.5 3.1 1e+02 3.9 0.0 10.7 10 0 0 10 10 10 0 Parechovirus Genome-linked protein PseudoU_synth_2 PF00849.22 EMC85537.1 - 0.0025 17.9 26.2 91 3.1 0.1 9.7 10 0 0 10 10 10 0 RNA pseudouridylate synthase PIGA PF08288.12 EMC85537.1 - 0.02 15.5 0.3 8.7e+02 0.6 0.0 5.4 1 1 9 10 10 10 0 PIGA (GPI anchor biosynthesis) Potassium_chann PF11404.8 EMC85537.1 - 0.18 11.6 31.2 99 2.9 0.1 10.1 11 0 0 11 11 11 0 Potassium voltage-gated channel DUF354 PF04007.12 EMC85538.1 - 0.0015 17.7 0.2 0.024 13.7 0.1 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF354) MbeD_MobD PF04899.12 EMC85538.1 - 0.012 15.7 0.0 4.3 7.5 0.0 3.0 1 1 1 2 2 2 0 MbeD/MobD like DUF948 PF06103.11 EMC85538.1 - 0.05 13.9 0.4 0.34 11.2 0.4 2.0 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) IKBKB_SDD PF18397.1 EMC85538.1 - 0.28 10.4 0.1 23 4.2 0.0 2.7 1 1 2 3 3 3 0 IQBAL scaffold dimerization domain Retro_M PF02813.14 EMC85539.1 - 2.2e-08 34.4 0.1 3.8e-08 33.6 0.1 1.4 1 0 0 1 1 1 1 Retroviral M domain TAFII28 PF04719.14 EMC85539.1 - 0.06 13.4 0.0 5.7 7.1 0.0 2.4 2 0 0 2 2 2 0 hTAFII28-like protein conserved region GLTT PF01744.20 EMC85540.1 - 0.0024 17.5 33.0 0.041 13.6 0.6 5.7 3 1 3 6 6 6 4 GLTT repeat (6 copies) Spc7_C2 PF15577.6 EMC85540.1 - 0.1 12.7 0.2 18 5.5 0.0 2.6 2 1 0 2 2 2 0 Spc7_C2 Neur_chan_LBD PF02931.23 EMC85541.1 - 1.5e-32 112.9 0.0 1.7e-32 112.6 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC85541.1 - 8.4e-19 68.6 3.8 1.1e-18 68.2 3.8 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Ras PF00071.22 EMC85544.1 - 3.7e-56 189.2 0.0 4.2e-56 189.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC85544.1 - 3.6e-23 82.1 0.0 5.4e-23 81.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC85544.1 - 3.1e-10 39.8 0.0 4.7e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EMC85544.1 - 0.023 14.1 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region SOAR PF16533.5 EMC85545.1 - 4.7e-43 145.3 2.9 4.7e-43 145.3 2.9 3.4 4 1 0 4 4 4 1 STIM1 Orai1-activating region SAM_2 PF07647.17 EMC85545.1 - 7.8e-09 35.5 0.2 5.3e-08 32.9 0.0 2.4 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EMC85545.1 - 2.6e-06 27.8 0.2 1.3e-05 25.6 0.1 2.3 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 EMC85545.1 - 0.038 14.2 0.0 0.088 13.1 0.0 1.7 1 0 0 1 1 1 0 Ste50p, sterile alpha motif MitMem_reg PF13012.6 EMC85545.1 - 4.2 7.8 8.5 97 3.4 6.7 3.2 2 1 0 2 2 2 0 Maintenance of mitochondrial structure and function Ribosomal_S20p PF01649.18 EMC85545.1 - 7.4 7.3 7.8 1.9 9.2 0.7 2.8 2 1 0 2 2 2 0 Ribosomal protein S20 Ribonuc_red_lgC PF02867.15 EMC85547.1 - 4.4e-193 642.6 0.0 5.1e-193 642.4 0.0 1.0 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EMC85547.1 - 4.1e-12 45.9 0.0 1.1e-11 44.6 0.0 1.8 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain 7tm_4 PF13853.6 EMC85548.1 - 1.3e-95 320.4 18.0 1.4e-95 320.2 18.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC85548.1 - 5.4e-23 81.6 12.8 7.2e-23 81.2 12.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC85548.1 - 1.3e-08 34.6 12.3 2.5e-08 33.6 12.2 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.9 EMC85548.1 - 0.00025 20.7 8.8 0.00038 20.0 8.8 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7TM_GPCR_Srx PF10328.9 EMC85548.1 - 0.96 9.0 14.7 0.055 13.1 9.2 1.6 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC85549.1 - 1.1e-86 291.0 19.4 1.4e-86 290.7 19.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC85549.1 - 2.1e-22 79.7 14.5 1.1e-21 77.3 14.5 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC85549.1 - 1.1e-10 41.4 9.6 1.4e-10 41.0 9.5 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.9 EMC85549.1 - 0.0043 16.6 6.8 0.0076 15.8 6.8 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7TM_GPCR_Srx PF10328.9 EMC85549.1 - 0.78 9.3 11.1 0.12 12.0 6.3 1.9 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC85550.1 - 3.1e-102 342.1 21.8 3.5e-102 341.9 21.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC85550.1 - 4.8e-20 72.0 18.3 7.7e-20 71.3 18.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC85550.1 - 3.7e-05 23.2 14.8 5.8e-05 22.6 14.5 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC85551.1 - 5.3e-105 351.1 13.2 6.2e-105 350.9 13.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC85551.1 - 4.6e-18 65.5 8.8 7.8e-18 64.7 8.8 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC85551.1 - 1.2e-07 31.4 5.7 2e-07 30.7 5.7 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC85552.1 - 3e-93 312.6 20.1 6.4e-53 180.3 7.8 2.0 2 0 0 2 2 2 2 Olfactory receptor 7tm_1 PF00001.21 EMC85552.1 - 2.7e-33 115.4 14.0 2.9e-18 66.2 7.4 2.2 2 0 0 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC85552.1 - 7.5e-17 61.6 13.8 2.4e-08 33.7 6.4 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.9 EMC85552.1 - 1.1e-05 25.1 21.7 0.0025 17.4 11.2 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srbc T4SS_CagC PF16943.5 EMC85552.1 - 0.13 12.5 3.2 0.92 9.7 0.3 2.4 2 0 0 2 2 2 0 Cag pathogenicity island, type IV secretory system 7tm_4 PF13853.6 EMC85553.1 - 4.8e-91 305.4 23.7 3e-48 165.0 4.6 2.1 2 0 0 2 2 2 2 Olfactory receptor 7tm_1 PF00001.21 EMC85553.1 - 6.3e-33 114.2 25.8 7.8e-18 64.7 14.4 2.2 2 0 0 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC85553.1 - 6.1e-21 74.9 22.5 5.2e-11 42.4 11.8 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.9 EMC85553.1 - 4.7e-06 26.3 27.5 0.0031 17.1 4.1 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srbc 7TM_GPCR_Srx PF10328.9 EMC85553.1 - 0.0097 15.6 31.7 0.12 11.9 4.9 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC85554.1 - 1.9e-96 323.1 21.5 2.2e-96 322.9 21.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC85554.1 - 9.2e-26 90.7 16.5 1.3e-25 90.3 16.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC85554.1 - 1.7e-10 40.7 15.0 2.4e-10 40.2 15.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC85554.1 - 0.0038 16.9 8.3 0.0038 16.9 8.3 1.8 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx ubiquitin PF00240.23 EMC85555.1 - 1.7e-11 43.7 0.1 3.6e-11 42.7 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EMC85555.1 - 8.2e-05 22.4 0.3 0.00029 20.7 0.3 2.0 1 0 0 1 1 1 1 UBA/TS-N domain Ubiquitin_5 PF18037.1 EMC85555.1 - 0.033 14.5 0.1 0.093 13.1 0.1 1.7 2 0 0 2 2 2 0 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EMC85555.1 - 0.035 14.2 0.0 0.067 13.3 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like STI1 PF17830.1 EMC85555.1 - 0.049 13.6 8.1 0.36 10.8 0.8 4.2 4 0 0 4 4 4 0 STI1 domain ORC_WH_C PF18137.1 EMC85555.1 - 0.073 13.1 0.9 0.19 11.8 0.9 1.6 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal HOIP-UBA PF16678.5 EMC85555.1 - 0.1 12.6 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 HOIP UBA domain pair Rad60-SLD PF11976.8 EMC85555.1 - 0.11 12.4 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like 7tm_4 PF13853.6 EMC85556.1 - 4.8e-118 393.9 17.8 5.4e-118 393.8 17.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC85556.1 - 4.3e-27 95.1 17.0 5.6e-27 94.7 17.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC85556.1 - 3.4e-10 39.8 7.0 6.1e-10 38.9 7.0 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Ribosomal_S17 PF00366.20 EMC85558.1 - 4.3e-29 100.4 1.6 5.6e-29 100.1 1.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S17 Ribosomal_S17_N PF16205.5 EMC85558.1 - 1.3e-13 51.1 0.1 1.3e-13 51.1 0.1 2.1 3 0 0 3 3 3 1 Ribosomal_S17 N-terminal PRF PF06875.11 EMC85558.1 - 0.051 13.0 0.1 0.08 12.4 0.1 1.2 1 0 0 1 1 1 0 Plethodontid receptivity factor PRF Cadherin PF00028.17 EMC85560.1 - 7.7e-85 279.5 1.3 1e-17 64.4 0.0 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 EMC85560.1 - 3.2e-55 186.4 0.0 7.6e-55 185.2 0.0 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_4 PF17803.1 EMC85560.1 - 2.1e-08 34.7 10.5 0.0013 19.3 0.1 4.2 4 0 0 4 4 4 2 Bacterial cadherin-like domain Cadherin_2 PF08266.12 EMC85560.1 - 1.1e-05 25.2 0.0 0.75 9.7 0.0 3.9 3 0 0 3 3 3 2 Cadherin-like Cadherin_3 PF16184.5 EMC85560.1 - 0.00052 20.0 7.6 2.5 8.1 0.1 5.4 6 0 0 6 6 6 1 Cadherin-like Big_9 PF17963.1 EMC85560.1 - 0.003 18.3 8.4 1.2 10.0 0.8 4.1 3 0 0 3 3 3 2 Bacterial Ig domain Cadherin_pro PF08758.11 EMC85560.1 - 0.052 13.7 0.0 4 7.7 0.0 2.8 2 0 0 2 2 2 0 Cadherin prodomain like Invasin_D3 PF09134.10 EMC85560.1 - 0.18 12.2 0.9 4.5 7.6 0.0 3.4 3 1 0 3 3 3 0 Invasin, domain 3 DUF5527 PF17665.1 EMC85560.1 - 0.35 10.4 1.5 0.68 9.5 1.5 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5527) TSP_1 PF00090.19 EMC85561.1 - 8.1e-12 45.2 47.5 6.3e-06 26.3 6.8 4.5 4 2 0 4 4 4 3 Thrombospondin type 1 domain PLAC PF08686.11 EMC85561.1 - 1.3e-11 45.0 8.8 1.3e-11 45.0 8.8 3.0 3 0 0 3 3 3 1 PLAC (protease and lacunin) domain Pribosyltran PF00156.27 EMC85562.1 - 1e-13 51.1 0.0 2.6e-13 49.8 0.0 1.6 1 1 0 1 1 1 1 Phosphoribosyl transferase domain NUDIX PF00293.28 EMC85563.1 - 4.1e-09 36.6 0.0 6.5e-09 35.9 0.0 1.3 1 1 0 1 1 1 1 NUDIX domain ADH_zinc_N_2 PF13602.6 EMC85564.1 - 9.5e-14 52.6 0.0 2.3e-13 51.3 0.0 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EMC85564.1 - 6.3e-10 39.1 0.0 1.4e-09 38.1 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMC85564.1 - 5.3e-08 32.7 0.0 1.1e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Lectin_C PF00059.21 EMC85565.1 - 1.8e-18 67.2 0.1 2.9e-18 66.6 0.1 1.3 1 0 0 1 1 1 1 Lectin C-type domain Chordopox_A33R PF05966.12 EMC85565.1 - 0.0021 17.3 0.0 0.0032 16.8 0.0 1.2 1 0 0 1 1 1 1 Chordopoxvirus A33R protein BUD22 PF09073.10 EMC85565.1 - 0.058 12.7 0.7 0.066 12.5 0.7 1.1 1 0 0 1 1 1 0 BUD22 GPS PF01825.21 EMC85565.1 - 0.14 12.7 0.7 0.34 11.5 0.7 1.7 1 0 0 1 1 1 0 GPCR proteolysis site, GPS, motif adh_short PF00106.25 EMC85566.1 - 1.8e-28 99.3 0.0 6.1e-24 84.6 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMC85566.1 - 1.5e-17 64.0 0.0 1e-15 57.9 0.0 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC85566.1 - 1.6e-09 37.9 0.1 2.4e-09 37.4 0.1 1.2 1 0 0 1 1 1 1 KR domain WW PF00397.26 EMC85566.1 - 7.1e-08 32.4 6.8 3.6e-07 30.2 0.4 2.6 2 0 0 2 2 2 1 WW domain Epimerase PF01370.21 EMC85566.1 - 0.011 15.2 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EMC85566.1 - 0.012 15.9 0.0 0.46 10.8 0.1 2.3 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Pyr_redox_3 PF13738.6 EMC85566.1 - 0.049 12.9 0.0 0.069 12.4 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase YjeF_N PF03853.15 EMC85566.1 - 0.073 12.9 0.1 0.12 12.3 0.1 1.3 1 0 0 1 1 1 0 YjeF-related protein N-terminus RmlD_sub_bind PF04321.17 EMC85566.1 - 0.094 11.8 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain PerB PF06590.11 EMC85566.1 - 0.13 12.7 0.0 0.32 11.5 0.0 1.6 2 0 0 2 2 2 0 PerB protein Exo_endo_phos PF03372.23 EMC85568.1 - 1.2e-05 25.0 0.0 0.00013 21.6 0.0 2.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family CBM_6 PF03422.15 EMC85568.1 - 0.033 14.5 0.1 0.088 13.1 0.1 1.7 1 0 0 1 1 1 0 Carbohydrate binding module (family 6) SCPU PF05229.15 EMC85568.1 - 0.12 12.8 0.5 8.3 6.8 0.0 2.6 2 0 0 2 2 2 0 Spore Coat Protein U domain LCAT PF02450.15 EMC85570.1 - 1.7e-86 290.8 0.6 1.7e-84 284.3 0.6 2.1 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF915 PF06028.11 EMC85570.1 - 7.6e-06 25.4 0.3 0.053 12.9 0.1 2.1 2 0 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_6 PF12697.7 EMC85570.1 - 0.00018 22.2 0.0 0.00024 21.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMC85570.1 - 0.035 13.4 0.0 0.054 12.8 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF900 PF05990.12 EMC85570.1 - 0.098 12.2 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) PGAP1 PF07819.13 EMC85570.1 - 0.098 12.4 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein 7tm_1 PF00001.21 EMC85571.1 - 6.4e-47 160.1 24.8 6.4e-47 160.1 24.8 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC85571.1 - 1.4e-07 31.2 27.3 1.7e-07 30.9 26.6 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC85571.1 - 0.00012 21.8 22.7 0.00012 21.8 22.7 2.4 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx TMEM132D_C PF15706.5 EMC85571.1 - 5.2 6.9 8.3 17 5.2 2.2 2.8 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term RRM_1 PF00076.22 EMC85572.1 - 8.5e-14 51.1 0.0 0.011 15.5 0.0 4.2 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RHD_dimer PF16179.5 EMC85573.1 - 1.6e-25 89.1 0.1 3.3e-25 88.1 0.1 1.6 1 0 0 1 1 1 1 Rel homology dimerisation domain RHD_DNA_bind PF00554.22 EMC85573.1 - 5.6e-23 81.7 0.2 2.1e-22 79.9 0.2 1.9 1 1 0 1 1 1 1 Rel homology DNA-binding domain TIG PF01833.24 EMC85573.1 - 3.4e-06 27.0 0.8 1.4e-05 25.1 0.1 2.5 2 1 0 2 2 2 1 IPT/TIG domain Helicase_C PF00271.31 EMC85574.1 - 1.4e-27 96.2 0.0 2.1e-27 95.7 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain 7tm_1 PF00001.21 EMC85575.1 - 6.6e-56 189.5 15.4 7.7e-56 189.3 15.4 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 EMC85575.1 - 7.5e-08 32.1 14.8 1e-07 31.7 14.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srw PF10324.9 EMC85575.1 - 1.2e-07 31.3 15.3 1.2e-06 28.1 15.3 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.6 EMC85575.1 - 3.7e-07 30.2 11.2 5.1e-07 29.7 11.2 1.2 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC85575.1 - 5.7e-06 26.1 15.7 1.1e-05 25.2 15.7 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srd PF10317.9 EMC85575.1 - 0.01 15.1 18.7 0.045 12.9 18.7 1.9 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srd DUF898 PF05987.13 EMC85575.1 - 0.12 11.4 12.3 0.089 11.8 8.9 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF898) Abhydrolase_9_N PF15420.6 EMC85575.1 - 0.57 10.2 10.7 0.6 10.1 4.8 2.1 1 1 1 2 2 2 0 Alpha/beta-hydrolase family N-terminus Peptidase_M19 PF01244.21 EMC85576.1 - 5e-105 351.2 0.0 5.7e-105 351.0 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) SNF PF00209.18 EMC85577.1 - 1.6e-237 789.4 34.5 1.8e-237 789.2 34.5 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Ig_2 PF13895.6 EMC85578.1 - 0.025 14.9 1.5 9.2 6.7 0.2 2.9 1 1 2 3 3 3 0 Immunoglobulin domain LAMTOR5 PF16672.5 EMC85578.1 - 0.032 14.1 1.1 27 4.8 0.0 3.6 1 1 3 4 4 4 0 Ragulator complex protein LAMTOR5 ResIII PF04851.15 EMC85578.1 - 0.064 13.2 0.9 3.2 7.7 0.4 2.6 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit ZapC PF07126.12 EMC85578.1 - 0.14 11.7 0.0 7.2 6.2 0.0 2.1 1 1 1 2 2 2 0 Cell-division protein ZapC MSA_2 PF00985.17 EMC85578.1 - 6.2 7.1 9.3 4.1 7.7 1.0 2.5 1 1 2 3 3 3 0 Merozoite Surface Antigen 2 (MSA-2) family DUF3668 PF12416.8 EMC85579.1 - 1.1e-92 310.0 0.0 1.1e-92 310.0 0.0 2.8 2 0 0 2 2 2 1 Cep120 protein C2 PF00168.30 EMC85579.1 - 1.5e-07 31.6 0.0 0.0064 16.8 0.0 3.5 3 0 0 3 3 3 2 C2 domain Pkinase PF00069.25 EMC85580.1 - 5.6e-21 75.1 0.0 6e-21 75.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC85580.1 - 5.1e-11 42.4 0.0 5.7e-11 42.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC85580.1 - 1.4e-08 34.0 0.1 1.7e-08 33.7 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase Spot_14 PF07084.12 EMC85580.1 - 0.05 13.7 0.0 0.068 13.3 0.0 1.2 1 0 0 1 1 1 0 Thyroid hormone-inducible hepatic protein Spot 14 FAM27 PF15832.5 EMC85581.1 - 5.9 7.5 15.1 2.1 8.9 6.0 3.9 3 0 0 3 3 3 0 FAM27 D and E protein family GRAM PF02893.20 EMC85582.1 - 3e-18 65.8 0.6 7e-18 64.6 0.2 1.8 2 0 0 2 2 2 1 GRAM domain Aldedh PF00171.22 EMC85583.1 - 1.9e-131 438.8 0.0 2.2e-131 438.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family OmdA PF13376.6 EMC85583.1 - 0.047 13.7 0.3 0.19 11.8 0.1 1.9 2 0 0 2 2 2 0 Bacteriocin-protection, YdeI or OmpD-Associated Tti2 PF10521.9 EMC85584.1 - 0.081 12.5 0.0 0.1 12.1 0.0 1.1 1 0 0 1 1 1 0 Tti2 family Pkinase PF00069.25 EMC85586.1 - 3.3e-70 236.5 0.0 4.8e-70 235.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC85586.1 - 1.2e-25 90.3 0.0 2.2e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EMC85586.1 - 0.0063 16.5 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family PLDc_3 PF13918.6 EMC85587.1 - 1e-35 123.0 0.0 2.3e-35 121.9 0.0 1.6 2 0 0 2 2 2 1 PLD-like domain PLDc_2 PF13091.6 EMC85587.1 - 8.1e-28 97.0 0.0 4.2e-14 52.6 0.0 2.1 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EMC85587.1 - 2.8e-13 49.4 3.6 4.2e-09 36.2 0.7 2.4 2 0 0 2 2 2 2 Phospholipase D Active site motif Pkinase PF00069.25 EMC85588.1 - 2.4e-25 89.4 0.0 2.5e-25 89.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC85588.1 - 4.4e-10 39.3 0.0 4.7e-10 39.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EMC85588.1 - 0.0019 18.2 0.0 0.0023 17.9 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EMC85588.1 - 0.0037 16.3 0.1 0.0042 16.1 0.1 1.1 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase Kdo PF06293.14 EMC85588.1 - 0.011 15.1 0.0 0.013 14.8 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMC85588.1 - 0.12 11.1 0.0 0.14 10.9 0.0 1.0 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 EMC85588.1 - 0.13 11.6 0.0 0.18 11.1 0.0 1.4 1 1 0 1 1 1 0 Kinase-like RIO1 PF01163.22 EMC85588.1 - 0.14 11.8 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 RIO1 family DUF1180 PF06679.12 EMC85589.1 - 6.3e-26 91.8 3.6 6.4e-26 91.8 3.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) Mpv17_PMP22 PF04117.12 EMC85591.1 - 2.2e-15 56.6 1.3 4.3e-15 55.7 1.3 1.5 1 1 0 1 1 1 1 Mpv17 / PMP22 family MLIP PF15274.6 EMC85591.1 - 0.067 13.1 0.3 0.1 12.5 0.3 1.2 1 0 0 1 1 1 0 Muscular LMNA-interacting protein N_Asn_amidohyd PF14736.6 EMC85592.1 - 1.5e-121 404.7 0.0 1.7e-121 404.5 0.0 1.0 1 0 0 1 1 1 1 Protein N-terminal asparagine amidohydrolase RRN3 PF05327.11 EMC85593.1 - 1.7e-132 442.9 1.2 1.9e-132 442.7 1.2 1.0 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 PMD PF10536.9 EMC85593.1 - 0.12 11.5 0.0 2.3 7.3 0.0 2.1 2 0 0 2 2 2 0 Plant mobile domain Ribosomal_L1 PF00687.21 EMC85594.1 - 1.8e-51 174.8 1.1 1.8e-51 174.8 1.1 2.7 3 0 0 3 3 3 2 Ribosomal protein L1p/L10e family HutP PF09021.11 EMC85594.1 - 3.3 8.0 5.3 36 4.7 0.2 3.0 3 0 0 3 3 3 0 HutP GTP_EFTU PF00009.27 EMC85595.1 - 7.2e-47 159.4 0.0 1.4e-46 158.5 0.0 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EMC85595.1 - 3.4e-32 111.1 0.2 3.4e-32 111.1 0.2 2.9 5 0 0 5 5 5 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EMC85595.1 - 7.4e-08 32.7 0.1 2.3e-07 31.1 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EMC85595.1 - 0.00061 19.9 0.1 0.0028 17.7 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 EMC85595.1 - 0.061 12.8 0.0 1.5 8.3 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family LPD34 PF18852.1 EMC85595.1 - 0.065 12.8 0.1 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 Large polyvalent protein associated domain 34 BCMA-Tall_bind PF09257.10 EMC85596.1 - 0.0009 19.3 0.7 0.0026 17.8 0.7 1.8 1 0 0 1 1 1 1 BCMA, TALL-1 binding RUN PF02759.19 EMC85597.1 - 1.8e-24 86.2 0.1 3.3e-24 85.4 0.1 1.5 1 0 0 1 1 1 1 RUN domain UPF0054 PF02130.17 EMC85597.1 - 0.035 13.9 0.2 0.098 12.5 0.1 1.8 2 0 0 2 2 2 0 Uncharacterized protein family UPF0054 PX PF00787.24 EMC85598.1 - 1.2e-18 67.2 1.0 1.2e-18 67.2 1.0 2.2 3 0 0 3 3 3 1 PX domain Rootletin PF15035.6 EMC85598.1 - 0.0058 16.7 2.4 0.0058 16.7 2.4 2.7 3 1 0 3 3 3 1 Ciliary rootlet component, centrosome cohesion Phage_GP20 PF06810.11 EMC85598.1 - 0.016 15.0 1.3 0.016 15.0 1.3 1.9 3 0 0 3 3 3 0 Phage minor structural protein GP20 TSC22 PF01166.18 EMC85598.1 - 0.02 15.2 10.0 0.04 14.2 3.0 2.9 1 1 1 2 2 2 0 TSC-22/dip/bun family FUSC PF04632.12 EMC85598.1 - 0.068 11.7 2.9 0.12 10.9 2.9 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family kleA_kleC PF17383.2 EMC85598.1 - 0.075 13.4 3.0 0.18 12.2 3.0 1.6 1 0 0 1 1 1 0 Uncharacterized KorC regulated protein A RasGAP_C PF03836.15 EMC85598.1 - 0.33 11.1 7.9 12 6.0 0.1 3.5 1 1 3 4 4 4 0 RasGAP C-terminus bZIP_1 PF00170.21 EMC85598.1 - 0.68 10.1 13.1 1.1 9.4 1.3 3.2 3 0 0 3 3 3 0 bZIP transcription factor OrfB_IS605 PF01385.19 EMC85598.1 - 2.2 8.6 5.7 0.37 11.0 0.5 2.3 3 0 0 3 3 3 0 Probable transposase PXA PF02194.15 EMC85598.1 - 4.8 7.1 7.1 50 3.8 7.1 2.1 1 1 0 1 1 1 0 PXA domain NYD-SP28_assoc PF14775.6 EMC85598.1 - 8.6 6.6 12.8 2 8.6 1.1 3.6 4 0 0 4 4 4 0 Sperm tail C-terminal domain DUF2203 PF09969.9 EMC85598.1 - 9 7.0 10.3 51 4.6 5.2 2.8 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) Metallophos PF00149.28 EMC85599.1 - 1.9e-15 57.9 0.9 3.2e-15 57.2 0.9 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ERCC4 PF02732.15 EMC85600.1 - 1.3e-24 87.2 0.0 2.9e-24 86.0 0.0 1.6 1 0 0 1 1 1 1 ERCC4 domain HHH_5 PF14520.6 EMC85600.1 - 0.00036 21.1 0.0 0.0014 19.2 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain DUF4110 PF13422.6 EMC85600.1 - 1.7 8.8 7.7 0.09 12.9 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4110) RPEL PF02755.15 EMC85601.1 - 3.9e-21 74.0 15.2 2.2e-08 33.5 0.1 4.2 4 0 0 4 4 4 3 RPEL repeat SAP PF02037.27 EMC85601.1 - 5.5e-12 45.1 3.5 6.3e-12 45.0 0.3 2.4 2 0 0 2 2 2 1 SAP domain MPS2 PF17060.5 EMC85601.1 - 0.00075 18.9 1.8 0.0015 17.8 1.8 1.4 1 0 0 1 1 1 1 Monopolar spindle protein 2 Spc29 PF17082.5 EMC85601.1 - 0.0026 17.7 1.9 0.0088 15.9 1.9 1.9 1 0 0 1 1 1 1 Spindle Pole Component 29 CSN5_C PF18323.1 EMC85601.1 - 0.17 12.8 4.1 1 10.3 4.1 2.4 1 0 0 1 1 1 0 Cop9 signalosome subunit 5 C-terminal domain V_ATPase_I PF01496.19 EMC85601.1 - 0.78 7.6 5.1 1.5 6.7 5.1 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fib_alpha PF08702.10 EMC85601.1 - 1.4 9.1 9.1 1.2 9.3 3.1 2.7 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family HIP1_clath_bdg PF16515.5 EMC85601.1 - 4.2 8.0 17.3 0.43 11.2 7.8 3.4 3 0 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CAF1 PF04857.20 EMC85602.1 - 4.6e-89 298.7 2.7 4.6e-89 298.7 2.7 1.7 2 0 0 2 2 2 1 CAF1 family ribonuclease RNA_bind PF08675.11 EMC85602.1 - 1.2e-33 114.9 0.2 2.3e-33 114.0 0.2 1.5 1 0 0 1 1 1 1 RNA binding domain R3H PF01424.22 EMC85602.1 - 1.3e-06 28.3 0.0 4.3e-06 26.6 0.0 2.0 1 0 0 1 1 1 1 R3H domain NCBP3 PF10309.9 EMC85602.1 - 0.013 15.3 0.1 0.03 14.2 0.1 1.6 1 0 0 1 1 1 0 Nuclear cap-binding protein subunit 3 RRM_1 PF00076.22 EMC85602.1 - 0.029 14.2 0.0 0.074 12.9 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LUD_dom PF02589.15 EMC85602.1 - 0.061 13.0 0.1 0.2 11.4 0.0 1.9 2 0 0 2 2 2 0 LUD domain SAM_1 PF00536.30 EMC85603.1 - 1.8e-11 44.3 0.0 3.4e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-C3HC4_4 PF15227.6 EMC85603.1 - 2.5e-08 33.9 12.3 6.3e-08 32.7 12.3 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 EMC85603.1 - 2.8e-08 33.5 13.1 5.4e-08 32.6 13.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC85603.1 - 6.8e-08 32.2 13.2 1.3e-07 31.3 13.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SAM_2 PF07647.17 EMC85603.1 - 9.6e-07 28.8 0.0 1.9e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-RING_UBOX PF13445.6 EMC85603.1 - 3.6e-06 26.9 10.6 1.1e-05 25.4 10.6 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EMC85603.1 - 3.8e-06 26.7 8.0 6.4e-06 25.9 8.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC85603.1 - 2.4e-05 24.6 14.4 5.2e-05 23.5 14.4 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_4 PF14570.6 EMC85603.1 - 0.016 15.0 5.0 0.016 15.0 5.0 2.6 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 EMC85603.1 - 0.02 15.0 4.5 0.045 13.8 4.5 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger SAM_PNT PF02198.16 EMC85603.1 - 0.021 14.8 0.2 0.061 13.3 0.2 1.8 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain zf-RING_5 PF14634.6 EMC85603.1 - 0.026 14.5 11.1 0.056 13.4 11.1 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_10 PF16685.5 EMC85603.1 - 0.042 14.0 6.8 0.097 12.8 6.8 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 EMC85603.1 - 0.059 13.2 10.2 0.14 12.0 10.2 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EMC85603.1 - 0.063 13.6 11.0 0.15 12.4 11.0 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain DUF1435 PF07256.12 EMC85603.1 - 0.12 12.5 1.3 0.26 11.4 0.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1435) Phospholip_A2_1 PF00068.19 EMC85604.1 - 1.6e-34 118.7 15.0 1.9e-34 118.5 15.0 1.1 1 0 0 1 1 1 1 Phospholipase A2 TPR_1 PF00515.28 EMC85605.1 - 1.8e-05 24.3 4.5 0.0042 16.9 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat zf-CCCH PF00642.24 EMC85605.1 - 2.3e-05 24.2 1.8 2.3e-05 24.2 1.8 4.2 4 0 0 4 4 4 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EMC85605.1 - 0.00017 21.5 1.8 0.00017 21.5 1.8 4.1 3 0 0 3 3 3 1 Zinc finger domain zf-CCCH_4 PF18044.1 EMC85605.1 - 0.0019 18.0 1.3 0.0019 18.0 1.3 4.8 4 0 0 4 4 4 2 CCCH-type zinc finger zf-C2H2_jaz PF12171.8 EMC85605.1 - 0.0019 18.4 6.7 0.0019 18.4 6.7 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding TPR_2 PF07719.17 EMC85605.1 - 0.013 15.5 2.4 0.5 10.6 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-met PF12874.7 EMC85605.1 - 0.023 15.1 6.3 0.098 13.1 6.3 2.2 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EMC85605.1 - 0.024 15.0 1.9 0.024 15.0 1.9 2.5 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Phage-scaffold PF09306.10 EMC85605.1 - 0.045 13.1 0.2 0.085 12.2 0.2 1.4 1 0 0 1 1 1 0 Bacteriophage, scaffolding protein TPR_11 PF13414.6 EMC85605.1 - 0.062 13.0 0.3 7.2 6.4 0.0 2.5 2 0 0 2 2 2 0 TPR repeat Thioredoxin PF00085.20 EMC85606.1 - 6.5e-23 80.7 0.0 2.4e-11 43.5 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 EMC85606.1 - 3.5e-06 27.0 0.0 0.039 13.9 0.0 3.7 3 1 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 EMC85606.1 - 0.00016 21.8 1.3 0.061 13.5 0.1 2.9 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_8 PF13905.6 EMC85606.1 - 0.00071 19.9 0.2 0.18 12.1 0.1 3.3 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EMC85606.1 - 0.0075 16.7 0.3 5 7.6 0.0 3.2 2 1 0 2 2 2 1 Thioredoxin-like domain DUF16 PF01519.16 EMC85606.1 - 0.025 15.0 8.6 0.043 14.3 7.5 2.0 2 0 0 2 2 1 0 Protein of unknown function DUF16 DUF836 PF05768.14 EMC85606.1 - 0.028 14.8 0.0 0.11 12.9 0.0 2.1 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) DUF2992 PF11208.8 EMC85606.1 - 0.12 12.6 8.9 0.24 11.6 8.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) Atthog PF18800.1 EMC85606.1 - 0.15 11.9 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 Attenuator of Hedgehog ERM PF00769.19 EMC85606.1 - 0.2 11.4 28.4 0.31 10.8 28.4 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Atg14 PF10186.9 EMC85606.1 - 0.31 10.1 17.2 0.86 8.6 17.2 1.7 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 V_ATPase_I PF01496.19 EMC85606.1 - 0.33 8.8 10.2 0.56 8.1 10.2 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GPS2_interact PF15784.5 EMC85606.1 - 0.42 11.1 13.1 0.16 12.4 10.0 1.9 1 1 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain HAUS-augmin3 PF14932.6 EMC85606.1 - 0.43 10.1 21.5 0.86 9.1 21.5 1.5 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Fmp27_WPPW PF10359.9 EMC85606.1 - 0.89 8.3 12.8 1.5 7.6 12.8 1.3 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Tho2 PF11262.8 EMC85606.1 - 1.2 8.3 10.6 2 7.6 10.6 1.3 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 USP8_interact PF08941.10 EMC85606.1 - 1.4 8.7 7.1 2.5 7.9 7.1 1.5 1 0 0 1 1 1 0 USP8 interacting KASH_CCD PF14662.6 EMC85606.1 - 1.8 8.3 28.5 6.6 6.5 26.9 2.1 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH GAS PF13851.6 EMC85606.1 - 2.5 7.4 26.3 4.2 6.7 26.3 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 EMC85606.1 - 2.8 8.5 32.0 0.92 10.0 28.4 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region Exonuc_VII_L PF02601.15 EMC85606.1 - 2.9 7.4 14.8 4.6 6.7 14.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Macoilin PF09726.9 EMC85606.1 - 3.7 6.0 22.7 1.7 7.1 20.5 1.4 1 1 0 1 1 1 0 Macoilin family FUSC PF04632.12 EMC85606.1 - 7.5 4.9 11.0 12 4.3 11.0 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family rve PF00665.26 EMC85607.1 - 0.002 18.3 0.0 0.0026 17.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Zona_pellucida PF00100.23 EMC85608.1 - 1.9e-43 149.1 2.3 2.3e-43 148.8 2.3 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain Neurexophilin PF06312.12 EMC85609.1 - 8.2e-47 159.4 0.0 1.4e-46 158.7 0.0 1.3 1 0 0 1 1 1 1 Neurexophilin Filamin PF00630.19 EMC85609.1 - 9.8e-05 23.1 0.0 0.0002 22.1 0.0 1.4 1 0 0 1 1 1 1 Filamin/ABP280 repeat CD20 PF04103.15 EMC85609.1 - 0.15 12.2 0.1 0.25 11.4 0.1 1.3 1 0 0 1 1 1 0 CD20-like family LRR_9 PF14580.6 EMC85610.1 - 1.5e-20 73.4 1.9 7.8e-16 58.1 0.0 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 EMC85610.1 - 1.1e-15 57.5 25.4 2.1e-05 24.8 3.9 4.9 5 0 0 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMC85610.1 - 4.3e-13 48.8 27.2 2.3e-06 27.3 3.7 4.1 1 1 3 4 4 4 4 Leucine rich repeat IQ PF00612.27 EMC85610.1 - 0.00089 18.8 0.1 0.0022 17.6 0.1 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif LRR_6 PF13516.6 EMC85610.1 - 0.0017 18.3 11.2 0.21 11.7 0.5 5.9 5 0 0 5 5 5 1 Leucine Rich repeat LRR_1 PF00560.33 EMC85610.1 - 0.17 12.6 14.7 1.7 9.5 0.2 5.8 5 1 1 6 6 6 0 Leucine Rich Repeat DOR PF14839.6 EMC85610.1 - 0.31 11.0 4.6 0.9 9.4 4.1 1.8 1 1 0 1 1 1 0 DOR family Ribosomal_L24e PF01246.20 EMC85611.1 - 2.2e-15 56.6 0.5 2.2e-15 56.6 0.5 2.0 2 0 0 2 2 2 1 Ribosomal protein L24e PCNP PF15473.6 EMC85612.1 - 8.3e-69 231.3 12.4 9.8e-69 231.0 12.4 1.0 1 0 0 1 1 1 1 PEST, proteolytic signal-containing nuclear protein family SPATIAL PF15256.6 EMC85612.1 - 0.75 10.1 2.8 0.67 10.3 0.8 1.7 1 1 1 2 2 2 0 SPATIAL tRNA_m1G_MT PF01746.21 EMC85613.1 - 4.3e-32 111.4 0.0 8.4e-32 110.5 0.0 1.5 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase DIM1 PF02966.16 EMC85614.1 - 5.9e-55 184.7 0.1 6.8e-55 184.5 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 EMC85614.1 - 1e-05 25.4 0.0 1.4e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Arb2 PF09757.9 EMC85615.1 - 2.6e-07 30.1 0.5 3.5e-07 29.6 0.5 1.3 1 1 0 1 1 1 1 Arb2 domain DUF676 PF05057.14 EMC85615.1 - 0.0083 15.7 0.4 1.1 8.7 0.1 2.3 2 0 0 2 2 2 2 Putative serine esterase (DUF676) P63C PF10546.9 EMC85615.1 - 0.032 14.8 0.3 0.33 11.5 0.1 2.2 2 0 0 2 2 2 0 P63C domain Peptidase_C48 PF02902.19 EMC85616.1 - 1.7e-34 119.6 1.0 4.6e-34 118.1 0.5 1.8 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain TORC_M PF12885.7 EMC85616.1 - 0.059 13.3 0.9 0.56 10.1 0.2 2.3 2 0 0 2 2 2 0 Transducer of regulated CREB activity middle domain SEA PF01390.20 EMC85617.1 - 7.9e-24 83.8 6.9 1.6e-16 60.3 0.5 3.1 3 0 0 3 3 3 2 SEA domain EGF PF00008.27 EMC85617.1 - 0.00035 20.8 4.0 0.00035 20.8 4.0 2.4 2 0 0 2 2 2 2 EGF-like domain DUF4214 PF13946.6 EMC85617.1 - 0.0079 16.2 0.1 0.02 14.9 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4214) Dam PF05869.11 EMC85617.1 - 0.037 13.6 0.1 0.074 12.6 0.1 1.4 1 0 0 1 1 1 0 DNA N-6-adenine-methyltransferase (Dam) fn3 PF00041.21 EMC85618.1 - 7.7e-11 42.2 1.4 1.8e-10 41.0 1.4 1.7 1 0 0 1 1 1 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 EMC85618.1 - 0.00027 21.4 0.7 0.00077 20.0 0.7 1.8 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain DUF716 PF04819.12 EMC85619.1 - 7.4e-35 119.6 12.6 1.4e-34 118.7 12.6 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF716) TPR_1 PF00515.28 EMC85620.1 - 5.1e-39 130.5 25.6 3.3e-09 36.2 0.8 10.1 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_2 PF07719.17 EMC85620.1 - 7.6e-33 110.0 26.8 1.5e-06 27.9 0.2 10.6 11 0 0 11 11 10 7 Tetratricopeptide repeat TPR_8 PF13181.6 EMC85620.1 - 8.2e-29 97.4 20.0 0.00016 21.6 0.0 9.9 10 0 0 10 10 9 6 Tetratricopeptide repeat TPR_11 PF13414.6 EMC85620.1 - 2.1e-27 94.5 15.9 1e-06 28.3 1.2 7.8 6 2 2 8 8 8 6 TPR repeat TPR_14 PF13428.6 EMC85620.1 - 3.1e-21 74.2 7.8 0.00071 20.2 0.0 8.7 5 3 5 10 10 10 5 Tetratricopeptide repeat TPR_12 PF13424.6 EMC85620.1 - 2.9e-19 69.1 11.5 7.6e-06 26.1 0.1 7.0 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 EMC85620.1 - 1.5e-17 62.6 21.9 0.0037 17.5 0.1 9.8 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_6 PF13174.6 EMC85620.1 - 1.5e-13 50.4 7.1 1.3 9.8 0.0 9.0 9 1 0 9 9 7 1 Tetratricopeptide repeat TPR_9 PF13371.6 EMC85620.1 - 1.3e-12 47.6 1.8 0.0012 19.0 0.3 6.9 3 3 1 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 EMC85620.1 - 1.4e-10 41.5 17.1 0.03 14.8 0.1 6.6 5 1 2 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 EMC85620.1 - 1.2e-08 35.4 5.1 2.1 9.0 0.0 6.9 6 2 2 8 8 8 2 Tetratricopeptide repeat DUF5569 PF17729.1 EMC85620.1 - 7.2e-08 32.6 2.7 3e-07 30.5 0.2 2.6 2 1 1 3 3 3 1 Family of unknown function (DUF5569) TPR_7 PF13176.6 EMC85620.1 - 1e-07 31.5 6.0 0.04 14.0 0.0 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat MIT PF04212.18 EMC85620.1 - 7.4e-05 22.7 12.4 0.12 12.5 1.7 5.6 4 1 0 4 4 4 2 MIT (microtubule interacting and transport) domain NRBF2_MIT PF17169.4 EMC85620.1 - 0.00069 19.8 0.7 0.0083 16.3 0.1 2.9 2 0 0 2 2 2 1 MIT domain of nuclear receptor-binding factor 2 TPR_10 PF13374.6 EMC85620.1 - 0.0021 17.9 18.8 4.8 7.2 0.0 6.7 6 1 1 7 7 6 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 EMC85620.1 - 0.0046 16.4 0.8 4.2 6.9 0.0 4.3 4 1 1 5 5 5 1 SHNi-TPR TPR_MalT PF17874.1 EMC85620.1 - 0.0093 15.4 3.1 0.082 12.3 0.1 3.2 3 2 0 3 3 3 1 MalT-like TPR region Mad3_BUB1_I PF08311.12 EMC85620.1 - 0.013 15.4 10.0 0.59 10.1 0.2 5.1 5 1 0 5 5 5 0 Mad3/BUB1 homology region 1 PPR PF01535.20 EMC85620.1 - 0.016 15.4 0.4 7.5 7.0 0.0 3.7 3 0 0 3 3 2 0 PPR repeat HrpB1_HrpK PF09613.10 EMC85620.1 - 0.027 14.1 1.4 7.1 6.3 0.1 3.5 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) RPN7 PF10602.9 EMC85620.1 - 0.03 14.0 10.7 0.033 13.9 0.4 4.0 3 2 1 4 4 4 0 26S proteasome subunit RPN7 Hypoth_Ymh PF09509.10 EMC85620.1 - 0.053 13.4 2.1 9.2 6.2 0.1 3.9 4 0 0 4 4 4 0 Protein of unknown function (Hypoth_ymh) SPO22 PF08631.10 EMC85620.1 - 1.3 8.4 6.8 23 4.4 0.2 3.7 3 0 0 3 3 3 0 Meiosis protein SPO22/ZIP4 like MAS20 PF02064.15 EMC85620.1 - 2.2 8.4 8.5 1.6 8.8 0.0 3.7 5 0 0 5 5 3 0 MAS20 protein import receptor ANAPC3 PF12895.7 EMC85620.1 - 3.7 7.8 25.1 7.3 6.9 0.3 5.8 4 2 2 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 CN_hydrolase PF00795.22 EMC85621.1 - 1.6e-66 224.4 0.0 1.7e-66 224.2 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase AIRS PF00586.24 EMC85621.1 - 0.14 12.8 0.0 0.27 11.9 0.0 1.4 1 0 0 1 1 1 0 AIR synthase related protein, N-terminal domain RabGAP-TBC PF00566.18 EMC85622.1 - 6.6e-22 78.2 1.1 1.2e-21 77.4 1.1 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Rhodanese PF00581.20 EMC85622.1 - 1.1e-07 32.4 0.0 3.8e-07 30.6 0.0 1.9 2 0 0 2 2 2 1 Rhodanese-like domain CortBP2 PF09727.9 EMC85623.1 - 1e-62 211.5 28.6 1e-62 211.5 28.6 7.2 3 2 3 6 6 6 3 Cortactin-binding protein-2 SIKE PF05769.11 EMC85623.1 - 0.00025 21.0 13.6 0.00025 21.0 13.6 7.2 1 1 5 7 7 7 3 SIKE family Occludin_ELL PF07303.13 EMC85623.1 - 0.002 18.8 11.2 0.002 18.8 11.2 8.8 3 3 4 7 7 7 3 Occludin homology domain CMS1 PF14617.6 EMC85624.1 - 5.2e-31 107.9 2.1 8.2e-31 107.2 2.1 1.3 1 1 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 EMC85624.1 - 2.5e-06 27.4 0.0 4.3e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Herpes_ori_bp PF02399.15 EMC85624.1 - 0.0046 15.1 0.2 0.005 15.0 0.2 1.0 1 0 0 1 1 1 1 Origin of replication binding protein CDC50 PF03381.15 EMC85625.1 - 6.7e-86 288.3 2.9 8.8e-86 287.9 2.9 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family F5_F8_type_C PF00754.25 EMC85626.1 - 8.6e-26 90.5 0.4 8.6e-26 90.5 0.4 1.6 2 0 0 2 2 2 1 F5/8 type C domain CUB PF00431.20 EMC85626.1 - 2.3e-24 85.8 0.0 3.9e-24 85.1 0.0 1.4 1 0 0 1 1 1 1 CUB domain LCCL PF03815.19 EMC85626.1 - 1.6e-13 50.6 0.4 3.7e-13 49.4 0.1 1.8 2 0 0 2 2 2 1 LCCL domain Syndecan PF01034.20 EMC85626.1 - 0.0056 16.6 0.0 0.014 15.3 0.0 1.6 1 0 0 1 1 1 1 Syndecan domain DUF4448 PF14610.6 EMC85626.1 - 0.059 13.1 0.1 0.098 12.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Laminin_G_2 PF02210.24 EMC85627.1 - 1.2e-111 368.4 5.6 9.6e-29 100.5 0.0 4.2 4 0 0 4 4 4 4 Laminin G domain Laminin_G_1 PF00054.23 EMC85627.1 - 3.7e-77 256.9 2.7 6.4e-25 87.9 0.0 5.4 4 2 0 4 4 4 4 Laminin G domain Laminin_G_3 PF13385.6 EMC85627.1 - 1.1e-14 54.9 1.3 0.021 15.0 0.1 4.3 4 0 0 4 4 4 4 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.27 EMC85627.1 - 3.5e-09 36.8 17.6 7e-06 26.2 6.8 2.7 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.7 EMC85627.1 - 4.6e-05 23.9 14.7 0.014 16.0 5.3 3.0 2 0 0 2 2 2 2 Human growth factor-like EGF DUF1080 PF06439.11 EMC85627.1 - 0.00083 19.5 0.1 5.1 7.2 0.0 3.6 3 0 0 3 3 3 1 Domain of Unknown Function (DUF1080) Laminin_G_2 PF02210.24 EMC85628.1 - 9.1e-24 84.4 0.1 1.3e-23 83.9 0.1 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 EMC85628.1 - 1.1e-10 41.8 0.2 4.1e-10 40.0 0.0 1.8 2 1 0 2 2 2 1 Laminin G domain Laminin_G_3 PF13385.6 EMC85628.1 - 0.046 13.9 0.2 0.13 12.4 0.1 1.8 1 1 1 2 2 2 0 Concanavalin A-like lectin/glucanases superfamily DUF2840 PF11000.8 EMC85628.1 - 0.065 13.0 0.0 1.9 8.3 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2840) 7tm_1 PF00001.21 EMC85629.1 - 2e-35 122.4 22.1 2.8e-35 121.9 22.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.6 EMC85629.1 - 5.7e-14 51.6 7.3 0.00035 20.3 0.4 4.8 1 1 5 6 6 6 6 Leucine rich repeat LRR_5 PF13306.6 EMC85629.1 - 3.1e-11 43.4 0.1 9.2e-05 22.4 0.0 2.8 3 0 0 3 3 3 2 BspA type Leucine rich repeat region (6 copies) GnHR_trans PF12369.8 EMC85629.1 - 0.01 16.6 0.5 0.02 15.7 0.5 1.6 1 0 0 1 1 1 0 Gonadotropin hormone receptor transmembrane region LRR_4 PF12799.7 EMC85629.1 - 4.8 7.7 10.2 1.1 9.8 1.0 3.6 3 2 1 4 4 4 0 Leucine Rich repeats (2 copies) TFIIA PF03153.13 EMC85630.1 - 9.4e-113 378.3 7.9 1.4e-112 377.8 7.9 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Adap_comp_sub PF00928.21 EMC85630.1 - 1.3e-58 198.5 0.7 2.1e-58 197.8 0.7 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family SUIM_assoc PF16619.5 EMC85630.1 - 0.092 12.8 0.5 0.85 9.7 0.1 2.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Gasdermin PF04598.12 EMC85631.1 - 7.3e-29 100.9 0.1 8e-29 100.8 0.1 1.0 1 0 0 1 1 1 1 Gasdermin pore forming domain MAP1B_neuraxin PF00414.17 EMC85632.1 - 2e-10 39.7 110.7 0.0016 17.9 1.9 14.3 13 0 0 13 13 13 9 Neuraxin and MAP1B repeat TMEM252 PF15664.5 EMC85633.1 - 8.5e-15 54.7 8.8 9.4e-15 54.6 8.8 1.0 1 0 0 1 1 1 1 Transmembrane protein 252 family PGM_PMM_III PF02880.16 EMC85634.1 - 5.1e-28 97.6 0.0 8.9e-28 96.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_I PF02878.16 EMC85634.1 - 7.7e-15 54.8 0.0 1.2e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 EMC85634.1 - 1e-12 48.5 0.0 2.7e-12 47.2 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II cobW PF02492.19 EMC85635.1 - 5.1e-50 169.5 0.1 7e-50 169.0 0.1 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EMC85635.1 - 1.4e-19 69.8 0.0 2.4e-19 69.0 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain GTP_EFTU PF00009.27 EMC85635.1 - 3.1e-06 26.8 0.8 0.00066 19.3 0.2 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EMC85635.1 - 4.9e-06 26.6 0.4 0.068 13.1 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EMC85635.1 - 0.0072 16.4 0.2 0.11 12.6 0.0 2.8 1 1 0 2 2 2 1 50S ribosome-binding GTPase TsaE PF02367.17 EMC85635.1 - 0.011 15.7 0.1 0.17 11.9 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_23 PF13476.6 EMC85635.1 - 0.017 15.7 0.1 0.017 15.7 0.1 2.0 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EMC85635.1 - 0.018 15.4 0.0 0.039 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EMC85635.1 - 0.023 15.0 0.1 0.17 12.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EMC85635.1 - 0.038 14.5 0.2 0.077 13.5 0.2 1.8 1 1 0 1 1 1 0 ABC transporter Zeta_toxin PF06414.12 EMC85635.1 - 0.046 13.0 0.1 0.11 11.7 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin AAA_29 PF13555.6 EMC85635.1 - 0.069 12.9 0.1 0.15 11.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.6 EMC85635.1 - 0.071 13.1 0.1 0.31 11.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EMC85635.1 - 0.077 12.7 0.3 0.39 10.4 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EMC85635.1 - 0.078 13.5 0.9 0.18 12.4 0.2 2.0 2 1 0 2 2 2 0 AAA domain Spc24 PF08286.11 EMC85635.1 - 0.11 12.7 2.4 0.081 13.2 0.7 1.7 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DHR-2 PF06920.13 EMC85636.1 - 1e-210 700.9 2.5 1.9e-210 700.0 2.5 1.4 1 0 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 EMC85636.1 - 5.3e-51 173.2 0.1 1.2e-50 172.0 0.1 1.7 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.8 EMC85636.1 - 3.1e-30 104.9 0.1 1.4e-29 102.8 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3398) DOCK_N PF16172.5 EMC85636.1 - 0.027 13.4 0.1 0.1 11.5 0.0 2.0 2 0 0 2 2 2 0 DOCK N-terminus GPR15L PF15854.5 EMC85636.1 - 0.06 13.6 0.2 0.18 12.0 0.2 1.8 1 0 0 1 1 1 0 G-protein coupled receptor ligand 15 Dmrt1 PF12374.8 EMC85637.1 - 1.5e-32 111.8 4.8 1.5e-32 111.8 4.8 1.9 2 1 0 2 2 2 1 Double-sex mab3 related transcription factor 1 Ustilago_mating PF05722.12 EMC85637.1 - 0.0077 15.8 0.9 0.0098 15.5 0.9 1.1 1 0 0 1 1 1 1 Ustilago B locus mating-type protein DMA PF03474.14 EMC85638.1 - 8.6e-17 60.4 0.1 1.3e-16 59.8 0.1 1.3 1 0 0 1 1 1 1 DMRTA motif DM PF00751.18 EMC85639.1 - 5.4e-20 71.0 13.7 1.3e-19 69.8 13.7 1.7 1 0 0 1 1 1 1 DM DNA binding domain DUF4490 PF14892.6 EMC85639.1 - 0.024 14.7 0.3 0.068 13.2 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4490) Ion_trans PF00520.31 EMC85640.1 - 1.8e-37 128.9 1.3 2.2e-37 128.6 1.3 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 EMC85640.1 - 1.7e-21 76.3 0.0 4.7e-21 75.0 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 EMC85640.1 - 5.2e-13 48.8 3.6 5.2e-13 48.8 3.6 1.9 2 0 0 2 2 2 1 Ion channel PKD_channel PF08016.12 EMC85640.1 - 3.9e-05 22.5 2.0 6.3e-05 21.8 1.8 1.5 1 1 0 1 1 1 1 Polycystin cation channel Myb_CC_LHEQLE PF14379.6 EMC85640.1 - 0.031 14.0 5.2 0.057 13.1 5.2 1.4 1 0 0 1 1 1 0 MYB-CC type transfactor, LHEQLE motif DctQ PF04290.12 EMC85640.1 - 1.9 8.4 8.4 0.32 10.9 1.7 2.6 2 1 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component PsbI PF02532.14 EMC85641.1 - 4.7 7.2 9.5 1.5 8.9 5.0 2.2 2 0 0 2 2 2 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) CARM1 PF11531.8 EMC85642.1 - 3.8e-19 68.9 1.4 7.1e-19 68.1 1.4 1.5 1 0 0 1 1 1 1 Coactivator-associated arginine methyltransferase 1 N terminal PrmA PF06325.13 EMC85642.1 - 1.3e-09 37.8 0.0 2.2e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EMC85642.1 - 1.4e-08 35.3 0.0 3.4e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC85642.1 - 1.2e-06 29.1 0.0 3.4e-06 27.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EMC85642.1 - 1.3e-06 28.0 0.0 1.1e-05 25.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_9 PF08003.11 EMC85642.1 - 3.4e-06 26.2 0.0 5.1e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_18 PF12847.7 EMC85642.1 - 8e-06 25.9 0.0 1.5e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC85642.1 - 2.6e-05 24.0 0.0 6.4e-05 22.8 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC85642.1 - 3.3e-05 23.8 0.1 0.00071 19.4 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.16 EMC85642.1 - 0.00034 20.5 0.0 0.00059 19.7 0.0 1.5 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Met_10 PF02475.16 EMC85642.1 - 0.00039 20.2 0.1 0.00062 19.6 0.1 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 EMC85642.1 - 0.00043 20.0 0.0 0.00077 19.1 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 CMAS PF02353.20 EMC85642.1 - 0.00062 19.1 0.0 0.00092 18.6 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 EMC85642.1 - 0.0016 19.1 0.0 0.0065 17.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain PRMT5_C PF17286.2 EMC85642.1 - 0.0041 17.0 0.4 0.0073 16.2 0.4 1.4 1 0 0 1 1 1 1 PRMT5 oligomerisation domain TehB PF03848.14 EMC85642.1 - 0.038 13.4 0.0 0.073 12.5 0.0 1.5 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_32 PF13679.6 EMC85642.1 - 0.055 13.5 0.0 0.095 12.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.6 EMC85642.1 - 0.16 13.0 0.0 0.39 11.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain RFX_DNA_binding PF02257.15 EMC85643.1 - 8.2e-34 116.1 0.1 2.9e-33 114.3 0.1 2.0 1 0 0 1 1 1 1 RFX DNA-binding domain HisKA PF00512.25 EMC85643.1 - 0.014 15.5 0.3 0.033 14.2 0.3 1.7 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain Pox_D5 PF03288.16 EMC85643.1 - 0.049 14.1 0.0 0.15 12.5 0.0 1.8 1 0 0 1 1 1 0 Poxvirus D5 protein-like DUF2258 PF10015.9 EMC85643.1 - 0.11 12.7 0.2 0.5 10.5 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2258) zf-C2H2 PF00096.26 EMC85644.1 - 5e-17 61.3 24.9 0.0009 19.6 0.8 5.8 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC85644.1 - 2e-09 37.4 23.0 5.2e-05 23.5 0.8 5.1 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC85644.1 - 2e-06 28.1 24.6 0.007 17.1 0.2 5.8 5 0 0 5 5 5 3 C2H2-type zinc finger FOXP-CC PF16159.5 EMC85644.1 - 3e-06 27.8 15.1 0.17 12.5 0.1 5.3 1 1 3 5 5 5 3 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 EMC85644.1 - 0.029 14.7 12.0 0.069 13.5 1.1 4.5 3 1 1 4 4 4 0 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.5 EMC85644.1 - 0.093 12.9 9.9 11 6.2 0.4 4.4 1 1 2 4 4 4 0 Aberrant zinc-finger EpoR_lig-bind PF09067.10 EMC85644.1 - 0.13 12.5 0.2 0.27 11.5 0.2 1.5 1 0 0 1 1 1 0 Erythropoietin receptor, ligand binding PcF PF09461.10 EMC85644.1 - 2 8.9 6.4 21 5.6 0.2 4.2 4 0 0 4 4 4 0 Phytotoxin PcF protein zf-C2H2_jaz PF12171.8 EMC85644.1 - 6 7.3 6.9 45 4.5 0.9 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC85644.1 - 6.4 7.3 6.7 12 6.5 0.1 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 EMC85644.1 - 8.9 6.2 12.3 30 4.5 0.1 4.4 4 0 0 4 4 4 0 C2H2-type zinc-finger domain SDF PF00375.18 EMC85645.1 - 1.8e-131 438.8 26.2 2e-131 438.6 26.2 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family C2 PF00168.30 EMC85646.1 - 8.7e-05 22.8 0.0 0.00017 21.8 0.0 1.5 1 0 0 1 1 1 1 C2 domain YbjQ_1 PF01906.17 EMC85646.1 - 0.00081 20.0 5.3 0.026 15.2 0.0 4.2 4 1 0 4 4 4 1 Putative heavy-metal-binding Glyco_transf_29 PF00777.18 EMC85647.1 - 3.9e-78 262.6 0.0 4.6e-78 262.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Sulfotransfer_1 PF00685.27 EMC85648.1 - 1.2e-67 228.2 4.5 3.6e-65 220.1 4.5 2.1 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC85648.1 - 0.00021 21.7 0.0 0.0018 18.7 0.0 2.1 2 0 0 2 2 2 1 Sulfotransferase family zf-C2H2_3 PF13878.6 EMC85648.1 - 0.12 12.3 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO CTP_transf_3 PF02348.19 EMC85649.1 - 1.7e-35 123.0 0.0 2.4e-35 122.5 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase Hydrolase_3 PF08282.12 EMC85649.1 - 4e-05 23.5 0.2 0.00067 19.5 0.0 2.7 2 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase ABC_membrane PF00664.23 EMC85650.1 - 5.8e-65 219.7 26.1 3.9e-33 115.3 3.4 2.6 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EMC85650.1 - 3.9e-52 176.4 0.2 1.3e-24 87.3 0.0 3.5 4 0 0 4 4 3 2 ABC transporter SMC_N PF02463.19 EMC85650.1 - 5.5e-07 29.2 7.1 0.018 14.5 0.1 4.3 3 2 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EMC85650.1 - 8.5e-06 25.8 2.3 0.95 9.2 0.0 3.7 3 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EMC85650.1 - 2.6e-05 24.2 0.2 0.025 14.5 0.1 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EMC85650.1 - 0.00015 21.4 1.5 0.078 12.7 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EMC85650.1 - 0.0011 19.0 0.1 1.6 8.9 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase IstB_IS21 PF01695.17 EMC85650.1 - 0.003 17.3 0.8 5.3 6.7 0.0 3.6 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_22 PF13401.6 EMC85650.1 - 0.0041 17.4 0.1 2.1 8.6 0.0 2.9 3 0 0 3 3 2 1 AAA domain Zeta_toxin PF06414.12 EMC85650.1 - 0.012 14.9 0.0 0.2 10.9 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_7 PF12775.7 EMC85650.1 - 0.013 15.1 0.0 3.4 7.1 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_16 PF13191.6 EMC85650.1 - 0.021 15.2 0.1 0.62 10.4 0.0 2.8 2 1 0 2 2 2 0 AAA ATPase domain AAA_25 PF13481.6 EMC85650.1 - 0.03 13.9 0.0 0.93 9.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 EMC85650.1 - 0.042 13.0 0.0 4.7 6.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) CENP-B_dimeris PF09026.10 EMC85650.1 - 0.063 13.7 0.2 0.15 12.5 0.2 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain AAA_24 PF13479.6 EMC85650.1 - 0.066 12.9 0.1 1.3 8.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EMC85650.1 - 0.071 12.8 0.0 2.6 7.7 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain ABC_ATPase PF09818.9 EMC85650.1 - 0.072 11.9 1.1 8 5.1 0.0 3.2 3 1 0 3 3 3 0 Predicted ATPase of the ABC class AAA_23 PF13476.6 EMC85650.1 - 0.09 13.3 9.7 15 6.0 0.0 3.2 2 1 0 2 2 2 0 AAA domain ATPase PF06745.13 EMC85650.1 - 0.28 10.5 1.2 9.9 5.4 0.1 2.4 2 0 0 2 2 2 0 KaiC AAA_15 PF13175.6 EMC85650.1 - 0.31 10.7 2.6 3.3 7.3 0.0 2.8 3 0 0 3 3 3 0 AAA ATPase domain Dynamin_N PF00350.23 EMC85650.1 - 1 9.4 4.8 1.8 8.6 0.1 3.2 3 0 0 3 3 3 0 Dynamin family IRK_C PF17655.1 EMC85651.1 - 1.8e-71 239.3 0.0 2.5e-71 238.8 0.0 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 EMC85651.1 - 6.8e-59 197.7 4.8 9.9e-59 197.2 4.8 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain EI24 PF07264.11 EMC85651.1 - 0.11 12.7 3.5 0.18 12.0 3.5 1.3 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Ldh_1_N PF00056.23 EMC85652.1 - 2.7e-49 166.9 0.8 3.8e-49 166.4 0.8 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EMC85652.1 - 4.2e-22 78.8 0.0 7e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.16 EMC85652.1 - 0.0005 19.7 0.4 0.0015 18.1 0.1 1.8 1 1 1 2 2 2 1 Family 4 glycosyl hydrolase Ldh_1_N PF00056.23 EMC85653.1 - 3.8e-49 166.4 1.0 5.4e-49 165.9 1.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EMC85653.1 - 9.1e-21 74.5 0.0 1.9e-20 73.5 0.0 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.16 EMC85653.1 - 0.00072 19.2 0.4 0.0021 17.6 0.1 1.9 1 1 1 2 2 2 1 Family 4 glycosyl hydrolase Glycogen_syn PF05693.13 EMC85654.1 - 0 1187.5 0.0 0 1187.2 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glyco_transf_4 PF13439.6 EMC85654.1 - 2.2e-05 24.5 0.1 4.6e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 EMC85654.1 - 2.2e-05 24.1 0.0 0.00033 20.3 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EMC85654.1 - 3.5e-05 24.2 0.0 0.0058 17.1 0.0 2.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 Spexin PF15171.6 EMC85655.1 - 5.8e-43 145.0 2.2 5.8e-43 145.0 2.2 1.4 2 0 0 2 2 2 1 Neuropeptide secretory protein family, NPQ, spexin MRVI1 PF05781.12 EMC85657.1 - 9.8e-147 489.9 5.4 1.2e-146 489.6 5.4 1.0 1 0 0 1 1 1 1 MRVI1 protein DUF919 PF06034.11 EMC85657.1 - 0.51 10.2 4.5 0.33 10.8 1.9 2.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) Fib_alpha PF08702.10 EMC85657.1 - 0.74 10.0 5.3 1.4 9.1 5.3 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Complex1_LYR PF05347.15 EMC85658.1 - 1.5e-15 57.0 0.4 2.4e-15 56.3 0.4 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EMC85658.1 - 6.1e-08 33.3 0.6 8.5e-08 32.8 0.6 1.3 1 1 0 1 1 1 1 Complex1_LYR-like Ras PF00071.22 EMC85659.1 - 1.3e-58 197.2 0.0 1.5e-58 196.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC85659.1 - 6.5e-22 78.0 0.0 1.3e-21 77.1 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC85659.1 - 9.5e-10 38.2 0.0 1.2e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC85659.1 - 2.4e-07 30.5 0.5 2.3e-06 27.3 0.1 2.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EMC85659.1 - 2.5e-06 27.5 0.0 0.017 15.1 0.0 2.5 2 1 1 3 3 3 2 RsgA GTPase MMR_HSR1 PF01926.23 EMC85659.1 - 1.2e-05 25.4 0.1 3e-05 24.1 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase MeaB PF03308.16 EMC85659.1 - 0.0015 17.6 0.2 0.022 13.7 0.1 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB G-alpha PF00503.20 EMC85659.1 - 0.0023 17.2 0.3 0.091 11.9 0.3 2.1 1 1 1 2 2 2 2 G-protein alpha subunit FeoB_N PF02421.18 EMC85659.1 - 0.0024 17.4 0.0 0.022 14.3 0.0 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B ATP_bind_1 PF03029.17 EMC85659.1 - 0.019 14.8 0.7 0.4 10.4 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Septin PF00735.18 EMC85659.1 - 0.024 13.9 0.3 0.054 12.8 0.0 1.9 2 1 0 2 2 2 0 Septin AAA_25 PF13481.6 EMC85659.1 - 0.15 11.6 0.0 0.38 10.3 0.0 1.7 2 1 1 3 3 3 0 AAA domain RA PF00788.23 EMC85660.1 - 4e-06 27.4 0.0 1e-05 26.0 0.0 1.8 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain DUF5344 PF17279.2 EMC85660.1 - 0.025 15.1 6.2 0.025 15.1 6.2 3.4 1 1 4 5 5 5 0 Family of unknown function (DUF5344) Tropomyosin PF00261.20 EMC85660.1 - 0.045 13.1 41.4 0.057 12.8 26.9 2.2 1 1 1 2 2 2 0 Tropomyosin Fib_alpha PF08702.10 EMC85660.1 - 0.054 13.7 32.7 0.33 11.1 4.2 4.1 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family YscO PF07321.12 EMC85660.1 - 5.4 7.0 42.4 4.2 7.3 5.9 2.9 1 1 2 3 3 3 0 Type III secretion protein YscO DUF3584 PF12128.8 EMC85660.1 - 6.5 4.1 34.3 9.7 3.5 34.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) HLH PF00010.26 EMC85661.1 - 1.3e-13 50.6 1.8 2.1e-13 50.0 1.8 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 EMC85661.1 - 3.1e-10 40.1 1.5 5.2e-10 39.4 0.7 1.9 2 0 0 2 2 2 1 Hairy Orange CD20 PF04103.15 EMC85662.1 - 1.1e-23 84.0 15.0 1.1e-23 84.0 15.0 1.5 2 0 0 2 2 2 1 CD20-like family DUF5336 PF17270.2 EMC85662.1 - 0.0043 16.7 1.7 0.013 15.2 0.4 2.1 2 0 0 2 2 2 1 Family of unknown function (DUF5336) DUF1686 PF07937.11 EMC85662.1 - 0.0094 15.8 0.2 0.0094 15.8 0.2 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1686) Bac_export_2 PF01312.19 EMC85662.1 - 0.03 13.6 0.5 0.058 12.6 0.5 1.4 1 1 0 1 1 1 0 FlhB HrpN YscU SpaS Family TcpE PF12648.7 EMC85662.1 - 0.034 14.7 2.8 0.034 14.7 2.8 2.1 2 1 0 2 2 2 0 TcpE family DUF4579 PF15158.6 EMC85662.1 - 0.047 13.5 0.2 0.047 13.5 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4579) DUF2371 PF10177.9 EMC85662.1 - 0.69 10.1 4.2 16 5.7 0.1 2.9 1 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) DEC-1_N PF04625.13 EMC85663.1 - 0.078 12.0 0.1 0.095 11.7 0.1 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region DUF5554 PF17709.1 EMC85664.1 - 0.051 13.7 0.1 0.085 13.0 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5554) Sec2p PF06428.11 EMC85665.1 - 0.0014 18.5 6.4 0.0018 18.2 6.4 1.1 1 0 0 1 1 1 1 GDP/GTP exchange factor Sec2p Tropomyosin_1 PF12718.7 EMC85665.1 - 0.0042 17.3 1.8 0.0048 17.1 1.8 1.1 1 0 0 1 1 1 1 Tropomyosin like TEX13 PF15186.6 EMC85665.1 - 0.0042 16.8 1.5 0.0045 16.7 1.5 1.0 1 0 0 1 1 1 1 Testis-expressed sequence 13 protein family Spc7 PF08317.11 EMC85665.1 - 0.0048 15.8 3.0 0.0054 15.7 3.0 1.0 1 0 0 1 1 1 1 Spc7 kinetochore protein Mating_N PF12731.7 EMC85665.1 - 0.011 15.7 0.1 0.015 15.3 0.1 1.2 1 0 0 1 1 1 0 Mating-type protein beta 1 Glutaredoxin2_C PF04399.13 EMC85665.1 - 0.018 14.9 0.9 0.11 12.3 0.8 1.8 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain SOG2 PF10428.9 EMC85665.1 - 0.02 14.1 0.8 0.022 14.0 0.8 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein Ran-binding PF05508.11 EMC85665.1 - 0.05 12.6 0.3 0.051 12.6 0.3 1.1 1 0 0 1 1 1 0 RanGTP-binding protein COG2 PF06148.11 EMC85665.1 - 0.059 13.5 2.0 0.075 13.1 2.0 1.1 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 GP41 PF00517.17 EMC85665.1 - 0.076 12.9 0.4 0.086 12.7 0.4 1.1 1 0 0 1 1 1 0 Retroviral envelope protein Retrotrans_gag PF03732.17 EMC85665.1 - 0.078 13.3 0.7 0.096 13.0 0.7 1.1 1 0 0 1 1 1 0 Retrotransposon gag protein PRCC PF10253.9 EMC85665.1 - 0.085 13.6 2.4 0.094 13.5 2.4 1.0 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Exonuc_VII_L PF02601.15 EMC85665.1 - 0.11 12.1 1.0 0.11 12.0 1.0 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Spc24 PF08286.11 EMC85665.1 - 0.12 12.7 2.0 0.14 12.4 2.0 1.2 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 EMP24_GP25L PF01105.24 EMC85665.1 - 0.16 11.9 0.9 0.17 11.8 0.9 1.0 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DASH_Hsk3 PF08227.11 EMC85665.1 - 0.17 12.3 4.4 8.6 6.8 4.4 2.8 1 1 1 2 2 2 0 DASH complex subunit Hsk3 like Csm1_N PF18504.1 EMC85665.1 - 0.3 11.4 7.2 0.68 10.3 3.1 1.8 1 1 1 2 2 2 0 Csm1 N-terminal domain Atg14 PF10186.9 EMC85665.1 - 0.4 9.7 4.7 0.47 9.5 4.7 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 IATP PF04568.12 EMC85665.1 - 0.77 10.2 4.1 1.3 9.5 4.1 1.4 1 1 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP RYDR_ITPR PF01365.21 EMC85666.1 - 5.1e-12 45.6 0.1 9e-12 44.8 0.1 1.4 1 0 0 1 1 1 1 RIH domain He_PIG PF05345.12 EMC85667.1 - 0.00031 20.9 0.1 0.011 15.9 0.0 3.2 2 0 0 2 2 2 1 Putative Ig domain a_DG1_N2 PF18424.1 EMC85667.1 - 0.00034 20.7 0.0 0.00063 19.8 0.0 1.4 1 0 0 1 1 1 1 Alpha-Dystroglycan N-terminal domain 2 DUF2151 PF10221.9 EMC85668.1 - 6.1e-303 1006.7 4.5 7e-303 1006.5 4.5 1.0 1 0 0 1 1 1 1 Cell cycle and development regulator Plk4_PB2 PF18409.1 EMC85668.1 - 0.065 13.9 0.1 0.63 10.8 0.1 2.6 2 0 0 2 2 2 0 Polo-like Kinase 4 Polo Box 2 SIKE PF05769.11 EMC85669.1 - 1.2e-73 246.8 26.6 1.5e-73 246.6 26.6 1.0 1 0 0 1 1 1 1 SIKE family Tho2 PF11262.8 EMC85669.1 - 0.0017 17.6 6.2 0.0017 17.6 6.2 2.0 1 1 1 2 2 2 1 Transcription factor/nuclear export subunit protein 2 TPR_8 PF13181.6 EMC85669.1 - 0.22 11.8 1.1 10 6.6 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat CHD5 PF04420.14 EMC85669.1 - 0.39 10.6 4.6 1.3 8.8 4.6 1.9 1 1 0 1 1 1 0 CHD5-like protein DUF3829 PF12889.7 EMC85669.1 - 0.67 9.4 12.6 0.067 12.7 1.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3829) CotJB PF12652.7 EMC85669.1 - 1.3 9.3 4.1 4.3 7.6 0.1 2.7 3 0 0 3 3 3 0 CotJB protein NYD-SP28_assoc PF14775.6 EMC85669.1 - 1.5 8.9 14.9 0.99 9.6 1.9 3.7 3 1 0 3 3 3 0 Sperm tail C-terminal domain BST2 PF16716.5 EMC85669.1 - 1.9 9.1 20.5 3 8.5 2.4 3.7 3 1 1 4 4 4 0 Bone marrow stromal antigen 2 bZIP_1 PF00170.21 EMC85669.1 - 2.5 8.3 22.2 2 8.6 0.8 4.4 2 2 2 4 4 4 0 bZIP transcription factor Exonuc_VII_L PF02601.15 EMC85669.1 - 3.2 7.2 13.6 4.6 6.7 13.6 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit FUSC PF04632.12 EMC85669.1 - 3.3 6.1 11.5 3.8 5.9 11.1 1.3 1 1 0 1 1 1 0 Fusaric acid resistance protein family DASH_Dam1 PF08653.10 EMC85669.1 - 4 7.3 5.0 1.5 8.7 0.2 2.6 3 0 0 3 3 3 0 DASH complex subunit Dam1 Sec20 PF03908.13 EMC85669.1 - 7.2 6.6 13.9 8.6 6.3 0.3 3.4 1 1 2 3 3 3 0 Sec20 Wtap PF17098.5 EMC85669.1 - 7.4 6.5 22.0 3.5 7.5 11.9 3.4 1 1 0 2 2 2 0 WTAP/Mum2p family Atg14 PF10186.9 EMC85669.1 - 9.3 5.2 20.6 23 3.9 20.6 1.6 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4203 PF13886.6 EMC85670.1 - 1.7e-37 129.1 35.9 2.3e-37 128.6 35.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) Med21 PF11221.8 EMC85671.1 - 2.5e-19 70.0 0.3 3.8e-19 69.4 0.3 1.3 1 0 0 1 1 1 1 Subunit 21 of Mediator complex TelA PF05816.11 EMC85671.1 - 0.0093 15.1 0.1 0.011 14.8 0.1 1.1 1 0 0 1 1 1 1 Toxic anion resistance protein (TelA) Pkinase PF00069.25 EMC85672.1 - 3.7e-61 206.8 0.1 1.6e-60 204.8 0.1 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC85672.1 - 1e-27 97.1 1.8 4e-19 68.9 0.1 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.24 EMC85672.1 - 9e-08 32.7 1.9 1.3e-07 32.2 0.9 1.8 2 0 0 2 2 2 1 Protein kinase C terminal domain Kdo PF06293.14 EMC85672.1 - 0.00066 19.1 0.2 0.0013 18.2 0.2 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EMC85672.1 - 0.0011 18.0 0.1 0.0016 17.5 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EMC85672.1 - 0.0015 17.9 0.3 0.076 12.3 0.0 2.5 2 1 0 2 2 2 1 Kinase-like APH PF01636.23 EMC85672.1 - 0.0016 18.4 1.0 0.23 11.4 0.3 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family PAS_11 PF14598.6 EMC85673.1 - 1.3e-27 96.2 0.2 4.9e-24 84.6 0.1 2.4 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.12 EMC85673.1 - 1.5e-23 82.9 0.0 9.7e-16 57.8 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 EMC85673.1 - 4.8e-23 81.3 0.0 2.9e-10 40.2 0.0 2.7 2 1 0 2 2 2 2 PAS fold HLH PF00010.26 EMC85673.1 - 9.4e-16 57.5 1.6 2.6e-15 56.1 1.6 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.7 EMC85673.1 - 9.7e-14 51.5 0.0 6e-07 29.7 0.0 2.8 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 EMC85673.1 - 6e-07 29.7 0.0 0.0029 17.8 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_2 PF08446.11 EMC85673.1 - 0.022 15.5 0.0 0.088 13.5 0.0 2.0 2 0 0 2 2 2 0 PAS fold IL3 PF02059.15 EMC85673.1 - 0.41 10.7 3.1 0.79 9.8 0.6 2.8 3 0 0 3 3 3 0 Interleukin-3 SAM_1 PF00536.30 EMC85674.1 - 3.2e-32 110.8 13.0 2.6e-16 59.8 0.5 4.4 4 1 0 4 4 4 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC85674.1 - 4.7e-29 100.3 9.0 2.4e-14 53.2 0.0 4.1 4 0 0 4 4 4 3 SAM domain (Sterile alpha motif) DUF16 PF01519.16 EMC85674.1 - 0.00025 21.5 13.0 0.00078 19.9 1.9 3.1 2 0 0 2 2 2 2 Protein of unknown function DUF16 SAM_PNT PF02198.16 EMC85674.1 - 0.016 15.2 5.7 0.72 9.9 0.9 3.5 3 1 0 3 3 3 0 Sterile alpha motif (SAM)/Pointed domain DUF4407 PF14362.6 EMC85674.1 - 2.1 7.6 15.6 3.7 6.8 9.5 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) DUF1779 PF08680.10 EMC85674.1 - 4.7 7.3 9.9 0.35 11.0 4.6 2.0 2 1 0 2 2 2 0 TATA-box binding Rab15_effector PF15208.6 EMC85675.1 - 2.7e-101 337.9 0.3 3e-101 337.7 0.3 1.0 1 0 0 1 1 1 1 Rab15 effector NAD_binding_1 PF00175.21 EMC85676.1 - 1.2e-36 125.7 0.0 1.8e-36 125.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EMC85676.1 - 7.4e-36 122.5 0.0 1.1e-35 121.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EMC85676.1 - 9.5e-06 25.8 0.0 0.00023 21.3 0.0 2.1 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Gb3_synth PF04572.12 EMC85677.1 - 3.7e-42 143.6 0.4 5.8e-42 142.9 0.4 1.3 1 0 0 1 1 1 1 Alpha 1,4-glycosyltransferase conserved region Gly_transf_sug PF04488.15 EMC85677.1 - 2.2e-21 76.3 0.0 6.8e-21 74.7 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif Thaumatin PF00314.17 EMC85677.1 - 0.055 13.1 0.0 0.092 12.4 0.0 1.4 1 0 0 1 1 1 0 Thaumatin family TcdA_TcdB PF12919.7 EMC85677.1 - 0.061 12.6 0.0 0.09 12.1 0.0 1.2 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain Gb3_synth PF04572.12 EMC85678.1 - 2.2e-44 150.8 0.3 3.4e-44 150.2 0.3 1.3 1 0 0 1 1 1 1 Alpha 1,4-glycosyltransferase conserved region Gly_transf_sug PF04488.15 EMC85678.1 - 1e-21 77.4 0.0 2.3e-21 76.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 EMC85678.1 - 0.001 18.5 0.0 0.0016 17.8 0.0 1.2 1 0 0 1 1 1 1 TcdA/TcdB catalytic glycosyltransferase domain Caps_synth PF05704.12 EMC85678.1 - 0.013 14.9 0.1 0.041 13.2 0.0 1.9 3 0 0 3 3 3 0 Capsular polysaccharide synthesis protein Gb3_synth PF04572.12 EMC85679.1 - 5.2e-45 152.8 0.6 7e-45 152.4 0.6 1.2 1 0 0 1 1 1 1 Alpha 1,4-glycosyltransferase conserved region Gly_transf_sug PF04488.15 EMC85679.1 - 1.2e-14 54.7 0.1 4.6e-14 52.8 0.0 2.0 3 0 0 3 3 3 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 EMC85679.1 - 0.026 13.9 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain Gb3_synth PF04572.12 EMC85680.1 - 3.3e-48 163.1 1.8 3.9e-48 162.9 1.8 1.1 1 0 0 1 1 1 1 Alpha 1,4-glycosyltransferase conserved region Gly_transf_sug PF04488.15 EMC85680.1 - 3.3e-07 30.9 0.6 3.5e-06 27.6 0.1 2.4 3 0 0 3 3 3 1 Glycosyltransferase sugar-binding region containing DXD motif HEPN-like_int PF18867.1 EMC85680.1 - 0.029 14.3 0.0 0.049 13.5 0.0 1.4 1 0 0 1 1 1 0 HEPN-like integron domain Gb3_synth PF04572.12 EMC85683.1 - 1.1e-43 148.5 0.2 1.6e-43 148.0 0.2 1.3 1 0 0 1 1 1 1 Alpha 1,4-glycosyltransferase conserved region Gly_transf_sug PF04488.15 EMC85683.1 - 2.5e-20 72.9 0.0 7.1e-20 71.5 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 EMC85683.1 - 0.049 12.9 0.0 0.088 12.1 0.0 1.3 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain Gb3_synth PF04572.12 EMC85684.1 - 9.5e-48 161.7 1.8 1.5e-47 161.0 1.8 1.3 1 0 0 1 1 1 1 Alpha 1,4-glycosyltransferase conserved region Gly_transf_sug PF04488.15 EMC85684.1 - 9.2e-23 80.7 0.0 4.6e-22 78.5 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif HEPN-like_int PF18867.1 EMC85684.1 - 0.0058 16.5 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 HEPN-like integron domain TcdA_TcdB PF12919.7 EMC85684.1 - 0.037 13.3 0.0 0.052 12.8 0.0 1.2 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain ArfGap PF01412.18 EMC85685.1 - 3.4e-28 98.1 7.6 8.8e-28 96.7 1.6 2.7 2 0 0 2 2 2 2 Putative GTPase activating protein for Arf FCH PF00611.23 EMC85686.1 - 9.7e-16 57.8 0.3 9.7e-16 57.8 0.3 3.1 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 EMC85686.1 - 1.9e-15 56.2 0.1 4.1e-15 55.1 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC85686.1 - 4.4e-15 55.3 0.2 4.4e-15 55.3 0.2 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EMC85686.1 - 2.8e-08 33.3 0.0 6.5e-08 32.1 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain NPF PF16601.5 EMC85686.1 - 1.1e-05 26.0 8.3 1.1e-05 26.0 8.3 1.8 2 0 0 2 2 2 1 Rabosyn-5 repeating NPF sequence-motif SH3_10 PF17902.1 EMC85686.1 - 0.13 12.3 0.0 0.57 10.3 0.0 2.1 2 0 0 2 2 2 0 SH3 domain DegS PF05384.11 EMC85686.1 - 7.9 5.9 18.6 0.083 12.4 8.0 2.8 3 1 0 3 3 3 0 Sensor protein DegS TTL PF03133.15 EMC85687.1 - 1.1e-101 339.9 0.6 1.5e-101 339.5 0.6 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EMC85687.1 - 4.2e-07 29.5 0.2 0.00028 20.2 0.0 2.3 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 EMC85687.1 - 0.00015 21.1 0.0 0.00088 18.6 0.0 2.0 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp bcl-2I13 PF12201.8 EMC85688.1 - 8.7e-08 32.2 0.0 9.7e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Bcl2-interacting killer, BH3-domain containing Bclx_interact PF08945.10 EMC85688.1 - 0.069 12.9 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 Bcl-x interacting, BH3 domain Acyl_transf_1 PF00698.21 EMC85689.1 - 4.5e-12 46.1 0.1 7.3e-12 45.4 0.1 1.2 1 0 0 1 1 1 1 Acyl transferase domain TspO_MBR PF03073.15 EMC85690.1 - 2.9e-49 166.6 12.7 3.4e-49 166.4 12.7 1.0 1 0 0 1 1 1 1 TspO/MBR family DUF1358 PF07096.11 EMC85690.1 - 9.7 6.2 8.5 0.94 9.5 1.3 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1358) TTL PF03133.15 EMC85691.1 - 3.2e-71 239.9 0.1 4.4e-71 239.4 0.1 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family FXa_inhibition PF14670.6 EMC85692.1 - 2.7e-64 213.1 177.9 1.3e-12 47.8 9.1 12.2 12 1 0 12 12 12 9 Coagulation Factor Xa inhibitory site cEGF PF12662.7 EMC85692.1 - 3.2e-45 151.7 85.8 2e-09 37.2 1.1 12.3 11 1 0 11 11 11 9 Complement Clr-like EGF-like Ephrin_rec_like PF07699.13 EMC85692.1 - 1.3e-35 120.9 34.9 4.1e-15 55.3 8.4 6.6 7 1 1 8 8 8 3 Putative ephrin-receptor like EGF_CA PF07645.15 EMC85692.1 - 9.1e-30 102.6 170.9 2.6e-09 37.1 8.5 11.9 12 0 0 12 12 12 7 Calcium-binding EGF domain EGF_3 PF12947.7 EMC85692.1 - 2.5e-22 78.8 139.7 2.6e-10 40.3 9.5 11.4 10 1 0 10 10 10 8 EGF domain CUB PF00431.20 EMC85692.1 - 4.1e-17 62.5 0.0 4.1e-17 62.5 0.0 2.4 3 0 0 3 3 3 1 CUB domain EGF PF00008.27 EMC85692.1 - 2.4e-16 59.7 136.0 8.7e-06 25.9 5.4 12.1 10 1 2 12 12 12 8 EGF-like domain hEGF PF12661.7 EMC85692.1 - 8.2e-05 23.1 114.8 0.00015 22.3 1.9 12.7 11 1 0 11 11 11 6 Human growth factor-like EGF DUF5398 PF17376.2 EMC85692.1 - 0.15 12.7 0.5 0.38 11.4 0.5 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5398) DUF4375 PF14300.6 EMC85692.1 - 0.15 12.3 0.2 19 5.5 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4375) Metallophos PF00149.28 EMC85693.1 - 2.1e-11 44.7 0.6 3.2e-11 44.1 0.6 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EMC85693.1 - 2.1e-07 31.3 0.0 4.9e-06 26.8 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Sulfotransfer_1 PF00685.27 EMC85694.1 - 9.9e-50 169.5 0.2 1.4e-49 169.0 0.2 1.3 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC85694.1 - 7.7e-09 36.2 0.1 1.1e-08 35.7 0.1 1.2 1 0 0 1 1 1 1 Sulfotransferase family Peptidase_C92 PF05708.12 EMC85694.1 - 0.0067 16.5 0.0 0.0096 16.0 0.0 1.3 1 0 0 1 1 1 1 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family DUF758 PF05527.11 EMC85694.1 - 0.042 13.8 0.0 0.062 13.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF758) Sulfotransfer_4 PF17784.1 EMC85694.1 - 0.055 13.3 0.2 0.15 11.9 0.2 1.5 1 1 0 1 1 1 0 Sulfotransferase domain NPA PF16469.5 EMC85694.1 - 0.063 13.9 0.1 0.16 12.6 0.1 1.6 1 1 0 1 1 1 0 Nematode polyprotein allergen ABA-1 FdsD PF11390.8 EMC85694.1 - 0.19 12.1 1.4 2.6 8.4 1.5 2.3 1 1 1 2 2 2 0 NADH-dependant formate dehydrogenase delta subunit FdsD Patatin PF01734.22 EMC85695.1 - 2.4e-06 27.9 0.0 4.6e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Patatin-like phospholipase FAM83 PF07894.12 EMC85696.1 - 3e-100 335.3 0.0 8.5e-100 333.8 0.0 1.9 1 0 0 1 1 1 1 FAM83 A-H PLDc_2 PF13091.6 EMC85696.1 - 0.0011 18.8 0.0 0.0034 17.3 0.0 1.8 1 0 0 1 1 1 1 PLD-like domain DUF3482 PF11981.8 EMC85696.1 - 0.33 10.3 1.5 0.82 9.0 1.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) YflT PF11181.8 EMC85696.1 - 1 9.9 3.2 1 9.9 0.3 2.5 2 0 0 2 2 2 0 Heat induced stress protein YflT PRY PF13765.6 EMC85700.1 - 4.8e-11 42.1 0.6 1.1e-10 41.0 0.6 1.6 1 1 0 1 1 1 1 SPRY-associated domain Ephrin PF00812.17 EMC85703.1 - 2.1e-51 173.6 0.3 2.1e-50 170.3 0.1 2.0 2 0 0 2 2 2 1 Ephrin TMEM132D_C PF15706.5 EMC85703.1 - 0.0021 17.8 0.0 0.0036 17.0 0.0 1.4 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term OSTbeta PF15048.6 EMC85703.1 - 0.054 13.6 0.1 12 6.1 0.0 2.3 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein RIFIN PF02009.16 EMC85703.1 - 0.06 13.2 0.0 0.07 13.0 0.0 1.1 1 0 0 1 1 1 0 Rifin EphA2_TM PF14575.6 EMC85703.1 - 0.07 14.0 0.0 0.15 13.0 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 EMC85703.1 - 0.086 12.7 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family ECSCR PF15820.5 EMC85703.1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Amnionless PF14828.6 EMC85703.1 - 0.11 11.3 0.0 0.18 10.6 0.0 1.3 1 0 0 1 1 1 0 Amnionless Stevor PF17410.2 EMC85703.1 - 0.17 11.4 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame UL45 PF05473.12 EMC85703.1 - 0.17 11.5 0.1 0.73 9.4 0.0 2.1 3 0 0 3 3 3 0 UL45 protein, carbohydrate-binding C-type lectin-like ARGLU PF15346.6 EMC85704.1 - 2.8e-52 176.6 59.2 2.8e-52 176.6 59.2 2.0 2 0 0 2 2 2 2 Arginine and glutamate-rich 1 DNA_ligase_A_M PF01068.21 EMC85707.1 - 5.3e-54 183.0 0.2 1.1e-53 181.9 0.2 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EMC85707.1 - 4.1e-41 141.2 0.2 9.1e-41 140.1 0.2 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_IV PF11411.8 EMC85707.1 - 5.9e-19 67.9 1.0 1.4e-18 66.7 1.0 1.7 1 0 0 1 1 1 1 DNA ligase IV DNA_ligase_A_C PF04679.15 EMC85707.1 - 1.7e-17 63.8 0.0 9.6e-17 61.4 0.0 2.3 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region BRCT PF00533.26 EMC85707.1 - 1.4e-14 54.2 0.1 1.1e-10 41.7 0.0 3.5 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EMC85707.1 - 3e-13 50.0 0.0 1e-09 38.7 0.0 2.8 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RNA_ligase PF09414.10 EMC85707.1 - 2e-10 41.2 0.1 4e-10 40.2 0.1 1.6 1 0 0 1 1 1 1 RNA ligase LIG3_BRCT PF16759.5 EMC85707.1 - 0.0066 16.7 0.1 2.4 8.5 0.0 2.9 3 0 0 3 3 3 1 DNA ligase 3 BRCT domain mRNA_cap_enzyme PF01331.19 EMC85707.1 - 0.065 13.1 0.6 0.53 10.1 0.6 2.2 1 1 0 1 1 1 0 mRNA capping enzyme, catalytic domain Tox-REase-9 PF15650.6 EMC85707.1 - 0.081 13.2 0.0 0.22 11.8 0.0 1.7 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 9 DUF2948 PF11164.8 EMC85707.1 - 0.083 12.9 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2948) BRCT_3 PF18428.1 EMC85707.1 - 0.23 11.5 1.7 21 5.2 0.0 3.8 4 0 0 4 4 4 0 BRCA1 C Terminus (BRCT) domain SKA1 PF07160.12 EMC85707.1 - 0.24 11.2 3.1 0.24 11.2 1.2 2.0 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Abhydrolase_1 PF00561.20 EMC85708.1 - 1.9e-16 60.5 0.0 8.8e-11 41.9 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMC85708.1 - 2.6e-15 56.3 0.0 1e-09 38.0 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 AXE1 PF05448.12 EMC85708.1 - 3.8e-08 32.4 0.0 0.00039 19.2 0.0 3.1 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 EMC85708.1 - 1.2e-06 29.3 0.0 1.1e-05 26.1 0.0 1.9 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EMC85708.1 - 5.5e-05 23.1 0.0 0.0036 17.1 0.0 2.6 2 1 1 3 3 3 1 Phospholipase/Carboxylesterase Peptidase_S15 PF02129.18 EMC85708.1 - 0.00087 19.0 0.0 0.016 14.8 0.0 2.0 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) BAAT_C PF08840.11 EMC85708.1 - 0.00087 19.3 0.0 0.0063 16.5 0.0 2.1 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_3 PF07859.13 EMC85708.1 - 0.0012 18.8 0.0 0.0016 18.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EMC85708.1 - 0.0014 18.2 0.0 0.0018 17.8 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family FSH1 PF03959.13 EMC85708.1 - 0.0021 17.8 0.0 0.0029 17.3 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DUF1057 PF06342.12 EMC85708.1 - 0.0063 15.6 0.1 0.0091 15.1 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) DLH PF01738.18 EMC85708.1 - 0.0081 15.7 0.0 0.042 13.4 0.0 1.9 1 1 0 1 1 1 1 Dienelactone hydrolase family DUF818 PF05677.12 EMC85708.1 - 0.029 13.3 0.0 0.044 12.7 0.0 1.2 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Esterase PF00756.20 EMC85708.1 - 0.032 13.9 0.0 0.048 13.3 0.0 1.3 1 0 0 1 1 1 0 Putative esterase PGAP1 PF07819.13 EMC85708.1 - 0.062 13.0 0.2 0.14 11.8 0.0 1.7 2 0 0 2 2 2 0 PGAP1-like protein PAF-AH_p_II PF03403.13 EMC85708.1 - 0.19 10.2 0.0 0.44 9.0 0.0 1.5 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II DUF5339 PF17274.2 EMC85708.1 - 0.2 12.5 0.0 0.33 11.9 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5339) TNF PF00229.18 EMC85709.1 - 3.8e-10 39.8 0.0 6.6e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family KRAP_IP3R_bind PF14722.6 EMC85711.1 - 1.9e-57 193.1 1.9 2.1e-56 189.7 0.1 2.4 2 0 0 2 2 2 1 Ki-ras-induced actin-interacting protein-IP3R-interacting domain SSFA2_C PF14723.6 EMC85711.1 - 3.1e-08 33.7 4.0 1.1e-07 32.0 4.0 1.9 1 0 0 1 1 1 1 Sperm-specific antigen 2 C-terminus Neuro_bHLH PF12533.8 EMC85712.1 - 2.6e-41 141.7 4.0 5.4e-41 140.7 4.0 1.5 1 0 0 1 1 1 1 Neuronal helix-loop-helix transcription factor HLH PF00010.26 EMC85712.1 - 6.6e-16 58.0 0.7 6.6e-16 58.0 0.7 1.7 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain FH2 PF02181.23 EMC85712.1 - 0.024 13.8 0.3 0.43 9.7 0.0 2.0 2 0 0 2 2 2 0 Formin Homology 2 Domain CDC45 PF02724.14 EMC85712.1 - 4.1 5.6 7.6 5.2 5.2 7.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Integrin_alpha2 PF08441.12 EMC85713.1 - 2.6e-92 310.1 0.0 5e-92 309.2 0.0 1.4 2 0 0 2 2 2 1 Integrin alpha FG-GAP PF01839.23 EMC85713.1 - 3.8e-24 84.5 18.1 8.2e-11 41.8 0.0 4.9 5 0 0 5 5 5 4 FG-GAP repeat VCBS PF13517.6 EMC85713.1 - 1.1e-12 48.3 14.3 1.7e-09 38.1 1.9 3.1 1 1 2 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.20 EMC85713.1 - 0.00032 20.4 0.3 0.00099 18.9 0.3 1.9 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region FG-GAP_2 PF14312.6 EMC85713.1 - 1.1 9.6 14.2 0.16 12.3 1.2 4.4 5 0 0 5 5 5 0 FG-GAP repeat GRIP PF01465.20 EMC85714.1 - 1.2e-09 38.0 0.3 5.5e-09 35.8 0.1 2.4 2 0 0 2 2 2 1 GRIP domain 7tm_4 PF13853.6 EMC85715.1 - 1.6e-16 60.9 0.8 1.8e-16 60.7 0.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC85715.1 - 0.11 11.8 2.6 0.14 11.4 2.6 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Peptidase_M28 PF04389.17 EMC85716.1 - 8.4e-07 28.9 0.0 4.3e-06 26.6 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M28 PA PF02225.22 EMC85716.1 - 0.0017 18.3 0.0 0.0036 17.3 0.0 1.5 1 0 0 1 1 1 1 PA domain TFR_dimer PF04253.15 EMC85716.1 - 0.0071 16.4 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain DUF4731 PF15875.5 EMC85716.1 - 0.13 12.5 0.7 2.5 8.3 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4731) WD40 PF00400.32 EMC85717.1 - 2.1e-52 173.9 25.6 3.5e-10 40.3 0.2 8.5 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC85717.1 - 4.2e-29 100.7 2.0 6.9e-08 32.7 0.1 6.3 3 2 4 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC85717.1 - 1.6e-11 44.5 0.5 0.001 19.0 0.1 3.4 1 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A LisH PF08513.11 EMC85717.1 - 6e-10 38.7 0.1 3.7e-09 36.2 0.0 2.2 2 0 0 2 2 2 1 LisH WD40_like PF17005.5 EMC85717.1 - 4.1e-05 23.1 0.0 0.081 12.2 0.0 3.1 4 1 0 4 4 4 2 WD40-like domain Coatomer_WDAD PF04053.14 EMC85717.1 - 0.00013 21.2 0.0 0.0047 16.0 0.0 2.4 2 0 0 2 2 2 1 Coatomer WD associated region Ge1_WD40 PF16529.5 EMC85717.1 - 0.00014 20.9 1.3 0.78 8.6 0.0 3.4 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EMC85717.1 - 0.0064 15.2 4.6 0.67 8.5 0.0 3.8 2 2 2 4 4 4 2 Nucleoporin Nup120/160 PD40 PF07676.12 EMC85717.1 - 0.032 14.2 0.0 0.49 10.4 0.0 3.0 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Glyco_hydro_11 PF00457.17 EMC85717.1 - 0.053 13.2 1.2 1.7 8.2 0.1 2.7 2 0 0 2 2 2 0 Glycosyl hydrolases family 11 PCuAC PF04314.13 EMC85717.1 - 0.13 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Copper chaperone PCu(A)C IKI3 PF04762.12 EMC85717.1 - 0.21 9.6 0.3 4.7 5.1 0.0 2.5 2 1 1 3 3 3 0 IKI3 family CaKB PF03185.15 EMC85718.1 - 2.5e-85 285.1 9.2 2.8e-85 284.9 9.2 1.0 1 0 0 1 1 1 1 Calcium-activated potassium channel, beta subunit AAA_8 PF12780.7 EMC85718.1 - 0.00071 19.0 0.1 0.00088 18.7 0.1 1.1 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 tRNA-synt_1g PF09334.11 EMC85718.1 - 0.0044 15.8 0.0 0.0064 15.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) zf-met PF12874.7 EMC85719.1 - 2.1e-22 78.8 16.9 1.5e-08 34.8 0.4 3.4 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMC85719.1 - 1e-19 70.3 16.7 9.5e-07 29.0 0.2 3.3 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EMC85719.1 - 4.8e-09 36.5 11.8 0.017 15.5 0.4 3.2 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EMC85719.1 - 0.00038 21.0 5.8 2.6 9.1 0.1 3.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-U1 PF06220.12 EMC85719.1 - 0.00093 18.9 18.2 0.1 12.4 3.0 3.6 3 1 0 3 3 3 2 U1 zinc finger AKAP95 PF04988.12 EMC85719.1 - 0.0074 16.5 9.1 0.011 16.0 0.7 3.0 3 0 0 3 3 3 1 A-kinase anchoring protein 95 (AKAP95) PI3Ka PF00613.20 EMC85720.1 - 1.9e-69 232.8 1.9 1.9e-69 232.8 1.9 2.0 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EMC85720.1 - 9.5e-56 189.4 2.4 6.5e-55 186.6 2.4 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_rbd PF00794.18 EMC85720.1 - 4.2e-39 133.0 1.4 3e-37 127.1 0.7 2.9 2 0 0 2 2 2 1 PI3-kinase family, ras-binding domain PI3K_C2 PF00792.24 EMC85720.1 - 5.7e-33 113.8 0.0 1.1e-32 112.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_p85B PF02192.16 EMC85720.1 - 8.5e-31 105.5 0.4 2.2e-30 104.2 0.4 1.8 1 0 0 1 1 1 1 PI3-kinase family, p85-binding domain DUF2321 PF10083.9 EMC85720.1 - 0.018 14.7 0.0 0.043 13.5 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) DUF4135 PF13575.6 EMC85720.1 - 0.1 11.9 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) zf-C2H2 PF00096.26 EMC85721.1 - 7.2e-17 60.8 59.4 0.0025 18.2 1.0 9.6 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC85721.1 - 4.3e-14 52.0 60.3 0.0051 17.6 1.3 9.8 9 0 0 9 9 9 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC85721.1 - 1.6e-11 44.1 49.6 0.00017 21.8 0.2 9.7 9 0 0 9 9 9 5 Zinc-finger double domain zf-H2C2_5 PF13909.6 EMC85721.1 - 1.4e-10 40.7 42.3 0.00032 20.4 0.3 7.9 8 0 0 8 8 8 3 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.6 EMC85721.1 - 0.0017 18.3 1.3 0.0017 18.3 1.3 8.3 8 1 0 8 8 8 2 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 EMC85721.1 - 0.0029 17.2 44.6 0.021 14.5 0.2 6.9 5 2 1 6 6 6 3 Zinc-fingers and homeoboxes C2H2 finger domain zf-met PF12874.7 EMC85721.1 - 0.061 13.7 1.0 0.061 13.7 1.0 7.5 8 0 0 8 8 8 0 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 EMC85721.1 - 0.086 13.1 30.3 0.15 12.4 2.1 5.1 1 1 3 5 5 5 0 C2H2-type zinc ribbon zinc_ribbon_15 PF17032.5 EMC85721.1 - 0.21 12.3 34.1 0.19 12.5 3.5 5.0 3 1 2 5 5 5 0 zinc-ribbon family CarbpepA_inh PF02977.15 EMC85721.1 - 1.6 8.6 14.7 1.9 8.4 0.0 5.0 5 0 0 5 5 5 0 Carboxypeptidase A inhibitor zf-C2H2_2 PF12756.7 EMC85721.1 - 2.7 8.4 50.5 6.4 7.2 13.6 5.9 1 1 5 6 6 6 0 C2H2 type zinc-finger (2 copies) Fzo_mitofusin PF04799.13 EMC85722.1 - 2.7e-72 241.6 6.1 2.7e-72 241.6 6.1 3.3 2 1 1 3 3 3 1 fzo-like conserved region Dynamin_N PF00350.23 EMC85722.1 - 1.1e-23 84.1 0.0 1.1e-23 84.1 0.0 4.0 4 1 0 4 4 4 1 Dynamin family MMR_HSR1 PF01926.23 EMC85722.1 - 3.5e-08 33.5 0.1 3.5e-07 30.3 0.0 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 EMC85722.1 - 0.084 13.1 0.1 14 6.0 0.0 3.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Phospholip_A2_3 PF09056.11 EMC85722.1 - 0.31 11.7 2.4 1.5 9.4 0.1 3.0 3 0 0 3 3 3 0 Prokaryotic phospholipase A2 CLZ PF16526.5 EMC85722.1 - 0.54 10.7 9.0 2.6 8.5 0.2 3.9 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels HEPN_Swt1 PF18731.1 EMC85722.1 - 0.81 10.1 5.4 3 8.2 0.0 3.6 3 0 0 3 3 3 0 Swt1-like HEPN Tup_N PF08581.10 EMC85722.1 - 1.1 9.6 11.0 2.9 8.2 0.2 3.8 3 0 0 3 3 3 0 Tup N-terminal YtxH PF12732.7 EMC85722.1 - 1.7 9.2 6.6 0.87 10.2 2.6 2.7 2 1 0 2 2 2 0 YtxH-like protein TMF_TATA_bd PF12325.8 EMC85722.1 - 4.3 7.6 14.0 0.3 11.3 4.0 3.5 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding FadA PF09403.10 EMC85722.1 - 5.4 7.6 12.3 0.36 11.3 1.4 3.6 2 2 1 3 3 3 0 Adhesion protein FadA AAA_23 PF13476.6 EMC85722.1 - 7.1 7.1 0.0 7.1 7.1 0.0 3.6 3 1 0 3 3 3 0 AAA domain WD40 PF00400.32 EMC85723.1 - 1.2e-44 149.3 21.2 3.8e-08 33.9 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC85723.1 - 1.7e-16 60.3 0.0 0.00085 19.6 0.0 5.7 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC85723.1 - 6.8e-05 22.8 0.0 0.36 10.7 0.0 2.8 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EMC85723.1 - 8.8e-05 22.0 0.0 0.023 14.0 0.0 2.9 1 1 1 2 2 2 2 WD40-like domain Actin PF00022.19 EMC85724.1 - 6.4e-149 496.0 0.0 7.1e-149 495.8 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EMC85724.1 - 0.0027 16.6 0.0 0.013 14.3 0.0 1.9 2 0 0 2 2 2 1 MreB/Mbl protein MobA_MobL PF03389.15 EMC85724.1 - 0.18 11.5 0.0 0.31 10.8 0.0 1.3 1 0 0 1 1 1 0 MobA/MobL family MRP-L47 PF06984.13 EMC85725.1 - 6.6e-29 99.9 2.0 6.6e-29 99.9 2.0 1.6 2 0 0 2 2 2 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) DUF2737 PF10930.8 EMC85725.1 - 0.055 13.0 0.5 0.16 11.5 0.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2737) Tnp_22_trimer PF17489.2 EMC85725.1 - 0.18 11.8 0.1 0.18 11.8 0.1 2.0 2 0 0 2 2 2 0 L1 transposable element trimerization domain NDUF_B5 PF09781.9 EMC85726.1 - 2.1e-72 242.6 4.2 1.6e-69 233.2 4.2 2.0 1 1 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit UCH PF00443.29 EMC85727.1 - 4.4e-47 160.7 0.0 5.9e-47 160.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 EMC85727.1 - 7.9e-25 86.4 0.5 2.4e-12 46.5 0.1 3.2 3 0 0 3 3 3 2 UBA/TS-N domain zf-UBP PF02148.19 EMC85727.1 - 7.9e-17 61.3 2.0 6.7e-15 55.2 0.0 2.7 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein zf-UBP_var PF17807.1 EMC85727.1 - 1.8e-13 50.0 1.1 1.2e-12 47.4 0.3 2.4 2 0 0 2 2 2 1 Variant UBP zinc finger UCH_1 PF13423.6 EMC85727.1 - 9.1e-11 41.9 0.0 0.00079 19.1 0.0 3.1 3 0 0 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase UBA_4 PF14555.6 EMC85727.1 - 0.0099 15.7 0.1 0.02 14.7 0.1 1.5 1 0 0 1 1 1 1 UBA-like domain UBA_3 PF09288.10 EMC85727.1 - 0.075 12.9 0.0 1.5 8.7 0.0 2.6 2 0 0 2 2 2 0 Fungal ubiquitin-associated domain TPR_1 PF00515.28 EMC85728.1 - 2.3e-26 90.5 1.0 2e-05 24.2 0.0 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 EMC85728.1 - 5.2e-22 76.1 5.6 0.00021 21.2 0.0 6.2 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 EMC85728.1 - 1.1e-19 68.9 0.3 0.0023 18.0 0.0 5.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 EMC85728.1 - 5.8e-15 54.7 1.0 0.0015 18.1 0.0 5.5 3 2 2 5 5 5 3 TPR repeat TPR_14 PF13428.6 EMC85728.1 - 1.5e-14 53.4 6.6 0.0037 18.0 0.7 6.5 2 2 4 6 6 6 5 Tetratricopeptide repeat TPR_19 PF14559.6 EMC85728.1 - 4e-14 52.9 5.6 0.00093 19.7 2.3 4.6 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.6 EMC85728.1 - 1.2e-13 50.4 9.3 0.0052 17.1 0.5 5.7 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_9 PF13371.6 EMC85728.1 - 1.4e-11 44.3 2.1 0.00026 21.1 0.4 4.2 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 EMC85728.1 - 4.2e-11 43.3 6.9 6.7e-06 26.6 0.4 4.3 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_20 PF14561.6 EMC85728.1 - 8.4e-09 35.6 3.9 0.00021 21.6 0.6 4.4 2 2 2 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EMC85728.1 - 1.7e-08 33.9 1.9 2.2 8.5 0.1 6.1 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 EMC85728.1 - 2.7e-08 34.0 6.2 0.78 10.1 0.0 4.6 2 2 1 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC85728.1 - 6.5e-08 32.7 2.1 0.0014 18.8 1.7 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EMC85728.1 - 5.2e-07 29.9 4.8 6.3 7.7 0.2 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_3 PF07720.12 EMC85728.1 - 0.0053 16.7 0.0 5 7.2 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 EMC85728.1 - 0.0058 16.1 5.2 7.6 6.1 0.1 3.6 3 0 0 3 3 3 1 SHNi-TPR TPR_15 PF13429.6 EMC85728.1 - 0.0077 15.5 4.1 0.058 12.6 0.7 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF4248 PF14053.6 EMC85728.1 - 0.012 15.6 0.2 0.034 14.2 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4248) DUF4919 PF16266.5 EMC85728.1 - 0.033 14.1 0.2 0.091 12.7 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4919) BTAD PF03704.17 EMC85728.1 - 0.036 14.5 4.7 7.9 6.9 0.1 3.8 4 0 0 4 4 3 0 Bacterial transcriptional activator domain Wzy_C_2 PF11846.8 EMC85728.1 - 0.092 12.7 0.6 0.24 11.3 0.6 1.7 1 0 0 1 1 1 0 Virulence factor membrane-bound polymerase, C-terminal DUF4192 PF13830.6 EMC85728.1 - 0.52 10.3 3.1 0.91 9.5 0.0 2.6 3 0 0 3 3 2 0 Domain of unknown function (DUF4192) TPR_1 PF00515.28 EMC85729.1 - 3.3e-13 48.8 0.2 0.00071 19.3 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EMC85729.1 - 2.3e-12 46.0 3.6 0.0005 20.0 0.0 4.9 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 EMC85729.1 - 2.2e-10 40.1 0.5 6e-09 35.4 0.1 2.9 2 1 0 2 2 2 1 TPR repeat TPR_8 PF13181.6 EMC85729.1 - 7.2e-08 32.1 0.3 0.065 13.5 0.0 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMC85729.1 - 2.5e-07 30.9 0.1 0.038 14.8 0.0 3.7 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMC85729.1 - 1.5e-06 28.8 0.1 1.5e-05 25.6 0.0 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 EMC85729.1 - 2.8e-06 27.3 0.4 0.00035 20.7 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 EMC85729.1 - 8e-06 25.9 0.0 2.8e-05 24.2 0.0 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMC85729.1 - 0.00084 19.6 1.6 1.1 9.6 0.5 3.1 1 1 3 4 4 4 2 Tetratricopeptide repeat HCNGP PF07818.13 EMC85729.1 - 0.0011 19.6 2.9 0.0023 18.6 0.0 2.6 2 0 0 2 2 2 1 HCNGP-like protein TPR_19 PF14559.6 EMC85729.1 - 0.0013 19.2 4.0 0.022 15.2 0.1 3.5 1 1 3 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 EMC85729.1 - 0.003 16.8 2.3 0.0057 15.9 2.3 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat S1 PF00575.23 EMC85729.1 - 0.0039 17.5 0.0 0.14 12.5 0.0 2.5 1 1 0 1 1 1 1 S1 RNA binding domain Aida_N PF08910.10 EMC85729.1 - 1.2 9.5 5.0 25 5.3 3.3 2.5 2 0 0 2 2 2 0 Aida N-terminus CENP-F_leu_zip PF10473.9 EMC85730.1 - 6.8e-05 22.9 25.2 6.8e-05 22.9 25.2 8.5 1 1 7 9 9 9 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF2205 PF10224.9 EMC85730.1 - 0.0058 16.6 4.0 0.0058 16.6 4.0 8.9 6 2 1 8 8 8 1 Short coiled-coil protein TPR_MLP1_2 PF07926.12 EMC85730.1 - 0.0061 16.6 19.7 0.0061 16.6 19.7 8.7 4 1 3 8 8 8 2 TPR/MLP1/MLP2-like protein Macro_2 PF14519.6 EMC85730.1 - 0.14 11.4 0.5 0.41 9.9 0.5 1.7 1 0 0 1 1 1 0 Macro-like domain Spc7 PF08317.11 EMC85730.1 - 8.6 5.1 155.9 0.7 8.7 15.3 6.9 2 2 4 6 6 6 0 Spc7 kinetochore protein FXMRP1_C_core PF12235.8 EMC85731.1 - 1.2e-46 158.7 14.4 1.2e-46 158.7 14.4 3.2 1 1 2 3 3 3 1 Fragile X-related 1 protein core C terminal FXR_C1 PF16096.5 EMC85731.1 - 3.7e-39 132.8 10.6 3.7e-39 132.8 10.6 2.6 2 0 0 2 2 2 1 Fragile X-related 1 protein C-terminal region 2 KH_9 PF17904.1 EMC85731.1 - 1.5e-35 121.4 0.7 3.4e-35 120.3 0.7 1.6 1 0 0 1 1 1 1 FMRP KH0 domain FXR_C3 PF16097.5 EMC85731.1 - 3.6e-27 94.8 8.8 3.6e-27 94.8 8.8 2.8 4 0 0 4 4 4 1 Fragile X-related 1 protein C-terminal region 3 KH_1 PF00013.29 EMC85731.1 - 2e-17 62.7 1.0 1.5e-09 37.6 0.5 2.8 2 0 0 2 2 2 2 KH domain Agenet PF05641.12 EMC85731.1 - 1.9e-08 34.6 0.2 1.9e-08 34.6 0.2 2.9 3 0 0 3 3 3 1 Agenet domain Tudor_FRX1 PF18336.1 EMC85731.1 - 9.5e-07 28.6 1.3 9.5e-07 28.6 1.3 2.0 2 0 0 2 2 2 1 Fragile X mental retardation Tudor domain KH_2 PF07650.17 EMC85731.1 - 0.00023 20.9 0.8 0.15 11.9 0.0 2.6 2 0 0 2 2 2 2 KH domain KH_4 PF13083.6 EMC85731.1 - 0.36 10.7 5.0 2.1 8.3 0.4 3.5 3 1 1 4 4 4 0 KH domain Tombus_movement PF05318.12 EMC85731.1 - 0.59 11.0 6.8 0.69 10.8 0.5 2.8 1 1 1 2 2 2 0 Tombusvirus movement protein SOXp PF12336.8 EMC85733.1 - 2.3e-38 131.1 5.5 2.3e-38 131.1 5.5 2.4 3 0 0 3 3 3 1 SOX transcription factor HMG_box PF00505.19 EMC85733.1 - 5.2e-28 97.3 3.4 8.7e-28 96.5 3.4 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC85733.1 - 5.9e-12 46.0 1.9 1.1e-11 45.2 1.9 1.5 1 0 0 1 1 1 1 HMG-box domain PhoLip_ATPase_C PF16212.5 EMC85736.1 - 1.1e-77 261.2 37.6 1.1e-77 261.2 37.6 2.2 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EMC85736.1 - 1.9e-22 78.7 1.8 1e-21 76.3 1.8 2.4 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EMC85736.1 - 2e-13 51.1 0.7 5.5e-08 33.4 0.5 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EMC85736.1 - 8.7e-10 38.6 0.0 6.4e-09 35.8 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EMC85736.1 - 1.1e-09 38.0 0.2 1.1e-09 38.0 0.2 3.0 2 2 1 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EMC85736.1 - 0.00024 20.9 0.0 0.008 15.9 0.0 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EMC85736.1 - 0.062 13.7 0.1 17 5.8 0.0 2.4 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Cullin_binding PF03556.15 EMC85737.1 - 1.4e-37 128.8 0.9 1.4e-37 128.8 0.9 2.1 2 0 0 2 2 2 1 Cullin binding UBA_4 PF14555.6 EMC85737.1 - 1.1e-09 38.0 3.0 1.3e-09 37.7 0.1 2.7 3 0 0 3 3 3 1 UBA-like domain TAP_C PF03943.13 EMC85737.1 - 0.0038 16.8 0.8 0.024 14.3 0.2 2.7 3 0 0 3 3 3 1 TAP C-terminal domain CPSase_L_D2 PF02786.17 EMC85738.1 - 1.9e-77 259.5 0.1 3.4e-77 258.7 0.1 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EMC85738.1 - 1.1e-48 164.4 1.5 1.7e-47 160.5 0.3 2.5 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EMC85738.1 - 2e-35 121.1 0.0 1.3e-34 118.5 0.0 2.3 3 0 0 3 3 3 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EMC85738.1 - 1.2e-15 57.1 0.9 1.2e-15 57.1 0.9 2.2 2 0 0 2 2 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EMC85738.1 - 7.2e-14 51.8 0.0 2.4e-13 50.1 0.0 1.8 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EMC85738.1 - 1.8e-09 37.4 0.1 4.1e-09 36.2 0.1 1.6 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 EMC85738.1 - 7.3e-06 25.7 0.0 3.1e-05 23.6 0.0 1.9 1 1 0 1 1 1 1 RimK-like ATP-grasp domain Biotin_lipoyl_2 PF13533.6 EMC85738.1 - 1.6e-05 24.6 0.5 0.0082 16.0 0.0 3.1 3 0 0 3 3 3 1 Biotin-lipoyl like ATP-grasp_3 PF02655.14 EMC85738.1 - 1.8e-05 24.9 0.0 3.3e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain HlyD_3 PF13437.6 EMC85738.1 - 8.4e-05 23.2 0.2 0.25 12.1 0.0 3.1 2 0 0 2 2 2 2 HlyD family secretion protein GARS_A PF01071.19 EMC85738.1 - 0.0009 19.1 0.0 0.0016 18.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain HlyD_D23 PF16576.5 EMC85738.1 - 0.0012 18.1 0.1 0.96 8.6 0.0 2.4 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATPgrasp_ST PF14397.6 EMC85738.1 - 0.002 17.5 0.5 0.3 10.3 0.0 2.8 3 0 0 3 3 3 1 Sugar-transfer associated ATP-grasp RnfC_N PF13375.6 EMC85738.1 - 0.028 14.4 0.6 0.086 12.8 0.3 2.0 2 0 0 2 2 1 0 RnfC Barrel sandwich hybrid domain ATP-grasp_4 PF13535.6 EMC85738.1 - 0.034 13.8 0.1 0.12 11.9 0.0 2.0 2 0 0 2 2 2 0 ATP-grasp domain Ntox43 PF15537.6 EMC85738.1 - 0.11 12.5 0.0 0.31 11.1 0.0 1.7 1 0 0 1 1 1 0 Bacterial toxin 43 NQRA PF05896.11 EMC85738.1 - 0.12 11.8 0.5 0.24 10.8 0.5 1.4 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) Mitofilin PF09731.9 EMC85739.1 - 2.6 6.8 9.0 2.9 6.6 9.0 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein EBP50_C PF09007.11 EMC85740.1 - 0.35 11.9 9.1 0.064 14.3 4.9 1.9 1 1 0 2 2 2 0 EBP50, C-terminal RhoGEF PF00621.20 EMC85741.1 - 2.2e-31 109.5 7.2 2.2e-31 109.5 7.2 2.9 3 1 0 3 3 3 1 RhoGEF domain CRAL_TRIO_2 PF13716.6 EMC85741.1 - 1.1e-05 25.7 0.0 3.5e-05 24.0 0.0 1.9 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain PH_10 PF15411.6 EMC85741.1 - 0.00018 21.8 0.2 0.00018 21.8 0.2 3.0 4 0 0 4 4 4 1 Pleckstrin homology domain Spectrin PF00435.21 EMC85741.1 - 0.00023 21.6 0.3 0.00023 21.6 0.3 4.5 3 1 2 5 5 5 2 Spectrin repeat CRAL_TRIO PF00650.20 EMC85741.1 - 0.1 12.3 0.0 0.25 11.1 0.0 1.7 1 0 0 1 1 1 0 CRAL/TRIO domain Ku_C PF03730.14 EMC85741.1 - 0.51 11.1 3.3 8.4 7.2 0.4 3.3 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm Goodbye PF17109.5 EMC85741.1 - 1.3 9.5 4.5 1.6 9.2 0.1 3.4 5 0 0 5 5 5 0 fungal STAND N-terminal Goodbye domain Galactosyl_T PF01762.21 EMC85742.1 - 2e-47 161.5 0.0 3.3e-47 160.9 0.0 1.3 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 EMC85742.1 - 0.00083 18.9 0.0 0.0011 18.4 0.0 1.3 1 0 0 1 1 1 1 Fringe-like Rep_fac_C PF08542.11 EMC85743.1 - 7.9e-20 71.1 0.3 1.6e-19 70.1 0.3 1.5 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 EMC85743.1 - 1.4e-17 64.3 0.1 5.5e-17 62.4 0.0 2.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EMC85743.1 - 1.3e-12 47.8 0.0 1.7e-10 40.9 0.0 2.5 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_assoc_2 PF16193.5 EMC85743.1 - 4.6e-06 26.9 0.0 1.4e-05 25.4 0.0 1.9 1 0 0 1 1 1 1 AAA C-terminal domain AAA_16 PF13191.6 EMC85743.1 - 4.6e-06 27.1 0.3 0.0032 17.9 0.0 2.8 2 2 1 3 3 3 1 AAA ATPase domain Rad17 PF03215.15 EMC85743.1 - 1.4e-05 25.2 0.0 2.9e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_30 PF13604.6 EMC85743.1 - 4.4e-05 23.3 0.2 0.00015 21.6 0.0 1.9 3 0 0 3 3 3 1 AAA domain AAA_11 PF13086.6 EMC85743.1 - 0.00014 21.8 0.2 0.00051 19.9 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EMC85743.1 - 0.00018 21.8 0.0 0.01 16.1 0.0 2.6 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EMC85743.1 - 0.00037 20.3 0.0 0.00084 19.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 EMC85743.1 - 0.00042 19.6 0.0 0.0009 18.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) DNA_pol3_delta PF06144.13 EMC85743.1 - 0.00056 19.7 0.1 0.0013 18.5 0.1 1.6 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Mg_chelatase PF01078.21 EMC85743.1 - 0.0011 18.4 0.0 0.035 13.5 0.0 2.7 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 EMC85743.1 - 0.0034 17.7 0.1 0.037 14.3 0.0 2.4 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 EMC85743.1 - 0.0086 15.8 0.0 0.021 14.6 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49_C PF17856.1 EMC85743.1 - 0.013 15.6 0.1 0.037 14.2 0.1 1.8 1 0 0 1 1 1 0 TIP49 AAA-lid domain AAA_5 PF07728.14 EMC85743.1 - 0.017 15.2 0.2 0.12 12.3 0.0 2.5 2 1 0 2 2 1 0 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 EMC85743.1 - 0.024 14.4 0.0 0.78 9.4 0.0 2.3 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_23 PF13476.6 EMC85743.1 - 0.03 14.8 0.0 0.09 13.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EMC85743.1 - 0.033 13.4 0.0 0.23 10.7 0.0 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_3 PF07726.11 EMC85743.1 - 0.065 13.1 0.0 0.19 11.6 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EMC85743.1 - 0.075 13.3 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 EMC85743.1 - 0.078 12.7 0.0 1.7 8.4 0.0 2.6 1 1 1 2 2 2 0 DEAD/DEAH box helicase PhoH PF02562.16 EMC85743.1 - 0.084 12.3 0.0 6.4 6.2 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein ResIII PF04851.15 EMC85743.1 - 0.086 12.8 0.0 0.42 10.6 0.0 1.9 1 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_7 PF12775.7 EMC85743.1 - 0.13 11.7 0.0 0.29 10.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region DEAD PF00270.29 EMC85744.1 - 9e-44 149.3 0.3 1.6e-43 148.5 0.3 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC85744.1 - 2.4e-32 111.6 0.5 8.2e-31 106.6 0.1 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC85744.1 - 1.5e-07 31.6 0.0 2.7e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EMC85744.1 - 5.2e-05 23.6 0.3 0.0002 21.7 0.1 2.0 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EMC85744.1 - 0.001 18.8 0.0 0.0018 18.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 EMC85744.1 - 0.067 13.2 0.0 0.29 11.1 0.0 2.0 2 0 0 2 2 2 0 Flavivirus DEAD domain Helicase_RecD PF05127.14 EMC85744.1 - 0.069 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Helicase tRNA-synt_1b PF00579.25 EMC85744.1 - 0.076 12.3 0.1 0.24 10.7 0.0 1.9 3 0 0 3 3 3 0 tRNA synthetases class I (W and Y) AAA_22 PF13401.6 EMC85744.1 - 0.097 12.9 0.3 1.1 9.5 0.3 2.4 1 1 0 1 1 1 0 AAA domain UvrD-helicase PF00580.21 EMC85744.1 - 0.13 11.7 0.2 0.23 11.0 0.1 1.4 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain Fanconi_A PF03511.14 EMC85744.1 - 0.15 12.0 0.0 26 4.8 0.0 2.4 2 0 0 2 2 2 0 Fanconi anaemia group A protein Cystatin PF00031.21 EMC85745.1 - 1.3e-43 147.1 2.6 1.4e-22 79.8 0.1 2.2 2 0 0 2 2 2 2 Cystatin domain Cathelicidins PF00666.17 EMC85745.1 - 2.7e-14 53.3 2.7 4.5e-07 30.1 0.4 2.2 2 0 0 2 2 2 2 Cathelicidin SQAPI PF16845.5 EMC85745.1 - 1.8e-07 31.4 0.2 0.00014 22.2 0.1 2.2 2 0 0 2 2 2 2 Aspartic acid proteinase inhibitor Spp-24 PF07448.11 EMC85745.1 - 9.6e-05 22.5 3.8 0.0023 18.1 1.2 2.4 2 0 0 2 2 2 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain DUF2028 PF09667.10 EMC85745.1 - 0.011 15.8 2.3 0.013 15.5 2.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2028) AvrLm4-7 PF18661.1 EMC85745.1 - 7.7 7.6 10.0 14 6.8 0.3 2.7 2 1 0 2 2 2 0 Avirulence Effector AvrLm4-7 Anticodon_1 PF08264.13 EMC85746.1 - 4.2 7.3 5.6 29 4.6 0.8 2.9 2 0 0 2 2 2 0 Anticodon-binding domain of tRNA PIG-P PF08510.12 EMC85746.1 - 7.2 6.5 16.0 0.28 11.1 6.8 2.6 1 1 1 2 2 2 0 PIG-P Cystatin PF00031.21 EMC85748.1 - 6.3e-10 39.2 0.0 0.0013 19.0 0.0 2.6 3 0 0 3 3 3 2 Cystatin domain Peptidase_C48 PF02902.19 EMC85749.1 - 3.1e-43 148.1 2.3 5.6e-43 147.3 2.3 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DEK_C PF08766.11 EMC85749.1 - 0.023 14.6 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 DEK C terminal domain Pkinase_Tyr PF07714.17 EMC85751.1 - 5.4e-94 314.3 0.0 9.6e-94 313.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.19 EMC85751.1 - 5.7e-74 248.0 0.5 8.8e-74 247.4 0.5 1.3 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.25 EMC85751.1 - 1e-44 152.9 0.0 1.5e-44 152.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 EMC85751.1 - 3.1e-33 114.0 4.6 1.5e-15 57.2 0.1 3.8 4 0 0 4 4 4 2 Fibronectin type III domain SAM_1 PF00536.30 EMC85751.1 - 5.8e-22 77.9 0.0 1.2e-21 76.9 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) EphA2_TM PF14575.6 EMC85751.1 - 6.9e-22 78.1 0.3 1.6e-21 76.9 0.3 1.6 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_2 PF07647.17 EMC85751.1 - 1e-21 76.8 0.0 2.1e-21 75.8 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pur_ac_phosph_N PF16656.5 EMC85751.1 - 6.9e-06 26.5 0.5 0.00015 22.2 0.1 2.9 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.5 EMC85751.1 - 1.5e-05 25.1 0.2 0.13 12.4 0.0 3.2 3 0 0 3 3 3 2 Fibronectin type III domain Ephrin_rec_like PF07699.13 EMC85751.1 - 0.00044 20.0 10.2 0.00044 20.0 10.2 2.6 3 1 0 3 3 2 1 Putative ephrin-receptor like Interfer-bind PF09294.10 EMC85751.1 - 0.0022 18.3 0.0 0.16 12.3 0.0 2.8 3 0 0 3 3 3 1 Interferon-alpha/beta receptor, fibronectin type III SusE PF14292.6 EMC85751.1 - 0.0087 16.3 0.1 0.84 9.9 0.0 2.5 2 0 0 2 2 2 1 SusE outer membrane protein Haspin_kinase PF12330.8 EMC85751.1 - 0.049 12.6 0.0 0.082 11.8 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain DUF2039 PF10217.9 EMC85751.1 - 1.2 9.5 4.9 0.59 10.5 1.3 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) RNA_pol_Rpb8 PF03870.15 EMC85752.1 - 8.4e-44 149.1 0.1 9.4e-44 149.0 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 EMC85752.1 - 0.00037 20.5 0.0 0.031 14.3 0.0 2.1 2 0 0 2 2 2 2 DNA-directed RNA polymerase, subunit G EPO_TPO PF00758.18 EMC85753.1 - 3.9e-26 92.0 0.4 4.7e-26 91.7 0.4 1.1 1 0 0 1 1 1 1 Erythropoietin/thrombopoietin CHRD PF07452.12 EMC85754.1 - 5.5e-26 91.8 0.0 3.8e-12 47.2 0.0 3.2 3 0 0 3 3 3 3 CHRD domain VWC PF00093.18 EMC85754.1 - 0.14 12.5 7.3 0.23 11.8 7.3 1.4 1 0 0 1 1 1 0 von Willebrand factor type C domain Amnionless PF14828.6 EMC85754.1 - 0.41 9.4 10.3 0.62 8.8 10.3 1.2 1 0 0 1 1 1 0 Amnionless CHRD PF07452.12 EMC85755.1 - 3.2e-06 28.1 0.0 3.4e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 CHRD domain Voltage_CLC PF00654.20 EMC85756.1 - 2.9e-93 312.9 25.4 2.9e-93 312.9 25.4 1.9 1 1 1 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EMC85756.1 - 0.067 13.6 0.3 3.2 8.3 0.1 2.7 2 0 0 2 2 2 0 CBS domain DEC-1_N PF04625.13 EMC85756.1 - 0.27 10.2 1.8 0.48 9.4 1.8 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region HSP20 PF00011.21 EMC85757.1 - 1.3e-10 41.4 0.0 1.5e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family FAM131 PF15010.6 EMC85758.1 - 1.5e-120 402.6 6.5 1.4e-119 399.4 6.5 1.9 1 1 0 1 1 1 1 Putative cell signalling PT PF04886.12 EMC85758.1 - 3.8 7.1 7.9 0.31 10.6 3.1 1.7 2 0 0 2 2 2 0 PT repeat MIF4G PF02854.19 EMC85759.1 - 2.3e-68 230.0 9.6 2.3e-68 230.0 9.6 1.9 2 0 0 2 2 2 1 MIF4G domain MA3 PF02847.17 EMC85759.1 - 1.3e-28 99.3 0.5 6.7e-28 96.9 0.2 2.4 2 1 0 2 2 2 1 MA3 domain RPN1_RPN2_N PF17781.1 EMC85760.1 - 2.1e-112 375.5 2.1 2.1e-112 375.5 2.1 2.0 3 0 0 3 3 3 1 RPN1/RPN2 N-terminal domain PC_rep PF01851.22 EMC85760.1 - 3.5e-24 84.0 24.2 1.4e-06 28.4 0.1 8.8 10 0 0 10 10 10 5 Proteasome/cyclosome repeat RPN1_C PF18051.1 EMC85760.1 - 9.7e-22 76.8 1.0 2.1e-21 75.7 1.0 1.6 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal HEAT_2 PF13646.6 EMC85760.1 - 5.3e-05 23.5 0.0 0.11 12.9 0.0 4.0 4 1 1 5 5 5 2 HEAT repeats THAP PF05485.12 EMC85760.1 - 0.029 15.3 0.6 0.062 14.2 0.6 1.4 1 0 0 1 1 1 0 THAP domain Peptidase_M13_N PF05649.13 EMC85761.1 - 2.2e-122 409.5 0.7 3e-122 409.0 0.7 1.2 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 EMC85761.1 - 8.7e-74 247.6 0.1 1.8e-73 246.6 0.0 1.6 2 0 0 2 2 2 1 Peptidase family M13 Peptidase_M48 PF01435.18 EMC85761.1 - 0.2 11.4 0.0 0.43 10.3 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M48 ALG3 PF05208.13 EMC85764.1 - 1e-132 442.9 10.2 1.2e-132 442.7 10.2 1.0 1 0 0 1 1 1 1 ALG3 protein EpsG PF14897.6 EMC85764.1 - 0.0003 20.2 21.2 0.00047 19.6 20.7 1.4 1 1 0 1 1 1 1 EpsG family YqaJ PF09588.10 EMC85765.1 - 7.2e-16 58.7 0.0 1.1e-15 58.0 0.0 1.3 1 0 0 1 1 1 1 YqaJ-like viral recombinase domain Viral_alk_exo PF01771.17 EMC85765.1 - 1e-08 34.5 0.0 3.1e-08 32.9 0.0 1.7 2 0 0 2 2 2 1 Viral alkaline exonuclease DUF3551 PF12071.8 EMC85765.1 - 0.0027 17.7 0.5 0.0092 16.0 0.5 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3551) ABC_tran PF00005.27 EMC85766.1 - 3.6e-40 137.6 0.4 1.3e-19 71.0 0.0 3.0 3 0 0 3 3 3 2 ABC transporter ABC_tran_Xtn PF12848.7 EMC85766.1 - 1.5e-23 82.6 5.5 1.5e-23 82.6 5.5 2.8 3 1 0 3 3 1 1 ABC transporter AAA_21 PF13304.6 EMC85766.1 - 3.2e-11 43.6 4.0 0.0013 18.6 0.0 4.6 4 2 1 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EMC85766.1 - 1.3e-10 41.1 1.4 3.3e-05 23.4 0.0 4.0 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EMC85766.1 - 1.9e-07 31.2 3.6 0.0037 17.0 0.0 4.0 3 1 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 EMC85766.1 - 3.5e-06 27.3 0.6 0.025 14.9 0.0 3.2 3 1 0 3 3 2 2 AAA domain NACHT PF05729.12 EMC85766.1 - 1.2e-05 25.3 0.1 0.11 12.4 0.0 2.7 2 0 0 2 2 2 2 NACHT domain AAA PF00004.29 EMC85766.1 - 1.7e-05 25.2 0.3 0.3 11.5 0.0 3.4 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 EMC85766.1 - 4.3e-05 23.6 0.2 0.043 13.9 0.0 2.9 3 0 0 3 3 2 1 50S ribosome-binding GTPase AAA_29 PF13555.6 EMC85766.1 - 7.4e-05 22.4 0.1 0.052 13.3 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EMC85766.1 - 0.00011 22.1 0.0 0.19 11.6 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_24 PF13479.6 EMC85766.1 - 0.00024 20.9 0.0 0.98 9.1 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_28 PF13521.6 EMC85766.1 - 0.001 19.3 0.8 12 6.1 0.0 4.1 3 1 1 4 4 4 0 AAA domain AAA_16 PF13191.6 EMC85766.1 - 0.0014 19.0 1.8 0.79 10.1 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain Dynamin_N PF00350.23 EMC85766.1 - 0.0022 18.1 0.4 0.069 13.2 0.0 3.1 3 0 0 3 3 3 1 Dynamin family RNA_helicase PF00910.22 EMC85766.1 - 0.0024 18.2 0.0 0.58 10.6 0.0 2.8 2 0 0 2 2 2 1 RNA helicase NB-ARC PF00931.22 EMC85766.1 - 0.0034 16.6 0.0 0.49 9.5 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain Roc PF08477.13 EMC85766.1 - 0.0054 16.9 0.0 2 8.7 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_30 PF13604.6 EMC85766.1 - 0.0067 16.2 0.6 1.2 8.8 0.0 3.1 2 2 1 3 3 3 1 AAA domain AAA_23 PF13476.6 EMC85766.1 - 0.0095 16.5 15.4 0.38 11.2 0.0 4.0 4 1 1 5 5 4 2 AAA domain MobB PF03205.14 EMC85766.1 - 0.013 15.4 0.1 5.4 6.9 0.0 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B TsaE PF02367.17 EMC85766.1 - 0.016 15.2 0.0 11 6.1 0.0 2.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EMC85766.1 - 0.018 15.6 0.8 1.4 9.5 0.0 3.3 3 0 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 EMC85766.1 - 0.022 14.7 0.0 8.2 6.3 0.0 2.7 2 0 0 2 2 2 0 NTPase AAA_14 PF13173.6 EMC85766.1 - 0.023 14.8 0.9 3 7.9 0.0 3.4 3 1 1 4 4 3 0 AAA domain DUF87 PF01935.17 EMC85766.1 - 0.024 14.7 8.1 0.28 11.2 0.0 3.6 5 0 0 5 5 3 0 Helicase HerA, central domain Septin PF00735.18 EMC85766.1 - 0.025 13.9 0.0 4.7 6.4 0.0 2.3 2 0 0 2 2 2 0 Septin Arf PF00025.21 EMC85766.1 - 0.047 13.1 0.2 1.7 8.1 0.0 2.9 3 0 0 3 3 2 0 ADP-ribosylation factor family DUF1672 PF07901.11 EMC85766.1 - 0.06 12.7 1.3 0.1 11.9 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1672) PduV-EutP PF10662.9 EMC85766.1 - 0.071 12.9 0.1 8.9 6.1 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 EMC85766.1 - 0.072 12.6 0.0 4.8 6.6 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region MeaB PF03308.16 EMC85766.1 - 0.079 11.9 0.0 1.9 7.4 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 EMC85766.1 - 0.12 11.9 0.0 11 5.6 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.22 EMC85766.1 - 0.14 11.8 0.1 8.5 6.0 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_33 PF13671.6 EMC85766.1 - 0.53 10.4 5.5 3.1 8.0 0.0 3.2 4 0 0 4 4 2 0 AAA domain AAA_13 PF13166.6 EMC85766.1 - 7 5.2 9.4 3.2 6.3 0.1 3.4 2 2 1 4 4 4 0 AAA domain Adap_comp_sub PF00928.21 EMC85767.1 - 8.6e-82 274.5 0.1 1.1e-81 274.1 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EMC85767.1 - 0.00019 21.4 0.1 0.00069 19.6 0.1 1.8 2 0 0 2 2 2 1 Clathrin adaptor complex small chain muHD PF10291.9 EMC85767.1 - 0.024 14.1 0.0 0.042 13.3 0.0 1.3 1 0 0 1 1 1 0 Muniscin C-terminal mu homology domain Hexapep PF00132.24 EMC85768.1 - 5.5e-12 44.9 6.3 0.00013 21.5 1.1 4.0 2 1 2 4 4 4 4 Bacterial transferase hexapeptide (six repeats) W2 PF02020.18 EMC85768.1 - 3.3e-10 39.9 0.1 3.3e-10 39.9 0.1 2.8 3 0 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon DUF4954 PF16314.5 EMC85768.1 - 0.003 15.8 0.6 0.0051 15.0 0.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) DUF4007 PF13182.6 EMC85768.1 - 0.054 12.6 0.3 1.5 7.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4007) VIR_N PF15912.5 EMC85768.1 - 0.11 12.1 2.8 0.19 11.3 2.8 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal Hexapep_2 PF14602.6 EMC85768.1 - 5.6 6.8 11.6 1.9 8.3 5.6 3.2 2 1 1 3 3 3 0 Hexapeptide repeat of succinyl-transferase ABC_tran PF00005.27 EMC85769.1 - 6.9e-54 182.1 0.2 2.3e-31 109.1 0.0 3.3 3 0 0 3 3 3 2 ABC transporter ABC_membrane PF00664.23 EMC85769.1 - 7e-51 173.5 32.0 9.8e-34 117.2 9.1 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EMC85769.1 - 1.1e-11 44.6 6.0 0.008 15.6 0.0 4.4 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EMC85769.1 - 0.00021 21.2 9.8 3.7 7.3 0.3 4.3 2 2 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EMC85769.1 - 0.00029 20.5 1.3 0.43 10.4 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Dynamin_N PF00350.23 EMC85769.1 - 0.0012 19.0 0.8 0.044 13.8 0.0 2.9 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EMC85769.1 - 0.0015 18.6 2.6 0.86 9.7 0.3 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC85769.1 - 0.0052 16.7 0.8 0.25 11.2 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_7 PF12775.7 EMC85769.1 - 0.011 15.3 0.3 0.46 10.0 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_23 PF13476.6 EMC85769.1 - 0.011 16.2 7.7 0.16 12.5 0.1 3.4 3 0 0 3 3 3 0 AAA domain AAA_24 PF13479.6 EMC85769.1 - 0.021 14.6 0.2 0.44 10.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EMC85769.1 - 0.023 15.1 0.0 14 6.1 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.12 EMC85769.1 - 0.039 13.2 1.0 1.5 8.1 0.1 2.6 2 0 0 2 2 2 0 Zeta toxin DUF87 PF01935.17 EMC85769.1 - 0.048 13.7 1.4 2.4 8.2 0.4 2.7 2 0 0 2 2 2 0 Helicase HerA, central domain NB-ARC PF00931.22 EMC85769.1 - 0.07 12.3 0.9 3 7.0 0.0 2.8 3 0 0 3 3 3 0 NB-ARC domain TsaE PF02367.17 EMC85769.1 - 0.13 12.3 0.5 0.39 10.7 0.0 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.19 EMC85769.1 - 0.14 11.8 2.5 0.17 11.5 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 EMC85769.1 - 0.14 12.7 1.5 14 6.3 0.0 3.1 3 0 0 3 3 3 0 AAA domain LVIVD PF08309.11 EMC85769.1 - 0.16 11.3 0.1 0.41 10.0 0.1 1.6 1 0 0 1 1 1 0 LVIVD repeat IstB_IS21 PF01695.17 EMC85769.1 - 0.22 11.2 2.5 3.4 7.4 0.0 3.0 4 0 0 4 4 3 0 IstB-like ATP binding protein AAA_15 PF13175.6 EMC85769.1 - 3.9 7.1 8.7 6.8 6.3 0.3 3.1 3 0 0 3 3 3 0 AAA ATPase domain AAA_22 PF13401.6 EMC85769.1 - 8.7 6.6 10.7 27 5.0 0.9 4.1 2 2 1 3 3 3 0 AAA domain Peptidase_M1 PF01433.20 EMC85770.1 - 5.3e-40 137.3 0.0 1e-39 136.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 EMC85770.1 - 2.2e-28 98.6 0.1 4.5e-28 97.6 0.1 1.6 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 EMC85770.1 - 1.3e-10 41.8 0.2 2.7e-10 40.7 0.2 1.5 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain DUF2268 PF10026.9 EMC85770.1 - 0.0079 15.8 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 Predicted Zn-dependent protease (DUF2268) Peptidase_C2 PF00648.21 EMC85771.1 - 2.3e-80 269.8 0.0 3.2e-80 269.3 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 EMC85771.1 - 8.2e-44 149.3 0.0 1e-21 77.7 0.0 2.6 2 1 0 2 2 2 2 Calpain large subunit, domain III p450 PF00067.22 EMC85772.1 - 3.3e-121 405.3 0.0 3.8e-121 405.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 MCM6_C PF18263.1 EMC85772.1 - 0.17 12.1 0.0 0.36 11.1 0.0 1.4 1 0 0 1 1 1 0 MCM6 C-terminal winged-helix domain LRR_8 PF13855.6 EMC85773.1 - 8.2e-64 211.3 47.4 1.1e-14 53.9 2.6 5.9 2 1 4 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 EMC85773.1 - 1.2e-28 98.7 30.7 3.5e-08 33.6 0.2 7.1 5 1 2 7 7 7 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC85773.1 - 1.2e-21 77.0 0.0 6e-09 35.9 0.0 2.9 1 1 1 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC85773.1 - 5.6e-13 48.8 9.4 0.00034 20.2 0.3 4.8 1 1 3 5 5 5 5 Leucine-rich repeat LRR_1 PF00560.33 EMC85773.1 - 2.4e-05 24.3 27.9 0.24 12.1 0.1 9.0 8 2 1 9 9 9 2 Leucine Rich Repeat LRR_6 PF13516.6 EMC85773.1 - 0.081 13.0 26.0 0.53 10.5 0.0 8.3 9 0 0 9 9 9 0 Leucine Rich repeat Hairy_orange PF07527.13 EMC85774.1 - 2.3e-19 69.3 0.5 3.7e-19 68.6 0.5 1.3 1 0 0 1 1 1 1 Hairy Orange HLH PF00010.26 EMC85774.1 - 2e-05 24.4 0.1 3.3e-05 23.8 0.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain IL11 PF07400.11 EMC85774.1 - 0.18 11.5 0.1 0.37 10.4 0.1 1.5 1 1 0 1 1 1 0 Interleukin 11 Dynamin_N PF00350.23 EMC85775.1 - 1.7e-38 132.4 0.2 1.7e-38 132.4 0.2 3.2 5 0 0 5 5 5 1 Dynamin family MMR_HSR1 PF01926.23 EMC85775.1 - 1.1e-05 25.5 0.2 0.0002 21.4 0.0 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EMC85775.1 - 0.00017 21.1 0.0 0.011 15.2 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B Roc PF08477.13 EMC85775.1 - 0.0073 16.5 0.0 0.63 10.3 0.0 2.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase DUF1593 PF07632.11 EMC85775.1 - 0.013 14.9 0.1 0.013 14.9 0.1 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1593) AAA_16 PF13191.6 EMC85775.1 - 0.03 14.7 0.6 0.76 10.1 0.0 3.3 3 0 0 3 3 3 0 AAA ATPase domain Ras PF00071.22 EMC85775.1 - 0.042 13.5 1.0 8.4 6.0 0.0 2.8 3 0 0 3 3 3 0 Ras family DUF2267 PF10025.9 EMC85775.1 - 0.26 11.6 4.0 0.49 10.7 1.2 2.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2267) Ephrin_rec_like PF07699.13 EMC85775.1 - 0.27 11.0 0.3 0.62 9.9 0.3 1.6 1 0 0 1 1 1 0 Putative ephrin-receptor like NPV_P10 PF05531.12 EMC85775.1 - 0.67 10.5 7.1 0.3 11.6 0.8 3.3 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein PilO PF04350.13 EMC85775.1 - 1.3 9.2 8.9 3.1 7.9 0.0 3.4 3 0 0 3 3 3 0 Pilus assembly protein, PilO E1-E2_ATPase PF00122.20 EMC85776.1 - 2.3e-36 125.0 0.0 6.3e-36 123.6 0.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase P5-ATPase PF12409.8 EMC85776.1 - 1.7e-32 112.1 1.2 4.1e-32 110.9 1.2 1.7 1 0 0 1 1 1 1 P5-type ATPase cation transporter Hydrolase PF00702.26 EMC85776.1 - 4.7e-11 43.4 0.3 2.4e-08 34.5 0.1 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EMC85776.1 - 3.7e-07 29.7 0.0 1.1e-06 28.2 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EMC85776.1 - 0.00024 21.1 0.0 0.00068 19.7 0.0 1.8 2 0 0 2 2 2 1 Cation transport ATPase (P-type) DUF2620 PF10941.8 EMC85776.1 - 0.065 13.4 0.0 0.82 9.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function DUF2620 TcpE PF12648.7 EMC85776.1 - 0.99 10.0 7.9 0.16 12.5 2.3 2.5 2 0 0 2 2 2 0 TcpE family LRAT PF04970.13 EMC85777.1 - 2.5e-34 118.3 0.0 3.1e-34 118.0 0.0 1.1 1 0 0 1 1 1 1 Lecithin retinol acyltransferase NLPC_P60 PF00877.19 EMC85777.1 - 0.053 13.5 0.0 0.081 13.0 0.0 1.3 1 0 0 1 1 1 0 NlpC/P60 family Peptidase_C97 PF05903.14 EMC85777.1 - 0.075 12.9 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 PPPDE putative peptidase domain Calici_PP_N PF08405.11 EMC85777.1 - 0.084 11.7 0.0 0.12 11.2 0.0 1.3 1 1 0 1 1 1 0 Viral polyprotein N-terminal zf_CCCH_4 PF18345.1 EMC85778.1 - 1.1e-12 47.5 15.6 2.7e-06 27.2 5.7 2.5 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 EMC85778.1 - 8.8e-12 44.5 10.4 6.9e-10 38.5 2.6 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH PF00642.24 EMC85778.1 - 3.6e-10 39.5 7.6 7e-05 22.6 0.9 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EMC85778.1 - 9.8e-05 23.0 16.9 0.0002 22.0 0.6 3.7 2 1 1 3 3 3 2 Torus domain zf-CCCH_2 PF14608.6 EMC85778.1 - 0.041 14.4 11.6 0.96 10.0 1.6 2.6 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 EMC85778.1 - 0.29 11.4 7.7 6.9 6.9 0.8 2.1 1 1 0 1 1 1 0 Zinc-finger containing family ThiF PF00899.21 EMC85779.1 - 0.0022 17.4 0.1 0.0023 17.4 0.1 1.1 1 0 0 1 1 1 1 ThiF family Glyco_tranf_2_4 PF13704.6 EMC85780.1 - 5.7e-12 46.0 0.1 8.7e-12 45.4 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Aminotran_4 PF01063.19 EMC85780.1 - 0.015 15.1 0.0 0.017 15.0 0.0 1.2 1 0 0 1 1 1 0 Amino-transferase class IV Glyco_transf_92 PF01697.27 EMC85780.1 - 0.049 13.3 0.0 0.056 13.1 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 92 Sen15 PF09631.10 EMC85781.1 - 3.9e-26 91.3 0.0 6e-26 90.7 0.0 1.2 1 0 0 1 1 1 1 Sen15 protein DUF4612 PF15389.6 EMC85782.1 - 8.7e-44 149.2 6.9 9.8e-44 149.1 6.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4612) tRNA-synt_1e PF01406.19 EMC85782.1 - 0.0051 16.2 0.1 0.0057 16.1 0.1 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain RAWUL PF16207.5 EMC85785.1 - 6.3e-30 103.7 0.2 1.4e-29 102.6 0.2 1.6 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_2 PF13923.6 EMC85785.1 - 4.8e-16 58.3 10.3 8.1e-16 57.6 10.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC85785.1 - 5.6e-10 38.9 10.4 1e-09 38.1 10.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC85785.1 - 5.4e-09 36.2 8.5 9.2e-09 35.5 8.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EMC85785.1 - 6.2e-08 32.4 7.9 9.3e-08 31.8 7.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC85785.1 - 5.6e-06 26.3 8.0 1.1e-05 25.3 8.0 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMC85785.1 - 1.6e-05 24.7 8.5 3e-05 23.9 8.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EMC85785.1 - 4.9e-05 23.4 7.6 9.6e-05 22.5 7.6 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 EMC85785.1 - 0.00021 21.1 5.5 0.00036 20.3 5.5 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 EMC85785.1 - 0.00023 20.9 6.6 0.00048 19.8 6.6 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 EMC85785.1 - 0.001 18.9 3.7 0.0018 18.1 3.7 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 EMC85785.1 - 0.0015 18.7 7.1 0.0046 17.2 7.1 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_5 PF17121.5 EMC85785.1 - 0.035 14.0 7.1 0.34 10.8 7.4 2.2 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-UDP PF14569.6 EMC85785.1 - 0.042 13.9 1.9 0.14 12.3 1.9 1.9 1 0 0 1 1 1 0 Zinc-binding RING-finger Prok-RING_4 PF14447.6 EMC85785.1 - 0.066 13.1 8.4 0.9 9.4 8.8 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EMC85785.1 - 0.21 11.6 2.5 0.43 10.7 2.5 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 EMC85785.1 - 0.39 10.5 4.6 0.95 9.3 4.6 1.7 1 0 0 1 1 1 0 RING-like zinc finger zf-MIZ PF02891.20 EMC85785.1 - 0.76 9.6 6.8 1.5 8.7 6.8 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-C4_Topoisom PF01396.19 EMC85785.1 - 2.1 8.2 5.1 0.27 11.1 0.9 1.7 2 0 0 2 2 1 0 Topoisomerase DNA binding C4 zinc finger TRM PF02005.16 EMC85786.1 - 1e-69 235.6 5.4 1e-58 199.4 0.8 3.4 2 1 0 3 3 3 2 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 EMC85786.1 - 4.5e-05 23.3 0.4 0.0001 22.1 0.4 1.5 1 1 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 EMC85786.1 - 0.0012 18.5 0.1 0.0063 16.2 0.1 2.0 1 1 1 2 2 2 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 EMC85786.1 - 0.0066 17.1 0.2 0.55 11.0 0.0 3.3 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC85786.1 - 0.066 13.0 0.1 0.21 11.4 0.1 1.8 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 EMC85786.1 - 0.081 12.5 0.1 0.16 11.5 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase small domain zf-met PF12874.7 EMC85786.1 - 0.096 13.1 0.7 0.68 10.4 0.2 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Kelch_1 PF01344.25 EMC85787.1 - 6.6e-88 288.1 11.9 2.3e-15 55.9 0.1 6.6 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EMC85787.1 - 2.7e-49 163.9 2.4 2.4e-10 40.3 0.0 6.4 1 1 5 6 6 6 6 Kelch motif Kelch_3 PF13415.6 EMC85787.1 - 1e-39 134.1 9.0 1.6e-08 34.6 0.2 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.15 EMC85787.1 - 2.7e-37 125.3 1.3 7e-05 22.6 0.0 6.8 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 EMC85787.1 - 1.2e-34 118.1 2.1 9.4e-07 28.7 0.0 6.1 5 1 1 6 6 6 5 Galactose oxidase, central domain BTB PF00651.31 EMC85787.1 - 9.4e-27 93.5 0.5 1.4e-26 92.9 0.5 1.3 1 0 0 1 1 1 1 BTB/POZ domain Kelch_5 PF13854.6 EMC85787.1 - 5.8e-16 58.1 5.0 0.0014 18.6 0.0 6.1 6 0 0 6 6 6 4 Kelch motif BACK PF07707.15 EMC85787.1 - 3.8e-12 46.2 0.1 1.9e-11 44.0 0.0 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch XPA_C PF05181.12 EMC85787.1 - 0.073 13.1 1.9 38 4.3 0.0 4.3 5 0 0 5 5 5 0 XPA protein C-terminus PQQ_3 PF13570.6 EMC85787.1 - 0.12 12.9 7.5 2.2 8.9 0.1 4.7 5 0 0 5 5 5 0 PQQ-like domain ODR4-like PF14778.6 EMC85791.1 - 1.8e-119 399.0 1.4 2.6e-119 398.5 1.4 1.2 1 0 0 1 1 1 1 Olfactory receptor 4-like Phosducin PF02114.16 EMC85792.1 - 7.3e-20 71.0 3.1 8.1e-20 70.9 3.1 1.0 1 0 0 1 1 1 1 Phosducin tRNA_int_end_N2 PF12928.7 EMC85793.1 - 9.2e-05 22.5 10.7 10 6.4 0.4 5.8 1 1 5 6 6 6 6 tRNA-splicing endonuclease subunit sen54 N-term VCX_VCY PF15231.6 EMC85793.1 - 0.00021 22.0 0.0 3.8 8.2 0.0 2.9 1 1 2 3 3 3 3 Variable charge X/Y family EpCAM_N PF18635.1 EMC85793.1 - 0.0048 17.0 65.2 4.9 7.4 0.4 11.1 1 1 13 14 14 14 12 Epithelial cell adhesion molecule N-terminal domain DUF1513 PF07433.11 EMC85793.1 - 0.33 10.0 13.3 6.4 5.8 2.3 3.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1513) MIT PF04212.18 EMC85794.1 - 0.0023 18.0 0.0 0.0027 17.7 0.0 1.3 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Dpy-30 PF05186.13 EMC85795.1 - 3.6e-21 74.6 0.4 3.6e-21 74.6 0.4 1.5 2 0 0 2 2 2 1 Dpy-30 motif RIIa PF02197.17 EMC85795.1 - 0.0018 17.9 0.0 0.0035 17.0 0.0 1.5 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Memo PF01875.17 EMC85796.1 - 7.8e-75 251.5 0.0 9.2e-75 251.3 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein Glycolytic PF00274.19 EMC85796.1 - 0.071 11.8 0.1 0.1 11.3 0.1 1.2 1 0 0 1 1 1 0 Fructose-bisphosphate aldolase class-I Steroid_dh PF02544.16 EMC85797.1 - 1.1e-59 200.7 4.1 1.3e-59 200.5 4.1 1.0 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EMC85797.1 - 2.4e-06 27.3 0.1 3e-06 27.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 EMC85797.1 - 0.012 16.0 1.6 0.032 14.6 1.6 1.7 1 1 0 1 1 1 0 Phospholipid methyltransferase ELYS-bb PF16687.5 EMC85798.1 - 1.2e-299 993.8 0.0 1.5e-299 993.4 0.0 1.1 1 0 0 1 1 1 1 beta-propeller of ELYS nucleoporin ELYS PF13934.6 EMC85798.1 - 2.3e-56 191.3 0.5 4.3e-56 190.4 0.5 1.5 1 0 0 1 1 1 1 Nuclear pore complex assembly PapD_N PF00345.20 EMC85799.1 - 0.0012 18.7 0.6 0.58 10.1 0.1 2.3 2 0 0 2 2 2 2 Pili and flagellar-assembly chaperone, PapD N-terminal domain EVE PF01878.18 EMC85799.1 - 0.11 12.5 0.6 0.21 11.6 0.4 1.5 1 1 0 1 1 1 0 EVE domain U1snRNP70_N PF12220.8 EMC85799.1 - 0.82 10.3 5.9 0.85 10.3 2.0 2.4 2 1 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal V-set PF07686.17 EMC85800.1 - 1.8e-06 28.1 0.0 2.1e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC85800.1 - 0.068 13.8 0.0 0.14 12.8 0.0 1.5 1 1 0 1 1 1 0 Immunoglobulin domain Ras PF00071.22 EMC85801.1 - 2.2e-13 50.1 0.0 2.4e-13 50.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC85801.1 - 1.3e-07 31.9 0.0 1.4e-07 31.8 0.0 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PTPlike_phytase PF14566.6 EMC85802.1 - 7.8e-50 169.0 0.1 3.3e-41 141.0 0.0 2.5 2 0 0 2 2 2 2 Inositol hexakisphosphate Y_phosphatase PF00102.27 EMC85802.1 - 0.0054 16.3 0.0 0.11 12.0 0.0 2.3 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EMC85802.1 - 0.024 14.6 0.0 0.16 11.9 0.0 2.2 2 0 0 2 2 2 0 Tyrosine phosphatase family START PF01852.19 EMC85803.1 - 4.8e-24 84.9 0.2 6.2e-24 84.6 0.2 1.1 1 0 0 1 1 1 1 START domain Polyketide_cyc PF03364.20 EMC85803.1 - 8e-05 22.8 0.0 0.00019 21.6 0.0 1.6 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DUF3074 PF11274.8 EMC85803.1 - 0.034 14.1 0.0 0.12 12.4 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3074) Vitellogenin_N PF01347.22 EMC85804.1 - 1e-15 57.2 0.1 1.4e-15 56.8 0.1 1.1 1 0 0 1 1 1 1 Lipoprotein amino terminal region DUF1943 PF09172.11 EMC85804.1 - 6.8e-05 22.3 0.2 0.0003 20.2 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1943) HEAT_2 PF13646.6 EMC85804.1 - 0.14 12.6 1.1 0.38 11.2 0.1 2.2 2 0 0 2 2 2 0 HEAT repeats Pyridoxal_deC PF00282.19 EMC85805.1 - 2.1e-18 66.2 0.0 3.5e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EMC85805.1 - 1.2e-12 47.4 0.0 7.1e-12 45.0 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EMC85805.1 - 0.093 12.0 0.0 0.16 11.2 0.0 1.5 1 0 0 1 1 1 0 Beta-eliminating lyase Pterin_4a PF01329.19 EMC85806.1 - 7.3e-32 109.4 0.0 8.2e-32 109.2 0.0 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase UPA PF17217.3 EMC85808.1 - 2.7e-72 241.2 0.0 4.7e-72 240.4 0.0 1.4 1 0 0 1 1 1 1 UPA domain ZU5 PF00791.20 EMC85808.1 - 1.3e-30 105.6 0.0 3e-30 104.5 0.0 1.7 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 EMC85808.1 - 1.4e-15 57.2 0.2 3e-15 56.1 0.2 1.5 1 0 0 1 1 1 1 Death domain Ig_3 PF13927.6 EMC85808.1 - 5.2e-12 46.2 0.0 6.3e-08 33.1 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC85808.1 - 3.2e-11 43.2 0.0 1.8e-09 37.6 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin I-set domain TSP_1 PF00090.19 EMC85808.1 - 1e-10 41.7 27.5 2e-07 31.1 9.9 2.8 2 0 0 2 2 2 2 Thrombospondin type 1 domain ig PF00047.25 EMC85808.1 - 1.2e-06 28.6 1.0 2.2e-05 24.5 0.0 2.8 3 0 0 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.6 EMC85808.1 - 8.7e-06 26.0 0.0 0.00032 21.0 0.0 2.8 2 0 0 2 2 2 1 Immunoglobulin domain Nucleoside_tran PF01733.18 EMC85809.1 - 6e-68 229.5 8.2 6e-68 229.5 8.2 2.0 1 1 1 2 2 2 1 Nucleoside transporter MFS_1 PF07690.16 EMC85809.1 - 8.2e-05 21.7 35.4 0.00041 19.4 16.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Cadherin PF00028.17 EMC85812.1 - 0 1450.8 43.0 2.7e-21 75.8 0.1 28.1 27 1 0 27 27 27 27 Cadherin domain Cadherin_2 PF08266.12 EMC85812.1 - 4e-28 97.1 0.0 0.11 12.3 0.0 16.4 19 0 0 19 19 19 6 Cadherin-like Cadherin_3 PF16184.5 EMC85812.1 - 2.6e-26 91.8 36.9 0.0068 16.4 0.1 20.2 21 0 0 21 21 21 9 Cadherin-like RET_CLD1 PF17756.1 EMC85812.1 - 3.1e-11 43.7 0.0 2 8.7 0.0 9.4 10 0 0 10 10 10 2 RET Cadherin like domain 1 SusE PF14292.6 EMC85812.1 - 0.084 13.1 4.8 15 5.9 0.0 5.6 5 0 0 5 5 5 0 SusE outer membrane protein SapB_1 PF05184.15 EMC85813.1 - 6.5e-21 74.0 12.9 1e-11 44.6 3.8 2.6 2 0 0 2 2 2 2 Saposin-like type B, region 1 SapB_2 PF03489.17 EMC85813.1 - 1e-15 57.5 2.7 8.9e-10 38.5 0.5 3.2 2 0 0 2 2 2 2 Saposin-like type B, region 2 Helicase_C_3 PF13625.6 EMC85813.1 - 0.0058 16.8 0.0 0.02 15.1 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SapB_1 PF05184.15 EMC85814.1 - 2.8e-44 148.7 26.1 1.3e-13 50.7 0.9 5.9 5 0 0 5 5 5 4 Saposin-like type B, region 1 SapB_2 PF03489.17 EMC85814.1 - 3.5e-42 142.2 52.8 2.1e-12 46.9 3.0 6.1 8 0 0 8 8 8 4 Saposin-like type B, region 2 SapA PF02199.15 EMC85814.1 - 3.2e-16 59.3 9.5 3.2e-16 59.3 9.5 3.9 4 0 0 4 4 4 2 Saposin A-type domain TLE_N PF03920.15 EMC85814.1 - 0.016 15.3 6.6 0.067 13.3 0.9 3.1 3 1 0 3 3 3 0 Groucho/TLE N-terminal Q-rich domain TFCD_C PF12612.8 EMC85814.1 - 0.034 14.0 0.6 0.48 10.2 0.0 2.9 3 0 0 3 3 3 0 Tubulin folding cofactor D C terminal Sulfotransfer_1 PF00685.27 EMC85815.1 - 1e-39 136.6 0.0 1.2e-39 136.4 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC85815.1 - 8.4e-10 39.4 0.1 3e-09 37.6 0.0 1.8 2 0 0 2 2 2 1 Sulfotransferase family Pyr_redox_2 PF07992.14 EMC85816.1 - 9.6e-35 120.2 0.1 1.2e-34 119.9 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMC85816.1 - 6.1e-08 32.2 0.1 7.8e-06 25.3 0.0 2.1 1 1 1 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 EMC85816.1 - 8.1e-08 32.7 0.4 1.5e-07 31.9 0.4 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMC85816.1 - 1.7e-07 30.8 0.1 2.2e-07 30.4 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EMC85816.1 - 2.1e-06 27.8 0.7 0.23 11.4 0.1 3.2 3 0 0 3 3 3 2 FAD-NAD(P)-binding DAO PF01266.24 EMC85816.1 - 1.3e-05 25.0 0.8 0.014 15.0 0.1 2.8 2 1 1 3 3 3 2 FAD dependent oxidoreductase GIDA PF01134.22 EMC85816.1 - 0.00045 19.4 3.0 0.63 9.1 1.0 3.2 2 1 1 3 3 3 2 Glucose inhibited division protein A HI0933_like PF03486.14 EMC85816.1 - 0.0017 17.2 0.4 0.23 10.1 0.2 2.8 3 0 0 3 3 3 1 HI0933-like protein DUF4147 PF13660.6 EMC85816.1 - 0.0043 16.6 0.2 0.0069 15.9 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4147) Lycopene_cycl PF05834.12 EMC85816.1 - 0.016 14.2 0.6 0.044 12.8 0.2 1.9 3 0 0 3 3 3 0 Lycopene cyclase protein Trp_halogenase PF04820.14 EMC85816.1 - 0.02 13.8 1.7 0.57 9.0 0.4 2.3 2 0 0 2 2 2 0 Tryptophan halogenase Macro PF01661.21 EMC85817.1 - 4.7e-20 71.8 0.1 1.1e-19 70.6 0.1 1.7 1 1 0 1 1 1 1 Macro domain Histone_H2A_C PF16211.5 EMC85817.1 - 1.6e-16 59.7 0.6 1.6e-16 59.7 0.6 3.1 4 0 0 4 4 4 1 C-terminus of histone H2A Histone PF00125.24 EMC85817.1 - 6.8e-13 49.1 6.4 4.4e-12 46.5 0.0 2.3 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 RYDR_ITPR PF01365.21 EMC85817.1 - 0.0037 16.7 0.0 0.0072 15.8 0.0 1.4 1 0 0 1 1 1 1 RIH domain CBFD_NFYB_HMF PF00808.23 EMC85817.1 - 0.0066 16.7 0.0 0.017 15.4 0.0 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Clp_N PF02861.20 EMC85817.1 - 0.098 12.8 0.2 0.51 10.5 0.2 2.2 2 0 0 2 2 2 0 Clp amino terminal domain, pathogenicity island component DUF1764 PF08576.10 EMC85817.1 - 0.55 11.2 7.2 0.4 11.6 4.4 2.1 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Collagen PF01391.18 EMC85818.1 - 2.6e-20 72.0 73.4 2e-08 33.9 39.8 4.4 3 1 0 3 3 3 3 Collagen triple helix repeat (20 copies) Prefoldin PF02996.17 EMC85819.1 - 0.088 12.7 0.5 0.23 11.4 0.5 1.6 1 0 0 1 1 1 0 Prefoldin subunit DUF4407 PF14362.6 EMC85819.1 - 0.16 11.3 1.4 0.29 10.4 1.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2369 PF10179.9 EMC85820.1 - 1.7e-34 118.0 0.6 1.8e-31 108.4 0.1 3.4 3 0 0 3 3 3 2 Uncharacterised conserved protein (DUF2369) fn3 PF00041.21 EMC85820.1 - 5.9e-08 33.0 3.4 0.0012 19.2 0.1 4.5 5 0 0 5 5 5 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 EMC85820.1 - 0.00018 22.0 0.4 0.064 13.8 0.1 3.4 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain CopK PF11525.8 EMC85820.1 - 0.34 10.6 1.0 11 5.8 0.0 2.9 4 0 0 4 4 4 0 Copper resistance protein K Interfer-bind PF09294.10 EMC85820.1 - 6.7 7.1 7.2 3.5 8.0 0.0 3.9 6 0 0 6 6 6 0 Interferon-alpha/beta receptor, fibronectin type III KH_1 PF00013.29 EMC85822.1 - 2.5e-37 126.5 7.1 1.9e-15 56.4 0.4 5.7 5 0 0 5 5 5 3 KH domain SAM_1 PF00536.30 EMC85822.1 - 1.7e-14 54.0 0.1 3.5e-14 53.0 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC85822.1 - 1.8e-10 40.8 0.1 4.7e-10 39.4 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) KH_10 PF17905.1 EMC85822.1 - 7.7e-09 35.9 0.8 0.0024 18.2 0.2 3.7 3 1 0 3 3 3 2 GLD-3 KH domain 5 KH_2 PF07650.17 EMC85822.1 - 0.00028 20.7 0.1 0.12 12.2 0.2 2.7 2 0 0 2 2 2 2 KH domain SLS PF14611.6 EMC85822.1 - 0.00057 19.8 1.7 1.5 8.6 0.3 4.4 2 1 2 4 4 4 2 Mitochondrial inner-membrane-bound regulator IGR PF09597.10 EMC85822.1 - 0.17 12.0 0.0 0.43 10.7 0.0 1.6 1 0 0 1 1 1 0 IGR protein motif fn3 PF00041.21 EMC85823.1 - 1.7e-07 31.5 0.3 4.3e-07 30.2 0.1 1.8 2 1 0 2 2 2 1 Fibronectin type III domain fn3_4 PF16794.5 EMC85823.1 - 0.0093 15.9 0.2 0.017 15.0 0.2 1.4 1 0 0 1 1 1 1 Fibronectin-III type domain Drc1-Sld2 PF11719.8 EMC85824.1 - 0.16 11.5 19.7 0.023 14.2 2.2 3.2 2 1 0 3 3 3 0 DNA replication and checkpoint protein PilJ PF13675.6 EMC85824.1 - 1.8 8.6 4.2 36 4.4 0.1 3.0 3 0 0 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term TMF_DNA_bd PF12329.8 EMC85824.1 - 7.6 6.6 8.3 1.6 8.8 0.4 3.5 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding RhoGAP PF00620.27 EMC85825.1 - 7.8e-42 142.7 0.1 1e-41 142.3 0.1 1.1 1 0 0 1 1 1 1 RhoGAP domain VirB3 PF05101.13 EMC85825.1 - 0.035 14.3 0.4 0.06 13.6 0.0 1.6 2 0 0 2 2 2 0 Type IV secretory pathway, VirB3-like protein PAH PF02671.21 EMC85825.1 - 0.049 13.8 0.1 0.17 12.0 0.1 2.0 1 0 0 1 1 1 0 Paired amphipathic helix repeat Fanconi_A_N PF15865.5 EMC85825.1 - 0.055 12.9 0.2 0.073 12.5 0.2 1.1 1 0 0 1 1 1 0 Fanconi anaemia group A protein N terminus MFS_1 PF07690.16 EMC85826.1 - 6.3e-28 97.7 36.7 1.8e-16 60.1 13.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2046 PF09755.9 EMC85827.1 - 4e-120 400.7 50.0 4.6e-120 400.4 50.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) ATG16 PF08614.11 EMC85827.1 - 0.064 13.5 39.9 0.56 10.4 20.7 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) UPA_2 PF17809.1 EMC85828.1 - 1e-52 177.4 0.0 2e-52 176.4 0.0 1.5 1 0 0 1 1 1 1 UPA domain ZU5 PF00791.20 EMC85828.1 - 5.4e-33 113.3 0.9 5.6e-26 90.8 0.0 2.5 2 0 0 2 2 2 2 ZU5 domain Death PF00531.22 EMC85828.1 - 5.9e-21 74.4 0.5 1.5e-20 73.1 0.0 1.9 2 0 0 2 2 2 1 Death domain PYC_OADA PF02436.18 EMC85828.1 - 0.00063 19.5 2.5 0.003 17.3 0.3 2.9 3 0 0 3 3 3 1 Conserved carboxylase domain Pkinase PF00069.25 EMC85829.1 - 4.7e-77 258.9 0.0 5.4e-77 258.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC85829.1 - 1.2e-34 119.7 0.0 1.5e-34 119.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EMC85829.1 - 6.1e-06 25.4 0.0 1.1e-05 24.5 0.0 1.4 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EMC85829.1 - 0.0027 17.7 0.0 0.004 17.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EMC85829.1 - 0.003 16.9 0.0 0.005 16.2 0.0 1.5 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EMC85829.1 - 0.015 14.9 0.0 0.022 14.4 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 EMC85829.1 - 0.027 13.8 0.1 0.081 12.3 0.1 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EMC85829.1 - 0.065 12.3 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 BTB PF00651.31 EMC85830.1 - 2.9e-29 101.5 5.6 3.8e-17 62.5 0.1 3.9 4 0 0 4 4 4 3 BTB/POZ domain Ras PF00071.22 EMC85830.1 - 8.1e-24 84.1 0.0 1.8e-23 82.9 0.0 1.6 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EMC85830.1 - 2.6e-10 40.6 0.0 6.7e-10 39.2 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DUF1154 PF06631.11 EMC85830.1 - 0.39 10.8 2.2 1.3 9.1 2.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1154) BACK PF07707.15 EMC85830.1 - 0.82 9.8 4.0 1.9 8.7 0.2 3.0 3 1 0 3 3 3 0 BTB And C-terminal Kelch CLAMP PF14769.6 EMC85831.1 - 6.3e-21 74.7 0.1 1.2e-20 73.8 0.0 1.5 2 0 0 2 2 2 1 Flagellar C1a complex subunit C1a-32 Sad1_UNC PF07738.13 EMC85831.1 - 0.034 14.2 0.0 0.54 10.3 0.0 2.1 1 1 0 1 1 1 0 Sad1 / UNC-like C-terminal ARID PF01388.21 EMC85832.1 - 6.7e-17 61.9 0.0 1.6e-16 60.7 0.0 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Anillin PF08174.11 EMC85833.1 - 3.1e-46 157.3 0.1 6.2e-46 156.3 0.1 1.6 1 0 0 1 1 1 1 Cell division protein anillin PH PF00169.29 EMC85833.1 - 3e-10 40.5 0.3 1.2e-09 38.6 0.0 2.1 2 0 0 2 2 2 1 PH domain HR1 PF02185.16 EMC85833.1 - 0.0016 18.5 0.6 0.0049 17.0 0.6 1.9 1 0 0 1 1 1 1 Hr1 repeat PH_11 PF15413.6 EMC85833.1 - 0.0034 17.8 0.0 0.0096 16.3 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 EMC85833.1 - 0.01 16.2 0.0 0.05 14.0 0.0 2.0 1 1 0 1 1 1 0 Pleckstrin homology domain ERM PF00769.19 EMC85834.1 - 0.003 17.4 15.2 0.0041 17.0 15.2 1.2 1 0 0 1 1 1 1 Ezrin/radixin/moesin family RBD-FIP PF09457.10 EMC85834.1 - 0.0095 15.8 2.6 0.048 13.6 2.6 2.2 1 1 0 1 1 1 1 FIP domain PMC2NT PF08066.12 EMC85834.1 - 0.012 16.3 2.1 0.69 10.6 0.0 3.1 1 1 1 2 2 2 0 PMC2NT (NUC016) domain FUSC PF04632.12 EMC85834.1 - 0.015 13.9 6.0 0.019 13.5 6.0 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family VPS53_C PF16854.5 EMC85834.1 - 0.055 13.3 2.3 0.079 12.8 2.3 1.2 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 53 C-terminus Chal_sti_synt_N PF00195.19 EMC85834.1 - 0.057 12.8 1.7 0.082 12.3 0.9 1.6 1 1 1 2 2 2 0 Chalcone and stilbene synthases, N-terminal domain ZapB PF06005.12 EMC85834.1 - 0.18 12.3 17.4 0.15 12.5 4.4 2.5 1 1 1 2 2 2 0 Cell division protein ZapB DUF4094 PF13334.6 EMC85834.1 - 0.18 12.2 3.3 5.9 7.4 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) DUF641 PF04859.12 EMC85834.1 - 0.21 11.9 13.2 0.34 11.2 3.5 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) GrpE PF01025.19 EMC85834.1 - 0.21 11.2 16.8 0.059 13.0 9.4 2.1 1 1 1 2 2 2 0 GrpE V_ATPase_I PF01496.19 EMC85834.1 - 0.29 9.0 5.3 0.36 8.7 5.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Nipped-B_C PF12830.7 EMC85834.1 - 0.51 10.2 6.9 1.4 8.9 6.9 1.6 1 1 0 1 1 1 0 Sister chromatid cohesion C-terminus FapA PF03961.13 EMC85834.1 - 0.6 8.6 9.9 0.58 8.7 8.7 1.5 1 1 0 1 1 1 0 Flagellar Assembly Protein A Spc7 PF08317.11 EMC85834.1 - 1 8.2 16.9 1.5 7.6 16.9 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein ATP-synt_E_2 PF08112.11 EMC85834.1 - 1.1 9.6 4.6 8.5 6.7 0.2 2.8 2 1 0 2 2 2 0 ATP synthase epsilon subunit CENP-Q PF13094.6 EMC85834.1 - 1.3 9.2 18.0 45 4.2 17.9 2.2 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit COG2 PF06148.11 EMC85834.1 - 1.6 8.8 11.8 21 5.2 10.9 2.6 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 HBB PF06777.11 EMC85834.1 - 2.5 7.8 9.6 0.76 9.4 4.2 2.3 3 0 0 3 3 3 0 Helical and beta-bridge domain ALS2CR8 PF15299.6 EMC85834.1 - 2.5 7.9 8.7 2.2 8.1 2.6 2.3 1 1 1 2 2 2 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 dCache_2 PF08269.11 EMC85834.1 - 2.6 7.2 10.2 0.57 9.3 6.2 1.8 1 1 1 2 2 2 0 Cache domain Exonuc_VII_L PF02601.15 EMC85834.1 - 2.6 7.5 14.6 5.3 6.5 14.4 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit UPF0449 PF15136.6 EMC85834.1 - 3.3 8.2 8.8 9.6 6.7 3.7 2.7 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 DHR10 PF18595.1 EMC85834.1 - 3.7 7.7 24.2 0.57 10.3 15.4 2.4 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain LMBR1 PF04791.16 EMC85834.1 - 3.7 6.3 4.2 4.7 6.0 4.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein YabA PF06156.13 EMC85834.1 - 4.9 7.8 11.0 6.2 7.5 5.6 2.3 1 1 1 2 2 2 0 Initiation control protein YabA CDC37_N PF03234.14 EMC85834.1 - 8.8 7.3 9.8 77 4.2 9.9 2.3 1 1 0 1 1 1 0 Cdc37 N terminal kinase binding Fib_alpha PF08702.10 EMC85834.1 - 8.9 6.5 9.7 12 6.0 7.0 2.3 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family CENP-H PF05837.12 EMC85834.1 - 9.3 6.7 15.1 7.8 7.0 11.1 2.4 1 1 1 2 2 2 0 Centromere protein H (CENP-H) NRBF2 PF08961.10 EMC85835.1 - 1.4e-102 341.3 7.2 1.4e-102 341.3 7.2 1.4 2 0 0 2 2 2 1 Nuclear receptor-binding factor 2, autophagy regulator NRBF2_MIT PF17169.4 EMC85835.1 - 2.3e-45 152.7 11.1 2.3e-45 152.7 11.1 1.8 2 0 0 2 2 2 1 MIT domain of nuclear receptor-binding factor 2 DivIC PF04977.15 EMC85835.1 - 0.00078 19.2 2.4 0.00078 19.2 2.4 2.3 2 1 0 2 2 2 1 Septum formation initiator MIT PF04212.18 EMC85835.1 - 0.00099 19.1 6.1 0.0027 17.8 6.0 1.9 1 1 0 1 1 1 1 MIT (microtubule interacting and transport) domain YabA PF06156.13 EMC85835.1 - 0.002 18.7 1.1 0.002 18.7 1.1 2.2 2 0 0 2 2 2 1 Initiation control protein YabA PikAIV_N PF18605.1 EMC85835.1 - 0.0032 17.0 3.9 0.0067 16.0 3.9 1.6 1 0 0 1 1 1 1 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain HALZ PF02183.18 EMC85835.1 - 0.0063 16.7 1.9 0.018 15.3 1.9 1.8 1 0 0 1 1 1 1 Homeobox associated leucine zipper ZapB PF06005.12 EMC85835.1 - 0.0091 16.4 2.6 0.0091 16.4 2.6 2.5 2 1 0 2 2 1 1 Cell division protein ZapB TSC22 PF01166.18 EMC85835.1 - 0.031 14.6 0.7 0.084 13.2 0.7 1.7 1 0 0 1 1 1 0 TSC-22/dip/bun family DUF5101 PF17031.5 EMC85835.1 - 0.1 12.7 0.7 0.1 12.7 0.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5101) TPR_7 PF13176.6 EMC85835.1 - 0.11 12.6 0.1 0.3 11.2 0.1 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat JmjC PF02373.22 EMC85836.1 - 3.2e-11 43.7 0.0 1.8e-10 41.3 0.0 2.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-C5HC2 PF02928.16 EMC85836.1 - 0.023 15.1 4.4 0.062 13.7 4.4 1.8 1 0 0 1 1 1 0 C5HC2 zinc finger C1_2 PF03107.16 EMC85836.1 - 0.078 13.3 5.0 0.26 11.6 5.0 1.9 1 0 0 1 1 1 0 C1 domain FYVE PF01363.21 EMC85836.1 - 0.68 10.1 6.5 2.5 8.3 6.5 2.0 1 0 0 1 1 1 0 FYVE zinc finger zf-C2H2 PF00096.26 EMC85837.1 - 6.6e-08 32.6 18.1 0.0027 18.1 3.3 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC85837.1 - 1.5e-06 28.3 17.6 0.0049 17.2 0.3 5.7 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC85837.1 - 2.8e-05 24.6 17.4 0.025 15.4 2.7 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger Spt46 PF17734.1 EMC85837.1 - 0.017 14.9 1.1 0.068 13.0 0.1 2.0 2 0 0 2 2 2 0 Spermatogenesis-associated protein 46 Zn_ribbon_SprT PF17283.2 EMC85837.1 - 0.02 14.8 4.3 0.072 13.0 4.3 2.0 1 0 0 1 1 1 0 SprT-like zinc ribbon domain 7tm_4 PF13853.6 EMC85838.1 - 1.9e-27 96.7 4.3 2.1e-27 96.5 4.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC85838.1 - 1.3e-26 93.5 4.6 1.8e-26 93.0 4.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC85838.1 - 1.8e-05 24.3 3.7 2.1e-05 24.0 3.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC85838.1 - 0.00072 19.3 4.6 0.001 18.8 4.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 EMC85838.1 - 0.033 13.6 5.7 0.044 13.1 5.7 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv DUF2189 PF09955.9 EMC85838.1 - 0.12 12.7 4.2 4.5 7.5 0.1 2.2 2 0 0 2 2 2 0 Predicted integral membrane protein (DUF2189) WW_FCH_linker PF16623.5 EMC85839.1 - 6.7e-42 142.2 2.4 1.4e-41 141.1 2.4 1.6 1 0 0 1 1 1 1 Unstructured linker region between on GAS7 protein FCH PF00611.23 EMC85839.1 - 3.4e-15 56.1 4.2 5.2e-15 55.5 4.2 1.3 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain WW PF00397.26 EMC85839.1 - 3.6e-13 49.4 3.4 7.1e-13 48.4 3.4 1.5 1 0 0 1 1 1 1 WW domain Myosin_head PF00063.21 EMC85840.1 - 5e-286 950.4 3.2 5e-286 950.4 3.2 2.6 3 0 0 3 3 2 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 EMC85840.1 - 1.5e-94 317.8 154.4 1.8e-94 317.5 154.4 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.19 EMC85840.1 - 5.2e-14 51.8 3.3 1.4e-13 50.5 3.3 1.8 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain DUF1664 PF07889.12 EMC85840.1 - 0.00055 20.0 88.4 0.14 12.2 7.1 8.6 1 1 6 8 8 8 5 Protein of unknown function (DUF1664) DUF4537 PF15057.6 EMC85840.1 - 0.0031 17.5 0.3 0.024 14.7 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4537) Syntaxin-6_N PF09177.11 EMC85840.1 - 0.005 17.4 6.0 0.005 17.4 6.0 8.4 2 1 3 6 6 5 2 Syntaxin 6, N-terminal IQ PF00612.27 EMC85840.1 - 0.0066 16.1 0.2 0.039 13.8 0.0 2.3 2 0 0 2 2 2 1 IQ calmodulin-binding motif TMF_DNA_bd PF12329.8 EMC85840.1 - 0.0086 16.0 19.8 0.0086 16.0 19.8 11.0 4 2 4 10 10 10 1 TATA element modulatory factor 1 DNA binding ATG16 PF08614.11 EMC85840.1 - 0.072 13.3 140.8 4.5 7.4 26.5 6.6 1 1 3 5 5 5 0 Autophagy protein 16 (ATG16) AAA_22 PF13401.6 EMC85840.1 - 0.075 13.3 0.0 0.075 13.3 0.0 3.6 2 1 0 2 2 1 0 AAA domain ADIP PF11559.8 EMC85840.1 - 0.091 12.8 135.3 0.035 14.2 18.5 8.9 1 1 8 9 9 9 0 Afadin- and alpha -actinin-Binding ERM PF00769.19 EMC85840.1 - 0.16 11.8 161.1 0.21 11.3 30.8 6.3 1 1 3 5 5 5 0 Ezrin/radixin/moesin family AAA_16 PF13191.6 EMC85840.1 - 0.66 10.3 0.0 0.66 10.3 0.0 4.3 2 1 0 2 2 1 0 AAA ATPase domain Spc7 PF08317.11 EMC85840.1 - 1.5 7.6 143.6 0.092 11.6 17.9 6.2 1 1 5 6 6 6 0 Spc7 kinetochore protein Filament PF00038.21 EMC85840.1 - 1.7 8.2 129.1 0.53 9.8 15.0 6.2 1 1 3 4 4 4 0 Intermediate filament protein DUF3450 PF11932.8 EMC85840.1 - 2 7.6 117.0 0.17 11.2 9.9 7.1 2 2 5 7 7 7 0 Protein of unknown function (DUF3450) DUF3584 PF12128.8 EMC85840.1 - 4.2 4.8 129.9 0.35 8.3 41.9 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF3584) Acyltransferase PF01553.21 EMC85841.1 - 1.1e-08 34.7 0.0 1.8e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 EMC85841.1 - 2.9e-06 27.3 0.0 0.00054 20.0 0.0 2.4 1 1 1 2 2 2 2 Acyltransferase C-terminus IncFII_repA PF02387.15 EMC85841.1 - 0.058 12.6 0.4 0.09 12.0 0.4 1.3 1 0 0 1 1 1 0 IncFII RepA protein family Kringle PF00051.18 EMC85842.1 - 4.1e-147 478.8 68.4 3.7e-31 107.3 6.4 5.5 5 0 0 5 5 5 5 Kringle domain Trypsin PF00089.26 EMC85842.1 - 1.1e-46 159.4 0.0 2.3e-46 158.4 0.0 1.5 1 0 0 1 1 1 1 Trypsin PAN_1 PF00024.26 EMC85842.1 - 8.6e-09 35.2 1.5 3.4e-08 33.3 1.5 2.1 1 0 0 1 1 1 1 PAN domain DUF1986 PF09342.11 EMC85842.1 - 9.8e-09 35.6 0.1 1.8e-08 34.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) DUF3719 PF12516.8 EMC85842.1 - 4.7 7.0 8.9 94 2.8 0.1 4.9 5 0 0 5 5 5 0 Protein of unknown function (DUF3719) Kringle PF00051.18 EMC85843.1 - 6.9e-150 487.7 72.8 7.9e-31 106.2 8.6 5.4 5 0 0 5 5 5 5 Kringle domain Trypsin PF00089.26 EMC85843.1 - 2.3e-63 214.0 0.1 3.7e-63 213.3 0.1 1.4 1 0 0 1 1 1 1 Trypsin PAN_1 PF00024.26 EMC85843.1 - 9.7e-11 41.5 1.3 9.7e-11 41.5 1.3 2.4 2 0 0 2 2 2 1 PAN domain Trypsin_2 PF13365.6 EMC85843.1 - 1.8e-09 38.6 0.0 3.5e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 EMC85843.1 - 2.2e-08 34.5 0.0 4.1e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) KduI PF04962.12 EMC85843.1 - 0.58 9.4 7.3 3.7 6.8 0.0 3.2 3 0 0 3 3 3 0 KduI/IolB family Sugar_tr PF00083.24 EMC85844.1 - 1.1e-29 103.6 13.4 1.1e-29 103.6 13.4 1.9 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 EMC85844.1 - 4e-28 98.3 34.5 8.5e-22 77.5 15.3 2.4 2 1 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMC85845.1 - 2.3e-29 102.6 9.0 4e-29 101.8 9.0 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMC85845.1 - 3.7e-19 68.9 27.5 1.2e-14 54.1 10.0 2.5 2 1 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMC85846.1 - 1.4e-33 116.5 12.3 2.5e-33 115.6 12.3 1.4 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMC85846.1 - 2.5e-27 95.8 30.2 4.7e-25 88.3 17.0 2.4 2 1 1 3 3 3 2 Major Facilitator Superfamily CIMR PF00878.18 EMC85847.1 - 0 1217.0 88.5 8.7e-52 175.0 2.5 15.2 15 0 0 15 15 15 15 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.10 EMC85847.1 - 8.8e-63 212.6 91.6 6.5e-09 36.0 0.2 16.0 3 2 12 15 15 15 13 Autophagy-related protein 27 Man-6-P_recep PF02157.15 EMC85847.1 - 3.6e-53 180.3 31.8 1.6e-09 37.3 1.0 13.6 7 3 6 14 14 14 11 Mannose-6-phosphate receptor fn2 PF00040.19 EMC85847.1 - 5.5e-18 64.9 7.2 2.7e-17 62.7 7.2 2.4 1 0 0 1 1 1 1 Fibronectin type II domain PRKCSH_1 PF13015.6 EMC85847.1 - 1e-05 25.3 49.2 0.011 15.5 0.3 10.8 12 1 1 13 13 13 5 Glucosidase II beta subunit-like protein DUF4448 PF14610.6 EMC85847.1 - 0.00056 19.7 0.8 8.8 6.1 0.0 3.6 3 0 0 3 3 3 2 Protein of unknown function (DUF4448) 7tm_1 PF00001.21 EMC85848.1 - 5.7e-18 65.2 27.5 1.2e-17 64.2 27.5 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC85848.1 - 3.7e-09 36.6 22.2 3.7e-09 36.6 22.2 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx ISK_Channel PF02060.15 EMC85848.1 - 0.1 12.4 1.9 0.63 9.8 0.0 2.6 2 1 1 3 3 3 0 Slow voltage-gated potassium channel PEN-2 PF10251.9 EMC85848.1 - 6.6 7.2 9.4 2.3 8.7 0.2 3.4 2 1 1 3 3 3 0 Presenilin enhancer-2 subunit of gamma secretase Serpentine_r_xa PF03383.15 EMC85848.1 - 9.1 6.2 29.0 0.025 14.6 15.0 2.8 2 1 1 3 3 3 0 Caenorhabditis serpentine receptor-like protein, class xa CAF1 PF04857.20 EMC85849.1 - 4e-69 233.2 0.1 5e-69 232.9 0.1 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease Thiolase_N PF00108.23 EMC85850.1 - 9.3e-82 274.3 2.0 1.3e-81 273.8 2.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EMC85850.1 - 4.2e-50 168.5 0.6 8.2e-50 167.6 0.6 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EMC85850.1 - 0.00013 21.6 2.8 0.00015 21.5 0.5 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Dodecin PF07311.12 EMC85850.1 - 0.0042 17.3 0.1 0.01 16.0 0.1 1.6 1 0 0 1 1 1 1 Dodecin ACP_syn_III_C PF08541.10 EMC85850.1 - 0.0043 17.2 0.1 0.012 15.8 0.1 1.8 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Wtap PF17098.5 EMC85851.1 - 1.4e-61 207.0 13.7 1.4e-61 207.0 13.7 2.4 2 1 0 2 2 2 1 WTAP/Mum2p family Atg14 PF10186.9 EMC85851.1 - 0.026 13.6 21.7 0.09 11.8 5.3 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 ADIP PF11559.8 EMC85851.1 - 0.056 13.5 33.5 0.31 11.1 9.1 3.6 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding PRKG1_interact PF15898.5 EMC85851.1 - 2.8 8.9 28.1 1 10.3 1.2 3.7 3 1 0 3 3 3 0 cGMP-dependent protein kinase interacting domain DUF2000 PF09391.10 EMC85851.1 - 3.3 7.6 4.5 1.1 9.2 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2000) SPACA9 PF15120.6 EMC85851.1 - 3.6 7.3 18.0 0.038 13.8 5.5 2.3 2 0 0 2 2 2 0 Sperm acrosome-associated protein 9 DUF2120 PF09893.9 EMC85851.1 - 4.7 7.3 7.1 1.8 8.7 0.1 2.9 2 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2120) Spc7 PF08317.11 EMC85851.1 - 6.7 5.5 33.3 7.4 5.4 13.2 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Sod_Fe_C PF02777.18 EMC85852.1 - 8.2e-39 131.9 0.0 1.5e-38 131.1 0.0 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EMC85852.1 - 9.5e-32 109.3 1.7 1.5e-31 108.7 1.7 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain fn3 PF00041.21 EMC85853.1 - 7.3e-33 112.8 4.6 3.1e-10 40.3 0.0 4.9 5 0 0 5 5 5 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 EMC85853.1 - 2.6e-07 31.1 2.5 0.0025 18.3 0.2 5.5 6 0 0 6 6 6 3 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 EMC85853.1 - 2.1e-06 28.0 0.0 0.2 12.0 0.2 3.8 3 0 0 3 3 3 2 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.9 EMC85853.1 - 0.0021 18.4 0.0 2.2 8.7 0.0 4.0 3 0 0 3 3 3 1 Uncharacterised conserved protein (DUF2369) SF3b10 PF07189.11 EMC85854.1 - 2e-39 133.5 0.1 2.2e-39 133.4 0.1 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) DUF2264 PF10022.9 EMC85854.1 - 0.016 14.3 0.2 0.017 14.2 0.2 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2264) Syntaxin PF00804.25 EMC85855.1 - 1.1e-63 214.6 14.8 1.7e-63 213.9 14.8 1.3 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.19 EMC85855.1 - 8.7e-06 25.6 2.8 1.2e-05 25.2 0.1 2.5 3 0 0 3 3 3 1 SNARE domain Herpes_BLRF2 PF05812.12 EMC85855.1 - 0.0059 16.7 2.4 0.017 15.2 0.9 2.2 1 1 1 2 2 2 1 Herpesvirus BLRF2 protein DUF1217 PF06748.12 EMC85855.1 - 0.076 13.1 0.2 0.17 11.9 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1217) Spectrin PF00435.21 EMC85855.1 - 0.15 12.5 8.1 0.14 12.6 1.9 2.7 2 1 0 2 2 2 0 Spectrin repeat Toprim_Crpt PF13342.6 EMC85855.1 - 0.16 12.0 0.0 0.36 10.8 0.0 1.6 1 0 0 1 1 1 0 C-terminal repeat of topoisomerase HisKA_3 PF07730.13 EMC85855.1 - 0.22 12.1 2.8 3.1 8.4 0.3 3.4 2 2 2 4 4 4 0 Histidine kinase TMF_DNA_bd PF12329.8 EMC85855.1 - 0.3 11.1 2.9 0.45 10.5 0.2 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.15 EMC85855.1 - 0.33 10.8 5.4 0.15 11.8 0.5 2.7 3 0 0 3 3 3 0 Septum formation initiator SKA2 PF16740.5 EMC85855.1 - 0.73 9.6 5.2 0.54 10.1 0.2 2.7 3 1 0 3 3 3 0 Spindle and kinetochore-associated protein 2 FlaC_arch PF05377.11 EMC85855.1 - 0.88 10.0 7.0 1.8 9.0 0.1 3.8 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) CENP-H PF05837.12 EMC85855.1 - 1.1 9.7 6.5 0.52 10.7 0.9 2.4 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Occludin_ELL PF07303.13 EMC85855.1 - 1.8 9.3 6.9 2.1 9.1 1.5 2.6 3 0 0 3 3 3 0 Occludin homology domain Fez1 PF06818.15 EMC85855.1 - 7.9 6.9 11.8 14 6.1 3.8 2.4 1 1 0 2 2 2 0 Fez1 DSPc PF00782.20 EMC85856.1 - 1.2e-13 51.0 0.0 2.3e-13 50.1 0.0 1.5 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase2 PF03162.13 EMC85856.1 - 0.027 14.0 0.0 0.069 12.7 0.0 1.7 2 0 0 2 2 2 0 Tyrosine phosphatase family AAA_25 PF13481.6 EMC85856.1 - 0.039 13.5 0.0 0.054 13.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain CDKN3 PF05706.12 EMC85856.1 - 0.076 12.7 0.0 0.12 12.0 0.0 1.4 1 1 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) F-box_4 PF15966.5 EMC85857.1 - 2.3e-50 169.3 0.7 2.3e-50 169.3 0.7 2.2 2 0 0 2 2 2 1 F-box zf-TRAF_2 PF15965.5 EMC85857.1 - 2.1e-38 130.7 15.0 2.1e-38 130.7 15.0 2.9 3 1 0 3 3 3 1 TRAF-like zinc-finger F-box PF00646.33 EMC85857.1 - 2.2e-07 30.6 0.8 5.9e-07 29.2 0.8 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EMC85857.1 - 2.1e-06 27.5 0.2 6.1e-06 26.0 0.2 1.8 1 0 0 1 1 1 1 F-box-like zf-TRAF PF02176.18 EMC85857.1 - 0.0043 17.7 1.9 0.0043 17.7 1.9 4.4 6 0 0 6 6 6 1 TRAF-type zinc finger DUF4644 PF15486.6 EMC85857.1 - 0.033 13.9 0.8 4.3 7.1 0.1 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4644) zf-C2H2_4 PF13894.6 EMC85857.1 - 2.5 9.2 7.5 28 5.9 0.4 4.2 3 0 0 3 3 3 0 C2H2-type zinc finger ANF_receptor PF01094.28 EMC85858.1 - 2.3e-94 316.4 0.0 3.5e-94 315.8 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.22 EMC85858.1 - 1.1e-56 192.2 27.5 1.6e-56 191.7 27.5 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR GluR_Homer-bdg PF10606.9 EMC85858.1 - 3.7e-25 87.9 9.4 1.1e-24 86.4 9.4 1.9 1 0 0 1 1 1 1 Homer-binding domain of metabotropic glutamate receptor NCD3G PF07562.14 EMC85858.1 - 2.3e-15 56.3 10.4 4.8e-15 55.3 10.4 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR DUF5438 PF17506.2 EMC85858.1 - 0.058 13.7 0.4 0.21 11.9 0.4 2.0 1 0 0 1 1 1 0 Family of unknown function (DUF5438) AAA_34 PF13872.6 EMC85858.1 - 0.16 10.8 0.0 0.25 10.2 0.0 1.2 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 Ras PF00071.22 EMC85859.1 - 1.2e-41 142.0 0.0 1.4e-41 141.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC85859.1 - 9.1e-28 96.9 0.0 1.2e-27 96.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC85859.1 - 2.6e-09 36.8 0.0 3.1e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EMC85859.1 - 5.5e-06 25.9 0.0 6.7e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMC85859.1 - 0.00045 20.3 0.0 0.00061 19.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EMC85859.1 - 0.00061 20.1 0.0 0.0053 17.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EMC85859.1 - 0.0022 17.5 0.0 0.0034 16.9 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region GTP_EFTU PF00009.27 EMC85859.1 - 0.0034 17.0 0.0 0.098 12.2 0.0 2.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 EMC85859.1 - 0.0063 16.3 0.0 0.15 11.8 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 EMC85859.1 - 0.013 15.3 0.0 2.9 7.6 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 EMC85859.1 - 0.065 13.6 0.0 0.11 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain TniB PF05621.11 EMC85859.1 - 0.068 12.6 0.0 0.31 10.4 0.0 1.8 1 1 1 2 2 2 0 Bacterial TniB protein TsaE PF02367.17 EMC85859.1 - 0.08 13.0 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 EMC85859.1 - 0.11 11.6 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 EMC85859.1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain DLIC PF05783.11 EMC85859.1 - 0.13 11.0 0.0 2.7 6.7 0.1 2.0 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) AAA PF00004.29 EMC85859.1 - 0.2 12.1 0.0 0.29 11.6 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Peptidase_C2 PF00648.21 EMC85860.1 - 2.5e-10 39.9 0.0 1.2e-08 34.4 0.0 2.2 2 0 0 2 2 2 2 Calpain family cysteine protease Globin PF00042.22 EMC85861.1 - 2e-05 25.1 0.0 0.00061 20.3 0.0 2.3 2 0 0 2 2 2 1 Globin IQ PF00612.27 EMC85861.1 - 0.04 13.7 0.1 0.083 12.7 0.1 1.6 1 0 0 1 1 1 0 IQ calmodulin-binding motif SAM_1 PF00536.30 EMC85862.1 - 7.6e-08 32.7 0.0 8.8e-08 32.5 0.0 1.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC85862.1 - 1.4e-06 28.3 0.0 1.5e-06 28.2 0.0 1.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) NCD1 PF04904.13 EMC85862.1 - 0.0018 18.2 0.1 0.0021 18.0 0.1 1.0 1 0 0 1 1 1 1 NAB conserved region 1 (NCD1) SLY PF12485.8 EMC85863.1 - 3.8e-42 144.6 13.3 3.8e-42 144.6 13.3 3.5 3 1 2 5 5 5 1 Lymphocyte signaling adaptor protein SAM_2 PF07647.17 EMC85863.1 - 4.5e-18 65.1 0.0 1.1e-07 31.9 0.0 2.6 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EMC85863.1 - 1.5e-16 60.5 0.0 5.9e-08 33.0 0.0 2.7 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SH3_2 PF07653.17 EMC85863.1 - 9.3e-06 25.2 0.0 2.7e-05 23.8 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EMC85863.1 - 0.0092 15.6 0.0 0.019 14.6 0.0 1.6 1 0 0 1 1 1 1 SH3 domain Sulfotransfer_2 PF03567.14 EMC85864.1 - 2.7e-32 112.7 1.1 3.5e-32 112.3 1.1 1.1 1 0 0 1 1 1 1 Sulfotransferase family Gal-3-0_sulfotr PF06990.11 EMC85864.1 - 2.5e-08 33.2 0.3 3.4e-08 32.8 0.3 1.2 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase CUE PF02845.16 EMC85865.1 - 1.8e-09 37.1 0.1 3.2e-09 36.3 0.1 1.4 1 0 0 1 1 1 1 CUE domain zf-RanBP PF00641.18 EMC85865.1 - 1.4e-05 24.3 2.0 3.3e-05 23.1 2.0 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Spc29 PF17082.5 EMC85865.1 - 0.0013 18.7 1.3 0.0035 17.2 1.3 1.7 1 0 0 1 1 1 1 Spindle Pole Component 29 DivIC PF04977.15 EMC85865.1 - 0.018 14.8 2.9 0.16 11.7 2.4 2.2 2 0 0 2 2 2 0 Septum formation initiator Spc7 PF08317.11 EMC85865.1 - 0.048 12.5 4.0 0.073 11.9 4.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein XhlA PF10779.9 EMC85865.1 - 0.95 9.7 4.3 1.7 8.9 4.3 1.3 1 0 0 1 1 1 0 Haemolysin XhlA SlyX PF04102.12 EMC85865.1 - 1.6 9.4 5.2 1.8 9.2 3.3 2.1 1 1 1 2 2 2 0 SlyX Regnase_1_C PF18561.1 EMC85866.1 - 0.005 16.6 0.0 0.014 15.1 0.0 1.8 1 0 0 1 1 1 1 Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain RNase_Zc3h12a PF11977.8 EMC85867.1 - 2e-55 186.8 0.0 3.2e-55 186.2 0.0 1.2 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain UBA_6 PF18039.1 EMC85867.1 - 2.9e-21 75.1 0.2 5e-21 74.3 0.2 1.4 1 0 0 1 1 1 1 UBA-like domain zf-CCCH_4 PF18044.1 EMC85867.1 - 8.5e-05 22.3 6.3 8.5e-05 22.3 6.3 2.4 3 0 0 3 3 3 1 CCCH-type zinc finger zf-CCCH PF00642.24 EMC85867.1 - 0.2 11.6 7.7 1.8 8.6 7.7 2.5 1 1 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 EMC85867.1 - 0.52 10.9 8.1 1.6 9.3 8.1 1.9 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Omega-toxin PF06357.11 EMC85867.1 - 0.89 9.4 4.7 2.3 8.1 4.7 1.6 1 0 0 1 1 1 0 Omega-atracotoxin zf_CCCH_4 PF18345.1 EMC85867.1 - 4.2 7.6 8.7 1.6 8.9 4.6 2.5 2 1 1 3 3 3 0 Zinc finger domain Pro_isomerase PF00160.21 EMC85868.1 - 1.7e-37 129.2 0.1 4.1e-37 127.9 0.1 1.7 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 EMC85868.1 - 6.1e-18 64.4 0.0 1.2e-17 63.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.25 EMC85870.1 - 4.4e-62 209.8 0.7 1.5e-39 136.0 0.0 3.1 4 0 0 4 4 4 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMC85870.1 - 2.6e-28 99.0 0.0 5.3e-20 71.8 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase UBA PF00627.31 EMC85870.1 - 2.1e-10 40.3 0.8 2.1e-10 40.3 0.8 2.2 2 0 0 2 2 2 1 UBA/TS-N domain Haspin_kinase PF12330.8 EMC85870.1 - 0.00064 18.8 0.1 0.0012 17.9 0.1 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EMC85870.1 - 0.0033 16.8 0.1 0.024 13.9 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EMC85870.1 - 0.0038 17.2 0.5 0.024 14.6 0.4 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family UBA_3 PF09288.10 EMC85870.1 - 0.05 13.4 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain Pkinase_C PF00433.24 EMC85870.1 - 0.056 14.2 1.1 0.39 11.5 1.1 2.5 1 0 0 1 1 1 0 Protein kinase C terminal domain Pox_ser-thr_kin PF05445.11 EMC85870.1 - 0.11 11.5 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase HOIP-UBA PF16678.5 EMC85870.1 - 0.14 12.2 0.6 0.81 9.7 0.0 2.1 2 0 0 2 2 2 0 HOIP UBA domain pair Cas_Cas6 PF01881.16 EMC85870.1 - 0.14 12.7 1.4 0.26 11.8 1.4 1.3 1 0 0 1 1 1 0 CRISPR associated protein Cas6 PCMT PF01135.19 EMC85871.1 - 4.7e-76 255.2 0.0 5.3e-76 255.0 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 EMC85871.1 - 7.4e-07 29.8 0.0 1.2e-06 29.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC85871.1 - 9.9e-07 28.7 0.0 2.1e-06 27.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC85871.1 - 7.6e-05 23.3 0.0 0.00021 21.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.10 EMC85871.1 - 0.00011 21.9 0.0 0.00013 21.7 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Ubie_methyltran PF01209.18 EMC85871.1 - 0.00012 21.5 0.0 0.00016 21.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.13 EMC85871.1 - 0.00012 21.5 0.0 0.00014 21.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 EMC85871.1 - 0.0015 18.4 0.0 0.0038 17.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EMC85871.1 - 0.026 14.1 0.1 0.04 13.5 0.1 1.4 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_32 PF13679.6 EMC85871.1 - 0.068 13.1 0.0 0.098 12.6 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain Fibrillarin PF01269.17 EMC85871.1 - 0.09 11.9 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Fibrillarin FtsJ PF01728.19 EMC85871.1 - 0.13 12.3 0.0 0.23 11.6 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_16 PF10294.9 EMC85871.1 - 0.17 11.6 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Ldl_recept_a PF00057.18 EMC85872.1 - 2e-07 31.1 11.2 4.1e-07 30.1 11.2 1.5 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A DUF4625 PF15418.6 EMC85872.1 - 0.042 14.1 0.1 0.093 13.0 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4625) PP1_inhibitor PF05361.12 EMC85873.1 - 4.3e-15 56.0 0.2 4.4e-15 55.9 0.2 1.0 1 0 0 1 1 1 1 PKC-activated protein phosphatase-1 inhibitor Nitroreductase PF00881.24 EMC85874.1 - 1.1e-19 71.1 0.0 1.7e-19 70.5 0.0 1.2 1 0 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 EMC85874.1 - 0.0012 18.4 0.0 4.7 6.7 0.0 3.1 2 1 1 3 3 3 3 Putative TM nitroreductase RhoGEF PF00621.20 EMC85875.1 - 1.2e-44 152.7 1.8 1.2e-44 152.7 1.8 2.2 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 EMC85875.1 - 0.00014 22.3 0.2 0.00059 20.3 0.1 2.2 1 1 0 1 1 1 1 PH domain NOG1_N PF17835.1 EMC85875.1 - 0.016 15.1 0.2 2 8.4 0.1 2.8 2 0 0 2 2 2 0 NOG1 N-terminal helical domain PH_10 PF15411.6 EMC85875.1 - 0.017 15.4 0.1 0.017 15.4 0.1 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 EMC85875.1 - 0.078 12.9 0.2 0.27 11.2 0.2 1.9 1 0 0 1 1 1 0 PH domain PH_16 PF17838.1 EMC85875.1 - 0.088 12.7 1.2 0.58 10.0 0.6 2.6 2 1 0 2 2 2 0 PH domain SICA_alpha PF12887.7 EMC85875.1 - 0.095 12.6 0.1 0.24 11.2 0.1 1.6 1 0 0 1 1 1 0 SICA extracellular alpha domain Syntaxin_2 PF14523.6 EMC85875.1 - 4.4 7.7 9.0 0.58 10.6 0.1 3.4 3 0 0 3 3 3 0 Syntaxin-like protein FTHFS PF01268.19 EMC85876.1 - 2.3e-239 795.3 0.7 2.7e-239 795.0 0.7 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 EMC85876.1 - 6e-24 84.2 0.2 3.9e-23 81.5 0.0 2.3 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 EMC85876.1 - 5.7e-17 62.1 0.1 1.3e-16 60.9 0.1 1.7 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Alba PF01918.21 EMC85876.1 - 0.049 13.5 0.0 0.16 11.8 0.0 1.9 1 0 0 1 1 1 0 Alba WSK PF03832.13 EMC85877.1 - 3.1e-23 81.2 21.6 1.2e-12 47.3 2.3 6.0 7 0 0 7 7 7 3 WSK motif BTB PF00651.31 EMC85878.1 - 4.2e-19 68.8 0.2 9e-19 67.8 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.26 EMC85878.1 - 3.2e-14 52.5 30.2 0.00023 21.5 1.5 4.8 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC85878.1 - 2.9e-12 46.4 19.9 0.00013 22.3 2.9 5.4 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC85878.1 - 3.2e-09 36.8 27.2 0.012 16.4 1.3 5.1 5 0 0 5 5 4 3 C2H2-type zinc finger zf-met PF12874.7 EMC85878.1 - 1.1e-08 35.2 21.9 0.16 12.4 1.5 4.8 4 0 0 4 4 4 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMC85878.1 - 5.8e-07 29.6 16.6 0.014 15.7 0.1 4.7 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-C2H2_3rep PF18868.1 EMC85878.1 - 8e-05 23.3 8.6 0.22 12.2 0.0 4.0 2 1 2 4 4 4 2 Zinc finger C2H2-type, 3 repeats zf-C2HE PF16278.5 EMC85878.1 - 0.036 14.5 15.9 6.2 7.3 0.1 4.5 3 1 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_6 PF13912.6 EMC85878.1 - 0.037 14.0 30.5 0.74 9.9 0.5 4.8 4 1 0 4 4 4 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 EMC85878.1 - 0.099 12.6 19.0 0.36 10.8 0.4 4.3 4 0 0 4 4 4 0 zinc-finger of a C2HC-type FYVE PF01363.21 EMC85878.1 - 0.18 12.0 16.5 5.9 7.1 0.0 3.9 3 1 0 3 3 3 0 FYVE zinc finger zf-C2H2_2 PF12756.7 EMC85878.1 - 0.24 11.8 17.5 4.1 7.8 0.3 3.5 2 1 0 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-AN1 PF01428.16 EMC85878.1 - 1.3 9.3 21.7 0.31 11.2 2.7 4.7 4 1 0 4 4 4 0 AN1-like Zinc finger Zn-ribbon_8 PF09723.10 EMC85878.1 - 1.4 9.1 16.2 5 7.3 0.1 4.4 4 0 0 4 4 4 0 Zinc ribbon domain zf-CCHC_2 PF13696.6 EMC85878.1 - 3.6 7.5 15.9 10 6.0 2.2 3.7 3 0 0 3 3 3 0 Zinc knuckle zf_UBZ PF18439.1 EMC85878.1 - 5.4 6.7 12.4 24 4.6 0.4 4.3 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger DUF155 PF02582.14 EMC85879.1 - 1.5e-47 162.0 2.9 1.9e-47 161.7 2.9 1.1 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 UPF0449 PF15136.6 EMC85879.1 - 0.12 12.8 0.4 0.43 11.1 0.4 1.9 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 ADAM_spacer1 PF05986.14 EMC85879.1 - 0.15 12.1 0.0 0.58 10.2 0.0 1.9 2 0 0 2 2 2 0 ADAM-TS Spacer 1 DUF89 PF01937.19 EMC85880.1 - 3.1e-122 408.0 0.6 3.4e-122 407.8 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 PWI PF01480.17 EMC85880.1 - 0.39 11.1 2.1 15 6.0 0.3 2.6 2 0 0 2 2 2 0 PWI domain RVT_1 PF00078.27 EMC85881.1 - 0.0083 15.7 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Oest_recep PF02159.15 EMC85882.1 - 2.6e-67 225.6 8.1 2.6e-67 225.6 8.1 2.0 2 0 0 2 2 2 1 Oestrogen receptor Hormone_recep PF00104.30 EMC85882.1 - 1.1e-33 116.6 3.6 1.1e-33 116.6 3.6 1.5 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 EMC85882.1 - 1e-30 106.0 14.3 1.7e-30 105.2 14.3 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) ESR1_C PF12743.7 EMC85882.1 - 2.4e-19 68.8 4.1 2.4e-19 68.8 4.1 2.2 2 0 0 2 2 2 1 Oestrogen-type nuclear receptor final C-terminal Thyroglob_assoc PF16597.5 EMC85882.1 - 0.058 13.7 0.1 0.12 12.7 0.1 1.6 1 0 0 1 1 1 0 Thyroglobulin_1 repeat associated disordered domain Myc_target_1 PF15179.6 EMC85883.1 - 8.5e-56 188.9 15.0 1.8e-28 99.8 4.0 2.0 1 1 1 2 2 2 2 Myc target protein 1 Hormone_2 PF00123.20 EMC85884.1 - 1.3e-24 85.7 7.1 1e-11 44.5 0.2 3.0 3 0 0 3 3 3 2 Peptide hormone F-box PF00646.33 EMC85885.1 - 3.5e-07 29.9 0.0 7.1e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 F-box domain IBR PF01485.21 EMC85885.1 - 1e-05 25.7 11.1 2.1e-05 24.6 11.1 1.5 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain Phage_pRha PF09669.10 EMC85885.1 - 0.018 15.6 0.7 0.29 11.7 0.1 2.4 2 0 0 2 2 2 0 Phage regulatory protein Rha (Phage_pRha) F-box-like PF12937.7 EMC85885.1 - 0.037 13.9 0.0 0.074 13.0 0.0 1.5 1 0 0 1 1 1 0 F-box-like DUF1663 PF07909.11 EMC85885.1 - 0.1 11.3 0.1 0.17 10.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1663) ORF6C PF10552.9 EMC85885.1 - 0.29 11.2 2.0 4.3 7.4 0.1 2.8 2 1 1 3 3 3 0 ORF6C domain PCRF PF03462.18 EMC85886.1 - 2.6e-51 174.3 0.3 2.6e-51 174.3 0.3 2.2 2 1 0 2 2 2 1 PCRF domain RF-1 PF00472.20 EMC85886.1 - 1.2e-39 134.8 5.1 2.6e-39 133.8 5.1 1.5 1 0 0 1 1 1 1 RF-1 domain RGS PF00615.19 EMC85887.1 - 5.8e-36 123.3 1.5 7.9e-36 122.9 1.5 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain 7tm_1 PF00001.21 EMC85888.1 - 4.5e-58 196.7 24.9 5.3e-58 196.4 24.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 EMC85888.1 - 6.1e-09 35.6 14.6 7.6e-09 35.3 14.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 EMC85888.1 - 0.00029 20.6 21.6 0.00044 20.0 21.6 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC85888.1 - 0.0073 16.1 14.3 0.015 15.0 14.3 1.5 1 1 0 1 1 1 1 Olfactory receptor DUF2824 PF11039.8 EMC85888.1 - 0.0084 16.1 0.2 0.035 14.1 0.1 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF2824) CitMHS PF03600.16 EMC85888.1 - 0.38 9.9 5.9 0.52 9.5 5.9 1.3 1 0 0 1 1 1 0 Citrate transporter DUF1170 PF06663.13 EMC85889.1 - 3.7e-76 255.6 1.5 1.1e-75 254.0 1.5 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1170) CRIC_ras_sig PF10534.9 EMC85889.1 - 2.2e-38 130.3 0.1 6.6e-38 128.8 0.1 1.9 1 0 0 1 1 1 1 Connector enhancer of kinase suppressor of ras PH PF00169.29 EMC85889.1 - 6.2e-15 55.6 1.4 6.2e-15 55.6 1.4 2.3 3 0 0 3 3 1 1 PH domain SAM_1 PF00536.30 EMC85889.1 - 3.8e-12 46.5 0.4 3.8e-12 46.5 0.4 1.8 2 0 0 2 2 1 1 SAM domain (Sterile alpha motif) PDZ PF00595.24 EMC85889.1 - 1.2e-09 38.4 0.0 2.7e-09 37.3 0.0 1.7 1 0 0 1 1 1 1 PDZ domain SAM_2 PF07647.17 EMC85889.1 - 2.2e-08 34.1 0.5 7.5e-08 32.4 0.5 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDZ_6 PF17820.1 EMC85889.1 - 1.7e-06 27.7 0.4 4.8e-06 26.3 0.1 1.9 2 0 0 2 2 2 1 PDZ domain SNARE PF05739.19 EMC85889.1 - 3.6e-05 23.6 4.3 3.6e-05 23.6 4.3 1.8 2 0 0 2 2 1 1 SNARE domain PDZ_2 PF13180.6 EMC85889.1 - 0.0043 17.3 0.0 0.01 16.2 0.0 1.6 1 0 0 1 1 1 1 PDZ domain DUF3139 PF11337.8 EMC85889.1 - 0.0067 17.1 0.5 0.02 15.5 0.5 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3139) TMEM154 PF15102.6 EMC85889.1 - 0.013 15.4 3.3 0.013 15.4 0.2 2.4 2 0 0 2 2 2 0 TMEM154 protein family Flp1_like PF16982.5 EMC85889.1 - 0.029 13.8 8.2 0.058 12.8 8.2 1.4 1 0 0 1 1 1 0 Putative Flagellin, Flp1-like, domain DUF929 PF06053.11 EMC85889.1 - 0.1 11.9 0.5 0.18 11.1 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF929) Orf78 PF06024.12 EMC85889.1 - 0.11 12.8 0.1 0.32 11.3 0.1 1.7 1 0 0 1 1 1 0 Orf78 (ac78) SecD-TM1 PF13721.6 EMC85889.1 - 0.19 12.2 0.4 1.3 9.5 0.0 2.3 2 0 0 2 2 2 0 SecD export protein N-terminal TM region PH_11 PF15413.6 EMC85889.1 - 0.35 11.3 8.5 14 6.2 8.5 2.8 1 1 0 1 1 1 0 Pleckstrin homology domain PH_9 PF15410.6 EMC85889.1 - 0.37 11.2 5.3 5 7.5 1.7 3.3 3 1 0 3 3 2 0 Pleckstrin homology domain Synaptobrevin PF00957.21 EMC85889.1 - 0.52 10.1 4.8 1.5 8.7 4.8 1.7 1 0 0 1 1 1 0 Synaptobrevin Sigma_reg_N PF13800.6 EMC85889.1 - 0.93 9.8 6.1 0.28 11.5 2.4 2.0 2 0 0 2 2 1 0 Sigma factor regulator N-terminal FidL_like PF15941.5 EMC85890.1 - 0.02 15.4 0.1 0.033 14.6 0.1 1.4 1 0 0 1 1 1 0 FidL-like putative membrane protein B_lectin PF01453.24 EMC85890.1 - 0.094 13.3 0.1 0.2 12.2 0.1 1.6 1 1 0 1 1 1 0 D-mannose binding lectin RrnaAD PF00398.20 EMC85891.1 - 7.7e-41 139.9 0.0 9.7e-41 139.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Amelogenin PF02948.15 EMC85891.1 - 0.012 16.2 0.0 0.02 15.6 0.0 1.3 1 0 0 1 1 1 0 Amelogenin PMP22_Claudin PF00822.20 EMC85892.1 - 5.4e-27 94.7 8.8 6.6e-27 94.4 8.8 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC85892.1 - 3.3e-08 33.5 8.1 1.9e-06 27.8 8.1 2.4 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF3185 PF11381.8 EMC85892.1 - 0.11 12.5 1.4 1.9 8.6 0.4 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3185) DUF872 PF05915.12 EMC85892.1 - 0.13 12.4 1.1 0.19 11.9 0.1 1.7 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) NAD_binding_6 PF08030.12 EMC85893.1 - 3.5e-29 102.0 0.2 4.4e-28 98.4 0.0 2.3 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EMC85893.1 - 8.5e-26 90.5 2.3 2e-25 89.3 2.3 1.7 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EMC85893.1 - 1.2e-19 70.4 0.1 4.7e-19 68.5 0.0 1.9 1 1 1 2 2 2 1 FAD-binding domain FAD_binding_6 PF00970.24 EMC85893.1 - 0.0058 16.9 0.0 0.013 15.8 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain PDGLE PF13190.6 EMC85893.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 PDGLE domain BAF250_C PF12031.8 EMC85895.1 - 1.3e-121 404.8 0.0 2.4e-121 403.9 0.0 1.5 1 0 0 1 1 1 1 SWI/SNF-like complex subunit BAF250/Osa ARID PF01388.21 EMC85895.1 - 1.2e-17 64.3 0.0 2.9e-17 63.1 0.0 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain DUF1358 PF07096.11 EMC85896.1 - 2.7e-40 137.0 1.0 3e-40 136.8 1.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1358) NifQ PF04891.12 EMC85896.1 - 0.021 15.2 0.0 0.03 14.7 0.0 1.2 1 0 0 1 1 1 0 NifQ DHHC PF01529.20 EMC85897.1 - 1.3e-35 122.5 8.1 1.3e-35 122.5 8.1 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase Imm17 PF15562.6 EMC85897.1 - 3.4 7.6 8.1 0.78 9.7 0.1 2.7 3 0 0 3 3 3 0 Immunity protein 17 BAR_3_WASP_bdg PF10456.9 EMC85898.1 - 1.3e-113 378.3 0.6 1.7e-113 377.9 0.6 1.2 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein PX PF00787.24 EMC85898.1 - 1.5e-23 82.9 0.2 3.2e-23 81.9 0.2 1.6 1 0 0 1 1 1 1 PX domain SH3_1 PF00018.28 EMC85898.1 - 2.7e-09 36.5 0.4 8.3e-09 34.9 0.0 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EMC85898.1 - 1e-08 34.9 0.3 2.5e-08 33.6 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EMC85898.1 - 9.7e-08 31.6 0.1 2.1e-07 30.5 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain Vps5 PF09325.10 EMC85898.1 - 0.0072 15.9 0.0 1.5 8.3 0.1 2.4 1 1 1 2 2 2 2 Vps5 C terminal like Syja_N PF02383.18 EMC85900.1 - 9.8e-66 222.2 0.0 3.5e-65 220.4 0.0 1.8 2 0 0 2 2 2 1 SacI homology domain DUF1866 PF08952.11 EMC85900.1 - 1.4e-55 187.2 0.5 7e-55 184.9 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1866) Exo_endo_phos PF03372.23 EMC85900.1 - 2.7e-13 50.0 0.0 4.9e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RRM_1 PF00076.22 EMC85900.1 - 0.0056 16.5 0.2 0.017 14.9 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Tfb5 PF06331.12 EMC85901.1 - 1.3e-29 102.0 0.2 1.4e-29 101.9 0.2 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 MIG-14_Wnt-bd PF06664.12 EMC85902.1 - 1.9e-93 312.9 35.8 1.9e-93 312.9 35.8 1.9 2 0 0 2 2 2 1 Wnt-binding factor required for Wnt secretion PSII_Ycf12 PF05969.11 EMC85902.1 - 5.8 7.0 6.4 2.3 8.3 0.1 2.8 2 1 0 2 2 2 0 Photosystem II complex subunit Ycf12 Tctex-1 PF03645.13 EMC85903.1 - 1.2e-33 115.4 0.7 1.4e-33 115.2 0.7 1.0 1 0 0 1 1 1 1 Tctex-1 family C2 PF00168.30 EMC85904.1 - 2.9e-18 66.1 0.0 7.8e-16 58.3 0.0 2.5 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.16 EMC85904.1 - 1.3e-17 64.1 12.4 1.3e-17 64.1 12.4 1.7 2 0 0 2 2 2 1 FYVE-type zinc finger ERM PF00769.19 EMC85905.1 - 4.9e-69 232.9 41.4 4.9e-69 232.9 41.4 2.2 1 1 1 2 2 2 1 Ezrin/radixin/moesin family FERM_C PF09380.10 EMC85905.1 - 6e-28 97.1 0.5 1.9e-27 95.4 0.0 2.2 2 0 0 2 2 2 1 FERM C-terminal PH-like domain FERM_M PF00373.18 EMC85905.1 - 9.3e-28 97.0 0.2 9.3e-28 97.0 0.2 3.4 2 1 0 2 2 2 1 FERM central domain FERM_N PF09379.10 EMC85905.1 - 1.5e-14 53.7 1.6 4.5e-14 52.1 0.1 2.6 3 0 0 3 3 3 1 FERM N-terminal domain RhoGAP PF00620.27 EMC85906.1 - 1.5e-12 47.6 0.7 2.4e-12 46.9 0.7 1.3 1 0 0 1 1 1 1 RhoGAP domain RhoGAP PF00620.27 EMC85907.1 - 3e-38 131.0 1.1 8.6e-38 129.5 1.1 1.8 1 0 0 1 1 1 1 RhoGAP domain bMG6 PF17962.1 EMC85907.1 - 0.032 14.4 0.0 0.072 13.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial macroglobulin domain 6 Radial_spoke_3 PF06098.11 EMC85908.1 - 2e-127 424.3 9.9 2.3e-127 424.2 9.9 1.0 1 0 0 1 1 1 1 Radial spoke protein 3 DUF2866 PF11065.8 EMC85908.1 - 0.072 13.1 1.0 5.3 7.1 1.2 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2866) Integrin_alpha2 PF08441.12 EMC85908.1 - 0.72 8.7 3.8 0.97 8.2 0.1 2.0 2 0 0 2 2 2 0 Integrin alpha Spt5_N PF11942.8 EMC85908.1 - 1.7 9.7 10.1 5.6 8.0 5.4 2.4 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal SET PF00856.28 EMC85909.1 - 0.0037 17.7 0.0 0.043 14.2 0.0 2.1 1 1 0 1 1 1 1 SET domain zf-C2H2 PF00096.26 EMC85909.1 - 5.9 7.6 8.7 5.1 7.8 0.7 3.2 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-C2HC_2 PF13913.6 EMC85910.1 - 2.3e-16 59.2 7.6 2.6e-09 36.7 0.3 2.3 2 0 0 2 2 2 2 zinc-finger of a C2HC-type zf-CpG_bind_C PF12269.8 EMC85910.1 - 0.0055 16.5 0.9 1.6 8.5 0.2 2.2 1 1 1 2 2 2 2 CpG binding protein zinc finger C terminal domain zf-C2H2_4 PF13894.6 EMC85910.1 - 0.0055 17.4 14.0 0.068 14.0 1.5 4.0 4 1 0 4 4 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC85910.1 - 0.014 15.8 11.9 0.76 10.4 0.2 3.9 4 0 0 4 4 4 0 Zinc finger, C2H2 type DNA_RNApol_7kD PF03604.13 EMC85910.1 - 0.02 14.6 1.2 4 7.2 0.1 2.7 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit SbsC_C PF18058.1 EMC85910.1 - 0.025 14.8 0.3 0.034 14.4 0.3 1.2 1 0 0 1 1 1 0 SbsC C-terminal domain zf-RING_7 PF02591.15 EMC85910.1 - 0.025 14.7 4.7 3.9 7.7 0.9 3.5 3 1 0 3 3 3 0 C4-type zinc ribbon domain zf-C2H2_11 PF16622.5 EMC85910.1 - 0.048 13.4 1.7 1.2 8.9 0.2 2.4 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-Di19 PF05605.12 EMC85910.1 - 0.051 13.9 3.7 0.35 11.2 0.5 2.7 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding ROS_MUCR PF05443.11 EMC85910.1 - 0.051 13.6 0.1 0.25 11.4 0.0 2.0 2 0 0 2 2 2 0 ROS/MUCR transcriptional regulator protein zf-CHCC PF10276.9 EMC85910.1 - 0.11 12.6 1.7 1.8 8.7 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger domain zinc_ribbon_9 PF14369.6 EMC85910.1 - 0.2 11.9 2.7 3.3 8.0 0.6 2.4 2 0 0 2 2 2 0 zinc-ribbon zf-H2C2_2 PF13465.6 EMC85910.1 - 0.39 11.2 6.8 2.9 8.5 0.1 3.7 4 0 0 4 4 4 0 Zinc-finger double domain zinc_ribbon_4 PF13717.6 EMC85910.1 - 0.41 10.6 5.3 1.3 9.0 0.4 2.9 3 0 0 3 3 3 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 EMC85910.1 - 0.59 10.3 4.2 18 5.5 0.4 2.8 2 1 1 3 3 3 0 Zinc ribbon domain FYVE PF01363.21 EMC85910.1 - 0.66 10.1 6.0 4.1 7.6 0.7 2.4 2 1 0 2 2 2 0 FYVE zinc finger zf_UBZ PF18439.1 EMC85910.1 - 1.5 8.5 9.9 2.6 7.7 0.3 3.2 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger YacG PF03884.14 EMC85910.1 - 1.6 8.5 7.8 0.74 9.6 0.8 2.8 2 1 1 3 3 3 0 DNA gyrase inhibitor YacG LTV PF04180.14 EMC85911.1 - 4.8e-87 293.2 18.3 6.5e-86 289.5 18.3 2.3 1 1 0 1 1 1 1 Low temperature viability protein UPF0767 PF15990.5 EMC85911.1 - 1.5 9.0 7.4 1.1 9.5 5.0 2.0 2 0 0 2 2 2 0 UPF0767 family RPEL PF02755.15 EMC85912.1 - 7.6e-28 95.4 21.9 1.3e-07 31.1 2.5 4.5 4 0 0 4 4 4 4 RPEL repeat SieB PF14163.6 EMC85912.1 - 0.28 10.7 2.7 1.6 8.2 2.7 2.1 1 1 1 2 2 2 0 Super-infection exclusion protein B Alpha_L_fucos PF01120.17 EMC85913.1 - 6.3e-99 331.7 0.1 7.4e-99 331.5 0.1 1.0 1 0 0 1 1 1 1 Alpha-L-fucosidase Fucosidase_C PF16757.5 EMC85913.1 - 7.8e-27 93.7 0.2 1.5e-26 92.8 0.2 1.5 1 0 0 1 1 1 1 Alpha-L-fucosidase C-terminal domain Peroxin-3 PF04882.12 EMC85914.1 - 2.9e-66 224.4 5.1 9.5e-49 166.6 0.6 3.0 1 1 1 2 2 2 2 Peroxin-3 DUF4174 PF13778.6 EMC85914.1 - 0.092 13.2 0.1 1.1 9.7 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4174) DUF3631 PF12307.8 EMC85914.1 - 0.15 12.2 0.2 0.6 10.3 0.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3631) dCMP_cyt_deam_1 PF00383.23 EMC85915.1 - 8.9e-21 73.7 1.3 1.3e-20 73.1 1.3 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EMC85915.1 - 8.1e-19 67.7 0.1 1.2e-18 67.2 0.1 1.2 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 EMC85915.1 - 0.00015 21.8 3.6 0.0021 18.1 3.6 2.1 1 1 0 1 1 1 1 Bd3614-like deaminase APOBEC2 PF18772.1 EMC85915.1 - 0.00036 20.7 0.0 0.0005 20.2 0.0 1.2 1 0 0 1 1 1 1 APOBEC2 SNAD4 PF18750.1 EMC85915.1 - 0.00044 20.3 0.0 0.00069 19.7 0.0 1.2 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 NAD1 PF18778.1 EMC85915.1 - 0.002 18.2 0.0 0.0028 17.7 0.0 1.2 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 APOBEC3 PF18771.1 EMC85915.1 - 0.0021 18.2 0.0 0.0033 17.6 0.0 1.3 1 0 0 1 1 1 1 APOBEC3 Inv-AAD PF18785.1 EMC85915.1 - 0.008 16.0 0.1 0.012 15.5 0.1 1.3 1 0 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase NAD2 PF18782.1 EMC85915.1 - 0.017 15.2 0.0 0.025 14.7 0.0 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 2 APOBEC_N PF08210.11 EMC85915.1 - 0.019 14.9 0.2 0.028 14.3 0.2 1.2 1 0 0 1 1 1 0 APOBEC-like N-terminal domain APOBEC4_like PF18774.1 EMC85915.1 - 0.03 14.3 0.0 0.045 13.7 0.0 1.3 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase Far-17a_AIG1 PF04750.14 EMC85916.1 - 4.1e-78 261.3 13.0 4.7e-78 261.1 13.0 1.0 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein zf-C2H2 PF00096.26 EMC85917.1 - 2.7e-18 65.3 27.8 0.00012 22.4 1.4 5.1 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EMC85917.1 - 1.2e-10 41.4 23.7 0.0022 18.2 1.5 5.0 4 0 0 4 4 4 4 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 EMC85917.1 - 1.2e-10 41.3 37.2 1.8e-06 28.1 1.0 5.3 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC85917.1 - 1.8e-09 37.6 23.8 0.072 14.0 0.4 5.2 4 0 0 4 4 4 4 C2H2-type zinc finger zf-met PF12874.7 EMC85917.1 - 8e-05 22.9 25.4 0.0096 16.3 2.8 5.2 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 EMC85917.1 - 0.00076 19.2 21.7 0.16 11.8 0.8 4.7 4 0 0 4 4 4 3 C2H2-type zinc-finger domain zf-C2H2_3rep PF18868.1 EMC85917.1 - 0.071 13.8 7.6 8.4 7.1 0.4 4.3 2 1 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats NOA36 PF06524.12 EMC85917.1 - 0.22 10.8 23.3 0.21 10.9 14.0 2.4 2 0 0 2 2 2 0 NOA36 protein zf-C2H2_2 PF12756.7 EMC85917.1 - 0.37 11.1 17.8 0.61 10.5 5.7 4.1 2 2 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 EMC85917.1 - 7.1 7.0 14.8 4.3 7.7 4.0 3.0 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding 7tm_2 PF00002.24 EMC85918.1 - 2.8e-48 164.4 16.7 2.8e-48 164.4 16.7 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) CUB PF00431.20 EMC85918.1 - 1.7e-24 86.2 0.0 4.4e-24 84.9 0.0 1.7 1 0 0 1 1 1 1 CUB domain GPS PF01825.21 EMC85918.1 - 6e-17 61.9 2.2 1.9e-16 60.3 2.2 2.0 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Pentaxin PF00354.17 EMC85918.1 - 1.9e-09 37.5 1.2 6.5e-09 35.8 0.1 2.2 2 0 0 2 2 2 1 Pentaxin family Laminin_G_3 PF13385.6 EMC85918.1 - 0.016 15.3 0.1 0.04 14.1 0.1 1.7 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily CUB_2 PF02408.20 EMC85918.1 - 0.033 14.0 0.1 0.14 11.9 0.1 2.1 1 0 0 1 1 1 0 CUB-like domain FIVAR PF07554.13 EMC85918.1 - 0.057 14.2 2.5 0.093 13.5 0.4 2.5 2 0 0 2 2 2 0 FIVAR domain TipAS PF07739.13 EMC85918.1 - 0.18 12.3 0.0 0.61 10.6 0.0 1.8 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain Vta1 PF04652.16 EMC85919.1 - 2.3e-40 137.9 2.0 6.3e-40 136.5 1.0 1.9 2 0 0 2 2 2 1 Vta1 like Vta1_C PF18097.1 EMC85919.1 - 7.5e-19 67.2 0.5 1.5e-18 66.2 0.5 1.5 1 0 0 1 1 1 1 Vta1 C-terminal domain DAG_kinase_N PF14513.6 EMC85919.1 - 0.13 12.5 0.5 0.36 11.0 0.0 1.9 2 1 0 2 2 2 0 Diacylglycerol kinase N-terminus Connexin PF00029.19 EMC85920.1 - 6.1e-27 94.9 15.1 2.7e-13 50.2 0.3 2.0 1 1 1 2 2 2 2 Connexin DUF846 PF05832.12 EMC85920.1 - 0.0065 16.5 13.3 0.37 10.8 10.9 2.8 1 1 1 2 2 2 2 Eukaryotic protein of unknown function (DUF846) 7tm_1 PF00001.21 EMC85921.1 - 6.8e-53 179.7 14.0 9e-53 179.3 14.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 EMC85921.1 - 2.8e-10 40.0 9.1 2.8e-10 40.0 9.1 1.4 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 EMC85921.1 - 4.2e-07 29.6 13.0 6e-07 29.1 13.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 EMC85921.1 - 0.79 8.9 15.9 1.5 8.0 14.3 2.1 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srw Headcase PF16002.5 EMC85922.1 - 4.2e-83 277.7 3.9 4.2e-83 277.7 3.9 1.7 2 0 0 2 2 2 1 Headcase protein HECA PF15353.6 EMC85922.1 - 4.2e-40 136.1 8.9 1.2e-39 134.7 8.9 1.8 1 0 0 1 1 1 1 Headcase protein family homologue VATC PF18716.1 EMC85922.1 - 1.3 8.9 15.7 0.83 9.6 1.2 5.2 4 1 0 4 4 4 0 Vms1-associating treble clef domain HypA PF01155.19 EMC85922.1 - 5.3 7.1 7.6 9.6 6.3 4.3 2.6 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_2 PF13240.6 EMC85922.1 - 7.2 6.5 10.9 5.8 6.8 0.4 3.4 3 0 0 3 3 3 0 zinc-ribbon domain DnaJ_C PF01556.18 EMC85923.1 - 4e-44 150.3 0.1 5e-44 150.0 0.1 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain F5_F8_type_C PF00754.25 EMC85924.1 - 5.4e-18 65.3 2.5 6.2e-18 65.1 2.5 1.0 1 0 0 1 1 1 1 F5/8 type C domain RVT_1 PF00078.27 EMC85925.1 - 0.048 13.2 0.0 0.12 11.9 0.0 1.7 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 EMC85927.1 - 0.0031 17.0 0.0 0.005 16.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TPK_catalytic PF04263.16 EMC85928.1 - 3.4e-40 136.8 0.0 4.2e-40 136.5 0.0 1.1 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 EMC85928.1 - 2.4e-23 81.6 0.3 3.6e-23 81.0 0.3 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain SecE PF00584.20 EMC85929.1 - 6.4e-17 61.2 0.1 8.1e-17 60.9 0.1 1.2 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex TPR_11 PF13414.6 EMC85930.1 - 0.24 11.1 2.0 15 5.4 0.1 2.9 3 0 0 3 3 3 0 TPR repeat TPR_2 PF07719.17 EMC85930.1 - 1.8 8.8 13.0 1.7 8.9 0.1 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 EMC85930.1 - 3.9 7.5 6.6 60 3.7 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF5401 PF17380.2 EMC85930.1 - 8.6 4.3 59.7 12 3.8 59.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5401) Pkinase_Tyr PF07714.17 EMC85931.1 - 5.8e-89 297.8 0.0 8.5e-89 297.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.24 EMC85931.1 - 3.7e-60 200.9 2.3 5e-30 103.9 2.2 2.5 2 0 0 2 2 2 2 Receptor L domain GF_recep_IV PF14843.6 EMC85931.1 - 2.4e-55 185.9 81.3 6.8e-48 161.8 25.3 4.0 2 1 1 3 3 3 3 Growth factor receptor domain IV Pkinase PF00069.25 EMC85931.1 - 7.5e-40 137.0 0.0 1.1e-39 136.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.20 EMC85931.1 - 2.1e-35 121.8 88.9 3.9e-30 104.7 42.6 4.2 2 1 2 4 4 4 3 Furin-like cysteine rich region APH PF01636.23 EMC85931.1 - 0.022 14.7 0.0 0.036 14.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EMC85931.1 - 0.064 12.2 0.0 0.13 11.2 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 EMC85931.1 - 0.11 11.8 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 Kinase-like TMEM52 PF14979.6 EMC85932.1 - 0.054 13.4 9.3 0.15 12.0 1.8 2.2 2 0 0 2 2 2 0 Transmembrane 52 WBP-1 PF11669.8 EMC85932.1 - 0.089 13.4 19.9 0.52 11.0 19.9 2.2 1 1 0 1 1 1 0 WW domain-binding protein 1 Biliv-reduc_cat PF09166.10 EMC85933.1 - 1.5e-56 189.6 0.0 2.5e-56 188.9 0.0 1.4 1 0 0 1 1 1 1 Biliverdin reductase, catalytic GFO_IDH_MocA PF01408.22 EMC85933.1 - 2.1e-17 64.1 0.5 5.8e-17 62.6 0.5 1.8 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 EMC85933.1 - 0.14 12.8 0.0 0.26 12.0 0.0 1.5 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain Coa1 PF08695.10 EMC85934.1 - 1.1e-20 73.5 0.0 1.3e-20 73.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 TIM21 PF08294.11 EMC85934.1 - 0.01 15.7 0.0 0.015 15.2 0.0 1.3 1 1 0 1 1 1 0 TIM21 TPR_11 PF13414.6 EMC85934.1 - 0.15 11.8 0.7 0.24 11.1 0.7 1.3 1 0 0 1 1 1 0 TPR repeat Pkinase PF00069.25 EMC85935.1 - 6.3e-70 235.5 0.0 1e-69 234.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC85935.1 - 1e-31 110.2 0.1 1.5e-31 109.6 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC85935.1 - 4e-05 23.1 0.0 6.6e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC85935.1 - 0.00012 21.6 0.1 0.00019 20.9 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SPOUT_MTase_2 PF14419.6 EMC85935.1 - 0.042 13.2 0.1 0.068 12.5 0.1 1.3 1 0 0 1 1 1 0 AF2226-like SPOUT RNA Methylase fused to THUMP RIO1 PF01163.22 EMC85935.1 - 0.044 13.4 0.2 0.086 12.4 0.2 1.5 1 1 0 1 1 1 0 RIO1 family APH PF01636.23 EMC85935.1 - 0.058 13.3 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family SRA1 PF07304.11 EMC85935.1 - 0.06 13.1 0.2 0.12 12.2 0.2 1.5 1 0 0 1 1 1 0 Steroid receptor RNA activator (SRA1) Pox_ser-thr_kin PF05445.11 EMC85935.1 - 0.16 10.9 0.2 0.29 10.0 0.1 1.5 1 1 0 1 1 1 0 Poxvirus serine/threonine protein kinase HECT PF00632.25 EMC85936.1 - 5.7e-106 354.4 0.0 8.2e-106 353.9 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) HECW_N PF16562.5 EMC85936.1 - 3.8e-59 197.7 0.6 8.2e-59 196.7 0.6 1.6 1 0 0 1 1 1 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 HECW1_helix PF18436.1 EMC85936.1 - 8.2e-38 128.4 4.4 8.6e-35 118.7 2.7 2.7 2 0 0 2 2 2 2 Helical box domain of E3 ubiquitin-protein ligase HECW1 WW PF00397.26 EMC85936.1 - 2.2e-17 62.8 0.5 9.2e-10 38.4 0.5 2.7 2 0 0 2 2 2 2 WW domain C2 PF00168.30 EMC85936.1 - 8.2e-11 42.1 0.0 3.2e-10 40.2 0.0 2.0 2 0 0 2 2 2 1 C2 domain RFXA_RFXANK_bdg PF15289.6 EMC85936.1 - 4.7 7.5 7.5 1.4 9.3 0.1 3.2 3 0 0 3 3 3 0 Regulatory factor X-associated C-terminal binding domain PDEase_I PF00233.19 EMC85939.1 - 1.6e-83 280.1 4.7 1.6e-83 280.1 4.7 1.8 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase PDEase_I_N PF08499.12 EMC85939.1 - 9.7e-32 108.6 0.1 2.6e-31 107.2 0.1 1.8 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase N-terminal Red1 PF07964.11 EMC85939.1 - 5.1 5.2 19.2 7.2 4.7 19.2 1.1 1 0 0 1 1 1 0 Rec10 / Red1 Aa_trans PF01490.18 EMC85940.1 - 3.8e-71 240.0 25.6 4.3e-71 239.8 25.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Bac_export_2 PF01312.19 EMC85940.1 - 3.6 6.7 10.2 1.2 8.3 1.3 2.2 2 0 0 2 2 2 0 FlhB HrpN YscU SpaS Family CABIT PF12736.7 EMC85941.1 - 6.1e-111 370.2 3.3 5.7e-57 193.2 0.1 2.2 2 0 0 2 2 2 2 Cell-cycle sustaining, positive selection, DUF1966 PF09260.11 EMC85941.1 - 0.03 14.6 0.3 0.068 13.5 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1966) Leg1 PF05612.12 EMC85942.1 - 2e-81 273.7 0.0 2.3e-81 273.5 0.0 1.0 1 0 0 1 1 1 1 Leg1 SOGA PF11365.8 EMC85943.1 - 3.2e-64 214.1 54.8 1.8e-31 109.1 1.1 5.4 5 1 1 6 6 6 3 Protein SOGA TSC22 PF01166.18 EMC85943.1 - 0.00034 20.9 43.4 0.0097 16.2 0.3 7.4 7 1 0 7 7 7 3 TSC-22/dip/bun family ERM PF00769.19 EMC85943.1 - 0.0033 17.3 6.9 0.0033 17.3 6.9 4.8 3 1 2 5 5 5 1 Ezrin/radixin/moesin family DUF2968 PF11180.8 EMC85943.1 - 0.0035 17.0 7.3 0.0035 17.0 7.3 4.6 2 1 1 4 4 4 1 Protein of unknown function (DUF2968) Halo_GVPC PF05465.13 EMC85943.1 - 0.0077 16.5 0.2 0.021 15.0 0.2 1.8 1 0 0 1 1 1 1 Halobacterial gas vesicle protein C (GVPC) repeat YabA PF06156.13 EMC85943.1 - 0.067 13.8 54.9 1.1 9.9 3.5 7.1 4 3 3 7 7 7 0 Initiation control protein YabA DivIC PF04977.15 EMC85943.1 - 0.15 11.9 58.1 0.061 13.1 3.7 9.0 7 3 2 9 9 9 0 Septum formation initiator SlyX PF04102.12 EMC85943.1 - 2.1 9.0 46.6 1.5 9.5 0.2 7.8 5 3 3 8 8 8 0 SlyX Fez1 PF06818.15 EMC85943.1 - 9.2 6.7 62.4 0.091 13.2 11.9 4.4 2 2 2 4 4 4 0 Fez1 DUF4482 PF14818.6 EMC85944.1 - 1.9e-28 100.0 39.1 1.3e-22 81.1 13.9 4.7 5 0 0 5 5 5 3 Domain of unknown function (DUF4482) Myf5 PF12232.8 EMC85944.1 - 0.21 12.4 9.7 0.075 13.8 2.0 3.9 3 0 0 3 3 3 0 Myogenic determination factor 5 ECH_1 PF00378.20 EMC85945.1 - 7.3e-35 120.5 0.0 9.4e-35 120.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EMC85945.1 - 1.6e-20 73.9 0.2 2e-20 73.6 0.2 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase DUF4478 PF14793.6 EMC85945.1 - 0.074 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Pyrimidine/purine nucleotide 5'-monophosphate nucleosidases WWE PF02825.20 EMC85946.1 - 6.3e-16 58.7 3.1 6.3e-16 58.7 3.1 2.1 3 0 0 3 3 3 1 WWE domain zf-C3HC4_3 PF13920.6 EMC85946.1 - 3.9e-07 29.8 10.6 7.3e-07 29.0 10.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC85946.1 - 1.8e-05 24.5 9.4 4.3e-05 23.3 9.5 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC85946.1 - 0.00014 21.8 9.3 0.00032 20.6 9.0 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EMC85946.1 - 0.00016 22.0 12.5 0.00028 21.2 12.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC85946.1 - 0.00047 20.0 12.0 0.00083 19.1 12.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC85946.1 - 0.0032 17.3 9.9 0.0061 16.4 9.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EMC85946.1 - 0.016 15.4 10.6 0.016 15.4 10.6 1.9 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EMC85946.1 - 0.016 15.2 11.4 0.029 14.3 11.4 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_10 PF16685.5 EMC85946.1 - 0.028 14.6 7.4 0.051 13.7 7.4 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 Furin-like_2 PF15913.5 EMC85947.1 - 2.3e-45 153.2 24.0 2.3e-45 153.2 24.0 1.9 2 0 0 2 2 2 1 Furin-like repeat, cysteine-rich RR_TM4-6 PF06459.12 EMC85947.1 - 6.3 6.5 13.5 9.1 6.0 13.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 UPF0020 PF01170.18 EMC85948.1 - 5.5e-11 42.5 0.0 1.8e-10 40.8 0.0 1.7 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.16 EMC85948.1 - 1.3e-05 24.6 0.0 2.9e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 N-6 DNA Methylase N6_N4_Mtase PF01555.18 EMC85948.1 - 0.0055 16.4 0.5 0.51 10.0 0.0 2.4 2 1 0 2 2 2 2 DNA methylase DUF1296 PF06972.11 EMC85948.1 - 0.035 14.2 0.1 18 5.5 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1296) Eco57I PF07669.11 EMC85948.1 - 0.085 13.4 0.0 0.32 11.5 0.0 2.0 1 0 0 1 1 1 0 Eco57I restriction-modification methylase Costars PF14705.6 EMC85949.1 - 1.3e-33 114.9 0.1 1.6e-33 114.7 0.1 1.1 1 0 0 1 1 1 1 Costars DcpS_C PF11969.8 EMC85950.1 - 1.1e-05 25.9 0.3 1.3e-05 25.6 0.3 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding LysM PF01476.20 EMC85951.1 - 4.1e-07 29.9 0.1 8.8e-07 28.9 0.1 1.6 1 0 0 1 1 1 1 LysM domain GRAM PF02893.20 EMC85951.1 - 0.0066 16.3 0.1 0.037 13.9 0.0 2.3 2 0 0 2 2 2 1 GRAM domain HLH PF00010.26 EMC85952.1 - 5.2e-18 64.7 3.4 8.5e-18 64.1 3.4 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 EMC85952.1 - 6.3e-14 51.9 0.1 1.1e-13 51.1 0.1 1.4 1 0 0 1 1 1 1 Hairy Orange dCache_2 PF08269.11 EMC85952.1 - 0.017 14.3 0.1 0.021 14.0 0.1 1.1 1 0 0 1 1 1 0 Cache domain HTH_Crp_2 PF13545.6 EMC85952.1 - 0.11 12.5 1.3 0.32 11.0 1.3 1.8 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain DUF3772 PF12607.8 EMC85952.1 - 0.16 11.7 2.2 2.6 7.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3772) HD_3 PF13023.6 EMC85953.1 - 6e-46 156.4 0.5 7.3e-46 156.1 0.5 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 EMC85953.1 - 3.1e-14 53.1 2.5 4.3e-14 52.7 2.3 1.3 1 1 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 EMC85953.1 - 0.0005 20.3 0.1 0.00098 19.3 0.1 1.5 1 0 0 1 1 1 1 HD domain HDOD PF08668.12 EMC85953.1 - 0.067 12.7 0.1 0.1 12.1 0.1 1.2 1 0 0 1 1 1 0 HDOD domain TPD52 PF04201.15 EMC85954.1 - 6.2e-74 247.0 9.5 8e-74 246.6 9.5 1.1 1 0 0 1 1 1 1 Tumour protein D52 family NUDE_C PF04880.13 EMC85954.1 - 1e-05 26.1 4.6 1.7e-05 25.4 4.6 1.4 1 1 0 1 1 1 1 NUDE protein, C-terminal conserved region WEMBL PF05701.11 EMC85954.1 - 0.0013 17.5 2.7 0.0017 17.2 2.7 1.2 1 0 0 1 1 1 1 Weak chloroplast movement under blue light OmpH PF03938.14 EMC85954.1 - 0.0072 16.7 1.6 0.1 12.9 2.0 2.0 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) SlyX PF04102.12 EMC85954.1 - 0.022 15.3 1.3 0.046 14.3 1.3 1.7 1 0 0 1 1 1 0 SlyX Cnn_1N PF07989.11 EMC85954.1 - 0.039 14.1 2.8 0.12 12.5 2.8 1.9 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 Uds1 PF15456.6 EMC85954.1 - 0.039 14.1 6.6 0.035 14.3 5.0 1.7 2 0 0 2 2 2 0 Up-regulated During Septation Vfa1 PF08432.10 EMC85954.1 - 0.057 13.7 1.6 0.074 13.4 1.6 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 OST-HTH PF12872.7 EMC85954.1 - 0.084 12.7 0.0 0.23 11.3 0.0 1.7 1 0 0 1 1 1 0 OST-HTH/LOTUS domain DUF4140 PF13600.6 EMC85954.1 - 0.12 12.9 2.1 0.23 11.9 1.2 1.9 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) PEP-utilisers_N PF05524.13 EMC85954.1 - 0.15 12.2 2.4 0.3 11.3 2.4 1.5 1 0 0 1 1 1 0 PEP-utilising enzyme, N-terminal Atg14 PF10186.9 EMC85954.1 - 0.3 10.1 6.0 0.35 9.9 6.0 1.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 WD40_alt PF14077.6 EMC85954.1 - 2.3 8.2 6.9 0.24 11.3 2.3 1.8 2 0 0 2 2 1 0 Alternative WD40 repeat motif Prefoldin_2 PF01920.20 EMC85954.1 - 3.6 7.6 11.1 1.9 8.5 7.6 2.3 2 1 0 2 2 2 0 Prefoldin subunit FAM76 PF16046.5 EMC85954.1 - 4.9 6.4 7.5 4.7 6.5 6.7 1.4 1 1 0 1 1 1 0 FAM76 protein APG6_N PF17675.1 EMC85954.1 - 5.4 7.5 12.6 3.2 8.3 10.3 1.8 2 1 0 2 2 2 0 Apg6 coiled-coil region Fib_alpha PF08702.10 EMC85954.1 - 7.1 6.8 7.1 8.7 6.5 2.0 2.7 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family IBR PF01485.21 EMC85955.1 - 6.4e-18 64.7 27.9 4.1e-09 36.5 8.3 2.8 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain zf-UDP PF14569.6 EMC85955.1 - 6.8 6.9 22.6 6.5 7.0 0.4 3.7 1 1 2 3 3 3 0 Zinc-binding RING-finger NKAIN PF05640.14 EMC85956.1 - 2.9e-50 170.4 0.1 3.1e-50 170.3 0.1 1.0 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein Asp-B-Hydro_N PF05279.11 EMC85957.1 - 0.0021 18.2 42.0 0.054 13.6 42.0 2.3 1 1 0 1 1 1 1 Aspartyl beta-hydroxylase N-terminal region DUF2839 PF10999.8 EMC85957.1 - 0.32 11.4 0.2 0.32 11.4 0.2 2.4 3 1 0 3 3 3 0 Protein of unknown function (DUF2839) GAGA_bind PF06217.12 EMC85957.1 - 0.38 11.0 12.5 0.51 10.6 12.5 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Presenilin PF01080.17 EMC85957.1 - 0.68 8.6 14.1 0.05 12.4 8.5 1.7 2 0 0 2 2 2 0 Presenilin CDC45 PF02724.14 EMC85957.1 - 2.2 6.5 12.3 2.7 6.2 12.3 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF5427 PF10310.9 EMC85957.1 - 2.4 7.0 18.2 3.4 6.5 18.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Neur_chan_memb PF02932.16 EMC85957.1 - 6.6 6.7 9.5 13 5.8 9.5 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Endostatin PF06482.11 EMC85957.1 - 8.6 5.7 8.0 12 5.3 8.0 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin CRAL_TRIO PF00650.20 EMC85958.1 - 1.2e-34 119.3 0.0 2.3e-34 118.4 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EMC85958.1 - 1.7e-08 34.7 0.0 2.7e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EMC85958.1 - 2e-06 27.9 0.0 4.4e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Metallophos PF00149.28 EMC85959.1 - 3.2e-14 53.9 0.2 4.5e-14 53.4 0.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EMC85959.1 - 0.23 11.6 0.0 1.6 8.9 0.0 2.3 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Lipocalin PF00061.23 EMC85960.1 - 5.4e-20 72.1 1.2 5.9e-20 71.9 1.2 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Myosin_N PF02736.19 EMC85960.1 - 0.58 10.0 6.4 2.1 8.3 0.3 3.0 2 1 1 3 3 3 0 Myosin N-terminal SH3-like domain Serinc PF03348.15 EMC85961.1 - 1.2e-176 587.9 13.4 1.3e-176 587.7 13.4 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) Vert_HS_TF PF06546.11 EMC85962.1 - 3.3e-73 246.7 21.6 5.4e-73 246.0 20.6 1.9 2 0 0 2 2 2 1 Vertebrate heat shock transcription factor HSF_DNA-bind PF00447.17 EMC85962.1 - 1.3e-24 86.6 0.4 3e-24 85.5 0.4 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding HALZ PF02183.18 EMC85962.1 - 0.0077 16.4 0.3 0.02 15.1 0.3 1.7 1 0 0 1 1 1 1 Homeobox associated leucine zipper APG6_N PF17675.1 EMC85962.1 - 0.012 16.1 1.2 0.027 15.0 1.2 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region bZIP_2 PF07716.15 EMC85962.1 - 0.035 14.2 2.0 0.098 12.8 2.0 1.8 1 0 0 1 1 1 0 Basic region leucine zipper LMBR1 PF04791.16 EMC85962.1 - 1.4 7.7 3.1 2.1 7.2 3.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DR2241 PF18069.1 EMC85963.1 - 0.0064 16.3 0.0 0.0073 16.2 0.0 1.1 1 0 0 1 1 1 1 DR2241 stabilising domain Ribosomal_L29 PF00831.23 EMC85963.1 - 0.058 13.4 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 Ribosomal L29 protein DUF4456 PF14644.6 EMC85963.1 - 0.1 12.3 2.0 0.11 12.1 2.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4456) Connexin PF00029.19 EMC85964.1 - 8.8e-95 316.9 2.1 1.4e-94 316.3 2.1 1.3 1 0 0 1 1 1 1 Connexin Connexin43 PF03508.13 EMC85964.1 - 4.6e-11 42.1 15.4 1e-10 41.0 15.4 1.6 1 0 0 1 1 1 1 Gap junction alpha-1 protein (Cx43) Connexin40_C PF16791.5 EMC85964.1 - 2.6e-06 28.6 2.0 4.2e-06 28.0 2.0 1.3 1 0 0 1 1 1 1 Connexin 40 C-terminal domain TEX29 PF15839.5 EMC85964.1 - 4.3 8.0 5.8 1.5 9.5 0.2 2.5 2 1 0 2 2 2 0 Testis-expressed sequence 29 protein BROMI PF14961.6 EMC85965.1 - 0 2304.4 24.8 0 2304.2 24.8 1.0 1 0 0 1 1 1 1 Broad-minded protein RabGAP-TBC PF00566.18 EMC85965.1 - 0.0018 17.9 2.0 0.0058 16.3 2.0 2.0 1 0 0 1 1 1 1 Rab-GTPase-TBC domain UBN_AB PF14075.6 EMC85965.1 - 0.022 14.5 9.9 0.42 10.3 0.1 3.5 3 1 1 4 4 4 0 Ubinuclein conserved middle domain Nod1 PF17114.5 EMC85965.1 - 0.033 14.4 0.6 0.1 12.7 0.1 2.1 2 0 0 2 2 2 0 Gef2-related medial cortical node protein Nod1 Ins_allergen_rp PF06757.13 EMC85965.1 - 0.11 12.5 2.1 1.7 8.6 0.2 3.3 3 0 0 3 3 3 0 Insect allergen related repeat, nitrile-specifier detoxification TetR_C_19 PF17924.1 EMC85965.1 - 2.9 8.5 5.5 5.8 7.5 3.9 2.5 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Glyco_hydro_47 PF01532.20 EMC85966.1 - 5.2e-155 516.8 0.0 5.9e-155 516.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 TBPIP PF07106.13 EMC85966.1 - 0.11 12.4 0.0 0.32 11.0 0.0 1.7 1 0 0 1 1 1 0 TBPIP/Hop2 winged helix domain ASF1_hist_chap PF04729.13 EMC85968.1 - 3.4e-67 225.2 0.0 4.2e-67 224.9 0.0 1.1 1 0 0 1 1 1 1 ASF1 like histone chaperone UPF0154 PF03672.13 EMC85968.1 - 0.069 13.2 0.0 0.15 12.1 0.0 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0154) Phospholamban PF04272.14 EMC85970.1 - 3.5e-32 109.7 9.1 3.7e-32 109.5 9.1 1.0 1 0 0 1 1 1 1 Phospholamban Sarcolipin PF05366.11 EMC85970.1 - 0.0057 16.3 4.5 0.01 15.5 4.5 1.5 1 0 0 1 1 1 1 Sarcolipin Anoctamin PF04547.12 EMC85970.1 - 0.13 11.0 0.5 0.13 11.1 0.5 1.0 1 0 0 1 1 1 0 Calcium-activated chloride channel SLC35F PF06027.12 EMC85971.1 - 1.5e-120 402.3 19.2 1.8e-120 402.0 19.2 1.0 1 0 0 1 1 1 1 Solute carrier family 35 EamA PF00892.20 EMC85971.1 - 1.6e-14 54.2 23.9 3.1e-09 37.1 11.2 2.1 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 EMC85971.1 - 2.1e-09 36.8 7.3 2.1e-09 36.8 7.3 1.9 1 1 1 2 2 2 1 CRT-like, chloroquine-resistance transporter-like Mg_trans_NIPA PF05653.14 EMC85971.1 - 0.00093 18.4 2.5 0.00093 18.4 2.5 1.9 1 1 1 3 3 3 1 Magnesium transporter NIPA DUF809 PF05663.11 EMC85971.1 - 0.12 12.5 0.1 0.12 12.5 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF809) Prenyltransf PF01255.19 EMC85972.1 - 1.4e-08 34.5 0.0 1.6e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Methyltransf_11 PF08241.12 EMC85972.1 - 0.0039 17.8 0.1 0.0058 17.3 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC85972.1 - 0.0051 17.5 0.1 0.0079 16.9 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC85972.1 - 0.0057 17.3 0.1 0.0088 16.7 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain DUF5099 PF17025.5 EMC85972.1 - 0.041 14.3 0.2 0.13 12.7 0.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF5099) Methyltransf_31 PF13847.6 EMC85972.1 - 0.065 13.0 0.6 0.24 11.2 0.6 1.8 1 1 0 1 1 1 0 Methyltransferase domain LRR_8 PF13855.6 EMC85973.1 - 1.2e-57 191.5 52.7 1.2e-13 50.6 0.8 7.0 6 1 0 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 EMC85973.1 - 2.4e-35 120.0 55.1 2.8e-06 27.6 0.8 10.2 3 3 9 12 12 12 12 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC85973.1 - 1.9e-12 47.0 28.2 0.00019 21.0 1.2 5.9 1 1 4 6 6 6 4 Leucine-rich repeat LRR_5 PF13306.6 EMC85973.1 - 8.3e-12 45.2 5.5 6.1e-07 29.4 0.5 4.6 3 2 1 4 4 4 2 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EMC85973.1 - 2e-11 42.8 38.3 0.092 13.3 0.1 14.2 14 1 0 14 14 14 3 Leucine Rich Repeat LRR_6 PF13516.6 EMC85973.1 - 0.0082 16.1 36.7 0.65 10.2 0.1 11.1 13 0 0 13 13 13 2 Leucine Rich repeat FNIP PF05725.12 EMC85973.1 - 0.24 11.6 12.5 0.38 11.0 0.0 5.5 4 2 0 4 4 4 0 FNIP Repeat F5_F8_type_C PF00754.25 EMC85974.1 - 2.2e-26 92.4 2.6 4.6e-26 91.4 2.6 1.5 1 0 0 1 1 1 1 F5/8 type C domain CUB PF00431.20 EMC85974.1 - 4.1e-19 68.9 0.3 1.4e-18 67.2 0.0 2.1 2 0 0 2 2 2 1 CUB domain LCCL PF03815.19 EMC85974.1 - 8.8e-15 54.6 0.2 2.1e-14 53.4 0.2 1.6 1 0 0 1 1 1 1 LCCL domain DUF3377 PF11857.8 EMC85974.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Pkinase_Tyr PF07714.17 EMC85975.1 - 3.4e-96 321.5 0.0 5.6e-96 320.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC85975.1 - 9.1e-41 140.0 0.0 1.6e-40 139.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 EMC85975.1 - 9.8e-40 134.8 36.1 3.3e-08 33.8 0.5 10.0 9 0 0 9 9 9 8 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 EMC85975.1 - 1.4 9.5 22.7 14 6.4 1.0 7.2 7 0 0 7 7 7 0 Purple acid Phosphatase, N-terminal domain Vg_Tdu PF07545.14 EMC85976.1 - 1.2e-19 69.7 0.5 2e-19 69.0 0.5 1.4 1 0 0 1 1 1 1 Vestigial/Tondu family RFX_DNA_binding PF02257.15 EMC85977.1 - 3.1e-31 107.8 0.1 1.1e-30 106.1 0.1 2.0 1 0 0 1 1 1 1 RFX DNA-binding domain RAG2_PHD PF13341.6 EMC85977.1 - 0.084 12.9 0.0 0.22 11.6 0.0 1.7 1 0 0 1 1 1 0 RAG2 PHD domain Pox_D5 PF03288.16 EMC85977.1 - 0.094 13.2 0.1 0.24 11.9 0.1 1.7 1 0 0 1 1 1 0 Poxvirus D5 protein-like ANF_receptor PF01094.28 EMC85978.1 - 1e-67 228.8 0.6 1.4e-67 228.3 0.6 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.22 EMC85978.1 - 7.6e-53 179.7 36.6 1.9e-52 178.3 36.6 1.8 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.14 EMC85978.1 - 2e-12 46.9 16.4 5.1e-12 45.6 16.4 1.8 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.6 EMC85978.1 - 4e-05 23.4 0.0 9.5e-05 22.2 0.0 1.6 1 1 0 1 1 1 1 Periplasmic binding protein DUF4501 PF14946.6 EMC85978.1 - 0.0083 16.2 6.0 0.0096 16.0 4.5 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4501) CoA_binding_2 PF13380.6 EMC85978.1 - 0.075 13.5 0.1 0.21 12.1 0.1 1.7 1 0 0 1 1 1 0 CoA binding domain DUF1075 PF06388.11 EMC85979.1 - 5e-40 136.3 0.6 6.7e-40 135.9 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1075) Arm PF00514.23 EMC85980.1 - 4e-91 296.6 15.9 7.7e-13 48.0 0.6 8.7 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 EMC85980.1 - 2.3e-27 95.3 1.7 5.5e-27 94.0 1.7 1.7 1 0 0 1 1 1 1 Importin beta binding domain HEAT_2 PF13646.6 EMC85980.1 - 1e-23 83.5 0.0 5.9e-07 29.8 0.0 5.0 3 1 1 5 5 4 4 HEAT repeats HEAT_EZ PF13513.6 EMC85980.1 - 6.6e-23 80.8 4.7 2.1e-07 31.3 0.0 6.1 4 2 1 5 5 5 4 HEAT-like repeat Arm_3 PF16186.5 EMC85980.1 - 8.9e-23 79.6 3.2 2.9e-22 78.0 2.5 2.3 3 0 0 3 3 3 1 Atypical Arm repeat HEAT PF02985.22 EMC85980.1 - 4.4e-19 66.9 4.7 0.00049 20.1 0.0 8.3 9 0 0 9 9 8 3 HEAT repeat V-ATPase_H_C PF11698.8 EMC85980.1 - 4.3e-06 26.8 0.0 0.13 12.4 0.0 4.5 3 3 2 5 5 5 2 V-ATPase subunit H RICTOR_V PF14668.6 EMC85980.1 - 6.1e-06 26.4 1.0 0.19 12.0 0.0 4.6 4 2 1 5 5 4 1 Rapamycin-insensitive companion of mTOR, domain 5 Arm_2 PF04826.13 EMC85980.1 - 9.9e-05 21.9 0.0 0.24 10.8 0.0 3.0 1 1 2 3 3 3 2 Armadillo-like Adaptin_N PF01602.20 EMC85980.1 - 0.00015 20.5 0.0 0.0035 16.0 0.0 2.4 1 1 1 2 2 2 2 Adaptin N terminal region V-ATPase_H_N PF03224.14 EMC85980.1 - 0.00038 19.8 0.1 0.29 10.4 0.0 3.6 2 2 1 3 3 3 1 V-ATPase subunit H HEAT_PBS PF03130.16 EMC85980.1 - 0.007 16.9 2.3 6.5 7.7 0.0 5.0 6 0 0 6 6 4 1 PBS lyase HEAT-like repeat NopRA1 PF16201.5 EMC85980.1 - 0.0078 15.8 0.0 6.9 6.2 0.0 3.7 1 1 2 4 4 4 1 Nucleolar pre-ribosomal-associated protein 1 Atx10homo_assoc PF09759.9 EMC85980.1 - 0.018 15.1 0.1 0.37 10.8 0.0 2.6 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain UNC45-central PF11701.8 EMC85980.1 - 0.045 13.7 0.0 0.91 9.5 0.0 2.6 2 1 0 2 2 2 0 Myosin-binding striated muscle assembly central CTNNBL PF08216.11 EMC85980.1 - 0.063 13.5 0.0 14 5.9 0.0 3.7 4 0 0 4 4 4 0 Catenin-beta-like, Arm-motif containing nuclear Big_5 PF13205.6 EMC85980.1 - 0.15 12.8 0.1 0.27 12.0 0.1 1.4 1 0 0 1 1 1 0 Bacterial Ig-like domain NUSAP PF16006.5 EMC85980.1 - 0.22 11.3 4.4 0.29 10.8 4.4 1.2 1 0 0 1 1 1 0 Nucleolar and spindle-associated protein Peptidase_C78 PF07910.13 EMC85981.1 - 2e-71 239.8 0.0 3.3e-71 239.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family C78 Peptidase_C54 PF03416.19 EMC85981.1 - 0.0013 18.3 0.0 0.0017 17.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family C54 DDRGK PF09756.9 EMC85981.1 - 0.041 13.5 6.6 0.02 14.5 4.5 1.5 2 0 0 2 2 2 0 DDRGK domain Zn-C2H2_12 PF18112.1 EMC85981.1 - 0.29 11.7 4.6 1.5 9.4 4.6 2.3 1 1 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain Sulfotransfer_1 PF00685.27 EMC85982.1 - 6.5e-76 255.3 0.4 7.6e-76 255.1 0.4 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC85982.1 - 7.9e-09 36.2 0.0 8.7e-05 23.0 0.0 2.3 2 0 0 2 2 2 2 Sulfotransferase family RWD PF05773.22 EMC85983.1 - 5.7e-27 94.3 2.3 5.7e-27 94.3 2.3 1.8 2 1 0 2 2 2 1 RWD domain DFRP_C PF16543.5 EMC85983.1 - 4.3e-06 27.1 10.2 4.3e-06 27.1 10.2 3.2 2 1 1 3 3 3 1 DRG Family Regulatory Proteins, Tma46 DUF445 PF04286.12 EMC85983.1 - 0.0082 16.0 8.3 0.0091 15.8 8.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF445) Folliculin PF11704.8 EMC85983.1 - 0.08 12.8 1.9 0.12 12.2 1.9 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport BUD22 PF09073.10 EMC85983.1 - 0.45 9.8 12.9 0.49 9.7 12.9 1.1 1 0 0 1 1 1 0 BUD22 DHHA1 PF02272.19 EMC85983.1 - 0.72 10.3 5.9 1.4 9.4 5.3 1.8 1 1 0 1 1 1 0 DHHA1 domain Ca_hom_mod PF14798.6 EMC85984.1 - 1.3e-84 283.3 2.4 1.5e-84 283.1 2.4 1.0 1 0 0 1 1 1 1 Calcium homeostasis modulator Wzy_C PF04932.15 EMC85984.1 - 0.31 10.7 3.5 2.1 7.9 0.0 2.5 2 1 0 2 2 2 0 O-Antigen ligase SNARE PF05739.19 EMC85984.1 - 0.34 10.9 1.6 1.2 9.1 0.0 2.4 2 0 0 2 2 2 0 SNARE domain DUF2093 PF09866.9 EMC85984.1 - 0.56 9.7 3.5 23 4.5 0.2 3.5 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2093) TRAPP PF04051.16 EMC85985.1 - 9.9e-31 106.4 0.0 1.1e-30 106.2 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Ca_hom_mod PF14798.6 EMC85986.1 - 2.3e-89 298.9 12.1 2.7e-89 298.6 12.1 1.1 1 0 0 1 1 1 1 Calcium homeostasis modulator Clc-like PF07062.12 EMC85986.1 - 0.12 11.9 0.0 0.12 11.9 0.0 2.4 4 0 0 4 4 4 0 Clc-like DUF5010_C PF18099.1 EMC85986.1 - 0.19 11.9 0.0 0.35 11.0 0.0 1.4 1 0 0 1 1 1 0 DUF5010 C-terminal domain OS-D PF03392.13 EMC85986.1 - 1.3 9.1 6.2 0.45 10.6 1.2 2.5 2 0 0 2 2 2 0 Insect pheromone-binding family, A10/OS-D Ca_hom_mod PF14798.6 EMC85987.1 - 2.5e-84 282.3 7.0 3e-84 282.1 7.0 1.0 1 0 0 1 1 1 1 Calcium homeostasis modulator DUF4962 PF16332.5 EMC85988.1 - 6.8e-07 28.2 4.2 6.8e-07 28.2 4.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4962) Hepar_II_III PF07940.13 EMC85988.1 - 0.057 13.0 0.0 3.9 7.0 0.0 2.3 2 0 0 2 2 2 0 Heparinase II/III-like protein DUF3340 PF11818.8 EMC85988.1 - 0.43 10.7 5.4 0.84 9.8 5.4 1.4 1 0 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) 5_nucleotid PF05761.14 EMC85989.1 - 2.2e-59 201.6 0.1 2.9e-59 201.2 0.1 1.0 1 0 0 1 1 1 1 5' nucleotidase family HAD_2 PF13419.6 EMC85989.1 - 0.00038 20.6 0.2 0.011 15.8 0.2 2.8 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Collagen PF01391.18 EMC85990.1 - 2.2e-68 225.9 288.9 4.3e-09 36.0 32.7 10.2 1 1 8 9 9 9 8 Collagen triple helix repeat (20 copies) C1q PF00386.21 EMC85990.1 - 8.6e-39 132.6 0.1 1.1e-38 132.3 0.1 1.1 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 EMC85990.1 - 0.0029 17.5 0.0 0.0045 16.9 0.0 1.1 1 0 0 1 1 1 1 BclA C-terminal domain Pkinase_Tyr PF07714.17 EMC85991.1 - 1.2e-95 319.7 0.0 1.5e-95 319.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC85991.1 - 1.2e-47 162.5 0.0 1.6e-47 162.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 EMC85991.1 - 6.3e-25 87.1 0.1 1.3e-24 86.0 0.1 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 EMC85991.1 - 1.4e-12 47.1 0.0 2.8e-12 46.0 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC85991.1 - 2.4e-09 36.9 0.2 7.4e-09 35.3 0.2 1.9 1 1 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC85991.1 - 9.7e-07 28.4 0.0 1.8e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain APH PF01636.23 EMC85991.1 - 0.032 14.2 0.0 3.5 7.5 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family B2 PF11473.8 EMC85991.1 - 0.058 13.2 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 RNA binding protein B2 Kdo PF06293.14 EMC85991.1 - 0.11 11.9 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EMC85991.1 - 0.13 11.6 0.0 0.18 11.1 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 EMC85991.1 - 0.15 10.9 0.0 0.35 9.8 0.0 1.6 1 1 0 1 1 1 0 Haspin like kinase domain VQ PF05678.14 EMC85992.1 - 0.00074 18.9 11.5 11 5.6 0.0 7.3 5 2 5 10 10 10 5 VQ motif DUF5504 PF17608.2 EMC85992.1 - 0.19 11.8 1.6 56 3.8 0.0 3.3 1 1 3 4 4 4 0 Family of unknown function (DUF5504) MinE PF03776.14 EMC85992.1 - 8.5 6.5 24.2 21 5.2 0.7 6.8 1 1 6 7 7 7 0 Septum formation topological specificity factor MinE SNF2_N PF00176.23 EMC85993.1 - 3.9e-23 81.7 0.1 4.2e-23 81.6 0.1 1.0 1 0 0 1 1 1 1 SNF2 family N-terminal domain SWI2_SNF2 PF18766.1 EMC85993.1 - 0.0017 18.1 0.0 0.0017 18.1 0.0 1.0 1 0 0 1 1 1 1 SWI2/SNF2 ATPase ResIII PF04851.15 EMC85993.1 - 0.0027 17.7 0.0 0.003 17.6 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EMC85993.1 - 0.026 14.3 0.0 0.028 14.2 0.0 1.1 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_22 PF13401.6 EMC85993.1 - 0.034 14.4 0.1 0.044 14.0 0.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EMC85993.1 - 0.052 13.9 0.0 0.058 13.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EMC85993.1 - 0.072 12.3 0.0 0.072 12.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) MSSP PF03940.13 EMC85994.1 - 8.5 6.1 6.5 0.51 10.0 0.4 2.2 4 0 0 4 4 4 0 Male specific sperm protein bZIP_1 PF00170.21 EMC85996.1 - 6e-15 55.1 16.0 1.3e-14 54.0 16.0 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMC85996.1 - 4.9e-09 36.1 10.8 4.9e-09 36.1 10.8 2.3 1 1 1 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 EMC85996.1 - 1.5e-06 28.6 10.7 3e-06 27.6 10.7 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor ZapB PF06005.12 EMC85996.1 - 0.0063 16.9 3.2 0.022 15.2 3.2 1.9 1 0 0 1 1 1 1 Cell division protein ZapB Fmp27_WPPW PF10359.9 EMC85996.1 - 0.0078 15.1 0.4 0.0098 14.8 0.4 1.2 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Goodbye PF17109.5 EMC85996.1 - 0.016 15.7 0.5 0.038 14.4 0.5 1.7 1 0 0 1 1 1 0 fungal STAND N-terminal Goodbye domain HAUS6_N PF14661.6 EMC85996.1 - 0.037 13.6 2.5 0.078 12.6 2.5 1.5 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus TPR_MLP1_2 PF07926.12 EMC85996.1 - 0.046 13.8 10.5 0.08 13.0 10.5 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N PF09744.9 EMC85996.1 - 0.051 13.8 7.5 0.096 12.9 7.5 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 FlaC_arch PF05377.11 EMC85996.1 - 0.051 14.0 2.0 0.14 12.6 2.0 1.7 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) HAUS-augmin3 PF14932.6 EMC85996.1 - 0.062 12.9 5.4 0.12 11.9 5.4 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 APG6_N PF17675.1 EMC85996.1 - 0.076 13.6 6.5 0.18 12.3 6.5 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region JMY PF15871.5 EMC85996.1 - 0.076 12.3 5.7 0.12 11.7 5.7 1.2 1 0 0 1 1 1 0 Junction-mediating and -regulatory protein ADIP PF11559.8 EMC85996.1 - 0.19 11.8 11.0 0.38 10.8 11.0 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF724 PF05266.14 EMC85996.1 - 0.22 11.3 7.0 0.38 10.6 7.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) FOXP-CC PF16159.5 EMC85996.1 - 0.24 12.1 1.7 0.59 10.8 1.7 1.7 1 0 0 1 1 1 0 FOXP coiled-coil domain TBCA PF02970.16 EMC85996.1 - 0.27 11.6 7.4 0.57 10.6 7.4 1.5 1 0 0 1 1 1 0 Tubulin binding cofactor A DUF4404 PF14357.6 EMC85996.1 - 0.66 10.7 5.0 1.2 9.8 2.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) DUF1664 PF07889.12 EMC85996.1 - 1 9.4 4.5 1.6 8.8 4.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Ribosomal_S7 PF00177.21 EMC85997.1 - 5.6e-20 71.5 0.5 5.3e-11 42.4 0.1 2.1 2 0 0 2 2 2 2 Ribosomal protein S7p/S5e 7tm_3 PF00003.22 EMC85999.1 - 3.1e-53 180.9 3.8 4.6e-53 180.4 3.8 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.28 EMC85999.1 - 8.3e-34 117.2 0.0 6.2e-28 97.9 0.0 2.1 2 0 0 2 2 2 2 Receptor family ligand binding region DUF3995 PF13160.6 EMC85999.1 - 0.0058 17.0 2.5 0.015 15.6 0.1 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3995) Kei1 PF08552.11 EMC85999.1 - 0.019 14.8 1.0 1.9 8.3 0.1 2.9 3 0 0 3 3 3 0 Inositolphosphorylceramide synthase subunit Kei1 LRRC37AB_C PF14914.6 EMC85999.1 - 0.045 13.7 0.3 2.5 8.0 0.0 2.6 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain Inhibitor_I71 PF12628.7 EMC85999.1 - 0.14 12.0 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 Falstatin, cysteine peptidase inhibitor TctB PF07331.11 EMC85999.1 - 0.3 11.3 14.2 11 6.3 1.1 3.4 1 1 1 2 2 2 0 Tripartite tricarboxylate transporter TctB family DUF1700 PF08006.11 EMC85999.1 - 5.8 6.4 9.0 1.3 8.5 0.4 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1700) Glyco_hydro_31 PF01055.26 EMC86000.1 - 3.7e-27 95.6 0.0 4.2e-27 95.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 zf-RING_12 PF17976.1 EMC86002.1 - 3e-39 133.1 5.1 9.8e-39 131.5 5.1 1.9 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_14 PF17978.1 EMC86002.1 - 8e-27 93.5 7.3 1.7e-26 92.5 7.3 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain ubiquitin PF00240.23 EMC86002.1 - 1.6e-19 69.4 0.0 2.4e-19 68.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EMC86002.1 - 2.9e-06 27.0 0.0 4.6e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 EMC86002.1 - 0.00088 19.4 0.0 0.0018 18.4 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EMC86002.1 - 0.0083 16.7 0.0 0.015 15.8 0.0 1.5 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Ubiquitin_5 PF18037.1 EMC86002.1 - 0.035 14.5 0.0 0.06 13.7 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-like domain ParcG PF10274.9 EMC86003.1 - 3.7e-74 248.8 0.3 1e-54 185.5 0.0 2.0 1 1 1 2 2 2 2 Parkin co-regulated protein Quaking_NLS PF16551.5 EMC86004.1 - 5.3e-17 61.2 4.9 9.2e-17 60.4 4.9 1.4 1 0 0 1 1 1 1 Putative nuclear localisation signal of quaking KH_1 PF00013.29 EMC86004.1 - 2.1e-06 27.5 0.0 4.5e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 KH domain STAR_dimer PF16544.5 EMC86004.1 - 0.00032 20.2 0.1 0.00062 19.3 0.1 1.5 1 0 0 1 1 1 1 Homodimerisation region of STAR domain protein PDEase_I PF00233.19 EMC86006.1 - 1.7e-72 244.0 0.7 3.4e-71 239.7 0.2 2.2 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.26 EMC86006.1 - 2.1e-29 102.8 0.0 2e-18 67.3 0.0 2.5 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.6 EMC86006.1 - 3.1e-19 69.6 0.0 8.2e-09 35.9 0.0 2.3 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.6 EMC86006.1 - 7.5e-09 36.0 0.0 1.7e-05 25.2 0.0 2.5 2 0 0 2 2 2 2 GAF domain SpoVT_C PF15714.5 EMC86006.1 - 8e-06 25.9 0.0 0.0031 17.6 0.0 2.7 3 0 0 3 3 3 2 Stage V sporulation protein T C-terminal, transcription factor HD PF01966.22 EMC86006.1 - 0.037 14.2 0.2 0.084 13.1 0.2 1.6 1 0 0 1 1 1 0 HD domain H_kinase_N PF12282.8 EMC86006.1 - 0.078 12.9 0.0 0.21 11.5 0.0 1.8 1 0 0 1 1 1 0 Signal transduction histidine kinase DUF4748 PF15932.5 EMC86006.1 - 0.18 11.6 0.0 0.41 10.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4748) Got1 PF04178.12 EMC86007.1 - 2.8e-36 124.4 16.7 2.8e-36 124.4 16.7 1.9 1 1 1 2 2 2 2 Got1/Sft2-like family DUF4064 PF13273.6 EMC86007.1 - 0.0022 18.2 9.1 0.034 14.4 2.1 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF4064) Bac_export_2 PF01312.19 EMC86007.1 - 0.3 10.2 5.2 1.2 8.3 5.2 1.8 1 1 0 1 1 1 0 FlhB HrpN YscU SpaS Family DUF4293 PF14126.6 EMC86007.1 - 0.62 10.3 7.8 1.1 9.4 7.3 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4293) FtsX PF02687.21 EMC86007.1 - 0.76 10.3 13.0 0.043 14.3 6.1 2.0 1 1 1 2 2 2 0 FtsX-like permease family MPC PF03650.13 EMC86009.1 - 9.2e-33 112.7 0.1 1.1e-32 112.4 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Ribonuclease_T2 PF00445.18 EMC86010.1 - 5.3e-56 189.7 8.6 6.6e-56 189.4 8.6 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family FOP_dimer PF09398.10 EMC86011.1 - 4.5e-28 97.3 1.2 1.5e-27 95.6 0.0 2.5 3 0 0 3 3 3 1 FOP N terminal dimerisation domain LisH_2 PF16045.5 EMC86011.1 - 1.8e-07 30.1 0.3 6.3e-07 28.3 0.0 1.9 2 0 0 2 2 2 1 LisH Mcm10 PF09332.11 EMC86011.1 - 6.1 6.2 7.4 0.72 9.2 0.7 2.1 2 0 0 2 2 2 0 Mcm10 replication factor 7tm_1 PF00001.21 EMC86012.1 - 2.6e-48 164.7 21.8 3.3e-48 164.3 21.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC86012.1 - 0.00027 20.4 27.7 0.00038 19.9 27.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx PEN-2 PF10251.9 EMC86012.1 - 0.33 11.4 10.1 1 9.8 0.2 3.1 3 1 1 4 4 4 0 Presenilin enhancer-2 subunit of gamma secretase Ctr PF04145.15 EMC86012.1 - 4.7 7.8 9.0 0.29 11.7 0.2 2.9 4 0 0 4 4 4 0 Ctr copper transporter family CitMHS PF03600.16 EMC86012.1 - 6.1 5.9 11.1 12 4.9 11.1 1.5 1 1 0 1 1 1 0 Citrate transporter TBK1_CCD1 PF18394.1 EMC86013.1 - 0.025 14.2 0.4 0.026 14.1 0.4 1.0 1 0 0 1 1 1 0 TANK-binding kinase 1 coiled-coil domain 1 Tcp10_C PF07202.13 EMC86014.1 - 2e-87 291.7 7.3 2.3e-87 291.5 7.3 1.0 1 0 0 1 1 1 1 T-complex protein 10 C-terminus DUF4520 PF15016.6 EMC86014.1 - 0.015 15.4 0.2 1.2 9.2 0.0 3.3 1 1 3 4 4 4 0 Domain of unknown function (DUF4520) TTL PF03133.15 EMC86015.1 - 6e-78 262.0 0.1 8.8e-78 261.4 0.1 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EMC86015.1 - 1e-05 24.9 0.1 0.00024 20.5 0.0 2.5 2 1 0 2 2 2 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 EMC86015.1 - 0.00032 20.0 0.0 0.014 14.7 0.0 2.2 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp UNC-93 PF05978.16 EMC86016.1 - 3.9e-11 42.9 10.2 3.9e-11 42.9 10.2 3.5 2 2 1 3 3 3 2 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 EMC86016.1 - 0.00013 21.1 34.2 0.098 11.6 15.5 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily RA PF00788.23 EMC86017.1 - 9.2e-47 157.6 0.0 1.5e-23 83.2 0.0 3.0 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain DIL PF01843.19 EMC86017.1 - 1.8e-30 105.3 1.5 1.8e-30 105.3 1.5 2.2 2 0 0 2 2 2 1 DIL domain PDZ PF00595.24 EMC86017.1 - 4.9e-17 62.1 0.6 1.1e-16 60.9 0.6 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC86017.1 - 2.4e-08 33.7 0.4 5.4e-08 32.6 0.4 1.7 1 0 0 1 1 1 1 PDZ domain FHA PF00498.26 EMC86017.1 - 1.8e-06 28.2 0.0 4.4e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 FHA domain PDZ_2 PF13180.6 EMC86017.1 - 5.1e-05 23.5 0.4 0.00018 21.8 0.4 1.9 1 0 0 1 1 1 1 PDZ domain Yop-YscD_cpl PF16697.5 EMC86017.1 - 0.01 16.1 0.0 0.031 14.6 0.0 1.9 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain DUF4477 PF14780.6 EMC86017.1 - 0.064 12.9 0.1 0.24 11.0 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4477) FERM_M PF00373.18 EMC86018.1 - 7.1e-21 74.8 0.5 7.1e-21 74.8 0.5 1.8 2 0 0 2 2 2 1 FERM central domain FERM_C PF09380.10 EMC86018.1 - 5e-16 58.9 0.0 1.2e-15 57.7 0.0 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.10 EMC86018.1 - 1.5e-12 47.3 0.0 3.3e-12 46.2 0.0 1.6 1 0 0 1 1 1 1 FERM N-terminal domain Dapper PF15268.6 EMC86019.1 - 4.3e-229 763.5 38.6 1.9e-225 751.5 38.6 2.0 1 1 0 1 1 1 1 Dapper Sulfotransfer_1 PF00685.27 EMC86020.1 - 4.6e-66 223.0 0.4 5.5e-66 222.8 0.4 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC86020.1 - 5e-11 43.4 0.0 9.8e-08 32.6 0.0 2.3 1 1 1 2 2 2 2 Sulfotransferase family Thyroglobulin_1 PF00086.18 EMC86021.1 - 1.2e-37 127.4 18.8 3.2e-19 68.4 4.5 3.0 2 0 0 2 2 2 2 Thyroglobulin type-1 repeat Thyroglob_assoc PF16597.5 EMC86021.1 - 6.9e-28 96.8 3.2 1.6e-27 95.6 3.2 1.6 1 0 0 1 1 1 1 Thyroglobulin_1 repeat associated disordered domain SPARC_Ca_bdg PF10591.9 EMC86021.1 - 1.6e-11 44.5 1.3 3.2e-11 43.5 0.1 2.1 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Kazal_2 PF07648.15 EMC86021.1 - 1.9e-07 31.1 4.2 1.9e-07 31.1 4.2 2.3 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain EF-hand_7 PF13499.6 EMC86021.1 - 9.9e-06 25.9 0.1 0.00013 22.3 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EMC86021.1 - 6.5e-05 22.2 0.2 1.4 8.6 0.0 3.6 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 EMC86021.1 - 0.00015 21.4 0.3 1.5 8.9 0.1 3.3 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 EMC86021.1 - 0.02 14.4 2.0 0.13 11.8 0.0 3.2 4 0 0 4 4 4 0 EF hand TSP_C PF05735.12 EMC86022.1 - 9.2e-97 322.7 1.4 1.3e-96 322.2 1.4 1.2 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.18 EMC86022.1 - 8.8e-58 191.7 138.0 8e-12 44.6 15.4 10.4 8 2 2 10 10 10 8 Thrombospondin type 3 repeat TSP_1 PF00090.19 EMC86022.1 - 1.1e-43 147.2 62.9 7.6e-17 61.3 9.0 5.3 5 0 0 5 5 5 3 Thrombospondin type 1 domain VWC PF00093.18 EMC86022.1 - 1.8e-12 47.4 17.1 1.8e-12 47.4 17.1 6.2 5 1 1 6 6 6 1 von Willebrand factor type C domain EGF_3 PF12947.7 EMC86022.1 - 2.7e-07 30.7 7.2 2.7e-07 30.7 7.2 5.7 6 0 0 6 6 6 2 EGF domain EGF_CA PF07645.15 EMC86022.1 - 5.1e-06 26.6 1.7 5.1e-06 26.6 1.7 5.3 4 0 0 4 4 4 2 Calcium-binding EGF domain Laminin_G_3 PF13385.6 EMC86022.1 - 0.0029 17.8 1.0 0.36 11.0 0.0 2.3 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.27 EMC86022.1 - 0.0034 17.7 8.3 0.0034 17.7 8.3 5.0 5 0 0 5 5 5 1 EGF-like domain cEGF PF12662.7 EMC86022.1 - 0.038 13.9 0.6 0.038 13.9 0.6 4.8 5 0 0 5 5 5 0 Complement Clr-like EGF-like Laminin_G_2 PF02210.24 EMC86022.1 - 0.14 12.8 0.0 0.27 11.8 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain WD40 PF00400.32 EMC86023.1 - 3.1e-16 59.5 3.9 5.5e-07 30.2 1.6 7.6 8 0 0 8 8 8 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC86023.1 - 6.3e-07 29.6 0.6 0.0062 16.8 0.1 4.3 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMC86023.1 - 0.00029 19.6 0.8 0.12 11.0 0.1 3.6 3 1 0 3 3 3 2 Nucleoporin Nup120/160 Frtz PF11768.8 EMC86023.1 - 0.051 11.9 0.0 0.11 10.7 0.0 1.5 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz UPF0669 PF17065.5 EMC86024.1 - 6.7e-109 361.7 0.3 7.4e-109 361.6 0.3 1.0 1 0 0 1 1 1 1 Putative cytokine, C6ORF120 PHD PF00628.29 EMC86025.1 - 5e-17 61.5 24.5 1.7e-08 34.3 10.4 2.4 1 1 1 2 2 2 2 PHD-finger PHD_4 PF16866.5 EMC86025.1 - 0.001 19.1 9.5 0.001 19.1 9.5 3.3 1 1 1 2 2 2 1 PHD-finger PHD_2 PF13831.6 EMC86025.1 - 0.018 14.6 4.5 0.018 14.6 4.5 2.7 2 1 0 2 2 2 0 PHD-finger Herpes_MCP PF03122.14 EMC86025.1 - 0.036 11.5 0.2 0.048 11.1 0.2 1.0 1 0 0 1 1 1 0 Herpes virus major capsid protein zf-PHD-like PF15446.6 EMC86025.1 - 3.5 7.2 17.4 1.8 8.1 3.6 3.0 2 1 1 3 3 3 0 PHD/FYVE-zinc-finger like domain Tctex-1 PF03645.13 EMC86026.1 - 1.5e-23 83.0 0.3 1.8e-23 82.8 0.3 1.0 1 0 0 1 1 1 1 Tctex-1 family DUF4209 PF13910.6 EMC86027.1 - 8.2e-29 99.7 0.1 2.6e-23 82.1 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4209) PRF PF06875.11 EMC86027.1 - 0.13 11.7 0.3 1 8.7 0.2 2.2 2 0 0 2 2 2 0 Plethodontid receptivity factor PRF Proteasome PF00227.26 EMC86029.1 - 5e-39 133.8 0.0 6.4e-39 133.4 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Cytochrom_C1 PF02167.15 EMC86029.1 - 0.0011 18.7 0.1 0.0016 18.2 0.1 1.2 1 0 0 1 1 1 1 Cytochrome C1 family TBP PF00352.21 EMC86030.1 - 3e-63 209.8 0.4 3.3e-32 110.3 0.1 2.2 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EMC86030.1 - 0.00069 19.7 0.6 1.5 9.0 0.0 2.8 3 0 0 3 3 3 2 Domain of unknown function (DUF3378) TFIIA PF03153.13 EMC86030.1 - 0.071 13.1 4.8 0.074 13.0 4.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SPATA3 PF15662.5 EMC86030.1 - 1.4 9.5 6.3 2.2 8.9 6.3 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated protein 3 family PDCD2_C PF04194.13 EMC86031.1 - 1.5e-38 132.6 0.1 2e-38 132.2 0.1 1.2 1 0 0 1 1 1 1 Programmed cell death protein 2, C-terminal putative domain Acyltransferase PF01553.21 EMC86032.1 - 4.5e-24 84.6 0.0 8.2e-24 83.8 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase DUF4602 PF15375.6 EMC86033.1 - 2.3e-20 73.3 14.6 2.5e-20 73.2 14.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4602) Med19 PF10278.9 EMC86033.1 - 4.3 7.2 16.5 5.1 7.0 16.5 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 SPRY PF00622.28 EMC86034.1 - 1.6e-11 44.4 0.0 2.5e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 SPRY domain fn3 PF00041.21 EMC86034.1 - 9.1e-09 35.5 0.0 2e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III domain zf-B_box PF00643.24 EMC86034.1 - 2e-07 31.0 3.6 5.4e-07 29.7 3.6 1.8 1 0 0 1 1 1 1 B-box zinc finger PRY PF13765.6 EMC86034.1 - 1.5e-05 24.6 0.1 3.4e-05 23.4 0.1 1.6 1 0 0 1 1 1 1 SPRY-associated domain Laminin_G_3 PF13385.6 EMC86034.1 - 0.013 15.7 0.4 0.04 14.1 0.1 1.9 2 0 0 2 2 2 0 Concanavalin A-like lectin/glucanases superfamily zf-UBR PF02207.20 EMC86034.1 - 0.023 14.8 2.6 0.067 13.4 2.6 1.7 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) DUF1281 PF06924.11 EMC86034.1 - 0.11 12.0 0.4 0.19 11.2 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1281) Arv1 PF04161.13 EMC86035.1 - 6.5e-49 166.9 4.2 7.6e-49 166.7 4.2 1.0 1 0 0 1 1 1 1 Arv1-like family PIRT PF15099.6 EMC86035.1 - 0.12 11.9 0.3 0.23 11.1 0.3 1.3 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family TPR_1 PF00515.28 EMC86036.1 - 3.3e-29 99.5 21.1 4.1e-08 32.7 0.7 9.1 9 1 1 10 10 10 6 Tetratricopeptide repeat TPR_2 PF07719.17 EMC86036.1 - 3.8e-29 98.4 12.5 7.6e-06 25.6 0.6 8.9 8 2 1 9 9 8 6 Tetratricopeptide repeat TPR_11 PF13414.6 EMC86036.1 - 4.6e-24 83.8 2.9 4.1e-07 29.6 0.1 7.5 4 1 3 7 7 7 6 TPR repeat TPR_8 PF13181.6 EMC86036.1 - 1.2e-20 71.9 6.2 0.00027 20.9 0.2 8.6 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_19 PF14559.6 EMC86036.1 - 5.7e-18 65.2 3.3 1.1e-05 25.8 0.6 5.4 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 EMC86036.1 - 2.2e-17 63.4 0.1 6.8e-05 23.4 0.0 4.7 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 EMC86036.1 - 1.1e-16 60.7 0.8 9.3e-05 22.5 0.1 5.6 1 1 5 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 EMC86036.1 - 3.2e-15 55.5 5.4 0.14 13.0 0.1 7.8 2 1 6 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 EMC86036.1 - 1.8e-14 53.8 11.4 2.9e-06 27.5 1.2 5.4 4 2 1 5 5 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 EMC86036.1 - 1.5e-13 50.1 0.6 0.87 10.1 0.1 7.2 7 1 0 7 7 7 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC86036.1 - 4.3e-07 30.1 7.1 0.0028 17.8 1.4 4.8 2 1 2 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EMC86036.1 - 7.7e-06 25.6 3.4 0.012 15.6 0.2 5.2 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_10 PF13374.6 EMC86036.1 - 0.00015 21.5 5.4 0.12 12.3 0.2 5.3 5 1 1 6 6 6 1 Tetratricopeptide repeat NARP1 PF12569.8 EMC86036.1 - 0.00023 20.2 0.6 0.082 11.8 0.3 2.4 2 0 0 2 2 2 2 NMDA receptor-regulated protein 1 TPR_6 PF13174.6 EMC86036.1 - 0.00032 21.1 5.6 18 6.2 0.1 6.6 7 0 0 7 7 7 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 EMC86036.1 - 0.00042 19.7 10.6 0.64 9.5 0.2 4.9 5 0 0 5 5 5 1 SHNi-TPR TPR_MalT PF17874.1 EMC86036.1 - 0.00049 19.6 2.4 0.032 13.6 0.6 3.5 1 1 3 4 4 4 2 MalT-like TPR region TPR_21 PF09976.9 EMC86036.1 - 0.0011 18.8 0.3 0.58 9.8 0.0 2.8 1 1 0 2 2 2 1 Tetratricopeptide repeat-like domain BTAD PF03704.17 EMC86036.1 - 0.0093 16.4 0.5 2.7 8.4 0.0 2.8 1 1 1 2 2 2 1 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.6 EMC86036.1 - 0.011 15.7 1.9 9.2 6.4 0.1 3.6 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat FAT PF02259.23 EMC86036.1 - 0.072 12.3 0.8 0.13 11.5 0.8 1.3 1 0 0 1 1 1 0 FAT domain Rapsyn_N PF10579.9 EMC86036.1 - 0.14 12.3 1.0 4.9 7.3 0.0 2.7 2 0 0 2 2 2 0 Rapsyn N-terminal myristoylation and linker region Peptidase_C2 PF00648.21 EMC86038.1 - 5.8e-131 435.9 0.0 9.8e-131 435.2 0.0 1.4 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 EMC86038.1 - 3e-49 166.9 0.0 5.2e-49 166.1 0.0 1.4 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_1 PF00036.32 EMC86038.1 - 5.9e-10 38.0 2.9 0.00041 19.7 0.1 3.9 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 EMC86038.1 - 2e-09 36.6 1.2 0.0005 19.8 0.0 4.0 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 EMC86038.1 - 1.8e-07 30.9 0.6 2.9e-05 23.8 0.1 3.4 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.6 EMC86038.1 - 0.00034 21.0 3.3 0.35 11.4 0.3 3.5 2 1 0 2 2 2 2 EF-hand domain pair Ndufs5 PF10200.9 EMC86038.1 - 0.031 14.5 0.2 0.55 10.5 0.0 2.8 3 0 0 3 3 3 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa Serpin PF00079.20 EMC86039.1 - 1.7e-60 205.3 0.0 2.2e-60 204.9 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DDE_Tnp_1_7 PF13843.6 EMC86040.1 - 2.5e-83 280.3 0.3 2.9e-83 280.1 0.3 1.0 1 0 0 1 1 1 1 Transposase IS4 HEPN PF05168.14 EMC86040.1 - 0.043 13.9 0.0 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 HEPN domain WD40 PF00400.32 EMC86041.1 - 1.3e-53 177.8 8.0 2.6e-10 40.7 0.1 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 EMC86041.1 - 8.1e-31 107.0 3.9 1.4e-30 106.2 3.9 1.3 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 EMC86041.1 - 7.6e-12 45.4 0.0 0.013 15.8 0.0 4.5 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMC86041.1 - 6e-05 21.9 0.5 0.5 8.9 0.1 3.4 1 1 1 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 EMC86041.1 - 0.00062 19.2 0.0 6.1 6.1 0.0 3.3 1 1 2 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.5 EMC86041.1 - 0.00076 18.5 0.0 0.15 11.0 0.0 3.4 2 2 3 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EMC86041.1 - 0.0022 17.9 0.0 0.019 14.9 0.0 2.4 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 EMC86041.1 - 0.09 12.1 0.0 0.5 9.7 0.0 2.1 2 1 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal ABC_membrane PF00664.23 EMC86042.1 - 2.2e-59 201.4 4.7 3.1e-59 200.9 4.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EMC86042.1 - 1.3e-33 116.4 0.0 3e-33 115.3 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EMC86042.1 - 1.4e-07 31.2 0.1 5.2e-05 22.8 0.0 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA PF00004.29 EMC86042.1 - 0.00062 20.2 0.1 0.0089 16.4 0.1 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EMC86042.1 - 0.00085 19.7 0.4 0.0034 17.8 0.4 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EMC86042.1 - 0.0023 18.2 0.3 0.017 15.4 0.3 2.2 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EMC86042.1 - 0.0025 17.5 0.1 0.0052 16.5 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_ATPase PF09818.9 EMC86042.1 - 0.0048 15.8 0.0 0.12 11.2 0.0 2.1 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_21 PF13304.6 EMC86042.1 - 0.012 15.5 0.2 0.16 11.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 EMC86042.1 - 0.012 15.2 0.0 0.031 13.9 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EMC86042.1 - 0.013 15.5 0.2 0.092 12.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 EMC86042.1 - 0.025 14.5 0.1 0.064 13.2 0.1 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_30 PF13604.6 EMC86042.1 - 0.035 13.8 0.1 0.13 12.0 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EMC86042.1 - 0.078 12.5 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 EMC86042.1 - 0.085 13.0 0.0 0.62 10.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 EMC86042.1 - 0.15 11.7 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 EMC86042.1 - 0.16 12.5 0.0 0.49 10.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain Nucleoporin_C PF03177.14 EMC86043.1 - 6.6e-26 91.2 14.2 2.2e-25 89.5 11.2 2.7 1 1 1 2 2 2 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.11 EMC86043.1 - 3.7e-10 39.1 0.7 6e-10 38.4 0.7 1.2 1 0 0 1 1 1 1 Nup133 N terminal like Actin PF00022.19 EMC86044.1 - 1.7e-124 415.6 0.0 6.3e-124 413.7 0.0 1.7 1 1 0 1 1 1 1 Actin CCSAP PF15748.5 EMC86046.1 - 1.1e-52 179.8 23.8 1.2e-52 179.6 23.8 1.0 1 0 0 1 1 1 1 Centriole, cilia and spindle-associated MAP7 PF05672.11 EMC86046.1 - 9.7 5.9 24.8 20 4.8 24.8 1.5 1 1 0 1 1 1 0 MAP7 (E-MAP-115) family Ras PF00071.22 EMC86047.1 - 4.8e-59 198.6 0.2 5.6e-59 198.4 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC86047.1 - 5.4e-33 113.8 0.1 7.6e-33 113.3 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC86047.1 - 5.7e-14 52.0 0.0 7.7e-14 51.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC86047.1 - 8.1e-06 25.5 0.1 0.0004 20.0 0.1 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EMC86047.1 - 0.00015 21.9 0.0 0.00022 21.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMC86047.1 - 0.0013 18.2 0.0 0.0016 17.8 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EMC86047.1 - 0.0029 17.5 0.1 1 9.2 0.1 2.3 2 1 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 EMC86047.1 - 0.0032 16.9 0.0 0.0053 16.2 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 EMC86047.1 - 0.0085 15.6 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region PduV-EutP PF10662.9 EMC86047.1 - 0.014 15.2 0.1 0.039 13.7 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 EMC86047.1 - 0.034 14.4 0.1 0.21 11.8 0.1 2.2 1 1 1 2 2 2 0 AAA domain AAA_16 PF13191.6 EMC86047.1 - 0.04 14.3 0.1 0.068 13.6 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 EMC86047.1 - 0.051 12.9 0.0 0.071 12.4 0.0 1.2 1 0 0 1 1 1 0 Septin ATP_bind_1 PF03029.17 EMC86047.1 - 0.057 13.2 0.0 3.8 7.2 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein ATPase PF06745.13 EMC86047.1 - 0.073 12.4 0.1 0.15 11.4 0.1 1.5 1 0 0 1 1 1 0 KaiC ATPase_2 PF01637.18 EMC86047.1 - 0.098 12.5 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DUF2075 PF09848.9 EMC86047.1 - 0.1 11.8 0.0 0.19 10.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 EMC86047.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Ras PF00071.22 EMC86048.1 - 5.2e-35 120.4 0.0 6.5e-35 120.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC86048.1 - 1.4e-12 47.9 0.0 2.9e-12 46.9 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Lipase_GDSL_3 PF14606.6 EMC86048.1 - 0.0027 17.8 0.0 0.0037 17.4 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family GTP_EFTU PF00009.27 EMC86048.1 - 0.08 12.5 0.0 0.19 11.2 0.0 1.5 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain SLBP_RNA_bind PF15247.6 EMC86048.1 - 0.13 12.4 1.7 0.24 11.5 0.5 1.9 2 0 0 2 2 2 0 Histone RNA hairpin-binding protein RNA-binding domain Abhydrolase_2 PF02230.16 EMC86048.1 - 0.17 11.6 0.0 0.25 11.1 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase SprT-like PF10263.9 EMC86049.1 - 3.3e-21 75.2 0.0 8.3e-21 74.0 0.0 1.7 1 0 0 1 1 1 1 SprT-like family RNF220 PF15926.5 EMC86049.1 - 0.0068 16.1 2.1 0.0068 16.1 2.1 1.7 2 0 0 2 2 2 1 E3 ubiquitin-protein ligase RNF220 zf-WRNIP1_ubi PF18279.1 EMC86049.1 - 0.034 14.8 0.1 0.11 13.2 0.1 1.9 1 0 0 1 1 1 0 Werner helicase-interacting protein 1 ubiquitin-binding domain Aminopep PF10023.9 EMC86049.1 - 0.094 12.1 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Putative aminopeptidase PRP21_like_P PF12230.8 EMC86049.1 - 0.36 10.7 9.4 0.018 14.9 2.9 2.1 2 0 0 2 2 2 0 Pre-mRNA splicing factor PRP21 like protein Translin PF01997.16 EMC86050.1 - 1.6e-61 207.9 0.2 2e-61 207.6 0.2 1.1 1 0 0 1 1 1 1 Translin family Laminin_II PF06009.12 EMC86051.1 - 0.0026 17.8 0.4 0.0026 17.8 0.4 4.5 3 2 1 5 5 5 1 Laminin Domain II UVR PF02151.19 EMC86051.1 - 0.012 15.4 7.7 0.012 15.4 7.7 3.1 2 0 0 2 2 2 0 UvrB/uvrC motif TMF_DNA_bd PF12329.8 EMC86051.1 - 0.27 11.2 0.1 0.27 11.2 0.1 5.9 5 2 1 6 6 6 0 TATA element modulatory factor 1 DNA binding Baculo_PEP_C PF04513.12 EMC86051.1 - 0.48 10.5 10.8 2.8 8.0 0.1 4.4 3 1 2 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus Pox_A_type_inc PF04508.12 EMC86051.1 - 2.6 8.0 0.0 2.6 8.0 0.0 4.9 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat SPAR_C PF11881.8 EMC86052.1 - 8.4e-70 235.4 0.1 2.9e-69 233.7 0.1 1.9 1 0 0 1 1 1 1 C-terminal domain of SPAR protein Rap_GAP PF02145.15 EMC86052.1 - 5.1e-67 225.0 0.0 1e-66 224.0 0.0 1.6 1 0 0 1 1 1 1 Rap/ran-GAP PDZ_6 PF17820.1 EMC86052.1 - 1.6e-05 24.7 0.0 3.3e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 EMC86052.1 - 2.5e-05 24.5 0.0 4.8e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain bZIP_2 PF07716.15 EMC86052.1 - 0.38 10.9 4.8 1.5 9.0 4.8 2.0 1 0 0 1 1 1 0 Basic region leucine zipper DivIC PF04977.15 EMC86052.1 - 6 6.7 5.5 13 5.6 5.5 1.5 1 0 0 1 1 1 0 Septum formation initiator HPHLAWLY PF14925.6 EMC86053.1 - 8.1e-81 272.6 29.0 2.2e-80 271.1 29.0 1.6 1 1 0 1 1 1 1 Domain of unknown function NTPase_1 PF03266.15 EMC86054.1 - 1.3e-60 204.1 0.5 1.5e-60 204.0 0.5 1.0 1 0 0 1 1 1 1 NTPase AAA_30 PF13604.6 EMC86054.1 - 0.0091 15.7 0.5 0.032 14.0 0.5 1.9 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EMC86054.1 - 0.033 14.5 0.2 0.34 11.2 0.1 2.5 1 1 1 2 2 2 0 AAA domain AAA_14 PF13173.6 EMC86054.1 - 0.041 13.9 0.0 5.2 7.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EMC86054.1 - 0.048 14.1 0.1 0.25 11.7 0.1 2.0 1 1 0 1 1 1 0 AAA ATPase domain MobB PF03205.14 EMC86054.1 - 0.072 13.0 0.1 0.16 11.9 0.1 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B ACT PF01842.25 EMC86054.1 - 0.09 12.6 0.1 0.31 10.9 0.0 2.0 2 1 0 2 2 2 0 ACT domain AAA PF00004.29 EMC86054.1 - 0.1 13.0 0.2 0.36 11.3 0.2 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Pecanex_C PF05041.15 EMC86055.1 - 2e-114 380.9 0.0 3.1e-114 380.3 0.0 1.3 1 0 0 1 1 1 1 Pecanex protein (C-terminus) PRRSV_2b PF07069.11 EMC86055.1 - 0.15 12.6 1.4 0.8 10.3 1.4 2.3 1 0 0 1 1 1 0 Porcine reproductive and respiratory syndrome virus 2b Pkinase_Tyr PF07714.17 EMC86056.1 - 1.6e-31 109.5 0.0 3.2e-31 108.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC86056.1 - 3.7e-26 92.0 0.0 8.7e-26 90.8 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain DUF3552 PF12072.8 EMC86056.1 - 0.2 11.1 14.6 0.36 10.2 14.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) OmpH PF03938.14 EMC86056.1 - 1.6 9.1 10.8 4.6 7.6 10.8 1.8 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF3450 PF11932.8 EMC86056.1 - 3.5 6.9 10.8 6.4 6.0 10.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) EamA PF00892.20 EMC86057.1 - 1.1e-07 32.0 8.5 1.1e-07 32.0 8.5 2.7 2 1 0 2 2 2 2 EamA-like transporter family SLC35F PF06027.12 EMC86057.1 - 2.3e-05 24.1 24.1 3.4e-05 23.5 24.1 1.2 1 0 0 1 1 1 1 Solute carrier family 35 COX6B PF02297.17 EMC86058.1 - 2.1e-09 37.5 4.1 4.7e-09 36.4 4.1 1.5 1 1 0 1 1 1 1 Cytochrome oxidase c subunit VIb SpoU_methylase PF00588.19 EMC86059.1 - 2.4e-29 102.3 0.0 6.2e-29 101.0 0.0 1.8 1 0 0 1 1 1 1 SpoU rRNA Methylase family MAS20 PF02064.15 EMC86060.1 - 1.7e-27 96.0 0.4 2e-27 95.8 0.4 1.1 1 0 0 1 1 1 1 MAS20 protein import receptor RSN1_7TM PF02714.15 EMC86060.1 - 0.013 14.8 0.0 0.015 14.6 0.0 1.1 1 0 0 1 1 1 0 Calcium-dependent channel, 7TM region, putative phosphate TPR_1 PF00515.28 EMC86060.1 - 0.054 13.3 0.1 0.095 12.6 0.1 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 EMC86060.1 - 0.071 14.0 0.1 0.25 12.3 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EMC86060.1 - 0.11 12.6 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat RRM_1 PF00076.22 EMC86061.1 - 6.3e-30 102.8 1.0 2.4e-15 56.1 0.0 3.1 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMC86061.1 - 2.9e-10 40.1 0.1 0.00021 21.4 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EMC86061.1 - 0.00015 21.7 0.1 0.013 15.5 0.0 2.6 2 1 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.13 EMC86061.1 - 0.0012 18.8 0.1 0.87 9.6 0.1 2.3 1 1 1 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_Rrp7 PF17799.1 EMC86061.1 - 0.0073 16.1 0.0 0.21 11.4 0.0 2.1 2 0 0 2 2 2 1 Rrp7 RRM-like N-terminal domain DUF1866 PF08952.11 EMC86061.1 - 0.018 14.9 0.0 0.62 9.9 0.0 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF1866) Spo7_2_N PF15407.6 EMC86061.1 - 0.075 12.7 0.0 2.1 8.1 0.0 2.3 2 0 0 2 2 2 0 Sporulation protein family 7 polyprenyl_synt PF00348.17 EMC86062.1 - 1.4e-60 204.5 0.0 3.2e-60 203.4 0.0 1.6 1 1 0 1 1 1 1 Polyprenyl synthetase Galactosyl_T PF01762.21 EMC86063.1 - 7.8e-28 97.6 0.0 4e-25 88.8 0.0 2.2 2 0 0 2 2 2 2 Galactosyltransferase Fringe PF02434.16 EMC86063.1 - 0.023 14.1 0.2 0.76 9.2 0.0 2.3 2 0 0 2 2 2 0 Fringe-like G-gamma PF00631.22 EMC86064.1 - 2.3e-16 59.6 0.0 2.6e-16 59.4 0.0 1.1 1 0 0 1 1 1 1 GGL domain Beach PF02138.18 EMC86065.1 - 6.8e-28 97.8 0.1 1.2e-27 97.0 0.1 1.4 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 EMC86065.1 - 1.1e-22 80.0 0.0 2.8e-22 78.7 0.0 1.7 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH DUF4800 PF16057.5 EMC86065.1 - 0.076 12.3 2.5 0.2 10.9 2.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4800) G2F PF07474.12 EMC86066.1 - 2.2e-72 242.7 0.3 4.1e-72 241.8 0.3 1.5 1 0 0 1 1 1 1 G2F domain Ldl_recept_b PF00058.17 EMC86066.1 - 4.8e-38 129.4 3.6 3.7e-11 43.3 0.1 4.7 4 0 0 4 4 4 3 Low-density lipoprotein receptor repeat class B EGF_3 PF12947.7 EMC86066.1 - 1.4e-31 108.3 103.0 4.2e-09 36.4 10.3 6.5 6 0 0 6 6 6 5 EGF domain NIDO PF06119.14 EMC86066.1 - 5.5e-22 78.5 0.7 1.9e-21 76.8 0.7 2.0 1 0 0 1 1 1 1 Nidogen-like EGF_CA PF07645.15 EMC86066.1 - 1.9e-20 72.8 94.1 3.4e-09 36.7 9.3 6.9 6 0 0 6 6 5 5 Calcium-binding EGF domain cEGF PF12662.7 EMC86066.1 - 5.9e-19 67.7 49.1 3.7e-07 29.9 1.4 6.7 6 0 0 6 6 6 5 Complement Clr-like EGF-like Thyroglobulin_1 PF00086.18 EMC86066.1 - 1.3e-18 66.5 1.1 5.7e-18 64.3 1.1 2.3 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat FXa_inhibition PF14670.6 EMC86066.1 - 1.4e-16 60.5 89.5 2.8e-08 33.9 7.1 6.5 5 1 1 6 6 6 5 Coagulation Factor Xa inhibitory site EGF PF00008.27 EMC86066.1 - 1.8e-11 44.1 94.5 0.00024 21.4 6.7 7.0 7 0 0 7 7 6 6 EGF-like domain EGF_MSP1_1 PF12946.7 EMC86066.1 - 2.5e-06 27.4 67.8 0.00081 19.4 1.8 5.9 6 0 0 6 6 5 4 MSP1 EGF domain 1 SGL PF08450.12 EMC86066.1 - 1.1e-05 25.2 0.1 4.4e-05 23.2 0.1 2.4 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region hEGF PF12661.7 EMC86066.1 - 0.055 14.1 74.2 0.032 14.9 5.2 7.9 6 1 0 6 6 5 0 Human growth factor-like EGF PspB PF06667.12 EMC86067.1 - 1.4 9.1 7.8 0.33 11.0 3.6 2.2 2 0 0 2 2 2 0 Phage shock protein B Death PF00531.22 EMC86068.1 - 9.7e-10 38.5 0.0 1.9e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Death domain Gal-bind_lectin PF00337.22 EMC86069.1 - 1e-75 251.7 0.0 8e-39 132.2 0.0 2.1 2 0 0 2 2 2 2 Galactoside-binding lectin WIF PF02019.18 EMC86069.1 - 0.00074 19.2 0.0 0.3 10.8 0.0 2.4 2 0 0 2 2 2 2 WIF domain DUF1080 PF06439.11 EMC86069.1 - 0.13 12.3 0.0 0.48 10.5 0.0 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1080) Spectrin PF00435.21 EMC86070.1 - 1.9e-71 237.2 33.9 7.2e-23 81.1 8.5 4.4 4 0 0 4 4 4 4 Spectrin repeat CH PF00307.31 EMC86070.1 - 1.2e-53 179.9 0.4 7e-27 93.8 0.0 3.0 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 EMC86070.1 - 4.6e-28 97.1 0.0 2.6e-27 94.7 0.0 2.5 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_1 PF00036.32 EMC86070.1 - 7.8e-09 34.5 1.0 0.004 16.6 0.0 2.9 2 0 0 2 2 2 2 EF hand CAMSAP_CH PF11971.8 EMC86070.1 - 1.5e-08 34.4 0.0 3.2e-07 30.1 0.0 2.5 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_7 PF13499.6 EMC86070.1 - 1.2e-06 28.8 1.7 3.9e-06 27.2 0.4 2.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 EMC86070.1 - 3.1e-06 26.9 3.8 4.8e-06 26.3 0.3 3.0 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 EMC86070.1 - 0.00011 21.9 3.7 0.024 14.5 0.5 3.4 3 0 0 3 3 3 2 EF-hand domain IATP PF04568.12 EMC86070.1 - 0.034 14.6 5.1 0.28 11.7 0.5 3.3 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP EF-hand_11 PF08976.11 EMC86070.1 - 0.042 14.7 0.2 0.21 12.5 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain Nsp1_C PF05064.13 EMC86070.1 - 0.068 13.0 0.3 0.068 13.0 0.3 4.8 4 2 1 6 6 6 0 Nsp1-like C-terminal region XisI PF08869.11 EMC86070.1 - 0.25 11.7 6.6 0.075 13.4 1.2 2.7 2 0 0 2 2 2 0 XisI protein Met_synt_B12 PF02965.17 EMC86071.1 - 5.1e-115 383.6 0.0 7.7e-115 383.1 0.0 1.3 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain S-methyl_trans PF02574.16 EMC86071.1 - 4.1e-78 262.9 0.0 7.9e-78 262.0 0.0 1.5 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Pterin_bind PF00809.22 EMC86071.1 - 1e-56 192.4 0.1 4.8e-56 190.2 0.0 2.2 3 0 0 3 3 3 1 Pterin binding enzyme B12-binding_2 PF02607.17 EMC86071.1 - 3.9e-24 84.9 0.0 1e-23 83.5 0.0 1.8 1 0 0 1 1 1 1 B12 binding domain B12-binding PF02310.19 EMC86071.1 - 7.7e-18 64.7 0.1 3.1e-17 62.7 0.2 2.0 2 0 0 2 2 2 1 B12 binding domain CdhD PF03599.16 EMC86071.1 - 0.0046 15.7 0.0 0.0087 14.8 0.0 1.4 1 0 0 1 1 1 1 CO dehydrogenase/acetyl-CoA synthase delta subunit IPT PF01745.16 EMC86071.1 - 0.069 12.5 0.1 0.19 11.1 0.1 1.7 1 0 0 1 1 1 0 Isopentenyl transferase NPR1_like_C PF12313.8 EMC86071.1 - 0.082 12.4 0.1 0.17 11.4 0.1 1.4 1 0 0 1 1 1 0 NPR1/NIM1 like defence protein C terminal RYDR_ITPR PF01365.21 EMC86073.1 - 1.7e-138 458.7 6.0 4.8e-73 244.9 0.0 4.3 4 0 0 4 4 4 2 RIH domain RyR PF02026.16 EMC86073.1 - 8e-125 407.4 14.3 4.5e-33 113.3 0.0 5.4 5 0 0 5 5 5 4 RyR domain RR_TM4-6 PF06459.12 EMC86073.1 - 1.8e-95 320.0 0.7 1.8e-95 320.0 0.7 2.4 2 0 0 2 2 2 1 Ryanodine Receptor TM 4-6 SPRY PF00622.28 EMC86073.1 - 8.4e-66 219.5 1.1 1.6e-20 73.4 0.0 3.6 3 0 0 3 3 3 3 SPRY domain MIR PF02815.19 EMC86073.1 - 3.5e-57 193.3 0.0 8.8e-55 185.4 0.0 3.0 2 0 0 2 2 2 1 MIR domain Ins145_P3_rec PF08709.11 EMC86073.1 - 8.4e-48 162.4 0.0 4.2e-46 156.8 0.0 2.7 2 0 0 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor RIH_assoc PF08454.11 EMC86073.1 - 1.5e-33 114.6 2.5 9.7e-33 112.0 0.3 3.6 3 0 0 3 3 3 1 RyR and IP3R Homology associated Ion_trans PF00520.31 EMC86073.1 - 3.8e-13 49.2 5.7 3.8e-13 49.2 5.7 3.1 3 0 0 3 3 3 1 Ion transport protein EF-hand_8 PF13833.6 EMC86073.1 - 3.8e-07 29.8 0.5 2.8e-06 27.1 0.1 2.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 EMC86073.1 - 2.3e-06 27.9 3.0 3.2e-06 27.5 0.9 2.5 2 0 0 2 2 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EMC86073.1 - 4.3e-05 22.7 0.3 0.00092 18.6 0.0 2.8 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 EMC86073.1 - 0.0012 18.6 0.0 0.0069 16.2 0.0 2.3 1 0 0 1 1 1 1 EF-hand domain Connexin PF00029.19 EMC86073.1 - 0.72 9.6 3.5 0.95 9.2 1.1 2.4 2 0 0 2 2 2 0 Connexin YjfB_motility PF14070.6 EMC86073.1 - 0.88 9.8 7.6 2.9 8.1 7.6 1.9 1 0 0 1 1 1 0 Putative motility protein 7tm_1 PF00001.21 EMC86074.1 - 6.6e-79 264.9 1.5 9.3e-79 264.4 1.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC86074.1 - 4.1e-09 36.2 5.1 4.1e-09 36.2 5.1 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC86074.1 - 2.5e-07 30.6 10.0 2.5e-07 30.6 10.0 2.7 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC86074.1 - 5.7e-06 26.3 12.6 1.1e-05 25.4 2.4 2.4 3 0 0 3 3 3 2 Olfactory receptor 7TM_GPCR_Srbc PF10316.9 EMC86074.1 - 0.00065 19.3 11.8 0.00065 19.3 11.8 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc CitMHS PF03600.16 EMC86074.1 - 1.8 7.7 7.7 1.9 7.6 7.7 1.3 1 1 0 1 1 1 0 Citrate transporter NicO PF03824.16 EMC86074.1 - 1.9 7.8 9.9 2.9 7.1 0.2 3.0 3 0 0 3 3 3 0 High-affinity nickel-transport protein FH2 PF02181.23 EMC86075.1 - 6.8e-97 324.9 10.2 6.8e-97 324.9 10.2 2.2 2 0 0 2 2 2 1 Formin Homology 2 Domain DEP PF00610.21 EMC86075.1 - 0.017 15.2 0.0 0.042 13.9 0.0 1.6 1 0 0 1 1 1 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Tox-REase-2 PF15646.6 EMC86075.1 - 2.3 8.4 4.0 5.7 7.1 0.1 3.2 4 0 0 4 4 4 0 Restriction endonuclease fold toxin 2 DUF4094 PF13334.6 EMC86075.1 - 6 7.4 5.8 3.6 8.1 0.6 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) ABC_tran_CTD PF16326.5 EMC86075.1 - 8.6 6.7 12.5 0.074 13.3 0.3 3.5 3 0 0 3 3 3 0 ABC transporter C-terminal domain THOC7 PF05615.13 EMC86075.1 - 9.7 6.5 15.2 0.17 12.1 0.7 3.6 3 0 0 3 3 3 0 Tho complex subunit 7 DAN PF03045.15 EMC86076.1 - 5.2e-41 139.2 10.8 7.1e-41 138.8 10.8 1.1 1 0 0 1 1 1 1 DAN domain Sfi1_C PF10638.9 EMC86076.1 - 0.091 13.5 0.9 0.15 12.9 0.2 1.7 2 0 0 2 2 2 0 Spindle body associated protein C-terminus NTP_transf_9 PF04248.12 EMC86076.1 - 0.16 11.9 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF427) RGS_DHEX PF18148.1 EMC86077.1 - 2.6e-50 168.7 1.6 2.6e-50 168.7 1.6 2.2 2 0 0 2 2 2 1 Regulator of G-protein signalling DHEX domain RGS PF00615.19 EMC86077.1 - 1.5e-35 122.1 0.3 4.9e-35 120.4 0.0 2.0 2 0 0 2 2 2 1 Regulator of G protein signaling domain DEP PF00610.21 EMC86077.1 - 9.2e-19 67.3 0.0 6.3e-18 64.6 0.0 2.3 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) G-gamma PF00631.22 EMC86077.1 - 8.7e-16 57.7 0.1 2.8e-15 56.0 0.1 1.9 1 0 0 1 1 1 1 GGL domain RGS-like PF09128.11 EMC86077.1 - 0.035 13.8 0.7 0.083 12.6 0.0 1.9 3 0 0 3 3 3 0 Regulator of G protein signalling-like domain 7tm_1 PF00001.21 EMC86078.1 - 4.4e-34 118.0 20.2 5.8e-34 117.6 20.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC86078.1 - 0.00032 20.1 11.6 0.023 14.1 0.5 2.3 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx Herpes_UL49_5 PF05702.11 EMC86078.1 - 0.039 14.0 1.1 2.6 8.2 0.2 3.0 2 0 0 2 2 2 0 Herpesvirus UL49.5 envelope/tegument protein Pex24p PF06398.11 EMC86078.1 - 2.5 7.0 7.6 2.9e+02 0.2 7.6 2.5 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin WD40 PF00400.32 EMC86080.1 - 8.6e-08 32.7 0.2 0.14 13.1 0.0 3.3 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC86080.1 - 0.029 14.7 0.1 4.3 7.7 0.1 2.8 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 EMC86080.1 - 0.087 11.5 0.0 1.4 7.6 0.0 1.9 1 1 1 2 2 2 0 Nup133 N terminal like FGase PF05013.12 EMC86081.1 - 5.8e-06 26.7 0.0 0.011 16.0 0.0 2.9 2 1 0 2 2 2 2 N-formylglutamate amidohydrolase Mito_morph_reg PF14972.6 EMC86081.1 - 0.21 11.2 3.3 0.22 11.1 0.1 2.4 3 0 0 3 3 3 0 Mitochondrial morphogenesis regulator XPG_I PF00867.18 EMC86082.1 - 3e-24 85.2 0.9 7e-24 84.0 0.1 2.2 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 EMC86082.1 - 1.5e-22 80.0 0.0 4e-22 78.6 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 EMC86082.1 - 0.00037 20.0 0.9 0.0024 17.4 0.0 2.2 2 0 0 2 2 2 1 XPG domain containing Atg8 PF02991.16 EMC86083.1 - 2.6e-39 133.6 0.3 3e-39 133.4 0.3 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EMC86083.1 - 5.5e-06 26.7 0.1 6.8e-06 26.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 PLDc_3 PF13918.6 EMC86085.1 - 3.3e-83 277.7 1.0 5.9e-83 276.9 1.0 1.4 1 0 0 1 1 1 1 PLD-like domain PLDc_2 PF13091.6 EMC86085.1 - 2e-12 47.1 0.1 9.4e-07 28.8 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EMC86085.1 - 1.6e-08 34.4 1.2 0.00014 21.9 0.0 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif FAM83 PF07894.12 EMC86085.1 - 0.053 13.1 0.0 0.093 12.3 0.0 1.3 1 0 0 1 1 1 0 FAM83 A-H CEP170_C PF15308.6 EMC86087.1 - 2e-263 876.0 62.2 2e-263 876.0 62.2 3.5 4 0 0 4 4 4 1 CEP170 C-terminus FHA PF00498.26 EMC86087.1 - 3.1e-15 56.3 0.0 1.4e-14 54.2 0.0 2.3 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EMC86087.1 - 4.3e-09 36.6 1.8 7.1e-09 35.9 0.0 2.4 3 0 0 3 3 3 1 Inner membrane component of T3SS, cytoplasmic domain DUF4254 PF14063.6 EMC86087.1 - 0.0041 16.9 1.3 0.019 14.8 0.5 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF4254) Trns_repr_metal PF02583.17 EMC86087.1 - 0.19 12.1 1.2 1.4 9.3 0.0 2.7 2 0 0 2 2 2 0 Metal-sensitive transcriptional repressor CCCAP PF15964.5 EMC86088.1 - 7.4e-299 993.1 96.1 8.3e-299 992.9 96.1 1.0 1 0 0 1 1 1 1 Centrosomal colon cancer autoantigen protein family ERM PF00769.19 EMC86088.1 - 0.0071 16.2 0.8 0.0071 16.2 0.8 4.8 3 1 1 4 4 4 1 Ezrin/radixin/moesin family CENP-F_leu_zip PF10473.9 EMC86088.1 - 0.0096 15.9 9.3 0.0096 15.9 9.3 8.3 4 1 5 9 9 9 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Pkinase PF00069.25 EMC86089.1 - 2.9e-77 259.6 0.1 6.4e-77 258.5 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC86089.1 - 2.3e-36 125.4 0.0 3.3e-36 124.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 EMC86089.1 - 9.4e-11 42.2 0.2 2.7e-10 40.7 0.0 1.9 2 0 0 2 2 2 1 PH domain Pkinase_C PF00433.24 EMC86089.1 - 1.3e-09 38.6 2.7 2.8e-09 37.5 2.7 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 EMC86089.1 - 1.3e-08 34.5 0.0 3.5e-08 33.1 0.0 1.7 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 EMC86089.1 - 0.0092 15.6 0.4 0.97 9.0 0.1 2.3 1 1 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EMC86089.1 - 0.19 11.6 0.4 0.37 10.7 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family BTB PF00651.31 EMC86090.1 - 2.2e-27 95.5 1.3 3.8e-27 94.7 1.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.6 EMC86090.1 - 1.8e-15 56.3 29.8 0.00031 21.3 3.1 5.1 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC86090.1 - 7.5e-15 54.6 26.8 1.1e-07 31.9 1.9 5.7 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.26 EMC86090.1 - 1.3e-13 50.6 34.7 0.00079 19.8 2.4 5.0 5 0 0 5 5 4 4 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EMC86090.1 - 3.6e-05 23.9 15.6 0.0037 17.5 0.0 4.7 4 1 1 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMC86090.1 - 0.0011 18.9 22.3 0.35 10.9 2.0 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.7 EMC86090.1 - 0.0027 18.0 0.1 0.0027 18.0 0.1 5.3 6 0 0 6 6 6 2 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 EMC86090.1 - 0.012 15.3 19.9 0.28 11.0 0.4 4.6 5 0 0 5 5 5 0 zinc-finger C2H2-type Zn-C2H2_12 PF18112.1 EMC86090.1 - 0.018 15.5 2.0 0.018 15.5 2.0 3.2 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain GAGA PF09237.11 EMC86090.1 - 0.022 14.5 6.3 0.54 10.1 0.2 3.5 2 1 1 3 3 3 0 GAGA factor CpXC PF14353.6 EMC86090.1 - 0.024 14.7 6.1 0.37 10.9 0.5 2.7 2 0 0 2 2 2 0 CpXC protein zf_C2H2_10 PF18414.1 EMC86090.1 - 0.1 12.2 1.4 0.34 10.5 1.4 1.9 1 0 0 1 1 1 0 C2H2 type zinc-finger zf_UBZ PF18439.1 EMC86090.1 - 0.16 11.5 7.0 3.6 7.2 0.2 3.7 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-LYAR PF08790.11 EMC86090.1 - 0.3 11.0 9.6 0.63 10.0 0.4 4.2 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger Zn-ribbon_8 PF09723.10 EMC86090.1 - 0.31 11.2 7.3 0.36 11.0 0.9 3.3 2 1 1 3 3 3 0 Zinc ribbon domain PknG_rubred PF16919.5 EMC86090.1 - 2.2 8.5 5.7 0.46 10.7 0.6 2.5 2 1 2 4 4 4 0 Protein kinase G rubredoxin domain zinc_ribbon_15 PF17032.5 EMC86090.1 - 3 8.7 9.8 1.4e+02 3.3 6.4 3.5 2 1 1 3 3 3 0 zinc-ribbon family FYVE PF01363.21 EMC86090.1 - 6.2 7.0 20.1 12 6.1 5.1 4.5 3 1 2 5 5 5 0 FYVE zinc finger XPA_N PF01286.18 EMC86090.1 - 8.1 6.6 9.4 26 4.9 0.1 4.1 4 0 0 4 4 4 0 XPA protein N-terminal DUF5530 PF17670.1 EMC86091.1 - 6.7e-25 87.5 0.0 8e-25 87.3 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5530) Adenylsucc_synt PF00709.21 EMC86092.1 - 2.3e-160 534.1 0.0 2.8e-160 533.8 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase Spore_YpjB PF09577.10 EMC86092.1 - 0.031 14.1 0.0 0.05 13.4 0.0 1.2 1 0 0 1 1 1 0 Sporulation protein YpjB (SpoYpjB) Peptidase_C97 PF05903.14 EMC86093.1 - 5.3e-39 133.5 0.0 6.9e-39 133.1 0.0 1.1 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.13 EMC86093.1 - 0.097 13.0 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 Lecithin retinol acyltransferase DUF3767 PF12597.8 EMC86094.1 - 9.6e-14 51.0 0.1 1.2e-13 50.8 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3767) AAA_33 PF13671.6 EMC86095.1 - 7.6e-28 97.5 0.3 1.5e-27 96.5 0.1 1.5 2 0 0 2 2 2 1 AAA domain SPRY PF00622.28 EMC86095.1 - 2.1e-14 53.7 0.2 2.1e-14 53.7 0.2 2.0 2 0 0 2 2 2 1 SPRY domain SRP54 PF00448.22 EMC86095.1 - 0.022 14.4 0.2 0.038 13.6 0.2 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 EMC86095.1 - 0.11 11.7 0.2 0.28 10.4 0.2 1.6 1 1 0 1 1 1 0 Zeta toxin AAA_18 PF13238.6 EMC86095.1 - 0.12 12.9 0.0 0.35 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain EF-hand_7 PF13499.6 EMC86096.1 - 4.6e-13 49.4 0.0 1.8e-07 31.5 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EMC86096.1 - 4.2e-12 45.0 0.1 0.00016 21.3 0.0 3.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_9 PF14658.6 EMC86096.1 - 5.4e-08 33.0 0.0 0.005 17.1 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EMC86096.1 - 1.2e-07 30.7 1.0 0.0086 15.6 0.0 3.4 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 EMC86096.1 - 3.2e-05 23.7 0.1 0.0063 16.3 0.0 2.7 1 1 1 2 2 2 2 EF-hand domain pair EFhand_Ca_insen PF08726.10 EMC86096.1 - 0.00059 19.9 0.1 0.0012 18.9 0.1 1.5 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_5 PF13202.6 EMC86096.1 - 0.0058 16.1 0.0 0.047 13.2 0.0 2.3 2 0 0 2 2 2 1 EF hand zf-MYND PF01753.18 EMC86098.1 - 5.8e-05 23.1 3.7 5.8e-05 23.1 3.7 2.3 2 0 0 2 2 2 1 MYND finger Consortin_C PF15281.6 EMC86099.1 - 5e-55 184.4 0.1 1.4e-54 183.0 0.1 1.8 1 0 0 1 1 1 1 Consortin C-terminus TPR_7 PF13176.6 EMC86099.1 - 0.041 13.9 0.2 0.53 10.4 0.2 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat Sacchrp_dh_NADP PF03435.18 EMC86100.1 - 1.3e-06 28.7 0.0 2e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain ELYS PF13934.6 EMC86101.1 - 9.9e-13 48.6 0.3 2e-12 47.6 0.3 1.5 1 0 0 1 1 1 1 Nuclear pore complex assembly CREPT PF16566.5 EMC86102.1 - 4.6e-16 59.3 0.1 8.6e-16 58.4 0.1 1.5 2 0 0 2 2 2 1 Cell-cycle alteration and expression-elevated protein in tumour Snapin_Pallidin PF14712.6 EMC86102.1 - 0.11 12.9 0.3 0.21 12.0 0.1 1.5 2 0 0 2 2 2 0 Snapin/Pallidin DUF4674 PF15719.5 EMC86103.1 - 1.1e-70 237.5 18.3 1.2e-70 237.4 18.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4674) TPALS PF18178.1 EMC86103.1 - 0.063 12.7 0.0 0.089 12.2 0.0 1.2 1 0 0 1 1 1 0 TIR- and PNP-associating SLOG family Glyco_hydro_46 PF01374.18 EMC86103.1 - 0.16 11.6 0.4 0.27 10.8 0.1 1.5 2 0 0 2 2 2 0 Glycosyl hydrolase family 46 Rpr2 PF04032.16 EMC86103.1 - 0.32 11.3 5.6 0.13 12.5 1.6 2.3 2 1 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Glycos_transf_2 PF00535.26 EMC86104.1 - 3e-38 131.3 0.0 4.7e-38 130.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 EMC86104.1 - 8.8e-27 93.9 2.1 1.6e-26 93.1 2.1 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 EMC86104.1 - 2.9e-08 33.9 0.0 5.1e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 EMC86104.1 - 1.3e-05 24.8 0.1 2.7e-05 23.7 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 EMC86104.1 - 0.0006 19.4 0.0 0.0018 17.8 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.6 EMC86104.1 - 0.0024 18.6 0.2 1.5 9.6 0.1 2.7 3 0 0 3 3 3 2 Ricin-type beta-trefoil lectin domain-like YL1_C PF08265.11 EMC86105.1 - 1.5e-08 34.2 2.1 5.6e-06 26.0 0.1 3.0 3 0 0 3 3 3 2 YL1 nuclear protein C-terminal domain Pentapeptide_4 PF13599.6 EMC86107.1 - 0.046 13.9 13.2 1.3e+02 2.8 0.1 5.4 2 1 1 3 3 3 0 Pentapeptide repeats (9 copies) BKACE PF05853.12 EMC86107.1 - 0.41 9.9 8.0 6.2 6.0 0.8 2.7 1 1 1 2 2 2 0 beta-keto acid cleavage enzyme SMC_hinge PF06470.13 EMC86108.1 - 1.8e-16 60.5 0.1 1.2e-15 57.8 0.0 2.4 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain SlyX PF04102.12 EMC86108.1 - 0.0083 16.7 3.9 0.0083 16.7 3.9 7.6 5 3 2 7 7 7 3 SlyX Complex1_LYR PF05347.15 EMC86109.1 - 8.9e-12 44.9 1.7 9.6e-12 44.8 1.7 1.0 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EMC86109.1 - 1.6e-05 25.5 0.7 1.7e-05 25.5 0.7 1.0 1 0 0 1 1 1 1 Complex1_LYR-like Ribonuc_P_40 PF08584.11 EMC86111.1 - 2.5e-94 315.8 0.1 2.9e-94 315.5 0.1 1.0 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit ECH_1 PF00378.20 EMC86112.1 - 1.4e-32 113.0 0.0 2.4e-32 112.3 0.0 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Chromo PF00385.24 EMC86112.1 - 2.9e-18 65.5 3.8 7.5e-18 64.2 3.8 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain ECH_2 PF16113.5 EMC86112.1 - 1.3e-16 61.0 1.2 9.5e-16 58.2 0.0 2.1 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase Mtf2_C PF14061.6 EMC86112.1 - 0.012 15.8 0.2 0.023 14.9 0.2 1.4 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 Tudor-knot PF11717.8 EMC86112.1 - 0.37 10.7 3.5 0.28 11.1 0.8 2.2 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain ECH_1 PF00378.20 EMC86113.1 - 4e-41 141.0 0.0 5.8e-41 140.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ACBP PF00887.19 EMC86113.1 - 2e-29 101.6 0.3 3.7e-29 100.8 0.3 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein ECH_2 PF16113.5 EMC86113.1 - 9.3e-19 68.1 0.0 3.1e-18 66.4 0.0 1.7 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase TPR_21 PF09976.9 EMC86113.1 - 0.075 12.7 1.5 2.3 7.9 0.2 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain Pkinase PF00069.25 EMC86114.1 - 6.5e-49 166.7 0.7 6.5e-49 166.7 0.7 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC86114.1 - 9.6e-23 80.8 0.1 3e-22 79.1 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 EMC86114.1 - 0.0012 18.0 0.3 0.002 17.2 0.3 1.4 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase zf-H2C2_2 PF13465.6 EMC86115.1 - 0.013 15.9 0.3 0.013 15.9 0.3 1.9 2 1 0 2 2 2 0 Zinc-finger double domain zf-H2C2_5 PF13909.6 EMC86115.1 - 0.039 13.7 0.0 0.039 13.7 0.0 1.8 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Adeno_IVa2 PF02456.15 EMC86115.1 - 0.081 11.7 0.0 0.088 11.6 0.0 1.0 1 0 0 1 1 1 0 Adenovirus IVa2 protein Sugar_tr PF00083.24 EMC86117.1 - 3.2e-19 69.1 17.9 4.3e-19 68.7 17.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMC86117.1 - 2.6e-14 52.9 22.2 7.1e-12 44.9 25.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PAC4 PF16093.5 EMC86118.1 - 0.0091 16.2 0.1 0.015 15.4 0.1 1.4 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 Tubulin PF00091.25 EMC86119.1 - 2.1e-69 233.7 0.0 3.3e-69 233.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EMC86119.1 - 9.4e-44 148.6 0.1 1.5e-43 148.0 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EMC86119.1 - 1.1e-05 25.7 0.0 2.7e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EMC86119.1 - 0.018 14.7 0.0 0.035 13.8 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.6 EMC86119.1 - 0.019 14.2 0.0 0.039 13.2 0.0 1.5 1 0 0 1 1 1 0 Tubulin like Abhydrolase_1 PF00561.20 EMC86120.1 - 2.9e-22 79.6 0.0 3.5e-16 59.6 0.0 2.0 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMC86120.1 - 1.6e-13 50.5 0.0 2.5e-08 33.5 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EMC86120.1 - 1.2e-09 39.1 0.0 1.8e-09 38.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 EMC86120.1 - 0.00096 18.8 0.0 0.064 12.8 0.0 2.1 2 0 0 2 2 2 1 Dienelactone hydrolase family FSH1 PF03959.13 EMC86120.1 - 0.0024 17.6 0.1 0.015 15.0 0.0 2.3 2 1 0 2 2 2 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 EMC86120.1 - 0.0048 16.4 0.0 0.057 12.9 0.0 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family BAAT_C PF08840.11 EMC86120.1 - 0.0062 16.5 0.0 0.0094 15.9 0.0 1.2 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_2 PF02230.16 EMC86120.1 - 0.027 14.3 0.0 2.7 7.8 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Esterase PF00756.20 EMC86120.1 - 0.058 13.0 0.1 0.24 11.0 0.0 1.9 1 1 0 2 2 2 0 Putative esterase Pkinase PF00069.25 EMC86121.1 - 5e-51 173.6 0.1 7.9e-51 172.9 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC86121.1 - 8.8e-51 172.7 0.1 1.3e-50 172.1 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Death PF00531.22 EMC86121.1 - 5.6e-21 74.5 0.5 3.7e-20 71.9 0.2 2.4 2 0 0 2 2 2 1 Death domain RHIM PF12721.7 EMC86121.1 - 1.5e-08 35.0 0.4 5e-08 33.3 0.4 2.0 1 0 0 1 1 1 1 RIP homotypic interaction motif RIO1 PF01163.22 EMC86121.1 - 0.0051 16.4 0.1 0.0096 15.5 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 EMC86121.1 - 0.0091 15.3 0.0 0.021 14.1 0.0 1.6 1 1 0 1 1 1 1 Kinase-like RecG_wedge PF17191.4 EMC86121.1 - 0.1 12.2 0.1 2.1 7.9 0.0 2.6 3 0 0 3 3 3 0 RecG wedge domain APH PF01636.23 EMC86121.1 - 0.15 12.0 0.1 1.2 9.0 0.0 2.3 2 1 0 2 2 2 0 Phosphotransferase enzyme family Flavodoxin_2 PF02525.17 EMC86122.1 - 6.2e-51 172.9 0.0 7.2e-51 172.7 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 EMC86122.1 - 1.5e-11 44.3 0.0 2.7e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_4 PF12682.7 EMC86122.1 - 0.005 16.6 0.0 0.0071 16.1 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin IRF-3 PF10401.9 EMC86123.1 - 3.4e-65 219.2 0.1 4.4e-65 218.8 0.1 1.1 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IRF PF00605.17 EMC86123.1 - 1.9e-42 143.8 0.2 2.9e-42 143.2 0.2 1.3 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor MH2 PF03166.14 EMC86123.1 - 0.005 17.1 0.0 0.0076 16.5 0.0 1.2 1 0 0 1 1 1 1 MH2 domain Sec5 PF15469.6 EMC86124.1 - 5.4e-55 186.2 0.8 1.7e-54 184.5 0.1 2.3 2 0 0 2 2 2 1 Exocyst complex component Sec5 TIG PF01833.24 EMC86124.1 - 1.7e-08 34.4 0.6 3.4e-08 33.4 0.6 1.5 1 0 0 1 1 1 1 IPT/TIG domain SAM_2 PF07647.17 EMC86124.1 - 0.013 15.6 0.1 0.067 13.3 0.1 2.2 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) GDP_Man_Dehyd PF16363.5 EMC86126.1 - 7.2e-112 374.0 0.0 8e-112 373.9 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EMC86126.1 - 7.4e-64 215.5 0.0 8.2e-64 215.4 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EMC86126.1 - 0.00017 20.8 0.0 0.00019 20.7 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Pkinase PF00069.25 EMC86128.1 - 2.9e-72 243.2 0.1 3.4e-72 243.0 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC86128.1 - 2.8e-39 134.9 0.0 3.4e-39 134.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMC86128.1 - 3.8e-06 26.4 0.2 5.8e-06 25.8 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EMC86128.1 - 0.00038 19.9 0.0 0.00054 19.4 0.0 1.3 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMC86128.1 - 0.0038 16.0 0.0 0.0056 15.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase MgsA_C PF12002.8 EMC86129.1 - 2.3e-59 200.1 0.0 7.7e-59 198.4 0.0 1.8 2 0 0 2 2 2 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 EMC86129.1 - 1.5e-25 89.4 0.0 3.7e-25 88.1 0.0 1.7 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 EMC86129.1 - 2.8e-09 37.5 0.4 5.2e-09 36.6 0.4 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EMC86129.1 - 5.4e-05 23.0 0.2 0.00014 21.6 0.2 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 EMC86129.1 - 0.0046 16.7 0.0 0.013 15.2 0.0 1.8 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_14 PF13173.6 EMC86129.1 - 0.019 15.0 0.0 0.037 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain DNA_pol3_delta2 PF13177.6 EMC86129.1 - 0.07 12.9 0.2 0.14 11.9 0.2 1.5 1 0 0 1 1 1 0 DNA polymerase III, delta subunit ResIII PF04851.15 EMC86129.1 - 0.098 12.7 0.1 0.16 11.9 0.1 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Serpin PF00079.20 EMC86130.1 - 1.3e-45 156.3 0.0 1.5e-45 156.1 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Acetyltransf_13 PF13880.6 EMC86131.1 - 7.1e-30 102.8 0.0 1.6e-29 101.7 0.0 1.6 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 EMC86131.1 - 2e-15 56.3 0.0 5.4e-15 54.9 0.0 1.8 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Abhydrolase_1 PF00561.20 EMC86132.1 - 3.8e-11 43.1 0.0 8.9e-10 38.6 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMC86132.1 - 2.4e-08 33.6 0.0 4.3e-08 32.7 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EMC86132.1 - 1.1e-05 26.1 0.0 1.6e-05 25.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ank_2 PF12796.7 EMC86133.1 - 4.1e-48 161.9 10.6 8.1e-16 58.4 0.1 5.0 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC86133.1 - 7.1e-47 156.9 13.2 3.1e-13 49.7 0.0 7.2 3 2 4 7 7 7 7 Ankyrin repeats (many copies) MIB_HERC2 PF06701.13 EMC86133.1 - 8.1e-47 157.3 22.0 1.5e-28 98.8 4.8 4.9 5 0 0 5 5 5 2 Mib_herc2 Ank_4 PF13637.6 EMC86133.1 - 3.7e-45 151.7 19.8 3.8e-11 43.3 0.1 7.7 2 1 7 9 9 9 8 Ankyrin repeats (many copies) SH3_15 PF18346.1 EMC86133.1 - 3.4e-42 142.6 12.4 1.6e-21 76.4 0.0 4.0 5 0 0 5 5 5 2 Mind bomb SH3 repeat domain Ank PF00023.30 EMC86133.1 - 9.1e-41 136.6 11.7 4.3e-08 33.3 0.9 9.2 8 1 0 8 8 8 8 Ankyrin repeat Ank_3 PF13606.6 EMC86133.1 - 3.2e-29 97.7 15.4 0.00063 20.0 0.3 10.5 11 0 0 11 11 10 6 Ankyrin repeat zf-C3HC4_3 PF13920.6 EMC86133.1 - 4.1e-27 93.8 59.8 1.9e-10 40.4 7.9 4.7 4 1 0 4 4 4 3 Zinc finger, C3HC4 type (RING finger) ZZ PF00569.17 EMC86133.1 - 2.7e-11 43.1 8.4 2.7e-11 43.1 8.4 3.6 3 0 0 3 3 2 1 Zinc finger, ZZ type zf-C3HC4_2 PF13923.6 EMC86133.1 - 2.9e-08 33.4 9.8 2.9e-08 33.4 9.8 4.6 4 1 1 5 5 5 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC86133.1 - 0.0011 18.8 56.1 0.01 15.7 8.3 5.0 4 1 1 5 5 4 3 Prokaryotic RING finger family 4 GATA PF00320.27 EMC86134.1 - 1.2e-30 104.8 15.7 1.7e-15 56.3 4.4 2.7 2 0 0 2 2 2 2 GATA zinc finger GATA-N PF05349.12 EMC86134.1 - 3.1e-09 37.4 0.2 3.1e-09 37.4 0.2 2.4 2 0 0 2 2 2 1 GATA-type transcription activator, N-terminal TF_Zn_Ribbon PF08271.12 EMC86134.1 - 1e-07 31.3 5.6 0.001 18.5 0.4 2.3 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 EMC86134.1 - 0.032 14.3 4.8 1.4 9.1 0.3 3.1 2 1 2 4 4 4 0 Zinc ribbon domain eIF-5_eIF-2B PF01873.17 EMC86134.1 - 0.13 12.2 4.7 5.2 7.0 0.2 2.3 2 0 0 2 2 2 0 Domain found in IF2B/IF5 Auto_anti-p27 PF06677.12 EMC86134.1 - 0.18 12.0 5.3 0.92 9.7 0.4 2.5 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DZR PF12773.7 EMC86134.1 - 0.21 11.6 7.3 5.1 7.2 0.3 3.0 1 1 2 3 3 3 0 Double zinc ribbon zf-CHY PF05495.12 EMC86134.1 - 0.21 12.1 2.5 16 6.1 0.1 2.5 2 0 0 2 2 2 0 CHY zinc finger Elf1 PF05129.13 EMC86134.1 - 0.55 10.3 5.1 9 6.4 0.0 2.8 2 1 1 3 3 3 0 Transcription elongation factor Elf1 like Cytochrom_c3_2 PF14537.6 EMC86134.1 - 0.64 10.5 4.4 0.43 11.1 1.2 2.2 2 1 0 2 2 2 0 Cytochrome c3 Cytochrome_C7 PF14522.6 EMC86134.1 - 0.77 9.8 3.8 0.6 10.2 0.9 2.2 1 1 1 2 2 2 0 Cytochrome c7 and related cytochrome c OrfB_Zn_ribbon PF07282.11 EMC86134.1 - 0.97 9.4 13.0 0.18 11.7 0.4 3.2 3 1 0 3 3 3 0 Putative transposase DNA-binding domain Prim_Zn_Ribbon PF08273.12 EMC86134.1 - 1.5 9.2 7.1 0.77 10.1 0.9 2.5 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase DUF2387 PF09526.10 EMC86134.1 - 1.5 9.0 4.2 17 5.6 0.2 3.0 1 1 2 3 3 3 0 Probable metal-binding protein (DUF2387) Cyclin_N PF00134.23 EMC86135.1 - 5e-08 32.7 0.2 7e-08 32.3 0.2 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain TPT PF03151.16 EMC86136.1 - 1.3e-05 24.7 1.4 1.8e-05 24.3 1.4 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EMC86136.1 - 0.66 10.2 16.7 0.71 10.0 6.4 2.3 2 0 0 2 2 2 0 EamA-like transporter family Mic1 PF07035.12 EMC86137.1 - 1.6e-71 239.1 2.3 2.2e-71 238.7 0.8 1.9 2 0 0 2 2 2 1 Colon cancer-associated protein Mic1-like Patched PF02460.18 EMC86138.1 - 1.4e-84 284.7 26.3 3.1e-83 280.3 26.6 2.5 2 1 0 2 2 2 1 Patched family NPC1_N PF16414.5 EMC86138.1 - 2.8e-80 269.4 6.6 2.8e-80 269.4 6.6 1.8 2 0 0 2 2 2 1 Niemann-Pick C1 N terminus Sterol-sensing PF12349.8 EMC86138.1 - 4e-57 192.4 7.1 4e-57 192.4 7.1 2.7 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.19 EMC86138.1 - 0.00017 19.4 7.1 0.00017 19.4 7.1 2.2 2 1 0 2 2 2 1 AcrB/AcrD/AcrF family MMPL PF03176.15 EMC86138.1 - 0.00034 19.7 4.9 0.00034 19.7 4.9 2.4 2 0 0 2 2 2 1 MMPL family DUF3034 PF11231.8 EMC86138.1 - 0.13 11.8 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3034) Ank_2 PF12796.7 EMC86140.1 - 3.3e-104 341.6 23.4 3.2e-14 53.3 0.0 9.8 2 2 6 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC86140.1 - 7.5e-100 326.1 20.8 8e-11 42.2 0.0 14.4 3 3 13 16 16 16 14 Ankyrin repeats (many copies) Ank PF00023.30 EMC86140.1 - 1.7e-78 255.9 43.2 6.6e-06 26.3 0.1 19.3 19 0 0 19 19 19 16 Ankyrin repeat Ank_5 PF13857.6 EMC86140.1 - 1.3e-73 242.1 36.6 1.3e-09 38.1 0.1 12.3 4 3 10 14 14 14 14 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC86140.1 - 1.9e-66 212.1 16.1 0.00021 21.5 0.0 18.7 19 0 0 19 19 19 13 Ankyrin repeat AAA_16 PF13191.6 EMC86140.1 - 0.0015 19.0 0.2 0.041 14.3 0.0 3.2 3 0 0 3 3 3 1 AAA ATPase domain NACHT PF05729.12 EMC86140.1 - 0.0039 17.1 0.3 0.028 14.3 0.3 2.4 1 1 0 1 1 1 1 NACHT domain Cadherin PF00028.17 EMC86141.1 - 0 2060.7 52.5 4.5e-25 87.9 0.4 34.6 34 1 0 34 34 34 34 Cadherin domain Cadherin_2 PF08266.12 EMC86141.1 - 5.9e-50 167.0 0.0 0.053 13.4 0.0 25.0 29 1 0 29 29 29 12 Cadherin-like Laminin_G_2 PF02210.24 EMC86141.1 - 9.4e-41 139.3 0.4 3.1e-19 69.8 0.0 3.5 3 0 0 3 3 3 2 Laminin G domain Cadherin_3 PF16184.5 EMC86141.1 - 3.3e-33 114.0 64.3 0.32 11.0 0.1 26.9 30 1 1 31 31 31 12 Cadherin-like Laminin_G_1 PF00054.23 EMC86141.1 - 1.7e-32 112.3 0.0 2.3e-17 63.5 0.0 3.2 2 0 0 2 2 2 2 Laminin G domain EGF PF00008.27 EMC86141.1 - 5.8e-22 77.6 105.1 1.2e-06 28.7 8.0 7.8 8 1 0 8 8 8 6 EGF-like domain EGF_CA PF07645.15 EMC86141.1 - 5.2e-10 39.4 25.7 5e-07 29.8 6.7 7.5 5 2 2 7 7 7 2 Calcium-binding EGF domain EGF_2 PF07974.13 EMC86141.1 - 8.8e-08 32.4 88.2 0.25 11.8 8.3 7.1 6 1 0 6 6 6 5 EGF-like domain hEGF PF12661.7 EMC86141.1 - 2.6e-07 31.0 98.2 0.00029 21.3 7.6 9.7 10 0 0 10 10 10 6 Human growth factor-like EGF HSP70 PF00012.20 EMC86142.1 - 2.3e-175 584.2 6.4 9e-166 552.6 0.0 2.8 2 1 1 3 3 3 2 Hsp70 protein MreB_Mbl PF06723.13 EMC86142.1 - 3.1e-08 32.8 0.0 7.2e-08 31.6 0.0 1.5 2 0 0 2 2 2 1 MreB/Mbl protein Pkinase PF00069.25 EMC86143.1 - 1.5e-73 247.4 0.1 2.4e-73 246.8 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC86143.1 - 2.2e-46 158.3 0.0 3.8e-46 157.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Plk4_PB1 PF18190.1 EMC86143.1 - 1.7e-41 140.7 0.0 5.7e-41 139.1 0.0 2.0 1 0 0 1 1 1 1 Polo-like Kinase 4 Polo Box 1 Plk4_PB2 PF18409.1 EMC86143.1 - 2.3e-36 124.8 0.5 1.2e-35 122.5 0.1 2.5 3 0 0 3 3 2 1 Polo-like Kinase 4 Polo Box 2 POLO_box PF00659.18 EMC86143.1 - 3.2e-09 36.8 0.0 3.3e-08 33.6 0.0 2.7 2 0 0 2 2 2 1 POLO box duplicated region Pkinase_fungal PF17667.1 EMC86143.1 - 5.3e-07 28.8 0.1 1.1e-06 27.7 0.1 1.5 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EMC86143.1 - 2.8e-05 23.2 1.2 2.8e-05 23.2 1.2 1.8 2 0 0 2 2 2 1 Haspin like kinase domain RIO1 PF01163.22 EMC86143.1 - 0.00098 18.8 0.3 0.0029 17.2 0.3 1.7 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 EMC86143.1 - 0.0014 18.0 0.0 0.003 16.9 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC86143.1 - 0.04 13.3 0.2 0.074 12.4 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4520 PF15016.6 EMC86143.1 - 0.056 13.5 0.1 0.56 10.3 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4520) TraA PF05513.11 EMC86143.1 - 0.27 11.6 0.6 0.7 10.2 0.5 1.7 1 1 0 1 1 1 0 TraA MFS_1 PF07690.16 EMC86144.1 - 2.4e-37 128.7 30.3 1.9e-30 106.0 18.2 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMC86144.1 - 9e-10 38.0 9.7 9e-10 38.0 9.7 3.6 3 1 0 3 3 3 3 Sugar (and other) transporter Pam17 PF08566.10 EMC86144.1 - 0.62 9.9 4.7 4 7.2 0.1 3.0 3 0 0 3 3 3 0 Mitochondrial import protein Pam17 DUF2048 PF09752.9 EMC86145.1 - 4.1e-162 539.2 0.0 4.7e-162 539.0 0.0 1.0 1 0 0 1 1 1 1 Abhydrolase domain containing 18 Peptidase_S15 PF02129.18 EMC86145.1 - 0.017 14.7 0.1 0.031 13.9 0.1 1.4 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) La PF05383.17 EMC86146.1 - 9.3e-22 76.9 0.1 2.4e-21 75.6 0.1 1.7 1 0 0 1 1 1 1 La domain Vault PF01505.18 EMC86146.1 - 0.0053 16.9 0.0 0.014 15.6 0.0 1.7 1 0 0 1 1 1 1 Major Vault Protein repeat domain DUF5320 PF17253.2 EMC86146.1 - 0.072 14.2 3.1 0.33 12.0 3.1 2.2 1 0 0 1 1 1 0 Family of unknown function (DUF5320) SGP PF17228.2 EMC86146.1 - 2 9.3 6.1 5.8 7.8 6.1 1.7 1 0 0 1 1 1 0 Sulphur globule protein Cyt-b5 PF00173.28 EMC86147.1 - 0.036 14.2 0.0 0.042 14.0 0.0 1.2 1 0 0 1 1 1 0 Cytochrome b5-like Heme/Steroid binding domain zf-HC5HC2H_2 PF13832.6 EMC86148.1 - 1.1e-32 112.4 2.8 1.1e-32 112.4 2.8 2.5 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EMC86148.1 - 3.8e-28 97.6 2.1 3.8e-28 97.6 2.1 3.8 4 0 0 4 4 4 1 PHD-like zinc-binding domain PHD_2 PF13831.6 EMC86148.1 - 7.7e-13 47.8 6.4 7.7e-13 47.8 6.4 3.7 4 0 0 4 4 4 1 PHD-finger PHD PF00628.29 EMC86148.1 - 8.8e-12 44.7 23.2 2.2e-10 40.3 8.7 3.3 3 0 0 3 3 3 2 PHD-finger EPL1 PF10513.9 EMC86148.1 - 1.2e-05 25.7 0.1 1.2e-05 25.7 0.1 3.5 4 1 0 4 4 3 1 Enhancer of polycomb-like C1_1 PF00130.22 EMC86148.1 - 0.0014 18.4 2.9 0.0014 18.4 2.9 3.2 2 1 1 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 EMC86148.1 - 0.0084 16.4 18.9 0.13 12.5 4.8 3.6 3 0 0 3 3 3 2 C1 domain zf-RING-like PF08746.11 EMC86148.1 - 0.02 15.2 4.6 0.02 15.2 4.6 3.3 2 0 0 2 2 2 0 RING-like domain FidL_like PF15941.5 EMC86148.1 - 0.11 13.0 0.0 0.31 11.5 0.0 1.7 1 0 0 1 1 1 0 FidL-like putative membrane protein Prok-RING_1 PF14446.6 EMC86148.1 - 2 8.4 17.8 0.81 9.7 7.4 3.3 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-RING_2 PF13639.6 EMC86148.1 - 8.2 6.9 21.4 0.28 11.5 2.1 3.0 2 1 0 2 2 2 0 Ring finger domain GAS PF13851.6 EMC86149.1 - 0.0073 15.7 108.9 0.089 12.1 16.2 8.3 2 1 4 8 8 8 7 Growth-arrest specific micro-tubule binding Sirohm_synth_C PF14823.6 EMC86149.1 - 0.014 15.0 0.1 0.096 12.3 0.1 2.5 1 0 0 1 1 1 0 Sirohaem biosynthesis protein C-terminal CCCAP PF15964.5 EMC86149.1 - 0.18 10.0 104.8 0.016 13.5 99.4 1.8 2 0 0 2 2 2 0 Centrosomal colon cancer autoantigen protein family ComP_DUS PF16732.5 EMC86149.1 - 2.6 9.0 6.4 3.2 8.7 0.3 3.6 2 1 1 3 3 3 0 Type IV minor pilin ComP, DNA uptake sequence receptor DUF1844 PF08899.11 EMC86149.1 - 6 7.2 10.4 0.78 10.1 1.2 3.9 2 1 0 3 3 3 0 Domain of unknown function (DUF1844) HALZ PF02183.18 EMC86149.1 - 6.6 7.0 32.2 1.8 8.8 0.2 7.1 5 1 1 6 6 6 0 Homeobox associated leucine zipper CBM9_2 PF16011.5 EMC86150.1 - 0.098 12.3 0.0 16 5.2 0.0 2.2 2 0 0 2 2 2 0 Carbohydrate-binding family 9 C2 PF00168.30 EMC86152.1 - 4.7e-21 75.0 0.0 5.8e-21 74.7 0.0 1.2 1 0 0 1 1 1 1 C2 domain Cytadhesin_P30 PF07271.11 EMC86154.1 - 5.7e-06 26.1 4.3 0.0045 16.6 0.4 3.6 1 1 2 4 4 4 3 Cytadhesin P30/P32 PilJ PF13675.6 EMC86154.1 - 0.68 10.0 35.6 4.5 7.3 2.2 6.9 1 1 4 5 5 5 0 Type IV pili methyl-accepting chemotaxis transducer N-term Pea-VEAacid PF08111.11 EMC86155.1 - 8e-09 35.2 25.2 1.3e+03 0.2 0.0 21.9 27 0 0 27 27 27 0 Pea-VEAacid family CLPTM1 PF05602.12 EMC86157.1 - 9.9e-116 387.3 1.8 1.2e-115 386.9 1.8 1.0 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 EMC86157.1 - 0.00024 20.8 3.5 0.0062 16.3 0.4 2.6 2 0 0 2 2 2 2 PQ loop repeat EmrE PF13536.6 EMC86157.1 - 2.2 7.8 7.6 0.19 11.3 2.5 1.7 2 0 0 2 2 2 0 Putative multidrug resistance efflux transporter NAD_kinase PF01513.21 EMC86160.1 - 9e-10 38.2 0.0 1.2e-08 34.5 0.0 2.1 1 1 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EMC86160.1 - 0.0009 18.9 0.0 0.0019 17.8 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain TPALS PF18178.1 EMC86160.1 - 0.047 13.1 0.0 0.15 11.5 0.0 1.7 2 0 0 2 2 2 0 TIR- and PNP-associating SLOG family CE2_N PF17996.1 EMC86160.1 - 0.13 12.3 0.0 1.1 9.3 0.1 2.2 2 0 0 2 2 2 0 Carbohydrate esterase 2 N-terminal DUF4988 PF16378.5 EMC86160.1 - 0.16 11.6 0.0 0.68 9.6 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function F-box-like PF12937.7 EMC86161.1 - 2.8e-15 55.9 2.9 8.1e-15 54.5 2.9 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMC86161.1 - 9.8e-10 38.1 0.9 4.2e-09 36.1 0.9 2.2 1 0 0 1 1 1 1 F-box domain LRR_6 PF13516.6 EMC86161.1 - 1e-05 25.2 4.7 0.13 12.4 0.0 6.0 6 0 0 6 6 6 2 Leucine Rich repeat LRR_1 PF00560.33 EMC86161.1 - 0.00014 21.9 14.4 5 8.1 0.0 7.5 7 2 0 7 7 7 2 Leucine Rich Repeat LRR_4 PF12799.7 EMC86161.1 - 0.046 14.2 11.8 5.6 7.5 0.0 5.3 3 2 4 7 7 7 0 Leucine Rich repeats (2 copies) LMBR1 PF04791.16 EMC86162.1 - 5.5e-189 629.3 23.4 5.5e-189 629.3 23.4 1.3 2 0 0 2 2 2 1 LMBR1-like membrane protein DUF1980 PF09323.10 EMC86162.1 - 0.28 11.1 5.6 0.34 10.8 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) EF-hand_1 PF00036.32 EMC86163.1 - 1.8e-24 83.4 11.3 6.5e-09 34.7 0.7 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EMC86163.1 - 4.3e-23 79.2 9.6 3.4e-07 29.7 0.0 4.6 4 1 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 EMC86163.1 - 5.1e-18 65.3 10.6 1.8e-08 34.7 5.1 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EMC86163.1 - 2e-14 52.4 13.8 6.2e-05 22.3 2.5 5.0 4 1 1 5 5 5 3 EF hand EF-hand_8 PF13833.6 EMC86163.1 - 5e-13 48.7 12.1 3e-07 30.2 1.1 4.2 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.7 EMC86163.1 - 0.00013 21.9 2.2 0.086 12.8 0.1 3.0 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand YugN PF08868.10 EMC86163.1 - 0.0081 16.1 0.3 0.038 13.9 0.1 1.9 2 0 0 2 2 2 1 YugN-like family SPARC_Ca_bdg PF10591.9 EMC86163.1 - 0.045 14.1 0.1 3.6 7.9 0.0 2.7 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Phage_XkdX PF09693.10 EMC86163.1 - 0.054 13.5 0.9 3.8 7.6 0.1 2.9 3 0 0 3 3 3 0 Phage uncharacterised protein (Phage_XkdX) EF-hand_9 PF14658.6 EMC86163.1 - 1.6 9.1 5.1 3.8 7.9 0.1 3.3 2 1 1 4 4 4 0 EF-hand domain FN3_7 PF18447.1 EMC86164.1 - 4.5e-36 123.0 5.8 8.1e-36 122.2 5.8 1.4 1 0 0 1 1 1 1 Fibronectin type III domain Neur_chan_memb PF02932.16 EMC86165.1 - 0.96 9.5 3.8 1.1 9.2 3.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EpoR_lig-bind PF09067.10 EMC86166.1 - 4.5e-52 174.6 0.1 5.3e-27 94.1 0.0 2.6 2 0 0 2 2 2 2 Erythropoietin receptor, ligand binding fn3 PF00041.21 EMC86166.1 - 5e-26 90.9 14.1 2.7e-10 40.4 1.3 5.1 5 0 0 5 5 5 4 Fibronectin type III domain IL6Ra-bind PF09240.10 EMC86166.1 - 1.2e-20 73.8 1.6 2.8e-09 37.3 0.1 3.1 3 0 0 3 3 3 2 Interleukin-6 receptor alpha chain, binding Pur_ac_phosph_N PF16656.5 EMC86166.1 - 0.0015 19.1 3.4 1.3 9.6 0.6 3.1 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Bgal_small_N PF02929.17 EMC86166.1 - 0.018 14.7 0.4 2.2 7.9 0.0 2.7 2 0 0 2 2 2 0 Beta galactosidase small chain Tissue_fac PF01108.17 EMC86166.1 - 2.6 7.9 7.8 29 4.6 0.1 4.0 4 0 0 4 4 4 0 Tissue factor Aminotran_3 PF00202.21 EMC86167.1 - 2.1e-90 303.3 0.0 3e-90 302.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EMC86167.1 - 0.0042 16.3 0.0 0.12 11.5 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class I and II zf-C2H2_jaz PF12171.8 EMC86168.1 - 2.6e-10 40.3 3.0 6.8e-10 39.0 1.1 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding DnaJ PF00226.31 EMC86168.1 - 1.5e-08 34.6 0.3 7.4e-08 32.4 0.3 2.3 1 0 0 1 1 1 1 DnaJ domain zf-met PF12874.7 EMC86168.1 - 2.1e-07 31.1 2.9 1.5e-06 28.4 1.2 2.4 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EMC86168.1 - 4e-07 30.3 1.2 0.023 15.0 0.2 2.9 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EMC86168.1 - 0.00028 21.5 3.9 0.48 11.4 0.5 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC86168.1 - 0.15 12.6 7.0 0.6 10.7 1.0 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type AKAP95 PF04988.12 EMC86168.1 - 0.97 9.6 24.9 3.8 7.7 7.9 3.9 3 2 0 3 3 3 0 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_3rep PF18868.1 EMC86168.1 - 1.5 9.5 0.0 1.5 9.5 0.0 3.6 1 1 1 4 4 4 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_6 PF13912.6 EMC86168.1 - 1.9 8.6 5.5 5.4 7.1 1.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger C1q PF00386.21 EMC86169.1 - 4.3e-33 114.2 3.4 5.2e-33 114.0 3.4 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 EMC86169.1 - 1.5e-11 43.9 50.7 2.9e-10 39.8 32.4 2.0 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Baculo_LEF-3 PF05847.11 EMC86169.1 - 0.042 13.1 0.1 0.052 12.7 0.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus late expression factor 3 (LEF-3) MFS_1 PF07690.16 EMC86170.1 - 1.7e-16 60.1 16.7 6.1e-11 41.8 4.4 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EMC86170.1 - 1.5e-06 27.0 6.4 1.5e-06 27.0 6.4 3.0 3 1 0 3 3 3 2 MFS/sugar transport protein DUF2298 PF10060.9 EMC86170.1 - 0.0023 16.7 1.0 0.0023 16.7 1.0 2.2 2 0 0 2 2 2 1 Uncharacterized membrane protein (DUF2298) 7tm_1 PF00001.21 EMC86171.1 - 2.8e-49 167.8 15.4 3.8e-49 167.4 15.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Peptidase_M1 PF01433.20 EMC86173.1 - 7.7e-23 81.2 0.0 1.8e-22 80.0 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 EMC86173.1 - 2.7e-17 62.9 0.5 1e-16 61.0 0.1 2.1 2 1 0 2 2 2 1 Leukotriene A4 hydrolase, C-terminal FpoO PF10621.9 EMC86173.1 - 0.15 12.4 0.8 4.5 7.6 0.0 2.9 3 0 0 3 3 3 0 F420H2 dehydrogenase subunit FpoO Peptidase_M61 PF05299.12 EMC86173.1 - 0.2 12.1 1.3 2.3 8.7 1.3 2.5 1 1 0 1 1 1 0 M61 glycyl aminopeptidase DUF4256 PF14066.6 EMC86173.1 - 0.45 10.2 3.0 12 5.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4256) Fanconi_C PF02106.15 EMC86174.1 - 3.3e-256 851.4 22.6 3.7e-256 851.2 22.6 1.0 1 0 0 1 1 1 1 Fanconi anaemia group C protein EF-hand_2 PF09068.11 EMC86174.1 - 0.0006 20.0 1.8 1.4 9.1 0.0 3.4 3 0 0 3 3 3 2 EF hand Patched PF02460.18 EMC86175.1 - 7.2e-75 252.6 18.6 5e-43 147.3 1.0 2.1 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 EMC86175.1 - 2.4e-43 147.6 4.0 2.4e-43 147.6 4.0 2.7 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation MENTAL PF10457.9 EMC86175.1 - 6.8 6.5 6.6 37 4.1 0.2 2.5 2 0 0 2 2 2 0 Cholesterol-capturing domain SNF2_N PF00176.23 EMC86176.1 - 1.3e-53 182.0 0.1 1.9e-53 181.4 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EMC86176.1 - 1.8e-21 76.6 0.0 6.6e-20 71.5 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC86176.1 - 5.7e-11 42.7 0.1 8.9e-10 38.8 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EMC86176.1 - 3.8e-07 30.0 0.0 8.6e-07 28.9 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 EMC86176.1 - 6.6e-07 28.8 0.1 1.3e-06 27.9 0.1 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase HDA2-3 PF11496.8 EMC86176.1 - 1.3e-06 27.9 0.1 8.3e-05 21.9 0.0 2.8 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 SWI2_SNF2 PF18766.1 EMC86176.1 - 0.0013 18.5 0.0 0.0028 17.3 0.0 1.5 1 0 0 1 1 1 1 SWI2/SNF2 ATPase SMN PF06003.12 EMC86176.1 - 0.021 14.1 0.0 0.036 13.3 0.0 1.3 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) AAA_34 PF13872.6 EMC86176.1 - 0.053 12.4 0.1 5 5.9 0.0 3.1 4 0 0 4 4 4 0 P-loop containing NTP hydrolase pore-1 TPT PF03151.16 EMC86177.1 - 6.1e-20 71.7 16.2 7.3e-20 71.5 16.2 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 EMC86177.1 - 0.00022 20.6 17.8 0.00031 20.1 17.8 1.2 1 0 0 1 1 1 1 UAA transporter family CRT-like PF08627.10 EMC86177.1 - 0.00026 20.1 0.9 0.00026 20.1 0.9 2.7 1 1 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like Phage_holin_3_3 PF16083.5 EMC86177.1 - 0.019 15.1 7.1 1.4 9.1 0.1 3.0 3 0 0 3 3 3 0 LydA holin phage, holin superfamily III HABP4_PAI-RBP1 PF04774.15 EMC86178.1 - 5.8e-13 49.7 7.8 5.8e-13 49.7 7.8 2.2 2 1 0 2 2 2 1 Hyaluronan / mRNA binding family DSPn PF14671.6 EMC86179.1 - 3.2e-56 189.7 3.5 5.7e-55 185.6 2.0 2.3 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 EMC86179.1 - 1.3e-15 57.4 0.0 2.7e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EMC86179.1 - 1.2e-05 25.5 0.0 2.2e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 EMC86179.1 - 5.2e-05 22.9 0.0 0.00011 21.8 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EMC86179.1 - 0.026 14.5 0.0 0.043 13.8 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 EMC86179.1 - 0.089 12.4 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family AhpC-TSA_2 PF13911.6 EMC86180.1 - 1.9e-19 69.8 0.0 2.3e-19 69.6 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 EMC86180.1 - 0.0014 18.6 0.0 0.0018 18.2 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EMC86180.1 - 0.0047 16.6 0.0 0.0068 16.1 0.0 1.1 1 0 0 1 1 1 1 Redoxin CFC PF09443.10 EMC86182.1 - 1.1e-15 57.2 10.8 1.1e-15 57.2 10.8 2.2 2 0 0 2 2 2 1 Cripto_Frl-1_Cryptic (CFC) EGF PF00008.27 EMC86182.1 - 0.01 16.1 5.8 0.01 16.1 5.8 1.9 2 0 0 2 2 2 0 EGF-like domain EGF_2 PF07974.13 EMC86182.1 - 0.015 15.6 9.5 0.015 15.6 9.5 2.2 2 1 0 2 2 2 0 EGF-like domain LRR_8 PF13855.6 EMC86183.1 - 4.9e-27 93.5 33.5 3e-09 36.5 2.6 4.2 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EMC86183.1 - 1.7e-20 72.7 39.4 5e-08 33.1 2.7 4.8 1 1 6 7 7 7 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC86183.1 - 0.0006 20.0 18.4 4.6 8.2 0.1 6.0 7 0 0 7 7 7 3 Leucine Rich Repeat LRR_6 PF13516.6 EMC86183.1 - 0.0026 17.7 16.0 4.5 7.6 0.3 5.9 7 0 0 7 7 7 4 Leucine Rich repeat RsmF_methylt_CI PF17126.5 EMC86183.1 - 0.064 13.3 0.1 20 5.3 0.0 3.4 2 1 1 3 3 3 0 RsmF rRNA methyltransferase first C-terminal domain Yae1_N PF09811.9 EMC86184.1 - 7.1e-12 44.8 39.1 1.8e+04 -5.2 39.1 4.8 1 1 0 1 1 1 0 Essential protein Yae1, N terminal Laminin_G_2 PF02210.24 EMC86185.1 - 9.3e-63 210.5 4.8 1.5e-23 83.8 0.0 3.5 4 0 0 4 4 4 3 Laminin G domain Laminin_G_1 PF00054.23 EMC86185.1 - 1.5e-47 161.1 0.2 9.9e-17 61.4 0.0 3.3 3 0 0 3 3 3 3 Laminin G domain Laminin_G_3 PF13385.6 EMC86185.1 - 2.6e-11 43.9 0.3 0.00031 20.9 0.0 3.4 4 0 0 4 4 4 2 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.27 EMC86185.1 - 3.3e-07 30.5 34.1 0.00029 21.1 8.5 3.8 3 0 0 3 3 3 2 EGF-like domain COLFI PF01410.18 EMC86185.1 - 9.2e-05 21.9 0.2 0.0034 16.7 0.2 2.8 2 1 0 2 2 2 1 Fibrillar collagen C-terminal domain EGF_2 PF07974.13 EMC86185.1 - 0.017 15.5 10.4 0.017 15.5 10.4 3.8 3 0 0 3 3 3 0 EGF-like domain MAP17 PF15807.5 EMC86185.1 - 0.12 12.6 0.1 0.24 11.6 0.1 1.4 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 F5_F8_type_C PF00754.25 EMC86186.1 - 3.8e-29 101.4 2.1 6.2e-29 100.7 0.4 2.0 2 0 0 2 2 2 1 F5/8 type C domain Laminin_G_2 PF02210.24 EMC86186.1 - 3.4e-25 89.1 0.7 5.8e-25 88.3 0.7 1.4 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 EMC86186.1 - 3.6e-15 56.3 0.1 6.3e-15 55.5 0.1 1.3 1 0 0 1 1 1 1 Laminin G domain COS PF18568.1 EMC86188.1 - 2.5e-34 117.0 2.4 3.1e-34 116.7 0.8 2.1 3 0 0 3 3 3 1 TRIM C-terminal subgroup One Signature domain SPRY PF00622.28 EMC86188.1 - 5.7e-17 61.9 0.0 1.1e-16 61.0 0.0 1.5 1 0 0 1 1 1 1 SPRY domain PRY PF13765.6 EMC86188.1 - 7.2e-13 48.0 0.0 2.8e-12 46.0 0.0 2.1 1 0 0 1 1 1 1 SPRY-associated domain zf-B_box PF00643.24 EMC86188.1 - 3.5e-09 36.7 0.8 3.5e-09 36.7 0.8 5.1 5 1 0 5 5 3 2 B-box zinc finger fn3 PF00041.21 EMC86188.1 - 3.2e-08 33.8 0.2 6.7e-08 32.8 0.2 1.5 1 0 0 1 1 1 1 Fibronectin type III domain zf-RING_UBOX PF13445.6 EMC86188.1 - 4.1e-07 29.9 9.6 4.1e-07 29.9 9.6 4.0 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EMC86188.1 - 1.2e-06 28.3 7.5 1.2e-06 28.3 7.5 4.3 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC86188.1 - 3.6e-06 26.7 11.6 3.6e-06 26.7 11.6 4.1 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMC86188.1 - 9.4e-06 25.7 12.3 9.4e-06 25.7 12.3 5.4 5 1 1 6 6 6 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EMC86188.1 - 1.1e-05 25.2 7.1 1.1e-05 25.2 7.1 5.0 5 1 1 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC86188.1 - 7.7e-05 22.9 11.4 7.7e-05 22.9 11.4 3.8 4 0 0 4 4 3 2 Ring finger domain zf-RING_5 PF14634.6 EMC86188.1 - 0.0017 18.3 9.9 0.0017 18.3 9.9 4.5 4 1 1 5 5 4 1 zinc-RING finger domain Pur_ac_phosph_N PF16656.5 EMC86188.1 - 0.0076 16.8 0.2 0.019 15.6 0.2 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain fn3_4 PF16794.5 EMC86188.1 - 0.061 13.2 0.0 0.26 11.2 0.0 2.0 3 0 0 3 3 3 0 Fibronectin-III type domain Serine_rich PF08824.10 EMC86188.1 - 0.32 11.0 7.6 3.3 7.7 7.5 2.2 1 1 0 1 1 1 0 Serine rich protein interaction domain Baculo_PEP_C PF04513.12 EMC86188.1 - 0.37 10.8 6.2 0.099 12.7 0.7 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2370 PF10176.9 EMC86189.1 - 5.2e-08 32.8 5.9 2e-05 24.4 1.4 2.6 1 1 1 2 2 2 2 Protein of unknown function (DUF2370) Comm PF15957.5 EMC86189.1 - 0.18 12.1 0.2 0.4 11.0 0.2 1.7 1 0 0 1 1 1 0 Commissureless DUF202 PF02656.15 EMC86189.1 - 0.67 10.4 4.9 2.3 8.7 4.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF202) Sprouty PF05210.13 EMC86190.1 - 3.9e-28 97.9 36.5 6.8e-28 97.1 36.5 1.4 1 0 0 1 1 1 1 Sprouty protein (Spry) Yae1_N PF09811.9 EMC86191.1 - 1.4e-14 53.5 51.1 1.8e+04 -16.3 51.1 5.1 1 1 0 1 1 1 0 Essential protein Yae1, N terminal zf-C3HC4_3 PF13920.6 EMC86193.1 - 3.8e-10 39.4 7.3 7.4e-10 38.5 7.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC86193.1 - 2.3e-09 37.4 12.4 4.7e-09 36.4 10.8 2.1 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC86193.1 - 5.8e-09 35.7 8.6 1.1e-08 34.8 8.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC86193.1 - 9.4e-09 35.0 8.0 1.7e-08 34.2 8.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMC86193.1 - 2.5e-07 30.9 7.5 5.3e-07 29.8 7.5 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EMC86193.1 - 1.1e-05 25.2 9.3 0.00013 21.7 9.7 2.2 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EMC86193.1 - 0.00012 22.0 7.7 0.00025 20.9 7.7 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EMC86193.1 - 0.00013 21.9 6.3 0.00031 20.7 6.3 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EMC86193.1 - 0.00088 19.4 4.7 0.0022 18.1 4.7 1.7 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 EMC86193.1 - 0.0019 18.2 5.1 0.009 16.0 4.7 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger DUF1644 PF07800.12 EMC86193.1 - 0.12 12.5 4.1 2 8.5 0.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1644) Baculo_IE-1 PF05290.11 EMC86193.1 - 0.42 10.6 2.5 0.72 9.8 2.5 1.3 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_4 PF14570.6 EMC86193.1 - 0.69 9.8 12.5 0.046 13.5 3.2 2.5 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain RVT_1 PF00078.27 EMC86195.1 - 0.00078 19.0 0.0 0.0016 18.0 0.0 1.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) CSF-1 PF05337.11 EMC86196.1 - 0.00066 19.8 4.8 0.83 9.8 0.2 3.5 1 1 2 3 3 3 2 Macrophage colony stimulating factor-1 (CSF-1) DUF2368 PF10166.9 EMC86196.1 - 0.26 10.9 4.0 24 4.6 0.1 3.7 1 1 3 4 4 4 0 Uncharacterised conserved protein (DUF2368) DUF1689 PF07954.11 EMC86196.1 - 0.77 10.2 9.7 90 3.5 0.2 5.2 3 2 4 7 7 7 0 Protein of unknown function (DUF1689) DUF4904 PF16247.5 EMC86196.1 - 1.6 8.5 6.1 75 3.1 0.6 4.8 2 2 1 3 3 3 0 Domain of unknown function (DUF4904) DUF3982 PF13138.6 EMC86196.1 - 3.2 7.6 16.4 58 3.6 1.9 5.7 1 1 4 5 5 5 0 Protein of unknown function (DUF3982) Chlamy_scaf PF09675.10 EMC86196.1 - 4.3 7.7 7.5 15 6.0 0.1 3.6 1 1 2 3 3 3 0 Chlamydia-phage Chp2 scaffold (Chlamy_scaf) Cornifin PF02389.15 EMC86197.1 - 0.14 12.3 40.3 1.8 8.7 15.6 3.9 1 1 3 4 4 4 0 Cornifin (SPRR) family 7tm_4 PF13853.6 EMC86198.1 - 2.3e-22 80.1 1.7 2.5e-22 79.9 1.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC86198.1 - 0.00098 18.5 5.5 0.0017 17.7 5.5 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SPICE PF15678.5 EMC86199.1 - 1.4e-147 492.3 26.7 1.4e-146 489.0 26.7 1.9 1 1 0 1 1 1 1 Centriole duplication and mitotic chromosome congression Par3_HAL_N_term PF12053.8 EMC86199.1 - 0.17 12.1 0.7 0.51 10.6 0.7 1.8 1 0 0 1 1 1 0 N-terminal of Par3 and HAL proteins SID-1_RNA_chan PF13965.6 EMC86200.1 - 1e-287 955.6 20.2 1.1e-287 955.4 20.2 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 GWT1 PF06423.12 EMC86200.1 - 9.9 6.3 10.9 0.46 10.6 0.4 3.1 2 2 0 3 3 3 0 GWT1 HLH PF00010.26 EMC86201.1 - 1.3e-10 41.0 0.5 3.8e-10 39.6 0.5 1.9 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Dicty_REP PF05086.12 EMC86201.1 - 0.4 8.6 9.1 1.2 7.1 9.1 1.7 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Acetyltransf_1 PF00583.25 EMC86202.1 - 3.6e-14 53.0 0.0 4.4e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EMC86202.1 - 1.4e-09 38.2 0.1 2e-09 37.7 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EMC86202.1 - 6.6e-09 35.8 0.0 8.2e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EMC86202.1 - 2e-05 24.8 0.1 3e-05 24.2 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMC86202.1 - 0.00021 21.2 0.0 0.00031 20.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EMC86202.1 - 0.0012 19.0 0.0 0.002 18.2 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EMC86202.1 - 0.011 15.5 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EMC86202.1 - 0.026 15.2 0.0 0.033 14.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Nudix_hydro PF18290.1 EMC86202.1 - 0.14 12.1 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Nudix hydrolase domain ATP-synt_ab PF00006.25 EMC86203.1 - 6e-109 362.7 0.0 8.4e-109 362.2 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 EMC86203.1 - 5.9e-43 145.6 0.0 1.3e-42 144.5 0.0 1.6 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 EMC86203.1 - 3.3e-14 53.1 2.4 8.1e-14 51.9 2.4 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Zn_ribbon_SprT PF17283.2 EMC86204.1 - 0.014 15.3 5.8 0.3 11.0 0.5 3.2 3 0 0 3 3 3 0 SprT-like zinc ribbon domain Yippee-Mis18 PF03226.14 EMC86204.1 - 0.033 14.4 1.6 0.18 12.0 1.0 2.2 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly SelR PF01641.18 EMC86204.1 - 0.094 12.8 0.1 0.41 10.7 0.1 1.9 1 1 0 1 1 1 0 SelR domain DZR PF12773.7 EMC86204.1 - 0.24 11.5 5.6 11 6.1 5.6 2.6 1 1 0 1 1 1 0 Double zinc ribbon TackOD1 PF18551.1 EMC86204.1 - 2.5 7.7 6.3 8.5 6.0 0.9 2.3 2 1 0 2 2 2 0 Thaumarchaeal output domain 1 NTP_transf_7 PF07984.12 EMC86205.1 - 2.9e-156 519.6 0.7 3.4e-156 519.4 0.7 1.0 1 0 0 1 1 1 1 Nucleotidyltransferase CRAL_TRIO_2 PF13716.6 EMC86206.1 - 2e-32 112.3 2.5 3.4e-32 111.5 2.5 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Macro PF01661.21 EMC86206.1 - 1e-27 96.5 0.0 1.8e-27 95.7 0.0 1.4 1 0 0 1 1 1 1 Macro domain CRAL_TRIO PF00650.20 EMC86206.1 - 2.1e-06 27.5 1.2 5.3e-06 26.2 1.2 1.7 1 0 0 1 1 1 1 CRAL/TRIO domain Epimerase_2 PF02350.19 EMC86206.1 - 0.14 11.0 0.1 0.23 10.3 0.1 1.3 1 0 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase WD40 PF00400.32 EMC86207.1 - 4.1e-56 185.7 16.9 6.4e-09 36.3 0.1 10.6 10 0 0 10 10 10 10 WD domain, G-beta repeat Utp12 PF04003.12 EMC86207.1 - 1.9e-21 76.4 0.3 1.9e-21 76.4 0.3 1.6 2 0 0 2 2 2 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EMC86207.1 - 1.8e-19 69.8 5.7 0.00025 21.3 0.0 8.9 4 3 7 11 11 11 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EMC86207.1 - 2e-08 34.0 0.0 0.0025 17.2 0.0 4.0 3 2 0 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.5 EMC86207.1 - 7.5e-07 28.4 0.7 5.2 5.9 0.0 6.7 3 2 2 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EMC86207.1 - 0.13 10.9 2.9 10 4.6 0.0 4.3 5 0 0 5 5 5 0 Nucleoporin Nup120/160 PapD-like PF14874.6 EMC86208.1 - 3.5e-10 40.0 0.0 5.9e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Flagellar-associated PapD-like T-box PF00907.22 EMC86209.1 - 2.7e-64 216.8 0.0 3.9e-64 216.3 0.0 1.2 1 0 0 1 1 1 1 T-box T-box PF00907.22 EMC86210.1 - 2.8e-07 31.0 0.0 4.2e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 T-box tRNA-synt_1b PF00579.25 EMC86211.1 - 1.2e-68 231.6 0.0 1.6e-68 231.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Occludin_ELL PF07303.13 EMC86211.1 - 0.063 14.0 0.2 3 8.6 0.0 2.3 2 0 0 2 2 2 0 Occludin homology domain FMN_dh PF01070.18 EMC86212.1 - 2.1e-132 441.4 0.0 2.8e-132 441.0 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 EMC86212.1 - 8e-08 31.7 1.7 4.7e-07 29.1 1.1 2.1 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 EMC86212.1 - 6.1e-05 22.3 0.1 8.8e-05 21.8 0.1 1.1 1 0 0 1 1 1 1 Conserved region in glutamate synthase His_biosynth PF00977.21 EMC86212.1 - 0.00091 18.8 0.2 0.0041 16.6 0.0 1.9 1 1 1 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.14 EMC86212.1 - 0.017 14.4 0.3 0.53 9.6 0.1 2.3 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG G3P_antiterm PF04309.12 EMC86212.1 - 0.023 14.1 0.0 6.7 6.1 0.0 2.3 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator NMO PF03060.15 EMC86212.1 - 0.048 13.0 0.7 0.077 12.4 0.7 1.3 1 0 0 1 1 1 0 Nitronate monooxygenase DHO_dh PF01180.21 EMC86212.1 - 0.19 10.9 0.1 0.37 10.0 0.1 1.4 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase 3Beta_HSD PF01073.19 EMC86213.1 - 2e-94 315.7 0.0 2.4e-94 315.4 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EMC86213.1 - 1.5e-20 73.7 0.0 1.9e-20 73.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMC86213.1 - 1.3e-15 57.6 0.0 5.4e-15 55.6 0.0 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EMC86213.1 - 7.4e-15 54.8 0.0 2.5e-14 53.1 0.0 1.7 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 EMC86213.1 - 2.4e-11 43.3 0.0 3.5e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EMC86213.1 - 5.7e-10 39.4 0.0 8.6e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 EMC86213.1 - 4.6e-06 25.9 0.0 7.5e-06 25.2 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.13 EMC86213.1 - 6.1e-06 26.0 0.0 9.1e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family KR PF08659.10 EMC86213.1 - 0.0029 17.5 0.1 0.0061 16.5 0.1 1.5 1 1 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 EMC86213.1 - 0.004 17.4 0.1 0.0085 16.4 0.1 1.6 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DUF2895 PF11444.8 EMC86214.1 - 0.055 12.9 0.0 0.068 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2895) Glyco_hydro_47 PF01532.20 EMC86215.1 - 4e-157 523.8 0.0 5.3e-157 523.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 HSP9_HSP12 PF04119.12 EMC86215.1 - 0.19 12.1 2.8 0.51 10.8 2.0 2.1 2 0 0 2 2 2 0 Heat shock protein 9/12 DUF4407 PF14362.6 EMC86215.1 - 0.51 9.6 1.4 0.81 9.0 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1640 PF07798.11 EMC86215.1 - 0.63 10.1 4.8 0.51 10.4 3.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) Apolipoprotein PF01442.18 EMC86215.1 - 4.4 7.1 10.7 1.2 8.9 7.1 1.7 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Ig_3 PF13927.6 EMC86216.1 - 8.1e-07 29.6 0.3 0.011 16.3 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 EMC86216.1 - 3.3e-05 24.0 0.6 0.066 13.4 0.1 2.6 2 1 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 EMC86216.1 - 5.1e-05 23.3 0.1 9.4e-05 22.4 0.1 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain I-set PF07679.16 EMC86216.1 - 0.00049 20.1 0.1 0.0045 17.0 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin I-set domain V-set PF07686.17 EMC86216.1 - 0.0044 17.2 1.7 0.013 15.7 0.6 2.0 2 0 0 2 2 2 1 Immunoglobulin V-set domain C1-set PF07654.15 EMC86216.1 - 0.012 16.0 0.7 0.82 10.1 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin C1-set domain V-set_CD47 PF08204.11 EMC86216.1 - 0.1 12.6 0.6 0.18 11.8 0.6 1.4 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain ANF_receptor PF01094.28 EMC86217.1 - 1.2e-108 363.4 0.0 1.6e-108 363.0 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.22 EMC86217.1 - 3.9e-65 219.9 30.9 7.8e-65 218.9 30.9 1.5 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.14 EMC86217.1 - 1.5e-17 63.3 11.9 4.1e-17 61.9 11.9 1.9 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.6 EMC86217.1 - 3.1e-12 46.8 0.0 1.5e-10 41.3 0.0 2.7 2 1 0 2 2 2 1 Periplasmic binding protein Ephrin_rec_like PF07699.13 EMC86217.1 - 0.017 14.8 8.8 0.057 13.2 8.8 1.9 1 0 0 1 1 1 0 Putative ephrin-receptor like FAM199X PF15814.5 EMC86217.1 - 0.35 9.9 4.6 0.66 9.0 4.6 1.4 1 0 0 1 1 1 0 Protein family FAM199X DUF2614 PF11023.8 EMC86217.1 - 1.5 9.0 6.4 0.29 11.2 0.8 2.6 2 0 0 2 2 2 0 Zinc-ribbon containing domain Cystatin PF00031.21 EMC86218.1 - 9.9e-17 61.0 0.3 1.1e-16 60.9 0.3 1.0 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.5 EMC86218.1 - 0.033 14.5 0.0 0.036 14.4 0.0 1.3 1 0 0 1 1 1 0 Aspartic acid proteinase inhibitor Cystatin PF00031.21 EMC86219.1 - 4.1e-18 65.4 0.1 4.5e-18 65.3 0.1 1.1 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.5 EMC86219.1 - 0.012 15.9 0.1 0.017 15.5 0.1 1.2 1 0 0 1 1 1 0 Aspartic acid proteinase inhibitor Cid2 PF09774.9 EMC86220.1 - 1.2e-16 61.6 6.4 3.1e-15 57.0 6.4 2.0 1 1 0 1 1 1 1 Caffeine-induced death protein 2 DUF5344 PF17279.2 EMC86220.1 - 0.0084 16.7 0.1 0.016 15.8 0.1 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5344) Orbi_VP5 PF00901.17 EMC86220.1 - 0.055 11.9 1.0 0.061 11.7 1.0 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 FOXP-CC PF16159.5 EMC86220.1 - 0.99 10.1 6.8 11 6.7 0.4 2.4 1 1 1 2 2 2 0 FOXP coiled-coil domain DUF1075 PF06388.11 EMC86221.1 - 3.4e-48 162.7 0.1 4.2e-48 162.4 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1075) Arm PF00514.23 EMC86222.1 - 3.2e-88 287.4 17.5 1.8e-13 50.0 0.0 8.3 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 EMC86222.1 - 7.5e-27 93.6 6.6 1.5e-26 92.7 6.6 1.5 1 0 0 1 1 1 1 Importin beta binding domain Arm_3 PF16186.5 EMC86222.1 - 6e-23 80.2 3.7 7.1e-23 79.9 1.8 2.1 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_2 PF13646.6 EMC86222.1 - 2e-17 63.3 0.0 8.1e-07 29.3 0.0 4.8 2 1 3 6 6 5 3 HEAT repeats HEAT_EZ PF13513.6 EMC86222.1 - 1.3e-13 51.1 7.1 2.3e-05 24.8 0.0 5.9 4 2 1 5 5 5 3 HEAT-like repeat HEAT PF02985.22 EMC86222.1 - 2.1e-11 43.0 6.9 0.0024 18.0 0.0 7.6 9 1 0 9 9 8 3 HEAT repeat RICTOR_V PF14668.6 EMC86222.1 - 2e-05 24.8 1.5 0.29 11.4 0.0 4.8 4 1 1 5 5 5 1 Rapamycin-insensitive companion of mTOR, domain 5 V-ATPase_H_C PF11698.8 EMC86222.1 - 2.4e-05 24.4 0.3 0.092 12.9 0.1 4.0 3 3 1 4 4 4 2 V-ATPase subunit H Arm_2 PF04826.13 EMC86222.1 - 0.00015 21.3 0.4 0.34 10.3 0.2 3.2 3 1 1 4 4 4 2 Armadillo-like V-ATPase_H_N PF03224.14 EMC86222.1 - 0.0018 17.6 0.3 0.53 9.5 0.0 3.3 2 1 1 3 3 3 1 V-ATPase subunit H DUF3361 PF11841.8 EMC86222.1 - 0.019 14.9 4.2 11 5.9 0.1 3.9 4 1 1 5 5 5 0 Domain of unknown function (DUF3361) Atx10homo_assoc PF09759.9 EMC86222.1 - 0.021 14.9 0.1 0.46 10.5 0.0 2.7 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain Moulting_cycle PF04870.16 EMC86222.1 - 0.027 13.7 1.5 0.044 13.1 1.5 1.2 1 0 0 1 1 1 0 Moulting cycle HEAT_PBS PF03130.16 EMC86222.1 - 2.2 9.2 7.9 11 7.1 0.3 5.0 6 1 0 6 6 5 0 PBS lyase HEAT-like repeat V-set PF07686.17 EMC86223.1 - 1.5e-20 73.4 0.2 1.2e-14 54.4 0.0 2.9 3 0 0 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC86223.1 - 4.6e-17 62.4 3.1 1.2e-07 32.2 0.4 3.5 3 0 0 3 3 3 2 Immunoglobulin domain C1-set PF07654.15 EMC86223.1 - 1e-13 51.5 0.0 3.7e-13 49.7 0.0 2.1 1 0 0 1 1 1 1 Immunoglobulin C1-set domain I-set PF07679.16 EMC86223.1 - 2.4e-13 50.0 0.0 1.4e-05 25.0 0.0 3.6 4 1 0 4 4 4 2 Immunoglobulin I-set domain ig PF00047.25 EMC86223.1 - 6.2e-13 48.7 0.9 4.6e-06 26.7 0.1 3.2 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 EMC86223.1 - 2.5e-09 37.3 0.2 0.0042 17.4 0.1 3.2 2 1 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 EMC86223.1 - 0.019 15.0 0.6 0.13 12.3 0.1 2.5 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 EMC86223.1 - 0.15 12.1 0.0 0.61 10.2 0.0 2.1 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain V-set_CD47 PF08204.11 EMC86223.1 - 0.18 11.8 0.0 0.71 9.9 0.0 1.9 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain ASC PF00858.24 EMC86224.1 - 4.1e-107 358.9 14.4 5.2e-107 358.6 14.4 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Synaptobrevin PF00957.21 EMC86225.1 - 1.7e-33 114.3 2.6 1.9e-33 114.1 2.6 1.0 1 0 0 1 1 1 1 Synaptobrevin MCU PF04678.13 EMC86225.1 - 0.0028 17.8 0.2 0.0036 17.4 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial calcium uniporter PRIMA1 PF16101.5 EMC86225.1 - 0.013 15.5 4.5 0.14 12.2 0.3 2.1 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Duffy_binding PF05424.11 EMC86225.1 - 0.059 13.4 0.1 0.072 13.1 0.1 1.1 1 0 0 1 1 1 0 Duffy binding domain MRP-L51 PF10244.9 EMC86226.1 - 1.7e-34 117.9 0.6 2e-34 117.6 0.6 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit DUF4817 PF16087.5 EMC86226.1 - 0.07 12.9 1.3 6.6 6.6 0.1 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain (DUF4817) Gp_dh_C PF02800.20 EMC86227.1 - 4.1e-70 234.4 0.0 6.5e-70 233.8 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 EMC86227.1 - 1e-34 118.9 0.1 2.8e-34 117.5 0.1 1.8 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain OstA PF03968.14 EMC86227.1 - 0.021 15.0 0.0 0.044 14.0 0.0 1.5 1 0 0 1 1 1 0 OstA-like protein Filament PF00038.21 EMC86228.1 - 1.7e-14 54.1 25.2 3.8e-10 39.8 3.7 2.8 3 0 0 3 3 3 2 Intermediate filament protein HlyE PF06109.13 EMC86228.1 - 0.1 11.9 1.6 0.12 11.6 0.0 1.8 3 0 0 3 3 3 0 Haemolysin E (HlyE) T2SSF PF00482.23 EMC86228.1 - 0.17 11.9 0.3 0.37 10.7 0.3 1.5 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F PAPA-1 PF04795.12 EMC86228.1 - 0.27 12.1 6.6 0.3 11.9 0.1 3.2 2 1 1 3 3 3 0 PAPA-1-like conserved region Snapin_Pallidin PF14712.6 EMC86228.1 - 0.97 9.9 13.2 0.26 11.7 3.8 3.1 3 1 0 3 3 3 0 Snapin/Pallidin 7tm_1 PF00001.21 EMC86229.1 - 7.4e-48 163.2 22.3 8.7e-48 162.9 22.3 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) wnt PF00110.19 EMC86230.1 - 1e-81 275.0 1.9 1.1e-81 274.8 1.9 1.0 1 0 0 1 1 1 1 wnt family PBP_sp32 PF07222.12 EMC86231.1 - 1.9e-38 132.3 3.3 1.3e-36 126.3 0.0 3.0 3 1 0 3 3 3 2 Proacrosin binding protein sp32 Kazal_2 PF07648.15 EMC86231.1 - 0.0006 19.9 0.6 0.0006 19.9 0.6 4.0 4 1 0 4 4 4 1 Kazal-type serine protease inhibitor domain ING PF12998.7 EMC86232.1 - 1.1e-27 96.6 0.5 1.1e-27 96.6 0.5 1.9 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EMC86232.1 - 2.4e-06 27.4 7.6 4.4e-06 26.5 7.6 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EMC86232.1 - 0.0064 16.0 1.1 0.011 15.3 1.1 1.4 1 0 0 1 1 1 1 PHD-finger Spc7 PF08317.11 EMC86232.1 - 0.0066 15.4 6.7 0.0089 14.9 6.7 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein zf-HC5HC2H PF13771.6 EMC86232.1 - 0.0086 16.3 0.5 0.02 15.1 0.5 1.7 1 0 0 1 1 1 1 PHD-like zinc-binding domain AP3D1 PF06375.11 EMC86232.1 - 0.015 15.5 5.7 0.019 15.2 5.7 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 LMBR1 PF04791.16 EMC86232.1 - 0.04 12.8 1.3 0.049 12.5 1.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF1319 PF07028.11 EMC86232.1 - 0.13 12.5 0.9 0.6 10.3 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1319) SOGA PF11365.8 EMC86232.1 - 0.2 12.8 11.1 1.5 10.0 5.3 2.9 1 1 1 2 2 2 0 Protein SOGA ABC_tran_CTD PF16326.5 EMC86232.1 - 0.23 11.7 5.4 0.82 10.0 0.7 2.4 2 0 0 2 2 2 0 ABC transporter C-terminal domain ORF6C PF10552.9 EMC86232.1 - 0.35 10.9 7.4 1.1 9.3 2.2 2.1 2 0 0 2 2 2 0 ORF6C domain DASH_Spc19 PF08287.11 EMC86232.1 - 8.1 6.3 15.6 1.7 8.5 8.9 2.0 1 1 0 2 2 2 0 Spc19 zf-H2C2_2 PF13465.6 EMC86233.1 - 6.4e-36 121.2 72.7 1.3e-06 28.6 0.3 9.7 10 0 0 10 10 10 8 Zinc-finger double domain zf-C2H2 PF00096.26 EMC86233.1 - 5.9e-34 114.6 77.8 1.8e-05 24.9 3.2 9.6 9 0 0 9 9 9 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC86233.1 - 1.3e-17 62.9 75.1 0.002 18.8 3.0 9.9 10 0 0 10 10 9 7 C2H2-type zinc finger zf-C2HC_2 PF13913.6 EMC86233.1 - 6.1e-05 22.8 6.6 0.0035 17.2 0.5 6.1 7 0 0 7 7 6 2 zinc-finger of a C2HC-type zf-Di19 PF05605.12 EMC86233.1 - 0.00013 22.2 45.3 0.023 15.0 6.5 5.3 3 1 2 5 5 4 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 EMC86233.1 - 0.00057 20.1 51.1 0.0087 16.3 0.6 8.3 7 1 1 8 8 8 3 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 EMC86233.1 - 0.0043 17.5 41.0 0.36 11.3 4.0 6.3 2 1 3 6 6 5 3 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_5 PF13909.6 EMC86233.1 - 0.0063 16.2 11.2 0.012 15.4 1.7 9.8 10 1 0 10 10 9 2 C2H2-type zinc-finger domain TerY_C PF15616.6 EMC86233.1 - 0.29 11.2 14.6 0.57 10.3 0.5 3.8 2 1 2 4 4 4 0 TerY-C metal binding domain zf-AN1 PF01428.16 EMC86233.1 - 0.65 10.2 31.5 13 6.1 0.1 7.5 7 1 0 7 7 7 0 AN1-like Zinc finger zinc_ribbon_9 PF14369.6 EMC86233.1 - 0.71 10.2 17.7 11 6.4 0.1 6.0 5 1 0 5 5 5 0 zinc-ribbon zf-met PF12874.7 EMC86233.1 - 1.1 9.8 59.5 0.26 11.7 2.4 8.8 8 0 0 8 8 8 0 Zinc-finger of C2H2 type C1_1 PF00130.22 EMC86233.1 - 1.2 9.1 29.1 1.8 8.5 2.9 6.1 2 2 3 5 5 5 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn-ribbon_8 PF09723.10 EMC86233.1 - 3.4 7.9 32.7 0.1 12.7 2.4 5.7 3 2 3 6 6 6 0 Zinc ribbon domain Sprouty PF05210.13 EMC86233.1 - 7.9 6.9 22.7 2.1 8.8 3.0 3.9 4 0 0 4 4 4 0 Sprouty protein (Spry) CSN7a_helixI PF18392.1 EMC86234.1 - 2.4e-20 72.2 3.2 4.2e-20 71.4 3.2 1.4 1 0 0 1 1 1 1 COP9 signalosome complex subunit 7a helix I domain PCI PF01399.27 EMC86234.1 - 5.1e-08 33.4 0.1 6.2e-07 29.9 0.1 2.2 2 1 0 2 2 2 1 PCI domain DUF4200 PF13863.6 EMC86234.1 - 0.0092 16.4 2.1 0.026 14.9 2.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4200) Ribosomal_S3_C PF00189.20 EMC86234.1 - 0.011 16.2 0.1 0.02 15.4 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein S3, C-terminal domain Band_3_cyto PF07565.13 EMC86234.1 - 0.28 11.0 3.5 0.37 10.6 3.5 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Mlf1IP PF10248.9 EMC86235.1 - 3e-60 203.1 4.3 3.7e-60 202.8 4.3 1.1 1 0 0 1 1 1 1 Myelodysplasia-myeloid leukemia factor 1-interacting protein V-set PF07686.17 EMC86237.1 - 0.12 12.6 0.0 0.15 12.2 0.0 1.1 1 0 0 1 1 1 0 Immunoglobulin V-set domain V-set PF07686.17 EMC86238.1 - 4e-07 30.2 0.2 0.00013 22.1 0.0 2.7 3 0 0 3 3 3 1 Immunoglobulin V-set domain Ig_2 PF13895.6 EMC86238.1 - 4.4e-07 30.1 0.4 0.00043 20.6 0.1 2.1 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 EMC86238.1 - 6.5e-07 29.9 0.1 0.0023 18.5 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 EMC86238.1 - 1e-06 28.8 0.2 0.03 14.5 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC86238.1 - 4.8e-06 26.5 0.0 0.00028 20.9 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin I-set domain Izumo-Ig PF16706.5 EMC86238.1 - 0.041 13.9 0.0 3.8 7.6 0.0 2.6 2 1 0 2 2 2 0 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 EMC86238.1 - 0.082 12.5 0.0 2.2 7.9 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin domain C2-set PF05790.15 EMC86238.1 - 0.12 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin C2-set domain 7tm_1 PF00001.21 EMC86239.1 - 2.6e-16 59.7 12.8 4.6e-16 58.9 12.8 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC86239.1 - 4.5e-08 33.0 4.1 4.5e-08 33.0 4.1 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC86239.1 - 0.015 15.1 0.4 0.024 14.4 0.4 1.3 1 0 0 1 1 1 0 Olfactory receptor Ni_hydr_CYTB PF01292.20 EMC86239.1 - 0.28 10.8 8.6 4.7 6.8 7.7 2.6 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 LapA_dom PF06305.11 EMC86239.1 - 0.98 9.3 6.9 1.7 8.6 0.3 3.2 3 1 0 3 3 3 0 Lipopolysaccharide assembly protein A domain 2OG-FeII_Oxy_3 PF13640.6 EMC86240.1 - 1.2e-10 42.1 0.0 2.4e-10 41.2 0.0 1.5 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 EMC86240.1 - 1.2e-06 29.0 0.0 1.8e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 EMC86240.1 - 0.017 15.8 0.0 0.029 15.0 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily WD40 PF00400.32 EMC86241.1 - 4e-43 144.6 21.5 3e-07 31.0 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC86241.1 - 9.2e-16 57.9 0.0 0.0004 20.6 0.1 5.7 1 1 5 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC86241.1 - 1e-07 32.0 0.0 0.033 14.1 0.0 3.1 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EMC86241.1 - 9.3e-06 25.2 0.1 0.00093 18.6 0.0 3.2 1 1 1 3 3 3 1 WD40-like domain Ge1_WD40 PF16529.5 EMC86241.1 - 0.0021 17.1 1.6 16 4.3 0.1 4.2 2 1 3 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 EMC86241.1 - 0.0033 16.0 0.0 0.022 13.3 0.0 2.1 2 0 0 2 2 2 1 Cytochrome D1 heme domain TIM PF00121.18 EMC86243.1 - 4.9e-80 268.4 0.0 6e-80 268.1 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase LRR_4 PF12799.7 EMC86244.1 - 1.9e-24 85.3 25.3 1.4e-07 31.7 2.4 5.5 6 0 0 6 6 6 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC86244.1 - 2.2e-20 72.9 6.8 1.7e-17 63.5 1.9 2.6 1 1 0 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 EMC86244.1 - 1.5e-15 56.7 29.6 6.5e-08 32.2 4.4 5.6 2 1 4 6 6 6 5 Leucine rich repeat LRR_6 PF13516.6 EMC86244.1 - 7.7e-08 31.8 21.7 0.18 11.9 0.2 8.6 10 0 0 10 10 10 3 Leucine Rich repeat LRR_1 PF00560.33 EMC86244.1 - 0.00093 19.4 16.0 8.2 7.4 0.2 6.7 6 2 0 6 6 6 2 Leucine Rich Repeat LRR_3 PF07725.12 EMC86244.1 - 0.018 14.8 8.2 2.5 8.1 0.1 4.9 5 0 0 5 5 5 0 Leucine Rich Repeat Enolase_C PF00113.22 EMC86245.1 - 4e-158 525.3 0.0 5e-158 525.0 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EMC86245.1 - 1.1e-59 200.3 0.0 2e-59 199.5 0.0 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 EMC86245.1 - 2.8e-09 36.9 0.0 4.2e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 EMC86245.1 - 3.5e-05 23.1 0.3 7.7e-05 22.0 0.3 1.6 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus P_C10 PF14974.6 EMC86246.1 - 3.2e-38 129.9 0.1 3.6e-38 129.8 0.1 1.0 1 0 0 1 1 1 1 Protein C10 FAST_2 PF08368.12 EMC86246.1 - 0.013 16.3 0.0 0.034 14.9 0.0 1.6 1 1 1 2 2 2 0 FAST kinase-like protein, subdomain 2 DUF4309 PF14172.6 EMC86246.1 - 0.087 12.8 0.0 7.4 6.6 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4309) Y_phosphatase PF00102.27 EMC86247.1 - 1.9e-78 263.3 0.3 3.1e-78 262.6 0.3 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase SH2 PF00017.24 EMC86247.1 - 1.1e-45 153.6 0.1 1.7e-21 76.1 0.0 3.0 3 0 0 3 3 3 2 SH2 domain DSPc PF00782.20 EMC86247.1 - 1.9e-05 24.5 0.1 6.6e-05 22.7 0.1 2.0 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC86247.1 - 0.0014 18.7 0.0 0.0043 17.0 0.0 1.8 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EMC86247.1 - 0.0054 16.9 0.0 0.028 14.5 0.0 2.3 2 0 0 2 2 2 1 Inositol hexakisphosphate MRNIP PF15749.5 EMC86247.1 - 0.13 13.0 0.2 0.13 13.0 0.2 2.3 2 0 0 2 2 2 0 MRN-interacting protein Band_7 PF01145.25 EMC86248.1 - 3.9e-17 62.8 5.0 5.6e-17 62.3 5.0 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family Med2 PF11214.8 EMC86248.1 - 0.00034 20.7 1.9 0.00064 19.8 1.9 1.4 1 0 0 1 1 1 1 Mediator complex subunit 2 MBOAT PF03062.19 EMC86249.1 - 1.3e-62 212.2 13.1 1.3e-62 212.2 13.1 2.3 3 1 0 3 3 3 1 MBOAT, membrane-bound O-acyltransferase family Trypsin PF00089.26 EMC86250.1 - 3.3e-49 167.7 0.0 4.7e-49 167.2 0.0 1.2 1 0 0 1 1 1 1 Trypsin CUB PF00431.20 EMC86250.1 - 3.4e-44 149.7 0.2 8.5e-24 84.0 0.0 2.4 2 0 0 2 2 2 2 CUB domain Sushi PF00084.20 EMC86250.1 - 5.9e-12 46.0 3.0 7e-06 26.5 0.3 2.9 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) FXa_inhibition PF14670.6 EMC86250.1 - 1e-08 35.3 7.1 5e-08 33.1 7.1 2.3 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site Trypsin_2 PF13365.6 EMC86250.1 - 3.6e-05 24.7 0.0 6.3e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain CUB_2 PF02408.20 EMC86250.1 - 6e-05 22.8 0.6 0.49 10.2 0.1 2.6 2 0 0 2 2 2 2 CUB-like domain EGF_CA PF07645.15 EMC86250.1 - 0.00011 22.3 8.8 0.00011 22.3 8.8 3.0 3 0 0 3 3 3 1 Calcium-binding EGF domain DERM PF14704.6 EMC86250.1 - 0.063 13.8 4.1 2.7 8.4 0.6 2.7 3 0 0 3 3 3 0 Dermatopontin EGF PF00008.27 EMC86250.1 - 0.27 11.6 14.0 0.056 13.8 9.0 2.6 2 0 0 2 2 2 0 EGF-like domain HRM PF02793.22 EMC86250.1 - 3.6 8.0 10.5 1.9 8.8 0.6 3.0 3 0 0 3 3 3 0 Hormone receptor domain CUB PF00431.20 EMC86251.1 - 4.8e-52 174.9 0.1 2e-28 98.9 0.1 2.4 2 0 0 2 2 2 2 CUB domain Trypsin PF00089.26 EMC86251.1 - 3.1e-51 174.3 0.0 4.6e-51 173.7 0.0 1.3 1 0 0 1 1 1 1 Trypsin Sushi PF00084.20 EMC86251.1 - 2.1e-15 57.0 18.9 3e-10 40.5 0.9 4.2 3 1 1 4 4 4 2 Sushi repeat (SCR repeat) FXa_inhibition PF14670.6 EMC86251.1 - 5e-09 36.3 10.7 2.9e-08 33.9 7.9 2.9 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site Trypsin_2 PF13365.6 EMC86251.1 - 6.5e-06 27.1 0.0 2.5e-05 25.2 0.0 2.0 2 0 0 2 2 2 1 Trypsin-like peptidase domain cEGF PF12662.7 EMC86251.1 - 5.5e-05 23.0 6.6 0.00057 19.8 3.3 3.1 2 0 0 2 2 2 1 Complement Clr-like EGF-like EGF_CA PF07645.15 EMC86251.1 - 9.6e-05 22.5 8.7 0.00016 21.8 6.9 2.5 2 0 0 2 2 2 1 Calcium-binding EGF domain CUB_2 PF02408.20 EMC86251.1 - 0.0029 17.4 0.2 3.7 7.3 0.0 2.9 3 0 0 3 3 3 2 CUB-like domain EGF PF00008.27 EMC86251.1 - 0.0073 16.6 5.8 0.042 14.2 5.8 2.5 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 EMC86251.1 - 0.052 14.2 6.5 0.37 11.5 6.5 2.7 1 0 0 1 1 1 0 Human growth factor-like EGF DUF1986 PF09342.11 EMC86251.1 - 0.11 12.9 0.0 0.27 11.6 0.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1986) Lipocalin_7 PF14651.6 EMC86252.1 - 0.021 14.8 0.0 0.031 14.2 0.0 1.2 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family Cadherin PF00028.17 EMC86253.1 - 2.6e-12 47.0 0.0 5.3e-06 26.8 0.0 2.7 3 0 0 3 3 3 2 Cadherin domain Laminin_G_3 PF13385.6 EMC86253.1 - 3.2e-06 27.4 0.0 9.1e-06 25.9 0.0 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 EMC86253.1 - 0.036 14.6 0.0 0.11 13.1 0.0 1.8 1 0 0 1 1 1 0 Laminin G domain Mito_carr PF00153.27 EMC86254.1 - 4.7e-63 209.1 0.3 7.8e-21 73.8 0.2 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein TPR_1 PF00515.28 EMC86255.1 - 6.6e-25 85.9 1.1 3.6e-06 26.6 0.0 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 EMC86255.1 - 1.5e-20 71.6 5.1 0.00017 21.4 0.4 5.9 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_11 PF13414.6 EMC86255.1 - 2.7e-18 65.4 0.2 3.9e-05 23.2 0.1 5.1 3 1 3 6 6 6 3 TPR repeat TPR_8 PF13181.6 EMC86255.1 - 1.1e-16 59.5 0.0 0.00091 19.3 0.0 5.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 EMC86255.1 - 1.3e-16 60.9 2.6 4.1e-06 27.3 0.4 4.7 2 2 1 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 EMC86255.1 - 3.4e-15 55.4 12.4 0.012 16.4 0.2 7.6 5 1 2 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 EMC86255.1 - 8.7e-14 50.8 1.5 0.05 14.0 0.0 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 EMC86255.1 - 2.1e-12 47.3 2.7 0.0029 18.1 0.0 4.6 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EMC86255.1 - 1.1e-10 41.6 4.9 0.0001 22.5 0.1 4.0 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 EMC86255.1 - 1.1e-09 37.6 1.7 0.28 11.3 0.0 6.0 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_9 PF13371.6 EMC86255.1 - 1.7e-07 31.2 5.3 0.066 13.4 0.2 3.5 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_20 PF14561.6 EMC86255.1 - 4.6e-07 30.1 1.3 0.34 11.3 0.0 4.7 3 2 2 5 5 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 EMC86255.1 - 1.2e-05 25.0 4.2 0.055 13.3 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 EMC86255.1 - 1.8e-05 25.0 3.8 4.6 8.1 0.1 6.3 7 0 0 7 7 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC86255.1 - 1.9e-05 24.8 1.8 0.073 13.3 0.1 2.8 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 MAS20 PF02064.15 EMC86255.1 - 0.025 14.7 0.1 5.6 7.1 0.0 3.1 2 2 0 3 3 3 0 MAS20 protein import receptor DUF1641 PF07849.11 EMC86255.1 - 0.052 13.4 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) Secretin_N_2 PF07655.13 EMC86255.1 - 0.071 13.7 0.1 0.17 12.4 0.1 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain BTAD PF03704.17 EMC86255.1 - 0.26 11.7 4.0 2.8 8.4 0.0 3.8 4 1 0 4 4 4 0 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.6 EMC86255.1 - 0.4 10.8 1.5 45 4.2 0.0 3.8 4 0 0 4 4 3 0 Fis1 C-terminal tetratricopeptide repeat SHNi-TPR PF10516.9 EMC86255.1 - 0.46 10.0 2.2 34 4.0 0.0 4.1 5 0 0 5 5 5 0 SHNi-TPR Crystall PF00030.19 EMC86256.1 - 3.1e-30 104.2 0.3 7.7e-18 64.5 0.0 2.0 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.13 EMC86256.1 - 1.8e-08 34.2 0.1 0.0041 17.0 0.0 2.6 1 1 2 3 3 3 3 Peptidase inhibitor family I36 Crystall_3 PF08964.10 EMC86256.1 - 5.8e-06 26.4 0.8 0.0027 17.8 0.5 2.3 1 1 1 2 2 2 2 Beta/Gamma crystallin IL4_i_Ig PF18258.1 EMC86256.1 - 0.0026 17.9 0.7 0.25 11.6 0.1 2.9 2 2 1 3 3 3 1 Interleukin-4 inducing immunoglobulin-binding domain Pkinase_Tyr PF07714.17 EMC86257.1 - 1.8e-97 325.7 0.0 2.7e-97 325.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.19 EMC86257.1 - 3.6e-59 199.8 0.1 5.5e-59 199.2 0.1 1.3 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.25 EMC86257.1 - 4.6e-48 163.9 0.0 6.8e-48 163.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 EMC86257.1 - 7.5e-25 87.1 0.1 2e-12 47.3 0.0 2.7 3 0 0 3 3 2 2 Fibronectin type III domain SAM_1 PF00536.30 EMC86257.1 - 4.7e-21 75.0 0.0 1.1e-20 73.8 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC86257.1 - 1.2e-17 63.8 0.0 2.3e-17 62.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) EphA2_TM PF14575.6 EMC86257.1 - 1e-14 55.2 0.0 2e-14 54.2 0.0 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Pur_ac_phosph_N PF16656.5 EMC86257.1 - 1.2e-07 32.2 0.0 0.00015 22.3 0.0 2.9 2 1 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Ephrin_rec_like PF07699.13 EMC86257.1 - 2.1e-06 27.4 3.3 2.1e-06 27.4 3.3 3.4 2 1 1 3 3 3 1 Putative ephrin-receptor like Haspin_kinase PF12330.8 EMC86257.1 - 0.0085 15.1 0.0 0.013 14.4 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EMC86257.1 - 0.024 14.0 0.0 0.05 13.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Tissue_fac PF01108.17 EMC86257.1 - 0.032 14.1 0.0 0.86 9.5 0.0 2.4 2 0 0 2 2 2 0 Tissue factor Tudor_4 PF18358.1 EMC86257.1 - 0.14 11.8 0.1 20 4.9 0.0 2.7 2 0 0 2 2 2 0 Histone methyltransferase Tudor domain FAM131 PF15010.6 EMC86258.1 - 8.3e-100 334.5 7.9 1.7e-99 333.5 7.9 1.4 1 1 0 1 1 1 1 Putative cell signalling Peptidase_C14 PF00656.22 EMC86259.1 - 1.1e-43 150.0 0.9 5.7e-43 147.7 0.2 2.0 2 0 0 2 2 2 1 Caspase domain CARD PF00619.21 EMC86259.1 - 1.6e-19 69.7 0.8 3.6e-19 68.6 0.8 1.6 1 0 0 1 1 1 1 Caspase recruitment domain CARD_2 PF16739.5 EMC86259.1 - 3.6e-06 26.9 1.0 7.1e-06 25.9 1.0 1.4 1 0 0 1 1 1 1 Caspase recruitment domain TMEM51 PF15345.6 EMC86260.1 - 0.078 12.8 0.6 0.083 12.7 0.6 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 Rap_GAP PF02145.15 EMC86261.1 - 2.1e-65 219.8 0.0 3.4e-65 219.1 0.0 1.3 1 0 0 1 1 1 1 Rap/ran-GAP GoLoco PF02188.17 EMC86261.1 - 0.0012 18.3 2.4 0.0024 17.4 2.4 1.6 1 0 0 1 1 1 1 GoLoco motif DSBA PF01323.20 EMC86262.1 - 3.1e-48 164.1 0.0 3.5e-48 164.0 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Peptidase_M13_N PF05649.13 EMC86263.1 - 2.2e-90 304.1 0.0 2.7e-90 303.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 EMC86263.1 - 3.7e-50 170.4 0.1 7.9e-50 169.3 0.1 1.6 1 0 0 1 1 1 1 Peptidase family M13 Ank_2 PF12796.7 EMC86264.1 - 6e-21 74.8 1.9 3.1e-10 40.5 0.2 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ion_trans PF00520.31 EMC86264.1 - 8.6e-20 71.0 22.1 8.6e-20 71.0 22.1 2.2 1 1 1 2 2 2 1 Ion transport protein Ank_5 PF13857.6 EMC86264.1 - 1.1e-17 63.9 2.4 0.021 15.1 0.1 5.3 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC86264.1 - 4.4e-17 62.2 0.2 0.00012 22.6 0.0 4.8 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC86264.1 - 7.9e-17 59.6 2.2 0.00011 22.3 0.0 6.0 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 EMC86264.1 - 1.8e-13 50.3 1.2 0.0034 17.8 0.1 5.1 5 0 0 5 5 5 3 Ankyrin repeat OKR_DC_1 PF01276.20 EMC86264.1 - 0.14 10.8 0.0 0.22 10.2 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain Pkinase_Tyr PF07714.17 EMC86266.1 - 1.7e-95 319.2 0.0 2.3e-95 318.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.19 EMC86266.1 - 3.9e-70 235.5 0.1 6e-70 234.9 0.1 1.3 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.25 EMC86266.1 - 3.6e-46 157.7 0.0 5.4e-46 157.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 EMC86266.1 - 3.4e-25 88.2 0.0 7.8e-15 55.0 0.0 3.0 3 0 0 3 3 2 2 Fibronectin type III domain SAM_2 PF07647.17 EMC86266.1 - 1.9e-20 72.7 0.0 3.6e-20 71.8 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EMC86266.1 - 9.2e-19 67.6 0.1 2.1e-18 66.5 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) EphA2_TM PF14575.6 EMC86266.1 - 2.7e-18 66.6 0.0 5.2e-18 65.7 0.0 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Ephrin_rec_like PF07699.13 EMC86266.1 - 2e-05 24.3 0.8 2e-05 24.3 0.8 2.5 2 0 0 2 2 2 1 Putative ephrin-receptor like Pur_ac_phosph_N PF16656.5 EMC86266.1 - 0.00039 20.9 0.1 0.0013 19.2 0.1 1.9 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Y_Y_Y PF07495.13 EMC86266.1 - 0.024 14.6 0.1 0.092 12.7 0.1 1.9 2 0 0 2 2 2 0 Y_Y_Y domain Kdo PF06293.14 EMC86266.1 - 0.026 13.9 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EMC86266.1 - 0.044 12.7 0.0 0.08 11.9 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain cEGF PF12662.7 EMC86266.1 - 0.048 13.6 0.2 0.17 11.9 0.2 1.9 1 0 0 1 1 1 0 Complement Clr-like EGF-like Pkinase_fungal PF17667.1 EMC86266.1 - 0.099 11.4 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase TENA_THI-4 PF03070.16 EMC86267.1 - 0.058 13.2 0.1 0.14 11.9 0.0 1.6 2 0 0 2 2 2 0 TENA/THI-4/PQQC family RVT_1 PF00078.27 EMC86267.1 - 0.078 12.5 0.0 0.8 9.2 0.0 2.2 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) C1-set PF07654.15 EMC86269.1 - 1.9e-17 63.4 0.0 2.3e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.6 EMC86269.1 - 7e-05 23.4 0.0 9e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC86269.1 - 0.053 13.7 0.1 0.073 13.2 0.1 1.2 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 EMC86270.1 - 3.8e-09 36.7 0.4 4.1e-09 36.6 0.4 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC86270.1 - 0.00031 21.3 0.2 0.00073 20.1 0.2 1.6 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC86270.1 - 0.0069 16.5 0.1 0.011 15.9 0.1 1.3 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC86270.1 - 0.0087 16.4 0.3 0.028 14.8 0.3 1.8 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC86270.1 - 0.018 15.1 0.2 0.02 14.9 0.2 1.3 1 1 0 1 1 1 0 Immunoglobulin I-set domain Trypsin PF00089.26 EMC86271.1 - 0.00022 21.1 0.0 0.00025 20.9 0.0 1.0 1 0 0 1 1 1 1 Trypsin FGF PF00167.18 EMC86272.1 - 5.6e-36 123.4 1.2 6.2e-36 123.3 1.2 1.0 1 0 0 1 1 1 1 Fibroblast growth factor Ig_3 PF13927.6 EMC86273.1 - 5.9e-14 52.4 0.1 1.9e-08 34.8 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 EMC86273.1 - 6.4e-12 45.6 0.0 2.3e-06 27.8 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC86273.1 - 5.4e-11 42.4 0.1 8e-08 32.3 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 EMC86273.1 - 7.6e-11 42.0 0.0 5.1e-05 23.4 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 EMC86273.1 - 2.2e-08 34.2 0.6 1.8e-05 24.9 0.0 2.9 2 2 0 2 2 2 2 Immunoglobulin V-set domain Ig_4 PF16680.5 EMC86273.1 - 9.5e-07 29.0 0.2 0.021 15.1 0.0 2.7 2 1 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 EMC86273.1 - 0.00018 21.8 0.5 0.07 13.5 0.0 2.8 2 1 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain HTH_5 PF01022.20 EMC86273.1 - 0.017 15.0 0.6 0.034 14.0 0.0 1.8 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family Gag_p30 PF02093.16 EMC86274.1 - 6.4e-24 84.6 0.0 7e-24 84.5 0.0 1.0 1 0 0 1 1 1 1 Gag P30 core shell protein DUF4315 PF14193.6 EMC86274.1 - 0.18 11.8 2.7 0.82 9.7 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4315) PARP PF00644.20 EMC86275.1 - 2.5e-14 53.3 0.3 6.1e-14 52.1 0.3 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain ARTD15_N PF18084.1 EMC86275.1 - 3.6e-05 23.9 0.1 0.00013 22.2 0.1 2.0 1 0 0 1 1 1 1 ARTD15 N-terminal domain Yae1_N PF09811.9 EMC86276.1 - 3.7e-17 61.7 61.8 1.8e+04 -26.6 61.8 5.8 1 1 0 1 1 1 0 Essential protein Yae1, N terminal eRF1_1 PF03463.15 EMC86278.1 - 1.3e-52 177.2 0.1 2.1e-52 176.5 0.1 1.3 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.15 EMC86278.1 - 1.2e-36 126.0 0.1 1.9e-36 125.3 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EMC86278.1 - 3.2e-26 92.0 0.1 9.1e-26 90.6 0.0 1.8 2 0 0 2 2 2 1 eRF1 domain 3 Integrin_alpha2 PF08441.12 EMC86279.1 - 6.6e-47 160.4 8.3 1e-46 159.8 8.3 1.2 1 0 0 1 1 1 1 Integrin alpha VWA PF00092.28 EMC86279.1 - 8.6e-41 140.1 0.6 1.4e-40 139.4 0.6 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain FG-GAP PF01839.23 EMC86279.1 - 4.6e-17 61.8 9.3 3.7e-08 33.3 0.8 3.8 3 0 0 3 3 3 2 FG-GAP repeat VWA_2 PF13519.6 EMC86279.1 - 4.3e-14 53.1 0.2 1.6e-13 51.2 0.1 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain VCBS PF13517.6 EMC86279.1 - 5.7e-07 30.0 5.2 0.0002 21.9 2.2 3.6 3 1 1 4 4 4 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.6 EMC86279.1 - 5.5e-06 26.5 0.3 0.17 12.2 0.2 4.5 4 0 0 4 4 4 2 FG-GAP repeat LYRIC PF15686.5 EMC86279.1 - 0.023 14.3 0.4 0.037 13.6 0.4 1.3 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family Integrin_alpha PF00357.20 EMC86279.1 - 0.039 13.9 3.8 0.09 12.8 3.8 1.7 1 0 0 1 1 1 0 Integrin alpha cytoplasmic region MoaE PF02391.17 EMC86280.1 - 2.2e-40 137.5 0.2 2.5e-40 137.3 0.2 1.1 1 0 0 1 1 1 1 MoaE protein PCNA_C PF02747.15 EMC86280.1 - 0.12 12.6 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Proliferating cell nuclear antigen, C-terminal domain Kazal_2 PF07648.15 EMC86281.1 - 6e-37 125.5 39.5 3.2e-14 52.8 3.4 4.5 5 0 0 5 5 5 3 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EMC86281.1 - 1.8e-17 63.1 35.8 1.2e-06 28.4 7.9 4.0 3 0 0 3 3 3 3 Kazal-type serine protease inhibitor domain FOLN PF09289.10 EMC86281.1 - 1.9e-07 31.1 13.6 1.9e-07 31.1 13.6 4.7 5 0 0 5 5 5 2 Follistatin/Osteonectin-like EGF domain ETC_C1_NDUFA4 PF04800.12 EMC86282.1 - 1.2e-38 131.2 2.1 1.2e-38 131.2 2.1 1.4 2 0 0 2 2 2 1 ETC complex I subunit conserved region DUF1775 PF07987.11 EMC86282.1 - 0.013 15.7 0.7 2.8 8.2 0.1 2.2 1 1 1 2 2 2 0 Domain of unkown function (DUF1775) DUF2188 PF09954.9 EMC86282.1 - 0.017 15.2 0.3 0.041 14.0 0.1 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2188) Arf PF00025.21 EMC86283.1 - 1.3e-29 102.9 0.0 1.5e-29 102.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EMC86283.1 - 3.3e-09 37.0 0.0 4.2e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EMC86283.1 - 9.4e-07 28.4 0.0 1.2e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EMC86283.1 - 1.2e-06 28.2 0.0 1.5e-06 27.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EMC86283.1 - 0.00016 21.1 0.0 0.00019 20.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EMC86283.1 - 0.0008 18.7 0.8 0.07 12.3 0.0 2.1 1 1 1 2 2 2 1 G-protein alpha subunit MMR_HSR1 PF01926.23 EMC86283.1 - 0.00089 19.3 0.0 0.0031 17.6 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA PF00004.29 EMC86283.1 - 0.0024 18.3 0.0 0.0036 17.7 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EMC86283.1 - 0.01 16.0 0.0 0.01 16.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EMC86283.1 - 0.012 15.9 0.1 0.016 15.5 0.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EMC86283.1 - 0.012 16.0 0.1 0.021 15.2 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain cobW PF02492.19 EMC86283.1 - 0.015 14.9 0.1 0.2 11.3 0.1 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 EMC86283.1 - 0.018 15.5 0.2 0.18 12.3 0.2 2.0 1 1 0 1 1 1 0 ABC transporter NACHT PF05729.12 EMC86283.1 - 0.019 14.9 0.1 0.29 11.1 0.1 2.1 1 1 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 EMC86283.1 - 0.046 13.2 0.0 0.064 12.8 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EMC86283.1 - 0.068 13.6 0.1 0.16 12.4 0.1 1.6 1 1 0 1 1 1 0 RNA helicase AAA_14 PF13173.6 EMC86283.1 - 0.069 13.2 0.0 0.094 12.8 0.0 1.1 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 EMC86283.1 - 0.069 12.9 0.1 3.1 7.5 0.1 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 EMC86283.1 - 0.11 12.3 0.0 3.3 7.5 0.1 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation HSP20 PF00011.21 EMC86284.1 - 1.4e-15 57.3 0.0 2.1e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EMC86284.1 - 0.0027 17.2 0.0 0.0036 16.8 0.0 1.2 1 0 0 1 1 1 1 HSP20-like domain found in ArsA HrpB1_HrpK PF09613.10 EMC86284.1 - 0.058 13.0 0.0 0.092 12.4 0.0 1.2 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB1_HrpK) BAR_3_WASP_bdg PF10456.9 EMC86285.1 - 6.4e-108 359.6 6.8 8e-108 359.3 6.8 1.1 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein PX PF00787.24 EMC86285.1 - 3.6e-22 78.5 0.4 1e-21 77.0 0.0 2.0 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 EMC86285.1 - 0.0014 18.2 6.9 0.0041 16.7 2.1 2.3 2 0 0 2 2 2 2 Vps5 C terminal like HBM PF16591.5 EMC86285.1 - 0.0084 15.6 0.2 0.027 13.9 0.0 1.7 1 1 0 1 1 1 1 Helical bimodular sensor domain BAR PF03114.18 EMC86285.1 - 0.11 12.1 6.7 0.029 14.0 3.4 1.7 2 0 0 2 2 2 0 BAR domain IGFBP PF00219.18 EMC86286.1 - 7.3e-09 36.2 20.8 7.3e-09 36.2 20.8 2.4 2 0 0 2 2 2 1 Insulin-like growth factor binding protein Trypsin PF00089.26 EMC86287.1 - 6.9e-70 235.3 1.6 7.9e-70 235.1 1.6 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EMC86287.1 - 9.9e-06 26.5 0.0 1.6e-05 25.8 0.0 1.3 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 EMC86287.1 - 0.0013 19.1 0.0 0.0023 18.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) WD40 PF00400.32 EMC86288.1 - 0.00052 20.8 1.0 0.43 11.5 0.0 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC86288.1 - 0.0018 18.5 0.0 1 9.7 0.0 2.1 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain GSHPx PF00255.19 EMC86289.1 - 3.5e-36 123.1 0.0 4.8e-36 122.6 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 EMC86289.1 - 1.7e-06 27.9 0.0 2.9e-06 27.2 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA family ABC2_membrane_6 PF06182.11 EMC86289.1 - 0.13 12.0 0.6 0.2 11.4 0.6 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein HA2 PF04408.23 EMC86290.1 - 5.6e-16 58.8 0.0 5.6e-16 58.8 0.0 2.7 2 1 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EMC86290.1 - 4.4e-15 55.8 0.1 4.6e-14 52.5 0.0 2.6 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EMC86290.1 - 5.7e-13 49.2 0.4 2.1e-12 47.4 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EMC86290.1 - 1.2e-10 41.4 0.0 3.1e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EMC86290.1 - 7.8e-06 26.2 0.2 2.8e-05 24.4 0.2 1.9 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EMC86290.1 - 0.013 16.0 1.6 0.87 10.1 0.0 2.8 2 0 0 2 2 2 0 ABC transporter T2SSE PF00437.20 EMC86290.1 - 0.021 13.9 0.1 0.048 12.7 0.1 1.6 1 1 0 1 1 1 0 Type II/IV secretion system protein AAA_7 PF12775.7 EMC86290.1 - 0.047 13.2 0.1 0.81 9.2 0.0 2.5 2 1 0 2 2 2 0 P-loop containing dynein motor region ATPase PF06745.13 EMC86290.1 - 0.12 11.7 0.0 0.3 10.4 0.0 1.6 1 0 0 1 1 1 0 KaiC PAP2 PF01569.21 EMC86291.1 - 1.2e-27 96.3 1.6 1.2e-27 96.3 1.6 1.5 2 0 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 EMC86291.1 - 0.0074 16.8 2.8 0.0074 16.8 2.8 2.2 2 1 1 3 3 3 1 PAP2 superfamily C-terminal COX4 PF02936.14 EMC86291.1 - 0.03 14.3 0.0 0.051 13.6 0.0 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV TPPK_C PF12555.8 EMC86291.1 - 0.11 12.5 0.7 6.9 6.8 0.2 2.6 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal DEAD PF00270.29 EMC86293.1 - 2.7e-50 170.6 0.0 5.5e-50 169.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC86293.1 - 3.5e-32 111.0 0.2 7.1e-31 106.8 0.2 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC86293.1 - 0.0039 17.2 0.0 0.0093 16.0 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EMC86293.1 - 0.11 11.9 0.1 0.96 8.7 0.0 2.1 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit PSP1 PF04468.12 EMC86294.1 - 0.077 13.3 1.3 0.14 12.4 0.1 2.0 2 0 0 2 2 2 0 PSP1 C-terminal conserved region fn3 PF00041.21 EMC86295.1 - 1e-24 86.6 4.1 1.2e-08 35.1 0.1 4.2 4 0 0 4 4 4 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 EMC86295.1 - 0.00028 21.4 11.5 0.57 10.8 0.0 3.7 2 1 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Big_5 PF13205.6 EMC86295.1 - 0.0094 16.6 2.2 0.017 15.8 0.1 2.3 2 0 0 2 2 2 1 Bacterial Ig-like domain Glyco_hydro_36C PF16874.5 EMC86295.1 - 0.054 14.0 0.0 0.85 10.2 0.0 2.9 4 0 0 4 4 4 0 Glycosyl hydrolase family 36 C-terminal domain fn3_4 PF16794.5 EMC86295.1 - 8.7 6.3 7.6 6.3 6.8 0.1 3.8 3 3 1 4 4 4 0 Fibronectin-III type domain fn3 PF00041.21 EMC86296.1 - 1.2e-31 108.9 9.6 5.8e-09 36.2 0.3 5.7 5 0 0 5 5 5 4 Fibronectin type III domain Lep_receptor_Ig PF06328.11 EMC86296.1 - 5.5e-29 100.0 0.5 1.8e-28 98.3 0.4 2.0 2 0 0 2 2 2 1 Ig-like C2-type domain EpoR_lig-bind PF09067.10 EMC86296.1 - 8.6e-06 25.9 0.0 2.2e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding IL6Ra-bind PF09240.10 EMC86296.1 - 0.00035 20.9 1.2 0.00085 19.7 0.1 2.2 2 0 0 2 2 2 1 Interleukin-6 receptor alpha chain, binding fn3_2 PF16893.5 EMC86296.1 - 0.0035 17.5 0.0 0.024 14.8 0.0 2.4 2 0 0 2 2 2 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 EMC86296.1 - 0.0047 17.5 9.3 0.051 14.1 0.0 3.8 4 0 0 4 4 4 2 Purple acid Phosphatase, N-terminal domain ObR_Ig PF18589.1 EMC86296.1 - 0.043 14.2 0.0 1.4 9.3 0.0 2.7 1 1 0 1 1 1 0 Obesity receptor immunoglobulin like domain IL4Ra_N PF09238.10 EMC86296.1 - 0.12 12.7 0.5 1.7 9.0 0.2 2.6 2 0 0 2 2 2 0 Interleukin-4 receptor alpha chain, N-terminal DUF3377 PF11857.8 EMC86296.1 - 0.21 11.5 0.3 0.49 10.3 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) GTA_holin_3TM PF11351.8 EMC86297.1 - 0.59 10.7 8.0 6.3 7.4 0.1 2.6 2 0 0 2 2 2 0 Holin of 3TMs, for gene-transfer release Acetyltransf_1 PF00583.25 EMC86300.1 - 2.4e-10 40.7 0.0 3.1e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMC86300.1 - 8.1e-08 32.3 0.0 1.1e-07 31.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMC86300.1 - 2.6e-07 31.0 0.0 3.8e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EMC86300.1 - 0.11 12.7 0.0 0.14 12.3 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DSPc PF00782.20 EMC86301.1 - 1.9e-38 131.3 0.0 2.4e-38 131.0 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC86301.1 - 0.099 12.2 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase AAA PF00004.29 EMC86302.1 - 7.2e-44 149.4 0.0 1.3e-43 148.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMC86302.1 - 6.3e-12 45.1 0.1 1.5e-11 43.9 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EMC86302.1 - 7.1e-10 38.7 0.6 1.4e-09 37.8 0.0 1.8 2 0 0 2 2 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 EMC86302.1 - 6.2e-07 30.0 0.1 0.00051 20.5 0.1 2.6 1 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EMC86302.1 - 4.2e-06 26.8 0.2 0.00011 22.2 0.1 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EMC86302.1 - 6e-06 26.5 0.0 7.2e-05 23.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EMC86302.1 - 7.1e-06 26.3 0.2 0.0026 18.1 0.0 2.6 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 EMC86302.1 - 1.8e-05 24.5 0.0 4.6e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EMC86302.1 - 0.00049 20.6 0.0 0.0019 18.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain Prot_ATP_OB_N PF17758.1 EMC86302.1 - 0.00053 19.6 0.2 0.0019 17.8 0.0 1.9 2 0 0 2 2 2 1 Proteasomal ATPase OB N-terminal domain AAA_33 PF13671.6 EMC86302.1 - 0.0014 18.8 0.0 0.0029 17.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EMC86302.1 - 0.003 17.1 0.0 0.0058 16.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region DUF815 PF05673.13 EMC86302.1 - 0.0032 16.7 0.0 0.012 14.8 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_3 PF07726.11 EMC86302.1 - 0.0056 16.6 0.0 0.022 14.6 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 EMC86302.1 - 0.007 16.4 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EMC86302.1 - 0.0074 16.3 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EMC86302.1 - 0.0074 16.0 0.0 0.017 14.8 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 EMC86302.1 - 0.0083 16.5 0.0 0.02 15.2 0.0 1.7 1 0 0 1 1 1 1 RNA helicase TIP49 PF06068.13 EMC86302.1 - 0.01 15.1 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 EMC86302.1 - 0.011 15.1 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Thymidylate_kin PF02223.17 EMC86302.1 - 0.021 14.5 0.1 1.6 8.4 0.0 2.4 2 0 0 2 2 2 0 Thymidylate kinase AAA_24 PF13479.6 EMC86302.1 - 0.022 14.5 0.0 0.058 13.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EMC86302.1 - 0.041 13.2 0.1 0.5 9.7 0.0 2.5 3 0 0 3 3 3 0 KaiC NACHT PF05729.12 EMC86302.1 - 0.052 13.5 0.0 0.18 11.7 0.0 1.8 1 1 1 2 2 2 0 NACHT domain AAA_11 PF13086.6 EMC86302.1 - 0.076 12.8 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EMC86302.1 - 0.084 12.4 0.0 0.22 11.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EMC86302.1 - 0.11 12.4 0.0 0.8 9.6 0.0 2.4 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_28 PF13521.6 EMC86302.1 - 0.12 12.6 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EMC86302.1 - 0.15 11.5 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein ERO1 PF04137.15 EMC86303.1 - 4.8e-117 391.1 0.0 5.5e-117 390.9 0.0 1.0 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) DUF1084 PF06454.11 EMC86304.1 - 0.022 14.1 13.5 0.055 12.8 13.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1084) DUF389 PF04087.14 EMC86304.1 - 0.15 12.1 3.4 0.13 12.3 0.9 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF389) Thioredoxin_6 PF13848.6 EMC86305.1 - 4.7e-24 85.3 0.0 1.7e-20 73.7 0.0 3.1 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin PF00085.20 EMC86305.1 - 8.7e-13 48.2 0.0 5.5e-12 45.6 0.0 2.3 3 0 0 3 3 3 1 Thioredoxin FAM176 PF14851.6 EMC86305.1 - 0.72 9.5 3.6 1.5 8.5 3.6 1.5 1 0 0 1 1 1 0 FAM176 family Ldl_recept_b PF00058.17 EMC86306.1 - 2.9e-34 117.3 0.4 3.7e-13 49.7 0.0 5.1 5 0 0 5 5 5 3 Low-density lipoprotein receptor repeat class B EGF_CA PF07645.15 EMC86306.1 - 2.3e-25 88.5 44.9 2e-10 40.7 4.2 5.0 4 0 0 4 4 4 4 Calcium-binding EGF domain EGF_3 PF12947.7 EMC86306.1 - 8.9e-25 86.6 50.8 1e-09 38.4 9.0 4.8 4 0 0 4 4 4 4 EGF domain cEGF PF12662.7 EMC86306.1 - 4e-19 68.2 34.1 3.1e-05 23.8 1.2 5.1 4 0 0 4 4 4 4 Complement Clr-like EGF-like G2F PF07474.12 EMC86306.1 - 9.6e-17 61.4 0.1 1.3e-16 60.9 0.1 1.2 1 0 0 1 1 1 1 G2F domain Thyroglobulin_1 PF00086.18 EMC86306.1 - 2.4e-16 59.2 3.3 2.4e-16 59.2 3.3 3.2 2 1 1 3 3 3 1 Thyroglobulin type-1 repeat hEGF PF12661.7 EMC86306.1 - 3e-09 37.2 44.6 0.00055 20.5 6.9 6.3 5 1 0 5 5 5 4 Human growth factor-like EGF EGF PF00008.27 EMC86306.1 - 5.5e-09 36.2 54.6 6.3e-05 23.2 11.1 5.8 5 0 0 5 5 4 4 EGF-like domain FXa_inhibition PF14670.6 EMC86306.1 - 2e-05 24.8 59.0 0.00059 20.1 6.7 5.1 4 1 1 5 5 4 4 Coagulation Factor Xa inhibitory site SGL PF08450.12 EMC86306.1 - 0.00011 21.9 0.0 0.0012 18.5 0.0 3.0 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region EGF_MSP1_1 PF12946.7 EMC86306.1 - 0.0014 18.7 42.3 0.077 13.1 2.9 4.6 4 0 0 4 4 4 3 MSP1 EGF domain 1 Arylesterase PF01731.20 EMC86306.1 - 0.061 13.5 0.0 31 4.8 0.0 3.1 4 0 0 4 4 3 0 Arylesterase DR2241 PF18069.1 EMC86306.1 - 0.063 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 DR2241 stabilising domain RLL PF10036.9 EMC86307.1 - 6.3e-83 278.6 1.6 7e-83 278.4 1.6 1.0 1 0 0 1 1 1 1 RNA transcription, translation and transport factor protein Cactin_mid PF10312.9 EMC86307.1 - 0.0011 18.7 0.2 0.0016 18.2 0.2 1.1 1 0 0 1 1 1 1 Conserved mid region of cactin G-gamma PF00631.22 EMC86308.1 - 7e-20 70.8 0.0 7.9e-20 70.6 0.0 1.0 1 0 0 1 1 1 1 GGL domain CP12 PF02672.15 EMC86308.1 - 0.039 14.7 0.1 0.049 14.4 0.1 1.2 1 0 0 1 1 1 0 CP12 domain FtsX_ECD PF18075.1 EMC86308.1 - 0.046 14.4 0.1 0.056 14.1 0.1 1.0 1 0 0 1 1 1 0 FtsX extracellular domain CHASE8 PF17152.4 EMC86308.1 - 0.092 13.0 0.0 0.1 12.8 0.0 1.1 1 0 0 1 1 1 0 Periplasmic sensor domain DUF997 PF06196.12 EMC86310.1 - 0.24 11.4 1.8 0.29 11.2 1.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF997) CcmD PF04995.14 EMC86310.1 - 0.32 11.1 1.9 0.49 10.5 1.9 1.4 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) Mab-21 PF03281.14 EMC86311.1 - 4.9e-12 45.7 0.9 7.8e-10 38.5 0.4 2.2 1 1 0 2 2 2 2 Mab-21 protein Proteasome PF00227.26 EMC86312.1 - 9.6e-54 181.8 0.1 9.6e-54 181.8 0.1 1.3 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.9 EMC86312.1 - 2.2e-14 52.8 0.1 3.8e-14 52.1 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF5633 PF18656.1 EMC86312.1 - 0.64 10.0 3.4 14 5.6 0.8 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5633) zf-Tim10_DDP PF02953.15 EMC86313.1 - 1.7e-17 62.8 3.9 2.2e-17 62.5 3.9 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF2116 PF09889.9 EMC86313.1 - 0.021 14.8 1.0 0.031 14.3 1.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Ion_trans_2 PF07885.16 EMC86314.1 - 4.1e-34 116.4 16.5 9.3e-18 64.0 0.3 3.1 3 0 0 3 3 3 2 Ion channel DUF1104 PF06518.11 EMC86314.1 - 0.11 12.9 0.1 0.17 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1104) DUF2070 PF09843.9 EMC86314.1 - 1 7.6 7.9 0.49 8.6 0.1 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) RAMP4 PF06624.12 EMC86314.1 - 8.7 6.5 6.4 14 5.8 0.1 2.9 3 0 0 3 3 3 0 Ribosome associated membrane protein RAMP4 Mab-21 PF03281.14 EMC86315.1 - 8.1e-14 51.6 2.7 2.8e-12 46.6 2.1 2.2 1 1 1 2 2 2 2 Mab-21 protein TMEM51 PF15345.6 EMC86315.1 - 0.00051 20.0 0.0 0.00075 19.4 0.0 1.2 1 0 0 1 1 1 1 Transmembrane protein 51 Mab-21 PF03281.14 EMC86316.1 - 3.3e-10 39.7 1.3 9e-09 35.0 1.3 2.1 1 1 0 1 1 1 1 Mab-21 protein Pro_racemase PF05544.11 EMC86318.1 - 9.4e-78 261.5 0.0 1.1e-77 261.3 0.0 1.0 1 0 0 1 1 1 1 Proline racemase JAMP PF05571.12 EMC86319.1 - 7.9e-110 367.1 10.4 8.9e-110 366.9 10.4 1.0 1 0 0 1 1 1 1 JNK1/MAPK8-associated membrane protein GTPase_binding PF09027.10 EMC86319.1 - 0.083 12.9 0.1 0.18 11.8 0.1 1.5 1 0 0 1 1 1 0 GTPase binding DUF1949 PF09186.11 EMC86319.1 - 0.17 11.8 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1949) Calici_PP_N PF08405.11 EMC86319.1 - 4 6.2 6.3 2.2 7.0 0.2 2.4 2 1 1 3 3 3 0 Viral polyprotein N-terminal DHR10 PF18595.1 EMC86321.1 - 0.00088 19.3 9.6 0.0083 16.2 4.5 2.2 2 0 0 2 2 2 1 Designed helical repeat protein 10 domain Rogdi_lz PF10259.9 EMC86321.1 - 0.0097 15.4 3.1 0.034 13.6 0.2 2.1 2 0 0 2 2 2 1 Rogdi leucine zipper containing protein SHE3 PF17078.5 EMC86321.1 - 0.01 15.6 7.7 0.015 15.0 7.7 1.3 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 Matrilin_ccoil PF10393.9 EMC86321.1 - 0.012 15.5 6.3 0.94 9.4 0.5 2.8 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin ADIP PF11559.8 EMC86321.1 - 0.017 15.2 11.2 0.12 12.4 4.7 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF489 PF04356.12 EMC86321.1 - 0.02 14.9 2.5 0.02 14.9 0.9 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF489) ArAE_2_N PF10337.9 EMC86321.1 - 0.023 13.8 2.6 0.028 13.5 2.6 1.2 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal COG2 PF06148.11 EMC86321.1 - 0.024 14.7 1.9 0.024 14.7 1.9 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Filament PF00038.21 EMC86321.1 - 0.024 14.2 9.8 0.07 12.7 9.8 1.8 1 1 0 1 1 1 0 Intermediate filament protein Spc7 PF08317.11 EMC86321.1 - 0.027 13.3 14.6 0.037 12.9 5.9 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein YtxH PF12732.7 EMC86321.1 - 0.03 14.9 0.3 1.1 9.8 0.1 2.4 2 1 0 2 2 2 0 YtxH-like protein Vip3A_N PF12495.8 EMC86321.1 - 0.047 13.6 1.6 0.063 13.2 1.3 1.4 1 1 0 1 1 1 0 Vegetative insecticide protein 3A N terminal PI3K_P85_iSH2 PF16454.5 EMC86321.1 - 0.055 13.1 8.3 0.19 11.4 3.7 2.2 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain TPR_MLP1_2 PF07926.12 EMC86321.1 - 0.061 13.4 13.3 0.39 10.8 11.6 2.1 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF1640 PF07798.11 EMC86321.1 - 0.068 13.2 8.8 0.099 12.7 8.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) DUF730 PF05325.11 EMC86321.1 - 0.085 12.9 4.0 0.19 11.8 1.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF730) DUF4200 PF13863.6 EMC86321.1 - 0.1 13.0 12.8 0.25 11.7 12.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Methyltransf_28 PF02636.17 EMC86321.1 - 0.1 12.2 1.2 0.15 11.6 0.7 1.5 1 1 1 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase LIDHydrolase PF10230.9 EMC86321.1 - 0.11 12.0 0.1 0.17 11.4 0.1 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase LMP PF04778.12 EMC86321.1 - 0.11 12.4 6.3 0.14 12.1 2.0 2.2 1 1 1 2 2 2 0 LMP repeated region Nsp1_C PF05064.13 EMC86321.1 - 0.12 12.2 8.4 0.25 11.1 2.0 2.3 1 1 1 2 2 2 0 Nsp1-like C-terminal region Syntaxin-6_N PF09177.11 EMC86321.1 - 0.13 12.8 6.1 16 6.2 6.1 2.4 1 1 0 1 1 1 0 Syntaxin 6, N-terminal KfrA_N PF11740.8 EMC86321.1 - 0.13 12.9 7.6 0.66 10.7 2.4 2.4 1 1 0 2 2 2 0 Plasmid replication region DNA-binding N-term HMMR_N PF15905.5 EMC86321.1 - 0.16 11.4 14.1 0.34 10.3 14.1 1.5 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Prefoldin PF02996.17 EMC86321.1 - 0.18 11.8 16.4 0.1 12.5 2.2 3.9 1 1 3 4 4 4 0 Prefoldin subunit Jnk-SapK_ap_N PF09744.9 EMC86321.1 - 0.27 11.4 11.1 0.18 12.0 4.3 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF5082 PF16888.5 EMC86321.1 - 0.29 11.4 10.8 6.8 7.0 10.3 2.9 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) MscS_porin PF12795.7 EMC86321.1 - 0.36 10.4 11.5 0.21 11.1 4.9 2.2 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain WXG100 PF06013.12 EMC86321.1 - 0.36 11.1 3.7 32 4.8 2.3 3.0 2 1 0 2 2 2 0 Proteins of 100 residues with WXG APG6_N PF17675.1 EMC86321.1 - 0.38 11.3 15.0 2.4 8.7 6.7 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region PIN_8 PF18476.1 EMC86321.1 - 0.41 10.5 5.2 0.8 9.5 5.1 1.4 1 1 0 1 1 1 0 PIN like domain FlxA PF14282.6 EMC86321.1 - 0.46 10.5 7.8 0.54 10.3 3.1 2.4 2 1 0 2 2 2 0 FlxA-like protein TMPIT PF07851.13 EMC86321.1 - 0.47 9.6 8.0 1.5 8.0 5.5 2.0 1 1 1 2 2 2 0 TMPIT-like protein Phage_GPO PF05929.11 EMC86321.1 - 0.49 10.0 6.0 0.22 11.1 1.8 1.9 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase LMBR1 PF04791.16 EMC86321.1 - 0.5 9.2 3.3 0.58 9.0 3.3 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein JAKMIP_CC3 PF16034.5 EMC86321.1 - 0.51 10.3 9.5 0.19 11.7 4.8 2.1 1 1 1 2 2 2 0 JAKMIP CC3 domain DUF4795 PF16043.5 EMC86321.1 - 0.51 9.9 11.1 2 8.0 3.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) DUF725 PF05267.12 EMC86321.1 - 0.57 10.2 5.6 0.39 10.7 0.5 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF725) CENP-H PF05837.12 EMC86321.1 - 0.59 10.6 11.4 1.7 9.1 4.2 2.4 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Prefoldin_2 PF01920.20 EMC86321.1 - 0.66 10.0 15.6 3 7.8 3.5 3.2 2 2 1 3 3 3 0 Prefoldin subunit ING PF12998.7 EMC86321.1 - 0.77 10.4 9.4 3.1 8.5 4.4 2.8 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding XhlA PF10779.9 EMC86321.1 - 0.78 10.0 10.1 0.26 11.5 1.3 3.0 1 1 1 3 3 3 0 Haemolysin XhlA DUF1664 PF07889.12 EMC86321.1 - 0.8 9.7 6.2 4.4 7.4 1.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF2205 PF10224.9 EMC86321.1 - 1 9.4 8.3 2.3 8.3 0.6 3.1 2 1 1 3 3 3 0 Short coiled-coil protein Spc24 PF08286.11 EMC86321.1 - 1 9.6 9.8 5 7.4 3.3 2.7 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 ATG16 PF08614.11 EMC86321.1 - 1.3 9.2 11.0 1.3 9.2 3.9 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) CREPT PF16566.5 EMC86321.1 - 1.4 9.1 9.5 1.5 9.0 3.8 2.1 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour GTP-bdg_M PF16360.5 EMC86321.1 - 1.5 9.4 6.2 3.3 8.4 0.4 3.0 2 1 1 3 3 3 0 GTP-binding GTPase Middle Region DUF16 PF01519.16 EMC86321.1 - 3.1 8.3 8.1 4.7 7.7 1.7 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF16 ABC_tran_CTD PF16326.5 EMC86321.1 - 3.4 8.0 17.2 1.1 9.6 1.7 3.4 2 2 1 3 3 3 0 ABC transporter C-terminal domain YabA PF06156.13 EMC86321.1 - 3.5 8.3 7.9 49 4.6 7.1 2.6 1 1 0 1 1 1 0 Initiation control protein YabA SlyX PF04102.12 EMC86321.1 - 3.6 8.3 8.1 4.6 7.9 3.2 2.7 1 1 1 2 2 2 0 SlyX PCRF PF03462.18 EMC86321.1 - 4 7.2 10.5 3.7 7.4 1.3 2.1 1 1 1 2 2 2 0 PCRF domain AAA_lid_9 PF17871.1 EMC86321.1 - 4.1 7.4 9.8 1 9.3 1.9 2.6 1 1 2 3 3 3 0 AAA lid domain Cnn_1N PF07989.11 EMC86321.1 - 4.3 7.6 11.4 8.3 6.6 2.3 2.8 2 1 1 3 3 2 0 Centrosomin N-terminal motif 1 ZapB PF06005.12 EMC86321.1 - 6.6 7.3 13.4 5.7e+02 1.1 13.4 2.6 1 1 0 1 1 1 0 Cell division protein ZapB Pecanex_C PF05041.15 EMC86322.1 - 3.8e-27 95.4 0.0 7e-27 94.5 0.0 1.3 1 0 0 1 1 1 1 Pecanex protein (C-terminus) DUF3119 PF11317.8 EMC86322.1 - 0.39 11.0 3.6 0.31 11.3 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3119) adh_short PF00106.25 EMC86323.1 - 7.6e-47 159.3 0.0 9.4e-47 159.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC86323.1 - 2.7e-27 95.9 0.0 3.3e-27 95.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC86323.1 - 1.3e-08 35.0 0.1 2.1e-08 34.3 0.1 1.3 1 0 0 1 1 1 1 KR domain PP2C PF00481.21 EMC86324.1 - 1e-87 294.1 0.0 1.3e-87 293.7 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_C PF07830.13 EMC86324.1 - 1.3e-32 112.1 0.1 2.4e-32 111.2 0.1 1.5 1 0 0 1 1 1 1 Protein serine/threonine phosphatase 2C, C-terminal domain S6OS1 PF15676.5 EMC86325.1 - 3.1e-65 220.8 21.2 3.5e-65 220.6 21.2 1.0 1 0 0 1 1 1 1 Six6 opposite strand transcript 1 family SIX1_SD PF16878.5 EMC86326.1 - 1.1e-48 164.3 0.4 1.1e-47 161.1 0.0 2.1 2 0 0 2 2 2 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeodomain PF00046.29 EMC86326.1 - 4.4e-13 48.9 3.3 8.8e-13 47.9 1.1 2.3 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 EMC86326.1 - 7.2e-11 41.8 0.9 2e-10 40.4 0.9 1.7 1 0 0 1 1 1 1 Homeobox KN domain HTH_3 PF01381.22 EMC86326.1 - 0.023 14.7 0.0 0.047 13.7 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix Homez PF11569.8 EMC86326.1 - 0.056 12.9 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez YdaS_antitoxin PF15943.5 EMC86326.1 - 0.085 12.7 0.1 0.17 11.8 0.1 1.5 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT CENP-B_N PF04218.13 EMC86326.1 - 0.14 11.9 0.0 0.46 10.2 0.0 1.9 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain SIX1_SD PF16878.5 EMC86327.1 - 2.5e-49 166.4 0.1 3.7e-49 165.9 0.1 1.3 1 0 0 1 1 1 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeodomain PF00046.29 EMC86327.1 - 2.1e-08 33.9 2.1 3.3e-08 33.3 0.5 2.1 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 EMC86327.1 - 6.9e-06 25.9 0.4 1.5e-05 24.8 0.4 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 EMC86327.1 - 0.0053 16.2 0.1 0.013 14.9 0.1 1.6 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez HTH_3 PF01381.22 EMC86327.1 - 0.0071 16.4 0.0 0.025 14.6 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix YdaS_antitoxin PF15943.5 EMC86327.1 - 0.066 13.1 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Phage_mat-A PF03863.13 EMC86327.1 - 0.12 11.3 0.0 0.19 10.6 0.0 1.2 1 0 0 1 1 1 0 Phage maturation protein SIX1_SD PF16878.5 EMC86328.1 - 1.9e-40 137.8 0.7 6.4e-39 132.9 0.0 2.9 3 0 0 3 3 3 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeodomain PF00046.29 EMC86328.1 - 1.2e-13 50.7 1.2 2.4e-13 49.7 1.2 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC86328.1 - 7.5e-09 35.4 0.7 1.8e-08 34.1 0.7 1.7 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 EMC86328.1 - 0.14 11.7 0.0 0.32 10.5 0.0 1.6 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez MAT1 PF06391.13 EMC86329.1 - 3e-64 216.6 20.2 3.5e-64 216.4 20.2 1.0 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 LMBR1 PF04791.16 EMC86329.1 - 9.3 5.0 10.1 11 4.7 10.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Met_10 PF02475.16 EMC86330.1 - 5.1e-67 225.5 0.0 8.1e-67 224.8 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_15 PF09445.10 EMC86330.1 - 0.00012 21.7 0.0 0.00028 20.5 0.0 1.7 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase TRM PF02005.16 EMC86330.1 - 0.00094 18.5 0.0 0.002 17.3 0.0 1.5 2 0 0 2 2 2 1 N2,N2-dimethylguanosine tRNA methyltransferase MethyltransfD12 PF02086.15 EMC86330.1 - 0.0024 17.6 0.0 0.0046 16.7 0.0 1.4 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase tRNA_U5-meth_tr PF05958.11 EMC86330.1 - 0.036 13.0 0.0 0.18 10.8 0.0 1.8 2 0 0 2 2 2 0 tRNA (Uracil-5-)-methyltransferase PrmA PF06325.13 EMC86330.1 - 0.068 12.6 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) VASP_tetra PF08776.11 EMC86330.1 - 0.9 9.2 4.1 0.73 9.5 0.3 2.8 3 0 0 3 3 3 0 VASP tetramerisation domain Aa_trans PF01490.18 EMC86331.1 - 3.9e-74 249.8 38.1 4.6e-74 249.6 38.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Pkinase PF00069.25 EMC86332.1 - 5.8e-63 212.7 0.0 8.8e-63 212.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC86332.1 - 1.6e-36 126.0 0.0 2.3e-36 125.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 EMC86332.1 - 2.6e-31 107.3 30.3 5.2e-16 58.3 6.1 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C2 PF00168.30 EMC86332.1 - 6.6e-13 48.9 0.0 1.3e-12 47.9 0.0 1.5 1 0 0 1 1 1 1 C2 domain Pkinase_C PF00433.24 EMC86332.1 - 1.5e-08 35.2 0.2 2.8e-08 34.3 0.2 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 EMC86332.1 - 4.1e-05 23.1 0.0 0.00028 20.3 0.0 2.0 2 0 0 2 2 2 1 Kinase-like C1_2 PF03107.16 EMC86332.1 - 0.001 19.4 17.1 0.042 14.2 2.6 2.6 2 0 0 2 2 2 2 C1 domain FTA2 PF13095.6 EMC86332.1 - 0.0082 15.8 0.1 1.4 8.5 0.0 2.3 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EMC86332.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 EMC86332.1 - 0.14 11.7 0.0 0.31 10.6 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Haspin_kinase PF12330.8 EMC86332.1 - 0.15 10.9 0.0 0.25 10.2 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Zf_RING PF16744.5 EMC86332.1 - 2.3 8.4 17.0 3.6 7.8 6.8 2.5 2 0 0 2 2 2 0 KIAA1045 RING finger PAS_3 PF08447.12 EMC86333.1 - 4.7e-28 97.3 0.1 4.8e-22 78.1 0.1 2.5 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 EMC86333.1 - 5.9e-24 84.4 0.6 2.7e-20 72.6 0.1 2.6 2 0 0 2 2 2 2 PAS domain HIF-1a_CTAD PF08778.10 EMC86333.1 - 1.2e-21 76.0 0.4 2.7e-21 74.9 0.4 1.6 1 0 0 1 1 1 1 HIF-1 alpha C terminal transactivation domain PAS PF00989.25 EMC86333.1 - 5.4e-16 58.6 0.0 1.4e-07 31.5 0.0 2.5 2 0 0 2 2 2 2 PAS fold HIF-1 PF11413.8 EMC86333.1 - 1.2e-15 56.6 5.2 2.8e-15 55.4 5.2 1.7 1 0 0 1 1 1 1 Hypoxia-inducible factor-1 PAS_9 PF13426.7 EMC86333.1 - 7.4e-10 39.0 0.0 0.00026 21.2 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 EMC86333.1 - 2.5e-08 34.2 0.0 0.0011 19.2 0.0 2.4 2 0 0 2 2 2 2 PAS fold HLH PF00010.26 EMC86333.1 - 0.0099 15.8 0.4 0.0099 15.8 0.4 2.4 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain SNAPc_SNAP43 PF09808.9 EMC86334.1 - 2.1e-45 155.0 4.6 2.1e-45 155.0 4.6 1.6 2 0 0 2 2 2 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 DUF4539 PF15072.6 EMC86334.1 - 0.12 12.5 0.0 8.3 6.5 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4539) C2 PF00168.30 EMC86335.1 - 1.1e-18 67.4 0.0 1.2e-09 38.3 0.0 2.5 2 0 0 2 2 2 2 C2 domain PBECR5 PF18814.1 EMC86335.1 - 0.1 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease5 UPF0730 PF15827.5 EMC86336.1 - 1.3e-25 88.8 5.9 2.6e-25 87.9 5.9 1.5 1 0 0 1 1 1 1 UPF0730 unknown protein family SERTA PF06031.13 EMC86336.1 - 3e-14 52.4 2.4 4.5e-14 51.8 2.4 1.3 1 0 0 1 1 1 1 SERTA motif Ras PF00071.22 EMC86337.1 - 9.8e-49 165.1 0.0 1.2e-48 164.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC86337.1 - 1.4e-18 67.2 0.0 2.1e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC86337.1 - 2.3e-05 23.9 0.0 3.2e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family TniB PF05621.11 EMC86337.1 - 0.086 12.2 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein Cys_knot PF00007.22 EMC86339.1 - 5.2e-13 49.2 4.5 5.2e-13 49.2 4.5 1.0 1 0 0 1 1 1 1 Cystine-knot domain B56 PF01603.20 EMC86340.1 - 1.4e-193 643.5 12.3 1.8e-193 643.2 12.3 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 EMC86340.1 - 0.051 13.5 6.5 0.96 9.3 0.5 3.4 3 1 0 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal SBF2 PF12335.8 EMC86340.1 - 0.09 12.4 0.2 0.26 10.9 0.0 1.8 2 0 0 2 2 2 0 Myotubularin protein NAD1 PF18778.1 EMC86340.1 - 0.11 12.6 1.2 0.3 11.2 0.4 2.0 2 0 0 2 2 2 0 Novel AID APOBEC clade 1 HAD_2 PF13419.6 EMC86340.1 - 0.23 11.5 1.6 1.1 9.3 0.1 2.6 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase WD40 PF00400.32 EMC86342.1 - 6.9e-14 52.0 10.8 0.0076 17.1 0.1 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC86342.1 - 3.1e-08 33.8 0.1 2.9 8.2 0.0 5.0 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 EMC86342.1 - 0.0076 14.6 0.0 2.4 6.4 0.0 2.1 2 0 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz BetR PF08667.10 EMC86342.1 - 0.079 13.0 0.2 0.63 10.1 0.0 2.4 2 1 0 2 2 2 0 BetR domain PAP2 PF01569.21 EMC86343.1 - 2.7e-15 56.3 7.7 7e-15 55.0 7.7 1.7 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 EMC86343.1 - 2.5e-06 27.3 4.4 2.5e-06 27.3 4.4 2.1 1 1 1 2 2 2 1 PAP2 superfamily FTHFS PF01268.19 EMC86344.1 - 5.5e-260 863.3 0.0 7.3e-260 862.9 0.0 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 EMC86344.1 - 3.8e-67 224.6 1.0 3.8e-67 224.6 1.0 1.9 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 EMC86344.1 - 2.8e-32 111.4 0.1 1.9e-31 108.7 0.2 2.3 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain BTB PF00651.31 EMC86346.1 - 7.7e-20 71.2 1.6 7.7e-20 71.2 1.6 1.9 2 0 0 2 2 2 1 BTB/POZ domain zf-C2H2_4 PF13894.6 EMC86346.1 - 4e-11 42.8 60.8 0.14 13.0 0.1 10.3 9 0 0 9 9 9 6 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC86346.1 - 3.6e-08 33.4 64.1 0.036 14.5 0.1 10.4 10 0 0 10 10 10 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC86346.1 - 0.00071 19.9 2.6 0.00071 19.9 2.6 8.7 9 1 0 9 9 8 3 Zinc-finger double domain zf_UBZ PF18439.1 EMC86346.1 - 0.007 15.9 39.6 0.094 12.3 0.1 8.8 8 1 1 9 9 9 3 Ubiquitin-Binding Zinc Finger zf-met PF12874.7 EMC86346.1 - 0.017 15.5 42.9 0.047 14.1 0.4 9.3 8 1 0 8 8 8 0 Zinc-finger of C2H2 type CpXC PF14353.6 EMC86346.1 - 0.019 15.0 21.9 3.1 7.9 3.0 5.8 3 1 2 5 5 5 0 CpXC protein zf-C2H2_jaz PF12171.8 EMC86346.1 - 0.027 14.8 0.2 0.027 14.8 0.2 8.4 9 0 0 9 9 9 0 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 EMC86346.1 - 0.063 13.6 24.2 0.89 9.9 0.1 4.9 3 1 1 4 4 4 0 C2H2-type zinc ribbon zf-Di19 PF05605.12 EMC86346.1 - 0.38 11.1 44.2 0.078 13.3 3.1 7.7 3 2 5 8 8 8 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_9 PF16293.5 EMC86346.1 - 3.9 7.4 11.7 8.2 6.4 0.1 5.1 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) HSP70 PF00012.20 EMC86347.1 - 1.3e-263 875.6 11.4 1.5e-263 875.5 11.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EMC86347.1 - 2.4e-17 62.7 0.7 9.3e-16 57.5 0.1 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EMC86347.1 - 0.00063 19.5 0.0 0.0017 18.1 0.0 1.8 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 EMC86347.1 - 0.00072 19.9 3.2 1.5 9.3 0.0 3.6 3 1 0 3 3 3 2 Cell division protein FtsA CRIC_ras_sig PF10534.9 EMC86347.1 - 0.0026 17.9 0.0 0.0085 16.2 0.0 1.9 1 1 0 1 1 1 1 Connector enhancer of kinase suppressor of ras Hydantoinase_A PF01968.18 EMC86347.1 - 0.019 14.2 1.0 0.06 12.6 0.2 2.2 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase SHS2_FTSA PF02491.20 EMC86347.1 - 0.26 11.7 1.7 8.8 6.8 0.4 2.7 2 0 0 2 2 2 0 SHS2 domain inserted in FTSA PPPI_inhib PF14895.6 EMC86348.1 - 6.4e-37 127.5 0.0 7.5e-37 127.3 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 1 inhibitor TFIIB PF00382.19 EMC86349.1 - 1.8e-32 111.2 0.0 5.9e-16 58.3 0.0 2.7 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 EMC86349.1 - 4.9e-27 94.2 11.0 4.9e-27 94.2 11.0 2.6 3 0 0 3 3 3 1 Brf1-like TBP-binding domain Cyclin_N PF00134.23 EMC86349.1 - 1e-07 31.8 0.2 0.0006 19.6 0.0 2.6 2 0 0 2 2 2 2 Cyclin, N-terminal domain RB_B PF01857.20 EMC86349.1 - 0.0017 18.4 0.2 0.0047 17.0 0.2 1.7 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain TFIIB_C_1 PF18542.1 EMC86349.1 - 0.05 13.6 0.0 0.23 11.5 0.0 2.1 2 0 0 2 2 2 0 Transcription factor IIB C-terminal module 1 SNAD2 PF18745.1 EMC86349.1 - 0.13 11.9 1.9 0.25 11.0 1.9 1.4 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 2 PHR PF08005.12 EMC86350.1 - 1.5e-44 152.3 1.3 2.6e-44 151.5 1.3 1.4 1 0 0 1 1 1 1 PHR domain BTB PF00651.31 EMC86350.1 - 1.1e-24 86.8 0.1 1.4e-23 83.2 0.0 2.3 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 EMC86350.1 - 8.4e-08 32.3 3.1 1.3e-07 31.7 1.1 2.3 2 1 0 2 2 2 1 BTB And C-terminal Kelch DUF4082 PF13313.6 EMC86350.1 - 0.0019 18.3 0.1 0.0036 17.4 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4082) NUDIX PF00293.28 EMC86351.1 - 0.00063 19.8 0.1 0.0039 17.2 0.1 1.9 1 1 0 1 1 1 1 NUDIX domain ESPR PF13018.6 EMC86351.1 - 0.057 13.2 0.3 0.14 12.0 0.3 1.7 1 0 0 1 1 1 0 Extended Signal Peptide of Type V secretion system EGF PF00008.27 EMC86352.1 - 3.3e-78 257.5 281.8 5.1e-09 36.3 6.5 18.7 20 0 0 20 20 20 15 EGF-like domain hEGF PF12661.7 EMC86352.1 - 1.6e-44 149.0 246.9 7.7e-06 26.3 7.5 20.4 22 0 0 22 22 22 14 Human growth factor-like EGF MNNL PF07657.13 EMC86352.1 - 2.5e-27 94.7 2.0 2.5e-27 94.7 2.0 6.4 8 2 0 8 8 8 1 N terminus of Notch ligand DSL PF01414.19 EMC86352.1 - 2.3e-24 85.4 5.9 2.3e-24 85.4 5.9 13.9 11 3 3 14 14 14 3 Delta serrate ligand EGF_2 PF07974.13 EMC86352.1 - 2.4e-18 66.2 320.0 0.00034 20.9 6.6 20.2 20 0 0 20 20 20 13 EGF-like domain EGF_CA PF07645.15 EMC86352.1 - 3.5e-05 23.9 24.4 0.00037 20.6 10.2 19.9 9 4 11 20 20 20 9 Calcium-binding EGF domain 7tm_1 PF00001.21 EMC86353.1 - 7.5e-38 130.4 23.7 1.1e-37 129.8 23.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.13 EMC86353.1 - 7.8e-05 21.9 6.1 7.8e-05 21.9 6.1 2.4 2 1 0 2 2 2 1 Taste receptor protein (TAS2R) COX7C PF02935.16 EMC86353.1 - 0.019 15.2 7.5 0.065 13.5 0.7 4.1 5 0 0 5 5 5 0 Cytochrome c oxidase subunit VIIc DUF2909 PF11137.8 EMC86353.1 - 0.048 13.6 0.0 0.048 13.6 0.0 3.6 4 1 1 5 5 5 0 Protein of unknown function (DUF2909) Herpes_US9 PF06072.11 EMC86353.1 - 5.9 6.8 7.7 6.8 6.6 0.4 3.6 3 0 0 3 3 3 0 Alphaherpesvirus tegument protein US9 SERTA PF06031.13 EMC86354.1 - 5.6e-18 64.3 2.2 1.2e-17 63.2 2.2 1.6 1 0 0 1 1 1 1 SERTA motif DUF4279 PF14106.6 EMC86354.1 - 0.048 13.9 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4279) GET2 PF08690.10 EMC86354.1 - 0.13 11.9 6.0 0.18 11.4 6.0 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 Clathrin_bdg PF15045.6 EMC86355.1 - 3.9e-31 106.9 0.8 1.2e-30 105.3 0.9 1.9 2 0 0 2 2 2 1 Clathrin-binding box of Aftiphilin, vesicle trafficking FEZ PF07763.13 EMC86355.1 - 0.0034 17.2 0.4 0.0054 16.5 0.4 1.3 1 0 0 1 1 1 1 FEZ-like protein Gln-synt_N PF03951.19 EMC86355.1 - 0.02 14.6 0.2 0.07 12.9 0.1 2.0 2 0 0 2 2 2 0 Glutamine synthetase, beta-Grasp domain PDZ PF00595.24 EMC86356.1 - 3.7e-05 24.0 0.0 7.2e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Collagen PF01391.18 EMC86358.1 - 1.4e-06 28.0 22.5 5.4e-06 26.1 22.5 1.8 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) Rhomboid PF01694.22 EMC86359.1 - 4.2e-18 65.8 7.2 6.9e-18 65.1 7.2 1.3 1 0 0 1 1 1 1 Rhomboid family COPI_assoc PF08507.10 EMC86359.1 - 6.4 6.8 9.9 0.16 12.0 1.0 2.6 3 0 0 3 3 3 0 COPI associated protein YiaAB PF05360.14 EMC86359.1 - 6.9 7.0 9.2 1.5 9.1 1.8 3.2 3 0 0 3 3 3 0 yiaA/B two helix domain C4 PF01413.19 EMC86360.1 - 7.2e-80 264.6 3.7 1.4e-41 141.3 0.2 2.1 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen Collagen PF01391.18 EMC86360.1 - 8.4e-74 243.3 294.6 5.1e-10 39.0 24.1 12.9 2 2 10 12 12 12 11 Collagen triple helix repeat (20 copies) Miff PF05644.11 EMC86361.1 - 5e-140 466.2 1.3 5.6e-140 466.0 1.3 1.0 1 0 0 1 1 1 1 Mitochondrial and peroxisomal fission factor Mff dsrm PF00035.26 EMC86362.1 - 0.012 16.3 0.0 0.031 15.0 0.0 1.7 2 0 0 2 2 2 0 Double-stranded RNA binding motif ArfGap PF01412.18 EMC86363.1 - 1.2e-10 41.5 0.0 2.5e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Folate_carrier PF01770.18 EMC86364.1 - 3.9e-176 585.8 13.8 4.7e-176 585.6 13.8 1.0 1 0 0 1 1 1 1 Reduced folate carrier MFS_1 PF07690.16 EMC86364.1 - 1.9e-10 40.2 17.6 1.9e-10 40.2 17.6 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Herpes_pp38 PF04846.13 EMC86364.1 - 7.2 6.6 6.2 1.1 9.3 0.2 2.8 3 0 0 3 3 3 0 Herpesvirus pp38 phosphoprotein Folate_carrier PF01770.18 EMC86365.1 - 1.4e-175 583.9 19.4 1.7e-175 583.7 19.4 1.0 1 0 0 1 1 1 1 Reduced folate carrier MFS_1 PF07690.16 EMC86365.1 - 6.4e-11 41.8 18.6 6.4e-11 41.8 18.6 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily IL8 PF00048.20 EMC86366.1 - 1.9e-18 66.4 0.1 3.3e-18 65.6 0.1 1.4 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like WD40 PF00400.32 EMC86367.1 - 6e-65 213.6 22.7 1.8e-08 34.9 0.4 8.2 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC86367.1 - 1.1e-20 73.7 3.1 0.022 15.0 0.0 7.3 1 1 7 8 8 8 7 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EMC86367.1 - 6.9e-12 45.3 4.2 0.022 14.1 0.1 5.0 2 1 2 4 4 4 4 WD40-like domain Nup160 PF11715.8 EMC86367.1 - 3.9e-05 22.5 6.0 0.2 10.3 0.0 5.9 2 2 5 7 7 7 1 Nucleoporin Nup120/160 WD40_3 PF15911.5 EMC86367.1 - 0.019 15.0 0.0 15 5.7 0.0 3.4 3 0 0 3 3 3 0 WD domain, G-beta repeat Frtz PF11768.8 EMC86367.1 - 0.027 12.8 0.1 0.17 10.2 0.0 2.3 1 1 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF5046 PF16465.5 EMC86367.1 - 0.027 13.9 0.1 0.74 9.2 0.0 2.9 2 1 0 3 3 3 0 Domain of unknown function (DUF5046) ZirS_C PF16583.5 EMC86367.1 - 0.056 13.0 0.0 8.9 5.9 0.0 3.3 3 1 1 4 4 4 0 Zinc-regulated secreted antivirulence protein C-terminal domain Invasin_D3 PF09134.10 EMC86367.1 - 0.08 13.3 0.3 21 5.5 0.0 2.8 2 0 0 2 2 2 0 Invasin, domain 3 PID_2 PF14719.6 EMC86368.1 - 9.2e-19 68.0 0.5 1.4e-18 67.4 0.5 1.3 1 1 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PID PF00640.23 EMC86368.1 - 5.7e-07 29.7 0.2 8.1e-07 29.2 0.2 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) EGF PF00008.27 EMC86369.1 - 3.8e-55 183.7 125.0 2.5e-09 37.2 10.9 9.5 9 0 0 9 9 9 9 EGF-like domain hEGF PF12661.7 EMC86369.1 - 1.8e-33 114.0 102.0 2.5e-06 27.9 2.5 10.5 9 1 0 9 9 9 9 Human growth factor-like EGF EGF_2 PF07974.13 EMC86369.1 - 5.5e-16 58.6 144.3 0.00085 19.6 6.4 9.7 9 0 0 9 9 9 8 EGF-like domain EGF_CA PF07645.15 EMC86369.1 - 3.1e-07 30.5 128.5 2.1e-05 24.6 7.7 9.7 3 1 6 9 9 9 6 Calcium-binding EGF domain EGF_3 PF12947.7 EMC86369.1 - 0.0019 18.3 127.0 0.0069 16.6 8.6 9.6 8 1 1 9 9 9 6 EGF domain FXa_inhibition PF14670.6 EMC86369.1 - 0.0051 17.1 9.0 0.0051 17.1 9.0 9.6 4 2 5 9 9 9 3 Coagulation Factor Xa inhibitory site cEGF PF12662.7 EMC86369.1 - 2.2 8.3 89.9 0.067 13.1 0.9 10.3 9 1 0 9 9 9 0 Complement Clr-like EGF-like Laminin_EGF PF00053.24 EMC86369.1 - 3.9 7.7 118.9 4.2 7.6 3.3 9.5 2 1 7 9 9 9 0 Laminin EGF domain HECT PF00632.25 EMC86370.1 - 1.6e-87 293.9 0.7 4.9e-87 292.3 0.0 2.1 3 0 0 3 3 3 1 HECT-domain (ubiquitin-transferase) WWE PF02825.20 EMC86370.1 - 0.00031 21.3 0.7 0.0012 19.3 0.7 2.0 1 1 0 1 1 1 1 WWE domain HEAT_2 PF13646.6 EMC86370.1 - 0.067 13.6 0.1 0.98 9.9 0.0 3.1 3 1 1 4 4 4 0 HEAT repeats F-box PF00646.33 EMC86371.1 - 8.3e-11 41.5 2.8 9.4e-11 41.3 0.9 2.1 2 1 0 2 2 2 1 F-box domain F-box-like PF12937.7 EMC86371.1 - 2.2e-10 40.3 0.1 4.2e-10 39.3 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EMC86371.1 - 1.1e-06 28.5 0.1 1.6e-06 27.9 0.1 1.4 1 0 0 1 1 1 1 F-box PRANC PF09372.10 EMC86371.1 - 0.019 15.3 0.6 0.23 11.8 0.0 2.2 1 1 1 2 2 2 0 PRANC domain MFS_1 PF07690.16 EMC86372.1 - 4.2e-49 167.4 22.2 8.5e-39 133.5 20.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily CbtA PF09490.10 EMC86372.1 - 0.078 12.7 6.4 0.92 9.2 5.4 2.9 2 1 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) zf-H2C2_2 PF13465.6 EMC86373.1 - 1.2e-23 82.4 81.0 1.2e-05 25.5 0.5 11.6 12 0 0 12 12 12 7 Zinc-finger double domain BTB PF00651.31 EMC86373.1 - 1.8e-21 76.4 0.1 4.4e-21 75.2 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.26 EMC86373.1 - 9.8e-17 60.4 79.2 0.00022 21.5 3.3 11.0 10 0 0 10 10 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC86373.1 - 3.3e-14 52.4 86.8 0.04 14.8 0.6 11.9 11 0 0 11 11 11 10 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC86373.1 - 1.7e-07 31.3 47.7 0.00016 21.9 0.1 9.9 10 0 0 10 10 10 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC86373.1 - 1.2e-05 25.6 0.3 1.2e-05 25.6 0.3 8.8 9 0 0 9 9 9 3 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EMC86373.1 - 1.4e-05 24.9 62.9 0.047 13.7 1.8 9.8 9 0 0 9 9 9 7 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EMC86373.1 - 0.012 15.4 0.3 0.012 15.4 0.3 5.9 6 0 0 6 6 6 0 zinc-finger C2H2-type zf-C2HC_2 PF13913.6 EMC86373.1 - 6.4 6.8 33.0 0.94 9.5 0.3 8.0 7 0 0 7 7 7 0 zinc-finger of a C2HC-type C2 PF00168.30 EMC86374.1 - 8.2e-32 109.6 3.5 1.2e-14 54.4 0.0 3.5 2 1 0 2 2 2 2 C2 domain RasGAP PF00616.19 EMC86374.1 - 3.5e-27 95.5 0.3 1.2e-16 61.1 0.0 3.1 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase PH PF00169.29 EMC86374.1 - 3.8e-17 62.7 0.6 3.8e-17 62.7 0.6 3.0 4 0 0 4 4 4 1 PH domain BTK PF00779.19 EMC86374.1 - 9.4e-13 47.7 2.2 2e-12 46.7 2.2 1.6 1 0 0 1 1 1 1 BTK motif CEP76-C2 PF15627.6 EMC86374.1 - 0.00015 21.3 0.4 0.3 10.7 0.0 2.8 3 0 0 3 3 3 2 CEP76 C2 domain PH_8 PF15409.6 EMC86374.1 - 0.0011 19.1 0.1 0.0042 17.3 0.1 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain DNA_pol3_beta_2 PF02767.16 EMC86374.1 - 0.092 13.0 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase III beta subunit, central domain zf-rbx1 PF12678.7 EMC86375.1 - 3.8e-16 59.1 16.5 4.5e-16 58.9 16.5 1.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EMC86375.1 - 1.6e-08 34.5 10.9 1.7e-08 34.4 10.9 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EMC86375.1 - 3e-08 33.9 13.1 4.2e-08 33.4 13.1 1.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC86375.1 - 6.4e-05 22.7 12.1 0.00011 21.9 12.1 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMC86375.1 - 0.0011 18.8 10.2 0.0017 18.1 10.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC86375.1 - 0.0017 18.2 13.6 0.0034 17.2 13.6 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.6 EMC86375.1 - 0.0076 16.2 9.6 0.05 13.5 5.2 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 zf-RING_5 PF14634.6 EMC86375.1 - 0.046 13.7 13.9 0.04 13.9 12.9 1.4 1 1 0 1 1 1 0 zinc-RING finger domain PHD PF00628.29 EMC86375.1 - 0.75 9.7 14.5 1.7 8.6 14.5 1.6 1 1 0 1 1 1 0 PHD-finger Prok-RING_4 PF14447.6 EMC86375.1 - 0.83 9.6 14.8 0.78 9.7 13.5 1.6 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 EMC86375.1 - 1.6 8.6 13.2 0.59 10.0 11.0 1.4 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 EMC86375.1 - 3 7.7 11.0 0.54 10.1 7.3 1.8 2 0 0 2 2 2 0 RING-like zinc finger zf-C3H2C3 PF17122.5 EMC86375.1 - 7 6.8 12.8 9.4 6.4 11.9 1.9 1 1 0 1 1 1 0 Zinc-finger Pkinase PF00069.25 EMC86376.1 - 3.7e-60 203.5 0.3 5.1e-60 203.1 0.3 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC86376.1 - 4.5e-34 117.9 0.9 9.2e-34 116.9 0.3 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase RGS PF00615.19 EMC86376.1 - 1.1e-13 51.5 3.6 1.7e-13 50.9 1.6 2.1 2 0 0 2 2 2 1 Regulator of G protein signaling domain Pkinase_fungal PF17667.1 EMC86376.1 - 1.6e-05 23.9 0.0 2.5e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EMC86376.1 - 5.3e-05 22.7 0.0 7.5e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like DUF469 PF04320.14 EMC86376.1 - 0.11 13.4 0.2 0.36 11.7 0.1 1.9 2 0 0 2 2 2 0 Protein with unknown function (DUF469) Na_K-ATPase PF00287.18 EMC86377.1 - 1.3e-89 300.2 0.1 1.4e-89 300.0 0.1 1.0 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain CdiI_2 PF18593.1 EMC86377.1 - 0.11 13.2 0.0 0.19 12.4 0.0 1.4 1 0 0 1 1 1 0 CdiI immunity protein DP PF08781.10 EMC86378.1 - 1.8e-61 206.1 3.2 3.5e-61 205.1 3.2 1.5 1 0 0 1 1 1 1 Transcription factor DP E2F_TDP PF02319.20 EMC86378.1 - 1.2e-26 92.6 0.1 2.7e-26 91.4 0.1 1.6 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain FGGY_N PF00370.21 EMC86379.1 - 8.9e-38 130.2 0.0 3.3e-36 125.1 0.0 2.5 2 1 0 2 2 2 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 EMC86379.1 - 6e-31 107.7 0.0 1.1e-30 106.9 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain XRN_M PF17846.1 EMC86380.1 - 1.9e-97 327.0 6.4 5e-97 325.6 6.4 1.7 1 0 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 EMC86380.1 - 4.4e-86 288.2 0.0 1.1e-85 287.0 0.0 1.7 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN1_D1 PF18332.1 EMC86380.1 - 5.9e-33 114.3 2.8 1.6e-32 112.9 2.8 1.7 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D1 domain SH3_12 PF18129.1 EMC86380.1 - 2.4e-21 75.6 0.0 7.2e-21 74.1 0.0 1.9 2 0 0 2 2 2 1 Xrn1 SH3-like domain XRN1_D2_D3 PF18334.1 EMC86380.1 - 5e-07 29.9 0.0 2.7e-06 27.5 0.0 2.4 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D2/D3 domain PI3_PI4_kinase PF00454.27 EMC86381.1 - 8e-59 199.5 0.1 1.5e-58 198.5 0.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 EMC86381.1 - 6.4e-40 137.4 9.5 1.2e-39 136.6 4.5 3.2 2 1 0 2 2 2 1 FAT domain UME PF08064.13 EMC86381.1 - 9.2e-20 70.5 5.5 1e-19 70.3 0.2 3.7 3 0 0 3 3 3 1 UME (NUC010) domain FATC PF02260.20 EMC86381.1 - 1.9e-12 46.8 0.0 4.8e-12 45.5 0.0 1.8 1 0 0 1 1 1 1 FATC domain HEAT PF02985.22 EMC86381.1 - 1.6e-08 34.1 2.3 0.91 10.0 0.0 7.6 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.6 EMC86381.1 - 0.045 14.3 0.3 19 5.9 0.0 4.5 4 0 0 4 4 4 0 HEAT-like repeat SgrT PF15894.5 EMC86381.1 - 0.31 11.0 2.8 0.46 10.5 0.1 2.5 2 0 0 2 2 2 0 Inhibitor of glucose uptake transporter SgrT CH PF00307.31 EMC86382.1 - 1.3e-89 295.6 2.6 2.1e-25 89.0 0.1 4.3 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_1 PF00036.32 EMC86382.1 - 1.1e-12 46.5 1.7 1.9e-05 23.9 0.1 3.2 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EMC86382.1 - 3.1e-10 40.3 0.1 1.2e-09 38.5 0.1 2.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EMC86382.1 - 5.4e-09 35.3 0.2 0.00035 20.3 0.0 3.1 2 0 0 2 2 2 2 EF-hand domain CAMSAP_CH PF11971.8 EMC86382.1 - 7.7e-06 25.7 0.1 0.00087 19.1 0.0 3.3 4 0 0 4 4 4 1 CAMSAP CH domain EF-hand_5 PF13202.6 EMC86382.1 - 1.1e-05 24.7 6.9 0.028 13.9 0.0 4.0 3 1 1 4 4 4 2 EF hand EF-hand_8 PF13833.6 EMC86382.1 - 2.4e-05 24.1 0.4 0.28 11.0 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain pair DUF5580 PF17743.1 EMC86382.1 - 0.01 14.4 0.0 0.017 13.7 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5580) TRP_2 PF08344.11 EMC86383.1 - 2.2e-25 88.6 2.0 5.3e-25 87.4 2.0 1.7 1 0 0 1 1 1 1 Transient receptor ion channel II Ion_trans PF00520.31 EMC86383.1 - 2.1e-16 59.9 14.0 4e-16 59.0 14.0 1.4 1 0 0 1 1 1 1 Ion transport protein Ank_2 PF12796.7 EMC86383.1 - 2.9e-05 24.6 3.5 0.001 19.6 0.2 3.1 3 1 1 4 4 4 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC86383.1 - 0.00011 22.6 0.1 1 10.1 0.0 3.0 2 1 0 2 2 2 2 Ankyrin repeats (many copies) DUF2407_C PF13373.6 EMC86383.1 - 0.045 13.9 0.1 0.26 11.4 0.0 2.4 3 0 0 3 3 3 0 DUF2407 C-terminal domain TALPID3 PF15324.6 EMC86383.1 - 0.27 8.9 3.0 0.11 10.2 0.4 1.5 2 0 0 2 2 2 0 Hedgehog signalling target CUB PF00431.20 EMC86384.1 - 9.4e-61 203.0 0.0 3.4e-30 104.6 0.0 2.2 2 0 0 2 2 2 2 CUB domain NTR PF01759.21 EMC86384.1 - 5.2e-16 58.4 0.7 1.2e-15 57.2 0.0 1.9 2 0 0 2 2 2 1 UNC-6/NTR/C345C module CUB_2 PF02408.20 EMC86384.1 - 4.7e-08 32.8 0.1 0.0024 17.7 0.0 2.7 2 0 0 2 2 2 2 CUB-like domain TIMP PF00965.17 EMC86384.1 - 0.004 17.0 1.1 0.0092 15.8 1.1 1.6 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase Surp PF01805.20 EMC86385.1 - 4.7e-19 68.1 0.2 1.3e-18 66.7 0.2 1.8 1 0 0 1 1 1 1 Surp module RRM_1 PF00076.22 EMC86385.1 - 2.5e-15 56.0 0.0 5.5e-15 54.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) cwf21 PF08312.12 EMC86385.1 - 6.5e-10 39.0 2.7 6.5e-10 39.0 2.7 3.4 4 0 0 4 4 4 1 cwf21 domain CTK3 PF12243.8 EMC86385.1 - 3.5e-05 23.8 0.4 9.8e-05 22.4 0.1 1.8 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 CTD_bind PF04818.13 EMC86385.1 - 0.00087 20.1 0.6 0.0041 17.9 0.2 2.5 2 0 0 2 2 2 1 RNA polymerase II-binding domain. SET_assoc PF11767.8 EMC86385.1 - 0.015 15.0 0.1 0.034 13.8 0.1 1.6 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated Sulfotransfer_1 PF00685.27 EMC86386.1 - 3.7e-13 49.6 0.0 4.3e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC86386.1 - 2.5e-05 24.8 0.0 7.1e-05 23.3 0.0 1.7 2 0 0 2 2 2 1 Sulfotransferase family GDYXXLXY PF14345.6 EMC86386.1 - 0.14 12.0 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 GDYXXLXY protein Na_H_Exchanger PF00999.21 EMC86387.1 - 3.8e-83 279.4 29.7 8e-83 278.3 29.7 1.5 1 1 0 1 1 1 1 Sodium/hydrogen exchanger family Scramblase PF03803.15 EMC86388.1 - 6.1e-95 316.7 0.0 7.3e-95 316.5 0.0 1.0 1 0 0 1 1 1 1 Scramblase Scramblase PF03803.15 EMC86389.1 - 3.1e-70 235.9 0.4 3.4e-70 235.8 0.4 1.0 1 0 0 1 1 1 1 Scramblase DUF4413 PF14372.6 EMC86389.1 - 0.11 12.9 0.0 0.17 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) DUF5440 PF17509.2 EMC86390.1 - 0.04 13.5 0.0 0.052 13.1 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5440) RVT_1 PF00078.27 EMC86390.1 - 0.054 13.0 0.0 0.082 12.4 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) zf_ZIC PF18366.1 EMC86391.1 - 5.7e-27 93.6 0.9 5.7e-27 93.6 0.9 3.6 4 0 0 4 4 4 1 Zic proteins zinc finger domain zf-C2H2 PF00096.26 EMC86391.1 - 6.3e-21 73.6 30.9 4.9e-06 26.7 0.2 5.6 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC86391.1 - 1.2e-17 63.5 33.1 7.3e-08 32.5 0.3 5.9 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC86391.1 - 6.5e-07 29.7 42.3 0.0061 17.3 0.2 5.9 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC86391.1 - 8.3e-05 22.8 12.7 0.21 11.9 0.1 5.0 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 EMC86391.1 - 0.00052 20.3 11.9 0.071 13.4 1.7 3.4 1 1 2 3 3 3 2 C2H2-type zinc ribbon zf-met PF12874.7 EMC86391.1 - 0.44 11.0 0.2 0.44 11.0 0.2 4.7 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_aberr PF17017.5 EMC86391.1 - 1.3 9.2 11.5 7.8 6.6 0.1 3.6 1 1 3 4 4 4 0 Aberrant zinc-finger FOXP-CC PF16159.5 EMC86391.1 - 9 7.0 16.5 16 6.2 0.0 5.0 2 2 3 5 5 5 0 FOXP coiled-coil domain zf_ZIC PF18366.1 EMC86392.1 - 6e-28 96.7 0.9 6e-28 96.7 0.9 3.7 4 0 0 4 4 4 1 Zic proteins zinc finger domain zf-C2H2 PF00096.26 EMC86392.1 - 2.3e-21 75.0 31.9 8.8e-06 25.9 0.2 5.8 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC86392.1 - 6.3e-20 70.6 29.6 1.3e-07 31.7 0.3 5.6 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC86392.1 - 6.6e-13 48.3 26.8 0.0079 17.0 2.5 6.0 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC86392.1 - 6.4e-06 26.3 14.3 0.12 12.7 0.2 4.9 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMC86392.1 - 4.3e-05 23.4 10.3 0.15 12.1 2.8 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 EMC86392.1 - 0.0013 19.0 14.0 0.003 17.9 1.2 4.5 4 0 0 4 4 4 1 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 EMC86392.1 - 0.0019 18.4 12.8 0.077 13.3 2.6 3.3 1 1 2 3 3 3 3 C2H2-type zinc ribbon PHD_Oberon PF07227.11 EMC86393.1 - 0.00028 20.8 1.8 0.00035 20.5 1.8 1.1 1 0 0 1 1 1 1 PHD - plant homeodomain finger protein 7tm_1 PF00001.21 EMC86394.1 - 1.4e-55 188.5 22.7 2e-55 187.9 22.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC86394.1 - 2.1e-09 37.1 25.2 3.1e-09 36.6 25.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Peptidase_M14 PF00246.24 EMC86395.1 - 1e-93 314.3 0.0 1.3e-93 314.0 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 EMC86395.1 - 3.4e-19 69.0 0.3 8e-19 67.8 0.3 1.7 1 0 0 1 1 1 1 Carboxypeptidase activation peptide 7tm_4 PF13853.6 EMC86396.1 - 3.2e-49 168.1 11.3 4e-49 167.8 11.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC86396.1 - 1.8e-29 102.9 15.4 2.7e-29 102.3 15.4 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC86396.1 - 0.00084 18.8 15.3 0.0013 18.2 15.3 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC86396.1 - 0.0012 18.5 8.1 0.0012 18.5 8.1 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx eIF3_N PF09440.10 EMC86397.1 - 2e-31 109.2 2.4 2e-31 109.2 2.4 2.0 3 0 0 3 3 3 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 EMC86397.1 - 2.4e-19 69.8 0.2 1e-18 67.8 0.0 2.2 3 0 0 3 3 3 1 PCI domain HD_assoc PF13286.6 EMC86397.1 - 0.05 14.1 1.4 2.2 8.9 0.2 2.6 2 0 0 2 2 2 0 Phosphohydrolase-associated domain CSN8_PSD8_EIF3K PF10075.9 EMC86397.1 - 0.14 12.2 1.0 0.69 9.9 0.0 2.6 4 0 0 4 4 4 0 CSN8/PSMD8/EIF3K family TPR_19 PF14559.6 EMC86398.1 - 1.7e-10 41.3 9.4 1.3e-05 25.7 1.8 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMC86398.1 - 2.4e-10 40.4 8.6 0.0063 17.2 0.4 5.3 1 1 4 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 EMC86398.1 - 5.7e-10 38.5 11.2 0.00017 21.4 0.5 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 EMC86398.1 - 5.8e-07 30.1 3.2 0.61 10.8 0.2 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 EMC86398.1 - 2.2e-06 27.2 5.7 0.15 11.9 0.2 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMC86398.1 - 9.6e-05 22.3 11.4 0.052 13.8 0.1 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMC86398.1 - 0.0051 16.8 1.7 5.4 7.3 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EMC86398.1 - 0.0051 17.4 7.0 6 7.7 0.1 4.9 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 EMC86398.1 - 0.011 15.8 2.1 0.72 10.0 0.0 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat NARP1 PF12569.8 EMC86398.1 - 0.015 14.2 10.3 0.008 15.1 5.2 2.4 1 1 2 3 3 3 0 NMDA receptor-regulated protein 1 Alkyl_sulf_dimr PF14863.6 EMC86398.1 - 0.019 15.4 8.9 0.23 11.9 0.4 3.1 1 1 1 3 3 3 0 Alkyl sulfatase dimerisation TPR_20 PF14561.6 EMC86398.1 - 0.037 14.4 1.9 0.53 10.6 0.1 2.9 1 1 1 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC86398.1 - 0.14 12.4 10.4 0.46 10.7 3.8 3.5 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 MyTH4 PF00784.17 EMC86398.1 - 0.18 12.3 1.4 29 5.2 0.1 3.2 2 1 0 3 3 3 0 MyTH4 domain Fis1_TPR_C PF14853.6 EMC86398.1 - 0.19 11.8 4.9 10 6.3 0.1 3.6 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.6 EMC86398.1 - 0.39 11.2 6.3 1.7 9.2 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Ribonuclease_T2 PF00445.18 EMC86398.1 - 1.4 9.1 4.5 3.2 7.9 4.5 1.7 1 1 0 1 1 1 0 Ribonuclease T2 family TPR_12 PF13424.6 EMC86398.1 - 4.3 7.7 13.4 3 8.2 1.6 3.9 3 1 0 4 4 3 0 Tetratricopeptide repeat Neurensin PF14927.6 EMC86399.1 - 1.5e-07 31.2 0.0 2.1e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Neurensin DUF5539 PF17693.1 EMC86399.1 - 1.2 8.8 5.6 0.13 11.9 0.5 1.8 1 1 0 1 1 1 0 Family of unknown function (DUF5539) 7tm_1 PF00001.21 EMC86400.1 - 4.6e-51 173.7 25.3 6.1e-51 173.3 25.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC86400.1 - 1.9e-10 40.6 24.3 3.5e-10 39.7 24.3 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC86400.1 - 8.7e-09 35.4 22.2 8.7e-09 35.4 22.2 2.3 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC86400.1 - 1.4e-05 25.0 19.3 2.6e-05 24.1 12.5 2.2 2 0 0 2 2 2 2 Olfactory receptor DUF3377 PF11857.8 EMC86400.1 - 2.1 8.4 8.6 8.2 6.4 0.6 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3377) CS PF04969.16 EMC86401.1 - 4.5e-19 69.2 1.6 1.1e-18 68.0 1.6 1.7 1 0 0 1 1 1 1 CS domain EnY2 PF10163.9 EMC86402.1 - 1.8e-35 121.2 0.6 2e-35 121.0 0.6 1.0 1 0 0 1 1 1 1 Transcription factor e(y)2 DUF2294 PF10057.9 EMC86402.1 - 0.066 13.3 0.3 0.66 10.1 0.1 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2294) DUF3395 PF11875.8 EMC86403.1 - 7.5 6.4 10.8 13 5.6 10.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3395) Syntaphilin PF15290.6 EMC86404.1 - 6e-122 407.2 16.8 1.2e-121 406.2 16.8 1.5 1 0 0 1 1 1 1 Golgi-localised syntaxin-1-binding clamp CALCOCO1 PF07888.11 EMC86404.1 - 0.00017 20.6 11.2 0.00026 20.0 11.2 1.2 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Fez1 PF06818.15 EMC86404.1 - 0.00068 20.1 13.3 0.0012 19.3 13.3 1.3 1 0 0 1 1 1 1 Fez1 FPP PF05911.11 EMC86404.1 - 0.0028 15.9 14.7 0.0041 15.4 14.7 1.2 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil Atg14 PF10186.9 EMC86404.1 - 0.0032 16.6 8.6 0.0054 15.9 8.6 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 ArAE_1_C PF11728.8 EMC86404.1 - 0.021 14.8 7.8 0.042 13.8 7.8 1.4 1 0 0 1 1 1 0 Putative aromatic acid exporter C-terminal domain DUF3584 PF12128.8 EMC86404.1 - 0.063 10.8 13.1 0.087 10.3 13.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ERM PF00769.19 EMC86404.1 - 0.087 12.6 16.7 0.13 12.0 16.7 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family FAM76 PF16046.5 EMC86404.1 - 0.097 12.0 16.0 0.1 11.9 1.4 2.2 1 1 1 2 2 2 0 FAM76 protein Exonuc_VII_L PF02601.15 EMC86404.1 - 0.11 12.1 5.5 0.17 11.5 5.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit UPF0242 PF06785.11 EMC86404.1 - 0.12 12.4 14.8 0.25 11.4 14.8 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Sec8_exocyst PF04048.14 EMC86404.1 - 0.23 11.3 10.0 0.47 10.3 0.2 2.4 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain Golgin_A5 PF09787.9 EMC86404.1 - 0.33 10.4 15.0 0.61 9.5 15.0 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF4407 PF14362.6 EMC86404.1 - 0.4 10.0 5.1 0.58 9.5 5.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CC2-LZ PF16516.5 EMC86404.1 - 0.5 10.8 17.3 0.32 11.4 3.6 2.4 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator HR1 PF02185.16 EMC86404.1 - 0.53 10.4 15.6 1 9.5 1.2 3.2 2 1 1 3 3 3 0 Hr1 repeat Sec2p PF06428.11 EMC86404.1 - 0.79 9.7 17.3 0.18 11.8 3.1 3.1 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p TPR_MLP1_2 PF07926.12 EMC86404.1 - 0.96 9.5 19.2 0.61 10.2 7.3 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein FapA PF03961.13 EMC86404.1 - 1.7 7.2 11.3 2.7 6.5 11.3 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A Spc7 PF08317.11 EMC86404.1 - 3.5 6.4 20.1 15 4.4 20.0 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein BST2 PF16716.5 EMC86404.1 - 3.5 8.3 15.8 0.81 10.3 10.0 2.7 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 DUF745 PF05335.13 EMC86404.1 - 5 6.8 11.1 10 5.8 11.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF745) HrpB7 PF09486.10 EMC86404.1 - 6.1 7.2 10.2 11 6.4 2.6 2.3 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) GrpE PF01025.19 EMC86404.1 - 6.5 6.4 13.1 13 5.4 13.1 1.5 1 0 0 1 1 1 0 GrpE PKcGMP_CC PF16808.5 EMC86404.1 - 6.6 6.7 19.3 0.17 11.8 5.1 3.7 3 1 1 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Ly49 PF08391.10 EMC86404.1 - 6.9 7.1 8.4 5.8 7.3 6.3 2.0 1 1 0 1 1 1 0 Ly49-like protein, N-terminal region Hydrophobin PF01185.18 EMC86405.1 - 0.008 16.8 0.2 0.011 16.4 0.2 1.3 1 0 0 1 1 1 1 Fungal hydrophobin Ion_trans PF00520.31 EMC86406.1 - 3.5e-43 147.6 8.6 5e-43 147.1 8.6 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 EMC86406.1 - 2.1e-23 82.5 0.0 4.8e-23 81.3 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 EMC86406.1 - 1.4e-12 47.4 6.2 1.4e-12 47.4 6.2 2.1 2 0 0 2 2 2 1 Ion channel BTB_3 PF16017.5 EMC86406.1 - 1.5e-05 25.0 0.0 4.5e-05 23.5 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain PKD_channel PF08016.12 EMC86406.1 - 0.015 14.0 2.0 0.087 11.5 0.0 2.1 1 1 1 2 2 2 0 Polycystin cation channel Yae1_N PF09811.9 EMC86407.1 - 5.3e-35 118.8 151.1 1.8e+04 -116.0 151.1 12.7 1 1 0 1 1 1 0 Essential protein Yae1, N terminal DUF3915 PF13054.6 EMC86408.1 - 0.12 12.4 4.7 0.19 11.7 4.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.15 EMC86408.1 - 0.33 9.2 10.2 0.42 8.8 10.2 1.0 1 0 0 1 1 1 0 Atrophin-1 family CUB PF00431.20 EMC86410.1 - 0 1079.9 0.0 4.1e-25 88.3 0.0 14.3 14 0 0 14 14 14 14 CUB domain Sushi PF00084.20 EMC86410.1 - 6e-239 772.9 165.7 9e-11 42.2 0.3 28.5 28 0 0 28 28 28 28 Sushi repeat (SCR repeat) CUB_2 PF02408.20 EMC86410.1 - 1.9e-22 79.3 14.0 0.029 14.1 0.3 12.3 13 0 0 13 13 13 7 CUB-like domain HRM PF02793.22 EMC86410.1 - 0.0045 17.3 71.4 0.62 10.4 0.5 15.2 15 1 1 16 16 16 6 Hormone receptor domain zf-H2C2_5 PF13909.6 EMC86411.1 - 0.005 16.6 2.3 0.005 16.6 2.3 8.2 8 1 0 8 8 8 5 C2H2-type zinc-finger domain zf_C2H2_ZHX PF18387.1 EMC86411.1 - 0.015 14.9 38.8 0.19 11.4 1.0 6.7 6 2 1 7 7 7 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF2024 PF09630.10 EMC86411.1 - 0.33 10.9 0.0 0.33 10.9 0.0 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF2024) DUF5472 PF17566.2 EMC86411.1 - 0.54 10.3 3.6 28 4.8 0.1 4.2 4 1 1 5 5 5 0 Family of unknown function (DUF5472) Actin_micro PF17003.5 EMC86411.1 - 9.9 5.2 29.3 3.4 6.7 0.2 5.4 5 1 0 5 5 5 0 Putative actin-like family Fcf1 PF04900.12 EMC86412.1 - 1.7e-27 95.7 0.1 4e-27 94.5 0.0 1.7 2 0 0 2 2 2 1 Fcf1 PIN_9 PF18477.1 EMC86412.1 - 0.055 13.8 0.0 0.29 11.5 0.0 2.2 2 1 0 2 2 2 0 PIN like domain Di19_C PF14571.6 EMC86412.1 - 2.7 8.6 5.9 2.5 8.7 0.1 2.3 2 0 0 2 2 2 0 Stress-induced protein Di19, C-terminal Rad21_Rec8_N PF04825.13 EMC86413.1 - 1.7e-40 137.6 0.0 3.4e-40 136.6 0.0 1.6 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EMC86413.1 - 7.6e-23 79.6 0.2 3.6e-22 77.4 0.1 2.2 2 0 0 2 2 2 1 Conserved region of Rad21 / Rec8 like protein SMC_ScpA PF02616.14 EMC86413.1 - 0.0014 18.6 0.1 0.0014 18.6 0.1 1.9 2 0 0 2 2 2 1 Segregation and condensation protein ScpA SUIM_assoc PF16619.5 EMC86413.1 - 0.0054 16.8 3.5 0.041 14.0 3.5 2.5 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Cation_efflux PF01545.21 EMC86414.1 - 1.9e-41 142.0 18.3 2.6e-41 141.6 18.3 1.2 1 0 0 1 1 1 1 Cation efflux family Med30 PF11315.8 EMC86415.1 - 1.5e-65 219.9 1.6 1.7e-65 219.7 1.6 1.0 1 0 0 1 1 1 1 Mediator complex subunit 30 MetOD2 PF18548.1 EMC86415.1 - 0.061 13.4 1.5 0.14 12.2 1.5 1.6 1 0 0 1 1 1 0 Metanogen output domain 2 UPF0449 PF15136.6 EMC86415.1 - 0.092 13.2 3.9 0.21 12.0 3.9 1.9 1 1 0 1 1 1 0 Uncharacterised protein family UPF0449 NYD-SP28_assoc PF14775.6 EMC86415.1 - 0.27 11.4 4.7 0.56 10.3 4.7 1.5 1 0 0 1 1 1 0 Sperm tail C-terminal domain Glyco_transf_64 PF09258.10 EMC86416.1 - 4e-83 278.5 7.7 2.8e-62 210.2 1.1 3.2 3 0 0 3 3 3 3 Glycosyl transferase family 64 domain Exostosin PF03016.15 EMC86416.1 - 9.5e-25 87.4 0.6 1.5e-24 86.7 0.0 1.6 2 0 0 2 2 2 1 Exostosin family DNA_pol_E_B PF04042.16 EMC86416.1 - 0.06 12.7 0.1 3.4 7.0 0.0 2.7 3 0 0 3 3 3 0 DNA polymerase alpha/epsilon subunit B SAM_2 PF07647.17 EMC86417.1 - 1.7e-17 63.2 0.9 2.5e-17 62.7 0.9 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EMC86417.1 - 2.3e-11 44.0 0.9 3.3e-11 43.4 0.9 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 EMC86417.1 - 1.3e-08 34.7 0.1 2e-08 34.1 0.1 1.3 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain DUF5494 PF17598.2 EMC86417.1 - 0.11 12.6 0.1 3.5 7.8 0.0 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5494) TNFR_c6 PF00020.18 EMC86418.1 - 4.5e-27 94.2 36.2 1.3e-10 41.5 12.8 4.6 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region Death PF00531.22 EMC86418.1 - 9.6e-17 60.9 2.6 4.2e-09 36.4 0.0 2.4 1 1 1 2 2 2 2 Death domain BCDHK_Adom3 PF10436.9 EMC86418.1 - 0.054 13.3 1.1 0.3 10.9 1.1 2.0 1 1 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase POTRA_2 PF08479.11 EMC86418.1 - 0.11 12.4 0.0 4 7.3 0.0 2.3 2 0 0 2 2 2 0 POTRA domain, ShlB-type Lectin_C PF00059.21 EMC86419.1 - 3.5e-19 69.5 0.0 5.3e-19 69.0 0.0 1.3 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.18 EMC86419.1 - 8e-12 44.7 57.1 9.1e-08 31.8 23.4 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) MARVEL PF01284.23 EMC86420.1 - 1.4e-12 47.9 19.0 1.6e-12 47.6 19.0 1.1 1 0 0 1 1 1 1 Membrane-associating domain ABC2_membrane_5 PF13346.6 EMC86420.1 - 0.12 11.9 9.2 0.17 11.4 9.2 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF3687 PF12459.8 EMC86420.1 - 0.59 9.7 6.2 0.15 11.6 2.0 2.1 1 1 1 2 2 2 0 D-Ala-teichoic acid biosynthesis protein Cys_knot PF00007.22 EMC86422.1 - 1.8e-15 57.1 12.9 1.8e-15 57.1 12.9 2.8 3 0 0 3 3 3 1 Cystine-knot domain VWC PF00093.18 EMC86422.1 - 6.9e-12 45.5 8.9 6.9e-12 45.5 8.9 4.2 2 1 0 2 2 2 1 von Willebrand factor type C domain TSP_1 PF00090.19 EMC86422.1 - 0.00013 22.1 9.1 0.00013 22.1 9.1 2.6 3 0 0 3 3 3 1 Thrombospondin type 1 domain Phosphodiest PF01663.22 EMC86423.1 - 8.7e-77 259.1 0.0 1.8e-74 251.5 0.0 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Somatomedin_B PF01033.17 EMC86423.1 - 1.3e-15 57.5 46.1 1.1e-08 35.3 13.8 3.2 3 0 0 3 3 3 2 Somatomedin B domain Endonuclease_NS PF01223.23 EMC86423.1 - 3.5e-10 40.1 0.0 7.2e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Sulfatase PF00884.23 EMC86423.1 - 6.6e-05 22.4 0.0 0.02 14.3 0.0 2.2 2 0 0 2 2 2 2 Sulfatase Dcc1 PF09724.9 EMC86424.1 - 1.5e-89 300.6 2.5 1.8e-89 300.4 2.5 1.0 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 RepA_N PF06970.11 EMC86424.1 - 0.039 13.9 0.2 3.1 7.8 0.0 3.1 3 0 0 3 3 3 0 Replication initiator protein A (RepA) N-terminus DEP PF00610.21 EMC86425.1 - 8.2e-48 160.4 2.1 7.2e-26 90.1 0.3 2.3 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDZ_6 PF17820.1 EMC86425.1 - 1.5e-06 28.0 0.0 2.6e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Complex1_LYR_2 PF13233.6 EMC86425.1 - 0.0074 17.0 1.6 0.025 15.3 1.6 2.0 1 1 0 1 1 1 1 Complex1_LYR-like PDZ_2 PF13180.6 EMC86425.1 - 0.0079 16.5 0.0 0.019 15.3 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 EMC86425.1 - 0.053 13.9 0.0 0.086 13.2 0.0 1.3 1 0 0 1 1 1 0 PDZ domain MCM6_C PF18263.1 EMC86425.1 - 0.48 10.7 2.1 3 8.1 0.1 2.7 2 1 0 2 2 2 0 MCM6 C-terminal winged-helix domain VWA PF00092.28 EMC86426.1 - 1.3e-111 370.7 0.2 9.8e-55 185.5 0.2 3.0 3 0 0 3 3 3 2 von Willebrand factor type A domain fn3 PF00041.21 EMC86426.1 - 2.3e-94 309.9 9.3 4.3e-13 49.4 0.0 8.3 8 0 0 8 8 8 8 Fibronectin type III domain Collagen PF01391.18 EMC86426.1 - 4.1e-37 125.8 167.1 5.5e-09 35.6 25.7 5.4 2 2 3 5 5 5 5 Collagen triple helix repeat (20 copies) VWA_2 PF13519.6 EMC86426.1 - 1.4e-31 109.3 0.0 5.9e-17 62.3 0.0 3.0 3 0 0 3 3 3 2 von Willebrand factor type A domain DUF2369 PF10179.9 EMC86426.1 - 1.4e-07 31.7 0.8 29 5.2 0.0 6.7 7 0 0 7 7 7 0 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.10 EMC86426.1 - 6.1e-07 29.7 0.0 10 6.5 0.0 6.6 7 0 0 7 7 7 1 Interferon-alpha/beta receptor, fibronectin type III DUF4959 PF16323.5 EMC86426.1 - 0.0021 18.3 0.3 1.6 9.1 0.0 4.3 5 0 0 5 5 5 1 Domain of unknown function (DUF4959) Ribosomal_L13 PF00572.18 EMC86427.1 - 5e-07 30.0 0.1 6.5e-07 29.6 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L13 FerI PF08151.12 EMC86427.1 - 0.074 13.2 0.1 0.09 12.9 0.1 1.3 1 0 0 1 1 1 0 FerI (NUC094) domain PH_17 PF18012.1 EMC86428.1 - 2e-28 97.9 0.2 7.6e-28 96.0 0.1 2.1 2 0 0 2 2 2 1 PH domain PH PF00169.29 EMC86428.1 - 2.8e-15 56.7 0.0 4.7e-10 39.9 0.0 2.3 2 0 0 2 2 2 2 PH domain Chitin_synth_2 PF03142.15 EMC86429.1 - 2.9e-18 65.8 4.1 9.9e-15 54.1 0.6 3.4 2 1 0 2 2 2 2 Chitin synthase Glyco_tranf_2_3 PF13641.6 EMC86429.1 - 3.9e-18 66.2 0.0 3.8e-16 59.7 0.0 2.1 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EMC86429.1 - 3.6e-09 36.7 0.0 0.00021 21.2 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 EMC86429.1 - 2.3e-06 27.7 19.0 4.3e-05 23.5 19.0 2.6 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 EMC86429.1 - 0.0016 18.0 0.0 0.0038 16.7 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 21 Homeodomain PF00046.29 EMC86431.1 - 2.2e-29 101.1 17.8 6.8e-08 32.2 0.3 4.4 4 0 0 4 4 4 4 Homeodomain zf_C2H2_ZHX PF18387.1 EMC86431.1 - 1.7e-25 88.4 2.5 7.4e-24 83.1 0.4 2.6 2 0 0 2 2 2 1 Zinc-fingers and homeoboxes C2H2 finger domain Homeobox_KN PF05920.11 EMC86431.1 - 5.5e-18 64.6 7.0 0.0039 17.1 0.2 4.8 4 0 0 4 4 4 4 Homeobox KN domain Homez PF11569.8 EMC86431.1 - 1.5e-07 30.8 4.1 0.76 9.3 0.1 4.4 4 0 0 4 4 4 3 Homeodomain leucine-zipper encoding, Homez OrsD PF12013.8 EMC86431.1 - 0.00061 20.2 0.9 0.18 12.2 0.1 2.8 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-H2C2_5 PF13909.6 EMC86431.1 - 0.0021 17.8 7.8 0.014 15.1 0.5 2.6 2 0 0 2 2 2 2 C2H2-type zinc-finger domain HTH_36 PF13730.6 EMC86431.1 - 0.019 14.9 0.0 0.24 11.4 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain zf-C2H2 PF00096.26 EMC86431.1 - 0.027 14.9 8.1 0.65 10.6 0.7 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type Phage_AlpA PF05930.12 EMC86431.1 - 0.083 12.7 0.3 23 4.9 0.0 2.9 3 0 0 3 3 3 0 Prophage CP4-57 regulatory protein (AlpA) zf-Di19 PF05605.12 EMC86431.1 - 0.86 9.9 4.1 2.3 8.6 4.2 1.7 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 EMC86431.1 - 1.2 10.2 6.7 2.9 8.9 0.5 3.2 3 0 0 3 3 2 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC86431.1 - 1.3 9.6 9.4 4.6 7.9 1.0 3.5 3 0 0 3 3 3 0 Zinc-finger double domain FAM83 PF07894.12 EMC86432.1 - 9.7e-100 333.6 0.1 1.2e-99 333.3 0.1 1.1 1 0 0 1 1 1 1 FAM83 A-H PLDc_2 PF13091.6 EMC86432.1 - 0.00056 19.8 0.0 0.00091 19.1 0.0 1.4 1 0 0 1 1 1 1 PLD-like domain DUF5588 PF17826.1 EMC86433.1 - 1.7e-94 316.7 3.2 2.2e-93 313.0 3.2 1.9 1 1 0 1 1 1 1 Family of unknown function (DUF5588) TPR_12 PF13424.6 EMC86433.1 - 0.081 13.2 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Homeodomain PF00046.29 EMC86434.1 - 6.9e-37 125.1 17.4 7.1e-08 32.2 1.4 5.4 5 0 0 5 5 5 5 Homeodomain zf_C2H2_ZHX PF18387.1 EMC86434.1 - 2.2e-24 84.8 3.9 4.8e-24 83.7 0.6 2.4 2 0 0 2 2 2 1 Zinc-fingers and homeoboxes C2H2 finger domain Homez PF11569.8 EMC86434.1 - 9.9e-21 73.0 4.1 1.1e-11 44.1 0.3 5.3 5 0 0 5 5 5 4 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.11 EMC86434.1 - 3.4e-17 62.0 15.4 0.001 18.9 0.2 5.8 6 0 0 6 6 6 5 Homeobox KN domain AAA PF00004.29 EMC86435.1 - 2e-47 160.9 0.0 4.2e-41 140.5 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Bromodomain PF00439.25 EMC86435.1 - 9.1e-20 70.5 0.0 2.3e-19 69.2 0.0 1.7 1 0 0 1 1 1 1 Bromodomain AAA_lid_3 PF17862.1 EMC86435.1 - 2.4e-13 49.6 0.1 7.4e-13 48.1 0.1 1.8 1 0 0 1 1 1 1 AAA+ lid domain IstB_IS21 PF01695.17 EMC86435.1 - 1.2e-06 28.3 0.0 8.8e-05 22.3 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_16 PF13191.6 EMC86435.1 - 3e-05 24.5 2.7 0.00011 22.6 0.0 3.1 3 2 2 5 5 4 1 AAA ATPase domain AAA_2 PF07724.14 EMC86435.1 - 4.5e-05 23.6 0.0 0.00013 22.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Brr6_like_C_C PF10104.9 EMC86435.1 - 0.00041 20.1 0.6 0.0011 18.8 0.6 1.7 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain AAA_22 PF13401.6 EMC86435.1 - 0.0015 18.8 0.2 0.042 14.1 0.1 3.4 3 1 0 3 3 3 1 AAA domain AAA_5 PF07728.14 EMC86435.1 - 0.0021 18.1 0.0 0.092 12.7 0.0 3.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EMC86435.1 - 0.0031 18.1 0.0 0.055 14.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EMC86435.1 - 0.0046 17.3 0.0 0.035 14.5 0.0 2.4 2 0 0 2 2 2 1 RNA helicase AAA_7 PF12775.7 EMC86435.1 - 0.014 14.9 0.0 0.31 10.6 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region RuvB_N PF05496.12 EMC86435.1 - 0.016 14.9 0.0 0.1 12.3 0.0 2.4 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain DUF2075 PF09848.9 EMC86435.1 - 0.031 13.5 0.0 0.056 12.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_33 PF13671.6 EMC86435.1 - 0.034 14.3 0.0 0.38 10.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 EMC86435.1 - 0.039 13.9 0.0 0.21 11.6 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_11 PF13086.6 EMC86435.1 - 0.085 12.6 0.0 0.41 10.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EMC86435.1 - 0.087 12.2 0.0 0.23 10.8 0.0 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 EMC86435.1 - 0.1 11.8 0.0 0.27 10.4 0.0 1.6 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_25 PF13481.6 EMC86435.1 - 0.1 12.1 0.0 0.29 10.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 EMC86435.1 - 0.12 12.5 0.0 0.79 9.8 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain IMUP PF15761.5 EMC86435.1 - 0.35 11.6 3.2 0.96 10.2 3.2 1.7 1 0 0 1 1 1 0 Immortalisation up-regulated protein Poxvirus_B22R_N PF13169.6 EMC86436.1 - 0.2 12.2 0.2 0.2 12.2 0.2 2.5 2 1 1 3 3 3 0 Poxvirus B22R protein N-terminal Nt_Gln_amidase PF09764.9 EMC86437.1 - 1.3e-62 210.7 0.0 1.5e-62 210.5 0.0 1.0 1 0 0 1 1 1 1 N-terminal glutamine amidase Elongin_A PF06881.11 EMC86438.1 - 0.00073 20.0 2.0 0.00075 20.0 0.1 2.0 2 0 0 2 2 2 1 RNA polymerase II transcription factor SIII (Elongin) subunit A F-box-like PF12937.7 EMC86438.1 - 0.0028 17.5 0.3 0.0097 15.8 0.3 2.0 1 0 0 1 1 1 1 F-box-like Pox_A8 PF04745.12 EMC86438.1 - 0.011 14.8 0.6 0.016 14.3 0.6 1.3 1 0 0 1 1 1 0 VITF-3 subunit protein F-box PF00646.33 EMC86438.1 - 0.07 13.0 0.7 0.32 10.9 0.2 2.5 2 0 0 2 2 2 0 F-box domain Kelch_1 PF01344.25 EMC86439.1 - 4.2e-43 144.7 0.0 2.2e-10 39.9 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EMC86439.1 - 1.9e-35 120.0 1.1 1.6e-05 25.0 0.0 6.5 2 2 4 6 6 6 6 Kelch motif Kelch_4 PF13418.6 EMC86439.1 - 2.6e-25 88.1 0.8 1.5e-05 24.9 0.0 6.8 4 2 2 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 EMC86439.1 - 3.3e-25 87.8 0.0 0.0016 18.7 0.0 6.8 5 2 1 6 6 6 6 Galactose oxidase, central domain BTB PF00651.31 EMC86439.1 - 3.5e-25 88.4 0.4 7.6e-25 87.3 0.4 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 EMC86439.1 - 3.9e-24 84.7 0.4 3.9e-24 84.7 0.4 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_2 PF07646.15 EMC86439.1 - 2.2e-22 78.1 0.1 0.00078 19.3 0.0 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_5 PF13854.6 EMC86439.1 - 3.7e-17 61.9 1.4 0.015 15.3 0.0 6.5 6 0 0 6 6 6 5 Kelch motif DUF1668 PF07893.13 EMC86439.1 - 0.0024 17.3 0.0 1.4 8.2 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1668) DUF3342 PF11822.8 EMC86439.1 - 0.0065 16.6 0.5 0.037 14.2 0.0 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3342) Skp1_POZ PF03931.15 EMC86439.1 - 0.01 16.0 0.0 0.12 12.6 0.0 2.4 3 0 0 3 3 3 0 Skp1 family, tetramerisation domain Annexin PF00191.20 EMC86440.1 - 1e-100 329.8 13.5 1.6e-25 89.0 0.1 4.1 4 0 0 4 4 4 4 Annexin Myb_DNA-bind_7 PF15963.5 EMC86440.1 - 8.7e-06 25.5 2.1 0.42 10.5 0.1 4.1 3 1 1 4 4 4 2 Myb DNA-binding like Acetyltransf_11 PF13720.6 EMC86440.1 - 0.00094 19.6 0.4 4.6 7.8 0.0 3.7 4 0 0 4 4 4 2 Udp N-acetylglucosamine O-acyltransferase; Domain 2 DUF5343 PF17278.2 EMC86440.1 - 0.022 14.8 3.9 0.7 10.0 0.1 3.5 4 0 0 4 4 4 0 Family of unknown function (DUF5343) CdvA PF18822.1 EMC86440.1 - 0.2 11.5 5.0 0.42 10.4 0.5 3.1 2 1 1 3 3 3 0 CdvA-like coiled-coil domain DUF2312 PF10073.9 EMC86440.1 - 1.3 8.7 8.4 4.9 6.9 0.7 3.9 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2312) FAM91_C PF14648.6 EMC86441.1 - 3.6e-182 606.0 0.0 5.6e-182 605.4 0.0 1.3 1 0 0 1 1 1 1 FAM91 C-terminus FAM91_N PF14647.6 EMC86441.1 - 4.8e-139 462.9 0.2 6.7e-139 462.5 0.2 1.1 1 0 0 1 1 1 1 FAM91 N-terminus C2 PF00168.30 EMC86442.1 - 1.4e-72 240.5 0.1 4e-16 59.2 0.0 7.4 6 1 0 6 6 6 6 C2 domain Ferlin_C PF16165.5 EMC86442.1 - 7.2e-41 139.7 3.6 1.1e-38 132.5 0.1 4.5 2 2 2 4 4 4 2 Ferlin C-terminus FerB PF08150.12 EMC86442.1 - 1.6e-31 108.7 0.2 7.7e-31 106.5 0.1 2.4 2 0 0 2 2 2 1 FerB (NUC096) domain FerI PF08151.12 EMC86442.1 - 1.7e-20 72.8 0.0 5e-20 71.3 0.0 1.9 1 0 0 1 1 1 1 FerI (NUC094) domain PTPlike_phytase PF14566.6 EMC86442.1 - 0.14 12.3 0.1 0.49 10.5 0.1 2.0 1 0 0 1 1 1 0 Inositol hexakisphosphate GP41 PF00517.17 EMC86442.1 - 0.19 11.6 0.2 0.57 10.1 0.2 1.7 1 0 0 1 1 1 0 Retroviral envelope protein Synaptobrevin PF00957.21 EMC86442.1 - 1.8 8.4 7.1 4 7.3 7.1 1.5 1 0 0 1 1 1 0 Synaptobrevin TRC8_N PF13705.6 EMC86443.1 - 4.1e-166 553.8 34.1 4.7e-166 553.6 34.1 1.0 1 0 0 1 1 1 1 TRC8 N-terminal domain zf-RING_2 PF13639.6 EMC86443.1 - 4.5e-09 36.5 8.6 4.5e-09 36.5 8.6 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC86443.1 - 7.1e-09 35.4 7.6 7.1e-09 35.4 7.6 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMC86443.1 - 9.9e-08 32.2 8.3 4.1e-07 30.2 8.3 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EMC86443.1 - 1.6e-06 27.9 8.0 1.6e-06 27.9 8.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC86443.1 - 6.8e-05 22.7 8.0 6.8e-05 22.7 8.0 1.8 2 0 0 2 2 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EMC86443.1 - 7.1e-05 22.8 5.7 0.00099 19.1 5.7 2.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EMC86443.1 - 7.9e-05 22.4 5.4 7.9e-05 22.4 5.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC86443.1 - 8.1e-05 22.4 4.9 0.0002 21.1 4.9 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 EMC86443.1 - 0.00047 19.8 6.1 0.00047 19.8 6.1 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EMC86443.1 - 0.0019 18.2 7.9 0.0056 16.7 7.9 1.8 1 0 0 1 1 1 1 RING-type zinc-finger FANCL_C PF11793.8 EMC86443.1 - 0.067 13.4 8.5 2.1 8.6 8.5 3.0 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_10 PF16685.5 EMC86443.1 - 0.33 11.1 3.8 0.77 9.9 3.8 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-P11 PF03854.14 EMC86443.1 - 0.52 10.0 5.4 2.2 8.0 5.4 2.1 1 0 0 1 1 1 0 P-11 zinc finger Zf_RING PF16744.5 EMC86443.1 - 0.95 9.6 7.3 0.37 10.9 4.3 1.8 2 0 0 2 2 2 0 KIAA1045 RING finger Zn_ribbon_17 PF17120.5 EMC86443.1 - 5.8 6.6 13.1 0.68 9.6 8.0 2.1 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type TatD_DNase PF01026.21 EMC86444.1 - 6.1e-54 183.1 0.0 7.4e-54 182.8 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Amidohydro_2 PF04909.14 EMC86444.1 - 0.1 12.3 0.0 8.2 6.1 0.0 2.5 2 1 1 3 3 3 0 Amidohydrolase IMD PF08397.11 EMC86445.1 - 7.5e-107 355.7 3.8 9.7e-107 355.3 3.8 1.1 1 0 0 1 1 1 1 IRSp53/MIM homology domain WH2 PF02205.20 EMC86445.1 - 6.3e-07 29.0 0.0 1.9e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 WH2 motif Gp58 PF07902.11 EMC86445.1 - 0.043 12.1 0.7 0.055 11.7 0.7 1.1 1 0 0 1 1 1 0 gp58-like protein CK2S PF15011.6 EMC86445.1 - 0.049 13.5 1.4 0.11 12.4 0.7 2.1 2 0 0 2 2 2 0 Casein Kinase 2 substrate OmpH PF03938.14 EMC86445.1 - 0.57 10.5 8.7 1.2 9.5 8.7 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) SE PF08491.10 EMC86446.1 - 7.2e-111 369.7 0.0 9.2e-111 369.3 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 EMC86446.1 - 2.9e-21 76.1 0.0 4.6e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EMC86446.1 - 1.5e-10 41.2 0.1 0.00038 20.1 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMC86446.1 - 0.00014 21.0 0.1 0.26 10.3 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox PF00070.27 EMC86446.1 - 0.00017 22.1 0.1 0.00051 20.5 0.1 1.8 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMC86446.1 - 0.00024 21.3 0.1 0.00054 20.1 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain TrkA_N PF02254.18 EMC86446.1 - 0.002 18.4 0.1 0.0043 17.3 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain GMC_oxred_N PF00732.19 EMC86446.1 - 0.008 15.6 0.0 3.5 6.9 0.0 2.2 2 0 0 2 2 2 2 GMC oxidoreductase 3HCDH_N PF02737.18 EMC86446.1 - 0.0082 16.0 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 EMC86446.1 - 0.009 15.3 0.0 0.018 14.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EMC86446.1 - 0.024 14.3 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Thi4 PF01946.17 EMC86446.1 - 0.024 13.9 0.0 0.16 11.1 0.0 2.0 2 0 0 2 2 2 0 Thi4 family Trp_halogenase PF04820.14 EMC86446.1 - 0.025 13.5 0.2 2.8 6.7 0.1 2.5 2 1 1 3 3 3 0 Tryptophan halogenase Sacchrp_dh_NADP PF03435.18 EMC86446.1 - 0.028 14.7 0.0 0.065 13.5 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_Gly3P_dh_N PF01210.23 EMC86446.1 - 0.033 14.2 0.0 0.068 13.2 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_2 PF03446.15 EMC86446.1 - 0.046 13.9 0.0 0.14 12.3 0.0 1.8 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 EMC86446.1 - 0.12 12.5 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EMC86446.1 - 0.18 12.4 0.0 0.54 10.9 0.0 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Strumpellin PF10266.9 EMC86447.1 - 0 1662.0 21.5 0 1661.8 21.5 1.0 1 0 0 1 1 1 1 Hereditary spastic paraplegia protein strumpellin EF-hand_9 PF14658.6 EMC86447.1 - 0.15 12.4 0.0 0.74 10.2 0.0 2.3 1 0 0 1 1 1 0 EF-hand domain DUF3502 PF12010.8 EMC86447.1 - 1.5 9.5 5.9 13 6.4 0.2 4.4 4 2 1 5 5 5 0 Domain of unknown function (DUF3502) zf-Nse PF11789.8 EMC86448.1 - 1.7e-19 69.4 2.1 3.1e-19 68.5 2.1 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EMC86448.1 - 7.4e-08 32.3 0.1 2e-07 30.9 0.1 1.8 1 0 0 1 1 1 1 RING-type zinc-finger Rtf2 PF04641.12 EMC86448.1 - 0.00047 19.6 3.9 0.00047 19.6 3.9 1.8 1 1 0 1 1 1 1 Rtf2 RING-finger zf-MIZ PF02891.20 EMC86448.1 - 0.0008 19.1 1.9 0.0025 17.5 1.9 1.9 1 1 0 1 1 1 1 MIZ/SP-RING zinc finger HalX PF08663.10 EMC86448.1 - 0.0045 17.3 0.7 0.03 14.6 0.2 2.3 1 1 1 2 2 2 1 HalX domain Transferase PF02458.15 EMC86448.1 - 0.03 13.0 0.5 0.044 12.4 0.5 1.2 1 0 0 1 1 1 0 Transferase family TCTP PF00838.17 EMC86448.1 - 0.037 14.4 3.8 0.55 10.6 1.6 2.7 1 1 1 2 2 2 0 Translationally controlled tumour protein zf-C3HC4_2 PF13923.6 EMC86448.1 - 0.045 13.6 1.3 0.19 11.6 0.1 2.6 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC86448.1 - 0.057 13.7 0.6 0.057 13.7 0.6 2.0 2 0 0 2 2 2 0 Ring finger domain U-box PF04564.15 EMC86448.1 - 0.063 13.5 0.1 0.2 11.9 0.1 1.8 1 1 0 1 1 1 0 U-box domain THP2 PF09432.10 EMC86448.1 - 0.082 13.0 3.7 0.16 12.1 3.7 1.5 1 0 0 1 1 1 0 Tho complex subunit THP2 L31 PF09784.9 EMC86448.1 - 2.6 8.5 6.1 1.3 9.5 3.1 2.2 1 1 1 2 2 2 0 Mitochondrial ribosomal protein L31 Pkinase PF00069.25 EMC86449.1 - 2.7e-07 30.2 0.0 3.2e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Yae1_N PF09811.9 EMC86450.1 - 9.4e-10 38.0 29.8 0.0025 17.5 6.8 3.3 1 1 1 2 2 2 2 Essential protein Yae1, N terminal LRAT PF04970.13 EMC86452.1 - 1.5e-13 51.1 0.3 9e-06 26.0 0.2 2.4 1 1 1 2 2 2 2 Lecithin retinol acyltransferase NLPC_P60 PF00877.19 EMC86452.1 - 0.084 12.9 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 NlpC/P60 family Bacillus_HBL PF05791.11 EMC86453.1 - 0.00014 21.7 7.1 3.5 7.4 0.4 4.1 1 1 4 5 5 5 4 Bacillus haemolytic enterotoxin (HBL) DUF1884 PF08967.10 EMC86453.1 - 0.0033 17.7 11.8 19 5.5 1.0 5.9 1 1 5 6 6 6 2 Domain of unknown function (DUF1884) TM_helix PF05552.12 EMC86453.1 - 0.04 13.9 7.5 1e+02 3.0 0.0 6.3 2 2 3 7 7 7 0 Conserved TM helix IN_DBD_C PF00552.21 EMC86454.1 - 5.7e-15 54.3 0.9 8e-15 53.9 0.9 1.3 1 0 0 1 1 1 1 Integrase DNA binding domain Branch PF02485.21 EMC86455.1 - 1.4e-48 165.6 0.8 2.2e-48 165.0 0.3 1.6 2 0 0 2 2 2 1 Core-2/I-Branching enzyme Arena_nucleocap PF00843.17 EMC86455.1 - 0.13 11.1 0.0 0.18 10.7 0.0 1.1 1 0 0 1 1 1 0 Arenavirus nucleocapsid N-terminal domain Ank_4 PF13637.6 EMC86456.1 - 1.4e-18 67.0 0.0 5.3e-10 39.6 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC86456.1 - 1.8e-15 56.8 0.1 6.5e-09 35.9 0.1 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) RAMA PF18755.1 EMC86456.1 - 1.3e-14 54.5 0.2 3.9e-14 53.0 0.2 1.8 1 0 0 1 1 1 1 Restriction Enzyme Adenine Methylase Associated Ank_2 PF12796.7 EMC86456.1 - 1.4e-14 54.4 0.0 1.1e-09 38.7 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EMC86456.1 - 3e-11 43.2 0.1 0.0046 17.4 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 EMC86456.1 - 8.4e-09 35.0 0.0 0.003 17.9 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat NAD_kinase PF01513.21 EMC86456.1 - 0.024 13.8 0.0 0.085 12.0 0.0 1.9 1 0 0 1 1 1 0 ATP-NAD kinase DUF1154 PF06631.11 EMC86456.1 - 0.026 14.6 2.8 0.13 12.3 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1154) Ank_4 PF13637.6 EMC86457.1 - 2.4e-16 59.8 0.2 2e-09 37.8 0.1 2.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC86457.1 - 1.2e-14 54.1 0.1 1.2e-05 25.5 0.1 2.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC86457.1 - 2.1e-13 50.7 0.0 3.5e-11 43.5 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC86457.1 - 5.2e-11 41.8 0.0 0.00076 19.8 0.0 2.7 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EMC86457.1 - 3.6e-10 39.8 0.0 3.6e-05 24.0 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat HTH_42 PF06224.12 EMC86457.1 - 0.11 12.0 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 Winged helix DNA-binding domain HMG-CoA_red PF00368.18 EMC86458.1 - 7.4e-146 485.9 1.2 9.9e-146 485.4 1.2 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Sterol-sensing PF12349.8 EMC86458.1 - 7.7e-17 61.5 3.5 1.5e-16 60.6 3.5 1.4 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 EMC86458.1 - 1.3e-08 33.5 2.0 1.9e-08 32.9 2.0 1.2 1 0 0 1 1 1 1 Patched family IMS PF00817.20 EMC86459.1 - 2.2e-44 151.1 0.0 8e-44 149.3 0.0 2.0 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.8 EMC86459.1 - 6.3e-17 62.4 0.3 1.6e-16 61.1 0.3 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 EMC86459.1 - 3.7e-09 36.4 0.1 8.1e-09 35.3 0.1 1.6 1 0 0 1 1 1 1 IMS family HHH motif zf-C2H2_12 PF18658.1 EMC86459.1 - 2.5e-05 23.8 1.4 0.14 11.7 0.1 2.6 2 0 0 2 2 2 2 Zinc-finger C2H2-type Cdd1 PF11731.8 EMC86459.1 - 0.065 13.5 0.0 0.22 11.8 0.0 1.9 1 0 0 1 1 1 0 Pathogenicity locus zf-Di19 PF05605.12 EMC86459.1 - 0.11 12.8 4.5 7.5 6.9 0.4 2.9 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 EMC86459.1 - 1.2 9.7 5.1 9.7 6.9 0.0 3.5 3 0 0 3 3 3 0 Zinc finger, C2H2 type Ank_2 PF12796.7 EMC86460.1 - 2.4e-45 153.0 17.2 2e-16 60.3 0.2 3.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC86460.1 - 1.1e-31 105.3 2.2 9.9e-05 22.5 0.0 7.4 7 0 0 7 7 7 7 Ankyrin repeat Ank_4 PF13637.6 EMC86460.1 - 8.8e-29 99.5 3.9 2.1e-10 40.9 0.2 5.1 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC86460.1 - 4.1e-27 93.9 1.7 2.8e-09 37.1 0.1 5.4 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EMC86460.1 - 8.3e-23 79.8 10.8 7.7e-05 23.0 0.0 7.2 7 0 0 7 7 7 5 Ankyrin repeat Death PF00531.22 EMC86460.1 - 0.02 15.0 2.7 0.023 14.8 1.2 1.9 2 0 0 2 2 2 0 Death domain SRCR_2 PF15494.6 EMC86461.1 - 0.12 13.0 2.8 0.24 11.9 0.8 2.6 2 0 0 2 2 2 0 Scavenger receptor cysteine-rich domain GerD PF17898.1 EMC86461.1 - 0.71 9.8 5.7 0.53 10.2 1.8 2.6 3 0 0 3 3 3 0 Spore germination GerD central core domain YlqD PF11068.8 EMC86461.1 - 8.9 6.7 13.3 8.3 6.8 3.0 3.2 3 1 1 4 4 4 0 YlqD protein MFS_1 PF07690.16 EMC86462.1 - 3.2e-34 118.4 30.5 5.7e-24 84.7 14.3 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMC86462.1 - 3.9e-32 111.7 18.1 3.6e-29 101.9 3.7 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter Pentapeptide_4 PF13599.6 EMC86462.1 - 1.1e-06 28.7 8.7 2e-06 27.9 8.7 1.4 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 EMC86462.1 - 0.0007 19.7 5.2 0.0007 19.7 5.2 2.0 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) MFS_4 PF06779.14 EMC86462.1 - 0.00097 18.5 9.4 0.00097 18.5 9.4 2.0 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_2 PF13347.6 EMC86462.1 - 0.003 16.2 11.7 0.003 16.2 11.7 2.5 2 0 0 2 2 2 1 MFS/sugar transport protein Pentapeptide PF00805.22 EMC86462.1 - 0.024 14.3 1.2 0.069 12.8 0.8 1.9 1 1 1 2 2 2 0 Pentapeptide repeats (8 copies) Neurensin PF14927.6 EMC86462.1 - 0.088 12.5 0.3 0.84 9.3 0.0 2.4 2 0 0 2 2 2 0 Neurensin MFS_3 PF05977.13 EMC86462.1 - 0.28 9.5 8.0 0.51 8.7 4.2 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector DUF1897 PF09005.10 EMC86462.1 - 2.2 7.9 4.2 8.8 5.9 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1897) 7tm_1 PF00001.21 EMC86463.1 - 3.4e-39 134.8 38.2 7.6e-38 130.3 38.2 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC86463.1 - 0.00032 20.4 29.2 0.00032 20.4 29.2 2.1 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx PRRSV_2b PF07069.11 EMC86463.1 - 0.034 14.7 0.8 0.034 14.7 0.8 3.7 4 1 1 5 5 5 0 Porcine reproductive and respiratory syndrome virus 2b 7tm_1 PF00001.21 EMC86464.1 - 3.7e-43 147.7 31.0 5.1e-43 147.3 31.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4212 PF13937.6 EMC86464.1 - 0.0044 17.4 5.5 0.0053 17.1 1.6 2.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4212) 7TM_GPCR_Srw PF10324.9 EMC86464.1 - 0.14 11.4 29.9 0.88 8.8 29.9 2.0 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srx PF10328.9 EMC86464.1 - 1.9 8.0 36.4 6.8 6.2 35.8 2.0 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.21 EMC86465.1 - 2.2e-42 145.2 24.2 3.2e-42 144.7 24.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) NB PF04159.13 EMC86465.1 - 0.19 11.8 1.7 0.41 10.7 0.7 2.1 1 1 1 2 2 2 0 NB glycoprotein S_100 PF01023.19 EMC86466.1 - 1.8e-20 72.4 0.4 2.9e-20 71.7 0.4 1.4 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.6 EMC86466.1 - 2.4e-06 27.9 1.5 3.5e-06 27.4 1.5 1.4 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EMC86466.1 - 3.5e-06 26.2 1.6 3.3e-05 23.1 0.6 2.4 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 EMC86466.1 - 0.00035 20.3 0.8 0.053 13.5 0.2 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EMC86466.1 - 0.035 13.6 3.1 0.18 11.4 0.8 2.3 2 0 0 2 2 2 0 EF hand DUF826 PF05696.11 EMC86466.1 - 0.045 13.8 1.9 0.051 13.7 1.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF826) EF-hand_8 PF13833.6 EMC86466.1 - 0.18 11.7 2.4 0.36 10.7 1.6 2.1 1 1 1 2 2 2 0 EF-hand domain pair CRF-BP PF05428.11 EMC86467.1 - 3.4e-171 568.0 0.1 3.8e-171 567.8 0.1 1.0 1 0 0 1 1 1 1 Corticotropin-releasing factor binding protein (CRF-BP) Pep_M12B_propep PF01562.19 EMC86467.1 - 0.14 12.3 0.0 0.26 11.5 0.0 1.3 1 0 0 1 1 1 0 Reprolysin family propeptide OCRE PF17780.1 EMC86468.1 - 3.2e-18 65.5 14.4 3.2e-18 65.5 14.4 2.9 3 0 0 3 3 3 1 OCRE domain G-patch PF01585.23 EMC86468.1 - 2.2e-15 56.3 5.2 4.2e-15 55.4 5.2 1.5 1 0 0 1 1 1 1 G-patch domain FHA PF00498.26 EMC86468.1 - 1e-13 51.4 0.0 2.8e-13 50.0 0.0 1.8 1 0 0 1 1 1 1 FHA domain G-patch_2 PF12656.7 EMC86468.1 - 1e-05 25.5 0.6 1e-05 25.5 0.6 2.6 3 0 0 3 3 3 1 G-patch domain Yop-YscD_cpl PF16697.5 EMC86468.1 - 2.4e-05 24.6 0.3 0.00018 21.7 0.0 2.5 3 0 0 3 3 3 1 Inner membrane component of T3SS, cytoplasmic domain DUF4551 PF15087.6 EMC86468.1 - 2.6 6.8 9.0 5.8 5.6 9.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) WD40 PF00400.32 EMC86470.1 - 4.5e-15 55.8 8.6 0.0019 19.0 0.0 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat PROL5-SMR PF15621.6 EMC86470.1 - 0.15 12.6 0.0 0.31 11.6 0.0 1.5 1 0 0 1 1 1 0 Proline-rich submaxillary gland androgen-regulated family TBCA PF02970.16 EMC86471.1 - 3.4e-23 81.8 6.2 3.8e-23 81.6 6.2 1.0 1 0 0 1 1 1 1 Tubulin binding cofactor A Pkip-1 PF06878.11 EMC86471.1 - 0.02 15.0 0.8 0.025 14.7 0.8 1.2 1 0 0 1 1 1 0 Pkip-1 protein RVT_1 PF00078.27 EMC86472.1 - 0.031 13.8 0.0 0.063 12.8 0.0 1.6 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) SCAMP PF04144.13 EMC86473.1 - 5.5e-73 245.0 17.3 6.7e-73 244.7 17.3 1.1 1 0 0 1 1 1 1 SCAMP family L_HMGIC_fpl PF10242.9 EMC86474.1 - 2.2e-64 217.0 8.8 2.5e-64 216.8 8.8 1.0 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein Claudin_2 PF13903.6 EMC86474.1 - 5.1e-06 26.4 7.0 1.3e-05 25.0 7.0 1.6 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Nucleos_tra2_C PF07662.13 EMC86474.1 - 0.0012 18.8 0.5 0.0012 18.8 0.5 1.8 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter C-terminus Claudin_3 PF06653.11 EMC86474.1 - 0.0098 15.8 5.6 0.0098 15.8 5.6 1.7 2 0 0 2 2 2 1 Tight junction protein, Claudin-like PMP22_Claudin PF00822.20 EMC86474.1 - 0.095 12.6 16.2 0.22 11.4 16.2 1.8 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family Phage_holin_1 PF04531.13 EMC86474.1 - 3.3 8.3 5.3 5.5 7.6 0.0 2.5 3 0 0 3 3 3 0 Bacteriophage holin Sulfatase PF00884.23 EMC86475.1 - 4.4e-50 170.8 0.0 7e-50 170.2 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 EMC86475.1 - 0.0011 19.6 0.1 0.0054 17.5 0.0 2.0 2 0 0 2 2 2 1 C-terminal region of aryl-sulfatase DUF4994 PF16385.5 EMC86475.1 - 0.02 14.8 0.0 0.053 13.4 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function Phosphodiest PF01663.22 EMC86475.1 - 0.021 14.5 0.0 0.03 13.9 0.0 1.4 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase DUF1501 PF07394.12 EMC86475.1 - 0.045 12.8 0.1 0.091 11.8 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1501) DAO PF01266.24 EMC86476.1 - 2.5e-62 211.5 0.0 3.6e-62 211.0 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase GCV_T PF01571.21 EMC86476.1 - 1.8e-42 145.5 0.0 2.5e-42 145.1 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain FAO_M PF16350.5 EMC86476.1 - 5e-13 49.2 0.1 1.2e-12 47.9 0.1 1.7 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain Pyr_redox_3 PF13738.6 EMC86476.1 - 3.2e-07 29.9 0.0 0.00019 20.8 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMC86476.1 - 4.1e-05 23.7 0.4 0.0025 18.0 0.4 2.7 1 1 1 2 2 2 1 NAD(P)-binding Rossmann-like domain SoxG PF04268.12 EMC86476.1 - 0.00011 22.4 0.0 0.00033 20.8 0.0 1.7 1 1 1 2 2 2 1 Sarcosine oxidase, gamma subunit family FAD_binding_2 PF00890.24 EMC86476.1 - 0.00015 21.0 0.1 0.00034 19.8 0.1 1.6 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 EMC86476.1 - 0.002 17.4 0.3 0.0035 16.6 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EMC86476.1 - 0.0021 17.4 0.0 0.0032 16.8 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMC86476.1 - 0.0033 16.7 0.1 0.0057 15.9 0.1 1.3 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.6 EMC86476.1 - 0.021 14.8 0.1 0.078 13.0 0.1 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 EMC86476.1 - 0.031 13.3 0.1 0.049 12.7 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein ApbA PF02558.16 EMC86476.1 - 0.039 13.6 0.1 0.08 12.6 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA HI0933_like PF03486.14 EMC86476.1 - 0.094 11.4 0.3 0.57 8.8 0.2 2.1 3 0 0 3 3 3 0 HI0933-like protein Pyr_redox PF00070.27 EMC86476.1 - 0.094 13.3 0.2 0.25 11.9 0.2 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EMC86476.1 - 0.15 12.3 0.0 1 9.7 0.0 2.2 2 0 0 2 2 2 0 TrkA-N domain S-methyl_trans PF02574.16 EMC86477.1 - 3.8e-49 167.9 0.0 4.8e-49 167.6 0.0 1.1 1 0 0 1 1 1 1 Homocysteine S-methyltransferase JMY PF15871.5 EMC86478.1 - 7.9e-165 548.4 24.4 7.9e-165 548.4 24.4 2.4 2 1 0 2 2 2 1 Junction-mediating and -regulatory protein WH2 PF02205.20 EMC86478.1 - 0.0019 18.0 0.2 0.0019 18.0 0.2 3.4 4 0 0 4 4 4 1 WH2 motif GAT PF03127.14 EMC86478.1 - 0.13 12.6 7.8 0.15 12.3 0.7 3.2 3 0 0 3 3 3 0 GAT domain WH1 PF00568.23 EMC86479.1 - 4.8e-35 119.9 0.3 9.7e-35 118.9 0.3 1.5 1 0 0 1 1 1 1 WH1 domain TMF_TATA_bd PF12325.8 EMC86479.1 - 0.00047 20.3 18.9 0.00047 20.3 18.9 2.9 2 1 1 3 3 3 1 TATA element modulatory factor 1 TATA binding DUF812 PF05667.11 EMC86479.1 - 0.00051 19.1 20.6 0.00073 18.6 20.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF812) HMMR_N PF15905.5 EMC86479.1 - 0.0012 18.4 23.3 0.0012 18.4 23.3 1.9 2 0 0 2 2 2 1 Hyaluronan mediated motility receptor N-terminal GAS PF13851.6 EMC86479.1 - 0.0026 17.1 19.1 0.0026 17.1 19.1 2.6 2 1 1 3 3 3 2 Growth-arrest specific micro-tubule binding DUF1664 PF07889.12 EMC86479.1 - 0.005 16.9 14.8 0.073 13.1 7.1 3.2 1 1 2 3 3 3 1 Protein of unknown function (DUF1664) BLOC1_2 PF10046.9 EMC86479.1 - 0.012 15.8 7.5 0.012 15.8 7.5 3.4 2 1 2 4 4 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DMPK_coil PF08826.10 EMC86479.1 - 0.023 14.8 5.6 0.023 14.8 5.6 3.4 2 1 1 3 3 3 0 DMPK coiled coil domain like DUF4164 PF13747.6 EMC86479.1 - 0.025 14.9 11.8 0.025 14.9 11.8 3.4 2 1 2 4 4 3 0 Domain of unknown function (DUF4164) Nsp1_C PF05064.13 EMC86479.1 - 0.04 13.7 23.0 0.42 10.4 10.9 2.7 1 1 1 2 2 2 0 Nsp1-like C-terminal region FAP206 PF12018.8 EMC86479.1 - 0.046 13.2 19.2 0.25 10.8 7.7 3.3 2 1 1 3 3 3 0 Domain of unknown function APG6_N PF17675.1 EMC86479.1 - 0.063 13.8 41.3 0.044 14.3 23.0 3.3 1 1 1 2 2 2 0 Apg6 coiled-coil region FUSC PF04632.12 EMC86479.1 - 0.11 11.0 8.0 0.15 10.5 8.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family IFT57 PF10498.9 EMC86479.1 - 0.13 11.2 27.3 0.35 9.8 27.1 1.8 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 FPP PF05911.11 EMC86479.1 - 0.16 10.1 32.4 0.057 11.6 27.5 1.9 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil ATG16 PF08614.11 EMC86479.1 - 0.18 12.0 38.2 1.2 9.3 20.3 2.9 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) NPV_P10 PF05531.12 EMC86479.1 - 0.2 12.2 12.0 0.42 11.1 1.0 3.1 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Phage_GP20 PF06810.11 EMC86479.1 - 0.23 11.2 23.8 1.5 8.6 15.6 3.7 1 1 1 2 2 2 0 Phage minor structural protein GP20 Prominin PF05478.11 EMC86479.1 - 0.43 8.5 10.6 0.8 7.6 10.6 1.5 1 0 0 1 1 1 0 Prominin HemX PF04375.14 EMC86479.1 - 0.51 9.6 24.6 0.15 11.3 10.3 2.4 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Laminin_II PF06009.12 EMC86479.1 - 0.59 10.2 21.1 0.067 13.2 8.7 2.8 2 1 1 3 3 3 0 Laminin Domain II CALCOCO1 PF07888.11 EMC86479.1 - 0.6 8.9 32.4 0.073 11.9 26.0 2.4 2 1 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Fmp27_WPPW PF10359.9 EMC86479.1 - 0.65 8.8 17.3 1 8.1 16.3 1.7 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF641 PF04859.12 EMC86479.1 - 0.85 10.0 20.5 1.7 9.0 7.2 3.6 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) FlaC_arch PF05377.11 EMC86479.1 - 1.2 9.6 16.9 8.5 6.9 1.9 4.3 1 1 1 3 3 3 0 Flagella accessory protein C (FlaC) CENP-F_leu_zip PF10473.9 EMC86479.1 - 1.3 9.1 36.8 0.08 13.0 27.3 3.2 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF948 PF06103.11 EMC86479.1 - 1.5 9.1 11.9 5.9 7.2 3.1 3.3 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF4407 PF14362.6 EMC86479.1 - 1.6 8.0 19.8 4.1 6.7 19.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DivIC PF04977.15 EMC86479.1 - 1.7 8.5 33.8 0.44 10.3 4.4 4.5 3 2 1 4 4 3 0 Septum formation initiator DUF2968 PF11180.8 EMC86479.1 - 1.9 8.1 27.5 0.49 10.0 3.2 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2968) kleA_kleC PF17383.2 EMC86479.1 - 2 8.8 8.3 2.4 8.6 1.4 2.9 2 1 0 2 2 2 0 Uncharacterized KorC regulated protein A CENP-K PF11802.8 EMC86479.1 - 2 7.9 24.7 0.22 11.0 20.1 1.6 2 0 0 2 2 2 0 Centromere-associated protein K PKcGMP_CC PF16808.5 EMC86479.1 - 2.1 8.3 14.1 0.067 13.1 3.1 3.7 3 1 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase NAM-associated PF14303.6 EMC86479.1 - 2.1 9.0 16.0 42 4.8 16.0 2.4 1 1 0 1 1 1 0 No apical meristem-associated C-terminal domain Bacillus_HBL PF05791.11 EMC86479.1 - 2.2 8.1 20.2 0.51 10.1 5.6 2.7 2 1 1 3 3 2 0 Bacillus haemolytic enterotoxin (HBL) DUF3461 PF11944.8 EMC86479.1 - 3 8.0 15.3 0.25 11.5 4.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3461) DUF489 PF04356.12 EMC86479.1 - 3.4 7.6 10.9 1.4 8.9 6.5 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF489) Fzo_mitofusin PF04799.13 EMC86479.1 - 3.5 7.2 20.5 3.2 7.3 12.0 3.0 1 1 2 3 3 3 0 fzo-like conserved region FapA PF03961.13 EMC86479.1 - 3.7 6.0 20.5 1.3 7.5 15.4 2.2 1 1 1 2 2 2 0 Flagellar Assembly Protein A DHR10 PF18595.1 EMC86479.1 - 3.7 7.6 42.2 1.4 9.0 20.8 3.6 2 1 2 4 4 4 0 Designed helical repeat protein 10 domain Leu_zip PF15294.6 EMC86479.1 - 4 6.9 28.3 1.4 8.3 24.8 2.1 1 1 0 1 1 1 0 Leucine zipper Tropomyosin PF00261.20 EMC86479.1 - 4.3 6.6 30.6 0.95 8.8 25.3 2.2 2 1 0 2 2 2 0 Tropomyosin DUF2203 PF09969.9 EMC86479.1 - 5.1 7.8 16.8 10 6.9 11.6 3.0 2 1 2 4 4 4 0 Uncharacterized conserved protein (DUF2203) Uso1_p115_C PF04871.13 EMC86479.1 - 5.3 7.4 37.0 0.44 10.9 19.5 3.1 2 1 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Syntaxin-6_N PF09177.11 EMC86479.1 - 6 7.5 19.3 1.1 9.9 8.9 3.3 2 1 2 4 4 4 0 Syntaxin 6, N-terminal DUF4559 PF15112.6 EMC86479.1 - 6.6 6.3 17.7 19 4.8 0.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4559) ADIP PF11559.8 EMC86479.1 - 6.6 6.8 36.1 0.19 11.8 12.9 2.7 2 1 1 3 3 2 0 Afadin- and alpha -actinin-Binding XhlA PF10779.9 EMC86479.1 - 6.8 7.0 19.0 0.68 10.2 3.4 3.5 2 1 0 3 3 3 0 Haemolysin XhlA Fib_alpha PF08702.10 EMC86479.1 - 6.9 6.8 21.3 1.8 8.7 11.5 2.6 2 1 1 3 3 2 0 Fibrinogen alpha/beta chain family Prefoldin_2 PF01920.20 EMC86479.1 - 7.2 6.6 35.0 0.62 10.0 7.0 4.4 2 1 2 4 4 4 0 Prefoldin subunit OmpH PF03938.14 EMC86479.1 - 7.5 6.9 32.6 0.21 11.9 18.0 3.4 2 1 1 3 3 3 0 Outer membrane protein (OmpH-like) CorA PF01544.18 EMC86479.1 - 8.4 5.6 12.6 6.4 6.0 9.7 1.8 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Lsr2 PF11774.8 EMC86479.1 - 9 6.5 7.6 47 4.2 0.0 3.4 2 1 1 3 3 3 0 Lsr2 Fez1 PF06818.15 EMC86479.1 - 9.3 6.6 31.0 2.2 8.7 22.5 2.8 1 1 1 2 2 2 0 Fez1 FTCD_C PF04961.12 EMC86479.1 - 9.6 5.9 10.8 1.6 8.5 3.1 2.5 3 0 0 3 3 2 0 Formiminotransferase-cyclodeaminase PAP_assoc PF03828.19 EMC86480.1 - 4.1e-15 55.7 0.0 8.5e-15 54.7 0.0 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EMC86480.1 - 0.00027 21.2 0.0 0.0006 20.1 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Tom37 PF10568.9 EMC86481.1 - 1.5e-33 115.7 0.2 2.5e-33 115.0 0.2 1.3 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 EMC86481.1 - 1.5e-23 82.3 0.9 3.1e-23 81.3 0.3 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EMC86481.1 - 5.1e-17 62.4 0.0 8.9e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 EMC86481.1 - 9.3e-08 32.0 0.0 2.1e-07 30.9 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EMC86481.1 - 0.045 13.9 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EMC86481.1 - 0.049 13.9 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Serinc PF03348.15 EMC86482.1 - 7.6e-164 545.7 34.5 8.5e-164 545.5 34.5 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) DUF5336 PF17270.2 EMC86482.1 - 0.83 9.3 5.3 1.8 8.2 4.0 2.1 1 1 0 1 1 1 0 Family of unknown function (DUF5336) Pkinase PF00069.25 EMC86483.1 - 1.8e-62 211.1 0.0 2.1e-62 210.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC86483.1 - 1.1e-24 87.1 0.0 1.6e-24 86.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC86483.1 - 0.0011 18.4 0.0 0.0016 17.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 EMC86483.1 - 0.0012 18.0 0.1 0.0018 17.4 0.1 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 APH PF01636.23 EMC86483.1 - 0.0071 16.3 0.1 0.011 15.7 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EMC86483.1 - 0.12 11.1 0.0 0.17 10.6 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase RIO1 PF01163.22 EMC86483.1 - 0.15 11.6 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 RIO1 family S36_mt PF10937.8 EMC86484.1 - 0.0037 18.8 0.0 0.0044 18.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S36, mitochondrial CENP-H PF05837.12 EMC86485.1 - 1.6e-22 80.0 6.4 1.8e-22 79.9 6.4 1.0 1 0 0 1 1 1 1 Centromere protein H (CENP-H) Cation_efflux PF01545.21 EMC86486.1 - 4.3e-47 160.4 10.5 4.3e-47 160.4 10.5 3.4 3 1 1 5 5 5 1 Cation efflux family DUF2946 PF11162.8 EMC86486.1 - 1.5 9.5 8.4 5.2 7.8 8.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2946) PI3K_P85_iSH2 PF16454.5 EMC86487.1 - 1.6e-62 209.9 21.9 2.9e-62 209.0 21.9 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain SH2 PF00017.24 EMC86487.1 - 1.1e-42 144.0 0.1 9.4e-22 76.9 0.0 2.6 2 0 0 2 2 2 2 SH2 domain RhoGAP PF00620.27 EMC86487.1 - 2.3e-31 108.7 1.7 5.1e-31 107.5 0.1 2.3 2 0 0 2 2 2 1 RhoGAP domain SH3_1 PF00018.28 EMC86487.1 - 7.7e-06 25.4 1.5 0.00059 19.4 0.1 2.8 2 0 0 2 2 2 1 SH3 domain AAA_13 PF13166.6 EMC86487.1 - 4.1e-05 22.4 13.0 6.5e-05 21.8 13.0 1.2 1 0 0 1 1 1 1 AAA domain DUF4201 PF13870.6 EMC86487.1 - 0.00044 20.0 13.2 0.0016 18.2 1.7 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4201) SH3_2 PF07653.17 EMC86487.1 - 0.0017 18.0 0.0 0.005 16.5 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EMC86487.1 - 0.0019 18.0 0.6 0.005 16.7 0.6 1.8 1 1 0 1 1 1 1 Variant SH3 domain Nucleopor_Nup85 PF07575.13 EMC86487.1 - 0.0032 16.1 0.5 0.0032 16.1 0.5 2.1 2 0 0 2 2 2 1 Nup85 Nucleoporin Laminin_I PF06008.14 EMC86487.1 - 0.005 16.6 9.6 0.0094 15.7 9.6 1.3 1 0 0 1 1 1 1 Laminin Domain I Lant_dehydr_C PF14028.6 EMC86487.1 - 0.006 16.2 0.7 0.0096 15.5 0.7 1.2 1 0 0 1 1 1 1 Lantibiotic biosynthesis dehydratase C-term Mod_r PF07200.13 EMC86487.1 - 0.017 15.2 19.1 0.47 10.6 3.0 2.6 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein PI_PP_I PF18363.1 EMC86487.1 - 0.036 14.2 2.0 0.5 10.6 2.0 2.8 1 1 0 1 1 1 0 Phosphoinositide phosphatase insertion domain Transcrip_act PF04949.13 EMC86487.1 - 0.88 9.4 14.5 0.95 9.3 7.3 3.0 1 1 2 3 3 3 0 Transcriptional activator Exonuc_VII_L PF02601.15 EMC86487.1 - 1.4 8.4 8.0 2.9 7.4 8.0 1.6 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4806 PF16064.5 EMC86487.1 - 1.5 9.2 4.5 5.8 7.3 0.9 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4806) Occludin_ELL PF07303.13 EMC86487.1 - 3.2 8.5 20.6 9.7 7.0 3.4 2.9 1 1 1 2 2 2 0 Occludin homology domain Bap31_Bap29_C PF18035.1 EMC86487.1 - 3.5 7.7 6.1 0.99 9.5 0.5 2.8 2 1 1 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF2203 PF09969.9 EMC86487.1 - 4.1 8.1 10.0 1.1 10.0 1.3 2.5 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) BRE1 PF08647.11 EMC86487.1 - 7.9 6.6 15.4 0.37 10.9 4.0 2.6 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase DUF1908 PF08926.11 EMC86489.1 - 6.6e-133 442.2 1.1 6.6e-133 442.2 1.1 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF1908) Pkinase PF00069.25 EMC86489.1 - 7.2e-62 209.1 0.0 1.3e-61 208.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC86489.1 - 9.5e-27 93.9 0.0 2.3e-26 92.6 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase PDZ_6 PF17820.1 EMC86489.1 - 6.5e-11 41.9 0.6 1.4e-10 40.8 0.1 1.9 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 EMC86489.1 - 2.9e-09 37.2 0.1 6.3e-09 36.1 0.1 1.6 1 0 0 1 1 1 1 PDZ domain APH PF01636.23 EMC86489.1 - 3.6e-06 27.1 0.1 0.03 14.3 0.0 3.1 3 1 1 4 4 4 2 Phosphotransferase enzyme family PDZ_2 PF13180.6 EMC86489.1 - 3.8e-06 27.1 0.0 9.4e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Kinase-like PF14531.6 EMC86489.1 - 0.0005 19.5 0.0 0.0017 17.8 0.0 1.8 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 EMC86489.1 - 0.017 14.7 0.1 0.041 13.5 0.1 1.6 1 0 0 1 1 1 0 RIO1 family Tricorn_PDZ PF14685.6 EMC86489.1 - 0.024 14.6 0.1 0.068 13.1 0.1 1.7 1 0 0 1 1 1 0 Tricorn protease PDZ domain Haspin_kinase PF12330.8 EMC86489.1 - 0.056 12.4 0.0 0.056 12.4 0.0 1.7 2 0 0 2 2 2 0 Haspin like kinase domain DUF4135 PF13575.6 EMC86489.1 - 0.072 12.4 0.1 0.77 9.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4135) Kdo PF06293.14 EMC86489.1 - 0.13 11.6 0.0 0.3 10.4 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family fn3 PF00041.21 EMC86490.1 - 3e-12 46.7 7.6 0.0029 17.9 0.3 5.2 4 1 0 4 4 4 4 Fibronectin type III domain IL6Ra-bind PF09240.10 EMC86490.1 - 0.051 14.0 0.1 0.051 14.0 0.1 3.1 4 0 0 4 4 4 0 Interleukin-6 receptor alpha chain, binding DUF4912 PF16258.5 EMC86490.1 - 0.1 12.8 0.0 3.9 7.7 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4912) RRM_1 PF00076.22 EMC86491.1 - 2.1e-13 49.9 0.1 3.7e-13 49.1 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMC86491.1 - 0.0062 16.1 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LRR_8 PF13855.6 EMC86492.1 - 3.6e-38 129.1 32.8 8.3e-09 35.1 1.9 7.3 4 1 5 9 9 9 8 Leucine rich repeat LRR_4 PF12799.7 EMC86492.1 - 2e-27 94.8 43.5 0.00092 19.6 2.0 9.9 3 1 7 12 12 12 11 Leucine Rich repeats (2 copies) PDZ PF00595.24 EMC86492.1 - 1.4e-13 51.0 0.1 3.8e-13 49.6 0.1 1.8 1 0 0 1 1 1 1 PDZ domain LRR_5 PF13306.6 EMC86492.1 - 4e-06 26.8 4.4 0.0081 16.1 0.2 3.9 2 1 3 5 5 5 3 BspA type Leucine rich repeat region (6 copies) PDZ_6 PF17820.1 EMC86492.1 - 7.8e-06 25.6 0.0 2e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC86492.1 - 7.2e-05 23.0 0.9 0.00084 19.6 0.0 3.2 4 0 0 4 4 4 1 PDZ domain LRR_1 PF00560.33 EMC86492.1 - 0.0098 16.3 29.5 13 6.8 0.1 11.6 10 3 0 10 10 10 1 Leucine Rich Repeat LRR_6 PF13516.6 EMC86492.1 - 0.098 12.8 20.5 13 6.1 0.1 7.9 7 0 0 7 7 7 0 Leucine Rich repeat RsmF_methylt_CI PF17126.5 EMC86492.1 - 0.15 12.1 0.4 6.7 6.8 0.0 3.8 4 0 0 4 4 4 0 RsmF rRNA methyltransferase first C-terminal domain Peptidase_M3 PF01432.20 EMC86493.1 - 8.8e-152 506.5 0.2 1.2e-151 506.0 0.2 1.2 1 0 0 1 1 1 1 Peptidase family M3 Transthyretin PF00576.21 EMC86493.1 - 0.063 14.0 0.3 1.4 9.7 0.0 2.4 2 0 0 2 2 2 0 HIUase/Transthyretin family TPR_1 PF00515.28 EMC86494.1 - 1.7e-28 97.2 10.8 1.1e-09 37.7 2.0 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EMC86494.1 - 1.3e-22 78.1 7.3 3.1e-06 26.9 1.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 EMC86494.1 - 5.7e-21 73.9 11.5 3.1e-08 33.2 1.0 4.1 2 1 2 4 4 4 3 TPR repeat TPR_8 PF13181.6 EMC86494.1 - 2.8e-19 67.6 7.2 4.8e-06 26.4 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat SGTA_dimer PF16546.5 EMC86494.1 - 1e-17 63.7 0.9 9.8e-16 57.3 0.0 3.0 3 0 0 3 3 3 1 Homodimerisation domain of SGTA TPR_17 PF13431.6 EMC86494.1 - 1.6e-15 56.3 6.1 2.5e-08 33.7 1.6 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMC86494.1 - 1.4e-14 53.0 0.6 0.00016 21.5 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 EMC86494.1 - 6.4e-11 42.7 0.4 1.4e-05 25.7 0.1 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMC86494.1 - 3.7e-10 39.8 0.1 0.039 14.8 0.0 4.0 2 1 2 4 4 3 3 Tetratricopeptide repeat TPR_9 PF13371.6 EMC86494.1 - 4e-09 36.5 0.1 3.8e-06 27.0 0.1 2.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMC86494.1 - 6.8e-09 35.9 3.5 0.00024 21.3 0.4 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMC86494.1 - 7.5e-09 36.0 1.5 3e-05 24.4 0.2 3.0 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 EMC86494.1 - 1.1e-05 25.2 6.2 0.041 13.8 0.8 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TOM20_plant PF06552.12 EMC86494.1 - 1.1e-05 25.3 2.5 0.0048 16.7 0.3 3.3 2 1 1 3 3 2 1 Plant specific mitochondrial import receptor subunit TOM20 TPR_6 PF13174.6 EMC86494.1 - 0.00021 21.7 0.8 1.5 9.6 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 EMC86494.1 - 0.00021 20.7 0.1 0.68 9.4 0.1 3.3 3 0 0 3 3 3 1 SHNi-TPR DUF627 PF04781.12 EMC86494.1 - 0.00029 20.8 0.6 0.0044 17.0 0.1 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF627) Fis1_TPR_C PF14853.6 EMC86494.1 - 0.0012 18.8 9.2 0.068 13.3 0.5 3.8 3 1 1 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 EMC86494.1 - 0.0033 17.4 9.9 0.51 10.4 0.1 4.1 4 0 0 4 4 4 2 MIT (microtubule interacting and transport) domain BTAD PF03704.17 EMC86494.1 - 0.0037 17.7 0.4 0.012 16.1 0.3 1.8 1 1 1 2 2 2 1 Bacterial transcriptional activator domain TPR_15 PF13429.6 EMC86494.1 - 0.011 14.9 0.2 4.3 6.5 0.1 2.5 1 1 2 3 3 3 0 Tetratricopeptide repeat XPC-binding PF09280.11 EMC86494.1 - 0.019 14.7 10.7 0.26 11.0 3.2 2.7 2 0 0 2 2 2 0 XPC-binding domain GerD PF17898.1 EMC86494.1 - 0.032 14.2 0.5 0.55 10.2 0.1 2.7 3 0 0 3 3 3 0 Spore germination GerD central core domain ANAPC3 PF12895.7 EMC86494.1 - 0.036 14.3 3.0 0.11 12.8 3.0 1.9 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF3856 PF12968.7 EMC86494.1 - 0.22 11.6 0.8 22 5.1 0.8 2.9 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) STI1 PF17830.1 EMC86494.1 - 1.6 8.7 8.3 0.27 11.2 2.2 2.6 2 0 0 2 2 2 0 STI1 domain DUF974 PF06159.13 EMC86495.1 - 1.8e-85 286.7 0.6 2.5e-85 286.2 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF974) Trs65 PF12735.7 EMC86495.1 - 0.00029 20.3 0.0 3 7.2 0.0 3.2 2 1 1 3 3 3 2 TRAPP trafficking subunit Trs65 Transglut_C PF00927.22 EMC86495.1 - 0.0035 17.5 0.3 0.073 13.2 0.0 3.0 2 1 1 3 3 3 1 Transglutaminase family, C-terminal ig like domain APOBEC3 PF18771.1 EMC86497.1 - 0.037 14.1 0.1 0.19 11.9 0.0 1.9 1 1 1 2 2 2 0 APOBEC3 Arf PF00025.21 EMC86498.1 - 5.8e-70 234.3 0.4 1.4e-69 233.0 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.13 EMC86498.1 - 1e-13 51.6 0.2 1.3e-12 48.0 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMC86498.1 - 1.2e-11 44.5 0.0 2.4e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EMC86498.1 - 4.5e-11 42.5 0.0 8.7e-11 41.6 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EMC86498.1 - 5.8e-10 38.9 0.1 1.9e-07 30.6 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit zf-B_box PF00643.24 EMC86498.1 - 3.3e-07 30.4 5.4 3.3e-07 30.4 5.4 3.9 4 0 0 4 4 4 2 B-box zinc finger zf-RING_UBOX PF13445.6 EMC86498.1 - 1.1e-06 28.6 5.1 1.1e-06 28.6 5.1 2.9 3 0 0 3 3 3 1 RING-type zinc-finger Gtr1_RagA PF04670.12 EMC86498.1 - 1.2e-06 28.1 0.4 2.1e-06 27.3 0.0 1.6 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region zf-RING_5 PF14634.6 EMC86498.1 - 1.7e-06 27.8 1.9 1.7e-06 27.8 1.9 4.2 3 1 0 3 3 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 EMC86498.1 - 3.4e-05 24.1 3.0 3.4e-05 24.1 3.0 4.4 5 0 0 5 5 5 1 Ring finger domain MMR_HSR1 PF01926.23 EMC86498.1 - 0.00025 21.1 0.0 0.001 19.2 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase zf-C3HC4 PF00097.25 EMC86498.1 - 0.00037 20.3 1.3 0.00037 20.3 1.3 3.7 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC86498.1 - 0.0068 16.2 3.6 0.0068 16.2 3.6 3.6 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC86498.1 - 0.007 16.2 3.2 0.007 16.2 3.2 3.2 4 0 0 4 4 3 1 Prokaryotic RING finger family 4 Thymidylate_kin PF02223.17 EMC86498.1 - 0.17 11.5 1.1 2.9 7.5 0.1 2.3 2 0 0 2 2 2 0 Thymidylate kinase Pro_isomerase PF00160.21 EMC86499.1 - 2.7e-50 170.7 0.1 4.7e-50 169.9 0.1 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 EMC86499.1 - 7.4e-11 42.4 2.0 0.071 14.0 0.0 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC86499.1 - 0.00056 20.2 0.0 1.5 9.1 0.0 3.6 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DUF505 PF04458.12 EMC86499.1 - 0.017 13.5 0.0 0.024 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF505) Ge1_WD40 PF16529.5 EMC86499.1 - 0.12 11.3 0.8 25 3.7 0.0 3.6 3 2 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Pep_M12B_propep PF01562.19 EMC86500.1 - 6.1e-41 139.9 0.3 1.1e-40 139.1 0.3 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_spacer1 PF05986.14 EMC86500.1 - 8.6e-40 135.3 0.0 2.6e-39 133.8 0.0 1.8 2 0 0 2 2 2 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 EMC86500.1 - 1.5e-18 66.7 80.7 5.3e-08 33.0 7.5 7.0 8 0 0 8 8 8 5 Thrombospondin type 1 domain ADAM_CR_2 PF17771.1 EMC86500.1 - 1.9e-18 66.7 9.4 1.9e-18 66.7 9.4 5.8 5 1 0 5 5 5 2 ADAM cysteine-rich domain Reprolysin PF01421.19 EMC86500.1 - 3.5e-14 53.2 1.7 7.3e-14 52.1 0.2 2.4 2 1 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease PLAC PF08686.11 EMC86500.1 - 1.5e-08 35.2 6.8 1.5e-08 35.2 6.8 3.2 3 0 0 3 3 3 1 PLAC (protease and lacunin) domain DAGK_cat PF00781.24 EMC86500.1 - 0.061 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Pro_isomerase PF00160.21 EMC86501.1 - 3.1e-44 151.0 0.0 6.5e-44 150.0 0.0 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-CCHC_3 PF13917.6 EMC86502.1 - 5.3e-08 32.7 0.0 7.2e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Zinc knuckle CpXC PF14353.6 EMC86502.1 - 0.026 14.6 0.2 0.033 14.2 0.2 1.1 1 0 0 1 1 1 0 CpXC protein Cytochrom_NNT PF03264.14 EMC86502.1 - 0.027 14.2 0.1 0.03 14.0 0.1 1.0 1 0 0 1 1 1 0 NapC/NirT cytochrome c family, N-terminal region zf-CCHC PF00098.23 EMC86502.1 - 0.057 13.5 2.7 0.08 13.1 2.7 1.3 1 0 0 1 1 1 0 Zinc knuckle Luteo_PO PF04662.13 EMC86502.1 - 0.11 12.1 0.0 0.14 11.8 0.0 1.0 1 0 0 1 1 1 0 Luteovirus P0 protein zf-Mss51 PF13824.6 EMC86502.1 - 0.34 11.0 2.3 1.1 9.4 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 Sad1_UNC PF07738.13 EMC86503.1 - 5.5e-34 117.0 0.0 6.3e-34 116.8 0.0 1.0 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Arf PF00025.21 EMC86504.1 - 2.1e-26 92.5 0.0 2.4e-26 92.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EMC86504.1 - 4.4e-06 26.1 0.0 5.1e-06 25.9 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Roc PF08477.13 EMC86504.1 - 0.061 13.5 0.0 0.069 13.4 0.0 1.1 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EMC86504.1 - 0.069 12.6 0.0 0.072 12.5 0.0 1.0 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Pyrophosphatase PF00719.19 EMC86505.1 - 2.1e-61 206.4 0.5 2.5e-61 206.1 0.5 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase 7tm_1 PF00001.21 EMC86506.1 - 5.6e-56 189.8 16.1 5.6e-56 189.8 16.1 1.4 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC86506.1 - 3.4e-09 36.5 13.5 6.8e-09 35.5 13.5 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC86506.1 - 5.3e-07 29.7 13.0 8.7e-07 29.0 13.0 1.4 1 1 0 1 1 1 1 Olfactory receptor PRIMA1 PF16101.5 EMC86506.1 - 0.48 10.5 2.3 11 6.1 0.7 2.4 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 LRR_8 PF13855.6 EMC86507.1 - 3e-17 62.1 2.5 1.6e-08 34.1 2.6 2.6 3 0 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 EMC86507.1 - 1.4e-13 50.7 1.4 0.00059 20.2 0.0 3.9 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC86507.1 - 2.6e-07 30.2 2.4 3.5 8.6 0.1 5.8 4 1 1 5 5 5 2 Leucine Rich Repeat LRR_9 PF14580.6 EMC86507.1 - 1e-06 28.4 4.3 0.00049 19.6 0.5 1.9 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 EMC86507.1 - 0.0001 22.1 2.2 12 6.3 0.1 5.2 5 0 0 5 5 5 1 Leucine Rich repeat eIF_4EBP PF05456.11 EMC86508.1 - 2.7e-23 82.1 0.0 2.9e-23 82.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Rab_bind PF16704.5 EMC86509.1 - 3.9e-37 126.1 9.0 3.9e-37 126.1 9.0 9.2 7 4 3 10 10 10 1 Rab binding domain GRIP PF01465.20 EMC86509.1 - 3.4e-17 62.1 0.7 1.4e-16 60.1 0.3 2.5 2 0 0 2 2 2 1 GRIP domain HOOK PF05622.12 EMC86509.1 - 8e-08 30.9 45.9 8e-08 30.9 45.9 9.2 1 1 6 7 7 7 2 HOOK protein GAS PF13851.6 EMC86509.1 - 0.00013 21.3 17.4 0.00013 21.3 17.4 15.3 2 1 13 16 16 16 7 Growth-arrest specific micro-tubule binding ZapB PF06005.12 EMC86509.1 - 0.0002 21.7 9.3 0.0002 21.7 9.3 26.0 4 4 12 17 17 17 1 Cell division protein ZapB DUF4201 PF13870.6 EMC86509.1 - 0.0024 17.6 23.1 0.0024 17.6 23.1 15.5 4 3 11 15 15 15 1 Domain of unknown function (DUF4201) TMF_TATA_bd PF12325.8 EMC86509.1 - 0.007 16.6 12.0 0.007 16.6 12.0 18.6 2 1 16 19 19 19 3 TATA element modulatory factor 1 TATA binding VWA_2 PF13519.6 EMC86509.1 - 0.26 12.0 0.0 0.26 12.0 0.0 7.1 6 1 1 7 7 7 0 von Willebrand factor type A domain Sulfotransfer_1 PF00685.27 EMC86510.1 - 1.9e-92 309.5 3.3 2.3e-92 309.3 3.3 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC86510.1 - 9.5e-09 36.0 0.2 2.6e-08 34.5 0.2 1.8 1 1 0 1 1 1 1 Sulfotransferase family SSF PF00474.17 EMC86511.1 - 3.9e-32 111.6 30.1 6e-32 111.0 30.1 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family 7tm_1 PF00001.21 EMC86512.1 - 1.6e-25 90.0 10.1 1.8e-25 89.8 10.1 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 EMC86512.1 - 6.4e-06 25.7 5.9 8.4e-06 25.3 5.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv TAS2R PF05296.13 EMC86512.1 - 0.00099 18.3 1.2 0.0012 18.1 1.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF2975 PF11188.8 EMC86512.1 - 0.0026 17.7 3.2 0.0032 17.3 3.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2975) BCD PF15461.6 EMC86512.1 - 0.0045 16.5 2.7 0.0066 16.0 2.4 1.4 1 1 0 1 1 1 1 Beta-carotene 15,15'-dioxygenase DUF1201 PF06716.11 EMC86512.1 - 2 8.5 10.8 0.22 11.6 6.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1201) 7tm_1 PF00001.21 EMC86513.1 - 2e-08 33.9 0.2 3e-08 33.3 0.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC86513.1 - 4.5e-05 23.0 2.5 5.3e-05 22.7 2.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC86513.1 - 0.00078 19.2 5.6 0.00092 18.9 5.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srd PF10317.9 EMC86513.1 - 0.044 13.0 5.3 0.05 12.8 5.3 1.0 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srd PsbN PF02468.15 EMC86513.1 - 0.46 10.4 2.0 1.1 9.1 0.2 2.1 2 0 0 2 2 2 0 Photosystem II reaction centre N protein (psbN) GDP_Man_Dehyd PF16363.5 EMC86514.1 - 1e-55 189.5 0.0 4e-55 187.5 0.0 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EMC86514.1 - 3.2e-50 170.9 0.0 4.7e-50 170.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family UXS1_N PF11803.8 EMC86514.1 - 2.8e-39 133.3 0.0 5.9e-39 132.3 0.0 1.6 1 0 0 1 1 1 1 UDP-glucuronate decarboxylase N-terminal NAD_binding_4 PF07993.12 EMC86514.1 - 2.4e-10 40.0 0.2 3.1e-06 26.5 0.0 2.6 2 1 0 3 3 3 2 Male sterility protein RmlD_sub_bind PF04321.17 EMC86514.1 - 7.1e-10 38.4 0.0 1e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 EMC86514.1 - 5.5e-09 35.4 0.0 4.5e-08 32.4 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EMC86514.1 - 2.8e-08 33.2 0.2 0.00022 20.4 0.1 2.9 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein DUF5595 PF18077.1 EMC86514.1 - 0.14 12.2 0.0 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) Augurin PF15187.6 EMC86515.1 - 1.9e-50 169.8 2.6 2.1e-50 169.7 2.6 1.0 1 0 0 1 1 1 1 Oesophageal cancer-related gene 4 DUF1700 PF08006.11 EMC86515.1 - 0.29 10.6 0.0 0.37 10.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) SH3_1 PF00018.28 EMC86516.1 - 6.8e-42 140.9 10.6 7.1e-14 51.1 0.1 4.7 5 0 0 5 5 5 3 SH3 domain SH3_9 PF14604.6 EMC86516.1 - 2.4e-39 133.0 3.8 1.7e-14 53.4 0.1 3.8 3 0 0 3 3 3 3 Variant SH3 domain SH3_2 PF07653.17 EMC86516.1 - 1e-27 95.5 7.1 1.8e-09 37.2 0.2 4.4 4 1 1 5 5 5 3 Variant SH3 domain SH2 PF00017.24 EMC86516.1 - 3.4e-22 78.3 0.0 6.7e-22 77.4 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SH3_3 PF08239.11 EMC86516.1 - 5.7e-09 36.1 10.8 0.0029 17.9 0.5 3.7 4 0 0 4 4 4 3 Bacterial SH3 domain SH3_10 PF17902.1 EMC86516.1 - 5.1e-07 29.7 3.2 0.0014 18.7 0.3 3.0 3 0 0 3 3 3 2 SH3 domain hSH3 PF14603.6 EMC86516.1 - 3e-05 24.4 0.0 0.0099 16.3 0.0 2.6 2 0 0 2 2 2 1 Helically-extended SH3 domain SH2_2 PF14633.6 EMC86516.1 - 0.0051 16.2 0.1 0.025 14.0 0.1 1.9 1 1 0 1 1 1 1 SH2 domain DUF5350 PF17299.2 EMC86516.1 - 0.15 12.5 3.3 1.4 9.4 0.2 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5350) SH3_4 PF06347.13 EMC86516.1 - 0.84 9.5 4.1 16 5.5 0.8 2.8 2 0 0 2 2 2 0 Bacterial SH3 domain LIM PF00412.22 EMC86517.1 - 3.8e-48 161.5 70.1 7e-13 48.6 7.4 5.1 5 0 0 5 5 5 5 LIM domain Sgf11 PF08209.11 EMC86517.1 - 0.16 11.6 0.3 0.16 11.6 0.3 8.9 10 0 0 10 10 10 0 Sgf11 (transcriptional regulation protein) zf-CHY PF05495.12 EMC86517.1 - 1.4 9.5 68.7 0.47 11.0 11.6 4.9 1 1 3 4 4 4 0 CHY zinc finger Ashwin PF15323.6 EMC86518.1 - 3.2e-87 292.2 7.9 3.7e-87 292.0 7.9 1.0 1 0 0 1 1 1 1 Developmental protein Vps39_2 PF10367.9 EMC86519.1 - 1.1e-30 106.2 0.1 2.8e-30 105.0 0.1 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.9 EMC86519.1 - 4.6e-27 94.4 8.9 2.6e-26 92.0 2.3 3.0 2 0 0 2 2 2 2 Vacuolar sorting protein 39 domain 1 Clathrin PF00637.20 EMC86519.1 - 1.3e-14 54.2 14.2 1.4e-09 38.0 4.8 2.5 2 0 0 2 2 2 2 Region in Clathrin and VPS CNH PF00780.22 EMC86519.1 - 5.2e-12 45.9 0.2 1.5e-11 44.5 0.1 1.8 2 0 0 2 2 2 1 CNH domain Ribosomal_S9 PF00380.19 EMC86520.1 - 1.6e-35 122.3 0.0 2.7e-35 121.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S9/S16 V-set PF07686.17 EMC86521.1 - 2e-15 56.9 0.0 2.3e-15 56.7 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC86521.1 - 3.3e-11 43.6 0.0 4.3e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC86521.1 - 2.5e-09 37.1 0.1 2e-08 34.2 0.1 1.9 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC86521.1 - 2.3e-07 30.9 0.0 5.2e-07 29.8 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC86521.1 - 9.3e-06 25.9 0.0 5.6e-05 23.4 0.0 1.9 1 1 0 1 1 1 1 Immunoglobulin domain V-set_CD47 PF08204.11 EMC86521.1 - 1.1e-05 25.4 0.0 1.4e-05 25.1 0.0 1.1 1 0 0 1 1 1 1 CD47 immunoglobulin-like domain Herpes_gE PF02480.16 EMC86521.1 - 0.054 12.2 0.0 0.062 12.0 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF3338 PF11819.8 EMC86523.1 - 1.1e-54 184.0 7.9 4.2e-54 182.2 7.9 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3338) FERM_C PF09380.10 EMC86523.1 - 5.2e-23 81.2 0.5 1.9e-22 79.5 0.5 2.0 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 EMC86523.1 - 6.8e-21 74.9 1.5 1.1e-19 71.0 0.1 2.8 2 0 0 2 2 2 1 FERM central domain FERM_N PF09379.10 EMC86523.1 - 1.7e-11 43.9 0.5 4.3e-11 42.6 0.5 1.7 1 0 0 1 1 1 1 FERM N-terminal domain Tropomodulin PF03250.14 EMC86524.1 - 1.8e-13 50.8 0.8 1.8e-13 50.8 0.8 3.0 3 1 0 3 3 3 1 Tropomodulin LRR_6 PF13516.6 EMC86524.1 - 0.00026 20.8 0.5 0.0011 18.8 0.1 2.3 2 0 0 2 2 2 1 Leucine Rich repeat Nop14 PF04147.12 EMC86524.1 - 0.0016 16.7 18.2 0.0016 16.7 18.2 1.9 2 0 0 2 2 2 1 Nop14-like family ExbD PF02472.16 EMC86524.1 - 0.0097 16.1 0.8 0.033 14.4 0.8 2.0 1 0 0 1 1 1 1 Biopolymer transport protein ExbD/TolR SDA1 PF05285.12 EMC86524.1 - 0.71 9.2 28.5 0.036 13.5 21.4 2.0 2 0 0 2 2 2 0 SDA1 PI3K_1B_p101 PF10486.9 EMC86524.1 - 2.4 5.8 10.7 3.6 5.2 10.7 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CDC45 PF02724.14 EMC86524.1 - 6.1 5.0 20.0 0.88 7.8 15.6 1.6 2 0 0 2 2 2 0 CDC45-like protein ThiF PF00899.21 EMC86525.1 - 3.8e-67 226.2 0.0 5.8e-67 225.6 0.0 1.2 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 EMC86525.1 - 1.1e-24 86.4 0.6 2e-24 85.5 0.3 1.6 2 0 0 2 2 2 1 E2 binding domain UAE_UbL PF14732.6 EMC86525.1 - 0.00081 19.9 0.0 0.0016 19.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Shikimate_DH PF01488.20 EMC86525.1 - 0.0011 19.0 0.0 0.0024 18.0 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 EMC86525.1 - 0.088 13.4 0.0 0.2 12.2 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TMF_TATA_bd PF12325.8 EMC86526.1 - 1.7e-32 112.0 11.7 1.7e-32 112.0 11.7 8.2 2 1 5 7 7 7 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 EMC86526.1 - 6e-19 67.8 25.8 6e-19 67.8 25.8 11.5 7 3 3 11 11 11 3 TATA element modulatory factor 1 DNA binding DUF1515 PF07439.11 EMC86526.1 - 0.0016 18.4 1.9 0.0016 18.4 1.9 6.3 4 1 2 7 7 7 1 Protein of unknown function (DUF1515) SlyX PF04102.12 EMC86526.1 - 0.0056 17.3 4.4 0.0056 17.3 4.4 10.5 4 3 4 9 9 9 2 SlyX DUF3800 PF12686.7 EMC86526.1 - 2.2 9.0 8.5 1.5e+03 -0.2 8.6 4.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) DUF563 PF04577.14 EMC86527.1 - 1.2e-27 97.5 0.5 1.9e-27 96.8 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) TAFA PF12020.8 EMC86528.1 - 6e-48 161.2 11.7 7.2e-48 161.0 11.7 1.1 1 0 0 1 1 1 1 TAFA family TAFA PF12020.8 EMC86529.1 - 1.3e-42 144.1 15.1 8e-42 141.6 15.1 1.8 1 1 0 1 1 1 1 TAFA family ATP-grasp_2 PF08442.10 EMC86530.1 - 7.1e-71 238.0 2.1 7.9e-71 237.8 1.2 1.5 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 EMC86530.1 - 2.2e-28 99.0 0.1 4.6e-28 98.0 0.1 1.6 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 EMC86530.1 - 7.5e-06 25.6 1.4 1.1e-05 25.0 0.4 1.7 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp PF02222.22 EMC86530.1 - 0.11 12.1 0.1 0.23 11.0 0.1 1.7 1 1 0 1 1 1 0 ATP-grasp domain MFS_1 PF07690.16 EMC86531.1 - 2.8e-43 148.2 24.6 8.4e-38 130.2 25.6 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EMC86531.1 - 1.3e-09 37.4 0.2 0.0031 16.5 0.0 4.0 2 1 1 4 4 4 3 MFS_1 like family UPF0242 PF06785.11 EMC86531.1 - 0.003 17.7 0.0 0.0077 16.4 0.0 1.7 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus DUF2371 PF10177.9 EMC86531.1 - 0.16 12.1 2.0 7.5 6.7 0.0 3.4 3 1 0 3 3 3 0 Uncharacterised conserved protein (DUF2371) BACK PF07707.15 EMC86532.1 - 1.4e-31 108.7 1.3 1.2e-30 105.6 0.4 2.3 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_1 PF01344.25 EMC86532.1 - 1.1e-29 101.7 10.7 8e-11 41.3 0.6 5.5 5 0 0 5 5 5 4 Kelch motif BTB PF00651.31 EMC86532.1 - 1.5e-28 99.2 0.3 3.5e-28 98.1 0.3 1.6 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.6 EMC86532.1 - 6.6e-22 77.0 5.9 6.3e-05 23.1 0.0 5.9 4 2 1 5 5 5 5 Kelch motif Kelch_2 PF07646.15 EMC86532.1 - 3.7e-13 48.9 5.2 4.7e-06 26.4 0.2 5.3 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 EMC86532.1 - 9.4e-11 41.6 0.5 0.0066 16.4 0.0 4.4 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_3 PF13415.6 EMC86532.1 - 8e-09 35.6 1.8 0.013 15.8 0.0 4.5 5 0 0 5 5 5 2 Galactose oxidase, central domain DUF3342 PF11822.8 EMC86532.1 - 0.007 16.5 0.9 0.047 13.9 0.0 2.7 3 1 0 3 3 3 1 Domain of unknown function (DUF3342) Kelch_5 PF13854.6 EMC86532.1 - 0.022 14.7 4.0 40 4.4 0.0 4.3 4 0 0 4 4 4 0 Kelch motif DUF4262 PF14081.6 EMC86532.1 - 0.087 13.0 0.0 0.21 11.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4262) LRR_8 PF13855.6 EMC86533.1 - 1.4e-82 271.4 64.8 8.2e-16 57.5 4.8 7.3 4 2 5 9 9 9 8 Leucine rich repeat I-set PF07679.16 EMC86533.1 - 3e-54 181.0 0.0 7.6e-22 77.2 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC86533.1 - 7e-49 164.3 0.0 4.1e-17 62.6 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain LRR_4 PF12799.7 EMC86533.1 - 4.3e-37 125.5 47.4 3.8e-05 24.0 0.0 9.0 5 2 3 9 9 9 9 Leucine Rich repeats (2 copies) Ig_2 PF13895.6 EMC86533.1 - 5.1e-35 119.7 0.0 1.2e-11 44.8 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 EMC86533.1 - 3.4e-32 110.5 0.2 4e-12 46.2 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain LRR_5 PF13306.6 EMC86533.1 - 2.1e-29 102.1 0.0 3.2e-09 36.8 0.0 4.0 1 1 3 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC86533.1 - 9.2e-18 64.3 9.0 2.3e-05 24.0 0.1 5.4 1 1 4 5 5 5 4 Leucine-rich repeat V-set PF07686.17 EMC86533.1 - 3.7e-17 62.5 3.5 0.00026 21.1 0.1 5.9 3 3 0 3 3 3 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC86533.1 - 3.2e-11 43.1 0.0 0.00053 20.0 0.0 3.8 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain LRR_1 PF00560.33 EMC86533.1 - 1.1e-09 37.5 35.5 7.9 7.5 0.1 14.3 15 0 0 15 15 15 1 Leucine Rich Repeat Ig_5 PF16681.5 EMC86533.1 - 3.3e-08 33.8 0.0 0.12 12.8 0.0 4.0 3 1 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 EMC86533.1 - 4.2e-06 26.2 0.0 1 9.0 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain Izumo-Ig PF16706.5 EMC86533.1 - 1.9e-05 24.6 1.5 0.66 10.1 0.0 4.0 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain LRRCT PF01463.24 EMC86533.1 - 0.00041 20.7 0.0 0.0018 18.7 0.0 2.2 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain C1-set PF07654.15 EMC86533.1 - 0.00049 20.4 0.1 0.071 13.5 0.0 3.3 3 0 0 3 3 3 1 Immunoglobulin C1-set domain Ig_C17orf99 PF17736.1 EMC86533.1 - 0.0018 18.3 0.0 2.9 8.0 0.0 3.2 3 0 0 3 3 3 1 C17orf99 Ig domain Ig_4 PF16680.5 EMC86533.1 - 0.0022 18.2 0.0 0.32 11.3 0.0 3.6 3 1 1 4 4 4 1 T-cell surface glycoprotein CD3 delta chain C2-set PF05790.15 EMC86533.1 - 0.039 14.1 0.0 18 5.6 0.0 3.5 3 0 0 3 3 3 0 Immunoglobulin C2-set domain Receptor_2B4 PF11465.8 EMC86533.1 - 0.041 14.1 0.0 1.4 9.2 0.0 3.0 3 0 0 3 3 3 0 Natural killer cell receptor 2B4 DUF2201 PF09967.9 EMC86533.1 - 0.056 13.6 0.0 0.17 12.0 0.0 1.8 1 0 0 1 1 1 0 VWA-like domain (DUF2201) LRR_6 PF13516.6 EMC86533.1 - 0.12 12.5 45.1 0.31 11.2 0.1 12.0 14 0 0 14 14 12 0 Leucine Rich repeat Mito_carr PF00153.27 EMC86534.1 - 3.5e-52 174.3 5.9 5.7e-21 74.2 0.4 4.0 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EMC86534.1 - 0.1 11.8 2.7 1.1 8.3 2.7 2.6 1 1 0 1 1 1 0 Gammaproteobacterial serine protease Porphobil_deamC PF03900.15 EMC86537.1 - 0.31 11.4 2.6 1.6e+02 2.8 0.0 3.8 4 0 0 4 4 4 0 Porphobilinogen deaminase, C-terminal domain Phospholip_A2_1 PF00068.19 EMC86537.1 - 1.6 9.3 11.6 64 4.1 0.2 4.0 4 0 0 4 4 4 0 Phospholipase A2 DUF2552 PF10827.8 EMC86537.1 - 3.1 8.0 9.6 1.1e+02 3.1 0.2 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2552) PAPA-1 PF04795.12 EMC86538.1 - 1.6e-06 28.8 16.5 1.6e-06 28.8 16.5 1.7 2 0 0 2 2 2 1 PAPA-1-like conserved region tRNA-synt_1c PF00749.21 EMC86538.1 - 0.25 10.2 7.2 0.31 9.9 7.2 1.0 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain PHO4 PF01384.20 EMC86539.1 - 1.9e-142 474.3 2.8 2.3e-142 474.0 2.8 1.1 1 0 0 1 1 1 1 Phosphate transporter family CKAP2_C PF15297.6 EMC86540.1 - 5.4e-35 121.1 2.7 3.7e-20 72.3 1.1 2.0 2 0 0 2 2 2 2 Cytoskeleton-associated protein 2 C-terminus ThiS PF02597.20 EMC86540.1 - 0.049 14.3 0.0 11 6.7 0.0 3.4 3 0 0 3 3 3 0 ThiS family IL1 PF00340.19 EMC86541.1 - 4.9e-20 71.4 0.0 7.3e-20 70.8 0.0 1.3 1 0 0 1 1 1 1 Interleukin-1 / 18 IL1_propep PF02394.16 EMC86541.1 - 2.2e-06 28.5 0.0 3.6e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Interleukin-1 propeptide E1_dh PF00676.20 EMC86542.1 - 1.5e-98 329.4 0.0 1.9e-98 329.1 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component 2-oxogl_dehyd_N PF16078.5 EMC86542.1 - 1.1e-19 69.8 3.9 2.4e-19 68.7 1.0 2.3 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus GGA_N-GAT PF18308.1 EMC86542.1 - 0.062 12.9 0.1 0.11 12.1 0.1 1.4 1 0 0 1 1 1 0 GGA N-GAT domain R2K_2 PF18299.1 EMC86542.1 - 0.1 12.4 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 Pro_isomerase PF00160.21 EMC86544.1 - 1.1e-45 155.8 0.1 1.2e-45 155.6 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SHIPPO-rpt PF07004.12 EMC86545.1 - 2.4e-05 25.0 30.3 0.0053 17.6 1.1 7.0 6 2 0 6 6 6 4 Sperm-tail PG-rich repeat BRICHOS PF04089.14 EMC86546.1 - 2.6e-11 43.6 0.0 3.8e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 BRICHOS domain Pro-rich PF15240.6 EMC86547.1 - 6.5 7.0 15.8 8 6.7 15.8 1.1 1 0 0 1 1 1 0 Proline-rich 7tm_1 PF00001.21 EMC86548.1 - 1.5e-47 162.2 10.1 3.1e-47 161.1 10.1 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC86548.1 - 7e-07 28.9 0.8 8.7e-07 28.6 0.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 EMC86548.1 - 5.5e-06 25.9 0.1 1.3e-05 24.7 0.0 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srx PF10328.9 EMC86548.1 - 0.022 14.4 5.1 0.045 13.4 4.3 1.9 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx DUF412 PF04217.13 EMC86548.1 - 0.11 12.4 1.8 1.3 8.9 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF412 TraL PF07178.11 EMC86548.1 - 1.4 9.4 5.1 0.31 11.5 0.7 2.2 2 0 0 2 2 2 0 TraL protein SOCS PF12610.8 EMC86551.1 - 4.4e-16 59.0 1.5 4.4e-16 59.0 1.5 1.9 2 0 0 2 2 2 1 Suppressor of cytokine signalling SOCS_box PF07525.16 EMC86551.1 - 1.3e-09 38.2 0.1 2.8e-09 37.2 0.1 1.6 1 0 0 1 1 1 1 SOCS box SH2 PF00017.24 EMC86551.1 - 4.1e-09 36.4 0.0 8.6e-09 35.4 0.0 1.6 1 0 0 1 1 1 1 SH2 domain EF-hand_6 PF13405.6 EMC86552.1 - 1.3e-09 37.2 0.3 0.00036 20.2 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 EMC86552.1 - 1.8e-08 34.7 3.6 2.1e-08 34.5 1.7 1.9 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EMC86552.1 - 3e-07 29.5 0.3 0.0007 19.0 0.2 2.9 2 1 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 EMC86552.1 - 0.00085 18.7 2.8 0.0069 15.8 0.7 2.9 2 1 1 3 3 3 1 EF hand EF-hand_8 PF13833.6 EMC86552.1 - 0.013 15.3 1.1 0.057 13.3 0.4 2.4 2 1 0 2 2 2 0 EF-hand domain pair PBECR3 PF18812.1 EMC86552.1 - 1.3 9.0 5.7 3.1 7.8 0.5 2.1 1 1 1 2 2 2 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3 Fibrinogen_C PF00147.18 EMC86553.1 - 3.2e-88 295.2 10.0 4.3e-88 294.8 10.0 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain FlaC_arch PF05377.11 EMC86553.1 - 0.0033 17.8 3.9 0.0084 16.5 1.4 2.3 2 0 0 2 2 2 1 Flagella accessory protein C (FlaC) BORCS6 PF10157.9 EMC86553.1 - 0.019 15.2 2.6 0.038 14.2 2.6 1.5 1 1 0 1 1 1 0 BLOC-1-related complex sub-unit 6 NBP1 PF08537.10 EMC86553.1 - 0.13 11.6 6.3 0.27 10.6 6.3 1.4 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 MutS_II PF05188.17 EMC86553.1 - 0.14 12.5 0.5 0.34 11.2 0.2 1.8 2 0 0 2 2 2 0 MutS domain II Jnk-SapK_ap_N PF09744.9 EMC86553.1 - 0.16 12.2 6.4 0.27 11.4 6.4 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF1664 PF07889.12 EMC86553.1 - 0.17 11.9 1.9 0.85 9.7 0.7 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.15 EMC86553.1 - 0.17 11.4 2.5 0.27 10.8 2.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Prefoldin PF02996.17 EMC86553.1 - 0.19 11.7 5.7 4.7 7.2 0.3 2.4 2 0 0 2 2 2 0 Prefoldin subunit Laminin_II PF06009.12 EMC86553.1 - 0.28 11.2 7.1 0.18 11.8 3.5 2.0 2 0 0 2 2 2 0 Laminin Domain II YscO PF07321.12 EMC86553.1 - 0.3 11.0 4.1 2 8.4 0.4 2.2 2 0 0 2 2 2 0 Type III secretion protein YscO Uds1 PF15456.6 EMC86553.1 - 0.31 11.2 5.0 0.62 10.2 5.0 1.4 1 0 0 1 1 1 0 Up-regulated During Septation Med9 PF07544.13 EMC86553.1 - 0.37 10.9 3.6 0.4 10.8 0.2 2.2 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 EMP24_GP25L PF01105.24 EMC86553.1 - 2 8.3 4.7 2.8 7.8 3.1 2.0 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD SOGA PF11365.8 EMC86553.1 - 2 9.6 6.2 10 7.3 6.2 2.1 1 1 0 1 1 1 0 Protein SOGA LPP PF04728.13 EMC86553.1 - 3.7 8.0 6.2 8.2 6.9 0.5 2.7 3 0 0 3 3 2 0 Lipoprotein leucine-zipper XhlA PF10779.9 EMC86553.1 - 4.9 7.4 7.3 0.5 10.6 1.9 2.1 2 0 0 2 2 2 0 Haemolysin XhlA Csm1_N PF18504.1 EMC86553.1 - 5.3 7.5 9.0 6.6 7.1 1.6 2.6 2 0 0 2 2 2 0 Csm1 N-terminal domain PRKG1_interact PF15898.5 EMC86553.1 - 9.6 7.2 9.1 41 5.1 8.8 2.1 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF4097 PF13349.6 EMC86554.1 - 6.9e-08 32.2 18.0 1.4e-07 31.2 12.9 2.6 1 1 1 2 2 2 1 Putative adhesin CBF_beta PF02312.17 EMC86554.1 - 0.029 14.0 1.0 2.3 7.8 0.1 2.9 2 1 1 3 3 3 0 Core binding factor beta subunit Proteasom_Rpn13 PF04683.13 EMC86554.1 - 0.046 14.3 0.1 14 6.3 0.0 3.5 1 1 1 3 3 3 0 Proteasome complex subunit Rpn13 ubiquitin receptor HtaA PF04213.13 EMC86554.1 - 0.047 14.2 1.0 0.12 12.9 1.0 1.6 1 0 0 1 1 1 0 Htaa LRR_6 PF13516.6 EMC86555.1 - 6.2e-30 100.7 19.6 0.0065 16.4 0.0 14.2 15 0 0 15 15 15 7 Leucine Rich repeat LRR_4 PF12799.7 EMC86555.1 - 4.2e-16 58.8 15.1 0.0088 16.4 0.0 8.6 4 3 6 10 10 10 8 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EMC86555.1 - 1.8e-07 30.9 1.6 5.2e-07 29.5 1.6 1.9 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.33 EMC86555.1 - 4.5e-07 29.5 25.2 6.7 7.7 0.0 11.3 10 3 0 10 10 10 2 Leucine Rich Repeat LRR_8 PF13855.6 EMC86555.1 - 5.3e-06 26.1 12.7 0.02 14.7 0.0 5.7 6 1 1 7 7 7 3 Leucine rich repeat F-box PF00646.33 EMC86555.1 - 9.3e-05 22.2 1.8 0.0002 21.2 0.3 2.4 2 0 0 2 2 2 1 F-box domain SAM_Ste50p PF09235.10 EMC86555.1 - 0.002 18.3 6.8 11 6.3 0.1 6.0 5 2 0 5 5 5 1 Ste50p, sterile alpha motif Arm_2 PF04826.13 EMC86556.1 - 6.1e-70 235.6 7.2 6.7e-70 235.4 7.2 1.0 1 0 0 1 1 1 1 Armadillo-like Arm PF00514.23 EMC86556.1 - 9.1e-10 38.2 1.5 0.0013 18.7 0.1 3.5 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 EMC86556.1 - 0.0003 20.9 0.9 0.0035 17.4 0.9 2.0 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EMC86556.1 - 0.0012 19.2 0.2 3.7 8.0 0.0 2.9 2 1 0 2 2 2 2 HEAT repeats UME PF08064.13 EMC86556.1 - 0.0017 18.2 0.4 0.46 10.4 0.1 2.4 1 1 1 2 2 2 2 UME (NUC010) domain HEAT PF02985.22 EMC86556.1 - 0.0023 18.0 0.1 0.12 12.7 0.0 3.0 3 0 0 3 3 3 1 HEAT repeat Atx10homo_assoc PF09759.9 EMC86556.1 - 0.052 13.6 1.2 0.4 10.7 0.5 2.4 1 1 1 2 2 2 0 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.6 EMC86556.1 - 0.057 13.9 0.7 22 5.7 0.0 3.0 3 1 1 4 4 4 0 HEAT-like repeat DUF3361 PF11841.8 EMC86556.1 - 0.18 11.7 4.1 0.41 10.6 0.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3361) Lactamase_B_2 PF12706.7 EMC86557.1 - 5.4e-39 133.8 0.0 7.9e-39 133.3 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EMC86557.1 - 2e-13 50.6 0.0 2.9e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EMC86557.1 - 0.01 15.8 0.0 0.037 14.0 0.0 1.9 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily RAC_head PF16717.5 EMC86558.1 - 6.7e-23 81.5 9.0 6.7e-23 81.5 9.0 4.3 5 2 0 5 5 5 1 Ribosome-associated complex head domain Myb_DNA-binding PF00249.31 EMC86558.1 - 2.3e-20 72.5 0.2 1.4e-11 44.4 0.1 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain DnaJ PF00226.31 EMC86558.1 - 3.1e-15 56.0 0.1 3.1e-15 56.0 0.1 2.8 2 0 0 2 2 2 1 DnaJ domain Myb_DNA-bind_6 PF13921.6 EMC86558.1 - 3.4e-10 40.0 1.2 7e-06 26.2 0.1 3.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain GHBP PF12772.7 EMC86558.1 - 0.8 9.2 16.3 0.29 10.6 12.3 2.5 1 1 1 2 2 2 0 Growth hormone receptor binding AAA PF00004.29 EMC86559.1 - 1.4e-40 138.8 0.0 5.7e-40 136.8 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMC86559.1 - 7.6e-09 35.2 0.1 1.7e-08 34.1 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EMC86559.1 - 4.9e-05 23.6 0.0 0.0054 17.0 0.0 2.7 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EMC86559.1 - 0.00039 20.4 0.1 0.0021 18.1 0.1 2.4 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EMC86559.1 - 0.0013 19.1 0.1 0.027 14.9 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 EMC86559.1 - 0.0035 17.5 0.0 0.011 15.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 EMC86559.1 - 0.0036 16.5 0.0 0.011 14.9 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EMC86559.1 - 0.0071 16.1 0.0 0.019 14.7 0.0 1.6 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EMC86559.1 - 0.012 15.8 0.0 0.023 14.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EMC86559.1 - 0.013 15.7 0.0 0.023 14.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EMC86559.1 - 0.017 15.6 0.0 0.048 14.2 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_7 PF12775.7 EMC86559.1 - 0.019 14.5 0.0 0.045 13.3 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activ_2 PF14532.6 EMC86559.1 - 0.058 13.5 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 EMC86559.1 - 0.06 12.7 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EMC86559.1 - 0.071 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 EMC86559.1 - 0.073 12.8 0.3 0.64 9.7 0.0 2.5 3 1 0 3 3 2 0 AAA domain TIP49 PF06068.13 EMC86559.1 - 0.074 12.3 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain RNA_helicase PF00910.22 EMC86559.1 - 0.089 13.2 0.0 0.29 11.5 0.0 1.9 2 0 0 2 2 1 0 RNA helicase AAA_3 PF07726.11 EMC86559.1 - 0.12 12.2 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EMC86559.1 - 0.15 12.1 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EMC86559.1 - 0.16 11.7 0.0 0.42 10.3 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain Sulfate_transp PF00916.20 EMC86560.1 - 6.9e-118 393.7 27.1 9.4e-118 393.3 27.1 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EMC86560.1 - 1e-26 92.8 0.1 2e-26 91.9 0.1 1.5 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EMC86560.1 - 2.6 8.5 22.7 0.065 13.6 6.1 3.9 2 1 0 3 3 3 0 Molybdate transporter of MFS superfamily ORC5_C PF14630.6 EMC86561.1 - 2.3e-66 224.2 0.1 3.3e-66 223.7 0.1 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 EMC86561.1 - 2.2e-15 57.4 0.1 4.2e-15 56.5 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EMC86561.1 - 3.3e-09 37.1 0.2 1.9e-08 34.6 0.1 2.0 2 0 0 2 2 2 1 AAA domain Kinesin PF00225.23 EMC86561.1 - 0.0042 16.1 0.9 0.011 14.7 0.6 1.6 1 1 0 1 1 1 1 Kinesin motor domain ATPase_2 PF01637.18 EMC86561.1 - 0.0097 15.8 0.0 0.021 14.7 0.0 1.6 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea Microtub_bd PF16796.5 EMC86561.1 - 0.011 15.7 0.0 0.023 14.6 0.0 1.6 1 0 0 1 1 1 0 Microtubule binding AAA_24 PF13479.6 EMC86561.1 - 0.017 14.9 0.0 0.029 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain PIF1 PF05970.14 EMC86561.1 - 0.05 12.8 0.0 0.14 11.3 0.0 1.6 2 0 0 2 2 2 0 PIF1-like helicase AAA_14 PF13173.6 EMC86561.1 - 0.051 13.6 0.4 0.39 10.8 0.4 2.2 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 EMC86561.1 - 0.1 13.0 0.0 0.31 11.5 0.0 1.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EMC86561.1 - 0.13 11.8 0.0 0.26 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Pkinase PF00069.25 EMC86563.1 - 3.5e-35 121.6 5.9 4.2e-22 78.8 0.2 2.5 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMC86563.1 - 1e-12 47.9 0.1 5.2e-09 35.8 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC86563.1 - 0.0063 15.3 0.2 0.0063 15.3 0.2 2.1 1 1 0 2 2 2 1 Fungal protein kinase TruD PF01142.18 EMC86564.1 - 4e-71 240.0 0.0 1.3e-65 221.8 0.0 2.5 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) RINT1_TIP1 PF04437.13 EMC86565.1 - 1.2e-131 440.1 11.0 1.2e-131 440.1 11.0 1.9 2 0 0 2 2 2 1 RINT-1 / TIP-1 family DUF948 PF06103.11 EMC86565.1 - 0.22 11.8 1.0 2.2 8.6 0.4 2.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Phasin PF05597.11 EMC86565.1 - 3.7 7.6 5.7 1.7 8.7 1.1 2.6 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) EF-hand_6 PF13405.6 EMC86566.1 - 0.051 13.5 0.0 0.098 12.6 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain SCA7 PF08313.12 EMC86567.1 - 3.8e-28 97.2 4.1 6.8e-28 96.4 2.3 2.3 2 0 0 2 2 2 1 SCA7, zinc-binding domain Sua5_yciO_yrdC PF01300.18 EMC86567.1 - 0.047 13.2 0.8 0.11 12.0 0.8 1.6 1 0 0 1 1 1 0 Telomere recombination OrsD PF12013.8 EMC86567.1 - 0.052 14.0 0.6 0.2 12.1 0.6 2.0 1 0 0 1 1 1 0 Orsellinic acid/F9775 biosynthesis cluster protein D MARVEL PF01284.23 EMC86568.1 - 2e-35 121.9 14.0 2.6e-35 121.6 14.0 1.1 1 0 0 1 1 1 1 Membrane-associating domain NAPRTase PF04095.16 EMC86569.1 - 1e-72 244.6 0.0 1.4e-72 244.2 0.0 1.2 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family DUF5598 PF18127.1 EMC86569.1 - 3.5e-36 123.6 2.3 3.5e-36 123.6 2.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF5598) PI3Ka PF00613.20 EMC86570.1 - 2.5e-63 212.9 1.5 2.5e-63 212.9 1.5 1.9 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EMC86570.1 - 2.2e-56 191.4 0.7 2.2e-56 191.4 0.7 2.2 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3K_rbd PF00794.18 EMC86570.1 - 1.9e-27 95.5 5.7 2.9e-26 91.7 0.0 3.6 4 0 0 4 4 4 1 PI3-kinase family, ras-binding domain PI3K_C2 PF00792.24 EMC86570.1 - 9e-16 58.1 0.1 2.8e-15 56.5 0.1 1.8 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 DUF4135 PF13575.6 EMC86570.1 - 0.0037 16.6 0.0 0.0067 15.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) BMFP PF04380.13 EMC86570.1 - 0.14 12.7 0.3 0.88 10.1 0.1 2.4 2 0 0 2 2 2 0 Membrane fusogenic activity cNMP_binding PF00027.29 EMC86571.1 - 5.5e-39 132.1 0.1 1.5e-21 76.2 0.0 2.2 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain DUF627 PF04781.12 EMC86571.1 - 0.16 12.0 0.0 0.26 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF627) AXH PF08517.12 EMC86572.1 - 6.7e-35 120.1 0.0 1.2e-34 119.3 0.0 1.5 1 0 0 1 1 1 1 Ataxin-1 and HBP1 module (AXH) HMG_box PF00505.19 EMC86572.1 - 6.4e-15 55.3 0.9 1.3e-14 54.4 0.9 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC86572.1 - 2.6e-09 37.5 1.6 5.3e-09 36.6 1.6 1.5 1 0 0 1 1 1 1 HMG-box domain MATalpha_HMGbox PF04769.12 EMC86572.1 - 0.0026 17.1 0.1 0.0045 16.3 0.1 1.3 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 HMG-box Peptidase_S64 PF08192.11 EMC86572.1 - 0.12 10.8 0.9 0.17 10.3 0.9 1.2 1 0 0 1 1 1 0 Peptidase family S64 COG5 PF10392.9 EMC86573.1 - 3.4e-31 108.2 2.2 3.4e-31 108.2 2.2 2.9 3 0 0 3 3 3 1 Golgi transport complex subunit 5 Vps51 PF08700.11 EMC86573.1 - 1.1e-09 38.3 3.3 2.8e-09 36.9 0.3 3.3 2 1 1 3 3 3 1 Vps51/Vps67 COG2 PF06148.11 EMC86573.1 - 0.00032 20.8 0.5 0.00032 20.8 0.5 4.1 4 1 0 4 4 4 1 COG (conserved oligomeric Golgi) complex component, COG2 FapA PF03961.13 EMC86573.1 - 0.07 11.7 0.4 0.19 10.3 0.0 1.8 2 0 0 2 2 2 0 Flagellar Assembly Protein A Fib_alpha PF08702.10 EMC86573.1 - 0.12 12.5 2.3 3.5 7.8 0.3 3.6 3 1 0 3 3 3 0 Fibrinogen alpha/beta chain family Vps54_N PF10475.9 EMC86573.1 - 0.45 9.7 5.6 0.11 11.7 1.0 2.1 2 0 0 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex DLP_helical PF18709.1 EMC86573.1 - 0.62 9.2 4.5 0.26 10.5 0.1 2.5 3 0 0 3 3 3 0 Dynamin-like helical domain Fzo_mitofusin PF04799.13 EMC86573.1 - 7 6.2 7.7 4.3 6.8 0.1 3.6 4 1 0 4 4 4 0 fzo-like conserved region 7tm_1 PF00001.21 EMC86574.1 - 1.8e-25 89.8 21.9 2.3e-25 89.4 21.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1980 PF09323.10 EMC86574.1 - 1.8 8.5 11.9 1.4 8.8 0.7 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF1980) Dus PF01207.17 EMC86575.1 - 6.8e-75 252.0 0.2 8.4e-75 251.7 0.2 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 EMC86575.1 - 5.3e-06 26.1 0.4 0.0032 16.9 0.0 1.5 1 1 1 2 2 2 2 Histidine biosynthesis protein TMP-TENI PF02581.17 EMC86575.1 - 0.0038 16.6 0.0 0.0072 15.7 0.0 1.5 1 0 0 1 1 1 1 Thiamine monophosphate synthase Oxidored_FMN PF00724.20 EMC86575.1 - 0.029 13.6 0.0 0.048 12.9 0.0 1.4 1 1 0 1 1 1 0 NADH:flavin oxidoreductase / NADH oxidase family ThiG PF05690.14 EMC86575.1 - 0.071 12.4 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG Bap31 PF05529.12 EMC86576.1 - 3.4e-28 98.2 5.1 3.4e-28 98.2 5.1 1.6 2 0 0 2 2 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 EMC86576.1 - 1.1e-12 47.7 6.1 1.1e-12 47.7 6.1 2.5 2 0 0 2 2 2 1 Bap31/Bap29 cytoplasmic coiled-coil domain Cluap1 PF10234.9 EMC86576.1 - 0.0018 17.7 9.4 0.0022 17.4 9.4 1.2 1 0 0 1 1 1 1 Clusterin-associated protein-1 MscS_porin PF12795.7 EMC86576.1 - 0.0019 17.8 6.4 0.0019 17.8 6.4 1.4 2 0 0 2 2 1 1 Mechanosensitive ion channel porin domain APC_N_CC PF16689.5 EMC86576.1 - 0.0039 17.2 5.0 0.11 12.5 2.0 2.8 2 1 1 3 3 3 1 Coiled-coil N-terminus of APC, dimerisation domain MAD PF05557.13 EMC86576.1 - 0.0059 15.0 13.4 0.0091 14.4 13.4 1.3 1 0 0 1 1 1 1 Mitotic checkpoint protein Sec34 PF04136.15 EMC86576.1 - 0.01 15.7 9.7 0.034 14.0 1.8 2.7 3 0 0 3 3 3 0 Sec34-like family ADIP PF11559.8 EMC86576.1 - 0.013 15.5 11.5 0.013 15.5 11.5 1.5 2 0 0 2 2 1 0 Afadin- and alpha -actinin-Binding T3SS_HrpK1 PF16937.5 EMC86576.1 - 0.018 14.7 0.9 0.024 14.3 0.9 1.2 1 0 0 1 1 1 0 Type III secretion system translocator protein, HrpF DUF4085 PF13315.6 EMC86576.1 - 0.02 14.6 6.8 0.029 14.0 6.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) CENP-H PF05837.12 EMC86576.1 - 0.021 15.3 14.0 0.04 14.3 8.9 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Fez1 PF06818.15 EMC86576.1 - 0.036 14.5 12.6 0.062 13.8 12.6 1.3 1 0 0 1 1 1 0 Fez1 Atg14 PF10186.9 EMC86576.1 - 0.041 13.0 5.5 0.055 12.6 5.5 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 APG6_N PF17675.1 EMC86576.1 - 0.043 14.4 16.6 0.039 14.5 15.1 1.7 2 0 0 2 2 2 0 Apg6 coiled-coil region Cep57_MT_bd PF06657.13 EMC86576.1 - 0.1 13.1 11.9 0.18 12.3 8.0 2.7 2 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 End3 PF12761.7 EMC86576.1 - 0.1 12.8 9.6 0.15 12.2 9.6 1.3 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 Spc7 PF08317.11 EMC86576.1 - 0.1 11.4 10.9 0.17 10.7 10.9 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein HemX PF04375.14 EMC86576.1 - 0.19 11.0 10.1 0.29 10.4 1.1 2.0 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Ycf54 PF10674.9 EMC86576.1 - 0.24 11.7 2.6 0.21 11.9 0.9 1.7 2 0 0 2 2 1 0 Protein of unknown function (DUF2488) UPF0242 PF06785.11 EMC86576.1 - 0.25 11.4 15.2 2 8.5 11.1 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF3450 PF11932.8 EMC86576.1 - 0.27 10.5 8.4 0.47 9.7 8.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) PLAC9 PF15205.6 EMC86576.1 - 0.3 11.5 1.2 0.74 10.3 0.4 2.1 2 0 0 2 2 1 0 Placenta-specific protein 9 Syntaxin_2 PF14523.6 EMC86576.1 - 0.41 11.1 10.1 0.2 12.0 6.3 2.2 2 1 1 3 3 2 0 Syntaxin-like protein JAKMIP_CC3 PF16034.5 EMC86576.1 - 0.47 10.4 11.7 1.3 9.0 11.6 1.8 1 1 0 1 1 1 0 JAKMIP CC3 domain AATF-Che1 PF13339.6 EMC86576.1 - 0.54 10.9 8.6 0.26 12.0 6.2 1.7 2 0 0 2 2 1 0 Apoptosis antagonizing transcription factor MPS2 PF17060.5 EMC86576.1 - 0.62 9.3 11.9 0.024 13.9 5.9 1.6 2 0 0 2 2 2 0 Monopolar spindle protein 2 HALZ PF02183.18 EMC86576.1 - 0.64 10.3 11.1 1.7 8.9 0.3 3.3 3 0 0 3 3 3 0 Homeobox associated leucine zipper LPP PF04728.13 EMC86576.1 - 0.72 10.3 5.0 0.62 10.5 0.6 2.6 2 0 0 2 2 2 0 Lipoprotein leucine-zipper DHR10 PF18595.1 EMC86576.1 - 0.88 9.7 18.9 1.2 9.3 6.4 2.8 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain HIP1_clath_bdg PF16515.5 EMC86576.1 - 1.4 9.6 14.0 0.46 11.1 10.7 1.9 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 YabA PF06156.13 EMC86576.1 - 1.5 9.5 15.5 3.9 8.2 3.5 2.9 2 1 1 3 3 3 0 Initiation control protein YabA Uds1 PF15456.6 EMC86576.1 - 2.3 8.4 13.8 5.5 7.2 12.6 2.2 1 1 1 2 2 2 0 Up-regulated During Septation BST2 PF16716.5 EMC86576.1 - 3.1 8.5 11.3 0.73 10.5 7.1 2.1 2 1 0 2 2 1 0 Bone marrow stromal antigen 2 Cep57_CLD_2 PF14197.6 EMC86576.1 - 3.7 7.7 11.9 5.8 7.1 1.4 3.3 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 UPF0449 PF15136.6 EMC86576.1 - 4 8.0 11.2 0.27 11.7 3.0 2.7 2 1 1 3 3 2 0 Uncharacterised protein family UPF0449 THOC7 PF05615.13 EMC86576.1 - 4.2 7.7 12.9 28 5.0 12.9 2.2 1 1 0 1 1 1 0 Tho complex subunit 7 DUF1664 PF07889.12 EMC86576.1 - 4.7 7.3 8.7 0.56 10.3 1.6 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) ZapB PF06005.12 EMC86576.1 - 6.1 7.4 17.5 4.7e+02 1.3 15.8 3.2 2 1 0 2 2 2 0 Cell division protein ZapB DivIVA PF05103.13 EMC86576.1 - 6.2 6.9 16.3 0.54 10.4 11.7 1.6 2 0 0 2 2 1 0 DivIVA protein Nup54_57_C PF18570.1 EMC86576.1 - 9.6 5.9 9.7 5.8 6.6 2.5 2.7 2 1 1 3 3 3 0 NUP57/Nup54 C-terminal domain Sulfate_transp PF00916.20 EMC86577.1 - 3e-103 345.5 25.6 3.8e-103 345.2 25.6 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EMC86577.1 - 4.6e-33 113.3 0.4 1e-32 112.2 0.4 1.6 1 0 0 1 1 1 1 STAS domain 7tm_6 PF02949.20 EMC86577.1 - 0.24 10.4 2.4 5.5 6.0 0.2 2.5 2 0 0 2 2 2 0 7tm Odorant receptor zf_Hakai PF18408.1 EMC86578.1 - 2.6e-21 75.0 2.3 5e-21 74.1 2.3 1.5 1 0 0 1 1 1 1 C2H2 Hakai zinc finger domain zf-C3HC4_3 PF13920.6 EMC86578.1 - 2.5e-05 24.0 7.9 5.3e-05 23.0 7.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC86578.1 - 0.0013 18.7 7.5 0.0028 17.6 7.5 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EMC86578.1 - 0.0013 18.6 8.7 0.0027 17.5 8.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC86578.1 - 0.0016 18.3 9.6 0.0066 16.3 9.6 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC86578.1 - 0.02 14.7 6.5 0.043 13.7 6.5 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DZR PF12773.7 EMC86578.1 - 0.044 13.8 7.2 0.21 11.6 6.9 2.1 1 1 0 1 1 1 0 Double zinc ribbon zinc-ribbons_6 PF07191.12 EMC86578.1 - 0.054 13.5 10.4 0.1 12.6 10.4 1.4 1 0 0 1 1 1 0 zinc-ribbons zf-RING_2 PF13639.6 EMC86578.1 - 0.07 13.5 8.5 0.17 12.3 8.5 1.7 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.6 EMC86578.1 - 0.11 12.5 6.8 0.38 10.8 6.8 2.0 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_4 PF14570.6 EMC86578.1 - 0.78 9.6 8.1 0.1 12.4 3.7 1.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-MIZ PF02891.20 EMC86578.1 - 0.81 9.5 5.6 1.9 8.3 5.6 1.6 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger C1_4 PF07975.12 EMC86578.1 - 5.7 7.3 10.0 7.1 7.0 8.5 2.0 2 1 0 2 2 2 0 TFIIH C1-like domain Sulfate_transp PF00916.20 EMC86579.1 - 7.1e-112 373.9 21.6 9.4e-112 373.5 21.6 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EMC86579.1 - 2.5e-33 114.2 0.1 4.5e-33 113.3 0.1 1.5 1 0 0 1 1 1 1 STAS domain Pyr_redox_2 PF07992.14 EMC86580.1 - 1.4e-66 224.8 7.3 1.4e-66 224.8 7.3 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EMC86580.1 - 8.5e-41 138.7 0.2 8.5e-41 138.7 0.2 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EMC86580.1 - 3.3e-18 66.0 6.5 9.2e-17 61.4 1.3 3.0 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMC86580.1 - 3.5e-10 39.6 3.1 4.6e-07 29.4 0.2 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EMC86580.1 - 2.8e-09 36.8 9.0 3.1e-09 36.7 0.0 2.9 2 1 1 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMC86580.1 - 5.1e-09 35.7 3.8 5.5e-07 29.0 0.3 3.1 3 0 0 3 3 3 2 FAD binding domain GIDA PF01134.22 EMC86580.1 - 2.2e-06 27.0 10.6 4.9e-06 25.9 4.7 2.9 2 1 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EMC86580.1 - 1.5e-05 25.1 7.8 7.8e-05 22.8 0.1 2.7 3 0 0 3 3 2 2 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 EMC86580.1 - 0.00017 21.0 8.6 0.033 13.5 0.9 3.1 3 0 0 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 EMC86580.1 - 0.00017 21.0 5.1 0.0074 15.6 0.2 3.4 3 1 0 3 3 3 1 FAD binding domain HI0933_like PF03486.14 EMC86580.1 - 0.00019 20.2 11.4 0.0014 17.5 0.5 3.7 4 0 0 4 4 4 2 HI0933-like protein K_oxygenase PF13434.6 EMC86580.1 - 0.00032 20.0 1.5 0.5 9.5 0.3 2.6 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EMC86580.1 - 0.00046 19.5 0.7 0.0012 18.1 0.0 2.0 2 0 0 2 2 2 1 Thi4 family UDPG_MGDP_dh_N PF03721.14 EMC86580.1 - 0.019 14.5 7.9 1.1 8.8 0.2 3.5 4 0 0 4 4 4 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UPF0227 PF05728.12 EMC86580.1 - 0.081 12.9 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) 3HCDH_N PF02737.18 EMC86580.1 - 0.19 11.6 5.8 1.2 8.9 1.2 2.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DAO PF01266.24 EMC86580.1 - 0.25 10.9 11.7 3.9 7.0 0.1 3.9 4 0 0 4 4 4 0 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.19 EMC86580.1 - 2.2 7.6 5.7 2.7 7.3 0.2 3.1 4 0 0 4 4 4 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Laminin_EGF PF00053.24 EMC86581.1 - 9.2e-122 397.1 237.8 5.3e-14 52.1 5.6 13.7 11 2 2 13 13 13 13 Laminin EGF domain Laminin_N PF00055.17 EMC86581.1 - 8.8e-67 225.1 0.0 5.1e-66 222.6 0.0 2.4 1 0 0 1 1 1 1 Laminin N-terminal (Domain VI) F5_F8_type_C PF00754.25 EMC86581.1 - 0.021 14.9 0.0 0.051 13.7 0.0 1.6 1 0 0 1 1 1 0 F5/8 type C domain COPIIcoated_ERV PF07970.12 EMC86582.1 - 6.5e-50 170.0 0.3 9.6e-50 169.5 0.3 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EMC86582.1 - 1e-24 86.6 0.3 2.4e-24 85.5 0.3 1.6 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Pkinase PF00069.25 EMC86583.1 - 3e-41 141.5 0.0 9.9e-41 139.8 0.0 1.8 2 0 0 2 2 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC86583.1 - 6.3e-40 137.1 0.0 1.6e-39 135.8 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase Roc PF08477.13 EMC86583.1 - 7.3e-31 106.9 0.0 2.1e-30 105.4 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase COR PF16095.5 EMC86583.1 - 7.5e-27 94.4 0.5 3.1e-25 89.1 0.3 2.6 2 0 0 2 2 2 1 C-terminal of Roc, COR, domain LRR_8 PF13855.6 EMC86583.1 - 1.7e-25 88.5 36.8 2.5e-07 30.3 1.4 7.1 6 1 0 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EMC86583.1 - 2.4e-18 65.9 48.0 5.8e-07 29.7 0.2 8.6 2 1 6 9 9 9 8 Leucine Rich repeats (2 copies) Ras PF00071.22 EMC86583.1 - 7.3e-15 54.9 0.0 2.1e-14 53.4 0.0 1.8 1 0 0 1 1 1 1 Ras family Arf PF00025.21 EMC86583.1 - 2.8e-07 30.2 0.8 7.2e-07 28.8 0.1 2.0 2 0 0 2 2 2 1 ADP-ribosylation factor family Ank_2 PF12796.7 EMC86583.1 - 1.4e-05 25.5 0.7 0.0001 22.8 0.3 2.7 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) LRR_9 PF14580.6 EMC86583.1 - 7.2e-05 22.4 11.1 0.0081 15.7 1.4 3.7 1 1 3 4 4 4 1 Leucine-rich repeat Gtr1_RagA PF04670.12 EMC86583.1 - 0.00021 20.7 0.0 0.00053 19.4 0.0 1.7 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region NB-ARC PF00931.22 EMC86583.1 - 0.0088 15.3 0.4 0.044 13.0 0.4 2.1 1 1 0 1 1 1 1 NB-ARC domain T2SSE PF00437.20 EMC86583.1 - 0.011 14.8 0.0 0.026 13.6 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.27 EMC86583.1 - 0.013 16.0 0.2 0.041 14.4 0.2 1.8 1 0 0 1 1 1 0 ABC transporter Arm PF00514.23 EMC86583.1 - 0.016 15.2 1.7 0.39 10.8 0.1 3.9 4 0 0 4 4 3 0 Armadillo/beta-catenin-like repeat TrwB_AAD_bind PF10412.9 EMC86583.1 - 0.017 14.0 0.2 0.056 12.3 0.1 1.9 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain MMR_HSR1 PF01926.23 EMC86583.1 - 0.017 15.2 0.0 0.047 13.8 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase PduV-EutP PF10662.9 EMC86583.1 - 0.02 14.7 0.4 0.052 13.3 0.4 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation G-alpha PF00503.20 EMC86583.1 - 0.02 14.0 0.3 0.067 12.3 0.0 1.9 2 0 0 2 2 2 0 G-protein alpha subunit Ank_4 PF13637.6 EMC86583.1 - 0.032 14.8 0.2 0.5 11.0 0.0 3.3 3 0 0 3 3 2 0 Ankyrin repeats (many copies) AAA_7 PF12775.7 EMC86583.1 - 0.034 13.7 0.0 0.072 12.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region THOC2_N PF16134.5 EMC86583.1 - 0.037 12.7 0.1 0.069 11.8 0.1 1.3 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus cobW PF02492.19 EMC86583.1 - 0.041 13.5 0.4 0.085 12.4 0.4 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain FtsK_SpoIIIE PF01580.18 EMC86583.1 - 0.042 13.2 0.0 0.093 12.1 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_22 PF13401.6 EMC86583.1 - 0.045 14.0 0.1 0.25 11.6 0.0 2.3 2 0 0 2 2 1 0 AAA domain Septin PF00735.18 EMC86583.1 - 0.047 13.0 0.0 0.092 12.0 0.0 1.4 1 0 0 1 1 1 0 Septin NACHT PF05729.12 EMC86583.1 - 0.053 13.4 2.0 0.093 12.6 0.4 2.2 2 0 0 2 2 2 0 NACHT domain Kdo PF06293.14 EMC86583.1 - 0.063 12.6 0.1 0.16 11.3 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family AAA_16 PF13191.6 EMC86583.1 - 0.069 13.5 0.0 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EMC86583.1 - 0.081 12.7 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 EMC86583.1 - 0.099 12.8 0.0 0.26 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EMC86583.1 - 0.12 11.7 0.0 0.27 10.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein MobB PF03205.14 EMC86583.1 - 0.12 12.2 0.2 0.31 10.9 0.2 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B TsaE PF02367.17 EMC86583.1 - 0.16 11.9 0.1 0.39 10.7 0.1 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE LRR_6 PF13516.6 EMC86583.1 - 0.3 11.2 40.2 4.4 7.6 0.1 10.2 11 0 0 11 11 9 0 Leucine Rich repeat AAA_23 PF13476.6 EMC86583.1 - 2.7 8.4 8.0 0.51 10.8 0.0 3.3 4 0 0 4 4 3 0 AAA domain Sugar_tr PF00083.24 EMC86584.1 - 1.1e-93 314.6 12.6 1.1e-68 232.2 1.8 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EMC86584.1 - 3.6e-15 55.7 23.9 9.1e-08 31.4 1.1 3.0 2 1 1 3 3 3 3 Major Facilitator Superfamily Ral PF11058.8 EMC86584.1 - 0.077 12.6 1.1 0.15 11.6 1.1 1.4 1 0 0 1 1 1 0 Antirestriction protein Ral PSI_integrin PF17205.3 EMC86584.1 - 1.7 8.5 5.9 3.3 7.5 5.9 1.5 1 0 0 1 1 1 0 Integrin plexin domain DUF4552 PF15089.6 EMC86585.1 - 2.6e-12 46.5 7.0 1.5e-05 24.3 0.1 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4552) Copine PF07002.16 EMC86586.1 - 3.6e-89 297.9 0.0 4.9e-89 297.5 0.0 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 EMC86586.1 - 1.3e-28 99.3 0.1 2.9e-14 53.2 0.1 2.3 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 EMC86586.1 - 4.2e-07 30.3 0.0 7.4e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus DIE2_ALG10 PF04922.12 EMC86587.1 - 2.3e-129 432.1 27.9 2.9e-129 431.8 27.9 1.1 1 0 0 1 1 1 1 DIE2/ALG10 family CGI-121 PF08617.10 EMC86588.1 - 9.1e-44 149.4 0.5 1e-43 149.3 0.5 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 TrmB PF01978.19 EMC86588.1 - 0.045 13.6 0.0 0.08 12.8 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB GTSE1_N PF15259.6 EMC86589.1 - 1.8e-54 183.9 1.4 3.6e-54 182.9 1.4 1.5 1 0 0 1 1 1 1 G-2 and S-phase expressed 1 KI67R PF08065.12 EMC86589.1 - 0.0023 18.4 0.6 0.0023 18.4 0.6 2.0 2 0 0 2 2 2 1 KI67R (NUC007) repeat tRNA_Me_trans PF03054.16 EMC86591.1 - 3.6e-126 420.7 0.0 4.3e-126 420.5 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase Histone PF00125.24 EMC86592.1 - 5.6e-26 91.4 0.4 7.2e-26 91.1 0.4 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC86592.1 - 9.1e-07 29.1 0.7 1.8e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EMC86592.1 - 0.0034 17.8 0.0 0.006 17.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 EMC86592.1 - 0.0047 17.0 0.3 0.0055 16.7 0.3 1.2 1 0 0 1 1 1 1 YscO-like protein GRAM PF02893.20 EMC86593.1 - 1.7e-22 79.4 0.0 3.6e-22 78.4 0.0 1.5 1 0 0 1 1 1 1 GRAM domain PRT_C PF08372.10 EMC86593.1 - 0.00057 19.7 0.1 0.0014 18.4 0.1 1.6 1 0 0 1 1 1 1 Plant phosphoribosyltransferase C-terminal DUF639 PF04842.12 EMC86593.1 - 0.041 13.3 0.6 0.071 12.5 0.6 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) betaPIX_CC PF16523.5 EMC86593.1 - 9.4 6.1 11.0 1.6 8.6 7.0 1.7 2 0 0 2 2 2 0 betaPIX coiled coil Ank_5 PF13857.6 EMC86594.1 - 1.4e-19 69.9 0.8 2.7e-11 43.5 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EMC86594.1 - 5.6e-18 65.2 0.0 7.4e-18 64.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_4 PF13637.6 EMC86594.1 - 3.4e-16 59.4 1.3 8.2e-12 45.4 0.3 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EMC86594.1 - 3e-14 52.7 0.7 7.3e-06 26.2 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 EMC86594.1 - 1.2e-12 48.2 0.0 2.1e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC86594.1 - 1.4e-12 46.6 0.1 4.4e-06 26.6 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Pkinase PF00069.25 EMC86594.1 - 5.1e-11 42.4 0.0 8.1e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Guanylate_cyc PF00211.20 EMC86598.1 - 4e-116 385.1 0.7 2.7e-62 209.7 0.2 2.2 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain DUF512 PF04459.12 EMC86598.1 - 0.043 13.1 0.0 0.083 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF512) DUF2207 PF09972.9 EMC86598.1 - 3.2 6.4 6.2 2.4 6.8 0.1 2.5 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) ArAE_2_N PF10337.9 EMC86599.1 - 0.2 10.7 0.1 0.26 10.3 0.1 1.1 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal Dynamin_N PF00350.23 EMC86600.1 - 1.7e-14 54.2 0.0 7.8e-13 48.8 0.0 2.6 2 1 0 2 2 2 1 Dynamin family EHD_N PF16880.5 EMC86600.1 - 8.3e-11 41.6 0.0 2.3e-10 40.2 0.0 1.8 1 0 0 1 1 1 1 N-terminal EH-domain containing protein MMR_HSR1 PF01926.23 EMC86600.1 - 1.7e-08 34.5 0.0 4.3e-08 33.2 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC86600.1 - 0.0012 18.8 0.0 0.22 11.4 0.0 3.4 4 0 0 4 4 4 1 RsgA GTPase Roc PF08477.13 EMC86600.1 - 0.095 12.9 0.0 9.9 6.4 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EMC86600.1 - 0.13 11.8 0.0 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain HLH PF00010.26 EMC86601.1 - 7.5e-12 45.0 0.1 6.9e-11 41.9 0.0 2.7 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain COE1_HLH PF16423.5 EMC86601.1 - 0.0016 18.1 0.0 0.0033 17.1 0.0 1.5 1 0 0 1 1 1 1 Transcription factor COE1 helix-loop-helix domain DUF4940 PF16298.5 EMC86601.1 - 0.4 10.3 4.6 0.43 10.2 2.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4940) Lzipper-MIP1 PF14389.6 EMC86601.1 - 2.2 8.6 23.7 5.8 7.3 16.6 3.8 3 1 1 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 zf-C2H2 PF00096.26 EMC86602.1 - 8.7e-12 44.8 30.2 7.8e-05 22.9 3.3 4.9 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC86602.1 - 2.8e-11 43.3 36.6 4.9e-07 29.9 3.3 4.7 4 1 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC86602.1 - 1.9e-05 25.1 22.3 0.017 15.9 0.8 4.5 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC86602.1 - 4e-05 23.5 1.0 4e-05 23.5 1.0 3.2 4 0 0 4 4 4 1 C2H2-type zinc finger zf-met PF12874.7 EMC86602.1 - 0.0089 16.4 12.7 0.042 14.3 1.1 3.5 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMC86602.1 - 0.067 13.5 0.8 0.067 13.5 0.8 3.8 3 1 1 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EMC86602.1 - 0.099 13.0 8.2 1.6 9.1 0.8 2.3 1 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) FOXP-CC PF16159.5 EMC86602.1 - 0.46 11.1 2.8 0.65 10.7 0.2 2.4 1 1 2 3 3 3 0 FOXP coiled-coil domain zf-C2H2_aberr PF17017.5 EMC86602.1 - 2 8.5 8.3 3.5 7.7 0.8 2.9 1 1 2 3 3 3 0 Aberrant zinc-finger zf_C2H2_ZHX PF18387.1 EMC86602.1 - 2.5 7.8 4.3 0.53 10.0 0.6 1.8 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain Pam16 PF03656.13 EMC86603.1 - 1.4e-41 141.5 1.5 1.5e-41 141.3 1.5 1.0 1 0 0 1 1 1 1 Pam16 WD40_4 PF16300.5 EMC86604.1 - 1.8e-34 117.4 0.5 3.5e-17 62.0 0.1 2.5 2 0 0 2 2 2 2 Type of WD40 repeat WD40 PF00400.32 EMC86604.1 - 5.1e-25 87.3 3.4 0.00014 22.5 0.1 7.9 7 0 0 7 7 7 5 WD domain, G-beta repeat DUF1899 PF08953.11 EMC86604.1 - 7.1e-17 61.0 0.0 6.6e-10 38.7 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF1899) ANAPC4_WD40 PF12894.7 EMC86604.1 - 2.4e-12 47.0 0.0 0.0027 18.0 0.0 4.3 2 2 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMC86604.1 - 0.23 10.4 0.0 3.7 6.4 0.0 2.8 4 0 0 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein LRR_6 PF13516.6 EMC86605.1 - 6.5e-57 184.8 36.1 2.2e-05 24.1 0.0 14.8 14 0 0 14 14 14 14 Leucine Rich repeat NACHT PF05729.12 EMC86605.1 - 1.1e-29 103.5 0.0 2.3e-29 102.4 0.0 1.6 1 0 0 1 1 1 1 NACHT domain NLRC4_HD2 PF17776.1 EMC86605.1 - 1.5e-23 83.7 0.6 1.5e-23 83.7 0.6 2.1 2 0 0 2 2 2 1 NLRC4 helical domain HD2 NOD2_WH PF17779.1 EMC86605.1 - 2.4e-15 56.6 0.4 2.4e-15 56.6 0.4 2.8 4 0 0 4 4 4 1 NOD2 winged helix domain LRR_8 PF13855.6 EMC86605.1 - 8.4e-06 25.5 42.2 0.014 15.2 0.8 9.4 3 3 4 7 7 7 4 Leucine rich repeat LRR_1 PF00560.33 EMC86605.1 - 8.9e-06 25.6 12.3 50 5.0 0.0 10.1 11 1 0 11 11 11 0 Leucine Rich Repeat LRR_4 PF12799.7 EMC86605.1 - 1e-05 25.7 42.3 0.061 13.8 1.8 9.4 3 2 9 12 12 12 7 Leucine Rich repeats (2 copies) FISNA PF14484.6 EMC86605.1 - 0.00076 19.7 0.0 0.0021 18.3 0.0 1.7 1 0 0 1 1 1 1 Fish-specific NACHT associated domain ABC_tran PF00005.27 EMC86605.1 - 0.062 13.8 6.8 1.9 9.0 0.0 4.4 4 0 0 4 4 4 0 ABC transporter FAM25 PF15825.5 EMC86605.1 - 2.9 8.3 4.0 24 5.4 0.0 4.1 5 0 0 5 5 5 0 FAM25 family Cluap1 PF10234.9 EMC86606.1 - 1.8e-114 381.7 12.3 2.5e-114 381.2 12.3 1.2 1 0 0 1 1 1 1 Clusterin-associated protein-1 SseC PF04888.12 EMC86606.1 - 0.0013 18.4 3.0 0.002 17.8 3.0 1.3 1 0 0 1 1 1 1 Secretion system effector C (SseC) like family BUD22 PF09073.10 EMC86606.1 - 4.1 6.7 23.4 6 6.1 23.4 1.4 1 1 0 1 1 1 0 BUD22 7tm_2 PF00002.24 EMC86607.1 - 8.1e-40 136.6 12.8 3.1e-39 134.7 12.8 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.11 EMC86607.1 - 0.13 11.4 6.3 0.18 10.9 6.3 1.5 1 1 0 1 1 1 0 Slime mold cyclic AMP receptor Ank_2 PF12796.7 EMC86608.1 - 8.9e-15 55.0 0.5 1.1e-13 51.5 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) SAM_1 PF00536.30 EMC86608.1 - 8e-13 48.6 0.0 1.6e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC86608.1 - 3.5e-12 46.3 0.0 7.1e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ank_3 PF13606.6 EMC86608.1 - 1.2e-11 43.8 0.2 2.7e-05 24.2 0.0 2.9 3 0 0 3 3 2 2 Ankyrin repeat Ank_4 PF13637.6 EMC86608.1 - 1.5e-11 44.6 0.1 1.4e-08 35.1 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EMC86608.1 - 9.5e-11 41.7 1.5 0.0001 22.5 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EMC86608.1 - 6.6e-09 35.9 0.3 8.7e-05 22.7 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) YlqD PF11068.8 EMC86608.1 - 0.024 15.0 5.2 0.024 15.0 5.2 1.6 2 0 0 2 2 2 0 YlqD protein IGR PF09597.10 EMC86608.1 - 0.099 12.8 0.0 0.38 10.9 0.0 2.0 2 0 0 2 2 2 0 IGR protein motif FH2 PF02181.23 EMC86608.1 - 0.17 11.0 2.2 0.32 10.1 2.2 1.4 1 0 0 1 1 1 0 Formin Homology 2 Domain HAUS6_N PF14661.6 EMC86608.1 - 0.26 10.9 2.1 0.47 10.0 2.1 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF4701 PF15773.5 EMC86609.1 - 1.9e-20 73.4 10.6 2.1e-20 73.2 10.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4701) RHH_5 PF07878.11 EMC86609.1 - 0.058 13.3 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 YscO PF07321.12 EMC86609.1 - 0.15 12.0 8.3 0.027 14.4 4.7 1.5 2 0 0 2 2 2 0 Type III secretion protein YscO SIT PF15330.6 EMC86609.1 - 0.22 12.0 7.5 0.038 14.4 3.2 1.9 2 1 1 3 3 3 0 SHP2-interacting transmembrane adaptor protein, SIT WDCP PF15390.6 EMC86609.1 - 2.2 6.6 8.2 2.4 6.4 8.2 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family MAT1 PF06391.13 EMC86609.1 - 2.3 8.0 12.2 1.1 9.1 9.7 1.6 1 1 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 NDK PF00334.19 EMC86612.1 - 6.6e-18 65.0 0.0 1.1e-17 64.3 0.0 1.2 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Pkinase PF00069.25 EMC86613.1 - 3.1e-35 121.8 0.0 3.5e-35 121.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC86613.1 - 2.5e-20 72.8 0.0 2.7e-20 72.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC86613.1 - 4.2e-07 29.6 0.0 4.6e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC86613.1 - 0.00035 20.0 0.0 0.00043 19.7 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 EMC86613.1 - 0.0079 15.2 0.0 0.0092 15.0 0.0 1.2 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase APH PF01636.23 EMC86613.1 - 0.043 13.7 0.0 0.056 13.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EMC86613.1 - 0.11 11.2 0.0 0.13 11.0 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Xpo1 PF08389.12 EMC86614.1 - 1.3e-22 80.5 0.1 1.3e-22 80.5 0.1 6.1 6 2 0 6 6 6 2 Exportin 1-like protein IBN_N PF03810.19 EMC86614.1 - 4.5e-09 36.1 0.4 1.8e-08 34.2 0.0 2.4 2 0 0 2 2 2 1 Importin-beta N-terminal domain NDK PF00334.19 EMC86615.1 - 1.3e-54 183.9 0.0 1.5e-54 183.7 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase adh_short_C2 PF13561.6 EMC86616.1 - 6.2e-46 156.8 0.0 7.7e-46 156.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMC86616.1 - 4.9e-33 114.2 0.0 6.4e-33 113.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMC86616.1 - 0.00045 20.2 0.0 0.0006 19.8 0.0 1.2 1 0 0 1 1 1 1 KR domain PsiA PF06952.11 EMC86616.1 - 0.085 12.1 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 PsiA protein RBD-FIP PF09457.10 EMC86617.1 - 4.5e-21 74.5 1.3 4.5e-21 74.5 1.3 4.7 5 0 0 5 5 5 1 FIP domain EF-hand_8 PF13833.6 EMC86617.1 - 0.002 17.9 0.2 0.022 14.6 0.1 2.8 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EMC86617.1 - 0.0027 17.1 0.1 5.7 6.7 0.0 3.4 3 0 0 3 3 3 2 EF hand DivIC PF04977.15 EMC86617.1 - 0.0038 17.0 3.6 0.0038 17.0 3.6 6.1 2 1 3 5 5 5 1 Septum formation initiator ZapB PF06005.12 EMC86617.1 - 0.0084 16.5 3.7 0.0084 16.5 3.7 4.8 2 1 1 3 3 2 1 Cell division protein ZapB HALZ PF02183.18 EMC86617.1 - 0.011 16.0 4.5 0.011 16.0 4.5 5.4 4 1 1 5 5 5 0 Homeobox associated leucine zipper EF-hand_6 PF13405.6 EMC86617.1 - 0.028 14.4 0.3 19 5.5 0.0 3.3 3 0 0 3 3 3 0 EF-hand domain EF-hand_7 PF13499.6 EMC86617.1 - 0.044 14.2 0.0 0.044 14.2 0.0 4.1 3 2 0 3 3 3 0 EF-hand domain pair HOOK PF05622.12 EMC86617.1 - 0.16 10.1 50.1 6.9 4.7 50.1 2.0 1 1 0 1 1 1 0 HOOK protein Tubulin_3 PF14881.6 EMC86617.1 - 0.25 11.0 0.1 0.25 11.0 0.1 3.1 2 1 0 3 3 3 0 Tubulin domain HAP1_N PF04849.13 EMC86617.1 - 1 8.5 56.0 3.7 6.7 52.1 2.5 1 1 1 2 2 2 0 HAP1 N-terminal conserved region bZIP_1 PF00170.21 EMC86617.1 - 2.3 8.4 45.1 0.1 12.7 2.7 5.7 2 1 4 6 6 6 0 bZIP transcription factor Leu_zip PF15294.6 EMC86617.1 - 3 7.3 49.2 0.27 10.7 23.5 4.3 1 1 3 4 4 4 0 Leucine zipper Jnk-SapK_ap_N PF09744.9 EMC86617.1 - 3.4 7.9 61.2 0.15 12.3 18.2 4.5 1 1 3 4 4 4 0 JNK_SAPK-associated protein-1 Septin PF00735.18 EMC86618.1 - 9.4e-112 372.9 0.2 1.1e-111 372.7 0.2 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EMC86618.1 - 7.8e-08 32.4 0.2 1.8e-07 31.3 0.2 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC86618.1 - 4.1e-06 26.8 1.5 2.7e-05 24.1 0.5 2.2 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 EMC86618.1 - 1.8e-05 24.2 0.1 3e-05 23.4 0.1 1.4 1 0 0 1 1 1 1 AIG1 family Roc PF08477.13 EMC86618.1 - 0.0002 21.6 0.2 0.00041 20.5 0.2 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EMC86618.1 - 0.0007 19.2 0.4 0.33 10.5 0.1 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EMC86618.1 - 0.0011 19.4 0.1 0.0032 17.9 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain FtsK_SpoIIIE PF01580.18 EMC86618.1 - 0.0012 18.3 0.1 0.002 17.5 0.1 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family Dynamin_N PF00350.23 EMC86618.1 - 0.0026 17.8 1.9 0.15 12.1 0.7 2.4 1 1 1 2 2 2 1 Dynamin family AAA_22 PF13401.6 EMC86618.1 - 0.0032 17.8 0.0 0.0096 16.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain Ras PF00071.22 EMC86618.1 - 0.0037 16.9 0.1 0.008 15.8 0.1 1.6 1 0 0 1 1 1 1 Ras family IIGP PF05049.13 EMC86618.1 - 0.0047 16.0 0.7 0.068 12.2 0.0 2.5 3 0 0 3 3 3 1 Interferon-inducible GTPase (IIGP) Gtr1_RagA PF04670.12 EMC86618.1 - 0.0051 16.2 0.7 0.52 9.6 0.0 2.2 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region ABC_tran PF00005.27 EMC86618.1 - 0.0064 17.0 0.7 0.02 15.4 0.7 1.9 1 1 0 1 1 1 1 ABC transporter AAA_32 PF13654.6 EMC86618.1 - 0.022 13.6 0.0 0.032 13.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EMC86618.1 - 0.026 14.3 0.2 0.14 11.9 0.1 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_7 PF12775.7 EMC86618.1 - 0.027 14.0 0.2 0.052 13.1 0.2 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region G-alpha PF00503.20 EMC86618.1 - 0.035 13.3 1.0 0.49 9.5 0.3 2.1 1 1 1 2 2 2 0 G-protein alpha subunit AAA_24 PF13479.6 EMC86618.1 - 0.039 13.7 0.2 0.27 10.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EMC86618.1 - 0.04 13.6 0.1 0.072 12.8 0.1 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain NB-ARC PF00931.22 EMC86618.1 - 0.062 12.5 0.3 0.11 11.7 0.3 1.4 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.22 EMC86618.1 - 0.095 13.1 0.2 0.26 11.7 0.0 1.9 2 0 0 2 2 2 0 RNA helicase Ploopntkinase3 PF18751.1 EMC86618.1 - 0.097 12.6 0.1 0.2 11.5 0.1 1.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 Mg_chelatase PF01078.21 EMC86618.1 - 0.13 11.6 0.1 11 5.3 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI MARVEL PF01284.23 EMC86619.1 - 4.4e-18 65.7 39.5 3e-10 40.3 11.5 2.0 2 0 0 2 2 2 2 Membrane-associating domain IP_trans PF02121.18 EMC86620.1 - 1.7e-87 293.1 0.1 2e-87 292.9 0.1 1.1 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein zf-MYND PF01753.18 EMC86621.1 - 2.5e-11 43.5 9.2 2.5e-11 43.5 9.2 1.8 2 0 0 2 2 2 1 MYND finger Tnp_zf-ribbon_2 PF13842.6 EMC86621.1 - 1.2 10.0 6.7 16 6.4 0.1 2.4 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon zf-C6H2 PF15801.5 EMC86621.1 - 1.3 9.4 7.9 2.8 8.3 7.9 1.6 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding DZR PF12773.7 EMC86621.1 - 2.6 8.2 7.8 16 5.6 7.8 2.1 1 1 0 1 1 1 0 Double zinc ribbon TPR_8 PF13181.6 EMC86622.1 - 3e-15 55.1 15.5 1.4e-05 24.9 0.0 6.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 EMC86622.1 - 5.2e-15 54.3 18.9 8.8e-05 22.3 0.1 6.8 7 0 0 7 7 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 EMC86622.1 - 1.4e-13 50.0 28.0 5.6e-06 25.9 0.1 7.2 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 EMC86622.1 - 1.4e-09 38.0 5.5 0.093 13.6 0.0 5.8 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 EMC86622.1 - 5.7e-05 22.7 9.5 0.0015 18.2 0.0 5.1 4 1 1 5 5 5 1 TPR repeat TPR_12 PF13424.6 EMC86622.1 - 0.00011 22.4 18.6 0.0076 16.5 0.9 5.0 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMC86622.1 - 0.00025 21.5 9.1 0.022 15.3 0.2 4.6 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 EMC86622.1 - 0.0014 18.8 5.6 1.3 9.6 0.1 4.6 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EMC86622.1 - 0.0075 16.2 16.4 0.096 12.8 0.0 6.5 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_21 PF09976.9 EMC86622.1 - 0.015 15.0 0.0 0.05 13.3 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain TPR_16 PF13432.6 EMC86622.1 - 0.016 15.8 11.2 0.31 11.7 0.0 5.0 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_9 PF13371.6 EMC86622.1 - 0.022 14.9 0.6 0.41 10.8 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4085 PF13315.6 EMC86622.1 - 0.06 13.0 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) Tir_receptor_N PF07490.11 EMC86622.1 - 0.087 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) N-terminus TPR_6 PF13174.6 EMC86622.1 - 6.6 7.6 11.9 13 6.7 0.0 5.0 5 1 0 5 5 5 0 Tetratricopeptide repeat WD40 PF00400.32 EMC86623.1 - 2.8e-50 167.2 41.8 3.6e-07 30.8 0.2 20.4 20 0 0 20 20 20 12 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC86623.1 - 8.6e-23 80.5 2.0 0.0011 19.3 0.2 11.8 9 4 5 14 14 14 4 Anaphase-promoting complex subunit 4 WD40 domain DUF667 PF05018.13 EMC86623.1 - 2.4e-13 50.2 0.0 9.6e-13 48.3 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF667) Ge1_WD40 PF16529.5 EMC86623.1 - 4.3e-06 25.9 5.7 0.1 11.6 0.0 5.1 6 0 0 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein HELP PF03451.14 EMC86623.1 - 0.00056 19.7 0.0 1.3 8.9 0.0 2.6 2 0 0 2 2 2 2 HELP motif RAB3GAP2_N PF14655.6 EMC86623.1 - 0.012 14.9 0.4 4.5 6.4 0.0 3.5 3 1 1 4 4 4 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Coatomer_WDAD PF04053.14 EMC86623.1 - 0.013 14.6 0.0 0.043 12.9 0.0 1.8 2 0 0 2 2 2 0 Coatomer WD associated region PQQ_2 PF13360.6 EMC86623.1 - 0.026 14.1 0.3 9.4 5.7 0.0 4.1 4 0 0 4 4 4 0 PQQ-like domain BBS2_Mid PF14783.6 EMC86623.1 - 0.032 14.3 0.0 9.9 6.3 0.0 4.0 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region Nucleoporin_N PF08801.11 EMC86623.1 - 0.035 12.9 0.7 1.8 7.3 0.0 4.0 3 1 0 4 4 4 0 Nup133 N terminal like Nup160 PF11715.8 EMC86623.1 - 0.29 9.7 8.0 0.55 8.8 0.0 4.7 5 1 0 5 5 5 0 Nucleoporin Nup120/160 PQQ_3 PF13570.6 EMC86623.1 - 0.99 10.0 4.1 38 5.0 0.0 5.5 7 0 0 7 7 6 0 PQQ-like domain EF_assoc_2 PF08356.12 EMC86624.1 - 1.4e-36 124.4 0.0 3.5e-36 123.1 0.0 1.7 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.12 EMC86624.1 - 2.9e-24 84.4 0.6 2.2e-23 81.6 0.0 2.4 2 1 0 2 2 2 1 EF hand associated Ras PF00071.22 EMC86624.1 - 1.2e-21 76.9 0.0 9.3e-16 57.8 0.0 2.3 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EMC86624.1 - 1.1e-08 35.3 0.0 2.2e-05 24.7 0.0 2.9 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase EF-hand_7 PF13499.6 EMC86624.1 - 7.3e-07 29.5 0.0 0.0037 17.7 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EMC86624.1 - 1.1e-06 28.1 0.7 0.00016 21.3 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 EMC86624.1 - 1.5e-06 27.3 0.5 0.0012 18.3 0.0 2.5 2 0 0 2 2 2 2 EF hand MMR_HSR1 PF01926.23 EMC86624.1 - 0.00048 20.2 0.0 0.38 10.9 0.0 2.6 2 1 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_5 PF13202.6 EMC86624.1 - 0.00086 18.7 0.1 0.002 17.5 0.1 1.6 1 0 0 1 1 1 1 EF hand Dynamin_N PF00350.23 EMC86624.1 - 0.00093 19.3 0.0 0.48 10.5 0.0 2.3 2 0 0 2 2 2 2 Dynamin family RsgA_GTPase PF03193.16 EMC86624.1 - 0.021 14.7 0.0 45 3.9 0.0 4.5 4 1 1 5 5 5 0 RsgA GTPase SPARC_Ca_bdg PF10591.9 EMC86624.1 - 0.026 14.8 0.1 2.7 8.4 0.0 2.5 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region ABC_tran PF00005.27 EMC86624.1 - 0.062 13.8 0.0 6.5 7.3 0.0 2.4 2 0 0 2 2 2 0 ABC transporter EF-hand_10 PF14788.6 EMC86624.1 - 0.068 13.0 1.3 2.3 8.1 0.1 2.5 2 0 0 2 2 2 0 EF hand EF-hand_8 PF13833.6 EMC86624.1 - 0.098 12.5 0.1 24 4.9 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain pair AAA_14 PF13173.6 EMC86624.1 - 0.11 12.5 0.0 10 6.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain Rhomboid PF01694.22 EMC86625.1 - 5.4e-36 123.8 8.8 9.6e-36 123.0 8.8 1.4 1 0 0 1 1 1 1 Rhomboid family U-box PF04564.15 EMC86626.1 - 3.5e-31 107.2 0.0 5.7e-31 106.5 0.0 1.3 1 0 0 1 1 1 1 U-box domain CHIP_TPR_N PF18391.1 EMC86626.1 - 1.3e-25 90.0 13.9 1.3e-25 90.0 13.9 1.7 2 0 0 2 2 2 1 CHIP N-terminal tetratricopeptide repeat domain TPR_1 PF00515.28 EMC86626.1 - 8.8e-16 57.0 6.9 8.5e-10 38.0 0.8 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMC86626.1 - 1.8e-12 46.3 5.9 1e-05 25.2 0.6 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC86626.1 - 3.8e-11 43.1 1.6 8.8e-11 41.9 1.6 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EMC86626.1 - 7.6e-11 42.2 10.9 1.5e-08 34.8 4.6 2.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMC86626.1 - 4.6e-10 38.9 4.1 0.00024 21.1 0.4 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMC86626.1 - 3.7e-07 30.6 4.1 4.4e-07 30.3 2.9 1.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMC86626.1 - 1.9e-06 27.4 0.6 0.0067 16.1 0.0 2.4 1 1 1 2 2 2 2 TPR repeat TPR_9 PF13371.6 EMC86626.1 - 1.8e-05 24.8 0.5 4e-05 23.7 0.5 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 EMC86626.1 - 2.3e-05 25.0 0.2 3.9e-05 24.2 0.2 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 EMC86626.1 - 2.3e-05 24.4 0.7 0.37 11.3 0.3 2.9 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMC86626.1 - 6e-05 22.8 3.4 0.14 12.3 0.3 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMC86626.1 - 0.00025 21.6 0.3 0.016 16.0 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMC86626.1 - 0.00029 21.3 3.4 0.62 10.8 0.3 2.9 3 0 0 3 3 2 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 EMC86626.1 - 0.0056 16.1 1.2 0.044 13.3 0.1 2.3 2 0 0 2 2 2 1 SHNi-TPR TPR_10 PF13374.6 EMC86626.1 - 0.011 15.6 3.2 0.45 10.5 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-NOSIP PF15906.5 EMC86626.1 - 0.058 13.5 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein TPR_20 PF14561.6 EMC86626.1 - 2.5 8.5 8.2 14 6.1 1.4 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Cupin_8 PF13621.6 EMC86627.1 - 0.00045 20.0 0.0 0.0026 17.5 0.0 1.9 1 1 0 1 1 1 1 Cupin-like domain HTH_28 PF13518.6 EMC86627.1 - 0.062 13.4 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain WD40 PF00400.32 EMC86628.1 - 8.3e-18 64.4 3.1 1.5e-05 25.7 0.1 6.2 5 0 0 5 5 5 5 WD domain, G-beta repeat Zn_ribbon_17 PF17120.5 EMC86628.1 - 7e-05 22.4 18.4 7e-05 22.4 18.4 2.6 1 1 1 2 2 2 1 Zinc-ribbon, C4HC2 type ANAPC4_WD40 PF12894.7 EMC86628.1 - 0.0033 17.7 0.1 0.87 9.9 0.0 2.9 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain DZR PF12773.7 EMC86628.1 - 5.2 7.2 14.0 4.1 7.5 11.9 2.0 1 1 0 1 1 1 0 Double zinc ribbon LRR_1 PF00560.33 EMC86629.1 - 4.6e-06 26.5 4.1 0.6 10.9 0.2 3.4 3 0 0 3 3 3 3 Leucine Rich Repeat LRR_6 PF13516.6 EMC86629.1 - 4.7e-05 23.1 0.7 0.2 11.8 0.0 3.1 3 0 0 3 3 3 2 Leucine Rich repeat LRR_4 PF12799.7 EMC86629.1 - 0.00011 22.5 0.7 0.017 15.5 0.1 2.1 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMC86629.1 - 0.044 13.6 1.9 0.16 11.8 1.9 2.1 1 1 0 1 1 1 0 Leucine rich repeat F-box-like PF12937.7 EMC86630.1 - 0.0062 16.4 1.0 0.0062 16.4 1.0 1.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EMC86630.1 - 0.0092 15.8 1.9 0.014 15.3 0.1 2.1 2 0 0 2 2 2 1 F-box domain UPF0149 PF03695.13 EMC86633.1 - 0.0012 19.2 2.4 0.0012 19.2 2.4 2.0 2 1 0 2 2 2 1 Uncharacterised protein family (UPF0149) DUF1664 PF07889.12 EMC86633.1 - 0.0058 16.7 16.1 0.02 14.9 5.3 3.7 4 0 0 4 4 4 1 Protein of unknown function (DUF1664) IL22 PF14565.6 EMC86633.1 - 0.025 14.8 1.6 0.25 11.6 0.2 2.5 1 1 1 2 2 2 0 Interleukin 22 IL-10-related T-cell-derived-inducible factor DUF2271 PF10029.9 EMC86633.1 - 0.035 13.7 0.0 0.079 12.6 0.0 1.6 1 0 0 1 1 1 0 Predicted periplasmic protein (DUF2271) BLOC1S3 PF15753.5 EMC86633.1 - 0.088 12.9 9.1 0.056 13.6 6.0 2.3 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 OmpH PF03938.14 EMC86633.1 - 0.15 12.4 29.4 0.031 14.6 11.7 3.2 2 1 1 3 3 3 0 Outer membrane protein (OmpH-like) DUF4844 PF16133.5 EMC86633.1 - 0.19 12.3 3.4 0.5 10.9 3.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4844) RBD-FIP PF09457.10 EMC86633.1 - 0.21 11.5 0.3 0.21 11.5 0.3 3.4 2 1 0 2 2 2 0 FIP domain PhoU PF01895.19 EMC86633.1 - 0.28 11.7 0.2 0.28 11.7 0.2 2.9 3 1 0 3 3 3 0 PhoU domain TMPIT PF07851.13 EMC86633.1 - 0.41 9.8 12.6 0.15 11.3 3.5 2.5 2 1 0 2 2 2 0 TMPIT-like protein DUF4763 PF15960.5 EMC86633.1 - 0.59 9.4 21.4 0.16 11.2 1.5 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF4763) DUF4407 PF14362.6 EMC86633.1 - 0.72 9.1 15.0 2.4 7.4 9.4 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Filament PF00038.21 EMC86633.1 - 0.91 9.0 27.4 3.6 7.1 3.7 3.0 2 1 0 2 2 2 0 Intermediate filament protein PEPcase_2 PF14010.6 EMC86633.1 - 0.98 7.8 6.3 0.22 10.0 0.2 2.1 2 0 0 2 2 2 0 Phosphoenolpyruvate carboxylase Hemerythrin PF01814.23 EMC86633.1 - 1.2 9.8 9.8 0.79 10.3 1.8 3.4 2 2 1 3 3 3 0 Hemerythrin HHE cation binding domain Spc7 PF08317.11 EMC86633.1 - 1.3 7.8 28.8 0.11 11.3 11.1 2.8 2 1 0 2 2 2 0 Spc7 kinetochore protein T3SSipB PF16535.5 EMC86633.1 - 4.2 7.8 11.5 0.23 11.9 4.3 2.3 3 0 0 3 3 3 0 Type III cell invasion protein SipB EzrA PF06160.12 EMC86633.1 - 4.3 5.4 21.9 0.017 13.3 8.7 2.9 2 1 0 2 2 2 0 Septation ring formation regulator, EzrA Ribosomal_S20p PF01649.18 EMC86633.1 - 4.8 7.9 13.3 3.7 8.2 0.7 4.3 4 1 1 5 5 5 0 Ribosomal protein S20 DLP_helical PF18709.1 EMC86633.1 - 7 5.8 14.5 0.12 11.6 4.5 2.8 3 1 0 3 3 3 0 Dynamin-like helical domain LRR_8 PF13855.6 EMC86634.1 - 6.8e-97 317.2 97.4 2.2e-18 65.7 1.6 9.6 4 2 6 10 10 10 9 Leucine rich repeat LRR_4 PF12799.7 EMC86634.1 - 1.9e-39 133.0 61.5 1.1e-06 28.8 0.3 11.2 5 2 8 14 14 14 13 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC86634.1 - 8.5e-36 122.7 0.0 1.4e-09 38.0 0.0 4.7 1 1 3 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EMC86634.1 - 6.6e-15 53.4 72.1 1.1 10.1 0.5 19.1 19 1 1 20 20 20 5 Leucine Rich Repeat LRR_9 PF14580.6 EMC86634.1 - 2.1e-13 50.2 19.5 2.8e-05 23.7 1.7 5.7 1 1 5 6 6 6 6 Leucine-rich repeat LRRNT PF01462.18 EMC86634.1 - 5.4e-07 29.1 2.5 5.4e-07 29.1 2.5 2.2 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain Herpes_BTRF1 PF04682.12 EMC86634.1 - 0.011 15.0 0.8 0.011 15.0 0.8 2.5 2 1 1 3 3 3 0 Herpesvirus BTRF1 protein conserved region LRRCT PF01463.24 EMC86634.1 - 0.033 14.7 0.1 0.17 12.5 0.1 2.4 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain ParA PF10609.9 EMC86635.1 - 1.4e-99 332.5 0.0 1.6e-99 332.3 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EMC86635.1 - 3.3e-12 46.6 0.0 1.9e-11 44.1 0.0 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EMC86635.1 - 4.8e-08 33.1 0.2 4.3e-07 30.0 0.2 2.1 1 1 0 1 1 1 1 AAA domain MipZ PF09140.11 EMC86635.1 - 6.5e-08 32.2 0.0 2.4e-07 30.3 0.0 1.7 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 EMC86635.1 - 1.5e-06 27.7 0.2 6.9e-06 25.5 0.1 2.0 3 0 0 3 3 3 1 Anion-transporting ATPase AAA_26 PF13500.6 EMC86635.1 - 1.9e-06 27.8 0.0 1.8e-05 24.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain MeaB PF03308.16 EMC86635.1 - 5.7e-05 22.2 0.1 8.2e-05 21.7 0.1 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Fer4_NifH PF00142.18 EMC86635.1 - 0.00011 21.8 0.0 0.0042 16.6 0.0 2.2 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CBP_BcsQ PF06564.12 EMC86635.1 - 0.0012 18.3 0.0 0.0029 17.1 0.0 1.6 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ AAA_25 PF13481.6 EMC86635.1 - 0.0045 16.6 0.0 0.0088 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 EMC86635.1 - 0.0093 15.9 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase Zeta_toxin PF06414.12 EMC86635.1 - 0.025 13.9 0.0 0.039 13.2 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin SRP54 PF00448.22 EMC86635.1 - 0.03 13.9 0.0 0.11 12.1 0.0 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain KTI12 PF08433.10 EMC86635.1 - 0.031 13.7 0.0 0.044 13.2 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 CLP1_P PF16575.5 EMC86635.1 - 0.062 13.1 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop NB-ARC PF00931.22 EMC86635.1 - 0.081 12.1 0.2 0.12 11.5 0.2 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.6 EMC86635.1 - 0.11 13.0 0.0 0.17 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EMC86635.1 - 0.12 12.7 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain NTPase_1 PF03266.15 EMC86635.1 - 0.23 11.4 0.2 0.45 10.4 0.2 1.4 1 0 0 1 1 1 0 NTPase RsgA_GTPase PF03193.16 EMC86635.1 - 0.33 10.9 0.8 0.74 9.7 0.8 1.5 1 0 0 1 1 1 0 RsgA GTPase SPRY PF00622.28 EMC86636.1 - 1.1e-18 67.5 0.2 2.5e-18 66.3 0.1 1.6 2 0 0 2 2 2 1 SPRY domain SOCS_box PF07525.16 EMC86636.1 - 0.00034 20.9 2.1 0.00068 20.0 2.1 1.5 1 0 0 1 1 1 1 SOCS box NDK PF00334.19 EMC86637.1 - 9.7e-55 184.3 0.0 1.1e-54 184.1 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase PSI_PsaJ PF01701.18 EMC86637.1 - 0.025 15.1 0.0 0.042 14.4 0.0 1.3 1 0 0 1 1 1 0 Photosystem I reaction centre subunit IX / PsaJ UBN_AB PF14075.6 EMC86638.1 - 1.3e-62 211.3 1.4 8e-46 156.4 0.2 4.4 3 2 2 5 5 5 2 Ubinuclein conserved middle domain HUN PF08729.10 EMC86638.1 - 2e-19 69.3 0.6 2e-19 69.3 0.6 2.4 2 0 0 2 2 2 1 HPC2 and ubinuclein domain MukF_M PF17192.4 EMC86638.1 - 0.019 14.7 0.0 0.043 13.6 0.0 1.5 1 0 0 1 1 1 0 MukF middle domain CpxA_peri PF16527.5 EMC86638.1 - 0.059 13.7 2.5 2 8.8 1.1 2.9 2 0 0 2 2 2 0 Two-component sensor protein CpxA, periplasmic domain Cellulose_synt PF03552.14 EMC86638.1 - 1.3 7.5 3.1 1.9 6.9 3.1 1.2 1 0 0 1 1 1 0 Cellulose synthase SH3_10 PF17902.1 EMC86639.1 - 1.6e-18 66.5 0.0 7.5e-18 64.4 0.0 2.3 2 0 0 2 2 2 1 SH3 domain Plectin PF00681.20 EMC86639.1 - 0.0035 17.2 0.0 0.64 9.9 0.0 2.7 2 0 0 2 2 2 2 Plectin repeat ATG16 PF08614.11 EMC86639.1 - 0.004 17.4 21.3 0.004 17.4 21.3 13.2 7 4 3 13 13 13 3 Autophagy protein 16 (ATG16) PDZ PF00595.24 EMC86640.1 - 1.8e-11 44.2 0.0 4.3e-11 43.0 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC86640.1 - 0.0066 16.3 0.0 0.027 14.3 0.0 2.1 2 0 0 2 2 2 1 PDZ domain DUF1192 PF06698.11 EMC86640.1 - 0.0077 16.3 5.8 0.12 12.4 1.1 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1192) Laminin_II PF06009.12 EMC86640.1 - 0.073 13.1 8.9 0.14 12.1 8.9 1.5 1 0 0 1 1 1 0 Laminin Domain II PKcGMP_CC PF16808.5 EMC86640.1 - 0.082 12.8 5.9 3.5 7.6 0.4 3.3 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase TPR_MLP1_2 PF07926.12 EMC86640.1 - 0.32 11.1 23.2 0.053 13.6 10.3 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF2730 PF10805.8 EMC86640.1 - 0.32 11.1 5.9 0.6 10.2 1.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) CCDC74_C PF14917.6 EMC86640.1 - 0.39 11.2 5.6 0.73 10.4 5.0 1.8 1 1 0 1 1 1 0 Coiled coil protein 74, C terminal Med9 PF07544.13 EMC86640.1 - 0.44 10.7 8.8 0.29 11.2 3.1 2.6 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF5082 PF16888.5 EMC86640.1 - 1.5 9.1 9.9 3.2 8.1 9.9 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) FUSC PF04632.12 EMC86640.1 - 3.3 6.1 10.6 4.4 5.7 10.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family GIT_CC PF16559.5 EMC86640.1 - 4.6 7.2 12.5 9.8 6.1 4.6 3.4 2 2 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor RRP36 PF06102.12 EMC86640.1 - 8.7 6.3 15.4 1.8 8.5 4.2 2.6 1 1 1 2 2 2 0 rRNA biogenesis protein RRP36 PRELI PF04707.14 EMC86641.1 - 4.2e-47 159.9 0.5 6.6e-47 159.2 0.5 1.3 1 0 0 1 1 1 1 PRELI-like family CRAL_TRIO PF00650.20 EMC86641.1 - 1.1e-42 145.4 0.0 3.2e-42 144.0 0.0 1.7 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EMC86641.1 - 2.1e-07 31.0 0.1 5.3e-07 29.7 0.1 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain NAGPA PF09992.9 EMC86642.1 - 9.8e-40 136.5 0.1 1.3e-39 136.2 0.1 1.1 1 0 0 1 1 1 1 Phosphodiester glycosidase EGF_2 PF07974.13 EMC86642.1 - 0.0034 17.7 32.1 0.0097 16.3 12.2 4.9 3 1 0 3 3 3 3 EGF-like domain EGF_Tenascin PF18720.1 EMC86642.1 - 0.03 14.4 8.6 0.03 14.4 8.6 4.1 4 1 0 4 4 4 0 Tenascin EGF domain Glycos_transf_1 PF00534.20 EMC86643.1 - 7.8e-10 38.6 0.0 1.1e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EMC86643.1 - 1.7e-06 28.5 0.0 2.3e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EMC86643.1 - 0.00053 20.0 0.1 0.00084 19.4 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 EMC86643.1 - 0.013 15.9 0.0 0.021 15.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 EMC86643.1 - 0.029 14.8 0.0 0.052 13.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 Methyltransf_16 PF10294.9 EMC86644.1 - 6.6e-18 65.1 0.1 1.4e-08 34.6 0.1 2.1 1 1 0 2 2 2 2 Lysine methyltransferase MTS PF05175.14 EMC86644.1 - 0.16 11.5 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_25 PF13649.6 EMC86644.1 - 0.17 12.6 0.0 0.43 11.3 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Peptidase_C2 PF00648.21 EMC86646.1 - 1.3e-80 270.6 0.0 1.8e-80 270.1 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease zf-RanBP PF00641.18 EMC86646.1 - 2.1e-26 90.9 69.7 6.7e-08 31.7 1.9 7.6 8 0 0 8 8 8 6 Zn-finger in Ran binding protein and others DZR PF12773.7 EMC86646.1 - 4.6e-05 23.4 57.6 0.083 12.9 8.4 6.3 6 0 0 6 6 6 5 Double zinc ribbon DUF3615 PF12274.8 EMC86646.1 - 1.2 9.7 19.0 1.8 9.1 0.3 4.9 5 1 0 5 5 5 0 Protein of unknown function (DUF3615) zf-C2H2_7 PF15269.6 EMC86647.1 - 5.8e-39 132.0 11.7 1.3e-38 130.9 11.7 1.6 1 0 0 1 1 1 1 Zinc-finger zf-H2C2_5 PF13909.6 EMC86647.1 - 0.0082 15.9 6.7 0.02 14.6 6.7 1.7 1 0 0 1 1 1 1 C2H2-type zinc-finger domain NHL PF01436.21 EMC86648.1 - 7.6e-12 44.6 1.9 0.00012 21.9 0.1 3.3 3 0 0 3 3 3 2 NHL repeat SGL PF08450.12 EMC86648.1 - 0.017 14.7 0.0 0.73 9.4 0.0 2.0 1 1 1 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Gpi1 PF05024.15 EMC86649.1 - 4e-65 219.4 9.8 9.1e-65 218.2 9.8 1.6 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) MDM10 PF12519.8 EMC86649.1 - 0.15 10.9 0.0 0.24 10.2 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Ras PF00071.22 EMC86650.1 - 2.5e-34 118.2 0.0 2.9e-34 118.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC86650.1 - 2e-14 53.8 0.0 2.8e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC86650.1 - 0.0035 16.8 0.0 0.0037 16.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF938 PF06080.12 EMC86651.1 - 1.3e-42 145.9 0.0 1.5e-42 145.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_25 PF13649.6 EMC86651.1 - 2.9e-07 31.1 0.0 4.3e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC86651.1 - 6.6e-06 26.8 0.0 1e-05 26.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EMC86651.1 - 3.4e-05 23.5 0.0 6.6e-05 22.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 EMC86651.1 - 0.028 15.1 0.0 0.054 14.1 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 EMC86651.1 - 0.088 12.5 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 EMC86651.1 - 0.11 12.3 0.0 0.23 11.3 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain FAM195 PF14799.6 EMC86652.1 - 3.4e-31 107.6 0.1 3.8e-31 107.5 0.1 1.0 1 0 0 1 1 1 1 FAM195 family LAP2alpha PF11560.8 EMC86652.1 - 0.064 12.7 0.0 0.07 12.6 0.0 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 2 alpha PPDFL PF15060.6 EMC86652.1 - 0.17 12.4 0.0 0.24 12.0 0.0 1.2 1 0 0 1 1 1 0 Differentiation and proliferation regulator ABC2_membrane_3 PF12698.7 EMC86653.1 - 3.8e-63 213.7 37.2 4.6e-35 121.4 22.6 2.3 2 0 0 2 2 2 2 ABC-2 family transporter protein ABC_tran PF00005.27 EMC86653.1 - 6.1e-49 166.1 0.0 6.8e-24 84.9 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EMC86653.1 - 5e-19 69.2 0.1 9.3e-06 25.7 0.0 4.3 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EMC86653.1 - 0.00026 20.9 0.9 0.0057 16.6 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase SbcCD_C PF13558.6 EMC86653.1 - 0.00078 19.6 0.0 0.024 14.9 0.0 3.0 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 EMC86653.1 - 0.00098 19.7 4.7 0.039 14.5 0.1 3.1 3 0 0 3 3 3 1 AAA domain DUF4162 PF13732.6 EMC86653.1 - 0.0013 19.4 0.0 0.25 12.1 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4162) AAA_30 PF13604.6 EMC86653.1 - 0.0059 16.3 0.2 0.34 10.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 EMC86653.1 - 0.021 14.3 0.1 13 5.2 0.0 3.2 3 1 0 4 4 4 0 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EMC86653.1 - 0.028 14.5 0.4 1.2 9.2 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_15 PF13175.6 EMC86653.1 - 0.031 14.0 0.0 0.34 10.6 0.0 2.4 3 0 0 3 3 3 0 AAA ATPase domain AAA_22 PF13401.6 EMC86653.1 - 0.033 14.4 2.3 1.7 8.9 0.1 3.3 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 EMC86653.1 - 0.036 13.8 2.0 0.41 10.4 0.1 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain Arf PF00025.21 EMC86653.1 - 0.081 12.4 0.7 13 5.2 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_16 PF13191.6 EMC86653.1 - 0.09 13.2 0.1 1.4 9.3 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 EMC86653.1 - 0.12 12.1 1.6 26 4.4 0.2 3.1 3 0 0 3 3 3 0 AAA domain SRP54 PF00448.22 EMC86653.1 - 0.18 11.4 5.8 1.1 8.9 0.7 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain cobW PF02492.19 EMC86653.1 - 0.96 9.0 2.9 13 5.3 0.1 2.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Pkinase PF00069.25 EMC86654.1 - 4.1e-09 36.2 0.0 4.7e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EMC86654.1 - 7e-06 25.1 0.0 9.9e-06 24.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_Tyr PF07714.17 EMC86654.1 - 3e-05 23.4 0.0 3.7e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Cyclin_N PF00134.23 EMC86655.1 - 1.7e-27 95.7 0.3 3.1e-27 94.8 0.3 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EMC86655.1 - 1.3e-11 44.6 0.0 4e-11 43.1 0.0 1.9 1 0 0 1 1 1 1 Cyclin, C-terminal domain DUF4693 PF15764.5 EMC86656.1 - 2e-98 329.5 7.7 2.4e-98 329.2 7.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4693) fn3 PF00041.21 EMC86658.1 - 2.5e-11 43.8 0.2 4.8e-11 42.9 0.2 1.5 1 0 0 1 1 1 1 Fibronectin type III domain Ank_4 PF13637.6 EMC86658.1 - 0.00061 20.3 0.0 0.0013 19.3 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC86658.1 - 0.0045 17.5 0.0 0.0094 16.5 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Pur_ac_phosph_N PF16656.5 EMC86658.1 - 0.0061 17.1 1.8 0.027 15.0 1.8 2.0 1 1 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Ank_5 PF13857.6 EMC86658.1 - 0.02 15.2 0.0 0.045 14.1 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC86658.1 - 0.041 14.4 0.0 5.3 8.0 0.0 2.7 2 0 0 2 2 2 0 Ankyrin repeat Big_5 PF13205.6 EMC86658.1 - 0.07 13.8 0.0 0.16 12.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial Ig-like domain Retrotrans_gag PF03732.17 EMC86659.1 - 0.03 14.6 1.8 0.062 13.6 1.8 1.6 1 1 0 1 1 1 0 Retrotransposon gag protein MHB PF16525.5 EMC86659.1 - 0.087 13.1 0.1 0.25 11.6 0.1 1.8 1 0 0 1 1 1 0 Haemophore, haem-binding DUF3138 PF11336.8 EMC86659.1 - 0.23 10.0 0.0 0.29 9.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) TLD PF07534.16 EMC86661.1 - 1.5e-27 96.5 0.1 1e-25 90.6 0.1 2.3 1 1 0 1 1 1 1 TLD RabGAP-TBC PF00566.18 EMC86661.1 - 4.5e-26 91.8 0.0 6.7e-26 91.3 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain ATP-synt_C PF00137.21 EMC86662.1 - 2.9e-35 120.4 32.3 1.2e-22 80.0 14.1 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Amidohydro_1 PF01979.20 EMC86663.1 - 4.3e-20 72.3 0.9 5.4e-20 72.0 0.9 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EMC86663.1 - 1e-06 28.5 0.2 3.6e-06 26.7 0.0 1.9 2 0 0 2 2 2 1 Amidohydrolase family DUF5616 PF18481.1 EMC86663.1 - 0.085 13.2 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5616) DUF4615 PF15393.6 EMC86664.1 - 1.3e-43 148.9 3.2 1.3e-43 148.9 3.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4615) PP_M1 PF03012.14 EMC86664.1 - 0.1 12.2 5.4 0.15 11.6 5.4 1.3 1 0 0 1 1 1 0 Phosphoprotein NopRA1 PF16201.5 EMC86664.1 - 0.11 12.1 0.1 0.15 11.6 0.1 1.3 1 0 0 1 1 1 0 Nucleolar pre-ribosomal-associated protein 1 PDE4_UCR PF18100.1 EMC86664.1 - 2 9.1 7.2 1.3 9.7 4.7 2.1 1 1 1 2 2 2 0 Phosphodiesterase 4 upstream conserved regions (UCR) Presenilin PF01080.17 EMC86664.1 - 5 5.8 6.6 5.4 5.7 6.6 1.2 1 0 0 1 1 1 0 Presenilin LCE PF14672.6 EMC86665.1 - 0.46 11.1 5.7 38 5.0 0.0 2.2 2 0 0 2 2 2 0 Late cornified envelope SelP_N PF04592.14 EMC86665.1 - 0.72 9.2 11.8 0.85 9.0 11.8 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region LTD PF00932.19 EMC86666.1 - 6.1e-11 42.7 0.0 6.4e-08 32.9 0.0 2.5 2 0 0 2 2 2 2 Lamin Tail Domain NPV_P10 PF05531.12 EMC86667.1 - 0.016 15.7 2.0 0.018 15.5 0.2 1.9 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein RRM_1 PF00076.22 EMC86668.1 - 3.8e-20 71.5 0.0 5.5e-20 71.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EMC86668.1 - 0.00031 20.8 0.0 0.00082 19.4 0.0 1.7 1 0 0 1 1 1 1 Limkain b1 RRM_3 PF08777.11 EMC86668.1 - 0.002 18.1 0.0 0.0051 16.8 0.0 1.7 1 0 0 1 1 1 1 RNA binding motif Nup35_RRM_2 PF14605.6 EMC86668.1 - 0.0023 17.9 0.0 0.0037 17.2 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 EMC86668.1 - 0.0046 16.6 0.0 0.0097 15.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMC86668.1 - 0.0051 16.9 0.0 0.012 15.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif RRM_occluded PF16842.5 EMC86668.1 - 0.0069 16.2 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif Macoilin PF09726.9 EMC86668.1 - 0.02 13.5 24.4 0.028 13.0 24.4 1.1 1 0 0 1 1 1 0 Macoilin family LAP1C PF05609.12 EMC86668.1 - 1.1 8.3 16.5 1.6 7.8 16.5 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) PNISR PF15996.5 EMC86668.1 - 5.6 7.2 18.2 10 6.3 18.2 1.4 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR PI3K_1B_p101 PF10486.9 EMC86668.1 - 9.8 3.8 21.1 13 3.4 21.1 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Telomere_reg-2 PF10193.9 EMC86669.1 - 1.3e-35 122.1 0.6 6e-35 120.0 0.2 2.3 2 0 0 2 2 2 1 Telomere length regulation protein RIX1 PF08167.12 EMC86669.1 - 0.0053 16.5 0.1 0.31 10.8 0.0 3.2 4 0 0 4 4 4 1 rRNA processing/ribosome biogenesis L_HMGIC_fpl PF10242.9 EMC86670.1 - 3.7e-05 24.0 1.0 3.7e-05 24.0 1.0 2.3 1 1 1 2 2 2 1 Lipoma HMGIC fusion partner-like protein Clc-like PF07062.12 EMC86670.1 - 0.00054 19.5 0.1 0.00054 19.5 0.1 2.1 2 1 1 3 3 3 1 Clc-like Claudin_3 PF06653.11 EMC86670.1 - 0.0007 19.6 4.3 0.22 11.4 0.1 2.4 2 0 0 2 2 2 2 Tight junction protein, Claudin-like Claudin_2 PF13903.6 EMC86670.1 - 0.0028 17.5 8.0 0.049 13.4 8.0 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF4418 PF14387.6 EMC86670.1 - 0.0073 16.5 1.5 0.0073 16.5 1.5 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4418) SUR7 PF06687.12 EMC86670.1 - 0.087 12.4 2.9 0.25 11.0 2.9 1.8 1 1 0 1 1 1 0 SUR7/PalI family PulG PF11773.8 EMC86670.1 - 0.11 12.4 0.1 0.25 11.2 0.1 1.7 1 0 0 1 1 1 0 Type II secretory pathway pseudopilin Neurensin PF14927.6 EMC86670.1 - 1.3 8.7 4.8 0.93 9.2 0.5 2.5 1 1 1 2 2 2 0 Neurensin Myb_DNA-bind_7 PF15963.5 EMC86671.1 - 0.0051 16.7 0.2 0.011 15.6 0.2 1.5 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EMC86671.1 - 0.021 15.0 0.1 0.087 13.0 0.1 2.2 1 1 0 1 1 1 0 Myb-like DNA-binding domain JUPITER PF17054.5 EMC86672.1 - 1e-09 38.4 8.8 7e-07 29.0 0.2 3.6 2 1 2 4 4 4 3 Microtubule-Associated protein Jupiter MBDa PF16564.5 EMC86672.1 - 0.0043 17.2 0.2 0.068 13.4 0.1 2.3 2 0 0 2 2 2 1 p55-binding region of Methyl-CpG-binding domain proteins MBD Jnk-SapK_ap_N PF09744.9 EMC86673.1 - 1.1e-39 136.2 12.8 1.1e-39 136.2 12.8 3.7 3 1 0 3 3 3 1 JNK_SAPK-associated protein-1 JIP_LZII PF16471.5 EMC86673.1 - 1.9e-29 101.6 9.7 1.9e-29 101.6 9.7 3.7 4 0 0 4 4 4 1 JNK-interacting protein leucine zipper II Golgin_A5 PF09787.9 EMC86673.1 - 0.0011 18.5 4.9 0.0011 18.5 4.9 2.5 2 0 0 2 2 2 1 Golgin subfamily A member 5 RILP PF11461.8 EMC86673.1 - 0.0017 18.5 6.1 0.024 14.8 0.4 3.3 2 0 0 2 2 2 2 Rab interacting lysosomal protein MRP-S34 PF16053.5 EMC86674.1 - 1.6e-49 166.8 1.0 1.7e-48 163.5 1.0 1.9 1 1 0 1 1 1 1 Mitochondrial 28S ribosomal protein S34 NAD_binding_2 PF03446.15 EMC86675.1 - 6.1e-39 133.7 0.0 1.3e-38 132.6 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EMC86675.1 - 6.9e-23 81.2 1.1 1.2e-22 80.4 1.1 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase PWWP PF00855.17 EMC86675.1 - 9.9e-14 51.5 0.4 9.9e-14 51.5 0.4 1.9 2 0 0 2 2 2 1 PWWP domain F420_oxidored PF03807.17 EMC86675.1 - 9.2e-08 32.6 0.0 2.5e-07 31.2 0.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 EMC86675.1 - 9.1e-05 21.9 0.0 0.00082 18.8 0.0 2.1 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EMC86675.1 - 0.00025 21.1 0.0 0.00048 20.2 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 EMC86675.1 - 0.00037 20.2 0.0 0.0007 19.3 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 EMC86675.1 - 0.0024 17.8 0.0 0.0074 16.2 0.0 1.8 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EMC86675.1 - 0.029 14.6 0.0 0.069 13.4 0.0 1.8 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_Gly3P_dh_N PF01210.23 EMC86675.1 - 0.14 12.1 0.4 0.43 10.5 0.0 1.9 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus AT_hook PF02178.19 EMC86675.1 - 4.2 7.6 11.9 0.097 12.6 4.1 2.6 2 0 0 2 2 2 0 AT hook motif Rogdi_lz PF10259.9 EMC86676.1 - 7.6e-50 169.8 0.1 9.1e-50 169.6 0.1 1.1 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein 7tm_1 PF00001.21 EMC86677.1 - 2.3e-54 184.5 15.4 2.9e-54 184.2 15.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 EMC86677.1 - 1.3e-13 50.9 12.2 5.4e-12 45.6 12.2 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.9 EMC86677.1 - 8.8e-08 31.8 14.2 1.2e-07 31.4 14.1 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 EMC86677.1 - 1.3e-06 28.4 4.5 1.3e-06 28.4 4.5 2.1 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC86677.1 - 0.00044 20.0 18.9 0.00071 19.3 10.4 2.3 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srx Flavi_capsid PF01003.19 EMC86677.1 - 0.16 11.8 0.1 0.28 10.9 0.1 1.4 1 0 0 1 1 1 0 Flavivirus capsid protein C Sigma_reg_N PF13800.6 EMC86677.1 - 0.17 12.2 0.2 0.17 12.2 0.2 3.0 4 1 0 4 4 4 0 Sigma factor regulator N-terminal 7tm_1 PF00001.21 EMC86678.1 - 6.4e-23 81.4 28.4 8.5e-23 81.0 28.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 EMC86678.1 - 1e-08 34.9 28.8 8.4e-05 22.0 28.8 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srx PF10328.9 EMC86678.1 - 1.7e-07 31.2 27.7 1.7e-07 31.2 27.7 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Thioredoxin_6 PF13848.6 EMC86679.1 - 8.3e-08 32.3 0.4 1.3e-07 31.7 0.4 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain HA70_C PF17993.1 EMC86679.1 - 0.065 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Haemagglutinin 70 C-terminal domain AMP-binding PF00501.28 EMC86680.1 - 4.1e-84 282.6 0.0 5.2e-84 282.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMC86680.1 - 4.2e-24 85.3 1.4 8.9e-24 84.3 1.4 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 EMC86681.1 - 8.8e-78 261.8 0.0 1.1e-77 261.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMC86681.1 - 1.3e-23 83.7 0.4 3.4e-23 82.4 0.4 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain THUMP PF02926.17 EMC86682.1 - 2.6e-24 86.0 0.9 4.3e-24 85.3 0.5 1.6 1 1 0 1 1 1 1 THUMP domain AMP-binding PF00501.28 EMC86683.1 - 3.6e-82 276.2 0.0 4.7e-82 275.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMC86683.1 - 4e-24 85.4 2.8 8e-24 84.4 2.1 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain RNase_T PF00929.24 EMC86684.1 - 7.3e-23 81.9 0.0 1e-22 81.4 0.0 1.2 1 0 0 1 1 1 1 Exonuclease RRM_1 PF00076.22 EMC86685.1 - 2.5e-21 75.3 0.0 1.5e-12 47.2 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.24 EMC86685.1 - 3.6e-06 27.6 0.0 1.1e-05 26.0 0.0 1.9 1 0 0 1 1 1 1 Exonuclease Na_H_antiport_3 PF07399.11 EMC86685.1 - 0.041 12.8 0.2 0.059 12.2 0.2 1.1 1 0 0 1 1 1 0 Putative Na+/H+ antiporter Cullin_binding PF03556.15 EMC86686.1 - 5.1e-33 114.1 0.2 9e-33 113.3 0.2 1.4 1 0 0 1 1 1 1 Cullin binding Complex1_LYR PF05347.15 EMC86687.1 - 1.2e-13 50.9 0.1 1.8e-13 50.3 0.1 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EMC86687.1 - 0.012 16.4 0.3 0.016 15.9 0.3 1.4 1 1 0 1 1 1 0 Complex1_LYR-like GP120 PF00516.18 EMC86687.1 - 0.1 11.2 0.1 0.13 10.8 0.1 1.1 1 0 0 1 1 1 0 Envelope glycoprotein GP120 Promethin PF16015.5 EMC86688.1 - 1.3e-22 79.7 13.9 1.6e-22 79.4 13.9 1.1 1 0 0 1 1 1 1 Promethin DUF2207 PF09972.9 EMC86688.1 - 0.028 13.2 1.4 0.035 12.9 1.4 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Zona_pellucida PF00100.23 EMC86689.1 - 7.2e-46 157.1 0.1 1.2e-44 153.1 0.0 2.3 2 0 0 2 2 2 1 Zona pellucida-like domain Ank_2 PF12796.7 EMC86690.1 - 1.7e-17 63.8 0.4 9.8e-13 48.5 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC86690.1 - 5.3e-16 58.5 3.3 4.9e-07 29.9 0.2 3.6 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC86690.1 - 8.8e-16 58.1 0.8 9.5e-06 26.1 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EMC86690.1 - 4.8e-11 42.6 1.3 5.4e-08 32.9 0.4 3.8 4 0 0 4 4 4 1 Ankyrin repeat Ank_3 PF13606.6 EMC86690.1 - 4.2e-10 39.0 0.3 6.1e-05 23.1 0.2 4.3 4 0 0 4 4 4 2 Ankyrin repeat SAM_1 PF00536.30 EMC86690.1 - 3.6e-07 30.5 0.1 8.4e-07 29.3 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ribosomal_S18 PF01084.20 EMC86690.1 - 0.0051 17.0 0.4 0.013 15.7 0.4 1.6 1 0 0 1 1 1 1 Ribosomal protein S18 OCD_Mu_crystall PF02423.15 EMC86691.1 - 2.1e-92 309.5 0.2 2.3e-92 309.3 0.2 1.0 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 EMC86691.1 - 7.8e-09 35.7 0.0 1.3e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EMC86691.1 - 0.00015 22.2 0.0 0.00044 20.8 0.0 1.8 1 1 1 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EMC86691.1 - 0.00018 21.7 0.5 0.0016 18.6 0.4 2.5 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Peptidase_M16 PF00675.20 EMC86692.1 - 5.9e-31 107.5 0.0 9.6e-31 106.8 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EMC86692.1 - 3.8e-23 82.4 0.0 2.8e-22 79.6 0.0 2.1 2 0 0 2 2 2 1 Peptidase M16 inactive domain Atthog PF18800.1 EMC86693.1 - 6.4e-62 207.6 4.3 7.1e-62 207.5 4.3 1.0 1 0 0 1 1 1 1 Attenuator of Hedgehog 7tm_3 PF00003.22 EMC86693.1 - 5.1e-05 23.1 4.7 5.6e-05 23.0 4.7 1.0 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Cyt_bd_oxida_I PF01654.17 EMC86693.1 - 0.00017 20.3 4.0 0.00021 20.1 4.0 1.1 1 0 0 1 1 1 1 Cytochrome bd terminal oxidase subunit I LtrA PF06772.11 EMC86693.1 - 0.0015 17.9 0.5 0.0018 17.6 0.5 1.1 1 0 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) DUF423 PF04241.15 EMC86693.1 - 0.057 13.6 0.9 0.057 13.6 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF423) DUF998 PF06197.13 EMC86693.1 - 0.072 12.7 7.1 0.2 11.2 7.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF998) L_HMGIC_fpl PF10242.9 EMC86693.1 - 0.14 12.3 6.3 0.22 11.7 6.0 1.6 1 1 0 1 1 1 0 Lipoma HMGIC fusion partner-like protein TctB PF07331.11 EMC86693.1 - 0.25 11.6 10.8 0.86 9.9 10.8 1.8 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family DUF3784 PF12650.7 EMC86693.1 - 0.89 9.8 11.7 2.6 8.3 11.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3784) DUF2721 PF11026.8 EMC86693.1 - 1.5 8.7 10.3 1.7 8.6 4.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) DUF456 PF04306.13 EMC86693.1 - 2.4 8.4 11.4 16 5.7 11.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF456) VWA_3 PF13768.6 EMC86694.1 - 0.025 14.5 0.0 0.36 10.8 0.0 2.0 2 0 0 2 2 2 0 von Willebrand factor type A domain 3Beta_HSD PF01073.19 EMC86695.1 - 6.6e-66 222.2 0.0 8.1e-66 221.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EMC86695.1 - 8.2e-32 110.6 0.0 1.1e-31 110.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMC86695.1 - 4.8e-16 59.1 0.0 4.4e-15 55.9 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EMC86695.1 - 7.2e-11 42.3 0.0 1.1e-10 41.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EMC86695.1 - 1.2e-10 41.0 0.0 7.9e-09 35.1 0.0 2.3 1 1 0 2 2 2 1 Male sterility protein RmlD_sub_bind PF04321.17 EMC86695.1 - 2.5e-09 36.7 0.0 3.3e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EMC86695.1 - 4.6e-08 32.5 0.7 2.2e-07 30.3 0.4 2.2 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein NmrA PF05368.13 EMC86695.1 - 3.2e-05 23.6 0.0 4.4e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 EMC86695.1 - 0.011 15.2 0.0 0.019 14.4 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase SWI2_SNF2 PF18766.1 EMC86695.1 - 0.16 11.6 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 SWI2/SNF2 ATPase 3Beta_HSD PF01073.19 EMC86696.1 - 3.8e-65 219.7 0.0 4.8e-65 219.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EMC86696.1 - 1.6e-26 93.3 0.0 2.1e-26 92.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMC86696.1 - 1.5e-11 44.3 0.0 3.6e-11 43.1 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EMC86696.1 - 5.4e-10 38.8 0.0 7.5e-10 38.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EMC86696.1 - 3.1e-07 30.5 0.0 4.2e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EMC86696.1 - 3.1e-07 29.8 0.3 1.7e-06 27.4 0.3 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EMC86696.1 - 3e-06 26.6 0.0 8.4e-06 25.1 0.0 1.7 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 EMC86696.1 - 7.8e-05 22.3 0.0 0.00017 21.3 0.0 1.6 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 EMC86696.1 - 0.0041 16.6 0.0 0.0062 16.0 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Alpha_kinase PF02816.18 EMC86697.1 - 1.9e-60 204.1 0.2 3e-60 203.5 0.2 1.3 1 0 0 1 1 1 1 Alpha-kinase family Sel1 PF08238.12 EMC86697.1 - 6.9e-09 36.1 7.8 0.0032 18.1 0.1 5.1 5 0 0 5 5 5 3 Sel1 repeat Sin_N PF04801.13 EMC86698.1 - 6.7e-156 519.8 2.7 6.7e-156 519.8 2.7 2.5 3 0 0 3 3 3 1 Sin-like protein conserved region PID_2 PF14719.6 EMC86698.1 - 0.11 12.4 0.7 0.36 10.7 0.5 1.8 2 0 0 2 2 2 0 Phosphotyrosine interaction domain (PTB/PID) DUF2120 PF09893.9 EMC86698.1 - 0.2 11.8 1.1 0.48 10.5 1.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) ATG13 PF10033.9 EMC86698.1 - 0.46 10.1 2.9 0.16 11.6 0.2 1.6 2 0 0 2 2 2 0 Autophagy-related protein 13 PRKCSH_1 PF13015.6 EMC86699.1 - 4.1e-10 39.6 0.4 2.9e-09 36.8 0.0 2.2 1 1 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 EMC86699.1 - 1.3e-07 32.5 3.0 1.3e-07 32.5 3.0 2.0 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein VP_N-CPKC PF11475.8 EMC86699.1 - 0.027 14.4 1.4 0.9 9.5 0.1 2.7 2 0 0 2 2 2 0 Virion protein N terminal domain Syntaxin-18_N PF10496.9 EMC86699.1 - 0.057 13.7 1.3 0.1 12.9 1.3 1.3 1 0 0 1 1 1 0 SNARE-complex protein Syntaxin-18 N-terminus DPM3 PF08285.11 EMC86699.1 - 0.13 12.4 0.1 0.24 11.6 0.1 1.4 1 0 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Ribo_biogen_C PF04034.13 EMC86700.1 - 3.2e-53 178.8 0.0 4.3e-53 178.4 0.0 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 EMC86700.1 - 8.4e-13 47.9 1.3 1.6e-12 47.0 1.3 1.5 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI UQ_con PF00179.26 EMC86701.1 - 2.1e-49 166.8 0.0 2.4e-49 166.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EMC86701.1 - 4.3e-05 23.2 0.0 4.9e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B Pkinase PF00069.25 EMC86702.1 - 1.4e-66 224.6 0.0 1.7e-66 224.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain PH_3 PF14593.6 EMC86702.1 - 1.8e-42 143.6 0.0 3.5e-42 142.7 0.0 1.5 1 0 0 1 1 1 1 PH domain Pkinase_Tyr PF07714.17 EMC86702.1 - 2.1e-34 119.0 0.0 2.9e-34 118.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC86702.1 - 1.1e-06 28.2 0.0 1.9e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMC86702.1 - 1.7e-05 23.8 0.0 2.5e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EMC86702.1 - 3.1e-05 23.1 0.1 4.6e-05 22.5 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EMC86702.1 - 0.00017 21.6 0.1 0.023 14.6 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 EMC86702.1 - 0.0015 18.2 0.0 1.5 8.4 0.0 2.3 1 1 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EMC86702.1 - 0.0066 15.8 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family fn3 PF00041.21 EMC86703.1 - 0.025 14.9 0.1 0.04 14.3 0.1 1.4 1 1 0 1 1 1 0 Fibronectin type III domain DUF1736 PF08409.11 EMC86703.1 - 0.056 13.4 0.2 0.11 12.6 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1736) EpoR_lig-bind PF09067.10 EMC86704.1 - 7.1e-05 23.0 0.7 0.00021 21.5 0.7 1.7 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding Pur_ac_phosph_N PF16656.5 EMC86704.1 - 0.00029 21.3 1.1 0.0025 18.3 0.2 2.3 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain fn3 PF00041.21 EMC86704.1 - 0.00039 20.7 1.7 0.00064 20.0 0.4 2.1 2 1 0 2 2 2 1 Fibronectin type III domain IL2RB_N1 PF18707.1 EMC86704.1 - 0.14 12.7 1.4 0.83 10.2 1.4 2.2 1 1 0 1 1 1 0 Interleukin-2 receptor subunit beta N-terminal domain 1 IL4Ra_N PF09238.10 EMC86705.1 - 1.5e-28 99.0 1.1 1.5e-28 99.0 1.1 2.0 2 1 0 2 2 2 1 Interleukin-4 receptor alpha chain, N-terminal fn3 PF00041.21 EMC86705.1 - 5.1e-05 23.5 0.2 0.00084 19.6 0.6 2.2 2 0 0 2 2 2 1 Fibronectin type III domain IL6Ra-bind PF09240.10 EMC86705.1 - 0.0075 16.7 0.6 0.014 15.8 0.6 1.5 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding EpoR_lig-bind PF09067.10 EMC86705.1 - 0.0093 16.2 0.9 0.0093 16.2 0.9 1.9 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding SMC_Nse1 PF07574.13 EMC86706.1 - 2e-27 96.4 0.9 7.6e-26 91.2 0.9 2.0 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 EMC86706.1 - 2e-07 31.2 13.5 2e-07 31.2 13.5 2.5 3 0 0 3 3 3 1 RING-like domain YjcZ PF13990.6 EMC86706.1 - 0.13 11.6 0.0 0.17 11.3 0.0 1.1 1 0 0 1 1 1 0 YjcZ-like protein zf-C3HC4 PF00097.25 EMC86706.1 - 4.3 7.3 16.2 2.3 8.2 13.7 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Cupin_8 PF13621.6 EMC86707.1 - 4.3e-46 157.7 0.0 5.4e-46 157.4 0.0 1.0 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 EMC86707.1 - 2.8e-07 30.3 0.1 6.6e-07 29.1 0.1 1.5 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 EMC86707.1 - 0.023 15.2 0.1 0.084 13.3 0.1 1.9 1 1 0 1 1 1 0 JmjC domain, hydroxylase Sulfotransfer_1 PF00685.27 EMC86708.1 - 1.5e-42 145.9 0.0 1.9e-42 145.6 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC86708.1 - 1.7e-13 51.5 0.0 6e-11 43.1 0.0 2.2 1 1 1 2 2 2 2 Sulfotransferase family Sulfotransfer_2 PF03567.14 EMC86708.1 - 0.003 17.5 0.1 0.064 13.2 0.0 2.1 2 0 0 2 2 2 1 Sulfotransferase family UCH PF00443.29 EMC86709.1 - 1.3e-38 133.0 0.0 3.6e-38 131.5 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMC86709.1 - 7.6e-10 38.9 0.1 1.4e-05 24.8 0.1 3.0 2 1 1 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase zinc_ribbon_10 PF10058.9 EMC86709.1 - 0.034 13.9 0.6 14 5.5 0.1 2.8 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein GGACT PF06094.12 EMC86709.1 - 0.052 14.1 0.0 0.1 13.2 0.0 1.4 1 0 0 1 1 1 0 Gamma-glutamyl cyclotransferase, AIG2-like Zn_Tnp_IS1595 PF12760.7 EMC86709.1 - 0.48 10.4 4.1 9.7 6.3 0.0 3.1 3 0 0 3 3 3 0 Transposase zinc-ribbon domain ASC PF00858.24 EMC86710.1 - 1e-111 374.1 6.7 1.4e-111 373.6 6.7 1.2 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Toxin_TOLIP PF00087.21 EMC86710.1 - 0.012 15.9 1.9 0.037 14.3 1.9 1.8 1 0 0 1 1 1 0 Snake toxin and toxin-like protein DAAD PF18752.1 EMC86710.1 - 0.025 14.4 0.0 0.039 13.8 0.0 1.2 1 0 0 1 1 1 0 Dictyosteliid AID/APOBEC-like Deaminase tRNA-synt_1c PF00749.21 EMC86711.1 - 1.5e-80 270.5 0.0 2.4e-80 269.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain LexA_DNA_bind PF01726.16 EMC86711.1 - 0.092 12.5 0.0 0.54 10.1 0.0 2.2 2 0 0 2 2 2 0 LexA DNA binding domain ubiquitin PF00240.23 EMC86712.1 - 9e-11 41.4 0.0 1.8e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 EMC86712.1 - 0.0031 17.9 0.1 0.024 15.1 0.0 2.4 1 1 1 2 2 2 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EMC86712.1 - 0.014 15.8 0.0 0.026 14.9 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain Pkinase PF00069.25 EMC86713.1 - 1.7e-08 34.2 0.0 1.9e-08 34.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC86713.1 - 0.00032 20.1 0.0 0.00036 19.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3974 PF13120.6 EMC86713.1 - 0.084 13.0 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3974) Pkinase PF00069.25 EMC86714.1 - 2.2e-45 155.1 0.0 3.3e-45 154.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain POLO_box PF00659.18 EMC86714.1 - 2.5e-43 146.1 1.2 3.2e-21 75.3 0.6 2.4 2 0 0 2 2 2 2 POLO box duplicated region Pkinase_Tyr PF07714.17 EMC86714.1 - 3.5e-25 88.8 0.0 5.1e-25 88.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC86714.1 - 2.3e-06 26.7 0.0 3.1e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EMC86714.1 - 4.3e-05 23.0 0.0 6.3e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Hexapep PF00132.24 EMC86715.1 - 7e-16 57.2 22.7 4.7e-06 26.1 2.9 4.3 3 1 2 5 5 5 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EMC86715.1 - 0.00013 21.6 9.5 0.0043 16.8 0.5 3.9 3 2 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 EMC86715.1 - 0.0078 14.4 0.3 0.0093 14.1 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Fucokinase PF07959.12 EMC86715.1 - 0.039 12.9 1.7 0.063 12.2 0.3 1.7 1 1 1 2 2 2 0 L-fucokinase PALB2_WD40 PF16756.5 EMC86716.1 - 1.3e-170 567.0 0.2 1.6e-170 566.7 0.2 1.1 1 0 0 1 1 1 1 Partner and localizer of BRCA2 WD40 domain PP-binding PF00550.25 EMC86717.1 - 7.2e-12 45.5 0.0 7.8e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 EMC86717.1 - 0.00063 19.9 0.2 0.0007 19.8 0.2 1.1 1 0 0 1 1 1 1 Acyl-carrier GAIN_A PF18619.1 EMC86718.1 - 0.11 12.8 0.1 0.13 12.5 0.1 1.1 1 0 0 1 1 1 0 GPCR-Autoproteolysis-INducing (GAIN) subdomain A DUF3367 PF11847.8 EMC86718.1 - 0.13 10.1 0.0 0.13 10.1 0.0 1.0 1 0 0 1 1 1 0 Alpha-(1->3)-arabinofuranosyltransferase TNRC6-PABC_bdg PF16608.5 EMC86719.1 - 1.8e-120 402.1 32.9 1.8e-120 402.1 32.9 7.8 7 1 0 7 7 7 1 TNRC6-PABC binding domain Ago_hook PF10427.9 EMC86719.1 - 3.4e-15 57.0 16.4 3.4e-15 57.0 16.4 11.2 3 2 4 8 8 8 1 Argonaute hook RRM_1 PF00076.22 EMC86719.1 - 0.0014 18.4 0.0 0.0033 17.2 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PMP22_Claudin PF00822.20 EMC86720.1 - 3.3e-33 114.9 0.6 4.6e-33 114.4 0.6 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC86720.1 - 4.5e-09 36.3 0.5 8.4e-09 35.5 0.6 1.4 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Pkinase_C PF00433.24 EMC86721.1 - 7.7e-11 42.5 1.5 1e-10 42.2 1.5 1.2 1 0 0 1 1 1 1 Protein kinase C terminal domain MIP PF00230.20 EMC86722.1 - 1.8e-48 165.2 11.8 2.4e-48 164.8 11.8 1.1 1 0 0 1 1 1 1 Major intrinsic protein LCM PF04072.14 EMC86723.1 - 7e-23 81.5 0.0 9.4e-23 81.1 0.0 1.2 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Filament PF00038.21 EMC86725.1 - 6.4e-56 190.2 15.6 8.3e-55 186.6 15.6 2.0 1 1 0 1 1 1 1 Intermediate filament protein DUF4407 PF14362.6 EMC86725.1 - 0.00032 20.1 0.2 0.00039 19.9 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) DUF5344 PF17279.2 EMC86725.1 - 0.002 18.7 0.5 0.79 10.3 0.3 2.5 2 0 0 2 2 2 1 Family of unknown function (DUF5344) DUF4618 PF15397.6 EMC86725.1 - 0.02 14.3 11.1 0.3 10.5 1.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4618) Phage_Mu_Gam PF07352.12 EMC86725.1 - 0.027 14.4 6.2 0.29 11.0 0.1 2.3 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein FAM184 PF15665.5 EMC86725.1 - 0.031 14.1 6.4 0.079 12.7 3.7 2.4 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B Erp_C PF06780.11 EMC86725.1 - 0.045 13.8 0.0 0.079 13.0 0.0 1.6 1 0 0 1 1 1 0 Erp protein C-terminus T7SS_ESX_EspC PF10824.8 EMC86725.1 - 0.14 12.6 0.0 2.3 8.7 0.0 2.2 2 0 0 2 2 2 0 Excreted virulence factor EspC, type VII ESX diderm DUF1640 PF07798.11 EMC86725.1 - 0.29 11.2 10.1 0.075 13.1 5.9 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1640) DUF1192 PF06698.11 EMC86725.1 - 0.62 10.2 8.1 1.5 8.9 0.9 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) CLZ PF16526.5 EMC86725.1 - 0.99 9.8 8.9 0.13 12.6 1.6 2.9 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels YabA PF06156.13 EMC86725.1 - 1.2 9.8 5.4 1.8 9.2 1.9 2.8 3 1 0 3 3 3 0 Initiation control protein YabA BLI1 PF17324.2 EMC86725.1 - 1.4 9.6 6.2 3.1 8.5 0.7 2.9 3 0 0 3 3 3 0 BLOC-1 interactor 1 BLOC1_2 PF10046.9 EMC86725.1 - 1.5 9.1 6.8 1.2 9.5 1.5 2.6 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 OmpH PF03938.14 EMC86725.1 - 2.1 8.7 8.5 0.58 10.5 3.2 2.3 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) UPF0242 PF06785.11 EMC86725.1 - 2.2 8.4 10.0 0.082 13.0 0.6 2.6 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Cep57_MT_bd PF06657.13 EMC86725.1 - 3.5 8.2 12.4 1.5 9.3 5.0 3.4 2 2 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 BRE1 PF08647.11 EMC86725.1 - 8.6 6.5 14.2 0.44 10.6 3.8 3.4 3 2 0 3 3 3 0 BRE1 E3 ubiquitin ligase Tubulin_C PF03953.17 EMC86726.1 - 2.6e-52 176.3 0.0 4.7e-52 175.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 EMC86726.1 - 3.8e-43 148.0 0.0 5.3e-43 147.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 EMC86726.1 - 0.13 11.5 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Tubulin like Herpes_UL43 PF05072.13 EMC86730.1 - 0.37 9.9 2.2 1.1e+02 1.7 0.0 3.9 1 1 3 4 4 4 0 Herpesvirus UL43 protein DUF1937 PF09152.10 EMC86730.1 - 1.8 9.4 10.8 1.4e+02 3.3 0.1 5.1 2 1 4 6 6 6 0 Domain of unknown function (DUF1937) V-set PF07686.17 EMC86731.1 - 2.6e-12 46.9 0.0 3.1e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC86731.1 - 6.3e-08 33.1 0.0 9.1e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC86731.1 - 3.1e-07 30.4 0.0 7.9e-07 29.1 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC86731.1 - 0.0007 19.7 0.0 0.0015 18.7 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC86731.1 - 0.012 16.0 0.0 0.046 14.1 0.0 1.8 1 1 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 EMC86732.1 - 4e-13 49.5 0.0 4.9e-13 49.2 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC86732.1 - 2.3e-07 31.3 0.0 3.5e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC86732.1 - 5.1e-07 29.7 0.0 9.4e-07 28.8 0.0 1.4 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC86732.1 - 0.0001 22.4 0.0 0.00018 21.6 0.0 1.4 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC86732.1 - 0.01 16.1 0.0 0.03 14.6 0.0 1.9 1 1 0 1 1 1 0 Immunoglobulin domain mCpol PF18182.1 EMC86732.1 - 0.11 12.8 0.0 0.24 11.7 0.0 1.5 1 1 0 1 1 1 0 minimal CRISPR polymerase domain PI3_PI4_kinase PF00454.27 EMC86735.1 - 5.9e-18 65.6 0.1 7.1e-18 65.3 0.1 1.1 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 EMC86736.1 - 1.3e-14 53.7 0.2 1.7e-14 53.3 0.2 1.2 1 0 0 1 1 1 1 FATC domain DUF1263 PF06882.12 EMC86736.1 - 0.037 14.1 0.0 0.046 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1263) CDP-OH_P_transf PF01066.21 EMC86737.1 - 5.5e-16 59.1 0.3 5.5e-16 59.1 0.3 3.3 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Integrase_H2C2 PF17921.1 EMC86738.1 - 0.00019 21.5 3.5 0.0011 19.0 0.2 2.5 2 1 0 2 2 2 1 Integrase zinc binding domain BEN PF10523.9 EMC86738.1 - 0.008 16.4 0.3 0.29 11.4 0.0 2.8 2 0 0 2 2 2 1 BEN domain DUF1664 PF07889.12 EMC86739.1 - 0.91 9.6 5.3 0.27 11.3 0.4 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Noelin-1 PF12308.8 EMC86739.1 - 1.5 8.8 5.3 1.2 9.2 0.6 2.6 2 1 0 3 3 3 0 Neurogenesis glycoprotein Spc7 PF08317.11 EMC86740.1 - 0.011 14.7 5.8 0.011 14.6 5.8 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein PDT PF00800.18 EMC86740.1 - 0.13 12.1 0.2 0.25 11.1 0.2 1.6 1 1 0 1 1 1 0 Prephenate dehydratase 7TMR-HDED PF07697.11 EMC86740.1 - 0.14 12.3 2.0 0.14 12.2 2.0 1.1 1 0 0 1 1 1 0 7TM-HD extracellular Cnn_1N PF07989.11 EMC86740.1 - 0.19 11.9 6.3 3.7 7.8 1.3 2.5 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 GIT_CC PF16559.5 EMC86740.1 - 0.59 10.0 5.9 0.21 11.5 0.9 2.3 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor YabA PF06156.13 EMC86740.1 - 2.5 8.8 7.2 12 6.5 0.9 2.1 1 1 1 2 2 2 0 Initiation control protein YabA Collagen PF01391.18 EMC86741.1 - 4.7e-42 141.6 161.4 1.3e-09 37.6 26.4 6.2 3 1 3 6 6 6 6 Collagen triple helix repeat (20 copies) VWA PF00092.28 EMC86741.1 - 1.6e-39 136.0 0.2 9.8e-19 68.3 0.1 2.6 3 0 0 3 3 3 2 von Willebrand factor type A domain VWA_2 PF13519.6 EMC86741.1 - 4.7e-13 49.7 0.1 7.2e-07 29.8 0.0 2.6 2 1 0 2 2 2 2 von Willebrand factor type A domain Kunitz_BPTI PF00014.23 EMC86742.1 - 1.1e-18 67.2 9.4 1.2e-18 67.1 9.4 1.0 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain TMEM108 PF15759.5 EMC86743.1 - 2.1e-58 198.6 12.3 2.5e-58 198.4 12.3 1.0 1 0 0 1 1 1 1 TMEM108 family ThiF PF00899.21 EMC86744.1 - 1.8e-49 168.3 0.1 2.4e-49 167.9 0.1 1.1 1 0 0 1 1 1 1 ThiF family UDPG_MGDP_dh_N PF03721.14 EMC86744.1 - 0.0009 18.9 0.0 0.0016 18.1 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 EMC86744.1 - 0.052 12.9 0.2 0.15 11.4 0.0 1.8 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 EMC86744.1 - 0.055 13.9 0.0 0.16 12.5 0.0 1.8 1 0 0 1 1 1 0 Putative NAD(P)-binding ApbA PF02558.16 EMC86744.1 - 0.14 11.8 0.1 0.61 9.7 0.1 2.0 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.19 EMC86744.1 - 0.16 11.2 0.3 0.25 10.5 0.3 1.3 1 0 0 1 1 1 0 FAD binding domain Sacchrp_dh_NADP PF03435.18 EMC86744.1 - 0.61 10.3 6.6 0.47 10.7 0.6 2.8 3 1 0 3 3 3 0 Saccharopine dehydrogenase NADP binding domain APH PF01636.23 EMC86745.1 - 2.1e-46 158.8 0.1 3.7e-46 158.0 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Acyl-CoA_dh_1 PF00441.24 EMC86745.1 - 1.9e-34 119.0 1.1 3.1e-34 118.3 1.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EMC86745.1 - 7e-19 67.8 0.0 1.2e-18 67.1 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EMC86745.1 - 2.7e-13 50.3 0.3 1e-12 48.4 0.5 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EMC86745.1 - 6.8e-13 49.3 0.2 1.6e-12 48.1 0.1 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain EcKinase PF02958.20 EMC86745.1 - 0.0022 17.4 0.0 0.0047 16.3 0.0 1.5 1 0 0 1 1 1 1 Ecdysteroid kinase HpaB_N PF11794.8 EMC86745.1 - 0.0098 15.6 0.0 0.02 14.5 0.0 1.5 1 0 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal RIO1 PF01163.22 EMC86745.1 - 0.014 15.0 0.0 1.1 8.8 0.0 2.4 2 0 0 2 2 2 0 RIO1 family Astro_capsid_p2 PF16580.5 EMC86745.1 - 0.19 11.1 0.0 1.6 8.1 0.0 2.1 2 0 0 2 2 2 0 C-terminal tail of astrovirus capsid projection or spike 7tm_1 PF00001.21 EMC86746.1 - 2.9e-50 171.0 17.2 3.7e-50 170.7 17.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC86746.1 - 7.3e-07 28.8 16.0 9.7e-07 28.4 16.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF621 PF04789.15 EMC86746.1 - 0.045 12.9 9.7 0.014 14.5 6.6 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF621) SirB PF04247.12 EMC86746.1 - 0.12 12.4 5.5 0.055 13.6 1.6 2.2 2 0 0 2 2 2 0 Invasion gene expression up-regulator, SirB Adaptin_N PF01602.20 EMC86747.1 - 0.0032 16.1 1.8 0.77 8.2 0.2 2.6 2 1 0 2 2 2 2 Adaptin N terminal region V-ATPase_H_C PF11698.8 EMC86747.1 - 0.062 13.4 0.7 1.6 8.9 0.0 3.2 2 2 2 4 4 4 0 V-ATPase subunit H DUF383 PF04063.14 EMC86747.1 - 0.072 12.7 1.5 6.3 6.4 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF383) DUF3361 PF11841.8 EMC86747.1 - 0.22 11.5 4.6 0.76 9.7 0.7 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF3361) Utp12 PF04003.12 EMC86747.1 - 0.31 11.4 5.4 18 5.7 0.1 4.1 3 1 0 3 3 3 0 Dip2/Utp12 Family Arm_2 PF04826.13 EMC86747.1 - 0.5 9.8 7.3 0.36 10.2 0.8 2.7 2 1 0 2 2 2 0 Armadillo-like HEAT PF02985.22 EMC86747.1 - 7 7.2 6.0 6 7.4 0.0 4.1 6 0 0 6 6 6 0 HEAT repeat His_Phos_2 PF00328.22 EMC86749.1 - 1.8e-35 123.0 1.4 6.5e-34 117.9 1.4 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) His_Phos_2 PF00328.22 EMC86750.1 - 5.5e-20 72.1 4.4 1.9e-15 57.1 1.4 3.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) Copine PF07002.16 EMC86751.1 - 1.9e-95 318.4 0.0 2.7e-95 318.0 0.0 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 EMC86751.1 - 1.9e-27 95.6 0.1 1.2e-13 51.2 0.1 2.3 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 EMC86751.1 - 3.3e-05 24.1 0.0 5.7e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 EMC86751.1 - 0.00061 20.1 0.0 0.0012 19.2 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Pkinase PF00069.25 EMC86752.1 - 2.6e-59 200.7 0.1 5.4e-59 199.7 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC86752.1 - 8.8e-44 149.7 0.0 1.4e-43 149.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EMC86752.1 - 0.011 15.6 0.1 0.042 13.8 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EMC86752.1 - 0.012 14.5 0.6 0.023 13.5 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase DHR10 PF18595.1 EMC86752.1 - 0.85 9.7 10.2 1.9 8.6 10.2 1.6 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain Pkinase PF00069.25 EMC86755.1 - 2.6e-19 69.6 0.0 2.9e-12 46.5 0.0 2.8 3 0 0 3 3 3 2 Protein kinase domain WD40 PF00400.32 EMC86755.1 - 1.9e-13 50.7 16.5 4.6e-05 24.1 0.3 6.6 6 0 0 6 6 6 3 WD domain, G-beta repeat HEAT PF02985.22 EMC86755.1 - 4.2e-09 35.9 0.4 0.72 10.3 0.0 5.5 6 0 0 6 6 6 3 HEAT repeat Pkinase_Tyr PF07714.17 EMC86755.1 - 3e-06 26.7 0.0 2.4e-05 23.7 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase ANAPC4_WD40 PF12894.7 EMC86755.1 - 0.00011 22.5 0.3 0.56 10.5 0.0 4.4 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 EMC86755.1 - 0.067 11.9 0.2 11 4.6 0.0 3.1 3 0 0 3 3 3 0 Nup133 N terminal like HEAT_2 PF13646.6 EMC86755.1 - 0.072 13.5 0.2 2.9 8.4 0.0 3.3 3 2 0 3 3 3 0 HEAT repeats SGP PF17228.2 EMC86756.1 - 0.24 12.3 10.2 0.38 11.6 5.1 2.2 1 1 1 2 2 2 0 Sulphur globule protein Urm1 PF09138.11 EMC86758.1 - 1.9e-37 127.5 0.0 2e-37 127.4 0.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 EMC86758.1 - 0.001 19.7 0.0 0.0012 19.5 0.0 1.1 1 0 0 1 1 1 1 ThiS family AMP-binding PF00501.28 EMC86760.1 - 8.6e-66 222.3 0.0 1e-65 222.0 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMC86760.1 - 0.0078 17.2 0.0 0.014 16.4 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Coq4 PF05019.13 EMC86761.1 - 9.6e-96 319.4 0.0 1.1e-95 319.2 0.0 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 LAB_N PF07578.11 EMC86761.1 - 0.22 11.6 0.0 0.48 10.6 0.0 1.5 1 0 0 1 1 1 0 Lipid A Biosynthesis N-terminal domain 7tm_1 PF00001.21 EMC86762.1 - 1.9e-17 63.5 3.2 2.1e-17 63.3 3.2 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC86762.1 - 0.036 13.5 3.2 0.038 13.4 3.2 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx LRR_8 PF13855.6 EMC86764.1 - 1e-50 169.3 21.2 1.7e-16 59.7 1.1 5.3 2 1 2 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EMC86764.1 - 8.9e-23 80.0 17.3 7e-06 26.3 0.5 6.3 5 1 1 6 6 6 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC86764.1 - 1.2e-19 70.5 0.0 1.2e-09 38.2 0.0 2.9 1 1 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC86764.1 - 1.1e-13 51.0 1.6 9.5e-06 25.2 0.5 3.2 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 EMC86764.1 - 5.5e-11 41.4 17.9 0.59 10.9 0.2 10.1 9 2 0 9 9 9 2 Leucine Rich Repeat LRR_6 PF13516.6 EMC86764.1 - 2.7e-09 36.3 14.1 2 8.7 0.0 8.5 9 0 0 9 9 9 3 Leucine Rich repeat LRRNT PF01462.18 EMC86764.1 - 0.00084 18.9 1.5 0.00084 18.9 1.5 2.7 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_12 PF18837.1 EMC86764.1 - 0.0039 16.8 1.4 0.23 11.2 0.0 3.4 4 0 0 4 4 4 1 Leucine-rich repeat HemY_N PF07219.13 EMC86764.1 - 0.0074 16.5 0.3 0.013 15.7 0.3 1.4 1 0 0 1 1 1 1 HemY protein N-terminus UL97 PF06734.12 EMC86764.1 - 0.02 14.8 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 UL97 SARAF PF06682.12 EMC86764.1 - 0.046 13.4 0.3 0.88 9.2 0.1 2.1 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Ni_hydr_CYTB PF01292.20 EMC86764.1 - 0.1 12.2 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 DUF4519 PF15012.6 EMC86764.1 - 5.2 7.3 5.3 1.4 9.1 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) Vinculin PF01044.19 EMC86765.1 - 3.3e-15 55.5 0.4 3.8e-15 55.3 0.4 1.0 1 0 0 1 1 1 1 Vinculin family CRISPR_Cse1 PF09481.10 EMC86765.1 - 0.027 13.6 0.0 0.027 13.5 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein Cse1 (CRISPR_cse1) CorA PF01544.18 EMC86765.1 - 0.087 12.1 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein 7tm_1 PF00001.21 EMC86767.1 - 6.3e-79 265.0 12.2 7.6e-79 264.7 12.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC86767.1 - 7.2e-18 64.9 6.2 1.3e-17 64.0 6.2 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC86767.1 - 4.3e-06 26.7 14.6 3.6e-05 23.7 7.3 3.0 3 0 0 3 3 3 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC86767.1 - 5.9e-06 26.1 13.9 5.9e-06 26.1 13.9 2.2 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Amino_oxidase PF01593.24 EMC86768.1 - 5.3e-80 269.9 0.0 7.4e-80 269.4 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EMC86768.1 - 4.2e-15 55.7 0.6 8.7e-15 54.7 0.6 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMC86768.1 - 4.2e-06 26.6 0.0 6.2e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMC86768.1 - 1.2e-05 24.6 1.5 1.9e-05 24.0 1.5 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EMC86768.1 - 0.00019 21.9 1.1 0.00068 20.2 0.5 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMC86768.1 - 0.00039 19.8 0.0 0.00094 18.5 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMC86768.1 - 0.0035 16.1 0.4 0.0082 14.9 0.4 1.7 1 1 0 1 1 1 1 HI0933-like protein GIDA PF01134.22 EMC86768.1 - 0.0046 16.1 0.7 0.0073 15.4 0.7 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EMC86768.1 - 0.0081 15.5 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Shikimate_DH PF01488.20 EMC86768.1 - 0.01 15.9 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Thi4 PF01946.17 EMC86768.1 - 0.011 15.0 0.1 0.022 14.0 0.1 1.4 1 0 0 1 1 1 0 Thi4 family FAD_binding_3 PF01494.19 EMC86768.1 - 0.013 14.8 1.9 0.013 14.8 0.5 1.6 2 0 0 2 2 2 0 FAD binding domain Pyr_redox_3 PF13738.6 EMC86768.1 - 0.013 14.7 0.1 0.023 13.9 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EMC86768.1 - 0.014 14.8 0.6 0.019 14.3 0.6 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase FMO-like PF00743.19 EMC86768.1 - 0.05 12.0 0.0 0.074 11.5 0.0 1.1 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like Lycopene_cycl PF05834.12 EMC86768.1 - 0.056 12.5 0.7 0.22 10.5 0.3 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 EMC86768.1 - 0.061 13.3 0.6 0.16 11.9 0.3 1.8 2 0 0 2 2 2 0 FAD-NAD(P)-binding 3HCDH_N PF02737.18 EMC86768.1 - 0.23 11.4 1.1 6.1 6.7 0.3 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain zf-RING_11 PF17123.5 EMC86769.1 - 3.1e-09 36.4 2.7 6e-09 35.5 2.7 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 EMC86769.1 - 1.6e-05 25.2 2.6 2.8e-05 24.3 2.6 1.5 1 0 0 1 1 1 1 Ring finger domain Prok-RING_1 PF14446.6 EMC86769.1 - 0.0016 18.3 1.6 0.0026 17.6 1.6 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 zf-C3HC4 PF00097.25 EMC86769.1 - 0.0035 17.2 2.8 0.0068 16.3 2.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC86769.1 - 0.0049 16.7 2.2 0.0097 15.7 2.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC86769.1 - 0.0097 15.9 2.7 0.017 15.2 2.7 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMC86769.1 - 0.017 15.1 2.1 0.028 14.4 2.1 1.4 1 0 0 1 1 1 0 zinc-RING finger domain Orthoreo_P10 PF07204.11 EMC86769.1 - 0.027 14.4 0.6 0.039 13.9 0.6 1.3 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 LapA_dom PF06305.11 EMC86769.1 - 0.13 12.1 0.1 0.18 11.6 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Fumble PF03630.14 EMC86770.1 - 1.2e-74 251.5 0.0 1.4e-74 251.3 0.0 1.0 1 0 0 1 1 1 1 Fumble CARD_2 PF16739.5 EMC86771.1 - 1.1e-13 51.0 0.0 1.8e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 Caspase recruitment domain Y_phosphatase PF00102.27 EMC86772.1 - 2.3e-166 551.0 10.0 6.7e-86 287.7 0.8 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 EMC86772.1 - 1.1e-09 38.2 0.1 0.0009 19.1 0.0 2.7 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC86772.1 - 1.4e-08 35.0 0.4 0.00059 19.9 0.0 2.8 2 1 1 3 3 3 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EMC86772.1 - 3.3e-07 30.6 0.7 0.0041 17.3 0.1 3.3 3 0 0 3 3 3 2 Inositol hexakisphosphate TMEM154 PF15102.6 EMC86772.1 - 0.00021 21.2 0.1 0.00021 21.2 0.1 2.1 2 1 0 2 2 2 1 TMEM154 protein family RIFIN PF02009.16 EMC86772.1 - 0.055 13.3 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Rifin Orf78 PF06024.12 EMC86772.1 - 0.058 13.7 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 Orf78 (ac78) DUF2207 PF09972.9 EMC86772.1 - 0.097 11.4 0.0 0.25 10.1 0.0 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Y_phosphatase2 PF03162.13 EMC86772.1 - 0.23 11.0 2.1 3.3 7.3 0.0 3.1 3 0 0 3 3 3 0 Tyrosine phosphatase family Adeno_E3_CR2 PF02439.15 EMC86772.1 - 2.6 7.9 6.9 2.4 8.0 2.6 2.5 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 MRP-S26 PF14943.6 EMC86774.1 - 2.8e-29 102.2 12.3 3.1e-29 102.0 12.3 1.0 1 0 0 1 1 1 1 Mitochondrial ribosome subunit S26 DUF4527 PF15030.6 EMC86774.1 - 0.0066 15.9 3.6 0.007 15.8 3.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4527) ERM PF00769.19 EMC86774.1 - 0.027 14.3 11.5 0.027 14.3 11.5 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Cast PF10174.9 EMC86774.1 - 0.04 12.2 10.2 0.043 12.1 10.2 1.0 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone APG6_N PF17675.1 EMC86774.1 - 0.086 13.4 12.9 0.096 13.2 12.9 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF641 PF04859.12 EMC86774.1 - 0.087 13.2 7.3 0.097 13.0 7.3 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) dCache_1 PF02743.18 EMC86774.1 - 0.16 11.7 0.1 0.22 11.3 0.1 1.2 1 0 0 1 1 1 0 Cache domain UPF0242 PF06785.11 EMC86774.1 - 0.52 10.4 8.1 0.53 10.4 8.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4407 PF14362.6 EMC86774.1 - 0.98 8.7 5.3 0.9 8.8 5.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.19 EMC86774.1 - 1.9 6.3 4.1 1.9 6.3 4.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Hormone_5 PF00184.17 EMC86775.1 - 4.4e-31 107.5 25.8 7.4e-31 106.8 25.8 1.3 1 0 0 1 1 1 1 Neurohypophysial hormones, C-terminal Domain Hormone_4 PF00220.17 EMC86775.1 - 0.0012 18.6 5.0 0.0012 18.6 5.0 2.6 2 0 0 2 2 2 1 Neurohypophysial hormones, N-terminal Domain Hormone_5 PF00184.17 EMC86776.1 - 4.4e-30 104.3 27.8 5.6e-30 104.0 27.8 1.1 1 0 0 1 1 1 1 Neurohypophysial hormones, C-terminal Domain U-box PF04564.15 EMC86777.1 - 2.9e-26 91.5 0.1 6.8e-26 90.2 0.1 1.7 1 0 0 1 1 1 1 U-box domain zf-RING_5 PF14634.6 EMC86777.1 - 0.0001 22.2 6.3 0.0001 22.2 6.3 2.3 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC86777.1 - 0.00095 19.0 5.7 0.0031 17.3 5.7 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EMC86777.1 - 0.0017 18.2 5.0 0.0017 18.2 5.0 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC86777.1 - 0.0021 18.0 6.8 0.0021 18.0 6.8 3.9 4 0 0 4 4 4 1 RING-type zinc-finger DUF3496 PF12001.8 EMC86777.1 - 0.06 13.7 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3496) zf-C3HC4_3 PF13920.6 EMC86777.1 - 0.15 12.0 7.0 0.68 9.8 7.1 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMC86777.1 - 0.22 11.7 11.4 0.17 12.1 7.9 2.7 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 EMC86777.1 - 0.42 10.8 5.3 0.96 9.6 5.3 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 FYVE PF01363.21 EMC86777.1 - 0.94 9.7 5.3 4.4 7.5 5.3 2.3 1 1 0 1 1 1 0 FYVE zinc finger zf-RING_2 PF13639.6 EMC86777.1 - 9.4 6.7 18.9 0.036 14.4 5.6 3.4 4 1 0 4 4 4 0 Ring finger domain FAST_2 PF08368.12 EMC86778.1 - 2e-20 73.4 0.0 5.3e-20 72.0 0.0 1.8 1 0 0 1 1 1 1 FAST kinase-like protein, subdomain 2 FAST_1 PF06743.15 EMC86778.1 - 1.5e-18 66.5 0.7 1.6e-17 63.2 0.1 3.0 4 1 0 4 4 4 1 FAST kinase-like protein, subdomain 1 RAP PF08373.10 EMC86778.1 - 3.3e-13 49.5 1.2 6.1e-13 48.7 1.2 1.5 1 0 0 1 1 1 1 RAP domain Fez1 PF06818.15 EMC86780.1 - 3.2e-77 259.5 46.7 1.8e-74 250.5 24.4 2.4 2 0 0 2 2 2 2 Fez1 ATG16 PF08614.11 EMC86780.1 - 0.00035 20.9 7.5 0.00035 20.9 7.5 3.9 2 1 1 3 3 3 1 Autophagy protein 16 (ATG16) PKcGMP_CC PF16808.5 EMC86780.1 - 0.0018 18.1 2.2 0.0018 18.1 2.2 5.5 4 1 1 5 5 5 1 Coiled-coil N-terminus of cGMP-dependent protein kinase CALCOCO1 PF07888.11 EMC86780.1 - 0.0037 16.2 28.2 0.0037 16.2 28.2 2.2 2 0 0 2 2 2 1 Calcium binding and coiled-coil domain (CALCOCO1) like PyocinActivator PF11112.8 EMC86780.1 - 0.27 11.4 1.8 4.6 7.4 0.4 2.7 2 0 0 2 2 2 0 Pyocin activator protein PrtN ERM PF00769.19 EMC86780.1 - 0.94 9.2 57.4 0.078 12.8 23.4 3.4 2 1 1 3 3 3 0 Ezrin/radixin/moesin family MAD PF05557.13 EMC86780.1 - 2.4 6.4 51.4 0.36 9.2 31.2 2.4 2 0 0 2 2 2 0 Mitotic checkpoint protein FAM184 PF15665.5 EMC86780.1 - 2.5 7.8 51.4 0.29 10.9 19.5 3.3 3 0 0 3 3 3 0 Family with sequence similarity 184, A and B DDRGK PF09756.9 EMC86781.1 - 3.6e-68 228.9 31.6 3.6e-68 228.9 31.6 1.3 2 0 0 2 2 2 1 DDRGK domain PCI PF01399.27 EMC86781.1 - 0.00019 21.9 0.2 0.00037 21.0 0.1 1.6 2 0 0 2 2 1 1 PCI domain FeoC PF09012.10 EMC86781.1 - 0.00031 20.7 0.2 0.56 10.3 0.1 2.5 2 0 0 2 2 2 2 FeoC like transcriptional regulator HTH_DeoR PF08220.12 EMC86781.1 - 0.0089 15.8 0.2 2.7 7.8 0.0 2.4 2 0 0 2 2 2 1 DeoR-like helix-turn-helix domain DUF3347 PF11827.8 EMC86781.1 - 0.041 14.1 7.5 0.075 13.2 7.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) Zip PF02535.22 EMC86781.1 - 0.29 10.3 1.8 0.32 10.2 1.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter PPL5 PF18168.1 EMC86781.1 - 1.4 8.1 7.7 2 7.7 7.7 1.4 1 0 0 1 1 1 0 Prim-pol family 5 Nop53 PF07767.11 EMC86781.1 - 1.8 7.8 42.3 2.8 7.2 42.3 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Presenilin PF01080.17 EMC86781.1 - 2.3 6.9 13.2 2.7 6.7 13.2 1.3 1 0 0 1 1 1 0 Presenilin Spem1 PF15670.5 EMC86781.1 - 3.1 7.3 9.6 1.6 8.2 4.0 2.1 1 1 1 2 2 2 0 Spermatid maturation protein 1 NPR3 PF03666.13 EMC86781.1 - 3.2 6.5 12.3 4.5 5.9 12.3 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 ALMT PF11744.8 EMC86781.1 - 3.2 6.5 9.9 3.8 6.2 9.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Hid1 PF12722.7 EMC86781.1 - 5.4 5.0 9.9 5.7 4.9 9.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein AAA_11 PF13086.6 EMC86781.1 - 6.8 6.4 14.4 9.4 5.9 14.4 1.3 1 0 0 1 1 1 0 AAA domain Ribosomal_S25 PF03297.15 EMC86781.1 - 7.2 6.9 16.8 0.077 13.2 1.9 2.9 1 1 1 2 2 2 0 S25 ribosomal protein AAA_23 PF13476.6 EMC86781.1 - 8.2 6.9 19.6 16 5.9 19.6 1.5 1 0 0 1 1 1 0 AAA domain HCO3_cotransp PF00955.21 EMC86782.1 - 5e-159 530.4 7.6 6.8e-159 529.9 7.6 1.2 1 0 0 1 1 1 1 HCO3- transporter family PTS_EIIA_2 PF00359.22 EMC86782.1 - 6.3e-06 26.1 0.0 0.0023 17.8 0.0 2.9 3 0 0 3 3 3 2 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Band_3_cyto PF07565.13 EMC86782.1 - 3.7e-05 23.7 0.0 7.2e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Band 3 cytoplasmic domain Kelch_1 PF01344.25 EMC86784.1 - 2.5e-26 91.0 4.3 4.6e-05 22.9 0.1 6.7 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 EMC86784.1 - 9.5e-25 86.0 8.5 2.6e-07 30.7 0.0 7.0 6 0 0 6 6 6 5 Kelch motif Kelch_5 PF13854.6 EMC86784.1 - 1.1e-20 73.1 16.0 0.00012 22.0 0.1 6.3 6 0 0 6 6 6 5 Kelch motif Lectin_C PF00059.21 EMC86784.1 - 2.2e-18 67.0 0.4 2.2e-18 67.0 0.4 3.4 3 0 0 3 3 1 1 Lectin C-type domain PSI PF01437.25 EMC86784.1 - 8.2e-17 61.5 116.6 8e-12 45.5 9.9 7.9 7 1 0 7 7 5 5 Plexin repeat Kelch_3 PF13415.6 EMC86784.1 - 9.8e-17 60.8 4.5 0.044 14.1 0.0 7.1 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.6 EMC86784.1 - 1.5e-15 56.9 3.4 0.0019 18.2 0.0 6.8 6 0 0 6 6 6 4 Galactose oxidase, central domain CUB PF00431.20 EMC86784.1 - 6.5e-13 49.0 0.0 2.9e-12 46.9 0.0 2.2 2 0 0 2 2 1 1 CUB domain Kelch_2 PF07646.15 EMC86784.1 - 3.9e-12 45.6 7.6 0.33 11.0 0.0 6.7 6 0 0 6 6 6 4 Kelch motif Laminin_EGF PF00053.24 EMC86784.1 - 0.0018 18.4 16.5 0.0018 18.4 16.5 8.6 6 3 2 8 8 4 2 Laminin EGF domain PSI_integrin PF17205.3 EMC86784.1 - 0.007 16.1 7.5 0.007 16.1 7.5 7.0 6 0 0 6 6 5 2 Integrin plexin domain TMEM100 PF16311.5 EMC86784.1 - 0.018 14.7 0.3 0.044 13.4 0.3 1.6 1 0 0 1 1 1 0 Transmembrane protein 100 GDNF PF02351.16 EMC86785.1 - 9.5e-21 74.6 35.6 1.6e-12 48.2 13.7 3.1 3 0 0 3 3 3 3 GDNF/GAS1 domain NIP_1 PF08995.10 EMC86785.1 - 8.6 6.8 18.0 2.2 8.7 1.1 3.6 3 0 0 3 3 3 0 Necrosis inducing protein-1 Reprolysin PF01421.19 EMC86786.1 - 2.5e-70 236.4 0.0 2.5e-70 236.4 0.0 1.8 2 0 0 2 2 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 EMC86786.1 - 2.1e-32 111.9 11.0 2.1e-32 111.9 11.0 3.3 3 0 0 3 3 1 1 ADAM cysteine-rich Pep_M12B_propep PF01562.19 EMC86786.1 - 1.3e-27 96.7 0.0 2.1e-27 96.1 0.0 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.6 EMC86786.1 - 1.3e-24 87.4 0.5 1.3e-24 87.4 0.5 2.2 3 0 0 3 3 2 1 Metallo-peptidase family M12 Disintegrin PF00200.23 EMC86786.1 - 7.6e-20 71.5 29.6 7.6e-20 71.5 29.6 4.3 2 1 1 3 3 1 1 Disintegrin Reprolysin_3 PF13582.6 EMC86786.1 - 5.4e-17 62.5 0.0 1.1e-16 61.5 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EMC86786.1 - 1.3e-15 57.8 0.1 2.3e-15 57.0 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EMC86786.1 - 4e-11 43.0 0.1 7.7e-11 42.0 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.13 EMC86786.1 - 0.0011 19.2 12.2 0.0011 19.2 12.2 5.3 3 1 0 3 3 2 1 EGF-like domain Peptidase_M43 PF05572.13 EMC86786.1 - 0.012 15.5 0.3 4.5 7.2 0.1 2.7 2 0 0 2 2 2 0 Pregnancy-associated plasma protein-A Peptidase_M54 PF07998.11 EMC86786.1 - 0.063 13.3 0.3 0.16 11.9 0.3 1.6 1 0 0 1 1 1 0 Peptidase family M54 Peptidase_M66 PF10462.9 EMC86786.1 - 0.14 11.0 0.5 0.31 9.9 0.5 1.5 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M10 PF00413.24 EMC86786.1 - 0.16 11.8 0.0 0.26 11.1 0.0 1.3 1 0 0 1 1 1 0 Matrixin ALMS_motif PF15309.6 EMC86787.1 - 3e-31 108.7 14.3 3.3e-31 108.6 14.3 1.0 1 0 0 1 1 1 1 ALMS motif RRM_1 PF00076.22 EMC86791.1 - 2e-34 117.2 0.0 1.1e-16 60.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMC86791.1 - 2.5e-09 36.8 0.0 8e-05 22.2 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 EMC86791.1 - 7.2e-08 32.2 3.0 1.4e-07 31.3 3.0 1.5 1 0 0 1 1 1 1 Zinc knuckle RRM_7 PF16367.5 EMC86791.1 - 4.7e-06 26.6 0.0 0.01 15.9 0.0 2.8 2 2 0 2 2 2 2 RNA recognition motif Calcipressin PF04847.12 EMC86791.1 - 0.00029 20.7 0.1 0.7 9.6 0.0 2.1 1 1 1 2 2 2 2 Calcipressin RRM_occluded PF16842.5 EMC86791.1 - 0.00067 19.5 0.0 0.071 13.0 0.0 2.4 1 1 0 2 2 2 1 Occluded RNA-recognition motif zf-CCHC_3 PF13917.6 EMC86791.1 - 0.0012 18.8 0.5 0.0024 17.8 0.5 1.4 1 0 0 1 1 1 1 Zinc knuckle DbpA PF03880.15 EMC86791.1 - 0.0015 18.5 0.1 0.87 9.6 0.0 2.3 2 0 0 2 2 2 2 DbpA RNA binding domain RNA_bind PF08675.11 EMC86791.1 - 0.0032 17.5 0.0 0.61 10.2 0.0 2.4 2 0 0 2 2 2 1 RNA binding domain Limkain-b1 PF11608.8 EMC86791.1 - 0.0055 16.8 0.1 1.1 9.3 0.0 2.3 2 0 0 2 2 2 1 Limkain b1 zf-CCHC_2 PF13696.6 EMC86791.1 - 0.0084 15.9 3.0 0.014 15.2 3.0 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 EMC86791.1 - 0.04 13.6 3.1 0.076 12.7 3.1 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger OxoDH_E1alpha_N PF12573.8 EMC86791.1 - 0.068 12.9 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal RSD-2 PF07547.13 EMC86791.1 - 0.1 13.1 0.8 3.2 8.3 0.0 2.4 2 0 0 2 2 2 0 RSD-2 N-terminal domain Lectin_C PF00059.21 EMC86793.1 - 0.00013 22.7 0.1 0.00024 21.8 0.0 1.5 1 1 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 EMC86793.1 - 0.14 11.8 0.2 0.15 11.7 0.2 1.1 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C PF00059.21 EMC86795.1 - 4.3e-17 62.8 0.2 8.6e-17 61.8 0.2 1.5 1 0 0 1 1 1 1 Lectin C-type domain PMP22_Claudin PF00822.20 EMC86796.1 - 5.6e-44 149.9 19.0 6.4e-44 149.8 19.0 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC86796.1 - 2.8e-06 27.2 12.3 2.8e-06 27.2 12.3 2.2 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction Amastin PF07344.11 EMC86796.1 - 7.8e-05 22.6 17.3 0.00014 21.7 17.3 1.5 1 1 0 1 1 1 1 Amastin surface glycoprotein DUF998 PF06197.13 EMC86796.1 - 0.00036 20.2 1.6 0.00036 20.2 1.6 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF998) DUF1422 PF07226.11 EMC86796.1 - 0.0016 18.5 3.7 0.0016 18.5 3.7 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1422) DUF4064 PF13273.6 EMC86796.1 - 0.0042 17.4 20.5 0.017 15.3 10.8 2.4 2 1 0 2 2 2 2 Protein of unknown function (DUF4064) L_HMGIC_fpl PF10242.9 EMC86796.1 - 0.068 13.4 16.1 0.12 12.5 16.0 1.5 1 1 0 1 1 1 0 Lipoma HMGIC fusion partner-like protein DUF2615 PF11027.8 EMC86796.1 - 0.092 12.9 0.2 0.092 12.9 0.2 2.3 2 1 2 4 4 4 0 Protein of unknown function (DUF2615) Claudin_3 PF06653.11 EMC86796.1 - 0.27 11.1 21.6 0.73 9.8 21.6 1.7 1 1 0 1 1 1 0 Tight junction protein, Claudin-like DUF2569 PF10754.9 EMC86796.1 - 1.5 9.3 18.1 0.075 13.5 9.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2569) MARVEL PF01284.23 EMC86796.1 - 3.9 7.5 22.4 13 5.8 1.8 2.8 1 1 0 2 2 2 0 Membrane-associating domain PalH PF08733.10 EMC86796.1 - 8.1 5.3 16.1 0.21 10.6 6.3 2.0 2 0 0 2 2 2 0 PalH/RIM21 GSG-1 PF07803.11 EMC86797.1 - 7.6e-51 170.9 0.0 1.5e-50 170.0 0.0 1.4 1 0 0 1 1 1 1 GSG1-like protein PMP22_Claudin PF00822.20 EMC86797.1 - 1.9e-08 34.4 3.1 3.5e-08 33.5 3.1 1.5 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_3 PF06653.11 EMC86797.1 - 0.00058 19.8 1.3 0.037 14.0 0.7 2.2 2 0 0 2 2 2 1 Tight junction protein, Claudin-like Claudin_2 PF13903.6 EMC86797.1 - 0.00068 19.4 7.9 0.0023 17.7 7.9 1.9 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction L_HMGIC_fpl PF10242.9 EMC86797.1 - 0.0032 17.7 4.4 0.022 15.0 4.4 2.1 1 1 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein Clc-like PF07062.12 EMC86797.1 - 0.045 13.2 7.1 1.1 8.7 0.0 2.8 3 0 0 3 3 3 0 Clc-like DUF4235 PF14019.6 EMC86797.1 - 0.12 12.5 0.2 0.22 11.6 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4235) PQQ_2 PF13360.6 EMC86798.1 - 5.7e-07 29.4 0.1 0.0032 17.1 0.0 2.4 2 0 0 2 2 2 2 PQQ-like domain VCBS PF13517.6 EMC86798.1 - 2.8e-06 27.8 0.0 0.11 13.1 0.0 3.2 3 0 0 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 EMC86798.1 - 3e-05 24.0 2.5 0.042 14.0 0.3 2.8 2 0 0 2 2 2 2 FG-GAP repeat DUF1409 PF07197.12 EMC86799.1 - 0.0085 16.0 0.1 0.017 15.0 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1409) I_LWEQ PF01608.17 EMC86799.1 - 0.067 13.4 0.1 0.1 12.8 0.1 1.2 1 0 0 1 1 1 0 I/LWEQ domain HxlR PF01638.17 EMC86799.1 - 0.14 12.1 2.2 0.2 11.5 0.6 2.0 2 0 0 2 2 2 0 HxlR-like helix-turn-helix SOUL PF04832.12 EMC86800.1 - 5.2e-38 130.9 0.0 5.8e-38 130.7 0.0 1.0 1 0 0 1 1 1 1 SOUL heme-binding protein 7tm_3 PF00003.22 EMC86801.1 - 4.8e-26 91.9 30.8 6.6e-26 91.5 30.8 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Tetraspanin PF00335.20 EMC86801.1 - 0.0025 17.6 3.1 0.0025 17.6 3.1 2.6 2 0 0 2 2 2 1 Tetraspanin family Glucos_trans_II PF14264.6 EMC86801.1 - 0.055 12.8 26.7 0.11 11.9 5.3 2.3 1 1 1 2 2 2 0 Glucosyl transferase GtrII DUF1345 PF07077.11 EMC86801.1 - 0.65 9.7 13.6 2.4 7.8 2.2 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1345) ABC2_membrane_5 PF13346.6 EMC86801.1 - 0.71 9.4 32.9 0.11 12.0 15.0 2.4 1 1 1 2 2 2 0 ABC-2 family transporter protein 7TMR-DISM_7TM PF07695.11 EMC86801.1 - 4.5 7.1 34.2 23 4.8 33.9 2.1 1 1 0 1 1 1 0 7TM diverse intracellular signalling DUF3169 PF11368.8 EMC86801.1 - 7.5 6.0 20.7 0.49 9.9 8.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3169) DEAD PF00270.29 EMC86802.1 - 3.3e-48 163.8 0.2 5.2e-48 163.1 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC86802.1 - 3.8e-32 110.9 0.8 3e-31 108.0 0.0 2.8 4 0 0 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC86802.1 - 3.8e-06 27.0 0.0 7.4e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 EMC86802.1 - 0.014 15.1 0.0 0.067 12.8 0.0 2.0 2 1 0 2 2 2 0 SWI2/SNF2 ATPase ApoL PF05461.11 EMC86803.1 - 1.5e-14 54.1 2.0 1.5e-14 54.1 2.0 1.5 2 0 0 2 2 2 1 Apolipoprotein L SseC PF04888.12 EMC86803.1 - 0.00064 19.4 0.9 1.1 8.8 0.0 2.0 1 1 1 2 2 2 2 Secretion system effector C (SseC) like family Snapin_Pallidin PF14712.6 EMC86803.1 - 0.091 13.2 1.7 3.2 8.2 0.1 2.5 2 0 0 2 2 2 0 Snapin/Pallidin Prefoldin PF02996.17 EMC86803.1 - 0.26 11.2 1.7 9.9 6.1 0.0 2.6 3 0 0 3 3 3 0 Prefoldin subunit Takusan PF04822.13 EMC86803.1 - 1.8 8.5 6.0 0.5 10.3 0.3 2.4 3 0 0 3 3 3 0 Takusan Histone_H2A_C PF16211.5 EMC86804.1 - 3.9e-20 71.3 1.1 6.3e-20 70.6 1.1 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EMC86804.1 - 1.9e-16 60.6 0.0 2.3e-16 60.3 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC86804.1 - 2.8e-05 24.3 0.0 3.9e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EMC86805.1 - 1.3e-25 90.3 0.3 1.5e-25 90.0 0.3 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC86805.1 - 9.1e-07 29.1 0.7 1.8e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EMC86805.1 - 0.003 18.0 0.0 0.006 17.1 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 EMC86805.1 - 0.0043 17.1 0.3 0.0049 16.9 0.3 1.1 1 0 0 1 1 1 1 YscO-like protein Histone PF00125.24 EMC86806.1 - 6.6e-26 91.2 0.6 7.8e-26 91.0 0.6 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC86806.1 - 1e-06 28.9 1.3 1.7e-06 28.2 0.0 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EMC86806.1 - 0.0031 18.0 0.0 0.0055 17.2 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 EMC86806.1 - 0.0041 17.2 0.4 0.0049 16.9 0.4 1.2 1 0 0 1 1 1 1 YscO-like protein Histone_H2A_C PF16211.5 EMC86807.1 - 4.1e-20 71.2 1.1 7.5e-20 70.4 1.1 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EMC86807.1 - 2.5e-17 63.5 0.0 3.2e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC86807.1 - 3.5e-05 24.0 0.0 4.9e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Ribosomal_L27A PF00828.19 EMC86807.1 - 0.036 14.8 0.1 0.043 14.5 0.1 1.2 1 0 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Histone PF00125.24 EMC86808.1 - 1.1e-25 90.5 0.5 1.3e-25 90.3 0.5 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC86808.1 - 1e-06 28.9 1.5 1.5e-06 28.3 0.0 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EMC86808.1 - 0.0028 18.1 0.0 0.005 17.3 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 EMC86808.1 - 0.0046 17.0 0.6 0.0054 16.8 0.6 1.2 1 0 0 1 1 1 1 YscO-like protein Histone_H2A_C PF16211.5 EMC86809.1 - 4.1e-20 71.2 1.1 7.5e-20 70.4 1.1 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EMC86809.1 - 2.5e-17 63.5 0.0 3.2e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC86809.1 - 3.5e-05 24.0 0.0 4.9e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Ribosomal_L27A PF00828.19 EMC86809.1 - 0.036 14.8 0.1 0.043 14.5 0.1 1.2 1 0 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Histone PF00125.24 EMC86810.1 - 6.9e-26 91.2 0.6 8e-26 90.9 0.6 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC86810.1 - 9.9e-07 29.0 0.9 1.8e-06 28.1 0.0 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EMC86810.1 - 0.0031 18.0 0.0 0.006 17.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 EMC86810.1 - 0.0033 17.5 0.3 0.004 17.2 0.3 1.2 1 0 0 1 1 1 1 YscO-like protein Histone_H2A_C PF16211.5 EMC86811.1 - 4.1e-20 71.2 1.1 7.1e-20 70.4 1.1 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EMC86811.1 - 2.7e-17 63.4 0.0 3.4e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC86811.1 - 3.3e-05 24.1 0.0 4.6e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Ribosomal_L27A PF00828.19 EMC86811.1 - 0.047 14.4 0.1 0.056 14.1 0.1 1.2 1 0 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Linker_histone PF00538.19 EMC86812.1 - 7e-22 77.6 0.7 7e-22 77.6 0.7 1.9 2 0 0 2 2 2 1 linker histone H1 and H5 family CENP-T_C PF15511.6 EMC86813.1 - 2e-08 34.3 0.1 2.5e-08 34.0 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 EMC86813.1 - 2.8e-05 24.2 0.2 3.9e-05 23.7 0.2 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 EMC86813.1 - 5.3e-05 23.5 0.1 6.9e-05 23.1 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 EMC86813.1 - 0.00019 21.8 0.3 0.00022 21.6 0.3 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC86813.1 - 0.00031 21.0 0.1 0.00049 20.3 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EMC86813.1 - 0.0066 16.5 0.0 0.0076 16.3 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EMC86813.1 - 0.027 14.5 0.1 0.041 13.9 0.1 1.2 1 0 0 1 1 1 0 Bromodomain associated Histone_H2A_C PF16211.5 EMC86814.1 - 3.9e-20 71.3 1.1 6.8e-20 70.5 1.1 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EMC86814.1 - 3.5e-17 63.0 0.0 4.2e-17 62.7 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC86814.1 - 3.1e-05 24.2 0.0 4.3e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EMC86815.1 - 6.8e-54 181.7 2.3 7.6e-54 181.6 2.3 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EMC86815.1 - 8.4e-05 22.6 0.3 0.00015 21.8 0.0 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 EMC86815.1 - 0.00019 22.0 1.2 0.00023 21.8 1.2 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-S PF15630.6 EMC86815.1 - 0.00042 20.6 0.0 0.00064 20.0 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EMC86815.1 - 0.011 16.0 0.1 0.022 15.0 0.1 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EMC86815.1 - 0.11 12.6 0.1 0.21 11.7 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Histone_H2A_C PF16211.5 EMC86816.1 - 4.1e-20 71.2 1.1 7.1e-20 70.4 1.1 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EMC86816.1 - 2.6e-17 63.4 0.0 3.4e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC86816.1 - 3.3e-05 24.1 0.0 4.6e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Ribosomal_L27A PF00828.19 EMC86816.1 - 0.048 14.3 0.1 0.058 14.1 0.1 1.2 1 0 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A CENP-T_C PF15511.6 EMC86817.1 - 1.8e-08 34.5 0.1 2.2e-08 34.2 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 EMC86817.1 - 2.5e-05 24.4 0.2 3.5e-05 23.9 0.2 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 EMC86817.1 - 4.6e-05 23.7 0.1 6.1e-05 23.3 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 EMC86817.1 - 0.00017 21.9 0.3 0.00019 21.8 0.3 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC86817.1 - 0.00028 21.1 0.1 0.00046 20.4 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EMC86817.1 - 0.0059 16.7 0.0 0.0067 16.5 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EMC86817.1 - 0.024 14.6 0.1 0.037 14.0 0.1 1.2 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 EMC86817.1 - 0.21 11.4 0.1 0.25 11.1 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) 7tm_1 PF00001.21 EMC86818.1 - 9e-63 212.0 22.1 1.2e-62 211.7 22.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC86818.1 - 1.3e-10 41.1 22.4 1.8e-10 40.6 22.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 EMC86818.1 - 1.5e-07 31.1 17.9 1.5e-07 31.1 17.9 1.8 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 EMC86818.1 - 3.7e-07 30.1 16.3 3.7e-07 30.1 16.3 1.7 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx EVC2_like PF12297.8 EMC86818.1 - 0.063 12.0 1.0 0.79 8.3 0.0 2.1 2 0 0 2 2 2 0 Ellis van Creveld protein 2 like protein Saf_2TM PF18303.1 EMC86818.1 - 0.23 11.1 4.4 0.22 11.1 0.9 2.4 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain 7tm_1 PF00001.21 EMC86819.1 - 9.4e-52 175.9 23.3 1.1e-51 175.7 23.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC86819.1 - 1.3e-11 44.3 21.0 1.9e-11 43.8 21.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 EMC86819.1 - 1.3e-06 28.0 13.5 1.3e-06 28.0 13.5 1.9 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srw PF10324.9 EMC86819.1 - 3.6e-06 26.5 24.0 1.2e-05 24.7 24.0 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srx PF10328.9 EMC86819.1 - 1.9e-05 24.4 18.6 1.9e-05 24.4 18.6 1.9 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx SK_channel PF03530.14 EMC86819.1 - 0.03 14.3 6.5 0.14 12.1 6.5 2.2 1 1 0 1 1 1 0 Calcium-activated SK potassium channel PSP1 PF04468.12 EMC86820.1 - 0.029 14.6 0.9 0.052 13.8 0.1 1.8 2 0 0 2 2 2 0 PSP1 C-terminal conserved region ATG11 PF10377.9 EMC86821.1 - 2.1e-25 89.2 0.0 2.1e-25 89.2 0.0 5.8 5 2 1 7 7 7 1 Autophagy-related protein 11 TBK1_ULD PF18396.1 EMC86821.1 - 0.00047 20.0 0.4 0.004 17.1 0.0 2.6 2 0 0 2 2 2 1 TANK binding kinase 1 ubiquitin-like domain MYT1 PF08474.11 EMC86822.1 - 1.5e-85 287.0 6.6 1.5e-85 287.0 6.6 2.3 2 1 0 2 2 1 1 Myelin transcription factor 1 zf-C2HC PF01530.18 EMC86822.1 - 1.8e-82 271.1 80.1 1.1e-15 57.5 7.4 6.5 6 0 0 6 6 6 6 Zinc finger, C2HC type YabA PF06156.13 EMC86822.1 - 0.062 13.9 7.9 0.072 13.7 3.6 2.9 2 0 0 2 2 2 0 Initiation control protein YabA DUF1664 PF07889.12 EMC86822.1 - 0.071 13.1 2.4 0.13 12.3 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FapA PF03961.13 EMC86822.1 - 0.077 11.6 5.1 0.25 9.9 4.5 2.0 2 0 0 2 2 2 0 Flagellar Assembly Protein A Tho2 PF11262.8 EMC86822.1 - 0.2 10.8 2.6 0.41 9.8 2.6 1.5 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 zf-RAG1 PF10426.9 EMC86822.1 - 0.45 10.7 8.2 10 6.4 0.0 5.4 5 0 0 5 5 5 0 Recombination-activating protein 1 zinc-finger domain DUF16 PF01519.16 EMC86822.1 - 0.77 10.3 4.9 0.91 10.0 2.0 2.4 2 0 0 2 2 2 0 Protein of unknown function DUF16 HAUS-augmin3 PF14932.6 EMC86822.1 - 0.82 9.2 11.2 0.078 12.5 6.0 1.9 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 SlyX PF04102.12 EMC86822.1 - 0.85 10.3 7.5 0.31 11.7 3.9 2.2 2 0 0 2 2 2 0 SlyX Bcr-Abl_Oligo PF09036.10 EMC86822.1 - 1.4 9.0 4.0 0.8 9.7 0.1 2.7 4 0 0 4 4 3 0 Bcr-Abl oncoprotein oligomerisation domain Chisel PF15355.6 EMC86822.1 - 6.5 7.1 6.2 3.1 8.1 1.7 2.9 3 0 0 3 3 3 0 Stretch-responsive small skeletal muscle X protein, Chisel DivIC PF04977.15 EMC86822.1 - 7.8 6.3 7.3 17 5.3 5.8 2.2 1 1 1 2 2 2 0 Septum formation initiator PCMT PF01135.19 EMC86823.1 - 3e-28 99.0 0.0 4.1e-28 98.6 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) SOCS_box PF07525.16 EMC86823.1 - 1e-06 29.0 1.2 0.011 16.1 0.8 2.6 2 0 0 2 2 2 2 SOCS box DOT1 PF08123.13 EMC86823.1 - 0.00014 21.4 0.0 0.00023 20.7 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_31 PF13847.6 EMC86823.1 - 0.0024 17.7 0.0 0.004 17.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.10 EMC86823.1 - 0.0084 15.8 0.0 0.024 14.3 0.0 1.6 2 0 0 2 2 2 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_25 PF13649.6 EMC86823.1 - 0.044 14.5 0.0 0.11 13.2 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Septin PF00735.18 EMC86824.1 - 2.4e-131 437.1 0.5 3.4e-131 436.7 0.5 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EMC86824.1 - 1.8e-08 34.5 0.0 4.4e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC86824.1 - 5.1e-08 33.0 0.2 4.8e-06 26.6 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EMC86824.1 - 3.9e-05 23.3 1.0 0.053 13.0 0.0 2.6 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.16 EMC86824.1 - 0.0013 18.1 0.0 0.0025 17.2 0.0 1.5 1 0 0 1 1 1 1 AIG1 family AAA_23 PF13476.6 EMC86824.1 - 0.0037 17.8 0.4 0.02 15.4 0.4 2.0 1 1 0 1 1 1 1 AAA domain Ras PF00071.22 EMC86824.1 - 0.014 15.0 0.1 0.031 13.9 0.1 1.6 1 0 0 1 1 1 0 Ras family Roc PF08477.13 EMC86824.1 - 0.015 15.5 0.1 0.035 14.3 0.1 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 EMC86824.1 - 0.016 15.6 0.0 0.044 14.2 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain Dynamin_N PF00350.23 EMC86824.1 - 0.028 14.5 4.5 0.65 10.0 0.1 3.0 2 1 1 3 3 3 0 Dynamin family AAA_22 PF13401.6 EMC86824.1 - 0.037 14.3 0.3 0.15 12.3 0.0 2.2 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EMC86824.1 - 0.054 13.3 0.1 0.13 12.0 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EMC86824.1 - 0.087 13.3 1.2 0.14 12.6 0.2 2.0 2 1 0 2 2 2 0 ABC transporter LRR_8 PF13855.6 EMC86825.1 - 6.8e-06 25.8 0.0 1.4e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Leucine rich repeat LRRNT PF01462.18 EMC86825.1 - 2.5e-05 23.8 2.0 2.5e-05 23.8 2.0 3.0 3 1 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_4 PF12799.7 EMC86825.1 - 4.4e-05 23.8 0.1 8.8e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) LRRCT PF01463.24 EMC86825.1 - 0.027 15.0 0.0 0.065 13.8 0.0 1.7 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain TssO PF17561.2 EMC86825.1 - 0.21 11.7 0.7 0.33 11.0 0.7 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssO T-box PF00907.22 EMC86826.1 - 3e-63 213.4 0.1 3.5e-63 213.2 0.1 1.0 1 0 0 1 1 1 1 T-box WD40 PF00400.32 EMC86827.1 - 1.4e-21 76.4 4.4 0.0042 17.9 0.1 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC86827.1 - 2.4e-09 37.3 0.1 0.07 13.4 0.0 4.4 5 0 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 EMC86827.1 - 0.0041 16.1 0.3 1.7 7.5 0.0 3.4 2 2 1 3 3 3 2 Partner and localizer of BRCA2 WD40 domain Pyr_redox_2 PF07992.14 EMC86828.1 - 6.1e-50 170.1 0.0 9.5e-50 169.5 0.0 1.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EMC86828.1 - 1.4e-30 105.8 0.0 2.4e-30 105.0 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EMC86828.1 - 1.3e-12 48.1 0.2 3.4e-08 33.9 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMC86828.1 - 4e-08 32.8 2.8 7.4e-07 28.6 2.2 2.6 2 1 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.6 EMC86828.1 - 4e-07 29.6 1.0 0.028 13.7 0.0 2.6 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMC86828.1 - 1.9e-05 23.6 1.1 0.00048 18.9 0.2 2.4 2 1 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 EMC86828.1 - 7.2e-05 22.0 1.4 0.0005 19.3 1.5 1.9 1 1 0 1 1 1 1 Glucose inhibited division protein A DAO PF01266.24 EMC86828.1 - 0.00018 21.2 2.6 0.0042 16.7 0.8 2.6 2 1 1 3 3 3 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 EMC86828.1 - 0.00021 20.6 0.2 0.074 12.2 0.0 2.5 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EMC86828.1 - 0.00025 20.4 0.0 0.00045 19.5 0.0 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 EMC86828.1 - 0.0024 18.1 0.3 0.0067 16.6 0.3 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EMC86828.1 - 0.0026 17.2 2.7 0.003 17.0 1.8 1.8 2 1 0 2 2 2 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EMC86828.1 - 0.0058 16.0 0.0 0.01 15.2 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 EMC86828.1 - 0.65 9.0 1.9 0.44 9.5 0.1 1.6 2 0 0 2 2 2 0 Lycopene cyclase protein Methyltransf_3 PF01596.17 EMC86829.1 - 2.1e-22 79.4 0.0 2.8e-22 78.9 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 EMC86829.1 - 3.2e-13 50.6 0.0 4.9e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.12 EMC86829.1 - 0.00037 20.3 0.0 0.00061 19.5 0.0 1.3 1 0 0 1 1 1 1 Cephalosporin hydroxylase PCMT PF01135.19 EMC86829.1 - 0.0013 18.6 0.0 0.002 17.9 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EMC86829.1 - 0.0019 18.0 0.0 0.0041 16.9 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC86829.1 - 0.13 13.0 0.0 0.2 12.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.15 EMC86829.1 - 0.13 11.9 0.0 0.77 9.4 0.0 2.0 2 0 0 2 2 2 0 Conserved hypothetical protein 95 GCD14 PF08704.10 EMC86829.1 - 0.14 11.8 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Arm PF00514.23 EMC86830.1 - 1.2e-38 130.0 0.7 4.6e-08 32.8 0.0 7.5 7 0 0 7 7 7 6 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EMC86830.1 - 1.1e-10 41.8 3.1 0.00032 21.0 0.0 4.1 4 0 0 4 4 4 2 HEAT repeats HEAT_EZ PF13513.6 EMC86830.1 - 4.7e-10 39.8 1.1 0.29 11.7 0.1 5.4 5 0 0 5 5 5 3 HEAT-like repeat HEAT PF02985.22 EMC86830.1 - 3.5e-09 36.1 0.4 0.81 10.1 0.0 5.2 5 0 0 5 5 5 3 HEAT repeat Arm_2 PF04826.13 EMC86830.1 - 8.7e-06 25.4 0.2 0.026 14.0 0.0 3.7 2 2 2 4 4 4 2 Armadillo-like Atx10homo_assoc PF09759.9 EMC86830.1 - 3.6e-05 23.7 2.0 0.009 16.0 0.0 3.7 3 0 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain Cnd1 PF12717.7 EMC86830.1 - 0.0024 18.0 0.1 0.45 10.5 0.1 2.6 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 UNC45-central PF11701.8 EMC86830.1 - 0.13 12.2 1.1 6.7 6.7 0.1 3.1 2 1 0 3 3 3 0 Myosin-binding striated muscle assembly central TANGO2 PF05742.12 EMC86831.1 - 1.8e-06 28.2 0.0 1.8e-06 28.2 0.0 1.0 1 0 0 1 1 1 1 Transport and Golgi organisation 2 dsrm PF00035.26 EMC86832.1 - 2.1e-20 73.2 4.1 2.5e-12 47.3 0.0 4.1 3 1 0 3 3 3 2 Double-stranded RNA binding motif Ran_BP1 PF00638.18 EMC86833.1 - 2.8e-54 182.6 0.4 2.8e-54 182.6 0.4 1.9 2 0 0 2 2 2 1 RanBP1 domain PKI PF02827.16 EMC86833.1 - 0.066 13.4 5.7 0.16 12.2 5.7 1.8 1 0 0 1 1 1 0 cAMP-dependent protein kinase inhibitor DUF883 PF05957.13 EMC86833.1 - 0.11 13.1 2.9 13 6.5 1.7 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) PIG-S PF10510.9 EMC86833.1 - 0.17 10.7 1.5 0.2 10.5 1.5 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein His_Phos_1 PF00300.22 EMC86834.1 - 1.3e-22 80.4 0.4 8.1e-21 74.6 0.4 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) CUB PF00431.20 EMC86835.1 - 3.7e-20 72.3 0.0 8e-20 71.2 0.0 1.6 1 0 0 1 1 1 1 CUB domain Kringle PF00051.18 EMC86835.1 - 3.4e-19 68.9 7.4 7.7e-19 67.8 7.4 1.6 1 0 0 1 1 1 1 Kringle domain WSC PF01822.19 EMC86835.1 - 1.4e-18 66.8 9.3 3.9e-18 65.4 9.3 1.8 1 0 0 1 1 1 1 WSC domain zf-RING_2 PF13639.6 EMC86836.1 - 1.8e-06 28.2 7.9 1.8e-06 28.2 7.9 3.2 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC86836.1 - 9.6e-06 25.3 7.8 9.6e-06 25.3 7.8 3.1 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EMC86836.1 - 2.2e-05 24.1 1.1 0.00035 20.2 0.6 3.1 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.7 EMC86836.1 - 0.00017 21.8 9.2 0.00017 21.8 9.2 2.7 3 0 0 3 3 3 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EMC86836.1 - 0.00078 19.3 5.4 0.00078 19.3 5.4 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC86836.1 - 0.0062 16.4 8.8 0.04 13.8 8.8 2.5 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 ZNRF_3_ecto PF18212.1 EMC86837.1 - 3e-42 142.9 0.0 3.4e-42 142.7 0.0 1.0 1 0 0 1 1 1 1 ZNRF-3 Ectodomain PA PF02225.22 EMC86837.1 - 0.0048 16.9 0.0 0.0058 16.6 0.0 1.2 1 0 0 1 1 1 1 PA domain CCDC117 PF15810.5 EMC86839.1 - 1e-59 200.9 0.4 1.3e-59 200.6 0.4 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 117 HSCB_C PF07743.13 EMC86840.1 - 1.5e-16 60.7 8.0 1.5e-16 60.7 8.0 1.4 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain TRM PF02005.16 EMC86840.1 - 0.17 11.0 1.4 0.21 10.7 1.4 1.1 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Interferon PF00143.19 EMC86840.1 - 2.1 8.5 5.9 1.1 9.4 3.3 1.8 1 1 1 2 2 2 0 Interferon alpha/beta domain Pkinase PF00069.25 EMC86841.1 - 2.1e-74 250.2 0.0 2.8e-74 249.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC86841.1 - 4e-32 111.5 0.0 5.5e-32 111.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EMC86841.1 - 3.1e-12 46.6 0.0 6.5e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.6 EMC86841.1 - 4.6e-08 32.7 0.0 6.8e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMC86841.1 - 0.0089 14.8 0.4 0.017 13.9 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EMC86841.1 - 0.012 14.9 0.0 0.02 14.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EMC86841.1 - 0.038 13.6 0.1 0.062 12.9 0.1 1.3 1 0 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.9 EMC86841.1 - 0.067 12.7 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Haspin_kinase PF12330.8 EMC86841.1 - 0.089 11.7 0.1 0.19 10.7 0.1 1.5 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 EMC86841.1 - 0.22 11.4 0.0 0.35 10.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family IP_trans PF02121.18 EMC86843.1 - 3.7e-116 387.0 2.3 4.2e-116 386.8 2.3 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein Crystall PF00030.19 EMC86845.1 - 7.4e-55 183.1 4.2 9.5e-28 96.2 0.9 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin Crystall PF00030.19 EMC86846.1 - 8.2e-60 199.0 3.3 3.2e-29 101.0 0.4 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.13 EMC86846.1 - 7.7e-08 32.2 0.0 0.016 15.2 0.0 2.4 2 0 0 2 2 2 2 Peptidase inhibitor family I36 IL4_i_Ig PF18258.1 EMC86846.1 - 0.0015 18.7 1.1 21 5.4 0.0 4.2 2 2 2 4 4 4 2 Interleukin-4 inducing immunoglobulin-binding domain GCFC PF07842.12 EMC86848.1 - 3.4e-98 328.7 17.3 1.1e-97 327.0 14.8 2.2 2 0 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein TIP_N PF12457.8 EMC86848.1 - 9.7e-28 96.6 8.1 9.7e-28 96.6 8.1 2.1 2 0 0 2 2 2 1 Tuftelin interacting protein N terminal G-patch PF01585.23 EMC86848.1 - 1.4e-16 60.1 4.3 2.6e-16 59.2 4.3 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EMC86848.1 - 0.00018 21.6 1.1 0.00053 20.0 1.1 1.9 1 0 0 1 1 1 1 G-patch domain SRR1 PF07985.12 EMC86849.1 - 0.019 15.0 0.0 0.029 14.4 0.0 1.3 1 0 0 1 1 1 0 SRR1 Asp_Arg_Hydrox PF05118.15 EMC86851.1 - 1.1e-50 171.5 0.0 2.2e-50 170.6 0.0 1.5 2 0 0 2 2 2 1 Aspartyl/Asparaginyl beta-hydroxylase UQ_con PF00179.26 EMC86851.1 - 0.18 11.5 0.0 0.39 10.3 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme Sushi PF00084.20 EMC86852.1 - 7.8e-45 151.3 24.0 1.5e-11 44.7 0.9 5.5 5 0 0 5 5 5 5 Sushi repeat (SCR repeat) CUB PF00431.20 EMC86852.1 - 2.3e-39 134.2 0.0 5.2e-19 68.6 0.0 3.6 3 0 0 3 3 3 3 CUB domain CUB_2 PF02408.20 EMC86852.1 - 1.7e-05 24.6 0.0 0.55 10.0 0.0 3.4 3 0 0 3 3 3 3 CUB-like domain Amnionless PF14828.6 EMC86852.1 - 0.032 13.1 0.0 0.052 12.4 0.0 1.2 1 0 0 1 1 1 0 Amnionless Pkinase PF00069.25 EMC86853.1 - 6.1e-74 248.7 0.0 9.9e-73 244.7 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC86853.1 - 6.2e-29 101.1 0.0 9.9e-29 100.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.19 EMC86853.1 - 1.1e-17 64.4 2.7 1.9e-17 63.6 2.7 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain PH PF00169.29 EMC86853.1 - 7.7e-11 42.4 0.3 1.5e-10 41.5 0.3 1.6 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 EMC86853.1 - 0.0017 17.7 0.0 0.0026 17.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMC86853.1 - 0.0071 15.2 0.0 0.015 14.1 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase HTH_WhiA PF02650.14 EMC86853.1 - 0.088 13.1 0.2 0.28 11.6 0.2 1.8 1 0 0 1 1 1 0 WhiA C-terminal HTH domain Crystall PF00030.19 EMC86854.1 - 8.7e-43 144.4 3.6 1.5e-30 105.2 0.2 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.13 EMC86854.1 - 0.022 14.7 0.2 0.12 12.3 0.0 2.0 2 0 0 2 2 2 0 Peptidase inhibitor family I36 Crystall_3 PF08964.10 EMC86854.1 - 0.088 13.0 1.0 1.1 9.5 0.3 2.3 2 1 0 2 2 2 0 Beta/Gamma crystallin Crystall PF00030.19 EMC86855.1 - 8.1e-57 189.4 0.3 1.4e-27 95.7 0.1 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.13 EMC86855.1 - 0.00024 21.0 0.0 0.011 15.6 0.0 2.5 2 1 0 2 2 2 1 Peptidase inhibitor family I36 IL4_i_Ig PF18258.1 EMC86855.1 - 0.0066 16.6 0.7 71 3.7 0.0 4.1 1 1 3 4 4 4 0 Interleukin-4 inducing immunoglobulin-binding domain Tankyrase_bdg_C PF15327.6 EMC86856.1 - 1.5e-60 204.5 15.5 1.5e-60 204.5 15.5 6.2 7 1 2 9 9 9 1 Tankyrase binding protein C terminal domain DUF4837 PF16125.5 EMC86857.1 - 0.09 11.8 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4837) DUF5541 PF17695.1 EMC86857.1 - 0.13 12.7 0.0 0.16 12.4 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5541) SNF PF00209.18 EMC86858.1 - 5.8e-142 474.0 19.9 6.5e-142 473.9 19.9 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family GPCR_chapero_1 PF11904.8 EMC86860.1 - 1.8e-97 326.5 0.0 2.9e-97 325.8 0.0 1.3 1 0 0 1 1 1 1 GPCR-chaperone Ank_4 PF13637.6 EMC86860.1 - 1.7e-11 44.4 0.0 4.5e-11 43.0 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC86860.1 - 9.8e-11 42.1 0.0 2.4e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC86860.1 - 7.6e-10 38.2 0.0 0.0022 18.3 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EMC86860.1 - 5.4e-09 36.1 0.0 3.2e-06 27.3 0.0 3.5 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EMC86860.1 - 1.9e-07 31.2 0.0 0.011 16.1 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat UIM PF02809.20 EMC86860.1 - 0.17 11.9 20.1 0.28 11.2 1.6 4.2 4 0 0 4 4 4 0 Ubiquitin interaction motif GIT1_C PF12205.8 EMC86861.1 - 3.3e-46 156.2 4.4 3.3e-46 156.2 4.4 2.7 2 0 0 2 2 2 1 G protein-coupled receptor kinase-interacting protein 1 C term GIT_CC PF16559.5 EMC86861.1 - 2.2e-27 94.7 8.3 3.4e-27 94.1 7.0 2.1 2 0 0 2 2 1 1 GIT coiled-coil Rho guanine nucleotide exchange factor GIT_SHD PF08518.11 EMC86861.1 - 2.3e-27 94.3 1.6 7.9e-14 51.0 0.1 2.8 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT ArfGap PF01412.18 EMC86861.1 - 3.7e-25 88.3 0.7 1.1e-24 86.7 0.1 2.2 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Ank_2 PF12796.7 EMC86861.1 - 3.3e-09 37.2 0.0 1.2e-08 35.4 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC86861.1 - 1.8e-08 34.5 0.0 7.5e-08 32.5 0.0 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC86861.1 - 5.2e-08 33.3 0.0 6.9e-05 23.3 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EMC86861.1 - 0.0008 19.8 0.2 0.0091 16.4 0.0 2.8 3 0 0 3 3 3 1 Ankyrin repeat GAS PF13851.6 EMC86861.1 - 0.0046 16.3 0.8 0.0046 16.3 0.8 1.9 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding Ank_3 PF13606.6 EMC86861.1 - 0.0087 16.5 0.0 0.35 11.6 0.0 3.2 3 0 0 3 3 3 1 Ankyrin repeat Sen15 PF09631.10 EMC86861.1 - 0.012 15.9 0.1 0.065 13.5 0.0 2.3 2 0 0 2 2 2 0 Sen15 protein TTRAP PF14203.6 EMC86861.1 - 0.029 14.4 0.1 0.24 11.4 0.1 2.5 2 0 0 2 2 2 0 Putative tranposon-transfer assisting protein DMPK_coil PF08826.10 EMC86861.1 - 0.087 13.0 2.1 0.28 11.3 1.1 2.5 2 0 0 2 2 2 0 DMPK coiled coil domain like T7SS_ESX_EspC PF10824.8 EMC86861.1 - 0.12 12.8 5.1 1.2 9.7 0.1 3.9 4 0 0 4 4 4 0 Excreted virulence factor EspC, type VII ESX diderm Shugoshin_N PF07558.11 EMC86861.1 - 0.58 10.1 5.6 1.9 8.4 5.6 1.9 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region CRIC_ras_sig PF10534.9 EMC86861.1 - 4.3 7.6 9.8 0.35 11.1 0.2 4.0 5 1 0 5 5 5 0 Connector enhancer of kinase suppressor of ras TPH PF13868.6 EMC86862.1 - 8.5e-20 70.6 125.1 9.5e-20 70.4 125.1 1.0 1 0 0 1 1 1 1 Trichohyalin-plectin-homology domain GLTP PF08718.11 EMC86863.1 - 8.9e-34 116.9 0.0 1.2e-33 116.5 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) GN3L_Grn1 PF08701.11 EMC86863.1 - 0.032 14.3 0.9 0.062 13.4 0.3 1.7 2 0 0 2 2 2 0 GNL3L/Grn1 putative GTPase FliS PF02561.14 EMC86863.1 - 0.035 14.4 0.1 1.3 9.4 0.0 2.4 2 0 0 2 2 2 0 Flagellar protein FliS Ion_trans PF00520.31 EMC86864.1 - 7.5e-15 54.8 17.1 1e-14 54.4 17.1 1.1 1 0 0 1 1 1 1 Ion transport protein Ank_2 PF12796.7 EMC86864.1 - 2.6e-14 53.6 0.2 9.4e-06 26.1 0.0 3.2 2 2 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EMC86864.1 - 4e-10 39.7 0.1 0.00062 20.1 0.0 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 EMC86864.1 - 5.4e-10 38.6 0.1 0.0017 18.6 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 EMC86864.1 - 7.2e-08 32.8 0.3 0.012 16.2 0.0 3.8 1 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC86864.1 - 4.6e-07 30.0 0.2 0.25 11.7 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeats (many copies) FAM222A PF15258.6 EMC86865.1 - 4.5e-58 197.7 16.1 7.1e-44 150.8 2.2 3.2 2 1 1 3 3 3 3 Protein family of FAM222A Cob_adeno_trans PF01923.18 EMC86866.1 - 1.8e-44 151.7 0.0 2.1e-44 151.6 0.0 1.0 1 0 0 1 1 1 1 Cobalamin adenosyltransferase T2SSF PF00482.23 EMC86866.1 - 0.16 11.9 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F Hormone_3 PF00159.18 EMC86866.1 - 0.19 11.8 0.7 0.38 10.9 0.7 1.5 1 0 0 1 1 1 0 Pancreatic hormone peptide HECT PF00632.25 EMC86867.1 - 6.7e-94 314.8 0.0 1.6e-93 313.5 0.0 1.7 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 EMC86867.1 - 0.00036 20.1 2.1 0.0015 18.1 2.1 2.2 1 0 0 1 1 1 1 IQ calmodulin-binding motif Myosin_TH1 PF06017.13 EMC86868.1 - 1.7e-33 115.9 0.9 2.3e-33 115.5 0.9 1.1 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding Forkhead PF00250.18 EMC86869.1 - 5.4e-35 119.5 0.1 8.7e-35 118.9 0.1 1.3 1 0 0 1 1 1 1 Forkhead domain UDG PF03167.19 EMC86870.1 - 5.2e-24 85.0 0.0 8.4e-24 84.3 0.0 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Sugar_tr PF00083.24 EMC86871.1 - 1.7e-37 129.3 25.9 1e-24 87.3 8.9 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EMC86871.1 - 6.8e-36 123.9 38.3 2.6e-21 76.0 22.0 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EMC86871.1 - 0.0052 15.4 19.1 0.018 13.6 1.0 3.4 2 1 1 3 3 3 2 MFS/sugar transport protein DUF1899 PF08953.11 EMC86873.1 - 9e-32 108.8 0.0 1.7e-31 107.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 EMC86873.1 - 5.1e-22 77.5 0.1 9.6e-22 76.6 0.1 1.5 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 EMC86873.1 - 9.7e-15 54.7 6.9 3.5e-05 24.5 0.6 4.6 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC86873.1 - 1.7e-06 28.2 1.1 0.023 15.0 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC86873.1 - 0.0096 15.8 0.0 0.029 14.3 0.0 1.7 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A FIN1 PF17300.2 EMC86873.1 - 0.01 15.3 1.6 0.015 14.8 1.6 1.2 1 0 0 1 1 1 0 Filaments in between nuclei protein-1 PALB2_WD40 PF16756.5 EMC86873.1 - 0.11 11.4 0.1 0.18 10.7 0.1 1.4 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain MSP1a PF11670.8 EMC86874.1 - 0.03 13.6 0.1 0.035 13.4 0.1 1.2 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) DUF5549 PF17703.1 EMC86874.1 - 0.086 12.5 6.6 0.085 12.5 6.1 1.3 1 1 0 1 1 1 0 Family of unknown function (DUF5549) TMEM119 PF15724.5 EMC86875.1 - 2.3e-64 217.9 0.1 2.7e-64 217.7 0.1 1.0 1 0 0 1 1 1 1 TMEM119 family NICE-3 PF07406.11 EMC86875.1 - 0.012 15.6 0.1 0.018 15.0 0.1 1.2 1 0 0 1 1 1 0 NICE-3 protein DUF4064 PF13273.6 EMC86875.1 - 0.081 13.2 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) TMEM154 PF15102.6 EMC86875.1 - 0.12 12.3 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family NifU_N PF01592.16 EMC86876.1 - 5.9e-55 184.9 0.1 6.8e-55 184.7 0.1 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain Jag_N PF14804.6 EMC86876.1 - 0.14 12.6 2.3 6.3 7.2 0.0 2.6 3 0 0 3 3 3 0 Jag N-terminus RRM_1 PF00076.22 EMC86877.1 - 9e-32 108.7 0.1 2e-17 62.8 0.0 3.1 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LSM_int_assoc PF16605.5 EMC86877.1 - 7.3e-31 106.1 5.7 1.9e-30 104.8 5.7 1.8 1 0 0 1 1 1 1 LSM-interacting associated unstructured Lsm_interact PF05391.11 EMC86877.1 - 5.6e-07 28.8 2.0 1.3e-06 27.7 2.0 1.7 1 0 0 1 1 1 1 Lsm interaction motif RRM_occluded PF16842.5 EMC86877.1 - 5.8e-06 26.1 0.0 4.2e-05 23.3 0.0 2.2 2 0 0 2 2 2 1 Occluded RNA-recognition motif FAT PF02259.23 EMC86877.1 - 0.0034 16.6 4.2 0.0091 15.2 4.2 1.7 1 0 0 1 1 1 1 FAT domain Nup35_RRM_2 PF14605.6 EMC86877.1 - 0.0065 16.4 0.0 2 8.5 0.0 2.6 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif PPP4R2 PF09184.11 EMC86877.1 - 0.013 15.1 7.3 0.033 13.8 7.3 1.7 1 0 0 1 1 1 0 PPP4R2 RRM_7 PF16367.5 EMC86877.1 - 0.036 14.2 0.0 2.2 8.4 0.0 3.0 2 1 0 2 2 2 0 RNA recognition motif TPR_14 PF13428.6 EMC86877.1 - 0.063 14.1 16.6 16 6.6 0.4 7.0 6 1 1 7 7 7 0 Tetratricopeptide repeat DUF1993 PF09351.10 EMC86877.1 - 0.093 12.9 3.6 3.2 7.9 1.1 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF1993) RRM_5 PF13893.6 EMC86877.1 - 0.12 12.0 0.0 6.1 6.5 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CCDC71L PF15374.6 EMC86877.1 - 0.36 10.0 9.6 0.79 8.9 9.6 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L DUF3037 PF11236.8 EMC86877.1 - 0.5 10.8 8.0 36 4.8 0.0 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3037) Fic PF02661.18 EMC86878.1 - 6.3e-28 97.5 0.1 1.3e-27 96.5 0.1 1.6 1 0 0 1 1 1 1 Fic/DOC family TPR_2 PF07719.17 EMC86878.1 - 0.00064 19.6 0.6 0.016 15.3 0.4 2.9 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 EMC86878.1 - 0.0059 16.9 0.0 5.1 7.7 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EMC86878.1 - 0.014 15.1 3.0 1 9.1 0.0 2.9 3 1 1 4 4 4 0 TPR repeat TPR_16 PF13432.6 EMC86878.1 - 0.058 14.0 0.1 0.18 12.5 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat NiFe-hyd_HybE PF11939.8 EMC86878.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 [NiFe]-hydrogenase assembly, chaperone, HybE TPR_1 PF00515.28 EMC86878.1 - 0.68 9.9 2.4 7.2 6.6 0.7 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat Sulfotransfer_1 PF00685.27 EMC86879.1 - 1.2e-05 25.0 0.0 3.6e-05 23.4 0.0 1.8 1 1 0 2 2 2 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC86879.1 - 0.15 12.4 0.0 0.24 11.8 0.0 1.2 1 0 0 1 1 1 0 Sulfotransferase family C2 PF00168.30 EMC86881.1 - 1.2e-45 154.0 0.0 2.4e-21 76.0 0.0 2.3 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.16 EMC86881.1 - 2.5e-35 121.2 8.5 2.8e-35 121.1 7.2 1.8 2 0 0 2 2 2 1 FYVE-type zinc finger zf-piccolo PF05715.13 EMC86881.1 - 0.0019 18.3 11.5 0.0019 18.3 11.5 2.0 2 0 0 2 2 2 1 Piccolo Zn-finger PI3K_C2 PF00792.24 EMC86881.1 - 0.018 15.0 0.0 0.14 12.1 0.0 2.2 2 0 0 2 2 2 0 Phosphoinositide 3-kinase C2 MbtH PF03621.13 EMC86881.1 - 0.11 11.9 0.2 0.32 10.5 0.2 1.7 1 0 0 1 1 1 0 MbtH-like protein PHD PF00628.29 EMC86881.1 - 0.68 9.9 15.0 0.29 11.0 12.3 1.9 2 0 0 2 2 2 0 PHD-finger C1_1 PF00130.22 EMC86881.1 - 8.6 6.3 12.5 1 9.3 7.4 2.0 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Y_phosphatase PF00102.27 EMC86882.1 - 8.5e-83 277.5 0.8 1.5e-82 276.7 0.8 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase SH2 PF00017.24 EMC86882.1 - 3e-50 168.2 0.1 1.2e-23 83.0 0.0 2.7 2 0 0 2 2 2 2 SH2 domain DSPc PF00782.20 EMC86882.1 - 2e-05 24.4 1.4 9.6e-05 22.2 0.0 2.8 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC86882.1 - 0.0022 18.0 0.3 0.0067 16.4 0.0 1.8 2 1 0 2 2 2 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EMC86882.1 - 0.0071 16.5 0.0 0.0071 16.5 0.0 2.7 3 0 0 3 3 3 1 Inositol hexakisphosphate Ribosomal_L6e PF01159.19 EMC86883.1 - 8.6e-43 145.4 1.3 8.6e-43 145.4 1.3 2.7 2 1 1 3 3 3 1 Ribosomal protein L6e Ribosomal_L6e_N PF03868.15 EMC86883.1 - 1e-27 96.1 14.8 1e-27 96.1 14.8 2.9 3 0 0 3 3 3 1 Ribosomal protein L6, N-terminal domain P30 PF07390.11 EMC86883.1 - 0.03 14.4 0.1 0.03 14.4 0.1 1.6 2 0 0 2 2 2 0 Mycoplasma P30 protein DUF5097 PF17020.5 EMC86883.1 - 0.11 12.8 0.1 0.22 11.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5097) NatB_MDM20 PF09797.9 EMC86884.1 - 4.8e-124 414.2 0.6 4.8e-124 414.2 0.6 2.1 2 0 0 2 2 2 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_14 PF13428.6 EMC86884.1 - 0.00015 22.3 4.9 9.2 7.4 0.0 5.5 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMC86884.1 - 0.00081 19.9 4.3 0.67 10.5 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat BTAD PF03704.17 EMC86884.1 - 0.022 15.2 0.6 0.78 10.2 0.2 3.1 2 1 1 3 3 3 0 Bacterial transcriptional activator domain TPR_2 PF07719.17 EMC86884.1 - 0.13 12.4 3.3 12 6.3 0.1 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 EMC86884.1 - 0.29 11.6 1.4 1.5e+02 3.1 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC86884.1 - 0.83 9.9 12.5 15 5.9 0.7 4.1 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF3510 PF12022.8 EMC86884.1 - 0.97 9.8 6.2 6.6 7.1 0.1 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF3510) ERp29_N PF07912.13 EMC86885.1 - 4.5e-44 149.6 0.5 7.3e-44 149.0 0.5 1.3 1 0 0 1 1 1 1 ERp29, N-terminal domain ERp29 PF07749.12 EMC86885.1 - 4.8e-18 65.9 5.2 7.9e-18 65.2 5.2 1.4 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain PRTase_1 PF11202.8 EMC86885.1 - 0.016 14.5 1.5 0.025 13.8 1.5 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase (PRTase) GPR_Gpa2_C PF11970.8 EMC86886.1 - 0.00014 21.9 2.1 0.00037 20.5 2.1 1.7 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term Reprolysin PF01421.19 EMC86887.1 - 3.7e-53 180.4 0.4 7.2e-53 179.5 0.4 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 EMC86887.1 - 3.9e-33 114.3 6.1 3.9e-33 114.3 6.1 3.7 4 1 0 4 4 3 1 ADAM cysteine-rich Reprolysin_5 PF13688.6 EMC86887.1 - 1.1e-18 68.1 0.1 2.8e-18 66.8 0.1 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12 Disintegrin PF00200.23 EMC86887.1 - 2.1e-18 66.9 27.3 2.1e-18 66.9 27.3 3.9 4 1 0 4 4 3 1 Disintegrin Reprolysin_3 PF13582.6 EMC86887.1 - 3.8e-18 66.2 0.0 5.9e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EMC86887.1 - 1.2e-10 41.6 0.1 2.2e-10 40.8 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EMC86887.1 - 1e-09 38.4 0.0 1.7e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 EMC86887.1 - 0.0064 15.5 0.1 0.011 14.8 0.1 1.3 1 0 0 1 1 1 1 Peptidase M66 Peptidase_M10 PF00413.24 EMC86887.1 - 0.013 15.3 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 Matrixin ADAM_CR_2 PF17771.1 EMC86887.1 - 0.02 15.4 2.4 0.02 15.4 2.4 5.4 3 2 2 5 5 4 0 ADAM cysteine-rich domain Peptidase_M57 PF12388.8 EMC86887.1 - 0.068 12.8 0.3 0.12 12.0 0.3 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Peptidase_M54 PF07998.11 EMC86887.1 - 0.13 12.3 0.6 0.3 11.1 0.6 1.5 1 0 0 1 1 1 0 Peptidase family M54 Reprolysin PF01421.19 EMC86888.1 - 1.6e-47 162.0 0.0 1.6e-47 162.0 0.0 2.1 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 EMC86888.1 - 1.1e-33 116.1 3.9 1.1e-33 116.1 3.9 4.5 4 2 1 6 6 6 1 ADAM cysteine-rich Pep_M12B_propep PF01562.19 EMC86888.1 - 1.9e-22 80.0 0.0 3.8e-22 79.0 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Disintegrin PF00200.23 EMC86888.1 - 1.2e-17 64.5 29.2 1.2e-17 64.5 29.2 4.8 4 1 0 4 4 4 1 Disintegrin EGF_2 PF07974.13 EMC86888.1 - 0.00024 21.4 12.3 0.00024 21.4 12.3 7.3 8 0 0 8 8 8 2 EGF-like domain Pkinase PF00069.25 EMC86889.1 - 1.5e-61 208.1 0.0 3.1e-61 207.1 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC86889.1 - 7.3e-22 77.9 0.1 6.7e-21 74.7 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EMC86889.1 - 6e-05 22.5 0.2 0.00011 21.6 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EMC86889.1 - 6.6e-05 22.4 0.0 0.00014 21.3 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Choline_kinase PF01633.20 EMC86889.1 - 0.067 12.8 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 EMC86890.1 - 5.2e-39 134.6 0.0 8.5e-39 133.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family HAD_2 PF13419.6 EMC86890.1 - 3.5e-08 33.7 0.0 1.1e-07 32.1 0.0 1.8 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EMC86890.1 - 2.4e-05 24.7 0.0 4.2e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase EcKinase PF02958.20 EMC86890.1 - 0.0067 15.8 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Kdo PF06293.14 EMC86890.1 - 0.046 13.1 0.0 0.11 11.8 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EMC86890.1 - 0.064 12.8 0.0 1 8.9 0.0 2.2 2 0 0 2 2 2 0 RIO1 family BRAP2 PF07576.12 EMC86891.1 - 6.6e-36 122.5 0.8 1.4e-35 121.5 0.8 1.6 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 EMC86891.1 - 1.1e-20 73.7 7.1 1.1e-20 73.7 7.1 2.2 2 0 0 2 2 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 EMC86891.1 - 1.6e-08 34.7 7.0 1.6e-08 34.7 7.0 2.7 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC86891.1 - 9.5e-08 31.8 6.1 9.5e-08 31.8 6.1 2.4 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMC86891.1 - 8.4e-06 26.0 4.7 8.4e-06 26.0 4.7 2.6 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EMC86891.1 - 1.1e-05 25.0 1.8 1.1e-05 25.0 1.8 2.5 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_5 PF14634.6 EMC86891.1 - 2.6e-05 24.1 5.7 2.6e-05 24.1 5.7 2.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EMC86891.1 - 3.5e-05 23.7 0.5 3.5e-05 23.7 0.5 2.9 1 1 1 2 2 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EMC86891.1 - 7.5e-05 22.5 6.2 7.5e-05 22.5 6.2 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.22 EMC86891.1 - 0.00086 19.1 0.0 0.0018 18.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-ANAPC11 PF12861.7 EMC86891.1 - 0.005 16.8 3.1 0.02 14.9 3.1 2.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EMC86891.1 - 0.0062 16.4 18.3 0.032 14.1 7.7 2.6 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) KASH_CCD PF14662.6 EMC86891.1 - 0.0064 16.3 26.2 0.011 15.6 26.2 1.3 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH zf-C3H2C3 PF17122.5 EMC86891.1 - 0.038 14.0 4.2 0.18 11.9 4.2 2.3 1 0 0 1 1 1 0 Zinc-finger Atg14 PF10186.9 EMC86891.1 - 0.079 12.0 15.4 0.17 10.9 15.4 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Baculo_PEP_C PF04513.12 EMC86891.1 - 0.11 12.5 8.1 0.12 12.4 5.8 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus V_ATPase_I PF01496.19 EMC86891.1 - 0.11 10.4 16.2 0.41 8.5 11.9 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family FXMRP1_C_core PF12235.8 EMC86891.1 - 0.13 12.9 5.4 0.098 13.3 0.7 2.4 2 0 0 2 2 2 0 Fragile X-related 1 protein core C terminal Zn_ribbon_17 PF17120.5 EMC86891.1 - 0.18 11.5 15.0 0.21 11.2 5.6 2.7 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type FapA PF03961.13 EMC86891.1 - 0.22 10.1 14.7 0.34 9.4 14.7 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Vac_Fusion PF02346.16 EMC86891.1 - 0.26 10.9 3.5 0.93 9.2 0.7 2.8 1 1 1 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 Peptidase_S46 PF10459.9 EMC86891.1 - 0.26 9.9 7.6 0.37 9.4 7.6 1.2 1 0 0 1 1 1 0 Peptidase S46 DUF2935 PF11155.8 EMC86891.1 - 0.27 11.6 4.5 0.37 11.1 3.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) FUSC PF04632.12 EMC86891.1 - 0.39 9.2 0.6 0.55 8.7 0.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Prok-RING_4 PF14447.6 EMC86891.1 - 0.83 9.6 18.1 0.25 11.2 7.4 2.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 UPF0242 PF06785.11 EMC86891.1 - 0.84 9.7 23.7 1.5 8.9 23.7 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus GBP_C PF02841.14 EMC86891.1 - 0.93 8.8 23.3 0.2 11.0 19.1 1.9 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain NPV_P10 PF05531.12 EMC86891.1 - 1.1 9.7 8.1 8.5 6.9 5.8 3.2 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein eIF3_N PF09440.10 EMC86891.1 - 1.3 9.5 13.3 1.6 9.2 10.8 2.4 1 1 1 2 2 2 0 eIF3 subunit 6 N terminal domain Exonuc_VII_L PF02601.15 EMC86891.1 - 3.5 7.1 11.5 5.9 6.4 11.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit CREPT PF16566.5 EMC86891.1 - 4.3 7.5 20.2 1.6 8.9 11.8 3.0 2 1 1 3 3 2 0 Cell-cycle alteration and expression-elevated protein in tumour KELK PF15796.5 EMC86891.1 - 4.6 7.8 21.5 2.2 8.8 6.3 3.0 1 1 1 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF4407 PF14362.6 EMC86891.1 - 5.9 6.2 16.6 0.6 9.4 12.3 1.5 2 0 0 2 2 1 0 Domain of unknown function (DUF4407) TMPIT PF07851.13 EMC86891.1 - 8.7 5.5 14.0 16 4.6 14.0 1.4 1 0 0 1 1 1 0 TMPIT-like protein Phe_ZIP PF08916.11 EMC86893.1 - 5.1e-21 75.1 5.2 9.5e-21 74.3 5.2 1.5 1 0 0 1 1 1 1 Phenylalanine zipper SH2 PF00017.24 EMC86893.1 - 2e-09 37.4 0.1 4e-09 36.5 0.1 1.5 1 0 0 1 1 1 1 SH2 domain PH PF00169.29 EMC86893.1 - 2.7e-09 37.5 0.0 5e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 PH domain PH PF00169.29 EMC86894.1 - 3e-21 75.9 0.0 4.9e-21 75.2 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 EMC86894.1 - 2.3e-06 27.8 0.0 3.6e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EMC86894.1 - 0.00023 21.5 1.0 0.021 15.3 1.0 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 EMC86894.1 - 0.0017 18.6 0.0 0.0022 18.3 0.0 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH_13 PF16652.5 EMC86894.1 - 0.01 15.6 0.0 0.013 15.3 0.0 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain PH_4 PF15404.6 EMC86894.1 - 0.027 14.3 0.1 0.82 9.4 0.0 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain EF-hand_1 PF00036.32 EMC86895.1 - 1.3e-13 49.5 1.6 5.1e-06 25.7 0.9 4.1 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EMC86895.1 - 1.6e-09 36.9 1.5 2e-06 27.2 0.8 3.4 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.6 EMC86895.1 - 1.7e-08 34.1 2.6 0.0024 17.7 0.1 3.9 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_7 PF13499.6 EMC86895.1 - 5.1e-08 33.3 1.0 1.6e-05 25.2 0.8 2.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EMC86895.1 - 0.0017 17.7 1.0 0.0017 17.7 1.0 2.5 2 0 0 2 2 2 1 EF hand Caleosin PF05042.13 EMC86895.1 - 0.054 13.4 0.3 9.7 6.1 0.0 2.3 2 0 0 2 2 2 0 Caleosin related protein EF-hand_1 PF00036.32 EMC86896.1 - 1.3e-13 49.5 1.6 5.1e-06 25.7 0.9 4.1 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EMC86896.1 - 1.6e-09 36.9 1.5 2e-06 27.2 0.8 3.4 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.6 EMC86896.1 - 1.7e-08 34.1 2.6 0.0024 17.7 0.1 3.9 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_7 PF13499.6 EMC86896.1 - 5.1e-08 33.3 1.0 1.6e-05 25.2 0.8 2.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EMC86896.1 - 0.0017 17.7 1.0 0.0017 17.7 1.0 2.5 2 0 0 2 2 2 1 EF hand Caleosin PF05042.13 EMC86896.1 - 0.054 13.4 0.3 9.7 6.1 0.0 2.3 2 0 0 2 2 2 0 Caleosin related protein CbiA PF01656.23 EMC86897.1 - 1.9 8.6 5.1 0.78 9.8 2.0 2.0 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain ArfGap PF01412.18 EMC86897.1 - 2.2 8.4 7.9 4.4 7.4 3.1 3.2 1 1 1 3 3 3 0 Putative GTPase activating protein for Arf Metallophos PF00149.28 EMC86898.1 - 4.6e-41 141.6 0.1 5.7e-41 141.3 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EMC86898.1 - 5.1e-17 62.0 0.9 1.2e-16 60.9 0.5 1.8 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain VGPC1_C PF16799.5 EMC86899.1 - 1.2e-24 86.0 12.1 1.9e-24 85.3 12.1 1.3 1 0 0 1 1 1 1 C-terminal membrane-localisation domain of ion-channel, VCN1 Ion_trans PF00520.31 EMC86899.1 - 2.9e-06 26.7 7.4 3.9e-06 26.3 7.4 1.1 1 0 0 1 1 1 1 Ion transport protein CcdA PF07362.12 EMC86899.1 - 0.049 14.1 0.7 0.085 13.3 0.7 1.4 1 0 0 1 1 1 0 Post-segregation antitoxin CcdA TMF_DNA_bd PF12329.8 EMC86899.1 - 0.05 13.6 7.2 0.074 13.1 7.2 1.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding PLDc_2 PF13091.6 EMC86899.1 - 0.068 13.1 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 PLD-like domain DUF1619 PF07773.11 EMC86900.1 - 3.1e-82 277.0 5.4 9.8e-80 268.8 2.2 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF1619) SpoIIE PF07228.12 EMC86901.1 - 6.3e-15 55.6 0.0 8.7e-15 55.1 0.0 1.1 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 EMC86901.1 - 3.8e-06 26.7 1.0 3.6e-05 23.5 1.0 2.1 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 EMC86901.1 - 4e-05 23.4 0.1 0.01 15.5 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C Metallophos_2 PF12850.7 EMC86902.1 - 5.2e-22 78.8 0.1 6.3e-22 78.5 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 EMC86902.1 - 3.3e-05 24.5 1.3 0.13 12.7 0.2 2.3 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase Rod_C PF10493.9 EMC86903.1 - 8.5e-258 856.2 4.9 8.5e-258 856.2 4.9 2.3 2 0 0 2 2 2 1 Rough deal protein C-terminal region MRP-S22 PF10245.9 EMC86903.1 - 0.00099 18.9 0.3 0.0031 17.3 0.3 1.8 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S22 PSP PF04046.16 EMC86904.1 - 7.2e-17 61.0 0.3 1.7e-16 59.8 0.3 1.7 1 0 0 1 1 1 1 PSP zf-CCHC PF00098.23 EMC86904.1 - 2.8e-05 24.0 4.0 5.1e-05 23.2 4.0 1.5 1 0 0 1 1 1 1 Zinc knuckle CAP_GLY PF01302.25 EMC86905.1 - 1.2e-46 156.6 3.2 2.6e-24 85.0 0.5 2.3 2 0 0 2 2 2 2 CAP-Gly domain Fungal_TACC PF12709.7 EMC86905.1 - 5.5e-05 23.5 7.8 5.5e-05 23.5 7.8 16.0 3 2 10 15 15 15 2 Fungal Transforming acidic coiled-coil (TACC) proteins HTH_11 PF08279.12 EMC86905.1 - 0.01 15.8 0.2 0.25 11.3 0.0 3.4 2 0 0 2 2 2 1 HTH domain Sec1 PF00995.23 EMC86906.1 - 7.7e-124 415.0 0.0 8.6e-124 414.9 0.0 1.0 1 0 0 1 1 1 1 Sec1 family DUF1629 PF07791.11 EMC86906.1 - 0.046 13.9 0.0 0.096 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1629) Phage_HK97_TLTM PF06120.11 EMC86906.1 - 0.13 11.4 0.2 0.2 10.8 0.2 1.2 1 0 0 1 1 1 0 Tail length tape measure protein Galactosyl_T PF01762.21 EMC86907.1 - 9.2e-45 152.9 0.0 1.1e-44 152.6 0.0 1.0 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 EMC86907.1 - 2.9e-09 36.7 0.0 4.4e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Fringe-like LRR_8 PF13855.6 EMC86908.1 - 1.2e-10 41.0 6.5 0.015 15.0 4.7 3.7 2 1 1 3 3 3 3 Leucine rich repeat LRR_9 PF14580.6 EMC86908.1 - 3.8e-09 36.3 0.5 1e-06 28.3 0.0 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 EMC86908.1 - 1.7e-08 34.6 14.4 0.0026 18.1 0.1 4.0 2 2 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EMC86908.1 - 9.7e-05 22.1 2.7 0.18 12.0 0.5 5.2 6 0 0 6 6 6 1 Leucine Rich repeat LRR_1 PF00560.33 EMC86908.1 - 0.068 13.8 12.7 11 7.0 1.4 5.5 5 0 0 5 5 5 0 Leucine Rich Repeat HLH PF00010.26 EMC86909.1 - 2e-07 30.9 1.1 3.8e-07 30.0 0.2 2.1 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain ZapB PF06005.12 EMC86909.1 - 0.0017 18.8 3.3 0.0044 17.4 3.3 1.6 1 0 0 1 1 1 1 Cell division protein ZapB DivIC PF04977.15 EMC86909.1 - 0.013 15.2 2.9 0.026 14.3 2.9 1.4 1 0 0 1 1 1 0 Septum formation initiator FliJ PF02050.16 EMC86909.1 - 0.023 14.9 1.2 0.048 13.9 1.2 1.5 1 0 0 1 1 1 0 Flagellar FliJ protein Troponin PF00992.20 EMC86909.1 - 0.04 14.2 0.4 0.081 13.2 0.4 1.4 1 0 0 1 1 1 0 Troponin DUF5082 PF16888.5 EMC86909.1 - 0.066 13.5 1.3 0.12 12.7 1.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) HAP1_N PF04849.13 EMC86909.1 - 0.066 12.4 1.6 0.11 11.7 1.6 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region DUF4618 PF15397.6 EMC86909.1 - 0.093 12.1 2.4 0.17 11.3 2.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) TolA_bind_tri PF16331.5 EMC86909.1 - 0.16 12.1 4.2 0.35 11.0 4.2 1.5 1 0 0 1 1 1 0 TolA binding protein trimerisation bZIP_1 PF00170.21 EMC86909.1 - 0.25 11.5 3.1 0.61 10.2 3.0 1.6 1 1 0 1 1 1 0 bZIP transcription factor BCL_N PF04714.13 EMC86910.1 - 1.5e-10 41.0 1.7 3.6e-10 39.7 1.7 1.7 1 0 0 1 1 1 1 BCL7, N-terminal conserver region Defensin_propep PF00879.18 EMC86910.1 - 0.015 15.6 1.7 0.034 14.4 1.7 1.6 1 0 0 1 1 1 0 Defensin propeptide RR_TM4-6 PF06459.12 EMC86910.1 - 2.5 7.8 16.4 3.2 7.5 16.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 UPF0560 PF10577.9 EMC86910.1 - 5.1 5.5 17.7 6.1 5.2 17.7 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Nas2_N PF18265.1 EMC86911.1 - 1.7e-26 91.9 0.1 2.7e-26 91.3 0.1 1.3 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_2 PF13180.6 EMC86911.1 - 2.4e-10 40.6 0.0 3.9e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC86911.1 - 2.7e-09 36.7 0.2 4.6e-09 36.0 0.2 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 EMC86911.1 - 1.7e-07 31.5 0.1 2.5e-07 30.9 0.1 1.3 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 EMC86911.1 - 0.0003 21.1 0.0 0.00047 20.5 0.0 1.4 1 1 0 1 1 1 1 GRASP55/65 PDZ-like domain Glyoxalase PF00903.25 EMC86912.1 - 8.1e-22 77.8 0.6 2.7e-13 50.2 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EMC86912.1 - 4.6e-12 46.2 0.1 2e-06 28.0 0.1 2.4 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 EMC86912.1 - 0.00035 20.7 0.0 1.6 8.8 0.0 3.0 3 1 0 3 3 3 2 Glyoxalase-like domain Glyoxalase_5 PF14696.6 EMC86912.1 - 0.0014 18.8 0.1 0.0039 17.4 0.1 1.7 2 0 0 2 2 2 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal Rubella_E2 PF05749.11 EMC86913.1 - 0.00025 20.6 0.2 0.00025 20.6 0.2 1.4 2 0 0 2 2 2 1 Rubella membrane glycoprotein E2 Ras PF00071.22 EMC86915.1 - 1.2e-28 99.7 0.0 1.5e-28 99.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC86915.1 - 4.8e-07 30.0 0.0 1.4e-06 28.5 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase TMPIT PF07851.13 EMC86916.1 - 5e-150 499.2 17.5 5.8e-150 499.0 17.5 1.0 1 0 0 1 1 1 1 TMPIT-like protein MORN PF02493.20 EMC86917.1 - 6.9e-25 85.4 44.1 5e-05 22.9 2.7 6.8 7 0 0 7 7 7 6 MORN repeat Orai-1 PF07856.12 EMC86918.1 - 1.8e-54 184.1 2.5 2.1e-54 183.9 2.5 1.0 1 0 0 1 1 1 1 Mediator of CRAC channel activity 7TM_GPCR_Str PF10326.9 EMC86918.1 - 0.02 14.2 3.8 1.4 8.2 0.3 2.0 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Str DUF1345 PF07077.11 EMC86918.1 - 0.037 13.7 0.6 0.11 12.2 0.8 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1345) m04gp34like PF12216.8 EMC86918.1 - 0.085 12.4 0.2 0.92 9.0 0.0 2.0 1 1 1 2 2 2 0 Immune evasion protein DUF1772 PF08592.11 EMC86918.1 - 0.31 11.3 2.5 5.6 7.3 1.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) Neurensin PF14927.6 EMC86918.1 - 2 8.1 4.0 5.5 6.7 1.8 2.5 1 1 1 2 2 2 0 Neurensin PHD_4 PF16866.5 EMC86919.1 - 1.1e-26 92.7 9.6 1.1e-26 92.7 9.6 2.6 2 0 0 2 2 1 1 PHD-finger zf-CXXC PF02008.20 EMC86919.1 - 1.6e-14 53.7 21.5 1.6e-14 53.7 21.5 3.0 2 0 0 2 2 2 1 CXXC zinc finger domain F-box PF00646.33 EMC86919.1 - 2.6e-13 49.5 6.9 1.2e-12 47.3 1.7 2.7 2 0 0 2 2 2 1 F-box domain JHD PF17811.1 EMC86919.1 - 2.4e-12 47.3 3.0 2.1e-10 41.0 0.0 3.4 3 0 0 3 3 3 1 Jumonji helical domain F-box-like PF12937.7 EMC86919.1 - 8.1e-09 35.2 5.8 2.2e-08 33.8 5.8 1.8 1 0 0 1 1 1 1 F-box-like Cupin_8 PF13621.6 EMC86919.1 - 3e-07 30.4 1.6 2.4e-06 27.5 0.0 2.7 2 1 0 2 2 2 1 Cupin-like domain JmjC PF02373.22 EMC86919.1 - 7.2e-05 23.2 0.3 7.2e-05 23.2 0.3 3.2 3 1 0 3 3 2 1 JmjC domain, hydroxylase LRR_6 PF13516.6 EMC86919.1 - 0.0012 18.7 8.4 34 4.8 0.3 7.0 8 0 0 8 8 8 0 Leucine Rich repeat PHD PF00628.29 EMC86919.1 - 0.0068 16.3 8.1 0.0068 16.3 8.1 3.0 2 0 0 2 2 1 1 PHD-finger RbpA PF13397.6 EMC86919.1 - 0.011 16.3 0.6 0.12 13.0 0.1 2.5 2 0 0 2 2 2 0 RNA polymerase-binding protein LRR_4 PF12799.7 EMC86919.1 - 0.12 12.8 7.7 6.3 7.4 0.3 4.2 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) Viral_cys_rich PF08008.12 EMC86919.1 - 0.29 11.2 2.5 3 8.0 0.3 3.7 4 0 0 4 4 4 0 Viral cysteine rich 7tm_1 PF00001.21 EMC86920.1 - 1.8e-34 119.3 25.9 2.5e-34 118.8 25.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC86920.1 - 5e-10 39.2 25.9 6.6e-10 38.8 25.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC86920.1 - 0.0014 18.4 24.1 0.064 13.0 24.1 2.2 1 1 0 1 1 1 1 Olfactory receptor Pkinase PF00069.25 EMC86921.1 - 3.8e-65 219.9 0.0 2.4e-64 217.2 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC86921.1 - 8.5e-34 117.0 0.0 9e-32 110.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EMC86921.1 - 4.2e-08 32.9 0.0 6.3e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMC86921.1 - 5.3e-05 22.2 0.0 8.1e-05 21.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 EMC86921.1 - 0.0078 15.8 0.1 0.013 15.1 0.1 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 EMC86921.1 - 0.037 13.9 0.2 1.3 8.9 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EMC86921.1 - 0.23 10.5 0.4 2.7 6.9 0.0 2.2 2 0 0 2 2 2 0 Seadornavirus VP7 IFT81_CH PF18383.1 EMC86922.1 - 6.5e-51 171.8 0.1 6.5e-51 171.8 0.1 3.2 3 0 0 3 3 3 1 Intraflagellar transport 81 calponin homology domain Frankia_peptide PF14407.6 EMC86922.1 - 0.28 11.2 5.0 1.6 8.8 0.1 3.8 3 1 1 4 4 4 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. Osmo_CC PF08946.10 EMC86922.1 - 0.32 11.3 18.8 2.3 8.5 0.8 5.6 4 0 0 4 4 4 0 Osmosensory transporter coiled coil DUF948 PF06103.11 EMC86922.1 - 0.68 10.2 12.3 2.6 8.3 0.2 4.1 5 0 0 5 5 5 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.12 EMC86922.1 - 9.2 6.8 15.3 44 4.6 0.6 5.3 4 1 1 5 5 5 0 Nucleopolyhedrovirus P10 protein E1-E2_ATPase PF00122.20 EMC86924.1 - 1.2e-48 165.0 6.8 1.3e-47 161.7 0.3 2.9 3 0 0 3 3 3 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EMC86924.1 - 1.3e-45 155.4 2.3 1.3e-45 155.4 2.3 1.8 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 EMC86924.1 - 7.4e-21 74.1 0.3 1.5e-20 73.1 0.3 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EMC86924.1 - 3.3e-18 66.7 0.0 8.7e-17 62.1 0.0 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EMC86924.1 - 4e-17 61.7 1.4 2.3e-16 59.2 0.2 2.6 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EMC86924.1 - 1.8e-05 24.6 0.6 1.8e-05 24.6 0.6 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EMC86924.1 - 0.002 18.5 0.1 0.011 16.2 0.0 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase TPR_2 PF07719.17 EMC86925.1 - 4.8e-17 60.6 18.3 0.00043 20.2 0.0 9.5 9 1 1 10 10 9 4 Tetratricopeptide repeat TPR_14 PF13428.6 EMC86925.1 - 3.8e-14 52.2 8.3 0.3 12.0 0.0 8.6 6 1 4 10 10 9 3 Tetratricopeptide repeat TPR_19 PF14559.6 EMC86925.1 - 4.4e-13 49.5 10.1 0.0013 19.2 0.1 6.4 3 2 4 7 7 7 4 Tetratricopeptide repeat TPR_1 PF00515.28 EMC86925.1 - 2.9e-12 45.9 12.5 0.0045 16.8 0.0 8.1 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 EMC86925.1 - 5.9e-12 46.0 4.0 0.001 19.6 0.1 6.3 6 1 1 7 7 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMC86925.1 - 7.1e-12 44.6 7.5 0.14 12.4 0.0 7.6 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_7 PF13176.6 EMC86925.1 - 1.2e-07 31.2 8.1 0.12 12.4 0.0 6.9 7 1 0 7 7 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMC86925.1 - 5e-07 29.3 8.3 0.035 13.8 0.0 6.4 7 1 1 8 8 8 2 TPR repeat TPR_12 PF13424.6 EMC86925.1 - 2e-06 28.0 11.5 0.93 9.8 0.1 7.9 6 2 2 8 8 8 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMC86925.1 - 4.5e-05 23.8 10.4 3.6 8.4 0.0 7.6 9 0 0 9 9 9 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC86925.1 - 5.7e-05 23.3 15.1 0.11 12.8 0.5 6.0 5 2 1 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 ChAPs PF09295.10 EMC86925.1 - 0.00019 20.6 2.5 0.35 9.8 0.1 3.3 2 1 1 3 3 3 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_21 PF09976.9 EMC86925.1 - 0.00024 20.9 0.8 0.00024 20.9 0.8 2.7 4 0 0 4 4 4 1 Tetratricopeptide repeat-like domain TPR_10 PF13374.6 EMC86925.1 - 0.0062 16.4 1.6 0.22 11.4 0.2 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_20 PF14561.6 EMC86925.1 - 0.1 12.9 5.6 7.6 6.9 0.3 4.7 4 2 1 5 5 5 0 Tetratricopeptide repeat MAS20 PF02064.15 EMC86925.1 - 0.11 12.6 3.1 4.5 7.4 0.1 3.8 3 1 1 4 4 4 0 MAS20 protein import receptor DUF627 PF04781.12 EMC86925.1 - 0.26 11.3 2.5 9.2 6.3 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF627) TPR_17 PF13431.6 EMC86925.1 - 0.55 10.7 7.7 1.4e+02 3.2 0.1 6.4 8 0 0 8 8 6 0 Tetratricopeptide repeat P21-Arc PF04062.14 EMC86926.1 - 4.4e-81 271.1 0.1 4.9e-81 270.9 0.1 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit SUI1 PF01253.22 EMC86927.1 - 4.5e-17 62.4 0.1 7.7e-17 61.6 0.1 1.3 1 0 0 1 1 1 1 Translation initiation factor SUI1 CobA_CobO_BtuR PF02572.15 EMC86928.1 - 0.0058 16.9 2.7 0.0058 16.9 2.7 2.3 2 1 1 3 3 3 1 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP TMF_DNA_bd PF12329.8 EMC86928.1 - 0.02 14.9 5.5 0.02 14.9 5.5 5.0 3 1 2 5 5 5 0 TATA element modulatory factor 1 DNA binding HAP1_N PF04849.13 EMC86928.1 - 0.036 13.3 48.5 0.015 14.5 23.2 3.2 1 1 2 3 3 3 0 HAP1 N-terminal conserved region DUF4201 PF13870.6 EMC86928.1 - 5.5 6.7 49.2 0.071 12.8 12.8 3.4 1 1 1 3 3 3 0 Domain of unknown function (DUF4201) ANTH PF07651.16 EMC86930.1 - 3.6e-72 242.7 0.1 3.6e-72 242.7 0.1 2.6 2 1 0 2 2 2 1 ANTH domain HIP1_clath_bdg PF16515.5 EMC86930.1 - 2.3e-30 105.1 24.3 2.3e-30 105.1 24.3 5.9 5 2 0 5 5 5 1 Clathrin-binding domain of Huntingtin-interacting protein 1 I_LWEQ PF01608.17 EMC86930.1 - 4.6e-22 78.9 1.7 4.6e-22 78.9 1.7 5.5 3 1 2 5 5 5 1 I/LWEQ domain Nup54_57_C PF18570.1 EMC86930.1 - 0.16 11.5 6.2 0.35 10.5 0.2 3.5 2 0 0 2 2 2 0 NUP57/Nup54 C-terminal domain Golgin_A5 PF09787.9 EMC86930.1 - 0.82 9.1 72.3 0.17 11.3 13.9 4.2 2 1 2 4 4 4 0 Golgin subfamily A member 5 DUF3584 PF12128.8 EMC86930.1 - 1.1 6.7 61.0 0.042 11.4 50.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Spc7 PF08317.11 EMC86930.1 - 9.1 5.1 70.5 0.47 9.3 26.7 3.6 2 1 1 3 3 3 0 Spc7 kinetochore protein Mod_r PF07200.13 EMC86931.1 - 3.6e-32 111.5 9.4 4.8e-32 111.1 9.4 1.2 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein Cortex-I_coil PF09304.10 EMC86931.1 - 1.2 9.4 7.4 3.6 7.9 7.4 1.7 1 1 0 1 1 1 0 Cortexillin I, coiled coil ABC_membrane PF00664.23 EMC86932.1 - 1.7e-57 195.2 17.1 3.1e-57 194.3 17.1 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EMC86932.1 - 1.2e-33 116.5 0.0 2.7e-33 115.4 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EMC86932.1 - 1.3e-10 41.1 0.9 2.3e-07 30.5 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EMC86932.1 - 0.00044 20.2 0.0 0.00099 19.0 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 EMC86932.1 - 0.0007 19.9 0.0 0.0035 17.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain ABC_membrane_3 PF13748.6 EMC86932.1 - 0.00096 18.4 5.0 0.002 17.4 5.0 1.5 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_16 PF13191.6 EMC86932.1 - 0.0011 19.4 0.0 0.0028 18.0 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 EMC86932.1 - 0.018 14.8 0.0 0.039 13.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF4191 PF13829.6 EMC86932.1 - 0.037 13.4 0.0 0.037 13.4 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4191) MCU PF04678.13 EMC86932.1 - 0.053 13.6 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial calcium uniporter STN1_2 PF09170.10 EMC86932.1 - 0.11 12.7 0.4 0.33 11.2 0.4 1.7 1 0 0 1 1 1 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 AAA_15 PF13175.6 EMC86932.1 - 0.14 11.9 0.6 0.31 10.7 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain SbcCD_C PF13558.6 EMC86932.1 - 0.2 11.9 0.6 2.4 8.5 0.6 2.5 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_18 PF13238.6 EMC86932.1 - 0.22 12.1 1.0 7.4 7.1 0.0 2.7 2 1 1 3 3 2 0 AAA domain MFS_MOT1 PF16983.5 EMC86932.1 - 4.9 7.6 9.3 1.3 9.5 0.9 3.0 2 1 0 2 2 2 0 Molybdate transporter of MFS superfamily Integrase_H2C2 PF17921.1 EMC86933.1 - 3.5e-17 62.2 0.6 5e-17 61.8 0.6 1.2 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 EMC86933.1 - 2.1e-06 27.8 0.5 4.2e-06 26.9 0.5 1.5 1 0 0 1 1 1 1 H2C2 zinc finger SR-25 PF10500.9 EMC86935.1 - 5.5e-86 287.8 61.6 9e-86 287.2 61.6 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein PI3K_1B_p101 PF10486.9 EMC86935.1 - 1.6 6.4 29.7 2 6.1 29.7 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Hamartin PF04388.12 EMC86935.1 - 3.1 6.3 24.6 3.5 6.2 24.6 1.0 1 0 0 1 1 1 0 Hamartin protein IP_trans PF02121.18 EMC86936.1 - 1.9e-78 263.5 0.0 2e-78 263.4 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein MAD PF05557.13 EMC86937.1 - 0.00064 18.2 25.9 0.0013 17.2 25.9 1.4 1 0 0 1 1 1 1 Mitotic checkpoint protein GAS PF13851.6 EMC86937.1 - 0.00071 19.0 31.4 0.017 14.5 12.5 3.0 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding KASH_CCD PF14662.6 EMC86937.1 - 0.0022 17.9 30.0 0.15 11.9 18.9 2.8 1 1 1 2 2 2 2 Coiled-coil region of CCDC155 or KASH Filament PF00038.21 EMC86937.1 - 0.0024 17.5 29.9 0.093 12.3 9.9 3.5 1 1 3 4 4 4 3 Intermediate filament protein ATG16 PF08614.11 EMC86937.1 - 0.0063 16.8 11.0 0.0063 16.8 11.0 4.5 2 1 2 4 4 3 1 Autophagy protein 16 (ATG16) Myosin_tail_1 PF01576.19 EMC86937.1 - 0.0071 14.2 29.5 0.049 11.4 29.4 2.0 1 1 0 1 1 1 1 Myosin tail ADIP PF11559.8 EMC86937.1 - 0.01 15.9 43.5 0.05 13.7 6.4 4.6 2 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding Laminin_I PF06008.14 EMC86937.1 - 0.043 13.5 24.1 0.07 12.8 22.0 2.3 1 1 1 2 2 2 0 Laminin Domain I DUF1664 PF07889.12 EMC86937.1 - 0.074 13.1 15.8 0.039 14.0 2.6 3.2 2 1 0 3 3 2 0 Protein of unknown function (DUF1664) Prefoldin_2 PF01920.20 EMC86937.1 - 0.093 12.7 0.0 0.093 12.7 0.0 5.3 3 1 1 6 6 5 0 Prefoldin subunit BLOC1_2 PF10046.9 EMC86937.1 - 0.1 12.9 21.9 4.8 7.6 6.2 3.7 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.12 EMC86937.1 - 0.11 12.4 20.9 0.098 12.7 5.3 3.3 2 1 2 4 4 3 0 Laminin Domain II Spc7 PF08317.11 EMC86937.1 - 0.12 11.3 29.1 0.6 8.9 16.5 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein Tup_N PF08581.10 EMC86937.1 - 0.12 12.7 26.6 0.29 11.5 1.2 4.6 3 1 1 4 4 4 0 Tup N-terminal Lebercilin PF15619.6 EMC86937.1 - 0.14 11.8 40.3 0.12 12.0 12.6 3.1 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease IFT57 PF10498.9 EMC86937.1 - 0.15 11.0 34.1 0.008 15.2 12.0 3.1 2 1 1 3 3 3 0 Intra-flagellar transport protein 57 DUF745 PF05335.13 EMC86937.1 - 0.18 11.5 15.9 0.054 13.2 11.7 2.3 2 1 0 2 2 1 0 Protein of unknown function (DUF745) EzrA PF06160.12 EMC86937.1 - 0.29 9.2 23.9 0.6 8.2 23.9 1.5 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Syntaxin-6_N PF09177.11 EMC86937.1 - 0.34 11.5 21.8 6 7.5 4.8 4.3 1 1 2 3 3 3 0 Syntaxin 6, N-terminal SlyX PF04102.12 EMC86937.1 - 0.36 11.5 15.6 3.7 8.2 0.3 4.8 2 1 2 4 4 3 0 SlyX SHE3 PF17078.5 EMC86937.1 - 0.52 10.0 28.5 0.097 12.4 2.7 3.0 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 DUF3287 PF11690.8 EMC86937.1 - 0.62 9.8 5.0 0.38 10.5 0.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3287) Fib_alpha PF08702.10 EMC86937.1 - 0.93 9.7 25.7 0.23 11.6 10.4 3.9 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family TPR_MLP1_2 PF07926.12 EMC86937.1 - 1.2 9.2 41.1 0.07 13.2 8.7 3.9 2 1 2 4 4 3 0 TPR/MLP1/MLP2-like protein Occludin_ELL PF07303.13 EMC86937.1 - 2 9.2 21.7 2.6 8.8 1.1 4.3 2 1 2 4 4 3 0 Occludin homology domain Pox_A_type_inc PF04508.12 EMC86937.1 - 2.1 8.3 6.0 36 4.4 0.3 3.9 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat DUF4407 PF14362.6 EMC86937.1 - 2.9 7.2 24.9 2.9 7.2 16.3 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF812 PF05667.11 EMC86937.1 - 2.9 6.7 29.0 1.2 8.0 24.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF812) BST2 PF16716.5 EMC86937.1 - 3 8.5 26.5 7.7 7.2 3.6 5.1 1 1 2 4 4 4 0 Bone marrow stromal antigen 2 WXG100 PF06013.12 EMC86937.1 - 3.2 8.0 10.3 6.3 7.1 1.0 3.6 3 1 2 5 5 4 0 Proteins of 100 residues with WXG Exonuc_VII_L PF02601.15 EMC86937.1 - 3.8 7.0 30.6 4.3 6.8 13.9 3.5 2 2 1 3 3 3 0 Exonuclease VII, large subunit SpecificRecomb PF10136.9 EMC86937.1 - 3.9 5.7 6.6 7.7 4.7 6.6 1.5 1 0 0 1 1 1 0 Site-specific recombinase DHR10 PF18595.1 EMC86937.1 - 4.2 7.5 38.9 0.71 10.0 3.9 5.3 3 1 2 5 5 5 0 Designed helical repeat protein 10 domain Rab5-bind PF09311.11 EMC86937.1 - 4.2 6.7 30.3 1.1 8.6 14.7 3.2 2 1 1 3 3 2 0 Rabaptin-like protein Tropomyosin_1 PF12718.7 EMC86937.1 - 5.1 7.2 46.0 0.049 13.8 19.1 3.7 3 1 1 4 4 2 0 Tropomyosin like Gp-FAR-1 PF05823.12 EMC86937.1 - 5.8 7.3 14.6 0.98 9.8 8.1 2.9 2 1 1 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF4686 PF15742.5 EMC86937.1 - 6.2 5.8 32.9 0.79 8.8 26.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4686) Tugs PF17840.1 EMC86937.1 - 7.5 6.8 6.8 16 5.7 0.0 3.7 3 0 0 3 3 3 0 Tethering Ubl4a to BAGS domain DUF3450 PF11932.8 EMC86937.1 - 7.9 5.7 21.2 1.5 8.1 4.5 3.1 1 1 1 3 3 3 0 Protein of unknown function (DUF3450) RF-1 PF00472.20 EMC86938.1 - 2.7e-22 78.9 4.7 3.3e-22 78.6 4.7 1.1 1 0 0 1 1 1 1 RF-1 domain DUF2098 PF09871.9 EMC86938.1 - 0.15 12.4 3.2 0.2 12.0 3.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) CDK2AP PF09806.9 EMC86939.1 - 7e-20 72.1 0.1 9.3e-20 71.7 0.1 1.3 1 1 0 1 1 1 1 Cyclin-dependent kinase 2-associated protein DUF4248 PF14053.6 EMC86939.1 - 0.13 12.3 0.1 0.97 9.5 0.0 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4248) AAA_34 PF13872.6 EMC86940.1 - 1.4e-142 474.0 0.0 2.1e-142 473.4 0.0 1.3 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Helicase_C_4 PF13871.6 EMC86940.1 - 2.3e-125 417.7 0.0 3.6e-125 417.1 0.0 1.3 1 0 0 1 1 1 1 C-terminal domain on Strawberry notch homologue ResIII PF04851.15 EMC86940.1 - 1.1e-07 32.1 0.3 7.1e-07 29.4 0.0 2.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EMC86940.1 - 0.1 12.9 0.1 0.39 11.1 0.1 2.0 1 0 0 1 1 1 0 Helicase conserved C-terminal domain SET PF00856.28 EMC86941.1 - 3.7e-19 69.7 1.0 1.6e-18 67.7 0.1 2.2 2 1 0 2 2 2 1 SET domain SRP-alpha_N PF04086.13 EMC86941.1 - 0.11 12.4 6.9 0.14 12.0 6.9 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Phage_GPL PF05926.11 EMC86942.1 - 0.08 12.9 0.0 0.097 12.7 0.0 1.1 1 0 0 1 1 1 0 Phage head completion protein (GPL) RRM_1 PF00076.22 EMC86943.1 - 1.3e-17 63.4 0.1 2.2e-17 62.6 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RILP PF11461.8 EMC86944.1 - 4.8e-20 71.5 4.6 4.8e-20 71.5 4.6 2.8 3 1 0 3 3 3 1 Rab interacting lysosomal protein Jnk-SapK_ap_N PF09744.9 EMC86944.1 - 4.6e-13 49.7 7.2 4.6e-13 49.7 7.2 3.7 2 1 1 3 3 2 1 JNK_SAPK-associated protein-1 sCache_like PF16736.5 EMC86944.1 - 0.013 15.6 2.8 0.013 15.6 2.8 2.5 3 1 0 3 3 3 0 Single Cache-like YflT PF11181.8 EMC86944.1 - 0.023 15.2 1.6 0.11 13.1 1.6 2.3 1 1 0 1 1 1 0 Heat induced stress protein YflT TSC22 PF01166.18 EMC86944.1 - 0.068 13.5 0.8 0.068 13.5 0.8 4.3 4 1 1 5 5 4 0 TSC-22/dip/bun family FGAR-AT_linker PF18072.1 EMC86944.1 - 0.11 13.0 2.3 25 5.5 0.0 3.7 2 2 1 3 3 3 0 Formylglycinamide ribonucleotide amidotransferase linker domain Leu_zip PF15294.6 EMC86944.1 - 0.16 11.5 26.5 0.12 11.8 16.2 2.5 1 1 1 2 2 2 0 Leucine zipper E1_UFD PF09358.10 EMC86944.1 - 0.23 12.2 0.1 0.23 12.2 0.1 2.4 2 1 0 2 2 2 0 Ubiquitin fold domain DUF4407 PF14362.6 EMC86944.1 - 3 7.1 16.4 15 4.9 15.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) HrpB7 PF09486.10 EMC86944.1 - 8 6.8 15.9 3.8 7.9 2.3 2.8 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) DUF3450 PF11932.8 EMC86944.1 - 8.4 5.6 18.2 3.1 7.1 5.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Metal_resist PF13801.6 EMC86944.1 - 8.4 6.6 8.9 13 6.0 0.6 3.1 3 0 0 3 3 3 0 Heavy-metal resistance DEAD PF00270.29 EMC86945.1 - 3e-41 141.1 0.0 7.1e-41 139.9 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC86945.1 - 4.8e-24 84.9 0.0 2.2e-22 79.5 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EMC86945.1 - 5.8e-22 77.7 0.8 1.8e-21 76.1 0.8 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EMC86945.1 - 3.2e-06 27.3 3.7 4.9e-06 26.7 0.0 2.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit SBF_like PF13593.6 EMC86945.1 - 0.0051 16.2 0.0 0.0067 15.8 0.0 1.1 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) AAA_22 PF13401.6 EMC86945.1 - 0.01 16.1 0.1 0.034 14.4 0.1 2.0 1 1 0 1 1 1 0 AAA domain SurA_N_3 PF13624.6 EMC86945.1 - 0.16 11.8 4.2 0.3 10.8 4.2 1.4 1 0 0 1 1 1 0 SurA N-terminal domain Helicase_C_2 PF13307.6 EMC86945.1 - 0.18 12.0 1.9 0.22 11.7 0.0 2.1 2 0 0 2 2 2 0 Helicase C-terminal domain SHOCT PF09851.9 EMC86945.1 - 6.2 6.7 10.8 0.079 12.7 0.7 3.1 3 0 0 3 3 3 0 Short C-terminal domain RPN2_C PF18004.1 EMC86945.1 - 9.1 6.2 15.8 23 4.9 15.8 1.6 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain IF-2B PF01008.17 EMC86946.1 - 1e-70 238.1 0.0 1.2e-70 238.0 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family Tfb4 PF03850.14 EMC86947.1 - 3e-101 338.6 0.8 3.4e-101 338.3 0.8 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 CNOT1_CAF1_bind PF16415.5 EMC86947.1 - 0.097 12.0 0.5 0.15 11.4 0.5 1.2 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 1 CAF1-binding domain Baculo_IE-1 PF05290.11 EMC86947.1 - 2.1 8.3 8.2 0.63 10.0 4.7 1.9 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) DUF1619 PF07773.11 EMC86948.1 - 2.3e-59 201.9 3.7 1.2e-56 193.0 2.7 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1619) DHC_N1 PF08385.12 EMC86949.1 - 4.5e-131 438.3 16.9 5.1e-76 256.5 2.8 3.0 2 1 1 3 3 3 2 Dynein heavy chain, N-terminal region 1 STAT_alpha PF01017.20 EMC86949.1 - 0.36 10.7 8.1 2.8 7.8 0.0 4.3 4 0 0 4 4 4 0 STAT protein, all-alpha domain AAA_6 PF12774.7 EMC86950.1 - 5.8e-160 531.6 0.0 1.4e-157 523.8 0.0 3.0 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EMC86950.1 - 1.5e-132 442.5 10.8 1.5e-132 442.5 10.8 3.2 2 0 0 2 2 1 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 EMC86950.1 - 1.5e-101 339.1 0.0 4.4e-101 337.6 0.0 1.9 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 EMC86950.1 - 2e-84 282.2 1.9 1.7e-83 279.1 1.0 2.9 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_7 PF12775.7 EMC86950.1 - 4.8e-75 251.0 4.1 4.7e-70 234.8 0.2 3.6 3 0 0 3 3 3 2 P-loop containing dynein motor region Dynein_C PF18199.1 EMC86950.1 - 4e-57 193.8 0.5 3.1e-56 190.9 0.0 2.7 3 0 0 3 3 3 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 EMC86950.1 - 1.8e-55 187.2 0.2 6e-55 185.5 0.2 2.0 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MT PF12777.7 EMC86950.1 - 3.4e-48 164.5 14.7 6.3e-48 163.5 14.7 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 EMC86950.1 - 9.7e-42 141.8 0.0 8.9e-41 138.7 0.0 2.7 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain AAA_5 PF07728.14 EMC86950.1 - 1.7e-25 89.6 2.5 6.3e-07 29.5 0.0 6.2 5 1 0 5 5 4 4 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 EMC86950.1 - 8.6e-19 67.9 0.0 5.2e-18 65.4 0.0 2.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 EMC86950.1 - 9.7e-19 67.4 0.1 5.4e-18 65.0 0.1 2.4 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EMC86950.1 - 2.6e-11 43.9 0.1 0.032 14.5 0.0 5.3 4 0 0 4 4 4 3 AAA domain AAA PF00004.29 EMC86950.1 - 1.2e-07 32.3 5.5 0.86 10.0 0.0 5.8 6 0 0 6 6 5 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EMC86950.1 - 1.3e-05 25.7 5.7 2.7 8.3 0.0 6.1 7 1 1 8 8 5 2 AAA ATPase domain RsgA_GTPase PF03193.16 EMC86950.1 - 3.9e-05 23.6 0.1 0.0035 17.3 0.0 3.8 4 0 0 4 4 3 1 RsgA GTPase RNA_helicase PF00910.22 EMC86950.1 - 6.7e-05 23.2 0.1 4 7.9 0.0 3.8 3 0 0 3 3 3 1 RNA helicase AAA_18 PF13238.6 EMC86950.1 - 0.0001 22.9 0.4 0.54 10.8 0.0 4.5 4 0 0 4 4 3 1 AAA domain Cep57_CLD_2 PF14197.6 EMC86950.1 - 0.00027 21.0 3.7 0.00027 21.0 3.7 2.8 2 0 0 2 2 1 1 Centrosome localisation domain of PPC89 Sigma54_activat PF00158.26 EMC86950.1 - 0.00032 20.5 0.1 5.4 6.7 0.0 3.5 3 0 0 3 3 3 1 Sigma-54 interaction domain T2SSE PF00437.20 EMC86950.1 - 0.0058 15.7 0.0 0.74 8.8 0.0 2.8 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_29 PF13555.6 EMC86950.1 - 0.015 15.0 0.0 1.2 8.9 0.0 2.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_33 PF13671.6 EMC86950.1 - 0.021 15.0 1.3 22 5.2 0.1 4.2 4 0 0 4 4 4 0 AAA domain ABC_tran PF00005.27 EMC86950.1 - 0.043 14.3 0.2 2 8.9 0.1 3.6 3 0 0 3 3 3 0 ABC transporter Sigma54_activ_2 PF14532.6 EMC86950.1 - 0.14 12.3 1.4 7.1 6.8 0.0 3.8 3 0 0 3 3 3 0 Sigma-54 interaction domain DUF1515 PF07439.11 EMC86950.1 - 0.15 12.1 1.8 0.33 11.0 0.1 2.6 2 0 0 2 2 1 0 Protein of unknown function (DUF1515) ubiquitin PF00240.23 EMC86950.1 - 0.19 11.5 1.2 0.74 9.6 0.3 2.4 2 0 0 2 2 2 0 Ubiquitin family AcylCoA_dehyd_C PF12186.8 EMC86950.1 - 0.19 11.8 3.3 0.95 9.6 0.2 3.4 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase C terminal AAA_19 PF13245.6 EMC86950.1 - 0.41 11.0 3.0 69 3.7 0.1 4.1 3 0 0 3 3 3 0 AAA domain TsaE PF02367.17 EMC86950.1 - 1.8 8.6 4.6 58 3.7 0.2 3.9 4 0 0 4 4 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Plasmid_RAQPRD PF09686.10 EMC86950.1 - 1.8 8.8 4.4 4.2 7.6 0.0 3.6 3 1 0 3 3 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) CCDC92 PF14916.6 EMC86951.1 - 1.1e-23 82.8 12.5 1.4e-22 79.2 1.8 2.9 3 0 0 3 3 3 2 Coiled-coil domain of unknown function Angiomotin_C PF12240.8 EMC86951.1 - 0.00055 19.6 7.2 0.00055 19.6 7.2 2.0 1 1 0 1 1 1 1 Angiomotin C terminal Sigma54_DBD PF04552.13 EMC86951.1 - 0.0027 17.4 2.4 0.0027 17.4 2.4 1.6 2 0 0 2 2 2 1 Sigma-54, DNA binding domain CENP-F_leu_zip PF10473.9 EMC86951.1 - 0.0093 16.0 25.3 0.15 12.1 0.8 2.5 2 1 0 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4618 PF15397.6 EMC86951.1 - 0.013 14.9 1.0 0.013 14.9 1.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) UPF0242 PF06785.11 EMC86951.1 - 0.015 15.4 17.6 0.25 11.4 0.8 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Phage_GP20 PF06810.11 EMC86951.1 - 0.037 13.8 16.7 0.28 11.0 0.4 2.9 1 1 1 2 2 2 0 Phage minor structural protein GP20 TPR_MLP1_2 PF07926.12 EMC86951.1 - 0.073 13.1 0.9 0.073 13.1 0.9 3.2 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Mei5 PF10376.9 EMC86951.1 - 0.15 11.9 17.2 0.092 12.6 12.7 2.0 1 1 1 2 2 2 0 Double-strand recombination repair protein DUF4407 PF14362.6 EMC86951.1 - 0.24 10.7 8.8 0.42 9.9 8.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) KxDL PF10241.9 EMC86951.1 - 0.31 11.3 16.6 0.44 10.8 7.7 2.7 2 1 1 3 3 3 0 Uncharacterized conserved protein Nup54 PF13874.6 EMC86951.1 - 0.36 10.9 16.2 0.028 14.5 6.4 2.1 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 Golgin_A5 PF09787.9 EMC86951.1 - 0.41 10.1 18.9 0.41 10.1 0.8 2.0 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF3573 PF12097.8 EMC86951.1 - 0.51 9.1 2.8 0.7 8.7 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Atg14 PF10186.9 EMC86951.1 - 0.56 9.2 19.3 0.41 9.7 12.0 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 ATG16 PF08614.11 EMC86951.1 - 0.62 10.3 23.2 1.2 9.4 1.5 2.8 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) FlxA PF14282.6 EMC86951.1 - 0.84 9.7 16.7 0.57 10.2 3.1 3.3 1 1 3 4 4 4 0 FlxA-like protein Fez1 PF06818.15 EMC86951.1 - 0.91 9.9 19.0 1 9.8 14.0 2.2 1 1 1 2 2 2 0 Fez1 APG6_N PF17675.1 EMC86951.1 - 1.1 9.8 24.9 3.1 8.3 15.5 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region Lebercilin PF15619.6 EMC86951.1 - 1.1 8.8 27.8 44 3.7 27.0 2.9 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF641 PF04859.12 EMC86951.1 - 1.6 9.1 17.6 41 4.5 1.6 3.0 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DivIC PF04977.15 EMC86951.1 - 4.5 7.1 15.8 0.45 10.3 4.0 3.5 2 2 1 3 3 3 0 Septum formation initiator OmpH PF03938.14 EMC86951.1 - 5 7.5 19.1 9.8 6.5 11.2 2.4 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Spc7 PF08317.11 EMC86951.1 - 5.8 5.7 20.2 31 3.3 20.2 1.9 1 1 0 1 1 1 0 Spc7 kinetochore protein TMF_DNA_bd PF12329.8 EMC86951.1 - 5.8 7.0 25.5 33 4.6 4.2 3.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding HIP1_clath_bdg PF16515.5 EMC86951.1 - 7 7.3 22.8 12 6.6 1.4 3.0 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Pox_A_type_inc PF04508.12 EMC86951.1 - 8.2 6.5 8.8 2.9 7.9 0.3 3.8 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat FAM101 PF15068.6 EMC86952.1 - 1.7e-89 299.2 0.0 1.9e-89 299.0 0.0 1.0 1 0 0 1 1 1 1 FAM101 family ubiquitin PF00240.23 EMC86953.1 - 2.8e-105 344.2 10.1 2.7e-34 116.7 0.3 3.0 3 0 0 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.8 EMC86953.1 - 4.3e-51 170.6 10.7 2.9e-16 59.1 0.4 3.0 3 0 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EMC86953.1 - 2.3e-20 72.8 3.3 7e-05 23.2 0.1 4.5 3 3 0 3 3 3 3 Ubiquitin-like domain TBK1_ULD PF18396.1 EMC86953.1 - 1.2e-12 47.6 1.7 0.014 15.3 0.1 3.2 3 0 0 3 3 3 3 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EMC86953.1 - 7.2e-12 45.4 1.0 0.043 13.9 0.0 4.0 3 3 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EMC86953.1 - 1e-11 45.0 2.5 0.029 14.7 0.1 3.1 3 0 0 3 3 3 3 Ubiquitin-like domain DUF2407 PF10302.9 EMC86953.1 - 2.9e-09 37.4 0.1 0.38 11.4 0.0 3.2 1 1 1 3 3 3 3 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 EMC86953.1 - 1.1e-06 28.6 0.0 1.4 8.7 0.0 3.1 1 1 2 3 3 3 3 Silencing defective 2 N-terminal ubiquitin domain Ubiquitin_4 PF18036.1 EMC86953.1 - 4.2e-06 26.7 14.1 17 5.6 0.0 6.0 6 0 0 6 6 6 0 Ubiquitin-like domain DUF2870 PF11069.8 EMC86953.1 - 0.00023 21.5 0.1 20 5.6 0.0 3.8 3 3 0 3 3 3 0 Protein of unknown function (DUF2870) Methyltrans_RNA PF04452.14 EMC86953.1 - 0.00068 19.0 0.1 1.2 8.4 0.0 2.3 2 0 0 2 2 2 2 RNA methyltransferase RBD PF02196.15 EMC86953.1 - 0.00076 19.5 0.0 22 5.2 0.0 3.4 3 0 0 3 3 3 0 Raf-like Ras-binding domain UDP-g_GGTase PF06427.11 EMC86953.1 - 0.0018 18.3 2.0 3.4 7.8 0.0 3.2 4 0 0 4 4 3 2 UDP-glucose:Glycoprotein Glucosyltransferase DUF3861 PF12977.7 EMC86953.1 - 0.0019 18.3 0.4 27 5.0 0.0 3.2 3 0 0 3 3 3 0 Domain of Unknown Function with PDB structure (DUF3861) DUF969 PF06149.12 EMC86953.1 - 0.0066 15.9 0.0 14 5.0 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF969) FlgD_ig PF13860.6 EMC86953.1 - 0.019 14.8 2.4 39 4.2 0.1 3.4 3 0 0 3 3 3 0 FlgD Ig-like domain Big_7 PF17957.1 EMC86953.1 - 0.02 15.6 0.0 90 3.9 0.0 3.1 3 0 0 3 3 3 0 Bacterial Ig domain GDYXXLXY PF14345.6 EMC86953.1 - 0.053 13.3 0.1 75 3.1 0.0 3.3 3 0 0 3 3 3 0 GDYXXLXY protein Phage_sheath_1N PF17481.2 EMC86953.1 - 0.059 13.9 1.4 22 5.6 1.4 3.0 1 1 0 1 1 1 0 Phage tail sheath protein beta-sandwich domain CorA PF01544.18 EMC86953.1 - 0.059 12.7 0.1 51 3.0 0.0 3.0 3 0 0 3 3 3 0 CorA-like Mg2+ transporter protein ORF11CD3 PF10549.9 EMC86953.1 - 0.063 13.4 0.0 62 3.8 0.0 3.6 3 0 0 3 3 3 0 ORF11CD3 domain TraK PF06586.11 EMC86953.1 - 0.069 12.8 0.1 59 3.2 0.0 3.1 3 0 0 3 3 3 0 TraK protein ProRS-C_2 PF09181.10 EMC86953.1 - 0.086 13.0 1.1 89 3.3 0.0 3.1 3 0 0 3 3 3 0 Prolyl-tRNA synthetase, C-terminal DMA PF03474.14 EMC86953.1 - 0.25 11.0 1.5 72 3.1 0.0 3.3 3 0 0 3 3 3 0 DMRTA motif PI3K_p85B PF02192.16 EMC86953.1 - 1.3 8.8 3.4 1.1e+02 2.6 0.1 3.2 3 0 0 3 3 3 0 PI3-kinase family, p85-binding domain HA2 PF04408.23 EMC86954.1 - 2.1e-24 85.9 0.0 2.1e-24 85.9 0.0 2.6 3 0 0 3 3 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EMC86954.1 - 3e-23 82.0 0.0 6.7e-23 80.9 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 EMC86954.1 - 7.1e-12 45.4 0.1 7.1e-12 45.4 0.1 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC86954.1 - 6e-10 39.5 0.1 7.6e-07 29.5 0.0 3.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EMC86954.1 - 2e-06 28.1 0.1 1.2e-05 25.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EMC86954.1 - 2.5e-05 24.6 0.0 6.8e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EMC86954.1 - 7.3e-05 22.6 0.0 0.00018 21.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 EMC86954.1 - 0.0037 17.3 1.0 0.045 13.7 0.0 2.8 3 0 0 3 3 3 1 Flavivirus DEAD domain T2SSE PF00437.20 EMC86954.1 - 0.0076 15.3 0.0 0.022 13.8 0.0 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_23 PF13476.6 EMC86954.1 - 0.016 15.7 10.9 0.25 11.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EMC86954.1 - 0.017 14.5 0.0 0.033 13.5 0.0 1.4 1 0 0 1 1 1 0 KaiC ResIII PF04851.15 EMC86954.1 - 0.031 14.3 4.3 0.043 13.8 0.2 2.8 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_5 PF07728.14 EMC86954.1 - 0.041 13.9 0.2 6.9 6.7 0.1 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 EMC86954.1 - 0.78 10.3 2.8 5.4 7.5 0.1 2.8 2 1 0 3 3 3 0 ABC transporter BRI3BP PF14965.6 EMC86955.1 - 3.8e-73 244.8 0.4 4.3e-73 244.7 0.4 1.0 1 0 0 1 1 1 1 Negative regulator of p53/TP53 CLZ PF16526.5 EMC86955.1 - 0.018 15.4 0.1 0.11 12.8 0.0 1.9 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels MgtE PF01769.16 EMC86955.1 - 0.057 13.8 2.9 0.08 13.3 2.9 1.3 1 0 0 1 1 1 0 Divalent cation transporter AMP-binding PF00501.28 EMC86956.1 - 1e-43 149.6 0.0 1.5e-43 149.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EMC86956.1 - 1.7e-10 40.6 2.3 4.2e-10 39.4 2.3 1.7 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus TMEM132D_N PF15705.5 EMC86957.1 - 9.5e-57 190.5 0.0 1.6e-56 189.8 0.0 1.4 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, N-term TMEM132 PF16070.5 EMC86957.1 - 1.3e-16 60.9 3.3 2.1e-16 60.2 3.3 1.3 1 0 0 1 1 1 1 Transmembrane protein family 132 TMEM132 PF16070.5 EMC86958.1 - 6.9e-125 417.0 0.7 8.9e-125 416.6 0.7 1.1 1 0 0 1 1 1 1 Transmembrane protein family 132 TMEM132D_C PF15706.5 EMC86958.1 - 4.2e-34 116.2 0.7 8.2e-34 115.2 0.0 1.9 2 0 0 2 2 2 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term TMEM132 PF16070.5 EMC86959.1 - 2.2e-152 507.4 4.9 3.6e-152 506.6 4.9 1.4 1 0 0 1 1 1 1 Transmembrane protein family 132 TMEM132D_N PF15705.5 EMC86959.1 - 1.7e-60 202.6 0.5 6e-60 200.8 0.2 2.2 2 0 0 2 2 2 1 Mature oligodendrocyte transmembrane protein, TMEM132D, N-term TMEM132D_C PF15706.5 EMC86959.1 - 3.2e-25 87.7 0.0 6.3e-25 86.8 0.0 1.5 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term PTR2 PF00854.21 EMC86960.1 - 5.3e-113 377.8 8.2 7e-113 377.4 8.2 1.1 1 0 0 1 1 1 1 POT family MFS_1 PF07690.16 EMC86960.1 - 8.5e-10 38.1 11.4 8.5e-10 38.1 11.4 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Glycos_transf_1 PF00534.20 EMC86961.1 - 1.4e-21 76.8 0.0 2.1e-21 76.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EMC86961.1 - 6.3e-16 59.0 0.0 1.1e-15 58.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EMC86961.1 - 7e-08 32.8 0.0 1.5e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 TMEM132 PF16070.5 EMC86962.1 - 3.9e-155 516.4 2.8 5.2e-155 516.0 2.8 1.2 1 0 0 1 1 1 1 Transmembrane protein family 132 TMEM132D_C PF15706.5 EMC86962.1 - 7.4e-36 121.8 0.0 1.6e-35 120.7 0.0 1.6 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term TMEM132D_N PF15705.5 EMC86963.1 - 5.6e-60 200.9 0.1 6.6e-60 200.7 0.1 1.1 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, N-term Frizzled PF01534.17 EMC86964.1 - 4.8e-139 462.9 23.2 6.3e-139 462.5 23.2 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 EMC86964.1 - 5.2e-32 110.8 4.6 1.4e-31 109.4 4.6 1.8 1 0 0 1 1 1 1 Fz domain Piwi PF02171.17 EMC86965.1 - 4.8e-107 357.7 0.0 7.5e-107 357.1 0.0 1.3 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 EMC86965.1 - 1.7e-35 121.8 0.5 3.8e-35 120.7 0.5 1.6 1 0 0 1 1 1 1 PAZ domain ArgoN PF16486.5 EMC86965.1 - 1.1e-07 32.6 0.0 3.5e-07 30.9 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 EMC86965.1 - 2.6e-05 23.8 0.0 6.3e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain GAGE PF05831.11 EMC86965.1 - 0.0012 19.4 0.0 0.0026 18.3 0.0 1.6 2 0 0 2 2 2 1 GAGE protein Calici_coat PF00915.20 EMC86965.1 - 0.18 10.7 0.0 0.3 10.0 0.0 1.2 1 0 0 1 1 1 0 Calicivirus coat protein SH3_2 PF07653.17 EMC86966.1 - 1.3e-32 111.2 0.0 2.1e-10 40.1 0.0 3.4 3 0 0 3 3 3 3 Variant SH3 domain SH3_9 PF14604.6 EMC86966.1 - 1.1e-27 95.7 3.4 3.6e-12 45.9 0.1 3.8 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.28 EMC86966.1 - 4.1e-16 58.3 0.1 1.9e-06 27.3 0.0 3.9 3 1 0 3 3 3 3 SH3 domain fn3 PF00041.21 EMC86966.1 - 1e-12 48.2 4.8 0.0003 21.1 0.2 4.3 3 1 0 3 3 3 3 Fibronectin type III domain DUF4527 PF15030.6 EMC86966.1 - 1.3 8.4 10.5 2.9 7.2 10.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4527) CENP-H PF05837.12 EMC86966.1 - 3.6 8.0 9.4 11 6.5 9.4 1.9 1 0 0 1 1 1 0 Centromere protein H (CENP-H) ADIP PF11559.8 EMC86966.1 - 4.8 7.3 12.1 9.7 6.3 12.1 1.5 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Syntaxin PF00804.25 EMC86967.1 - 6.4e-62 208.8 18.0 6.4e-62 208.8 18.0 1.6 2 0 0 2 2 2 1 Syntaxin SNARE PF05739.19 EMC86967.1 - 3.7e-19 68.4 1.7 3.7e-19 68.4 1.7 2.3 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.6 EMC86967.1 - 1e-11 45.1 5.8 1e-11 45.1 5.8 2.7 1 1 1 2 2 2 1 Syntaxin-like protein T2SSF PF00482.23 EMC86967.1 - 0.0016 18.4 5.0 0.019 14.9 0.8 2.7 2 1 0 2 2 2 1 Type II secretion system (T2SS), protein F DUF3671 PF12420.8 EMC86967.1 - 0.0018 18.3 1.7 0.0028 17.7 0.2 2.0 2 0 0 2 2 1 1 Protein of unknown function COG5 PF10392.9 EMC86967.1 - 0.012 15.8 9.3 0.44 10.7 1.2 2.7 2 2 0 2 2 2 0 Golgi transport complex subunit 5 Baculo_PEP_C PF04513.12 EMC86967.1 - 0.013 15.6 2.4 0.51 10.4 0.2 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF16 PF01519.16 EMC86967.1 - 0.016 15.7 0.8 0.016 15.7 0.8 3.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF4855 PF16147.5 EMC86967.1 - 0.033 13.3 0.5 0.033 13.3 0.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4855) DUF1845 PF08900.11 EMC86967.1 - 0.038 13.7 4.2 0.04 13.7 0.1 2.7 3 1 1 4 4 4 0 Domain of unknown function (DUF1845) PBP1_TM PF14812.6 EMC86967.1 - 0.057 13.8 0.6 0.15 12.4 0.1 2.0 2 0 0 2 2 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Mur_ligase_M PF08245.12 EMC86967.1 - 0.12 12.4 7.2 0.091 12.7 0.8 2.3 2 0 0 2 2 2 0 Mur ligase middle domain DUF2205 PF10224.9 EMC86967.1 - 0.13 12.3 0.2 0.13 12.3 0.2 3.8 4 0 0 4 4 4 0 Short coiled-coil protein DUF677 PF05055.12 EMC86967.1 - 0.13 11.1 14.1 0.092 11.6 3.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF677) NPV_P10 PF05531.12 EMC86967.1 - 0.15 12.5 4.3 15 6.2 0.1 3.0 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein AAA_13 PF13166.6 EMC86967.1 - 0.16 10.6 19.9 0.52 8.9 19.8 1.7 1 1 0 1 1 1 0 AAA domain Lipase_GDSL PF00657.22 EMC86967.1 - 0.2 11.6 3.3 0.2 11.6 1.5 1.8 1 1 1 2 2 2 0 GDSL-like Lipase/Acylhydrolase Mrr_N PF14338.6 EMC86967.1 - 0.25 11.5 0.1 0.25 11.5 0.1 2.5 4 0 0 4 4 1 0 Mrr N-terminal domain LPP PF04728.13 EMC86967.1 - 0.26 11.7 11.6 9.3 6.7 0.2 3.8 3 1 0 3 3 3 0 Lipoprotein leucine-zipper Serine_rich PF08824.10 EMC86967.1 - 0.32 11.0 4.2 0.45 10.5 0.7 2.3 2 0 0 2 2 2 0 Serine rich protein interaction domain FapA PF03961.13 EMC86967.1 - 0.39 9.3 18.9 0.0069 15.0 7.6 2.1 1 1 0 2 2 2 0 Flagellar Assembly Protein A Syntaxin-6_N PF09177.11 EMC86967.1 - 0.4 11.3 14.0 0.057 14.0 2.1 2.9 1 1 1 2 2 2 0 Syntaxin 6, N-terminal TipAS PF07739.13 EMC86967.1 - 0.47 11.0 5.2 11 6.6 0.3 2.7 2 2 0 2 2 2 0 TipAS antibiotic-recognition domain Mer2 PF09074.10 EMC86967.1 - 0.81 9.5 17.1 0.054 13.3 2.5 2.7 1 1 1 2 2 2 0 Mer2 FH2 PF02181.23 EMC86967.1 - 1 8.4 14.4 1.5 7.9 1.1 3.1 2 1 0 3 3 3 0 Formin Homology 2 Domain MCPsignal PF00015.21 EMC86967.1 - 1.3 8.8 13.5 1.1 9.1 0.9 3.4 1 1 4 5 5 5 0 Methyl-accepting chemotaxis protein (MCP) signalling domain TSC22 PF01166.18 EMC86967.1 - 1.8 8.9 8.7 2.4 8.5 0.1 3.1 3 0 0 3 3 3 0 TSC-22/dip/bun family WXG100 PF06013.12 EMC86967.1 - 1.9 8.8 7.9 12 6.2 0.2 3.8 4 1 1 5 5 4 0 Proteins of 100 residues with WXG HSCB_C PF07743.13 EMC86967.1 - 2.3 8.8 13.3 0.11 13.0 1.6 3.7 3 1 0 3 3 3 0 HSCB C-terminal oligomerisation domain TMPIT PF07851.13 EMC86967.1 - 2.3 7.4 14.2 2 7.6 3.4 2.2 1 1 1 2 2 2 0 TMPIT-like protein DUF848 PF05852.11 EMC86967.1 - 2.6 8.1 15.3 0.12 12.4 4.8 2.7 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) KIP1 PF07765.12 EMC86967.1 - 2.7 8.2 12.6 5.9 7.1 1.3 3.7 3 1 1 4 4 4 0 KIP1-like protein DUF2207 PF09972.9 EMC86967.1 - 2.8 6.6 7.1 0.24 10.1 0.9 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) DUF1664 PF07889.12 EMC86967.1 - 2.8 8.0 14.7 19 5.3 0.2 3.9 2 2 1 4 4 4 0 Protein of unknown function (DUF1664) MCU PF04678.13 EMC86967.1 - 2.9 8.0 13.8 3.8 7.6 4.5 2.4 1 1 1 2 2 2 0 Mitochondrial calcium uniporter Sec34 PF04136.15 EMC86967.1 - 3.1 7.7 11.8 0.75 9.7 3.8 2.9 2 1 1 3 3 3 0 Sec34-like family Allexi_40kDa PF05549.11 EMC86967.1 - 3.1 7.2 10.8 1.1 8.7 1.8 2.2 1 1 0 2 2 2 0 Allexivirus 40kDa protein K-box PF01486.17 EMC86967.1 - 3.7 7.8 12.3 0.42 10.8 4.0 2.8 2 2 1 3 3 3 0 K-box region FlxA PF14282.6 EMC86967.1 - 3.9 7.5 10.9 1.1 9.2 2.7 2.8 2 1 0 2 2 2 0 FlxA-like protein ISG65-75 PF11727.8 EMC86967.1 - 4.9 6.3 12.3 1.5 8.0 2.5 2.7 2 1 1 3 3 3 0 Invariant surface glycoprotein TSNAXIP1_N PF15739.5 EMC86967.1 - 6.6 7.1 12.0 0.7 10.3 1.8 3.0 2 1 1 3 3 3 0 Translin-associated factor X-interacting N-terminus DUF883 PF05957.13 EMC86967.1 - 7 7.3 7.9 6.2 7.5 1.9 3.2 2 2 0 2 2 2 0 Bacterial protein of unknown function (DUF883) FlaC_arch PF05377.11 EMC86967.1 - 7.1 7.1 16.6 4.8 7.6 0.3 4.4 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Laminin_II PF06009.12 EMC86967.1 - 8.2 6.5 17.4 10 6.2 1.1 3.8 1 1 2 4 4 4 0 Laminin Domain II PCRF PF03462.18 EMC86967.1 - 8.7 6.2 17.8 1.5 8.7 2.3 2.8 1 1 2 3 3 3 0 PCRF domain 7tm_2 PF00002.24 EMC86968.1 - 2.5e-51 174.4 20.0 2.5e-51 174.4 20.0 1.8 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) Laminin_G_3 PF13385.6 EMC86968.1 - 1.7e-15 57.5 0.0 2.9e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily GPS PF01825.21 EMC86968.1 - 1.5e-12 47.8 2.0 1.5e-12 47.8 2.0 2.0 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif Mycobact_memb PF05423.13 EMC86968.1 - 0.042 13.8 0.9 0.087 12.8 0.1 1.9 2 0 0 2 2 2 0 Mycobacterium membrane protein DUF2673 PF10880.8 EMC86968.1 - 0.16 12.1 0.0 0.38 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2673) Peptidase_M10 PF00413.24 EMC86969.1 - 7.5e-50 168.9 0.5 1.6e-49 167.8 0.5 1.6 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 EMC86969.1 - 1.1e-40 137.3 19.6 4.8e-12 45.6 0.2 5.1 5 0 0 5 5 5 4 Hemopexin PG_binding_1 PF01471.18 EMC86969.1 - 5.8e-13 48.8 0.2 1.5e-12 47.5 0.2 1.8 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.24 EMC86969.1 - 0.03 13.9 1.7 0.53 9.9 0.9 2.3 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Peptidase_M66 PF10462.9 EMC86969.1 - 0.039 12.9 0.1 0.067 12.1 0.1 1.3 1 0 0 1 1 1 0 Peptidase M66 Pkinase PF00069.25 EMC86970.1 - 4.4e-64 216.4 2.9 7.2e-64 215.7 0.1 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC86970.1 - 6.3e-46 156.8 0.1 1.2e-45 155.9 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3543 PF12063.8 EMC86970.1 - 2.1e-25 89.5 7.4 5.2e-25 88.3 7.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Kdo PF06293.14 EMC86970.1 - 1.2e-06 28.0 0.0 2.4e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EMC86970.1 - 0.00022 20.9 0.1 0.00041 20.0 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 EMC86970.1 - 0.00056 19.3 0.0 0.0019 17.6 0.0 1.8 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMC86970.1 - 0.0018 17.2 0.0 0.0033 16.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMC86970.1 - 0.013 15.4 0.0 0.075 12.9 0.0 2.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family CBF PF03914.17 EMC86971.1 - 5.1e-37 127.5 1.6 5.1e-37 127.5 1.6 1.5 2 0 0 2 2 2 1 CBF/Mak21 family Muted PF14942.6 EMC86971.1 - 0.048 14.0 1.1 2 8.8 0.2 2.2 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein Glycos_transf_2 PF00535.26 EMC86972.1 - 3.5e-26 92.0 0.1 7.1e-26 91.0 0.1 1.5 2 0 0 2 2 2 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 EMC86972.1 - 1.9e-20 73.4 0.0 3e-20 72.7 0.0 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 EMC86972.1 - 7.6e-07 29.2 0.0 8e-06 25.9 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 EMC86972.1 - 0.0061 16.2 0.0 0.016 14.8 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Auts2 PF15336.6 EMC86973.1 - 1.1e-110 368.9 11.7 1.1e-110 368.9 11.7 5.8 6 0 0 6 6 6 3 Autism susceptibility gene 2 protein LEM PF03020.15 EMC86975.1 - 2.3e-10 39.9 0.0 5.5e-10 38.6 0.0 1.6 1 0 0 1 1 1 1 LEM domain Ank_5 PF13857.6 EMC86975.1 - 7.4e-09 35.7 0.0 0.0022 18.3 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC86975.1 - 1e-08 35.6 0.0 1.7e-05 25.3 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Cauli_VI PF01693.16 EMC86975.1 - 8.3e-05 22.8 0.2 0.00025 21.3 0.2 1.8 1 0 0 1 1 1 1 Caulimovirus viroplasmin Ank_4 PF13637.6 EMC86975.1 - 0.00022 21.7 0.0 0.0011 19.4 0.0 2.1 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC86975.1 - 0.00034 20.8 0.1 0.11 13.1 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 EMC86975.1 - 0.0031 17.9 0.0 0.29 11.7 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat DUF406 PF04175.12 EMC86975.1 - 0.047 14.2 0.1 0.2 12.2 0.1 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF406) Reticulon PF02453.17 EMC86976.1 - 0.013 15.5 1.2 0.026 14.5 1.2 1.5 1 0 0 1 1 1 0 Reticulon Pex24p PF06398.11 EMC86976.1 - 0.062 12.3 0.0 0.11 11.4 0.0 1.4 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Tic110 PF16940.5 EMC86976.1 - 0.12 10.9 0.0 0.16 10.4 0.0 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter zf-C2H2_2 PF12756.7 EMC86977.1 - 6.8e-36 122.6 10.4 1.2e-28 99.4 0.3 3.4 2 1 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EMC86977.1 - 2.3e-11 43.7 14.6 4.1e-07 30.1 3.8 3.7 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC86977.1 - 4.5e-05 23.7 3.4 4.5e-05 23.7 3.4 3.6 4 0 0 4 4 4 1 Zinc-finger of C2H2 type DUF629 PF04780.12 EMC86977.1 - 0.0024 16.5 3.6 0.047 12.2 0.9 2.6 1 1 1 2 2 2 2 Protein of unknown function (DUF629) DUF4637 PF15470.6 EMC86977.1 - 0.0027 17.5 0.5 0.0062 16.3 0.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4637) zf-C2H2_4 PF13894.6 EMC86977.1 - 0.0077 17.0 0.8 0.0077 17.0 0.8 4.3 4 0 0 4 4 4 1 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC86977.1 - 0.0082 16.1 1.7 0.0082 16.1 1.7 2.3 2 0 0 2 2 2 1 C2H2-type zinc finger zf-DBF PF07535.12 EMC86977.1 - 0.049 13.8 7.9 0.053 13.6 0.9 3.0 3 0 0 3 3 3 0 DBF zinc finger zf-LYAR PF08790.11 EMC86977.1 - 0.071 13.0 7.4 2.3 8.2 0.2 3.3 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger DNA_pol_phi PF04931.13 EMC86977.1 - 4.2 5.3 14.2 0.2 9.7 7.7 1.8 2 0 0 2 2 2 0 DNA polymerase phi RINGv PF12906.7 EMC86978.1 - 2.9e-10 40.1 3.7 8.6e-10 38.6 3.7 1.8 1 0 0 1 1 1 1 RING-variant domain ABC_cobalt PF09819.9 EMC86978.1 - 0.026 14.6 2.3 0.041 14.0 2.3 1.2 1 0 0 1 1 1 0 ABC-type cobalt transport system, permease component DUF3262 PF11660.8 EMC86978.1 - 0.11 12.9 3.6 0.13 12.7 2.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3262) LRR_6 PF13516.6 EMC86979.1 - 8.5e-32 106.5 2.4 0.012 15.6 0.0 10.9 11 0 0 11 11 11 9 Leucine Rich repeat LRR_4 PF12799.7 EMC86979.1 - 3.5e-17 62.2 0.0 0.01 16.2 0.0 6.7 3 2 5 8 8 8 6 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EMC86979.1 - 1.8e-16 59.8 4.4 1.8e-16 59.8 4.4 1.9 2 0 0 2 2 2 1 F-box-like LRR_1 PF00560.33 EMC86979.1 - 1.3e-12 46.4 6.6 2.4 9.0 0.0 10.0 10 1 0 10 10 10 2 Leucine Rich Repeat F-box PF00646.33 EMC86979.1 - 2.9e-12 46.2 2.0 2.9e-12 46.2 2.0 2.6 2 0 0 2 2 2 1 F-box domain DUF1699 PF08004.11 EMC86979.1 - 0.12 12.1 0.0 7.1 6.3 0.0 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF1699) TLE_N PF03920.15 EMC86980.1 - 6.1e-73 243.1 11.5 8.6e-73 242.6 11.5 1.2 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain WD40 PF00400.32 EMC86980.1 - 1.7e-16 60.3 18.7 0.016 16.1 0.8 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC86980.1 - 1.2e-07 32.0 0.0 0.13 12.5 0.0 4.3 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EMC86980.1 - 0.018 14.4 0.0 7.7 5.7 0.2 2.7 2 1 1 3 3 3 0 WD40-like domain HALZ PF02183.18 EMC86980.1 - 0.02 15.1 0.3 0.061 13.5 0.3 1.8 1 0 0 1 1 1 0 Homeobox associated leucine zipper Cytochrom_D1 PF02239.16 EMC86980.1 - 0.062 11.8 0.0 1.8 7.0 0.0 2.2 2 0 0 2 2 2 0 Cytochrome D1 heme domain Ribosomal_S18 PF01084.20 EMC86980.1 - 0.18 12.1 0.3 0.34 11.2 0.3 1.4 1 0 0 1 1 1 0 Ribosomal protein S18 Aminotran_5 PF00266.19 EMC86981.1 - 1.2e-63 215.3 0.0 1.4e-63 215.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V VWD PF00094.25 EMC86982.1 - 2e-92 307.6 20.3 2.7e-32 112.2 2.9 4.5 4 0 0 4 4 4 3 von Willebrand factor type D domain C8 PF08742.11 EMC86982.1 - 1.3e-46 156.9 51.6 7.2e-19 68.0 8.8 6.6 7 0 0 7 7 7 3 C8 domain Mucin2_WxxW PF13330.6 EMC86982.1 - 1.7e-28 99.3 4.0 4.6e-20 72.2 1.2 5.7 6 1 0 6 6 6 2 Mucin-2 protein WxxW repeating region TIL PF01826.17 EMC86982.1 - 1.2e-15 57.5 56.9 1.1e-08 35.2 17.6 12.8 10 4 3 13 13 13 4 Trypsin Inhibitor like cysteine rich domain VWC PF00093.18 EMC86982.1 - 0.00032 20.9 20.6 0.00082 19.6 7.4 13.6 7 5 5 12 12 12 2 von Willebrand factor type C domain HRI1 PF16815.5 EMC86982.1 - 1 9.0 6.5 0.15 11.7 2.4 1.6 2 0 0 2 2 2 0 Protein HRI1 PTB PF08416.13 EMC86984.1 - 2.3e-28 99.0 0.0 3.4e-28 98.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine-binding domain SH2 PF00017.24 EMC86984.1 - 1.4e-10 41.2 0.0 2.4e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 SH2 domain PID PF00640.23 EMC86984.1 - 0.0033 17.4 0.0 0.0051 16.8 0.0 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Endostatin PF06482.11 EMC86985.1 - 4.7e-65 220.1 0.0 5.5e-65 219.9 0.0 1.1 1 0 0 1 1 1 1 Collagenase NC10 and Endostatin DUF1554 PF07588.11 EMC86985.1 - 0.02 14.7 0.1 0.06 13.1 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1554) zf-C4 PF00105.18 EMC86987.1 - 2.5e-34 117.6 16.2 2.8e-34 117.4 16.2 1.0 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) EF-hand_1 PF00036.32 EMC86988.1 - 3.6e-17 60.6 8.8 8.1e-09 34.4 0.1 3.9 3 1 1 4 4 4 2 EF hand EF-hand_7 PF13499.6 EMC86988.1 - 3.3e-15 56.3 1.2 1.7e-13 50.8 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EMC86988.1 - 5.2e-15 54.0 3.1 1.8e-08 33.7 0.0 3.7 3 1 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 EMC86988.1 - 1.2e-13 49.8 5.6 6.3e-06 25.4 0.1 3.5 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EMC86988.1 - 1e-12 47.7 8.5 9.7e-10 38.1 0.4 4.2 2 2 2 4 4 4 2 EF-hand domain pair EF-hand_9 PF14658.6 EMC86988.1 - 0.00061 20.1 0.0 0.0023 18.2 0.0 1.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_4 PF12763.7 EMC86988.1 - 0.017 15.1 0.2 0.039 13.9 0.2 1.6 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EMC86988.1 - 0.028 14.7 0.2 0.13 12.6 0.0 2.1 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region 7tm_1 PF00001.21 EMC86989.1 - 6.8e-26 91.2 11.3 9.2e-26 90.7 11.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC86989.1 - 8.1e-26 91.4 11.1 9e-26 91.2 11.1 1.0 1 0 0 1 1 1 1 Olfactory receptor ANAPC3 PF12895.7 EMC86990.1 - 1.2e-28 99.1 16.0 1e-20 73.7 10.3 5.5 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 EMC86990.1 - 5.6e-24 82.3 17.6 0.00015 21.6 0.1 10.3 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_1 PF00515.28 EMC86990.1 - 8.3e-22 76.1 19.3 4.9e-08 32.5 0.2 8.6 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_12 PF13424.6 EMC86990.1 - 1.1e-16 60.9 15.7 4.5e-10 39.7 0.1 6.2 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMC86990.1 - 1.6e-16 59.0 7.3 0.0017 18.4 0.0 7.2 8 0 0 8 8 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 EMC86990.1 - 2.6e-13 48.9 5.9 1.5e-05 24.7 0.1 4.9 5 1 1 6 6 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 EMC86990.1 - 7.1e-12 44.8 1.8 0.00048 19.9 0.3 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 EMC86990.1 - 3.4e-09 37.1 5.7 0.33 11.5 3.6 4.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 EMC86990.1 - 4.5e-09 35.8 1.7 3.6e-06 26.5 0.0 4.7 5 1 0 5 5 4 1 TPR repeat TPR_17 PF13431.6 EMC86990.1 - 4.6e-09 36.0 0.1 1.2 9.7 0.0 6.1 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMC86990.1 - 2.3e-08 34.6 7.5 0.13 12.9 0.0 5.0 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 EMC86990.1 - 4.1e-07 30.1 0.3 0.074 13.2 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EMC86990.1 - 1.2e-05 25.7 11.9 3.8 8.6 0.0 7.4 5 3 3 8 8 7 1 Tetratricopeptide repeat SRP_TPR_like PF17004.5 EMC86990.1 - 0.0093 16.0 8.2 0.1 12.6 2.0 3.5 3 0 0 3 3 3 1 Putative TPR-like repeat TPR_3 PF07720.12 EMC86990.1 - 0.026 14.5 2.0 7.2 6.7 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMC86990.1 - 0.064 13.9 13.0 1.2 9.9 0.5 6.0 8 0 0 8 8 7 0 Tetratricopeptide repeat MIT PF04212.18 EMC86990.1 - 0.12 12.5 1.7 9.1 6.4 0.1 4.0 5 0 0 5 5 3 0 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.6 EMC86990.1 - 0.28 11.3 8.0 1.4 9.0 0.3 4.2 3 1 1 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat DUF5113 PF17140.4 EMC86990.1 - 3.4 7.4 11.0 3 7.6 0.0 4.4 4 1 1 5 5 5 0 Domain of unknown function (DUF5113) Laminin_G_1 PF00054.23 EMC86991.1 - 3.9e-29 101.5 0.0 1.4e-20 73.9 0.0 2.3 2 0 0 2 2 2 2 Laminin G domain Laminin_G_2 PF02210.24 EMC86991.1 - 3.9e-27 95.3 0.0 3.6e-14 53.4 0.0 2.2 2 0 0 2 2 2 2 Laminin G domain EGF_CA PF07645.15 EMC86991.1 - 2.1e-19 69.5 50.6 7.3e-08 32.5 8.1 4.9 3 1 1 4 4 4 4 Calcium-binding EGF domain cEGF PF12662.7 EMC86991.1 - 1.2e-12 47.5 31.9 4.4e-07 29.7 3.9 4.9 4 0 0 4 4 4 3 Complement Clr-like EGF-like EGF PF00008.27 EMC86991.1 - 1.1e-10 41.6 39.9 2.9e-06 27.5 5.6 4.9 4 0 0 4 4 4 3 EGF-like domain FXa_inhibition PF14670.6 EMC86991.1 - 2.8e-07 30.7 47.8 0.0086 16.3 9.1 4.6 3 1 1 4 4 4 3 Coagulation Factor Xa inhibitory site hEGF PF12661.7 EMC86991.1 - 1.6e-06 28.5 33.7 0.03 14.9 1.9 5.3 4 0 0 4 4 4 4 Human growth factor-like EGF EGF_3 PF12947.7 EMC86991.1 - 2.4e-05 24.4 39.3 0.00094 19.3 3.0 5.0 3 1 1 4 4 4 3 EGF domain FAM70 PF14967.6 EMC86992.1 - 8.3e-164 544.8 6.1 9.2e-164 544.7 6.1 1.0 1 0 0 1 1 1 1 FAM70 protein DUF4064 PF13273.6 EMC86992.1 - 4.8e-05 23.6 9.3 0.0021 18.3 5.6 2.6 2 1 0 2 2 2 2 Protein of unknown function (DUF4064) Phage_holin_3_2 PF04550.12 EMC86992.1 - 0.088 13.4 3.6 0.31 11.6 0.3 2.3 2 0 0 2 2 2 0 Phage holin family 2 DUF2407_C PF13373.6 EMC86992.1 - 0.85 9.8 2.0 6.9 6.8 1.1 2.2 2 0 0 2 2 2 0 DUF2407 C-terminal domain Na_K-ATPase PF00287.18 EMC86993.1 - 8.2e-100 333.6 0.4 9.4e-100 333.4 0.4 1.0 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain DP PF08781.10 EMC86994.1 - 1.6e-65 219.2 2.3 3.8e-65 217.9 2.3 1.6 1 0 0 1 1 1 1 Transcription factor DP E2F_TDP PF02319.20 EMC86994.1 - 1.3e-26 92.4 0.1 2.7e-26 91.4 0.1 1.5 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain alpha-hel2 PF14456.6 EMC86994.1 - 0.063 12.6 0.2 0.12 11.6 0.2 1.4 1 1 0 1 1 1 0 Alpha-helical domain 2 LMBR1 PF04791.16 EMC86994.1 - 0.19 10.6 1.0 0.23 10.3 1.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Na_H_Exchanger PF00999.21 EMC86995.1 - 1.2e-70 238.3 42.2 1.5e-70 237.9 42.2 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Glyco_hydro_36 PF17167.4 EMC86995.1 - 0.15 10.7 0.2 0.23 10.1 0.2 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase 36 superfamily, catalytic domain DUF16 PF01519.16 EMC86995.1 - 6.4 7.3 7.0 10 6.7 6.5 1.6 1 1 0 1 1 1 0 Protein of unknown function DUF16 Peptidase_S46 PF10459.9 EMC86995.1 - 8.9 4.8 9.0 12 4.3 9.0 1.1 1 0 0 1 1 1 0 Peptidase S46 Cullin_binding PF03556.15 EMC86996.1 - 3.2e-38 130.8 0.6 3.2e-38 130.8 0.6 2.0 2 1 0 2 2 2 1 Cullin binding UBA_4 PF14555.6 EMC86996.1 - 3.3e-09 36.4 2.7 4.3e-09 36.0 0.0 2.6 3 0 0 3 3 3 1 UBA-like domain ADP_ribosyl_GH PF03747.14 EMC86997.1 - 1.1e-54 186.2 0.2 1.2e-54 186.0 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase RabGAP-TBC PF00566.18 EMC87000.1 - 1.5e-57 194.7 0.1 2.1e-57 194.3 0.1 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Lamp PF01299.17 EMC87001.1 - 1.7e-57 193.4 13.0 7.8e-45 152.3 1.7 2.3 2 0 0 2 2 2 2 Lysosome-associated membrane glycoprotein (Lamp) ATP-synt_S1 PF05827.12 EMC87001.1 - 2.1e-07 30.9 2.3 1.6e-05 24.8 0.1 2.3 2 0 0 2 2 2 2 Vacuolar ATP synthase subunit S1 (ATP6S1) Cullin PF00888.22 EMC87002.1 - 1.6e-207 690.9 19.6 2.5e-207 690.3 19.6 1.3 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EMC87002.1 - 3e-24 84.8 0.3 1.2e-23 82.9 0.3 2.2 1 0 0 1 1 1 1 Cullin protein neddylation domain SecA_SW PF07516.13 EMC87002.1 - 0.0082 16.2 0.5 0.0082 16.2 0.5 3.2 2 1 1 3 3 3 1 SecA Wing and Scaffold domain OSCP PF00213.18 EMC87002.1 - 0.33 11.0 3.1 4.1 7.5 0.0 3.4 2 1 1 3 3 3 0 ATP synthase delta (OSCP) subunit PG_binding_4 PF12229.8 EMC87002.1 - 0.85 9.9 3.4 3.4 8.0 0.1 3.5 4 0 0 4 4 4 0 Putative peptidoglycan binding domain PCI PF01399.27 EMC87003.1 - 8e-18 64.9 1.9 1.9e-17 63.7 1.9 1.7 1 0 0 1 1 1 1 PCI domain Trypsin PF00089.26 EMC87004.1 - 2.3e-20 73.4 0.0 4.1e-20 72.6 0.0 1.4 1 0 0 1 1 1 1 Trypsin Gla PF00594.20 EMC87004.1 - 1.7e-13 50.5 7.5 3.5e-13 49.5 7.5 1.6 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.6 EMC87004.1 - 5e-10 39.5 30.1 7.1e-08 32.6 11.1 2.9 2 0 0 2 2 2 2 Coagulation Factor Xa inhibitory site EGF PF00008.27 EMC87004.1 - 3.7e-08 33.5 8.5 3.7e-08 33.5 8.5 3.5 4 1 0 4 4 4 2 EGF-like domain cEGF PF12662.7 EMC87004.1 - 6.6e-07 29.1 10.6 0.00011 22.1 0.7 3.1 2 0 0 2 2 2 2 Complement Clr-like EGF-like hEGF PF12661.7 EMC87004.1 - 3.6e-05 24.2 5.0 3.6e-05 24.2 5.0 3.5 3 0 0 3 3 3 2 Human growth factor-like EGF EGF_CA PF07645.15 EMC87004.1 - 0.0041 17.3 31.6 0.047 13.9 8.5 3.1 2 1 1 3 3 3 2 Calcium-binding EGF domain DUF1986 PF09342.11 EMC87004.1 - 0.0064 16.9 0.0 0.013 15.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) EGF_3 PF12947.7 EMC87004.1 - 0.38 11.0 21.1 0.2 11.9 7.0 3.0 2 1 0 2 2 2 0 EGF domain Plasmod_Pvs28 PF06247.11 EMC87004.1 - 0.46 10.8 15.9 3.9 7.9 4.5 2.7 2 0 0 2 2 2 0 Pvs28 EGF domain Trypsin PF00089.26 EMC87005.1 - 5.4e-59 199.7 0.0 6e-59 199.5 0.0 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 EMC87005.1 - 5.3e-06 26.8 0.0 8.8e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 EMC87005.1 - 0.0047 17.8 0.0 0.0062 17.4 0.0 1.3 1 1 0 1 1 1 1 Trypsin-like peptidase domain LepA_C PF06421.12 EMC87005.1 - 0.12 12.5 0.0 0.21 11.8 0.0 1.4 1 1 0 1 1 1 0 GTP-binding protein LepA C-terminus Trypsin PF00089.26 EMC87006.1 - 2.3e-71 240.1 0.1 3.7e-71 239.5 0.1 1.3 1 0 0 1 1 1 1 Trypsin Gla PF00594.20 EMC87006.1 - 4.3e-18 65.2 14.6 4.3e-18 65.2 14.6 2.2 1 1 1 2 2 2 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.6 EMC87006.1 - 8.9e-10 38.7 28.8 1.5e-09 38.0 4.9 3.0 3 0 0 3 3 3 2 Coagulation Factor Xa inhibitory site EGF PF00008.27 EMC87006.1 - 2.4e-07 30.9 19.5 1.6e-06 28.3 11.3 3.0 2 0 0 2 2 2 2 EGF-like domain DUF1986 PF09342.11 EMC87006.1 - 1.3e-06 28.7 0.0 3.1e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) cEGF PF12662.7 EMC87006.1 - 6e-06 26.1 16.3 0.0022 17.9 0.2 3.2 3 0 0 3 3 3 2 Complement Clr-like EGF-like Trypsin_2 PF13365.6 EMC87006.1 - 0.00011 23.1 0.0 0.00026 21.9 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain hEGF PF12661.7 EMC87006.1 - 0.00038 21.0 7.8 0.00038 21.0 7.8 4.0 2 1 0 2 2 2 1 Human growth factor-like EGF EGF_2 PF07974.13 EMC87006.1 - 3.3 8.2 29.4 0.6 10.5 16.0 3.3 2 0 0 2 2 2 0 EGF-like domain EGF_3 PF12947.7 EMC87006.1 - 3.4 7.9 24.2 7.4 6.9 6.5 3.0 2 0 0 2 2 2 0 EGF domain Trypsin PF00089.26 EMC87007.1 - 5.6e-64 216.0 0.2 8.8e-64 215.3 0.2 1.3 1 0 0 1 1 1 1 Trypsin Gla PF00594.20 EMC87007.1 - 1e-18 67.2 11.4 2e-18 66.3 9.2 2.3 1 1 1 2 2 2 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.6 EMC87007.1 - 1.1e-09 38.4 20.7 2e-09 37.6 6.2 2.9 1 1 1 2 2 2 2 Coagulation Factor Xa inhibitory site DUF1986 PF09342.11 EMC87007.1 - 3.7e-08 33.7 0.0 7.3e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) EGF PF00008.27 EMC87007.1 - 2.5e-07 30.9 8.0 2.5e-07 30.9 8.0 3.1 3 0 0 3 3 3 1 EGF-like domain hEGF PF12661.7 EMC87007.1 - 0.0003 21.3 5.3 0.0003 21.3 5.3 3.3 3 0 0 3 3 3 1 Human growth factor-like EGF Trypsin_2 PF13365.6 EMC87007.1 - 0.0033 18.3 0.1 0.0056 17.6 0.1 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain RhoGEF PF00621.20 EMC87008.1 - 3.7e-39 134.9 6.1 3.7e-39 134.9 6.1 3.5 3 1 0 3 3 3 1 RhoGEF domain PH PF00169.29 EMC87008.1 - 3.2e-09 37.2 0.1 8.4e-09 35.9 0.1 1.7 1 0 0 1 1 1 1 PH domain CRAL_TRIO_2 PF13716.6 EMC87008.1 - 7.3e-08 32.7 0.0 1.7e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain SH3_1 PF00018.28 EMC87008.1 - 5.9e-06 25.8 0.1 5.9e-06 25.8 0.1 2.2 3 0 0 3 3 3 1 SH3 domain SH3_9 PF14604.6 EMC87008.1 - 1.8e-05 24.5 1.2 7.7e-05 22.5 0.1 2.5 3 0 0 3 3 3 1 Variant SH3 domain Spectrin PF00435.21 EMC87008.1 - 7e-05 23.3 18.7 0.0082 16.6 0.0 5.2 4 2 1 5 5 5 2 Spectrin repeat SH3_2 PF07653.17 EMC87008.1 - 0.00011 21.8 0.0 0.00027 20.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH_10 PF15411.6 EMC87008.1 - 0.0035 17.6 0.3 0.012 15.9 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain PhoLip_ATPase_C PF16212.5 EMC87009.1 - 4.5e-80 269.0 29.9 4.5e-80 269.0 29.9 2.1 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EMC87009.1 - 6.3e-22 77.0 0.2 6.3e-22 77.0 0.2 2.1 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EMC87009.1 - 4.6e-11 43.4 0.2 4e-05 24.0 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EMC87009.1 - 3.1e-10 39.9 1.3 8.5e-10 38.4 0.0 2.4 2 1 1 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 EMC87009.1 - 3.6e-10 39.8 0.0 6.4e-09 35.8 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EMC87009.1 - 0.00071 19.4 0.0 0.083 12.6 0.0 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EMC87009.1 - 0.03 14.7 0.1 2.5 8.5 0.1 2.6 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase GCP_C_terminal PF04130.13 EMC87010.1 - 3.8e-83 279.5 10.8 3.8e-83 279.5 10.8 1.6 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EMC87010.1 - 7.2e-82 275.4 0.5 1.6e-81 274.3 0.5 1.6 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal PT PF04886.12 EMC87011.1 - 0.062 12.8 0.5 14 5.4 0.0 4.2 5 0 0 5 5 5 0 PT repeat HECT PF00632.25 EMC87012.1 - 4.8e-46 157.6 0.1 5.1e-46 157.5 0.1 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Phage_fiber_C PF06820.12 EMC87013.1 - 0.14 12.6 0.6 1.4e+02 2.9 0.0 4.4 1 1 5 6 6 6 0 Putative prophage tail fibre C-terminus Suf PF05843.14 EMC87015.1 - 0.00049 20.2 0.0 0.00057 20.0 0.0 1.1 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) LRR_8 PF13855.6 EMC87016.1 - 3.4e-32 110.0 17.4 7.2e-13 48.1 1.6 3.8 2 1 2 4 4 4 3 Leucine rich repeat I-set PF07679.16 EMC87016.1 - 2.6e-16 59.4 0.0 4.2e-16 58.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC87016.1 - 3e-14 53.4 0.0 5.8e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRR_5 PF13306.6 EMC87016.1 - 7e-12 45.4 2.0 5.9e-07 29.5 0.1 2.3 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 EMC87016.1 - 3.3e-11 43.2 19.6 0.0022 18.4 4.0 4.6 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) Ig_2 PF13895.6 EMC87016.1 - 1.8e-10 41.0 0.0 3.6e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC87016.1 - 5.4e-08 32.9 0.0 1e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain fn3 PF00041.21 EMC87016.1 - 1.1e-05 25.6 0.0 2.9e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III domain LRR_9 PF14580.6 EMC87016.1 - 4.1e-05 23.1 7.1 0.0026 17.3 1.2 2.5 1 1 1 2 2 2 2 Leucine-rich repeat V-set PF07686.17 EMC87016.1 - 0.003 17.7 0.0 2.1 8.6 0.0 2.4 1 1 1 2 2 2 2 Immunoglobulin V-set domain LRR_1 PF00560.33 EMC87016.1 - 0.0065 16.9 12.5 3.6 8.5 0.9 6.1 6 0 0 6 6 5 1 Leucine Rich Repeat DUF3139 PF11337.8 EMC87016.1 - 0.7 10.6 3.5 1.4 9.6 3.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) TPMT PF05724.11 EMC87017.1 - 6.6e-64 215.5 0.0 7.4e-64 215.4 0.0 1.0 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_25 PF13649.6 EMC87017.1 - 0.0055 17.4 0.0 0.073 13.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC87017.1 - 0.0082 16.8 0.0 0.031 14.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Amino_oxidase PF01593.24 EMC87018.1 - 2e-89 301.0 0.0 3.1e-89 300.4 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EMC87018.1 - 1.5e-11 44.3 0.1 3.8e-11 43.1 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain zf-CW PF07496.15 EMC87018.1 - 2.8e-10 40.1 1.8 2.8e-10 40.1 1.8 2.2 2 0 0 2 2 1 1 CW-type Zinc Finger Thi4 PF01946.17 EMC87018.1 - 1.3e-08 34.4 0.1 6.8e-08 32.0 0.1 2.0 2 0 0 2 2 2 1 Thi4 family SWIRM PF04433.17 EMC87018.1 - 4e-08 33.5 0.1 1e-07 32.2 0.1 1.7 1 0 0 1 1 1 1 SWIRM domain Pyr_redox_2 PF07992.14 EMC87018.1 - 1.1e-06 28.1 0.1 1.4e-05 24.5 0.1 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMC87018.1 - 1.4e-06 28.7 0.5 0.00011 22.7 0.2 3.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMC87018.1 - 2.9e-06 26.6 1.2 1.4e-05 24.3 1.4 1.8 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EMC87018.1 - 3.1e-06 26.1 1.5 2.6e-05 23.1 0.8 2.5 3 0 0 3 3 3 1 HI0933-like protein FAD_binding_3 PF01494.19 EMC87018.1 - 5.6e-06 25.8 0.3 6.8e-05 22.3 0.2 2.1 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.6 EMC87018.1 - 8.2e-06 25.3 3.4 0.00037 19.9 2.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMC87018.1 - 1.3e-05 25.0 0.0 7.3e-05 22.5 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EMC87018.1 - 6.4e-05 22.2 0.2 0.00011 21.3 0.2 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_oxidored PF12831.7 EMC87018.1 - 7e-05 22.4 0.3 0.00012 21.6 0.3 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.19 EMC87018.1 - 0.00026 20.4 0.0 0.00094 18.6 0.0 1.8 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GIDA PF01134.22 EMC87018.1 - 0.00061 19.0 0.8 0.001 18.3 0.8 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_9 PF13454.6 EMC87018.1 - 0.0033 17.4 0.6 0.1 12.6 0.2 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 EMC87018.1 - 0.0089 15.3 0.1 0.016 14.5 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain IlvN PF07991.12 EMC87018.1 - 0.013 15.1 0.3 0.022 14.3 0.3 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain zf-C3HC4 PF00097.25 EMC87018.1 - 0.1 12.5 4.0 0.39 10.6 4.0 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Shikimate_DH PF01488.20 EMC87018.1 - 0.12 12.4 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ThiF PF00899.21 EMC87018.1 - 0.13 11.6 0.0 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 ThiF family HCBP_related PF06594.11 EMC87018.1 - 0.14 12.1 0.1 0.35 10.8 0.1 1.7 1 0 0 1 1 1 0 Haemolysin-type calcium binding protein related domain NAD_binding_7 PF13241.6 EMC87018.1 - 0.23 11.9 1.9 0.74 10.3 0.2 2.2 2 0 0 2 2 2 0 Putative NAD(P)-binding Attractin PF08037.11 EMC87018.1 - 1.1 9.3 5.6 0.49 10.4 2.4 2.1 2 0 0 2 2 1 0 Attractin family zf-RING_2 PF13639.6 EMC87018.1 - 3.8 7.9 12.6 0.39 11.1 7.3 2.2 2 0 0 2 2 1 0 Ring finger domain DEK_C PF08766.11 EMC87019.1 - 3.3e-18 65.4 0.2 7.8e-18 64.1 0.2 1.7 1 0 0 1 1 1 1 DEK C terminal domain SAP PF02037.27 EMC87019.1 - 5.9e-06 25.9 1.6 1.6e-05 24.5 0.1 2.7 2 0 0 2 2 2 1 SAP domain Nucleolin_bd PF16725.5 EMC87019.1 - 0.038 13.6 0.1 0.15 11.8 0.1 2.0 2 0 0 2 2 2 0 Nucleolin binding domain DUF2052 PF09747.9 EMC87019.1 - 0.091 12.9 32.3 0.24 11.5 15.2 2.5 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) BSP_II PF05432.11 EMC87019.1 - 1.6 8.3 37.3 0.4 10.3 8.5 2.3 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) CDC45 PF02724.14 EMC87019.1 - 3.7 5.7 35.3 0.63 8.3 5.1 2.2 2 0 0 2 2 2 0 CDC45-like protein ORC6 PF05460.13 EMC87019.1 - 4.9 6.3 34.7 0.076 12.3 23.4 2.1 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) Apt1 PF10351.9 EMC87019.1 - 6.2 5.6 30.5 0.28 10.0 18.9 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain Hid1 PF12722.7 EMC87019.1 - 8.8 4.3 25.7 0.53 8.3 13.0 2.1 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein MDM1 PF15501.6 EMC87019.1 - 9 5.3 45.5 0.19 10.9 27.8 2.1 2 0 0 2 2 2 0 Nuclear protein MDM1 IBR PF01485.21 EMC87020.1 - 6.4e-19 67.9 23.7 7e-14 51.8 8.0 4.7 4 1 1 5 5 5 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 EMC87020.1 - 0.031 14.6 13.7 0.031 14.6 13.7 5.1 4 1 0 4 4 4 0 Ring finger domain HLH PF00010.26 EMC87021.1 - 3.6e-06 26.8 0.0 5.2e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain MBOAT PF03062.19 EMC87022.1 - 9.1e-30 104.2 11.9 9.1e-30 104.2 11.9 2.1 1 1 1 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family E2F_CC-MB PF16421.5 EMC87023.1 - 1.4e-32 111.9 0.3 2.5e-32 111.1 0.3 1.4 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.20 EMC87023.1 - 2.3e-25 88.4 1.0 3.7e-25 87.8 0.2 1.8 2 0 0 2 2 2 1 E2F/DP family winged-helix DNA-binding domain UPF0004 PF00919.20 EMC87024.1 - 2.8e-21 75.4 0.0 5.8e-21 74.4 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 Radical_SAM PF04055.21 EMC87024.1 - 1.5e-19 71.0 0.1 4e-19 69.6 0.1 1.7 2 0 0 2 2 2 1 Radical SAM superfamily TRAM PF01938.20 EMC87024.1 - 1.5e-05 24.9 0.0 3.2e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 TRAM domain Styelin PF17562.2 EMC87024.1 - 0.021 15.2 0.0 0.07 13.5 0.0 2.0 1 0 0 1 1 1 0 Styelin Hormone_1 PF00103.20 EMC87026.1 - 3.2e-72 242.8 0.0 3.6e-72 242.6 0.0 1.0 1 0 0 1 1 1 1 Somatotropin hormone family KIAA1430 PF13879.6 EMC87026.1 - 0.15 12.8 0.0 1.3 9.8 0.0 2.1 2 0 0 2 2 2 0 KIAA1430 homologue Neurensin PF14927.6 EMC87027.1 - 2.6e-51 172.8 0.1 3.3e-51 172.5 0.1 1.1 1 0 0 1 1 1 1 Neurensin DUF624 PF04854.14 EMC87027.1 - 0.16 12.1 1.1 0.62 10.2 0.6 2.0 1 1 1 2 2 2 0 Protein of unknown function, DUF624 CrgA PF06781.12 EMC87027.1 - 0.32 11.1 0.9 0.95 9.6 0.8 1.9 1 1 0 1 1 1 0 Cell division protein CrgA DCX PF03607.17 EMC87028.1 - 3.3e-40 136.0 0.0 2.2e-20 72.5 0.0 2.4 2 0 0 2 2 2 2 Doublecortin CcmB PF03379.13 EMC87029.1 - 0.047 13.2 0.1 0.083 12.4 0.1 1.4 1 0 0 1 1 1 0 CcmB protein FG-GAP PF01839.23 EMC87030.1 - 2.2e-27 94.8 39.8 1.6e-09 37.7 1.4 6.2 6 1 0 6 6 6 4 FG-GAP repeat Zn_dep_PLPC PF00882.18 EMC87030.1 - 9.3e-25 87.7 2.6 2e-24 86.5 2.6 1.6 1 0 0 1 1 1 1 Zinc dependent phospholipase C VCBS PF13517.6 EMC87030.1 - 5.5e-13 49.3 14.1 1.1e-06 29.1 1.0 5.0 3 1 2 5 5 5 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TcdB_toxin_midN PF12256.8 EMC87030.1 - 0.0055 16.1 0.7 0.99 8.7 0.1 3.5 2 1 1 3 3 3 1 Insecticide toxin TcdB middle/N-terminal region Hfx_Cass5 PF18287.1 EMC87030.1 - 0.15 12.3 0.0 0.4 10.9 0.0 1.7 1 0 0 1 1 1 0 Integron Cassette Protein Hfx_Cass5 Aldedh PF00171.22 EMC87031.1 - 3.3e-150 500.6 1.3 3.6e-150 500.5 1.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Y_Y_Y PF07495.13 EMC87032.1 - 2.6e-17 62.5 0.0 0.0013 18.7 0.0 5.4 5 0 0 5 5 5 3 Y_Y_Y domain REJ PF02010.15 EMC87032.1 - 7.3e-11 41.5 1.2 0.00011 21.1 0.1 4.8 1 1 2 3 3 3 3 REJ domain PKD PF00801.20 EMC87032.1 - 2.6e-10 40.0 6.5 0.087 12.7 0.0 5.9 5 1 0 5 5 5 2 PKD domain Big_9 PF17963.1 EMC87032.1 - 8.4e-10 39.3 15.2 0.011 16.4 0.1 4.8 4 1 0 4 4 4 3 Bacterial Ig domain DUF4625 PF15418.6 EMC87032.1 - 2.5e-07 31.0 0.0 3.8 7.8 0.0 4.4 4 0 0 4 4 4 2 Domain of unknown function (DUF4625) He_PIG PF05345.12 EMC87032.1 - 9.9e-07 28.9 2.8 7.7 6.8 0.1 5.0 5 0 0 5 5 5 1 Putative Ig domain DUF5013 PF16405.5 EMC87032.1 - 7.4e-06 26.3 0.1 0.16 12.2 0.0 4.5 4 1 1 5 5 5 1 Domain of unknown function (DUF5013) Wzt_C PF14524.6 EMC87032.1 - 1.4e-05 25.2 0.0 1.5 8.9 0.0 4.8 5 0 0 5 5 5 1 Wzt C-terminal domain DUF4998 PF16389.5 EMC87032.1 - 0.00053 19.6 2.7 4.8 6.7 0.0 4.9 5 0 0 5 5 5 1 Domain of unknown function FixG_C PF11614.8 EMC87032.1 - 0.005 17.1 2.8 13 6.0 0.1 4.0 4 0 0 4 4 4 0 IG-like fold at C-terminal of FixG, putative oxidoreductase MBG PF17883.1 EMC87032.1 - 0.01 16.4 2.4 4 8.1 0.2 3.2 3 1 0 3 3 2 0 MBG domain DUF5011 PF16403.5 EMC87032.1 - 0.012 15.7 2.0 14 5.9 0.1 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF5011) PA14 PF07691.12 EMC87032.1 - 0.015 15.1 0.6 2.1 8.1 0.0 3.9 5 0 0 5 5 5 0 PA14 domain Cadherin PF00028.17 EMC87032.1 - 0.018 15.5 2.2 12 6.4 0.3 4.1 3 1 0 3 3 3 0 Cadherin domain Shisa PF13908.6 EMC87032.1 - 0.019 15.2 0.2 0.037 14.3 0.2 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Cadherin_5 PF17892.1 EMC87032.1 - 0.024 14.6 4.8 21 5.2 0.1 4.7 5 0 0 5 5 4 0 Cadherin-like domain DUF4388 PF14332.6 EMC87032.1 - 0.057 13.7 0.0 0.7 10.2 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4388) DUF1180 PF06679.12 EMC87032.1 - 0.066 13.6 0.0 0.22 11.9 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Cadherin-like PF12733.7 EMC87032.1 - 0.61 10.6 3.0 8.4 7.0 0.0 3.7 4 0 0 4 4 4 0 Cadherin-like beta sandwich domain Synaphin PF05835.12 EMC87032.1 - 0.7 10.2 3.1 1.3 9.3 3.1 1.3 1 0 0 1 1 1 0 Synaphin protein Invasin_D3 PF09134.10 EMC87032.1 - 0.89 9.9 5.2 22 5.4 0.4 4.3 2 1 2 4 4 4 0 Invasin, domain 3 Sec7 PF01369.20 EMC87033.1 - 1.9e-75 252.6 0.6 4.4e-75 251.4 0.6 1.7 1 0 0 1 1 1 1 Sec7 domain DUF1981 PF09324.10 EMC87033.1 - 5.6e-36 122.3 0.2 5.6e-36 122.3 0.2 4.8 8 0 0 8 8 8 1 Domain of unknown function (DUF1981) Sec7_N PF12783.7 EMC87033.1 - 1.2e-12 48.1 0.5 1.2e-12 48.1 0.5 3.2 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal ANAPC4_WD40 PF12894.7 EMC87033.1 - 0.12 12.7 0.0 1.7 9.0 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain JAB PF01398.21 EMC87035.1 - 3.4e-34 117.4 0.0 4.9e-34 116.8 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 EMC87035.1 - 1.7e-11 44.9 0.3 2.8e-11 44.2 0.3 1.4 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 EMC87035.1 - 0.0001 22.0 0.0 0.00015 21.5 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 EMC87035.1 - 0.0039 17.3 0.0 0.0054 16.8 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) LRR_4 PF12799.7 EMC87036.1 - 1.5e-19 69.8 27.2 1.7e-06 28.3 3.5 5.0 3 2 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC87036.1 - 5.8e-18 65.0 12.5 3.9e-10 39.5 1.6 2.9 2 1 0 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 EMC87036.1 - 7.6e-15 54.4 22.0 9.7e-06 25.3 2.8 4.9 3 1 2 5 5 5 4 Leucine rich repeat LRR_1 PF00560.33 EMC87036.1 - 5.9e-08 32.2 23.7 2.6 8.9 0.1 7.5 7 0 0 7 7 7 4 Leucine Rich Repeat zf-ISL3 PF14690.6 EMC87036.1 - 0.14 12.8 0.1 0.75 10.5 0.0 2.3 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 LRR_6 PF13516.6 EMC87036.1 - 0.21 11.7 17.9 26 5.2 0.3 7.3 7 1 1 8 8 8 0 Leucine Rich repeat FNIP PF05725.12 EMC87036.1 - 3.2 8.0 10.0 6 7.1 5.8 3.0 2 1 0 2 2 2 0 FNIP Repeat HLH PF00010.26 EMC87037.1 - 7e-13 48.3 0.0 8.3e-13 48.1 0.0 1.1 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain MCM_lid PF17855.1 EMC87038.1 - 3.2e-10 40.3 0.2 6e-10 39.4 0.2 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain MCM PF00493.23 EMC87038.1 - 0.00067 18.8 0.0 0.0014 17.7 0.0 1.5 1 0 0 1 1 1 1 MCM P-loop domain Pkinase PF00069.25 EMC87039.1 - 4.5e-67 226.2 0.0 5.7e-67 225.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87039.1 - 2.3e-34 118.8 0.0 3.3e-34 118.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PX PF00787.24 EMC87039.1 - 1.8e-20 73.0 0.2 4.5e-20 71.7 0.2 1.7 1 0 0 1 1 1 1 PX domain Pkinase_C PF00433.24 EMC87039.1 - 1.3e-05 25.8 1.7 0.00074 20.2 0.1 2.6 2 1 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.6 EMC87039.1 - 5.3e-05 22.7 0.0 0.00017 21.0 0.0 1.7 1 1 0 1 1 1 1 Kinase-like FTA2 PF13095.6 EMC87039.1 - 0.0025 17.5 0.1 0.38 10.3 0.1 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EMC87039.1 - 0.0097 15.3 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EMC87039.1 - 0.1 11.5 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Cmyb_C PF09316.10 EMC87040.1 - 2e-79 265.0 2.8 4.5e-79 263.8 2.8 1.7 1 0 0 1 1 1 1 C-myb, C-terminal Myb_DNA-binding PF00249.31 EMC87040.1 - 4.2e-52 174.1 17.4 4e-18 65.3 2.0 3.7 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EMC87040.1 - 1.6e-39 133.9 17.7 6.8e-18 64.7 2.2 3.9 1 1 2 3 3 3 3 Myb-like DNA-binding domain LMSTEN PF07988.12 EMC87040.1 - 6.8e-25 86.3 0.5 1.5e-24 85.2 0.5 1.6 1 0 0 1 1 1 1 LMSTEN motif Myb_DNA-bind_7 PF15963.5 EMC87040.1 - 8.5e-08 32.0 5.3 0.00036 20.4 0.1 3.9 1 1 2 3 3 3 2 Myb DNA-binding like SLIDE PF09111.10 EMC87040.1 - 9.4e-06 25.6 5.5 1.3 9.1 0.2 4.4 2 1 2 4 4 4 3 SLIDE SANT_DAMP1_like PF16282.5 EMC87040.1 - 0.028 14.6 7.1 1.3 9.3 0.0 3.8 2 1 2 4 4 4 0 SANT/Myb-like domain of DAMP1 Sigma70_r4_2 PF08281.12 EMC87040.1 - 0.029 14.0 0.0 0.67 9.7 0.0 2.4 2 0 0 2 2 2 0 Sigma-70, region 4 Rap1_C PF11626.8 EMC87040.1 - 0.27 11.4 10.2 41 4.4 6.3 4.2 2 1 1 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Spore_III_AB PF09548.10 EMC87040.1 - 0.83 9.8 3.5 1.6 8.8 0.1 2.8 2 1 1 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) Fe-ADH PF00465.19 EMC87042.1 - 5.2e-105 351.2 0.0 6.2e-105 351.0 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EMC87042.1 - 3.5e-15 56.4 0.0 7e-11 42.3 0.0 2.2 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Peripla_BP_6 PF13458.6 EMC87042.1 - 0.017 14.8 0.0 0.029 14.0 0.0 1.3 1 0 0 1 1 1 0 Periplasmic binding protein CRF PF00473.17 EMC87043.1 - 2.3e-16 59.6 1.0 2.3e-16 59.6 1.0 1.6 2 0 0 2 2 2 1 Corticotropin-releasing factor family zf-RING_UBOX PF13445.6 EMC87044.1 - 2.5e-10 40.2 4.0 8.1e-10 38.6 4.0 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EMC87044.1 - 2.9e-08 33.4 2.3 2.9e-08 33.4 2.3 2.6 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC87044.1 - 7.3e-08 32.2 3.6 7.3e-08 32.2 3.6 2.6 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC87044.1 - 5.3e-07 29.9 4.5 5.3e-07 29.9 4.5 3.1 3 1 0 3 3 1 1 Ring finger domain zf-RING_5 PF14634.6 EMC87044.1 - 1.4e-06 28.2 4.6 1.4e-06 28.2 4.6 2.8 3 0 0 3 3 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EMC87044.1 - 1.2e-05 25.0 7.1 1.2e-05 25.0 7.1 3.2 3 1 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EMC87044.1 - 3.1e-05 23.7 0.4 3.1e-05 23.7 0.4 2.1 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 EMC87044.1 - 3.5e-05 23.9 7.2 3.5e-05 23.9 7.2 3.2 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.24 EMC87044.1 - 4.7e-05 23.5 10.4 4.7e-05 23.5 10.4 3.5 4 0 0 4 4 4 1 B-box zinc finger EzrA PF06160.12 EMC87044.1 - 0.011 13.9 11.4 0.018 13.2 11.4 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA AGOG PF09171.10 EMC87044.1 - 0.11 11.8 1.1 0.3 10.4 0.1 2.0 1 1 1 2 2 2 0 N-glycosylase/DNA lyase zf-RING_11 PF17123.5 EMC87044.1 - 2.3 8.0 9.9 1.9 8.3 6.2 2.6 2 0 0 2 2 2 0 RING-like zinc finger DnaJ PF00226.31 EMC87045.1 - 3.7e-26 91.0 2.7 6.3e-26 90.3 2.7 1.4 1 0 0 1 1 1 1 DnaJ domain EMP70 PF02990.16 EMC87045.1 - 0.12 11.0 0.1 0.14 10.8 0.1 1.1 1 0 0 1 1 1 0 Endomembrane protein 70 Corona_S2 PF01601.16 EMC87045.1 - 0.14 10.7 3.7 0.17 10.4 3.7 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Mito_fiss_reg PF05308.11 EMC87046.1 - 8e-81 271.8 3.2 1.2e-80 271.2 3.2 1.2 1 0 0 1 1 1 1 Mitochondrial fission regulator FlxA PF14282.6 EMC87046.1 - 0.02 14.9 1.2 0.052 13.5 1.2 1.6 1 0 0 1 1 1 0 FlxA-like protein Totivirus_coat PF05518.11 EMC87046.1 - 0.48 8.4 4.5 0.62 8.0 4.5 1.1 1 0 0 1 1 1 0 Totivirus coat protein Arm PF00514.23 EMC87047.1 - 2.7e-05 24.0 0.0 6e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Armadillo/beta-catenin-like repeat HMA PF00403.26 EMC87047.1 - 0.0017 18.8 0.1 0.0032 17.9 0.1 1.5 1 0 0 1 1 1 1 Heavy-metal-associated domain p450 PF00067.22 EMC87048.1 - 1.3e-51 175.9 0.3 1.6e-51 175.5 0.3 1.1 1 0 0 1 1 1 1 Cytochrome P450 YTH PF04146.15 EMC87049.1 - 1.2e-39 135.9 0.5 1.2e-39 135.9 0.5 2.3 2 1 0 2 2 2 1 YT521-B-like domain TFIIA PF03153.13 EMC87049.1 - 0.017 15.2 11.3 0.027 14.5 11.3 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CRAL_TRIO PF00650.20 EMC87050.1 - 1.6e-31 109.2 0.0 2e-31 108.8 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain DUF5007 PF16398.5 EMC87050.1 - 0.084 12.5 0.1 0.17 11.5 0.0 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5007) Peptidase_C26 PF07722.13 EMC87051.1 - 2.7e-19 69.8 0.0 1.3e-18 67.6 0.0 2.0 1 1 0 1 1 1 1 Peptidase C26 GATase PF00117.28 EMC87051.1 - 5.1e-09 36.2 0.0 8.2e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NKAIN PF05640.14 EMC87052.1 - 1.2e-78 263.1 11.2 1.4e-78 262.9 11.2 1.0 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein DUF1003 PF06210.11 EMC87052.1 - 0.38 10.9 4.7 0.093 12.8 1.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) CRAL_TRIO PF00650.20 EMC87053.1 - 3.7e-34 117.7 0.0 5.8e-34 117.1 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EMC87053.1 - 3.1e-08 33.9 0.0 4.9e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EMC87053.1 - 1.4e-06 28.4 0.1 2.7e-06 27.4 0.1 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain SNF2_N PF00176.23 EMC87054.1 - 5.6e-63 212.8 0.3 1e-62 211.9 0.3 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain BRK PF07533.16 EMC87054.1 - 1.8e-37 126.7 2.8 2e-18 65.8 0.2 2.6 2 0 0 2 2 2 2 BRK domain Chromo PF00385.24 EMC87054.1 - 1.1e-24 86.1 9.2 4.7e-13 48.8 0.5 2.7 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 EMC87054.1 - 6.5e-17 61.9 0.0 1.7e-16 60.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC87054.1 - 6.7e-07 29.5 0.0 2.4e-06 27.7 0.0 2.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CHDCT2 PF08074.11 EMC87054.1 - 2.9e-05 24.3 2.6 1.1 9.5 0.0 4.6 4 0 0 4 4 4 2 CHDCT2 (NUC038) domain Myb_DNA-bind_7 PF15963.5 EMC87054.1 - 0.013 15.4 0.2 0.078 12.9 0.2 2.4 1 0 0 1 1 1 0 Myb DNA-binding like Ras PF00071.22 EMC87055.1 - 5.5e-59 198.4 0.1 6.8e-59 198.1 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC87055.1 - 1.2e-29 103.0 0.1 3.7e-29 101.4 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC87055.1 - 6.9e-12 45.2 0.0 8.5e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC87055.1 - 0.00097 18.7 0.0 0.0012 18.4 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EMC87055.1 - 0.004 16.5 0.0 0.0052 16.2 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMC87055.1 - 0.017 15.2 0.0 0.028 14.5 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase Carb_anhydrase PF00194.21 EMC87056.1 - 2.7e-79 266.3 0.0 3e-79 266.1 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase HMG_box PF00505.19 EMC87057.1 - 9.6e-18 64.4 0.4 2.2e-17 63.2 0.4 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC87057.1 - 9.1e-12 45.4 0.6 1.9e-11 44.4 0.6 1.5 1 0 0 1 1 1 1 HMG-box domain YABBY PF04690.13 EMC87057.1 - 0.02 15.4 1.2 0.031 14.9 0.4 1.9 1 1 0 1 1 1 0 YABBY protein Mitofilin PF09731.9 EMC87057.1 - 0.099 11.5 5.2 0.13 11.1 5.2 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Beach PF02138.18 EMC87058.1 - 3.8e-115 384.0 0.0 5.9e-115 383.4 0.0 1.3 1 0 0 1 1 1 1 Beige/BEACH domain GRAM PF02893.20 EMC87058.1 - 4.4e-18 65.2 0.1 4.1e-17 62.1 0.1 2.5 2 0 0 2 2 2 1 GRAM domain WD40 PF00400.32 EMC87058.1 - 1e-13 51.5 17.4 0.12 13.2 0.0 7.8 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC87058.1 - 7.6e-08 32.6 5.5 0.0092 16.3 0.1 4.9 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PH_BEACH PF14844.6 EMC87058.1 - 4.9e-06 26.6 0.0 0.41 10.8 0.0 3.8 2 1 0 2 2 2 2 PH domain associated with Beige/BEACH NABP PF07990.12 EMC87058.1 - 0.16 11.5 0.1 0.24 10.9 0.1 1.2 1 0 0 1 1 1 0 Nucleic acid binding protein NABP Hira PF07569.11 EMC87058.1 - 0.45 10.2 2.6 2.1 8.0 0.3 2.7 3 0 0 3 3 3 0 TUP1-like enhancer of split PDZ_6 PF17820.1 EMC87059.1 - 7e-23 80.2 0.4 3.3e-14 52.5 0.0 2.3 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 EMC87059.1 - 4.8e-21 74.9 2.2 4.8e-13 49.3 0.1 3.0 3 0 0 3 3 3 2 PDZ domain PDZ_2 PF13180.6 EMC87059.1 - 2.7e-12 46.8 0.2 2.4e-07 31.0 0.0 2.5 2 0 0 2 2 2 2 PDZ domain p450 PF00067.22 EMC87060.1 - 1.2e-78 264.9 1.3 1.5e-78 264.6 1.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 SEP PF08059.13 EMC87061.1 - 3.6e-28 97.9 1.6 7.6e-28 96.9 0.1 2.3 2 1 1 3 3 3 1 SEP domain UBX PF00789.20 EMC87061.1 - 2.2e-18 66.2 0.4 4e-18 65.4 0.4 1.4 1 0 0 1 1 1 1 UBX domain Phage_capsid PF05065.13 EMC87061.1 - 0.098 11.9 0.0 0.22 10.8 0.0 1.5 2 0 0 2 2 2 0 Phage capsid family FAM110_N PF14161.6 EMC87062.1 - 2.1e-44 150.1 3.9 5.1e-44 148.9 3.9 1.7 1 0 0 1 1 1 1 Centrosome-associated N terminus FAM110_C PF14160.6 EMC87062.1 - 2.3e-33 115.6 0.3 2.3e-33 115.6 0.3 2.1 2 1 0 2 2 2 1 Centrosome-associated C terminus adh_short PF00106.25 EMC87063.1 - 9.7e-49 165.5 0.3 1.2e-48 165.2 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC87063.1 - 6.4e-34 117.5 0.0 8e-34 117.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC87063.1 - 5.4e-10 39.5 0.2 7.4e-10 39.0 0.2 1.1 1 0 0 1 1 1 1 KR domain Methyltransf_25 PF13649.6 EMC87063.1 - 0.016 15.9 0.0 0.029 15.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain 3HCDH_N PF02737.18 EMC87063.1 - 0.051 13.5 0.1 0.081 12.8 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 EMC87063.1 - 0.056 12.8 0.0 0.087 12.2 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EMC87063.1 - 0.096 12.0 0.3 0.14 11.5 0.3 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ApbA PF02558.16 EMC87063.1 - 0.15 11.7 0.1 0.26 10.9 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA CEP1-DNA_bind PF09287.10 EMC87064.1 - 0.00066 19.4 0.1 0.00081 19.1 0.1 1.1 1 0 0 1 1 1 1 CEP-1, DNA binding MTCP1 PF08991.10 EMC87064.1 - 0.0011 19.1 0.7 0.0013 18.9 0.7 1.2 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type DUF761 PF05553.11 EMC87064.1 - 0.073 12.6 0.2 0.17 11.5 0.2 1.6 1 0 0 1 1 1 0 Cotton fibre expressed protein CHCH PF06747.13 EMC87064.1 - 0.24 11.6 5.4 0.36 11.0 5.4 1.3 1 0 0 1 1 1 0 CHCH domain CysG_dimeriser PF10414.9 EMC87064.1 - 0.3 10.8 2.2 0.39 10.5 0.0 2.1 2 1 1 3 3 3 0 Sirohaem synthase dimerisation region zf-H2C2_2 PF13465.6 EMC87065.1 - 2.7e-25 87.6 56.2 3.7e-05 23.9 1.0 8.5 8 0 0 8 8 8 8 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC87065.1 - 2e-24 84.1 58.0 0.00058 20.5 1.1 7.5 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC87065.1 - 5.4e-23 80.1 64.8 6.1e-05 23.3 1.4 7.6 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EMC87065.1 - 1.6e-05 24.7 51.8 0.023 14.7 0.6 7.3 7 0 0 7 7 7 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC87065.1 - 2.3e-05 24.6 45.1 0.032 14.5 1.1 7.1 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC87065.1 - 0.00027 21.2 26.9 0.29 11.6 0.7 5.8 5 0 0 5 5 5 4 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 EMC87065.1 - 0.0021 18.3 30.4 0.038 14.3 10.3 4.3 1 1 2 3 3 3 2 C2H2-type zinc ribbon Acyltransf_C PF16076.5 EMC87065.1 - 0.0052 16.8 3.8 0.92 9.6 0.7 2.7 2 0 0 2 2 2 2 Acyltransferase C-terminus zf-C2H2_11 PF16622.5 EMC87065.1 - 0.035 13.9 0.0 0.035 13.9 0.0 6.6 8 0 0 8 8 8 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 EMC87065.1 - 0.1 13.0 40.8 1.1 9.6 1.4 5.5 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_9 PF16293.5 EMC87065.1 - 2 8.3 8.7 1.2e+02 2.6 0.0 5.1 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) zf-LITAF-like PF10601.9 EMC87065.1 - 7.3 6.9 14.9 0.25 11.6 2.4 3.7 3 1 0 3 3 3 0 LITAF-like zinc ribbon domain zf-Di19 PF05605.12 EMC87065.1 - 9.3 6.6 37.2 0.8 10.0 1.1 5.0 1 1 6 7 7 7 0 Drought induced 19 protein (Di19), zinc-binding Pkinase PF00069.25 EMC87066.1 - 1.7e-46 158.7 0.0 2.3e-46 158.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87066.1 - 3.8e-41 141.1 0.0 4.6e-41 140.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC87066.1 - 0.0047 16.3 0.0 0.01 15.2 0.0 1.4 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EMC87066.1 - 0.02 13.7 0.0 0.032 13.0 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Ribosomal_S10 PF00338.22 EMC87067.1 - 4.7e-31 106.9 0.3 5.6e-31 106.7 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Pkinase_Tyr PF07714.17 EMC87068.1 - 8.5e-97 323.5 0.0 1.1e-96 323.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC87068.1 - 9.1e-49 166.2 0.0 1.3e-48 165.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 EMC87068.1 - 9.1e-24 83.4 0.0 1.8e-23 82.4 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 EMC87068.1 - 1.6e-16 59.7 0.1 3.5e-16 58.5 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC87068.1 - 8.2e-09 35.0 0.5 2.7e-08 33.4 0.1 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 EMC87068.1 - 1.4e-08 34.5 0.0 4.1e-08 33.0 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 EMC87068.1 - 0.0053 17.0 0.1 0.011 16.0 0.1 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain Haspin_kinase PF12330.8 EMC87068.1 - 0.016 14.2 0.1 0.033 13.2 0.1 1.5 1 1 0 1 1 1 0 Haspin like kinase domain Acyltransferase PF01553.21 EMC87069.1 - 2.5e-07 30.4 0.0 9.3e-07 28.5 0.0 1.9 1 1 0 1 1 1 1 Acyltransferase DAGAT PF03982.13 EMC87069.1 - 0.00012 21.1 0.1 0.00025 20.0 0.0 1.5 2 0 0 2 2 2 1 Diacylglycerol acyltransferase XK-related PF09815.9 EMC87070.1 - 1.1e-105 353.4 26.5 1.3e-105 353.2 26.5 1.0 1 0 0 1 1 1 1 XK-related protein PLAT PF01477.23 EMC87072.1 - 1.1e-18 67.9 0.1 2.1e-18 67.0 0.0 1.5 1 1 1 2 2 2 1 PLAT/LH2 domain DCX PF03607.17 EMC87073.1 - 2.9e-37 126.6 0.0 1.2e-20 73.3 0.0 2.6 2 0 0 2 2 2 2 Doublecortin DUF4065 PF13274.6 EMC87073.1 - 2.3 9.1 5.7 1.7 9.6 1.2 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4065) HMG_box PF00505.19 EMC87074.1 - 2.7e-11 43.7 0.0 3.9e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC87074.1 - 0.016 15.8 0.0 0.024 15.2 0.0 1.3 1 0 0 1 1 1 0 HMG-box domain Ribosomal_L27A PF00828.19 EMC87075.1 - 5.9e-28 98.1 0.0 8.7e-28 97.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Abhydrolase_2 PF02230.16 EMC87076.1 - 8.1e-75 251.3 0.0 9.1e-75 251.2 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EMC87076.1 - 3.1e-07 29.9 0.0 0.0014 17.9 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EMC87076.1 - 3.3e-06 27.1 0.0 4.4e-05 23.4 0.0 2.0 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 EMC87076.1 - 0.00078 19.2 0.0 0.0019 17.9 0.0 1.4 1 1 1 2 2 2 1 alpha/beta hydrolase fold Cutinase PF01083.22 EMC87076.1 - 0.001 19.0 0.0 0.0018 18.3 0.0 1.3 1 0 0 1 1 1 1 Cutinase DLH PF01738.18 EMC87076.1 - 0.0011 18.5 0.0 0.0015 18.1 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EMC87076.1 - 0.0019 17.7 0.0 1.7 8.1 0.0 2.1 1 1 1 2 2 2 2 Prolyl oligopeptidase family DUF2974 PF11187.8 EMC87076.1 - 0.0045 16.6 0.0 0.0064 16.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) FSH1 PF03959.13 EMC87076.1 - 0.0048 16.6 0.0 0.0064 16.2 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 EMC87076.1 - 0.023 15.3 0.0 0.023 15.3 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Esterase PF00756.20 EMC87076.1 - 0.063 12.9 0.0 0.074 12.7 0.0 1.2 1 0 0 1 1 1 0 Putative esterase DUF2920 PF11144.8 EMC87076.1 - 0.089 11.9 0.0 0.25 10.5 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2920) Lipase_3 PF01764.25 EMC87076.1 - 0.11 12.4 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) AXE1 PF05448.12 EMC87076.1 - 0.18 10.5 0.0 0.27 9.9 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) RGS PF00615.19 EMC87077.1 - 6.8e-35 119.9 1.3 8.9e-35 119.5 1.3 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS12_usC PF16612.5 EMC87077.1 - 0.044 14.2 0.2 0.075 13.5 0.2 1.3 1 0 0 1 1 1 0 C-terminal unstructured region of RGS12 V-ATPase_H_N PF03224.14 EMC87078.1 - 1.2e-104 350.0 6.9 1.2e-104 350.0 6.9 2.1 2 1 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 EMC87078.1 - 5.4e-47 158.7 0.3 5.4e-47 158.7 0.3 2.6 3 0 0 3 3 3 1 V-ATPase subunit H Arm PF00514.23 EMC87078.1 - 2.2e-08 33.8 0.2 0.00046 20.1 0.0 4.9 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 EMC87078.1 - 0.00034 20.1 0.6 0.0017 17.9 0.0 2.3 3 0 0 3 3 3 1 Armadillo-like HEAT_2 PF13646.6 EMC87078.1 - 0.0023 18.3 0.1 1.1 9.7 0.0 2.9 2 1 0 2 2 2 1 HEAT repeats Adaptin_N PF01602.20 EMC87078.1 - 0.008 14.8 5.0 0.0097 14.5 0.1 2.7 3 1 0 3 3 3 1 Adaptin N terminal region DUF2326 PF10088.9 EMC87078.1 - 0.011 15.5 0.1 0.039 13.7 0.1 1.9 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2326) YlbD_coat PF14071.6 EMC87078.1 - 0.013 15.7 1.4 0.013 15.7 1.4 2.2 2 0 0 2 2 2 0 Putative coat protein UCH PF00443.29 EMC87078.1 - 0.044 13.3 1.8 0.075 12.5 1.7 1.6 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase HEAT PF02985.22 EMC87078.1 - 0.05 13.9 0.1 0.75 10.2 0.0 3.0 2 0 0 2 2 2 0 HEAT repeat Muted PF14942.6 EMC87078.1 - 1.4 9.2 10.9 0.45 10.9 1.3 3.1 3 0 0 3 3 3 0 Organelle biogenesis, Muted-like protein CP2 PF04516.15 EMC87079.1 - 6e-34 117.3 0.0 6.7e-34 117.2 0.0 1.0 1 0 0 1 1 1 1 CP2 transcription factor DUF4897 PF16238.5 EMC87079.1 - 0.17 11.8 0.1 0.87 9.4 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4897) LEM PF03020.15 EMC87081.1 - 3.1e-11 42.7 0.2 7e-11 41.5 0.2 1.6 1 0 0 1 1 1 1 LEM domain EpCAM_N PF18635.1 EMC87081.1 - 1.6 8.9 22.3 9.1 6.5 0.1 6.1 6 0 0 6 6 6 0 Epithelial cell adhesion molecule N-terminal domain Abhydrolase_1 PF00561.20 EMC87082.1 - 8.4e-24 84.6 0.1 4.3e-18 65.9 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMC87082.1 - 9e-17 61.1 0.7 1.6e-15 57.0 0.7 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EMC87082.1 - 5.1e-15 56.7 0.1 1e-14 55.7 0.1 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EMC87082.1 - 0.00024 21.0 0.3 0.54 10.0 0.0 3.0 3 0 0 3 3 3 2 Phospholipase/Carboxylesterase DUF2920 PF11144.8 EMC87082.1 - 0.0061 15.8 0.0 0.19 10.9 0.0 2.6 1 1 1 2 2 2 1 Protein of unknown function (DUF2920) UBA_6 PF18039.1 EMC87082.1 - 0.011 15.6 0.2 0.04 13.9 0.1 2.0 2 0 0 2 2 2 0 UBA-like domain FSH1 PF03959.13 EMC87082.1 - 0.014 15.1 0.0 0.036 13.7 0.0 1.7 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 EMC87082.1 - 0.025 14.1 0.1 0.2 11.1 0.0 2.2 2 1 0 2 2 2 0 Prolyl oligopeptidase family Abhydrolase_4 PF08386.10 EMC87082.1 - 0.044 13.9 0.0 0.096 12.8 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein DLH PF01738.18 EMC87082.1 - 0.048 13.2 0.0 8.4 5.9 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family Ndr PF03096.14 EMC87082.1 - 0.082 11.6 0.0 1.2 7.8 0.0 2.0 2 0 0 2 2 2 0 Ndr family Ser_hydrolase PF06821.13 EMC87082.1 - 0.099 12.5 0.0 13 5.6 0.0 2.2 2 0 0 2 2 2 0 Serine hydrolase VirJ PF06057.11 EMC87082.1 - 0.15 11.9 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) BAAT_C PF08840.11 EMC87082.1 - 0.15 11.9 0.0 1.3 8.9 0.0 2.3 2 1 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal LIP PF03583.14 EMC87082.1 - 0.16 11.3 0.0 0.45 9.8 0.0 1.7 1 1 1 2 2 2 0 Secretory lipase Abhydrolase_8 PF06259.12 EMC87082.1 - 0.19 11.4 0.0 0.32 10.6 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase Ribosomal_L34 PF00468.17 EMC87083.1 - 6.8e-20 70.8 2.8 6.9e-20 70.8 2.4 1.2 1 1 0 1 1 1 1 Ribosomal protein L34 DDA1 PF10172.9 EMC87084.1 - 1.8e-30 105.0 0.1 2.7e-30 104.4 0.1 1.3 1 0 0 1 1 1 1 Det1 complexing ubiquitin ligase Anoctamin PF04547.12 EMC87085.1 - 1.8e-56 191.9 0.1 2.4e-56 191.5 0.1 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel RsgA_GTPase PF03193.16 EMC87087.1 - 2.4e-08 34.1 0.0 0.00044 20.2 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MnmE_helical PF12631.7 EMC87087.1 - 2.9e-08 34.1 0.0 2.2e-06 28.0 0.0 2.1 1 1 0 1 1 1 1 MnmE helical domain MMR_HSR1 PF01926.23 EMC87087.1 - 7.6e-05 22.8 0.0 0.00025 21.1 0.1 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EMC87087.1 - 0.0041 16.7 0.0 0.019 14.5 0.0 1.9 1 1 1 2 2 2 1 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.5 EMC87087.1 - 0.017 15.2 0.0 0.026 14.5 0.0 1.2 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain YjeF_N PF03853.15 EMC87088.1 - 1.4e-12 47.8 0.0 2.5e-09 37.2 0.0 2.1 2 0 0 2 2 2 2 YjeF-related protein N-terminus P66_CC PF16563.5 EMC87089.1 - 1.3e-19 69.5 12.2 3.8e-19 68.0 12.2 1.8 1 0 0 1 1 1 1 Coiled-coil and interaction region of P66A and P66B with MBD2 GATA PF00320.27 EMC87089.1 - 1.8e-07 30.7 8.1 1.8e-07 30.7 8.1 2.0 2 0 0 2 2 2 1 GATA zinc finger DUF2299 PF10061.9 EMC87089.1 - 0.066 13.0 1.8 0.07 12.9 0.5 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2299) DUF3619 PF12279.8 EMC87089.1 - 0.17 12.2 0.5 0.46 10.8 0.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) DUF4758 PF15950.5 EMC87089.1 - 0.76 10.1 2.5 1 9.7 0.2 2.2 2 0 0 2 2 2 0 Putative sperm flagellar membrane protein Mu-like_Pro PF10123.9 EMC87089.1 - 0.76 9.3 5.9 0.15 11.6 0.6 2.0 2 0 0 2 2 2 0 Mu-like prophage I protein Cohesin_load PF10345.9 EMC87090.1 - 4.2e-110 369.0 13.1 5.1e-110 368.7 13.1 1.0 1 0 0 1 1 1 1 Cohesin loading factor TPR_12 PF13424.6 EMC87090.1 - 1.8e-08 34.5 9.3 0.0016 18.7 0.1 4.8 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMC87090.1 - 1.7e-07 30.8 5.4 0.22 11.7 0.2 6.7 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EMC87090.1 - 3.3e-06 26.7 14.3 0.00046 19.7 2.2 3.7 2 1 2 4 4 4 2 MalT-like TPR region TPR_8 PF13181.6 EMC87090.1 - 9.8e-05 22.3 5.8 1.3 9.4 0.1 6.0 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_10 PF13374.6 EMC87090.1 - 0.00089 19.1 0.1 3.6 7.6 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EMC87090.1 - 0.0028 17.4 5.1 1.7 8.6 0.0 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat HemY_N PF07219.13 EMC87090.1 - 0.0036 17.5 0.0 0.083 13.1 0.0 2.7 2 0 0 2 2 2 1 HemY protein N-terminus TPR_19 PF14559.6 EMC87090.1 - 0.065 13.8 4.7 1.8 9.1 0.1 4.1 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 EMC87090.1 - 0.092 12.4 0.1 6.4 6.5 0.0 3.3 3 0 0 3 3 3 0 TPR repeat DUF4110 PF13422.6 EMC87090.1 - 0.12 12.5 0.0 20 5.3 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4110) ANAPC3 PF12895.7 EMC87090.1 - 0.76 10.0 8.6 6 7.2 0.6 4.1 3 2 2 5 5 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Surp PF01805.20 EMC87091.1 - 3.8e-20 71.6 3.8 3.7e-12 46.1 0.2 2.7 2 0 0 2 2 2 2 Surp module G-patch PF01585.23 EMC87091.1 - 2.7e-15 56.0 2.8 6.1e-15 54.8 2.8 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EMC87091.1 - 1.5e-07 31.4 1.5 3.1e-06 27.2 0.4 2.7 2 0 0 2 2 2 1 G-patch domain RtcB PF01139.17 EMC87091.1 - 0.013 14.7 0.3 0.018 14.2 0.3 1.1 1 0 0 1 1 1 0 tRNA-splicing ligase RtcB NAM-associated PF14303.6 EMC87091.1 - 2.7 8.7 14.3 3.3 8.4 8.1 2.7 2 1 0 2 2 2 0 No apical meristem-associated C-terminal domain DUF2781 PF10914.8 EMC87092.1 - 6.2e-23 81.8 15.1 5.8e-22 78.7 7.3 2.5 2 1 0 2 2 2 2 Protein of unknown function (DUF2781) F5_F8_type_C PF00754.25 EMC87093.1 - 0.00033 20.8 0.0 0.00079 19.5 0.0 1.6 2 0 0 2 2 2 1 F5/8 type C domain ApeA_NTD1 PF18862.1 EMC87093.1 - 0.0043 16.7 0.0 0.0055 16.3 0.0 1.1 1 0 0 1 1 1 1 ApeA N-terminal domain 1 F_actin_bund_C PF18060.1 EMC87094.1 - 0.061 13.5 0.0 0.073 13.2 0.0 1.0 1 0 0 1 1 1 0 F actin bundling C terminal BORCS8 PF10167.9 EMC87095.1 - 8e-27 93.4 0.1 8.6e-27 93.3 0.1 1.0 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 8 TMEM71 PF15121.6 EMC87095.1 - 0.043 13.5 0.0 0.046 13.4 0.0 1.1 1 0 0 1 1 1 0 TMEM71 protein family Jiraiya PF15038.6 EMC87096.1 - 7.9e-43 145.8 8.0 2.9e-42 144.0 8.0 1.7 1 1 0 1 1 1 1 Jiraiya Phage_holin_3_6 PF07332.11 EMC87096.1 - 0.022 14.8 4.0 0.056 13.5 0.2 2.0 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III TRP PF06011.12 EMC87096.1 - 0.1 11.3 0.8 0.14 10.9 0.8 1.3 1 1 0 1 1 1 0 Transient receptor potential (TRP) ion channel Tmemb_161AB PF10268.9 EMC87098.1 - 4.2e-191 635.7 0.5 6.1e-191 635.2 0.5 1.2 1 1 0 1 1 1 1 Predicted transmembrane protein 161AB KleE PF17394.2 EMC87098.1 - 0.19 11.9 3.6 0.18 12.0 0.8 2.4 3 0 0 3 3 3 0 Uncharacterized KleE stable inheritance protein Arm PF00514.23 EMC87100.1 - 2.9e-09 36.7 0.5 0.086 12.9 0.0 5.4 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 EMC87100.1 - 0.0071 16.3 7.0 0.14 12.2 0.2 4.6 3 1 2 5 5 5 2 Spinocerebellar ataxia type 10 protein domain UBA_3 PF09288.10 EMC87100.1 - 0.05 13.4 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain Surp PF01805.20 EMC87101.1 - 4.9e-15 55.2 1.5 8.3e-10 38.5 0.1 2.6 2 0 0 2 2 2 2 Surp module G-patch PF01585.23 EMC87101.1 - 2.9e-14 52.7 4.2 5.1e-14 51.9 4.2 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EMC87101.1 - 0.0017 18.4 2.7 0.0048 16.9 2.7 1.8 1 0 0 1 1 1 1 G-patch domain DUF4637 PF15470.6 EMC87101.1 - 0.6 9.8 7.8 1.9 8.2 7.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) CDC45 PF02724.14 EMC87101.1 - 0.7 8.1 5.5 1.1 7.5 5.5 1.2 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 EMC87101.1 - 0.86 9.0 13.0 2 7.8 13.0 1.5 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EMC87101.1 - 2.3 6.3 19.1 0.15 10.3 13.2 1.8 2 0 0 2 2 2 0 Nop14-like family WH1 PF00568.23 EMC87103.1 - 9.5e-37 125.3 0.2 1.8e-36 124.5 0.2 1.5 1 0 0 1 1 1 1 WH1 domain GAS PF13851.6 EMC87103.1 - 0.0017 17.8 12.8 0.0017 17.8 12.8 3.0 2 1 1 3 3 3 1 Growth-arrest specific micro-tubule binding CENP-B_N PF04218.13 EMC87103.1 - 0.0076 15.9 0.5 0.022 14.4 0.5 1.8 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain VID27_PH PF17747.1 EMC87103.1 - 0.15 12.4 1.9 3.6 7.9 0.1 2.5 2 0 0 2 2 2 0 VID27 PH-like domain DUF3287 PF11690.8 EMC87103.1 - 0.81 9.4 4.9 1.2 8.8 3.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3287) DUF3461 PF11944.8 EMC87103.1 - 1.1 9.4 13.7 0.031 14.4 3.7 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3461) Flu_M1_C PF08289.11 EMC87103.1 - 1.2 9.4 5.0 0.64 10.3 0.9 2.6 2 1 1 3 3 3 0 Influenza Matrix protein (M1) C-terminal domain PKcGMP_CC PF16808.5 EMC87103.1 - 2 8.3 14.2 0.099 12.5 2.3 3.6 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Leu_zip PF15294.6 EMC87103.1 - 3.5 7.1 29.3 13 5.2 13.1 3.1 2 1 1 3 3 3 0 Leucine zipper CorA PF01544.18 EMC87103.1 - 5.8 6.1 9.2 11 5.2 9.2 1.5 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Helicase_C PF00271.31 EMC87104.1 - 5.1e-28 97.6 0.1 1.3e-27 96.3 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Coatomer_E PF04733.14 EMC87105.1 - 8.9e-73 245.2 1.3 9.9e-73 245.1 1.3 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 EMC87105.1 - 4.8e-09 36.6 5.3 1.3e-05 25.7 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMC87105.1 - 1.6e-06 28.4 0.6 0.0059 17.3 0.0 2.8 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMC87105.1 - 1.6e-05 24.6 4.5 0.0004 20.3 0.1 2.9 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EMC87105.1 - 0.0001 22.8 0.1 0.0019 18.8 0.0 2.4 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMC87105.1 - 0.00011 22.4 0.8 0.0019 18.4 0.0 2.4 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EMC87105.1 - 0.00052 19.9 0.8 0.0023 17.9 0.0 2.4 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EMC87105.1 - 0.0013 18.5 3.3 0.0033 17.2 0.1 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC87105.1 - 0.0015 18.7 0.7 0.0047 17.1 0.5 2.0 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 EMC87105.1 - 0.01 16.0 1.1 6.5 7.2 0.0 3.3 3 0 0 3 3 3 0 PPR repeat HemY_N PF07219.13 EMC87105.1 - 0.012 15.8 0.2 2.7 8.2 0.1 2.3 2 0 0 2 2 2 0 HemY protein N-terminus CysG_dimeriser PF10414.9 EMC87105.1 - 0.02 14.6 0.1 0.043 13.5 0.1 1.6 1 0 0 1 1 1 0 Sirohaem synthase dimerisation region TPR_6 PF13174.6 EMC87105.1 - 0.16 12.7 0.9 0.88 10.4 0.0 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat Com_YlbF PF06133.11 EMC87105.1 - 0.19 12.4 0.1 0.19 12.4 0.1 2.1 2 1 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA PPR_2 PF13041.6 EMC87105.1 - 0.36 11.1 2.1 35 4.7 0.2 3.1 3 0 0 3 3 3 0 PPR repeat family TPR_10 PF13374.6 EMC87105.1 - 0.7 9.8 0.1 0.7 9.8 0.1 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TRAM_LAG1_CLN8 PF03798.16 EMC87106.1 - 2.6e-20 73.0 27.2 1.1e-15 57.9 5.9 2.0 2 0 0 2 2 2 2 TLC domain 2TM PF13239.6 EMC87106.1 - 5.2 7.5 7.6 0.75 10.1 2.2 2.2 2 0 0 2 2 2 0 2TM domain TGF_beta PF00019.20 EMC87107.1 - 1.5e-34 119.1 0.2 2.7e-34 118.3 0.2 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 EMC87107.1 - 4.6e-06 26.5 0.0 6.2e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TSP_C PF05735.12 EMC87109.1 - 1.1e-98 329.1 1.1 1.4e-98 328.7 1.1 1.1 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.18 EMC87109.1 - 3.9e-55 183.2 133.7 1.4e-11 43.9 11.2 9.4 7 2 1 8 8 8 8 Thrombospondin type 3 repeat EGF_CA PF07645.15 EMC87109.1 - 5.4e-18 64.9 44.7 5.8e-09 36.0 6.4 5.7 4 0 0 4 4 4 4 Calcium-binding EGF domain COMP PF11598.8 EMC87109.1 - 6.2e-17 61.8 1.8 1.3e-16 60.7 1.8 1.6 1 0 0 1 1 1 1 Cartilage oligomeric matrix protein cEGF PF12662.7 EMC87109.1 - 9.6e-12 44.6 27.5 1.8e-06 27.8 3.5 5.8 4 0 0 4 4 4 3 Complement Clr-like EGF-like EGF_3 PF12947.7 EMC87109.1 - 8.9e-08 32.2 53.7 0.00031 20.9 4.3 6.1 6 0 0 6 6 6 4 EGF domain EGF_MSP1_1 PF12946.7 EMC87109.1 - 0.012 15.6 4.7 0.012 15.6 4.7 4.7 4 0 0 4 4 4 0 MSP1 EGF domain 1 EGF PF00008.27 EMC87109.1 - 0.02 15.2 2.4 0.02 15.2 2.4 5.9 5 0 0 5 5 5 0 EGF-like domain BSMAP PF12280.8 EMC87110.1 - 3.6e-65 219.7 0.0 4.5e-65 219.4 0.0 1.1 1 0 0 1 1 1 1 Brain specific membrane anchored protein TrkA_TMD PF18613.1 EMC87110.1 - 0.24 10.9 5.0 0.43 10.0 5.0 1.4 1 0 0 1 1 1 0 Tyrosine kinase receptor A trans-membrane domain DNA_repr_REX1B PF14966.6 EMC87111.1 - 7.9e-09 36.1 0.0 8.6e-09 35.9 0.0 1.0 1 0 0 1 1 1 1 DNA repair REX1-B FlgM PF04316.13 EMC87111.1 - 0.055 13.8 0.6 0.078 13.4 0.6 1.2 1 0 0 1 1 1 0 Anti-sigma-28 factor, FlgM KxDL PF10241.9 EMC87112.1 - 4.1e-23 81.5 1.6 6.5e-23 80.8 1.6 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein DUF4692 PF15763.5 EMC87112.1 - 0.34 11.4 5.1 3.6 8.0 5.1 2.0 1 1 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) TPR_1 PF00515.28 EMC87113.1 - 3.3e-15 55.2 5.3 1.3e-05 24.8 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat FKBP_C PF00254.28 EMC87113.1 - 1.2e-14 54.4 0.0 2.2e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.17 EMC87113.1 - 5.4e-13 48.0 3.3 3.8e-05 23.5 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMC87113.1 - 9.3e-09 35.8 1.4 0.0003 21.4 0.1 2.8 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 EMC87113.1 - 1.2e-08 35.0 0.0 4e-05 24.1 0.0 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMC87113.1 - 1.4e-08 34.7 2.4 0.0004 20.4 0.2 2.6 2 0 0 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.6 EMC87113.1 - 4.9e-07 29.4 0.5 0.0012 18.8 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EMC87113.1 - 6.1e-07 29.0 1.4 0.00022 20.9 0.0 3.1 2 1 1 3 3 3 2 TPR repeat TPR_9 PF13371.6 EMC87113.1 - 9.6e-07 28.9 0.3 6.1e-06 26.3 0.0 2.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EMC87113.1 - 1.8e-06 27.6 0.6 0.0098 15.9 0.0 3.6 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMC87113.1 - 3.8e-05 24.1 1.0 0.0089 16.5 0.1 2.6 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMC87113.1 - 4.1e-05 23.8 0.8 0.0019 18.4 0.3 3.0 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 EMC87113.1 - 0.00013 22.1 1.1 0.021 15.1 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC87113.1 - 0.00025 21.2 0.9 0.0014 18.8 0.1 2.5 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.8 EMC87113.1 - 0.0022 17.0 0.2 0.003 16.6 0.2 1.1 1 0 0 1 1 1 1 NMDA receptor-regulated protein 1 TPR_10 PF13374.6 EMC87113.1 - 0.0043 16.9 3.8 4.8 7.2 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMC87113.1 - 0.013 16.1 0.7 0.74 10.6 0.1 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_20 PF14561.6 EMC87113.1 - 0.11 12.8 0.3 0.34 11.3 0.3 1.9 1 1 0 1 1 1 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EMC87113.1 - 0.15 12.5 0.6 8 6.9 0.1 2.3 1 1 1 2 2 2 0 Alkyl sulfatase dimerisation NAD_binding_5 PF07994.12 EMC87114.1 - 6.1e-145 482.6 0.0 7.4e-145 482.3 0.0 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 EMC87114.1 - 8.5e-48 161.1 0.1 1.4e-47 160.4 0.1 1.4 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase SSDP PF04503.13 EMC87115.1 - 1.1e-32 114.5 29.4 1.7e-32 113.9 29.4 1.3 1 0 0 1 1 1 1 Single-stranded DNA binding protein, SSDP TGF_beta PF00019.20 EMC87116.1 - 8.4e-28 97.4 2.9 9.8e-28 97.2 2.9 1.0 1 0 0 1 1 1 1 Transforming growth factor beta like domain Peptidase_C15 PF01470.17 EMC87117.1 - 5.1e-05 23.5 0.0 5.6e-05 23.4 0.0 1.0 1 0 0 1 1 1 1 Pyroglutamyl peptidase LSM PF01423.22 EMC87118.1 - 4.9e-17 61.4 0.0 7.1e-17 60.9 0.0 1.3 1 0 0 1 1 1 1 LSM domain PDEase_I PF00233.19 EMC87120.1 - 2.3e-91 305.8 4.9 2.3e-91 305.8 4.9 1.6 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase PDE4_UCR PF18100.1 EMC87120.1 - 1.9e-19 70.4 1.9 3.9e-19 69.4 0.2 2.4 2 1 0 2 2 2 1 Phosphodiesterase 4 upstream conserved regions (UCR) DUF4474 PF14751.6 EMC87120.1 - 0.16 11.4 0.3 4.2 6.7 0.0 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4474) Ras PF00071.22 EMC87121.1 - 2.1e-61 206.3 0.8 2.4e-61 206.0 0.8 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC87121.1 - 1.1e-33 115.9 0.5 1.7e-33 115.4 0.5 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC87121.1 - 1.5e-14 53.9 0.1 1.9e-14 53.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EMC87121.1 - 5.3e-06 26.0 0.1 8.1e-05 22.1 0.0 2.0 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EMC87121.1 - 0.00015 21.8 0.0 0.00025 21.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC87121.1 - 0.00061 19.4 0.0 0.0024 17.4 0.0 1.9 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EMC87121.1 - 0.00078 18.9 0.1 0.0011 18.4 0.1 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 EMC87121.1 - 0.014 15.0 0.0 1.5 8.3 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_24 PF13479.6 EMC87121.1 - 0.016 15.0 0.5 0.038 13.7 0.5 1.7 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EMC87121.1 - 0.021 14.7 0.0 2.4 8.0 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase DUF2757 PF10955.8 EMC87121.1 - 0.027 14.7 0.1 0.056 13.7 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2757) AAA_16 PF13191.6 EMC87121.1 - 0.029 14.8 0.0 0.098 13.0 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 EMC87121.1 - 0.046 13.0 0.0 0.55 9.5 0.0 2.2 2 0 0 2 2 2 0 Septin G-alpha PF00503.20 EMC87121.1 - 0.082 12.1 1.0 5.2 6.1 0.0 2.8 1 1 1 2 2 2 0 G-protein alpha subunit Mpv17_PMP22 PF04117.12 EMC87122.1 - 2.5e-30 104.5 0.9 2.5e-30 104.5 0.9 1.8 2 0 0 2 2 2 1 Mpv17 / PMP22 family GILT PF03227.16 EMC87123.1 - 2.6e-30 104.8 0.1 3.5e-30 104.4 0.1 1.2 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) PI3K_P85_iSH2 PF16454.5 EMC87124.1 - 1.1e-60 203.9 22.3 1.6e-60 203.3 22.3 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain SH2 PF00017.24 EMC87124.1 - 6.2e-41 138.4 0.1 8.6e-20 70.6 0.0 2.7 2 0 0 2 2 2 2 SH2 domain RhoGAP PF00620.27 EMC87124.1 - 6.5e-26 91.0 1.1 5.7e-25 87.9 0.0 2.7 2 1 1 3 3 3 1 RhoGAP domain SH3_1 PF00018.28 EMC87124.1 - 9.4e-05 21.9 1.1 0.0071 15.9 0.0 3.3 4 0 0 4 4 4 1 SH3 domain SH3_9 PF14604.6 EMC87124.1 - 0.00067 19.5 0.2 0.0023 17.7 0.2 2.0 1 1 0 1 1 1 1 Variant SH3 domain ATG11 PF10377.9 EMC87124.1 - 0.022 14.8 0.8 0.022 14.8 0.8 2.0 2 0 0 2 2 2 0 Autophagy-related protein 11 Mod_r PF07200.13 EMC87124.1 - 1.9 8.6 22.8 0.42 10.7 7.1 2.6 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein BRE1 PF08647.11 EMC87124.1 - 3.1 7.9 15.4 0.14 12.2 6.7 2.5 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase fn3 PF00041.21 EMC87125.1 - 5.8e-10 39.4 0.0 2.3e-06 27.9 0.0 3.4 3 0 0 3 3 3 2 Fibronectin type III domain DUF2840 PF11000.8 EMC87125.1 - 0.015 15.1 0.0 0.026 14.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2840) Arrestin_N PF00339.29 EMC87126.1 - 1.5e-30 106.2 0.0 6.5e-29 100.9 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EMC87126.1 - 7.2e-29 100.9 0.1 7.8e-24 84.6 0.0 2.2 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Rgp1 PF08737.10 EMC87126.1 - 0.0028 16.9 0.0 0.02 14.1 0.0 2.0 2 0 0 2 2 2 1 Rgp1 Vps26 PF03643.15 EMC87126.1 - 0.0093 15.0 0.0 0.013 14.6 0.0 1.2 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 PEX11 PF05648.14 EMC87127.1 - 9e-39 133.2 0.0 1e-38 133.1 0.0 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Nodulin-like PF06813.13 EMC87127.1 - 0.021 14.3 0.0 0.032 13.7 0.0 1.2 1 0 0 1 1 1 0 Nodulin-like C1_1 PF00130.22 EMC87128.1 - 0.13 12.1 0.8 0.28 11.1 0.8 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_Tyr PF07714.17 EMC87129.1 - 5.3e-96 320.9 0.0 1.4e-95 319.5 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Recep_L_domain PF01030.24 EMC87129.1 - 1.6e-57 192.4 1.7 9.9e-29 99.7 0.1 2.4 2 0 0 2 2 2 2 Receptor L domain Pkinase PF00069.25 EMC87129.1 - 3e-40 138.3 0.0 5.4e-40 137.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.20 EMC87129.1 - 4.1e-36 124.1 43.1 1e-35 122.8 43.1 1.7 1 0 0 1 1 1 1 Furin-like cysteine rich region fn3 PF00041.21 EMC87129.1 - 2.6e-21 75.7 2.7 8e-08 32.5 0.0 5.2 5 1 0 5 5 5 4 Fibronectin type III domain Insulin_TMD PF17870.1 EMC87129.1 - 5.8e-21 74.3 2.8 1.2e-20 73.3 2.8 1.6 1 0 0 1 1 1 1 Insulin receptor trans-membrane segment Kinase-like PF14531.6 EMC87129.1 - 0.0006 19.2 0.0 0.001 18.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like B2 PF11473.8 EMC87129.1 - 0.092 12.6 0.0 0.37 10.6 0.1 2.1 2 0 0 2 2 2 0 RNA binding protein B2 Myosin_head PF00063.21 EMC87130.1 - 8.5e-196 652.2 24.2 7.3e-166 553.2 5.9 3.4 4 1 0 4 4 4 2 Myosin head (motor domain) RhoGAP PF00620.27 EMC87130.1 - 1.6e-47 161.1 0.2 5.6e-47 159.4 0.2 2.0 1 0 0 1 1 1 1 RhoGAP domain RA PF00788.23 EMC87130.1 - 1.2e-15 57.9 1.3 4.1e-15 56.2 0.1 2.6 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain IQ PF00612.27 EMC87130.1 - 2.1e-08 33.2 20.6 0.0023 17.6 0.5 4.3 4 0 0 4 4 4 3 IQ calmodulin-binding motif C1_1 PF00130.22 EMC87130.1 - 0.00076 19.3 17.2 0.0016 18.3 17.2 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) AAA_22 PF13401.6 EMC87130.1 - 0.0049 17.1 1.1 0.42 10.9 0.1 3.4 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 EMC87130.1 - 0.068 13.5 0.2 1.9 8.8 0.0 3.2 2 0 0 2 2 2 0 AAA ATPase domain T2SSE PF00437.20 EMC87130.1 - 0.07 12.2 0.0 0.2 10.7 0.0 1.7 1 0 0 1 1 1 0 Type II/IV secretion system protein QWRF PF04484.12 EMC87131.1 - 0.0013 18.5 2.7 0.0016 18.2 2.7 1.1 1 0 0 1 1 1 1 QWRF family DLP_helical PF18709.1 EMC87131.1 - 0.053 12.7 0.4 0.053 12.7 0.4 2.2 2 0 0 2 2 2 0 Dynamin-like helical domain DUF1168 PF06658.12 EMC87131.1 - 0.17 11.7 3.8 0.2 11.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) TED_complement PF07678.14 EMC87132.1 - 1.9e-106 355.6 0.1 3.3e-106 354.8 0.1 1.4 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M_BRD PF07703.14 EMC87132.1 - 6.8e-40 136.6 0.6 1.4e-37 129.1 0.1 4.1 3 1 0 3 3 3 1 Alpha-2-macroglobulin bait region domain Methyltransf_FA PF12248.8 EMC87132.1 - 1.7e-32 111.8 0.4 4.7e-32 110.3 0.4 1.9 1 0 0 1 1 1 1 Farnesoic acid 0-methyl transferase A2M PF00207.22 EMC87132.1 - 7.8e-31 105.8 2.3 5.1e-30 103.2 0.1 3.4 3 0 0 3 3 3 1 Alpha-2-macroglobulin family A2M_recep PF07677.14 EMC87132.1 - 9.5e-27 93.6 0.0 2.8e-26 92.0 0.0 1.9 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain MG4 PF17789.1 EMC87132.1 - 5.5e-12 45.7 0.5 1.2e-10 41.4 0.0 3.3 3 0 0 3 3 3 1 Macroglobulin domain MG4 MG2 PF01835.19 EMC87132.1 - 2.3e-11 44.0 0.0 1.1e-10 41.9 0.0 2.3 2 0 0 2 2 1 1 MG2 domain MG3 PF17791.1 EMC87132.1 - 8.9e-11 41.9 0.0 2.6e-10 40.4 0.0 1.8 1 0 0 1 1 1 1 Macroglobulin domain MG3 Kazal_2 PF07648.15 EMC87132.1 - 2.4e-07 30.8 6.3 7.5e-07 29.2 6.3 2.0 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain MG1 PF17790.1 EMC87132.1 - 0.00034 21.0 0.0 0.0021 18.4 0.0 2.5 1 0 0 1 1 1 1 Macroglobulin domain MG1 Kazal_1 PF00050.21 EMC87132.1 - 0.0012 18.8 6.8 0.0038 17.2 6.8 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Rib PF08428.10 EMC87132.1 - 0.025 14.6 0.4 0.12 12.4 0.1 2.3 2 0 0 2 2 2 0 Rib/alpha-like repeat 7tm_1 PF00001.21 EMC87133.1 - 4.3e-45 154.1 19.8 8.7e-45 153.1 19.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC87133.1 - 2e-07 31.1 11.8 4.5e-07 29.9 11.8 1.5 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC87133.1 - 0.023 14.3 15.1 0.042 13.5 15.1 1.4 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx TRIC PF05197.13 EMC87134.1 - 3.8e-81 271.3 7.2 4.7e-81 271.0 7.2 1.1 1 0 0 1 1 1 1 TRIC channel UPF0126 PF03458.13 EMC87134.1 - 0.11 12.3 0.3 1.2 9.0 0.0 2.4 2 0 0 2 2 2 0 UPF0126 domain TMEM208_SND2 PF05620.11 EMC87134.1 - 4 7.2 7.1 0.51 10.1 0.6 2.6 3 0 0 3 3 3 0 SRP-independent targeting protein 2/TMEM208 Med26_C PF15693.5 EMC87135.1 - 9.5e-93 309.4 1.3 1.1e-92 309.3 1.3 1.0 1 0 0 1 1 1 1 Mediator complex subunit 26 C-terminal SLY PF12485.8 EMC87135.1 - 0.016 15.9 1.1 0.023 15.4 1.1 1.2 1 0 0 1 1 1 0 Lymphocyte signaling adaptor protein Pullulanase_N2 PF17967.1 EMC87135.1 - 0.032 15.1 0.1 0.046 14.6 0.1 1.3 1 0 0 1 1 1 0 Pullulanase N2 domain UBD PF16455.5 EMC87135.1 - 0.053 13.8 0.1 0.17 12.1 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin-binding domain TPT PF03151.16 EMC87136.1 - 1.5e-68 231.3 14.2 1.7e-68 231.1 14.2 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EMC87136.1 - 2.5e-13 50.4 19.8 9.8e-10 38.7 11.6 2.1 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 EMC87136.1 - 1.4e-05 24.5 15.5 1.6e-05 24.2 15.5 1.1 1 0 0 1 1 1 1 UAA transporter family Nuc_sug_transp PF04142.15 EMC87136.1 - 0.062 12.5 8.0 0.098 11.8 8.0 1.4 1 1 0 1 1 1 0 Nucleotide-sugar transporter YwiC PF14256.6 EMC87136.1 - 0.44 10.9 4.8 0.17 12.2 0.4 2.2 1 1 1 2 2 2 0 YwiC-like protein DUF4614 PF15391.6 EMC87137.1 - 2.2e-07 31.0 0.4 2.2e-07 31.0 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4614) Calreticulin PF00262.18 EMC87138.1 - 1.6e-26 93.0 0.2 1.8e-26 92.9 0.2 1.0 1 0 0 1 1 1 1 Calreticulin family Adap_comp_sub PF00928.21 EMC87139.1 - 7.9e-93 310.6 0.7 1.4e-92 309.8 0.4 1.5 2 0 0 2 2 2 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EMC87139.1 - 3.7e-05 23.7 0.8 6.4e-05 22.9 0.8 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF5482 PF17579.2 EMC87139.1 - 0.015 15.2 0.0 0.18 11.7 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5482) muHD PF10291.9 EMC87139.1 - 0.03 13.8 0.0 0.061 12.8 0.0 1.4 1 0 0 1 1 1 0 Muniscin C-terminal mu homology domain AAA_10 PF12846.7 EMC87140.1 - 0.0033 16.4 3.0 0.0037 16.3 3.0 1.0 1 0 0 1 1 1 1 AAA-like domain UPF0172 PF03665.13 EMC87140.1 - 0.023 14.7 1.1 0.026 14.6 1.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) DUF5384 PF17358.2 EMC87140.1 - 0.33 11.0 12.0 0.37 10.8 12.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5384) DUF1754 PF08555.10 EMC87140.1 - 0.44 11.4 19.8 0.36 11.6 15.9 2.4 2 1 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) DUF3395 PF11875.8 EMC87140.1 - 4.7 7.1 13.3 0.31 10.9 4.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3395) DUF1764 PF08576.10 EMC87140.1 - 6.3 7.8 10.3 8 7.4 10.3 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) EF-hand_7 PF13499.6 EMC87141.1 - 2.4e-15 56.8 3.7 8.2e-12 45.4 1.5 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EMC87141.1 - 4.8e-11 41.4 9.8 3.8e-05 22.9 0.1 4.1 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EMC87141.1 - 2.4e-10 39.5 8.4 0.0014 18.4 0.3 4.2 4 1 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 EMC87141.1 - 0.00015 21.6 4.7 0.0074 16.1 0.5 2.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EMC87141.1 - 0.0034 16.8 0.2 0.0034 16.8 0.2 3.5 4 0 0 4 4 4 1 EF hand SPARC_Ca_bdg PF10591.9 EMC87141.1 - 0.057 13.7 0.9 0.15 12.4 0.9 1.7 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 EMC87141.1 - 0.061 13.5 4.3 0.12 12.5 1.8 2.3 2 1 0 2 2 2 0 Dockerin type I domain EF-hand_13 PF17958.1 EMC87141.1 - 0.075 12.8 0.0 14 5.6 0.0 3.0 2 1 0 2 2 2 0 EF-hand domain Mob1_phocein PF03637.17 EMC87142.1 - 9.6e-84 279.5 0.2 1.1e-83 279.3 0.2 1.1 1 0 0 1 1 1 1 Mob1/phocein family PHR PF08005.12 EMC87145.1 - 5e-54 183.1 1.1 7.9e-54 182.4 1.1 1.3 1 0 0 1 1 1 1 PHR domain BTB PF00651.31 EMC87145.1 - 6.8e-22 77.8 0.4 5.8e-20 71.6 0.0 2.8 2 1 1 3 3 3 1 BTB/POZ domain BACK PF07707.15 EMC87145.1 - 2.8e-10 40.2 0.9 7e-09 35.7 0.2 3.0 1 1 2 3 3 3 1 BTB And C-terminal Kelch DUF4082 PF13313.6 EMC87145.1 - 0.12 12.4 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4082) zf-C4 PF00105.18 EMC87146.1 - 4.9e-33 113.4 13.6 1.2e-32 112.2 13.6 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 EMC87146.1 - 2.5e-29 102.3 3.8 5.6e-29 101.2 3.8 1.6 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-A20 PF01754.16 EMC87147.1 - 1.1e-12 47.6 6.9 2.5e-12 46.5 6.9 1.6 1 0 0 1 1 1 1 A20-like zinc finger zf-AN1 PF01428.16 EMC87147.1 - 3.4e-09 36.7 6.8 3.4e-09 36.7 6.8 2.7 3 0 0 3 3 3 1 AN1-like Zinc finger Hydrolase_4 PF12146.8 EMC87148.1 - 7.4e-07 28.7 0.0 0.00071 18.9 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMC87148.1 - 0.00026 20.7 0.1 0.0056 16.4 0.0 2.1 1 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EMC87148.1 - 0.012 15.1 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family FSH1 PF03959.13 EMC87148.1 - 0.022 14.4 0.0 0.035 13.8 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) UPF0227 PF05728.12 EMC87148.1 - 0.025 14.5 0.0 0.036 14.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Abhydrolase_6 PF12697.7 EMC87148.1 - 0.047 14.3 0.0 7 7.2 0.0 2.3 1 1 1 2 2 2 0 Alpha/beta hydrolase family CUT PF02376.15 EMC87150.1 - 5.3e-32 109.8 0.5 8.4e-32 109.2 0.5 1.3 1 0 0 1 1 1 1 CUT domain Homeodomain PF00046.29 EMC87150.1 - 7.7e-10 38.5 1.4 1.5e-09 37.5 1.4 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC87150.1 - 0.0024 17.8 0.0 0.0061 16.4 0.0 1.7 1 0 0 1 1 1 1 Homeobox KN domain HLH PF00010.26 EMC87151.1 - 9.2e-10 38.3 1.2 1.8e-09 37.4 1.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain CDC45 PF02724.14 EMC87151.1 - 0.15 10.3 8.0 0.2 9.9 8.0 1.1 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.11 EMC87151.1 - 8.7 4.8 5.6 12 4.3 5.6 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 UCR_6-4kD PF08997.10 EMC87152.1 - 1e-18 66.9 2.1 1.2e-18 66.7 2.1 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex, 6.4kD protein QCR10 PF09796.9 EMC87152.1 - 0.00016 21.7 2.3 0.0016 18.5 2.3 1.9 1 1 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) IPTL-CTERM PF18203.1 EMC87152.1 - 0.2 11.6 1.1 0.42 10.6 1.1 1.5 1 0 0 1 1 1 0 IPTL-CTERM motif MBDa PF16564.5 EMC87153.1 - 3.6e-31 107.2 1.0 5.3e-31 106.6 1.0 1.3 1 0 0 1 1 1 1 p55-binding region of Methyl-CpG-binding domain proteins MBD MBD_C PF14048.6 EMC87153.1 - 1.8e-26 92.7 0.3 4.7e-26 91.3 0.0 1.7 2 0 0 2 2 2 1 C-terminal domain of methyl-CpG binding protein 2 and 3 MBD PF01429.19 EMC87153.1 - 5.3e-10 38.9 0.9 1.9e-05 24.3 0.0 2.3 1 1 1 2 2 2 2 Methyl-CpG binding domain RasGAP PF00616.19 EMC87153.1 - 0.034 13.8 0.0 0.055 13.2 0.0 1.4 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase NUMOD1 PF07453.13 EMC87153.1 - 0.12 12.7 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 NUMOD1 domain KH_1 PF00013.29 EMC87154.1 - 6.2e-22 77.2 1.5 2.1e-14 53.1 0.1 2.7 3 0 0 3 3 3 2 KH domain zf-C3HC4_3 PF13920.6 EMC87154.1 - 1.8e-10 40.5 10.2 2.7e-10 39.9 10.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC87154.1 - 1.9e-05 24.9 11.4 3.3e-05 24.1 11.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EMC87154.1 - 0.00086 19.1 10.9 0.0015 18.4 10.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC87154.1 - 0.003 17.4 11.2 0.0055 16.5 11.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EMC87154.1 - 0.079 12.9 10.7 0.15 12.1 10.7 1.4 1 0 0 1 1 1 0 zinc-RING finger domain KH_2 PF07650.17 EMC87154.1 - 0.13 12.1 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 KH domain zf-RING_UBOX PF13445.6 EMC87154.1 - 0.17 11.9 7.1 0.39 10.8 7.1 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EMC87154.1 - 1.5 9.1 9.6 4 7.7 9.6 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EMC87154.1 - 3.2 7.6 9.4 7.4 6.5 9.4 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain 7tm_4 PF13853.6 EMC87155.1 - 1e-25 91.1 2.1 1.1e-25 90.9 2.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC87155.1 - 8.3e-05 22.0 4.4 0.00011 21.7 4.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF5345 PF17280.2 EMC87155.1 - 0.17 11.9 5.5 0.15 12.1 1.9 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5345) DUF4519 PF15012.6 EMC87155.1 - 1.4 9.2 0.0 1.4 9.2 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4519) UL45 PF05473.12 EMC87156.1 - 0.06 13.0 0.6 0.065 12.9 0.6 1.1 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like PSP1 PF04468.12 EMC87158.1 - 0.02 15.1 0.1 0.052 13.8 0.1 1.7 1 0 0 1 1 1 0 PSP1 C-terminal conserved region Ten_N PF06484.12 EMC87159.1 - 2.9e-36 126.1 3.8 3.3e-36 126.0 3.8 1.0 1 0 0 1 1 1 1 Teneurin Intracellular Region dCMP_cyt_deam_1 PF00383.23 EMC87160.1 - 1.6e-28 98.5 0.2 2.6e-28 97.9 0.2 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EMC87160.1 - 9.3e-15 54.6 0.0 1.1e-14 54.4 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase APOBEC3 PF18771.1 EMC87160.1 - 0.023 14.8 0.2 0.051 13.7 0.1 1.7 2 0 0 2 2 2 0 APOBEC3 APOBEC4_like PF18774.1 EMC87160.1 - 0.026 14.4 0.3 0.083 12.8 0.1 1.8 1 1 1 2 2 2 0 APOBEC4-like -AID/APOBEC-deaminase Rap_GAP PF02145.15 EMC87162.1 - 4e-46 156.9 0.0 1.1e-44 152.2 0.0 2.2 1 1 0 1 1 1 1 Rap/ran-GAP MA3 PF02847.17 EMC87165.1 - 4.3e-48 162.0 0.3 3.8e-25 88.1 0.3 2.1 2 0 0 2 2 2 2 MA3 domain HABP4_PAI-RBP1 PF04774.15 EMC87165.1 - 0.06 14.2 3.4 0.096 13.5 0.0 2.3 2 0 0 2 2 2 0 Hyaluronan / mRNA binding family LRR_8 PF13855.6 EMC87166.1 - 3e-56 187.0 68.0 1.3e-11 44.0 7.1 8.7 3 3 5 10 10 10 9 Leucine rich repeat LRR_4 PF12799.7 EMC87166.1 - 3.4e-39 132.2 73.0 1.6e-06 28.3 3.6 10.8 5 3 7 13 13 13 13 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC87166.1 - 3e-12 46.4 35.8 0.0018 17.8 2.0 5.8 2 2 4 6 6 6 5 Leucine-rich repeat LRR_5 PF13306.6 EMC87166.1 - 2.4e-06 27.6 2.1 0.2 11.6 0.6 4.3 1 1 4 5 5 5 4 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EMC87166.1 - 5.6e-06 26.2 61.4 4.2 8.3 0.7 17.1 18 2 0 18 18 18 2 Leucine Rich Repeat HERV-K_REC PF15695.5 EMC87166.1 - 0.074 13.1 1.3 2.7 8.1 0.1 3.5 3 0 0 3 3 3 0 Rec (regulator of expression encoded by corf) of HERV-K-113 RsmF_methylt_CI PF17126.5 EMC87166.1 - 0.2 11.7 1.7 25 5.0 0.0 4.9 4 2 0 6 6 6 0 RsmF rRNA methyltransferase first C-terminal domain SUFU_C PF12470.8 EMC87166.1 - 0.57 10.2 2.6 0.87 9.6 0.6 2.2 2 0 0 2 2 2 0 Suppressor of Fused Gli/Ci N terminal binding domain 7tm_1 PF00001.21 EMC87167.1 - 3.2e-78 262.7 0.0 4.2e-78 262.3 0.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC87167.1 - 2.1e-10 40.4 12.1 1.6e-06 27.7 4.8 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC87167.1 - 3.4e-07 30.3 7.0 1.1e-05 25.3 4.4 2.2 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC87167.1 - 1.8e-05 24.5 12.9 1.8e-05 24.5 12.9 2.3 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx T2SSM PF04612.12 EMC87167.1 - 0.23 11.5 0.1 0.44 10.6 0.1 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M Acyltransferase PF01553.21 EMC87168.1 - 3.5e-22 78.5 0.0 8.9e-22 77.2 0.0 1.8 1 0 0 1 1 1 1 Acyltransferase Zona_pellucida PF00100.23 EMC87169.1 - 1.8e-33 116.4 7.9 2.2e-33 116.2 7.9 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain Myelin_MBP PF01669.17 EMC87169.1 - 0.14 12.7 0.0 0.21 12.2 0.0 1.3 1 0 0 1 1 1 0 Myelin basic protein AMP-binding PF00501.28 EMC87170.1 - 3.4e-112 375.2 0.0 4.4e-112 374.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMC87170.1 - 0.00061 20.7 0.0 0.0014 19.5 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DHHC PF01529.20 EMC87171.1 - 3.6e-36 124.2 8.1 5e-36 123.8 8.1 1.2 1 0 0 1 1 1 1 DHHC palmitoyltransferase SH3_2 PF07653.17 EMC87171.1 - 1.5e-08 34.2 0.5 5.2e-08 32.4 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 EMC87171.1 - 0.014 15.3 0.0 0.038 13.8 0.0 1.8 2 0 0 2 2 2 0 Variant SH3 domain V-SNARE PF05008.15 EMC87172.1 - 3.5e-24 85.0 0.2 3.5e-24 85.0 0.2 2.3 3 0 0 3 3 3 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 EMC87172.1 - 9.9e-22 77.0 6.8 1.4e-20 73.4 6.0 2.4 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Laminin_II PF06009.12 EMC87172.1 - 0.0009 19.3 0.3 0.06 13.4 0.0 2.2 2 0 0 2 2 2 1 Laminin Domain II Mer2 PF09074.10 EMC87172.1 - 0.007 16.2 1.6 0.61 9.9 0.0 2.1 1 1 1 2 2 2 2 Mer2 DUF1664 PF07889.12 EMC87172.1 - 0.019 15.0 2.3 0.34 10.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Peptidase_S46 PF10459.9 EMC87172.1 - 0.025 13.2 4.7 0.031 12.9 4.7 1.0 1 0 0 1 1 1 0 Peptidase S46 DUF745 PF05335.13 EMC87172.1 - 0.077 12.7 1.4 1.7 8.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) MetOD2 PF18548.1 EMC87172.1 - 0.091 12.9 5.5 4.6 7.4 0.1 2.3 2 0 0 2 2 2 0 Metanogen output domain 2 Exonuc_VII_L PF02601.15 EMC87172.1 - 0.13 11.8 8.4 0.57 9.7 8.4 1.8 1 1 0 1 1 1 0 Exonuclease VII, large subunit SKA2 PF16740.5 EMC87172.1 - 0.35 10.7 5.0 0.29 10.9 0.3 2.5 1 1 2 3 3 3 0 Spindle and kinetochore-associated protein 2 DegQ PF08181.11 EMC87172.1 - 0.42 10.7 3.7 0.57 10.3 1.7 2.2 3 0 0 3 3 3 0 DegQ (SacQ) family TMPIT PF07851.13 EMC87172.1 - 4.2 6.5 5.1 11 5.2 0.1 2.1 1 1 1 2 2 2 0 TMPIT-like protein CTNNB1_binding PF08347.11 EMC87173.1 - 4.6e-38 131.4 7.8 4.6e-38 131.4 7.8 2.6 2 1 0 2 2 2 1 N-terminal CTNNB1 binding HMG_box PF00505.19 EMC87173.1 - 1.4e-22 79.8 1.0 3.1e-22 78.8 1.0 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC87173.1 - 1.4e-08 35.2 2.0 3.1e-08 34.1 2.0 1.6 1 0 0 1 1 1 1 HMG-box domain 7tm_1 PF00001.21 EMC87174.1 - 9.9e-49 166.0 19.8 1.2e-48 165.8 19.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC87174.1 - 1e-16 61.1 17.5 1.3e-16 60.8 17.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC87174.1 - 8e-07 28.9 16.7 1.5e-06 28.1 16.7 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC87174.1 - 7.2e-05 22.7 12.0 8.8e-05 22.4 12.0 1.1 1 0 0 1 1 1 1 Olfactory receptor RhoGAP PF00620.27 EMC87175.1 - 5.2e-32 110.8 0.2 1.2e-31 109.6 0.2 1.6 1 1 0 1 1 1 1 RhoGAP domain RhoGAP PF00620.27 EMC87176.1 - 0.0039 17.0 0.1 0.0074 16.1 0.1 1.4 1 0 0 1 1 1 1 RhoGAP domain Gal-bind_lectin PF00337.22 EMC87177.1 - 1.6e-25 89.1 0.0 1.8e-25 89.0 0.0 1.0 1 0 0 1 1 1 1 Galactoside-binding lectin SERTA PF06031.13 EMC87178.1 - 3.5e-17 61.8 0.8 5.4e-17 61.2 0.8 1.3 1 0 0 1 1 1 1 SERTA motif SDF PF00375.18 EMC87179.1 - 1.2e-96 324.2 17.5 1.3e-96 324.0 17.5 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family VMA21 PF09446.10 EMC87179.1 - 0.23 11.6 2.5 1.3 9.2 2.5 2.4 1 1 0 1 1 1 0 VMA21-like domain Ras PF00071.22 EMC87180.1 - 1.8e-67 226.0 1.1 2.2e-67 225.7 1.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC87180.1 - 8.6e-38 129.2 0.1 1.6e-37 128.4 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC87180.1 - 2e-17 63.2 0.2 2.4e-17 62.9 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EMC87180.1 - 6.6e-07 29.4 0.5 0.011 15.6 0.1 2.4 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EMC87180.1 - 6.5e-06 25.8 0.3 1.8e-05 24.3 0.2 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EMC87180.1 - 7.1e-06 25.5 0.1 9.6e-06 25.1 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMC87180.1 - 8.1e-06 25.9 0.1 2.7e-05 24.2 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 EMC87180.1 - 1.4e-05 24.6 0.1 2.1e-05 24.0 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA PF00004.29 EMC87180.1 - 0.00084 19.8 0.0 0.12 12.8 0.0 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) FeoB_N PF02421.18 EMC87180.1 - 0.0034 16.9 0.0 0.018 14.6 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.6 EMC87180.1 - 0.017 15.5 0.0 0.023 15.1 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 EMC87180.1 - 0.019 14.7 0.1 0.95 9.2 0.0 2.3 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 EMC87180.1 - 0.044 13.3 0.1 0.19 11.3 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_22 PF13401.6 EMC87180.1 - 0.044 14.0 0.0 0.084 13.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EMC87180.1 - 0.055 14.0 0.0 0.079 13.5 0.0 1.6 1 1 0 1 1 1 0 ABC transporter Septin PF00735.18 EMC87180.1 - 0.061 12.6 0.1 0.13 11.5 0.0 1.6 1 1 0 1 1 1 0 Septin AAA_5 PF07728.14 EMC87180.1 - 0.065 13.2 0.0 0.087 12.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) LANC_like PF05147.13 EMC87180.1 - 0.074 11.6 0.1 0.16 10.5 0.0 1.5 1 1 1 2 2 2 0 Lanthionine synthetase C-like protein AAA_29 PF13555.6 EMC87180.1 - 0.074 12.8 0.2 0.18 11.5 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.11 EMC87180.1 - 0.14 11.5 0.0 0.32 10.4 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein Dioxygenase_N PF04444.14 EMC87180.1 - 0.16 11.8 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 Catechol dioxygenase N terminus Actin PF00022.19 EMC87181.1 - 1.5e-112 376.2 0.0 1.2e-111 373.2 0.0 1.9 1 1 0 1 1 1 1 Actin Sprouty PF05210.13 EMC87182.1 - 3e-29 101.4 25.8 3e-29 101.4 25.8 1.8 2 0 0 2 2 2 1 Sprouty protein (Spry) WH1 PF00568.23 EMC87182.1 - 2.2e-10 40.4 0.0 4e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 WH1 domain Homeobox_KN PF05920.11 EMC87184.1 - 7.6e-17 60.9 0.2 1.2e-16 60.3 0.2 1.3 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EMC87184.1 - 1.4e-07 31.3 0.1 2e-07 30.7 0.1 1.2 1 0 0 1 1 1 1 Homeodomain PRCH PF03967.13 EMC87184.1 - 0.27 11.5 2.1 0.3 11.3 0.0 2.1 1 1 2 3 3 3 0 Photosynthetic reaction centre, H-chain N-terminal region ETAA1 PF15350.6 EMC87185.1 - 3.2e-243 809.8 36.3 5.7e-149 498.0 4.7 2.0 1 1 1 2 2 2 2 Ewing's tumour-associated antigen 1 homologue Sas10_Utp3 PF04000.15 EMC87186.1 - 6.5e-17 61.9 0.4 1.1e-16 61.2 0.4 1.3 1 0 0 1 1 1 1 Sas10/Utp3/C1D family DUF932 PF06067.11 EMC87186.1 - 0.026 14.3 0.7 0.034 13.9 0.2 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF932) DUF5344 PF17279.2 EMC87186.1 - 0.053 14.1 0.7 8.5 7.0 0.1 2.6 2 1 1 3 3 3 0 Family of unknown function (DUF5344) ING PF12998.7 EMC87186.1 - 0.13 12.9 1.0 0.75 10.4 1.0 2.0 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding WD40 PF00400.32 EMC87187.1 - 4.9e-13 49.3 3.4 0.00018 22.2 0.0 5.6 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC87187.1 - 0.00079 19.7 0.1 0.95 9.8 0.0 2.9 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Itfg2 PF15907.5 EMC87187.1 - 0.0038 16.3 0.3 0.069 12.2 0.0 2.4 1 1 1 2 2 2 1 Integrin-alpha FG-GAP repeat-containing protein 2 BBS2_Mid PF14783.6 EMC87187.1 - 0.01 15.9 0.1 0.27 11.3 0.0 2.7 2 1 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region eIF2A PF08662.11 EMC87187.1 - 0.019 14.8 0.0 7 6.5 0.0 3.0 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A PHTB1_N PF14727.6 EMC87187.1 - 0.099 12.0 0.0 11 5.3 0.0 2.7 2 1 1 3 3 3 0 PTHB1 N-terminus KH_8 PF17903.1 EMC87188.1 - 4.4e-05 23.5 0.1 7.6e-05 22.7 0.1 1.3 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EMC87188.1 - 0.00016 21.4 0.9 0.00038 20.2 0.9 1.6 1 0 0 1 1 1 1 KH domain EF-hand_1 PF00036.32 EMC87189.1 - 2.2e-28 95.6 13.2 1.4e-06 27.4 0.4 4.9 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 EMC87189.1 - 2.4e-26 92.0 4.4 1.2e-14 54.5 0.3 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EMC87189.1 - 2.2e-22 77.5 8.3 1.9e-05 24.0 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EMC87189.1 - 5.2e-22 75.8 7.5 1.5e-05 24.5 0.2 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EMC87189.1 - 3.5e-19 68.4 6.8 0.001 18.9 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EMC87189.1 - 7.8e-09 35.8 0.1 0.0018 18.6 0.0 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EMC87189.1 - 1.5e-07 31.3 4.7 0.0041 17.1 0.3 3.7 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EMC87189.1 - 0.00039 20.7 0.3 0.043 14.2 0.0 2.7 2 1 1 3 3 3 1 EF-hand domain Caleosin PF05042.13 EMC87189.1 - 0.036 14.0 3.2 12 5.8 0.1 3.5 2 2 2 4 4 4 0 Caleosin related protein Dockerin_1 PF00404.18 EMC87189.1 - 8.7 6.6 9.4 12 6.2 2.7 3.3 2 2 0 2 2 2 0 Dockerin type I domain RhoGAP PF00620.27 EMC87190.1 - 0.0029 17.4 0.0 0.0048 16.7 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain MFS_1 PF07690.16 EMC87191.1 - 1.5e-42 145.8 29.3 6.4e-36 124.0 29.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EMC87191.1 - 1.8e-06 27.5 6.4 1.8e-06 27.5 6.4 2.1 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB MFS_1_like PF12832.7 EMC87191.1 - 1.2e-05 24.3 10.8 0.017 14.0 0.1 3.4 2 1 0 3 3 3 3 MFS_1 like family Sugar_tr PF00083.24 EMC87191.1 - 0.0017 17.3 9.4 0.0017 17.3 9.4 3.2 2 1 0 3 3 3 1 Sugar (and other) transporter DUF2140 PF09911.9 EMC87191.1 - 0.14 11.7 0.0 0.65 9.5 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) DUF202 PF02656.15 EMC87191.1 - 0.31 11.5 2.1 1 9.9 0.1 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF202) Pardaxin PF07425.11 EMC87191.1 - 1.8 8.2 4.9 0.31 10.7 0.6 2.0 2 0 0 2 2 2 0 Pardaxin TAFA PF12020.8 EMC87192.1 - 1.4e-32 112.0 9.0 1.9e-32 111.6 9.0 1.2 1 0 0 1 1 1 1 TAFA family UCH PF00443.29 EMC87193.1 - 5.2e-84 281.8 0.1 7.6e-84 281.2 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_3 PF14836.6 EMC87193.1 - 2.7e-40 136.3 0.1 5.6e-40 135.2 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain DUSP PF06337.12 EMC87193.1 - 7.2e-22 77.8 1.3 7.2e-22 77.8 1.3 2.3 2 0 0 2 2 2 1 DUSP domain UCH_1 PF13423.6 EMC87193.1 - 5e-15 55.9 0.0 3.4e-08 33.5 0.0 3.5 2 1 0 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 EMC87193.1 - 4.7e-10 39.5 0.6 1.8e-08 34.4 0.0 2.9 3 0 0 3 3 3 1 Ubiquitin-specific protease C-terminal USP7_ICP0_bdg PF12436.8 EMC87193.1 - 0.00034 20.0 0.0 0.00093 18.6 0.0 1.6 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 CW_binding_1 PF01473.20 EMC87193.1 - 0.36 11.2 8.0 0.33 11.4 4.7 2.7 2 0 0 2 2 2 0 Putative cell wall binding repeat Mon2_C PF16206.5 EMC87194.1 - 0 1342.8 5.0 0 1341.7 3.9 1.8 2 0 0 2 2 2 1 C-terminal region of Mon2 protein Sec7_N PF12783.7 EMC87194.1 - 9.5e-43 145.8 4.7 1.2e-42 145.6 2.4 2.5 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 EMC87194.1 - 3.4e-18 65.3 0.4 7.3e-16 57.8 0.0 4.0 3 0 0 3 3 3 1 Domain of unknown function (DUF1981) HEAT PF02985.22 EMC87194.1 - 3.2e-05 23.8 1.3 12 6.5 0.0 5.3 4 0 0 4 4 4 2 HEAT repeat Keratin_assoc PF09775.9 EMC87194.1 - 0.013 15.1 0.1 0.57 9.8 0.1 2.7 2 0 0 2 2 2 0 Keratinocyte-associated protein 2 SelK_SelG PF10961.8 EMC87194.1 - 0.86 10.3 3.0 0.75 10.4 0.7 2.1 2 0 0 2 2 2 0 Selenoprotein SelK_SelG Cullin PF00888.22 EMC87195.1 - 2e-13 49.9 0.0 2.1e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 Cullin family Herpes_pp85 PF04637.12 EMC87195.1 - 0.0045 15.5 0.0 0.0066 14.9 0.0 1.3 1 0 0 1 1 1 1 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) DNA_repr_REX1B PF14966.6 EMC87195.1 - 0.027 15.1 0.1 0.059 14.0 0.1 1.6 1 0 0 1 1 1 0 DNA repair REX1-B DUF4853 PF16145.5 EMC87195.1 - 0.13 12.4 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4853) PCI PF01399.27 EMC87196.1 - 4.1e-18 65.8 0.1 4.1e-18 65.8 0.1 2.7 3 0 0 3 3 3 1 PCI domain Gag_p30 PF02093.16 EMC87197.1 - 2.2e-20 73.1 0.1 2.5e-20 72.9 0.1 1.0 1 0 0 1 1 1 1 Gag P30 core shell protein PHP PF02811.19 EMC87197.1 - 0.08 13.2 0.0 0.085 13.1 0.0 1.1 1 0 0 1 1 1 0 PHP domain C1-set PF07654.15 EMC87198.1 - 0.0016 18.8 0.5 0.013 15.8 0.5 2.1 1 1 0 1 1 1 1 Immunoglobulin C1-set domain DUF1968 PF09291.10 EMC87198.1 - 0.0018 18.3 0.3 0.0039 17.2 0.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1968) Trypsin PF00089.26 EMC87199.1 - 3.7e-58 196.9 0.2 4.2e-58 196.8 0.2 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EMC87199.1 - 3.3e-06 28.1 0.0 4.9e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain Ion_trans_N PF08412.10 EMC87199.1 - 0.037 13.6 0.2 0.98 9.1 0.1 2.4 2 0 0 2 2 2 0 Ion transport protein N-terminal VIT PF08487.10 EMC87200.1 - 9.5e-22 77.3 0.0 1.5e-21 76.6 0.0 1.4 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 EMC87200.1 - 7.1e-11 42.3 0.0 1.5e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.6 EMC87200.1 - 5.9e-06 26.1 0.5 1.5e-05 24.8 0.5 1.7 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain 7tm_4 PF13853.6 EMC87201.1 - 4.7e-48 164.3 23.8 5.8e-48 164.0 23.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC87201.1 - 2.1e-22 79.7 25.6 3.2e-22 79.1 25.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC87202.1 - 5.5e-48 164.1 23.7 6.5e-48 163.9 23.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC87202.1 - 6.8e-26 91.2 22.3 9.8e-26 90.6 22.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC87202.1 - 6.9e-07 28.9 24.2 1.7e-06 27.6 24.2 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Trypsin PF00089.26 EMC87203.1 - 3.7e-58 196.9 0.2 4.2e-58 196.8 0.2 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EMC87203.1 - 3.3e-06 28.1 0.0 4.9e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain Ion_trans_N PF08412.10 EMC87203.1 - 0.037 13.6 0.2 0.98 9.1 0.1 2.4 2 0 0 2 2 2 0 Ion transport protein N-terminal DUF1731 PF08338.11 EMC87204.1 - 6e-19 67.6 0.1 1.3e-18 66.5 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1731) 7tm_4 PF13853.6 EMC87205.1 - 5e-49 167.5 19.0 5.9e-49 167.3 19.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC87205.1 - 1.1e-23 83.9 22.7 1.5e-23 83.5 22.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC87205.1 - 1.9e-05 24.2 26.6 3.8e-05 23.2 26.6 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC87205.1 - 0.05 13.2 30.0 0.13 11.9 30.0 1.7 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC87206.1 - 2.6e-47 161.9 28.0 3.4e-47 161.5 28.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC87206.1 - 2.2e-26 92.7 28.2 3e-26 92.3 28.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC87206.1 - 0.0084 15.5 29.9 0.012 15.0 29.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC87206.1 - 0.12 12.0 32.0 0.46 10.1 32.0 2.0 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC87208.1 - 8.3e-51 173.4 28.2 9.9e-51 173.1 28.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC87208.1 - 3.2e-24 85.7 29.9 4.6e-24 85.2 29.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) ATP-synt_8 PF00895.20 EMC87208.1 - 0.029 14.8 0.6 0.029 14.8 0.6 4.4 3 2 1 4 4 4 0 ATP synthase protein 8 7tm_4 PF13853.6 EMC87209.1 - 1.5e-49 169.2 19.1 1.9e-49 168.9 19.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC87209.1 - 8.7e-31 107.2 22.1 1.2e-30 106.7 22.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Sterol_MT_C PF08498.10 EMC87209.1 - 0.058 13.7 0.0 0.16 12.3 0.0 1.8 1 0 0 1 1 1 0 Sterol methyltransferase C-terminal 7TM_GPCR_Srsx PF10320.9 EMC87209.1 - 5.9 6.2 28.4 68 2.7 27.7 2.3 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx CPCFC PF17223.3 EMC87211.1 - 0.17 11.6 0.9 0.17 11.6 0.9 4.8 5 0 0 5 5 5 0 Cuticle protein CPCFC BRICHOS PF04089.14 EMC87214.1 - 5.2e-15 55.5 0.0 1e-14 54.5 0.0 1.4 1 0 0 1 1 1 1 BRICHOS domain BRICHOS PF04089.14 EMC87215.1 - 1.4e-22 79.8 0.0 1.6e-22 79.6 0.0 1.1 1 0 0 1 1 1 1 BRICHOS domain TGF_beta PF00019.20 EMC87216.1 - 5.6e-30 104.4 0.6 9.4e-30 103.7 0.6 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 EMC87216.1 - 4.2e-23 82.3 0.5 3.8e-22 79.2 0.5 2.0 1 1 0 1 1 1 1 TGF-beta propeptide RhoGAP PF00620.27 EMC87217.1 - 3.5e-44 150.3 0.8 1e-42 145.5 0.0 2.3 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.29 EMC87217.1 - 5.6e-23 81.5 0.6 1.8e-22 79.9 0.0 2.1 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 EMC87217.1 - 7.8e-06 26.3 0.4 0.00036 20.9 0.1 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 EMC87217.1 - 1.8e-05 25.0 0.7 0.00042 20.5 0.7 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain Nsp1_C PF05064.13 EMC87217.1 - 0.011 15.6 12.5 0.025 14.4 12.0 1.9 2 0 0 2 2 2 0 Nsp1-like C-terminal region Cnn_1N PF07989.11 EMC87217.1 - 0.034 14.3 15.7 0.043 14.0 13.5 2.2 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 PH_9 PF15410.6 EMC87217.1 - 0.035 14.5 2.1 0.43 11.0 0.0 3.0 3 0 0 3 3 3 0 Pleckstrin homology domain CENP-F_leu_zip PF10473.9 EMC87217.1 - 0.22 11.6 20.9 0.41 10.7 20.9 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ADIP PF11559.8 EMC87217.1 - 0.52 10.4 14.2 1.2 9.2 14.2 1.6 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding FlaC_arch PF05377.11 EMC87217.1 - 1.2 9.6 13.0 7.2 7.1 4.8 2.6 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) APG6_N PF17675.1 EMC87217.1 - 3.1 8.3 18.2 7.2 7.1 18.2 1.7 1 0 0 1 1 1 0 Apg6 coiled-coil region Jnk-SapK_ap_N PF09744.9 EMC87217.1 - 3.1 8.0 20.1 15 5.7 16.0 2.4 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Exonuc_VII_L PF02601.15 EMC87217.1 - 9.6 5.7 7.2 16 5.0 7.2 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit CTP_transf_1 PF01148.20 EMC87218.1 - 3.2e-87 292.7 21.3 3.9e-87 292.4 21.3 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family PCNA_C PF02747.15 EMC87219.1 - 8.1e-64 213.6 0.1 1.5e-63 212.7 0.0 1.5 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain PCNA_N PF00705.18 EMC87219.1 - 4.3e-52 175.1 0.1 1.7e-51 173.2 0.1 1.9 1 1 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain Rad1 PF02144.16 EMC87219.1 - 1.8e-06 27.3 0.0 0.00015 21.0 0.0 2.1 1 1 1 2 2 2 2 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.13 EMC87219.1 - 0.0005 19.6 0.0 0.0025 17.3 0.0 2.2 1 1 0 1 1 1 1 Rad9 DUF872 PF05915.12 EMC87220.1 - 4.7e-21 75.1 0.4 5.2e-21 74.9 0.4 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF872) Neurensin PF14927.6 EMC87220.1 - 0.0043 16.8 0.7 0.14 11.9 0.7 2.0 1 1 0 1 1 1 1 Neurensin DUF2207 PF09972.9 EMC87220.1 - 0.0088 14.9 0.6 0.01 14.7 0.6 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF3040 PF11239.8 EMC87220.1 - 0.05 13.9 0.1 0.069 13.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) DUF308 PF03729.13 EMC87220.1 - 0.18 12.1 11.2 0.79 10.1 9.6 2.0 1 1 1 2 2 2 0 Short repeat of unknown function (DUF308) Saf_2TM PF18303.1 EMC87220.1 - 1.4 8.5 4.4 1 8.9 0.6 2.0 1 1 0 2 2 2 0 SAVED-fused 2TM effector domain Xan_ur_permease PF00860.20 EMC87221.1 - 7.8e-91 304.7 21.1 1.1e-90 304.1 21.1 1.2 1 0 0 1 1 1 1 Permease family MFS_MOT1 PF16983.5 EMC87221.1 - 7.4 7.0 20.8 2.8 8.4 0.4 4.5 4 2 0 4 4 4 0 Molybdate transporter of MFS superfamily Prion PF00377.18 EMC87224.1 - 1e-44 151.1 0.0 1.5e-44 150.6 0.0 1.2 1 0 0 1 1 1 1 Prion/Doppel alpha-helical domain SNARE_assoc PF09335.11 EMC87224.1 - 0.11 13.0 0.0 0.18 12.3 0.0 1.3 1 0 0 1 1 1 0 SNARE associated Golgi protein DUF2076 PF09849.9 EMC87224.1 - 0.57 10.2 4.6 0.63 10.0 4.6 1.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Prominin PF05478.11 EMC87225.1 - 6e-132 441.3 0.0 6.6e-132 441.1 0.0 1.0 1 0 0 1 1 1 1 Prominin Phage_CP76 PF06892.11 EMC87225.1 - 0.18 11.4 0.7 0.3 10.6 0.7 1.3 1 0 0 1 1 1 0 Phage regulatory protein CII (CP76) DSPc PF00782.20 EMC87226.1 - 1.5e-15 57.2 0.0 1.9e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DSPn PF14671.6 EMC87226.1 - 0.0022 18.4 0.0 0.0044 17.5 0.0 1.6 1 1 0 1 1 1 1 Dual specificity protein phosphatase, N-terminal half Y_phosphatase3 PF13350.6 EMC87226.1 - 0.011 15.7 0.2 0.018 15.0 0.2 1.3 1 1 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 EMC87226.1 - 0.013 15.1 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase USP8_dimer PF08969.11 EMC87227.1 - 8.9e-21 74.2 0.5 8.9e-21 74.2 0.5 1.9 1 1 0 1 1 1 1 USP8 dimerisation domain JAB PF01398.21 EMC87227.1 - 1.2e-20 73.7 0.1 1.2e-20 73.7 0.1 1.9 2 1 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 EMC87227.1 - 2.6e-07 30.4 0.9 1e-06 28.5 0.0 2.2 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain Actin PF00022.19 EMC87228.1 - 2.7e-116 388.5 0.0 1e-115 386.6 0.0 1.7 1 1 0 1 1 1 1 Actin dNK PF01712.19 EMC87229.1 - 1.5e-56 191.5 0.0 1.7e-56 191.3 0.0 1.0 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.6 EMC87229.1 - 0.0067 17.0 1.1 0.25 11.9 0.1 2.9 2 1 1 3 3 3 1 AAA domain AAA_33 PF13671.6 EMC87229.1 - 0.048 13.8 0.0 2.2 8.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.17 EMC87229.1 - 0.11 12.2 0.0 0.41 10.3 0.0 1.9 2 0 0 2 2 2 0 Thymidylate kinase BolA PF01722.18 EMC87230.1 - 3.9e-12 46.3 0.1 4.3e-12 46.1 0.1 1.3 1 1 0 1 1 1 1 BolA-like protein Glucokinase PF02685.16 EMC87230.1 - 0.014 14.4 0.1 0.016 14.2 0.1 1.0 1 0 0 1 1 1 0 Glucokinase THF_DHG_CYH PF00763.23 EMC87231.1 - 7.8e-35 119.6 0.0 8.8e-35 119.5 0.0 1.0 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 EMC87231.1 - 0.00018 20.9 0.0 0.00034 19.9 0.0 1.5 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain HCO3_cotransp PF00955.21 EMC87232.1 - 4e-228 758.3 8.4 5e-228 758.0 8.4 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 EMC87232.1 - 1.2e-63 215.5 0.0 1.7e-63 214.9 0.0 1.2 1 0 0 1 1 1 1 Band 3 cytoplasmic domain Xan_ur_permease PF00860.20 EMC87232.1 - 0.0046 15.7 8.0 0.047 12.4 0.9 2.6 2 0 0 2 2 2 2 Permease family Tetraspanin PF00335.20 EMC87233.1 - 7.1e-48 163.3 7.5 8.4e-48 163.1 7.5 1.1 1 0 0 1 1 1 1 Tetraspanin family ABC2_membrane_3 PF12698.7 EMC87233.1 - 2.9 6.9 11.4 2.4 7.2 9.4 1.7 2 0 0 2 2 2 0 ABC-2 family transporter protein DUF2371 PF10177.9 EMC87233.1 - 3.2 7.9 5.3 15 5.7 0.9 2.8 2 1 1 3 3 3 0 Uncharacterised conserved protein (DUF2371) 7tm_1 PF00001.21 EMC87234.1 - 8.6e-31 107.2 10.9 1.1e-30 106.9 10.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC87234.1 - 0.0013 18.1 3.9 0.0017 17.8 3.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF1345 PF07077.11 EMC87234.1 - 0.053 13.2 2.2 0.075 12.7 1.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1345) TctB PF07331.11 EMC87234.1 - 0.17 12.2 2.3 0.46 10.7 2.3 1.7 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family Cnd2 PF05786.14 EMC87235.1 - 2.4e-15 56.3 0.0 2.5e-15 56.3 0.0 1.0 1 0 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 EMC87235.1 - 0.068 13.4 0.0 0.068 13.4 0.0 1.0 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Cnd2 PF05786.14 EMC87236.1 - 2.1e-69 235.1 0.2 2.5e-69 234.8 0.2 1.0 1 0 0 1 1 1 1 Condensin complex subunit 2 Pkinase PF00069.25 EMC87237.1 - 7.6e-64 215.6 0.0 3.3e-63 213.5 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87237.1 - 5.2e-43 147.2 0.0 5.2e-43 147.2 0.0 2.1 2 1 0 2 2 2 1 Protein tyrosine kinase PKK PF12474.8 EMC87237.1 - 4.3e-24 85.2 92.5 8e-17 61.7 40.1 5.0 2 2 2 4 4 4 2 Polo kinase kinase Spore_YtrH PF14034.6 EMC87237.1 - 0.18 11.9 0.0 0.39 10.9 0.0 1.5 1 0 0 1 1 1 0 Sporulation protein YtrH DUF348 PF03990.14 EMC87237.1 - 5.3 6.9 5.1 1.1 9.0 1.0 2.1 2 0 0 2 2 2 0 G5-linked-Ubiquitin-like domain ARID PF01388.21 EMC87238.1 - 1.2e-13 51.5 0.0 1.2e-13 51.5 0.0 1.0 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain DLH PF01738.18 EMC87239.1 - 0.1 12.2 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family PRY PF13765.6 EMC87242.1 - 1.7e-19 69.1 0.1 2.1e-19 68.8 0.1 1.1 1 0 0 1 1 1 1 SPRY-associated domain 7tm_4 PF13853.6 EMC87244.1 - 4.1e-13 49.7 0.2 4.5e-13 49.6 0.2 1.0 1 0 0 1 1 1 1 Olfactory receptor Cast PF10174.9 EMC87246.1 - 7.2e-05 21.2 11.2 8.3e-05 21.0 11.2 1.2 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone KASH_CCD PF14662.6 EMC87246.1 - 0.00012 22.0 16.0 0.00016 21.6 16.0 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH bZIP_1 PF00170.21 EMC87246.1 - 0.00057 19.9 17.5 0.0046 17.0 0.4 3.5 2 1 0 3 3 3 2 bZIP transcription factor Prominin PF05478.11 EMC87246.1 - 0.0015 16.6 1.2 0.0016 16.5 1.2 1.1 1 0 0 1 1 1 1 Prominin HAUS-augmin3 PF14932.6 EMC87246.1 - 0.0017 18.0 9.3 0.0024 17.5 9.3 1.2 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 DUF4200 PF13863.6 EMC87246.1 - 0.0027 18.1 19.0 0.024 15.1 19.0 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4200) Fmp27_WPPW PF10359.9 EMC87246.1 - 0.0031 16.4 8.1 0.0037 16.2 8.1 1.2 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF4686 PF15742.5 EMC87246.1 - 0.0097 15.1 17.6 0.014 14.5 17.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4686) DHR10 PF18595.1 EMC87246.1 - 0.017 15.1 15.1 0.017 15.1 15.1 2.2 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain Spc7 PF08317.11 EMC87246.1 - 0.018 14.0 15.0 0.023 13.6 15.0 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein HSD3 PF15244.6 EMC87246.1 - 0.024 14.2 4.6 0.031 13.8 4.6 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 DUF2937 PF11157.8 EMC87246.1 - 0.033 13.9 5.0 0.053 13.2 5.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) Exonuc_VII_L PF02601.15 EMC87246.1 - 0.039 13.5 8.5 0.042 13.4 8.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit SlyX PF04102.12 EMC87246.1 - 0.04 14.5 6.2 0.04 14.5 6.2 3.2 1 1 2 3 3 3 0 SlyX SpoIISA_toxin PF14171.6 EMC87246.1 - 0.052 13.2 1.0 0.07 12.8 1.0 1.2 1 0 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system Jnk-SapK_ap_N PF09744.9 EMC87246.1 - 0.06 13.6 18.3 1.9 8.7 2.9 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 MPS2 PF17060.5 EMC87246.1 - 0.068 12.4 7.3 0.074 12.3 7.3 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 DUF4407 PF14362.6 EMC87246.1 - 0.078 12.3 7.4 0.089 12.1 7.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4988 PF16378.5 EMC87246.1 - 0.085 12.5 3.5 2.6 7.7 0.8 2.2 1 1 1 2 2 2 0 Domain of unknown function VirC1 PF07015.11 EMC87246.1 - 0.089 12.1 0.3 0.11 11.7 0.3 1.1 1 0 0 1 1 1 0 VirC1 protein Aminopep PF10023.9 EMC87246.1 - 0.091 12.1 4.1 0.11 11.9 4.1 1.1 1 0 0 1 1 1 0 Putative aminopeptidase bZIP_2 PF07716.15 EMC87246.1 - 0.099 12.7 0.9 0.099 12.7 0.9 3.7 3 2 0 3 3 2 0 Basic region leucine zipper Bacillus_HBL PF05791.11 EMC87246.1 - 0.11 12.3 4.7 0.29 10.9 3.5 2.1 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Tropomyosin_1 PF12718.7 EMC87246.1 - 0.13 12.5 17.3 0.068 13.3 14.7 1.7 1 1 0 1 1 1 0 Tropomyosin like CALCOCO1 PF07888.11 EMC87246.1 - 0.15 10.9 17.9 0.19 10.5 17.9 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like FapA PF03961.13 EMC87246.1 - 0.19 10.3 7.4 0.24 10.0 7.4 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF1664 PF07889.12 EMC87246.1 - 0.2 11.7 9.4 0.48 10.5 7.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ADIP PF11559.8 EMC87246.1 - 0.2 11.7 16.8 1 9.5 12.6 2.6 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding CLZ PF16526.5 EMC87246.1 - 0.28 11.6 18.4 16 5.9 14.3 3.2 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels HOOK PF05622.12 EMC87246.1 - 0.29 9.2 16.6 0.33 9.1 16.6 1.0 1 0 0 1 1 1 0 HOOK protein AAA_32 PF13654.6 EMC87246.1 - 0.3 9.8 8.9 0.37 9.5 8.9 1.1 1 0 0 1 1 1 0 AAA domain DUF724 PF05266.14 EMC87246.1 - 0.31 10.9 12.6 0.42 10.4 12.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) CENP-F_leu_zip PF10473.9 EMC87246.1 - 0.33 11.0 20.5 2 8.4 17.0 2.0 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fib_alpha PF08702.10 EMC87246.1 - 0.37 11.0 10.3 0.39 10.9 8.1 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family AAA_13 PF13166.6 EMC87246.1 - 0.49 9.0 8.1 0.57 8.8 8.1 1.1 1 0 0 1 1 1 0 AAA domain Prefoldin_2 PF01920.20 EMC87246.1 - 0.63 10.0 17.6 0.45 10.5 3.7 3.1 1 1 1 3 3 3 0 Prefoldin subunit AKNA PF12443.8 EMC87246.1 - 0.66 10.7 6.9 1.1 9.9 5.4 2.1 1 1 1 2 2 2 0 AT-hook-containing transcription factor ATG16 PF08614.11 EMC87246.1 - 0.7 10.1 19.5 0.24 11.6 10.8 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF16 PF01519.16 EMC87246.1 - 0.71 10.4 11.4 0.88 10.1 6.3 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 Occludin_ELL PF07303.13 EMC87246.1 - 0.73 10.6 7.4 0.48 11.2 5.3 1.8 1 1 1 2 2 2 0 Occludin homology domain V_ATPase_I PF01496.19 EMC87246.1 - 0.76 7.6 8.5 0.87 7.4 8.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cnn_1N PF07989.11 EMC87246.1 - 0.82 9.9 14.3 0.29 11.3 8.7 2.5 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 Atg14 PF10186.9 EMC87246.1 - 0.82 8.7 15.7 1.4 7.9 15.7 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CCDC-167 PF15188.6 EMC87246.1 - 0.98 9.8 16.6 0.74 10.2 2.9 3.0 1 1 1 3 3 3 0 Coiled-coil domain-containing protein 167 DUF848 PF05852.11 EMC87246.1 - 1.1 9.4 12.2 0.31 11.2 3.5 2.1 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) CorA PF01544.18 EMC87246.1 - 1.1 8.5 6.2 1.5 8.0 6.2 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein BLOC1_2 PF10046.9 EMC87246.1 - 1.1 9.6 10.7 0.87 9.9 2.1 2.8 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF948 PF06103.11 EMC87246.1 - 1.1 9.5 3.7 2 8.7 2.8 1.7 1 1 1 2 2 1 0 Bacterial protein of unknown function (DUF948) FAM76 PF16046.5 EMC87246.1 - 1.2 8.5 12.2 2.6 7.3 12.2 1.6 1 1 0 1 1 1 0 FAM76 protein DUF737 PF05300.11 EMC87246.1 - 1.2 9.5 14.7 1.6 9.0 14.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF737) DUF445 PF04286.12 EMC87246.1 - 1.2 8.9 9.2 1.4 8.7 9.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) TSC22 PF01166.18 EMC87246.1 - 1.2 9.5 9.4 7.6 6.9 0.6 3.4 1 1 2 3 3 3 0 TSC-22/dip/bun family Sec2p PF06428.11 EMC87246.1 - 1.3 9.1 15.3 0.23 11.4 3.4 3.2 1 1 1 3 3 3 0 GDP/GTP exchange factor Sec2p DUF4618 PF15397.6 EMC87246.1 - 1.3 8.4 15.8 3.8 6.8 0.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) Med9 PF07544.13 EMC87246.1 - 1.3 9.2 12.0 3.4 7.8 11.3 2.1 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 CREPT PF16566.5 EMC87246.1 - 1.4 9.0 12.0 2.2 8.4 12.0 1.3 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour DUF4795 PF16043.5 EMC87246.1 - 1.5 8.4 15.7 5.7 6.5 15.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Hemerythrin PF01814.23 EMC87246.1 - 1.7 9.3 10.7 3.4 8.3 1.3 2.3 1 1 1 2 2 2 0 Hemerythrin HHE cation binding domain ACCA PF03255.14 EMC87246.1 - 2.1 8.2 8.1 1.9 8.3 5.9 2.1 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit GrpE PF01025.19 EMC87246.1 - 2.2 8.0 14.3 0.96 9.1 3.9 2.7 1 1 2 3 3 3 0 GrpE YabA PF06156.13 EMC87246.1 - 2.2 9.0 14.3 0.64 10.7 3.7 2.7 1 1 1 2 2 2 0 Initiation control protein YabA Seryl_tRNA_N PF02403.22 EMC87246.1 - 2.2 8.5 13.4 0.9 9.8 7.8 2.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain E2F_CC-MB PF16421.5 EMC87246.1 - 2.4 8.6 8.3 1.4 9.3 5.8 2.1 2 1 0 2 2 1 0 E2F transcription factor CC-MB domain kleA_kleC PF17383.2 EMC87246.1 - 2.5 8.5 6.8 1.3 9.4 1.7 2.3 1 1 1 2 2 2 0 Uncharacterized KorC regulated protein A COG2 PF06148.11 EMC87246.1 - 2.7 8.1 8.9 1.6 8.8 5.7 2.1 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 TMF_DNA_bd PF12329.8 EMC87246.1 - 3.1 7.9 20.5 2.2 8.3 9.4 2.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding LMBR1 PF04791.16 EMC87246.1 - 3.3 6.5 4.2 3.7 6.4 4.2 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Spc29 PF17082.5 EMC87246.1 - 4.5 7.0 12.2 2.2 8.1 6.6 2.1 1 1 1 2 2 2 0 Spindle Pole Component 29 Val_tRNA-synt_C PF10458.9 EMC87246.1 - 4.8 7.5 10.4 2.2 8.6 3.0 3.1 1 1 2 3 3 3 0 Valyl tRNA synthetase tRNA binding arm DUF641 PF04859.12 EMC87246.1 - 5.1 7.5 14.0 10 6.5 7.9 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) UPF0242 PF06785.11 EMC87246.1 - 5.2 7.1 16.9 7 6.7 16.9 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF3450 PF11932.8 EMC87246.1 - 5.7 6.2 14.9 5.2 6.3 12.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Nas2_N PF18265.1 EMC87246.1 - 6.5 6.8 9.7 3.4 7.6 0.2 2.9 2 1 1 3 3 2 0 Nas2 N_terminal domain ZapB PF06005.12 EMC87246.1 - 6.9 7.2 21.6 2.9 8.4 5.2 3.1 1 1 1 2 2 2 0 Cell division protein ZapB PX PF00787.24 EMC87247.1 - 2.6e-19 69.3 0.1 4.5e-19 68.5 0.1 1.4 1 0 0 1 1 1 1 PX domain SNX17_FERM_C PF18116.1 EMC87247.1 - 0.00043 20.3 0.2 0.00093 19.3 0.2 1.6 1 0 0 1 1 1 1 Sorting Nexin 17 FERM C-terminal domain PDZ_6 PF17820.1 EMC87247.1 - 0.022 14.6 0.1 0.043 13.7 0.1 1.5 1 0 0 1 1 1 0 PDZ domain RRM_1 PF00076.22 EMC87248.1 - 0.00027 20.7 0.0 0.00048 19.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HNF-1B_C PF04812.13 EMC87248.1 - 0.0082 16.0 2.2 0.0097 15.8 2.2 1.2 1 0 0 1 1 1 1 Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus F5_F8_type_C PF00754.25 EMC87249.1 - 3.8e-10 40.0 0.0 4.2e-10 39.8 0.0 1.0 1 0 0 1 1 1 1 F5/8 type C domain Collagen PF01391.18 EMC87250.1 - 1.6e-18 66.2 103.7 0.0032 17.2 5.8 7.7 1 1 4 5 5 5 4 Collagen triple helix repeat (20 copies) Ribosomal_S14 PF00253.21 EMC87251.1 - 9.6e-11 41.3 0.9 1.1e-10 41.1 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e LRR_8 PF13855.6 EMC87252.1 - 6.5e-16 57.8 12.3 3e-07 30.1 1.2 3.4 3 0 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EMC87252.1 - 3e-15 56.1 11.5 1.7e-06 28.3 0.8 4.5 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC87252.1 - 0.0065 16.9 18.6 0.43 11.3 0.0 7.1 6 1 0 6 6 6 1 Leucine Rich Repeat LRR_6 PF13516.6 EMC87252.1 - 0.075 13.1 12.5 0.4 10.9 0.2 4.8 5 0 0 5 5 5 0 Leucine Rich repeat DNA_pol_E_B PF04042.16 EMC87254.1 - 1.9e-52 177.7 1.0 3.2e-52 176.9 1.0 1.4 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Dpoe2NT PF12213.8 EMC87254.1 - 6e-18 64.9 0.3 1.3e-17 63.9 0.3 1.6 1 0 0 1 1 1 1 DNA polymerases epsilon N terminal Kelch_4 PF13418.6 EMC87255.1 - 1.4e-26 92.2 19.8 1.8e-07 31.1 0.4 6.7 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 EMC87255.1 - 1.8e-24 85.4 17.1 4.2e-08 33.3 0.1 5.8 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EMC87255.1 - 6.4e-24 83.4 20.3 5.5e-06 26.5 0.3 6.8 3 2 3 6 6 6 4 Kelch motif Kelch_1 PF01344.25 EMC87255.1 - 1.6e-18 66.0 11.9 9.6e-06 25.1 0.1 5.8 6 0 0 6 6 6 4 Kelch motif Kelch_5 PF13854.6 EMC87255.1 - 2.3e-17 62.5 6.6 0.00082 19.3 0.1 6.3 6 1 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 EMC87255.1 - 5.9e-17 60.9 18.5 2.8e-06 27.1 0.0 6.1 5 2 1 6 6 6 5 Kelch motif Kelch_5 PF13854.6 EMC87256.1 - 4.7e-25 87.1 15.9 1.5e-05 24.9 0.1 7.6 7 2 0 7 7 7 6 Kelch motif Kelch_4 PF13418.6 EMC87256.1 - 1.4e-24 85.9 22.3 2.7e-09 36.9 0.1 7.7 5 2 2 7 7 7 5 Galactose oxidase, central domain Kelch_1 PF01344.25 EMC87256.1 - 1.3e-23 82.3 15.3 3.4e-06 26.5 0.1 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 EMC87256.1 - 1.3e-19 69.9 15.2 2.2e-06 27.8 0.3 7.4 7 2 0 7 7 7 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EMC87256.1 - 4.5e-18 64.8 13.2 2.2e-05 24.6 0.0 6.6 6 1 1 7 7 7 3 Kelch motif Kelch_2 PF07646.15 EMC87256.1 - 1.9e-14 52.9 19.3 0.00014 21.7 0.0 7.0 6 1 0 6 6 6 5 Kelch motif Arf PF00025.21 EMC87257.1 - 1.1e-78 262.7 0.1 1.2e-78 262.6 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EMC87257.1 - 3.4e-15 56.3 0.0 4.5e-15 55.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMC87257.1 - 2.2e-14 53.4 0.0 2.4e-14 53.3 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EMC87257.1 - 3.4e-13 49.4 0.0 4.2e-13 49.1 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EMC87257.1 - 1.7e-12 47.2 1.0 4.3e-08 32.7 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EMC87257.1 - 1.4e-10 40.9 0.0 1.8e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMC87257.1 - 0.00011 22.3 0.0 0.00015 21.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EMC87257.1 - 0.0053 16.1 0.2 0.0083 15.5 0.2 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase SpoOE-like PF09388.10 EMC87257.1 - 0.022 14.7 1.2 0.041 13.8 1.2 1.4 1 0 0 1 1 1 0 Spo0E like sporulation regulatory protein CRISPR_Cas2 PF09827.9 EMC87257.1 - 0.12 12.5 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 CRISPR associated protein Cas2 Methyltransf_16 PF10294.9 EMC87258.1 - 7.5e-29 100.7 0.0 8.8e-29 100.4 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EMC87258.1 - 0.029 14.2 0.0 0.029 14.2 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain RasGEF PF00617.19 EMC87259.1 - 6e-50 169.9 0.4 1.2e-49 168.9 0.4 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EMC87259.1 - 1.4e-31 108.8 1.0 6.8e-31 106.6 0.1 2.5 3 0 0 3 3 3 1 RasGEF N-terminal motif RhoGEF PF00621.20 EMC87259.1 - 2.2e-16 60.6 1.4 2.2e-16 60.6 1.4 2.7 3 1 0 3 3 3 1 RhoGEF domain PH PF00169.29 EMC87259.1 - 9.3e-11 42.2 0.3 6.8e-10 39.4 0.0 2.5 2 0 0 2 2 2 1 PH domain Histone PF00125.24 EMC87259.1 - 5.3e-10 39.8 0.0 1.2e-09 38.7 0.0 1.6 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 IQ_SEC7_PH PF16453.5 EMC87259.1 - 0.00053 20.0 0.0 0.0016 18.4 0.0 1.8 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 EMC87259.1 - 0.025 14.4 0.0 0.088 12.6 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain PH_10 PF15411.6 EMC87259.1 - 0.027 14.7 0.0 0.11 12.8 0.0 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain PH_9 PF15410.6 EMC87259.1 - 0.13 12.7 0.1 0.54 10.6 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain DAO PF01266.24 EMC87260.1 - 3.7e-51 174.8 0.0 4.9e-51 174.4 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase LRR_4 PF12799.7 EMC87261.1 - 0.27 11.7 2.1 0.69 10.4 0.1 2.6 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) Pkinase PF00069.25 EMC87262.1 - 3.8e-74 249.4 0.0 4.5e-74 249.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87262.1 - 1.7e-31 109.5 0.0 1.3e-30 106.6 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EMC87262.1 - 4.5e-05 22.6 0.2 5.5e-05 22.3 0.2 1.3 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EMC87262.1 - 0.03 14.2 0.4 0.12 12.2 0.2 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EMC87262.1 - 0.16 11.0 0.1 0.26 10.3 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 GBP PF02263.19 EMC87263.1 - 1.8e-89 299.4 0.0 2.5e-89 299.0 0.0 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.14 EMC87263.1 - 4.1e-06 26.4 0.1 6.3e-06 25.8 0.1 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain Tiam_CC_Ex PF18385.1 EMC87263.1 - 0.007 16.7 0.0 0.027 14.8 0.0 2.0 1 0 0 1 1 1 1 T-lymphoma invasion and metastasis CC-Ex domain FA_desaturase PF00487.24 EMC87263.1 - 0.019 14.8 0.1 0.04 13.8 0.1 1.5 1 0 0 1 1 1 0 Fatty acid desaturase WW PF00397.26 EMC87264.1 - 5.7e-16 58.3 14.1 4.9e-10 39.3 4.3 3.5 3 0 0 3 3 3 2 WW domain Suppressor_APC PF11414.8 EMC87264.1 - 0.44 10.6 6.2 0.29 11.2 2.0 2.3 2 0 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein TSC22 PF01166.18 EMC87265.1 - 4.5e-05 23.7 2.5 4.5e-05 23.7 2.5 11.1 7 3 4 11 11 11 3 TSC-22/dip/bun family DUF2205 PF10224.9 EMC87265.1 - 0.003 17.5 0.4 0.003 17.5 0.4 9.5 3 3 5 10 10 10 1 Short coiled-coil protein TMF_TATA_bd PF12325.8 EMC87265.1 - 0.009 16.2 9.0 0.009 16.2 9.0 8.8 3 3 4 8 8 8 2 TATA element modulatory factor 1 TATA binding Seryl_tRNA_N PF02403.22 EMC87265.1 - 0.019 15.2 8.6 0.019 15.2 8.6 8.1 2 2 6 8 8 8 0 Seryl-tRNA synthetase N-terminal domain GAS PF13851.6 EMC87265.1 - 0.023 14.1 0.5 0.023 14.1 0.5 7.6 1 1 2 5 5 5 0 Growth-arrest specific micro-tubule binding NRBF2 PF08961.10 EMC87265.1 - 0.026 14.2 1.1 0.026 14.2 1.1 7.1 2 1 5 7 7 7 0 Nuclear receptor-binding factor 2, autophagy regulator ZapB PF06005.12 EMC87265.1 - 0.028 14.9 10.1 0.028 14.9 10.1 10.7 4 3 5 9 9 9 0 Cell division protein ZapB Sp38 PF07354.12 EMC87265.1 - 3.9 6.9 5.7 1.3 8.4 1.1 2.5 2 0 0 2 2 2 0 Zona-pellucida-binding protein (Sp38) Hydrolase_4 PF12146.8 EMC87267.1 - 6e-12 45.3 0.0 1.5e-06 27.7 0.0 2.0 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMC87267.1 - 1.7e-07 31.1 0.0 2.2e-05 24.2 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EMC87267.1 - 5.7e-05 23.1 0.0 8e-05 22.6 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMC87267.1 - 0.00017 22.3 0.0 0.018 15.7 0.0 2.0 1 1 1 2 2 2 1 Alpha/beta hydrolase family Thioesterase PF00975.20 EMC87267.1 - 0.0014 18.8 0.0 0.0023 18.1 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Lipase_3 PF01764.25 EMC87267.1 - 0.014 15.2 0.0 0.021 14.7 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Peptidase_S9 PF00326.21 EMC87267.1 - 0.069 12.6 0.0 0.15 11.5 0.0 1.6 1 1 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 EMC87267.1 - 0.088 12.6 0.1 2.8 7.7 0.0 2.0 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase DUF676 PF05057.14 EMC87267.1 - 0.094 12.2 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) LIDHydrolase PF10230.9 EMC87267.1 - 0.11 12.0 0.0 0.2 11.2 0.0 1.4 1 1 0 1 1 1 0 Lipid-droplet associated hydrolase Phosphorylase PF00343.20 EMC87268.1 - 1.6e-298 992.0 0.0 1.8e-298 991.8 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase fn3 PF00041.21 EMC87269.1 - 6e-10 39.3 0.0 1.2e-09 38.4 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain SPRY PF00622.28 EMC87269.1 - 3.5e-08 33.6 0.0 5.7e-07 29.7 0.0 2.2 1 1 0 1 1 1 1 SPRY domain PRY PF13765.6 EMC87269.1 - 0.00026 20.6 0.1 0.0009 18.8 0.1 2.0 1 1 0 1 1 1 1 SPRY-associated domain ATP-synt_E_2 PF08112.11 EMC87269.1 - 0.18 12.1 0.0 0.42 10.9 0.0 1.5 1 0 0 1 1 1 0 ATP synthase epsilon subunit DUF2203 PF09969.9 EMC87269.1 - 0.2 12.4 1.5 0.35 11.6 1.5 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) 7tm_4 PF13853.6 EMC87271.1 - 2.4e-12 47.2 2.6 2.7e-12 47.0 2.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC87271.1 - 5.8e-12 45.5 2.3 7.2e-12 45.2 2.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-CCCH PF00642.24 EMC87272.1 - 2.4e-12 46.4 18.1 0.00013 21.8 0.5 4.5 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 EMC87272.1 - 1.9e-06 28.1 24.8 0.21 12.1 1.5 4.4 4 0 0 4 4 4 4 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 EMC87272.1 - 2.3e-06 27.8 12.7 0.011 16.0 1.4 2.8 2 1 0 2 2 2 2 Zinc-finger containing family zf-CCCH_4 PF18044.1 EMC87272.1 - 8.8e-05 22.2 1.4 8.8e-05 22.2 1.4 4.9 4 2 0 4 4 4 3 CCCH-type zinc finger Torus PF16131.5 EMC87272.1 - 0.0002 22.0 20.3 0.24 12.1 0.3 4.5 2 2 2 4 4 4 3 Torus domain zf_CCCH_4 PF18345.1 EMC87272.1 - 0.00035 20.5 33.3 0.043 13.9 2.8 6.8 4 4 0 4 4 4 2 Zinc finger domain 7tm_1 PF00001.21 EMC87273.1 - 2e-38 132.2 24.6 2.5e-38 131.9 24.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1772 PF08592.11 EMC87273.1 - 0.0099 16.2 1.2 0.0099 16.2 1.2 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF1772) Abhydrolase_9_N PF15420.6 EMC87273.1 - 1.1 9.2 5.5 1.8 8.5 5.5 1.3 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus 7tm_1 PF00001.21 EMC87274.1 - 1e-36 126.7 26.5 1.3e-36 126.3 26.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Sulfotransfer_2 PF03567.14 EMC87275.1 - 1.7e-50 172.3 1.3 1.7e-50 172.3 1.3 1.4 2 0 0 2 2 2 1 Sulfotransferase family RNA_pol_Rbc25 PF08292.12 EMC87275.1 - 0.16 12.2 0.3 0.24 11.6 0.3 1.3 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 Glyco_transf_24 PF18404.1 EMC87276.1 - 6.1e-148 491.4 4.4 6.1e-148 491.4 4.4 2.3 3 0 0 3 3 3 1 Glucosyltransferase 24 Thioredoxin_15 PF18403.1 EMC87276.1 - 3.9e-68 229.5 1.6 3.5e-66 223.2 1.0 2.7 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_14 PF18402.1 EMC87276.1 - 1.6e-61 208.5 2.1 2.4e-56 191.5 0.1 3.6 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_12 PF18400.1 EMC87276.1 - 4.2e-50 170.3 0.2 9.5e-50 169.1 0.2 1.6 1 0 0 1 1 1 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 EMC87276.1 - 2.4e-40 137.0 0.0 8.6e-40 135.2 0.0 2.0 2 0 0 2 2 2 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_13 PF18401.1 EMC87276.1 - 1.1e-37 128.9 0.6 5.9e-37 126.6 0.1 2.5 3 0 0 3 3 3 1 Thioredoxin-like domain Glyco_transf_8 PF01501.20 EMC87276.1 - 1.6e-06 27.9 0.7 1.6e-06 27.9 0.7 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 8 TPR_2 PF07719.17 EMC87277.1 - 4.2e-33 110.8 20.9 0.00023 21.0 0.0 9.6 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_1 PF00515.28 EMC87277.1 - 1.5e-32 110.0 21.9 7.1e-07 28.8 0.0 9.5 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.6 EMC87277.1 - 1.3e-28 99.3 18.5 7.7e-07 29.5 1.3 6.9 3 3 3 6 6 6 6 Tetratricopeptide repeat TPR_16 PF13432.6 EMC87277.1 - 1.4e-25 89.7 7.1 0.00024 21.7 0.8 6.6 5 1 1 6 6 6 5 Tetratricopeptide repeat DnaJ PF00226.31 EMC87277.1 - 2.7e-21 75.5 2.2 2.7e-21 75.5 2.2 3.4 4 0 0 4 4 3 1 DnaJ domain TPR_11 PF13414.6 EMC87277.1 - 5.7e-21 73.9 19.6 0.00027 20.5 0.2 8.3 6 2 2 8 8 8 6 TPR repeat TPR_14 PF13428.6 EMC87277.1 - 1.1e-20 72.5 14.8 0.018 15.9 0.0 9.8 4 3 6 10 10 10 5 Tetratricopeptide repeat TPR_8 PF13181.6 EMC87277.1 - 2.5e-20 70.9 27.3 0.00013 21.9 0.1 9.3 9 1 1 10 10 9 4 Tetratricopeptide repeat TPR_9 PF13371.6 EMC87277.1 - 6.9e-18 64.6 7.3 1.9e-05 24.7 0.2 5.7 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 EMC87277.1 - 4.2e-14 52.6 21.2 0.016 15.4 0.1 7.6 2 2 4 7 7 7 6 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC87277.1 - 1.8e-13 50.5 20.0 1.6e-05 25.0 0.4 5.3 2 1 4 6 6 6 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EMC87277.1 - 7.4e-13 47.9 11.1 0.0012 19.0 0.0 7.2 9 0 0 9 9 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 EMC87277.1 - 6.4e-12 45.3 19.6 0.48 11.2 0.2 10.0 9 2 0 9 9 8 3 Tetratricopeptide repeat TPR_7 PF13176.6 EMC87277.1 - 1.5e-09 37.2 14.1 4.5 7.5 0.0 8.9 6 2 3 9 9 9 2 Tetratricopeptide repeat TPR_20 PF14561.6 EMC87277.1 - 2.1e-09 37.6 23.0 0.32 11.4 0.0 7.6 4 2 3 7 7 7 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMC87277.1 - 3e-05 24.0 12.5 0.38 10.9 0.5 6.2 6 0 0 6 6 5 1 Fis1 C-terminal tetratricopeptide repeat TPR_15 PF13429.6 EMC87277.1 - 3.6e-05 23.1 16.4 0.18 11.0 0.7 5.8 1 1 5 6 6 6 2 Tetratricopeptide repeat COPI_C PF06957.11 EMC87277.1 - 0.00018 20.4 0.5 0.33 9.6 0.0 3.3 1 1 2 4 4 4 2 Coatomer (COPI) alpha subunit C-terminus TPR_10 PF13374.6 EMC87277.1 - 0.022 14.7 11.8 2.6 8.1 0.0 6.8 7 1 1 8 8 7 0 Tetratricopeptide repeat Vta1_C PF18097.1 EMC87277.1 - 0.033 13.9 0.3 0.033 13.9 0.3 3.2 3 0 0 3 3 2 0 Vta1 C-terminal domain TPR_4 PF07721.14 EMC87277.1 - 0.061 14.0 11.6 1.2 10.0 0.0 6.2 8 0 0 8 8 7 0 Tetratricopeptide repeat DUF4363 PF14276.6 EMC87277.1 - 0.063 13.4 0.3 0.063 13.4 0.3 4.6 4 2 1 5 5 4 0 Domain of unknown function (DUF4363) Alkyl_sulf_dimr PF14863.6 EMC87277.1 - 0.12 12.9 13.5 1.5 9.2 0.7 4.9 2 1 3 6 6 6 0 Alkyl sulfatase dimerisation PknG_TPR PF16918.5 EMC87277.1 - 0.19 10.4 3.6 2.1 7.0 0.1 3.3 1 1 2 4 4 4 0 Protein kinase G tetratricopeptide repeat Virulence_fact PF13769.6 EMC87277.1 - 0.26 11.5 0.1 0.26 11.5 0.1 3.2 3 1 0 3 3 2 0 Virulence factor TPR_3 PF07720.12 EMC87277.1 - 0.68 10.0 5.0 2 8.5 0.2 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat PMP22_Claudin PF00822.20 EMC87279.1 - 2.9e-26 92.3 8.3 3.8e-26 91.9 8.3 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC87279.1 - 0.00021 21.1 10.3 0.00025 20.9 10.3 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF4064 PF13273.6 EMC87279.1 - 0.0091 16.3 3.0 2.1 8.7 3.3 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF4064) Kelch_6 PF13964.6 EMC87279.1 - 0.14 12.5 0.6 2.3 8.6 0.1 2.3 2 0 0 2 2 2 0 Kelch motif DUF3180 PF11377.8 EMC87279.1 - 2.4 8.3 6.4 6.1 7.0 3.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3180) ABC_membrane PF00664.23 EMC87280.1 - 6.2e-78 262.2 39.5 2e-46 158.9 13.7 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EMC87280.1 - 6.4e-57 191.9 0.0 9e-31 107.2 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EMC87280.1 - 3.2e-12 46.4 2.3 0.011 15.2 0.0 4.3 3 1 1 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EMC87280.1 - 3.7e-08 33.9 1.4 0.0028 18.1 0.1 3.0 3 0 0 3 3 3 2 AAA ATPase domain MMR_HSR1 PF01926.23 EMC87280.1 - 1.7e-07 31.3 0.1 0.0058 16.7 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_21 PF13304.6 EMC87280.1 - 1.8e-07 31.3 0.3 0.078 12.8 0.0 3.7 3 1 1 4 4 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EMC87280.1 - 5e-07 29.4 0.0 0.022 14.5 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EMC87280.1 - 2e-06 27.8 0.0 0.018 15.0 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 EMC87280.1 - 7.4e-06 26.1 0.0 0.0092 16.1 0.0 2.7 2 0 0 2 2 2 2 Dynamin family AAA_22 PF13401.6 EMC87280.1 - 6.6e-05 23.2 4.3 0.33 11.2 0.0 4.1 4 1 0 4 4 3 2 AAA domain AAA_23 PF13476.6 EMC87280.1 - 0.00017 22.1 0.0 0.36 11.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain T2SSE PF00437.20 EMC87280.1 - 0.00029 20.0 0.0 0.024 13.7 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein IstB_IS21 PF01695.17 EMC87280.1 - 0.00051 19.8 0.5 1.3 8.7 0.0 3.8 4 0 0 4 4 4 1 IstB-like ATP binding protein DUF87 PF01935.17 EMC87280.1 - 0.0011 19.2 0.4 0.22 11.6 0.0 2.6 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_7 PF12775.7 EMC87280.1 - 0.0014 18.2 0.0 1.7 8.1 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_30 PF13604.6 EMC87280.1 - 0.0044 16.8 0.3 2.5 7.8 0.1 3.0 2 1 0 2 2 2 1 AAA domain cobW PF02492.19 EMC87280.1 - 0.019 14.6 0.1 2.1 7.9 0.1 2.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF815 PF05673.13 EMC87280.1 - 0.048 12.8 0.2 2.6 7.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA PF00004.29 EMC87280.1 - 0.07 13.6 0.4 13 6.2 0.0 3.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_27 PF13514.6 EMC87280.1 - 0.077 12.6 0.1 1.5 8.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EMC87280.1 - 0.08 12.2 0.2 8.3 5.6 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin AAA_PrkA PF08298.11 EMC87280.1 - 0.098 11.5 0.0 1.1 8.1 0.0 2.5 3 0 0 3 3 3 0 PrkA AAA domain Roc PF08477.13 EMC87280.1 - 0.11 12.7 0.1 12 6.2 0.0 2.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_15 PF13175.6 EMC87280.1 - 0.14 11.9 0.0 9.3 5.8 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain Guanylate_kin PF00625.21 EMC87280.1 - 0.17 11.5 0.1 2 8.1 0.0 2.4 2 0 0 2 2 2 0 Guanylate kinase MeaB PF03308.16 EMC87280.1 - 0.18 10.8 0.1 5.4 5.9 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF4637 PF15470.6 EMC87281.1 - 0.0014 18.4 18.1 0.0014 18.4 18.1 2.5 1 1 1 2 2 1 1 Domain of unknown function (DUF4637) HCO3_cotransp PF00955.21 EMC87281.1 - 0.26 10.1 1.6 0.32 9.8 1.6 1.1 1 0 0 1 1 1 0 HCO3- transporter family SLC12 PF03522.15 EMC87281.1 - 0.37 9.7 22.8 0.46 9.5 22.8 1.3 1 0 0 1 1 1 0 Solute carrier family 12 LAP1C PF05609.12 EMC87281.1 - 0.97 8.4 22.5 1.2 8.1 22.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CSG2 PF16965.5 EMC87281.1 - 1.2 8.0 6.6 1.8 7.4 6.6 1.4 1 0 0 1 1 1 0 Ceramide synthase regulator SAPS PF04499.15 EMC87281.1 - 3 6.5 22.6 3.3 6.4 22.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF2370 PF10176.9 EMC87281.1 - 3 7.4 5.4 4.4 6.9 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Hid1 PF12722.7 EMC87281.1 - 4.4 5.3 25.8 5 5.1 25.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SID-1_RNA_chan PF13965.6 EMC87281.1 - 4.6 5.5 10.0 4.8 5.5 10.0 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Otopetrin PF03189.13 EMC87281.1 - 5.5 5.7 7.4 7.1 5.3 7.4 1.3 1 0 0 1 1 1 0 Otopetrin XRN_M PF17846.1 EMC87281.1 - 9.5 5.0 28.9 11 4.8 28.9 1.2 1 0 0 1 1 1 0 Xrn1 helical domain HMG_box PF00505.19 EMC87282.1 - 2e-18 66.6 4.5 3.9e-18 65.6 4.5 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC87282.1 - 7.7e-06 26.4 2.5 1.7e-05 25.3 2.5 1.6 1 0 0 1 1 1 1 HMG-box domain SOXp PF12336.8 EMC87282.1 - 0.0015 19.5 0.3 0.0037 18.3 0.3 1.6 1 0 0 1 1 1 1 SOX transcription factor GpcrRhopsn4 PF10192.9 EMC87283.1 - 3.7e-80 269.0 5.9 4.6e-80 268.7 5.9 1.1 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain Lung_7-TM_R PF06814.13 EMC87283.1 - 3.8e-08 32.9 3.4 7.6e-08 32.0 3.3 1.6 1 1 0 1 1 1 1 Lung seven transmembrane receptor PLAC8 PF04749.17 EMC87283.1 - 0.0055 17.7 1.3 0.0055 17.7 1.3 2.4 3 0 0 3 3 3 1 PLAC8 family DUF1146 PF06612.11 EMC87283.1 - 0.034 14.2 0.2 0.12 12.4 0.2 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1146) MraZ PF02381.18 EMC87283.1 - 0.049 13.6 0.6 0.2 11.7 0.2 2.2 2 0 0 2 2 2 0 MraZ protein, putative antitoxin-like WHIM1 PF15612.6 EMC87283.1 - 0.086 12.4 1.1 0.15 11.6 0.1 1.9 2 0 0 2 2 2 0 WSTF, HB1, Itc1p, MBD9 motif 1 GDP_Man_Dehyd PF16363.5 EMC87284.1 - 1.5e-66 225.1 0.1 1.7e-66 224.9 0.1 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EMC87284.1 - 1.5e-55 188.3 0.0 1.9e-55 188.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EMC87284.1 - 5.7e-24 84.7 0.0 7e-24 84.4 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EMC87284.1 - 1.3e-23 83.6 0.0 5.3e-23 81.6 0.0 1.7 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EMC87284.1 - 2.2e-20 72.8 0.1 3.1e-20 72.3 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EMC87284.1 - 2.5e-15 56.3 0.0 5.3e-15 55.3 0.0 1.4 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EMC87284.1 - 3.4e-07 30.3 0.0 5.3e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding TrkA_N PF02254.18 EMC87284.1 - 0.2 11.9 0.1 0.41 10.9 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain Tyrosinase PF00264.20 EMC87285.1 - 1.2e-18 68.2 0.0 2.2e-18 67.3 0.0 1.5 1 1 0 1 1 1 1 Common central domain of tyrosinase Glypican PF01153.19 EMC87286.1 - 6.1e-32 111.2 0.2 6.4e-32 111.1 0.2 1.0 1 0 0 1 1 1 1 Glypican Serglycin PF04360.12 EMC87286.1 - 0.013 15.5 0.0 0.013 15.4 0.0 1.1 1 0 0 1 1 1 0 Serglycin TGF_beta_GS PF08515.12 EMC87286.1 - 0.49 9.9 4.1 0.76 9.3 4.1 1.3 1 0 0 1 1 1 0 Transforming growth factor beta type I GS-motif Yae1_N PF09811.9 EMC87287.1 - 5e-07 29.3 38.4 9.8e+02 -0.4 31.6 4.2 2 1 0 2 2 2 0 Essential protein Yae1, N terminal Glypican PF01153.19 EMC87289.1 - 2.6e-143 478.8 0.3 3.2e-143 478.5 0.3 1.0 1 0 0 1 1 1 1 Glypican LRR_8 PF13855.6 EMC87290.1 - 2.6e-21 75.2 32.5 2.1e-06 27.4 4.0 6.5 6 0 0 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 EMC87290.1 - 4.5e-12 46.0 46.4 0.00074 19.9 0.7 9.3 6 2 2 9 9 9 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC87290.1 - 0.064 13.8 17.4 44 5.2 0.0 9.0 7 1 0 7 7 7 0 Leucine Rich Repeat RRM_1 PF00076.22 EMC87291.1 - 2.5e-43 145.8 0.1 1e-18 66.9 0.0 3.6 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMC87291.1 - 0.00071 19.6 2.0 0.69 10.1 0.0 3.5 4 1 0 4 4 4 2 RNA recognition motif OB_RNB PF08206.11 EMC87291.1 - 0.051 13.3 0.1 5.5 6.8 0.0 2.6 2 0 0 2 2 2 0 Ribonuclease B OB domain RRM_3 PF08777.11 EMC87291.1 - 0.072 13.1 0.0 5.8 7.0 0.0 2.8 2 0 0 2 2 2 0 RNA binding motif zf-RNPHF PF08080.12 EMC87292.1 - 0.046 13.7 0.2 0.11 12.5 0.2 1.6 1 0 0 1 1 1 0 RNPHF zinc finger OSR1_C PF12202.8 EMC87293.1 - 0.0038 17.4 0.1 0.0089 16.2 0.1 1.7 1 1 0 1 1 1 1 Oxidative-stress-responsive kinase 1 C-terminal domain Pkinase_Tyr PF07714.17 EMC87294.1 - 3.6e-17 62.5 0.0 3.9e-17 62.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC87294.1 - 6.4e-16 58.5 0.0 8.4e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain LisH_2 PF16045.5 EMC87295.1 - 0.017 14.1 2.1 1.5e+02 1.5 0.0 5.3 5 0 0 5 5 5 0 LisH Pirin_C PF05726.13 EMC87295.1 - 0.038 14.3 0.0 46 4.4 0.0 3.6 1 1 4 5 5 5 0 Pirin C-terminal cupin domain Plectin PF00681.20 EMC87296.1 - 1.3e-47 159.4 0.1 2.4e-19 68.9 0.0 5.2 3 1 1 4 4 4 4 Plectin repeat GatB_Yqey PF02637.18 EMC87296.1 - 4.4e-07 29.9 17.2 1.2 9.0 0.1 6.7 8 0 0 8 8 8 4 GatB domain Nitr_red_alph_N PF14710.6 EMC87296.1 - 0.00047 20.5 3.1 14 6.3 0.0 3.7 3 0 0 3 3 3 3 Respiratory nitrate reductase alpha N-terminal SelB-wing_1 PF09105.10 EMC87296.1 - 0.0059 16.5 0.2 74 3.4 0.0 4.5 4 0 0 4 4 4 0 Elongation factor SelB, winged helix VbhA PF18495.1 EMC87296.1 - 0.0066 16.3 0.1 1.1e+02 2.7 0.0 5.0 5 0 0 5 5 5 0 Antitoxin VbhA DUF2179 PF10035.9 EMC87296.1 - 0.01 15.5 4.7 13 5.6 0.0 4.6 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2179) DUF1798 PF08807.10 EMC87296.1 - 0.057 13.5 0.1 1.2e+02 2.9 0.0 3.7 3 0 0 3 3 3 0 Bacterial domain of unknown function (DUF1798) DUF2989 PF11207.8 EMC87296.1 - 0.081 12.7 4.3 49 3.6 0.1 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2989) DUF2730 PF10805.8 EMC87296.1 - 1.1 9.3 14.9 18 5.5 0.1 5.1 7 0 0 7 7 7 0 Protein of unknown function (DUF2730) Plectin PF00681.20 EMC87298.1 - 7.8e-104 339.3 2.9 1.1e-21 76.4 0.0 10.3 9 2 2 11 11 11 8 Plectin repeat HTH_10 PF04967.12 EMC87298.1 - 0.011 15.5 0.2 16 5.4 0.0 3.7 4 0 0 4 4 4 0 HTH DNA binding domain Pkinase PF00069.25 EMC87299.1 - 2.6e-20 72.9 0.0 3.4e-20 72.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87299.1 - 7.1e-13 48.4 0.0 9.6e-13 48.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC87299.1 - 5.9e-10 38.5 0.1 9.3e-10 37.8 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMC87299.1 - 0.00033 20.6 0.0 0.0013 18.7 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EMC87299.1 - 0.048 12.6 0.1 0.068 12.1 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 EMC87299.1 - 0.091 12.1 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Glypican PF01153.19 EMC87300.1 - 1.3e-109 367.6 2.5 1.4e-109 367.4 2.5 1.0 1 0 0 1 1 1 1 Glypican Fz PF01392.22 EMC87300.1 - 0.0096 16.5 0.3 0.0096 16.5 0.3 2.1 2 0 0 2 2 2 1 Fz domain Spore_III_AB PF09548.10 EMC87300.1 - 0.2 11.7 1.5 3.2 7.8 0.5 2.4 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) MYEOV2 PF15004.6 EMC87301.1 - 4.8e-34 116.6 6.9 5.3e-34 116.5 6.9 1.0 1 0 0 1 1 1 1 Myeloma-overexpressed-like C1q PF00386.21 EMC87302.1 - 3.3e-41 140.5 0.6 4e-41 140.2 0.6 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 EMC87302.1 - 1.6e-10 40.6 32.5 2.6e-09 36.7 32.5 2.1 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) BclA_C PF18573.1 EMC87302.1 - 0.037 13.9 0.0 0.053 13.4 0.0 1.1 1 0 0 1 1 1 0 BclA C-terminal domain Glyco_transf_29 PF00777.18 EMC87303.1 - 2.4e-37 128.8 0.0 4.4e-37 127.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) 7tm_1 PF00001.21 EMC87304.1 - 1.1e-21 77.3 11.1 1.4e-21 77.0 11.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC87304.1 - 0.00098 18.8 14.6 0.0012 18.5 14.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 EMC87304.1 - 0.0017 17.8 10.0 0.0021 17.5 10.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 EMC87305.1 - 6.4e-29 101.1 28.2 7.9e-29 100.8 28.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Renin_r PF07850.14 EMC87305.1 - 0.23 12.1 1.3 1 10.0 0.1 2.5 2 0 0 2 2 2 0 Renin receptor-like protein 7tm_1 PF00001.21 EMC87306.1 - 2e-33 115.9 15.2 2.4e-33 115.6 15.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 EMC87306.1 - 0.00017 21.1 8.3 0.00051 19.5 4.0 2.2 1 1 1 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_1 PF00001.21 EMC87307.1 - 3.3e-36 125.0 30.1 4.1e-36 124.7 30.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC87307.1 - 0.0026 17.4 17.8 0.0026 17.4 17.8 2.2 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.21 EMC87308.1 - 5e-33 114.5 22.3 5.9e-33 114.3 22.3 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) BRICHOS PF04089.14 EMC87309.1 - 2.9e-22 78.7 0.0 4.3e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 BRICHOS domain Mo25 PF08569.11 EMC87310.1 - 1e-142 475.3 16.6 1.2e-142 475.2 16.6 1.0 1 0 0 1 1 1 1 Mo25-like HLH PF00010.26 EMC87311.1 - 5.4e-16 58.3 2.2 9.6e-16 57.5 2.2 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 EMC87311.1 - 2.4e-05 24.5 0.0 5.2e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Hairy Orange CBP_BcsO PF17037.5 EMC87311.1 - 0.049 13.8 1.4 0.089 12.9 1.4 1.4 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsO Period_C PF12114.8 EMC87312.1 - 1.4e-92 308.7 6.0 1.4e-92 308.7 6.0 3.5 3 0 0 3 3 3 1 Period protein 2/3C-terminal region PAS_3 PF08447.12 EMC87312.1 - 1.1e-12 48.0 0.0 5.2e-12 45.9 0.0 2.1 2 0 0 2 2 2 1 PAS fold PAS_11 PF14598.6 EMC87312.1 - 1.4e-08 34.8 0.0 5.7e-08 32.9 0.0 2.1 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EMC87312.1 - 8.8e-06 25.7 0.0 0.00038 20.4 0.0 2.6 2 0 0 2 2 2 1 PAS fold Synaptobrevin PF00957.21 EMC87313.1 - 2.4e-34 117.0 3.8 3e-34 116.7 3.8 1.0 1 0 0 1 1 1 1 Synaptobrevin MCU PF04678.13 EMC87313.1 - 0.0046 17.1 0.6 0.0055 16.8 0.6 1.0 1 0 0 1 1 1 1 Mitochondrial calcium uniporter MgtE PF01769.16 EMC87313.1 - 0.068 13.5 0.0 0.088 13.2 0.0 1.1 1 0 0 1 1 1 0 Divalent cation transporter Spore_III_AB PF09548.10 EMC87313.1 - 0.07 13.2 0.5 0.11 12.6 0.5 1.6 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) Duffy_binding PF05424.11 EMC87313.1 - 0.076 13.1 0.1 0.09 12.8 0.1 1.1 1 0 0 1 1 1 0 Duffy binding domain PRIMA1 PF16101.5 EMC87313.1 - 0.13 12.3 1.3 0.2 11.7 0.3 1.7 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 SNARE PF05739.19 EMC87313.1 - 2.7 8.0 12.1 0.6 10.1 7.5 2.1 2 0 0 2 2 2 0 SNARE domain PI3Ka PF00613.20 EMC87314.1 - 3.3e-62 209.2 1.2 7.5e-62 208.0 1.2 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EMC87314.1 - 1e-59 202.4 0.0 2.4e-59 201.2 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_p85B PF02192.16 EMC87314.1 - 2.7e-33 113.5 0.1 9.8e-33 111.7 0.1 2.0 1 0 0 1 1 1 1 PI3-kinase family, p85-binding domain PI3K_rbd PF00794.18 EMC87314.1 - 1.4e-31 108.8 0.1 3.4e-31 107.6 0.1 1.7 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain PI3K_C2 PF00792.24 EMC87314.1 - 1.2e-19 70.7 0.0 2.5e-19 69.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 RWD PF05773.22 EMC87314.1 - 0.0032 17.8 0.2 1.3 9.4 0.1 2.9 2 0 0 2 2 2 2 RWD domain DUF4135 PF13575.6 EMC87314.1 - 0.034 13.5 0.0 0.06 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) Forkhead PF00250.18 EMC87315.1 - 3.3e-39 133.0 0.0 4.5e-39 132.6 0.0 1.2 1 0 0 1 1 1 1 Forkhead domain Coatomer_WDAD PF04053.14 EMC87316.1 - 8.1e-171 569.0 0.0 1.4e-170 568.2 0.0 1.4 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.32 EMC87316.1 - 3.5e-41 138.4 8.1 1.3e-09 38.5 0.1 8.1 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC87316.1 - 3.6e-07 30.4 0.6 0.63 10.4 0.1 6.4 4 3 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain MetallophosC PF16370.5 EMC87316.1 - 0.07 13.4 0.0 0.6 10.3 0.0 2.2 1 1 1 2 2 2 0 C terminal of Calcineurin-like phosphoesterase Lipocalin PF00061.23 EMC87317.1 - 6.9e-18 65.2 4.0 7.6e-18 65.1 4.0 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 EMC87317.1 - 4.9e-08 33.0 0.3 5.6e-08 32.8 0.3 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin PF00061.23 EMC87318.1 - 6.8e-18 65.3 0.3 7.8e-18 65.1 0.3 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 EMC87318.1 - 2.7e-05 24.1 0.2 3.3e-05 23.8 0.2 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family CTP_transf_like PF01467.26 EMC87319.1 - 1.5e-22 80.3 0.0 5.5e-22 78.5 0.0 1.8 1 1 0 1 1 1 1 Cytidylyltransferase-like DUF2513 PF10711.9 EMC87319.1 - 0.072 13.4 0.1 1.1 9.6 0.1 2.3 1 1 0 1 1 1 0 Hypothetical protein (DUF2513) DARPP-32 PF05395.12 EMC87320.1 - 4.1e-26 92.1 2.3 4.6e-26 92.0 2.3 1.0 1 0 0 1 1 1 1 Protein phosphatase inhibitor 1/DARPP-32 Collagen PF01391.18 EMC87322.1 - 3.6e-26 90.7 73.1 1.9e-08 33.9 12.4 5.1 2 1 3 5 5 5 5 Collagen triple helix repeat (20 copies) LRR_8 PF13855.6 EMC87326.1 - 3.9e-37 125.8 29.1 4.2e-14 52.1 12.2 3.6 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EMC87326.1 - 1.8e-17 63.2 17.3 8.7e-06 26.0 0.1 4.6 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) I-set PF07679.16 EMC87326.1 - 1.9e-15 56.7 0.0 3.8e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain LRR_5 PF13306.6 EMC87326.1 - 3.2e-15 56.2 0.1 1e-14 54.6 0.1 1.8 1 1 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) Ig_3 PF13927.6 EMC87326.1 - 2.1e-13 50.6 0.0 5.1e-13 49.4 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC87326.1 - 1e-09 38.5 0.0 2e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.33 EMC87326.1 - 1.1e-09 37.5 8.5 0.95 10.3 0.0 6.7 6 0 0 6 6 6 3 Leucine Rich Repeat LRR_9 PF14580.6 EMC87326.1 - 6.6e-09 35.5 5.7 5.6e-05 22.7 3.7 2.4 1 1 1 2 2 2 2 Leucine-rich repeat Ig_2 PF13895.6 EMC87326.1 - 8.6e-07 29.2 0.0 2.2e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain fn3 PF00041.21 EMC87326.1 - 0.0003 21.0 0.0 0.00088 19.6 0.0 1.8 1 0 0 1 1 1 1 Fibronectin type III domain C2-set_2 PF08205.12 EMC87326.1 - 0.0094 16.0 0.0 0.027 14.5 0.0 1.8 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain LSR PF05624.14 EMC87326.1 - 0.013 15.4 1.5 0.013 15.4 1.5 2.5 2 0 0 2 2 2 0 Lipolysis stimulated receptor (LSR) V-set PF07686.17 EMC87326.1 - 0.025 14.7 0.0 6.5 7.0 0.0 2.5 1 1 1 2 2 2 0 Immunoglobulin V-set domain DUF240 PF03086.14 EMC87326.1 - 0.12 12.4 4.6 0.2 11.6 3.6 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF240) Adipokin_hormo PF06377.11 EMC87328.1 - 0.74 10.2 9.8 4.5 7.7 0.3 2.9 2 1 0 2 2 2 0 Adipokinetic hormone QWRF PF04484.12 EMC87329.1 - 5 6.8 7.6 5.3 6.7 7.6 1.1 1 0 0 1 1 1 0 QWRF family Kelch_1 PF01344.25 EMC87330.1 - 3.5e-65 215.4 11.0 3.3e-14 52.2 0.2 5.3 5 0 0 5 5 5 5 Kelch motif Kelch_6 PF13964.6 EMC87330.1 - 2.1e-39 132.5 5.3 1e-08 35.1 0.0 5.7 3 2 3 6 6 6 5 Kelch motif BACK PF07707.15 EMC87330.1 - 4.5e-35 119.9 1.0 4.5e-35 119.9 1.0 1.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 EMC87330.1 - 1e-30 106.2 0.8 1e-30 106.2 0.8 2.3 3 0 0 3 3 3 1 BTB/POZ domain Kelch_2 PF07646.15 EMC87330.1 - 1.4e-24 85.1 7.3 0.00016 21.5 0.0 6.0 5 1 0 5 5 5 5 Kelch motif Kelch_3 PF13415.6 EMC87330.1 - 7e-22 77.2 3.8 0.0029 17.9 0.0 5.3 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_4 PF13418.6 EMC87330.1 - 4.2e-15 55.5 6.5 2e-05 24.5 0.0 5.7 4 1 1 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC87330.1 - 1.2e-08 34.8 5.0 0.029 14.4 0.1 4.7 5 0 0 5 5 5 3 Kelch motif TPR_14 PF13428.6 EMC87331.1 - 6.3e-08 32.8 0.3 0.73 10.8 0.0 3.3 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 EMC87331.1 - 9.1e-07 29.1 0.4 0.64 10.3 0.2 3.2 2 1 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EMC87331.1 - 3.2e-06 26.8 0.7 0.66 10.2 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMC87331.1 - 5.4e-05 23.6 0.1 1.2 9.7 0.1 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMC87331.1 - 0.00026 21.6 0.0 0.0068 17.0 0.0 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMC87331.1 - 0.0011 18.6 0.3 0.0096 15.6 0.0 2.6 3 0 0 3 3 3 1 TPR repeat TPR_1 PF00515.28 EMC87331.1 - 0.0064 16.3 1.5 2 8.4 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC5 PF12862.7 EMC87331.1 - 0.011 15.7 1.0 0.28 11.3 0.2 2.4 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 5 PPR PF01535.20 EMC87331.1 - 0.028 14.6 0.3 2.3 8.6 0.1 3.1 3 0 0 3 3 3 0 PPR repeat TPR_10 PF13374.6 EMC87331.1 - 0.029 14.3 3.0 3.1 7.8 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC87331.1 - 0.032 14.5 0.0 11 6.4 0.0 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EMC87331.1 - 0.035 14.3 1.4 34 5.0 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMC87331.1 - 0.039 14.6 0.3 22 6.0 0.0 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_21 PF09976.9 EMC87331.1 - 0.065 12.9 0.5 0.42 10.3 0.5 1.9 1 1 0 1 1 1 0 Tetratricopeptide repeat-like domain ALMS_motif PF15309.6 EMC87331.1 - 0.069 13.6 1.0 0.1 13.0 1.0 1.2 1 0 0 1 1 1 0 ALMS motif FKBP_C PF00254.28 EMC87332.1 - 2.6e-33 114.2 0.1 3.1e-33 114.0 0.1 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase SOUL PF04832.12 EMC87333.1 - 2.3e-35 122.3 0.0 3e-35 121.9 0.0 1.2 1 0 0 1 1 1 1 SOUL heme-binding protein Myb_DNA-binding PF00249.31 EMC87334.1 - 0.007 16.5 0.0 0.014 15.6 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain SANTA PF09133.10 EMC87335.1 - 9.8e-30 102.9 0.3 1.1e-29 102.7 0.3 1.0 1 0 0 1 1 1 1 SANTA (SANT Associated) Ras PF00071.22 EMC87336.1 - 7.8e-56 188.1 0.3 9.3e-56 187.9 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC87336.1 - 1.7e-19 70.2 0.0 3.1e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC87336.1 - 2e-10 40.4 0.0 2.6e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EMC87336.1 - 7.1e-09 35.8 0.1 5.3e-05 23.2 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EMC87336.1 - 6.9e-05 22.5 0.2 0.0002 20.9 0.1 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EMC87336.1 - 0.0015 18.6 0.0 0.0031 17.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 EMC87336.1 - 0.01 15.2 0.1 1.2 8.3 0.0 2.2 2 0 0 2 2 2 0 Septin AAA_25 PF13481.6 EMC87336.1 - 0.012 15.2 0.2 0.055 13.0 0.1 1.9 1 1 1 2 2 2 0 AAA domain ThiF PF00899.21 EMC87336.1 - 0.11 11.8 2.0 0.18 11.1 0.1 2.1 2 0 0 2 2 2 0 ThiF family MeaB PF03308.16 EMC87336.1 - 0.15 11.0 0.4 2 7.3 0.3 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Med1 PF10744.9 EMC87337.1 - 1.1e-56 192.7 0.0 1.4e-56 192.4 0.0 1.1 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 Yae1_N PF09811.9 EMC87338.1 - 6.5e-13 48.1 2.0 6.5e-13 48.1 2.0 1.6 2 0 0 2 2 2 1 Essential protein Yae1, N terminal DUF2385 PF09539.10 EMC87338.1 - 0.016 15.7 0.1 0.089 13.3 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2385) Clathrin PF00637.20 EMC87339.1 - 2.4e-23 82.6 1.7 2.4e-23 82.6 1.7 2.6 3 0 0 3 3 3 1 Region in Clathrin and VPS Vps39_2 PF10367.9 EMC87339.1 - 0.00038 20.9 0.2 0.0012 19.2 0.2 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 ANAPC4_WD40 PF12894.7 EMC87339.1 - 0.0015 18.7 0.4 0.31 11.3 0.0 3.3 3 2 1 4 4 3 1 Anaphase-promoting complex subunit 4 WD40 domain zf-RING_5 PF14634.6 EMC87339.1 - 0.01 15.7 5.0 0.039 13.9 5.0 2.1 1 0 0 1 1 1 0 zinc-RING finger domain Vps39_1 PF10366.9 EMC87339.1 - 0.087 13.1 5.4 0.33 11.2 0.1 3.4 3 1 1 4 4 4 0 Vacuolar sorting protein 39 domain 1 zf-RING_2 PF13639.6 EMC87339.1 - 0.17 12.3 11.3 0.029 14.7 6.4 2.4 2 0 0 2 2 2 0 Ring finger domain zf-C3H2C3 PF17122.5 EMC87339.1 - 0.43 10.7 5.9 0.48 10.5 3.9 2.1 1 1 0 1 1 1 0 Zinc-finger zf-RING_11 PF17123.5 EMC87339.1 - 0.65 9.8 8.2 0.23 11.2 4.5 2.3 2 0 0 2 2 2 0 RING-like zinc finger zf-rbx1 PF12678.7 EMC87339.1 - 0.66 10.3 5.6 0.9 9.9 4.1 2.1 2 0 0 2 2 1 0 RING-H2 zinc finger domain PHD PF00628.29 EMC87339.1 - 0.77 9.7 3.4 2.5 8.1 3.4 2.0 1 0 0 1 1 1 0 PHD-finger zf-RING_UBOX PF13445.6 EMC87339.1 - 3 8.0 6.1 18 5.4 6.1 2.3 1 1 0 1 1 1 0 RING-type zinc-finger BAR PF03114.18 EMC87341.1 - 2.7e-50 171.3 7.4 3.8e-50 170.8 7.4 1.2 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.6 EMC87341.1 - 5.3e-09 35.8 0.0 1.3e-08 34.6 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC87341.1 - 2.7e-06 26.9 0.1 3e-05 23.5 0.1 2.3 1 1 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC87341.1 - 0.0002 20.9 0.0 0.00042 19.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain BAR_3 PF16746.5 EMC87341.1 - 0.00053 19.8 3.0 0.00099 18.9 3.0 1.4 1 1 0 1 1 1 1 BAR domain of APPL family Arfaptin PF06456.13 EMC87341.1 - 0.011 15.4 4.1 0.016 14.8 4.1 1.3 1 0 0 1 1 1 0 Arfaptin-like domain EzrA PF06160.12 EMC87341.1 - 0.015 13.5 5.0 0.71 8.0 0.3 2.1 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA HD_3 PF13023.6 EMC87341.1 - 0.038 13.9 0.3 0.038 13.9 0.3 2.3 2 1 1 3 3 3 0 HD domain OmpH PF03938.14 EMC87341.1 - 0.27 11.6 7.1 0.79 10.1 0.2 2.6 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Jnk-SapK_ap_N PF09744.9 EMC87341.1 - 0.64 10.2 10.2 0.13 12.5 3.1 2.3 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Occludin_ELL PF07303.13 EMC87341.1 - 5.6 7.8 6.9 2.7 8.8 1.0 2.5 2 0 0 2 2 2 0 Occludin homology domain V-set PF07686.17 EMC87342.1 - 2.1e-10 40.7 0.7 2.5e-10 40.5 0.7 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC87342.1 - 0.0016 19.0 3.5 0.004 17.7 3.5 1.6 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC87342.1 - 0.0024 17.9 1.0 0.0049 16.9 1.0 1.5 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC87342.1 - 0.015 15.5 3.4 0.056 13.6 3.4 2.0 1 1 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 EMC87343.1 - 1.6e-14 54.0 0.0 1.9e-14 53.7 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC87343.1 - 4.1e-06 27.3 0.3 1.4e-05 25.6 0.3 1.8 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC87343.1 - 0.00061 19.8 0.0 0.00091 19.2 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC87343.1 - 0.0009 19.4 0.0 0.0022 18.1 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC87343.1 - 0.0016 18.8 0.2 0.0039 17.5 0.2 1.6 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC87344.1 - 5.6e-11 42.6 0.0 6.6e-11 42.3 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC87344.1 - 0.00098 19.7 0.0 0.0015 19.1 0.0 1.3 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC87344.1 - 0.056 13.5 0.0 0.091 12.8 0.0 1.4 1 1 0 1 1 1 0 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC87344.1 - 0.069 13.5 0.0 0.51 10.7 0.0 1.9 1 1 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 EMC87345.1 - 1.9e-09 37.7 0.2 2.4e-09 37.3 0.2 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC87345.1 - 0.0017 18.9 1.0 0.0037 17.8 1.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC87345.1 - 0.0017 18.4 0.3 0.0034 17.4 0.3 1.5 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC87345.1 - 0.013 15.7 1.4 0.051 13.7 1.4 1.9 1 1 0 1 1 1 0 Immunoglobulin domain Ig_2 PF13895.6 EMC87345.1 - 0.47 10.8 2.9 2.1 8.7 2.9 1.9 1 1 0 1 1 1 0 Immunoglobulin domain RINGv PF12906.7 EMC87346.1 - 1.6e-15 57.0 16.6 4.4e-15 55.5 16.6 1.8 1 0 0 1 1 1 1 RING-variant domain DctQ PF04290.12 EMC87346.1 - 0.0082 16.1 1.2 0.015 15.2 1.2 1.4 1 0 0 1 1 1 1 Tripartite ATP-independent periplasmic transporters, DctQ component zf-ANAPC11 PF12861.7 EMC87346.1 - 0.016 15.2 6.4 0.051 13.6 6.4 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EMC87346.1 - 0.034 14.5 16.7 0.034 14.5 16.7 2.5 2 0 0 2 2 2 0 Ring finger domain zf-rbx1 PF12678.7 EMC87346.1 - 1.3 9.4 12.2 7.8 6.9 12.2 2.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain FANCL_C PF11793.8 EMC87346.1 - 6.3 7.0 12.1 3.6 7.8 9.2 2.2 2 0 0 2 2 2 0 FANCL C-terminal domain ubiquitin PF00240.23 EMC87347.1 - 2.5e-19 68.8 0.0 5e-19 67.8 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family zf-AN1 PF01428.16 EMC87347.1 - 1e-08 35.2 8.7 1.9e-08 34.3 8.7 1.5 1 0 0 1 1 1 1 AN1-like Zinc finger Rad60-SLD PF11976.8 EMC87347.1 - 3.2e-05 23.7 0.0 6.9e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EMC87347.1 - 9e-05 22.9 0.0 0.00032 21.1 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin-like domain PSP94 PF05825.11 EMC87350.1 - 9.5e-21 74.2 9.0 1e-20 74.1 9.0 1.0 1 0 0 1 1 1 1 Beta-microseminoprotein (PSP-94) TILa PF12714.7 EMC87350.1 - 0.072 13.1 9.6 0.13 12.3 9.6 1.7 1 1 0 1 1 1 0 TILa domain VWC PF00093.18 EMC87350.1 - 0.21 11.9 9.5 0.7 10.2 9.5 1.8 1 1 0 1 1 1 0 von Willebrand factor type C domain Annexin PF00191.20 EMC87351.1 - 5.3e-98 321.1 14.3 1.5e-26 92.2 0.9 4.1 4 0 0 4 4 4 4 Annexin Myb_DNA-bind_7 PF15963.5 EMC87351.1 - 9.9e-05 22.2 0.5 0.7 9.8 0.0 3.6 4 0 0 4 4 4 2 Myb DNA-binding like Sigma70_ner PF04546.13 EMC87351.1 - 0.0065 16.4 1.4 5.3 6.9 0.1 3.0 2 1 1 3 3 3 2 Sigma-70, non-essential region FeoB_Cyto PF17910.1 EMC87351.1 - 0.027 15.0 4.0 0.14 12.7 0.3 3.1 3 0 0 3 3 3 0 FeoB cytosolic helical domain DUF3500 PF12006.8 EMC87351.1 - 0.034 13.6 0.1 0.053 13.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3500) PqqD PF05402.12 EMC87351.1 - 0.049 13.9 0.8 0.85 10.0 0.2 2.8 2 1 1 3 3 3 0 Coenzyme PQQ synthesis protein D (PqqD) DUF445 PF04286.12 EMC87351.1 - 0.11 12.3 0.9 0.15 11.8 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Mog1 PF04603.12 EMC87351.1 - 0.12 12.8 0.1 4.3 7.7 0.0 2.3 2 0 0 2 2 2 0 Ran-interacting Mog1 protein UBA_2 PF08587.11 EMC87351.1 - 0.13 12.4 0.5 6.1 7.1 0.2 2.7 2 0 0 2 2 2 0 Ubiquitin associated domain (UBA) NIL PF09383.10 EMC87351.1 - 0.14 12.1 0.1 1.2 9.1 0.0 2.4 2 0 0 2 2 2 0 NIL domain Ant_C PF05586.11 EMC87352.1 - 7e-49 164.4 0.7 1.2e-48 163.7 0.7 1.4 1 0 0 1 1 1 1 Anthrax receptor C-terminus region Anth_Ig PF05587.13 EMC87352.1 - 5.2e-42 142.3 1.4 8.7e-42 141.6 1.4 1.4 1 0 0 1 1 1 1 Anthrax receptor extracellular domain VWA PF00092.28 EMC87352.1 - 1e-18 68.2 0.0 1.6e-18 67.6 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 EMC87352.1 - 0.00042 19.8 0.0 0.00067 19.1 0.0 1.2 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein DUF3328 PF11807.8 EMC87352.1 - 7 6.3 5.7 1.9 8.2 0.1 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF3328) zf-C2H2_4 PF13894.6 EMC87353.1 - 3.2e-06 27.5 25.1 0.024 15.5 4.8 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger SET PF00856.28 EMC87353.1 - 0.0019 18.6 2.5 0.012 16.0 0.0 2.6 2 1 0 2 2 2 1 SET domain zf-C2H2 PF00096.26 EMC87353.1 - 0.0041 17.5 28.2 0.13 12.8 6.7 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 EMC87353.1 - 0.058 13.7 17.3 1.6 9.1 2.8 3.5 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2H2_9 PF16293.5 EMC87353.1 - 0.12 12.2 5.0 0.72 9.8 0.6 2.8 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) Zn-C2H2_12 PF18112.1 EMC87353.1 - 0.29 11.6 4.1 1.1 9.8 4.1 2.0 1 0 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain GAGA PF09237.11 EMC87353.1 - 0.3 10.9 4.3 0.32 10.8 2.2 2.1 2 0 0 2 2 2 0 GAGA factor zf-C2H2_jaz PF12171.8 EMC87353.1 - 0.48 10.8 19.0 0.38 11.1 1.6 3.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 EMC87353.1 - 3.9 8.1 23.2 3.6 8.2 7.7 4.0 3 1 0 3 3 3 0 Zinc-finger double domain CpXC PF14353.6 EMC87353.1 - 5.2 7.1 9.8 19 5.3 0.2 3.7 3 1 0 3 3 3 0 CpXC protein Peptidase_S41_N PF11918.8 EMC87354.1 - 3.7e-118 389.4 14.2 7e-38 129.8 0.3 4.5 4 0 0 4 4 4 4 N-terminal domain of Peptidase_S41 in eukaryotic IRBP Peptidase_S41 PF03572.18 EMC87354.1 - 5.4e-97 322.1 0.0 1.2e-24 86.8 0.0 4.3 4 0 0 4 4 4 4 Peptidase family S41 muHD PF10291.9 EMC87354.1 - 0.0057 16.1 0.0 4.1 6.8 0.0 3.3 3 0 0 3 3 3 2 Muniscin C-terminal mu homology domain TGF_beta PF00019.20 EMC87355.1 - 4.5e-29 101.5 0.4 9.7e-29 100.4 0.4 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 EMC87355.1 - 3.5e-18 66.2 1.2 2.7e-17 63.4 1.2 2.1 1 1 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 EMC87356.1 - 1.2e-29 103.3 1.5 1.7e-29 102.8 0.5 1.8 2 0 0 2 2 2 1 Transforming growth factor beta like domain Stb3 PF10330.9 EMC87356.1 - 0.16 12.0 0.7 2.3 8.3 0.1 2.6 3 0 0 3 3 3 0 Putative Sin3 binding protein Y_phosphatase PF00102.27 EMC87357.1 - 1.6e-75 253.7 0.2 2e-75 253.4 0.2 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EMC87357.1 - 6.4e-05 22.8 0.1 0.00011 22.1 0.1 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EMC87357.1 - 0.0091 16.1 0.0 0.021 15.0 0.0 1.7 1 0 0 1 1 1 1 Inositol hexakisphosphate PDZ PF00595.24 EMC87358.1 - 2e-42 143.4 7.8 8.2e-14 51.7 0.7 3.2 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 EMC87358.1 - 1.1e-37 127.7 1.5 6.7e-13 48.3 0.0 3.3 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 EMC87358.1 - 2.2e-17 63.1 0.5 3.2e-05 24.2 0.0 3.4 3 0 0 3 3 3 3 PDZ domain PDZ_4 PF17816.1 EMC87358.1 - 0.00049 20.5 0.0 0.79 10.1 0.0 3.0 3 0 0 3 3 3 2 PDZ domain Tricorn_PDZ PF14685.6 EMC87358.1 - 0.025 14.6 0.6 0.75 9.8 0.1 2.9 3 1 0 3 3 3 0 Tricorn protease PDZ domain Pkinase PF00069.25 EMC87359.1 - 2e-63 214.2 0.0 2.5e-63 213.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87359.1 - 2.5e-29 102.4 0.0 3.3e-29 102.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMC87359.1 - 2.6e-07 30.2 0.2 4e-07 29.6 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EMC87359.1 - 2.6e-05 23.7 0.1 4.8e-05 22.8 0.1 1.5 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EMC87359.1 - 0.00045 19.9 0.2 0.00088 18.9 0.2 1.5 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 EMC87359.1 - 0.0007 19.6 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF530 PF04409.12 EMC87359.1 - 0.046 12.1 0.0 0.091 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF530) FTA2 PF13095.6 EMC87359.1 - 0.048 13.3 0.1 0.1 12.2 0.0 1.6 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RhoGAP PF00620.27 EMC87360.1 - 5.5e-48 162.6 1.0 8.9e-48 162.0 0.0 1.8 2 0 0 2 2 2 1 RhoGAP domain DUF812 PF05667.11 EMC87360.1 - 0.00045 19.2 4.6 0.00061 18.8 4.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) PH PF00169.29 EMC87360.1 - 0.00063 20.2 0.0 0.0027 18.2 0.0 2.1 1 0 0 1 1 1 1 PH domain ATG16 PF08614.11 EMC87360.1 - 0.00076 19.8 12.2 0.0019 18.5 12.2 1.6 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) RIH_assoc PF08454.11 EMC87360.1 - 0.013 15.4 0.7 0.028 14.2 0.1 1.8 2 0 0 2 2 2 0 RyR and IP3R Homology associated Tmemb_cc2 PF10267.9 EMC87360.1 - 0.017 14.3 6.0 0.028 13.6 6.0 1.3 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein ADIP PF11559.8 EMC87360.1 - 0.056 13.5 8.6 0.11 12.5 8.6 1.5 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Lzipper-MIP1 PF14389.6 EMC87360.1 - 0.31 11.3 9.7 0.036 14.4 2.9 2.9 2 1 1 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 APG6_N PF17675.1 EMC87360.1 - 0.62 10.6 12.7 1.9 9.0 12.7 1.8 1 0 0 1 1 1 0 Apg6 coiled-coil region Auxin_canalis PF05703.11 EMC87360.1 - 0.83 9.5 8.7 1.9 8.3 8.7 1.6 1 0 0 1 1 1 0 Auxin canalisation TPR_MLP1_2 PF07926.12 EMC87360.1 - 1.4 9.0 19.1 2.4 8.2 18.5 1.8 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Spc24 PF08286.11 EMC87360.1 - 1.5 9.1 8.0 3.5 7.9 7.4 1.9 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 OmpH PF03938.14 EMC87360.1 - 2.7 8.4 8.4 6.7 7.1 8.4 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) CENP-Q PF13094.6 EMC87360.1 - 2.8 8.1 12.6 6.4 7.0 12.6 1.6 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit SlyX PF04102.12 EMC87360.1 - 3 8.5 6.8 7.5 7.3 5.7 2.3 2 0 0 2 2 1 0 SlyX Striatin PF08232.12 EMC87360.1 - 3.5 8.2 12.7 3.1 8.4 10.4 2.1 1 1 1 2 2 2 0 Striatin family TMPIT PF07851.13 EMC87360.1 - 3.9 6.6 5.3 6.4 5.9 5.3 1.3 1 0 0 1 1 1 0 TMPIT-like protein Cep57_MT_bd PF06657.13 EMC87360.1 - 5.3 7.6 15.4 0.11 12.9 1.2 2.6 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF4337 PF14235.6 EMC87360.1 - 5.7 7.0 5.6 10 6.2 5.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Tropomyosin_1 PF12718.7 EMC87360.1 - 6.2 7.0 18.1 12 6.0 17.0 1.9 1 1 1 2 2 2 0 Tropomyosin like Beach PF02138.18 EMC87361.1 - 2.4e-116 388.0 0.1 4.1e-116 387.2 0.1 1.3 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 EMC87361.1 - 2.6e-10 40.3 0.3 7.5e-10 38.8 0.3 1.8 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH DUF4704 PF15787.5 EMC87361.1 - 1.5e-09 37.5 1.0 1.5e-09 37.5 1.0 2.9 4 0 0 4 4 4 1 Domain of unknown function (DUF4704) WD40 PF00400.32 EMC87361.1 - 1.1e-06 29.3 18.1 6.5e-05 23.6 0.1 5.6 4 1 0 4 4 4 2 WD domain, G-beta repeat Laminin_G_3 PF13385.6 EMC87361.1 - 0.0025 18.0 0.0 0.011 15.9 0.0 2.0 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily DUF4800 PF16057.5 EMC87361.1 - 0.17 11.2 1.2 0.38 10.0 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4800) V-set PF07686.17 EMC87362.1 - 1e-08 35.3 0.2 2.4e-08 34.1 0.1 1.6 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 EMC87362.1 - 2.8e-06 27.4 0.1 1.5e-05 25.0 0.1 2.2 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC87362.1 - 2.8e-05 24.1 0.0 7.2e-05 22.8 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC87362.1 - 6.4e-05 23.2 0.1 0.004 17.5 0.1 2.7 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC87362.1 - 9.5e-05 22.9 0.0 0.0005 20.6 0.0 2.2 1 1 0 1 1 1 1 Immunoglobulin domain Homeodomain PF00046.29 EMC87364.1 - 6.1e-25 86.8 5.2 1e-24 86.1 5.2 1.4 1 0 0 1 1 1 1 Homeodomain OAR PF03826.17 EMC87364.1 - 2.1e-07 30.5 1.5 2.1e-07 30.5 1.5 2.1 2 0 0 2 2 2 1 OAR domain Homeobox_KN PF05920.11 EMC87364.1 - 0.0033 17.3 0.5 0.016 15.1 0.1 2.1 2 0 0 2 2 2 1 Homeobox KN domain IL8 PF00048.20 EMC87365.1 - 1.5e-08 34.7 1.9 1.9e-08 34.3 1.9 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like DUF1966 PF09260.11 EMC87366.1 - 0.0099 16.1 0.3 6.1 7.2 0.1 2.3 1 1 0 2 2 2 2 Domain of unknown function (DUF1966) IL12p40_C PF10420.9 EMC87366.1 - 0.052 14.1 0.8 3.6 8.2 0.4 2.6 2 1 0 2 2 2 0 Cytokine interleukin-12p40 C-terminus HPIP_like PF18524.1 EMC87366.1 - 0.11 12.2 4.4 0.85 9.4 0.0 3.9 5 0 0 5 5 5 0 High potential iron-sulfur protein like ArgoL1 PF08699.10 EMC87366.1 - 0.54 10.0 7.9 0.81 9.4 0.3 4.0 2 2 2 4 4 4 0 Argonaute linker 1 domain Neuralized PF07177.12 EMC87366.1 - 2 8.4 5.8 15 5.6 0.1 3.3 3 1 0 3 3 3 0 Neuralized ABC1 PF03109.16 EMC87367.1 - 6.1e-14 52.2 0.0 8.9e-14 51.7 0.0 1.2 1 0 0 1 1 1 1 ABC1 family OMPdecase PF00215.24 EMC87369.1 - 4.3e-79 265.2 0.0 6.7e-79 264.6 0.0 1.3 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Pribosyltran PF00156.27 EMC87369.1 - 1.7e-12 47.2 0.0 3.5e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Integrin_beta PF00362.18 EMC87370.1 - 7.9e-110 366.4 0.0 1.2e-109 365.8 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_B_tail PF07965.12 EMC87370.1 - 8.7e-18 64.6 5.6 8.7e-18 64.6 5.6 4.4 3 1 2 5 5 5 1 Integrin beta tail domain Integrin_b_cyt PF08725.11 EMC87370.1 - 6.1e-17 61.0 0.2 6.1e-17 61.0 0.2 1.9 2 0 0 2 2 2 1 Integrin beta cytoplasmic domain PSI_integrin PF17205.3 EMC87370.1 - 9.4e-14 50.9 8.2 9.4e-14 50.9 8.2 4.6 4 0 0 4 4 4 1 Integrin plexin domain I-EGF_1 PF18372.1 EMC87370.1 - 2.7e-09 36.9 9.0 2.7e-09 36.9 9.0 6.0 6 0 0 6 6 6 3 Integrin beta epidermal growth factor like domain 1 EGF_2 PF07974.13 EMC87370.1 - 1.8e-08 34.6 98.2 0.00024 21.4 15.9 6.0 5 1 1 6 6 6 4 EGF-like domain DUF2975 PF11188.8 EMC87370.1 - 0.17 11.8 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) S_locus_glycop PF00954.20 EMC87371.1 - 0.017 15.7 3.4 0.017 15.7 3.4 3.4 3 0 0 3 3 3 0 S-locus glycoprotein domain TMEM154 PF15102.6 EMC87371.1 - 0.043 13.7 0.1 0.12 12.2 0.0 1.8 2 0 0 2 2 2 0 TMEM154 protein family EphA2_TM PF14575.6 EMC87371.1 - 0.047 14.6 0.0 0.1 13.5 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain EGF_CA PF07645.15 EMC87372.1 - 2.5e-07 30.8 29.3 2.5e-07 30.8 5.2 3.8 2 1 2 4 4 4 2 Calcium-binding EGF domain hEGF PF12661.7 EMC87372.1 - 0.00045 20.7 8.1 0.011 16.3 2.0 3.0 2 0 0 2 2 2 2 Human growth factor-like EGF EGF_MSP1_1 PF12946.7 EMC87372.1 - 0.00056 19.9 7.1 0.00056 19.9 7.1 3.4 2 1 1 3 3 3 1 MSP1 EGF domain 1 EGF PF00008.27 EMC87372.1 - 0.00097 19.4 5.5 0.00097 19.4 5.5 2.9 2 0 0 2 2 2 1 EGF-like domain EGF_3 PF12947.7 EMC87372.1 - 0.0021 18.2 21.6 0.0032 17.6 3.7 2.8 3 0 0 3 3 3 2 EGF domain Orthoreo_P10 PF07204.11 EMC87372.1 - 0.033 14.1 0.1 0.089 12.8 0.1 1.7 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 EB PF01683.18 EMC87372.1 - 0.17 12.2 25.6 0.43 10.9 7.2 3.2 2 1 1 3 3 3 0 EB module FXa_inhibition PF14670.6 EMC87372.1 - 1.5 9.1 30.2 0.22 11.9 8.7 3.6 2 1 0 2 2 2 0 Coagulation Factor Xa inhibitory site AA_permease PF00324.21 EMC87373.1 - 4.6e-44 150.8 36.6 4.6e-44 150.8 36.6 2.0 2 0 0 2 2 2 2 Amino acid permease zf-H2C2_2 PF13465.6 EMC87374.1 - 5e-22 77.3 24.1 4.9e-07 29.9 0.7 4.5 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 EMC87374.1 - 3.5e-11 42.9 39.6 0.00069 19.9 1.2 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC87374.1 - 5.6e-09 36.1 35.6 0.025 15.4 1.0 4.8 4 0 0 4 4 4 4 C2H2-type zinc finger RBFA PF02033.18 EMC87374.1 - 0.044 14.2 0.2 0.11 12.9 0.2 1.7 1 0 0 1 1 1 0 Ribosome-binding factor A DZR PF12773.7 EMC87374.1 - 0.51 10.4 8.0 4.1 7.5 1.5 2.4 2 0 0 2 2 2 0 Double zinc ribbon zinc_ribbon_15 PF17032.5 EMC87374.1 - 3.1 8.6 9.5 14 6.5 1.6 2.6 1 1 0 2 2 2 0 zinc-ribbon family zf-C2H2_jaz PF12171.8 EMC87374.1 - 7.8 6.9 17.1 3.1 8.2 2.2 3.9 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding PX PF00787.24 EMC87375.1 - 2.2e-23 82.4 0.1 5.1e-23 81.2 0.1 1.6 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 EMC87375.1 - 1.3e-05 24.9 11.1 0.0029 17.2 11.1 2.2 1 1 0 1 1 1 1 Vps5 C terminal like FlgM PF04316.13 EMC87375.1 - 0.066 13.6 0.2 0.2 12.1 0.2 1.9 1 0 0 1 1 1 0 Anti-sigma-28 factor, FlgM Indigoidine_A PF04227.12 EMC87375.1 - 0.072 12.4 0.2 0.11 11.8 0.2 1.2 1 0 0 1 1 1 0 Indigoidine synthase A like protein Med9 PF07544.13 EMC87375.1 - 0.93 9.6 4.1 4.2 7.5 4.1 2.2 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 ecTbetaR2 PF08917.10 EMC87376.1 - 1.2e-42 144.2 12.1 3.1e-42 143.0 12.1 1.7 1 0 0 1 1 1 1 Transforming growth factor beta receptor 2 ectodomain Pkinase PF00069.25 EMC87376.1 - 2.9e-32 112.1 0.0 4.4e-32 111.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87376.1 - 1.1e-31 110.1 0.0 2.6e-31 108.8 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC87376.1 - 2e-05 23.5 0.0 3.5e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase FixQ PF05545.11 EMC87376.1 - 0.078 13.0 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Oxysterol_BP PF01237.18 EMC87377.1 - 1.9e-59 201.4 9.8 1.9e-43 148.7 0.0 3.1 2 1 0 2 2 2 2 Oxysterol-binding protein PH PF00169.29 EMC87377.1 - 2.8e-12 47.1 0.0 5.4e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 EMC87377.1 - 1.1e-08 35.2 0.0 3.4e-08 33.7 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 EMC87377.1 - 3.1e-05 24.2 0.0 7.3e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 EMC87377.1 - 0.0048 17.2 0.1 0.016 15.6 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_13 PF16652.5 EMC87377.1 - 0.062 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain PH_11 PF15413.6 EMC87377.1 - 0.069 13.6 0.3 1.4 9.3 0.3 2.8 1 1 0 1 1 1 0 Pleckstrin homology domain DUF3565 PF12088.8 EMC87377.1 - 0.28 11.2 2.9 0.95 9.5 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3565) Integrin_B_tail PF07965.12 EMC87377.1 - 2.2 8.8 5.8 0.52 10.8 0.3 2.7 3 0 0 3 3 3 0 Integrin beta tail domain NAD_Gly3P_dh_C PF07479.14 EMC87378.1 - 2.6e-50 170.4 0.3 7.3e-50 168.9 0.3 1.8 3 0 0 3 3 3 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 EMC87378.1 - 1.1e-47 161.9 0.1 4.9e-47 159.8 0.0 2.0 3 0 0 3 3 3 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DUF643 PF04867.12 EMC87378.1 - 0.018 15.6 0.3 0.065 13.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF643) GerD PF17898.1 EMC87378.1 - 0.044 13.7 0.1 0.24 11.4 0.0 2.0 2 0 0 2 2 2 0 Spore germination GerD central core domain KH_1 PF00013.29 EMC87378.1 - 0.14 12.0 3.4 0.2 11.5 0.1 2.9 3 0 0 3 3 3 0 KH domain Peptidase_M8 PF01457.16 EMC87379.1 - 6.4e-67 226.4 6.3 5.2e-64 216.8 4.7 2.9 2 1 0 2 2 2 2 Leishmanolysin WWE PF02825.20 EMC87380.1 - 8.8e-06 26.2 0.1 0.00013 22.5 0.0 2.3 2 0 0 2 2 2 1 WWE domain FidL_like PF15941.5 EMC87380.1 - 0.092 13.2 0.2 1.2 9.6 0.0 2.7 2 1 0 2 2 2 0 FidL-like putative membrane protein LSM PF01423.22 EMC87380.1 - 0.098 12.4 0.2 0.23 11.1 0.2 1.7 1 0 0 1 1 1 0 LSM domain Syntaxin PF00804.25 EMC87380.1 - 0.92 9.1 8.0 0.19 11.4 0.4 2.6 3 0 0 3 3 3 0 Syntaxin RRM_occluded PF16842.5 EMC87381.1 - 0.0013 18.6 0.0 0.0033 17.3 0.0 1.7 1 0 0 1 1 1 1 Occluded RNA-recognition motif NID PF07292.13 EMC87381.1 - 0.023 15.3 0.2 0.77 10.4 0.0 2.9 2 1 0 2 2 2 0 Nmi/IFP 35 domain (NID) Macro PF01661.21 EMC87382.1 - 1.3e-65 218.8 0.4 5.9e-31 106.9 0.0 4.1 3 0 0 3 3 3 3 Macro domain PARP PF00644.20 EMC87382.1 - 2.9e-26 92.3 1.0 1e-25 90.5 1.0 2.0 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.20 EMC87382.1 - 0.00053 20.5 0.1 0.0037 17.8 0.0 2.6 2 0 0 2 2 2 1 WWE domain WGG PF10273.9 EMC87382.1 - 0.0095 16.6 2.4 0.25 12.0 0.3 3.6 2 1 0 2 2 2 1 Pre-rRNA-processing protein TSR2 Svf1_C PF17187.4 EMC87382.1 - 0.074 12.9 0.8 0.28 11.0 0.1 2.4 2 0 0 2 2 2 0 Svf1-like C-terminal lipocalin-like domain DTC PF18102.1 EMC87383.1 - 4.1e-64 214.7 0.2 9.7e-64 213.5 0.2 1.7 1 0 0 1 1 1 1 Deltex C-terminal domain zf-C3HC4_2 PF13923.6 EMC87383.1 - 2.1e-11 43.5 10.8 4.2e-11 42.5 10.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC87383.1 - 4.6e-09 36.5 9.0 1e-08 35.4 9.0 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EMC87383.1 - 3.5e-08 33.2 8.3 7.5e-08 32.1 8.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC87383.1 - 4.8e-07 29.7 4.3 5e-07 29.6 1.4 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EMC87383.1 - 1.1e-06 28.4 11.4 2.4e-06 27.3 11.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC87383.1 - 3.1e-06 27.1 9.7 6.8e-06 25.9 9.7 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EMC87383.1 - 4.1e-05 23.8 5.6 0.00013 22.1 5.6 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EMC87383.1 - 0.00011 22.0 9.7 0.002 18.0 10.2 2.3 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 EMC87383.1 - 0.0018 18.1 2.8 0.004 17.0 2.8 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-UDP PF14569.6 EMC87383.1 - 0.0068 16.5 5.5 0.023 14.8 5.2 2.1 2 0 0 2 2 2 1 Zinc-binding RING-finger zf-C3HC4_4 PF15227.6 EMC87383.1 - 0.0081 16.3 9.1 0.021 15.0 9.1 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Siva PF05458.12 EMC87383.1 - 0.012 15.4 2.3 0.026 14.2 2.3 1.6 1 0 0 1 1 1 0 Cd27 binding protein (Siva) zf-RING_11 PF17123.5 EMC87383.1 - 0.018 14.7 5.1 0.05 13.4 5.1 1.8 1 0 0 1 1 1 0 RING-like zinc finger zf-Nse PF11789.8 EMC87383.1 - 0.038 13.8 5.3 0.1 12.4 5.3 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Glyco_hydro_56 PF01630.18 EMC87383.1 - 0.045 12.7 0.8 0.1 11.6 0.0 1.8 2 0 0 2 2 2 0 Hyaluronidase zf-RING_4 PF14570.6 EMC87383.1 - 0.11 12.3 8.8 0.32 10.8 8.8 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 EMC87383.1 - 0.53 10.5 10.3 0.075 13.2 5.2 2.1 2 0 0 2 2 2 0 zinc RING finger of MSL2 DZR PF12773.7 EMC87383.1 - 0.67 10.0 8.3 1.7 8.7 8.3 1.7 1 0 0 1 1 1 0 Double zinc ribbon zf-P11 PF03854.14 EMC87383.1 - 1.1 8.9 8.5 4 7.2 8.5 1.9 1 1 0 1 1 1 0 P-11 zinc finger ChaB PF06150.12 EMC87383.1 - 1.2 9.7 3.3 20 5.8 0.0 3.0 3 0 0 3 3 3 0 ChaB DUF643 PF04867.12 EMC87383.1 - 1.7 9.3 8.7 0.079 13.6 0.8 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF643) Macro PF01661.21 EMC87384.1 - 4.9e-40 136.3 0.1 3.5e-29 101.2 0.2 2.7 2 0 0 2 2 2 2 Macro domain PARP PF00644.20 EMC87384.1 - 3e-05 23.7 0.1 0.00013 21.6 0.1 2.0 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain FAIM1 PF06905.13 EMC87385.1 - 2.7e-88 294.2 2.9 3.1e-88 294.0 2.9 1.0 1 0 0 1 1 1 1 Fas apoptotic inhibitory molecule (FAIM1) DUF3748 PF12566.8 EMC87385.1 - 0.048 13.6 0.0 0.097 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3748) 5_nucleotid_C PF02872.18 EMC87385.1 - 0.064 13.5 0.1 0.3 11.3 0.0 1.9 1 1 1 2 2 2 0 5'-nucleotidase, C-terminal domain GP88 PF17338.2 EMC87385.1 - 0.094 12.2 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Gene product 88 CBM-like PF14683.6 EMC87385.1 - 0.12 12.2 0.1 0.26 11.2 0.1 1.5 1 1 0 1 1 1 0 Polysaccharide lyase family 4, domain III TMCO5 PF14992.6 EMC87386.1 - 0.0032 17.1 20.8 0.0032 17.1 20.8 2.8 1 1 1 2 2 2 1 TMCO5 family Histidinol_dh PF00815.20 EMC87386.1 - 0.12 11.4 5.6 0.32 9.9 5.6 1.8 1 0 0 1 1 1 0 Histidinol dehydrogenase CoA_transf_3 PF02515.17 EMC87386.1 - 0.13 11.3 3.0 0.4 9.8 3.1 1.7 2 0 0 2 2 2 0 CoA-transferase family III AAA_24 PF13479.6 EMC87386.1 - 1.9 8.2 6.7 14 5.3 0.0 2.9 2 1 0 3 3 3 0 AAA domain Fez1 PF06818.15 EMC87386.1 - 6.8 7.1 37.8 1.3 9.4 20.2 2.9 3 0 0 3 3 3 0 Fez1 DUF365 PF04033.12 EMC87386.1 - 9.2 6.6 7.8 0.46 10.8 0.2 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF365) SMP_LBD PF17047.5 EMC87387.1 - 1.1e-65 220.5 0.3 2.3e-65 219.5 0.3 1.6 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain C2 PF00168.30 EMC87387.1 - 2.1e-51 172.5 0.5 1.4e-22 79.9 0.0 3.5 3 0 0 3 3 3 3 C2 domain TackOD1 PF18551.1 EMC87388.1 - 0.066 12.9 0.1 0.16 11.6 0.1 1.6 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 PapD-like PF14874.6 EMC87389.1 - 3.5e-05 23.9 0.1 5.8e-05 23.2 0.1 1.3 1 0 0 1 1 1 1 Flagellar-associated PapD-like TMEM131_like PF12371.8 EMC87389.1 - 0.00044 20.4 0.0 0.00071 19.8 0.0 1.3 1 0 0 1 1 1 1 Transmembrane protein 131-like ASH PF15780.5 EMC87389.1 - 0.0093 16.2 0.0 0.017 15.3 0.0 1.4 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin 7tm_2 PF00002.24 EMC87390.1 - 4.3e-91 304.6 16.4 6e-91 304.1 16.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 EMC87390.1 - 3.2e-20 72.2 4.4 3.2e-20 72.2 4.4 1.9 2 0 0 2 2 2 1 Hormone receptor domain Insulin_TMD PF17870.1 EMC87390.1 - 0.068 13.2 0.4 0.22 11.6 0.4 1.8 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment TMEM37 PF15108.6 EMC87391.1 - 1.6e-90 301.9 14.6 1.8e-90 301.7 14.6 1.0 1 0 0 1 1 1 1 Voltage-dependent calcium channel gamma-like subunit protein family DUF4173 PF13777.6 EMC87391.1 - 1.3 8.4 8.3 0.12 11.7 2.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4173) ACBP PF00887.19 EMC87392.1 - 1.6e-32 111.5 2.2 1.8e-32 111.4 2.2 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein FERM_M PF00373.18 EMC87392.1 - 0.061 13.7 0.2 0.22 11.9 0.0 1.8 2 0 0 2 2 2 0 FERM central domain JmjN PF02375.17 EMC87392.1 - 0.2 11.6 0.5 1.6 8.7 0.2 2.2 2 0 0 2 2 2 0 jmjN domain DUF2340 PF10209.9 EMC87393.1 - 1.6e-44 151.2 0.0 1.8e-44 151.1 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) DUF5049 PF16468.5 EMC87393.1 - 0.25 11.3 0.9 3.1 7.8 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF5049) F420_oxidored PF03807.17 EMC87394.1 - 2.2e-16 60.2 0.1 1.3e-15 57.7 0.0 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Ferric_reduct PF01794.19 EMC87394.1 - 1.5e-13 51.0 6.6 3.9e-13 49.6 3.5 2.3 1 1 1 2 2 2 2 Ferric reductase like transmembrane component NAD_binding_2 PF03446.15 EMC87394.1 - 4.4e-05 23.7 0.0 0.00082 19.6 0.0 2.1 1 1 1 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 EMC87394.1 - 0.0071 15.9 0.0 0.015 14.9 0.0 1.5 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Malt_amylase_C PF16657.5 EMC87394.1 - 0.018 15.2 0.0 5.8 7.1 0.0 2.4 2 0 0 2 2 2 0 Maltogenic Amylase, C-terminal domain 2-Hacid_dh_C PF02826.19 EMC87394.1 - 0.038 13.4 0.0 0.07 12.5 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Cyclophil_like PF04126.13 EMC87394.1 - 0.16 11.8 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 Cyclophilin-like C1q PF00386.21 EMC87395.1 - 1e-12 48.4 0.0 1e-12 48.3 0.0 1.0 1 0 0 1 1 1 1 C1q domain TNF PF00229.18 EMC87395.1 - 0.033 14.1 0.0 0.034 14.1 0.0 1.0 1 0 0 1 1 1 0 TNF(Tumour Necrosis Factor) family Collagen PF01391.18 EMC87396.1 - 6e-40 134.8 127.0 1.4e-09 37.6 28.1 5.3 1 1 4 5 5 5 5 Collagen triple helix repeat (20 copies) SRCR PF00530.18 EMC87396.1 - 2.4e-29 101.8 2.0 4.1e-29 101.0 2.0 1.3 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 EMC87396.1 - 4.5e-07 30.3 0.3 1.2e-06 28.9 0.0 1.8 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 EMC87396.1 - 0.12 12.8 0.0 0.28 11.7 0.0 1.5 1 0 0 1 1 1 0 Hepsin, SRCR domain MHC2-interact PF09307.10 EMC87396.1 - 0.55 10.2 1.9 0.64 10.0 1.2 1.4 1 1 0 1 1 1 0 CLIP, MHC2 interacting Homeodomain PF00046.29 EMC87397.1 - 8e-23 80.0 8.1 1.1e-22 79.6 8.1 1.2 1 0 0 1 1 1 1 Homeodomain Engrail_1_C_sig PF10525.9 EMC87397.1 - 3.6e-20 70.9 0.6 5.7e-20 70.2 0.6 1.3 1 0 0 1 1 1 1 Engrailed homeobox C-terminal signature domain DUF2316 PF10078.9 EMC87397.1 - 0.00031 20.9 1.0 0.00039 20.6 1.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2316) Homeobox_KN PF05920.11 EMC87397.1 - 0.0013 18.6 3.3 0.0031 17.4 3.0 2.0 1 1 0 1 1 1 1 Homeobox KN domain CENP-B_N PF04218.13 EMC87397.1 - 0.018 14.6 0.3 0.018 14.6 0.3 1.7 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain QLQ PF08880.11 EMC87397.1 - 0.037 13.8 1.9 0.079 12.7 1.9 1.6 1 0 0 1 1 1 0 QLQ INSIG PF07281.12 EMC87398.1 - 3e-37 128.3 3.6 3e-36 125.1 3.6 2.1 1 1 0 1 1 1 1 Insulin-induced protein (INSIG) KOG2701 PF09762.9 EMC87399.1 - 1.4e-77 259.9 0.1 1.4e-77 259.9 0.1 4.4 2 1 1 3 3 3 1 Coiled-coil domain-containing protein (DUF2037) DUF4200 PF13863.6 EMC87399.1 - 0.013 15.9 5.2 0.013 15.9 5.2 5.4 5 1 1 6 6 6 0 Domain of unknown function (DUF4200) NPV_P10 PF05531.12 EMC87399.1 - 0.85 10.1 5.8 12 6.5 5.2 3.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.12 EMC87399.1 - 1.3 9.1 10.5 2.8 8.0 6.5 2.9 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus MerR-DNA-bind PF09278.11 EMC87399.1 - 2.4 8.7 19.1 0.3 11.7 2.0 4.2 3 0 0 3 3 3 0 MerR, DNA binding DUF2730 PF10805.8 EMC87399.1 - 4.5 7.4 22.0 0.23 11.6 0.8 4.8 4 1 0 5 5 5 0 Protein of unknown function (DUF2730) 7tm_1 PF00001.21 EMC87400.1 - 1.7e-64 217.7 9.7 2.2e-64 217.3 9.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC87400.1 - 1.4e-06 28.2 6.4 1.4e-06 28.2 6.4 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF2208 PF09973.9 EMC87400.1 - 0.055 13.1 2.6 0.095 12.3 0.0 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) OppC_N PF12911.7 EMC87400.1 - 0.064 13.2 0.2 0.064 13.2 0.2 3.1 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C DEAD PF00270.29 EMC87401.1 - 1.5e-46 158.4 0.1 3.3e-46 157.3 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC87401.1 - 3.2e-24 85.4 0.0 9.4e-23 80.7 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EMC87401.1 - 2.1e-17 63.1 0.3 3.7e-17 62.3 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EMC87401.1 - 2.7e-07 30.7 0.0 4.9e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DPPIV_N PF00930.21 EMC87402.1 - 6.8e-106 354.0 0.4 1e-105 353.4 0.4 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EMC87402.1 - 4.8e-49 166.7 0.0 7.3e-49 166.1 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 EMC87402.1 - 2.4e-06 27.3 0.0 6.9e-06 25.8 0.0 1.6 1 1 0 1 1 1 1 Dienelactone hydrolase family PD40 PF07676.12 EMC87402.1 - 0.00011 22.0 0.2 1.7 8.7 0.0 3.3 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Hydrolase_4 PF12146.8 EMC87402.1 - 0.00018 20.9 0.2 0.18 11.0 0.1 2.3 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Pecanex_C PF05041.15 EMC87402.1 - 0.011 15.3 0.1 0.037 13.6 0.0 1.8 2 0 0 2 2 2 0 Pecanex protein (C-terminus) Peptidase_S15 PF02129.18 EMC87402.1 - 0.069 12.7 0.1 2.2 7.8 0.0 2.6 2 1 1 3 3 3 0 X-Pro dipeptidyl-peptidase (S15 family) BAAT_C PF08840.11 EMC87402.1 - 0.077 12.9 0.8 0.24 11.3 0.3 1.9 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF872 PF05915.12 EMC87402.1 - 0.089 13.0 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) Abhydrolase_3 PF07859.13 EMC87402.1 - 0.092 12.6 0.0 1.3 8.9 0.0 2.3 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EMC87402.1 - 1.4 8.7 4.4 0.53 10.1 0.4 2.2 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase DUF384 PF04064.13 EMC87403.1 - 3.5e-21 74.8 2.0 5.3e-21 74.2 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF384) DUF383 PF04063.14 EMC87403.1 - 3e-18 66.2 0.0 4.1e-14 52.7 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF383) CNRIP1 PF15043.6 EMC87405.1 - 2.2e-68 228.8 0.1 2.4e-68 228.6 0.1 1.0 1 0 0 1 1 1 1 CB1 cannabinoid receptor-interacting protein 1 PH PF00169.29 EMC87406.1 - 7.1e-41 139.0 0.0 2.1e-19 70.0 0.0 2.4 2 0 0 2 2 2 2 PH domain DEP PF00610.21 EMC87406.1 - 3.5e-14 52.6 0.0 6.9e-14 51.7 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH_9 PF15410.6 EMC87406.1 - 3.9e-11 43.4 0.2 5.4e-05 23.5 0.0 2.7 2 1 0 2 2 2 2 Pleckstrin homology domain PH_6 PF15406.6 EMC87406.1 - 6.8e-10 39.2 0.0 3.4e-06 27.3 0.0 2.4 2 0 0 2 2 2 2 Pleckstrin homology domain PH_13 PF16652.5 EMC87406.1 - 6e-06 26.2 0.0 0.092 12.6 0.0 2.2 2 0 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.6 EMC87406.1 - 2.4e-05 24.7 5.7 0.31 11.5 0.4 4.0 2 2 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 EMC87406.1 - 0.0013 19.0 0.2 0.08 13.2 0.0 3.3 2 2 1 3 3 3 1 Pleckstrin homology domain PH_2 PF08458.10 EMC87406.1 - 0.0087 16.4 0.1 0.28 11.5 0.0 2.3 2 0 0 2 2 2 1 Plant pleckstrin homology-like region PH_16 PF17838.1 EMC87406.1 - 0.077 12.8 0.4 6.1 6.7 0.0 2.9 2 1 0 3 3 3 0 PH domain PH_17 PF18012.1 EMC87406.1 - 0.16 11.7 0.0 0.37 10.6 0.0 1.6 1 0 0 1 1 1 0 PH domain F-box-like PF12937.7 EMC87407.1 - 9e-10 38.3 3.3 1.1e-09 38.0 0.1 2.3 1 1 1 2 2 2 1 F-box-like F-box PF00646.33 EMC87407.1 - 0.00069 19.4 0.2 0.00069 19.4 0.2 2.9 2 1 1 3 3 3 1 F-box domain zf-CCHH PF10283.9 EMC87408.1 - 5.3e-25 87.1 16.3 5.2e-13 48.7 2.6 2.4 2 0 0 2 2 2 2 PBZ domain HUN PF08729.10 EMC87408.1 - 0.00078 19.4 7.6 0.0025 17.8 7.6 1.9 1 0 0 1 1 1 1 HPC2 and ubinuclein domain 7tm_1 PF00001.21 EMC87409.1 - 1.2e-46 159.1 23.9 1.5e-46 158.8 23.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC87409.1 - 2e-05 24.1 27.3 2.9e-05 23.6 27.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Filament PF00038.21 EMC87410.1 - 4.3e-25 89.0 48.9 2e-22 80.2 20.3 2.7 3 0 0 3 3 3 2 Intermediate filament protein TPR_MLP1_2 PF07926.12 EMC87410.1 - 0.0018 18.4 10.9 0.0018 18.4 10.9 4.2 3 1 1 4 4 4 1 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 EMC87410.1 - 0.0028 16.6 13.8 0.0028 16.6 13.8 3.1 2 1 0 3 3 3 1 Spc7 kinetochore protein Lectin_N PF03954.14 EMC87410.1 - 0.3 10.8 7.1 0.034 13.9 0.9 2.6 2 1 0 2 2 2 0 Hepatic lectin, N-terminal domain Baculo_PEP_C PF04513.12 EMC87410.1 - 0.59 10.2 10.5 0.24 11.4 1.0 3.2 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus LemA PF04011.12 EMC87410.1 - 0.75 9.6 22.0 0.074 12.9 2.5 3.6 2 1 1 3 3 3 0 LemA family ApoO PF09769.9 EMC87410.1 - 1.7 8.6 8.8 3.1 7.8 0.8 4.3 3 2 2 5 5 5 0 Apolipoprotein O PSI_PsaF PF02507.15 EMC87410.1 - 1.9 8.3 7.8 4.6 7.0 0.8 3.8 3 1 0 3 3 3 0 Photosystem I reaction centre subunit III DUF4337 PF14235.6 EMC87410.1 - 8.2 6.5 23.8 0.028 14.6 5.9 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4337) Peptidase_S8 PF00082.22 EMC87411.1 - 2.2e-42 145.4 2.8 2.8e-42 145.0 2.8 1.1 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 EMC87411.1 - 1.1e-25 89.4 0.1 2.5e-25 88.3 0.1 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain Peptidase_S8_N PF16361.5 EMC87411.1 - 0.11 12.9 0.1 0.24 11.9 0.1 1.5 1 0 0 1 1 1 0 N-terminal of Subtilase family SH3_2 PF07653.17 EMC87412.1 - 2.3e-19 68.8 0.0 3.3e-19 68.3 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EMC87412.1 - 0.0029 17.4 0.0 0.0049 16.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain RRM_1 PF00076.22 EMC87413.1 - 3.6e-27 94.0 0.7 7.6e-15 54.5 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMC87413.1 - 1.2e-08 34.7 0.0 0.0004 20.2 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_5 PF13893.6 EMC87413.1 - 9.2e-08 31.7 0.1 0.0059 16.2 0.1 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_dom-like PF14714.6 EMC87413.1 - 0.045 14.1 0.1 0.38 11.1 0.1 2.4 2 0 0 2 2 2 0 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal DUF1027 PF06265.11 EMC87413.1 - 0.19 11.8 0.6 0.77 9.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1027) Kinesin PF00225.23 EMC87414.1 - 5.3e-111 370.8 0.3 5.3e-111 370.8 0.3 3.6 2 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EMC87414.1 - 1.2e-23 83.7 0.0 1.2e-23 83.7 0.0 3.1 3 0 0 3 3 3 1 Microtubule binding PX PF00787.24 EMC87414.1 - 5.6e-16 58.5 1.0 5.6e-16 58.5 1.0 3.2 2 1 0 2 2 2 1 PX domain Kinesin_assoc PF16183.5 EMC87414.1 - 4.6e-09 36.7 3.7 1.3e-05 25.4 0.2 6.0 2 2 3 6 6 6 2 Kinesin-associated Yop-YscD_cpl PF16697.5 EMC87414.1 - 8.4e-06 26.0 1.0 8.4e-05 22.8 0.0 3.1 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain DUF2326 PF10088.9 EMC87414.1 - 0.0049 16.6 1.4 0.025 14.3 0.0 2.9 2 0 0 2 2 2 1 Uncharacterised protein conserved in bacteria (DUF2326) DUF5109 PF17134.4 EMC87415.1 - 0.48 10.4 2.3 0.66 9.9 0.3 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF5109) RAP1 PF07218.11 EMC87415.1 - 2.9 6.0 7.9 3.7 5.7 7.9 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) TPR_1 PF00515.28 EMC87416.1 - 8.5e-45 148.8 14.0 1.2e-09 37.5 0.2 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC87416.1 - 7.2e-32 109.5 26.3 9.9e-23 80.2 5.3 5.4 3 1 3 6 6 6 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 EMC87416.1 - 1.4e-31 106.1 14.9 6.4e-06 25.9 0.1 9.6 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_8 PF13181.6 EMC87416.1 - 1.2e-27 93.8 11.2 0.00014 21.8 0.2 9.4 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_12 PF13424.6 EMC87416.1 - 1.3e-26 92.7 5.0 2.9e-07 30.7 0.0 7.0 6 1 0 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 EMC87416.1 - 1.7e-23 82.0 14.0 1e-05 25.1 0.1 8.5 4 2 5 9 9 8 5 TPR repeat TPR_17 PF13431.6 EMC87416.1 - 1.6e-21 75.0 9.2 0.043 14.2 0.0 9.5 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.6 EMC87416.1 - 3.6e-19 69.0 5.7 0.016 15.7 0.0 7.7 5 1 3 8 8 8 6 Tetratricopeptide repeat TPR_16 PF13432.6 EMC87416.1 - 2.8e-18 66.3 0.0 5.4e-07 30.2 0.0 6.1 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 EMC87416.1 - 8.5e-16 57.3 0.1 0.011 16.5 0.0 8.5 4 1 4 9 9 9 2 Tetratricopeptide repeat TPR_6 PF13174.6 EMC87416.1 - 1.5e-12 47.3 11.2 0.17 12.6 0.0 8.2 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.6 EMC87416.1 - 9.6e-11 41.7 0.0 0.0004 20.5 0.0 4.5 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMC87416.1 - 2.1e-06 27.3 2.8 4.2 7.6 0.0 7.3 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_15 PF13429.6 EMC87416.1 - 5.9e-05 22.4 0.0 1.1 8.4 0.0 4.5 3 1 1 4 4 4 1 Tetratricopeptide repeat ChAPs PF09295.10 EMC87416.1 - 7.1e-05 22.0 1.5 0.068 12.2 0.0 2.3 1 1 1 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_MalT PF17874.1 EMC87416.1 - 9.3e-05 21.9 0.3 0.11 11.8 0.0 3.3 2 1 1 3 3 3 1 MalT-like TPR region TPR_20 PF14561.6 EMC87416.1 - 0.014 15.7 0.4 0.13 12.6 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 EMC87416.1 - 0.017 15.0 3.3 4.9 7.2 0.0 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_21 PF09976.9 EMC87416.1 - 0.021 14.6 0.1 0.65 9.7 0.0 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat-like domain Cas_Cas02710 PF09670.10 EMC87416.1 - 0.032 13.0 0.3 0.11 11.2 0.0 2.0 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Cas02710) SRP_TPR_like PF17004.5 EMC87416.1 - 0.082 12.9 7.3 6.9 6.7 0.3 3.8 3 1 1 4 4 4 0 Putative TPR-like repeat DUF2225 PF09986.9 EMC87416.1 - 5.2 6.7 8.6 1.8 8.2 0.1 3.3 2 1 1 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_3 PF07720.12 EMC87416.1 - 6.2 6.9 11.6 13 5.9 1.4 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat PEHE PF15275.6 EMC87417.1 - 1.6e-37 129.0 4.4 1.6e-37 129.0 4.4 3.8 3 0 0 3 3 3 1 PEHE domain Tubulin-binding PF00418.19 EMC87418.1 - 1.1e-60 201.3 28.4 2.6e-16 59.3 1.7 5.4 5 0 0 5 5 5 5 Tau and MAP protein, tubulin-binding repeat Tmemb_cc2 PF10267.9 EMC87418.1 - 0.016 14.4 3.7 0.34 10.0 0.5 2.1 1 1 1 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein Mito_carr PF00153.27 EMC87419.1 - 2.2e-42 142.9 0.0 1.7e-17 63.1 0.0 4.1 4 0 0 4 4 4 4 Mitochondrial carrier protein RIIa PF02197.17 EMC87419.1 - 0.14 11.8 0.9 0.29 10.8 0.9 1.5 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit RUN PF02759.19 EMC87420.1 - 1.6e-23 83.2 0.0 3.6e-23 82.0 0.0 1.6 2 0 0 2 2 2 1 RUN domain DUF5595 PF18077.1 EMC87420.1 - 0.26 11.4 2.2 0.27 11.3 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) HMG_box_5 PF14887.6 EMC87421.1 - 3.2e-52 174.5 17.2 3.9e-50 167.8 5.5 6.1 5 2 2 7 7 7 3 HMG (high mobility group) box 5 HMG_box PF00505.19 EMC87421.1 - 8.3e-49 163.9 72.3 6.6e-18 64.9 7.5 8.4 6 1 1 7 7 7 5 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC87421.1 - 4.6e-21 75.2 68.7 2.7e-08 34.3 0.2 8.2 7 1 1 8 8 8 5 HMG-box domain Evf PF18270.1 EMC87421.1 - 0.054 12.9 0.4 0.31 10.5 0.1 2.1 1 1 1 2 2 2 0 Virulence factor Evf ScsC_N PF18312.1 EMC87421.1 - 0.06 13.2 0.9 0.18 11.6 0.9 1.9 1 0 0 1 1 1 0 Copper resistance protein ScsC N-terminal domain Ins134_P3_kin_N PF17927.1 EMC87421.1 - 0.073 13.5 2.5 6.1 7.3 0.1 3.1 2 1 0 2 2 2 0 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain Chlor_dismutase PF06778.12 EMC87421.1 - 0.16 11.5 0.1 0.16 11.5 0.1 3.1 3 0 0 3 3 3 0 Chlorite dismutase GIDA PF01134.22 EMC87421.1 - 9.8 5.1 7.2 1.8 7.5 0.2 2.8 3 0 0 3 3 3 0 Glucose inhibited division protein A DUF4539 PF15072.6 EMC87422.1 - 2.2e-18 66.1 0.0 2.2e-12 46.8 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4539) Glyco_hydro_31 PF01055.26 EMC87423.1 - 4.4e-85 286.5 3.2 4e-49 168.0 0.1 2.0 2 0 0 2 2 2 2 Glycosyl hydrolases family 31 MFS_1 PF07690.16 EMC87424.1 - 7.6e-14 51.4 32.5 3.8e-13 49.1 24.5 3.0 2 1 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EMC87424.1 - 8.5e-07 27.9 22.8 1.4e-06 27.2 3.0 2.7 3 0 0 3 3 3 2 MFS/sugar transport protein PUCC PF03209.15 EMC87424.1 - 0.0015 17.6 0.7 0.0015 17.6 0.7 2.1 2 0 0 2 2 2 1 PUCC protein DUF553 PF04473.12 EMC87424.1 - 0.11 12.0 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Transglutaminase-like domain zf-C2H2 PF00096.26 EMC87425.1 - 1.8e-14 53.3 20.3 4.5e-05 23.7 0.3 3.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC87425.1 - 4.9e-12 45.7 7.0 8.9e-08 32.2 0.8 3.9 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC87425.1 - 2.7e-08 34.0 19.7 0.014 16.2 0.5 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger FOXP-CC PF16159.5 EMC87425.1 - 0.00038 21.0 8.5 0.24 12.0 3.0 2.9 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-met PF12874.7 EMC87425.1 - 0.12 12.9 8.7 0.18 12.3 1.4 2.8 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 EMC87425.1 - 0.56 10.0 11.3 2.2 8.1 0.2 3.4 3 0 0 3 3 3 0 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 EMC87425.1 - 2.3 8.4 4.6 14 5.9 0.1 3.4 3 1 0 3 3 3 0 Zinc ribbon domain zf-C2H2_jaz PF12171.8 EMC87425.1 - 2.5 8.5 7.9 2.4 8.6 0.7 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-CGNR PF11706.8 EMC87425.1 - 5.8 6.9 8.1 6.6 6.7 0.2 2.6 2 1 0 2 2 2 0 CGNR zinc finger zf-LYAR PF08790.11 EMC87425.1 - 9 6.3 6.0 26 4.8 0.3 3.0 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger Ets PF00178.22 EMC87426.1 - 5e-36 123.0 1.8 8.1e-36 122.3 1.8 1.3 1 0 0 1 1 1 1 Ets-domain CCDC24 PF15669.5 EMC87426.1 - 0.12 12.3 0.8 0.25 11.2 0.8 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family MFS_1 PF07690.16 EMC87427.1 - 7.2e-09 35.0 42.1 6.4e-05 22.0 26.7 2.8 1 1 0 2 2 2 2 Major Facilitator Superfamily GLTT PF01744.20 EMC87428.1 - 2.6e-16 58.9 8.4 0.0045 16.7 0.6 5.4 2 2 2 5 5 5 5 GLTT repeat (6 copies) Pentapeptide_2 PF01469.18 EMC87428.1 - 6.8e-07 29.1 6.1 0.0087 15.9 0.1 3.5 2 1 1 3 3 3 3 Pentapeptide repeats (8 copies) Lamprin PF06403.11 EMC87428.1 - 0.0017 18.3 16.2 4e+02 0.9 16.2 3.0 1 1 0 1 1 1 0 Lamprin Pentapeptide_4 PF13599.6 EMC87428.1 - 0.058 13.6 0.1 0.8 9.9 0.0 2.0 2 0 0 2 2 2 0 Pentapeptide repeats (9 copies) DUF2960 PF11173.8 EMC87428.1 - 2.7 8.5 13.3 8 7.0 0.2 5.3 1 1 5 6 6 6 0 Protein of unknown function (DUF2960) Kelch_1 PF01344.25 EMC87429.1 - 6.2e-44 147.4 1.9 5.9e-10 38.6 0.0 7.1 7 0 0 7 7 7 7 Kelch motif Kelch_6 PF13964.6 EMC87429.1 - 9.9e-33 111.4 1.1 1e-07 31.9 0.0 7.1 4 3 3 7 7 7 7 Kelch motif Kelch_2 PF07646.15 EMC87429.1 - 3.6e-18 64.8 0.1 4.8e-05 23.2 0.0 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 EMC87429.1 - 4.6e-17 61.7 0.3 5.5e-06 26.3 0.0 6.3 6 1 1 7 7 7 4 Galactose oxidase, central domain Kelch_3 PF13415.6 EMC87429.1 - 1.2e-16 60.5 0.2 0.00097 19.4 0.1 5.9 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC87429.1 - 5.6e-05 23.0 1.9 2 8.5 0.0 5.2 6 0 0 6 6 6 1 Kelch motif WYL_2 PF10902.8 EMC87429.1 - 0.0068 16.8 0.1 4.7 7.6 0.0 3.4 4 0 0 4 4 4 1 WYL_2, Sm-like SH3 beta-barrel fold Pkinase PF00069.25 EMC87430.1 - 2.2e-76 256.7 0.1 3.1e-76 256.2 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87430.1 - 8.4e-44 149.8 0.0 1.2e-43 149.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC87430.1 - 7.4e-07 28.8 0.0 1.2e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EMC87430.1 - 8.8e-07 28.2 0.8 1.4e-06 27.5 0.8 1.3 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 EMC87430.1 - 7.5e-06 25.7 0.4 1.3e-05 24.9 0.4 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 EMC87430.1 - 0.00011 21.7 0.3 0.00019 20.9 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMC87430.1 - 0.0021 18.0 0.0 0.0043 17.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 EMC87430.1 - 0.017 14.8 1.1 4.8 6.7 0.2 2.4 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Tmemb_cc2 PF10267.9 EMC87431.1 - 2.7e-178 593.2 7.7 4e-178 592.6 7.7 1.2 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein LMBR1 PF04791.16 EMC87431.1 - 0.00025 20.1 4.5 0.0012 17.8 0.6 2.1 2 0 0 2 2 2 1 LMBR1-like membrane protein TraG_N PF07916.11 EMC87431.1 - 0.00086 18.3 0.4 0.0021 17.0 0.4 1.5 1 0 0 1 1 1 1 TraG-like protein, N-terminal region 7TMR-HDED PF07697.11 EMC87431.1 - 0.0017 18.5 12.3 0.19 11.8 0.2 2.3 2 0 0 2 2 2 2 7TM-HD extracellular Exonuc_VII_L PF02601.15 EMC87431.1 - 0.0026 17.4 16.2 0.17 11.5 0.5 2.2 2 0 0 2 2 2 2 Exonuclease VII, large subunit AI-2E_transport PF01594.16 EMC87431.1 - 0.017 14.3 5.8 5.2 6.1 0.0 2.9 3 0 0 3 3 3 0 AI-2E family transporter DUF1479 PF07350.12 EMC87431.1 - 0.056 12.2 4.5 0.12 11.1 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1479) DUF2313 PF10076.9 EMC87431.1 - 0.074 12.9 5.3 0.047 13.6 0.6 2.4 2 0 0 2 2 2 0 Uncharacterised protein conserved in bacteria (DUF2313) Atg14 PF10186.9 EMC87431.1 - 0.076 12.1 20.8 0.061 12.4 4.4 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Prominin PF05478.11 EMC87431.1 - 0.097 10.6 20.7 0.12 10.3 10.4 2.4 2 1 0 2 2 2 0 Prominin CorA PF01544.18 EMC87431.1 - 0.48 9.7 13.5 0.42 9.9 3.8 2.7 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein Lipoprotein_20 PF13942.6 EMC87431.1 - 0.56 10.1 17.4 1.1 9.1 1.7 2.5 2 1 0 2 2 2 0 YfhG lipoprotein UPF0565 PF10561.9 EMC87431.1 - 0.83 8.8 5.8 0.18 11.0 0.3 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0565 Baculo_PEP_C PF04513.12 EMC87431.1 - 1 9.4 13.7 0.053 13.6 1.5 3.5 2 2 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus GET2 PF08690.10 EMC87431.1 - 1.9 8.1 10.4 0.079 12.6 0.2 2.6 2 1 0 2 2 2 0 GET complex subunit GET2 DUF4131 PF13567.6 EMC87431.1 - 2.3 7.8 3.9 4.6 6.9 3.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF1690 PF07956.11 EMC87431.1 - 2.5 8.5 23.1 6 7.3 5.8 2.6 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) AAA_11 PF13086.6 EMC87431.1 - 3.3 7.4 11.5 1.5 8.5 1.6 2.3 2 0 0 2 2 2 0 AAA domain OmpH PF03938.14 EMC87431.1 - 5.3 7.4 36.8 28 5.1 18.5 3.4 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) CortBP2 PF09727.9 EMC87431.1 - 8.3 6.3 28.0 0.47 10.3 14.8 2.5 2 0 0 2 2 2 0 Cortactin-binding protein-2 Archease PF01951.16 EMC87432.1 - 0.058 13.6 0.0 0.72 10.1 0.0 2.3 1 1 1 2 2 2 0 Archease protein family (MTH1598/TM1083) DUF4524 PF15025.6 EMC87432.1 - 0.57 9.9 3.3 2.4 7.9 0.2 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4524) Pkinase PF00069.25 EMC87433.1 - 1.7e-37 129.2 0.0 2.3e-37 128.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87433.1 - 2e-36 125.6 0.0 2.6e-36 125.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC87433.1 - 1.2e-05 24.3 0.0 1.6e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EMC87433.1 - 3.9e-05 23.1 0.0 5.2e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EMC87433.1 - 0.00031 19.8 0.0 0.00043 19.3 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EMC87433.1 - 0.00062 19.2 0.1 0.00096 18.6 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMC87433.1 - 0.11 12.4 0.0 0.11 12.4 0.0 2.6 3 1 0 3 3 3 0 Phosphotransferase enzyme family WD40 PF00400.32 EMC87434.1 - 1.1e-10 41.9 17.2 0.00038 21.2 2.0 6.2 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC87434.1 - 3.3e-09 36.9 0.7 0.027 14.8 0.0 4.0 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 EMC87434.1 - 0.13 10.5 0.1 0.21 9.9 0.1 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz BUD22 PF09073.10 EMC87434.1 - 2.3 7.5 11.9 3.5 6.9 11.9 1.2 1 0 0 1 1 1 0 BUD22 ig PF00047.25 EMC87435.1 - 0.0002 21.4 0.0 0.00066 19.8 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 EMC87435.1 - 0.00052 20.2 0.0 0.0078 16.4 0.0 2.2 1 1 1 2 2 2 1 Immunoglobulin V-set domain Ig_6 PF18452.1 EMC87435.1 - 0.0016 18.0 0.0 0.0033 16.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC87435.1 - 0.0031 18.1 0.0 0.0085 16.7 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC87435.1 - 0.0047 17.2 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Izumo-Ig PF16706.5 EMC87435.1 - 0.019 15.0 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain TSP_1 PF00090.19 EMC87435.1 - 0.38 11.0 4.8 0.73 10.1 4.8 1.4 1 0 0 1 1 1 0 Thrombospondin type 1 domain Ig_3 PF13927.6 EMC87436.1 - 1.7e-74 246.4 8.4 4.8e-14 52.7 0.0 7.8 8 0 0 8 8 7 6 Immunoglobulin domain I-set PF07679.16 EMC87436.1 - 5.5e-72 237.9 0.0 3.1e-13 49.6 0.0 6.7 6 0 0 6 6 6 6 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC87436.1 - 2.4e-50 168.8 0.0 1.1e-09 38.5 0.0 6.8 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.25 EMC87436.1 - 1.2e-45 153.6 2.0 3.6e-09 36.7 0.0 7.8 7 0 0 7 7 6 6 Immunoglobulin domain fn3 PF00041.21 EMC87436.1 - 1e-42 144.4 17.5 5.3e-12 45.9 0.1 6.0 5 0 0 5 5 5 5 Fibronectin type III domain Bravo_FIGEY PF13882.6 EMC87436.1 - 1.3e-26 93.8 5.9 3.5e-26 92.4 5.9 1.8 1 0 0 1 1 1 1 Bravo-like intracellular region V-set PF07686.17 EMC87436.1 - 5.4e-16 58.7 5.1 0.00055 20.1 0.0 9.8 7 4 2 9 9 9 2 Immunoglobulin V-set domain Ig_6 PF18452.1 EMC87436.1 - 1.9e-09 36.9 0.0 0.16 11.5 0.0 6.0 6 0 0 6 6 6 2 Immunoglobulin domain Ig_5 PF16681.5 EMC87436.1 - 1.9e-08 34.6 0.0 0.03 14.7 0.0 5.3 6 1 0 6 6 5 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 EMC87436.1 - 1.4e-07 31.6 2.6 0.98 9.7 0.0 6.4 6 1 0 6 6 6 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 EMC87436.1 - 1.6e-06 28.1 15.8 0.17 12.0 0.0 7.1 8 1 0 8 8 5 2 CD80-like C2-set immunoglobulin domain BiPBP_C PF06832.12 EMC87436.1 - 0.00038 20.4 0.1 0.39 10.8 0.0 4.8 6 0 0 6 6 6 1 Penicillin-Binding Protein C-terminus Family Izumo-Ig PF16706.5 EMC87436.1 - 0.00088 19.3 0.0 8.9 6.4 0.0 4.5 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain CrgA PF06781.12 EMC87436.1 - 0.16 12.0 0.0 0.63 10.1 0.0 2.0 1 0 0 1 1 1 0 Cell division protein CrgA Frag1 PF10277.9 EMC87437.1 - 4.9e-47 160.3 18.1 5.8e-47 160.0 18.1 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family TMEM70 PF06979.12 EMC87437.1 - 0.011 16.1 4.0 0.054 13.9 0.8 2.5 2 1 0 2 2 2 0 Assembly, mitochondrial proton-transport ATP synth complex TssN PF17555.2 EMC87437.1 - 0.41 10.0 10.9 0.75 9.1 10.9 1.5 1 0 0 1 1 1 0 Type VI secretion system, TssN CDP-OH_P_transf PF01066.21 EMC87438.1 - 2.8e-19 69.7 0.1 2.8e-19 69.7 0.1 1.6 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Methyltransf_9 PF08003.11 EMC87438.1 - 0.23 10.3 0.1 0.36 9.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) DENN PF02141.21 EMC87439.1 - 1.3e-56 191.5 2.6 2.4e-56 190.6 2.6 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 EMC87439.1 - 6e-16 58.9 0.1 1.3e-15 57.9 0.1 1.6 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 EMC87439.1 - 1.2e-09 38.0 0.5 2.6e-09 36.9 0.5 1.5 1 0 0 1 1 1 1 dDENN domain SPA PF08616.10 EMC87439.1 - 0.13 12.2 0.1 0.25 11.3 0.1 1.4 1 0 0 1 1 1 0 Stabilization of polarity axis Basic PF01586.16 EMC87440.1 - 4.4e-31 107.9 0.0 1.1e-30 106.6 0.0 1.7 1 0 0 1 1 1 1 Myogenic Basic domain Glyco_transf_54 PF04666.13 EMC87441.1 - 8.4e-82 274.3 0.0 1.2e-81 273.8 0.0 1.2 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Tmemb_9 PF05434.11 EMC87442.1 - 9.9e-33 113.1 8.9 1.9e-16 60.3 0.7 2.3 2 0 0 2 2 2 2 TMEM9 Metal_resist PF13801.6 EMC87442.1 - 0.015 15.5 1.1 0.022 15.0 1.1 1.3 1 0 0 1 1 1 0 Heavy-metal resistance fn3 PF00041.21 EMC87443.1 - 4.3e-58 193.6 7.4 1.2e-14 54.4 0.0 4.6 4 0 0 4 4 4 4 Fibronectin type III domain I-set PF07679.16 EMC87443.1 - 1.7e-55 185.1 0.1 7.9e-18 64.3 0.0 6.5 7 0 0 7 7 7 4 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC87443.1 - 1.9e-35 121.3 3.1 9.5e-13 48.6 0.1 6.8 8 0 0 8 8 8 4 Immunoglobulin domain ig PF00047.25 EMC87443.1 - 3.2e-18 65.7 0.0 5.1e-06 26.6 0.0 5.0 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 EMC87443.1 - 2.3e-17 63.1 0.0 8.2e-08 32.5 0.1 4.6 4 0 0 4 4 4 3 Immunoglobulin domain Tissue_fac PF01108.17 EMC87443.1 - 8.2e-14 51.4 0.4 0.0012 18.7 0.0 4.4 4 0 0 4 4 4 3 Tissue factor Pur_ac_phosph_N PF16656.5 EMC87443.1 - 6.6e-12 45.8 10.2 0.021 15.4 0.6 5.7 4 2 0 4 4 4 4 Purple acid Phosphatase, N-terminal domain Receptor_2B4 PF11465.8 EMC87443.1 - 1.7e-09 37.8 0.0 0.00084 19.5 0.0 4.4 4 0 0 4 4 4 2 Natural killer cell receptor 2B4 fn3_4 PF16794.5 EMC87443.1 - 7.3e-08 32.3 0.1 0.23 11.4 0.0 4.9 4 1 0 4 4 4 2 Fibronectin-III type domain DUF2369 PF10179.9 EMC87443.1 - 1.6e-07 31.6 0.0 2.4 8.6 0.0 4.6 4 0 0 4 4 4 2 Uncharacterised conserved protein (DUF2369) V-set PF07686.17 EMC87443.1 - 5.4e-06 26.5 2.2 0.53 10.5 0.0 6.4 6 3 2 8 8 8 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC87443.1 - 0.00012 22.1 0.0 0.15 12.1 0.0 3.8 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain PhoD_N PF16655.5 EMC87443.1 - 0.00016 22.1 0.1 0.53 10.9 0.0 4.0 4 0 0 4 4 4 1 PhoD-like phosphatase, N-terminal domain Y_Y_Y PF07495.13 EMC87443.1 - 0.0049 16.8 1.1 0.57 10.2 0.1 4.2 5 0 0 5 5 4 1 Y_Y_Y domain Reeler PF02014.16 EMC87443.1 - 0.037 14.8 1.2 9.4 7.0 0.0 4.3 4 0 0 4 4 4 0 Reeler domain DUF4959 PF16323.5 EMC87443.1 - 0.041 14.2 0.1 0.36 11.2 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4959) DUF4945 PF16303.5 EMC87443.1 - 0.055 13.4 0.0 0.47 10.4 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4945) Arm PF00514.23 EMC87444.1 - 5.6e-30 102.4 3.8 2.3e-09 37.0 0.0 7.6 9 0 0 9 9 9 5 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EMC87444.1 - 1.8e-06 28.3 3.3 0.062 13.8 0.1 5.1 5 0 0 5 5 5 2 HEAT-like repeat HEAT_2 PF13646.6 EMC87444.1 - 0.0031 17.8 0.5 0.22 11.9 0.1 3.0 2 1 1 3 3 3 1 HEAT repeats HEAT PF02985.22 EMC87444.1 - 0.005 17.0 2.0 2 8.9 0.1 4.1 5 0 0 5 5 5 1 HEAT repeat V-ATPase_H_C PF11698.8 EMC87444.1 - 0.0077 16.3 0.1 0.042 13.9 0.0 2.3 3 0 0 3 3 3 1 V-ATPase subunit H Mo25 PF08569.11 EMC87444.1 - 0.013 14.9 0.1 0.031 13.7 0.0 1.6 2 0 0 2 2 2 0 Mo25-like Adaptin_N PF01602.20 EMC87444.1 - 0.024 13.2 0.9 3.9 5.9 0.0 2.6 1 1 0 2 2 2 0 Adaptin N terminal region Arm_2 PF04826.13 EMC87444.1 - 0.35 10.3 1.4 0.99 8.8 0.1 2.2 2 2 0 2 2 2 0 Armadillo-like Troponin PF00992.20 EMC87445.1 - 1.7e-37 128.7 46.6 1.7e-33 115.8 36.5 2.0 1 1 1 2 2 2 2 Troponin Caldesmon PF02029.15 EMC87447.1 - 2.9e-07 29.6 0.6 2.9e-07 29.6 0.6 1.1 1 0 0 1 1 1 1 Caldesmon Med26_C PF15693.5 EMC87447.1 - 0.08 13.1 0.1 0.085 13.0 0.1 1.2 1 0 0 1 1 1 0 Mediator complex subunit 26 C-terminal Cadherin_tail PF15974.5 EMC87447.1 - 0.098 13.0 0.1 1.1 9.6 0.0 2.1 2 0 0 2 2 2 0 Cadherin C-terminal cytoplasmic tail, catenin-binding region Troponin PF00992.20 EMC87448.1 - 9.3e-49 165.2 8.1 1.3e-48 164.7 8.1 1.2 1 0 0 1 1 1 1 Troponin Tup_N PF08581.10 EMC87448.1 - 0.022 15.1 2.6 0.032 14.5 0.1 2.3 2 0 0 2 2 2 0 Tup N-terminal XkdW PF09636.10 EMC87448.1 - 0.081 13.0 2.5 0.57 10.3 2.5 2.2 1 1 0 1 1 1 0 XkdW protein DUF2951 PF11166.8 EMC87448.1 - 0.43 10.8 5.0 1.2 9.4 2.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2951) Med9 PF07544.13 EMC87448.1 - 0.68 10.1 6.6 11 6.2 1.3 2.9 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 PH_15 PF17339.2 EMC87449.1 - 2.8e-06 27.2 0.1 5.1e-06 26.3 0.1 1.4 1 1 0 1 1 1 1 PH domain PH PF00169.29 EMC87449.1 - 3.1e-05 24.4 0.1 3.8e-05 24.1 0.1 1.1 1 0 0 1 1 1 1 PH domain LIM PF00412.22 EMC87450.1 - 1.1e-29 102.4 24.0 5.8e-17 61.7 5.1 2.1 2 0 0 2 2 2 2 LIM domain zf_UBZ PF18439.1 EMC87450.1 - 0.012 15.2 9.2 1.2 8.8 0.3 3.9 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger TNFR_c6 PF00020.18 EMC87450.1 - 0.31 11.5 15.6 0.51 10.8 0.6 4.2 4 1 1 5 5 5 0 TNFR/NGFR cysteine-rich region zf-ACC PF17848.1 EMC87450.1 - 0.44 10.7 0.2 0.44 10.7 0.2 4.8 6 0 0 6 6 6 0 Acetyl-coA carboxylase zinc finger domain zf-C2H2_12 PF18658.1 EMC87450.1 - 2.7 7.6 7.2 2 8.1 0.6 2.8 3 0 0 3 3 3 0 Zinc-finger C2H2-type Dynactin_p62 PF05502.13 EMC87450.1 - 3.2 6.4 8.8 4.3 6.0 1.3 2.1 2 0 0 2 2 2 0 Dynactin p62 family Zn-ribbon_8 PF09723.10 EMC87450.1 - 4.6 7.5 22.4 0.22 11.6 3.3 3.8 4 0 0 4 4 4 0 Zinc ribbon domain DUF4428 PF14471.6 EMC87450.1 - 5.9 6.9 18.6 0.63 10.0 2.6 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4428) PRKG1_interact PF15898.5 EMC87452.1 - 8.3e-32 110.1 19.7 8.3e-32 110.1 19.7 5.5 6 1 0 6 6 6 1 cGMP-dependent protein kinase interacting domain Ank_4 PF13637.6 EMC87452.1 - 2.4e-27 95.0 0.9 1.2e-12 48.1 0.0 3.8 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC87452.1 - 2.1e-25 89.1 0.5 1.1e-12 48.3 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC87452.1 - 7.8e-24 83.4 1.6 2.3e-09 37.3 0.0 4.4 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EMC87452.1 - 9.6e-21 73.3 4.6 3.7e-06 27.1 0.1 4.6 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 EMC87452.1 - 1.2e-17 62.2 1.8 0.00058 20.1 0.1 5.0 5 0 0 5 5 5 4 Ankyrin repeat FapA PF03961.13 EMC87452.1 - 0.0025 16.5 5.7 0.0025 16.5 5.7 1.9 2 0 0 2 2 2 1 Flagellar Assembly Protein A Golgin_A5 PF09787.9 EMC87452.1 - 0.0027 17.2 8.1 0.0027 17.2 8.1 4.1 4 0 0 4 4 4 1 Golgin subfamily A member 5 C2 PF00168.30 EMC87453.1 - 1.4e-55 186.0 0.3 1.5e-28 99.1 0.0 2.3 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.6 EMC87453.1 - 2.7e-05 23.8 0.0 0.096 12.2 0.0 2.5 1 1 1 2 2 2 2 CEP76 C2 domain MAP17 PF15807.5 EMC87453.1 - 2.9e-05 24.3 0.1 6.9e-05 23.1 0.1 1.6 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 PI3K_C2 PF00792.24 EMC87453.1 - 0.00057 19.8 0.4 0.41 10.6 0.0 2.9 3 0 0 3 3 3 2 Phosphoinositide 3-kinase C2 DOCK-C2 PF14429.6 EMC87453.1 - 0.00066 19.5 0.1 0.75 9.6 0.0 2.4 2 0 0 2 2 2 2 C2 domain in Dock180 and Zizimin proteins TMEM52 PF14979.6 EMC87453.1 - 0.0013 18.6 2.8 0.0025 17.8 2.8 1.4 1 0 0 1 1 1 1 Transmembrane 52 EphA2_TM PF14575.6 EMC87453.1 - 0.011 16.6 0.0 0.025 15.5 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Comm PF15957.5 EMC87453.1 - 0.02 15.2 0.0 0.042 14.2 0.0 1.5 1 0 0 1 1 1 0 Commissureless Transglut_C PF00927.22 EMC87453.1 - 0.04 14.1 0.8 6.8 6.9 0.1 2.4 2 0 0 2 2 2 0 Transglutaminase family, C-terminal ig like domain FAM176 PF14851.6 EMC87453.1 - 0.05 13.3 0.5 0.093 12.4 0.5 1.4 1 0 0 1 1 1 0 FAM176 family DUF4752 PF15944.5 EMC87453.1 - 0.88 9.7 3.5 3.7 7.7 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4752) Prothymosin PF03247.14 EMC87453.1 - 6.5 7.3 15.5 1.3 9.5 8.4 2.6 2 0 0 2 2 2 0 Prothymosin/parathymosin family Trypan_PARP PF05887.11 EMC87454.1 - 0.037 14.0 13.5 0.1 12.6 13.5 1.7 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Peptidase_M1 PF01433.20 EMC87455.1 - 3.6e-49 167.3 0.0 7.6e-49 166.2 0.0 1.6 2 0 0 2 2 2 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 EMC87455.1 - 3.8e-31 107.5 0.4 6.3e-31 106.8 0.4 1.4 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 EMC87455.1 - 7.4e-13 49.1 0.8 1.2e-12 48.4 0.8 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_MA_2 PF13485.6 EMC87455.1 - 0.052 13.2 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 Peptidase MA superfamily Sec7 PF01369.20 EMC87455.1 - 0.12 12.1 0.1 0.43 10.2 0.1 1.8 2 0 0 2 2 2 0 Sec7 domain IBN_N PF03810.19 EMC87456.1 - 5.1e-06 26.3 0.0 2e-05 24.4 0.0 2.1 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EMC87456.1 - 1.6e-05 25.0 2.8 0.0015 18.6 0.0 4.2 4 0 0 4 4 4 1 Exportin 1-like protein RIX1 PF08167.12 EMC87456.1 - 0.019 14.7 8.6 2.8 7.6 0.1 4.9 5 1 0 5 5 5 0 rRNA processing/ribosome biogenesis MutL_C PF08676.11 EMC87456.1 - 0.096 12.4 0.2 1 9.1 0.0 2.7 3 0 0 3 3 3 0 MutL C terminal dimerisation domain UNC45-central PF11701.8 EMC87456.1 - 0.1 12.6 0.3 2.1 8.3 0.1 3.1 2 0 0 2 2 2 0 Myosin-binding striated muscle assembly central PLU-1 PF08429.11 EMC87457.1 - 7.3e-95 318.0 10.1 5.9e-92 308.4 1.4 4.0 4 0 0 4 4 4 2 PLU-1-like protein JmjC PF02373.22 EMC87457.1 - 7.1e-45 152.1 0.7 1.5e-44 151.0 0.7 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.29 EMC87457.1 - 5.8e-26 90.1 36.7 1.1e-11 44.5 4.1 4.3 4 0 0 4 4 4 3 PHD-finger ARID PF01388.21 EMC87457.1 - 1.7e-17 63.8 0.0 4.5e-17 62.5 0.0 1.8 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain zf-C5HC2 PF02928.16 EMC87457.1 - 1.9e-13 50.6 12.1 1.9e-13 50.6 12.1 3.8 3 0 0 3 3 3 1 C5HC2 zinc finger PHD_2 PF13831.6 EMC87457.1 - 0.0053 16.3 28.0 0.07 12.7 5.0 4.0 4 0 0 4 4 4 3 PHD-finger zf-PHD-like PF15446.6 EMC87457.1 - 0.029 14.0 11.4 0.18 11.4 0.4 4.2 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain Kelch_1 PF01344.25 EMC87458.1 - 8.6e-73 239.7 17.0 1e-14 53.8 0.2 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EMC87458.1 - 8.9e-39 130.5 14.8 3.9e-10 39.6 0.0 6.2 2 2 4 6 6 6 6 Kelch motif BACK PF07707.15 EMC87458.1 - 1.1e-34 118.6 0.8 2.2e-34 117.6 0.8 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_2 PF07646.15 EMC87458.1 - 2e-25 87.7 6.1 0.0016 18.3 0.0 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 EMC87458.1 - 4e-25 87.5 9.7 1.3e-07 31.7 0.7 5.4 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_4 PF13418.6 EMC87458.1 - 3.1e-23 81.5 10.9 0.00036 20.5 0.0 6.2 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC87458.1 - 3.4e-13 49.2 10.1 0.019 15.0 0.1 6.0 6 0 0 6 6 6 4 Kelch motif BTB PF00651.31 EMC87458.1 - 2.2e-11 44.0 0.5 4.4e-11 43.0 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain Glu_cyclase_2 PF05096.12 EMC87458.1 - 0.11 12.0 0.0 0.39 10.1 0.0 1.9 1 1 0 1 1 1 0 Glutamine cyclotransferase LRR_8 PF13855.6 EMC87459.1 - 2.4e-81 267.4 49.3 5.4e-16 58.1 0.4 8.3 3 2 5 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 EMC87459.1 - 9.3e-44 146.7 23.5 7.2e-06 26.3 0.7 9.7 6 1 5 11 11 11 11 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC87459.1 - 1e-24 86.9 0.0 1.1e-08 35.1 0.0 4.0 2 1 2 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC87459.1 - 1e-17 64.2 10.0 0.00014 21.4 0.8 4.7 1 1 4 5 5 5 5 Leucine-rich repeat LRR_1 PF00560.33 EMC87459.1 - 5.1e-13 47.6 33.8 6.1 7.8 0.2 13.3 11 2 1 12 12 12 4 Leucine Rich Repeat LRRNT PF01462.18 EMC87459.1 - 1.5e-05 24.5 1.5 5e-05 22.8 1.5 2.0 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 EMC87459.1 - 0.0032 17.4 41.4 0.33 11.1 0.0 10.7 13 0 0 13 13 13 4 Leucine Rich repeat 7tm_1 PF00001.21 EMC87459.1 - 0.015 14.7 14.1 0.22 10.8 14.1 2.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Y_phosphatase PF00102.27 EMC87460.1 - 1e-70 237.9 0.0 1.3e-70 237.6 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EMC87460.1 - 0.00017 21.4 0.0 0.00039 20.2 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC87460.1 - 0.0023 18.0 0.0 0.004 17.1 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Arf PF00025.21 EMC87461.1 - 4.9e-39 133.6 0.1 5.8e-39 133.3 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EMC87461.1 - 3.7e-14 52.6 0.0 4.1e-14 52.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC87461.1 - 7.6e-11 42.3 0.0 1.3e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EMC87461.1 - 7.7e-07 28.7 0.0 8.9e-07 28.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EMC87461.1 - 1.6e-05 24.3 0.0 2.1e-05 23.9 0.0 1.3 1 1 0 1 1 1 1 G-protein alpha subunit SRPRB PF09439.10 EMC87461.1 - 0.00083 18.8 0.0 0.00097 18.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EMC87461.1 - 0.0056 16.7 0.0 0.015 15.4 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase 7tm_1 PF00001.21 EMC87462.1 - 7.4e-18 64.8 12.5 9.4e-18 64.5 12.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PDR_CDR PF06422.12 EMC87462.1 - 0.045 13.7 0.5 0.19 11.7 0.1 2.1 2 0 0 2 2 2 0 CDR ABC transporter Ets PF00178.22 EMC87463.1 - 6e-31 106.7 1.3 1.1e-30 105.9 1.3 1.5 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.16 EMC87463.1 - 1.4e-17 63.4 0.0 5.6e-17 61.5 0.0 2.0 3 0 0 3 3 3 1 Sterile alpha motif (SAM)/Pointed domain AT_hook PF02178.19 EMC87463.1 - 0.16 11.9 5.1 0.38 10.8 5.1 1.7 1 0 0 1 1 1 0 AT hook motif Lys PF00062.20 EMC87465.1 - 3.1e-46 156.7 2.3 3.5e-46 156.5 2.3 1.0 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family SLT PF01464.20 EMC87465.1 - 0.015 14.9 0.0 0.022 14.4 0.0 1.2 1 0 0 1 1 1 0 Transglycosylase SLT domain Destabilase PF05497.12 EMC87465.1 - 0.027 14.8 2.1 0.04 14.3 2.1 1.4 1 0 0 1 1 1 0 Destabilase 7tm_4 PF13853.6 EMC87466.1 - 3.1e-49 168.2 11.1 4e-49 167.8 11.1 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC87466.1 - 2e-31 109.3 12.3 3.4e-31 108.5 12.3 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC87466.1 - 0.0001 21.8 11.8 0.00019 20.9 11.8 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Baculo_11_kDa PF06143.11 EMC87466.1 - 0.028 14.0 2.1 0.075 12.6 2.1 1.7 1 0 0 1 1 1 0 Baculovirus 11 kDa family DCX PF03607.17 EMC87469.1 - 6.8e-32 109.4 0.0 2.8e-20 72.1 0.0 2.2 2 0 0 2 2 2 2 Doublecortin Sox17_18_mid PF12067.8 EMC87470.1 - 3.8e-20 71.6 4.5 1.2e-19 70.1 4.5 1.8 1 0 0 1 1 1 1 Sox 17/18 central domain G-patch PF01585.23 EMC87470.1 - 2.1e-16 59.5 3.9 3.6e-16 58.8 3.9 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EMC87470.1 - 2.9e-08 33.7 1.5 2.9e-08 33.7 1.5 1.9 2 0 0 2 2 2 1 G-patch domain HMG_box PF00505.19 EMC87470.1 - 1.8e-06 28.2 3.9 3.9e-06 27.2 3.9 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC87470.1 - 0.012 16.2 0.8 0.03 14.9 0.8 1.8 1 1 0 1 1 1 0 HMG-box domain DUF3437 PF11919.8 EMC87470.1 - 1 9.4 3.3 3.6 7.6 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3437) XK-related PF09815.9 EMC87472.1 - 1.8e-100 336.4 21.3 2.1e-100 336.1 21.3 1.0 1 0 0 1 1 1 1 XK-related protein ECF_trnsprt PF12822.7 EMC87472.1 - 0.13 12.3 8.4 0.25 11.4 8.4 1.5 1 0 0 1 1 1 0 ECF transporter, substrate-specific component DUF5538 PF17692.1 EMC87473.1 - 0.00095 19.2 0.2 0.0011 19.0 0.2 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5538) Meleagrin PF08189.11 EMC87474.1 - 1e-13 50.7 16.8 1.3e-13 50.4 16.8 1.2 1 0 0 1 1 1 1 Meleagrin/Cygnin family DIM PF08194.12 EMC87474.1 - 0.054 13.7 0.8 0.078 13.2 0.1 1.7 2 0 0 2 2 2 0 DIM protein DUF2116 PF09889.9 EMC87474.1 - 4.1 7.5 7.2 10 6.2 1.6 2.2 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Meleagrin PF08189.11 EMC87475.1 - 1.6e-08 34.1 9.1 2.2e-08 33.6 9.1 1.3 1 0 0 1 1 1 1 Meleagrin/Cygnin family Meleagrin PF08189.11 EMC87476.1 - 3.1e-12 46.0 15.9 4.1e-12 45.6 15.9 1.1 1 0 0 1 1 1 1 Meleagrin/Cygnin family Nodulin_late PF07127.11 EMC87476.1 - 0.09 13.1 6.5 3.2 8.2 6.8 2.2 1 1 1 2 2 2 0 Late nodulin protein Myotub-related PF06602.14 EMC87477.1 - 8.6e-135 449.2 0.7 1.1e-134 448.9 0.7 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.20 EMC87477.1 - 0.0016 18.3 0.0 0.0037 17.1 0.0 1.5 1 0 0 1 1 1 1 GRAM domain Hydrolase_6 PF13344.6 EMC87477.1 - 0.05 13.7 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase 3-PAP PF12578.8 EMC87477.1 - 0.1 12.3 3.1 0.5 10.1 3.1 2.0 1 1 0 1 1 1 0 Myotubularin-associated protein Epimerase PF01370.21 EMC87478.1 - 1.5e-22 80.2 0.0 9.1e-22 77.7 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMC87478.1 - 2.3e-15 56.8 0.0 1.6e-14 54.1 0.0 2.0 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EMC87478.1 - 1.6e-07 30.8 0.0 2.5e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 EMC87478.1 - 2e-06 27.1 0.0 2.9e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EMC87478.1 - 4e-06 26.2 0.5 2.3e-05 23.7 0.0 2.3 2 1 0 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.15 EMC87478.1 - 0.00067 18.9 0.1 0.006 15.7 0.1 2.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 EMC87478.1 - 0.053 13.4 0.1 0.14 12.0 0.0 1.6 2 0 0 2 2 2 0 KR domain FAM167 PF11652.8 EMC87479.1 - 4.1e-38 129.7 2.2 8.9e-38 128.7 2.2 1.6 1 0 0 1 1 1 1 FAM167 LURAP PF14854.6 EMC87479.1 - 0.0028 17.6 0.5 0.0057 16.6 0.3 1.6 2 0 0 2 2 2 1 Leucine rich adaptor protein CEP209_CC5 PF16574.5 EMC87479.1 - 0.028 14.6 3.4 0.3 11.3 0.3 2.2 2 0 0 2 2 2 0 Coiled-coil region of centrosome protein CE290 DUF2388 PF09498.10 EMC87479.1 - 0.052 13.5 0.1 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2388) ERM PF00769.19 EMC87479.1 - 0.22 11.3 6.6 0.82 9.4 6.6 2.0 1 1 0 1 1 1 0 Ezrin/radixin/moesin family DUF4530 PF15039.6 EMC87479.1 - 1.7 8.8 6.7 0.18 12.0 1.6 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4530) Dapper PF15268.6 EMC87479.1 - 4.9 5.9 7.4 7.7 5.2 7.4 1.5 1 1 0 1 1 1 0 Dapper DUF4404 PF14357.6 EMC87479.1 - 9.1 7.0 7.9 6 7.6 4.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) Pkinase_Tyr PF07714.17 EMC87480.1 - 2.7e-94 315.3 0.0 3.5e-94 314.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC87480.1 - 1.9e-46 158.6 0.0 2.7e-46 158.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 EMC87480.1 - 1.6e-26 92.2 0.1 2.9e-26 91.4 0.1 1.4 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 EMC87480.1 - 5.9e-15 54.6 0.0 1.4e-14 53.4 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC87480.1 - 1.8e-09 37.3 0.0 3.9e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC87480.1 - 1.3e-07 31.2 0.1 3.9e-07 29.6 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_16 PF18348.1 EMC87480.1 - 0.0037 17.0 0.0 0.0075 16.1 0.0 1.5 1 0 0 1 1 1 1 Bacterial dipeptidyl-peptidase Sh3 domain Haspin_kinase PF12330.8 EMC87480.1 - 0.008 15.2 0.1 0.012 14.6 0.1 1.4 1 1 0 1 1 1 1 Haspin like kinase domain SH3_3 PF08239.11 EMC87480.1 - 0.014 15.7 0.0 0.037 14.3 0.0 1.7 1 0 0 1 1 1 0 Bacterial SH3 domain Kdo PF06293.14 EMC87480.1 - 0.13 11.6 0.1 0.3 10.4 0.1 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SRCR PF00530.18 EMC87481.1 - 3.6e-126 412.5 54.6 1.6e-29 102.3 6.0 5.2 5 0 0 5 5 5 5 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 EMC87481.1 - 1.2e-14 54.7 21.8 0.0084 16.6 1.9 5.4 5 0 0 5 5 5 5 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 EMC87481.1 - 5e-08 33.4 9.2 1.6 9.3 0.1 5.4 5 0 0 5 5 5 5 Hepsin, SRCR domain REGB_T4 PF10715.9 EMC87481.1 - 0.18 12.0 0.6 33 4.7 0.0 2.6 3 0 0 3 3 3 0 T4-page Endoribonuclease RegB VWD PF00094.25 EMC87482.1 - 1.2e-34 119.9 2.6 1.2e-34 119.9 2.6 2.6 2 0 0 2 2 2 1 von Willebrand factor type D domain C8 PF08742.11 EMC87482.1 - 1.5e-14 54.1 1.6 1.5e-14 54.1 1.6 5.5 5 1 1 6 6 6 1 C8 domain Cys_knot PF00007.22 EMC87482.1 - 2.3e-08 34.3 24.9 2.3e-08 34.3 24.9 6.4 3 1 4 7 7 7 1 Cystine-knot domain VWC PF00093.18 EMC87482.1 - 0.00058 20.1 34.5 0.0013 19.0 15.0 8.4 6 2 1 7 7 7 4 von Willebrand factor type C domain TIL PF01826.17 EMC87482.1 - 0.00069 19.8 11.8 0.00069 19.8 11.8 9.3 5 2 4 9 9 9 1 Trypsin Inhibitor like cysteine rich domain VWD PF00094.25 EMC87483.1 - 6.8e-111 367.6 29.1 2.8e-30 105.7 4.8 4.8 4 0 0 4 4 4 4 von Willebrand factor type D domain C8 PF08742.11 EMC87483.1 - 1.1e-48 163.5 55.6 5.7e-18 65.1 13.4 10.7 12 2 2 14 14 14 4 C8 domain TIL PF01826.17 EMC87483.1 - 3.1e-19 68.9 67.3 8e-13 48.4 15.3 17.9 14 4 4 19 19 19 5 Trypsin Inhibitor like cysteine rich domain VWC PF00093.18 EMC87483.1 - 2.3e-08 34.2 45.5 1.9e-05 24.9 6.8 17.8 15 6 3 18 18 18 7 von Willebrand factor type C domain MFS_1 PF07690.16 EMC87484.1 - 1.1e-15 57.5 16.8 1.4e-09 37.4 3.4 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily MFS_2 PF13347.6 EMC87484.1 - 8.7e-07 27.8 0.9 8.7e-07 27.8 0.9 2.4 2 0 0 2 2 2 1 MFS/sugar transport protein OATP PF03137.20 EMC87484.1 - 0.027 12.8 4.1 0.75 8.0 0.2 2.8 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Caps_synth_CapC PF14102.6 EMC87484.1 - 2.6 8.5 12.1 0.033 14.6 2.3 2.7 2 1 0 2 2 2 0 Capsule biosynthesis CapC uDENN PF03456.18 EMC87485.1 - 1.7e-06 28.7 0.0 4.2e-06 27.4 0.0 1.9 1 1 0 1 1 1 1 uDENN domain DENN PF02141.21 EMC87485.1 - 0.039 13.9 0.1 0.068 13.1 0.1 1.4 1 0 0 1 1 1 0 DENN (AEX-3) domain PKD_channel PF08016.12 EMC87486.1 - 1.2e-06 27.5 11.7 1.4e-06 27.3 11.7 1.0 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.31 EMC87486.1 - 0.00063 19.1 11.3 0.00074 18.8 11.3 1.1 1 0 0 1 1 1 1 Ion transport protein Annexin_like PF18411.1 EMC87487.1 - 0.006 16.8 0.1 0.0072 16.6 0.1 1.1 1 0 0 1 1 1 1 Annexin-like domain CARMIL_C PF16000.5 EMC87488.1 - 4.5e-101 338.5 11.3 4.5e-101 338.5 11.3 1.9 2 0 0 2 2 2 1 CARMIL C-terminus Carm_PH PF17888.1 EMC87488.1 - 1.2e-22 80.1 0.0 3.1e-22 78.7 0.0 1.8 1 0 0 1 1 1 1 Carmil pleckstrin homology domain LRR_6 PF13516.6 EMC87488.1 - 4.2e-11 42.0 27.4 0.0019 18.1 0.1 8.9 10 0 0 10 10 10 5 Leucine Rich repeat LRR_4 PF12799.7 EMC87488.1 - 0.0044 17.4 27.7 2.6 8.6 1.3 6.8 3 2 4 8 8 8 5 Leucine Rich repeats (2 copies) IL34 PF15036.6 EMC87488.1 - 0.038 14.0 0.3 0.13 12.3 0.3 1.9 1 0 0 1 1 1 0 Interleukin 34 LRR_1 PF00560.33 EMC87488.1 - 0.14 12.8 16.3 70 4.6 0.3 8.1 8 0 0 8 8 8 0 Leucine Rich Repeat Ribosomal_L34 PF00468.17 EMC87488.1 - 0.16 12.0 0.5 2.8 8.0 0.0 2.4 2 0 0 2 2 2 0 Ribosomal protein L34 PL48 PF15903.5 EMC87489.1 - 6.9e-173 574.5 2.5 3.8e-171 568.8 2.5 2.3 1 1 0 1 1 1 1 Filopodia upregulated, FAM65 HEAT_2 PF13646.6 EMC87489.1 - 6.1e-05 23.3 3.5 0.00017 21.9 0.2 2.8 2 1 1 3 3 3 1 HEAT repeats Arm PF00514.23 EMC87489.1 - 0.016 15.3 4.6 1.8 8.7 0.1 3.2 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat SHE3 PF17078.5 EMC87489.1 - 0.068 12.9 4.2 0.25 11.0 4.1 2.1 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 GvpD PF07088.11 EMC87489.1 - 0.072 11.7 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 GvpD gas vesicle protein HR1 PF02185.16 EMC87489.1 - 0.2 11.8 0.1 0.2 11.8 0.1 2.8 3 0 0 3 3 3 0 Hr1 repeat Geminin PF07412.12 EMC87490.1 - 4.2e-80 268.2 15.1 4.6e-80 268.0 15.1 1.0 1 0 0 1 1 1 1 Geminin Cut12 PF11500.8 EMC87490.1 - 0.0028 17.6 10.2 0.0033 17.4 9.8 1.4 1 1 0 1 1 1 1 Spindle pole body formation-associated protein Phage_GPO PF05929.11 EMC87490.1 - 0.0076 15.9 4.4 0.011 15.4 4.4 1.2 1 0 0 1 1 1 1 Phage capsid scaffolding protein (GPO) serine peptidase Laminin_II PF06009.12 EMC87490.1 - 0.0095 16.0 2.9 0.0095 16.0 2.9 2.0 2 0 0 2 2 2 1 Laminin Domain II UPF0242 PF06785.11 EMC87490.1 - 0.015 15.4 11.2 0.023 14.8 10.8 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DivIC PF04977.15 EMC87490.1 - 0.015 15.1 1.4 0.015 15.1 1.4 2.0 2 0 0 2 2 2 0 Septum formation initiator PHD_like PF12910.7 EMC87490.1 - 0.022 14.8 0.7 0.053 13.5 0.1 1.7 1 1 1 2 2 2 0 Antitoxin of toxin-antitoxin, RelE / RelB, TA system FapA PF03961.13 EMC87490.1 - 0.04 12.5 5.0 0.048 12.3 5.0 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Fzo_mitofusin PF04799.13 EMC87490.1 - 0.047 13.2 3.4 0.082 12.5 3.3 1.5 1 1 0 1 1 1 0 fzo-like conserved region Csm1_N PF18504.1 EMC87490.1 - 0.051 13.9 3.7 0.051 13.9 3.7 2.8 1 1 1 2 2 2 0 Csm1 N-terminal domain Sigma70_ner PF04546.13 EMC87490.1 - 0.065 13.1 7.4 0.088 12.7 7.4 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region CCDC-167 PF15188.6 EMC87490.1 - 1.3 9.4 12.5 0.9 9.9 9.5 2.2 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 DUF5094 PF17015.5 EMC87490.1 - 1.9 8.6 11.3 5.6 7.0 11.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF5094) DUF641 PF04859.12 EMC87490.1 - 3.5 8.0 10.9 19 5.6 9.9 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DUF4566 PF15130.6 EMC87491.1 - 7.4e-139 460.6 2.5 8.3e-139 460.4 2.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4566) 4HBT PF03061.22 EMC87492.1 - 8.1e-14 51.7 0.0 1.2e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 EMC87492.1 - 0.0001 22.6 0.1 0.00014 22.3 0.1 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily DUF4442 PF14539.6 EMC87492.1 - 0.0021 18.2 0.2 0.0061 16.7 0.1 1.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4442) Hexapep_loop PF18776.1 EMC87492.1 - 0.055 13.1 0.1 0.092 12.4 0.1 1.4 1 0 0 1 1 1 0 Hexapeptide repeat including loop Exo_endo_phos PF03372.23 EMC87493.1 - 5.2e-08 32.7 0.0 7.7e-08 32.1 0.0 1.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family 7tm_1 PF00001.21 EMC87494.1 - 4.3e-56 190.2 16.1 5.2e-56 189.9 16.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 EMC87494.1 - 5.8e-06 25.8 14.5 0.00067 19.0 14.5 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.6 EMC87494.1 - 7.9e-05 22.5 14.7 0.00019 21.2 14.7 1.6 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srv PF10323.9 EMC87494.1 - 0.00021 20.8 12.3 0.00028 20.4 12.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srd PF10317.9 EMC87494.1 - 0.00029 20.1 21.3 0.028 13.6 21.3 2.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srd Chitin_synth_1 PF01644.17 EMC87494.1 - 0.068 13.1 0.0 0.098 12.6 0.0 1.3 1 0 0 1 1 1 0 Chitin synthase Bac_rhodopsin PF01036.18 EMC87494.1 - 0.51 9.9 12.9 0.082 12.5 6.1 2.3 2 1 0 2 2 2 0 Bacteriorhodopsin-like protein Myelin_MBP PF01669.17 EMC87495.1 - 6.1e-57 192.5 7.6 9.4e-57 191.9 7.6 1.3 1 0 0 1 1 1 1 Myelin basic protein zf-H2C2_2 PF13465.6 EMC87496.1 - 2.1e-130 419.9 234.5 1.6e-09 37.7 0.3 32.5 33 0 0 33 33 33 25 Zinc-finger double domain zf-C2H2 PF00096.26 EMC87496.1 - 3.7e-113 364.1 286.2 3.7e-06 27.1 1.2 31.0 31 0 0 31 31 31 30 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC87496.1 - 4.2e-86 276.1 268.5 0.00034 21.2 0.5 30.5 30 0 0 30 30 30 28 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC87496.1 - 9e-40 134.2 182.8 0.0012 19.1 4.5 29.1 30 1 1 31 31 31 17 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMC87496.1 - 6.6e-15 54.7 239.4 0.0041 17.1 0.3 29.0 29 1 0 29 29 28 18 C2H2-type zinc finger zf-met PF12874.7 EMC87496.1 - 0.00026 21.3 205.0 0.018 15.4 0.0 26.4 28 0 0 28 28 27 11 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 EMC87496.1 - 0.00052 20.3 134.4 0.019 15.3 6.5 15.1 6 6 9 15 15 15 8 C2H2-type zinc ribbon zf-C2H2_11 PF16622.5 EMC87496.1 - 0.0012 18.6 143.6 0.0064 16.2 0.4 21.1 23 0 0 23 23 22 10 zinc-finger C2H2-type zf-H2C2_5 PF13909.6 EMC87496.1 - 0.0032 17.2 16.0 0.0072 16.1 1.2 30.4 30 5 0 30 30 29 14 C2H2-type zinc-finger domain zf-Di19 PF05605.12 EMC87496.1 - 0.0036 17.6 4.3 0.0036 17.6 4.3 19.4 11 7 8 21 21 21 12 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_9 PF14369.6 EMC87496.1 - 0.0045 17.2 81.0 3.8 7.8 0.3 18.5 19 3 1 20 20 19 3 zinc-ribbon zf-C2HC_2 PF13913.6 EMC87496.1 - 0.031 14.2 0.4 0.031 14.2 0.4 18.6 20 0 0 20 20 20 0 zinc-finger of a C2HC-type zf-C2H2 PF00096.26 EMC87497.1 - 1.5e-25 88.2 88.4 0.00053 20.3 6.8 10.8 10 0 0 10 10 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC87497.1 - 2.8e-19 68.1 84.2 0.0048 17.6 0.7 10.8 10 0 0 10 10 10 9 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC87497.1 - 7.7e-09 35.6 2.2 7.7e-09 35.6 2.2 12.4 14 1 0 14 14 14 3 Zinc-finger double domain zf-H2C2_5 PF13909.6 EMC87497.1 - 2.6e-06 27.1 2.0 2.6e-06 27.1 2.0 8.1 8 0 0 8 8 8 4 C2H2-type zinc-finger domain zf-Di19 PF05605.12 EMC87497.1 - 0.00013 22.2 36.6 0.8 10.0 0.9 5.9 4 2 0 4 4 4 4 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.6 EMC87497.1 - 0.22 11.4 40.5 0.14 12.1 2.0 7.2 7 0 0 7 7 7 0 zinc-finger of a C2HC-type zf-C2H2_3rep PF18868.1 EMC87497.1 - 0.55 10.9 23.4 0.067 13.9 4.7 6.1 6 1 1 7 7 7 0 Zinc finger C2H2-type, 3 repeats ARS2 PF04959.13 EMC87497.1 - 1.3 9.4 9.1 1.6 9.0 0.8 3.1 1 1 1 2 2 2 0 Arsenite-resistance protein 2 zf-C2H2_2 PF12756.7 EMC87497.1 - 2.2 8.7 51.6 0.28 11.5 10.3 7.7 6 2 3 9 9 9 0 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 EMC87497.1 - 3.6 7.4 51.1 0.094 12.5 2.9 7.7 8 0 0 8 8 8 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 EMC87498.1 - 4.2e-11 43.1 25.7 0.0041 17.4 1.1 5.6 5 2 1 6 6 5 4 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EMC87498.1 - 1.3e-10 41.2 28.9 0.038 14.5 1.3 5.6 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC87498.1 - 1.1e-09 38.3 23.7 0.069 14.0 2.8 5.7 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC87498.1 - 4.7e-05 23.3 21.8 0.024 14.6 2.4 4.6 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2HE PF16278.5 EMC87498.1 - 0.00037 20.9 12.0 2.4 8.7 0.0 6.0 5 0 0 5 5 5 2 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.7 EMC87498.1 - 0.0032 17.8 9.3 0.023 15.1 1.9 2.9 2 0 0 2 2 2 1 Zinc-finger of C2H2 type DUF760 PF05542.11 EMC87498.1 - 0.028 14.8 0.4 0.46 10.9 0.0 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF760) Lar_restr_allev PF14354.6 EMC87498.1 - 0.04 14.3 1.5 16 6.0 0.0 4.5 6 0 0 6 6 6 0 Restriction alleviation protein Lar zf-C2H2_jaz PF12171.8 EMC87498.1 - 0.043 14.1 0.8 0.043 14.1 0.8 4.9 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 EMC87498.1 - 0.06 13.5 11.1 6.4 7.0 0.1 5.4 5 0 0 5 5 5 0 Zinc ribbon domain zf-C2HC_2 PF13913.6 EMC87498.1 - 0.072 13.0 1.8 0.075 13.0 0.2 1.9 2 0 0 2 2 2 0 zinc-finger of a C2HC-type PyrI_C PF02748.15 EMC87498.1 - 0.39 10.7 2.1 4.1 7.4 0.1 3.2 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_11 PF16622.5 EMC87498.1 - 1.1 9.1 15.8 0.13 12.0 2.4 3.9 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-C2H2_9 PF16293.5 EMC87498.1 - 3.7 7.5 8.6 4.5 7.2 0.2 4.2 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) PP2C_C PF07830.13 EMC87498.1 - 5.1 7.6 6.5 0.46 11.0 0.9 2.2 2 0 0 2 2 1 0 Protein serine/threonine phosphatase 2C, C-terminal domain ADH_zinc_N PF00107.26 EMC87499.1 - 9.2e-28 96.8 0.0 1.5e-27 96.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMC87499.1 - 1.5e-14 55.2 0.0 6.6e-14 53.1 0.0 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMC87499.1 - 4.5e-08 32.9 0.2 0.00015 21.7 0.0 3.3 2 1 1 3 3 3 2 Alcohol dehydrogenase GroES-like domain PHB_acc_N PF07879.11 EMC87500.1 - 0.42 10.7 2.5 2.5 8.2 0.1 3.4 3 1 1 4 4 4 0 PHB/PHA accumulation regulator DNA-binding domain Peptidase_M20 PF01546.28 EMC87501.1 - 3e-36 125.1 0.0 3.8e-36 124.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EMC87501.1 - 6.6e-16 58.2 0.0 1.4e-15 57.1 0.0 1.6 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EMC87501.1 - 0.067 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 PIP49_C PF12260.8 EMC87502.1 - 8.5e-60 201.6 0.9 1.4e-59 201.0 0.3 1.6 2 0 0 2 2 2 1 Protein-kinase domain of FAM69 PIP49_N PF14875.6 EMC87502.1 - 4.3e-11 42.9 0.4 4.3e-11 42.9 0.4 1.6 2 0 0 2 2 2 1 N-term cysteine-rich ER, FAM69 DUF4708 PF15813.5 EMC87503.1 - 2.9e-28 98.8 0.2 3.3e-28 98.6 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4708) GP57 PF17594.2 EMC87503.1 - 0.15 11.8 0.0 0.22 11.3 0.0 1.5 1 1 0 1 1 1 0 Phage Tail fiber assembly helper gene product 57 TIM21 PF08294.11 EMC87504.1 - 2.4e-48 163.7 0.3 2.9e-48 163.4 0.3 1.1 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.10 EMC87504.1 - 4.3e-07 29.7 0.0 2.1e-06 27.4 0.0 1.9 1 1 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 F-box-like PF12937.7 EMC87505.1 - 3.1e-10 39.8 0.0 6.7e-10 38.7 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMC87505.1 - 2.1e-09 37.0 0.1 4.8e-09 35.9 0.1 1.7 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EMC87505.1 - 0.0078 16.1 0.0 0.018 14.9 0.0 1.7 1 0 0 1 1 1 1 F-box CUB PF00431.20 EMC87506.1 - 1.2e-39 135.1 0.5 3.3e-26 91.8 0.0 2.7 3 0 0 3 3 3 2 CUB domain Ldl_recept_a PF00057.18 EMC87506.1 - 1.4e-07 31.6 2.4 1.4e-07 31.6 2.4 2.7 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A C1q PF00386.21 EMC87508.1 - 2.1e-28 99.0 0.3 2.5e-28 98.8 0.3 1.0 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 EMC87508.1 - 0.015 15.2 0.1 0.026 14.4 0.1 1.4 1 1 0 1 1 1 0 BclA C-terminal domain DUF2828 PF11443.8 EMC87509.1 - 0.91 7.5 29.8 1.2 7.1 29.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Mpp10 PF04006.12 EMC87509.1 - 0.93 7.9 49.6 1.1 7.7 49.6 1.0 1 0 0 1 1 1 0 Mpp10 protein Rtf2 PF04641.12 EMC87509.1 - 0.95 8.8 41.6 1.1 8.5 41.6 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger CobT PF06213.12 EMC87509.1 - 1.1 8.6 39.3 1.5 8.2 39.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CCSAP PF15748.5 EMC87509.1 - 2 8.5 38.1 2.2 8.4 38.1 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF4045 PF13254.6 EMC87509.1 - 2.1 7.9 34.9 2.2 7.8 34.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF2052 PF09747.9 EMC87509.1 - 2.1 8.4 41.4 3.3 7.8 41.4 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Presenilin PF01080.17 EMC87509.1 - 4.2 6.0 33.0 5 5.8 33.0 1.0 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 EMC87509.1 - 4.2 7.1 45.9 5.9 6.6 45.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 EMC87509.1 - 4.8 6.1 30.9 5.1 6.0 30.9 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF4569 PF15133.6 EMC87509.1 - 4.9 6.8 25.3 5.3 6.7 25.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) CDC45 PF02724.14 EMC87509.1 - 5.6 5.1 43.8 6.1 5.0 43.8 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF5427 PF10310.9 EMC87509.1 - 6.2 5.7 37.0 6.9 5.5 37.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF4228 PF14009.6 EMC87509.1 - 8 6.8 21.8 9.9 6.5 21.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) AAA_11 PF13086.6 EMC87509.1 - 8.8 6.0 31.5 9.9 5.9 31.5 1.1 1 0 0 1 1 1 0 AAA domain RTTN_N PF14726.6 EMC87510.1 - 3.2e-30 104.8 6.3 9.8e-30 103.2 0.0 5.1 5 1 1 6 6 6 1 Rotatin, an armadillo repeat protein, centriole functioning IRS PF02174.17 EMC87511.1 - 5e-30 103.3 0.0 9.2e-30 102.5 0.0 1.4 1 0 0 1 1 1 1 PTB domain (IRS-1 type) PH PF00169.29 EMC87511.1 - 2.3e-05 24.8 0.9 4.6e-05 23.9 0.9 1.5 1 0 0 1 1 1 1 PH domain CREPT PF16566.5 EMC87511.1 - 0.096 12.9 0.6 0.23 11.6 0.2 1.7 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour WD40_alt PF14077.6 EMC87513.1 - 0.0031 17.3 2.6 0.034 14.0 0.6 2.8 3 0 0 3 3 3 1 Alternative WD40 repeat motif Filament PF00038.21 EMC87513.1 - 0.03 13.9 5.0 0.045 13.3 5.0 1.2 1 0 0 1 1 1 0 Intermediate filament protein Imm70 PF15601.6 EMC87513.1 - 0.46 10.0 3.0 2.8 7.5 0.3 2.2 1 1 1 2 2 2 0 Immunity protein 70 Seryl_tRNA_N PF02403.22 EMC87513.1 - 0.56 10.5 7.1 0.25 11.6 2.1 2.5 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain APG6_N PF17675.1 EMC87513.1 - 2.8 8.5 10.0 13 6.3 10.0 1.9 1 1 1 2 2 2 0 Apg6 coiled-coil region Fungal_TACC PF12709.7 EMC87513.1 - 3.2 8.3 7.7 0.2 12.1 1.4 2.3 2 2 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins TPR_MLP1_2 PF07926.12 EMC87513.1 - 5.2 7.1 13.4 69 3.5 10.5 2.8 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Thioredoxin_6 PF13848.6 EMC87514.1 - 4.3e-28 98.5 0.2 9.4e-26 90.8 0.6 2.2 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin PF00085.20 EMC87514.1 - 6.2e-26 90.4 0.0 1.9e-24 85.6 0.0 2.8 3 0 0 3 3 3 1 Thioredoxin Thioredoxin_2 PF13098.6 EMC87514.1 - 0.00015 22.2 0.2 0.0021 18.5 0.1 2.8 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EMC87514.1 - 0.00067 19.9 0.2 2.4 8.5 0.0 3.9 3 1 1 4 4 4 1 Thioredoxin-like Thioredoxin_7 PF13899.6 EMC87514.1 - 0.061 13.5 0.2 0.31 11.2 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin-like Transglut_C PF00927.22 EMC87515.1 - 1.3e-29 102.5 0.0 2.6e-17 62.9 0.0 2.6 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_core PF01841.19 EMC87515.1 - 1.6e-11 44.6 0.1 3.4e-11 43.6 0.1 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily Snf7 PF03357.21 EMC87517.1 - 4.1e-51 173.0 20.9 4.7e-51 172.8 20.9 1.0 1 0 0 1 1 1 1 Snf7 NPV_P10 PF05531.12 EMC87517.1 - 0.00086 19.7 1.6 0.00086 19.7 1.6 2.8 1 1 2 3 3 3 1 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 EMC87517.1 - 0.03 14.6 2.7 0.031 14.5 0.7 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Prefoldin_2 PF01920.20 EMC87517.1 - 0.066 13.2 21.8 0.58 10.1 0.8 3.5 2 1 1 3 3 3 0 Prefoldin subunit Alpha-E PF04168.12 EMC87517.1 - 0.08 12.7 1.2 0.13 12.0 0.8 1.4 1 1 0 1 1 1 0 A predicted alpha-helical domain with a conserved ER motif. Hydantoinase_B PF02538.14 EMC87517.1 - 0.19 10.1 1.3 0.21 10.0 1.3 1.1 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase BCDHK_Adom3 PF10436.9 EMC87517.1 - 0.21 11.4 2.7 0.29 11.0 2.7 1.2 1 0 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase GvpK PF05121.12 EMC87517.1 - 1.2 9.2 11.7 1.2 9.2 2.6 3.1 2 1 0 3 3 3 0 Gas vesicle protein K DUF848 PF05852.11 EMC87517.1 - 1.6 8.8 9.6 0.77 9.9 6.7 1.9 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Endotoxin_N PF03945.14 EMC87517.1 - 1.6 8.3 6.4 3.3 7.4 6.4 1.5 1 1 0 1 1 1 0 delta endotoxin, N-terminal domain YlqD PF11068.8 EMC87517.1 - 3 8.2 18.2 10 6.5 5.3 2.1 1 1 1 2 2 2 0 YlqD protein CorA PF01544.18 EMC87517.1 - 3.2 7.0 15.1 5.2 6.3 9.5 2.8 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein Atg14 PF10186.9 EMC87517.1 - 9.4 5.2 11.0 12 4.8 11.0 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 BAG PF02179.16 EMC87518.1 - 1.7e-09 38.0 2.3 4.1e-09 36.8 2.3 1.7 1 1 0 1 1 1 1 BAG domain ubiquitin PF00240.23 EMC87518.1 - 2.9e-08 33.3 0.6 6e-08 32.3 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin family PHTB1_C PF14728.6 EMC87518.1 - 0.00043 19.5 0.8 0.00051 19.3 0.8 1.1 1 0 0 1 1 1 1 PTHB1 C-terminus Ubiquitin_5 PF18037.1 EMC87518.1 - 0.0064 16.8 0.9 0.017 15.5 0.0 2.1 2 1 0 2 2 2 1 Ubiquitin-like domain SesA PF17107.5 EMC87518.1 - 0.0078 16.4 2.8 0.014 15.6 2.8 1.4 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases TRPM_tetra PF16519.5 EMC87518.1 - 0.017 15.2 2.1 5.4 7.2 0.4 3.3 3 1 0 3 3 3 0 Tetramerisation domain of TRPM YPEB PF14620.6 EMC87518.1 - 0.02 14.3 1.0 0.03 13.7 1.0 1.3 1 0 0 1 1 1 0 YpeB sporulation DUF2247 PF10004.9 EMC87518.1 - 0.045 13.5 1.1 0.059 13.2 1.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2247) V_ATPase_I PF01496.19 EMC87518.1 - 0.065 11.2 0.5 0.069 11.1 0.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DASH_Duo1 PF08651.10 EMC87518.1 - 0.066 13.0 3.0 0.47 10.3 1.0 2.4 1 1 0 2 2 2 0 DASH complex subunit Duo1 PIN_8 PF18476.1 EMC87518.1 - 0.068 13.0 4.0 0.099 12.5 4.0 1.1 1 0 0 1 1 1 0 PIN like domain Sigma54_DBD PF04552.13 EMC87518.1 - 0.1 12.3 0.6 0.19 11.4 0.5 1.4 1 1 0 1 1 1 0 Sigma-54, DNA binding domain Spectrin PF00435.21 EMC87518.1 - 0.2 12.1 4.4 1.6 9.3 3.6 2.3 2 0 0 2 2 2 0 Spectrin repeat Baculo_PEP_C PF04513.12 EMC87518.1 - 0.23 11.5 1.6 0.58 10.2 1.6 1.8 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Sec34 PF04136.15 EMC87518.1 - 0.25 11.2 3.0 0.5 10.2 2.3 1.8 1 1 0 1 1 1 0 Sec34-like family DASH_Dad2 PF08654.10 EMC87518.1 - 0.27 11.7 3.3 0.34 11.3 0.9 2.1 1 1 1 2 2 2 0 DASH complex subunit Dad2 Prefoldin PF02996.17 EMC87518.1 - 0.47 10.4 7.3 0.93 9.4 1.6 2.5 1 1 1 2 2 2 0 Prefoldin subunit DUF1664 PF07889.12 EMC87518.1 - 0.61 10.1 3.3 1.9 8.5 2.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF4140 PF13600.6 EMC87518.1 - 0.62 10.5 4.3 1.7 9.1 1.0 2.8 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) GrpE PF01025.19 EMC87518.1 - 0.94 9.1 9.1 1.8 8.2 8.7 1.7 1 1 0 1 1 1 0 GrpE Seryl_tRNA_N PF02403.22 EMC87518.1 - 1.1 9.6 11.0 0.87 9.8 8.2 2.0 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain FlaC_arch PF05377.11 EMC87518.1 - 1.6 9.2 5.9 3.3 8.2 1.0 3.2 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) DUF2205 PF10224.9 EMC87518.1 - 3.8 7.6 8.0 4.9 7.2 0.5 3.2 4 0 0 4 4 3 0 Short coiled-coil protein 7tm_4 PF13853.6 EMC87520.1 - 1.6e-39 136.3 16.6 1.9e-39 136.1 16.6 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC87520.1 - 9.1e-30 103.8 15.5 1.2e-29 103.5 15.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC87520.1 - 0.07 12.5 15.7 0.14 11.5 15.0 1.8 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx DUF1980 PF09323.10 EMC87520.1 - 5.6 6.8 9.2 0.41 10.5 3.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) ECH_1 PF00378.20 EMC87521.1 - 1.6e-05 24.4 0.0 0.00023 20.6 0.0 2.0 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EMC87521.1 - 0.0001 22.0 0.1 0.0024 17.4 0.0 2.0 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase Metallophos PF00149.28 EMC87522.1 - 0.00029 21.4 0.0 0.014 15.9 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Mpv17_PMP22 PF04117.12 EMC87522.1 - 0.091 13.0 2.2 38 4.6 0.0 3.2 3 0 0 3 3 3 0 Mpv17 / PMP22 family Shal-type PF11601.8 EMC87522.1 - 0.56 9.8 3.7 69 3.1 0.0 3.2 3 0 0 3 3 3 0 Shal-type voltage-gated potassium channels, N-terminal TLV_coat PF00429.19 EMC87523.1 - 3.9e-48 164.5 0.9 4.2e-48 164.4 0.9 1.0 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) DUF2207 PF09972.9 EMC87523.1 - 0.025 13.4 0.0 0.025 13.4 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) S6OS1 PF15676.5 EMC87523.1 - 0.065 11.7 0.2 0.079 11.4 0.2 1.0 1 0 0 1 1 1 0 Six6 opposite strand transcript 1 family TLV_coat PF00429.19 EMC87524.1 - 4.2e-12 45.5 6.2 5.1e-12 45.3 6.2 1.0 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) Promethin PF16015.5 EMC87524.1 - 0.16 11.9 3.9 0.32 10.9 3.9 1.5 1 0 0 1 1 1 0 Promethin DUF2207 PF09972.9 EMC87524.1 - 0.23 10.2 0.1 0.26 10.0 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Ephrin PF00812.17 EMC87526.1 - 5.4e-33 113.9 0.2 6.8e-33 113.6 0.2 1.1 1 0 0 1 1 1 1 Ephrin LRR_6 PF13516.6 EMC87527.1 - 0.00041 20.2 0.0 0.036 14.1 0.0 2.3 2 0 0 2 2 2 2 Leucine Rich repeat LRR_6 PF13516.6 EMC87528.1 - 7.4e-10 38.1 6.9 1 9.6 0.0 8.5 9 1 1 10 10 10 2 Leucine Rich repeat F-box-like PF12937.7 EMC87528.1 - 5.7e-08 32.5 3.9 5.7e-08 32.5 3.9 1.9 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.7 EMC87528.1 - 3.7e-06 27.2 7.9 0.77 10.3 2.7 5.8 3 2 4 7 7 7 2 Leucine Rich repeats (2 copies) F-box PF00646.33 EMC87528.1 - 0.00044 20.0 5.4 0.00061 19.6 2.5 2.8 3 1 0 3 3 3 1 F-box domain Aldedh PF00171.22 EMC87528.1 - 0.074 11.6 0.0 0.21 10.1 0.0 1.6 2 0 0 2 2 2 0 Aldehyde dehydrogenase family DUF3885 PF13021.6 EMC87528.1 - 0.098 12.8 0.0 8.6 6.6 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3885) Pkinase_Tyr PF07714.17 EMC87529.1 - 1.9e-102 342.0 0.0 6.3e-102 340.3 0.0 1.9 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC87529.1 - 2.5e-50 171.3 0.0 9.1e-50 169.5 0.0 2.0 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 EMC87529.1 - 1.1e-21 76.7 0.0 4e-21 74.9 0.0 2.1 1 0 0 1 1 1 1 SH2 domain FCH PF00611.23 EMC87529.1 - 6.1e-12 45.7 2.8 6.1e-12 45.7 2.8 3.4 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain ABC1 PF03109.16 EMC87529.1 - 0.36 11.0 4.6 1.2 9.3 0.0 3.7 4 0 0 4 4 4 0 ABC1 family zf-RING_2 PF13639.6 EMC87530.1 - 2.9e-13 49.9 12.3 5.7e-13 49.0 12.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC87530.1 - 5.1e-08 32.6 10.8 1.1e-07 31.6 10.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMC87530.1 - 1.2e-06 28.6 11.8 3.4e-06 27.2 11.8 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EMC87530.1 - 1.4e-06 28.0 10.7 3e-06 27.0 10.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EMC87530.1 - 5e-06 26.2 10.3 1.1e-05 25.0 10.3 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 EMC87530.1 - 1.1e-05 25.3 9.7 2e-05 24.4 9.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EMC87530.1 - 1.8e-05 24.6 7.8 3.9e-05 23.6 7.8 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EMC87530.1 - 0.00042 20.1 8.3 0.00077 19.3 8.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EMC87530.1 - 0.00045 20.2 4.3 0.00095 19.2 4.3 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EMC87530.1 - 0.014 15.0 9.7 0.033 13.8 9.7 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type RINGv PF12906.7 EMC87530.1 - 0.024 14.7 12.0 0.059 13.5 12.0 1.7 1 0 0 1 1 1 0 RING-variant domain Prok-RING_4 PF14447.6 EMC87530.1 - 0.16 11.9 8.0 0.34 10.8 8.0 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 FANCL_C PF11793.8 EMC87530.1 - 0.38 11.0 12.4 2 8.6 12.4 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain Glyco_hydro_38N PF01074.22 EMC87531.1 - 1e-107 359.9 5.1 1.6e-107 359.2 5.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EMC87531.1 - 1.7e-41 142.7 0.0 3.7e-41 141.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EMC87531.1 - 1.9e-25 88.8 0.0 4e-25 87.8 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain WAC_Acf1_DNA_bd PF10537.9 EMC87531.1 - 0.009 16.5 0.5 0.028 14.9 0.5 1.8 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal Glyco_hydro_57 PF03065.15 EMC87531.1 - 0.012 14.9 0.1 0.021 14.0 0.1 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 Mito_carr PF00153.27 EMC87532.1 - 1e-18 67.0 0.1 1.4e-11 44.2 0.0 2.5 2 0 0 2 2 2 2 Mitochondrial carrier protein Utp21 PF04192.12 EMC87533.1 - 4.2e-65 219.5 0.1 6.5e-65 218.9 0.1 1.3 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 EMC87533.1 - 6.5e-21 74.3 10.2 1.6e-09 38.2 0.6 8.8 10 0 0 10 10 10 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC87533.1 - 1.1e-11 44.9 0.3 0.0026 18.0 0.0 6.8 4 3 4 8 8 8 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC87533.1 - 0.0008 19.3 0.1 1.5 8.6 0.0 3.8 3 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A Utp12 PF04003.12 EMC87533.1 - 0.0091 16.3 0.2 0.019 15.3 0.2 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family SGL PF08450.12 EMC87533.1 - 0.078 12.6 0.0 0.38 10.3 0.0 2.1 3 0 0 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region Ge1_WD40 PF16529.5 EMC87533.1 - 0.14 11.1 0.3 0.74 8.7 0.0 2.4 4 0 0 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Pkinase PF00069.25 EMC87534.1 - 4e-53 180.4 0.0 4.5e-53 180.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87534.1 - 4.7e-18 65.4 0.0 5.5e-18 65.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC87534.1 - 2.8e-06 26.9 0.0 3.3e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC87534.1 - 0.0041 16.5 0.0 0.0056 16.0 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMC87534.1 - 0.017 13.9 0.0 0.02 13.7 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EMC87534.1 - 0.031 14.2 0.0 0.043 13.7 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 EMC87534.1 - 0.16 11.6 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Alveol-reg_P311 PF11092.8 EMC87535.1 - 6.5e-31 106.3 0.0 7.2e-31 106.1 0.0 1.0 1 0 0 1 1 1 1 Neuronal protein 3.1 (p311) SRP19 PF01922.17 EMC87536.1 - 1.9e-29 102.4 0.0 2.4e-29 102.1 0.0 1.1 1 0 0 1 1 1 1 SRP19 protein NUDIX PF00293.28 EMC87537.1 - 0.14 12.2 0.0 0.33 11.0 0.0 1.6 2 0 0 2 2 2 0 NUDIX domain MCC-bdg_PDZ PF10506.9 EMC87538.1 - 1.5e-43 146.6 21.4 5.2e-28 96.8 7.3 7.5 6 2 1 7 7 7 2 PDZ domain of MCC-2 bdg protein for Usher syndrome Mod_r PF07200.13 EMC87538.1 - 0.00024 21.3 0.5 0.00024 21.3 0.5 6.3 4 1 2 6 6 6 1 Modifier of rudimentary (Mod(r)) protein Spc7 PF08317.11 EMC87538.1 - 0.001 18.0 4.1 0.001 18.0 4.1 5.8 4 1 2 6 6 6 3 Spc7 kinetochore protein APG6_N PF17675.1 EMC87538.1 - 0.013 16.0 4.7 0.013 16.0 4.7 7.6 3 1 3 6 6 6 0 Apg6 coiled-coil region SHE3 PF17078.5 EMC87538.1 - 0.015 15.0 1.7 0.015 15.0 1.7 6.3 4 2 0 5 5 5 0 SWI5-dependent HO expression protein 3 GAS PF13851.6 EMC87538.1 - 0.03 13.7 0.5 0.03 13.7 0.5 6.5 6 2 1 7 7 7 0 Growth-arrest specific micro-tubule binding ERM PF00769.19 EMC87538.1 - 1 9.1 88.6 0.015 15.1 12.4 5.0 3 2 0 4 4 4 0 Ezrin/radixin/moesin family DUF1359 PF07097.11 EMC87538.1 - 3.5 7.9 6.4 12 6.3 0.0 3.8 4 1 0 4 4 4 0 Protein of unknown function (DUF1359) CaMBD PF02888.16 EMC87539.1 - 7.7e-39 131.7 12.3 1.8e-38 130.5 10.7 2.2 2 0 0 2 2 2 1 Calmodulin binding domain SK_channel PF03530.14 EMC87539.1 - 3.6e-30 104.3 1.2 3.6e-30 104.3 1.2 2.5 2 0 0 2 2 2 1 Calcium-activated SK potassium channel Ion_trans_2 PF07885.16 EMC87539.1 - 8.9e-14 51.2 3.2 3.1e-13 49.5 3.2 2.0 1 0 0 1 1 1 1 Ion channel Med9 PF07544.13 EMC87539.1 - 0.0037 17.3 2.2 0.0039 17.2 0.6 1.8 1 1 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 IRK PF01007.20 EMC87539.1 - 0.18 11.6 5.0 0.17 11.7 2.4 2.2 2 1 0 2 2 2 0 Inward rectifier potassium channel transmembrane domain SlyX PF04102.12 EMC87539.1 - 0.42 11.3 0.1 0.42 11.3 0.1 2.5 2 0 0 2 2 2 0 SlyX Prefoldin_2 PF01920.20 EMC87539.1 - 1.5 8.8 11.8 14 5.7 6.6 3.3 1 1 2 3 3 3 0 Prefoldin subunit Prenyltrans PF00432.21 EMC87541.1 - 4.5e-42 141.5 7.9 4.7e-10 39.0 0.0 6.3 6 0 0 6 6 6 6 Prenyltransferase and squalene oxidase repeat Ank_2 PF12796.7 EMC87542.1 - 8.8e-55 183.2 18.8 2.8e-19 69.5 0.9 5.6 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC87542.1 - 2e-39 133.5 4.8 7.4e-11 42.4 0.1 6.9 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC87542.1 - 2e-38 126.0 10.2 1.2e-05 25.3 0.1 10.4 9 1 0 9 9 9 8 Ankyrin repeat Ank PF00023.30 EMC87542.1 - 5.1e-36 121.6 16.7 1.6e-05 25.1 0.0 9.0 8 1 1 9 9 9 8 Ankyrin repeat Ank_5 PF13857.6 EMC87542.1 - 4.7e-34 116.0 9.9 7.7e-09 35.7 0.6 7.0 4 1 3 7 7 7 5 Ankyrin repeats (many copies) TPR_12 PF13424.6 EMC87542.1 - 3.8e-05 23.9 0.0 0.12 12.7 0.0 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMC87542.1 - 0.03 14.4 0.8 0.47 10.7 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 EMC87542.1 - 0.04 13.8 0.2 0.45 10.4 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Cnd1 PF12717.7 EMC87542.1 - 0.17 11.9 1.0 1.5 8.8 0.0 2.8 3 1 1 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Guanylate_cyc PF00211.20 EMC87543.1 - 0.21 11.2 0.0 0.82 9.3 0.0 1.6 1 1 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain CDO_I PF05995.12 EMC87544.1 - 2.4e-53 179.9 0.0 2.8e-53 179.7 0.0 1.0 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 EMC87544.1 - 4.4e-05 23.0 0.3 0.00021 20.8 0.3 1.8 1 1 0 1 1 1 1 PCO_ADO Clat_adaptor_s PF01217.20 EMC87545.1 - 1.4e-41 141.7 2.9 1.7e-41 141.5 2.9 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Peptidase_M1 PF01433.20 EMC87546.1 - 1.5e-59 201.2 0.4 2.5e-59 200.5 0.4 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 EMC87546.1 - 4.7e-44 151.2 3.7 7.3e-44 150.6 3.7 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EMC87546.1 - 1.2e-23 84.2 0.4 2.8e-23 83.1 0.2 1.8 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain ARF7EP_C PF14949.6 EMC87547.1 - 4.4e-36 123.7 11.8 5.1e-36 123.5 11.8 1.0 1 0 0 1 1 1 1 ARF7 effector protein C-terminus COMM_domain PF07258.14 EMC87548.1 - 2.1e-11 43.8 0.7 2.1e-11 43.8 0.7 2.3 2 0 0 2 2 2 1 COMM domain Cytadhesin_P30 PF07271.11 EMC87548.1 - 0.17 11.4 0.2 0.22 11.0 0.2 1.2 1 0 0 1 1 1 0 Cytadhesin P30/P32 Sema PF01403.19 EMC87549.1 - 2.4e-133 445.0 0.0 3.9e-133 444.3 0.0 1.3 1 0 0 1 1 1 1 Sema domain PSI PF01437.25 EMC87549.1 - 9.1e-07 29.3 3.9 2.4e-06 28.0 3.9 1.7 1 0 0 1 1 1 1 Plexin repeat DUF3481 PF11980.8 EMC87549.1 - 0.059 13.1 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein DTW PF03942.15 EMC87551.1 - 3.9e-40 137.7 0.1 4.7e-40 137.4 0.1 1.1 1 0 0 1 1 1 1 DTW domain Rav1p_C PF12234.8 EMC87552.1 - 2.4e-84 284.0 0.0 1.5e-73 248.3 0.0 2.5 2 1 0 2 2 2 2 RAVE protein 1 C terminal WD40 PF00400.32 EMC87552.1 - 7.6e-14 51.9 31.0 0.0091 16.8 0.0 12.5 15 0 0 15 15 15 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC87552.1 - 0.00013 22.2 0.0 8.6 6.7 0.0 4.8 4 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain DUF758 PF05527.11 EMC87553.1 - 2e-77 259.3 8.6 2.2e-77 259.1 8.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF758) Pico_P2B PF01552.17 EMC87553.1 - 0.0024 18.0 0.6 0.0054 16.9 0.4 1.8 1 1 0 1 1 1 1 Picornavirus 2B protein DUF2408 PF10303.9 EMC87553.1 - 0.031 14.8 3.8 0.058 14.0 2.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) DUF459 PF04311.13 EMC87553.1 - 0.038 13.0 0.3 0.051 12.6 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF459) DUF4771 PF15995.5 EMC87553.1 - 0.038 14.3 1.0 0.048 13.9 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4771) HD_3 PF13023.6 EMC87553.1 - 0.04 13.8 1.0 0.075 13.0 1.0 1.5 2 0 0 2 2 2 0 HD domain Nup54 PF13874.6 EMC87553.1 - 0.048 13.8 3.2 0.043 13.9 1.7 1.7 2 1 0 2 2 2 0 Nucleoporin complex subunit 54 MaoC_dehydratas PF01575.19 EMC87554.1 - 1.2e-38 131.5 0.0 2.2e-38 130.6 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain adh_short PF00106.25 EMC87554.1 - 1.7e-31 109.2 0.0 3.2e-31 108.3 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC87554.1 - 8.1e-28 97.5 0.0 1.7e-27 96.5 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase SCP2 PF02036.17 EMC87554.1 - 1.3e-25 89.8 0.3 3.1e-25 88.6 0.3 1.7 1 0 0 1 1 1 1 SCP-2 sterol transfer family KR PF08659.10 EMC87554.1 - 2.3e-10 40.7 0.0 4.4e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 KR domain MaoC_dehydrat_N PF13452.6 EMC87554.1 - 2e-09 37.7 0.0 1.9e-07 31.3 0.0 2.3 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase Alkyl_sulf_C PF14864.6 EMC87554.1 - 1.2e-07 32.0 0.1 3.2e-07 30.6 0.1 1.7 2 0 0 2 2 2 1 Alkyl sulfatase C-terminal LolA_2 PF16584.5 EMC87554.1 - 2.5 8.0 4.4 10 5.9 0.2 2.7 2 0 0 2 2 2 0 Outer membrane lipoprotein carrier protein LolA DUF4589 PF15252.6 EMC87555.1 - 1.7e-79 267.3 5.2 1.9e-79 267.2 5.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4589) BUD22 PF09073.10 EMC87556.1 - 5.1e-11 42.6 7.2 5.1e-11 42.6 7.2 2.1 1 1 1 2 2 2 1 BUD22 Tom22 PF04281.13 EMC87556.1 - 0.41 10.4 3.4 0.86 9.4 3.4 1.6 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 Lysyl_oxidase PF01186.17 EMC87557.1 - 5.4e-79 264.6 3.7 5.9e-79 264.5 3.7 1.0 1 0 0 1 1 1 1 Lysyl oxidase CARDB PF07705.11 EMC87557.1 - 0.008 16.4 0.0 0.047 13.9 0.0 2.0 2 0 0 2 2 2 1 CARDB BsuPI PF12690.7 EMC87557.1 - 0.085 12.9 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Intracellular proteinase inhibitor Y_Y_Y PF07495.13 EMC87557.1 - 0.12 12.3 0.3 0.39 10.7 0.1 1.9 2 0 0 2 2 2 0 Y_Y_Y domain zf-C2HC_2 PF13913.6 EMC87558.1 - 9.1e-19 66.9 6.9 3.9e-10 39.4 0.6 2.7 3 0 0 3 3 3 2 zinc-finger of a C2HC-type zf-C2H2 PF00096.26 EMC87558.1 - 0.00061 20.1 3.0 0.18 12.3 0.0 2.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC87558.1 - 0.00077 20.1 3.7 1.6 9.7 0.3 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger c-SKI_SMAD_bind PF08782.10 EMC87558.1 - 0.0052 17.0 0.4 0.026 14.8 0.1 1.9 2 0 0 2 2 2 1 c-SKI Smad4 binding domain DUF2318 PF10080.9 EMC87558.1 - 0.012 15.7 1.1 2.1 8.5 0.2 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) Rad50_zn_hook PF04423.14 EMC87558.1 - 0.045 13.6 0.1 0.16 11.8 0.0 1.8 2 0 0 2 2 2 0 Rad50 zinc hook motif Vps36-NZF-N PF16988.5 EMC87558.1 - 0.074 12.5 1.8 0.41 10.1 0.0 2.2 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Zn_ribbon_recom PF13408.6 EMC87558.1 - 0.11 13.0 1.2 4.5 7.9 0.2 2.2 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf-C2HC_2 PF13913.6 EMC87559.1 - 1.7e-20 72.4 7.0 1.6e-11 43.8 0.8 2.6 3 0 0 3 3 3 2 zinc-finger of a C2HC-type zf-C2H2_4 PF13894.6 EMC87559.1 - 0.00085 20.0 5.4 0.15 13.0 0.4 3.2 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC87559.1 - 0.017 15.5 3.0 0.24 11.9 0.0 3.0 3 0 0 3 3 3 0 Zinc finger, C2H2 type DUF2318 PF10080.9 EMC87559.1 - 0.018 15.1 0.3 1 9.5 0.0 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) RNF220 PF15926.5 EMC87559.1 - 0.071 12.7 0.7 7.7 6.1 0.1 2.0 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase RNF220 Sgf11 PF08209.11 EMC87559.1 - 0.18 11.4 1.8 2.9 7.6 0.2 2.3 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) RINGv PF12906.7 EMC87559.1 - 5.2 7.3 7.0 21 5.3 1.6 2.6 2 1 0 2 2 2 0 RING-variant domain SNCAIP_SNCA_bd PF16700.5 EMC87560.1 - 8.6e-25 86.2 8.2 3e-24 84.5 8.2 2.0 1 0 0 1 1 1 1 Synphilin-1 alpha-Synuclein-binding domain Ank_2 PF12796.7 EMC87560.1 - 6.5e-24 84.3 5.0 6.2e-12 45.9 0.0 2.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC87560.1 - 9.9e-16 57.9 0.4 9.1e-07 29.3 0.0 3.6 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC87560.1 - 1.5e-13 50.7 0.2 7.1e-05 23.0 0.0 3.9 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EMC87560.1 - 9e-07 29.1 2.9 0.00036 20.8 0.2 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EMC87560.1 - 2.1e-05 24.6 0.6 0.52 11.0 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Vps5 PF09325.10 EMC87561.1 - 2.9e-84 282.3 18.8 2.9e-84 282.3 18.8 1.4 2 0 0 2 2 1 1 Vps5 C terminal like PX PF00787.24 EMC87561.1 - 2.7e-30 104.6 0.4 5.5e-29 100.4 0.1 2.4 2 0 0 2 2 2 1 PX domain Sorting_nexin PF03700.13 EMC87561.1 - 1.1e-16 61.6 2.3 3e-16 60.1 2.3 1.8 1 0 0 1 1 1 1 Sorting nexin, N-terminal domain Spc7 PF08317.11 EMC87561.1 - 0.0017 17.3 16.5 0.046 12.6 3.5 2.4 2 0 0 2 2 2 2 Spc7 kinetochore protein BAR_3_WASP_bdg PF10456.9 EMC87561.1 - 0.035 13.5 7.6 1.1 8.7 7.6 2.5 1 1 0 1 1 1 0 WASP-binding domain of Sorting nexin protein DUF4618 PF15397.6 EMC87561.1 - 0.16 11.4 13.4 0.11 11.9 1.3 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4618) DUF241 PF03087.14 EMC87561.1 - 0.24 11.2 10.7 0.083 12.7 0.9 2.6 1 1 2 3 3 3 0 Arabidopsis protein of unknown function DUF3138 PF11336.8 EMC87561.1 - 0.26 9.8 4.8 0.42 9.2 4.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) BLOC1_2 PF10046.9 EMC87561.1 - 0.33 11.3 14.4 0.19 12.1 1.0 3.7 2 2 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3775 PF12616.8 EMC87561.1 - 0.51 10.4 2.9 0.59 10.2 0.0 2.6 3 0 0 3 3 1 0 Protein of unknown function (DUF3775) HMMR_N PF15905.5 EMC87561.1 - 0.6 9.5 17.5 0.064 12.7 0.8 2.4 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Csm2_III-A PF03750.13 EMC87561.1 - 1.6 9.6 9.0 1.1 10.1 1.8 3.1 2 1 1 3 3 3 0 Csm2 Type III-A DUF2203 PF09969.9 EMC87561.1 - 1.7 9.4 10.3 4.7 7.9 1.6 3.0 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) HR1 PF02185.16 EMC87561.1 - 2 8.6 13.4 0.89 9.7 0.6 3.5 3 0 0 3 3 3 0 Hr1 repeat Exonuc_VII_L PF02601.15 EMC87561.1 - 2.6 7.5 18.7 0.63 9.6 6.5 2.2 1 1 1 2 2 2 0 Exonuclease VII, large subunit GrpE PF01025.19 EMC87561.1 - 2.9 7.6 17.5 0.27 10.9 6.1 2.6 2 0 0 2 2 2 0 GrpE Allexi_40kDa PF05549.11 EMC87561.1 - 3.3 7.1 7.9 0.61 9.5 0.7 2.6 2 1 1 3 3 3 0 Allexivirus 40kDa protein Seryl_tRNA_N PF02403.22 EMC87561.1 - 3.4 8.0 15.3 9.1 6.6 3.3 2.6 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Tropomyosin PF00261.20 EMC87561.1 - 3.8 6.8 17.3 0.056 12.8 4.3 2.4 2 0 0 2 2 2 0 Tropomyosin DHR10 PF18595.1 EMC87561.1 - 3.9 7.6 20.3 1.6 8.8 4.4 3.3 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain Sec34 PF04136.15 EMC87561.1 - 5 7.0 12.9 7.3 6.5 4.5 3.1 2 1 0 2 2 2 0 Sec34-like family Phage_HK97_TLTM PF06120.11 EMC87561.1 - 6.4 5.9 13.1 6.8 5.8 2.2 2.2 2 0 0 2 2 2 0 Tail length tape measure protein FlaC_arch PF05377.11 EMC87561.1 - 6.5 7.2 6.7 52 4.3 0.2 3.4 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) PX PF00787.24 EMC87562.1 - 7.7e-14 51.7 2.8 1.1e-13 51.1 2.1 1.6 1 1 1 2 2 2 1 PX domain DUF99 PF01949.16 EMC87562.1 - 0.25 10.7 0.0 0.35 10.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF99 Pro_isomerase PF00160.21 EMC87563.1 - 5.3e-47 160.0 0.1 6.2e-47 159.8 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-C2H2 PF00096.26 EMC87564.1 - 9.6e-12 44.7 23.1 3e-05 24.2 0.1 4.5 5 0 0 5 5 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC87564.1 - 9.6e-10 38.5 18.0 0.00019 22.0 1.5 4.5 5 0 0 5 5 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC87564.1 - 1.3e-09 38.0 14.7 0.0024 18.2 0.2 4.6 4 0 0 4 4 4 3 Zinc-finger double domain SET PF00856.28 EMC87564.1 - 4.3e-07 30.5 0.1 1.4e-05 25.6 0.1 2.4 1 1 0 1 1 1 1 SET domain zf-C2H2_jaz PF12171.8 EMC87564.1 - 0.00096 19.4 0.3 0.06 13.7 0.0 3.0 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 EMC87564.1 - 0.04 14.4 4.6 3.9 8.0 0.0 3.3 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-BED PF02892.15 EMC87564.1 - 0.17 11.9 4.4 7.9 6.6 0.3 3.6 2 1 1 3 3 3 0 BED zinc finger DUF629 PF04780.12 EMC87564.1 - 0.61 8.5 10.9 2.1 6.8 2.7 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF629) zf-C2HC_2 PF13913.6 EMC87564.1 - 0.62 10.0 0.0 0.62 10.0 0.0 3.6 4 0 0 4 4 4 0 zinc-finger of a C2HC-type zf-CHCC PF10276.9 EMC87564.1 - 0.86 9.7 4.4 0.96 9.6 0.6 2.5 2 0 0 2 2 2 0 Zinc-finger domain zf-C2H2_11 PF16622.5 EMC87564.1 - 1.2 9.0 11.0 0.89 9.4 0.1 3.8 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-LYAR PF08790.11 EMC87564.1 - 2.4 8.1 5.9 16 5.5 0.3 3.6 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger SR-25 PF10500.9 EMC87564.1 - 7.1 6.2 14.8 12 5.4 14.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein zf-C2H2_2 PF12756.7 EMC87564.1 - 9.5 6.6 8.0 35 4.8 0.0 3.5 2 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) SGT1 PF07093.11 EMC87566.1 - 2e-213 710.0 0.1 2.3e-213 709.9 0.1 1.0 1 0 0 1 1 1 1 SGT1 protein zf-RING_14 PF17978.1 EMC87566.1 - 0.073 13.5 0.1 0.17 12.3 0.1 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF3719 PF12516.8 EMC87567.1 - 7.7e-20 70.4 0.1 2.3e-19 68.8 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3719) DUF4303 PF14136.6 EMC87567.1 - 0.1 12.3 0.6 0.18 11.5 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4303) HMG_box PF00505.19 EMC87568.1 - 8.6e-29 99.8 16.9 1.3e-19 70.4 2.9 2.9 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC87568.1 - 1.4e-16 60.8 18.9 5.8e-10 39.6 3.5 3.1 3 1 0 3 3 3 2 HMG-box domain FAA_hydro_N_2 PF18288.1 EMC87568.1 - 0.0023 18.3 0.4 0.049 14.0 0.0 2.3 2 0 0 2 2 2 1 Fumarylacetoacetase N-terminal domain 2 YABBY PF04690.13 EMC87568.1 - 0.098 13.2 0.3 0.098 13.2 0.3 2.8 1 1 2 3 3 3 0 YABBY protein Protamine_like PF06382.11 EMC87568.1 - 0.11 12.7 12.5 1.2 9.3 1.0 3.1 1 1 2 3 3 3 0 Protamine and protamine like Endonuc_Holl PF10107.9 EMC87568.1 - 0.11 12.4 11.7 0.35 10.7 1.5 2.5 2 1 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase UQ_con PF00179.26 EMC87569.1 - 4.2e-52 175.5 0.0 4.7e-52 175.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EMC87569.1 - 0.0015 18.8 0.1 0.0024 18.1 0.0 1.4 2 0 0 2 2 2 1 RWD domain Prok-E2_B PF14461.6 EMC87569.1 - 0.007 16.1 0.0 0.0086 15.8 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EMC87569.1 - 0.093 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 UEV domain zf-CDGSH PF09360.10 EMC87571.1 - 8.3e-10 38.7 0.2 1.5e-09 37.9 0.2 1.5 1 0 0 1 1 1 1 Iron-binding zinc finger CDGSH type MitoNEET_N PF10660.9 EMC87571.1 - 3.3e-08 33.4 0.4 4.4e-08 33.0 0.4 1.2 1 0 0 1 1 1 1 Iron-containing outer mitochondrial membrane protein N-terminus DUF4307 PF14155.6 EMC87571.1 - 0.11 12.4 0.3 0.15 11.9 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4307) CHDNT PF08073.12 EMC87571.1 - 0.15 12.1 0.1 0.26 11.3 0.1 1.4 1 0 0 1 1 1 0 CHDNT (NUC034) domain IPK PF03770.16 EMC87572.1 - 1.7e-66 223.9 0.4 2.4e-66 223.4 0.4 1.2 1 0 0 1 1 1 1 Inositol polyphosphate kinase dUTPase PF00692.19 EMC87573.1 - 3.9e-13 49.2 0.0 5.1e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 dUTPase PT PF04886.12 EMC87575.1 - 0.011 15.3 0.1 0.53 9.9 0.0 3.0 2 1 0 2 2 2 0 PT repeat Yae1_N PF09811.9 EMC87576.1 - 4.8e-14 51.8 43.7 0.0036 17.0 9.8 5.6 2 2 1 3 3 3 3 Essential protein Yae1, N terminal Prokineticin PF06607.11 EMC87580.1 - 0.00028 21.1 5.8 0.00042 20.6 5.8 1.3 1 0 0 1 1 1 1 Prokineticin MIT_LIKE_ACTX PF17556.2 EMC87580.1 - 0.0021 18.6 6.0 0.0028 18.2 6.0 1.3 1 0 0 1 1 1 1 MIT-like atracotoxin family Dickkopf_N PF04706.12 EMC87580.1 - 0.0055 17.2 4.2 0.0055 17.2 4.2 2.2 1 1 1 2 2 2 1 Dickkopf N-terminal cysteine-rich region Pkinase PF00069.25 EMC87581.1 - 1.5e-71 240.9 0.0 1.9e-71 240.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87581.1 - 4.4e-36 124.5 0.0 5.9e-36 124.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase cNMP_binding PF00027.29 EMC87581.1 - 1.3e-20 73.3 0.0 2.8e-20 72.2 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Kinase-like PF14531.6 EMC87581.1 - 1.7e-05 24.3 0.0 2.7e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EMC87581.1 - 0.007 16.3 0.0 0.13 12.2 0.0 2.4 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pkinase_C PF00433.24 EMC87581.1 - 0.023 15.4 3.7 0.057 14.1 3.7 1.7 1 0 0 1 1 1 0 Protein kinase C terminal domain FTA2 PF13095.6 EMC87581.1 - 0.12 11.9 0.0 0.96 9.0 0.0 2.0 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 cNMP_binding PF00027.29 EMC87582.1 - 9.6e-06 25.6 0.0 2e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain RRM_1 PF00076.22 EMC87583.1 - 1.7e-40 136.7 1.6 5.9e-17 61.3 0.1 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DND1_DSRM PF14709.7 EMC87583.1 - 2.5e-25 88.5 0.1 5.4e-25 87.5 0.1 1.6 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 PHM7_cyt PF14703.6 EMC87583.1 - 4.7e-05 23.7 0.4 0.63 10.2 0.0 3.7 3 1 1 4 4 4 1 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 EMC87583.1 - 6.7e-05 22.9 0.1 0.86 9.8 0.0 3.2 3 1 0 3 3 3 2 RNA recognition motif RRM_5 PF13893.6 EMC87583.1 - 0.00034 20.2 0.1 0.48 10.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EMC87583.1 - 0.0016 18.4 0.1 1.1 9.3 0.0 2.6 2 0 0 2 2 2 2 Limkain b1 RRM_occluded PF16842.5 EMC87583.1 - 0.0081 16.0 0.1 7.2 6.5 0.0 2.9 3 0 0 3 3 3 2 Occluded RNA-recognition motif dsrm PF00035.26 EMC87583.1 - 0.014 16.1 0.6 0.68 10.7 0.1 2.9 2 1 0 2 2 2 0 Double-stranded RNA binding motif BRAP2 PF07576.12 EMC87583.1 - 0.016 15.4 0.1 0.14 12.4 0.0 2.3 3 0 0 3 3 3 0 BRCA1-associated protein 2 SET_assoc PF11767.8 EMC87583.1 - 0.032 13.9 0.1 7.7 6.2 0.1 2.4 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated HEPN_AbiU2 PF18734.1 EMC87583.1 - 0.11 12.0 0.1 0.19 11.2 0.1 1.3 1 0 0 1 1 1 0 AbiU2 Nup35_RRM_2 PF14605.6 EMC87583.1 - 0.35 10.9 1.2 37 4.4 0.1 2.8 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Ceramidase_alk PF04734.13 EMC87584.1 - 7.6e-229 760.5 0.0 9e-229 760.3 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 EMC87584.1 - 1.6e-50 171.3 0.1 2.3e-50 170.7 0.1 1.3 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal Pga1 PF10333.9 EMC87584.1 - 0.12 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 GPI-Mannosyltransferase II co-activator PAP2_C PF14360.6 EMC87585.1 - 1.8e-28 98.9 14.5 1.8e-28 98.9 14.5 2.4 3 0 0 3 3 3 1 PAP2 superfamily C-terminal SAM_3 PF18016.1 EMC87585.1 - 1.2e-06 28.3 0.0 3.9e-06 26.6 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PAP2 PF01569.21 EMC87585.1 - 2.2e-05 24.2 11.7 2.2e-05 24.2 11.7 1.8 2 1 0 2 2 2 1 PAP2 superfamily SAM_1 PF00536.30 EMC87585.1 - 0.00048 20.5 0.0 0.0011 19.4 0.0 1.6 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) PAP2_3 PF14378.6 EMC87585.1 - 0.004 16.9 12.8 0.004 16.9 12.8 2.3 1 1 1 2 2 2 1 PAP2 superfamily SAM_2 PF07647.17 EMC87585.1 - 0.0049 17.0 0.1 0.012 15.7 0.0 1.8 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 EMC87585.1 - 0.15 12.0 0.2 0.15 12.0 0.2 2.9 3 1 0 3 3 3 0 Sterile alpha motif (SAM)/Pointed domain His_Phos_2 PF00328.22 EMC87586.1 - 2.2e-21 76.7 0.1 2.6e-21 76.4 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF4708 PF15813.5 EMC87586.1 - 0.032 13.4 0.6 0.067 12.3 0.2 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4708) APS_kinase PF01583.20 EMC87587.1 - 4.8e-73 244.3 0.0 7.9e-73 243.6 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase ATP-sulfurylase PF01747.17 EMC87587.1 - 6.7e-68 228.3 0.0 9.3e-68 227.9 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 EMC87587.1 - 3.7e-45 153.4 0.0 6.7e-45 152.6 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain AAA_33 PF13671.6 EMC87587.1 - 0.00014 22.0 0.0 0.00027 21.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMC87587.1 - 0.00042 20.8 0.0 0.0035 17.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EMC87588.1 - 1.7e-36 125.6 0.0 5.1e-36 124.0 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMC87588.1 - 4.8e-12 45.5 0.1 1.1e-11 44.4 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 EMC87588.1 - 2e-05 24.4 0.0 7e-05 22.6 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EMC87588.1 - 3.6e-05 24.1 1.0 0.081 13.2 0.1 2.9 2 1 1 3 3 3 2 AAA domain TniB PF05621.11 EMC87588.1 - 5.1e-05 22.8 0.3 0.35 10.2 0.0 3.5 3 1 1 4 4 4 1 Bacterial TniB protein AAA_14 PF13173.6 EMC87588.1 - 0.00014 21.9 0.0 0.00032 20.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EMC87588.1 - 0.00015 21.8 0.1 0.0015 18.5 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EMC87588.1 - 0.00017 22.0 1.2 0.0022 18.4 0.0 2.6 2 1 0 3 3 3 1 AAA ATPase domain AAA_25 PF13481.6 EMC87588.1 - 0.00031 20.4 0.1 0.85 9.2 0.0 2.6 3 0 0 3 3 2 2 AAA domain Rad17 PF03215.15 EMC87588.1 - 0.00055 19.9 0.3 0.008 16.1 0.0 2.4 1 1 2 3 3 3 1 Rad17 P-loop domain Mg_chelatase PF01078.21 EMC87588.1 - 0.0037 16.7 0.1 0.038 13.4 0.1 2.3 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EMC87588.1 - 0.0044 17.5 0.1 0.034 14.7 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_7 PF12775.7 EMC87588.1 - 0.0093 15.5 0.1 0.061 12.8 0.0 2.3 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_33 PF13671.6 EMC87588.1 - 0.012 15.8 0.0 0.023 14.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_2 PF07724.14 EMC87588.1 - 0.016 15.3 0.0 0.062 13.4 0.0 2.0 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) Zeta_toxin PF06414.12 EMC87588.1 - 0.016 14.5 0.0 0.051 12.8 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin IstB_IS21 PF01695.17 EMC87588.1 - 0.018 14.8 0.0 0.058 13.1 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein TsaE PF02367.17 EMC87588.1 - 0.02 14.9 0.1 0.35 10.9 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 EMC87588.1 - 0.024 15.0 0.0 0.049 14.0 0.0 1.7 1 1 0 1 1 1 0 RNA helicase AAA_21 PF13304.6 EMC87588.1 - 0.03 14.1 0.3 0.14 11.9 0.1 1.9 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system TIP49 PF06068.13 EMC87588.1 - 0.032 13.5 0.0 0.077 12.2 0.0 1.7 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_24 PF13479.6 EMC87588.1 - 0.036 13.8 0.0 0.08 12.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain PhoH PF02562.16 EMC87588.1 - 0.048 13.1 0.0 0.92 8.9 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein SKI PF01202.22 EMC87588.1 - 0.052 13.7 0.3 0.14 12.3 0.0 1.8 2 0 0 2 2 1 0 Shikimate kinase GRAS PF03514.14 EMC87588.1 - 0.059 12.3 0.0 0.099 11.6 0.0 1.3 1 0 0 1 1 1 0 GRAS domain family AAA_28 PF13521.6 EMC87588.1 - 0.088 13.0 1.0 3 8.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.6 EMC87588.1 - 0.11 12.6 1.1 0.4 10.8 0.0 2.5 3 1 0 3 3 2 0 Sigma-54 interaction domain ABC_tran PF00005.27 EMC87588.1 - 0.2 12.2 0.4 1.5 9.4 0.0 2.5 3 1 0 3 3 3 0 ABC transporter ATPase PF06745.13 EMC87588.1 - 0.23 10.8 1.7 0.9 8.8 0.0 2.7 3 1 0 4 4 4 0 KaiC AAA_17 PF13207.6 EMC87588.1 - 0.43 11.0 0.0 0.43 11.0 0.0 2.6 3 1 0 3 3 2 0 AAA domain PTEN_C2 PF10409.9 EMC87589.1 - 2e-45 153.8 2.7 3.1e-45 153.3 2.7 1.3 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 EMC87589.1 - 3.2e-08 33.5 0.1 1.9e-07 30.9 0.0 2.0 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC87589.1 - 0.00012 21.7 0.0 0.00032 20.3 0.0 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EMC87589.1 - 0.0025 17.8 0.0 0.0037 17.3 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EMC87589.1 - 0.0028 17.8 0.0 0.0062 16.7 0.0 1.6 1 0 0 1 1 1 1 Inositol hexakisphosphate Abhydro_lipase PF04083.16 EMC87590.1 - 1.8e-19 69.1 0.1 3.3e-19 68.2 0.1 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 EMC87590.1 - 1.4e-18 67.5 0.4 7.1e-18 65.2 0.4 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMC87590.1 - 0.0022 17.3 0.0 0.06 12.6 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMC87591.1 - 9.2e-25 87.7 0.3 1.6e-24 86.9 0.3 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 EMC87591.1 - 3.7e-20 71.3 0.0 7.2e-20 70.3 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 EMC87591.1 - 1.1e-08 34.7 0.0 1.3e-06 27.9 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 LIDHydrolase PF10230.9 EMC87591.1 - 0.014 15.0 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase DUF2974 PF11187.8 EMC87591.1 - 0.026 14.1 0.0 0.042 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) VirJ PF06057.11 EMC87591.1 - 0.075 12.9 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) DUF900 PF05990.12 EMC87591.1 - 0.15 11.5 0.1 0.25 10.8 0.1 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Amino_oxidase PF01593.24 EMC87592.1 - 5.6e-65 220.4 0.0 6.5e-65 220.2 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase MMR_HSR1 PF01926.23 EMC87593.1 - 1.1e-12 48.1 0.0 1.5e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EMC87593.1 - 8.9e-06 25.3 0.0 0.0001 21.9 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EMC87593.1 - 0.0001 22.3 0.0 0.00031 20.7 0.0 1.7 1 1 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 EMC87593.1 - 0.0018 18.6 0.1 0.014 15.8 0.1 2.4 2 1 0 2 2 2 1 AAA ATPase domain AIG1 PF04548.16 EMC87593.1 - 0.0038 16.6 0.0 0.0053 16.1 0.0 1.2 1 0 0 1 1 1 1 AIG1 family Ras PF00071.22 EMC87593.1 - 0.012 15.2 0.0 0.15 11.6 0.0 2.1 2 0 0 2 2 2 0 Ras family Roc PF08477.13 EMC87593.1 - 0.015 15.5 0.0 0.043 14.0 0.0 1.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 EMC87593.1 - 0.015 15.4 0.8 1 9.4 0.2 2.2 1 1 1 2 2 2 0 Dynamin family ATP_bind_1 PF03029.17 EMC87593.1 - 0.025 14.3 0.1 13 5.5 0.0 2.9 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein TniB PF05621.11 EMC87593.1 - 0.064 12.7 0.0 0.092 12.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein GTP_EFTU PF00009.27 EMC87593.1 - 0.065 12.8 0.0 12 5.3 0.0 2.9 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 EMC87593.1 - 0.069 12.9 0.0 0.093 12.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EMC87593.1 - 0.07 13.4 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain IIGP PF05049.13 EMC87593.1 - 0.11 11.5 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) G-alpha PF00503.20 EMC87593.1 - 0.11 11.6 0.0 0.33 10.1 0.0 1.7 2 0 0 2 2 2 0 G-protein alpha subunit SRPRB PF09439.10 EMC87593.1 - 0.14 11.6 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit ECH_1 PF00378.20 EMC87594.1 - 5.1e-55 186.5 0.1 5.8e-55 186.3 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EMC87594.1 - 4.3e-25 88.9 0.4 6.7e-25 88.3 0.4 1.3 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase TA0956 PF11513.8 EMC87594.1 - 0.14 12.4 0.0 0.2 11.9 0.0 1.2 1 0 0 1 1 1 0 Thermoplasma acidophilum protein TA0956 IKBKB_SDD PF18397.1 EMC87595.1 - 5.5e-137 455.6 9.7 7.6e-137 455.1 9.7 1.2 1 0 0 1 1 1 1 IQBAL scaffold dimerization domain Pkinase PF00069.25 EMC87595.1 - 7.6e-49 166.4 0.0 1.6e-48 165.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87595.1 - 4.1e-33 114.8 0.0 9e-33 113.6 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase IKKbetaNEMObind PF12179.8 EMC87595.1 - 4.1e-15 55.5 3.9 4.1e-15 55.5 3.9 2.6 3 0 0 3 3 3 1 I-kappa-kinase-beta NEMO binding domain Pkinase_fungal PF17667.1 EMC87595.1 - 1.2e-05 24.3 0.0 2.1e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EMC87595.1 - 0.00034 20.0 0.0 0.00086 18.7 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TBK1_ULD PF18396.1 EMC87595.1 - 0.0013 18.6 0.0 0.0036 17.2 0.0 1.7 2 0 0 2 2 2 1 TANK binding kinase 1 ubiquitin-like domain APH PF01636.23 EMC87595.1 - 0.0078 16.2 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family PNMA PF14893.6 EMC87595.1 - 0.0088 15.5 0.5 0.022 14.2 0.1 1.6 1 1 0 1 1 1 1 PNMA DUF3887 PF13026.6 EMC87595.1 - 0.078 13.8 0.2 0.21 12.5 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3887) Pep_M12B_propep PF01562.19 EMC87596.1 - 2.6e-33 115.2 0.1 4.4e-33 114.5 0.1 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin PF01421.19 EMC87596.1 - 7.6e-22 78.2 4.1 2.2e-15 57.1 0.5 2.6 2 0 0 2 2 2 2 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 EMC87596.1 - 2.6e-20 72.9 5.6 2.6e-20 72.9 5.6 3.7 3 1 0 3 3 1 1 ADAM cysteine-rich Disintegrin PF00200.23 EMC87596.1 - 3.1e-19 69.5 32.6 3.1e-19 69.5 32.6 3.9 3 1 0 3 3 3 1 Disintegrin Reprolysin_5 PF13688.6 EMC87596.1 - 1e-07 32.3 0.1 4.2e-06 27.0 0.2 2.5 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 EMC87596.1 - 9.5e-07 28.9 0.0 2.3e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EMC87596.1 - 4.1e-06 26.6 0.1 1.1e-05 25.2 0.0 1.6 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.13 EMC87596.1 - 0.00051 20.4 11.0 0.00051 20.4 11.0 6.2 4 1 1 5 5 4 1 EGF-like domain Reprolysin_3 PF13582.6 EMC87596.1 - 0.00063 20.3 0.1 0.0013 19.3 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 EMC87596.1 - 0.056 13.3 0.0 0.085 12.7 0.0 1.3 1 0 0 1 1 1 0 Matrixin MRI PF15325.6 EMC87596.1 - 0.065 14.3 0.6 0.15 13.2 0.6 1.5 1 0 0 1 1 1 0 Modulator of retrovirus infection GCP_C_terminal PF04130.13 EMC87597.1 - 1.9e-88 296.9 14.3 1.9e-88 296.9 14.3 2.2 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EMC87597.1 - 1.1e-77 261.7 1.0 1.1e-77 261.7 1.0 2.6 2 1 0 2 2 2 1 Gamma tubulin complex component N-terminal zf-Tim10_DDP PF02953.15 EMC87597.1 - 0.097 12.3 5.6 0.033 13.8 2.3 1.9 2 0 0 2 2 2 0 Tim10/DDP family zinc finger Adaptin_binding PF10199.9 EMC87597.1 - 0.32 11.6 1.5 0.53 10.9 0.2 2.0 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 NUDIX PF00293.28 EMC87599.1 - 5.5e-15 55.6 0.0 1.1e-14 54.6 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 EMC87599.1 - 2.5e-10 40.9 0.0 4.5e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.11 EMC87599.1 - 8.3e-09 35.0 0.2 1.6e-08 34.0 0.2 1.5 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain DUF2830 PF11125.8 EMC87599.1 - 0.0078 16.2 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2830) zf_ZIC PF18366.1 EMC87599.1 - 0.045 13.9 0.2 0.13 12.4 0.2 1.8 1 0 0 1 1 1 0 Zic proteins zinc finger domain P4Ha_N PF08336.11 EMC87600.1 - 9.4e-41 139.0 0.1 9.4e-41 139.0 0.1 1.7 2 0 0 2 2 2 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 2OG-FeII_Oxy_3 PF13640.6 EMC87600.1 - 6.2e-16 59.1 0.0 1.3e-15 58.1 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 EMC87600.1 - 1.9e-08 34.7 0.0 3.6e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TPR_2 PF07719.17 EMC87600.1 - 0.00022 21.1 2.2 0.00059 19.8 0.2 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMC87600.1 - 0.001 19.1 1.1 0.0097 16.0 1.1 2.5 1 1 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat TPR_14 PF13428.6 EMC87600.1 - 0.0033 18.1 0.9 0.0091 16.7 0.2 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat YfiO PF13525.6 EMC87600.1 - 0.034 13.8 2.8 0.077 12.7 2.8 1.5 1 0 0 1 1 1 0 Outer membrane lipoprotein TPR_18 PF13512.6 EMC87600.1 - 0.058 13.5 1.2 0.15 12.2 1.2 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 EMC87600.1 - 0.14 12.9 0.6 0.49 11.1 0.3 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC87600.1 - 0.15 12.3 1.1 0.57 10.4 0.5 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 PLA2G12 PF06951.11 EMC87601.1 - 2.4e-90 301.3 7.3 2.8e-90 301.1 7.3 1.0 1 0 0 1 1 1 1 Group XII secretory phospholipase A2 precursor (PLA2G12) Zona_pellucida PF00100.23 EMC87602.1 - 3.1e-49 168.1 0.2 1.4e-48 165.9 0.1 1.9 2 0 0 2 2 2 1 Zona pellucida-like domain FXa_inhibition PF14670.6 EMC87602.1 - 3.2e-17 62.5 29.8 1.9e-10 40.8 10.9 4.6 6 0 0 6 6 6 2 Coagulation Factor Xa inhibitory site cEGF PF12662.7 EMC87602.1 - 6.7e-07 29.1 18.4 0.0029 17.5 0.6 4.2 3 0 0 3 3 3 3 Complement Clr-like EGF-like MCU PF04678.13 EMC87603.1 - 5.1e-54 183.0 4.2 3.4e-52 177.1 4.2 2.1 1 1 0 1 1 1 1 Mitochondrial calcium uniporter DUF2960 PF11173.8 EMC87603.1 - 0.043 14.3 0.0 0.13 12.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2960) dCache_1 PF02743.18 EMC87603.1 - 0.15 11.8 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Cache domain WD40 PF00400.32 EMC87604.1 - 8e-14 51.8 15.5 2.6e-05 24.9 0.1 7.1 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC87604.1 - 4e-06 27.0 0.1 2 8.8 0.0 4.8 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 EMC87604.1 - 0.00031 20.6 0.1 0.00065 19.5 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMC87604.1 - 0.0057 16.5 0.1 0.013 15.4 0.1 1.5 1 0 0 1 1 1 1 F-box domain p450 PF00067.22 EMC87605.1 - 9.5e-126 420.2 0.0 1.1e-125 420.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4750 PF15938.5 EMC87605.1 - 1.5 8.5 7.5 0.17 11.6 2.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4750) BAR PF03114.18 EMC87606.1 - 9.2e-51 172.8 2.5 1.8e-50 171.8 2.5 1.5 1 0 0 1 1 1 1 BAR domain RhoGAP PF00620.27 EMC87606.1 - 2.9e-46 157.1 0.0 1.8e-45 154.4 0.0 2.0 2 0 0 2 2 2 1 RhoGAP domain DUF773 PF05600.12 EMC87606.1 - 0.021 13.6 0.6 0.034 12.9 0.6 1.2 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 UCH PF00443.29 EMC87607.1 - 1e-10 41.6 0.0 1.3e-10 41.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Homeodomain PF00046.29 EMC87609.1 - 1.1e-22 79.6 7.8 1.1e-22 79.6 7.8 1.8 2 0 0 2 2 2 1 Homeodomain CPSF73-100_C PF11718.8 EMC87609.1 - 0.79 9.2 9.1 2.1 7.8 0.1 2.1 2 0 0 2 2 2 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term FA_hydroxylase PF04116.13 EMC87610.1 - 1.7e-28 99.6 10.7 4.4e-28 98.3 10.7 1.7 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily F-box PF00646.33 EMC87611.1 - 1.5e-08 34.3 2.8 1.7e-08 34.1 0.2 2.6 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 EMC87611.1 - 2.6e-08 33.6 1.4 2.6e-08 33.6 1.4 2.4 3 0 0 3 3 3 1 F-box-like DUF4116 PF13475.6 EMC87611.1 - 0.0081 15.9 0.3 0.029 14.1 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4116) F-box_5 PF18511.1 EMC87611.1 - 0.017 14.7 0.0 0.037 13.6 0.0 1.5 1 0 0 1 1 1 0 F-box CLN5 PF15014.6 EMC87612.1 - 2.1e-166 553.0 4.8 2.3e-166 552.9 4.8 1.0 1 0 0 1 1 1 1 Ceroid-lipofuscinosis neuronal protein 5 Lipase3_N PF03893.16 EMC87612.1 - 0.057 13.5 0.1 0.17 11.9 0.1 1.9 1 0 0 1 1 1 0 Lipase 3 N-terminal region DJ-1_PfpI PF01965.24 EMC87613.1 - 0.00051 19.9 0.1 0.0015 18.4 0.1 1.8 1 1 0 1 1 1 1 DJ-1/PfpI family GATase_5 PF13507.6 EMC87613.1 - 0.087 11.9 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain MmgE_PrpD PF03972.14 EMC87614.1 - 2.2e-124 415.4 0.0 2.7e-124 415.1 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family DUF4757 PF15949.5 EMC87617.1 - 3.7e-49 167.5 32.1 6.7e-40 137.4 23.7 7.5 5 1 1 6 6 6 2 Domain of unknown function (DUF4757) PDZ PF00595.24 EMC87617.1 - 5.1e-09 36.4 0.0 1.4e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC87617.1 - 1.2e-07 31.5 0.0 2.4e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 PDZ domain LIM PF00412.22 EMC87617.1 - 1.5e-06 28.3 8.6 3.3e-06 27.2 8.6 1.6 1 0 0 1 1 1 1 LIM domain PDZ_2 PF13180.6 EMC87617.1 - 3.8e-06 27.1 0.0 1.4e-05 25.3 0.0 1.9 1 0 0 1 1 1 1 PDZ domain Peptidase_C12 PF01088.21 EMC87618.1 - 1.3e-66 224.4 0.0 1.4e-66 224.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 COMM_domain PF07258.14 EMC87619.1 - 1.6e-17 63.4 0.0 2.5e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 COMM domain CDT1_C PF16679.5 EMC87619.1 - 0.024 15.1 0.0 0.082 13.4 0.0 1.9 1 1 1 2 2 2 0 DNA replication factor Cdt1 C-terminal domain DUF2829 PF11195.8 EMC87619.1 - 0.049 13.9 0.0 0.083 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2829) DUF3870 PF12986.7 EMC87619.1 - 0.1 12.8 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3870) OSK PF17182.4 EMC87620.1 - 3.9e-05 23.0 0.0 7.7e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 OSK domain Lipase_GDSL_2 PF13472.6 EMC87620.1 - 7.2e-05 23.3 0.0 0.00015 22.2 0.0 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EMC87620.1 - 0.051 13.5 0.0 0.18 11.8 0.0 1.8 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase NAPRTase_N PF17767.1 EMC87620.1 - 0.11 12.8 0.0 0.37 11.2 0.0 1.7 2 0 0 2 2 2 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain zf-C2H2 PF00096.26 EMC87621.1 - 5.4e-16 58.1 23.1 6e-06 26.4 2.9 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC87621.1 - 7.9e-11 41.9 9.5 1.5e-07 31.5 1.4 3.8 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC87621.1 - 1.9e-06 28.2 20.2 0.056 14.3 1.9 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC87621.1 - 0.08 13.2 3.5 7 7.1 0.1 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC87621.1 - 0.09 13.2 2.9 8.7 6.9 0.4 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_aberr PF17017.5 EMC87621.1 - 0.15 12.2 2.7 7 6.8 0.0 2.2 2 0 0 2 2 2 0 Aberrant zinc-finger FOXP-CC PF16159.5 EMC87621.1 - 0.89 10.2 5.0 5.9 7.6 1.1 2.6 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 EMC87621.1 - 1.7 8.7 9.4 1.1 9.3 0.9 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC87623.1 - 1e-16 60.4 20.9 5.9e-06 26.5 2.4 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC87623.1 - 8.3e-12 45.0 7.5 1.7e-07 31.3 1.1 4.0 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC87623.1 - 7.4e-09 35.7 20.3 0.0016 19.1 2.0 4.0 4 0 0 4 4 4 3 C2H2-type zinc finger FOXP-CC PF16159.5 EMC87623.1 - 0.00062 20.3 4.6 0.1 13.2 0.1 2.7 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-met PF12874.7 EMC87623.1 - 0.0043 17.4 5.7 0.059 13.8 0.6 2.9 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EMC87623.1 - 0.026 14.5 1.4 0.026 14.5 1.4 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 EMC87623.1 - 0.042 14.0 5.0 1.2 9.2 0.1 2.3 2 0 0 2 2 2 0 Aberrant zinc-finger zf-C2HC_2 PF13913.6 EMC87623.1 - 0.14 12.1 0.5 0.38 10.7 0.2 2.0 2 0 0 2 2 2 0 zinc-finger of a C2HC-type IBR PF01485.21 EMC87623.1 - 0.7 10.2 6.9 3.4 7.9 6.9 2.0 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain zf-C2H2_jaz PF12171.8 EMC87623.1 - 2.8 8.3 7.8 2.4 8.5 0.1 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf_C2H2_ZHX PF18387.1 EMC87623.1 - 9 6.0 6.7 2.3 7.9 0.7 2.9 2 1 2 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain Secretin_N PF03958.17 EMC87624.1 - 2.8 8.4 4.6 0.91 10.0 0.2 2.5 3 0 0 3 3 3 0 Bacterial type II/III secretion system short domain Pox_A_type_inc PF04508.12 EMC87624.1 - 3.3 7.7 8.7 0.81 9.6 0.1 4.8 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat RNB PF00773.19 EMC87625.1 - 3.8e-102 342.0 0.1 6.9e-102 341.1 0.1 1.4 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 EMC87625.1 - 3.6e-23 81.4 0.0 9.2e-23 80.1 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Rrp44_CSD1 PF17216.3 EMC87625.1 - 1.7e-14 53.8 0.0 3.2e-14 52.9 0.0 1.5 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 EMC87625.1 - 1.4e-12 47.3 0.2 3.7e-12 46.0 0.2 1.7 1 0 0 1 1 1 1 S1 domain CSD2 PF17876.1 EMC87625.1 - 7.3e-11 42.1 0.2 1.9e-08 34.4 0.0 3.2 3 0 0 3 3 3 1 Cold shock domain PIN_4 PF13638.6 EMC87625.1 - 7.6e-09 36.0 1.1 2.3e-08 34.4 1.1 1.8 1 0 0 1 1 1 1 PIN domain Vps8 PF12816.7 EMC87625.1 - 0.029 13.9 0.0 0.073 12.6 0.0 1.6 1 0 0 1 1 1 0 Golgi CORVET complex core vacuolar protein 8 BORA_N PF15280.6 EMC87626.1 - 1.4e-67 227.7 3.4 4.7e-67 226.0 3.4 1.9 1 1 0 1 1 1 1 Protein aurora borealis N-terminus MOZART1 PF12554.8 EMC87627.1 - 9e-24 83.0 0.4 1e-23 82.8 0.4 1.0 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated Rad50_zn_hook PF04423.14 EMC87627.1 - 0.041 13.7 0.0 0.055 13.3 0.0 1.2 1 0 0 1 1 1 0 Rad50 zinc hook motif CBP_BcsN PF17038.5 EMC87627.1 - 0.09 12.1 0.1 0.094 12.1 0.1 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsN Yae1_N PF09811.9 EMC87628.1 - 2.7e-12 46.2 42.8 0.25 11.1 2.6 4.6 2 1 0 2 2 2 1 Essential protein Yae1, N terminal Kelch_1 PF01344.25 EMC87629.1 - 4e-60 199.2 13.2 1.8e-16 59.5 0.0 5.3 5 0 0 5 5 5 5 Kelch motif BACK PF07707.15 EMC87629.1 - 6.2e-33 113.0 0.2 1.8e-32 111.5 0.2 1.8 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_6 PF13964.6 EMC87629.1 - 9.3e-33 111.4 6.4 1.5e-10 40.9 0.0 5.5 2 2 3 5 5 5 5 Kelch motif BTB PF00651.31 EMC87629.1 - 2e-28 98.8 1.1 3.4e-28 98.1 0.4 1.8 2 0 0 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 EMC87629.1 - 8.2e-21 73.1 10.8 9.4e-07 28.6 0.0 5.9 6 0 0 6 6 6 3 Kelch motif Kelch_4 PF13418.6 EMC87629.1 - 1.1e-16 60.6 7.0 5e-06 26.4 0.0 5.2 4 1 1 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.6 EMC87629.1 - 2.4e-09 37.3 3.8 0.019 15.3 0.0 4.4 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC87629.1 - 1.1e-05 25.3 3.6 0.19 11.8 0.0 4.8 5 0 0 5 5 5 1 Kelch motif Glu_cyclase_2 PF05096.12 EMC87629.1 - 0.15 11.4 0.0 14 5.0 0.0 2.3 1 1 2 3 3 3 0 Glutamine cyclotransferase bZIP_1 PF00170.21 EMC87630.1 - 0.00037 20.5 53.9 0.0034 17.5 11.3 5.6 2 2 4 6 6 6 4 bZIP transcription factor APG6_N PF17675.1 EMC87630.1 - 0.0022 18.5 70.6 0.096 13.2 24.6 3.2 1 1 2 3 3 3 3 Apg6 coiled-coil region ZapB PF06005.12 EMC87630.1 - 0.014 15.8 72.3 2.6 8.6 10.6 5.4 1 1 4 5 5 5 0 Cell division protein ZapB DivIC PF04977.15 EMC87630.1 - 0.017 14.9 56.1 0.085 12.6 7.9 5.0 1 1 4 5 5 5 0 Septum formation initiator KASH_CCD PF14662.6 EMC87630.1 - 0.05 13.4 59.2 1.3 8.8 8.7 2.8 1 1 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH SHE3 PF17078.5 EMC87630.1 - 0.76 9.4 40.6 1.1 8.9 40.6 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 DUF2968 PF11180.8 EMC87630.1 - 2.4 7.8 48.5 0.041 13.5 17.8 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF2968) YabA PF06156.13 EMC87630.1 - 2.7 8.7 44.2 10 6.8 9.3 4.0 1 1 2 3 3 3 0 Initiation control protein YabA DUF4140 PF13600.6 EMC87630.1 - 5.1 7.6 40.5 0.15 12.5 6.8 4.3 1 1 2 3 3 2 0 N-terminal domain of unknown function (DUF4140) bZIP_Maf PF03131.17 EMC87630.1 - 6.3 7.4 44.8 2.4 8.7 3.7 4.4 1 1 3 4 4 4 0 bZIP Maf transcription factor TMF_TATA_bd PF12325.8 EMC87630.1 - 8.2 6.7 50.1 10 6.4 20.7 3.4 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding RVT_1 PF00078.27 EMC87633.1 - 0.012 15.1 0.1 0.027 14.0 0.1 1.5 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) Cadherin PF00028.17 EMC87635.1 - 2e-90 297.4 0.0 1.2e-19 70.5 0.0 6.6 7 0 0 7 7 7 6 Cadherin domain Cadherin_2 PF08266.12 EMC87635.1 - 7.2e-11 41.8 0.0 0.11 12.4 0.0 5.5 6 0 0 6 6 6 3 Cadherin-like RET_CLD1 PF17756.1 EMC87635.1 - 2.2e-05 24.8 0.0 5 7.4 0.0 3.9 4 0 0 4 4 4 3 RET Cadherin like domain 1 DUF4958 PF16319.5 EMC87635.1 - 0.0042 15.2 0.0 0.079 10.9 0.0 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4958) Cadherin_4 PF17803.1 EMC87635.1 - 0.37 11.4 16.7 3.4 8.4 0.3 4.9 5 0 0 5 5 5 0 Bacterial cadherin-like domain RMI1_N PF08585.12 EMC87636.1 - 7.1e-30 104.4 2.3 4.9e-23 82.0 0.0 3.6 2 1 1 3 3 3 2 RecQ mediated genome instability protein SMN PF06003.12 EMC87636.1 - 2.4e-10 40.1 0.0 2.4e-10 40.1 0.0 2.7 2 1 0 2 2 2 1 Survival motor neuron protein (SMN) TUDOR PF00567.24 EMC87636.1 - 6.7e-10 39.1 0.0 1.5e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Tudor domain UBA PF00627.31 EMC87636.1 - 1.1e-08 34.8 0.2 2.3e-08 33.8 0.2 1.6 1 0 0 1 1 1 1 UBA/TS-N domain RhoGAP PF00620.27 EMC87637.1 - 8.5e-18 64.6 1.4 2.7e-15 56.5 0.7 2.4 2 0 0 2 2 2 2 RhoGAP domain Drf_GBD PF06371.13 EMC87638.1 - 2e-21 76.4 2.2 2.6e-21 76.0 2.2 1.1 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain Closter_coat PF01785.17 EMC87638.1 - 0.038 13.3 0.3 0.048 12.9 0.3 1.1 1 0 0 1 1 1 0 Closterovirus coat protein FH2 PF02181.23 EMC87639.1 - 2.3e-109 365.9 26.7 2.3e-109 365.9 26.7 4.0 5 1 0 5 5 5 2 Formin Homology 2 Domain Drf_FH3 PF06367.16 EMC87639.1 - 1.3e-57 194.6 3.2 1.3e-57 194.6 3.2 3.8 3 1 1 4 4 4 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 EMC87639.1 - 6.5e-24 84.5 0.2 6.5e-24 84.5 0.2 3.2 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain Drf_DAD PF06345.11 EMC87639.1 - 9.5e-08 31.6 2.1 2.4e-07 30.3 2.1 1.8 1 0 0 1 1 1 1 DRF Autoregulatory Domain TMF_TATA_bd PF12325.8 EMC87639.1 - 0.0053 17.0 1.8 0.0053 17.0 1.8 5.8 5 1 1 6 6 6 2 TATA element modulatory factor 1 TATA binding PMEI PF04043.15 EMC87639.1 - 0.072 13.4 0.1 0.21 11.9 0.1 1.8 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor IL11 PF07400.11 EMC87639.1 - 0.74 9.4 9.0 1.4 8.6 3.1 3.8 2 1 2 4 4 4 0 Interleukin 11 DUF3361 PF11841.8 EMC87639.1 - 4.8 7.1 12.0 2.2 8.2 0.1 3.8 3 2 2 5 5 5 0 Domain of unknown function (DUF3361) Cadherin PF00028.17 EMC87640.1 - 5.2e-92 302.5 0.0 1.3e-17 64.0 0.0 6.5 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.12 EMC87640.1 - 7.4e-17 61.0 0.1 1.3e-09 37.8 0.0 4.9 5 0 0 5 5 5 2 Cadherin-like Cadherin_4 PF17803.1 EMC87640.1 - 1.9e-05 25.2 6.4 0.17 12.5 0.0 4.9 4 0 0 4 4 4 2 Bacterial cadherin-like domain Cadherin_C_2 PF16492.5 EMC87640.1 - 4.5e-05 24.1 0.0 0.00018 22.2 0.0 2.1 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal BRICHOS PF04089.14 EMC87642.1 - 3.8e-21 75.1 0.0 8.1e-21 74.1 0.0 1.5 1 0 0 1 1 1 1 BRICHOS domain GAPT PF11770.8 EMC87642.1 - 0.068 13.0 0.9 0.66 9.8 0.1 2.1 2 0 0 2 2 2 0 GRB2-binding adapter (GAPT) SGS PF05002.15 EMC87643.1 - 1e-33 115.2 2.4 1e-33 115.2 2.4 2.1 2 0 0 2 2 2 1 SGS domain CS PF04969.16 EMC87643.1 - 9.5e-18 65.0 3.2 1e-17 64.9 2.0 1.7 2 0 0 2 2 1 1 CS domain TPR_1 PF00515.28 EMC87643.1 - 9.2e-10 37.9 8.5 7.6e-06 25.5 3.6 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMC87643.1 - 2e-09 36.8 8.3 1.1e-05 25.2 2.7 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 EMC87643.1 - 1.6e-07 31.2 2.7 0.0014 18.9 0.5 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMC87643.1 - 9.7e-06 25.4 3.8 0.00048 20.1 1.6 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMC87643.1 - 2.4e-05 23.9 5.8 0.017 14.8 0.3 3.1 1 1 2 3 3 3 2 TPR repeat TPR_14 PF13428.6 EMC87643.1 - 0.0012 19.4 1.2 0.068 14.0 0.5 2.8 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMC87643.1 - 0.014 15.7 2.7 1.1 9.6 0.6 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_20 PF14561.6 EMC87643.1 - 0.018 15.4 2.4 0.088 13.1 0.8 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC87643.1 - 0.02 15.1 3.3 0.077 13.2 2.5 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EMC87643.1 - 0.024 15.3 1.5 0.26 12.0 0.6 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 EMC87643.1 - 0.044 13.9 0.1 0.41 10.8 0.0 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF2018 PF09442.10 EMC87643.1 - 0.075 14.0 0.1 0.22 12.5 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF2018) TPR_19 PF14559.6 EMC87643.1 - 0.087 13.3 2.5 1 9.9 0.4 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMC87643.1 - 0.98 9.5 5.4 9.8 6.3 0.8 3.0 3 1 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Elf-1_N PF12310.8 EMC87644.1 - 1.8e-48 163.7 5.3 1.8e-48 163.7 5.3 2.1 2 0 0 2 2 2 1 Transcription factor protein N terminal Ets PF00178.22 EMC87644.1 - 2.2e-34 117.8 1.0 3.7e-34 117.0 1.0 1.4 1 0 0 1 1 1 1 Ets-domain WW PF00397.26 EMC87645.1 - 5.8e-20 71.1 17.8 8.7e-10 38.5 4.5 2.6 2 0 0 2 2 2 2 WW domain zf-U1 PF06220.12 EMC87645.1 - 3.4e-14 52.3 0.9 5.3e-14 51.7 0.9 1.3 1 0 0 1 1 1 1 U1 zinc finger Glyco_hyd_101C PF17451.2 EMC87645.1 - 0.0021 18.3 14.7 0.098 13.0 0.7 3.3 1 1 1 2 2 2 2 Glycosyl hydrolase 101 beta sandwich domain PQQ PF01011.21 EMC87645.1 - 0.061 13.3 0.2 2.8 8.0 0.0 2.5 2 0 0 2 2 2 0 PQQ enzyme repeat PCRF PF03462.18 EMC87646.1 - 4.3e-50 170.3 0.2 4.3e-50 170.3 0.2 2.1 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 EMC87646.1 - 3.5e-39 133.3 3.4 1.1e-38 131.8 3.4 1.9 1 0 0 1 1 1 1 RF-1 domain HisKA PF00512.25 EMC87646.1 - 0.047 13.7 5.6 2.9 8.0 0.1 3.4 3 0 0 3 3 3 0 His Kinase A (phospho-acceptor) domain DUF4635 PF15466.6 EMC87646.1 - 1.7 8.2 9.8 18 4.8 3.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4635) CDI PF02234.19 EMC87646.1 - 2.1 8.6 4.4 4.3 7.6 0.0 3.4 3 0 0 3 3 3 0 Cyclin-dependent kinase inhibitor zf-C4pol PF14260.6 EMC87646.1 - 4.6 7.8 5.6 4.2 7.9 1.7 2.9 2 1 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta AAA_23 PF13476.6 EMC87646.1 - 9.1 6.7 14.4 13 6.2 1.0 2.4 2 0 0 2 2 2 0 AAA domain NARP1 PF12569.8 EMC87647.1 - 4.4e-222 738.6 21.5 4.4e-222 738.6 21.5 1.7 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 EMC87647.1 - 1.7e-13 49.5 28.6 3.7e-05 23.5 0.2 8.1 9 0 0 9 9 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 EMC87647.1 - 3.9e-13 49.0 3.8 0.091 13.6 0.0 9.2 9 1 1 10 10 9 1 Tetratricopeptide repeat TPR_8 PF13181.6 EMC87647.1 - 1.2e-11 43.8 27.1 0.00033 20.6 0.3 8.1 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 EMC87647.1 - 8.8e-11 41.3 8.3 8.3e-06 25.4 0.1 5.7 5 0 0 5 5 5 2 TPR repeat TPR_1 PF00515.28 EMC87647.1 - 5.1e-10 38.7 32.1 2e-05 24.2 0.6 8.6 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 EMC87647.1 - 3.2e-09 37.3 4.5 0.087 13.5 0.0 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMC87647.1 - 5.3e-09 36.5 10.5 0.041 14.4 0.3 5.8 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 EMC87647.1 - 2.2e-08 34.2 13.3 0.87 9.9 0.1 7.7 5 2 2 7 7 7 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC87647.1 - 3.3e-07 30.4 17.0 0.011 15.9 1.0 6.1 4 1 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 EMC87647.1 - 3e-05 23.4 1.9 3e-05 23.4 1.9 3.8 4 2 1 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 EMC87647.1 - 7.8e-05 22.4 11.0 0.071 13.2 0.1 7.0 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_9 PF13371.6 EMC87647.1 - 0.00033 20.7 4.3 0.53 10.5 0.2 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 EMC87647.1 - 0.0039 17.0 7.9 31 4.6 0.1 6.3 5 0 0 5 5 5 0 Tetratricopeptide repeat CENP-N PF05238.13 EMC87647.1 - 0.0076 15.6 1.7 0.012 14.9 1.7 1.3 1 0 0 1 1 1 1 Kinetochore protein CHL4 like DUF789 PF05623.12 EMC87647.1 - 0.042 13.5 2.3 0.087 12.5 2.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF789) TPR_4 PF07721.14 EMC87647.1 - 0.078 13.6 0.0 1.7e+02 3.3 0.1 4.5 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_21 PF09976.9 EMC87647.1 - 0.24 11.1 0.0 0.24 11.1 0.0 3.9 5 1 0 5 5 4 0 Tetratricopeptide repeat-like domain TPR_6 PF13174.6 EMC87647.1 - 0.77 10.5 12.9 32 5.4 0.1 6.1 7 1 0 7 7 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 EMC87647.1 - 1.6 9.3 18.5 1.7 9.2 0.0 7.2 9 0 0 9 9 7 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMC87647.1 - 2.7 8.1 23.2 9.5 6.4 0.2 6.7 7 0 0 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat MCD PF05292.11 EMC87647.1 - 8.6 5.8 9.7 1.5 8.3 0.1 3.0 3 0 0 3 3 3 0 Malonyl-CoA decarboxylase C-terminal domain DAGK_acc PF00609.19 EMC87648.1 - 1.1e-52 178.6 0.0 2.1e-52 177.7 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 EMC87648.1 - 1.8e-26 92.2 0.0 5.8e-26 90.6 0.0 1.9 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 EMC87648.1 - 2.8e-19 68.8 25.4 6.8e-10 38.7 5.2 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) SAM_2 PF07647.17 EMC87648.1 - 4.4e-17 61.9 1.0 9.2e-17 60.9 0.2 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PH PF00169.29 EMC87648.1 - 4.2e-16 59.3 0.7 1e-15 58.1 0.7 1.7 1 0 0 1 1 1 1 PH domain SAM_1 PF00536.30 EMC87648.1 - 5.8e-16 58.7 0.6 1.3e-15 57.6 0.6 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_8 PF15409.6 EMC87648.1 - 0.00019 21.7 0.3 0.00041 20.6 0.3 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain C1_2 PF03107.16 EMC87648.1 - 0.0012 19.1 16.0 0.0054 17.0 5.7 2.6 2 0 0 2 2 2 2 C1 domain PH_11 PF15413.6 EMC87648.1 - 0.0064 16.9 2.0 0.0064 16.9 2.0 2.8 2 1 0 2 2 2 1 Pleckstrin homology domain Mcp5_PH PF12814.7 EMC87648.1 - 0.039 14.1 0.1 0.089 12.9 0.1 1.6 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology SAM_4 PF18017.1 EMC87648.1 - 0.17 11.9 0.0 0.42 10.6 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) TERB2 PF15101.6 EMC87648.1 - 6.3 6.8 6.6 15 5.6 6.6 1.6 1 0 0 1 1 1 0 Telomere-associated protein TERB2 TNF PF00229.18 EMC87650.1 - 1.8e-32 111.9 0.7 2.8e-32 111.3 0.7 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family DnaJ PF00226.31 EMC87652.1 - 1.5e-06 28.3 0.0 2.5e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.13 EMC87652.1 - 0.0015 18.6 0.0 0.002 18.2 0.0 1.2 1 0 0 1 1 1 1 Pam16 DUF190 PF02641.15 EMC87653.1 - 0.035 14.4 0.5 0.11 12.9 0.2 2.0 2 0 0 2 2 2 0 Uncharacterized ACR, COG1993 Fer4_12 PF13353.6 EMC87653.1 - 0.39 11.0 4.7 2.8 8.2 0.3 3.0 2 2 0 2 2 2 0 4Fe-4S single cluster domain CENP-F_leu_zip PF10473.9 EMC87653.1 - 0.42 10.6 41.3 1.5 8.9 14.9 3.5 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MAD PF05557.13 EMC87653.1 - 0.59 8.4 38.5 0.027 12.9 23.5 2.0 1 1 1 2 2 2 0 Mitotic checkpoint protein DUF1664 PF07889.12 EMC87653.1 - 0.69 10.0 23.7 1.2 9.2 4.2 3.7 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) ENT PF03735.14 EMC87653.1 - 1.3 9.1 9.8 11 6.2 7.3 3.1 2 1 0 2 2 2 0 ENT domain Spc7 PF08317.11 EMC87653.1 - 1.5 7.7 38.4 1.6 7.5 17.5 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein zf-C4H2 PF10146.9 EMC87653.1 - 3.8 7.8 35.6 1.1 9.6 13.5 2.2 1 1 1 2 2 2 0 Zinc finger-containing protein LPP PF04728.13 EMC87653.1 - 5.1 7.6 7.8 12 6.4 0.0 4.4 5 1 0 5 5 5 0 Lipoprotein leucine-zipper PRKG1_interact PF15898.5 EMC87653.1 - 5.1 8.0 32.9 0.27 12.2 1.3 4.1 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain Fib_alpha PF08702.10 EMC87653.1 - 9.9 6.3 28.7 0.12 12.6 11.4 3.1 1 1 0 3 3 3 0 Fibrinogen alpha/beta chain family Cu-oxidase_4 PF02578.15 EMC87654.1 - 5.3e-56 189.8 0.0 6.9e-56 189.4 0.0 1.1 1 0 0 1 1 1 1 Multi-copper polyphenol oxidoreductase laccase TSC22 PF01166.18 EMC87655.1 - 2.3e-28 98.3 5.7 7.4e-28 96.6 5.7 1.9 1 0 0 1 1 1 1 TSC-22/dip/bun family YabA PF06156.13 EMC87655.1 - 0.00066 20.3 1.2 0.0017 18.9 1.2 1.7 1 0 0 1 1 1 1 Initiation control protein YabA K-box PF01486.17 EMC87655.1 - 0.025 14.7 1.5 0.056 13.6 1.5 1.5 1 0 0 1 1 1 0 K-box region bZIP_2 PF07716.15 EMC87655.1 - 1.9 8.7 5.1 3.8 7.7 5.1 1.4 1 0 0 1 1 1 0 Basic region leucine zipper ZapB PF06005.12 EMC87655.1 - 9.1 6.8 14.9 0.079 13.4 5.0 2.4 2 0 0 2 2 2 0 Cell division protein ZapB NUFIP1 PF10453.9 EMC87656.1 - 7.3e-19 67.4 6.6 7.3e-19 67.4 6.6 2.5 2 0 0 2 2 2 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-C2H2_jaz PF12171.8 EMC87656.1 - 4.6e-05 23.6 3.9 0.00011 22.4 3.9 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EMC87656.1 - 0.068 13.7 1.7 0.22 12.0 1.7 2.0 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC87656.1 - 0.28 12.2 3.6 2.4 9.2 0.3 2.7 1 1 1 2 2 2 0 C2H2-type zinc finger DUF3752 PF12572.8 EMC87657.1 - 4.4e-11 43.5 7.7 4.4e-11 43.5 7.7 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF3752) TFIIF_beta PF02270.15 EMC87658.1 - 8.5e-28 96.3 0.8 1.5e-27 95.5 0.2 1.7 2 0 0 2 2 2 1 TFIIF, beta subunit HTH domain TFIIF_beta_N PF17683.1 EMC87658.1 - 1.2e-19 71.3 0.6 6.8e-19 68.9 0.0 2.2 2 1 0 2 2 2 1 TFIIF, beta subunit N-terminus BTB_2 PF02214.22 EMC87659.1 - 2e-18 66.5 0.0 5e-18 65.2 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 EMC87659.1 - 0.021 14.9 0.0 0.043 13.9 0.0 1.5 1 0 0 1 1 1 0 BTB/POZ domain Mito_carr PF00153.27 EMC87660.1 - 9.8e-69 227.4 0.7 3.4e-24 84.6 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Sec34 PF04136.15 EMC87661.1 - 2e-55 186.7 6.4 2e-55 186.7 6.4 4.0 4 0 0 4 4 4 1 Sec34-like family Lant_dehydr_C PF14028.6 EMC87661.1 - 0.091 12.3 0.1 1.8 8.0 0.0 2.6 2 0 0 2 2 2 0 Lantibiotic biosynthesis dehydratase C-term PP2C_C PF07830.13 EMC87661.1 - 0.13 12.7 0.3 2.3 8.8 0.1 2.9 2 0 0 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain CLTH PF10607.9 EMC87661.1 - 0.18 11.7 7.3 0.027 14.3 1.0 2.8 3 0 0 3 3 3 0 CTLH/CRA C-terminal to LisH motif domain NPV_P10 PF05531.12 EMC87661.1 - 0.28 11.7 4.7 5.8 7.4 0.2 4.2 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein HisK_N PF09385.10 EMC87661.1 - 0.34 10.9 2.1 2.3 8.2 0.0 3.3 3 0 0 3 3 3 0 Histidine kinase N terminal DUF948 PF06103.11 EMC87661.1 - 0.4 11.0 5.3 30 4.9 0.1 5.0 4 1 1 5 5 5 0 Bacterial protein of unknown function (DUF948) Occludin_ELL PF07303.13 EMC87661.1 - 8.8 7.1 10.6 18 6.1 0.1 4.2 3 2 1 4 4 4 0 Occludin homology domain FAM194 PF14977.6 EMC87662.1 - 2.2e-55 187.1 0.0 2.6e-55 186.9 0.0 1.0 1 0 0 1 1 1 1 FAM194 protein MORN PF02493.20 EMC87662.1 - 0.0021 17.8 2.5 0.063 13.2 0.5 2.6 2 0 0 2 2 2 2 MORN repeat MORN_2 PF07661.13 EMC87662.1 - 0.04 14.1 0.0 1.5 9.3 0.0 2.7 2 0 0 2 2 2 0 MORN repeat variant DUF4140 PF13600.6 EMC87664.1 - 0.43 11.0 3.4 2.1 8.9 0.1 2.5 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) ZapB PF06005.12 EMC87664.1 - 3.2 8.3 11.5 1 9.9 1.0 3.4 4 0 0 4 4 4 0 Cell division protein ZapB Sina PF03145.16 EMC87665.1 - 1e-46 159.4 0.1 2.2e-46 158.3 0.0 1.5 1 1 1 2 2 2 1 Seven in absentia protein family Peptidase_M14 PF00246.24 EMC87666.1 - 2.3e-90 303.3 0.0 3.1e-90 302.9 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 EMC87666.1 - 8.7e-12 45.3 0.5 2.2e-11 44.0 0.5 1.7 1 0 0 1 1 1 1 Carboxypeptidase activation peptide DUF1642 PF07852.11 EMC87666.1 - 0.0082 16.7 0.6 0.052 14.1 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1642) LRR_8 PF13855.6 EMC87667.1 - 2.2e-24 85.0 8.9 2.3e-10 40.1 1.4 3.7 1 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EMC87667.1 - 8.4e-17 61.0 14.0 0.0014 19.0 0.1 5.6 2 1 2 5 5 5 5 Leucine Rich repeats (2 copies) CH PF00307.31 EMC87667.1 - 1.7e-11 44.3 0.0 4e-11 43.0 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain LRR_1 PF00560.33 EMC87667.1 - 2.4e-06 27.3 14.7 1.4 9.7 0.5 6.9 7 0 0 7 7 7 3 Leucine Rich Repeat LRR_6 PF13516.6 EMC87667.1 - 0.00084 19.2 10.3 1.5 9.1 0.5 5.3 5 0 0 5 5 5 2 Leucine Rich repeat CAMSAP_CH PF11971.8 EMC87667.1 - 0.0042 16.9 0.0 0.015 15.2 0.0 1.9 1 0 0 1 1 1 1 CAMSAP CH domain RVT_1 PF00078.27 EMC87668.1 - 0.0013 18.3 0.0 0.002 17.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) 7tm_1 PF00001.21 EMC87669.1 - 2.2e-68 230.4 12.8 3e-68 230.0 12.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC87669.1 - 4e-16 59.2 17.0 6.5e-16 58.5 17.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC87669.1 - 1.5e-07 31.4 8.2 1.5e-07 31.4 8.2 1.9 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC87669.1 - 3.1e-07 30.3 11.8 3.1e-07 30.3 11.8 2.4 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Bee_toxin PF17454.2 EMC87669.1 - 4 7.6 10.6 0.053 13.5 1.3 2.5 2 0 0 2 2 2 0 Honey bee toxin ATP-grasp_2 PF08442.10 EMC87670.1 - 4e-74 248.5 0.8 6.5e-74 247.9 0.2 1.6 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 EMC87670.1 - 2.8e-26 92.2 2.5 4.8e-26 91.4 2.5 1.4 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 EMC87670.1 - 1.2e-09 37.9 0.6 2.7e-09 36.8 0.1 1.8 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 EMC87670.1 - 0.049 13.4 0.3 0.15 11.9 0.3 1.7 1 1 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain nsp7 PF08716.10 EMC87670.1 - 0.19 12.4 2.0 5.8 7.6 0.3 2.7 2 1 0 2 2 2 0 nsp7 replicase BRICHOS PF04089.14 EMC87671.1 - 4.1e-20 71.8 0.0 7.6e-20 70.9 0.0 1.5 1 0 0 1 1 1 1 BRICHOS domain Antiterm PF03589.13 EMC87671.1 - 0.064 13.6 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Antitermination protein Rb_C PF08934.10 EMC87672.1 - 4.5e-80 266.8 3.2 4.5e-80 266.8 3.2 2.6 3 0 0 3 3 3 1 Rb C-terminal domain RB_A PF01858.17 EMC87672.1 - 5.3e-75 251.6 1.5 2.2e-74 249.6 0.2 2.4 2 0 0 2 2 2 1 Retinoblastoma-associated protein A domain RB_B PF01857.20 EMC87672.1 - 4.4e-31 107.7 4.7 1.4e-30 106.0 4.7 2.0 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain DUF3452 PF11934.8 EMC87672.1 - 6.1e-16 58.2 6.1 9e-14 51.2 2.8 3.5 3 0 0 3 3 3 2 Domain of unknown function (DUF3452) 7tm_1 PF00001.21 EMC87673.1 - 3e-54 184.1 30.6 4.2e-54 183.6 30.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC87673.1 - 3.2e-06 27.0 21.2 3.2e-06 27.0 21.2 2.2 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx MscS_TM PF12794.7 EMC87673.1 - 0.037 12.9 5.6 0.39 9.5 0.2 2.4 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 UCMA PF17085.5 EMC87673.1 - 0.16 11.9 0.8 1.4 9.0 0.5 2.3 1 1 1 2 2 2 0 Unique cartilage matrix associated protein RCC1 PF00415.18 EMC87674.1 - 8e-62 205.7 24.2 1.5e-15 57.5 1.2 6.2 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EMC87674.1 - 5.2e-32 109.0 25.3 2.9e-11 42.9 1.2 6.3 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EMC87674.1 - 3.2e-20 72.4 1.1 2.4e-17 63.2 0.1 2.3 1 1 1 2 2 2 2 BTB/POZ domain BACK PF07707.15 EMC87674.1 - 3.1e-06 27.2 2.2 0.00034 20.7 0.3 3.1 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF4213 PF13938.6 EMC87674.1 - 0.0098 16.1 3.1 2.9 8.2 0.0 3.1 2 1 0 2 2 2 2 Putative heavy-metal chelation Hira PF07569.11 EMC87674.1 - 0.043 13.5 2.9 4.6 6.9 0.0 4.1 5 0 0 5 5 5 0 TUP1-like enhancer of split Phage_int_SAM_5 PF13102.6 EMC87674.1 - 0.052 13.9 1.0 0.3 11.4 0.1 2.2 1 1 1 2 2 2 0 Phage integrase SAM-like domain Kelch_5 PF13854.6 EMC87674.1 - 3.1 7.9 8.6 45 4.2 0.2 4.4 4 0 0 4 4 4 0 Kelch motif Kelch_2 PF07646.15 EMC87674.1 - 6.6 6.9 8.7 15 5.7 0.2 4.7 5 0 0 5 5 5 0 Kelch motif 7tm_1 PF00001.21 EMC87675.1 - 6.5e-46 156.8 25.9 8.4e-46 156.4 25.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC87675.1 - 7.2e-06 25.8 20.4 7.2e-06 25.8 20.4 2.0 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 EMC87675.1 - 2.7e-05 23.7 16.6 2.7e-05 23.7 16.6 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv TAS2R PF05296.13 EMC87675.1 - 0.0026 16.9 25.4 0.007 15.5 25.4 1.6 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7TM_GPCR_Srw PF10324.9 EMC87675.1 - 0.02 14.2 26.8 0.75 9.0 26.8 2.1 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw fn3 PF00041.21 EMC87676.1 - 1.7e-90 297.5 0.0 1e-10 41.8 0.0 9.9 9 1 0 9 9 9 9 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 EMC87676.1 - 1.2e-19 70.6 10.7 0.043 14.4 0.4 9.6 8 2 1 9 9 9 7 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 EMC87676.1 - 5.6e-13 49.1 0.0 0.042 14.2 0.0 7.4 8 0 0 8 8 8 3 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.10 EMC87676.1 - 3.8e-06 27.2 2.5 0.1 12.9 0.1 5.7 6 0 0 6 6 6 1 Interferon-alpha/beta receptor, fibronectin type III IL6Ra-bind PF09240.10 EMC87676.1 - 0.16 12.4 2.9 14 6.2 0.2 2.8 2 0 0 2 2 2 0 Interleukin-6 receptor alpha chain, binding Orf78 PF06024.12 EMC87676.1 - 0.18 12.1 0.1 0.38 11.1 0.1 1.5 1 0 0 1 1 1 0 Orf78 (ac78) 7tm_1 PF00001.21 EMC87677.1 - 3e-27 95.6 3.2 3.3e-27 95.5 3.2 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC87677.1 - 9.2e-06 25.5 1.0 9.9e-06 25.4 1.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 EMC87677.1 - 1.4e-05 24.6 0.7 1.5e-05 24.6 0.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 EMC87677.1 - 0.0056 16.4 0.3 0.0056 16.4 0.3 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC87678.1 - 2e-15 56.8 1.7 2.4e-15 56.6 1.7 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 EMC87678.1 - 1.1e-09 38.0 0.2 1.3e-09 37.8 0.2 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.9 EMC87678.1 - 1.5e-06 27.8 1.4 1.9e-06 27.4 1.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx dCMP_cyt_deam_1 PF00383.23 EMC87679.1 - 9.8e-19 67.1 0.4 5.2e-09 35.9 0.0 2.7 2 1 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EMC87679.1 - 5.3e-12 45.7 0.8 4.4e-05 23.3 0.1 2.5 2 0 0 2 2 2 2 MafB19-like deaminase SNAD4 PF18750.1 EMC87679.1 - 0.0075 16.4 0.8 0.96 9.6 0.1 2.6 2 0 0 2 2 2 1 Secreted Novel AID/APOBEC-like Deaminase 4 NAD1 PF18778.1 EMC87679.1 - 0.032 14.3 0.8 2.4 8.2 0.1 2.3 2 0 0 2 2 2 0 Novel AID APOBEC clade 1 APOBEC3 PF18771.1 EMC87679.1 - 0.11 12.6 0.7 11 6.2 0.1 2.5 2 0 0 2 2 2 0 APOBEC3 AID PF18767.1 EMC87679.1 - 0.14 12.2 0.1 20 5.3 0.0 2.6 2 0 0 2 2 2 0 Activation induced deaminase Mo25 PF08569.11 EMC87680.1 - 6.5e-139 462.8 14.3 7.3e-139 462.7 14.3 1.0 1 0 0 1 1 1 1 Mo25-like HEAT_2 PF13646.6 EMC87680.1 - 0.047 14.1 0.0 0.14 12.5 0.0 1.8 1 0 0 1 1 1 0 HEAT repeats WcbI PF18588.1 EMC87680.1 - 0.11 12.1 0.1 2.4 7.7 0.0 2.5 2 1 1 3 3 3 0 Polysaccharide biosynthesis enzyme WcbI CC2-LZ PF16516.5 EMC87680.1 - 0.14 12.5 4.2 0.24 11.8 0.1 2.5 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator JmjN PF02375.17 EMC87680.1 - 0.77 9.8 2.6 3.5 7.7 0.2 3.0 3 0 0 3 3 3 0 jmjN domain zf-HC5HC2H PF13771.6 EMC87682.1 - 2.4e-14 53.3 7.3 2.8e-14 53.1 4.4 2.3 2 0 0 2 2 2 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EMC87682.1 - 3.3e-07 30.4 9.4 2.9e-06 27.4 8.8 2.4 1 1 0 1 1 1 1 PHD-zinc-finger like domain PHD PF00628.29 EMC87682.1 - 0.0057 16.5 11.9 0.29 11.0 9.1 2.7 2 1 0 2 2 2 2 PHD-finger DUF5314 PF17241.2 EMC87682.1 - 0.029 14.0 0.3 0.049 13.3 0.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5314) RCC1 PF00415.18 EMC87683.1 - 3.8e-62 206.7 25.6 7e-15 55.4 2.0 6.3 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EMC87683.1 - 2.5e-33 113.2 30.9 5.5e-10 38.8 2.3 6.5 6 1 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EMC87683.1 - 4.3e-22 78.4 0.6 3.8e-20 72.2 0.1 2.3 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 EMC87683.1 - 1e-06 28.8 1.0 0.0049 17.0 0.1 3.3 2 1 0 2 2 2 2 BTB And C-terminal Kelch PQQ_3 PF13570.6 EMC87683.1 - 0.31 11.6 4.8 19 5.9 0.0 4.3 5 0 0 5 5 5 0 PQQ-like domain SUKH-3 PF14433.6 EMC87683.1 - 0.5 10.8 1.7 7.6 7.0 0.0 3.2 4 1 0 4 4 4 0 SUKH-3 immunity protein Arf PF00025.21 EMC87684.1 - 5.2e-50 169.3 0.0 6.5e-50 169.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EMC87684.1 - 9.9e-12 44.7 0.0 7.4e-09 35.2 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 EMC87684.1 - 3.2e-11 43.5 0.0 4.2e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMC87684.1 - 6.6e-11 42.1 0.0 8.2e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EMC87684.1 - 1.1e-08 34.7 0.0 1.4e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EMC87684.1 - 6.9e-06 25.6 0.0 9.2e-06 25.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMC87684.1 - 0.00037 20.5 0.0 0.0005 20.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EMC87684.1 - 0.051 12.9 0.0 0.36 10.1 0.0 1.8 2 0 0 2 2 2 0 6-phosphofructo-2-kinase Arm PF00514.23 EMC87685.1 - 6.4e-88 286.4 17.1 1.2e-12 47.3 0.3 9.3 9 1 1 10 10 10 8 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 EMC87685.1 - 3.7e-24 84.0 2.4 9.6e-23 79.5 3.3 2.4 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_EZ PF13513.6 EMC87685.1 - 3.8e-24 84.7 1.3 1.4e-08 35.1 0.2 6.3 5 1 1 6 6 6 5 HEAT-like repeat HEAT_2 PF13646.6 EMC87685.1 - 7.6e-18 64.7 0.3 9.8e-07 29.1 0.0 6.3 3 2 4 8 8 8 3 HEAT repeats HEAT PF02985.22 EMC87685.1 - 1e-17 62.7 6.5 0.0032 17.6 0.0 6.8 7 0 0 7 7 6 3 HEAT repeat Adaptin_N PF01602.20 EMC87685.1 - 8.3e-09 34.5 0.1 1.5e-08 33.7 0.1 1.3 1 1 0 1 1 1 1 Adaptin N terminal region IBB PF01749.20 EMC87685.1 - 1.3e-07 32.0 0.8 3.2e-07 30.7 0.8 1.8 1 0 0 1 1 1 1 Importin beta binding domain Atx10homo_assoc PF09759.9 EMC87685.1 - 1.2e-05 25.3 1.9 1.8 8.7 0.0 4.8 3 1 3 6 6 6 2 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 EMC87685.1 - 1.2e-05 25.0 0.4 6.1 6.2 0.0 4.3 2 1 2 4 4 4 1 Armadillo-like V-ATPase_H_C PF11698.8 EMC87685.1 - 1.6e-05 25.0 0.6 1.3 9.2 0.1 4.3 4 1 1 5 5 5 1 V-ATPase subunit H Cnd1 PF12717.7 EMC87685.1 - 2.8e-05 24.2 0.4 0.29 11.2 0.0 3.4 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_N PF03224.14 EMC87685.1 - 7.1e-05 22.3 0.4 0.011 15.0 0.1 2.5 1 1 1 2 2 2 1 V-ATPase subunit H RasGEF_N_2 PF14663.6 EMC87685.1 - 0.019 15.4 0.1 14 6.2 0.0 3.8 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Mo25 PF08569.11 EMC87685.1 - 0.022 14.2 0.1 0.042 13.2 0.1 1.6 1 0 0 1 1 1 0 Mo25-like DRIM PF07539.12 EMC87685.1 - 0.1 10.9 0.1 5.6 5.1 0.0 2.4 2 0 0 2 2 2 0 Down-regulated in metastasis Proteasom_PSMB PF10508.9 EMC87685.1 - 0.13 10.7 0.5 0.83 8.1 0.1 2.4 2 2 0 2 2 2 0 Proteasome non-ATPase 26S subunit RPEL PF02755.15 EMC87685.1 - 0.14 11.9 0.2 23 4.9 0.1 2.7 2 0 0 2 2 2 0 RPEL repeat DUF1981 PF09324.10 EMC87685.1 - 0.17 11.8 0.5 2.5 8.0 0.2 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF1981) DCB PF16213.5 EMC87685.1 - 0.21 11.2 0.8 1.2 8.8 0.0 2.4 3 0 0 3 3 3 0 Dimerisation and cyclophilin-binding domain of Mon2 CTNNBL PF08216.11 EMC87685.1 - 0.21 11.8 2.0 33 4.7 0.0 3.8 4 2 1 5 5 4 0 Catenin-beta-like, Arm-motif containing nuclear SPRY PF00622.28 EMC87687.1 - 1.7e-16 60.4 0.0 2.5e-16 59.9 0.0 1.2 1 0 0 1 1 1 1 SPRY domain zf-RING_UBOX PF13445.6 EMC87688.1 - 1.7e-10 40.8 9.4 1.7e-10 40.8 9.4 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-B_box PF00643.24 EMC87688.1 - 7e-09 35.7 1.6 7e-09 35.7 1.6 3.1 4 0 0 4 4 3 1 B-box zinc finger zf-C3HC4 PF00097.25 EMC87688.1 - 4e-08 33.0 8.6 4e-08 33.0 8.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMC87688.1 - 1.1e-06 28.4 7.0 1.1e-06 28.4 7.0 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC87688.1 - 2e-06 28.0 10.5 2e-06 28.0 10.5 2.9 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.6 EMC87688.1 - 3.1e-06 27.0 7.9 3.1e-06 27.0 7.9 2.6 2 1 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EMC87688.1 - 6.3e-06 26.3 10.3 6.3e-06 26.3 10.3 2.6 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EMC87688.1 - 0.00014 21.7 12.9 0.00014 21.7 12.9 3.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 EMC87688.1 - 0.0054 16.5 5.8 0.0054 16.5 5.8 2.3 2 1 0 2 2 2 1 RING/Ubox like zinc-binding domain SidE PF12252.8 EMC87688.1 - 0.0061 14.2 2.3 0.008 13.8 2.3 1.0 1 0 0 1 1 1 1 Dot/Icm substrate protein Herpes_IE2_3 PF03361.14 EMC87688.1 - 0.038 13.9 0.0 0.085 12.7 0.0 1.5 1 0 0 1 1 1 0 Herpes virus intermediate/early protein 2/3 U-box PF04564.15 EMC87688.1 - 0.086 13.0 0.0 0.23 11.7 0.0 1.7 1 1 0 1 1 1 0 U-box domain ATP-synt_E_2 PF08112.11 EMC87688.1 - 0.13 12.5 1.7 1.2 9.5 0.3 2.7 1 1 1 2 2 2 0 ATP synthase epsilon subunit RecG_N PF17190.4 EMC87688.1 - 0.39 11.5 3.6 0.66 10.7 2.7 1.9 1 1 0 1 1 1 0 RecG N-terminal helical domain zf-Nse PF11789.8 EMC87688.1 - 0.46 10.4 4.4 1.3 8.9 4.4 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit JAKMIP_CC3 PF16034.5 EMC87688.1 - 0.47 10.4 4.2 0.94 9.4 4.2 1.5 1 1 0 1 1 1 0 JAKMIP CC3 domain zf-RING_11 PF17123.5 EMC87688.1 - 2.6 7.8 7.9 13 5.6 7.9 2.3 1 0 0 1 1 1 0 RING-like zinc finger Prok-RING_4 PF14447.6 EMC87688.1 - 6.6 6.7 21.9 0.24 11.3 12.1 3.2 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 EMC87688.1 - 8.3 6.6 15.2 0.7 10.1 8.8 2.6 1 1 0 1 1 1 0 zinc RING finger of MSL2 BTB_2 PF02214.22 EMC87689.1 - 5.9e-19 68.2 0.2 1.4e-18 67.0 0.2 1.6 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 EMC87689.1 - 0.0019 18.3 0.0 0.0043 17.1 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain DLEU7 PF15760.5 EMC87690.1 - 3.9e-66 222.3 0.7 4.8e-66 222.0 0.7 1.0 1 0 0 1 1 1 1 Leukemia-associated protein 7 RNase_H2-Ydr279 PF09468.10 EMC87691.1 - 4.5e-15 56.2 1.1 4.5e-15 56.2 1.1 1.9 2 1 0 2 2 2 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 EMC87691.1 - 1.4e-09 38.0 0.0 2.9e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain FAM124 PF15067.6 EMC87693.1 - 1.2e-108 362.2 0.0 1.8e-108 361.6 0.0 1.3 1 0 0 1 1 1 1 FAM124 family Serpin PF00079.20 EMC87694.1 - 7.3e-96 321.7 0.8 8.3e-96 321.5 0.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) WD40 PF00400.32 EMC87695.1 - 2e-17 63.2 18.8 3.3e-07 30.9 1.3 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat FYVE PF01363.21 EMC87695.1 - 1.9e-14 53.5 7.8 4.4e-14 52.4 7.8 1.6 1 0 0 1 1 1 1 FYVE zinc finger ANAPC4_WD40 PF12894.7 EMC87695.1 - 3.3e-06 27.3 0.1 0.16 12.3 0.0 3.9 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 EMC87695.1 - 2.9e-05 23.0 0.2 0.33 9.7 0.0 3.1 3 1 0 3 3 3 2 Nup133 N terminal like FYVE_2 PF02318.16 EMC87695.1 - 0.036 14.3 4.3 0.084 13.1 4.3 1.6 1 0 0 1 1 1 0 FYVE-type zinc finger DUF2688 PF10892.8 EMC87695.1 - 0.18 11.3 5.0 0.63 9.6 5.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2688) DiS_P_DiS PF06750.13 EMC87695.1 - 6.1 7.0 7.6 49 4.1 6.8 2.7 2 1 0 2 2 2 0 Bacterial Peptidase A24 N-terminal domain adh_short PF00106.25 EMC87696.1 - 1.7e-26 92.9 0.6 2.6e-25 89.0 0.5 2.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC87696.1 - 3.9e-18 65.9 0.3 5.8e-17 62.0 0.2 2.3 2 1 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC87696.1 - 6.7e-10 39.2 0.2 1.1e-09 38.5 0.2 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EMC87696.1 - 2.6e-06 27.1 0.1 3.4e-06 26.7 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EMC87696.1 - 0.00063 19.2 0.1 0.015 14.6 0.0 2.4 2 1 0 2 2 2 1 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 EMC87696.1 - 0.0011 18.5 0.1 0.0016 17.9 0.1 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EMC87696.1 - 0.0072 16.2 2.6 0.019 14.9 1.3 2.3 1 1 0 2 2 2 1 NAD(P)H-binding LDcluster4 PF18306.1 EMC87696.1 - 0.027 14.1 0.2 0.15 11.6 0.3 1.9 2 0 0 2 2 2 0 SLOG cluster4 family Mucin-like PF16058.5 EMC87697.1 - 4.3e-25 87.7 116.4 1.4e-06 28.3 25.6 4.1 1 1 3 4 4 4 4 Mucin-like TssO PF17561.2 EMC87698.1 - 0.0026 17.9 1.8 0.0026 17.9 1.8 1.6 2 0 0 2 2 2 1 Type VI secretion system, TssO MscS_porin PF12795.7 EMC87698.1 - 0.0094 15.5 2.3 0.019 14.5 2.3 1.5 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain YabA PF06156.13 EMC87698.1 - 0.031 14.9 3.6 0.055 14.1 0.2 2.2 1 1 1 2 2 2 0 Initiation control protein YabA COG2 PF06148.11 EMC87698.1 - 0.032 14.3 0.4 0.032 14.3 0.4 1.7 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 CRM1_C PF08767.11 EMC87698.1 - 0.058 12.6 1.0 0.082 12.1 1.0 1.2 1 0 0 1 1 1 0 CRM1 C terminal DUF713 PF05218.14 EMC87698.1 - 0.058 13.1 12.3 0.098 12.4 12.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF713) Glyco_transf_29 PF00777.18 EMC87698.1 - 0.066 12.6 1.0 0.094 12.1 1.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 29 (sialyltransferase) LRS4 PF10422.9 EMC87698.1 - 0.49 9.9 2.8 0.82 9.2 2.8 1.3 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 HMA PF00403.26 EMC87699.1 - 2.4e-83 274.5 3.0 6.2e-16 58.6 0.0 6.8 6 0 0 6 6 6 6 Heavy-metal-associated domain Hydrolase PF00702.26 EMC87699.1 - 3.9e-62 210.3 1.3 9e-62 209.1 1.3 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EMC87699.1 - 3.6e-46 157.0 4.1 3.6e-46 157.0 4.1 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EMC87699.1 - 2.8e-07 30.5 2.6 4.8e-05 23.2 0.3 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EMC87699.1 - 0.0004 20.5 0.9 0.011 15.8 0.1 3.1 3 0 0 3 3 3 1 Haloacid dehalogenase-like hydrolase RRM_3 PF08777.11 EMC87699.1 - 0.0017 18.4 0.1 0.92 9.6 0.0 4.3 5 0 0 5 5 5 1 RNA binding motif HAD_2 PF13419.6 EMC87699.1 - 0.0033 17.5 0.1 0.0094 16.1 0.1 1.7 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 EMC87699.1 - 0.028 14.8 0.0 0.057 13.8 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase SapB_2 PF03489.17 EMC87699.1 - 0.028 14.5 0.3 0.09 12.9 0.3 2.0 1 0 0 1 1 1 0 Saposin-like type B, region 2 Fer2_BFD PF04324.15 EMC87699.1 - 0.14 12.5 12.7 46 4.5 0.1 6.4 6 0 0 6 6 6 0 BFD-like [2Fe-2S] binding domain DUF2200 PF09966.9 EMC87699.1 - 0.6 10.3 7.2 13 6.0 0.0 4.9 5 0 0 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2200) GFA PF04828.14 EMC87699.1 - 2.6 8.4 10.1 15 6.0 0.0 5.0 6 0 0 6 6 6 0 Glutathione-dependent formaldehyde-activating enzyme ALG11_N PF15924.5 EMC87700.1 - 1.2e-89 299.9 0.1 1.5e-89 299.6 0.1 1.1 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 EMC87700.1 - 1.1e-29 103.1 0.0 2e-29 102.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EMC87700.1 - 4.6e-14 53.0 0.0 1.2e-13 51.7 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EMC87700.1 - 0.00041 20.7 0.0 0.00079 19.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EMC87700.1 - 0.00094 19.2 0.0 0.0025 17.8 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Pkinase PF00069.25 EMC87701.1 - 3.1e-69 233.3 0.2 3.1e-69 233.3 0.2 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87701.1 - 1e-48 165.9 0.1 1e-48 165.9 0.1 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC87701.1 - 5.9e-07 29.1 0.1 5.1e-05 22.7 0.0 2.4 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EMC87701.1 - 3.4e-05 22.8 0.4 6.5e-05 21.9 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Pkinase PF00069.25 EMC87702.1 - 1.4e-66 224.6 0.0 2.1e-66 224.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87702.1 - 1e-44 152.8 0.0 1.6e-44 152.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC87702.1 - 1.3e-08 34.5 0.1 1.1e-07 31.4 0.0 2.1 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 EMC87702.1 - 0.002 18.1 0.0 1.6 8.6 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EMC87702.1 - 0.039 12.7 0.1 0.11 11.2 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase LPD24 PF18839.1 EMC87702.1 - 0.14 12.4 0.5 14 6.1 0.1 2.6 2 0 0 2 2 2 0 Large polyvalent protein associated domain 24 Kdo PF06293.14 EMC87702.1 - 0.21 10.9 1.5 0.26 10.6 0.4 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family EAP30 PF04157.16 EMC87703.1 - 1.6e-42 145.5 1.2 2.2e-42 145.0 1.2 1.2 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.8 EMC87703.1 - 0.0025 18.0 0.0 0.0054 16.9 0.0 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 GRAM PF02893.20 EMC87703.1 - 0.009 15.9 0.1 0.024 14.5 0.0 1.8 2 0 0 2 2 2 1 GRAM domain BBL5 PF07289.11 EMC87703.1 - 0.028 13.5 0.0 0.14 11.2 0.0 1.9 2 0 0 2 2 2 0 Bardet-Biedl syndrome 5 protein TssO PF17561.2 EMC87703.1 - 0.035 14.2 1.2 0.062 13.4 1.2 1.3 1 0 0 1 1 1 0 Type VI secretion system, TssO TTRAP PF14203.6 EMC87703.1 - 0.13 12.2 4.6 0.19 11.7 1.9 2.2 2 0 0 2 2 2 0 Putative tranposon-transfer assisting protein SpmSyn_N PF17950.1 EMC87703.1 - 0.19 12.0 0.8 3.8 7.8 0.0 2.7 2 1 0 2 2 2 0 S-adenosylmethionine decarboxylase N -terminal YtxH PF12732.7 EMC87703.1 - 4 8.0 8.4 2.5 8.7 5.3 2.1 2 0 0 2 2 2 0 YtxH-like protein TSP_1 PF00090.19 EMC87704.1 - 7.1e-11 42.2 8.4 7.1e-11 42.2 8.4 2.4 2 0 0 2 2 2 1 Thrombospondin type 1 domain Fibrinogen_C PF00147.18 EMC87705.1 - 3.9e-73 245.9 15.2 4.6e-73 245.7 15.2 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain PTEN_C2 PF10409.9 EMC87706.1 - 1.9e-26 92.4 0.2 4.1e-26 91.3 0.2 1.6 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein Ion_trans PF00520.31 EMC87706.1 - 6.9e-13 48.4 7.4 1e-12 47.8 7.4 1.3 1 0 0 1 1 1 1 Ion transport protein DSPc PF00782.20 EMC87706.1 - 2.9e-09 36.8 0.0 1.1e-08 35.0 0.0 1.7 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EMC87706.1 - 1.5e-05 25.1 0.0 2.8e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 EMC87706.1 - 0.00011 21.9 0.0 0.00018 21.2 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PKD_channel PF08016.12 EMC87706.1 - 0.0015 17.3 1.4 0.0015 17.3 1.4 1.5 1 1 0 1 1 1 1 Polycystin cation channel Y_phosphatase3 PF13350.6 EMC87706.1 - 0.032 14.2 0.0 0.056 13.4 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF4282 PF14110.6 EMC87706.1 - 2.2 9.1 9.4 0.17 12.6 4.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4282) Mito_carr PF00153.27 EMC87707.1 - 5.3e-62 205.8 5.0 4.3e-21 74.6 0.3 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein MRP-S31 PF15433.6 EMC87708.1 - 9.9e-71 239.0 6.8 1.1e-70 238.9 6.8 1.0 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S31 FOXO_KIX_bdg PF16675.5 EMC87709.1 - 3.4e-30 104.2 1.6 3.4e-30 104.2 1.6 2.7 2 0 0 2 2 2 1 KIX-binding domain of forkhead box O, CR2 FOXO-TAD PF16676.5 EMC87709.1 - 6.6e-21 74.4 8.6 1.4e-20 73.4 8.6 1.6 1 0 0 1 1 1 1 Transactivation domain of FOXO protein family Forkhead PF00250.18 EMC87709.1 - 2.2e-08 34.2 0.2 4.9e-08 33.1 0.2 1.6 1 0 0 1 1 1 1 Forkhead domain COG6 PF06419.11 EMC87710.1 - 9e-212 704.7 9.7 1e-211 704.5 9.7 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 Sec34 PF04136.15 EMC87710.1 - 0.0055 16.6 1.6 0.017 15.0 1.6 1.9 1 0 0 1 1 1 1 Sec34-like family YabA PF06156.13 EMC87710.1 - 0.0067 17.0 1.2 0.03 14.9 1.2 2.2 1 0 0 1 1 1 1 Initiation control protein YabA SOGA PF11365.8 EMC87710.1 - 0.025 15.7 3.8 0.033 15.3 1.5 2.5 2 0 0 2 2 2 0 Protein SOGA Jnk-SapK_ap_N PF09744.9 EMC87710.1 - 0.032 14.4 3.0 0.11 12.7 3.0 2.0 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Takusan PF04822.13 EMC87710.1 - 0.088 12.7 2.1 0.16 11.9 0.5 2.3 2 0 0 2 2 2 0 Takusan Mod_r PF07200.13 EMC87710.1 - 0.34 11.0 9.5 13 5.8 4.7 2.8 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein BLOC1_2 PF10046.9 EMC87710.1 - 0.51 10.7 5.8 0.2 12.0 2.1 2.3 2 1 1 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1043 PF06295.12 EMC87710.1 - 0.67 10.0 3.7 0.7 9.9 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) Nup54 PF13874.6 EMC87710.1 - 0.75 9.9 4.3 0.68 10.0 1.4 2.4 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 GLTSCR1 PF15249.6 EMC87710.1 - 0.82 10.1 4.0 0.75 10.3 1.5 2.1 1 1 1 2 2 2 0 Conserved region of unknown function on GLTSCR protein Syntaxin-6_N PF09177.11 EMC87710.1 - 1.2 9.7 4.3 20 5.8 2.4 3.0 2 1 0 2 2 2 0 Syntaxin 6, N-terminal TSNAXIP1_N PF15739.5 EMC87710.1 - 3.5 8.0 7.6 12 6.4 3.6 3.0 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus L_HMGIC_fpl PF10242.9 EMC87711.1 - 2e-30 106.4 5.0 2.4e-30 106.1 5.0 1.0 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein UPF0016 PF01169.19 EMC87711.1 - 0.073 13.4 1.2 0.073 13.4 1.2 1.8 2 0 0 2 2 2 0 Uncharacterized protein family UPF0016 L_HMGIC_fpl PF10242.9 EMC87712.1 - 3.8e-11 43.5 0.1 8.2e-11 42.4 0.1 1.5 1 1 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein NHL PF01436.21 EMC87713.1 - 3e-12 45.9 3.0 2.8e-07 30.2 0.1 5.0 6 0 0 6 6 6 2 NHL repeat SGL PF08450.12 EMC87713.1 - 0.00027 20.6 0.6 0.04 13.5 0.1 3.1 3 2 0 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region Tachylectin PF14517.6 EMC87713.1 - 0.00088 18.9 0.2 0.0017 18.0 0.2 1.6 1 0 0 1 1 1 1 Tachylectin Proteasome_A_N PF10584.9 EMC87713.1 - 0.045 13.4 0.1 0.13 12.0 0.0 1.9 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature DUF4476 PF14771.6 EMC87714.1 - 1.9e-23 82.6 0.3 3.4e-23 81.7 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4476) Band_7 PF01145.25 EMC87715.1 - 1.3e-29 103.5 2.2 1.6e-29 103.2 2.2 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 EMC87715.1 - 0.01 15.6 0.1 0.017 14.8 0.1 1.4 1 0 0 1 1 1 0 SPFH domain-Band 7 family TED_complement PF07678.14 EMC87716.1 - 1.7e-87 293.4 2.6 3.9e-87 292.2 2.6 1.6 1 1 0 1 1 1 1 A-macroglobulin TED domain A2M PF00207.22 EMC87716.1 - 2e-29 101.3 0.7 6.4e-29 99.7 0.3 2.2 2 0 0 2 2 2 1 Alpha-2-macroglobulin family A2M_BRD PF07703.14 EMC87716.1 - 7.1e-26 91.2 0.8 5e-22 78.8 0.0 3.8 3 0 0 3 3 3 2 Alpha-2-macroglobulin bait region domain NTR PF01759.21 EMC87716.1 - 1.9e-23 82.3 0.6 5.7e-23 80.8 0.6 1.9 1 0 0 1 1 1 1 UNC-6/NTR/C345C module A2M_recep PF07677.14 EMC87716.1 - 3.8e-23 82.0 2.2 4.5e-22 78.5 0.0 3.5 3 0 0 3 3 3 1 A-macroglobulin receptor binding domain MG1 PF17790.1 EMC87716.1 - 2.4e-19 69.6 0.5 9.6e-19 67.7 0.5 2.2 1 0 0 1 1 1 1 Macroglobulin domain MG1 MG2 PF01835.19 EMC87716.1 - 4.2e-19 68.8 0.1 3.8e-14 52.9 0.0 4.7 4 0 0 4 4 4 2 MG2 domain MG3 PF17791.1 EMC87716.1 - 1.5e-14 54.0 0.0 5.9e-14 52.1 0.0 2.1 1 0 0 1 1 1 1 Macroglobulin domain MG3 MG4 PF17789.1 EMC87716.1 - 3.7e-13 49.4 0.3 1.9e-12 47.1 0.1 2.4 2 0 0 2 2 2 1 Macroglobulin domain MG4 ANATO PF01821.18 EMC87716.1 - 7.2e-13 49.2 8.7 7.2e-13 49.2 8.7 2.0 2 0 0 2 2 2 1 Anaphylotoxin-like domain Ufm1 PF03671.14 EMC87717.1 - 6.4e-43 144.7 0.1 7.2e-43 144.6 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin fold modifier 1 protein Ion_trans PF00520.31 EMC87718.1 - 3.1e-33 115.0 14.4 4.7e-33 114.4 14.4 1.2 1 0 0 1 1 1 1 Ion transport protein TRP_2 PF08344.11 EMC87718.1 - 1.1e-28 99.2 0.8 2.8e-28 97.9 0.8 1.8 1 0 0 1 1 1 1 Transient receptor ion channel II Ank_2 PF12796.7 EMC87718.1 - 6.1e-10 39.6 0.6 2.2e-05 25.0 0.4 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC87718.1 - 1.7e-09 38.0 0.0 0.00097 19.7 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC87718.1 - 1.5e-06 28.1 2.6 0.13 12.9 0.1 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EMC87718.1 - 6.7e-05 23.1 0.1 1.1 9.6 0.1 3.5 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EMC87718.1 - 0.00015 22.1 0.4 1 9.9 0.0 3.2 2 0 0 2 2 2 2 Ankyrin repeat PKD_channel PF08016.12 EMC87718.1 - 0.00046 19.0 15.7 0.005 15.6 15.7 2.3 1 1 0 1 1 1 1 Polycystin cation channel Gp-FAR-1 PF05823.12 EMC87718.1 - 0.46 10.8 4.9 7.1 7.0 0.1 2.9 3 0 0 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Fasciclin PF02469.22 EMC87719.1 - 8.9e-105 346.0 0.1 3.1e-27 95.3 0.4 4.4 4 0 0 4 4 4 4 Fasciclin domain MTCP1 PF08991.10 EMC87719.1 - 0.37 11.1 1.1 0.74 10.1 1.1 1.4 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type Pkinase PF00069.25 EMC87720.1 - 1.3e-36 126.4 0.0 1.4e-36 126.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87720.1 - 1.8e-27 96.3 0.0 2.1e-27 96.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase NAD_Gly3P_dh_N PF01210.23 EMC87720.1 - 0.14 12.1 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus APH PF01636.23 EMC87720.1 - 0.21 11.5 0.0 0.28 11.1 0.0 1.3 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 EMC87721.1 - 1.1e-43 149.6 0.0 1.1e-43 149.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87721.1 - 1.3e-33 116.4 0.0 1.4e-33 116.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC87721.1 - 0.00013 20.9 0.0 0.00026 19.9 0.0 1.4 1 1 1 2 2 2 1 Fungal protein kinase Fringe PF02434.16 EMC87723.1 - 9.9e-15 54.7 0.7 4.6e-14 52.5 0.7 1.9 1 1 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 EMC87723.1 - 1.7e-09 37.8 0.5 4e-05 23.5 0.3 2.2 1 1 1 2 2 2 2 Galactosyltransferase Asn_synthase PF00733.21 EMC87724.1 - 1.3e-81 275.1 0.4 6.6e-45 154.3 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 EMC87724.1 - 9.9e-26 90.1 0.0 1.8e-25 89.2 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EMC87724.1 - 5.6e-19 68.7 0.0 1.1e-18 67.7 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EMC87724.1 - 3.1e-08 33.4 0.0 6e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Aluminium induced protein Tachykinin PF02202.16 EMC87725.1 - 2.5e-10 39.2 1.1 0.00084 19.0 0.9 2.4 2 0 0 2 2 2 2 Tachykinin family DLL_N PF12413.8 EMC87727.1 - 3.4e-26 92.3 23.1 3.4e-26 92.3 23.1 2.0 2 0 0 2 2 2 1 Homeobox protein distal-less-like N terminal Homeodomain PF00046.29 EMC87727.1 - 3.2e-20 71.7 2.5 4.9e-20 71.1 2.5 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC87727.1 - 0.0063 16.4 0.1 0.014 15.3 0.1 1.6 1 0 0 1 1 1 1 Homeobox KN domain YdaS_antitoxin PF15943.5 EMC87727.1 - 0.065 13.1 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT DSS1_SEM1 PF05160.13 EMC87728.1 - 7.7e-14 51.5 9.8 8.9e-14 51.3 9.8 1.1 1 0 0 1 1 1 1 DSS1/SEM1 family Mito_carr PF00153.27 EMC87729.1 - 3e-73 241.8 0.5 1.5e-26 92.2 0.0 3.5 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 EMC87729.1 - 9.3e-09 35.6 0.6 0.0017 18.8 0.0 4.8 3 2 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 EMC87729.1 - 2.2e-08 33.1 3.8 0.031 13.8 0.1 4.9 5 0 0 5 5 5 2 EF hand EF-hand_6 PF13405.6 EMC87729.1 - 1.1e-07 31.2 1.5 0.0083 16.0 0.1 5.1 5 0 0 5 5 5 2 EF-hand domain EF-hand_8 PF13833.6 EMC87729.1 - 7.2e-07 29.0 0.6 0.11 12.4 0.0 4.2 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 EMC87729.1 - 4.3e-05 22.8 0.1 0.94 9.1 0.0 3.9 3 0 0 3 3 3 2 EF hand Dynein_IC2 PF11540.8 EMC87730.1 - 1.2e-14 53.9 0.1 3e-14 52.7 0.1 1.7 1 0 0 1 1 1 1 Cytoplasmic dynein 1 intermediate chain 2 WD40 PF00400.32 EMC87730.1 - 4.1e-07 30.6 8.8 0.11 13.5 0.3 6.2 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC87730.1 - 0.1 12.9 0.2 1.3 9.4 0.0 2.7 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain SpoIIP PF07454.11 EMC87730.1 - 2.5 7.5 8.4 5.8 6.3 1.4 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) BCDHK_Adom3 PF10436.9 EMC87731.1 - 8.8e-48 162.2 0.0 1.2e-47 161.7 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EMC87731.1 - 2.1e-13 50.7 0.0 3.7e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EMC87731.1 - 0.0019 18.0 0.0 0.0033 17.3 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ank_2 PF12796.7 EMC87732.1 - 1.7e-27 95.8 24.9 7.6e-12 45.7 1.2 4.5 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC87732.1 - 1.9e-21 76.1 9.0 8.3e-07 29.4 0.3 6.7 2 1 5 7 7 7 4 Ankyrin repeats (many copies) Ank PF00023.30 EMC87732.1 - 1.7e-17 63.0 12.6 0.065 13.7 0.0 7.5 7 0 0 7 7 7 6 Ankyrin repeat Ank_3 PF13606.6 EMC87732.1 - 1.4e-16 58.9 14.3 0.033 14.7 0.0 8.9 9 1 0 9 9 9 5 Ankyrin repeat Ank_5 PF13857.6 EMC87732.1 - 4.8e-15 55.4 10.7 0.00039 20.7 0.3 4.6 3 1 1 4 4 4 4 Ankyrin repeats (many copies) SOCS_box PF07525.16 EMC87732.1 - 3.4e-11 43.3 5.0 7.8e-11 42.1 5.0 1.7 1 0 0 1 1 1 1 SOCS box ADAM_CR PF08516.12 EMC87732.1 - 0.14 12.6 2.5 0.36 11.2 2.5 1.7 1 0 0 1 1 1 0 ADAM cysteine-rich Arylesterase PF01731.20 EMC87733.1 - 3.5e-41 139.3 1.4 6.1e-41 138.5 1.4 1.4 1 0 0 1 1 1 1 Arylesterase SGL PF08450.12 EMC87733.1 - 2.4e-08 33.9 0.0 3.3e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 EMC87733.1 - 0.00016 21.8 0.0 0.00041 20.4 0.0 1.6 1 0 0 1 1 1 1 Strictosidine synthase Glyco_hydro_42C PF08533.10 EMC87733.1 - 0.13 12.0 0.1 0.43 10.3 0.1 1.9 1 1 0 1 1 1 0 Beta-galactosidase C-terminal domain PDZ_5 PF17817.1 EMC87734.1 - 5e-28 97.2 2.2 3.4e-27 94.5 2.2 2.6 1 0 0 1 1 1 1 PDZ domain SAM_2 PF07647.17 EMC87734.1 - 1.4e-16 60.4 0.8 3.2e-16 59.2 0.8 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDZ PF00595.24 EMC87734.1 - 7.3e-14 51.9 1.8 1.8e-13 50.6 1.8 1.7 1 0 0 1 1 1 1 PDZ domain SAM_1 PF00536.30 EMC87734.1 - 8.4e-14 51.8 1.0 1.9e-13 50.6 1.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDZ_6 PF17820.1 EMC87734.1 - 9.3e-07 28.6 0.9 7.3e-06 25.7 0.3 2.8 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 EMC87734.1 - 0.0033 17.7 0.8 0.014 15.7 0.4 2.3 2 0 0 2 2 2 1 PDZ domain SAM_PNT PF02198.16 EMC87734.1 - 0.012 15.6 0.1 0.037 14.0 0.1 1.8 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Pox_A_type_inc PF04508.12 EMC87734.1 - 0.012 15.4 0.6 6.4 6.8 0.0 3.2 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Sarcoglycan_2 PF05510.13 EMC87735.1 - 1.3e-127 425.8 0.0 1.5e-127 425.5 0.0 1.0 1 0 0 1 1 1 1 Sarcoglycan alpha/epsilon Cas1_AcylT PF07779.12 EMC87736.1 - 3.6e-217 721.9 27.2 4.4e-217 721.7 27.2 1.1 1 0 0 1 1 1 1 10 TM Acyl Transferase domain found in Cas1p PC-Esterase PF13839.6 EMC87736.1 - 0.034 13.9 0.0 0.077 12.7 0.0 1.5 1 0 0 1 1 1 0 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p Collagen PF01391.18 EMC87737.1 - 9.1e-167 541.0 677.1 6e-10 38.7 34.2 20.9 2 1 13 15 15 15 12 Collagen triple helix repeat (20 copies) COLFI PF01410.18 EMC87737.1 - 9.7e-108 358.8 0.1 1.2e-107 358.6 0.1 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Sec20 PF03908.13 EMC87739.1 - 0.00052 19.9 0.1 0.00068 19.5 0.1 1.2 1 0 0 1 1 1 1 Sec20 Use1 PF09753.9 EMC87739.1 - 0.0014 18.4 0.0 0.0018 18.1 0.0 1.2 1 0 0 1 1 1 1 Membrane fusion protein Use1 DUF4407 PF14362.6 EMC87739.1 - 0.029 13.7 0.0 0.036 13.4 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) APG17 PF04108.12 EMC87739.1 - 0.082 12.0 0.0 0.099 11.7 0.0 1.0 1 0 0 1 1 1 0 Autophagy protein Apg17 MCPsignal PF00015.21 EMC87739.1 - 0.082 12.7 0.0 0.099 12.4 0.0 1.0 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain G-gamma PF00631.22 EMC87740.1 - 9.5e-16 57.6 2.4 1.1e-14 54.1 2.4 1.9 1 1 0 1 1 1 1 GGL domain RelB_leu_zip PF16180.5 EMC87740.1 - 0.041 13.9 0.0 0.053 13.5 0.0 1.3 1 0 0 1 1 1 0 RelB leucine zipper HAUS5 PF14817.6 EMC87740.1 - 0.073 11.8 0.6 0.085 11.6 0.6 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 tRNA_bind_4 PF18490.1 EMC87740.1 - 0.08 12.7 0.1 0.14 11.9 0.0 1.5 1 1 0 1 1 1 0 tRNA-binding domain Kunitz_BPTI PF00014.23 EMC87741.1 - 2.5e-58 194.1 32.2 4.8e-22 77.9 3.3 3.1 3 0 0 3 3 3 3 Kunitz/Bovine pancreatic trypsin inhibitor domain Prion PF00377.18 EMC87741.1 - 4.8e-05 23.2 1.9 0.0003 20.6 0.1 2.1 2 0 0 2 2 2 1 Prion/Doppel alpha-helical domain 7tm_2 PF00002.24 EMC87742.1 - 1.2e-79 267.1 17.1 1.5e-79 266.7 17.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 EMC87742.1 - 9.7e-20 70.6 7.3 2.2e-19 69.5 7.3 1.6 1 0 0 1 1 1 1 Hormone receptor domain DUF5368 PF17336.2 EMC87742.1 - 5.2 7.3 8.0 0.87 9.8 0.2 2.7 2 1 0 2 2 2 0 Family of unknown function (DUF5368) Vps54_N PF10475.9 EMC87743.1 - 9.3e-100 333.7 11.2 2.3e-99 332.4 11.2 1.7 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 EMC87743.1 - 2.2e-96 322.2 3.1 2.2e-96 322.2 3.1 2.2 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) Ig_3 PF13927.6 EMC87744.1 - 8.5e-22 77.6 0.4 5.1e-12 46.2 0.3 3.5 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 EMC87744.1 - 1.6e-16 60.1 0.0 2.5e-08 33.9 0.0 4.3 4 1 0 4 4 4 3 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC87744.1 - 2.1e-13 50.4 0.4 1.3e-07 31.9 0.1 2.8 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 EMC87744.1 - 7.2e-13 48.5 0.0 3.9e-06 26.9 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 EMC87744.1 - 1.7e-12 47.4 0.0 1.3e-05 25.3 0.0 4.0 3 2 0 3 3 3 2 Immunoglobulin V-set domain Ig_6 PF18452.1 EMC87744.1 - 0.009 15.6 0.0 2.3 7.8 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 EMC87744.1 - 0.055 13.5 0.0 6.3 6.9 0.0 2.4 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain SAM_1 PF00536.30 EMC87745.1 - 0.00029 21.2 0.1 0.0015 18.9 0.1 2.4 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 EMC87745.1 - 0.0084 16.1 0.1 0.054 13.5 0.1 2.3 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain Pkinase PF00069.25 EMC87746.1 - 4.8e-69 232.7 0.0 5.5e-69 232.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87746.1 - 1.3e-35 122.9 0.0 2.5e-35 122.0 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EMC87746.1 - 8.9e-07 29.1 0.2 0.0015 18.5 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EMC87746.1 - 1.8e-05 24.2 0.0 3.5e-05 23.3 0.0 1.4 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EMC87746.1 - 0.00016 20.8 0.0 0.00028 19.9 0.0 1.3 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EMC87746.1 - 0.002 17.5 0.1 0.0039 16.6 0.0 1.5 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 EMC87746.1 - 0.022 14.4 0.0 0.056 13.0 0.0 1.6 1 1 0 1 1 1 0 RIO1 family FTA2 PF13095.6 EMC87746.1 - 0.13 11.9 0.0 0.75 9.4 0.0 2.0 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Sipho_Gp37 PF14594.6 EMC87749.1 - 0.057 12.4 0.0 0.068 12.2 0.0 1.1 1 0 0 1 1 1 0 Siphovirus ReqiPepy6 Gp37-like protein IBR PF01485.21 EMC87750.1 - 1e-20 73.7 20.6 2.1e-13 50.3 1.2 4.6 4 1 1 5 5 5 2 IBR domain, a half RING-finger domain Ank_5 PF13857.6 EMC87750.1 - 8.4e-10 38.7 1.2 0.00019 21.7 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC87750.1 - 1.4e-09 38.4 0.4 7.4e-05 23.3 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EMC87750.1 - 3.7e-09 36.6 0.1 0.0033 17.8 0.0 3.2 3 0 0 3 3 2 2 Ankyrin repeat Ank_4 PF13637.6 EMC87750.1 - 7.2e-07 29.6 0.1 0.0078 16.8 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC87750.1 - 7.5e-07 29.0 0.6 0.013 15.9 0.0 3.6 4 0 0 4 4 3 2 Ankyrin repeat zf-RING_UBOX PF13445.6 EMC87750.1 - 4.5e-05 23.4 30.6 0.00012 22.0 6.4 4.2 3 1 0 3 3 3 2 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EMC87750.1 - 0.00057 19.7 4.9 0.00057 19.7 4.9 4.2 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC87750.1 - 0.0012 19.2 8.7 0.0012 19.2 8.7 4.0 3 1 0 3 3 3 2 Ring finger domain zf-C3HC4_4 PF15227.6 EMC87750.1 - 0.0044 17.2 6.5 0.0044 17.2 6.5 4.2 3 1 1 4 4 4 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 EMC87750.1 - 0.0056 16.5 6.1 0.0056 16.5 6.1 4.1 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) UIM PF02809.20 EMC87750.1 - 0.13 12.3 0.7 0.39 10.7 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin interaction motif NUDIX_5 PF16705.5 EMC87751.1 - 1.8e-82 275.4 0.1 3.1e-82 274.6 0.1 1.4 1 0 0 1 1 1 1 NUDIX, or N-terminal NPxY motif-rich, region of KRIT FERM_M PF00373.18 EMC87751.1 - 9.2e-20 71.2 0.5 2.4e-19 69.9 0.1 2.0 2 0 0 2 2 2 1 FERM central domain Ank_2 PF12796.7 EMC87751.1 - 4.9e-16 59.1 0.1 1.1e-06 29.1 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC87751.1 - 3e-14 52.9 0.3 1.7e-09 37.8 0.0 2.9 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC87751.1 - 7.7e-12 45.5 1.0 1.9e-07 31.5 0.1 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EMC87751.1 - 3.7e-10 39.8 0.2 0.018 15.4 0.0 4.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EMC87751.1 - 8.2e-08 31.9 0.2 0.048 14.2 0.0 4.1 3 0 0 3 3 3 2 Ankyrin repeat p450 PF00067.22 EMC87752.1 - 1.5e-74 251.5 0.0 1.7e-74 251.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Archease PF01951.16 EMC87752.1 - 0.14 12.4 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 Archease protein family (MTH1598/TM1083) Frizzled PF01534.17 EMC87754.1 - 1.1e-103 346.7 10.5 1.3e-103 346.5 10.5 1.0 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Dicty_CAR PF05462.11 EMC87754.1 - 0.0013 18.0 4.7 0.0013 18.0 4.7 1.7 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor DUF3493 PF11998.8 EMC87754.1 - 0.11 12.6 0.1 0.25 11.6 0.1 1.5 1 0 0 1 1 1 0 Low psii accumulation1 / Rep27 DUF2269 PF10027.9 EMC87754.1 - 2 8.5 11.0 0.2 11.7 0.4 2.5 1 1 1 2 2 2 0 Predicted integral membrane protein (DUF2269) Pkinase PF00069.25 EMC87755.1 - 1.7e-67 227.6 0.0 2.2e-67 227.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87755.1 - 3.2e-32 111.8 0.0 4.9e-32 111.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EMC87755.1 - 3.7e-05 22.8 0.0 0.00016 20.8 0.0 1.9 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EMC87755.1 - 0.0018 17.7 0.1 0.0045 16.4 0.0 1.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EMC87755.1 - 0.015 15.2 0.0 0.095 12.6 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.6 EMC87755.1 - 0.05 13.2 0.1 6.6 6.3 0.0 2.8 2 1 1 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 FAM163 PF15069.6 EMC87756.1 - 0.00022 21.7 0.8 0.00034 21.1 0.8 1.3 1 0 0 1 1 1 1 FAM163 family EphA2_TM PF14575.6 EMC87756.1 - 0.0008 20.2 0.1 0.0013 19.6 0.1 1.4 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Cadherin_C_2 PF16492.5 EMC87756.1 - 0.001 19.8 0.7 0.0018 19.0 0.7 1.4 1 1 0 1 1 1 1 Cadherin cytoplasmic C-terminal Comm PF15957.5 EMC87756.1 - 0.0066 16.8 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 Commissureless LYRIC PF15686.5 EMC87756.1 - 0.026 14.1 0.1 0.035 13.7 0.1 1.0 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family TMEM154 PF15102.6 EMC87756.1 - 0.048 13.6 0.0 0.062 13.2 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family TssO PF17561.2 EMC87756.1 - 0.058 13.5 0.0 0.069 13.3 0.0 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssO Prominin PF05478.11 EMC87756.1 - 0.086 10.8 5.1 0.11 10.4 5.1 1.1 1 0 0 1 1 1 0 Prominin CCER1 PF15482.6 EMC87756.1 - 0.11 12.4 2.8 0.09 12.7 2.0 1.3 1 1 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 DUF4500 PF14937.6 EMC87756.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4500) Synaphin PF05835.12 EMC87756.1 - 0.76 10.0 9.9 1 9.6 9.9 1.1 1 0 0 1 1 1 0 Synaphin protein MMR_HSR1 PF01926.23 EMC87758.1 - 5e-24 84.6 0.0 9.2e-24 83.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP1_OBG PF01018.22 EMC87758.1 - 3.9e-18 65.5 4.0 2.3e-17 63.0 4.0 2.0 1 1 0 1 1 1 1 GTP1/OBG FeoB_N PF02421.18 EMC87758.1 - 3.6e-12 46.1 0.1 2.6e-11 43.3 0.0 2.3 2 1 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EMC87758.1 - 6.2e-05 22.6 0.0 0.0061 16.1 0.1 2.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 EMC87758.1 - 0.00036 19.6 0.1 0.22 10.5 0.0 2.2 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP_bind_1 PF03029.17 EMC87758.1 - 0.018 14.8 0.4 0.11 12.2 0.2 2.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 EMC87758.1 - 0.034 14.2 1.0 7.6 6.6 0.0 2.7 1 1 1 2 2 2 0 Dynamin family F420_oxidored PF03807.17 EMC87761.1 - 4.7e-18 65.6 0.0 8.9e-18 64.7 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Ferric_reduct PF01794.19 EMC87761.1 - 9.1e-16 58.1 8.8 7.2e-15 55.2 5.1 2.4 1 1 1 2 2 2 2 Ferric reductase like transmembrane component NAD_binding_2 PF03446.15 EMC87761.1 - 4.8e-05 23.6 0.0 8.1e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EMC87761.1 - 0.0011 18.4 0.0 0.0018 17.6 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EMC87761.1 - 0.014 15.4 0.0 0.023 14.7 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF2768 PF10966.8 EMC87761.1 - 0.043 14.3 3.0 0.17 12.3 3.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2768) IlvN PF07991.12 EMC87761.1 - 0.083 12.5 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_7 PF13241.6 EMC87761.1 - 0.092 13.2 0.0 0.34 11.4 0.0 1.9 1 1 0 1 1 1 0 Putative NAD(P)-binding DUF997 PF06196.12 EMC87761.1 - 0.78 9.8 6.1 2 8.5 0.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF997) Ferric_reduct PF01794.19 EMC87762.1 - 4.4e-12 46.2 19.0 1.9e-11 44.1 5.3 3.0 2 1 1 3 3 3 2 Ferric reductase like transmembrane component TMEM132D_C PF15706.5 EMC87762.1 - 0.015 15.0 0.5 2.8 7.8 0.3 2.6 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF999 PF06198.11 EMC87762.1 - 1 9.4 5.6 0.78 9.7 1.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF999) Ferric_reduct PF01794.19 EMC87763.1 - 2.3e-13 50.3 5.0 2.3e-13 50.3 5.0 1.9 2 1 0 2 2 2 1 Ferric reductase like transmembrane component F420_oxidored PF03807.17 EMC87763.1 - 4.6e-12 46.4 0.0 8e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.12 EMC87763.1 - 0.00014 21.5 0.0 0.00023 20.8 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_2 PF03446.15 EMC87763.1 - 0.001 19.3 0.0 0.0015 18.7 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EMC87763.1 - 0.003 16.9 0.0 0.005 16.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 EMC87763.1 - 0.085 12.8 0.0 0.51 10.3 0.0 2.0 1 1 1 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Rossmann-like PF10727.9 EMC87763.1 - 0.15 11.9 0.0 0.36 10.7 0.0 1.6 1 1 0 1 1 1 0 Rossmann-like domain EF-hand_1 PF00036.32 EMC87764.1 - 3.5e-17 60.6 0.6 0.00044 19.6 0.0 5.4 5 1 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 EMC87764.1 - 1.3e-13 50.6 1.3 7.7e-10 38.5 0.0 3.3 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EMC87764.1 - 2.2e-13 48.9 0.3 0.0002 21.0 0.0 4.3 4 1 1 5 5 5 3 EF-hand domain EF-hand_7 PF13499.6 EMC87764.1 - 3.5e-12 46.6 0.2 0.00012 22.4 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EMC87764.1 - 6.4e-12 44.4 1.3 0.0012 18.2 0.1 3.7 4 0 0 4 4 4 3 EF hand VbhA PF18495.1 EMC87764.1 - 0.059 13.2 0.1 15 5.6 0.0 2.5 2 0 0 2 2 2 0 Antitoxin VbhA DUF2835 PF11197.8 EMC87764.1 - 0.065 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2835) Reprolysin PF01421.19 EMC87765.1 - 4.1e-61 206.4 0.0 1.2e-60 204.9 0.0 1.8 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 EMC87765.1 - 8.5e-28 97.1 7.3 8.5e-28 97.1 7.3 4.0 3 2 0 3 3 3 1 ADAM cysteine-rich Pep_M12B_propep PF01562.19 EMC87765.1 - 2.1e-18 66.9 1.2 2.1e-18 66.9 1.2 1.8 2 0 0 2 2 2 1 Reprolysin family propeptide Disintegrin PF00200.23 EMC87765.1 - 3.5e-15 56.5 30.4 3.5e-15 56.5 30.4 4.1 4 1 0 4 4 4 1 Disintegrin Reprolysin_3 PF13582.6 EMC87765.1 - 8.4e-08 32.8 0.0 1.7e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EMC87765.1 - 2.2e-06 27.9 0.0 7.2e-06 26.3 0.0 1.9 1 0 0 1 1 1 1 Metallo-peptidase family M12 EGF_2 PF07974.13 EMC87765.1 - 0.0013 19.0 10.8 0.0013 19.0 10.8 6.3 4 2 0 4 4 4 1 EGF-like domain ADAM_CR_2 PF17771.1 EMC87765.1 - 0.054 14.0 0.4 0.054 14.0 0.4 6.1 4 1 2 6 6 6 0 ADAM cysteine-rich domain FRP PF18032.1 EMC87765.1 - 0.19 12.4 0.2 0.39 11.4 0.2 1.4 1 0 0 1 1 1 0 Photoprotection regulator fluorescence recovery protein zf-DBF PF07535.12 EMC87766.1 - 1.4e-17 63.5 2.7 3.6e-17 62.2 2.7 1.8 1 0 0 1 1 1 1 DBF zinc finger BRCT PF00533.26 EMC87766.1 - 0.0073 16.7 0.1 0.036 14.4 0.1 2.3 1 1 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain zf-C2H2_2 PF12756.7 EMC87766.1 - 0.15 12.4 3.5 0.22 11.9 0.8 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) DnaI_N PF07319.11 EMC87766.1 - 0.75 10.5 3.8 1.7 9.4 0.5 2.9 3 0 0 3 3 3 0 Primosomal protein DnaI N-terminus Mito_carr PF00153.27 EMC87767.1 - 2.1e-62 207.0 0.3 2.5e-21 75.4 0.0 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein DX PF01666.17 EMC87767.1 - 0.1 13.0 1.1 0.17 12.3 1.1 1.4 1 0 0 1 1 1 0 DX module RUN PF02759.19 EMC87768.1 - 3.8e-25 88.4 0.1 1.1e-24 86.9 0.0 1.8 2 0 0 2 2 2 1 RUN domain DUF4477 PF14780.6 EMC87768.1 - 0.017 14.8 0.2 0.074 12.7 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4477) Drf_FH3 PF06367.16 EMC87768.1 - 0.1 12.2 6.2 0.22 11.1 6.2 1.6 1 0 0 1 1 1 0 Diaphanous FH3 Domain ABC_membrane PF00664.23 EMC87769.1 - 6.1e-156 518.0 34.6 1.7e-87 293.6 12.4 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EMC87769.1 - 2.3e-75 251.6 0.3 4.2e-37 127.7 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EMC87769.1 - 7.9e-17 61.4 1.9 5e-08 32.7 0.5 3.6 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EMC87769.1 - 2.8e-09 37.6 1.1 0.0025 18.2 0.0 3.0 2 1 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.9 EMC87769.1 - 5.9e-08 31.9 3.9 0.00023 20.1 0.0 3.2 5 0 0 5 5 5 2 Predicted ATPase of the ABC class AAA_22 PF13401.6 EMC87769.1 - 1.9e-07 31.4 1.6 0.029 14.7 0.2 3.4 2 2 0 2 2 2 2 AAA domain AAA_15 PF13175.6 EMC87769.1 - 2.2e-07 31.0 0.1 0.013 15.3 0.1 2.6 2 0 0 2 2 2 2 AAA ATPase domain Zeta_toxin PF06414.12 EMC87769.1 - 4.9e-07 29.2 0.2 0.0018 17.6 0.0 3.4 3 0 0 3 3 3 1 Zeta toxin G-alpha PF00503.20 EMC87769.1 - 4.2e-06 26.2 0.0 0.032 13.4 0.0 2.4 2 0 0 2 2 2 2 G-protein alpha subunit RsgA_GTPase PF03193.16 EMC87769.1 - 4.9e-06 26.5 0.0 0.054 13.4 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA PF00004.29 EMC87769.1 - 1.6e-05 25.3 4.2 0.42 11.0 1.1 4.4 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EMC87769.1 - 1.7e-05 24.8 0.7 0.13 12.2 0.0 2.8 2 1 0 2 2 2 2 Rad17 P-loop domain AAA_5 PF07728.14 EMC87769.1 - 1.9e-05 24.7 0.5 0.56 10.2 0.0 3.8 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 EMC87769.1 - 6.6e-05 22.6 0.6 0.21 11.4 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF87 PF01935.17 EMC87769.1 - 9.5e-05 22.6 3.2 0.076 13.1 0.4 3.7 3 1 0 3 3 3 1 Helicase HerA, central domain AAA_30 PF13604.6 EMC87769.1 - 0.0001 22.1 1.6 0.18 11.5 0.4 3.1 2 2 0 2 2 2 2 AAA domain SbcCD_C PF13558.6 EMC87769.1 - 0.00022 21.4 4.4 0.52 10.6 0.5 3.9 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_28 PF13521.6 EMC87769.1 - 0.00036 20.8 3.1 0.75 10.0 0.5 3.7 2 2 1 4 4 4 2 AAA domain AAA_7 PF12775.7 EMC87769.1 - 0.00076 19.0 0.0 1.1 8.8 0.1 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region PRK PF00485.18 EMC87769.1 - 0.00081 19.2 0.0 1.5 8.5 0.0 2.5 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family AAA_21 PF13304.6 EMC87769.1 - 0.0013 18.6 0.1 5.4 6.7 0.0 4.1 4 0 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system ATP-synt_ab PF00006.25 EMC87769.1 - 0.0027 17.4 1.1 3.5 7.2 0.5 3.0 2 1 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain DUF815 PF05673.13 EMC87769.1 - 0.0048 16.1 0.0 0.91 8.6 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 EMC87769.1 - 0.005 17.2 0.0 7 7.1 0.0 3.1 2 0 0 2 2 2 0 RNA helicase RepB-RCR_reg PF10723.9 EMC87769.1 - 0.0066 16.4 0.7 13 5.8 0.0 3.5 3 0 0 3 3 3 0 Replication regulatory protein RepB AAA_24 PF13479.6 EMC87769.1 - 0.0081 15.9 0.0 2.1 8.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain APS_kinase PF01583.20 EMC87769.1 - 0.014 15.3 0.2 2.6 7.9 0.0 2.6 2 0 0 2 2 2 0 Adenylylsulphate kinase tRNA_lig_kinase PF08303.11 EMC87769.1 - 0.014 15.5 0.0 7.6 6.6 0.0 2.8 2 0 0 2 2 2 0 tRNA ligase kinase domain Mg_chelatase PF01078.21 EMC87769.1 - 0.017 14.5 0.0 0.83 9.0 0.0 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 EMC87769.1 - 0.019 15.3 0.4 2.3 8.5 0.1 2.8 3 0 0 3 3 2 0 AAA domain NACHT PF05729.12 EMC87769.1 - 0.031 14.2 0.4 8.9 6.2 0.1 2.5 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.6 EMC87769.1 - 0.034 14.3 0.0 6.3 7.0 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EMC87769.1 - 0.034 14.7 0.0 4.7 7.8 0.0 2.8 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EMC87769.1 - 0.04 13.7 2.6 7.7 6.2 0.0 3.7 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_25 PF13481.6 EMC87769.1 - 0.048 13.2 0.1 2.3 7.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain Strep_SA_rep PF06696.11 EMC87769.1 - 0.15 12.1 0.6 0.44 10.6 0.6 1.9 1 0 0 1 1 1 0 Streptococcal surface antigen repeat AAA_17 PF13207.6 EMC87769.1 - 0.17 12.3 0.9 25 5.3 0.1 3.4 3 0 0 3 3 3 0 AAA domain NB-ARC PF00931.22 EMC87769.1 - 0.22 10.7 2.0 11 5.1 0.1 2.9 4 0 0 4 4 4 0 NB-ARC domain AAA_23 PF13476.6 EMC87769.1 - 0.39 11.2 2.2 35 4.8 0.0 3.2 3 0 0 3 3 2 0 AAA domain Carn_acyltransf PF00755.20 EMC87770.1 - 4.4e-175 583.7 0.0 4.9e-175 583.5 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Thioesterase PF00975.20 EMC87771.1 - 4.7e-45 154.5 0.0 5.8e-45 154.2 0.0 1.0 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_1 PF00561.20 EMC87771.1 - 0.00025 20.8 0.0 0.00039 20.2 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMC87771.1 - 0.011 16.4 0.0 0.034 14.8 0.0 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase family Lipase_3 PF01764.25 EMC87771.1 - 0.025 14.5 0.0 0.039 13.8 0.0 1.2 1 0 0 1 1 1 0 Lipase (class 3) Hydrolase_4 PF12146.8 EMC87771.1 - 0.046 13.0 0.0 0.071 12.4 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 LIDHydrolase PF10230.9 EMC87771.1 - 0.053 13.1 0.0 0.064 12.8 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase ACBP PF00887.19 EMC87772.1 - 2.4e-29 101.4 0.2 2.6e-29 101.3 0.2 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein JmjN PF02375.17 EMC87772.1 - 0.095 12.7 0.3 0.66 10.0 0.1 2.1 2 0 0 2 2 2 0 jmjN domain Ribosomal_L7Ae PF01248.26 EMC87773.1 - 2.3e-08 33.7 0.0 4.6e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 EMC87773.1 - 9.8e-06 25.7 0.0 0.002 18.2 0.0 2.2 2 0 0 2 2 2 2 RNase P subunit Pop3 NMT_C PF02799.15 EMC87775.1 - 1.9e-81 272.6 0.2 3.3e-81 271.8 0.2 1.4 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 EMC87775.1 - 2.7e-76 254.9 0.0 5.3e-76 253.9 0.0 1.5 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_1 PF00583.25 EMC87775.1 - 0.00021 21.5 0.0 0.00039 20.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EMC87775.1 - 0.035 14.2 0.0 0.1 12.7 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMC87775.1 - 0.17 12.3 0.0 0.38 11.2 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain UPF0560 PF10577.9 EMC87776.1 - 0 1305.0 4.9 0 1304.9 4.9 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0560 FAM176 PF14851.6 EMC87776.1 - 0.087 12.5 2.6 8.6 6.0 0.0 2.7 2 0 0 2 2 2 0 FAM176 family Orthoreo_P10 PF07204.11 EMC87776.1 - 0.11 12.5 0.1 0.26 11.3 0.1 1.6 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 Adeno_E3_CR2 PF02439.15 EMC87776.1 - 0.24 11.2 1.5 0.44 10.3 1.5 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 NAD-GH PF10712.9 EMC87776.1 - 0.28 9.6 0.0 0.45 8.9 0.0 1.2 1 0 0 1 1 1 0 NAD-specific glutamate dehydrogenase Integrin_alpha2 PF08441.12 EMC87777.1 - 5.4e-112 375.0 0.5 6.7e-112 374.7 0.5 1.1 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 EMC87777.1 - 3.8e-25 87.7 18.2 1.8e-10 40.8 0.0 5.7 6 0 0 6 6 6 4 FG-GAP repeat VCBS PF13517.6 EMC87777.1 - 4.8e-08 33.5 13.8 0.00029 21.3 0.9 3.9 2 2 3 5 5 5 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.20 EMC87777.1 - 0.00013 21.7 0.3 0.00013 21.7 0.3 2.0 2 0 0 2 2 2 1 Integrin alpha cytoplasmic region LYRIC PF15686.5 EMC87777.1 - 0.065 12.8 0.1 0.12 11.9 0.1 1.4 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family DUF4205 PF13898.6 EMC87778.1 - 1.2e-53 182.3 0.1 4.2e-50 170.6 0.0 2.3 2 1 0 2 2 2 2 Domain of unknown function (DUF4205) CheR PF01739.18 EMC87778.1 - 0.032 13.7 0.1 0.06 12.8 0.1 1.4 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain PTE PF02126.18 EMC87779.1 - 2e-122 408.3 0.0 2.3e-122 408.1 0.0 1.0 1 0 0 1 1 1 1 Phosphotriesterase family TatD_DNase PF01026.21 EMC87779.1 - 2.6e-06 27.0 0.0 3.7e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 TatD related DNase C1q PF00386.21 EMC87780.1 - 2.6e-18 66.5 0.0 2.8e-18 66.3 0.0 1.0 1 0 0 1 1 1 1 C1q domain TNF PF00229.18 EMC87780.1 - 0.12 12.4 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 TNF(Tumour Necrosis Factor) family LRR_8 PF13855.6 EMC87781.1 - 1.1e-27 95.6 37.8 6.5e-09 35.4 4.0 4.0 1 1 5 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 EMC87781.1 - 2.1e-19 69.3 23.2 1.4e-05 25.4 2.9 4.5 2 2 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC87781.1 - 9.2e-09 34.7 18.8 2 9.3 0.2 7.4 7 1 0 7 7 7 5 Leucine Rich Repeat LRR_6 PF13516.6 EMC87781.1 - 3.9e-06 26.5 24.7 4 7.7 0.4 7.3 7 0 0 7 7 7 6 Leucine Rich repeat SMP_LBD PF17047.5 EMC87781.1 - 0.12 11.9 0.0 0.82 9.1 0.0 2.0 2 0 0 2 2 2 0 Synaptotagmin-like mitochondrial-lipid-binding domain CUB PF00431.20 EMC87782.1 - 0 2352.1 14.8 1.7e-33 115.2 0.0 27.0 27 0 0 27 27 27 27 CUB domain CUB_2 PF02408.20 EMC87782.1 - 8.6e-22 77.2 42.4 0.009 15.8 0.2 19.6 21 0 0 21 21 21 10 CUB-like domain zf-H2C2_2 PF13465.6 EMC87785.1 - 1.3e-32 110.7 61.1 1.2e-07 31.8 5.1 8.7 8 0 0 8 8 8 7 Zinc-finger double domain zf-C2H2 PF00096.26 EMC87785.1 - 3.2e-25 87.1 72.8 0.00012 22.4 5.0 8.7 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC87785.1 - 5.4e-16 57.9 69.3 0.0049 17.6 1.0 8.8 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC87785.1 - 2.8e-08 33.8 56.5 0.01 16.1 1.9 9.1 9 0 0 9 9 9 4 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 EMC87785.1 - 3e-08 33.8 1.9 3e-08 33.8 1.9 4.3 4 0 0 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 EMC87785.1 - 3.7e-08 33.5 54.5 0.0087 16.4 0.4 8.4 8 0 0 8 8 8 4 Zinc-finger of C2H2 type Homeodomain PF00046.29 EMC87785.1 - 0.00013 21.7 0.0 0.00072 19.4 0.0 2.3 2 0 0 2 2 2 1 Homeodomain zf-H2C2_5 PF13909.6 EMC87785.1 - 0.0019 17.9 0.4 0.0019 17.9 0.4 6.1 6 1 0 6 6 4 2 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.6 EMC87785.1 - 0.018 15.1 68.2 0.029 14.4 1.5 8.6 8 0 0 8 8 8 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EMC87785.1 - 0.02 15.2 1.1 0.02 15.2 1.1 7.2 4 3 3 7 7 7 0 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 EMC87785.1 - 2.7 7.8 33.6 0.11 12.3 0.5 6.7 7 0 0 7 7 7 0 zinc-finger C2H2-type zinc_ribbon_15 PF17032.5 EMC87785.1 - 3.1 8.6 29.5 0.33 11.7 1.5 5.2 4 1 1 5 5 5 0 zinc-ribbon family zf-RING_7 PF02591.15 EMC87785.1 - 4.2 7.7 8.6 11 6.2 0.0 4.2 4 0 0 4 4 4 0 C4-type zinc ribbon domain Actin_micro PF17003.5 EMC87785.1 - 8.6 5.4 18.8 5.5 6.1 3.6 4.3 2 2 1 3 3 3 0 Putative actin-like family zf-C3HC4_4 PF15227.6 EMC87786.1 - 1.6e-16 60.2 8.9 1.6e-16 60.2 8.9 2.0 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EMC87786.1 - 1.7e-12 47.1 2.8 1.7e-12 47.1 2.8 2.2 2 1 1 3 3 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EMC87786.1 - 3.7e-12 45.9 6.9 3.7e-12 45.9 6.9 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC87786.1 - 2.3e-10 40.2 8.0 2.3e-10 40.2 8.0 2.0 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 EMC87786.1 - 9.8e-10 38.4 0.7 9.8e-10 38.4 0.7 3.3 4 0 0 4 4 4 1 B-box zinc finger zf-C3HC4_3 PF13920.6 EMC87786.1 - 2.4e-08 33.7 10.6 2.6e-08 33.6 4.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC87786.1 - 2.9e-07 30.7 8.0 2.9e-07 30.7 8.0 2.2 2 1 1 3 3 3 1 Ring finger domain zf-RING_5 PF14634.6 EMC87786.1 - 1.6e-06 27.9 6.7 1.6e-06 27.9 6.7 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_10 PF16685.5 EMC87786.1 - 2.7e-06 27.4 2.5 2.7e-06 27.4 2.5 2.1 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-RING_6 PF14835.6 EMC87786.1 - 0.00079 19.2 1.8 0.0017 18.2 1.8 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 EMC87786.1 - 0.0019 18.0 7.0 0.0019 18.0 7.0 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 Baculo_IE-1 PF05290.11 EMC87786.1 - 0.0032 17.4 1.7 0.0032 17.4 1.7 1.5 2 0 0 2 2 2 1 Baculovirus immediate-early protein (IE-0) zf-RING_4 PF14570.6 EMC87786.1 - 0.0068 16.2 7.6 0.0068 16.2 7.6 3.1 3 1 0 3 3 3 1 RING/Ubox like zinc-binding domain U-box PF04564.15 EMC87786.1 - 0.012 15.7 0.0 0.021 15.0 0.0 1.3 1 0 0 1 1 1 0 U-box domain zf-ANAPC11 PF12861.7 EMC87786.1 - 0.21 11.7 8.3 0.048 13.7 3.4 2.3 2 2 1 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RRPl_C4 PF17026.5 EMC87786.1 - 0.21 11.7 3.9 0.31 11.2 0.8 2.5 2 1 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type zf-rbx1 PF12678.7 EMC87786.1 - 0.56 10.5 11.7 0.55 10.6 7.2 2.6 2 1 0 2 2 2 0 RING-H2 zinc finger domain IBR PF01485.21 EMC87786.1 - 6.6 7.0 15.9 2.1 8.6 1.9 3.2 1 1 2 3 3 3 0 IBR domain, a half RING-finger domain PGA2 PF07543.12 EMC87789.1 - 0.24 11.4 16.3 0.28 11.2 16.3 1.1 1 0 0 1 1 1 0 Protein trafficking PGA2 TFIIF_alpha PF05793.12 EMC87789.1 - 0.7 8.4 20.2 0.76 8.3 20.2 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) HGTP_anticodon2 PF12745.7 EMC87789.1 - 1.8 8.0 9.7 2.1 7.8 9.7 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs CDC45 PF02724.14 EMC87789.1 - 5.6 5.1 14.8 6.1 5.0 14.8 1.0 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 EMC87789.1 - 5.8 6.7 13.6 6.7 6.4 13.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Vfa1 PF08432.10 EMC87789.1 - 10 6.4 13.7 12 6.2 13.7 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 TraB PF01963.17 EMC87790.1 - 1.3e-37 130.1 0.0 1.5e-37 129.9 0.0 1.0 1 0 0 1 1 1 1 TraB family Ras PF00071.22 EMC87791.1 - 6.6e-18 64.8 0.0 6.9e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 Ras family RsgA_GTPase PF03193.16 EMC87791.1 - 0.002 18.1 0.0 0.003 17.5 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase TPP_enzyme_M PF00205.22 EMC87791.1 - 0.0047 16.7 0.0 0.0065 16.2 0.0 1.2 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain MMR_HSR1_Xtn PF16897.5 EMC87791.1 - 0.0096 15.9 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.18 EMC87791.1 - 0.015 14.8 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 Ferrous iron transport protein B Importin_rep_4 PF18808.1 EMC87792.1 - 1.9e-27 95.4 1.7 1.9e-27 95.4 1.7 3.5 2 0 0 2 2 2 1 Importin repeat HEAT_EZ PF13513.6 EMC87792.1 - 8.7e-19 67.6 3.9 2e-08 34.6 0.0 7.6 9 1 1 10 10 7 2 HEAT-like repeat HEAT PF02985.22 EMC87792.1 - 1e-17 62.7 7.2 0.00011 22.2 0.0 8.4 9 0 0 9 9 8 3 HEAT repeat HEAT_2 PF13646.6 EMC87792.1 - 1.7e-17 63.6 0.6 1.5e-08 34.9 0.0 6.7 4 2 2 6 6 6 2 HEAT repeats Vac14_Fab1_bd PF12755.7 EMC87792.1 - 4.5e-12 46.4 6.9 2.9e-05 24.6 0.0 8.4 6 2 3 9 9 9 1 Vacuolar 14 Fab1-binding region Importin_rep_6 PF18829.1 EMC87792.1 - 4.8e-12 46.0 1.6 3e-10 40.2 0.1 3.9 4 0 0 4 4 4 1 Importin repeat 6 Cnd1 PF12717.7 EMC87792.1 - 7.1e-09 35.9 4.1 0.00041 20.4 0.1 4.6 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.8 EMC87792.1 - 1.9e-06 27.9 4.6 1.7 8.5 0.1 7.9 6 2 4 10 10 10 1 Domain of unknown function (DUF3385) IBN_N PF03810.19 EMC87792.1 - 0.00017 21.4 3.1 0.00051 19.9 0.1 3.4 4 0 0 4 4 4 1 Importin-beta N-terminal domain Importin_rep_5 PF18816.1 EMC87792.1 - 0.0013 19.0 0.1 0.053 13.8 0.0 2.9 2 0 0 2 2 2 1 Importin repeat Arm PF00514.23 EMC87792.1 - 0.0014 18.6 3.9 8.2 6.6 0.0 5.7 6 0 0 6 6 5 1 Armadillo/beta-catenin-like repeat PBP1_TM PF14812.6 EMC87792.1 - 0.025 14.9 0.2 0.025 14.9 0.2 2.2 2 0 0 2 2 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RTP1_C1 PF10363.9 EMC87792.1 - 0.033 14.4 2.4 1.1 9.5 0.0 4.4 5 1 1 6 6 5 0 Required for nuclear transport of RNA pol II C-terminus 1 AbiJ_NTD5 PF18865.1 EMC87792.1 - 0.1 12.4 0.1 0.96 9.3 0.4 2.6 2 0 0 2 2 1 0 AbiJ N-terminal domain 5 Sec7_N PF12783.7 EMC87792.1 - 0.12 12.3 3.7 6.5 6.6 0.5 4.8 5 1 1 6 6 6 0 Guanine nucleotide exchange factor in Golgi transport N-terminal CLASP_N PF12348.8 EMC87792.1 - 0.57 9.7 6.6 8.2 5.9 0.0 5.4 6 2 1 7 7 7 0 CLASP N terminal AAA_30 PF13604.6 EMC87792.1 - 0.57 9.9 3.1 8.2 6.1 0.0 3.4 3 1 0 3 3 3 0 AAA domain HEAT_PBS PF03130.16 EMC87792.1 - 2.6 9.0 5.3 34 5.5 0.0 4.7 4 1 0 4 4 3 0 PBS lyase HEAT-like repeat RhoGEF PF00621.20 EMC87794.1 - 3.1e-31 109.0 1.2 6.9e-31 107.9 1.2 1.7 1 0 0 1 1 1 1 RhoGEF domain FERM_C PF09380.10 EMC87794.1 - 1.8e-25 89.1 0.2 5e-25 87.7 0.2 1.8 1 0 0 1 1 1 1 FERM C-terminal PH-like domain PH PF00169.29 EMC87794.1 - 7.8e-24 84.2 0.4 1.6e-13 51.0 0.6 2.8 2 0 0 2 2 2 2 PH domain FA PF08736.11 EMC87794.1 - 5.6e-16 58.4 3.0 1.9e-15 56.6 3.0 2.0 1 0 0 1 1 1 1 FERM adjacent (FA) FERM_M PF00373.18 EMC87794.1 - 3.6e-11 43.5 0.3 3.6e-11 43.5 0.3 2.2 3 0 0 3 3 3 1 FERM central domain FERM_N PF09379.10 EMC87794.1 - 1.3e-08 34.6 0.0 3.3e-08 33.4 0.0 1.8 1 0 0 1 1 1 1 FERM N-terminal domain IQ_SEC7_PH PF16453.5 EMC87794.1 - 2.4e-06 27.6 0.0 8.2e-06 25.8 0.0 1.9 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 EMC87794.1 - 8.2e-05 22.5 3.6 0.18 11.6 0.0 3.3 2 1 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.6 EMC87794.1 - 0.34 11.3 8.4 0.55 10.7 1.3 4.4 4 1 0 4 4 4 0 Pleckstrin homology domain Pkinase PF00069.25 EMC87795.1 - 1e-51 175.9 0.0 1.3e-51 175.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87795.1 - 4.2e-39 134.4 0.0 5.6e-39 134.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC87795.1 - 1.1e-05 24.4 0.0 2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase DUF1241 PF06840.11 EMC87795.1 - 0.00013 21.6 0.0 0.00034 20.3 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Kinase-like PF14531.6 EMC87795.1 - 0.024 14.0 0.0 0.053 12.8 0.0 1.5 1 1 0 1 1 1 0 Kinase-like Kdo PF06293.14 EMC87795.1 - 0.075 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PTR2 PF00854.21 EMC87796.1 - 4.6e-138 460.4 10.0 2.7e-128 428.2 6.9 2.2 2 0 0 2 2 2 2 POT family MFS_2 PF13347.6 EMC87796.1 - 5.7e-07 28.4 9.1 0.0097 14.5 0.0 3.4 2 1 1 3 3 3 3 MFS/sugar transport protein AlgF PF11182.8 EMC87796.1 - 0.012 15.4 0.2 0.038 13.8 0.0 1.8 2 0 0 2 2 2 0 Alginate O-acetyl transferase AlgF Phage_holin_3_6 PF07332.11 EMC87796.1 - 0.039 14.0 0.8 0.039 14.0 0.8 3.3 4 0 0 4 4 4 0 Putative Actinobacterial Holin-X, holin superfamily III Phage_Gp23 PF10669.9 EMC87796.1 - 0.077 13.3 0.1 0.82 10.0 0.0 2.3 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) AcrZ PF10766.9 EMC87796.1 - 1.4 8.6 5.3 11 5.7 5.3 2.6 1 0 0 1 1 1 0 Multidrug efflux pump-associated protein AcrZ PGG PF13962.6 EMC87796.1 - 4.4 7.1 9.5 11 5.9 2.7 3.5 3 0 0 3 3 3 0 Domain of unknown function DUF2207 PF09972.9 EMC87796.1 - 6 5.5 7.0 15 4.2 0.1 2.8 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) DHR-2 PF06920.13 EMC87797.1 - 1.3e-210 700.6 7.4 1.3e-210 700.6 7.4 2.1 2 0 0 2 2 2 1 Dock homology region 2 DOCK-C2 PF14429.6 EMC87797.1 - 7.2e-58 195.6 0.2 2.3e-57 194.0 0.2 2.0 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.8 EMC87797.1 - 3.9e-42 143.2 0.6 1.3e-41 141.5 0.6 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) PH PF00169.29 EMC87797.1 - 4.1e-14 53.0 0.3 1.5e-13 51.2 0.3 2.1 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 EMC87797.1 - 3.4e-05 24.2 0.0 0.00018 21.8 0.0 2.3 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 EMC87797.1 - 0.027 14.7 0.1 0.081 13.2 0.1 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain UBA PF00627.31 EMC87798.1 - 4.1e-12 45.7 0.6 7.4e-12 44.9 0.6 1.5 1 0 0 1 1 1 1 UBA/TS-N domain 7tm_1 PF00001.21 EMC87799.1 - 2.2e-48 164.9 12.8 2.8e-48 164.6 12.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.13 EMC87799.1 - 0.1 11.7 8.6 0.22 10.6 2.3 2.2 2 0 0 2 2 2 0 Taste receptor protein (TAS2R) OapA_N PF08525.11 EMC87799.1 - 0.24 11.4 3.4 0.85 9.6 3.4 2.0 1 0 0 1 1 1 0 Opacity-associated protein A N-terminal motif Chordopox_G3 PF06129.12 EMC87799.1 - 8.1 7.2 7.1 0.57 10.9 0.8 2.4 3 0 0 3 3 3 0 Chordopoxvirus G3 protein HpcH_HpaI PF03328.14 EMC87800.1 - 8e-48 162.5 0.0 1e-47 162.1 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 EMC87800.1 - 2.5e-10 40.1 0.1 5e-06 25.9 0.0 2.2 1 1 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold zf-C2H2 PF00096.26 EMC87801.1 - 1.2e-13 50.7 19.7 1.7e-06 28.1 3.1 3.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC87801.1 - 9.2e-09 35.3 26.5 1.3e-05 25.3 2.2 4.0 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC87801.1 - 7.4e-06 26.4 17.1 0.0045 17.7 1.7 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC87801.1 - 0.0062 16.5 4.5 0.44 10.6 0.1 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 EMC87801.1 - 0.051 14.0 1.1 0.051 14.0 1.1 4.0 3 1 0 3 3 3 0 Zinc-finger of C2H2 type CHORD PF04968.12 EMC87801.1 - 0.36 11.6 10.7 7.2 7.4 0.1 3.0 1 1 2 3 3 3 0 CHORD zf-C2H2_jaz PF12171.8 EMC87801.1 - 2.6 8.4 18.2 0.75 10.2 1.3 3.9 4 1 0 4 4 4 0 Zinc-finger double-stranded RNA-binding p450 PF00067.22 EMC87802.1 - 4.3e-17 62.0 0.1 4.6e-17 61.9 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 zf-RING_UBOX PF13445.6 EMC87803.1 - 5.2e-09 36.0 5.5 5.2e-09 36.0 5.5 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EMC87803.1 - 2e-08 34.4 10.1 4.7e-08 33.2 10.1 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EMC87803.1 - 4.4e-08 32.9 9.4 8.3e-08 32.1 9.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EMC87803.1 - 9.4e-05 22.2 10.3 0.00017 21.4 10.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 EMC87803.1 - 0.0025 17.9 4.4 0.0025 17.9 4.4 1.7 2 0 0 2 2 2 1 FYVE zinc finger zf-RING_11 PF17123.5 EMC87803.1 - 0.0072 16.0 7.2 0.0072 16.0 7.2 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EMC87803.1 - 0.0077 16.1 13.8 0.061 13.2 13.8 2.3 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC87803.1 - 0.0078 16.1 13.6 0.37 10.7 13.8 2.8 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 GAGA PF09237.11 EMC87803.1 - 0.045 13.5 4.8 0.62 9.9 0.3 2.5 1 1 1 2 2 2 0 GAGA factor FYVE_2 PF02318.16 EMC87803.1 - 0.12 12.6 5.2 0.067 13.4 2.5 1.8 2 0 0 2 2 2 0 FYVE-type zinc finger zf-RING_4 PF14570.6 EMC87803.1 - 0.41 10.5 7.8 0.85 9.5 7.8 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 EMC87803.1 - 1 9.6 15.5 0.71 10.1 11.9 2.6 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING PIRT PF15099.6 EMC87804.1 - 8.4e-68 225.9 2.3 9.5e-68 225.8 2.3 1.0 1 0 0 1 1 1 1 Phosphoinositide-interacting protein family TMEM100 PF16311.5 EMC87804.1 - 0.00038 20.1 0.1 0.00043 19.9 0.1 1.2 1 0 0 1 1 1 1 Transmembrane protein 100 7TM_GPCR_Srz PF10325.9 EMC87804.1 - 0.019 14.3 1.3 0.022 14.1 1.3 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srz SdpI PF13630.6 EMC87804.1 - 0.028 14.5 3.1 0.21 11.7 3.2 2.0 1 1 0 1 1 1 0 SdpI/YhfL protein family DUF872 PF05915.12 EMC87804.1 - 0.06 13.5 0.0 0.078 13.2 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) Phage_holin_3_6 PF07332.11 EMC87804.1 - 0.074 13.1 0.3 0.1 12.7 0.3 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III CcmD PF04995.14 EMC87804.1 - 0.7 10.0 2.2 7.5 6.7 0.2 2.4 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) DUF3955 PF13127.6 EMC87804.1 - 1.4 8.8 6.8 1.7 8.5 2.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3955) Neurensin PF14927.6 EMC87804.1 - 1.4 8.6 3.8 4.7 6.9 0.1 2.1 1 1 1 2 2 2 0 Neurensin Shisa PF13908.6 EMC87805.1 - 4.7e-24 85.7 0.5 6.3e-24 85.3 0.5 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator DUF3136 PF11334.8 EMC87805.1 - 0.013 15.3 0.7 0.023 14.5 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3136) PBP PF01161.20 EMC87808.1 - 6.7e-11 42.6 0.2 8.9e-11 42.2 0.2 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein MHC_II_alpha PF00993.20 EMC87809.1 - 4.4e-29 100.0 0.2 6e-29 99.6 0.2 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set PF07654.15 EMC87809.1 - 4.7e-25 87.8 0.0 6.5e-25 87.3 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin C1-set domain C2-set_2 PF08205.12 EMC87809.1 - 0.00016 21.6 0.0 0.00043 20.3 0.0 1.7 1 1 1 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 EMC87809.1 - 0.00016 22.2 0.0 0.00024 21.7 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain MHC_II_beta PF00969.19 EMC87810.1 - 4e-35 119.8 0.1 5.2e-35 119.4 0.1 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain MHC_I PF00129.18 EMC87810.1 - 0.0087 15.6 0.1 0.011 15.4 0.1 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 7tm_1 PF00001.21 EMC87811.1 - 6.2e-17 61.8 2.6 7.9e-17 61.5 2.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC87811.1 - 2.5e-15 57.0 2.5 2.9e-15 56.8 2.5 1.0 1 0 0 1 1 1 1 Olfactory receptor Se-cys_synth_N PF12390.8 EMC87812.1 - 7.3e-05 22.9 13.6 0.73 10.1 0.2 4.2 4 0 0 4 4 4 3 Selenocysteine synthase N terminal XdhC_CoxI PF02625.16 EMC87812.1 - 0.68 10.2 3.8 74 3.6 1.8 3.6 2 1 0 2 2 2 0 XdhC and CoxI family MOZART1 PF12554.8 EMC87812.1 - 1.4 8.7 5.9 56 3.6 0.0 4.0 4 0 0 4 4 4 0 Mitotic-spindle organizing gamma-tubulin ring associated ART PF01129.18 EMC87813.1 - 1.1e-30 106.6 0.3 1.2e-30 106.5 0.3 1.0 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 EMC87813.1 - 0.012 15.0 0.0 0.014 14.7 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosyltransferase exoenzyme zf-RING_2 PF13639.6 EMC87814.1 - 1.7e-06 28.2 6.0 3e-06 27.4 6.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EMC87814.1 - 8.8e-05 22.7 7.5 0.00018 21.7 7.5 1.5 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EMC87814.1 - 0.00057 19.7 5.8 0.0013 18.5 5.8 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC87814.1 - 0.0015 18.4 6.2 0.0026 17.7 6.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EMC87814.1 - 0.0034 17.2 7.6 0.022 14.6 7.6 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EMC87814.1 - 0.0075 16.0 3.4 0.024 14.4 3.4 1.9 1 1 0 1 1 1 1 RING-like zinc finger Prok-RING_4 PF14447.6 EMC87814.1 - 0.0082 16.0 5.0 0.016 15.1 4.9 1.5 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EMC87814.1 - 0.009 16.0 5.1 0.027 14.5 5.1 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger DZR PF12773.7 EMC87814.1 - 0.0091 16.0 0.2 0.02 14.9 0.2 1.5 1 1 0 1 1 1 1 Double zinc ribbon zf-Di19 PF05605.12 EMC87814.1 - 0.02 15.2 1.9 0.27 11.6 0.1 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-ribbon_3 PF13248.6 EMC87814.1 - 0.047 13.1 1.6 2.6 7.6 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Cys_rich_CPXG PF14255.6 EMC87814.1 - 0.068 13.1 1.4 4.2 7.4 0.0 2.3 2 0 0 2 2 2 0 Cysteine-rich CPXCG zf-RING_UBOX PF13445.6 EMC87814.1 - 0.071 13.1 3.8 0.36 10.9 4.0 2.0 1 1 1 2 2 2 0 RING-type zinc-finger FANCL_C PF11793.8 EMC87814.1 - 0.077 13.2 7.8 1.8 8.8 7.8 2.5 1 1 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 EMC87814.1 - 0.13 11.9 7.5 0.48 10.1 7.7 1.9 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-UDP PF14569.6 EMC87814.1 - 0.26 11.5 5.5 0.59 10.3 5.5 1.6 1 1 0 1 1 1 0 Zinc-binding RING-finger Phage_holin_3_6 PF07332.11 EMC87814.1 - 0.36 10.9 5.1 0.59 10.2 0.3 2.3 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III zf-C3HC4_3 PF13920.6 EMC87814.1 - 0.51 10.2 7.8 3.2 7.7 7.7 2.1 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) XRCC1_N PF01834.16 EMC87815.1 - 4.1e-14 52.8 0.0 4.4e-14 52.7 0.0 1.0 1 0 0 1 1 1 1 XRCC1 N terminal domain DUF3584 PF12128.8 EMC87816.1 - 0.076 10.5 42.9 0.1 10.1 42.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ATG16 PF08614.11 EMC87816.1 - 1.4 9.1 53.6 8.4 6.6 15.6 4.2 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) Fez1 PF06818.15 EMC87816.1 - 2.2 8.7 42.3 0.052 14.0 19.4 2.7 1 1 1 2 2 2 0 Fez1 CENP-F_leu_zip PF10473.9 EMC87816.1 - 3.9 7.5 56.2 2.8 8.0 13.0 4.5 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CENP-H PF05837.12 EMC87816.1 - 6.2 7.3 39.2 0.5 10.8 6.7 3.6 1 1 1 3 3 3 0 Centromere protein H (CENP-H) MDMPI_N PF11716.8 EMC87816.1 - 7.8 7.2 6.5 27 5.4 0.0 2.8 3 0 0 3 3 3 0 Mycothiol maleylpyruvate isomerase N-terminal domain LAMTOR PF15454.6 EMC87817.1 - 2.2e-21 76.2 0.2 3.8e-21 75.5 0.2 1.4 1 0 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator ANAPC15 PF15243.6 EMC87819.1 - 1.1e-39 134.8 15.2 1.1e-39 134.8 15.2 1.8 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 15 RNA_pol_3_Rpc31 PF11705.8 EMC87819.1 - 0.0013 19.0 14.4 0.0017 18.7 14.4 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 DUF4746 PF15928.5 EMC87819.1 - 0.029 13.8 8.2 0.033 13.6 8.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RNA_pol_Rpc4 PF05132.14 EMC87819.1 - 0.14 12.6 1.8 0.18 12.2 1.8 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF2457 PF10446.9 EMC87819.1 - 0.42 9.7 26.8 0.48 9.5 26.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CPSF100_C PF13299.6 EMC87819.1 - 0.84 9.8 4.2 0.95 9.6 4.2 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal V_ATPase_I PF01496.19 EMC87819.1 - 0.94 7.3 2.6 1 7.2 2.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Astro_capsid_p PF12226.8 EMC87819.1 - 1.6 7.8 16.7 1.8 7.6 16.7 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein TFB6 PF17110.5 EMC87819.1 - 2.8 7.7 9.0 3.7 7.2 9.0 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Presenilin PF01080.17 EMC87819.1 - 3.6 6.3 4.4 3.9 6.1 4.4 1.0 1 0 0 1 1 1 0 Presenilin Nop14 PF04147.12 EMC87819.1 - 5.2 5.1 23.1 6.1 4.9 23.1 1.0 1 0 0 1 1 1 0 Nop14-like family Pox_Ag35 PF03286.14 EMC87819.1 - 6.5 6.5 13.2 8.1 6.2 13.2 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein zf-H2C2_2 PF13465.6 EMC87820.1 - 2.3e-71 233.2 113.4 1e-08 35.2 3.4 14.5 14 0 0 14 14 14 11 Zinc-finger double domain zf-C2H2 PF00096.26 EMC87820.1 - 3.9e-47 156.1 135.8 8.6e-06 25.9 2.5 13.9 15 0 0 15 15 13 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC87820.1 - 6.1e-29 98.2 120.8 0.0019 18.9 1.0 14.1 14 0 0 14 14 14 11 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC87820.1 - 4.5e-10 39.6 62.5 0.025 14.9 0.1 12.0 13 0 0 13 13 12 6 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 EMC87820.1 - 4e-05 24.0 68.2 0.44 11.0 0.2 10.8 4 3 6 11 11 11 4 C2HE / C2H2 / C2HC zinc-binding finger FYDLN_acid PF09538.10 EMC87820.1 - 0.0011 19.6 27.8 46 4.7 0.1 10.1 3 3 7 11 11 10 0 Protein of unknown function (FYDLN_acid) BHD_1 PF10403.9 EMC87820.1 - 0.0065 16.3 1.9 11 6.0 0.0 4.2 4 0 0 4 4 4 0 Rad4 beta-hairpin domain 1 BDHCT_assoc PF16204.5 EMC87820.1 - 0.0086 15.8 5.6 0.77 9.4 0.1 3.9 3 1 1 5 5 5 1 BDHCT-box associated domain on Bloom syndrome protein zf-LYAR PF08790.11 EMC87820.1 - 0.009 15.9 0.8 0.009 15.9 0.8 11.9 12 0 0 12 12 12 4 LYAR-type C2HC zinc finger zf_UBZ PF18439.1 EMC87820.1 - 0.0092 15.6 53.6 1 9.0 0.5 10.9 11 0 0 11 11 11 4 Ubiquitin-Binding Zinc Finger TonB_N PF16031.5 EMC87820.1 - 0.019 15.5 6.3 0.032 14.8 6.3 1.2 1 0 0 1 1 1 0 TonB polyproline region DUF3268 PF11672.8 EMC87820.1 - 0.027 14.8 32.3 0.31 11.4 1.4 6.3 4 2 1 6 6 6 0 zinc-finger-containing domain zf-C2H2_6 PF13912.6 EMC87820.1 - 0.029 14.4 0.1 0.029 14.4 0.1 13.1 13 1 0 13 13 11 0 C2H2-type zinc finger LIM PF00412.22 EMC87820.1 - 0.13 12.5 70.2 0.19 11.9 3.4 10.2 2 2 9 11 11 11 0 LIM domain zf-AN1 PF01428.16 EMC87820.1 - 0.34 11.1 74.6 0.32 11.2 4.5 11.2 10 1 1 11 11 11 0 AN1-like Zinc finger Zn-ribbon_8 PF09723.10 EMC87820.1 - 1.1 9.4 55.8 0.16 12.1 1.3 8.6 3 3 10 13 13 13 0 Zinc ribbon domain zf-RING_7 PF02591.15 EMC87820.1 - 6.6 7.0 27.0 31 4.9 0.1 8.7 9 0 0 9 9 8 0 C4-type zinc ribbon domain zinc_ribbon_15 PF17032.5 EMC87820.1 - 7.9 7.3 46.8 1.8 9.3 0.7 6.8 2 2 7 9 9 9 0 zinc-ribbon family zf-H2C2_2 PF13465.6 EMC87822.1 - 1.2e-90 294.2 88.7 1.1e-08 35.0 2.0 14.3 14 0 0 14 14 14 12 Zinc-finger double domain zf-C2H2 PF00096.26 EMC87822.1 - 8.1e-63 205.5 117.0 2.5e-06 27.6 0.8 13.8 13 1 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC87822.1 - 4.6e-41 135.9 104.5 0.0013 19.4 1.4 13.4 13 0 0 13 13 13 13 C2H2-type zinc finger KRAB PF01352.27 EMC87822.1 - 1.7e-21 75.5 0.2 3.9e-21 74.4 0.2 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.8 EMC87822.1 - 4.6e-13 49.1 49.3 0.42 11.0 0.2 12.8 13 0 0 13 13 13 5 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.11 EMC87822.1 - 5e-12 45.5 76.1 0.02 14.8 0.9 12.4 13 0 0 13 13 13 7 LYAR-type C2HC zinc finger zf-met PF12874.7 EMC87822.1 - 4.2e-10 39.7 68.7 0.39 11.2 0.3 12.4 12 0 0 12 12 12 6 Zinc-finger of C2H2 type zf_UBZ PF18439.1 EMC87822.1 - 5.9e-07 29.0 52.6 1 9.0 0.3 11.8 13 0 0 13 13 12 5 Ubiquitin-Binding Zinc Finger ADK_lid PF05191.14 EMC87822.1 - 5.7e-06 26.2 39.4 0.38 10.8 0.8 8.3 5 3 0 5 5 5 3 Adenylate kinase, active site lid zf-C2H2_6 PF13912.6 EMC87822.1 - 6.7e-06 26.0 88.3 0.04 13.9 0.2 13.5 13 1 0 13 13 13 5 C2H2-type zinc finger zf-trcl PF13451.6 EMC87822.1 - 1.7e-05 24.6 58.3 0.53 10.2 0.4 11.8 13 0 0 13 13 13 4 Probable zinc-ribbon domain LIM PF00412.22 EMC87822.1 - 2.1e-05 24.6 63.1 1.7 8.9 2.5 11.3 2 1 11 13 13 12 8 LIM domain zf-AN1 PF01428.16 EMC87822.1 - 2.4e-05 24.4 67.6 6.4 7.0 0.3 13.2 11 2 2 13 13 13 1 AN1-like Zinc finger DUF3268 PF11672.8 EMC87822.1 - 0.00039 20.7 22.8 5.6 7.3 0.1 6.4 5 2 2 7 7 7 2 zinc-finger-containing domain Zn-ribbon_8 PF09723.10 EMC87822.1 - 0.00042 20.4 56.6 0.43 10.7 0.7 9.3 2 2 8 11 11 11 5 Zinc ribbon domain YhfH PF14149.6 EMC87822.1 - 0.013 15.4 32.3 9.4 6.3 0.2 9.4 10 0 0 10 10 9 0 YhfH-like protein FYDLN_acid PF09538.10 EMC87822.1 - 0.016 15.9 29.4 0.75 10.5 0.2 9.5 1 1 10 11 11 11 0 Protein of unknown function (FYDLN_acid) BDHCT_assoc PF16204.5 EMC87822.1 - 0.025 14.3 8.4 6.3 6.4 0.1 3.8 1 1 3 4 4 4 0 BDHCT-box associated domain on Bloom syndrome protein zf-C2HE PF16278.5 EMC87822.1 - 0.027 14.9 75.5 2.9 8.4 0.6 12.8 1 1 9 10 10 10 0 C2HE / C2H2 / C2HC zinc-binding finger BHD_1 PF10403.9 EMC87822.1 - 0.078 12.8 3.2 43 4.0 0.0 4.4 5 1 0 5 5 4 0 Rad4 beta-hairpin domain 1 zf_C2H2_ZHX PF18387.1 EMC87822.1 - 0.097 12.3 57.2 0.38 10.4 2.7 10.6 1 1 8 10 10 10 0 Zinc-fingers and homeoboxes C2H2 finger domain zinc_ribbon_15 PF17032.5 EMC87822.1 - 0.11 13.3 42.0 0.52 11.1 0.3 7.1 1 1 7 8 8 7 0 zinc-ribbon family BolA PF01722.18 EMC87822.1 - 0.28 11.5 27.3 4.7 7.6 1.5 6.1 4 2 2 6 6 6 0 BolA-like protein RYDR_ITPR PF01365.21 EMC87822.1 - 0.33 10.4 5.5 6.4 6.1 0.1 4.0 2 1 2 4 4 4 0 RIH domain CpXC PF14353.6 EMC87822.1 - 0.33 11.0 47.9 1.3 9.1 1.1 10.4 1 1 7 9 9 9 0 CpXC protein C1_4 PF07975.12 EMC87822.1 - 3.5 8.0 58.9 0.64 10.3 1.2 7.9 3 2 6 10 10 10 0 TFIIH C1-like domain zf-Di19 PF05605.12 EMC87822.1 - 5.3 7.4 66.1 0.45 10.9 0.7 8.3 4 2 4 8 8 8 0 Drought induced 19 protein (Di19), zinc-binding MDM1 PF15501.6 EMC87823.1 - 0.012 14.8 25.4 0.014 14.6 25.4 1.1 1 0 0 1 1 1 0 Nuclear protein MDM1 FAM60A PF15396.6 EMC87823.1 - 0.038 14.0 20.0 0.053 13.5 20.0 1.2 1 0 0 1 1 1 0 Protein Family FAM60A MCM_bind PF09739.9 EMC87823.1 - 0.041 12.3 16.1 0.061 11.8 16.1 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Presenilin PF01080.17 EMC87823.1 - 1.3 7.7 23.3 1.6 7.4 23.3 1.0 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 EMC87823.1 - 2.4 7.0 8.9 3.1 6.7 8.9 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) AF-4 PF05110.13 EMC87823.1 - 3.4 5.6 27.0 3.7 5.5 27.0 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein CAF-1_p150 PF11600.8 EMC87823.1 - 6.3 6.5 63.5 8 6.1 63.5 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal AAA_11 PF13086.6 EMC87823.1 - 7.6 6.2 20.1 11 5.8 20.1 1.2 1 0 0 1 1 1 0 AAA domain SOBP PF15279.6 EMC87823.1 - 8.7 6.9 11.8 9.9 6.7 11.8 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein zf-H2C2_5 PF13909.6 EMC87824.1 - 3.8e-16 58.5 28.3 1.2e-07 31.3 1.8 28.5 30 0 0 30 30 30 16 C2H2-type zinc-finger domain zf_C2H2_ZHX PF18387.1 EMC87824.1 - 5.9e-11 41.8 152.8 0.0083 15.7 1.4 26.9 26 2 3 29 29 29 15 Zinc-fingers and homeoboxes C2H2 finger domain zf-H2C2_2 PF13465.6 EMC87824.1 - 0.0075 16.7 6.6 0.0075 16.7 6.6 28.8 34 0 0 34 34 34 11 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC87824.1 - 0.012 16.3 0.2 0.012 16.3 0.2 34.7 35 0 0 35 35 35 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC87824.1 - 0.055 13.9 0.1 0.055 13.9 0.1 32.5 36 0 0 36 36 36 0 Zinc finger, C2H2 type DUF647 PF04884.14 EMC87826.1 - 8e-25 87.9 0.1 9.9e-25 87.6 0.1 1.0 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis 7tm_1 PF00001.21 EMC87827.1 - 4.2e-56 190.2 18.1 7e-56 189.5 18.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC87827.1 - 1.4e-06 28.2 21.6 2.1e-06 27.6 20.0 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 EMC87827.1 - 1.8e-05 24.3 25.4 0.0066 15.9 6.2 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC87827.1 - 0.00017 21.4 17.3 0.00031 20.6 17.3 1.4 1 1 0 1 1 1 1 Olfactory receptor CBP_BcsG PF11658.8 EMC87827.1 - 0.15 10.4 5.1 0.012 14.0 0.5 1.5 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsG zf-LITAF-like PF10601.9 EMC87827.1 - 1.2 9.4 4.9 20 5.6 0.5 3.3 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain Serum_albumin PF00273.20 EMC87828.1 - 1.6e-82 275.6 19.1 1.9e-46 158.1 5.3 3.0 2 1 1 3 3 3 3 Serum albumin family VitD-bind_III PF09164.10 EMC87828.1 - 1.5e-16 60.1 24.1 2.9e-13 49.6 0.2 5.4 5 2 1 6 6 6 4 Vitamin D binding protein, domain III dNK PF01712.19 EMC87830.1 - 4.4e-64 216.1 0.3 5.3e-64 215.8 0.3 1.0 1 0 0 1 1 1 1 Deoxynucleoside kinase Thymidylate_kin PF02223.17 EMC87830.1 - 0.0018 17.9 0.1 0.0064 16.2 0.1 2.0 1 1 0 1 1 1 1 Thymidylate kinase AAA_18 PF13238.6 EMC87830.1 - 0.012 16.2 0.0 0.065 13.8 0.0 2.2 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EMC87830.1 - 0.016 15.5 0.1 0.037 14.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EMC87830.1 - 0.16 12.4 0.0 0.4 11.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain Mob1_phocein PF03637.17 EMC87831.1 - 2.9e-84 281.2 0.1 3.5e-84 281.0 0.1 1.1 1 0 0 1 1 1 1 Mob1/phocein family RRM_1 PF00076.22 EMC87832.1 - 2.4e-18 65.7 0.0 1.1e-07 31.6 0.0 3.4 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EMC87832.1 - 0.00022 21.2 0.0 0.61 10.2 0.0 2.5 2 0 0 2 2 2 2 RNA binding motif DPRP PF04244.13 EMC87832.1 - 0.0016 18.4 0.1 0.0057 16.5 0.0 1.9 2 0 0 2 2 2 1 Deoxyribodipyrimidine photo-lyase-related protein PSCyt1 PF07635.11 EMC87832.1 - 0.034 14.7 0.2 0.084 13.5 0.2 1.7 1 0 0 1 1 1 0 Planctomycete cytochrome C DUF1491 PF07372.12 EMC87832.1 - 0.26 11.6 0.9 1.5 9.2 0.5 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1491) RUN PF02759.19 EMC87833.1 - 2.3e-32 111.8 4.0 4.2e-32 110.9 0.0 2.7 2 1 0 2 2 2 1 RUN domain Trimer_CC PF08954.11 EMC87833.1 - 0.0028 17.2 6.4 0.11 12.1 0.0 3.2 3 0 0 3 3 3 2 Trimerisation motif ATG16 PF08614.11 EMC87833.1 - 0.19 11.9 27.8 0.36 11.0 27.8 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) KASH_CCD PF14662.6 EMC87833.1 - 0.23 11.3 37.0 0.6 9.9 23.7 2.7 1 1 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH DUF1664 PF07889.12 EMC87833.1 - 1.7 8.7 25.0 0.13 12.3 2.9 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DUF5595 PF18077.1 EMC87833.1 - 2.9 8.0 18.2 0.59 10.3 0.9 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF5595) Sas10 PF09368.10 EMC87834.1 - 4.9e-26 91.0 12.6 4.9e-26 91.0 12.6 2.3 2 0 0 2 2 2 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 EMC87834.1 - 4.2e-16 59.3 2.8 6.7e-16 58.7 0.1 2.4 3 0 0 3 3 3 1 Sas10/Utp3/C1D family DnaGprimase_HBD PF16730.5 EMC87834.1 - 0.13 12.4 0.1 0.13 12.4 0.1 2.0 2 0 0 2 2 2 0 DnaG-primase C-terminal, helicase-binding domain RST PF12174.8 EMC87834.1 - 9.1 6.3 9.6 6.1 6.8 0.3 2.7 2 0 0 2 2 2 0 RCD1-SRO-TAF4 (RST) plant domain PRP1_N PF06424.12 EMC87834.1 - 9.8 6.6 14.4 2.7 8.4 5.2 2.5 1 1 1 2 2 2 0 PRP1 splicing factor, N-terminal Ig_J_chain PF15097.6 EMC87835.1 - 1.2e-66 222.7 7.6 1.4e-66 222.4 7.6 1.0 1 0 0 1 1 1 1 Immunoglobulin J chain RTP1_C1 PF10363.9 EMC87835.1 - 0.12 12.6 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 SDA1 PF05285.12 EMC87836.1 - 8.6e-64 216.1 49.9 1e-29 104.1 21.3 4.1 2 1 2 4 4 4 4 SDA1 NUC130_3NT PF08158.12 EMC87836.1 - 8.4e-25 86.8 1.5 8.4e-25 86.8 1.5 3.4 4 0 0 4 4 4 1 NUC130/3NT domain Ribosomal_L22 PF00237.19 EMC87836.1 - 0.022 15.0 2.4 0.032 14.5 0.5 2.3 2 0 0 2 2 2 0 Ribosomal protein L22p/L17e DUF5616 PF18481.1 EMC87836.1 - 0.2 12.0 1.6 28 5.0 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF5616) CBAH PF02275.18 EMC87837.1 - 8.4e-08 32.2 0.1 9.6e-05 22.2 0.0 2.3 2 1 0 2 2 2 2 Linear amide C-N hydrolases, choloylglycine hydrolase family Metallophos PF00149.28 EMC87838.1 - 4e-26 92.8 0.0 1.8e-20 74.3 0.0 2.4 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase EF-hand_1 PF00036.32 EMC87838.1 - 3.4e-18 63.8 1.1 6e-06 25.4 0.1 3.7 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EMC87838.1 - 9.6e-18 64.4 6.9 1.3e-10 41.5 3.0 3.0 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EMC87838.1 - 6.9e-15 53.6 2.0 0.0017 18.2 0.1 3.9 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 EMC87838.1 - 2.2e-13 49.8 2.1 1.7e-05 24.6 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EMC87838.1 - 6.8e-11 41.2 3.2 0.00048 19.5 0.0 3.6 3 0 0 3 3 3 3 EF hand PPP5 PF08321.12 EMC87838.1 - 2.7e-10 40.4 0.5 5.6e-09 36.2 0.0 3.1 2 1 1 3 3 3 1 PPP5 TPR repeat region IQ PF00612.27 EMC87838.1 - 0.00013 21.4 2.1 0.00039 20.0 2.1 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif EF-hand_4 PF12763.7 EMC87838.1 - 0.0022 17.9 4.3 0.36 10.8 0.4 3.1 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EMC87838.1 - 0.028 14.8 0.2 3.7 7.9 0.2 3.0 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EMC87838.1 - 0.042 14.2 0.0 15 6.0 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain Nup54 PF13874.6 EMC87839.1 - 5.5e-46 156.1 2.4 5.5e-46 156.1 2.4 1.9 3 0 0 3 3 3 1 Nucleoporin complex subunit 54 Nup54_C PF18437.1 EMC87839.1 - 3.1e-18 65.4 7.9 3.1e-18 65.4 7.9 2.8 2 0 0 2 2 2 1 Nup54 C-terminal interacting domain XhlA PF10779.9 EMC87839.1 - 0.071 13.3 1.2 0.26 11.5 1.2 1.9 1 0 0 1 1 1 0 Haemolysin XhlA Regulator_TrmB PF11495.8 EMC87839.1 - 0.2 10.8 1.1 22 4.1 0.1 2.9 2 1 0 3 3 3 0 Archaeal transcriptional regulator TrmB Keratin_2_head PF16208.5 EMC87839.1 - 1.2 9.3 20.7 2.3 8.4 20.7 1.5 1 0 0 1 1 1 0 Keratin type II head KRTAP PF11759.8 EMC87839.1 - 5.1 7.7 18.9 14 6.3 18.9 1.8 1 1 0 1 1 1 0 Keratin-associated matrix CBM_20 PF00686.19 EMC87840.1 - 8.1e-16 57.7 0.6 2.3e-15 56.3 0.4 1.9 2 0 0 2 2 2 1 Starch binding domain CCDC158 PF15921.5 EMC87841.1 - 6e-225 749.6 67.6 2.4e-187 625.1 49.6 2.3 1 1 1 2 2 2 2 Coiled-coil domain-containing protein 158 UPF0242 PF06785.11 EMC87841.1 - 0.00018 21.7 89.5 0.07 13.2 1.8 6.2 3 1 2 5 5 5 4 Uncharacterised protein family (UPF0242) N-terminus FlaC_arch PF05377.11 EMC87841.1 - 0.0042 17.4 1.3 0.0042 17.4 1.3 9.5 6 2 4 11 11 11 1 Flagella accessory protein C (FlaC) B2 PF11473.8 EMC87841.1 - 0.12 12.2 6.9 2.9 7.8 0.1 4.4 5 0 0 5 5 5 0 RNA binding protein B2 Golgin_A5 PF09787.9 EMC87841.1 - 1.6 8.1 97.1 0.026 14.0 21.1 5.5 2 1 2 5 5 5 0 Golgin subfamily A member 5 Shugoshin_N PF07558.11 EMC87841.1 - 4.8 7.1 11.1 16 5.4 0.4 4.7 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region Gal-bind_lectin PF00337.22 EMC87843.1 - 1.9e-27 95.4 0.0 2.3e-27 95.1 0.0 1.0 1 0 0 1 1 1 1 Galactoside-binding lectin Ank_5 PF13857.6 EMC87844.1 - 3.7e-11 43.0 0.0 2.8e-08 33.9 0.0 2.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC87844.1 - 2.1e-07 31.3 0.7 0.00016 22.2 0.2 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EMC87844.1 - 2.4e-07 30.9 0.6 3.4e-05 24.1 0.1 2.5 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 EMC87844.1 - 5.9e-07 30.0 0.0 8.2e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC87844.1 - 9.6e-05 22.5 0.1 0.018 15.5 0.1 2.6 2 0 0 2 2 2 1 Ankyrin repeat Septin PF00735.18 EMC87845.1 - 7.6e-99 330.5 1.3 7.6e-99 330.5 1.3 1.7 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EMC87845.1 - 5.8e-07 29.6 0.0 5.8e-07 29.6 0.0 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase DUF3080 PF11279.8 EMC87845.1 - 9e-05 21.8 6.6 0.00014 21.2 6.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3080) Roc PF08477.13 EMC87845.1 - 0.0004 20.6 0.0 0.0015 18.8 0.0 2.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 EMC87845.1 - 0.00047 20.6 0.1 0.0016 18.9 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EMC87845.1 - 0.00049 20.4 0.3 0.0017 18.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain Ras PF00071.22 EMC87845.1 - 0.002 17.7 0.0 0.0062 16.1 0.0 1.9 1 0 0 1 1 1 1 Ras family AAA_23 PF13476.6 EMC87845.1 - 0.0089 16.6 21.5 0.23 12.0 0.2 2.5 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EMC87845.1 - 0.012 15.4 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.27 EMC87845.1 - 0.025 14.1 9.0 0.97 8.9 0.1 3.6 3 1 0 3 3 3 0 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 EMC87845.1 - 0.03 13.8 0.0 0.063 12.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Fzo_mitofusin PF04799.13 EMC87845.1 - 0.072 12.6 8.1 0.21 11.2 8.1 1.8 1 0 0 1 1 1 0 fzo-like conserved region RsgA_GTPase PF03193.16 EMC87845.1 - 0.075 12.9 6.7 0.2 11.6 0.0 3.1 3 1 0 3 3 3 0 RsgA GTPase Dynamin_N PF00350.23 EMC87845.1 - 0.11 12.6 10.0 1.4 9.0 0.1 3.2 2 1 0 2 2 2 0 Dynamin family ABC_tran PF00005.27 EMC87845.1 - 0.25 11.8 0.1 0.25 11.8 0.1 2.6 2 2 0 2 2 1 0 ABC transporter DUF87 PF01935.17 EMC87845.1 - 0.27 11.3 7.4 2.2 8.3 0.0 2.7 3 0 0 3 3 3 0 Helicase HerA, central domain Atg14 PF10186.9 EMC87845.1 - 0.3 10.1 15.0 0.43 9.6 13.5 1.9 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Cyclin_N PF00134.23 EMC87846.1 - 6.3e-24 84.1 0.2 5.5e-23 81.1 0.1 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EMC87846.1 - 0.00037 20.6 2.8 0.0011 19.0 1.2 2.2 2 0 0 2 2 2 1 Cyclin, C-terminal domain Cyclin_N PF00134.23 EMC87847.1 - 6.5e-18 64.7 0.3 6.5e-18 64.7 0.3 1.9 1 1 1 2 2 2 1 Cyclin, N-terminal domain IL8 PF00048.20 EMC87848.1 - 7.9e-17 61.2 1.0 8.7e-17 61.0 1.0 1.0 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like IL8 PF00048.20 EMC87849.1 - 5.9e-16 58.4 0.2 6.5e-16 58.2 0.2 1.0 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like IL8 PF00048.20 EMC87850.1 - 3.1e-05 24.0 0.1 3.2e-05 24.0 0.1 1.0 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Exo_endo_phos PF03372.23 EMC87851.1 - 3.3e-22 79.2 0.0 1.9e-21 76.7 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_8 PF13855.6 EMC87851.1 - 3e-12 46.1 12.0 2.3e-11 43.3 9.2 2.6 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EMC87851.1 - 5.8e-09 36.1 17.3 2.6e-07 30.8 2.0 3.4 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EMC87851.1 - 0.0057 16.6 10.8 0.77 10.0 0.3 4.1 3 0 0 3 3 3 2 Leucine Rich repeat LRR_9 PF14580.6 EMC87851.1 - 0.011 15.3 0.6 0.022 14.3 0.6 1.4 1 0 0 1 1 1 0 Leucine-rich repeat LRR_1 PF00560.33 EMC87851.1 - 0.28 11.9 18.8 11 7.1 0.2 5.7 4 1 1 5 5 5 0 Leucine Rich Repeat Ribosomal_L1 PF00687.21 EMC87853.1 - 4.1e-18 65.9 0.4 4.7e-18 65.7 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Cornifin PF02389.15 EMC87854.1 - 1.3e-05 25.4 13.2 3.2e-05 24.1 13.2 1.7 1 1 0 1 1 1 1 Cornifin (SPRR) family MazE_antitoxin PF04014.18 EMC87854.1 - 0.13 12.2 0.2 29 4.8 0.1 3.7 2 2 1 3 3 3 0 Antidote-toxin recognition MazE, bacterial antitoxin APOBEC1 PF18769.1 EMC87856.1 - 0.56 10.5 2.9 0.73 10.1 0.3 2.2 1 1 1 2 2 2 0 APOBEC1 UCH_1 PF13423.6 EMC87857.1 - 2.6e-49 168.5 0.2 3.6e-49 168.1 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase NinE PF05322.11 EMC87857.1 - 0.24 11.3 0.8 0.57 10.1 0.8 1.6 1 0 0 1 1 1 0 NINE Protein DUF3456 PF11938.8 EMC87858.1 - 1.8e-33 116.2 0.5 2.4e-33 115.9 0.5 1.1 1 0 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP SapB_2 PF03489.17 EMC87858.1 - 0.03 14.4 0.0 0.14 12.3 0.0 2.2 2 0 0 2 2 2 0 Saposin-like type B, region 2 Citrate_synt PF00285.21 EMC87859.1 - 7.1e-84 281.9 0.0 7.9e-84 281.8 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Queuosine_synth PF02547.15 EMC87859.1 - 0.018 14.2 0.0 0.026 13.6 0.0 1.2 1 0 0 1 1 1 0 Queuosine biosynthesis protein PAS_3 PF08447.12 EMC87859.1 - 0.076 13.3 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 PAS fold Pkinase PF00069.25 EMC87860.1 - 7.5e-12 45.2 0.0 8.5e-12 45.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87860.1 - 0.00033 20.0 0.0 0.0004 19.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC87861.1 - 2.7e-53 181.0 0.1 3.2e-53 180.8 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87861.1 - 4.2e-27 95.1 0.0 4.9e-27 94.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMC87861.1 - 2.8e-06 26.8 0.3 3.7e-06 26.5 0.3 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMC87861.1 - 0.00048 20.1 0.0 0.0085 16.0 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EMC87861.1 - 0.001 18.7 0.0 0.0016 18.1 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 EMC87861.1 - 0.0098 15.2 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EMC87861.1 - 0.073 12.0 0.2 0.1 11.5 0.2 1.2 1 0 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 EMC87861.1 - 0.11 12.1 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 7tm_1 PF00001.21 EMC87863.1 - 3.5e-19 69.2 4.1 3.6e-19 69.1 4.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC87863.1 - 3.1e-16 60.0 3.6 3.5e-16 59.8 3.6 1.0 1 0 0 1 1 1 1 Olfactory receptor ATP-synt_E PF05680.12 EMC87864.1 - 5.1e-18 65.2 0.1 5.8e-18 65.0 0.1 1.1 1 0 0 1 1 1 1 ATP synthase E chain DUF1043 PF06295.12 EMC87864.1 - 0.0074 16.3 0.0 0.0094 16.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1043) DUF1211 PF06736.11 EMC87865.1 - 6e-41 138.8 6.8 2.2e-22 79.3 0.0 3.4 4 1 0 4 4 4 2 Protein of unknown function (DUF1211) Chordopox_A13L PF05961.11 EMC87865.1 - 0.85 9.9 3.6 0.53 10.5 0.3 2.3 2 0 0 2 2 2 0 Chordopoxvirus A13L protein Pkinase PF00069.25 EMC87866.1 - 1.4e-48 165.6 0.0 2.4e-48 164.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain PTEN_C2 PF10409.9 EMC87866.1 - 1.4e-30 105.8 0.0 3e-30 104.7 0.0 1.6 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein Pkinase_Tyr PF07714.17 EMC87866.1 - 1.1e-28 100.3 0.0 1.9e-28 99.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DnaJ PF00226.31 EMC87866.1 - 4.8e-06 26.6 0.0 1.2e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain Haspin_kinase PF12330.8 EMC87866.1 - 2e-05 23.7 0.0 4.1e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EMC87866.1 - 0.00034 20.0 0.0 0.015 14.6 0.0 2.5 3 0 0 3 3 3 1 Kinase-like DSPc PF00782.20 EMC87866.1 - 0.024 14.4 0.4 0.091 12.6 0.3 2.0 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC87866.1 - 0.04 13.5 0.3 0.04 13.5 0.3 2.3 2 1 1 3 3 3 0 Protein-tyrosine phosphatase Seadorna_VP7 PF07387.11 EMC87866.1 - 0.11 11.5 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 IN_DBD_C PF00552.21 EMC87867.1 - 1.4e-06 27.5 1.7 2.3e-06 26.8 1.7 1.3 1 0 0 1 1 1 1 Integrase DNA binding domain TssC PF17541.2 EMC87868.1 - 0.016 14.1 0.2 0.017 13.9 0.2 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssC, VipB SNF2_N PF00176.23 EMC87869.1 - 2.3e-68 230.5 0.3 4.6e-68 229.5 0.3 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain CDH1_2_SANT_HL1 PF18375.1 EMC87869.1 - 5.1e-33 113.6 0.0 5.1e-33 113.6 0.0 4.6 4 1 1 5 5 5 1 CDH1/2 SANT-Helical linker 1 Chromo PF00385.24 EMC87869.1 - 2.1e-28 98.0 9.3 4.5e-18 64.9 0.1 4.1 4 0 0 4 4 4 2 Chromo (CHRromatin Organisation MOdifier) domain DUF4208 PF13907.6 EMC87869.1 - 3.2e-27 94.8 2.4 3.2e-27 94.8 2.4 2.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4208) Helicase_C PF00271.31 EMC87869.1 - 6.7e-20 71.5 0.0 1.8e-19 70.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain CHDCT2 PF08074.11 EMC87869.1 - 0.0081 16.3 0.0 0.0081 16.3 0.0 3.0 4 0 0 4 4 4 1 CHDCT2 (NUC038) domain RIO1 PF01163.22 EMC87870.1 - 1.1e-52 178.3 2.1 1.1e-52 178.3 2.1 1.9 2 0 0 2 2 2 1 RIO1 family Rio2_N PF09202.11 EMC87870.1 - 5.9e-34 116.1 3.1 8.9e-33 112.4 0.3 2.8 2 0 0 2 2 2 1 Rio2, N-terminal APH PF01636.23 EMC87870.1 - 1e-08 35.4 3.2 5.1e-05 23.3 0.7 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EMC87870.1 - 1.3e-07 31.2 2.9 3.1e-06 26.7 2.9 2.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.11 EMC87870.1 - 0.0027 17.4 0.0 0.0047 16.6 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) SH2 PF00017.24 EMC87871.1 - 6.9e-18 64.5 0.1 1e-17 64.0 0.1 1.3 1 0 0 1 1 1 1 SH2 domain zf-RING_2 PF13639.6 EMC87872.1 - 2.1e-12 47.2 9.9 2.1e-12 47.2 9.9 2.1 3 0 0 3 3 2 1 Ring finger domain zf-rbx1 PF12678.7 EMC87872.1 - 3.1e-08 33.8 8.8 3.1e-08 33.8 8.8 1.9 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EMC87872.1 - 1e-07 31.6 6.0 1e-07 31.6 6.0 1.9 2 0 0 2 2 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EMC87872.1 - 1.1e-07 31.5 9.6 2.5e-07 30.4 9.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC87872.1 - 7.6e-07 28.9 9.2 1.5e-06 28.0 9.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC87872.1 - 1.9e-06 27.7 7.4 3.9e-06 26.7 7.4 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EMC87872.1 - 1.9e-05 24.4 7.4 1.9e-05 24.4 7.4 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC87872.1 - 0.00053 20.0 5.3 0.0015 18.5 5.3 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EMC87872.1 - 0.0013 18.7 3.2 0.0013 18.7 3.2 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EMC87872.1 - 0.011 15.6 8.4 0.011 15.6 8.4 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C3H2C3 PF17122.5 EMC87872.1 - 0.092 12.8 2.9 0.3 11.1 2.9 1.9 1 0 0 1 1 1 0 Zinc-finger Zn_ribbon_17 PF17120.5 EMC87872.1 - 0.097 12.3 7.4 0.21 11.2 7.4 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type RINGv PF12906.7 EMC87872.1 - 0.41 10.8 9.5 0.82 9.8 9.5 1.5 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 EMC87872.1 - 0.99 9.6 7.5 3.2 8.0 7.5 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 EMC87872.1 - 3.6 7.5 7.9 9.8 6.1 7.9 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.11 EMC87872.1 - 8.8 6.7 8.5 10 6.5 7.2 1.8 2 0 0 2 2 1 0 RING-like domain PRY PF13765.6 EMC87873.1 - 8.3e-09 35.0 0.1 8.3e-09 35.0 0.1 2.1 2 0 0 2 2 2 1 SPRY-associated domain SPRY PF00622.28 EMC87874.1 - 1.5e-07 31.6 0.0 1.7e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 SPRY domain NeuB PF03102.14 EMC87875.1 - 6.8e-80 268.0 0.0 8.2e-80 267.7 0.0 1.1 1 0 0 1 1 1 1 NeuB family SAF PF08666.12 EMC87875.1 - 1.1e-07 32.4 0.2 2.1e-07 31.5 0.2 1.5 1 0 0 1 1 1 1 SAF domain ChapFlgA PF13144.6 EMC87875.1 - 0.0048 16.9 0.0 0.011 15.8 0.0 1.5 1 0 0 1 1 1 1 Chaperone for flagella basal body P-ring formation Opiods_neuropep PF01160.18 EMC87875.1 - 0.81 9.8 0.0 0.81 9.8 0.0 2.8 3 0 0 3 3 3 0 Vertebrate endogenous opioids neuropeptide Clathrin_lg_ch PF01086.17 EMC87876.1 - 4.7e-59 200.2 10.3 5.7e-59 200.0 10.3 1.1 1 0 0 1 1 1 1 Clathrin light chain CENP-Q PF13094.6 EMC87876.1 - 7.3e-05 23.0 6.3 0.00012 22.4 6.3 1.3 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit Myc-LZ PF02344.15 EMC87876.1 - 0.0038 17.3 1.4 0.009 16.1 1.4 1.6 1 0 0 1 1 1 1 Myc leucine zipper domain ORC3_N PF07034.11 EMC87876.1 - 0.063 12.4 4.0 0.079 12.0 4.0 1.2 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus BRCT_assoc PF12820.7 EMC87876.1 - 0.091 12.6 4.3 0.15 11.9 4.3 1.4 1 0 0 1 1 1 0 Serine-rich domain associated with BRCT TBCA PF02970.16 EMC87876.1 - 0.75 10.2 9.0 2 8.8 8.6 1.9 1 1 0 1 1 1 0 Tubulin binding cofactor A Epimerase_2 PF02350.19 EMC87877.1 - 4.4e-67 226.4 0.1 6.9e-67 225.8 0.1 1.2 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase ROK PF00480.20 EMC87877.1 - 3.1e-56 191.0 2.1 5.3e-56 190.3 2.1 1.4 1 0 0 1 1 1 1 ROK family Hexokinase_1 PF00349.21 EMC87877.1 - 0.00039 20.4 0.0 0.00077 19.4 0.0 1.4 1 0 0 1 1 1 1 Hexokinase DRTGG PF07085.12 EMC87877.1 - 0.0015 18.3 0.2 0.0051 16.6 0.2 1.9 1 0 0 1 1 1 1 DRTGG domain BcrAD_BadFG PF01869.20 EMC87877.1 - 0.0021 17.6 1.4 0.9 9.0 0.0 2.4 2 0 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family FGGY_N PF00370.21 EMC87877.1 - 0.0061 16.2 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Glucokinase PF02685.16 EMC87877.1 - 0.26 10.3 2.3 0.37 9.7 0.0 2.3 3 0 0 3 3 3 0 Glucokinase PLDc_3 PF13918.6 EMC87878.1 - 6.4e-37 126.9 0.0 1.1e-36 126.1 0.0 1.3 1 0 0 1 1 1 1 PLD-like domain PLDc_2 PF13091.6 EMC87878.1 - 5.1e-21 75.0 0.5 2.1e-11 43.8 0.1 2.2 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EMC87878.1 - 2.2e-13 49.8 4.3 8.8e-09 35.2 0.9 2.4 2 0 0 2 2 2 2 Phospholipase D Active site motif CEP170_C PF15308.6 EMC87879.1 - 4.5e-295 980.6 49.4 4.5e-295 980.6 49.4 2.8 2 0 0 2 2 2 1 CEP170 C-terminus FHA PF00498.26 EMC87879.1 - 5.9e-18 65.0 0.2 1.5e-17 63.7 0.2 1.7 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EMC87879.1 - 8.8e-10 38.8 0.0 2.2e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Transposase_22 PF02994.14 EMC87879.1 - 0.023 14.9 0.8 0.066 13.4 0.8 1.8 1 0 0 1 1 1 0 L1 transposable element RBD-like domain Syntaxin_2 PF14523.6 EMC87879.1 - 8.3 6.8 15.4 3.6 8.0 2.7 4.8 5 0 0 5 5 5 0 Syntaxin-like protein Pkinase PF00069.25 EMC87880.1 - 1.6e-78 263.7 0.0 2.2e-78 263.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87880.1 - 9.5e-36 123.4 0.0 1.4e-35 122.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 EMC87880.1 - 9.2e-17 61.5 0.2 2.2e-16 60.3 0.2 1.7 1 0 0 1 1 1 1 PH domain Pkinase_C PF00433.24 EMC87880.1 - 1.4e-10 41.7 3.3 3.5e-10 40.4 3.3 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 EMC87880.1 - 1e-08 34.9 0.0 8.5e-08 31.9 0.0 2.0 2 0 0 2 2 2 1 Kinase-like PH_11 PF15413.6 EMC87880.1 - 0.0069 16.8 0.6 0.027 14.9 0.1 2.3 3 0 0 3 3 3 1 Pleckstrin homology domain Seadorna_VP7 PF07387.11 EMC87880.1 - 0.045 12.8 0.0 0.076 12.1 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 EMC87880.1 - 0.17 11.8 0.0 0.47 10.3 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Adenylsucc_synt PF00709.21 EMC87882.1 - 1.3e-162 541.6 0.0 1.4e-162 541.4 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase hSac2 PF12456.8 EMC87882.1 - 0.081 12.6 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Inositol phosphatase DUF5442 PF17514.2 EMC87882.1 - 0.098 12.9 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5442) MBF1 PF08523.10 EMC87882.1 - 0.14 12.7 0.0 0.29 11.6 0.0 1.5 1 0 0 1 1 1 0 Multiprotein bridging factor 1 DUF4131 PF13567.6 EMC87885.1 - 0.024 14.3 0.1 0.043 13.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) TMEM61 PF15105.6 EMC87885.1 - 0.047 13.5 0.0 0.08 12.8 0.0 1.4 1 0 0 1 1 1 0 TMEM61 protein family Vinculin PF01044.19 EMC87885.1 - 0.085 11.1 3.5 0.12 10.5 3.5 1.1 1 0 0 1 1 1 0 Vinculin family WBP-1 PF11669.8 EMC87885.1 - 0.089 13.4 0.0 0.089 13.4 0.0 2.5 2 1 1 3 3 3 0 WW domain-binding protein 1 DUF2681 PF10883.8 EMC87885.1 - 0.13 12.7 6.0 0.18 12.2 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) BatD PF13584.6 EMC87885.1 - 0.16 10.7 0.5 0.21 10.3 0.5 1.1 1 0 0 1 1 1 0 Oxygen tolerance DUF1003 PF06210.11 EMC87885.1 - 0.41 10.8 6.4 1.1 9.3 6.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) AAA_32 PF13654.6 EMC87885.1 - 1 8.1 5.0 1.7 7.4 5.0 1.2 1 0 0 1 1 1 0 AAA domain PMC2NT PF08066.12 EMC87885.1 - 1 10.1 4.6 20 5.9 0.1 2.5 2 0 0 2 2 2 0 PMC2NT (NUC016) domain DNA_pol3_gamma3 PF12169.8 EMC87885.1 - 2 8.3 8.6 2.3 8.1 1.4 3.3 4 0 0 4 4 4 0 DNA polymerase III subunits gamma and tau domain III Kinesin PF00225.23 EMC87886.1 - 2.5e-60 204.2 0.0 4.7e-60 203.3 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EMC87886.1 - 1.5e-16 60.6 0.0 5.1e-16 59.0 0.0 1.8 2 0 0 2 2 2 1 Microtubule binding DUF1640 PF07798.11 EMC87886.1 - 2.4 8.2 5.8 5.3 7.1 5.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) Asparaginase PF00710.20 EMC87888.1 - 1.1e-59 201.2 0.0 9.7e-59 198.1 0.0 2.2 2 0 0 2 2 2 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EMC87888.1 - 2.5e-29 101.8 0.0 4.4e-29 101.0 0.0 1.4 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ank_4 PF13637.6 EMC87888.1 - 5.6e-17 61.9 0.2 6.2e-11 42.6 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC87888.1 - 2.7e-15 56.7 0.0 1.3e-13 51.3 0.0 2.8 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC87888.1 - 1.7e-10 41.0 0.0 3.7e-08 33.5 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EMC87888.1 - 3.9e-10 39.7 0.4 2.3e-06 27.8 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EMC87888.1 - 1.3e-08 34.4 0.8 4.5e-05 23.5 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat HA2 PF04408.23 EMC87889.1 - 1.2e-14 54.5 0.0 3.3e-14 53.1 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) TUDOR PF00567.24 EMC87889.1 - 1.6e-14 53.9 0.0 4.8e-14 52.4 0.0 1.9 1 0 0 1 1 1 1 Tudor domain Helicase_C PF00271.31 EMC87889.1 - 7.8e-14 52.0 0.0 2.1e-13 50.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RD3 PF14473.6 EMC87890.1 - 4.2e-51 172.2 1.6 5.7e-51 171.8 1.6 1.1 1 0 0 1 1 1 1 RD3 protein THAP PF05485.12 EMC87890.1 - 0.061 14.3 0.7 0.51 11.3 0.0 2.2 2 0 0 2 2 2 0 THAP domain Mit_proteolip PF08039.11 EMC87891.1 - 7.8e-10 39.1 1.1 7.8e-10 39.0 1.1 1.0 1 0 0 1 1 1 1 Mitochondrial proteolipid Ank_4 PF13637.6 EMC87892.1 - 7.8e-17 61.4 1.4 7.7e-12 45.5 0.6 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC87892.1 - 9e-17 61.4 0.0 1.8e-16 60.4 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) SH3_1 PF00018.28 EMC87892.1 - 1.7e-13 50.0 1.4 3.3e-13 49.0 1.4 1.5 1 0 0 1 1 1 1 SH3 domain Ank PF00023.30 EMC87892.1 - 2.7e-13 49.7 1.4 2.2e-05 24.7 0.2 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 EMC87892.1 - 1.1e-12 46.9 0.7 2.4e-05 24.4 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeat SH3_9 PF14604.6 EMC87892.1 - 2.5e-10 40.0 0.2 6.1e-10 38.8 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC87892.1 - 1.3e-09 37.6 0.0 2.7e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Ank_5 PF13857.6 EMC87892.1 - 4.5e-08 33.2 0.2 1.4e-06 28.4 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) ZFYVE21_C PF16696.5 EMC87893.1 - 3.6e-51 172.2 0.2 4.9e-51 171.8 0.2 1.2 1 0 0 1 1 1 1 Zinc finger FYVE domain-containing protein 21 C-terminus FYVE PF01363.21 EMC87893.1 - 8.1e-12 45.1 23.5 1.5e-11 44.2 23.5 1.5 1 0 0 1 1 1 1 FYVE zinc finger Rad51 PF08423.11 EMC87894.1 - 3.6e-40 137.8 0.0 4.9e-40 137.4 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EMC87894.1 - 1.3e-05 24.8 0.1 0.021 14.3 0.0 2.2 2 0 0 2 2 2 2 recA bacterial DNA recombination protein AAA_25 PF13481.6 EMC87894.1 - 7.6e-05 22.4 0.0 0.00014 21.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EMC87894.1 - 8.3e-05 22.0 0.0 0.00023 20.6 0.0 1.6 1 1 0 1 1 1 1 KaiC RNA_pol_A_CTD PF03118.15 EMC87894.1 - 0.016 15.0 0.1 0.033 13.9 0.1 1.5 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain DUF2315 PF10231.9 EMC87895.1 - 1.4e-26 93.0 0.1 1.7e-26 92.8 0.1 1.0 1 0 0 1 1 1 1 Apoptogenic protein 1 Sugarporin_N PF11471.8 EMC87895.1 - 0.044 13.8 0.6 0.065 13.2 0.6 1.3 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension V-ATPase_G PF03179.15 EMC87895.1 - 0.064 13.8 0.8 0.078 13.5 0.8 1.1 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit BAG PF02179.16 EMC87896.1 - 4.5e-48 161.6 21.2 1e-12 48.3 0.2 5.2 5 0 0 5 5 5 5 BAG domain Snapin_Pallidin PF14712.6 EMC87896.1 - 0.049 14.0 8.1 2.5 8.6 4.6 3.3 2 0 0 2 2 2 0 Snapin/Pallidin PDGF_N PF04692.13 EMC87896.1 - 0.46 11.3 3.9 0.43 11.4 0.2 2.8 3 0 0 3 3 3 0 Platelet-derived growth factor, N terminal region DUF4061 PF13270.6 EMC87896.1 - 5.8 7.3 7.7 7.1 7.0 1.2 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4061) GCD14 PF08704.10 EMC87897.1 - 5.5e-109 363.6 0.0 6.6e-109 363.3 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 EMC87897.1 - 2.4e-07 30.7 0.0 3.5e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EMC87897.1 - 2.6e-05 24.1 0.0 3.8e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 EMC87897.1 - 0.0016 19.1 0.0 0.0029 18.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 EMC87897.1 - 0.0058 17.6 0.0 0.01 16.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltr_RsmB-F PF01189.17 EMC87897.1 - 0.022 14.4 0.0 0.033 13.8 0.0 1.2 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Methyltransf_12 PF08242.12 EMC87897.1 - 0.044 14.5 0.0 0.088 13.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain GCD14_N PF14801.6 EMC87897.1 - 0.05 13.4 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit N-term CMAS PF02353.20 EMC87897.1 - 0.088 12.1 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase ATP-gua_Ptrans PF00217.19 EMC87898.1 - 1.1e-83 279.8 0.0 1.6e-83 279.4 0.0 1.2 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.15 EMC87898.1 - 3.2e-34 117.1 0.1 5.1e-16 58.8 0.0 2.4 2 0 0 2 2 2 2 ATP:guanido phosphotransferase, N-terminal domain eIF-5_eIF-2B PF01873.17 EMC87899.1 - 1.5e-42 144.2 0.6 1.2e-41 141.2 0.1 2.5 3 0 0 3 3 3 1 Domain found in IF2B/IF5 W2 PF02020.18 EMC87899.1 - 8.6e-22 77.1 1.6 8.6e-22 77.1 1.6 2.8 2 1 1 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon Elf1 PF05129.13 EMC87899.1 - 1.1 9.3 4.0 9.4 6.4 0.7 2.9 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like PGA2 PF07543.12 EMC87899.1 - 8.7 6.3 11.7 9.2 6.2 0.6 2.6 2 0 0 2 2 2 0 Protein trafficking PGA2 Sec6 PF06046.13 EMC87900.1 - 0.00044 18.8 0.1 0.0028 16.1 0.0 2.0 2 1 0 2 2 2 1 Exocyst complex component Sec6 Sec6 PF06046.13 EMC87902.1 - 2e-82 277.4 14.1 2.5e-82 277.1 14.1 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec6 HD_2 PF12917.7 EMC87902.1 - 0.18 11.5 4.5 10 5.8 0.6 3.1 3 0 0 3 3 3 0 HD containing hydrolase-like enzyme ScsC_N PF18312.1 EMC87902.1 - 5.2 7.0 7.1 0.79 9.6 2.6 2.0 2 0 0 2 2 2 0 Copper resistance protein ScsC N-terminal domain Sec6 PF06046.13 EMC87903.1 - 1.3e-76 258.3 8.4 1.9e-76 257.7 8.4 1.3 1 0 0 1 1 1 1 Exocyst complex component Sec6 Clusterin PF01093.17 EMC87903.1 - 0.014 14.5 1.9 0.015 14.4 0.6 1.7 2 0 0 2 2 2 0 Clusterin Spore_III_AB PF09548.10 EMC87903.1 - 0.023 14.8 1.7 3.4 7.7 0.1 3.0 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) STD1 PF17235.2 EMC87903.1 - 0.22 11.1 0.1 0.22 11.1 0.1 2.3 3 0 0 3 3 3 0 STD1/MTH1 CNH PF00780.22 EMC87904.1 - 3.1e-72 243.5 0.1 6.5e-72 242.4 0.1 1.6 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.25 EMC87904.1 - 6e-56 189.7 2.3 9.4e-56 189.1 0.0 2.6 2 0 0 2 2 2 1 Protein kinase domain KELK PF15796.5 EMC87904.1 - 2e-31 108.2 20.0 2e-31 108.2 20.0 7.0 6 2 2 8 8 5 1 KELK-motif containing domain of MRCK Ser/Thr protein kinase Pkinase_Tyr PF07714.17 EMC87904.1 - 4.8e-29 101.4 0.0 4.8e-29 101.4 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase DMPK_coil PF08826.10 EMC87904.1 - 2.4e-26 91.6 12.6 2.4e-26 91.6 12.6 9.2 7 2 3 10 10 10 1 DMPK coiled coil domain like C1_1 PF00130.22 EMC87904.1 - 5.1e-10 39.1 6.0 1.2e-09 38.0 6.0 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.6 EMC87904.1 - 6e-07 29.1 0.0 1.8e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 Kinase-like Myosin_tail_1 PF01576.19 EMC87904.1 - 0.00027 18.9 103.7 0.0011 16.9 75.7 3.4 1 1 2 3 3 3 3 Myosin tail PBD PF00786.28 EMC87904.1 - 0.00057 20.2 0.0 0.0027 18.0 0.0 2.3 1 0 0 1 1 1 1 P21-Rho-binding domain Pkinase_C PF00433.24 EMC87904.1 - 0.0035 18.0 0.8 0.0035 18.0 0.8 2.7 2 0 0 2 2 2 1 Protein kinase C terminal domain PH PF00169.29 EMC87904.1 - 0.017 15.6 0.0 0.12 12.8 0.0 2.6 2 0 0 2 2 2 0 PH domain C1_2 PF03107.16 EMC87904.1 - 0.017 15.4 5.0 0.047 14.0 5.0 1.7 1 0 0 1 1 1 0 C1 domain DUF3450 PF11932.8 EMC87904.1 - 0.72 9.1 69.2 0.086 12.1 7.5 5.5 2 1 2 5 5 5 0 Protein of unknown function (DUF3450) Baculo_PEP_C PF04513.12 EMC87904.1 - 5.3 7.1 16.6 2.9 7.9 0.5 4.3 2 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Filament PF00038.21 EMC87904.1 - 8.2 5.9 88.5 2.1 7.9 19.3 5.1 1 1 3 4 4 4 0 Intermediate filament protein Amnionless PF14828.6 EMC87905.1 - 8.8e-105 351.1 0.2 9.9e-105 351.0 0.2 1.0 1 0 0 1 1 1 1 Amnionless VWC PF00093.18 EMC87905.1 - 0.77 10.1 8.2 2.1 8.7 8.2 1.8 1 0 0 1 1 1 0 von Willebrand factor type C domain zf-TRAF PF02176.18 EMC87906.1 - 1.9e-25 89.3 24.7 2.2e-16 60.3 8.1 4.3 1 1 3 4 4 3 2 TRAF-type zinc finger MPS2 PF17060.5 EMC87906.1 - 0.00065 19.1 6.0 0.001 18.5 6.0 1.2 1 0 0 1 1 1 1 Monopolar spindle protein 2 ATG16 PF08614.11 EMC87906.1 - 0.0028 17.9 6.2 0.0028 17.9 6.2 2.2 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) Cast PF10174.9 EMC87906.1 - 0.0034 15.7 11.9 0.0041 15.4 10.7 1.6 1 1 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone Sina PF03145.16 EMC87906.1 - 0.0044 17.0 8.1 0.0044 17.0 8.1 3.7 2 1 2 4 4 3 2 Seven in absentia protein family zf-C3HC4 PF00097.25 EMC87906.1 - 0.0066 16.3 15.8 0.0066 16.3 15.8 2.9 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) FliJ PF02050.16 EMC87906.1 - 0.0076 16.5 8.8 0.014 15.6 8.8 1.5 1 0 0 1 1 1 1 Flagellar FliJ protein zf-C3HC4_2 PF13923.6 EMC87906.1 - 0.022 14.6 14.6 0.022 14.6 14.6 2.9 2 1 1 3 3 1 0 Zinc finger, C3HC4 type (RING finger) Spc7 PF08317.11 EMC87906.1 - 0.022 13.6 14.5 0.033 13.1 14.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Spc29 PF17082.5 EMC87906.1 - 0.065 13.1 6.6 0.039 13.8 4.2 1.7 1 1 0 1 1 1 0 Spindle Pole Component 29 DUF1664 PF07889.12 EMC87906.1 - 0.12 12.4 5.2 0.24 11.4 3.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) KxDL PF10241.9 EMC87906.1 - 0.13 12.6 5.7 0.11 12.8 3.8 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein T3SSipB PF16535.5 EMC87906.1 - 0.13 12.7 3.4 0.12 12.9 1.9 1.6 1 1 0 1 1 1 0 Type III cell invasion protein SipB Tropomyosin_1 PF12718.7 EMC87906.1 - 0.14 12.3 15.6 1.5 9.0 15.2 2.6 1 1 0 1 1 1 0 Tropomyosin like zf-RING_6 PF14835.6 EMC87906.1 - 0.14 12.0 5.7 0.23 11.3 4.2 2.2 2 0 0 2 2 2 0 zf-RING of BARD1-type protein BLOC1_2 PF10046.9 EMC87906.1 - 0.16 12.3 8.3 0.23 11.8 3.9 2.4 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SPATA24 PF15175.6 EMC87906.1 - 0.17 11.8 13.6 0.41 10.5 10.4 2.3 1 1 1 2 2 2 0 Spermatogenesis-associated protein 24 ADIP PF11559.8 EMC87906.1 - 0.24 11.5 16.3 0.081 13.0 10.8 2.3 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Exonuc_VII_L PF02601.15 EMC87906.1 - 1.1 8.8 8.9 1.7 8.2 8.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit TMPIT PF07851.13 EMC87906.1 - 1.6 7.9 6.9 2.8 7.1 6.9 1.5 1 0 0 1 1 1 0 TMPIT-like protein LMBR1 PF04791.16 EMC87906.1 - 2.2 7.1 4.8 3.1 6.6 4.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Phage_GPO PF05929.11 EMC87906.1 - 4.6 6.8 6.4 7.5 6.1 6.4 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Myb_DNA-binding PF00249.31 EMC87908.1 - 4.3e-17 62.0 0.5 2.2e-09 37.4 0.0 3.1 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EMC87908.1 - 1.6e-06 27.9 9.8 0.00094 19.0 0.1 3.3 2 1 0 2 2 2 2 Myb DNA-binding like ELM2 PF01448.24 EMC87908.1 - 7.8e-05 23.3 0.0 7.8e-05 23.3 0.0 2.9 2 1 0 2 2 2 1 ELM2 domain Myb_DNA-bind_6 PF13921.6 EMC87908.1 - 0.00016 21.8 4.0 0.13 12.6 0.2 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain Arnt_C PF18583.1 EMC87908.1 - 0.0088 15.6 0.3 4.2 7.0 0.1 2.7 2 0 0 2 2 2 2 Aminoarabinose transferase C-terminal domain Homeobox_KN PF05920.11 EMC87908.1 - 0.067 13.1 0.1 0.21 11.5 0.1 1.8 1 0 0 1 1 1 0 Homeobox KN domain RR_TM4-6 PF06459.12 EMC87908.1 - 1.4 8.7 12.1 0.24 11.2 6.1 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 PTPRCAP PF15713.5 EMC87908.1 - 7.1 6.9 10.6 0.46 10.8 3.0 2.2 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Ank_5 PF13857.6 EMC87910.1 - 1.5e-07 31.5 0.2 8e-07 29.2 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC87910.1 - 5.9e-05 23.5 0.5 0.00088 19.8 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC87910.1 - 8.1e-05 23.1 0.0 0.00031 21.3 0.0 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EMC87910.1 - 9.9e-05 22.6 2.2 0.00034 20.9 0.1 2.8 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 EMC87910.1 - 0.0032 17.8 2.6 0.044 14.3 0.1 3.5 3 0 0 3 3 3 1 Ankyrin repeat DUF4764 PF15961.5 EMC87912.1 - 1.4e-20 73.7 1.6 1.5e-20 73.6 1.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4764) DUF4764 PF15961.5 EMC87913.1 - 1.8e-28 99.8 0.3 1.9e-28 99.7 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4764) DUF4764 PF15961.5 EMC87914.1 - 8.4e-133 444.8 5.9 9.4e-133 444.6 5.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4764) zf-C2H2 PF00096.26 EMC87914.1 - 0.021 15.3 0.2 0.04 14.4 0.2 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type Pkinase PF00069.25 EMC87915.1 - 3.4e-67 226.6 0.0 4.3e-67 226.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87915.1 - 2e-29 102.6 0.0 3.1e-29 102.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC87915.1 - 0.00067 19.1 0.0 0.001 18.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 EMC87915.1 - 0.023 14.3 0.1 0.081 12.5 0.1 1.8 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EMC87915.1 - 0.028 13.8 0.2 0.059 12.7 0.2 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WD40 PF00400.32 EMC87916.1 - 3.9e-12 46.5 3.7 0.0002 22.1 0.2 5.3 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC87916.1 - 1.9e-08 34.5 0.0 0.55 10.6 0.0 4.2 1 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EMC87916.1 - 0.00041 20.2 0.0 0.82 9.7 0.0 2.5 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 EMC87916.1 - 0.018 14.0 0.0 0.062 12.3 0.0 1.8 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EMC87916.1 - 0.034 14.0 0.0 0.2 11.5 0.0 2.0 1 1 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A B56 PF01603.20 EMC87918.1 - 1.9e-200 666.2 10.8 2.4e-200 665.8 10.8 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 EMC87918.1 - 0.17 11.8 1.8 2.7 7.9 0.2 2.8 1 1 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal T4_deiodinase PF00837.17 EMC87919.1 - 2.5e-54 184.1 0.0 2.8e-54 183.9 0.0 1.0 1 0 0 1 1 1 1 Iodothyronine deiodinase DUF5039 PF16442.5 EMC87919.1 - 0.066 12.7 0.0 0.067 12.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5039) EGF PF00008.27 EMC87920.1 - 4.7e-32 109.9 88.1 1.9e-09 37.6 11.2 6.8 6 0 0 6 6 6 6 EGF-like domain EGF_2 PF07974.13 EMC87920.1 - 1.3e-15 57.5 97.6 0.00037 20.8 9.2 6.4 6 0 0 6 6 6 6 EGF-like domain hEGF PF12661.7 EMC87920.1 - 1.1e-12 48.0 81.4 0.00089 19.8 5.6 7.6 7 0 0 7 7 7 6 Human growth factor-like EGF DUF2448 PF10476.9 EMC87920.1 - 0.077 12.9 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) EGF_CA PF07645.15 EMC87920.1 - 0.13 12.5 77.2 0.18 12.0 9.1 6.7 3 2 2 5 5 5 0 Calcium-binding EGF domain Laminin_EGF PF00053.24 EMC87920.1 - 0.15 12.2 70.8 0.074 13.2 7.5 6.5 3 2 3 6 6 6 0 Laminin EGF domain IFT57 PF10498.9 EMC87921.1 - 0.019 14.0 7.8 0.05 12.6 7.8 1.6 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Spc7 PF08317.11 EMC87921.1 - 0.033 13.1 12.9 0.08 11.8 9.7 2.4 2 0 0 2 2 2 0 Spc7 kinetochore protein HAUS-augmin3 PF14932.6 EMC87921.1 - 0.78 9.3 14.4 0.19 11.3 10.7 2.0 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 DUF1664 PF07889.12 EMC87921.1 - 0.96 9.5 4.7 1.1 9.3 1.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CENP-H PF05837.12 EMC87921.1 - 1.6 9.2 9.8 1.4 9.3 6.3 2.7 1 1 1 2 2 2 0 Centromere protein H (CENP-H) FapA PF03961.13 EMC87921.1 - 1.8 7.1 7.7 3.2 6.3 7.7 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A XhlA PF10779.9 EMC87921.1 - 5.1 7.4 5.1 1.1 9.5 1.3 1.9 2 0 0 2 2 2 0 Haemolysin XhlA WD40 PF00400.32 EMC87922.1 - 1.2e-22 79.8 4.0 7.8e-05 23.4 0.0 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC87922.1 - 6.3e-13 48.8 0.0 5.7e-05 23.3 0.0 4.2 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC87922.1 - 5.2e-09 36.3 0.0 0.002 18.0 0.0 3.3 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EMC87922.1 - 0.00076 18.5 0.4 0.0073 15.3 0.0 2.6 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EMC87922.1 - 0.0056 15.4 0.4 0.019 13.6 0.1 2.0 1 1 0 2 2 2 1 Nucleoporin Nup120/160 tRNA-synt_1b PF00579.25 EMC87923.1 - 2.4e-22 79.6 0.0 4.2e-22 78.8 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) WHEP-TRS PF00458.20 EMC87923.1 - 1.2e-21 76.5 0.2 3e-21 75.3 0.2 1.7 1 0 0 1 1 1 1 WHEP-TRS domain Mito_carr PF00153.27 EMC87925.1 - 1.4e-64 214.1 0.1 2.4e-22 78.6 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.27 EMC87926.1 - 1.2e-63 211.1 1.6 2.7e-23 81.7 0.0 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.19 EMC87926.1 - 0.3 11.5 1.7 1.9 8.9 0.2 2.7 1 1 2 3 3 3 0 Tim17/Tim22/Tim23/Pmp24 family zf-C2H2 PF00096.26 EMC87927.1 - 3.1e-19 68.3 23.3 8.9e-06 25.9 0.4 4.2 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC87927.1 - 1.1e-16 60.4 21.7 2.5e-07 30.8 0.2 4.8 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC87927.1 - 2.7e-13 49.5 20.5 0.01 16.6 0.2 4.3 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 EMC87927.1 - 0.00055 20.1 6.4 1.5 8.9 0.1 3.2 1 1 2 3 3 3 2 Aberrant zinc-finger IBR PF01485.21 EMC87927.1 - 0.0065 16.7 6.7 0.0087 16.3 1.6 2.6 1 1 1 2 2 2 1 IBR domain, a half RING-finger domain zf-TRAF PF02176.18 EMC87927.1 - 0.0065 17.1 12.3 2.6 8.8 0.1 3.3 1 1 2 3 3 3 2 TRAF-type zinc finger Transpos_assoc PF13963.6 EMC87927.1 - 0.0083 16.4 5.6 0.29 11.5 0.1 3.2 2 1 1 3 3 3 1 Transposase-associated domain Raffinose_syn PF05691.12 EMC87927.1 - 0.011 13.6 0.0 0.014 13.3 0.0 1.1 1 0 0 1 1 1 0 Raffinose synthase or seed imbibition protein Sip1 CHORD PF04968.12 EMC87927.1 - 0.014 16.1 11.6 4.3 8.1 2.1 3.7 1 1 3 4 4 4 0 CHORD zinc_ribbon_9 PF14369.6 EMC87927.1 - 0.021 15.1 3.1 0.94 9.8 0.1 3.2 3 0 0 3 3 3 0 zinc-ribbon CCAP PF11105.8 EMC87927.1 - 0.023 14.6 4.5 0.39 10.7 0.7 2.3 1 1 1 2 2 2 0 Arthropod cardioacceleratory peptide 2a zf_UBZ PF18439.1 EMC87927.1 - 0.03 13.9 0.9 1.5 8.5 0.2 3.3 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-C2H2_jaz PF12171.8 EMC87927.1 - 0.034 14.4 12.0 4 7.8 0.4 3.8 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-CGNR PF11706.8 EMC87927.1 - 0.043 13.7 6.9 3 7.8 0.8 3.4 3 1 0 3 3 3 0 CGNR zinc finger zf-C2H2_11 PF16622.5 EMC87927.1 - 0.087 12.6 7.2 1.6 8.5 0.4 3.1 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-met PF12874.7 EMC87927.1 - 0.32 11.5 6.5 4.2 7.9 0.3 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type XPA_N PF01286.18 EMC87927.1 - 0.53 10.4 4.6 1.5 9.0 0.1 3.0 4 0 0 4 4 3 0 XPA protein N-terminal FOXP-CC PF16159.5 EMC87927.1 - 2.6 8.7 7.8 11 6.8 1.9 2.9 3 1 0 3 3 3 0 FOXP coiled-coil domain FA_desaturase PF00487.24 EMC87928.1 - 3.3e-26 92.7 17.9 5.7e-26 91.9 17.9 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.10 EMC87928.1 - 7.2e-06 25.4 0.3 1.8e-05 24.1 0.3 1.8 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) WH1 PF00568.23 EMC87929.1 - 4e-35 120.1 0.5 6e-35 119.6 0.5 1.3 1 0 0 1 1 1 1 WH1 domain VASP_tetra PF08776.11 EMC87929.1 - 1.4e-18 66.2 6.8 1.4e-18 66.2 6.8 1.9 2 0 0 2 2 2 1 VASP tetramerisation domain Ran_BP1 PF00638.18 EMC87929.1 - 0.0021 18.3 0.2 0.0066 16.7 0.0 1.9 2 1 0 2 2 2 1 RanBP1 domain Tmemb_cc2 PF10267.9 EMC87929.1 - 0.0033 16.6 2.8 0.0033 16.6 2.8 1.6 2 0 0 2 2 2 1 Predicted transmembrane and coiled-coil 2 protein Cas9_PI2 PF18070.1 EMC87929.1 - 0.038 14.7 0.2 0.07 13.9 0.2 1.3 1 0 0 1 1 1 0 CRISPR-Cas9 PI domain Kelch_1 PF01344.25 EMC87929.1 - 0.045 13.3 0.1 0.19 11.4 0.0 2.1 2 0 0 2 2 2 0 Kelch motif HELP PF03451.14 EMC87930.1 - 1.6e-31 108.0 0.1 3e-31 107.1 0.1 1.5 1 0 0 1 1 1 1 HELP motif WD40 PF00400.32 EMC87930.1 - 8.8e-28 96.0 41.4 0.00021 22.0 0.8 10.7 10 1 0 10 10 10 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC87930.1 - 5.1e-07 29.9 0.1 0.00015 22.0 0.0 4.5 4 2 2 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain DPPIV_N PF00930.21 EMC87930.1 - 0.019 13.7 0.0 0.044 12.5 0.0 1.6 1 0 0 1 1 1 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region PKcGMP_CC PF16808.5 EMC87930.1 - 0.049 13.5 0.2 0.098 12.5 0.2 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase SlyX PF04102.12 EMC87930.1 - 0.67 10.6 2.5 0.74 10.5 1.3 1.7 2 0 0 2 2 2 0 SlyX PIP49_C PF12260.8 EMC87931.1 - 1.4e-10 41.1 0.0 2.7e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 Nodulin_late PF07127.11 EMC87931.1 - 1.6 9.2 3.8 1.4 9.3 1.3 2.1 2 0 0 2 2 2 0 Late nodulin protein GSDH PF07995.11 EMC87932.1 - 2.5e-39 135.5 0.0 3.1e-39 135.2 0.0 1.1 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase Folate_rec PF03024.14 EMC87932.1 - 1.6e-11 44.3 1.9 1.6e-11 44.3 1.9 1.6 2 0 0 2 2 2 1 Folate receptor family Fz PF01392.22 EMC87932.1 - 0.086 13.5 2.6 0.31 11.7 2.6 1.9 1 1 0 1 1 1 0 Fz domain Cyclin_N PF00134.23 EMC87933.1 - 6.7e-14 51.7 0.0 6.7e-14 51.7 0.0 2.3 3 0 0 3 3 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EMC87933.1 - 0.00013 22.0 0.1 0.00013 22.0 0.1 2.2 1 1 1 2 2 1 1 Cyclin, C-terminal domain DAG_kinase_N PF14513.6 EMC87933.1 - 0.0083 16.4 5.7 0.016 15.5 5.7 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase N-terminus RR_TM4-6 PF06459.12 EMC87933.1 - 0.087 12.6 10.0 0.13 12.0 10.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 AAR2 PF05282.11 EMC87933.1 - 0.47 9.8 6.9 0.67 9.3 6.9 1.1 1 0 0 1 1 1 0 AAR2 protein eIF-3_zeta PF05091.12 EMC87933.1 - 0.93 8.4 8.3 1.3 7.9 8.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 EMC87933.1 - 2.1 7.0 13.8 3.1 6.5 13.8 1.1 1 0 0 1 1 1 0 Presenilin Lin-8 PF03353.15 EMC87933.1 - 4 6.9 15.8 6 6.3 15.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF4834 PF16118.5 EMC87933.1 - 4.4 8.3 8.8 8.4 7.4 8.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Zip PF02535.22 EMC87933.1 - 5 6.2 5.7 6.9 5.8 5.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 EMC87933.1 - 5.3 7.0 9.5 8.5 6.4 9.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Borrelia_P83 PF05262.11 EMC87933.1 - 5.8 5.3 8.3 1.3e+02 0.8 0.0 1.9 2 0 0 2 2 2 0 Borrelia P83/100 protein Band_3_cyto PF07565.13 EMC87933.1 - 10 5.9 9.1 15 5.3 9.1 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Rubis-subs-bind PF09273.11 EMC87934.1 - 5.9e-29 101.4 0.1 1.4e-28 100.2 0.1 1.7 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.28 EMC87934.1 - 4e-13 50.1 1.6 4.6e-13 49.9 0.0 1.9 2 1 0 2 2 2 1 SET domain zf-C2H2 PF00096.26 EMC87935.1 - 6.8e-11 42.0 24.4 4.9e-05 23.5 1.4 4.4 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC87935.1 - 2e-06 28.2 22.6 0.023 15.5 1.4 4.6 4 0 0 4 4 4 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC87935.1 - 6.4e-06 26.4 1.9 6.4e-06 26.4 1.9 4.0 4 0 0 4 4 4 2 Zinc-finger double domain DUF3268 PF11672.8 EMC87935.1 - 0.0036 17.6 1.2 0.0082 16.5 1.2 1.6 1 0 0 1 1 1 1 zinc-finger-containing domain FYVE PF01363.21 EMC87935.1 - 0.0068 16.5 5.9 0.12 12.5 0.5 3.3 3 0 0 3 3 3 1 FYVE zinc finger zf-H2C2_5 PF13909.6 EMC87935.1 - 0.013 15.2 8.1 0.053 13.3 8.1 2.1 1 0 0 1 1 1 0 C2H2-type zinc-finger domain NOA36 PF06524.12 EMC87935.1 - 0.051 12.9 7.2 0.08 12.3 7.2 1.2 1 0 0 1 1 1 0 NOA36 protein zf-Di19 PF05605.12 EMC87935.1 - 0.36 11.2 11.3 2.9 8.2 6.4 2.7 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 EMC87935.1 - 1.5 9.2 14.9 13 6.2 0.1 3.1 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 EMC87935.1 - 5.1 7.3 9.0 52 4.1 3.9 3.8 3 1 0 3 3 3 0 Zinc ribbon domain DUF2256 PF10013.9 EMC87935.1 - 6.7 6.9 8.4 9.3 6.5 0.5 2.8 3 0 0 3 3 2 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-met PF12874.7 EMC87935.1 - 9.4 6.8 22.1 0.19 12.2 1.0 3.6 3 0 0 3 3 2 0 Zinc-finger of C2H2 type Pkinase PF00069.25 EMC87937.1 - 1.7e-14 53.8 0.0 2.9e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87937.1 - 4.6e-08 32.7 0.1 3.3e-07 29.9 0.0 2.5 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC87937.1 - 0.0023 16.8 2.9 0.015 14.1 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EMC87937.1 - 0.031 14.2 0.1 0.17 11.8 0.0 2.2 3 0 0 3 3 3 0 Phosphotransferase enzyme family EcKinase PF02958.20 EMC87937.1 - 0.052 12.9 0.0 0.087 12.1 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase Kinase-like PF14531.6 EMC87937.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like PAP_central PF04928.17 EMC87938.1 - 4.7e-117 389.3 0.0 1.1e-116 388.2 0.0 1.6 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 EMC87938.1 - 1.8e-24 86.3 8.0 5.8e-19 68.3 0.0 2.8 2 1 1 3 3 3 2 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 EMC87938.1 - 8.3e-14 51.7 0.1 2e-13 50.4 0.1 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain UPF0058 PF01893.16 EMC87939.1 - 0.032 14.5 0.1 0.056 13.7 0.1 1.5 1 1 0 1 1 1 0 Uncharacterised protein family UPF0058 LAGLIDADG_1 PF00961.19 EMC87939.1 - 0.12 13.3 0.2 0.24 12.4 0.1 1.5 1 1 1 2 2 2 0 LAGLIDADG endonuclease DUF727 PF05303.12 EMC87940.1 - 4.9e-32 110.1 0.0 5.9e-32 109.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF727) 7tm_1 PF00001.21 EMC87941.1 - 2.4e-52 177.9 14.7 3e-52 177.6 14.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC87941.1 - 0.00012 21.8 19.1 0.00012 21.8 19.1 1.6 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.21 EMC87942.1 - 6e-49 166.7 32.0 7e-49 166.5 32.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Glutaredoxin PF00462.24 EMC87943.1 - 1.9e-05 24.8 0.2 0.00021 21.4 0.0 2.0 2 0 0 2 2 2 1 Glutaredoxin DUF2639 PF11121.8 EMC87943.1 - 0.13 12.3 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2639) CH PF00307.31 EMC87944.1 - 9.7e-45 151.2 0.3 4.1e-21 75.2 0.3 2.1 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EMC87944.1 - 5.8e-08 32.5 0.0 0.00093 19.0 0.0 2.5 2 0 0 2 2 2 2 CAMSAP CH domain CH_2 PF06294.11 EMC87944.1 - 0.005 16.9 0.1 0.36 11.0 0.0 2.3 2 0 0 2 2 2 2 CH-like domain in sperm protein DUF4607 PF15380.6 EMC87945.1 - 0.074 12.5 0.5 0.074 12.5 0.5 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4607) DUF5128 PF17170.4 EMC87945.1 - 0.12 11.5 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 6-bladed beta-propeller Ribonuclease_3 PF00636.26 EMC87946.1 - 6.8e-70 232.4 0.6 7.2e-44 148.7 0.0 3.3 3 1 0 3 3 3 2 Ribonuclease III domain PAZ PF02170.22 EMC87946.1 - 8.8e-40 135.7 0.6 5.2e-39 133.2 0.2 2.5 2 0 0 2 2 2 1 PAZ domain Ribonucleas_3_3 PF14622.6 EMC87946.1 - 7.6e-25 87.5 0.0 1.5e-16 60.7 0.0 3.7 3 1 0 3 3 3 2 Ribonuclease-III-like Dicer_dimer PF03368.14 EMC87946.1 - 1.7e-24 85.8 0.0 7.1e-24 83.8 0.0 2.2 2 0 0 2 2 2 1 Dicer dimerisation domain Helicase_C PF00271.31 EMC87946.1 - 4.8e-18 65.5 0.1 1.8e-17 63.6 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC87946.1 - 6.8e-14 52.2 0.0 1.9e-13 50.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EMC87946.1 - 1.3e-13 51.1 0.3 2.8e-13 50.0 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF2075 PF09848.9 EMC87946.1 - 0.014 14.7 0.0 0.026 13.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) dsrm PF00035.26 EMC87946.1 - 0.073 13.8 0.0 0.36 11.6 0.0 2.3 1 0 0 1 1 1 0 Double-stranded RNA binding motif Flavi_DEAD PF07652.14 EMC87946.1 - 0.13 12.3 0.0 0.9 9.5 0.0 2.2 2 0 0 2 2 2 0 Flavivirus DEAD domain Serpin PF00079.20 EMC87947.1 - 2.5e-115 385.8 0.4 2.8e-115 385.6 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF4198 PF10670.9 EMC87947.1 - 0.011 16.1 0.0 0.017 15.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4198) Serpin PF00079.20 EMC87948.1 - 4.3e-115 385.0 0.4 4.8e-115 384.8 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 EMC87949.1 - 1.8e-114 382.9 0.9 2e-114 382.8 0.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 EMC87950.1 - 1.3e-74 251.8 1.8 1.4e-74 251.7 1.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 EMC87952.1 - 8e-121 403.8 5.2 9e-121 403.7 5.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 EMC87953.1 - 1.8e-103 346.7 7.6 2e-103 346.6 7.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) HEAT PF02985.22 EMC87954.1 - 1.1e-14 53.3 3.6 0.00055 20.0 0.1 7.5 7 0 0 7 7 7 3 HEAT repeat HEAT_2 PF13646.6 EMC87954.1 - 1.1e-05 25.7 0.8 0.00032 21.0 0.0 3.7 4 1 0 5 5 5 1 HEAT repeats Vac14_Fab1_bd PF12755.7 EMC87954.1 - 3.2e-05 24.4 3.7 1.5 9.5 0.1 4.7 3 1 0 4 4 4 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EMC87954.1 - 0.033 14.7 7.8 0.88 10.2 0.1 5.1 5 1 0 6 6 6 0 HEAT-like repeat Ipi1_N PF12333.8 EMC87954.1 - 0.054 14.1 1.4 4.6 7.9 0.1 3.9 3 0 0 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation Caa3_CtaG PF09678.10 EMC87954.1 - 0.11 11.9 0.2 0.18 11.2 0.2 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) Arm PF00514.23 EMC87954.1 - 0.2 11.8 4.3 2.3 8.4 0.1 3.8 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Ank_2 PF12796.7 EMC87955.1 - 1.7e-64 214.4 19.6 8.8e-16 58.3 0.1 6.1 1 1 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC87955.1 - 3.4e-49 164.6 8.4 1.9e-09 37.9 0.0 8.5 5 3 4 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC87955.1 - 6e-44 143.0 11.8 0.00015 22.0 0.0 11.5 11 0 0 11 11 11 9 Ankyrin repeat Ank PF00023.30 EMC87955.1 - 1.5e-30 104.3 15.6 0.0019 18.6 0.0 10.9 9 2 2 11 11 11 9 Ankyrin repeat Ank_5 PF13857.6 EMC87955.1 - 1e-29 102.2 14.2 4e-09 36.6 0.3 9.5 2 1 9 11 11 11 9 Ankyrin repeats (many copies) SOCS_box PF07525.16 EMC87955.1 - 2.8e-09 37.2 6.4 6.6e-09 36.0 6.4 1.7 1 0 0 1 1 1 1 SOCS box UIM PF02809.20 EMC87955.1 - 0.12 12.4 0.4 0.25 11.3 0.4 1.6 1 0 0 1 1 1 0 Ubiquitin interaction motif FAM181 PF15238.6 EMC87956.1 - 1e-74 252.0 21.1 2.7e-41 142.3 3.1 2.0 1 1 1 2 2 2 2 FAM181 PRIMA1 PF16101.5 EMC87957.1 - 2.4e-61 205.1 13.3 2.9e-61 204.8 13.3 1.1 1 0 0 1 1 1 1 Proline-rich membrane anchor 1 Cadherin_C_2 PF16492.5 EMC87957.1 - 0.0043 17.8 0.1 0.009 16.7 0.1 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal S1FA PF04689.13 EMC87957.1 - 0.02 15.0 0.0 0.034 14.3 0.0 1.3 1 0 0 1 1 1 0 DNA binding protein S1FA TMEM154 PF15102.6 EMC87957.1 - 0.039 13.8 0.0 0.053 13.4 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family OATP PF03137.20 EMC87957.1 - 0.05 11.9 0.1 1.8 6.7 0.0 1.9 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family EphA2_TM PF14575.6 EMC87957.1 - 0.053 14.4 0.2 0.088 13.7 0.2 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Rax2 PF12768.7 EMC87957.1 - 0.057 12.9 1.2 0.098 12.1 1.1 1.4 1 1 0 1 1 1 0 Cortical protein marker for cell polarity LYRIC PF15686.5 EMC87957.1 - 0.057 13.0 0.2 0.28 10.7 0.1 1.8 2 0 0 2 2 2 0 Lysine-rich CEACAM1 co-isolated protein family TMEM132D_C PF15706.5 EMC87957.1 - 0.11 12.3 0.2 0.18 11.6 0.2 1.3 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Ly49 PF08391.10 EMC87957.1 - 0.11 12.8 0.1 0.17 12.2 0.1 1.2 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region FAM176 PF14851.6 EMC87957.1 - 0.12 12.0 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 FAM176 family UNC-79 PF14776.6 EMC87958.1 - 2.6e-06 26.5 0.1 5.5e-06 25.4 0.1 1.5 1 1 1 2 2 2 1 Cation-channel complex subunit UNC-79 BTB PF00651.31 EMC87959.1 - 3.5e-25 88.4 0.4 6.1e-14 52.2 0.1 3.5 2 1 0 2 2 2 2 BTB/POZ domain BACK PF07707.15 EMC87959.1 - 1.3e-10 41.2 0.2 4e-10 39.7 0.2 1.8 1 0 0 1 1 1 1 BTB And C-terminal Kelch PHD PF00628.29 EMC87960.1 - 0.0013 18.6 4.8 0.0013 18.6 4.8 3.3 3 1 0 3 3 3 1 PHD-finger TMEM251 PF15190.6 EMC87961.1 - 1.3e-69 232.1 2.7 1.4e-69 231.9 2.7 1.0 1 0 0 1 1 1 1 Transmembrane protein 251 DUF4064 PF13273.6 EMC87961.1 - 0.0013 18.9 0.0 0.002 18.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4064) AA_permease PF00324.21 EMC87961.1 - 0.012 14.2 0.2 0.017 13.7 0.2 1.2 1 0 0 1 1 1 0 Amino acid permease TctB PF07331.11 EMC87961.1 - 0.081 13.2 2.6 0.46 10.8 2.8 1.8 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family DUF4131 PF13567.6 EMC87961.1 - 0.11 12.1 3.0 1.2 8.7 2.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF4133 PF13571.6 EMC87961.1 - 0.17 12.2 0.8 0.45 10.9 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4133) DUF5542 PF17696.1 EMC87961.1 - 1.4 9.1 3.5 16 5.7 0.5 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5542) Ins134_P3_kin PF05770.11 EMC87962.1 - 6.2e-83 277.2 0.1 9.2e-83 276.7 0.1 1.3 1 0 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain Ins134_P3_kin_N PF17927.1 EMC87962.1 - 1.3e-18 67.2 1.4 4.9e-18 65.3 0.5 2.3 2 0 0 2 2 2 1 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain RimK PF08443.11 EMC87962.1 - 0.00024 20.8 0.1 0.58 9.7 0.0 2.7 2 1 1 3 3 3 2 RimK-like ATP-grasp domain Granin PF01271.17 EMC87963.1 - 6.2e-36 124.5 26.5 8.1e-23 81.2 19.9 3.1 2 1 1 3 3 3 2 Granin (chromogranin or secretogranin) Golgin_A5 PF09787.9 EMC87964.1 - 4.5e-139 463.1 28.6 4.5e-139 463.1 28.6 4.0 3 1 2 5 5 5 2 Golgin subfamily A member 5 Spc7 PF08317.11 EMC87964.1 - 0.00012 21.1 93.0 0.0097 14.8 12.3 5.2 2 1 3 5 5 5 3 Spc7 kinetochore protein PKcGMP_CC PF16808.5 EMC87964.1 - 0.013 15.3 1.0 0.013 15.3 1.0 4.9 5 0 0 5 5 5 0 Coiled-coil N-terminus of cGMP-dependent protein kinase HIP1_clath_bdg PF16515.5 EMC87964.1 - 0.022 15.4 14.1 0.022 15.4 14.1 6.8 2 1 5 8 8 8 0 Clathrin-binding domain of Huntingtin-interacting protein 1 HOOK PF05622.12 EMC87964.1 - 0.27 9.3 90.8 0.079 11.1 30.4 2.6 2 1 1 3 3 3 0 HOOK protein Peptidase_C13 PF01650.18 EMC87965.1 - 7.8e-117 389.3 1.6 1.2e-116 388.7 1.6 1.2 1 0 0 1 1 1 1 Peptidase C13 family DUF2675 PF11247.8 EMC87965.1 - 0.039 14.1 0.0 0.13 12.4 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2675) VPS9 PF02204.18 EMC87966.1 - 1.2e-27 96.1 1.2 1.6e-27 95.7 0.0 1.8 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain RA PF00788.23 EMC87966.1 - 2.4e-05 24.9 0.6 8.1e-05 23.2 0.0 2.1 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain SH2 PF00017.24 EMC87966.1 - 0.05 13.7 0.1 0.23 11.6 0.0 2.2 2 0 0 2 2 2 0 SH2 domain Lactamase_B_6 PF16661.5 EMC87967.1 - 1.8e-63 213.5 0.0 4.5e-63 212.2 0.0 1.6 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 EMC87967.1 - 1.1e-42 146.2 1.8 5.8e-42 143.7 0.0 2.2 2 0 0 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 EMC87967.1 - 2.1e-20 73.1 0.0 4.3e-20 72.0 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 EMC87967.1 - 4.7e-15 55.3 0.0 9.7e-15 54.3 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 EMC87967.1 - 2.1e-06 27.9 0.0 4.6e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EMC87967.1 - 8.3e-05 22.2 0.0 0.00018 21.1 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 EMC87967.1 - 0.0018 17.6 0.1 0.018 14.3 0.0 2.4 2 1 0 2 2 2 1 Putative beta-lactamase-like family NADH_oxidored PF08040.11 EMC87968.1 - 3e-35 119.7 0.1 3.2e-35 119.6 0.1 1.0 1 0 0 1 1 1 1 MNLL subunit Josephin PF02099.17 EMC87969.1 - 1.2e-53 181.5 1.5 1.5e-53 181.3 0.0 1.8 2 0 0 2 2 2 1 Josephin SUIM_assoc PF16619.5 EMC87969.1 - 4.6e-14 52.2 9.0 1.2e-13 50.9 9.0 1.7 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 UIM PF02809.20 EMC87969.1 - 3.7e-11 42.2 27.3 5e-05 22.9 0.8 4.8 4 0 0 4 4 4 3 Ubiquitin interaction motif TolA_bind_tri PF16331.5 EMC87970.1 - 6.4e-05 22.9 2.2 6.4e-05 22.9 2.2 21.4 14 5 10 24 24 24 2 TolA binding protein trimerisation Lebercilin PF15619.6 EMC87970.1 - 0.00046 19.9 13.8 0.00046 19.9 13.8 15.5 7 3 7 14 14 14 3 Ciliary protein causing Leber congenital amaurosis disease DUF4407 PF14362.6 EMC87970.1 - 0.001 18.5 10.3 0.001 18.5 10.3 12.0 1 1 10 12 12 12 2 Domain of unknown function (DUF4407) Rootletin PF15035.6 EMC87970.1 - 0.0041 17.2 22.4 0.0041 17.2 22.4 13.5 3 2 9 12 12 12 1 Ciliary rootlet component, centrosome cohesion Tropomyosin_1 PF12718.7 EMC87970.1 - 0.008 16.3 13.3 0.008 16.3 13.3 19.4 5 4 11 18 18 18 6 Tropomyosin like Uso1_p115_C PF04871.13 EMC87970.1 - 0.0093 16.3 12.0 0.0093 16.3 12.0 17.7 6 3 11 17 17 17 2 Uso1 / p115 like vesicle tethering protein, C terminal region NPV_P10 PF05531.12 EMC87970.1 - 0.021 15.3 0.7 0.021 15.3 0.7 18.1 13 8 4 17 17 17 0 Nucleopolyhedrovirus P10 protein EGF_CA PF07645.15 EMC87971.1 - 1.9e-46 156.0 88.2 2.4e-11 43.6 8.3 7.2 8 0 0 8 8 8 6 Calcium-binding EGF domain cEGF PF12662.7 EMC87971.1 - 2.4e-36 123.3 55.3 4.9e-12 45.5 3.8 7.6 8 0 0 8 8 8 6 Complement Clr-like EGF-like FXa_inhibition PF14670.6 EMC87971.1 - 4.3e-24 84.5 91.7 6.3e-08 32.8 9.7 8.2 8 1 0 8 8 8 4 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 EMC87971.1 - 2.6e-13 49.9 63.8 1e-06 28.8 4.2 7.5 6 1 1 7 7 7 5 EGF domain hEGF PF12661.7 EMC87971.1 - 5.9e-06 26.7 76.7 0.012 16.2 5.1 9.1 8 1 0 8 8 8 4 Human growth factor-like EGF EGF PF00008.27 EMC87971.1 - 2.1e-05 24.7 40.6 0.00024 21.3 8.3 7.9 8 1 0 8 8 8 4 EGF-like domain RANK_CRD_2 PF18278.1 EMC87971.1 - 0.37 11.0 18.4 2.7 8.2 0.2 5.9 5 0 0 5 5 5 0 Receptor activator of the NF-KB cysteine-rich repeat domain 2 C2 PF00168.30 EMC87972.1 - 4.8e-14 52.5 0.0 5.7e-08 33.0 0.0 2.3 2 0 0 2 2 2 2 C2 domain SMK-1 PF04802.15 EMC87973.1 - 3e-80 268.6 7.1 3e-80 268.6 7.1 2.2 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 WH1 PF00568.23 EMC87973.1 - 0.00041 20.2 0.0 0.00094 19.1 0.0 1.6 1 0 0 1 1 1 1 WH1 domain Ran_BP1 PF00638.18 EMC87973.1 - 0.007 16.6 0.0 0.025 14.9 0.0 2.0 1 0 0 1 1 1 1 RanBP1 domain Collagen PF01391.18 EMC87973.1 - 0.032 14.0 1.8 0.05 13.4 1.8 1.2 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) MAGE_N PF12440.8 EMC87973.1 - 0.85 10.3 5.0 2.2 9.0 2.6 2.3 2 0 0 2 2 2 0 Melanoma associated antigen family N terminal 7tm_1 PF00001.21 EMC87974.1 - 9.2e-44 149.7 20.3 9.2e-44 149.7 20.3 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC87974.1 - 1.4e-05 24.9 21.3 3.2e-05 23.7 21.1 1.7 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Sdh_cyt PF01127.22 EMC87974.1 - 2.7 8.0 5.6 0.56 10.3 0.9 2.1 2 0 0 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF4392 PF14336.6 EMC87975.1 - 5.7e-117 390.4 0.0 7.5e-117 390.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4392) DUF1445 PF07286.12 EMC87975.1 - 2.4e-54 183.2 0.1 4.6e-54 182.2 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1445) Pkinase PF00069.25 EMC87976.1 - 3.7e-142 472.3 0.5 8.7e-73 244.9 0.3 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMC87976.1 - 1.5e-67 227.7 0.1 1.1e-33 116.7 0.1 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EMC87976.1 - 3.9e-13 49.4 0.0 4.7e-06 26.1 0.0 3.1 2 2 1 3 3 3 2 Kinase-like APH PF01636.23 EMC87976.1 - 5.1e-13 49.5 4.1 0.0002 21.4 0.0 4.2 2 2 2 4 4 4 4 Phosphotransferase enzyme family Kdo PF06293.14 EMC87976.1 - 5.8e-13 48.7 1.7 2.3e-09 36.9 0.3 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMC87976.1 - 4.5e-09 35.6 8.0 4.6e-06 25.7 0.2 3.1 3 0 0 3 3 3 2 Fungal protein kinase Pkinase_C PF00433.24 EMC87976.1 - 6.2e-08 33.2 1.4 6.2e-08 33.2 1.4 2.1 2 0 0 2 2 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 EMC87976.1 - 7.3e-08 31.7 2.9 0.0041 16.1 0.4 2.5 2 0 0 2 2 2 2 Haspin like kinase domain RIO1 PF01163.22 EMC87976.1 - 5e-07 29.5 1.7 6.6e-05 22.6 0.2 2.5 2 0 0 2 2 2 2 RIO1 family FTA2 PF13095.6 EMC87976.1 - 2e-06 27.6 1.5 1.2 8.7 0.0 3.7 3 1 0 4 4 4 3 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 EMC87976.1 - 0.0014 18.2 1.8 0.014 15.0 0.0 2.9 3 0 0 3 3 3 1 Choline/ethanolamine kinase YrbL-PhoP_reg PF10707.9 EMC87976.1 - 0.02 14.4 0.7 0.81 9.2 0.0 2.8 3 0 0 3 3 3 0 PhoP regulatory network protein YrbL SR-25 PF10500.9 EMC87976.1 - 0.094 12.3 7.0 0.2 11.3 7.0 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CaMBD PF02888.16 EMC87976.1 - 0.36 11.0 2.1 6 7.1 0.4 2.4 2 0 0 2 2 2 0 Calmodulin binding domain EF-hand_1 PF00036.32 EMC87977.1 - 9e-44 143.8 9.7 4.2e-10 38.4 0.4 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EMC87977.1 - 3.8e-37 126.6 2.5 2.5e-19 69.5 0.8 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EMC87977.1 - 4.5e-35 119.3 9.8 4.8e-15 55.1 0.3 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 EMC87977.1 - 8.5e-32 106.4 4.9 1.3e-09 37.2 0.1 4.4 4 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EMC87977.1 - 1.1e-27 94.3 6.8 1.2e-06 27.7 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 EMC87977.1 - 7.5e-16 58.2 0.2 2.3e-09 37.5 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EMC87977.1 - 2.5e-10 40.2 0.4 5.1e-05 23.2 0.1 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EMC87977.1 - 3.7e-08 33.7 0.0 0.0036 17.6 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 EMC87977.1 - 2e-06 28.6 0.0 0.00083 20.2 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.13 EMC87977.1 - 1.1e-05 25.3 0.0 0.042 13.9 0.0 3.1 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 EMC87977.1 - 1.5e-05 25.0 1.0 8.1e-05 22.6 0.1 2.3 2 2 0 2 2 2 1 Ca2+ insensitive EF hand Dockerin_1 PF00404.18 EMC87977.1 - 0.00024 21.2 4.5 0.036 14.2 0.3 3.0 1 1 2 3 3 3 2 Dockerin type I domain DUF1103 PF06513.11 EMC87977.1 - 0.00071 19.3 1.4 0.00082 19.0 1.4 1.2 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) Caleosin PF05042.13 EMC87977.1 - 0.00084 19.3 0.8 0.83 9.6 0.0 3.5 1 1 3 4 4 4 1 Caleosin related protein DUF3349 PF11829.8 EMC87977.1 - 0.0013 19.5 0.5 2.3 9.1 0.0 2.8 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) DUF4497 PF14924.6 EMC87977.1 - 0.002 18.6 0.0 0.88 10.1 0.0 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF4497) TerB PF05099.13 EMC87977.1 - 0.0024 17.9 0.8 0.57 10.1 0.0 2.3 1 1 1 2 2 2 1 Tellurite resistance protein TerB RNA_pol_Rpb4 PF03874.16 EMC87977.1 - 0.0031 17.8 0.7 1.7 9.0 0.1 2.6 3 0 0 3 3 2 1 RNA polymerase Rpb4 DUF5580 PF17743.1 EMC87977.1 - 0.0056 15.3 0.0 0.0056 15.3 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) SurA_N_2 PF13623.6 EMC87977.1 - 0.0074 16.2 0.8 0.39 10.6 0.2 2.2 1 1 1 2 2 2 1 SurA N-terminal domain Poly_export PF02563.16 EMC87977.1 - 0.011 15.9 0.1 0.56 10.5 0.0 3.0 1 1 2 3 3 3 0 Polysaccharide biosynthesis/export protein EF-hand_14 PF17959.1 EMC87977.1 - 0.024 15.0 0.1 9.1 6.7 0.0 2.4 1 1 1 2 2 2 0 EF-hand domain SurA_N_3 PF13624.6 EMC87977.1 - 0.043 13.6 0.4 0.56 10.0 0.2 2.0 1 1 1 2 2 2 0 SurA N-terminal domain Fe_hyd_lg_C PF02906.14 EMC87977.1 - 0.044 13.4 0.8 0.19 11.3 0.8 1.9 1 1 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain MotA_activ PF09114.10 EMC87977.1 - 0.052 13.7 0.3 0.95 9.6 0.0 2.3 1 1 0 2 2 2 0 Transcription factor MotA, activation domain dCache_2 PF08269.11 EMC87977.1 - 0.077 12.2 0.2 6.8 5.8 0.1 2.4 1 1 1 2 2 2 0 Cache domain TetR_C_7 PF14246.6 EMC87977.1 - 0.083 12.9 0.1 7.2 6.7 0.0 2.8 2 1 1 3 3 3 0 AefR-like transcriptional repressor, C-terminal domain RuvA_C PF07499.13 EMC87977.1 - 0.13 12.8 0.1 13 6.4 0.0 3.0 3 0 0 3 3 3 0 RuvA, C-terminal domain CMD PF02627.20 EMC87977.1 - 0.29 11.2 1.0 7 6.8 0.0 2.8 2 2 1 4 4 3 0 Carboxymuconolactone decarboxylase family SapB_1 PF05184.15 EMC87977.1 - 0.37 10.9 1.6 27 4.9 0.0 3.4 4 0 0 4 4 4 0 Saposin-like type B, region 1 NRDE-2 PF08424.10 EMC87978.1 - 3.6e-108 361.5 16.7 6.5e-108 360.7 2.4 3.8 3 1 1 4 4 4 3 NRDE-2, necessary for RNA interference TPR_14 PF13428.6 EMC87978.1 - 1.7e-09 37.7 1.0 0.13 13.2 0.1 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMC87978.1 - 1.6e-05 25.3 0.6 0.22 12.1 0.2 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat IHABP4_N PF16174.5 EMC87978.1 - 0.099 13.2 9.0 0.26 11.9 9.0 1.7 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal Dsh_C PF12316.8 EMC87978.1 - 0.11 12.8 3.7 0.21 12.0 3.7 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal TPR_6 PF13174.6 EMC87978.1 - 1.1 10.1 4.3 57 4.7 0.0 4.9 6 0 0 6 6 6 0 Tetratricopeptide repeat AAA PF00004.29 EMC87979.1 - 2.7e-37 128.2 0.0 7e-37 126.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMC87979.1 - 5.3e-11 42.2 0.6 1e-10 41.2 0.6 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EMC87979.1 - 5e-10 39.2 0.2 1e-09 38.2 0.2 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 EMC87979.1 - 1.8e-05 24.8 0.2 0.00012 22.0 0.1 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 EMC87979.1 - 2.2e-05 23.7 0.0 3.9e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EMC87979.1 - 3.1e-05 23.8 0.0 6e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EMC87979.1 - 3.8e-05 24.0 0.0 0.0024 18.1 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EMC87979.1 - 6.7e-05 23.1 0.0 0.00021 21.4 0.0 1.8 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EMC87979.1 - 7.7e-05 23.1 0.1 0.0029 18.0 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 EMC87979.1 - 0.0017 18.1 0.0 0.0038 17.0 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 EMC87979.1 - 0.0035 17.5 0.0 0.0069 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EMC87979.1 - 0.0035 16.9 0.0 0.03 13.9 0.0 2.2 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_3 PF07726.11 EMC87979.1 - 0.0038 17.1 0.2 0.061 13.2 0.0 2.4 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EMC87979.1 - 0.0063 16.9 0.0 0.015 15.7 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_28 PF13521.6 EMC87979.1 - 0.0063 16.8 0.0 0.014 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMC87979.1 - 0.0065 17.0 0.0 0.014 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EMC87979.1 - 0.011 15.7 0.0 0.031 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 EMC87979.1 - 0.012 14.8 0.0 0.028 13.7 0.0 1.5 1 1 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 EMC87979.1 - 0.014 14.8 0.0 0.029 13.7 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Prot_ATP_OB_N PF17758.1 EMC87979.1 - 0.017 14.7 0.1 0.058 13.0 0.0 1.9 2 0 0 2 2 1 0 Proteasomal ATPase OB N-terminal domain ATPase PF06745.13 EMC87979.1 - 0.025 13.9 0.1 0.25 10.6 0.0 2.4 2 1 1 3 3 3 0 KaiC AAA_24 PF13479.6 EMC87979.1 - 0.028 14.2 0.2 0.08 12.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 EMC87979.1 - 0.031 13.7 0.0 0.078 12.4 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_30 PF13604.6 EMC87979.1 - 0.034 13.9 0.1 0.14 11.9 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EMC87979.1 - 0.035 13.9 0.3 0.97 9.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain SKI PF01202.22 EMC87979.1 - 0.048 13.8 0.0 10 6.2 0.0 2.6 2 0 0 2 2 2 0 Shikimate kinase Sigma54_activat PF00158.26 EMC87979.1 - 0.056 13.1 0.0 0.57 9.9 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_25 PF13481.6 EMC87979.1 - 0.066 12.8 0.5 0.34 10.5 0.1 2.1 1 1 1 2 2 2 0 AAA domain DivIC PF04977.15 EMC87979.1 - 0.075 12.8 0.1 2.1 8.2 0.3 2.3 2 0 0 2 2 2 0 Septum formation initiator NB-ARC PF00931.22 EMC87979.1 - 0.082 12.1 0.1 0.52 9.5 0.0 2.1 2 0 0 2 2 2 0 NB-ARC domain ABC_tran PF00005.27 EMC87979.1 - 0.11 13.1 0.0 0.49 10.9 0.0 2.1 2 0 0 2 2 2 0 ABC transporter TsaE PF02367.17 EMC87979.1 - 0.11 12.5 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 EMC87979.1 - 0.11 11.6 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NACHT PF05729.12 EMC87979.1 - 0.11 12.4 0.1 0.56 10.1 0.0 2.2 2 1 1 3 3 3 0 NACHT domain Ion_trans_2 PF07885.16 EMC87980.1 - 3e-19 68.7 20.3 1.4e-14 53.8 8.8 2.3 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 EMC87980.1 - 0.0095 15.2 5.1 0.0095 15.2 5.1 2.2 2 0 0 2 2 2 2 Ion transport protein Tyr-DNA_phospho PF06087.12 EMC87981.1 - 1.8e-136 455.5 0.0 2.2e-136 455.1 0.0 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase Forkhead PF00250.18 EMC87982.1 - 2.5e-36 123.8 0.1 3.6e-36 123.3 0.1 1.2 1 0 0 1 1 1 1 Forkhead domain TPR_2 PF07719.17 EMC87983.1 - 1.1e-22 78.3 19.4 0.00082 19.3 0.1 8.6 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_1 PF00515.28 EMC87983.1 - 2.4e-22 77.8 17.4 0.00089 19.0 0.3 7.4 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_12 PF13424.6 EMC87983.1 - 2.5e-17 62.9 10.7 0.0004 20.6 0.2 6.1 3 2 3 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 EMC87983.1 - 4e-16 57.8 10.5 0.0011 19.1 0.0 6.6 8 0 0 8 8 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 EMC87983.1 - 1.4e-13 50.4 6.0 0.007 17.1 0.0 7.2 4 3 4 8 8 8 4 Tetratricopeptide repeat TPR_19 PF14559.6 EMC87983.1 - 1.6e-11 44.5 8.4 0.0089 16.5 0.3 5.6 2 2 4 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 EMC87983.1 - 1.2e-09 37.4 12.0 0.016 15.2 0.0 6.6 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 EMC87983.1 - 5.6e-09 36.5 8.4 0.45 11.2 0.2 6.6 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 EMC87983.1 - 2.6e-07 30.5 11.2 0.0064 16.8 0.4 7.5 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_15 PF13429.6 EMC87983.1 - 3.9e-07 29.6 4.2 9.4e-07 28.3 1.3 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMC87983.1 - 7.3e-07 29.4 13.7 0.92 10.3 0.0 6.9 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_9 PF13371.6 EMC87983.1 - 1.2e-06 28.6 0.7 0.36 11.0 0.0 5.0 2 2 3 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 EMC87983.1 - 0.0035 17.1 5.4 0.4 10.6 0.5 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMC87983.1 - 0.0057 16.3 11.5 6.5 6.5 0.7 5.6 3 1 2 5 5 5 1 TPR repeat ANAPC3 PF12895.7 EMC87983.1 - 0.014 15.6 17.5 0.029 14.6 1.7 4.6 2 2 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.8 EMC87983.1 - 0.023 13.6 4.3 0.54 9.1 0.0 3.1 2 1 1 3 3 3 0 NMDA receptor-regulated protein 1 PknG_TPR PF16918.5 EMC87983.1 - 0.026 13.3 0.1 0.055 12.2 0.0 1.6 2 0 0 2 2 2 0 Protein kinase G tetratricopeptide repeat DUF5112 PF17139.4 EMC87983.1 - 5.1 6.5 9.9 0.37 10.2 0.5 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF5112) WD40 PF00400.32 EMC87984.1 - 4.3e-62 204.6 85.7 1.2e-05 25.9 0.1 27.1 30 0 0 30 30 30 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC87984.1 - 3.6e-38 129.7 5.8 2.3e-07 31.0 0.0 13.1 8 3 4 13 13 13 6 Anaphase-promoting complex subunit 4 WD40 domain HELP PF03451.14 EMC87984.1 - 1.5e-35 120.8 0.2 4.2e-17 61.8 0.0 2.4 2 0 0 2 2 2 2 HELP motif Ge1_WD40 PF16529.5 EMC87984.1 - 1.4e-06 27.6 4.7 0.26 10.2 0.0 6.8 4 3 3 7 7 7 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 EMC87984.1 - 1.6e-05 23.8 0.0 0.11 11.2 0.0 4.0 4 0 0 4 4 4 2 Nup133 N terminal like Cytochrom_D1 PF02239.16 EMC87984.1 - 0.00013 20.7 11.3 0.5 8.8 0.0 6.7 7 1 1 8 8 8 2 Cytochrome D1 heme domain Frtz PF11768.8 EMC87984.1 - 0.00077 17.9 0.0 1.3 7.2 0.0 4.0 4 0 0 4 4 4 1 WD repeat-containing and planar cell polarity effector protein Fritz Nup160 PF11715.8 EMC87984.1 - 0.032 12.9 0.0 6.9 5.2 0.0 3.4 3 0 0 3 3 3 0 Nucleoporin Nup120/160 PD40 PF07676.12 EMC87984.1 - 0.13 12.2 1.3 2.1e+02 2.0 0.0 4.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat zf-CCCH_2 PF14608.6 EMC87985.1 - 3.6e-17 62.1 58.3 0.00012 22.3 7.4 5.4 5 0 0 5 5 5 5 RNA-binding, Nab2-type zinc finger zf-TAZ PF02135.16 EMC87985.1 - 1 9.9 22.6 0.95 10.0 3.9 2.9 1 1 1 2 2 2 0 TAZ zinc finger Y_phosphatase PF00102.27 EMC87986.1 - 3e-74 249.5 0.0 5.2e-74 248.8 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase FERM_M PF00373.18 EMC87986.1 - 1.4e-19 70.7 0.9 4.2e-19 69.1 0.9 1.9 1 0 0 1 1 1 1 FERM central domain FERM_C PF09380.10 EMC87986.1 - 3.2e-18 65.9 0.2 7.9e-18 64.6 0.2 1.7 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.10 EMC87986.1 - 3.3e-16 59.0 1.0 1e-15 57.4 0.2 2.3 2 0 0 2 2 2 1 FERM N-terminal domain DSPc PF00782.20 EMC87986.1 - 1.1e-05 25.3 0.0 2.6e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC87986.1 - 0.00069 19.7 0.0 0.0014 18.7 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family MRI PF15325.6 EMC87986.1 - 0.14 13.2 1.2 0.48 11.5 1.2 1.8 1 0 0 1 1 1 0 Modulator of retrovirus infection HSD3 PF15244.6 EMC87987.1 - 1.1e-36 127.3 2.2 1.5e-36 126.8 2.2 1.2 1 0 0 1 1 1 1 Spermatogenesis-associated protein 7, or HSD3 CARD PF00619.21 EMC87987.1 - 0.0085 16.1 0.7 0.017 15.2 0.7 1.4 1 0 0 1 1 1 1 Caspase recruitment domain ZIP4_domain PF18292.1 EMC87987.1 - 0.023 14.7 0.2 0.025 14.5 0.2 1.2 1 0 0 1 1 1 0 Zinc transporter ZIP4 domain PUF PF00806.19 EMC87987.1 - 0.083 12.6 0.2 0.18 11.6 0.1 1.7 2 0 0 2 2 2 0 Pumilio-family RNA binding repeat Ion_trans_2 PF07885.16 EMC87988.1 - 4.9e-36 122.5 21.6 2.5e-18 65.8 8.7 3.2 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 EMC87988.1 - 3.4e-06 26.5 0.3 3.4e-06 26.5 0.3 2.4 2 1 0 2 2 2 1 Ion transport protein DUF2390 PF09523.10 EMC87988.1 - 0.042 14.2 1.0 0.042 14.2 1.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2390) HCMV_UL139 PF12507.8 EMC87988.1 - 0.047 14.1 0.0 0.13 12.7 0.0 1.7 1 1 0 1 1 1 0 Human Cytomegalovirus UL139 protein PDZ_3 PF17815.1 EMC87988.1 - 0.12 12.3 0.2 0.35 10.7 0.0 1.9 2 0 0 2 2 2 0 PDZ domain TssN PF17555.2 EMC87988.1 - 0.23 10.8 4.8 0.87 8.9 1.8 2.2 2 0 0 2 2 2 0 Type VI secretion system, TssN 7tm_1 PF00001.21 EMC87989.1 - 2.3e-43 148.4 20.2 3.3e-43 147.9 20.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC87989.1 - 0.00054 19.8 17.0 0.00076 19.3 17.0 1.2 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC87989.1 - 0.066 12.8 19.4 0.016 14.8 15.2 1.9 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Str PF10326.9 EMC87989.1 - 0.16 11.3 19.8 0.85 8.9 3.4 2.8 1 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Str Glyco_hydro_59 PF02057.15 EMC87990.1 - 2.1e-115 385.0 1.3 2.7e-115 384.6 1.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 Glyco_hydro_59M PF17387.2 EMC87990.1 - 4.7e-52 175.0 0.0 8.4e-52 174.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 central domain CRCB PF02537.15 EMC87990.1 - 0.17 12.2 0.2 3.3 8.1 0.0 2.5 2 0 0 2 2 2 0 CrcB-like protein, Camphor Resistance (CrcB) LRR_8 PF13855.6 EMC87991.1 - 1.6e-33 114.2 31.9 2.8e-13 49.4 6.4 5.4 3 1 2 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 EMC87991.1 - 2.4e-18 65.9 31.4 0.00011 22.5 2.6 7.4 4 2 3 7 7 7 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC87991.1 - 2.4e-10 40.5 0.1 0.084 12.8 0.0 3.5 2 1 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC87991.1 - 4.9e-07 29.4 9.3 0.0075 15.8 0.2 3.3 2 1 1 3 3 3 3 Leucine-rich repeat LRRNT PF01462.18 EMC87991.1 - 7.8e-05 22.2 2.6 7.8e-05 22.2 2.6 3.7 5 0 0 5 5 5 1 Leucine rich repeat N-terminal domain LRRCT PF01463.24 EMC87991.1 - 0.00023 21.5 0.1 0.00069 20.0 0.1 1.9 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain LRR_1 PF00560.33 EMC87991.1 - 0.00053 20.2 18.5 2.9 8.8 0.1 9.5 10 1 0 10 10 10 1 Leucine Rich Repeat fn3 PF00041.21 EMC87991.1 - 0.00076 19.8 0.0 0.0019 18.5 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III domain LRR_6 PF13516.6 EMC87991.1 - 0.067 13.3 27.4 1.4 9.2 0.2 7.4 8 0 0 8 8 8 0 Leucine Rich repeat Syndecan PF01034.20 EMC87991.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain Mucin-like PF16058.5 EMC87993.1 - 1.3e-06 28.5 27.7 0.15 12.2 1.2 5.2 1 1 6 7 7 7 7 Mucin-like Homeodomain PF00046.29 EMC87994.1 - 4.6e-20 71.2 0.4 8.7e-20 70.3 0.4 1.4 1 0 0 1 1 1 1 Homeodomain Pou PF00157.17 EMC87994.1 - 1.5e-17 63.3 0.5 3.7e-17 62.0 0.5 1.7 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox_KN PF05920.11 EMC87994.1 - 0.0024 17.8 0.0 0.0052 16.7 0.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain DUF521 PF04412.13 EMC87994.1 - 0.07 11.8 0.0 0.078 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Nop14 PF04147.12 EMC87995.1 - 0.23 9.7 57.7 0.26 9.4 57.7 1.0 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 EMC87995.1 - 0.95 8.2 40.8 1.1 7.9 40.8 1.1 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 EMC87995.1 - 2.4 7.1 40.3 2.6 7.0 40.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 EMC87995.1 - 4.3 5.5 53.2 5.3 5.2 53.2 1.1 1 0 0 1 1 1 0 CDC45-like protein CCSAP PF15748.5 EMC87995.1 - 4.4 7.4 48.4 6.2 6.9 48.4 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Caldesmon PF02029.15 EMC87995.1 - 5.6 5.6 67.7 8.4 5.0 67.7 1.3 1 0 0 1 1 1 0 Caldesmon Claudin_2 PF13903.6 EMC87996.1 - 1.9e-48 164.8 4.9 2.2e-48 164.6 4.9 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF3139 PF11337.8 EMC87996.1 - 2.3 9.0 4.5 20 5.9 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) DUF4538 PF15061.6 EMC87996.1 - 5.6 6.8 11.1 7.5 6.4 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4538) MFS_1 PF07690.16 EMC87997.1 - 1.8e-39 135.7 22.6 2.3e-39 135.4 22.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMC87997.1 - 3.8e-09 35.9 6.0 3.8e-09 35.9 6.0 2.7 1 1 1 3 3 3 1 Sugar (and other) transporter MFS_1_like PF12832.7 EMC87997.1 - 4.7e-05 22.4 13.1 0.00032 19.7 13.1 1.9 1 1 0 1 1 1 1 MFS_1 like family OATP PF03137.20 EMC87997.1 - 0.00011 20.6 0.9 0.00011 20.6 0.9 3.2 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_4 PF06779.14 EMC87997.1 - 0.00035 20.0 5.4 0.00035 20.0 5.4 2.7 2 1 0 3 3 3 2 Uncharacterised MFS-type transporter YbfB Na_H_Exchanger PF00999.21 EMC87998.1 - 7e-84 281.8 36.0 8.2e-84 281.6 36.0 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family NEXCaM_BD PF16644.5 EMC87998.1 - 9.4e-36 122.5 4.3 9.4e-36 122.5 4.3 1.6 2 0 0 2 2 2 1 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin Tim17 PF02466.19 EMC87998.1 - 0.013 15.9 1.0 0.038 14.4 1.0 1.9 1 0 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family TIR PF01582.20 EMC87999.1 - 2.6e-37 128.3 0.0 5.6e-37 127.2 0.0 1.6 1 0 0 1 1 1 1 TIR domain Ig_6 PF18452.1 EMC87999.1 - 4.7e-28 96.5 0.8 4.4e-23 80.6 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 EMC87999.1 - 2.4e-15 56.9 0.6 4.1e-06 27.3 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 EMC87999.1 - 3.1e-13 49.7 5.6 2.3e-05 24.5 0.1 3.5 3 0 0 3 3 3 3 Immunoglobulin domain TIR_2 PF13676.6 EMC87999.1 - 6.5e-11 42.9 0.0 1.5e-10 41.7 0.0 1.6 1 0 0 1 1 1 1 TIR domain Ig_2 PF13895.6 EMC87999.1 - 5.4e-10 39.5 1.5 0.00013 22.2 0.9 3.4 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 EMC87999.1 - 6.2e-09 35.8 4.6 0.0015 18.6 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin I-set domain C1-set PF07654.15 EMC87999.1 - 0.0018 18.6 0.7 0.39 11.1 0.1 3.1 2 1 0 2 2 2 1 Immunoglobulin C1-set domain V-set PF07686.17 EMC87999.1 - 0.0029 17.8 8.9 0.92 9.7 0.0 4.2 3 2 0 3 3 3 2 Immunoglobulin V-set domain Ig_4 PF16680.5 EMC87999.1 - 0.019 15.2 0.9 0.019 15.2 0.9 4.1 3 2 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 EMC87999.1 - 0.066 13.6 9.2 0.84 10.1 0.3 4.1 3 1 0 3 3 3 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain DUF2180 PF09947.9 EMC87999.1 - 0.077 13.0 0.1 0.21 11.6 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2180) TIR PF01582.20 EMC88000.1 - 2.6e-33 115.3 0.3 4e-33 114.7 0.3 1.2 1 0 0 1 1 1 1 TIR domain Ig_3 PF13927.6 EMC88000.1 - 1e-19 70.9 2.7 1.8e-07 31.6 0.0 3.9 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 EMC88000.1 - 2.3e-18 66.3 1.0 5.2e-07 29.9 0.2 3.6 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 EMC88000.1 - 5.4e-17 61.7 7.5 2.2e-06 27.7 0.1 4.4 4 1 0 4 4 4 3 Immunoglobulin domain I-set PF07679.16 EMC88000.1 - 4.3e-14 52.3 1.2 2.6e-05 24.2 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_6 PF18452.1 EMC88000.1 - 1.2e-12 47.1 0.3 1.4e-10 40.6 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 EMC88000.1 - 7.6e-09 35.7 5.1 0.18 12.0 0.0 4.6 3 2 0 3 3 3 3 Immunoglobulin V-set domain TIR_2 PF13676.6 EMC88000.1 - 4.9e-05 23.9 0.1 0.00014 22.4 0.0 1.7 2 0 0 2 2 2 1 TIR domain V-set_CD47 PF08204.11 EMC88000.1 - 0.00024 21.1 0.2 0.12 12.4 0.0 3.2 3 0 0 3 3 3 1 CD47 immunoglobulin-like domain C2-set_2 PF08205.12 EMC88000.1 - 0.086 12.9 0.0 1.5 9.0 0.0 2.8 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain BiPBP_C PF06832.12 EMC88000.1 - 0.14 12.2 0.0 0.35 11.0 0.0 1.6 1 0 0 1 1 1 0 Penicillin-Binding Protein C-terminus Family Ig_4 PF16680.5 EMC88000.1 - 0.43 10.9 7.9 5.7 7.3 0.1 3.9 4 1 0 4 4 4 0 T-cell surface glycoprotein CD3 delta chain TIR PF01582.20 EMC88001.1 - 8.9e-31 107.0 0.0 1.5e-30 106.3 0.0 1.3 1 0 0 1 1 1 1 TIR domain Ig_3 PF13927.6 EMC88001.1 - 2.5e-19 69.6 3.4 8.8e-06 26.2 0.8 3.9 3 1 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 EMC88001.1 - 2.8e-16 59.3 3.1 0.00019 21.4 0.0 3.7 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC88001.1 - 6.3e-15 55.3 5.7 1.1e-06 28.8 0.4 3.5 3 1 0 3 3 3 2 Immunoglobulin domain Ig_6 PF18452.1 EMC88001.1 - 4.3e-12 45.4 0.1 1.4e-09 37.4 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 EMC88001.1 - 1.2e-11 44.6 3.1 0.00042 20.4 0.0 4.1 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 EMC88001.1 - 5.8e-08 32.9 10.4 0.0081 16.3 0.3 5.5 3 2 1 5 5 5 3 Immunoglobulin V-set domain Ig_5 PF16681.5 EMC88001.1 - 0.00092 19.6 2.1 20 5.7 0.0 4.2 3 1 0 3 3 3 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Lep_receptor_Ig PF06328.11 EMC88001.1 - 0.0048 16.8 1.5 1.8 8.6 0.0 4.3 4 1 1 5 5 5 1 Ig-like C2-type domain Izumo-Ig PF16706.5 EMC88001.1 - 0.0099 15.9 0.1 0.94 9.6 0.0 3.0 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Adeno_E3_CR1 PF02440.15 EMC88001.1 - 0.026 14.3 1.8 0.1 12.4 0.5 2.6 2 0 0 2 2 2 0 Adenovirus E3 region protein CR1 TIR_2 PF13676.6 EMC88001.1 - 0.045 14.4 0.0 0.1 13.2 0.0 1.5 1 0 0 1 1 1 0 TIR domain TIR PF01582.20 EMC88002.1 - 7.8e-35 120.3 0.0 1.4e-34 119.4 0.0 1.3 1 0 0 1 1 1 1 TIR domain Ig_3 PF13927.6 EMC88002.1 - 5.4e-19 68.6 0.1 5.6e-05 23.7 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 EMC88002.1 - 9.8e-16 57.6 0.0 1.2e-05 25.3 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC88002.1 - 4.5e-15 55.7 1.7 8.8e-06 26.0 0.1 3.5 3 1 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 EMC88002.1 - 2.8e-13 49.8 0.5 4.8e-05 23.4 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_6 PF18452.1 EMC88002.1 - 4e-12 45.5 0.2 4.4e-08 32.5 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 EMC88002.1 - 2.7e-06 27.5 6.5 0.22 11.7 0.0 4.9 3 2 2 5 5 5 2 Immunoglobulin V-set domain Ig_5 PF16681.5 EMC88002.1 - 0.0029 18.0 0.1 3.1 8.3 0.0 3.6 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain TIR_2 PF13676.6 EMC88002.1 - 0.0037 17.8 0.0 0.024 15.3 0.0 2.1 1 1 0 1 1 1 1 TIR domain Ig_3 PF13927.6 EMC88003.1 - 9.7e-18 64.6 0.3 2.8e-05 24.6 0.0 3.4 3 1 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 EMC88003.1 - 1.9e-17 63.4 0.0 6e-06 26.5 0.0 3.4 3 1 0 3 3 3 3 Immunoglobulin domain Ig_6 PF18452.1 EMC88003.1 - 1.6e-16 59.6 0.0 5.2e-13 48.3 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC88003.1 - 4.5e-13 49.1 0.0 0.00015 21.8 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 EMC88003.1 - 1.3e-12 47.7 0.1 0.0081 16.3 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 EMC88003.1 - 5.4e-10 39.4 0.9 0.0058 16.8 0.1 4.6 4 1 0 4 4 4 3 Immunoglobulin V-set domain Ig_5 PF16681.5 EMC88003.1 - 0.0068 16.8 2.3 3.1 8.3 0.1 4.1 3 3 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 EMC88003.1 - 0.0093 16.0 0.0 0.2 11.7 0.0 2.4 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain CNH PF00780.22 EMC88004.1 - 3.2e-60 204.1 0.0 5.4e-60 203.3 0.0 1.4 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.25 EMC88004.1 - 1.1e-51 175.7 0.0 3.1e-51 174.3 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC88004.1 - 1.5e-38 132.6 0.3 3.1e-38 131.5 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase FBD PF08387.10 EMC88005.1 - 0.031 14.1 0.0 0.073 13.0 0.0 1.6 1 0 0 1 1 1 0 FBD Pyrid_oxidase_2 PF13883.6 EMC88006.1 - 4.6e-40 137.4 0.0 5.1e-40 137.2 0.0 1.0 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 EMC88006.1 - 0.048 13.9 0.0 0.066 13.4 0.0 1.3 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase zf-RING_2 PF13639.6 EMC88007.1 - 7.2e-13 48.7 7.9 1.2e-12 48.0 7.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EMC88007.1 - 1.4e-10 40.7 2.5 2.8e-10 39.7 2.5 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EMC88007.1 - 2.9e-10 39.8 7.7 4.7e-10 39.1 7.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMC88007.1 - 2e-08 34.4 5.5 5.4e-08 33.0 5.5 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EMC88007.1 - 5.3e-08 32.6 6.9 8.7e-08 31.9 6.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC88007.1 - 8.1e-07 28.9 4.9 1.3e-06 28.3 4.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC88007.1 - 1.8e-06 27.7 5.0 3.1e-06 26.9 5.0 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EMC88007.1 - 3.7e-06 26.8 4.8 6.4e-06 26.1 4.8 1.4 1 0 0 1 1 1 1 RING-type zinc-finger PA PF02225.22 EMC88007.1 - 7.6e-06 25.9 0.0 1.5e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 PA domain zf-C3HC4_3 PF13920.6 EMC88007.1 - 8.5e-05 22.3 4.7 0.00014 21.7 4.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) CrgA PF06781.12 EMC88007.1 - 0.0026 17.8 0.9 0.0062 16.6 0.9 1.6 1 0 0 1 1 1 1 Cell division protein CrgA PspB PF06667.12 EMC88007.1 - 0.016 15.3 1.1 0.023 14.7 0.1 1.8 2 0 0 2 2 2 0 Phage shock protein B zf-ANAPC11 PF12861.7 EMC88007.1 - 0.033 14.3 4.3 0.067 13.3 4.3 1.5 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EMC88007.1 - 0.038 13.6 5.8 0.13 11.9 6.0 1.8 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type CDC24_OB3 PF17244.2 EMC88007.1 - 0.071 12.8 0.2 0.1 12.3 0.2 1.2 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 3 zf-C3H2C3 PF17122.5 EMC88007.1 - 0.12 12.4 5.9 0.32 11.1 5.9 1.8 1 0 0 1 1 1 0 Zinc-finger PHD PF00628.29 EMC88007.1 - 1 9.3 4.9 2.2 8.2 4.9 1.6 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_4 PF15227.6 EMC88007.1 - 1.1 9.5 3.4 3.3 8.0 3.4 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING RINGv PF12906.7 EMC88007.1 - 4.9 7.3 6.2 11 6.3 6.2 1.6 1 0 0 1 1 1 0 RING-variant domain CNOT11 PF10155.9 EMC88008.1 - 5.6e-55 184.8 6.3 8.4e-55 184.3 6.3 1.3 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 11 RabGAP-TBC PF00566.18 EMC88009.1 - 8.7e-45 153.0 0.0 2.2e-44 151.7 0.0 1.7 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.20 EMC88009.1 - 2.8e-42 143.2 2.2 2.8e-21 75.5 0.1 2.5 2 0 0 2 2 2 2 GRAM domain Ribosomal_L31e PF01198.19 EMC88010.1 - 2.8e-53 178.1 1.0 3.8e-53 177.7 1.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L31e Vsr PF03852.15 EMC88010.1 - 0.0074 16.1 0.1 0.016 15.0 0.0 1.6 1 1 0 1 1 1 1 DNA mismatch endonuclease Vsr Phosducin PF02114.16 EMC88012.1 - 2.1e-17 63.0 1.8 2.4e-17 62.8 1.3 1.3 1 1 0 1 1 1 1 Phosducin UPF0175 PF03683.13 EMC88012.1 - 0.0025 17.5 0.6 0.0025 17.5 0.6 2.5 4 0 0 4 4 4 1 Uncharacterised protein family (UPF0175) GOLD_2 PF13897.6 EMC88012.1 - 0.38 11.2 2.3 0.31 11.5 0.9 1.6 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking Histone_H2A_C PF16211.5 EMC88013.1 - 1.8e-13 50.0 0.0 4e-13 48.8 0.0 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EMC88013.1 - 7.1e-13 49.0 0.0 8.6e-13 48.8 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC88013.1 - 1.1e-05 25.5 0.0 1.6e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAFII28 PF04719.14 EMC88013.1 - 0.12 12.5 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 hTAFII28-like protein conserved region Histone PF00125.24 EMC88014.1 - 1.3e-12 48.2 0.0 1.9e-12 47.7 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EMC88014.1 - 6.4e-10 38.6 0.1 2.5e-09 36.7 0.1 1.9 2 0 0 2 2 2 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 EMC88014.1 - 5e-05 23.5 0.0 7e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 EMC88014.1 - 0.0025 18.0 0.1 0.0038 17.4 0.1 1.2 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) tRNA-synt_1f PF01921.18 EMC88014.1 - 0.17 10.8 0.0 0.21 10.5 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (K) Sulfotransfer_2 PF03567.14 EMC88016.1 - 1.1e-51 176.1 0.1 1.4e-51 175.8 0.1 1.1 1 0 0 1 1 1 1 Sulfotransferase family SLC3A2_N PF16028.5 EMC88016.1 - 0.027 14.0 0.7 6.3 6.4 0.0 2.5 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus DUF1075 PF06388.11 EMC88016.1 - 0.1 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1075) LON_substr_bdg PF02190.16 EMC88017.1 - 2e-22 80.1 0.0 3.5e-22 79.3 0.0 1.4 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain zf-C3HC4_2 PF13923.6 EMC88017.1 - 2.1e-10 40.2 15.8 5e-10 39.1 15.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMC88017.1 - 1.6e-09 37.4 9.5 3.4e-09 36.4 9.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC88017.1 - 5.7e-07 29.5 8.5 5.7e-07 29.5 8.5 2.8 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EMC88017.1 - 6.6e-07 29.1 14.7 1.6e-06 27.9 14.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC88017.1 - 7.1e-07 29.5 14.8 2e-06 28.0 14.8 1.8 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EMC88017.1 - 1.5e-05 24.7 11.7 3.4e-05 23.6 11.7 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EMC88017.1 - 1.9e-05 24.6 13.4 4e-05 23.5 13.4 1.6 1 0 0 1 1 1 1 zinc-RING finger domain TPR_2 PF07719.17 EMC88017.1 - 5.6e-05 22.9 0.7 0.069 13.3 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat zf-C3HC4_4 PF15227.6 EMC88017.1 - 6.1e-05 23.1 14.3 6.1e-05 23.1 14.3 2.1 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING TPR_1 PF00515.28 EMC88017.1 - 0.00067 19.4 2.7 7.4 6.6 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat zf-rbx1 PF12678.7 EMC88017.1 - 0.0017 18.6 9.7 0.0044 17.3 9.7 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain U-box PF04564.15 EMC88017.1 - 0.0019 18.3 0.0 0.0043 17.2 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-RING_10 PF16685.5 EMC88017.1 - 0.012 15.7 8.2 0.012 15.7 8.2 1.9 2 0 0 2 2 1 0 zinc RING finger of MSL2 TPR_9 PF13371.6 EMC88017.1 - 0.018 15.2 0.0 0.24 11.6 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-RING_4 PF14570.6 EMC88017.1 - 0.048 13.4 8.6 0.15 11.9 8.6 1.9 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 EMC88017.1 - 0.083 12.8 6.4 0.18 11.7 6.4 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein AF-4 PF05110.13 EMC88018.1 - 5.5e-59 200.4 17.8 7e-48 163.6 6.3 2.0 1 1 1 2 2 2 2 AF-4 proto-oncoprotein BRD4_CDT PF17105.5 EMC88018.1 - 0.41 10.3 2.1 0.73 9.5 2.1 1.4 1 0 0 1 1 1 0 C-terminal domain of bromodomain protein 4 IMS PF00817.20 EMC88020.1 - 6.1e-43 146.4 0.0 1.1e-42 145.6 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 EMC88020.1 - 2.7e-15 57.1 0.0 5.4e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain REV1_C PF16727.5 EMC88020.1 - 5.5e-14 52.3 0.7 1e-13 51.4 0.7 1.5 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain BRCT_2 PF16589.5 EMC88020.1 - 3.6e-10 40.1 0.0 9.4e-10 38.8 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EMC88020.1 - 3.2e-08 33.8 0.0 7.8e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain UBM PF14377.6 EMC88020.1 - 3.3e-07 29.5 4.7 0.0075 15.7 0.2 2.6 2 0 0 2 2 2 2 Ubiquitin binding region LIG3_BRCT PF16759.5 EMC88020.1 - 7.7e-07 29.3 0.0 2.2e-06 27.9 0.0 1.8 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain IMS_HHH PF11798.8 EMC88020.1 - 0.00013 22.1 0.0 0.015 15.6 0.0 2.8 2 0 0 2 2 2 1 IMS family HHH motif PTCB-BRCT PF12738.7 EMC88020.1 - 0.00034 20.5 0.0 0.0009 19.1 0.0 1.8 1 0 0 1 1 1 1 twin BRCT domain Cdd1 PF11731.8 EMC88020.1 - 0.019 15.2 0.0 0.055 13.7 0.0 1.8 1 0 0 1 1 1 0 Pathogenicity locus mCpol PF18182.1 EMC88020.1 - 0.019 15.3 0.0 0.062 13.6 0.0 1.9 1 0 0 1 1 1 0 minimal CRISPR polymerase domain DUF1805 PF08827.11 EMC88020.1 - 0.08 13.3 0.0 0.31 11.4 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1805) GTP_EFTU PF00009.27 EMC88021.1 - 1.6e-34 119.1 0.2 1.6e-34 119.1 0.2 2.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EMC88021.1 - 2e-19 69.6 1.9 3.6e-19 68.8 0.1 2.4 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.6 EMC88021.1 - 9.4e-14 51.1 0.3 2.4e-13 49.8 0.3 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 4 GTP_EFTU_D2 PF03144.25 EMC88021.1 - 5.1e-11 42.8 8.6 1.2e-08 35.2 0.3 4.0 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EMC88021.1 - 1.6e-07 31.4 0.4 2.3e-06 27.7 0.1 3.3 3 0 0 3 3 3 1 50S ribosome-binding GTPase Roc PF08477.13 EMC88021.1 - 0.00028 21.1 0.0 0.00098 19.3 0.0 2.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Thioredoxin PF00085.20 EMC88022.1 - 6.1e-11 42.2 0.1 1.4e-10 41.0 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.16 EMC88022.1 - 1.5e-09 37.2 0.6 2.1e-09 36.7 0.6 1.1 1 0 0 1 1 1 1 Phosducin eIF-3_zeta PF05091.12 EMC88022.1 - 0.01 14.9 0.8 0.013 14.5 0.8 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Thioredoxin_2 PF13098.6 EMC88022.1 - 0.17 12.3 1.2 1 9.8 1.2 2.1 1 1 0 1 1 1 0 Thioredoxin-like domain BAG PF02179.16 EMC88022.1 - 0.41 11.1 5.8 0.89 10.0 5.8 1.6 1 0 0 1 1 1 0 BAG domain FapA PF03961.13 EMC88022.1 - 1.4 7.5 6.2 1.6 7.2 6.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A SLT PF01464.20 EMC88023.1 - 0.012 15.2 0.0 0.021 14.4 0.0 1.4 1 0 0 1 1 1 0 Transglycosylase SLT domain SLT PF01464.20 EMC88024.1 - 4.4e-06 26.3 0.1 9.8e-06 25.2 0.1 1.5 1 1 0 1 1 1 1 Transglycosylase SLT domain Toxin_16 PF07945.11 EMC88024.1 - 0.0054 16.6 0.6 0.012 15.5 0.6 1.5 1 0 0 1 1 1 1 Janus-atracotoxin SLT PF01464.20 EMC88025.1 - 5.1e-05 22.9 0.0 0.00018 21.1 0.0 1.8 1 1 0 1 1 1 1 Transglycosylase SLT domain Ribosomal_L30 PF00327.20 EMC88026.1 - 9.3e-15 54.3 1.0 1.3e-14 53.8 1.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e VWD PF00094.25 EMC88027.1 - 9.1e-75 250.2 29.7 6.3e-30 104.5 3.1 5.1 5 1 0 5 5 5 3 von Willebrand factor type D domain C8 PF08742.11 EMC88027.1 - 1.4e-49 166.3 47.9 3.4e-20 72.2 7.0 7.4 7 2 1 8 8 8 3 C8 domain TIL PF01826.17 EMC88027.1 - 9.9e-21 73.8 54.7 2.4e-11 43.7 14.9 11.3 8 3 1 9 9 9 4 Trypsin Inhibitor like cysteine rich domain VWC PF00093.18 EMC88027.1 - 2.4e-05 24.5 26.2 0.0003 21.0 8.0 11.6 6 4 2 8 8 8 2 von Willebrand factor type C domain Pacifastin_I PF05375.13 EMC88027.1 - 0.0038 16.9 9.9 0.0038 16.9 9.9 7.6 6 1 1 7 7 7 2 Pacifastin inhibitor (LCMII) CUE PF02845.16 EMC88028.1 - 1.3e-14 53.6 0.2 2.4e-14 52.7 0.2 1.5 1 0 0 1 1 1 1 CUE domain C2 PF00168.30 EMC88028.1 - 4.7e-14 52.5 0.0 6.9e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 C2 domain UBA PF00627.31 EMC88028.1 - 0.0014 18.5 0.1 0.003 17.4 0.1 1.6 1 0 0 1 1 1 1 UBA/TS-N domain HTH_8 PF02954.19 EMC88028.1 - 0.068 13.0 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family Pkinase PF00069.25 EMC88029.1 - 1.6e-61 208.0 0.0 2.4e-61 207.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC88029.1 - 3.8e-33 114.9 0.0 5.4e-33 114.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EMC88029.1 - 0.00011 22.3 0.1 0.0012 18.8 0.0 2.4 2 1 1 3 3 3 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EMC88029.1 - 0.00095 18.2 0.2 0.0018 17.3 0.2 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EMC88029.1 - 0.0051 16.2 0.0 0.0078 15.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Choline_kinase PF01633.20 EMC88029.1 - 0.0073 15.9 0.4 0.027 14.1 0.4 1.8 1 1 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.14 EMC88029.1 - 0.038 13.3 0.0 0.069 12.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EMC88029.1 - 0.062 12.9 0.1 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 RIO1 family Mob1_phocein PF03637.17 EMC88030.1 - 3e-59 199.8 5.2 3.7e-59 199.5 5.2 1.0 1 0 0 1 1 1 1 Mob1/phocein family DSPc PF00782.20 EMC88031.1 - 2.3e-44 150.4 0.0 3.4e-44 149.9 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 EMC88031.1 - 1.5e-11 44.7 0.0 3.9e-11 43.4 0.0 1.7 2 0 0 2 2 2 1 Rhodanese-like domain Y_phosphatase PF00102.27 EMC88031.1 - 0.0014 18.2 0.0 0.0023 17.5 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EMC88031.1 - 0.13 12.4 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate CD225 PF04505.12 EMC88032.1 - 2.1e-21 75.8 0.7 3.2e-21 75.2 0.7 1.2 1 0 0 1 1 1 1 Interferon-induced transmembrane protein TMEM237 PF15383.6 EMC88032.1 - 0.023 13.8 0.0 0.039 13.0 0.0 1.4 1 0 0 1 1 1 0 Transmembrane protein 237 ScdA_N PF04405.14 EMC88032.1 - 0.11 12.1 0.7 0.53 10.0 0.3 2.1 1 1 1 2 2 2 0 Domain of Unknown function (DUF542) Internalin_N PF12354.8 EMC88032.1 - 0.25 11.4 0.0 0.25 11.4 0.0 1.9 3 0 0 3 3 3 0 Bacterial adhesion/invasion protein N terminal Asp PF00026.23 EMC88033.1 - 1.9e-128 428.3 0.0 2.2e-128 428.1 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EMC88033.1 - 2e-15 57.5 0.2 6.3e-13 49.3 0.2 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.12 EMC88033.1 - 6.3e-07 29.1 0.1 1.1e-05 25.1 0.0 2.2 2 0 0 2 2 2 1 A1 Propeptide TAXi_C PF14541.6 EMC88033.1 - 6.4e-05 22.8 0.0 0.00017 21.4 0.0 1.7 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 EMC88033.1 - 0.00021 21.9 0.1 7.8 7.2 0.0 3.3 3 0 0 3 3 3 2 Aspartyl protease 5-nucleotidase PF06189.12 EMC88034.1 - 4e-92 307.9 0.0 7.6e-92 307.0 0.0 1.4 1 1 1 2 2 2 2 5'-nucleotidase C2 PF00168.30 EMC88036.1 - 3.8e-52 174.9 2.7 7.9e-28 96.8 0.1 2.2 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.6 EMC88036.1 - 0.00018 21.1 0.0 0.052 13.1 0.0 2.3 2 0 0 2 2 2 2 CEP76 C2 domain DOCK-C2 PF14429.6 EMC88036.1 - 0.00029 20.7 0.4 0.0057 16.5 0.0 2.2 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins PI3K_C2 PF00792.24 EMC88036.1 - 0.0034 17.3 0.1 1 9.2 0.0 2.3 2 0 0 2 2 2 2 Phosphoinositide 3-kinase C2 Adeno_E3_CR2 PF02439.15 EMC88036.1 - 0.0063 16.3 2.2 0.013 15.3 2.2 1.5 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 Cadherin_C_2 PF16492.5 EMC88036.1 - 0.026 15.2 0.6 0.13 13.0 0.1 2.3 3 0 0 3 3 3 0 Cadherin cytoplasmic C-terminal EphA2_TM PF14575.6 EMC88036.1 - 0.045 14.6 0.0 0.11 13.4 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Tweety PF04906.13 EMC88036.1 - 0.053 12.2 1.3 0.092 11.4 1.3 1.3 1 0 0 1 1 1 0 Tweety TMEM52 PF14979.6 EMC88036.1 - 0.16 11.9 1.8 0.42 10.5 1.8 1.6 1 0 0 1 1 1 0 Transmembrane 52 LRRC37AB_C PF14914.6 EMC88036.1 - 0.32 10.9 4.0 0.096 12.6 0.6 1.8 2 1 1 3 3 3 0 LRRC37A/B like protein 1 C-terminal domain TMEM154 PF15102.6 EMC88036.1 - 0.57 10.1 3.2 0.24 11.3 0.3 1.7 2 0 0 2 2 2 0 TMEM154 protein family Troponin PF00992.20 EMC88037.1 - 1.2e-47 161.5 9.0 2e-47 160.9 9.0 1.3 1 0 0 1 1 1 1 Troponin DUF919 PF06034.11 EMC88037.1 - 0.007 16.2 1.6 0.007 16.2 1.6 2.7 2 1 0 2 2 2 1 Nucleopolyhedrovirus protein of unknown function (DUF919) Tup_N PF08581.10 EMC88037.1 - 0.011 16.0 0.6 0.011 16.0 0.6 2.3 3 0 0 3 3 3 0 Tup N-terminal DUF2408 PF10303.9 EMC88037.1 - 0.036 14.6 5.8 0.1 13.2 5.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) FAM167 PF11652.8 EMC88037.1 - 0.38 11.2 4.6 0.23 12.0 0.6 2.3 1 1 2 3 3 3 0 FAM167 DUF4456 PF14644.6 EMC88037.1 - 0.64 9.7 10.5 0.042 13.5 5.6 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4456) MPS2 PF17060.5 EMC88037.1 - 0.67 9.2 7.4 0.037 13.3 2.3 1.4 2 0 0 2 2 2 0 Monopolar spindle protein 2 CENP-F_leu_zip PF10473.9 EMC88037.1 - 1.3 9.0 15.3 0.073 13.1 7.6 2.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cnn_1N PF07989.11 EMC88037.1 - 3.5 7.9 14.8 3.7 7.8 0.5 3.1 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 LMBR1 PF04791.16 EMC88037.1 - 5.7 5.7 4.4 7.7 5.3 4.4 1.4 1 1 0 1 1 1 0 LMBR1-like membrane protein APG6_N PF17675.1 EMC88037.1 - 6.6 7.3 19.2 38 4.8 0.3 2.8 2 1 0 2 2 2 0 Apg6 coiled-coil region DUF3896 PF13035.6 EMC88037.1 - 9.8 6.4 9.4 2.2 8.5 0.2 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF3896) Caldesmon PF02029.15 EMC88038.1 - 1.9e-24 86.3 51.0 2e-15 56.5 42.5 2.9 2 1 1 3 3 3 3 Caldesmon Recep_L_domain PF01030.24 EMC88038.1 - 0.1 12.7 0.1 0.17 12.0 0.1 1.3 1 0 0 1 1 1 0 Receptor L domain DUF4643 PF15485.6 EMC88039.1 - 2.3e-45 155.7 23.5 3.4e-45 155.2 23.5 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4643) Troponin PF00992.20 EMC88041.1 - 1.9e-34 118.8 42.0 2.2e-31 108.9 34.7 2.1 1 1 1 2 2 2 2 Troponin Ribosomal_L23 PF00276.20 EMC88042.1 - 1.1e-15 57.7 0.7 1.7e-15 57.1 0.7 1.2 1 0 0 1 1 1 1 Ribosomal protein L23 Insulin PF00049.18 EMC88046.1 - 4.1e-14 53.3 5.5 1.7e-06 28.9 2.3 2.4 1 1 1 2 2 2 2 Insulin/IGF/Relaxin family IGF2_C PF08365.11 EMC88046.1 - 1.5e-06 28.1 4.1 3.3e-06 27.0 4.1 1.6 1 0 0 1 1 1 1 Insulin-like growth factor II E-peptide Ins_beta PF03488.14 EMC88046.1 - 0.55 10.3 4.7 6.6 6.8 0.1 2.4 2 1 0 2 2 2 0 Nematode insulin-related peptide beta type Insulin PF00049.18 EMC88047.1 - 3.3e-24 85.7 1.0 4.2e-24 85.4 1.0 1.1 1 0 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.14 EMC88047.1 - 0.022 14.7 4.7 0.74 9.9 0.1 2.2 2 0 0 2 2 2 0 Nematode insulin-related peptide beta type Biopterin_H PF00351.21 EMC88048.1 - 5.2e-176 584.5 0.5 6.8e-176 584.1 0.5 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase TOH_N PF12549.8 EMC88048.1 - 5.6e-19 67.4 10.6 1.4e-11 43.9 0.7 3.1 3 0 0 3 3 3 2 Tyrosine hydroxylase N terminal Tetraspanin PF00335.20 EMC88049.1 - 1.4e-14 54.4 8.4 1.7e-14 54.1 8.4 1.1 1 0 0 1 1 1 1 Tetraspanin family ABC2_membrane_2 PF12679.7 EMC88049.1 - 0.29 10.4 5.1 0.054 12.8 1.4 1.6 2 0 0 2 2 2 0 ABC-2 family transporter protein DUF4131 PF13567.6 EMC88049.1 - 7.8 6.1 5.4 0.52 10.0 0.1 1.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Tetraspanin PF00335.20 EMC88050.1 - 8.5e-40 136.9 9.6 1.1e-39 136.5 9.6 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF4282 PF14110.6 EMC88050.1 - 4.1 8.2 11.6 12 6.7 4.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) TSSC4 PF15264.6 EMC88051.1 - 5.1e-28 97.8 0.2 1.1e-27 96.8 0.2 1.6 1 0 0 1 1 1 1 Tumour suppressing sub-chromosomal transferable candidate 4 LSDAT_euk PF18139.1 EMC88052.1 - 2.6e-51 174.6 0.0 4.5e-51 173.8 0.0 1.3 1 0 0 1 1 1 1 SLOG in TRPM LSDAT_prok PF18171.1 EMC88052.1 - 3.4e-15 55.8 0.0 7.5e-15 54.7 0.0 1.5 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote Ion_trans PF00520.31 EMC88052.1 - 1.6e-10 40.7 24.2 8.9e-10 38.2 24.2 2.1 1 1 0 1 1 1 1 Ion transport protein Imm9 PF15587.6 EMC88052.1 - 0.033 13.9 5.0 4.1 7.1 0.4 3.3 3 0 0 3 3 3 0 Immunity protein 9 Mso1_Sec1_bdg PF14475.6 EMC88052.1 - 0.093 12.3 0.0 0.26 10.9 0.0 1.8 1 0 0 1 1 1 0 Sec1-binding region of Mso1 Ion_trans PF00520.31 EMC88053.1 - 1.8e-26 92.9 13.8 2.6e-26 92.4 13.8 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 EMC88053.1 - 9.6e-12 44.7 5.9 9.6e-12 44.7 5.9 2.7 2 1 1 3 3 3 1 Ion channel CD225 PF04505.12 EMC88053.1 - 0.53 10.5 0.1 0.53 10.5 0.1 3.1 3 0 0 3 3 3 0 Interferon-induced transmembrane protein DUF1011 PF06237.12 EMC88053.1 - 2.8 8.3 6.9 15 6.0 2.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1011) MFS_1 PF07690.16 EMC88054.1 - 5.2e-28 98.0 48.8 2.5e-26 92.5 45.0 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_3 PF05977.13 EMC88054.1 - 0.00098 17.6 16.9 0.47 8.8 0.1 3.8 1 1 1 3 3 3 3 Transmembrane secretion effector PH_15 PF17339.2 EMC88055.1 - 1.1e-11 44.5 0.0 1.5e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 PH domain PH PF00169.29 EMC88055.1 - 8.5e-06 26.2 0.1 1.2e-05 25.8 0.1 1.2 1 0 0 1 1 1 1 PH domain NAP PF00956.18 EMC88056.1 - 2.2e-106 355.0 4.7 4.3e-106 354.0 4.7 1.5 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) Muted PF14942.6 EMC88056.1 - 0.049 14.0 0.8 0.049 14.0 0.8 2.1 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein tRNA-synt_1e PF01406.19 EMC88057.1 - 1.7e-128 428.2 0.2 1.7e-128 428.2 0.2 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EMC88057.1 - 4.1e-07 29.1 1.3 0.00033 19.5 0.2 2.6 3 0 0 3 3 3 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EMC88057.1 - 0.0024 16.2 1.2 0.0084 14.4 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Med7 PF05983.11 EMC88057.1 - 0.07 13.2 6.3 0.18 11.8 6.3 1.7 1 0 0 1 1 1 0 MED7 protein WGG PF10273.9 EMC88057.1 - 0.23 12.1 0.8 1.1 10.0 0.2 2.5 2 0 0 2 2 2 0 Pre-rRNA-processing protein TSR2 Senescence_reg PF04520.13 EMC88057.1 - 0.53 11.1 5.2 0.14 13.0 1.6 1.8 2 0 0 2 2 2 0 Senescence regulator TNFR_c6 PF00020.18 EMC88058.1 - 1.9e-10 41.0 24.8 3.4e-10 40.1 4.6 3.2 2 1 1 3 3 3 3 TNFR/NGFR cysteine-rich region PTP_tm PF18861.1 EMC88059.1 - 1.6e-87 292.3 3.2 3.6e-87 291.1 0.1 3.0 3 0 0 3 3 3 1 Transmembrane domain of protein tyrosine phosphatase, receptor type J Y_phosphatase PF00102.27 EMC88059.1 - 9.8e-85 283.9 1.0 1.7e-84 283.1 1.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.21 EMC88059.1 - 2.9e-47 158.9 19.3 3.5e-07 30.5 0.1 7.5 7 0 0 7 7 7 6 Fibronectin type III domain DUF2369 PF10179.9 EMC88059.1 - 1.1e-08 35.3 0.6 11 6.5 0.0 5.8 5 0 0 5 5 5 1 Uncharacterised conserved protein (DUF2369) DUF1297 PF06973.12 EMC88059.1 - 2.4e-06 27.2 0.6 3.4 7.2 0.0 4.9 4 1 0 5 5 5 1 Domain of unknown function (DUF1297) Pur_ac_phosph_N PF16656.5 EMC88059.1 - 1.7e-05 25.3 20.7 0.84 10.3 0.9 6.0 1 1 3 4 4 4 3 Purple acid Phosphatase, N-terminal domain WIF PF02019.18 EMC88059.1 - 7.2e-05 22.5 4.1 13 5.5 0.0 5.3 3 2 1 5 5 5 0 WIF domain GPI-anchored PF10342.9 EMC88059.1 - 7.9e-05 23.3 21.2 0.42 11.4 0.6 6.5 3 2 2 6 6 6 2 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Glucodextran_B PF09136.10 EMC88059.1 - 0.0037 17.6 11.8 24 5.4 0.2 5.6 5 0 0 5 5 5 0 Glucodextranase, domain B DUF4945 PF16303.5 EMC88059.1 - 0.0053 16.7 0.1 36 4.3 0.0 4.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4945) Y_phosphatase3 PF13350.6 EMC88059.1 - 0.0069 16.4 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 EMC88059.1 - 0.0094 15.8 0.0 0.027 14.3 0.0 1.8 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EMC88059.1 - 0.011 15.9 0.0 0.035 14.2 0.0 1.9 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 EMC88059.1 - 0.058 13.0 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF2627 PF11118.8 EMC88059.1 - 0.13 12.9 0.1 0.28 11.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2627) Y_phosphatase PF00102.27 EMC88060.1 - 1.8e-73 247.0 1.0 3.6e-73 246.0 1.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EMC88060.1 - 1.1e-06 28.5 0.0 3.6e-06 26.8 0.0 2.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC88060.1 - 0.0011 19.0 0.0 0.0022 18.0 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family YccF PF03733.13 EMC88060.1 - 0.018 15.8 1.0 0.073 13.8 1.0 2.1 1 0 0 1 1 1 0 Inner membrane component domain PTPlike_phytase PF14566.6 EMC88060.1 - 0.091 12.9 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate Proton_antipo_C PF01010.19 EMC88060.1 - 0.15 11.7 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus CPSase_L_D2 PF02786.17 EMC88060.1 - 0.15 11.5 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain I-set PF07679.16 EMC88061.1 - 0.00023 21.2 0.1 0.0025 17.8 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin I-set domain YhhN PF07947.14 EMC88062.1 - 1.2e-44 152.2 22.8 1.2e-44 152.2 22.8 1.3 1 1 0 1 1 1 1 YhhN family UEV PF05743.13 EMC88063.1 - 1.6e-42 144.2 0.1 2.6e-42 143.5 0.1 1.3 1 0 0 1 1 1 1 UEV domain Ldh_1_N PF00056.23 EMC88063.1 - 3e-22 79.2 0.4 5e-22 78.5 0.4 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EMC88063.1 - 8.2e-11 42.1 0.0 1.4e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain F420_oxidored PF03807.17 EMC88063.1 - 0.051 14.1 0.9 0.22 12.2 0.2 2.2 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent UDPG_MGDP_dh_N PF03721.14 EMC88063.1 - 0.13 11.8 0.5 0.32 10.5 0.5 1.6 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UEV PF05743.13 EMC88064.1 - 1.4e-47 160.5 1.1 1.3e-46 157.4 0.3 2.2 2 0 0 2 2 2 1 UEV domain Vps23_core PF09454.10 EMC88064.1 - 3.8e-28 97.2 0.1 6.7e-28 96.4 0.1 1.4 1 0 0 1 1 1 1 Vps23 core domain UQ_con PF00179.26 EMC88064.1 - 0.00023 20.8 0.3 0.00023 20.8 0.3 2.0 2 0 0 2 2 1 1 Ubiquitin-conjugating enzyme DUF3450 PF11932.8 EMC88064.1 - 0.00068 19.0 8.4 0.0012 18.2 8.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) Macoilin PF09726.9 EMC88064.1 - 0.0063 15.1 2.3 0.0084 14.7 2.3 1.1 1 0 0 1 1 1 1 Macoilin family APG6_N PF17675.1 EMC88064.1 - 0.019 15.5 11.8 0.019 15.5 11.8 1.6 2 0 0 2 2 1 0 Apg6 coiled-coil region GPS2_interact PF15784.5 EMC88064.1 - 0.025 15.0 9.0 0.096 13.1 9.0 1.9 1 1 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain DUF1640 PF07798.11 EMC88064.1 - 0.027 14.5 7.1 0.027 14.5 7.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) ERM PF00769.19 EMC88064.1 - 0.052 13.3 13.9 0.092 12.5 13.9 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Fzo_mitofusin PF04799.13 EMC88064.1 - 0.061 12.9 4.5 0.12 11.9 4.5 1.4 1 0 0 1 1 1 0 fzo-like conserved region Exonuc_VII_L PF02601.15 EMC88064.1 - 0.076 12.6 1.6 0.097 12.2 1.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FapA PF03961.13 EMC88064.1 - 0.082 11.5 5.0 0.11 11.0 5.0 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Prominin PF05478.11 EMC88064.1 - 0.11 10.5 2.1 0.15 10.0 2.1 1.1 1 0 0 1 1 1 0 Prominin SlyX PF04102.12 EMC88064.1 - 0.15 12.7 12.7 0.14 12.8 3.4 3.2 2 1 1 3 3 3 0 SlyX DUF3552 PF12072.8 EMC88064.1 - 0.17 11.3 10.2 0.26 10.7 10.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Spc7 PF08317.11 EMC88064.1 - 0.17 10.7 10.4 0.26 10.1 10.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3492 PF11997.8 EMC88064.1 - 0.32 10.7 0.7 0.48 10.1 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) DUF3782 PF12644.7 EMC88064.1 - 0.35 11.1 5.9 5 7.4 0.0 3.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3782) TMPIT PF07851.13 EMC88064.1 - 0.46 9.7 3.6 0.65 9.2 3.6 1.1 1 0 0 1 1 1 0 TMPIT-like protein Spc24 PF08286.11 EMC88064.1 - 0.51 10.6 12.7 0.81 10.0 5.2 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Fib_alpha PF08702.10 EMC88064.1 - 0.56 10.4 5.0 1 9.5 5.0 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 EMC88064.1 - 0.6 10.2 4.8 1.1 9.3 4.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 EMC88064.1 - 0.6 10.5 11.8 1 9.8 0.8 2.5 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Nsp1_C PF05064.13 EMC88064.1 - 0.95 9.3 8.1 0.79 9.5 5.5 2.1 1 1 1 2 2 2 0 Nsp1-like C-terminal region DUF724 PF05266.14 EMC88064.1 - 0.98 9.2 9.5 1.7 8.4 9.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) V_ATPase_I PF01496.19 EMC88064.1 - 1.2 6.9 3.3 1.6 6.5 3.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spore_III_AB PF09548.10 EMC88064.1 - 1.4 9.0 4.9 2.1 8.4 4.9 1.2 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) NPV_P10 PF05531.12 EMC88064.1 - 1.6 9.3 5.7 4.1 7.9 3.7 2.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein PCRF PF03462.18 EMC88064.1 - 2.1 8.1 6.4 4.1 7.2 6.4 1.4 1 0 0 1 1 1 0 PCRF domain Atg14 PF10186.9 EMC88064.1 - 2.5 7.1 5.6 4 6.4 5.6 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DivIC PF04977.15 EMC88064.1 - 2.7 7.8 14.2 1.9 8.3 2.2 2.6 1 1 1 2 2 2 0 Septum formation initiator DUF4140 PF13600.6 EMC88064.1 - 3.1 8.3 7.9 29 5.2 7.3 2.4 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Laminin_II PF06009.12 EMC88064.1 - 3.7 7.6 8.3 9.9 6.2 5.6 2.2 2 0 0 2 2 2 0 Laminin Domain II Prefoldin PF02996.17 EMC88064.1 - 5.1 7.0 10.3 5 7.1 2.3 2.3 1 1 1 2 2 2 0 Prefoldin subunit BRE1 PF08647.11 EMC88064.1 - 5.7 7.1 17.7 3.1 7.9 13.9 2.0 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Prefoldin_2 PF01920.20 EMC88064.1 - 6.7 6.7 15.0 5.5 7.0 2.8 2.4 1 1 1 2 2 2 0 Prefoldin subunit TMF_DNA_bd PF12329.8 EMC88064.1 - 7.8 6.6 18.1 9.9 6.2 15.8 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding PH_TFIIH PF08567.11 EMC88065.1 - 4.9e-25 87.7 0.0 9.2e-25 86.8 0.0 1.4 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain BSD PF03909.17 EMC88065.1 - 1.2e-22 79.7 5.1 1.2e-16 60.5 0.0 3.4 4 0 0 4 4 4 2 BSD domain SAA PF00277.18 EMC88067.1 - 4e-43 146.0 4.8 4.8e-43 145.8 4.8 1.1 1 0 0 1 1 1 1 Serum amyloid A protein IKKbetaNEMObind PF12179.8 EMC88068.1 - 0.2 11.7 1.6 0.38 10.8 0.6 2.0 2 0 0 2 2 2 0 I-kappa-kinase-beta NEMO binding domain Biopterin_H PF00351.21 EMC88069.1 - 1.8e-177 589.3 0.0 2.3e-177 589.0 0.0 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.25 EMC88069.1 - 1.2e-06 28.2 0.1 3.2e-06 26.8 0.0 1.9 2 0 0 2 2 2 1 ACT domain DUF5370 PF17340.2 EMC88069.1 - 0.033 14.1 0.0 0.087 12.7 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5370) Seryl_tRNA_N PF02403.22 EMC88069.1 - 0.29 11.4 1.5 10 6.4 0.3 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ACT_4 PF13291.6 EMC88069.1 - 0.47 11.1 2.4 0.45 11.1 0.3 2.0 2 0 0 2 2 2 0 ACT domain RCC1 PF00415.18 EMC88070.1 - 2.7e-54 181.6 22.4 4.5e-10 40.0 0.0 7.3 7 1 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EMC88070.1 - 3.1e-31 106.5 42.8 8.6e-10 38.2 2.1 8.0 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat Ion_trans PF00520.31 EMC88071.1 - 8.2e-45 152.9 12.8 1e-44 152.6 12.8 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 EMC88071.1 - 6.8e-28 96.9 0.0 1.7e-27 95.6 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 EMC88071.1 - 2.7e-11 43.3 2.6 2.7e-11 43.3 2.6 2.5 2 0 0 2 2 2 1 Ion channel BTB_3 PF16017.5 EMC88071.1 - 0.0029 17.7 0.0 0.0068 16.5 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain VWD PF00094.25 EMC88073.1 - 1.1e-80 269.5 8.5 6.5e-36 124.0 0.1 3.7 3 0 0 3 3 3 3 von Willebrand factor type D domain C8 PF08742.11 EMC88073.1 - 8.6e-43 144.6 56.8 4.9e-17 62.1 3.4 9.8 8 2 0 8 8 8 4 C8 domain TIL PF01826.17 EMC88073.1 - 4.8e-13 49.1 80.8 1.7e-10 41.0 19.9 17.1 15 3 4 19 19 19 5 Trypsin Inhibitor like cysteine rich domain AbfB PF05270.13 EMC88073.1 - 5.8e-09 36.1 0.1 1.4e-08 34.8 0.1 1.6 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B (ABFB) domain VWC PF00093.18 EMC88073.1 - 0.0049 17.2 3.8 0.0049 17.2 3.8 17.9 12 3 5 18 18 18 4 von Willebrand factor type C domain ABC_membrane PF00664.23 EMC88074.1 - 1.6e-75 254.3 39.6 4e-41 141.5 6.1 2.8 3 0 0 3 3 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EMC88074.1 - 4.1e-50 169.9 2.3 2.2e-24 86.5 0.0 3.7 4 0 0 4 4 4 2 ABC transporter SMC_N PF02463.19 EMC88074.1 - 1.4e-10 41.0 1.7 0.0014 18.2 0.0 3.5 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EMC88074.1 - 1.2e-05 25.3 1.5 1.2 8.9 0.2 3.9 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EMC88074.1 - 0.0003 20.5 0.6 0.19 11.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EMC88074.1 - 0.00044 20.2 0.0 0.033 14.1 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase ABC_ATPase PF09818.9 EMC88074.1 - 0.00063 18.7 1.1 0.11 11.2 0.0 3.0 3 1 0 3 3 3 1 Predicted ATPase of the ABC class AAA_25 PF13481.6 EMC88074.1 - 0.0022 17.6 0.0 0.12 11.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EMC88074.1 - 0.0023 18.0 0.2 0.83 9.8 0.1 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.6 EMC88074.1 - 0.0041 17.6 4.7 0.48 10.9 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_15 PF13175.6 EMC88074.1 - 0.0067 16.2 0.0 0.3 10.8 0.0 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EMC88074.1 - 0.016 15.4 0.5 4.2 7.7 0.0 3.0 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EMC88074.1 - 0.035 13.6 0.0 2.6 7.5 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region ATPase PF06745.13 EMC88074.1 - 0.053 12.9 0.2 8.8 5.6 0.0 2.5 2 0 0 2 2 2 0 KaiC ATP-synt_ab PF00006.25 EMC88074.1 - 0.056 13.1 0.0 1.1 8.9 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain T2SSE PF00437.20 EMC88074.1 - 0.079 12.0 0.0 3.1 6.8 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein Zeta_toxin PF06414.12 EMC88074.1 - 0.092 12.0 0.1 0.61 9.3 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin AAA_16 PF13191.6 EMC88074.1 - 0.1 12.9 0.0 0.97 9.8 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 EMC88074.1 - 0.11 12.2 0.6 0.52 10.0 0.1 2.3 2 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EMC88074.1 - 0.12 12.1 0.0 4 7.1 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain Dynamin_N PF00350.23 EMC88074.1 - 6.5 6.8 8.6 1 9.4 0.1 2.9 3 0 0 3 3 3 0 Dynamin family IRK_C PF17655.1 EMC88075.1 - 5.6e-69 231.2 0.0 7.2e-69 230.9 0.0 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 EMC88075.1 - 1.3e-52 177.3 0.1 2.2e-52 176.6 0.1 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain EI24 PF07264.11 EMC88075.1 - 0.05 13.9 2.2 0.073 13.3 2.2 1.2 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Ion_trans_2 PF07885.16 EMC88075.1 - 0.63 10.0 6.5 2.4 8.2 6.5 2.0 1 1 0 1 1 1 0 Ion channel EF-hand_7 PF13499.6 EMC88076.1 - 2e-11 44.2 3.4 2e-11 44.2 3.4 4.2 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 EMC88076.1 - 8.9e-09 34.3 5.2 0.00021 20.6 0.4 3.8 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 EMC88076.1 - 2.4e-07 30.1 3.1 1.3e-05 24.7 0.2 3.5 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.6 EMC88076.1 - 0.00034 20.0 3.6 0.0096 15.4 0.4 4.3 4 0 0 4 4 4 1 EF hand Histone_HNS PF00816.21 EMC88076.1 - 0.037 14.8 0.5 0.037 14.8 0.5 3.7 3 1 1 4 4 4 0 H-NS histone family EF-hand_8 PF13833.6 EMC88076.1 - 0.81 9.6 5.2 2.9 7.8 0.0 3.6 4 0 0 4 4 4 0 EF-hand domain pair MctB PF11382.8 EMC88076.1 - 2.9 7.5 9.2 5.9 6.5 9.2 1.4 1 0 0 1 1 1 0 Copper transport outer membrane protein, MctB SlyX PF04102.12 EMC88076.1 - 5.4 7.7 18.9 1.2 9.8 12.9 3.1 2 1 0 2 2 2 0 SlyX Ribosomal_S13_N PF08069.12 EMC88077.1 - 8e-20 70.7 0.1 9.1e-20 70.5 0.1 1.0 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain HTH_38 PF13936.6 EMC88077.1 - 0.053 13.3 0.0 0.087 12.6 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain PH PF00169.29 EMC88078.1 - 2.2e-19 69.9 0.0 7.2e-19 68.3 0.0 1.9 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EMC88078.1 - 9.3e-09 35.7 1.0 4.5e-08 33.5 0.1 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 EMC88078.1 - 2.8e-05 24.3 0.0 0.028 14.7 0.0 2.9 1 1 0 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.6 EMC88078.1 - 0.0053 17.1 2.4 0.017 15.4 0.0 3.0 3 0 0 3 3 3 1 Pleckstrin homology domain PH_3 PF14593.6 EMC88078.1 - 0.011 15.9 0.0 0.29 11.3 0.0 2.9 1 1 0 1 1 1 0 PH domain HMG_box_5 PF14887.6 EMC88078.1 - 0.038 13.9 2.7 0.11 12.5 0.7 2.6 2 0 0 2 2 2 0 HMG (high mobility group) box 5 DUF3947 PF13135.6 EMC88078.1 - 1.1 9.6 3.4 1.2 9.4 1.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3947) SMAP PF15477.6 EMC88079.1 - 0.00026 21.9 0.6 0.00026 21.9 0.6 2.3 2 1 0 2 2 2 1 Small acidic protein family PNISR PF15996.5 EMC88079.1 - 0.22 11.8 14.1 0.25 11.6 14.1 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Paf1 PF03985.13 EMC88079.1 - 0.43 9.5 18.2 0.48 9.4 18.2 1.0 1 0 0 1 1 1 0 Paf1 Spore_coat_CotO PF14153.6 EMC88079.1 - 0.52 10.2 11.3 0.66 9.9 11.3 1.1 1 0 0 1 1 1 0 Spore coat protein CotO SH3-WW_linker PF16618.5 EMC88079.1 - 0.59 10.6 13.3 0.74 10.2 13.3 1.2 1 0 0 1 1 1 0 Linker region between SH3 and WW domains on ARHGAP12 RNA_polI_A34 PF08208.11 EMC88079.1 - 0.68 10.0 11.9 0.94 9.5 11.9 1.2 1 1 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Nop14 PF04147.12 EMC88079.1 - 1.3 7.1 16.4 1.5 6.9 16.4 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EMC88079.1 - 1.4 7.1 13.8 1.6 6.9 13.8 1.0 1 0 0 1 1 1 0 CDC45-like protein DDHD PF02862.17 EMC88079.1 - 1.8 8.6 7.1 2.2 8.4 7.1 1.1 1 0 0 1 1 1 0 DDHD domain Herpes_DNAp_acc PF04929.12 EMC88079.1 - 2.9 6.8 5.9 3.3 6.6 5.9 1.0 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Presenilin PF01080.17 EMC88079.1 - 8.2 5.1 11.5 9.6 4.8 11.5 1.1 1 0 0 1 1 1 0 Presenilin HMG_box PF00505.19 EMC88080.1 - 1.5e-22 79.8 4.5 5.5e-22 78.0 4.5 2.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC88080.1 - 2e-09 37.9 1.1 2e-09 37.9 1.1 3.4 3 0 0 3 3 3 1 HMG-box domain AAA_23 PF13476.6 EMC88080.1 - 0.77 10.2 14.5 9.9 6.6 13.6 2.5 2 0 0 2 2 2 0 AAA domain MPS2 PF17060.5 EMC88080.1 - 1.2 8.4 17.2 0.052 12.8 11.5 1.6 2 0 0 2 2 2 0 Monopolar spindle protein 2 DivIVA PF05103.13 EMC88080.1 - 6.1 6.9 19.2 6.8 6.8 14.2 2.4 2 0 0 2 2 2 0 DivIVA protein INSC_LBD PF16748.5 EMC88081.1 - 2.5e-27 94.0 4.8 5.5e-27 93.0 4.8 1.5 1 0 0 1 1 1 1 Inscuteable LGN-binding domain Arm PF00514.23 EMC88081.1 - 0.0069 16.4 0.3 0.0069 16.4 0.3 5.1 5 1 0 5 5 5 2 Armadillo/beta-catenin-like repeat SPOB_ab PF14682.6 EMC88081.1 - 0.31 11.1 9.5 0.29 11.2 2.7 3.0 2 1 1 3 3 3 0 Sporulation initiation phospho-transferase B, C-terminal CMS1 PF14617.6 EMC88081.1 - 0.32 10.3 3.4 2.7 7.3 0.0 3.3 4 0 0 4 4 4 0 U3-containing 90S pre-ribosomal complex subunit Calc_CGRP_IAPP PF00214.19 EMC88082.1 - 2.1e-29 102.3 0.1 2.4e-29 102.1 0.1 1.0 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family TA_inhibitor PF17574.2 EMC88082.1 - 0.11 12.5 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Inhibitor of toxin/antitoxin system (Gp4.5) p450 PF00067.22 EMC88083.1 - 6.5e-115 384.5 0.0 7.2e-115 384.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Proteasome PF00227.26 EMC88084.1 - 2.6e-47 160.8 0.0 3.3e-47 160.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EMC88084.1 - 1.7e-13 50.0 0.0 3.5e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Adaptin_N PF01602.20 EMC88085.1 - 9.4e-122 407.2 8.9 1.5e-121 406.5 8.9 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Coatamer_beta_C PF07718.12 EMC88085.1 - 7.9e-61 204.1 0.3 1.7e-60 203.0 0.3 1.6 1 0 0 1 1 1 1 Coatomer beta C-terminal region Coatomer_b_Cpla PF14806.6 EMC88085.1 - 3e-60 201.8 0.1 1.6e-59 199.5 0.0 2.2 2 0 0 2 2 2 1 Coatomer beta subunit appendage platform Cnd1 PF12717.7 EMC88085.1 - 3.1e-08 33.8 12.1 2.8e-05 24.2 0.1 4.2 2 1 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EMC88085.1 - 8.3e-08 32.5 4.0 0.034 14.5 0.0 6.0 5 2 3 8 8 8 3 HEAT repeats HEAT PF02985.22 EMC88085.1 - 9.3e-08 31.7 0.2 0.036 14.3 0.0 5.2 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 EMC88085.1 - 5.5e-06 26.8 0.4 1.1 9.8 0.0 5.1 5 0 0 5 5 5 2 HEAT-like repeat Arm PF00514.23 EMC88085.1 - 0.00023 21.1 0.1 1.8 8.7 0.0 4.1 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat MMS19_N PF14500.6 EMC88085.1 - 0.00036 20.2 2.1 0.0053 16.4 0.0 3.4 2 1 2 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II DUF5578 PF17741.1 EMC88085.1 - 0.0053 16.2 4.6 0.8 9.1 0.3 3.3 1 1 2 3 3 3 2 Family of unknown function (DUF5578) Ras PF00071.22 EMC88086.1 - 7.8e-48 162.1 0.3 8.9e-48 162.0 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC88086.1 - 9.2e-12 45.2 0.0 3.3e-11 43.5 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EMC88086.1 - 2.2e-06 27.3 0.0 2.7e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 EMC88086.1 - 8.1e-06 25.4 0.1 9.1e-06 25.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family ATP_bind_1 PF03029.17 EMC88086.1 - 0.0086 15.9 0.1 0.01 15.7 0.1 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein Tub PF01167.18 EMC88087.1 - 9.3e-96 320.2 1.3 1.2e-95 319.9 0.0 1.8 2 1 0 2 2 2 1 Tub family Tub_N PF16322.5 EMC88087.1 - 1.9e-63 214.7 26.7 2.7e-63 214.2 26.7 1.2 1 0 0 1 1 1 1 Tubby N-terminal UpxZ PF06603.11 EMC88087.1 - 0.074 13.4 1.0 5.6 7.3 0.1 2.9 2 2 0 2 2 2 0 UpxZ family of transcription anti-terminator antagonists RIC3 PF15361.6 EMC88088.1 - 4.1e-32 111.6 0.0 1e-31 110.3 0.0 1.7 1 0 0 1 1 1 1 Resistance to inhibitors of cholinesterase homologue 3 KIP1 PF07765.12 EMC88088.1 - 7.5 6.8 6.3 1.1 9.4 1.8 1.9 2 0 0 2 2 2 0 KIP1-like protein LIM PF00412.22 EMC88089.1 - 2.6e-30 104.4 21.9 4e-15 55.8 8.1 2.1 2 0 0 2 2 2 2 LIM domain Ribosomal_L27A PF00828.19 EMC88090.1 - 2.9e-25 89.4 0.0 3.9e-25 89.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A DENN PF02141.21 EMC88091.1 - 1.8e-58 197.6 0.7 1.8e-58 197.6 0.7 2.0 2 0 0 2 2 2 1 DENN (AEX-3) domain uDENN PF03456.18 EMC88091.1 - 7.9e-17 61.8 0.1 2.3e-16 60.3 0.1 1.9 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 EMC88091.1 - 2.3e-12 46.7 3.2 6.7e-12 45.2 3.2 1.9 1 0 0 1 1 1 1 dDENN domain CarboxypepD_reg PF13620.6 EMC88092.1 - 0.00027 21.1 0.4 0.00041 20.6 0.4 1.5 1 1 0 1 1 1 1 Carboxypeptidase regulatory-like domain fn3_3 PF14686.6 EMC88092.1 - 0.023 14.5 0.1 0.038 13.8 0.1 1.5 1 0 0 1 1 1 0 Polysaccharide lyase family 4, domain II Tad_C PF09977.9 EMC88092.1 - 0.038 15.2 0.3 0.049 14.9 0.3 1.2 1 0 0 1 1 1 0 Putative Tad-like Flp pilus-assembly DUF4537 PF15057.6 EMC88093.1 - 3.5e-29 101.3 0.0 4.8e-29 100.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) Tudor_3 PF18115.1 EMC88093.1 - 0.1 12.5 0.0 11 6.0 0.0 2.5 2 1 0 2 2 2 0 DNA repair protein Crb2 Tudor domain Tmemb_9 PF05434.11 EMC88094.1 - 1.9e-49 167.3 0.2 2.4e-49 167.0 0.2 1.1 1 0 0 1 1 1 1 TMEM9 Asp_protease PF09668.10 EMC88095.1 - 2.6e-10 40.2 0.0 4.7e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 EMC88095.1 - 4.6e-09 36.7 0.0 9.4e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EMC88095.1 - 2.5e-06 28.1 0.0 6.9e-06 26.6 0.0 1.8 1 1 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.11 EMC88095.1 - 0.13 12.1 0.0 0.19 11.5 0.0 1.4 1 1 0 1 1 1 0 Retroviral aspartyl protease DENN PF02141.21 EMC88096.1 - 4.2e-61 206.1 5.4 6.2e-61 205.6 4.4 1.8 2 0 0 2 2 2 1 DENN (AEX-3) domain RUN PF02759.19 EMC88096.1 - 1.1e-27 96.6 3.1 1.2e-13 51.1 0.0 2.8 2 0 0 2 2 2 2 RUN domain dDENN PF03455.19 EMC88096.1 - 1.9e-19 69.4 1.9 1.9e-19 69.4 1.9 3.0 3 0 0 3 3 3 1 dDENN domain uDENN PF03456.18 EMC88096.1 - 3.3e-15 56.6 0.6 9.1e-15 55.2 0.0 2.2 2 0 0 2 2 2 1 uDENN domain PLAT PF01477.23 EMC88096.1 - 9.2e-15 55.2 0.0 2.7e-14 53.7 0.0 1.8 2 0 0 2 2 2 1 PLAT/LH2 domain SNARE_assoc PF09335.11 EMC88097.1 - 3.2e-22 79.2 6.1 3.2e-22 79.2 6.1 2.6 3 0 0 3 3 3 1 SNARE associated Golgi protein DUF5305 PF17231.2 EMC88097.1 - 0.032 13.6 0.3 0.18 11.2 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5305) Oleosin PF01277.17 EMC88097.1 - 0.2 11.4 3.7 0.28 11.0 0.0 2.8 2 1 1 3 3 3 0 Oleosin TMEM208_SND2 PF05620.11 EMC88097.1 - 1.5 8.6 6.5 1.4 8.7 0.8 2.7 2 1 1 3 3 3 0 SRP-independent targeting protein 2/TMEM208 zf-H2C2_2 PF13465.6 EMC88098.1 - 9.2e-36 120.7 49.8 9.4e-08 32.2 0.5 7.7 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.26 EMC88098.1 - 3.1e-30 102.9 47.6 2.3e-06 27.7 1.2 7.4 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC88098.1 - 2.6e-19 68.2 43.6 0.0029 18.3 0.6 7.5 7 0 0 7 7 7 7 C2H2-type zinc finger CopK PF11525.8 EMC88098.1 - 6.1e-07 29.0 3.6 1.6 8.4 0.0 6.0 4 2 2 6 6 6 2 Copper resistance protein K zf-C2H2_8 PF15909.5 EMC88098.1 - 3.2e-06 27.3 16.3 0.017 15.4 4.7 3.5 1 1 3 4 4 4 4 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 EMC88098.1 - 3.5e-05 24.0 16.7 1.2 9.5 0.5 6.6 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-C2H2_aberr PF17017.5 EMC88098.1 - 5e-05 23.5 24.7 0.097 12.8 0.4 6.2 1 1 6 7 7 7 3 Aberrant zinc-finger FOXP-CC PF16159.5 EMC88098.1 - 0.00013 22.6 14.8 0.28 11.8 0.8 7.0 3 2 4 7 7 7 1 FOXP coiled-coil domain FecR PF04773.13 EMC88098.1 - 0.0052 17.4 3.7 0.33 11.6 0.1 4.0 2 1 1 3 3 3 1 FecR protein zf-TRAF PF02176.18 EMC88098.1 - 0.019 15.6 1.4 0.019 15.6 1.4 3.8 2 2 2 4 4 4 0 TRAF-type zinc finger Pkinase PF00069.25 EMC88099.1 - 1.3e-61 208.2 0.0 1.9e-61 207.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC88099.1 - 1e-26 93.8 0.0 1.4e-26 93.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 EMC88100.1 - 3.1e-18 66.2 1.2 7.3e-18 65.0 1.2 1.7 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 EMC88100.1 - 9.4e-05 22.6 0.1 0.0003 21.0 0.1 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EMC88100.1 - 0.0014 19.0 5.3 0.0014 19.0 5.3 3.4 3 2 0 3 3 3 1 Pleckstrin homology domain PH_2 PF08458.10 EMC88100.1 - 0.033 14.5 0.1 0.033 14.5 0.1 2.9 2 1 1 3 3 3 0 Plant pleckstrin homology-like region Calc_CGRP_IAPP PF00214.19 EMC88101.1 - 1.1e-30 106.5 0.0 1.3e-30 106.2 0.0 1.1 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family zf-C3HC4_3 PF13920.6 EMC88102.1 - 1.4e-10 40.8 10.7 2.4e-10 40.1 10.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC88102.1 - 2.6e-09 37.2 14.2 4.9e-09 36.4 14.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC88102.1 - 4.6e-09 36.0 13.4 8.2e-09 35.2 13.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC88102.1 - 4.3e-07 29.7 10.9 9.6e-07 28.6 10.9 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EMC88102.1 - 1.3e-06 28.1 12.5 2.6e-06 27.2 12.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC88102.1 - 1.2e-05 25.3 11.5 2.6e-05 24.1 11.5 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMC88102.1 - 0.00022 21.1 14.5 0.0021 18.0 14.2 2.2 1 1 1 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.7 EMC88102.1 - 0.0005 20.3 13.1 0.0014 18.9 13.1 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EMC88102.1 - 0.03 14.5 12.3 0.058 13.6 11.5 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Gp138_N PF18352.1 EMC88102.1 - 0.053 13.6 0.1 2.3 8.4 0.1 2.4 2 0 0 2 2 2 0 Phage protein Gp138 N-terminal domain Sulfotransfer_2 PF03567.14 EMC88102.1 - 0.065 13.1 0.1 0.12 12.3 0.0 1.5 2 0 0 2 2 2 0 Sulfotransferase family zf-RING_4 PF14570.6 EMC88102.1 - 0.24 11.2 11.9 0.52 10.2 11.9 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 EMC88102.1 - 0.48 10.5 9.3 0.99 9.5 8.5 1.8 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 EMC88102.1 - 4.2 7.2 16.1 2.5 7.9 12.9 2.3 2 1 0 2 2 2 0 RING-like zinc finger Xlink PF00193.17 EMC88103.1 - 2.4e-21 75.9 0.2 5.1e-21 74.9 0.2 1.6 1 0 0 1 1 1 1 Extracellular link domain DUF4834 PF16118.5 EMC88103.1 - 0.0041 18.0 0.0 0.0092 16.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) OSTbeta PF15048.6 EMC88103.1 - 0.05 13.7 0.2 0.19 11.8 0.1 1.9 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein Nucleoside_tran PF01733.18 EMC88103.1 - 0.054 12.9 0.2 0.084 12.2 0.2 1.2 1 0 0 1 1 1 0 Nucleoside transporter vMSA PF00695.19 EMC88103.1 - 0.055 12.6 0.1 0.071 12.2 0.1 1.2 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus Comm PF15957.5 EMC88103.1 - 0.091 13.1 2.4 0.24 11.8 0.1 2.3 1 1 0 2 2 2 0 Commissureless DUF4446 PF14584.6 EMC88103.1 - 0.14 12.1 0.1 0.25 11.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Phage_holin_3_6 PF07332.11 EMC88103.1 - 0.14 12.2 0.2 0.32 11.0 0.0 1.6 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III MRVI1 PF05781.12 EMC88104.1 - 1.2e-219 730.5 14.6 1.6e-219 730.1 14.6 1.2 1 0 0 1 1 1 1 MRVI1 protein PEP-utilisers_N PF05524.13 EMC88104.1 - 0.57 10.4 4.5 1.3 9.2 2.7 2.5 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal MIF4G PF02854.19 EMC88105.1 - 9.7e-58 195.3 1.5 9.7e-58 195.3 1.5 2.3 2 0 0 2 2 2 1 MIF4G domain W2 PF02020.18 EMC88105.1 - 1.1e-20 73.5 1.6 3.4e-20 71.9 1.0 2.3 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon MA3 PF02847.17 EMC88105.1 - 1.8e-10 40.8 0.2 1.8e-10 40.8 0.2 3.0 3 0 0 3 3 3 1 MA3 domain Glycos_transf_2 PF00535.26 EMC88106.1 - 1.5e-24 86.7 0.0 2.2e-24 86.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 EMC88106.1 - 5.1e-16 59.1 1.3 9.2e-16 58.2 1.3 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 EMC88106.1 - 0.00038 20.1 0.0 0.0012 18.4 0.0 1.9 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase UCH PF00443.29 EMC88107.1 - 2.4e-49 168.2 0.7 5.3e-49 167.0 0.7 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMC88107.1 - 1.4e-38 133.3 1.2 3.4e-38 132.0 1.2 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_2 PF14560.6 EMC88107.1 - 3e-08 34.0 0.1 0.13 12.7 0.0 4.0 3 0 0 3 3 3 3 Ubiquitin-like domain ubiquitin PF00240.23 EMC88107.1 - 4.2e-07 29.6 0.2 0.17 11.7 0.0 4.0 3 0 0 3 3 3 2 Ubiquitin family Sad1_UNC PF07738.13 EMC88107.1 - 0.019 15.0 0.0 0.052 13.6 0.0 1.7 1 0 0 1 1 1 0 Sad1 / UNC-like C-terminal DUF4487 PF14868.6 EMC88107.1 - 0.024 13.5 0.2 0.044 12.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4487) UN_NPL4 PF11543.8 EMC88107.1 - 0.077 13.5 0.2 22 5.6 0.0 3.5 3 0 0 3 3 3 0 Nuclear pore localisation protein NPL4 Dickkopf_N PF04706.12 EMC88108.1 - 1e-15 57.9 19.9 1e-15 57.9 19.9 3.1 3 0 0 3 3 3 2 Dickkopf N-terminal cysteine-rich region Prokineticin PF06607.11 EMC88108.1 - 4.7e-05 23.6 5.4 4.7e-05 23.6 5.4 2.7 1 1 2 3 3 3 1 Prokineticin CH PF00307.31 EMC88109.1 - 1.1e-22 80.3 0.0 2.8e-22 79.0 0.0 1.8 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EMC88109.1 - 3.8e-13 49.1 0.0 9.1e-13 47.9 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain LIM PF00412.22 EMC88109.1 - 1e-08 35.3 10.4 2.4e-08 34.1 10.4 1.7 1 0 0 1 1 1 1 LIM domain FAD_binding_3 PF01494.19 EMC88109.1 - 3.8e-07 29.7 0.0 1.3e-06 27.9 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EMC88109.1 - 1.3e-05 24.6 0.0 2.6e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMC88109.1 - 3.1e-05 23.4 0.0 6e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMC88109.1 - 0.00011 21.4 0.0 0.00016 20.9 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EMC88109.1 - 0.00049 20.6 0.1 0.0017 18.9 0.1 2.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMC88109.1 - 0.00053 18.8 0.0 0.00092 18.0 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_7 PF13241.6 EMC88109.1 - 0.00064 20.1 0.0 0.0016 18.8 0.0 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding DAO PF01266.24 EMC88109.1 - 0.0012 18.5 0.0 0.0032 17.1 0.0 1.7 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMC88109.1 - 0.0033 17.6 0.0 0.0073 16.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EMC88109.1 - 0.016 14.6 0.0 0.04 13.3 0.0 1.7 1 0 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EMC88109.1 - 0.022 13.8 0.0 0.049 12.7 0.0 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.17 EMC88109.1 - 0.065 12.5 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Thi4 family AlaDh_PNT_C PF01262.21 EMC88109.1 - 0.087 12.1 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EMC88109.1 - 0.096 11.7 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A DUF3585 PF12130.8 EMC88110.1 - 1.5e-38 132.0 26.6 1.5e-38 132.0 26.6 2.2 2 0 0 2 2 2 1 Bivalent Mical/EHBP Rab binding domain CH PF00307.31 EMC88111.1 - 3e-19 69.2 1.3 4.1e-19 68.8 1.3 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EMC88111.1 - 0.011 15.5 0.0 0.026 14.4 0.0 1.6 1 0 0 1 1 1 0 CAMSAP CH domain FlaG PF03646.15 EMC88111.1 - 0.021 15.0 0.6 0.047 13.9 0.6 1.5 1 0 0 1 1 1 0 FlaG protein Sfi1 PF08457.10 EMC88111.1 - 0.067 11.7 0.1 0.079 11.5 0.1 1.1 1 0 0 1 1 1 0 Sfi1 spindle body protein DUF957 PF06117.11 EMC88111.1 - 0.069 12.7 0.1 0.15 11.6 0.1 1.6 1 0 0 1 1 1 0 Enterobacterial protein of unknown function (DUF957) CH PF00307.31 EMC88112.1 - 1.3e-06 28.6 0.0 1.4e-06 28.5 0.0 1.0 1 0 0 1 1 1 1 Calponin homology (CH) domain YBD PF17725.1 EMC88113.1 - 7.5e-100 333.0 1.2 1e-99 332.6 1.2 1.2 1 0 0 1 1 1 1 YAP binding domain TEA PF01285.18 EMC88113.1 - 2.1e-27 95.0 0.0 4.3e-27 94.0 0.0 1.5 1 0 0 1 1 1 1 TEA/ATTS domain PAS_11 PF14598.6 EMC88114.1 - 1.2e-26 93.1 0.4 9.3e-23 80.5 0.2 2.3 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 EMC88114.1 - 5.7e-21 74.6 0.0 2.8e-09 37.0 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_3 PF08447.12 EMC88114.1 - 6.5e-20 71.2 0.0 8.5e-12 45.2 0.0 2.4 2 0 0 2 2 2 2 PAS fold HLH PF00010.26 EMC88114.1 - 2.5e-16 59.3 0.8 4.4e-16 58.6 0.8 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.7 EMC88114.1 - 1.9e-08 34.5 0.0 7.9e-05 22.9 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 EMC88114.1 - 2.9e-05 24.3 0.0 0.01 16.1 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_2 PF08446.11 EMC88114.1 - 0.025 15.2 0.0 0.091 13.4 0.0 1.8 2 0 0 2 2 2 0 PAS fold BTB_3 PF16017.5 EMC88115.1 - 1.3e-50 169.9 0.0 2.3e-50 169.1 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB_2 PF02214.22 EMC88115.1 - 0.00055 20.2 0.0 0.0015 18.8 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain Parathyroid PF01279.17 EMC88116.1 - 1.1e-07 32.5 1.7 1.3e-07 32.2 1.7 1.2 1 0 0 1 1 1 1 Parathyroid hormone family NAD_binding_4 PF07993.12 EMC88117.1 - 2.2e-78 263.0 0.0 2.8e-78 262.6 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein Sterile PF03015.19 EMC88117.1 - 3.9e-31 107.1 2.0 9.2e-31 105.9 2.0 1.7 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 EMC88117.1 - 7.7e-09 35.4 0.0 9e-08 31.9 0.0 2.2 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EMC88117.1 - 4.1e-05 22.7 0.0 0.033 13.2 0.1 3.0 2 1 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EMC88117.1 - 0.00023 20.7 0.0 0.00044 19.7 0.0 1.5 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Semialdhyde_dh PF01118.24 EMC88117.1 - 0.00027 21.4 0.0 0.00049 20.5 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 EMC88117.1 - 0.00037 19.7 0.0 0.00097 18.4 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 EMC88117.1 - 0.059 13.3 0.0 0.17 11.8 0.0 1.7 1 1 0 1 1 1 0 KR domain Trypsin PF00089.26 EMC88118.1 - 2e-66 224.0 0.0 2.3e-66 223.8 0.0 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 EMC88118.1 - 3.8e-08 33.7 0.0 8.1e-08 32.7 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 EMC88118.1 - 2.8e-06 28.3 0.0 9e-06 26.7 0.0 2.0 1 1 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EMC88119.1 - 2e-73 246.9 0.1 2.3e-73 246.7 0.1 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 EMC88119.1 - 4.6e-11 43.1 0.6 7.9e-11 42.4 0.6 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 EMC88119.1 - 3.8e-06 27.9 0.0 9.6e-06 26.6 0.0 1.7 1 1 0 1 1 1 1 Trypsin-like peptidase domain SAM_1 PF00536.30 EMC88120.1 - 1.8e-41 140.4 5.8 8.2e-19 67.8 0.0 4.4 4 0 0 4 4 4 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMC88120.1 - 2.2e-39 133.4 3.4 4.4e-15 55.5 0.0 4.0 4 0 0 4 4 4 3 SAM domain (Sterile alpha motif) Myosin_tail_1 PF01576.19 EMC88120.1 - 6.6e-05 20.9 26.6 0.0001 20.3 26.6 1.2 1 0 0 1 1 1 1 Myosin tail DUF16 PF01519.16 EMC88120.1 - 0.023 15.2 1.8 0.023 15.2 1.8 3.4 3 0 0 3 3 3 0 Protein of unknown function DUF16 DUF1192 PF06698.11 EMC88120.1 - 0.06 13.4 3.2 1.8 8.7 1.7 3.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1192) TTKRSYEDQ PF10212.9 EMC88120.1 - 0.28 10.1 21.3 0.44 9.5 21.3 1.2 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein SAM_PNT PF02198.16 EMC88120.1 - 0.33 11.0 3.4 8.7 6.4 0.1 3.3 3 0 0 3 3 3 0 Sterile alpha motif (SAM)/Pointed domain HMMR_N PF15905.5 EMC88120.1 - 0.52 9.7 36.7 0.04 13.4 8.3 2.4 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal ADIP PF11559.8 EMC88120.1 - 0.55 10.3 28.8 1.5 8.9 16.5 3.3 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding OLF PF02191.16 EMC88121.1 - 1e-77 261.0 0.0 1.3e-77 260.7 0.0 1.1 1 0 0 1 1 1 1 Olfactomedin-like domain DUF1088 PF06469.11 EMC88121.1 - 0.088 12.5 0.1 0.16 11.6 0.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1088) C2 PF00168.30 EMC88122.1 - 5.7e-53 177.5 0.1 7.7e-26 90.4 0.1 2.3 2 0 0 2 2 2 2 C2 domain PI3K_C2 PF00792.24 EMC88122.1 - 0.0026 17.7 0.1 1.7 8.5 0.0 3.0 3 0 0 3 3 3 2 Phosphoinositide 3-kinase C2 CEP76-C2 PF15627.6 EMC88122.1 - 0.033 13.7 0.0 4.7 6.8 0.0 2.3 2 0 0 2 2 2 0 CEP76 C2 domain TSP_1 PF00090.19 EMC88123.1 - 9.3e-86 281.9 85.0 9.5e-17 61.0 5.8 6.7 6 0 0 6 6 6 6 Thrombospondin type 1 domain Spond_N PF06468.13 EMC88123.1 - 1.2e-71 240.9 0.1 2.4e-71 239.8 0.1 1.6 1 0 0 1 1 1 1 Spondin_N Reeler PF02014.16 EMC88123.1 - 9.9e-22 78.1 0.0 2e-21 77.1 0.0 1.6 1 0 0 1 1 1 1 Reeler domain RRN9 PF10680.9 EMC88123.1 - 2.9 8.3 5.3 11 6.3 1.2 2.9 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor DUF3827 PF12877.7 EMC88124.1 - 9e-292 969.5 7.4 9e-292 969.5 7.4 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3827) Pkinase PF00069.25 EMC88125.1 - 6.5e-48 163.4 0.0 1.4e-47 162.3 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC88125.1 - 5.8e-24 84.8 0.0 1.1e-23 83.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMC88125.1 - 6e-06 25.8 0.0 1.1e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMC88125.1 - 0.002 17.0 0.0 0.004 16.0 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMC88125.1 - 0.0066 16.4 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 EMC88125.1 - 0.088 12.4 0.1 0.16 11.5 0.1 1.4 1 0 0 1 1 1 0 RIO1 family Suf PF05843.14 EMC88126.1 - 1.5e-84 284.5 13.6 4.9e-83 279.5 0.3 5.1 4 2 1 5 5 5 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 EMC88126.1 - 4.6e-06 27.0 1.1 0.095 13.6 0.0 5.4 4 2 1 5 5 5 1 Tetratricopeptide repeat NRDE-2 PF08424.10 EMC88126.1 - 7.3e-06 25.3 13.3 0.24 10.5 0.1 5.7 3 2 4 7 7 7 5 NRDE-2, necessary for RNA interference TPR_6 PF13174.6 EMC88126.1 - 0.0017 18.9 3.3 0.085 13.5 0.1 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EMC88126.1 - 0.0063 17.0 1.7 0.11 13.1 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EMC88126.1 - 0.1 13.2 0.6 0.58 10.9 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat HAT PF02184.16 EMC88126.1 - 7.3 6.6 7.5 13 5.9 0.0 4.5 5 0 0 5 5 5 0 HAT (Half-A-TPR) repeat Tcp11 PF05794.13 EMC88127.1 - 1.4e-111 373.7 0.1 1.7e-111 373.5 0.1 1.1 1 0 0 1 1 1 1 T-complex protein 11 EF_TS PF00889.19 EMC88127.1 - 0.13 11.8 0.0 0.32 10.6 0.0 1.6 1 0 0 1 1 1 0 Elongation factor TS DEP PF00610.21 EMC88128.1 - 6.7e-17 61.3 1.7 9.2e-16 57.7 0.2 2.7 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF4211 PF13926.6 EMC88129.1 - 8.7e-22 77.7 0.0 4.3e-21 75.5 0.0 2.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4211) Gla PF00594.20 EMC88131.1 - 1.1e-19 70.3 5.9 1.1e-19 70.3 5.9 1.6 2 0 0 2 2 2 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain WBP-1 PF11669.8 EMC88131.1 - 0.0011 19.6 0.0 0.0027 18.3 0.0 1.7 2 0 0 2 2 2 1 WW domain-binding protein 1 Orthoreo_P10 PF07204.11 EMC88131.1 - 0.0026 17.7 0.3 0.0049 16.8 0.3 1.5 1 0 0 1 1 1 1 Orthoreovirus membrane fusion protein p10 CD34_antigen PF06365.12 EMC88131.1 - 0.0063 16.1 0.2 0.0096 15.5 0.2 1.2 1 0 0 1 1 1 1 CD34/Podocalyxin family EphA2_TM PF14575.6 EMC88131.1 - 0.01 16.7 0.0 0.025 15.4 0.0 1.7 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Adeno_E3_CR2 PF02439.15 EMC88131.1 - 0.044 13.5 4.0 0.08 12.7 4.0 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 TMEM154 PF15102.6 EMC88131.1 - 0.085 12.8 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family Comm PF15957.5 EMC88131.1 - 4.9 7.5 6.8 70 3.8 6.8 2.4 1 1 0 1 1 1 0 Commissureless CCDC73 PF15818.5 EMC88132.1 - 0 1210.4 90.0 0 1210.3 90.0 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 73 family DUF1664 PF07889.12 EMC88132.1 - 5.6 7.0 37.9 0.021 14.9 2.9 5.6 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) Mst1_SARAH PF11629.8 EMC88132.1 - 6.4 7.0 16.4 0.16 12.1 1.1 4.3 4 0 0 4 4 4 0 C terminal SARAH domain of Mst1 PCI PF01399.27 EMC88133.1 - 7e-15 55.4 1.7 4.6e-14 52.8 1.0 2.4 2 0 0 2 2 2 1 PCI domain eIF3m_C_helix PF18005.1 EMC88133.1 - 3.5e-12 45.8 2.9 6.7e-12 44.9 2.9 1.5 1 0 0 1 1 1 1 eIF3 subunit M, C-terminal helix WT1 PF02165.15 EMC88135.1 - 6.9e-134 445.7 14.5 1.5e-117 392.1 6.8 2.3 1 1 1 2 2 2 2 Wilm's tumour protein zf-C2H2 PF00096.26 EMC88135.1 - 4.5e-15 55.2 38.4 1.6e-05 25.1 3.1 4.9 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC88135.1 - 6.8e-14 51.6 39.1 5.7e-07 29.7 2.9 4.9 5 0 0 5 5 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC88135.1 - 1.9e-07 31.3 33.2 0.005 17.6 1.8 5.0 4 0 0 4 4 4 3 C2H2-type zinc finger FOXP-CC PF16159.5 EMC88135.1 - 0.00027 21.5 12.3 0.0047 17.5 0.5 3.9 2 1 2 4 4 4 2 FOXP coiled-coil domain zf-C2H2_aberr PF17017.5 EMC88135.1 - 0.0018 18.4 6.5 0.52 10.4 0.0 3.4 2 1 1 3 3 3 2 Aberrant zinc-finger zf-C2H2_8 PF15909.5 EMC88135.1 - 0.0045 17.2 12.6 0.048 14.0 3.0 2.9 1 1 2 3 3 3 1 C2H2-type zinc ribbon zf-met PF12874.7 EMC88135.1 - 0.04 14.3 2.0 0.04 14.3 2.0 4.7 5 0 0 5 5 5 0 Zinc-finger of C2H2 type C1-set PF07654.15 EMC88135.1 - 0.064 13.6 1.1 6.1 7.3 0.1 2.8 2 0 0 2 2 2 0 Immunoglobulin C1-set domain zf-C2H2_jaz PF12171.8 EMC88135.1 - 0.23 11.8 16.0 0.11 12.8 1.5 4.2 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_4 PF13717.6 EMC88135.1 - 3.1 7.8 8.1 35 4.4 0.0 3.7 4 0 0 4 4 4 0 zinc-ribbon domain CCAP PF11105.8 EMC88135.1 - 3.2 7.7 5.4 0.32 10.9 0.3 1.8 2 0 0 2 2 2 0 Arthropod cardioacceleratory peptide 2a MCM_OB PF17207.3 EMC88135.1 - 6.9 6.5 11.2 9.6 6.1 3.4 2.9 1 1 1 2 2 2 0 MCM OB domain EF-hand_1 PF00036.32 EMC88136.1 - 6.7e-18 62.8 17.0 0.0032 16.9 0.7 6.8 7 0 0 7 7 7 6 EF hand EF-hand_7 PF13499.6 EMC88136.1 - 2.7e-16 59.8 15.7 6.9e-07 29.6 0.5 4.3 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 EMC88136.1 - 3.1e-16 57.9 14.0 0.0068 16.3 0.0 6.5 6 0 0 6 6 6 5 EF-hand domain EF-hand_5 PF13202.6 EMC88136.1 - 2.1e-07 30.1 25.7 0.0024 17.3 0.9 6.5 6 1 0 6 6 6 3 EF hand EF-hand_8 PF13833.6 EMC88136.1 - 7.8e-05 22.5 17.9 0.21 11.4 0.3 6.3 5 2 2 7 7 7 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EMC88136.1 - 0.0012 19.2 9.5 0.51 10.7 0.2 3.4 3 1 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region Homez PF11569.8 EMC88136.1 - 0.44 10.1 2.8 5.1 6.7 0.2 2.9 3 0 0 3 3 3 0 Homeodomain leucine-zipper encoding, Homez EF-hand_4 PF12763.7 EMC88136.1 - 2.6 8.0 12.0 1.7 8.6 0.3 4.2 4 1 1 5 5 5 0 Cytoskeletal-regulatory complex EF hand VCBS PF13517.6 EMC88136.1 - 5.8 7.6 8.1 39 4.9 0.1 3.6 3 1 0 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella PAXNEB PF05625.11 EMC88137.1 - 9e-111 370.6 0.0 9.8e-111 370.5 0.0 1.0 1 0 0 1 1 1 1 PAXNEB protein Peptidase_S24 PF00717.23 EMC88138.1 - 7.8e-13 48.2 0.0 1.3e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 EMC88138.1 - 2.7e-07 30.5 0.0 0.00061 19.6 0.0 2.8 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 DnaJ PF00226.31 EMC88139.1 - 1.7e-17 63.3 0.4 2.4e-17 62.8 0.4 1.2 1 0 0 1 1 1 1 DnaJ domain zf-CSL PF05207.13 EMC88139.1 - 2.7e-12 46.2 6.8 4.7e-12 45.4 6.8 1.4 1 0 0 1 1 1 1 CSL zinc finger Metallophos PF00149.28 EMC88140.1 - 1.9e-11 44.9 0.8 2.8e-11 44.3 0.8 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EMC88140.1 - 0.0004 20.6 0.0 0.011 16.0 0.0 2.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain ARF7EP_C PF14949.6 EMC88141.1 - 2.4e-36 124.5 6.7 2.4e-36 124.5 6.7 1.8 2 0 0 2 2 2 1 ARF7 effector protein C-terminus Cys_knot PF00007.22 EMC88142.1 - 1.4e-30 105.6 17.2 1.8e-30 105.3 17.2 1.1 1 0 0 1 1 1 1 Cystine-knot domain Methyltransf_5 PF01795.19 EMC88143.1 - 5.1e-88 295.5 0.0 2.7e-87 293.2 0.0 1.8 1 1 0 1 1 1 1 MraW methylase family Methyltr_RsmB-F PF01189.17 EMC88143.1 - 3.6e-06 26.8 0.0 1e-05 25.3 0.0 1.7 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F Methyltransf_25 PF13649.6 EMC88143.1 - 0.0007 20.3 0.0 0.031 15.0 0.0 2.8 3 0 0 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMC88143.1 - 0.0027 17.1 0.0 2 7.7 0.0 2.2 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EMC88143.1 - 0.0055 16.5 0.0 1.7 8.4 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EMC88143.1 - 0.0088 16.7 0.1 0.64 10.7 0.0 2.9 3 0 0 3 3 3 1 Methyltransferase domain Met_10 PF02475.16 EMC88143.1 - 0.015 15.1 0.0 0.035 13.9 0.0 1.5 2 0 0 2 2 2 0 Met-10+ like-protein Methyltransf_15 PF09445.10 EMC88143.1 - 0.041 13.5 0.0 0.059 12.9 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase MTS PF05175.14 EMC88143.1 - 0.076 12.6 0.0 1.5 8.3 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_12 PF08242.12 EMC88143.1 - 0.089 13.5 0.0 2.1 9.2 0.0 2.7 3 0 0 3 3 3 0 Methyltransferase domain Kinesin PF00225.23 EMC88144.1 - 3.3e-115 384.6 0.6 3.3e-115 384.6 0.6 2.3 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EMC88144.1 - 1.6e-24 86.5 0.2 5.5e-24 84.8 0.2 1.9 1 0 0 1 1 1 1 Microtubule binding NGF PF00243.18 EMC88145.1 - 1.7e-46 157.1 2.4 2.2e-46 156.7 2.4 1.2 1 0 0 1 1 1 1 Nerve growth factor family Spaetzle PF16077.5 EMC88145.1 - 7.6e-05 23.2 0.9 0.00011 22.7 0.9 1.2 1 0 0 1 1 1 1 Spaetzle L27 PF02828.16 EMC88146.1 - 5.5e-23 80.5 0.3 1.3e-22 79.3 0.2 1.7 2 0 0 2 2 2 1 L27 domain PDZ PF00595.24 EMC88146.1 - 4.7e-21 74.9 0.6 6.9e-21 74.4 0.6 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC88146.1 - 1.3e-13 50.6 0.6 2.6e-13 49.6 0.2 1.7 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 EMC88146.1 - 0.0044 17.3 0.0 0.0073 16.6 0.0 1.3 1 0 0 1 1 1 1 PDZ domain His_Phos_2 PF00328.22 EMC88146.1 - 0.084 12.2 0.0 0.091 12.1 0.0 1.3 1 1 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) LRR_8 PF13855.6 EMC88147.1 - 8.3e-31 105.6 16.7 3.7e-15 55.4 2.2 4.5 2 1 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EMC88147.1 - 6.1e-18 64.6 13.5 8.3e-08 32.4 0.2 5.6 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC88147.1 - 2.9e-13 49.9 0.1 2.8e-07 30.5 0.2 2.9 2 1 1 3 3 3 2 BspA type Leucine rich repeat region (6 copies) 7tm_1 PF00001.21 EMC88147.1 - 2.1e-12 47.0 12.1 3.2e-12 46.3 12.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_9 PF14580.6 EMC88147.1 - 6.7e-07 29.0 0.5 1.6e-06 27.8 0.4 1.7 1 1 0 1 1 1 1 Leucine-rich repeat LRR_1 PF00560.33 EMC88147.1 - 8.2e-07 28.7 11.5 1.3 9.9 0.0 6.9 6 0 0 6 6 6 3 Leucine Rich Repeat LRR_6 PF13516.6 EMC88147.1 - 0.0034 17.3 20.2 0.25 11.5 0.2 5.8 6 0 0 6 6 6 3 Leucine Rich repeat DUF4207 PF13904.6 EMC88148.1 - 9.7e-36 123.7 41.9 1.3e-35 123.3 41.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4207) Presenilin PF01080.17 EMC88148.1 - 0.33 9.7 13.4 0.39 9.4 13.4 1.3 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 EMC88148.1 - 0.46 9.1 10.1 0.49 9.0 10.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TauD PF02668.16 EMC88149.1 - 4.1e-41 141.5 0.0 6.1e-41 141.0 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 EMC88149.1 - 1.2e-19 70.7 4.4 2.2e-15 57.1 0.8 2.9 2 1 1 3 3 3 2 Protein of unknown function (DUF971) CsiD PF08943.10 EMC88149.1 - 9.1e-05 21.7 0.0 0.00016 20.9 0.0 1.3 1 0 0 1 1 1 1 CsiD Raf1_N PF18578.1 EMC88149.1 - 0.033 14.7 0.0 0.065 13.7 0.0 1.5 1 0 0 1 1 1 0 Rubisco accumulation factor 1 alpha helical domain DSBA PF01323.20 EMC88149.1 - 0.14 11.9 0.2 0.47 10.2 0.1 1.9 2 0 0 2 2 2 0 DSBA-like thioredoxin domain Fibin PF15819.5 EMC88150.1 - 1.9e-78 262.6 0.0 2.1e-78 262.5 0.0 1.0 1 0 0 1 1 1 1 Fin bud initiation factor homologue SSF PF00474.17 EMC88151.1 - 1.7e-37 129.3 23.6 2.1e-37 128.9 23.6 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family NdhL PF10716.9 EMC88151.1 - 0.041 13.8 2.4 0.2 11.6 1.6 2.6 2 0 0 2 2 2 0 NADH dehydrogenase transmembrane subunit TPR_MLP1_2 PF07926.12 EMC88152.1 - 0.015 15.4 21.9 0.015 15.4 21.9 2.8 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein CALCOCO1 PF07888.11 EMC88152.1 - 0.038 12.9 32.4 0.058 12.3 32.4 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF2559 PF10832.8 EMC88152.1 - 0.041 14.0 2.1 0.11 12.6 0.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2559) CmlA_N PF18456.1 EMC88152.1 - 0.25 10.6 9.2 0.1 11.9 1.2 2.2 1 1 1 2 2 2 0 Diiron non-heme beta-hydroxylase N-terminal domain Leu_zip PF15294.6 EMC88152.1 - 0.28 10.6 33.8 0.03 13.8 9.0 2.0 1 1 1 2 2 2 0 Leucine zipper DUF1612 PF07756.12 EMC88152.1 - 0.54 10.5 8.4 20 5.5 2.9 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1612) DUF3584 PF12128.8 EMC88152.1 - 0.88 7.0 27.6 1.4 6.4 27.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Filament PF00038.21 EMC88152.1 - 1.4 8.5 30.4 1.4 8.5 16.6 2.6 1 1 2 3 3 3 0 Intermediate filament protein MAD PF05557.13 EMC88152.1 - 1.4 7.2 32.5 1.6 7.0 32.5 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein EzrA PF06160.12 EMC88152.1 - 1.7 6.7 27.4 0.071 11.3 3.1 2.9 1 1 2 3 3 3 0 Septation ring formation regulator, EzrA YkyA PF10368.9 EMC88152.1 - 3.3 7.4 34.7 0.38 10.4 21.1 2.4 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein Spc7 PF08317.11 EMC88152.1 - 3.7 6.4 34.7 1.1 8.1 27.9 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein YabA PF06156.13 EMC88152.1 - 5.2 7.8 26.2 6.4 7.5 5.7 3.1 1 1 1 2 2 2 0 Initiation control protein YabA Fib_alpha PF08702.10 EMC88152.1 - 5.6 7.2 22.7 0.89 9.7 13.8 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DHR10 PF18595.1 EMC88152.1 - 6.5 6.8 37.4 1.8 8.7 20.7 3.0 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain PRKG1_interact PF15898.5 EMC88152.1 - 6.5 7.7 32.2 67 4.5 21.1 3.2 1 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain TMEM192 PF14802.6 EMC88152.1 - 6.7 5.7 8.8 44 3.1 8.8 2.0 1 1 0 1 1 1 0 TMEM192 family V_ATPase_I PF01496.19 EMC88152.1 - 7.4 4.4 19.6 0.8 7.6 14.8 1.6 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family GIT_CC PF16559.5 EMC88152.1 - 7.4 6.5 17.9 9.7 6.1 7.2 3.4 1 1 2 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor PhoU PF01895.19 EMC88152.1 - 7.6 7.1 8.2 2.5 8.6 2.3 2.7 3 0 0 3 3 3 0 PhoU domain GAS2 PF02187.17 EMC88153.1 - 1.1e-27 96.0 0.1 1.8e-27 95.2 0.1 1.4 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain CH PF00307.31 EMC88153.1 - 3.4e-14 52.9 0.0 5e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain MFS_1 PF07690.16 EMC88154.1 - 4.9e-50 170.4 24.8 1.3e-48 165.7 22.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily BT1 PF03092.16 EMC88154.1 - 0.16 10.2 5.5 0.42 8.8 0.0 2.9 3 0 0 3 3 3 0 BT1 family CybS PF05328.12 EMC88155.1 - 4.8 6.9 8.5 1.2e+02 2.3 0.0 4.4 2 1 3 5 5 5 0 CybS, succinate dehydrogenase cytochrome B small subunit Ras PF00071.22 EMC88156.1 - 8e-41 139.3 0.1 2.7e-40 137.6 0.1 1.7 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EMC88156.1 - 4.8e-32 110.7 0.0 6.4e-32 110.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC88156.1 - 1.4e-14 54.0 0.1 1.7e-14 53.6 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family TniB PF05621.11 EMC88156.1 - 6.4e-05 22.4 0.0 0.00013 21.4 0.0 1.6 1 0 0 1 1 1 1 Bacterial TniB protein Gtr1_RagA PF04670.12 EMC88156.1 - 0.00012 21.5 0.0 0.00014 21.3 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMC88156.1 - 0.00014 21.9 0.0 0.00019 21.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EMC88156.1 - 0.00027 20.4 0.0 0.00039 19.9 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EMC88156.1 - 0.0018 18.0 0.0 0.0041 16.9 0.0 1.5 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation DLIC PF05783.11 EMC88156.1 - 0.019 13.9 0.1 0.49 9.2 0.1 2.0 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) AAA_16 PF13191.6 EMC88156.1 - 0.025 15.0 0.0 0.041 14.3 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 EMC88156.1 - 0.05 13.1 0.1 0.099 12.2 0.0 1.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA PF00004.29 EMC88156.1 - 0.13 12.7 0.0 0.18 12.2 0.0 1.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Peptidase_M20 PF01546.28 EMC88157.1 - 6.7e-33 114.1 0.0 1e-32 113.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EMC88157.1 - 4.4e-17 62.0 0.0 7.5e-17 61.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Ntox3 PF15536.6 EMC88157.1 - 0.1 12.6 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial toxin 3 Sulfate_transp PF00916.20 EMC88158.1 - 1.4e-92 310.4 21.1 2.1e-92 309.8 21.1 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EMC88158.1 - 1.3e-25 89.3 0.0 2.1e-25 88.6 0.0 1.3 1 0 0 1 1 1 1 STAS domain DUF872 PF05915.12 EMC88158.1 - 0.69 10.1 5.1 3.4 7.9 0.1 3.1 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) Ras PF00071.22 EMC88159.1 - 1.9e-32 112.1 0.0 2.1e-32 112.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC88159.1 - 1.1e-12 48.2 0.0 1.6e-12 47.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC88159.1 - 9e-09 35.0 0.0 9.1e-09 35.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC88159.1 - 0.0037 16.8 0.0 0.015 14.9 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 EMC88159.1 - 0.036 14.1 0.0 0.041 13.9 0.0 1.2 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Asp PF00026.23 EMC88160.1 - 2.9e-120 401.4 0.1 3.4e-120 401.2 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EMC88160.1 - 4.7e-15 56.3 2.0 2.3e-11 44.3 0.2 2.5 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal A1_Propeptide PF07966.12 EMC88160.1 - 2.6e-08 33.6 0.9 3.9e-08 33.0 0.9 1.3 1 0 0 1 1 1 1 A1 Propeptide Asp_protease_2 PF13650.6 EMC88160.1 - 0.0051 17.4 0.3 1.5 9.6 0.0 2.9 2 2 0 2 2 2 2 Aspartyl protease DUF4692 PF15763.5 EMC88161.1 - 5.2e-23 82.3 0.3 6.3e-23 82.1 0.3 1.1 1 0 0 1 1 1 1 Regulator of human erythroid cell expansion (RHEX) 7tm_1 PF00001.21 EMC88162.1 - 1.9e-51 174.9 8.1 2.3e-51 174.7 8.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC88162.1 - 3.6e-09 36.4 4.4 5.5e-09 35.8 4.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 EMC88162.1 - 5.7e-06 25.9 0.0 1.3e-05 24.7 0.0 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 EMC88162.1 - 1.3e-05 25.1 1.7 2.3e-05 24.3 1.7 1.3 1 0 0 1 1 1 1 Olfactory receptor Srg PF02118.21 EMC88162.1 - 0.0061 16.3 4.3 0.0061 16.3 4.3 2.0 2 1 0 2 2 2 1 Srg family chemoreceptor zf-LITAF-like PF10601.9 EMC88162.1 - 5.2 7.4 16.1 5.3 7.4 0.1 4.2 4 0 0 4 4 4 0 LITAF-like zinc ribbon domain RhoGAP PF00620.27 EMC88163.1 - 8.8e-48 162.0 0.8 6.5e-47 159.2 0.0 2.8 2 1 1 3 3 3 1 RhoGAP domain FCH PF00611.23 EMC88163.1 - 2.8e-18 65.9 2.7 1.3e-17 63.8 2.7 2.2 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 EMC88163.1 - 2.9e-09 36.4 0.0 5.2e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC88163.1 - 2.3e-08 33.7 0.0 4.2e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC88163.1 - 3.1e-08 33.2 0.0 6.8e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Rnf-Nqr PF02508.14 EMC88163.1 - 0.19 11.7 0.3 0.33 10.9 0.3 1.2 1 0 0 1 1 1 0 Rnf-Nqr subunit, membrane protein FlaC_arch PF05377.11 EMC88163.1 - 0.44 11.0 12.1 0.15 12.5 2.3 3.8 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) KIP1 PF07765.12 EMC88163.1 - 1.9 8.7 5.5 16 5.7 1.3 3.3 2 0 0 2 2 2 0 KIP1-like protein Adhesin_P1_N PF18652.1 EMC88163.1 - 3.7 7.6 12.9 0.44 10.6 0.8 3.1 3 0 0 3 3 3 0 Adhesin P1 N-terminal domain Pkinase PF00069.25 EMC88164.1 - 1e-39 136.5 0.0 1.3e-39 136.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain TBK1_ULD PF18396.1 EMC88164.1 - 3.4e-32 110.2 1.4 5.8e-32 109.5 1.4 1.4 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Pkinase_Tyr PF07714.17 EMC88164.1 - 1.6e-24 86.6 0.0 2.2e-24 86.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC88164.1 - 0.00022 20.1 0.0 0.00082 18.3 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EMC88164.1 - 0.00065 19.1 0.0 0.0012 18.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EMC88164.1 - 0.12 12.2 0.0 1.2 9.0 0.0 2.0 1 1 0 2 2 2 0 Phosphotransferase enzyme family CortBP2 PF09727.9 EMC88165.1 - 2.2e-68 229.9 19.8 2.2e-68 229.9 19.8 2.4 2 0 0 2 2 2 1 Cortactin-binding protein-2 DUF3037 PF11236.8 EMC88165.1 - 2 8.9 14.1 0.56 10.6 0.6 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF3037) hDGE_amylase PF14701.6 EMC88165.1 - 2.2 7.3 12.5 3.9 6.5 12.5 1.3 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Rootletin PF15035.6 EMC88165.1 - 7.6 6.5 38.3 6.7 6.7 15.0 2.6 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF3399 PF11879.8 EMC88166.1 - 1.3e-44 150.8 7.2 1.3e-44 150.8 7.2 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF3399) Ion_trans PF00520.31 EMC88166.1 - 4.2e-43 147.4 14.4 6.4e-43 146.8 14.4 1.3 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 EMC88166.1 - 4.1e-29 100.8 0.1 1.2e-28 99.3 0.1 1.8 1 0 0 1 1 1 1 BTB/POZ domain Shal-type PF11601.8 EMC88166.1 - 1.8e-14 53.0 12.0 3.4e-14 52.1 12.0 1.5 1 0 0 1 1 1 1 Shal-type voltage-gated potassium channels, N-terminal Ion_trans_2 PF07885.16 EMC88166.1 - 3.9e-13 49.2 5.8 3.9e-13 49.2 5.8 2.5 2 0 0 2 2 2 1 Ion channel BTB_3 PF16017.5 EMC88166.1 - 1.8e-05 24.8 0.0 0.00014 21.9 0.0 2.4 2 0 0 2 2 2 1 BTB/POZ domain PKD_channel PF08016.12 EMC88166.1 - 0.0037 16.0 9.8 0.0062 15.3 9.8 1.4 1 1 0 1 1 1 1 Polycystin cation channel DUF702 PF05142.12 EMC88166.1 - 1.5 9.3 5.9 0.16 12.4 0.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF702) DEAD PF00270.29 EMC88167.1 - 7.6e-30 104.0 0.0 1.5e-29 103.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC88167.1 - 3.9e-25 88.4 0.0 3e-24 85.5 0.0 2.4 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC88167.1 - 5.1e-05 23.3 0.6 0.00011 22.3 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EMC88167.1 - 0.016 15.6 0.0 0.032 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EMC88167.1 - 0.045 14.0 0.2 0.33 11.2 0.2 2.4 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EMC88167.1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain CMS1 PF14617.6 EMC88167.1 - 0.23 10.8 0.0 0.23 10.8 0.0 2.0 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit FAM212 PF15342.6 EMC88168.1 - 1.3e-28 98.6 0.5 2.9e-28 97.4 0.5 1.7 1 0 0 1 1 1 1 FAM212 family Ras PF00071.22 EMC88169.1 - 3.5e-34 117.7 0.1 4e-34 117.5 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC88169.1 - 5.5e-11 42.7 0.0 1.1e-10 41.7 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EMC88169.1 - 2e-05 24.2 0.1 3.2e-05 23.5 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 EMC88169.1 - 4.9e-05 22.8 0.0 6e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1_Xtn PF16897.5 EMC88169.1 - 0.0028 17.6 0.1 0.0041 17.1 0.1 1.3 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain 7tm_2 PF00002.24 EMC88170.1 - 7e-70 235.1 19.8 9.9e-70 234.6 19.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 EMC88170.1 - 3.2e-18 65.8 8.2 6.2e-18 64.8 8.2 1.5 1 0 0 1 1 1 1 Hormone receptor domain DUF4034 PF13226.6 EMC88170.1 - 0.12 11.7 0.4 0.2 11.0 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4034) TssO PF17561.2 EMC88170.1 - 0.66 10.1 2.7 10 6.2 0.2 3.3 3 0 0 3 3 3 0 Type VI secretion system, TssO UPF0560 PF10577.9 EMC88171.1 - 6.9e-146 488.0 12.5 1.5e-99 334.6 2.4 2.1 1 1 1 2 2 2 2 Uncharacterised protein family UPF0560 Prominin PF05478.11 EMC88171.1 - 0.00054 18.1 0.1 0.0009 17.3 0.1 1.2 1 0 0 1 1 1 1 Prominin FAM163 PF15069.6 EMC88171.1 - 0.13 12.7 0.7 0.26 11.7 0.4 1.7 1 1 0 1 1 1 0 FAM163 family Integrin_alpha2 PF08441.12 EMC88172.1 - 2.6e-121 405.7 0.0 3.2e-121 405.5 0.0 1.1 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 EMC88172.1 - 5.1e-30 103.2 18.8 1.6e-09 37.7 0.2 4.7 4 0 0 4 4 4 4 FG-GAP repeat VCBS PF13517.6 EMC88172.1 - 1.6e-14 54.3 9.7 2.4e-05 24.8 0.4 4.3 3 1 0 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.20 EMC88172.1 - 8e-05 22.3 0.7 0.00017 21.3 0.7 1.6 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region LYRIC PF15686.5 EMC88172.1 - 0.00017 21.3 0.0 0.00025 20.7 0.0 1.1 1 0 0 1 1 1 1 Lysine-rich CEACAM1 co-isolated protein family DFRP_C PF16543.5 EMC88173.1 - 9.1e-23 80.6 1.5 9.1e-23 80.6 1.5 3.9 4 0 0 4 4 4 1 DRG Family Regulatory Proteins, Tma46 zf-CCCH_4 PF18044.1 EMC88173.1 - 7.5e-09 35.2 6.1 9.7e-07 28.5 1.2 3.3 3 0 0 3 3 3 2 CCCH-type zinc finger Torus PF16131.5 EMC88173.1 - 4.6e-07 30.5 11.8 2e-05 25.3 3.6 3.2 1 1 1 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 EMC88173.1 - 1.2e-06 28.4 6.1 1.2e-06 28.4 6.1 3.1 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH PF00642.24 EMC88173.1 - 2.6e-06 27.2 2.6 2.7e-06 27.1 0.9 2.0 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 EMC88173.1 - 0.0086 16.5 12.4 0.056 13.9 3.9 3.0 2 1 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 EMC88173.1 - 0.031 14.5 8.9 0.26 11.5 3.8 3.1 1 1 1 2 2 2 0 Zinc-finger containing family Keratin PF02422.16 EMC88181.1 - 6.3e-40 134.8 18.1 7.8e-40 134.5 18.1 1.1 1 0 0 1 1 1 1 Keratin Cadherin PF00028.17 EMC88182.1 - 1.7e-59 198.2 0.4 2.3e-16 60.0 0.0 5.3 5 0 0 5 5 5 4 Cadherin domain Cadherin_C PF01049.17 EMC88182.1 - 1.6e-06 28.5 0.0 3.7e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_2 PF08266.12 EMC88182.1 - 7.7e-06 25.7 0.0 0.79 9.6 0.0 3.4 3 0 0 3 3 3 3 Cadherin-like RET_CLD1 PF17756.1 EMC88182.1 - 0.00024 21.4 0.0 0.045 14.0 0.0 3.4 2 1 2 4 4 4 1 RET Cadherin like domain 1 Transthyretin PF00576.21 EMC88183.1 - 9.2e-21 74.6 0.1 1.2e-20 74.3 0.1 1.1 1 0 0 1 1 1 1 HIUase/Transthyretin family Lipase_C PF18067.1 EMC88183.1 - 0.013 16.1 0.0 0.018 15.6 0.0 1.3 1 0 0 1 1 1 0 Lipase C-terminal domain MSP1a PF11670.8 EMC88183.1 - 0.076 12.3 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) Transthyretin PF00576.21 EMC88184.1 - 1.3e-22 80.5 0.0 1.7e-22 80.2 0.0 1.1 1 0 0 1 1 1 1 HIUase/Transthyretin family TTR-52 PF01060.23 EMC88184.1 - 0.018 15.7 0.0 0.027 15.2 0.0 1.2 1 0 0 1 1 1 0 Transthyretin-like family Glyco_transf_7N PF13733.6 EMC88185.1 - 5.3e-55 184.7 0.0 8.4e-55 184.1 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.14 EMC88185.1 - 6.6e-28 96.2 0.7 1.2e-27 95.4 0.7 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase 7tm_1 PF00001.21 EMC88186.1 - 1.8e-34 119.2 16.2 2.1e-34 119.1 16.2 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC88186.1 - 0.0021 17.5 13.2 0.0027 17.1 13.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TAS2R PF05296.13 EMC88186.1 - 0.0037 16.4 9.4 0.022 13.9 0.2 2.0 2 0 0 2 2 2 2 Taste receptor protein (TAS2R) 7tm_4 PF13853.6 EMC88186.1 - 0.3 10.8 12.2 5.3 6.7 12.2 2.4 1 1 0 1 1 1 0 Olfactory receptor zf_C2HC_14 PF18574.1 EMC88188.1 - 2.4e-16 59.2 7.7 7.4e-16 57.6 7.7 1.9 1 0 0 1 1 1 1 C2HC Zing finger domain zf-Di19 PF05605.12 EMC88188.1 - 5.4e-15 55.4 2.3 5.4e-15 55.4 2.3 3.8 2 1 1 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding zf-C3HC4_2 PF13923.6 EMC88188.1 - 9.7e-14 50.9 10.1 9.7e-14 50.9 10.1 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC88188.1 - 3.4e-09 36.4 10.1 3.4e-09 36.4 10.1 4.0 3 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC88188.1 - 1.1e-08 34.9 6.2 1.1e-08 34.9 6.2 3.8 3 1 0 3 3 3 1 RING-type zinc-finger zf-RING_2 PF13639.6 EMC88188.1 - 2.6e-08 34.1 10.1 2.6e-08 34.1 10.1 4.0 4 1 2 6 6 5 1 Ring finger domain zf-C3HC4_3 PF13920.6 EMC88188.1 - 4.9e-07 29.5 6.8 4.9e-07 29.5 6.8 4.1 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC88188.1 - 8.7e-06 25.6 10.6 8.7e-06 25.6 10.6 4.1 4 1 1 5 5 5 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EMC88188.1 - 8.8e-06 25.8 9.1 8.8e-06 25.8 9.1 4.0 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 EMC88188.1 - 2.5e-05 24.0 6.5 2.5e-05 24.0 6.5 2.7 3 0 0 3 3 3 1 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 EMC88188.1 - 2.7e-05 23.9 3.6 2.7e-05 23.9 3.6 4.8 4 1 1 5 5 5 2 Prokaryotic RING finger family 4 zf-MIZ PF02891.20 EMC88188.1 - 0.00015 21.4 16.2 0.0039 16.9 7.2 3.6 3 0 0 3 3 3 2 MIZ/SP-RING zinc finger zf-RING_4 PF14570.6 EMC88188.1 - 0.00095 18.9 2.8 0.00095 18.9 2.8 4.3 5 0 0 5 5 5 1 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 EMC88188.1 - 0.0012 18.7 10.0 0.0045 16.8 5.5 2.7 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 EMC88188.1 - 0.0013 19.0 7.4 0.0013 19.0 7.4 3.7 4 0 0 4 4 4 1 RING-H2 zinc finger domain zf-RING_10 PF16685.5 EMC88188.1 - 0.0057 16.8 5.8 0.0057 16.8 5.8 3.2 3 1 0 3 3 3 1 zinc RING finger of MSL2 U-box PF04564.15 EMC88188.1 - 0.0098 16.0 0.0 0.027 14.6 0.0 1.8 1 0 0 1 1 1 1 U-box domain GAGA PF09237.11 EMC88188.1 - 1 9.2 18.0 0.11 12.3 1.4 4.4 3 1 1 4 4 4 0 GAGA factor Zn-C2H2_12 PF18112.1 EMC88188.1 - 2.1 8.9 19.3 0.49 10.9 0.3 4.7 4 0 0 4 4 4 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_4 PF13894.6 EMC88188.1 - 2.6 9.1 36.4 0.17 12.8 1.9 6.2 6 0 0 6 6 6 0 C2H2-type zinc finger zf-WRNIP1_ubi PF18279.1 EMC88188.1 - 3.4 8.5 12.9 10 7.0 0.2 4.7 4 0 0 4 4 4 0 Werner helicase-interacting protein 1 ubiquitin-binding domain Astacin PF01400.24 EMC88189.1 - 6.3e-71 237.9 0.1 1.1e-70 237.2 0.1 1.4 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) MAM PF00629.23 EMC88189.1 - 1.3e-40 139.0 0.2 3e-39 134.5 0.1 2.5 3 0 0 3 3 3 1 MAM domain, meprin/A5/mu EGF PF00008.27 EMC88189.1 - 0.00021 21.5 2.5 0.00061 20.0 2.5 1.8 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 EMC88189.1 - 0.024 15.3 2.2 0.1 13.3 2.2 2.2 1 0 0 1 1 1 0 Human growth factor-like EGF DAG1 PF05454.11 EMC88189.1 - 0.029 13.7 0.1 0.042 13.2 0.1 1.2 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) EGF_2 PF07974.13 EMC88189.1 - 2.5 8.5 5.5 8.8 6.8 5.5 2.0 1 0 0 1 1 1 0 EGF-like domain CABIT PF12736.7 EMC88190.1 - 1.3e-54 185.4 0.5 2.1e-54 184.8 0.5 1.2 1 0 0 1 1 1 1 Cell-cycle sustaining, positive selection, SAM_1 PF00536.30 EMC88190.1 - 0.0027 18.1 0.1 0.0049 17.3 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ras PF00071.22 EMC88191.1 - 2.4e-45 154.1 0.0 3.1e-45 153.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC88191.1 - 1e-20 74.1 0.0 1.6e-20 73.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC88191.1 - 7.8e-09 35.2 0.0 1.1e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC88191.1 - 0.00011 21.8 0.0 0.00019 21.0 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EMC88191.1 - 0.0037 16.6 0.0 0.0048 16.3 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region Sad1_UNC PF07738.13 EMC88193.1 - 1.7e-20 73.3 0.0 3.9e-20 72.2 0.0 1.5 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal TLV_coat PF00429.19 EMC88194.1 - 0.00012 21.0 1.6 0.00013 20.9 1.6 1.0 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) 7tm_4 PF13853.6 EMC88195.1 - 1.6e-43 149.4 14.3 2.1e-43 149.1 14.3 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC88195.1 - 8.2e-27 94.2 19.0 1.1e-26 93.7 19.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CholecysA-Rec_N PF09193.10 EMC88195.1 - 0.11 12.5 1.1 1.4 9.0 0.1 2.6 2 0 0 2 2 2 0 Cholecystokinin A receptor, N-terminal 7tm_4 PF13853.6 EMC88196.1 - 4.5e-50 171.0 11.3 5.6e-50 170.6 11.3 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC88196.1 - 2.2e-32 112.5 16.0 3.2e-32 111.9 16.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CholecysA-Rec_N PF09193.10 EMC88196.1 - 0.19 11.7 0.8 1.8 8.7 0.1 2.3 2 0 0 2 2 2 0 Cholecystokinin A receptor, N-terminal 7tm_4 PF13853.6 EMC88197.1 - 3.9e-51 174.4 18.5 4.3e-51 174.3 18.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC88197.1 - 5.2e-24 85.0 16.6 6.7e-24 84.6 16.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC88198.1 - 5.9e-48 164.0 15.1 6.8e-48 163.8 15.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC88198.1 - 3.5e-30 105.2 17.9 5.2e-30 104.7 17.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC88199.1 - 3.8e-20 72.8 5.7 1.3e-11 44.8 1.6 2.9 1 1 1 2 2 2 2 Olfactory receptor 7tm_1 PF00001.21 EMC88199.1 - 5e-14 52.3 10.7 9.9e-13 48.0 7.9 2.9 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) Dopey_N PF04118.14 EMC88200.1 - 0.0065 15.6 0.1 0.0065 15.6 0.1 1.1 1 0 0 1 1 1 1 Dopey, N-terminal DWNN PF08783.11 EMC88201.1 - 1.3e-13 51.0 0.0 1.9e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 DWNN domain PUFD PF16553.5 EMC88202.1 - 4.7e-51 171.7 0.2 1e-50 170.6 0.2 1.6 1 0 0 1 1 1 1 BCORL-PCGF1-binding domain Ank_2 PF12796.7 EMC88202.1 - 9.4e-19 67.8 6.6 4.2e-11 43.3 0.5 2.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC88202.1 - 1.2e-12 48.0 4.7 7e-07 29.7 0.3 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC88202.1 - 1.1e-10 40.7 0.4 2.8e-05 24.1 0.3 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EMC88202.1 - 3.1e-08 33.7 1.0 8.1e-05 22.9 0.2 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EMC88202.1 - 1.9e-07 31.2 2.3 4.7e-05 23.6 0.2 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) DHHC PF01529.20 EMC88203.1 - 2.7e-37 127.8 12.5 2.7e-37 127.8 12.5 1.7 2 0 0 2 2 2 1 DHHC palmitoyltransferase Peptidase_M24 PF00557.24 EMC88204.1 - 1.5e-34 119.5 0.0 1.9e-34 119.2 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 EMC88204.1 - 7.1e-21 74.0 0.1 1.1e-20 73.5 0.1 1.3 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 EMC88205.1 - 0.0032 18.1 0.0 0.0041 17.8 0.0 1.2 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain OCRL_clath_bd PF16726.5 EMC88206.1 - 2.1e-33 114.6 0.4 4.9e-33 113.4 0.4 1.7 1 0 0 1 1 1 1 Inositol polyphosphate 5-phosphatase clathrin binding domain RhoGAP PF00620.27 EMC88206.1 - 2.4e-25 89.1 0.2 4.3e-25 88.3 0.2 1.4 1 0 0 1 1 1 1 RhoGAP domain Exo_endo_phos PF03372.23 EMC88206.1 - 6.7e-15 55.2 0.0 1.1e-14 54.5 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Minor_capsid_3 PF12691.7 EMC88206.1 - 0.023 15.0 1.3 0.81 10.1 0.1 3.0 4 0 0 4 4 4 0 Minor capsid protein from bacteriophage SNF2_N PF00176.23 EMC88207.1 - 1.2e-50 172.2 0.5 1.4e-48 165.4 0.1 2.4 2 1 1 3 3 3 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EMC88207.1 - 6.6e-21 74.7 0.1 2.7e-19 69.5 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC88207.1 - 1.3e-13 51.3 0.0 1.5e-12 47.8 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_34 PF13872.6 EMC88207.1 - 4.5e-05 22.5 0.0 7e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 HDA2-3 PF11496.8 EMC88207.1 - 0.0001 21.6 0.0 0.00018 20.8 0.0 1.3 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 EMC88207.1 - 0.00011 22.0 0.0 0.00038 20.3 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EMC88207.1 - 0.00016 21.4 0.1 0.00044 20.0 0.0 1.8 2 0 0 2 2 2 1 SWI2/SNF2 ATPase DEAD_2 PF06733.15 EMC88207.1 - 0.032 13.9 0.0 0.088 12.4 0.0 1.7 1 0 0 1 1 1 0 DEAD_2 Rotamase_3 PF13616.6 EMC88208.1 - 3.3e-20 72.8 0.1 1.9e-19 70.3 0.1 2.0 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 EMC88208.1 - 4.3e-16 59.7 0.0 7.4e-16 58.9 0.0 1.4 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 EMC88208.1 - 0.0033 18.2 0.0 0.0048 17.7 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain NHS PF15273.6 EMC88209.1 - 1.1e-28 100.8 34.0 6.2e-26 91.7 21.5 2.9 2 1 1 3 3 3 2 NHS-like Amidase PF01425.21 EMC88211.1 - 1.1e-84 285.0 0.0 2.2e-84 284.0 0.0 1.5 1 1 0 1 1 1 1 Amidase Crystall PF00030.19 EMC88214.1 - 0.041 14.1 0.1 0.063 13.5 0.1 1.3 1 0 0 1 1 1 0 Beta/Gamma crystallin TraC_F_IV PF11130.8 EMC88214.1 - 0.12 12.0 0.1 0.16 11.6 0.1 1.2 1 0 0 1 1 1 0 F pilus assembly Type-IV secretion system for plasmid transfer 7tm_1 PF00001.21 EMC88215.1 - 1.4e-35 123.0 23.0 1.7e-35 122.6 23.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2976 PF11190.8 EMC88215.1 - 0.05 13.4 3.7 0.043 13.6 1.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) 7tm_1 PF00001.21 EMC88216.1 - 3.2e-37 128.3 21.7 4.2e-37 127.9 21.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC88216.1 - 6e-06 26.1 21.3 6e-06 26.1 21.3 2.3 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Alg14 PF08660.11 EMC88216.1 - 0.012 15.6 0.8 0.024 14.6 0.5 1.6 1 1 0 1 1 1 0 Oligosaccharide biosynthesis protein Alg14 like DUF4519 PF15012.6 EMC88216.1 - 0.66 10.2 0.1 0.66 10.2 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4519) PRIMA1 PF16101.5 EMC88216.1 - 1.5 8.9 3.5 0.87 9.6 0.9 1.9 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Saf_2TM PF18303.1 EMC88216.1 - 1.5 8.4 6.7 0.45 10.1 0.6 2.4 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain 7tm_1 PF00001.21 EMC88217.1 - 1e-28 100.4 21.8 1.3e-28 100.1 21.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ni_hydr_CYTB PF01292.20 EMC88217.1 - 0.0027 17.3 2.3 0.0053 16.4 0.6 2.0 1 1 1 2 2 2 1 Prokaryotic cytochrome b561 YtpI PF14007.6 EMC88217.1 - 0.96 9.6 0.0 0.96 9.6 0.0 4.1 2 1 2 4 4 4 0 YtpI-like protein 7tm_1 PF00001.21 EMC88218.1 - 4.6e-29 101.6 12.8 5.8e-29 101.2 12.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Fumarate_red_D PF02313.17 EMC88218.1 - 1.1 9.3 6.4 0.54 10.4 3.4 2.0 2 0 0 2 2 2 0 Fumarate reductase subunit D Synaptobrevin PF00957.21 EMC88219.1 - 0.16 11.8 0.0 0.16 11.8 0.0 2.2 2 0 0 2 2 2 0 Synaptobrevin DUF4205 PF13898.6 EMC88220.1 - 1.1e-28 100.2 0.0 1.2e-28 100.1 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4205) FAM194 PF14977.6 EMC88221.1 - 6.9e-56 188.8 0.0 8.7e-56 188.4 0.0 1.1 1 0 0 1 1 1 1 FAM194 protein 7tm_1 PF00001.21 EMC88222.1 - 1.2e-38 132.9 2.4 1.5e-38 132.7 2.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC88222.1 - 3.2e-06 27.1 1.0 0.001 18.8 2.6 2.1 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC88222.1 - 4.6e-06 26.4 0.3 7.7e-06 25.7 0.3 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 EMC88222.1 - 0.00075 18.9 1.9 0.00099 18.6 1.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.9 EMC88222.1 - 0.0013 18.3 1.3 0.0019 17.8 1.3 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc Rdx PF10262.9 EMC88223.1 - 3.2e-11 43.2 0.0 3.9e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 Rdx family SH3_3 PF08239.11 EMC88224.1 - 0.095 13.0 0.4 12 6.2 0.0 2.6 2 1 0 2 2 2 0 Bacterial SH3 domain DUF3309 PF11752.8 EMC88224.1 - 6.7 6.8 13.4 3.5 7.7 2.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3309) CK1gamma_C PF12605.8 EMC88225.1 - 3.6e-31 108.3 4.4 5.7e-31 107.6 4.4 1.3 1 0 0 1 1 1 1 Casein kinase 1 gamma C terminal Pkinase PF00069.25 EMC88225.1 - 1e-20 74.2 0.0 1.4e-20 73.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC88225.1 - 4.2e-11 42.6 0.0 5.6e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC88225.1 - 1.3e-08 34.1 0.2 1.9e-08 33.5 0.2 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pro_isomerase PF00160.21 EMC88226.1 - 2e-42 145.2 0.6 2.2e-42 145.0 0.6 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PX PF00787.24 EMC88227.1 - 7.2e-14 51.7 0.2 8.6e-14 51.5 0.2 1.1 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 EMC88228.1 - 6.6e-82 274.6 20.7 6.6e-82 274.6 20.7 1.5 2 0 0 2 2 2 1 Vps5 C terminal like PX PF00787.24 EMC88228.1 - 9e-28 96.5 0.9 3.1e-27 94.8 0.1 2.1 2 0 0 2 2 2 1 PX domain Sorting_nexin PF03700.13 EMC88228.1 - 1.4e-15 58.0 4.8 1.4e-15 58.0 4.8 2.0 2 0 0 2 2 2 1 Sorting nexin, N-terminal domain BAR_3_WASP_bdg PF10456.9 EMC88228.1 - 0.00014 21.4 2.7 0.0084 15.6 1.9 2.4 1 1 0 1 1 1 1 WASP-binding domain of Sorting nexin protein FUSC PF04632.12 EMC88228.1 - 0.18 10.3 6.1 0.26 9.8 6.1 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Csm2_III-A PF03750.13 EMC88228.1 - 0.2 12.5 3.7 10 7.0 0.8 2.9 2 0 0 2 2 2 0 Csm2 Type III-A HR1 PF02185.16 EMC88228.1 - 0.68 10.1 6.9 1.7 8.8 0.9 3.1 2 0 0 2 2 2 0 Hr1 repeat DUF2043 PF09740.9 EMC88228.1 - 1.3 9.7 5.0 1.4 9.6 2.5 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2043) YgaB PF14182.6 EMC88228.1 - 2 8.9 10.5 0.092 13.1 2.2 3.0 3 0 0 3 3 3 0 YgaB-like protein Arfaptin PF06456.13 EMC88228.1 - 2.6 7.6 12.6 0.074 12.6 3.5 2.4 2 0 0 2 2 2 0 Arfaptin-like domain PAT1 PF09770.9 EMC88229.1 - 2.4e-15 56.0 0.0 1.5e-12 46.7 0.0 2.1 2 0 0 2 2 2 2 Topoisomerase II-associated protein PAT1 C1-set PF07654.15 EMC88230.1 - 8.3e-21 74.2 0.0 9.7e-21 74.0 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.6 EMC88230.1 - 9.6e-05 22.9 0.0 0.00012 22.6 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC88230.1 - 0.0011 19.1 0.0 0.0016 18.6 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 EMC88230.1 - 0.0026 17.8 0.0 0.0036 17.3 0.0 1.2 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 EMC88230.1 - 0.0065 16.8 0.0 0.0088 16.4 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC88230.1 - 0.04 14.0 0.0 0.051 13.6 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin I-set domain TERB2 PF15101.6 EMC88231.1 - 9.7e-78 260.9 0.0 1.2e-77 260.7 0.0 1.0 1 0 0 1 1 1 1 Telomere-associated protein TERB2 Ribosomal_S17e PF00833.18 EMC88232.1 - 2.1e-69 231.1 0.4 2.4e-69 230.9 0.4 1.0 1 0 0 1 1 1 1 Ribosomal S17 CEBP1_N PF16368.5 EMC88233.1 - 2.8e-156 519.7 17.9 3.5e-156 519.4 17.9 1.1 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein 1 N-terminus RRM_7 PF16367.5 EMC88233.1 - 1.9e-36 124.1 0.0 5.1e-36 122.7 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif CEBP_ZZ PF16366.5 EMC88233.1 - 9.3e-25 86.7 7.5 9.3e-25 86.7 7.5 1.7 2 0 0 2 2 2 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.22 EMC88233.1 - 6.7e-07 29.0 0.0 0.05 13.4 0.0 3.1 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-B_box PF00643.24 EMC88233.1 - 3.5 7.8 5.6 7.3 6.8 5.6 1.4 1 0 0 1 1 1 0 B-box zinc finger AF-4 PF05110.13 EMC88233.1 - 7.5 4.5 7.5 11 4.0 7.5 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Adaptin_N PF01602.20 EMC88235.1 - 1e-62 212.4 2.7 1.1e-62 212.3 2.7 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EMC88235.1 - 0.00073 19.6 1.5 0.0044 17.1 0.4 2.2 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EMC88235.1 - 0.0088 16.4 0.1 0.27 11.6 0.0 2.3 1 1 2 3 3 3 3 HEAT repeats HEAT PF02985.22 EMC88235.1 - 0.092 13.1 0.0 28 5.3 0.0 3.2 3 0 0 3 3 3 0 HEAT repeat 7tm_4 PF13853.6 EMC88236.1 - 3.6e-46 158.2 5.7 4.6e-46 157.8 5.7 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC88236.1 - 5.4e-25 88.2 8.7 8.3e-25 87.6 8.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC88236.1 - 0.0074 15.9 2.3 0.0074 15.9 2.3 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Keratin PF02422.16 EMC88237.1 - 5.4e-39 131.8 17.8 6.8e-39 131.5 17.8 1.1 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC88238.1 - 7.4e-38 128.2 17.2 8.9e-38 127.9 17.2 1.1 1 0 0 1 1 1 1 Keratin V-set PF07686.17 EMC88239.1 - 2.1e-06 27.8 0.1 2.3e-06 27.7 0.1 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.6 EMC88239.1 - 0.0016 18.8 0.1 0.0019 18.5 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC88239.1 - 0.0095 16.5 0.1 0.012 16.2 0.1 1.3 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC88239.1 - 0.01 15.9 0.0 0.012 15.7 0.0 1.3 1 1 0 1 1 1 0 Immunoglobulin I-set domain 7tm_4 PF13853.6 EMC88240.1 - 5.8e-50 170.6 17.7 6.6e-50 170.4 17.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC88240.1 - 1.9e-20 73.3 25.0 2.6e-20 72.8 25.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4389 PF14333.6 EMC88240.1 - 7.1 6.6 16.6 0.75 9.7 0.6 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4389) Keratin PF02422.16 EMC88241.1 - 2.2e-39 133.0 12.1 2.5e-39 132.9 12.1 1.0 1 0 0 1 1 1 1 Keratin V-set PF07686.17 EMC88242.1 - 0.0002 21.5 0.0 0.00022 21.3 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Keratin PF02422.16 EMC88243.1 - 5.6e-42 141.3 11.4 6.4e-42 141.2 11.4 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC88244.1 - 9e-42 140.7 12.7 1e-41 140.5 12.7 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC88245.1 - 9.1e-42 140.7 12.7 1e-41 140.5 12.7 1.0 1 0 0 1 1 1 1 Keratin DUF4211 PF13926.6 EMC88248.1 - 8e-34 116.8 0.6 8e-34 116.8 0.6 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4211) DUF4196 PF13846.6 EMC88248.1 - 3.7e-14 52.9 0.9 3.7e-14 52.9 0.9 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF4196) Myotub-related PF06602.14 EMC88251.1 - 1.5e-153 510.9 0.1 1.9e-153 510.6 0.1 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.20 EMC88251.1 - 1.1e-18 67.1 0.0 2.2e-18 66.2 0.0 1.5 1 0 0 1 1 1 1 GRAM domain Y_phosphatase PF00102.27 EMC88251.1 - 0.00023 20.8 0.0 0.00046 19.8 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase 3-PAP PF12578.8 EMC88251.1 - 0.00096 18.9 0.1 0.0022 17.7 0.1 1.6 1 0 0 1 1 1 1 Myotubularin-associated protein DSPc PF00782.20 EMC88251.1 - 0.0039 17.0 0.0 0.0082 16.0 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC88251.1 - 0.03 14.3 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family NYD-SP28_assoc PF14775.6 EMC88251.1 - 0.042 14.0 5.8 0.77 9.9 0.9 3.3 3 0 0 3 3 3 0 Sperm tail C-terminal domain Cep57_CLD PF14073.6 EMC88252.1 - 1.2e-67 227.3 39.5 1.2e-67 227.3 39.5 2.3 2 0 0 2 2 2 1 Centrosome localisation domain of Cep57 Cep57_MT_bd PF06657.13 EMC88252.1 - 2.8e-20 72.5 3.1 2.8e-20 72.5 3.1 4.3 3 1 1 4 4 4 1 Centrosome microtubule-binding domain of Cep57 TMF_TATA_bd PF12325.8 EMC88252.1 - 0.017 15.3 10.6 0.017 15.3 10.6 4.2 2 2 2 4 4 4 0 TATA element modulatory factor 1 TATA binding Tsi6 PF18660.1 EMC88252.1 - 1.1 9.3 6.4 0.27 11.3 0.5 3.1 3 1 0 3 3 3 0 Tsi6 FAM76 PF16046.5 EMC88253.1 - 7.3e-91 304.6 34.3 8.3e-91 304.4 34.3 1.0 1 0 0 1 1 1 1 FAM76 protein MAP70 PF07058.11 EMC88253.1 - 0.0072 15.1 18.1 0.021 13.6 12.1 2.0 1 1 1 2 2 2 2 Microtubule-associated protein 70 Kinesin_assoc PF16183.5 EMC88253.1 - 0.52 10.4 5.5 0.32 11.1 1.3 2.1 2 0 0 2 2 2 0 Kinesin-associated DUF3552 PF12072.8 EMC88253.1 - 1.5 8.2 21.3 0.02 14.3 13.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) MPS2 PF17060.5 EMC88253.1 - 1.5 8.0 13.0 1.9 7.7 10.7 2.0 1 1 1 2 2 2 0 Monopolar spindle protein 2 NicO PF03824.16 EMC88253.1 - 2 7.7 7.0 3.4 6.9 7.0 1.3 1 0 0 1 1 1 0 High-affinity nickel-transport protein DUF2614 PF11023.8 EMC88253.1 - 3.1 7.9 8.4 1.2 9.2 1.2 2.3 1 1 1 2 2 2 0 Zinc-ribbon containing domain bZIP_2 PF07716.15 EMC88253.1 - 5.1 7.2 10.1 2.8 8.1 4.2 2.6 2 0 0 2 2 2 0 Basic region leucine zipper OmpH PF03938.14 EMC88253.1 - 5.3 7.4 16.2 0.68 10.3 11.6 1.8 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Metal_resist PF13801.6 EMC88253.1 - 5.5 7.2 5.9 26 5.0 0.2 2.3 2 0 0 2 2 2 0 Heavy-metal resistance Jnk-SapK_ap_N PF09744.9 EMC88253.1 - 6 7.1 20.9 0.92 9.7 9.1 2.4 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 PA26 PF04636.13 EMC88254.1 - 7.2e-204 677.7 0.9 8.2e-204 677.5 0.9 1.0 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) CMD PF02627.20 EMC88254.1 - 0.002 18.2 0.0 0.0061 16.6 0.0 1.9 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family KIP1 PF07765.12 EMC88254.1 - 0.28 11.3 2.8 0.43 10.7 1.3 2.1 2 0 0 2 2 2 0 KIP1-like protein Angiomotin_C PF12240.8 EMC88258.1 - 6.3e-94 313.3 39.9 2.2e-93 311.5 17.5 3.4 2 1 1 3 3 3 2 Angiomotin C terminal NPV_P10 PF05531.12 EMC88258.1 - 0.95 10.0 3.9 1.1 9.7 1.3 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Lebercilin PF15619.6 EMC88258.1 - 1.9 8.1 44.0 0.076 12.7 25.3 3.6 1 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Ank_4 PF13637.6 EMC88260.1 - 9.1e-32 109.0 3.8 5.4e-15 55.6 0.1 4.0 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EMC88260.1 - 3.5e-25 87.3 2.3 3.4e-09 36.8 0.0 4.4 4 1 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.7 EMC88260.1 - 9.3e-25 87.0 2.7 4.5e-10 40.0 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC88260.1 - 5.1e-23 78.7 1.1 1e-06 28.6 0.0 4.6 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EMC88260.1 - 7.2e-21 74.0 5.0 1.1e-09 38.4 0.1 3.3 1 1 1 3 3 3 2 Ankyrin repeats (many copies) RPN2_C PF18004.1 EMC88260.1 - 0.019 14.9 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Sulfotransfer_4 PF17784.1 EMC88260.1 - 0.07 12.9 0.7 0.11 12.3 0.7 1.4 1 0 0 1 1 1 0 Sulfotransferase domain Mre11_DNA_bind PF04152.14 EMC88261.1 - 4.6e-48 163.7 0.7 4.6e-48 163.7 0.7 2.1 2 0 0 2 2 2 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 EMC88261.1 - 3.9e-16 60.2 0.8 7.1e-16 59.3 0.8 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EMC88261.1 - 5.3e-06 26.7 0.0 5.2e-05 23.5 0.0 2.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain 7tm_1 PF00001.21 EMC88262.1 - 4.4e-51 173.7 24.2 5.6e-51 173.4 24.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC88262.1 - 2.6e-17 63.1 23.4 3.4e-17 62.7 23.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC88262.1 - 1.1e-05 25.3 17.0 1.6e-05 24.8 17.0 1.2 1 0 0 1 1 1 1 Olfactory receptor DUF2116 PF09889.9 EMC88262.1 - 0.19 11.7 1.4 0.39 10.7 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Innexin PF00876.18 EMC88263.1 - 1.2e-16 61.0 4.2 1.2e-16 61.0 4.2 1.6 1 1 1 2 2 2 1 Innexin DUF2207 PF09972.9 EMC88263.1 - 2.2 6.9 7.7 3.5 6.3 3.2 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Cu-oxidase_3 PF07732.15 EMC88264.1 - 9.8e-30 103.0 0.2 2.4e-10 40.5 0.0 5.0 5 0 0 5 5 5 3 Multicopper oxidase Cu-oxidase_2 PF07731.14 EMC88264.1 - 1e-23 83.6 10.0 3.3e-12 46.3 3.8 6.0 5 1 0 5 5 5 3 Multicopper oxidase L6_membrane PF05805.12 EMC88265.1 - 3.5e-65 219.2 16.4 4.3e-65 218.9 16.4 1.1 1 0 0 1 1 1 1 L6 membrane protein V-set PF07686.17 EMC88266.1 - 3.3e-05 24.0 0.1 5.4e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Receptor_2B4 PF11465.8 EMC88266.1 - 0.00044 20.4 0.2 0.00069 19.8 0.2 1.3 1 0 0 1 1 1 1 Natural killer cell receptor 2B4 I-set PF07679.16 EMC88266.1 - 0.022 14.8 0.3 0.061 13.4 0.3 1.8 1 1 0 1 1 1 0 Immunoglobulin I-set domain DUF1907 PF08925.11 EMC88267.1 - 1.1e-122 408.9 0.0 1.2e-122 408.7 0.0 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1907) TAF1D PF15333.6 EMC88268.1 - 5.3e-57 193.1 11.3 3.9e-56 190.2 11.3 1.9 1 1 0 1 1 1 1 TATA box-binding protein-associated factor 1D ALMS_motif PF15309.6 EMC88269.1 - 2.2e-26 93.0 20.7 3.1e-26 92.5 20.7 1.2 1 0 0 1 1 1 1 ALMS motif Stimulus_sens_1 PF13756.6 EMC88269.1 - 0.95 10.1 3.9 22 5.7 0.1 2.2 2 0 0 2 2 2 0 Stimulus-sensing domain DUF45 PF01863.17 EMC88269.1 - 3.3 7.7 11.3 26 4.8 11.3 2.0 1 1 0 1 1 1 0 Protein of unknown function DUF45 FlxA PF14282.6 EMC88269.1 - 4.9 7.2 15.7 0.062 13.3 4.0 2.5 3 0 0 3 3 3 0 FlxA-like protein DUF4519 PF15012.6 EMC88271.1 - 1.2e-28 99.1 5.1 1.3e-28 98.9 5.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4519) DUF4448 PF14610.6 EMC88271.1 - 0.00022 21.1 0.1 0.00023 21.0 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Orf78 PF06024.12 EMC88271.1 - 0.00097 19.4 0.0 0.00099 19.4 0.0 1.0 1 0 0 1 1 1 1 Orf78 (ac78) DUF2232 PF09991.9 EMC88271.1 - 0.0017 17.6 0.0 0.0019 17.5 0.0 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2232) FTCD_C PF04961.12 EMC88271.1 - 0.0026 17.5 0.1 0.0028 17.5 0.1 1.0 1 0 0 1 1 1 1 Formiminotransferase-cyclodeaminase DUF2208 PF09973.9 EMC88271.1 - 0.01 15.5 0.0 0.01 15.5 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) Vma12 PF11712.8 EMC88271.1 - 0.015 15.4 0.1 0.015 15.3 0.1 1.0 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase CrgA PF06781.12 EMC88271.1 - 0.016 15.3 0.2 0.017 15.2 0.2 1.0 1 0 0 1 1 1 0 Cell division protein CrgA EMC3_TMCO1 PF01956.16 EMC88271.1 - 0.052 13.3 0.1 0.058 13.1 0.1 1.0 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DUF515 PF04415.12 EMC88271.1 - 0.056 11.8 0.3 0.056 11.8 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF515) DUF3899 PF13038.6 EMC88271.1 - 0.06 13.8 0.0 0.06 13.8 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3899) DotU PF09850.9 EMC88271.1 - 0.072 12.8 0.1 0.077 12.7 0.1 1.0 1 0 0 1 1 1 0 Type VI secretion system protein DotU DUF3169 PF11368.8 EMC88271.1 - 0.078 12.5 0.0 0.088 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) DUF3357 PF11837.8 EMC88271.1 - 0.12 12.9 0.1 0.12 12.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) DUF5113 PF17140.4 EMC88271.1 - 0.13 12.0 0.1 0.15 11.8 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF5113) DUF2116 PF09889.9 EMC88271.1 - 0.75 9.8 2.9 1.1 9.3 2.9 1.4 1 1 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Adeno_E3_15_3 PF03307.14 EMC88272.1 - 0.025 14.5 1.0 0.025 14.5 1.0 1.6 2 0 0 2 2 2 0 Adenovirus 15.3kD protein in E3 region Golgin_A5 PF09787.9 EMC88272.1 - 0.12 11.8 28.3 0.14 11.6 28.3 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 V_ATPase_I PF01496.19 EMC88272.1 - 0.79 7.6 15.0 0.94 7.3 15.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_11 PF13086.6 EMC88272.1 - 1.7 8.4 10.8 2.1 8.0 10.8 1.2 1 0 0 1 1 1 0 AAA domain ALMT PF11744.8 EMC88272.1 - 3.5 6.4 12.9 3.9 6.2 12.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4250 PF14056.6 EMC88272.1 - 7.4 6.6 7.7 3.3 7.7 0.2 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF4250) CEP63 PF17045.5 EMC88273.1 - 1.1e-49 169.8 44.3 8e-49 167.0 44.3 1.8 1 1 0 1 1 1 1 Centrosomal protein of 63 kDa Tup_N PF08581.10 EMC88273.1 - 0.0085 16.4 8.0 0.0085 16.4 8.0 5.2 2 1 2 4 4 4 1 Tup N-terminal Spectrin PF00435.21 EMC88273.1 - 1.9 9.0 27.3 17 6.0 12.9 3.4 1 1 1 2 2 2 0 Spectrin repeat Sh_2 PF17512.2 EMC88273.1 - 4.3 7.1 6.0 1 9.1 1.6 2.0 2 1 0 2 2 2 0 Metapneumovirus Small hydrophobic protein Lectin_N PF03954.14 EMC88273.1 - 8.3 6.2 17.6 3.4 7.4 5.5 3.0 1 1 2 3 3 3 0 Hepatic lectin, N-terminal domain H-kinase_dim PF02895.14 EMC88273.1 - 8.8 6.8 14.5 5 7.6 3.4 3.4 2 1 1 3 3 3 0 Signal transducing histidine kinase, homodimeric domain UPAR_LY6 PF00021.21 EMC88274.1 - 7.8e-11 42.5 12.1 1e-10 42.2 12.1 1.1 1 0 0 1 1 1 1 u-PAR/Ly-6 domain Toxin_TOLIP PF00087.21 EMC88274.1 - 2.4e-07 30.9 15.4 3.1e-07 30.6 14.8 1.4 1 1 0 1 1 1 1 Snake toxin and toxin-like protein DUF4462 PF14692.6 EMC88274.1 - 0.13 11.7 1.4 0.45 10.0 0.8 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4462) SP2 PF03014.14 EMC88274.1 - 0.17 10.3 0.3 0.21 10.0 0.3 1.1 1 0 0 1 1 1 0 Structural protein 2 Topoisom_I PF01028.20 EMC88275.1 - 2.7e-102 341.0 8.4 2.7e-102 341.0 8.4 1.9 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 EMC88275.1 - 3.7e-100 333.8 4.1 3.7e-100 333.8 4.1 2.7 4 0 0 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 EMC88275.1 - 8.4e-35 118.5 0.7 2.8e-34 116.9 0.4 2.1 2 0 0 2 2 2 1 C-terminal topoisomerase domain DUF641 PF04859.12 EMC88275.1 - 0.0026 18.1 3.2 0.0026 18.1 3.2 3.4 2 1 1 3 3 3 1 Plant protein of unknown function (DUF641) DUF4407 PF14362.6 EMC88275.1 - 0.0048 16.3 6.2 0.0048 16.3 6.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4407) DUF3584 PF12128.8 EMC88275.1 - 0.14 9.6 18.6 0.0038 14.8 12.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) DUF2564 PF10819.8 EMC88275.1 - 0.15 12.4 7.3 0.49 10.8 7.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2564) Apolipoprotein PF01442.18 EMC88275.1 - 0.47 10.3 14.1 0.36 10.7 5.8 3.1 3 0 0 3 3 3 0 Apolipoprotein A1/A4/E domain UPF0242 PF06785.11 EMC88275.1 - 2.5 8.2 18.8 1.1 9.3 10.5 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Hormone_1 PF00103.20 EMC88275.1 - 3.6 7.3 11.3 0.49 10.1 3.1 3.0 3 0 0 3 3 3 0 Somatotropin hormone family Allexi_40kDa PF05549.11 EMC88275.1 - 3.9 6.9 7.1 7.1 6.0 3.0 2.4 2 0 0 2 2 2 0 Allexivirus 40kDa protein ZapB PF06005.12 EMC88275.1 - 7.6 7.1 21.0 1.7 9.1 10.0 3.5 3 0 0 3 3 3 0 Cell division protein ZapB NuiA PF07924.11 EMC88275.1 - 8.6 6.8 8.0 0.79 10.1 2.5 2.1 2 0 0 2 2 2 0 Nuclease A inhibitor-like protein BRO1 PF03097.18 EMC88276.1 - 1.5e-95 320.3 0.3 2.1e-95 319.8 0.3 1.2 1 0 0 1 1 1 1 BRO1-like domain HR1 PF02185.16 EMC88276.1 - 2.4e-20 72.4 4.8 5.5e-20 71.3 4.8 1.7 1 0 0 1 1 1 1 Hr1 repeat PDZ PF00595.24 EMC88276.1 - 3.6e-13 49.7 0.0 6.6e-13 48.8 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC88276.1 - 1.8e-12 46.9 0.1 3.7e-12 45.9 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC88276.1 - 2.4e-05 24.6 0.0 7.1e-05 23.0 0.0 1.7 2 0 0 2 2 2 1 PDZ domain FAM83 PF07894.12 EMC88276.1 - 0.0014 18.3 1.3 0.0015 18.2 0.1 1.7 2 0 0 2 2 2 1 FAM83 A-H Uds1 PF15456.6 EMC88276.1 - 0.03 14.5 3.7 0.07 13.3 3.7 1.6 1 0 0 1 1 1 0 Up-regulated During Septation Tricorn_PDZ PF14685.6 EMC88276.1 - 0.091 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Tricorn protease PDZ domain bZIP_Maf PF03131.17 EMC88277.1 - 7.1e-34 116.2 12.8 1e-33 115.7 12.8 1.2 1 0 0 1 1 1 1 bZIP Maf transcription factor Maf_N PF08383.11 EMC88277.1 - 5e-21 74.2 2.0 1.1e-20 73.0 2.0 1.7 1 0 0 1 1 1 1 Maf N-terminal region DUF737 PF05300.11 EMC88277.1 - 0.0011 19.3 0.4 0.0017 18.7 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF737) HOOK PF05622.12 EMC88277.1 - 0.0012 17.2 6.4 0.0015 16.8 6.4 1.0 1 0 0 1 1 1 1 HOOK protein bZIP_1 PF00170.21 EMC88277.1 - 0.0017 18.4 14.2 0.0041 17.2 14.2 1.6 1 1 0 1 1 1 1 bZIP transcription factor DUF1192 PF06698.11 EMC88277.1 - 0.018 15.1 1.1 7.6 6.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) bZIP_2 PF07716.15 EMC88277.1 - 0.025 14.7 8.3 0.025 14.7 8.3 1.9 1 1 1 2 2 2 0 Basic region leucine zipper KASH_CCD PF14662.6 EMC88277.1 - 0.068 13.0 8.9 0.13 12.1 8.5 1.5 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH FapA PF03961.13 EMC88277.1 - 0.082 11.5 3.2 0.11 11.1 3.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Peptidase_S49 PF01343.18 EMC88277.1 - 0.093 12.7 0.3 0.14 12.1 0.3 1.2 1 0 0 1 1 1 0 Peptidase family S49 Spc24 PF08286.11 EMC88277.1 - 0.29 11.4 2.5 0.23 11.7 0.8 1.7 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 UPF0449 PF15136.6 EMC88277.1 - 0.79 10.2 4.1 1.7 9.1 4.1 1.7 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 DivIC PF04977.15 EMC88277.1 - 3.5 7.5 9.7 0.7 9.7 5.1 2.0 1 1 1 2 2 2 0 Septum formation initiator zf-CCCH PF00642.24 EMC88278.1 - 1.8e-23 81.9 36.0 3.4e-07 30.0 4.4 6.1 4 2 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EMC88278.1 - 5e-13 48.6 40.2 0.00039 20.4 4.6 7.0 6 1 0 6 6 6 5 Zinc finger domain Torus PF16131.5 EMC88278.1 - 4.3e-11 43.5 29.5 0.017 15.8 2.4 5.4 1 1 4 5 5 5 5 Torus domain zf-CCCH_4 PF18044.1 EMC88278.1 - 2.4e-05 24.0 38.6 0.0015 18.3 0.2 6.1 5 2 0 5 5 5 4 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EMC88278.1 - 0.0017 18.5 22.0 0.025 14.8 8.1 2.9 1 1 1 2 2 2 2 Zinc-finger containing family zf-C3H1 PF10650.9 EMC88278.1 - 0.022 14.5 0.1 0.022 14.5 0.1 4.8 5 0 0 5 5 5 0 Putative zinc-finger domain zf-CCCH_2 PF14608.6 EMC88278.1 - 2.1 9.0 41.5 0.54 10.8 3.9 6.0 5 1 0 5 5 5 0 RNA-binding, Nab2-type zinc finger CAP_GLY PF01302.25 EMC88279.1 - 1.1e-31 108.7 0.9 1.3e-14 53.9 0.3 2.4 2 0 0 2 2 2 2 CAP-Gly domain UCH PF00443.29 EMC88279.1 - 2.3e-08 33.8 0.0 1.4e-07 31.2 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase NOB1_Zn_bind PF08772.11 EMC88279.1 - 0.024 14.8 1.5 0.064 13.4 1.5 1.7 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like NAPRTase_C PF17956.1 EMC88280.1 - 1.9e-29 102.3 0.0 3.4e-29 101.5 0.0 1.4 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase C-terminal domain NAPRTase PF04095.16 EMC88280.1 - 0.0058 16.3 0.0 0.26 10.9 0.0 2.1 2 0 0 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) family EF1_GNE PF00736.19 EMC88282.1 - 2.2e-37 127.1 1.1 4.5e-37 126.1 1.1 1.6 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 EMC88282.1 - 1.1e-12 48.1 8.4 1.1e-12 48.1 8.4 2.2 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region JIP_LZII PF16471.5 EMC88282.1 - 0.0026 17.9 0.6 0.0081 16.3 0.6 1.8 1 0 0 1 1 1 1 JNK-interacting protein leucine zipper II Lzipper-MIP1 PF14389.6 EMC88282.1 - 0.0079 16.5 0.0 2.7 8.4 0.0 2.9 2 0 0 2 2 2 1 Leucine-zipper of ternary complex factor MIP1 TSC22 PF01166.18 EMC88282.1 - 0.04 14.2 0.2 0.13 12.6 0.2 1.9 1 1 0 1 1 1 0 TSC-22/dip/bun family CCD48 PF15799.5 EMC88282.1 - 0.13 10.6 2.6 0.076 11.3 0.2 1.7 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 48 PBP1_TM PF14812.6 EMC88282.1 - 2.1 8.7 5.5 1.2 9.5 1.7 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Striatin PF08232.12 EMC88282.1 - 9.4 6.8 11.9 0.14 12.8 1.4 2.5 2 1 0 2 2 2 0 Striatin family HTH_Tnp_Tc5 PF03221.16 EMC88283.1 - 4e-14 52.4 0.0 1.1e-13 50.9 0.0 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.19 EMC88283.1 - 8e-09 35.4 0.0 5.1e-08 32.8 0.0 2.1 1 1 0 1 1 1 1 DDE superfamily endonuclease P5CR_dimer PF14748.6 EMC88284.1 - 4.9e-14 52.4 0.5 7.3e-14 51.9 0.5 1.3 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation Keratin PF02422.16 EMC88286.1 - 3e-36 123.0 4.8 3.5e-36 122.8 4.8 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC88287.1 - 2.1e-38 129.9 7.0 2.3e-38 129.7 7.0 1.0 1 0 0 1 1 1 1 Keratin SNF2_N PF00176.23 EMC88288.1 - 4e-21 75.1 0.1 1.2e-20 73.6 0.1 1.8 1 0 0 1 1 1 1 SNF2 family N-terminal domain ADD_ATRX PF17981.1 EMC88288.1 - 1.7e-20 72.6 4.2 5.5e-20 71.0 4.2 2.0 1 1 0 1 1 1 1 Cysteine Rich ADD domain AKAP28 PF14469.6 EMC88289.1 - 1.5e-53 179.7 2.6 1.7e-53 179.5 2.6 1.0 1 0 0 1 1 1 1 28 kDa A-kinase anchor Nkap_C PF06047.11 EMC88290.1 - 4.9e-50 167.9 2.0 4.9e-50 167.9 2.0 2.9 2 1 1 3 3 3 1 NF-kappa-B-activating protein C-terminal domain NKAP PF15692.5 EMC88290.1 - 1.4e-10 41.7 19.5 1.4e-10 41.7 19.5 4.0 2 1 1 3 3 3 1 NF-kappa-B-activating protein SOBP PF15279.6 EMC88290.1 - 0.28 11.8 16.0 0.52 10.9 16.0 1.5 1 0 0 1 1 1 0 Sine oculis-binding protein Ndc1_Nup PF09531.10 EMC88290.1 - 0.63 8.7 11.4 0.7 8.5 11.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PAP2 PF01569.21 EMC88291.1 - 1.7e-28 99.1 0.9 1.7e-28 99.1 0.9 1.5 2 0 0 2 2 2 1 PAP2 superfamily Bax1-I PF01027.20 EMC88291.1 - 0.071 12.9 0.8 2.8 7.7 0.0 2.1 2 0 0 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 PAP2_3 PF14378.6 EMC88291.1 - 0.91 9.2 6.4 33 4.1 6.4 2.6 1 1 0 1 1 1 0 PAP2 superfamily BTB PF00651.31 EMC88292.1 - 3.2e-26 91.7 0.5 4.9e-26 91.1 0.5 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 EMC88292.1 - 8.4e-09 35.5 2.6 8.4e-09 35.5 2.6 3.1 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.26 EMC88292.1 - 2.9e-06 27.4 14.5 0.0011 19.3 0.8 3.0 3 0 0 3 3 2 2 Zinc finger, C2H2 type DUF3342 PF11822.8 EMC88292.1 - 1.2e-05 25.5 0.2 2.3e-05 24.5 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) zf-C2H2_4 PF13894.6 EMC88292.1 - 7.7e-05 23.2 11.9 0.0075 17.0 0.7 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_5 PF13909.6 EMC88292.1 - 0.00025 20.7 3.6 0.00068 19.3 3.6 1.8 1 0 0 1 1 1 1 C2H2-type zinc-finger domain zf-met PF12874.7 EMC88292.1 - 0.00084 19.6 2.2 0.049 14.0 0.1 3.6 3 0 0 3 3 3 1 Zinc-finger of C2H2 type BTB_2 PF02214.22 EMC88292.1 - 0.018 15.4 0.1 0.038 14.3 0.1 1.6 1 0 0 1 1 1 0 BTB/POZ domain DUF3212 PF11486.8 EMC88292.1 - 0.04 13.9 0.2 0.085 12.9 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3212) zf-Di19 PF05605.12 EMC88292.1 - 0.069 13.5 4.1 0.15 12.4 4.1 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 EMC88292.1 - 0.083 13.2 2.8 0.73 10.2 0.0 3.0 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 EMC88292.1 - 0.4 10.8 4.8 2 8.6 0.3 2.7 1 1 1 2 2 2 0 Zinc ribbon domain PBP1_TM PF14812.6 EMC88292.1 - 0.55 10.6 6.6 1.3 9.4 0.3 2.5 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Elf1 PF05129.13 EMC88292.1 - 1.3 9.1 5.0 0.31 11.1 0.3 2.3 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like Archease PF01951.16 EMC88293.1 - 1.7e-44 151.4 0.1 2.2e-44 151.1 0.1 1.1 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) CAF1C_H4-bd PF12265.8 EMC88294.1 - 2.1e-27 95.2 2.2 1.5e-26 92.4 0.6 2.9 3 0 0 3 3 3 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EMC88294.1 - 9.4e-27 92.7 14.7 3.3e-07 30.9 0.0 5.8 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC88294.1 - 6.6e-05 23.1 1.2 0.013 15.8 0.0 3.6 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC88294.1 - 0.00014 21.8 0.6 0.024 14.5 0.0 3.1 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Capsid_NCLDV PF04451.12 EMC88294.1 - 0.071 12.9 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Large eukaryotic DNA virus major capsid protein DUF4224 PF13986.6 EMC88295.1 - 0.14 12.1 0.3 2e+02 1.9 0.0 4.7 3 2 3 6 6 6 0 Domain of unknown function (DUF4224) tRNA-synt_1b PF00579.25 EMC88296.1 - 8.7e-76 255.0 0.0 1.1e-75 254.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA_bind PF01588.20 EMC88296.1 - 3.5e-32 110.4 0.0 8.3e-32 109.2 0.0 1.7 1 0 0 1 1 1 1 Putative tRNA binding domain fn3 PF00041.21 EMC88297.1 - 3.1e-11 43.4 0.1 6.4e-11 42.5 0.0 1.5 2 0 0 2 2 2 1 Fibronectin type III domain Interfer-bind PF09294.10 EMC88297.1 - 0.023 15.0 0.2 0.055 13.8 0.1 1.6 1 1 0 1 1 1 0 Interferon-alpha/beta receptor, fibronectin type III UPF0270 PF06794.12 EMC88297.1 - 0.06 13.4 0.2 19 5.4 0.1 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0270) DUF4808 PF16066.5 EMC88297.1 - 0.12 13.0 1.5 0.58 10.7 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4808) EF-hand_7 PF13499.6 EMC88298.1 - 4.9e-27 94.2 2.8 1.1e-17 64.2 0.1 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EMC88298.1 - 8.1e-27 90.8 5.8 3.1e-07 29.5 0.0 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EMC88298.1 - 1.5e-23 80.7 1.0 5.6e-07 29.0 0.1 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 EMC88298.1 - 2.5e-23 80.5 4.5 3.1e-07 29.6 0.1 4.3 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EMC88298.1 - 2.3e-19 69.0 4.1 6.1e-07 29.2 0.2 3.6 2 2 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EMC88298.1 - 2.2e-07 31.2 0.2 0.0037 17.6 0.1 3.2 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EMC88298.1 - 8.1e-07 28.9 0.7 0.29 11.1 0.0 3.4 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 EMC88298.1 - 0.00085 19.1 0.1 2.1 8.3 0.0 3.1 3 0 0 3 3 3 2 EF hand Dockerin_1 PF00404.18 EMC88298.1 - 0.0051 17.0 0.2 4.9 7.4 0.1 2.9 2 1 0 2 2 2 2 Dockerin type I domain DUF832 PF05734.11 EMC88298.1 - 0.089 12.3 0.3 2.4 7.6 0.3 2.0 1 1 0 1 1 1 0 Herpesvirus protein of unknown function (DUF832) BCLP PF12304.8 EMC88299.1 - 7.3e-62 208.2 8.7 8.2e-62 208.0 8.7 1.0 1 0 0 1 1 1 1 Beta-casein like protein IBR PF01485.21 EMC88300.1 - 1.2e-18 67.1 42.1 5.6e-12 45.7 17.0 3.2 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain MDM1 PF15501.6 EMC88300.1 - 2 7.5 10.2 2.8 7.0 10.2 1.1 1 0 0 1 1 1 0 Nuclear protein MDM1 ADK PF00406.22 EMC88301.1 - 3.2e-42 144.2 0.0 3.5e-42 144.1 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EMC88301.1 - 9.4e-16 58.5 0.0 1.1e-15 58.3 0.0 1.0 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 EMC88301.1 - 4.9e-09 36.0 0.0 1.1e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid Orn_Arg_deC_N PF02784.16 EMC88302.1 - 2.7e-67 226.7 0.0 3.3e-67 226.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EMC88302.1 - 4.1e-07 30.2 0.0 5.3e-07 29.8 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.24 EMC88302.1 - 1.8e-05 24.3 0.0 9.8e-05 21.9 0.0 2.0 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel Ndufs5 PF10200.9 EMC88303.1 - 1.5e-06 28.4 0.3 1.7e-06 28.2 0.3 1.1 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa DUF5642 PF18702.1 EMC88304.1 - 0.099 12.4 0.6 0.19 11.5 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5642) ANAPC4_WD40 PF12894.7 EMC88305.1 - 4.6e-09 36.5 0.7 0.45 10.9 0.0 6.0 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 EMC88305.1 - 0.00061 19.6 0.4 0.89 9.6 0.0 3.6 3 0 0 3 3 3 2 PQQ enzyme repeat WD40 PF00400.32 EMC88305.1 - 0.0021 18.8 6.4 6.9 7.7 0.3 5.9 5 0 0 5 5 5 1 WD domain, G-beta repeat RAB3GAP2_N PF14655.6 EMC88305.1 - 0.0063 15.8 0.0 0.049 12.9 0.0 2.2 2 0 0 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit N-terminus PQQ_2 PF13360.6 EMC88305.1 - 0.02 14.5 0.3 0.56 9.7 0.0 3.2 3 0 0 3 3 3 0 PQQ-like domain Ser_hydrolase PF06821.13 EMC88305.1 - 0.079 12.8 0.1 0.16 11.8 0.1 1.4 1 0 0 1 1 1 0 Serine hydrolase Pkinase_Tyr PF07714.17 EMC88306.1 - 3.5e-105 351.0 0.0 4.7e-105 350.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC88306.1 - 6.4e-45 153.6 0.0 1e-44 152.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.16 EMC88306.1 - 1.6e-37 127.4 0.0 1.1e-14 54.3 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC88306.1 - 1.2e-35 121.9 0.0 4.1e-12 46.5 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 EMC88306.1 - 5.4e-26 90.6 0.0 5.7e-08 32.8 0.0 4.5 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 EMC88306.1 - 9.5e-26 90.0 0.0 1.3e-10 41.5 0.1 3.7 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 EMC88306.1 - 9.3e-16 58.0 1.6 0.00029 21.0 0.0 5.5 4 2 0 4 4 4 3 Immunoglobulin V-set domain FGFR3_TM PF18123.1 EMC88306.1 - 7e-15 54.2 4.1 7e-15 54.2 4.1 1.9 2 0 0 2 2 2 1 Fibroblast growth factor receptor 3 transmembrane domain Ig_5 PF16681.5 EMC88306.1 - 1.6e-06 28.4 0.0 0.6 10.5 0.0 3.9 3 2 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 EMC88306.1 - 2.3e-05 23.9 0.0 1.8 8.2 0.0 3.6 3 0 0 3 3 3 2 Immunoglobulin domain Ig_4 PF16680.5 EMC88306.1 - 0.0013 19.0 0.0 0.33 11.2 0.0 3.5 3 1 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 EMC88306.1 - 0.013 15.5 0.0 8.6 6.5 0.0 3.4 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain C2-set_2 PF08205.12 EMC88306.1 - 0.016 15.3 0.1 1 9.4 0.1 3.6 3 1 1 4 4 4 0 CD80-like C2-set immunoglobulin domain Kinase-like PF14531.6 EMC88306.1 - 0.066 12.5 0.0 0.26 10.6 0.0 1.8 2 0 0 2 2 2 0 Kinase-like ATE_C PF04377.15 EMC88307.1 - 3.1e-51 173.5 0.5 1.4e-50 171.4 0.2 2.1 2 1 1 3 3 3 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 EMC88307.1 - 1.1e-27 96.2 2.0 2.9e-27 94.9 2.0 1.8 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus DUF956 PF06115.11 EMC88307.1 - 0.046 13.4 0.0 0.079 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF956) Nse4_C PF08743.10 EMC88308.1 - 3.5e-25 88.1 0.3 7.5e-25 87.0 0.0 1.7 2 0 0 2 2 2 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 EMC88308.1 - 2.6e-15 56.2 1.8 5.8e-15 55.1 1.8 1.6 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE Plant_tran PF04827.14 EMC88308.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Plant transposon protein Yae1_N PF09811.9 EMC88309.1 - 3.6e-08 33.0 40.9 1.8e+02 1.9 32.1 4.1 2 1 0 2 2 2 0 Essential protein Yae1, N terminal PH PF00169.29 EMC88310.1 - 1.8e-32 111.9 0.2 5.1e-19 68.7 0.1 2.2 2 0 0 2 2 2 2 PH domain PH_8 PF15409.6 EMC88310.1 - 2.4e-12 46.9 0.1 2e-05 24.8 0.0 2.9 2 1 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.6 EMC88310.1 - 1.2e-08 35.3 1.9 3.3e-05 24.2 0.6 3.7 2 2 0 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.6 EMC88310.1 - 1.5e-07 31.8 0.2 0.027 14.9 0.1 2.5 2 1 0 2 2 2 2 Pleckstrin homology domain Mcp5_PH PF12814.7 EMC88310.1 - 1.3e-06 28.5 0.0 0.0022 18.1 0.0 2.4 2 0 0 2 2 2 2 Meiotic cell cortex C-terminal pleckstrin homology PH_3 PF14593.6 EMC88310.1 - 3.6e-05 23.8 0.8 0.009 16.1 0.2 2.8 2 2 0 2 2 2 1 PH domain PH_13 PF16652.5 EMC88310.1 - 0.012 15.4 0.2 1.8 8.4 0.0 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain PH_6 PF15406.6 EMC88310.1 - 0.015 15.5 0.0 5 7.5 0.0 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain Trypsin_2 PF13365.6 EMC88311.1 - 4.5e-32 112.0 0.1 6.5e-32 111.5 0.1 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EMC88311.1 - 3.6e-16 59.6 0.0 5.3e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 Trypsin PDZ_6 PF17820.1 EMC88311.1 - 6e-13 48.4 0.2 8.6e-12 44.7 0.1 2.4 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 EMC88311.1 - 5.8e-10 39.3 0.3 2.1e-09 37.6 0.3 2.0 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 EMC88311.1 - 6e-10 39.3 0.6 1.7e-09 37.9 0.1 2.1 2 0 0 2 2 2 1 PDZ domain Peptidase_S46 PF10459.9 EMC88311.1 - 8.7e-07 28.0 0.2 0.025 13.2 0.0 2.1 2 0 0 2 2 2 2 Peptidase S46 Peptidase_S32 PF05579.13 EMC88311.1 - 1.7e-05 24.1 0.1 0.076 12.2 0.0 2.1 2 0 0 2 2 2 2 Equine arteritis virus serine endopeptidase S32 DUF150_C PF17384.2 EMC88311.1 - 0.0029 17.7 0.9 0.42 10.8 0.3 2.6 2 0 0 2 2 2 1 RimP C-terminal SH3 domain LSM PF01423.22 EMC88311.1 - 0.0057 16.3 0.5 0.015 15.0 0.1 1.8 2 0 0 2 2 2 1 LSM domain GRASP55_65 PF04495.14 EMC88311.1 - 0.019 15.3 0.0 0.048 14.0 0.0 1.6 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain CUB PF00431.20 EMC88312.1 - 1.4e-225 733.6 0.0 5.8e-27 94.2 0.0 8.1 8 0 0 8 8 8 8 CUB domain CUB_2 PF02408.20 EMC88312.1 - 8.6e-19 67.5 0.0 0.33 10.7 0.0 8.5 8 0 0 8 8 8 7 CUB-like domain RabGGT_insert PF07711.11 EMC88312.1 - 0.0068 16.9 0.0 39 4.8 0.0 5.0 6 0 0 6 6 6 1 Rab geranylgeranyl transferase alpha-subunit, insert domain CfAFP PF05264.11 EMC88312.1 - 0.054 13.5 1.4 49 3.9 0.0 4.9 5 0 0 5 5 5 0 Choristoneura fumiferana antifreeze protein (CfAFP) SRCR PF00530.18 EMC88313.1 - 6.6e-60 199.9 14.4 8.5e-33 112.8 5.7 2.0 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 EMC88313.1 - 5.7e-08 33.2 1.2 0.015 15.8 0.1 2.5 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 EMC88313.1 - 0.067 13.7 0.1 18 5.9 0.1 2.4 2 0 0 2 2 2 0 Hepsin, SRCR domain DUF3027 PF11228.8 EMC88313.1 - 0.12 12.3 4.9 5.1 7.1 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3027) Crust_neurohorm PF01147.17 EMC88313.1 - 0.22 11.4 1.2 23 4.9 0.1 2.5 2 0 0 2 2 2 0 Crustacean CHH/MIH/GIH neurohormone family CUB PF00431.20 EMC88314.1 - 5.3e-15 55.7 0.0 8.9e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 CUB domain Zona_pellucida PF00100.23 EMC88314.1 - 6.5e-14 52.3 0.6 6.5e-14 52.3 0.6 1.6 2 0 0 2 2 2 1 Zona pellucida-like domain SRCR PF00530.18 EMC88315.1 - 3.8e-65 216.7 20.4 6.8e-33 113.2 5.8 2.0 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 EMC88315.1 - 9.2e-08 32.5 2.2 0.011 16.2 0.1 2.6 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain DUF3027 PF11228.8 EMC88315.1 - 0.089 12.8 4.9 4.4 7.3 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3027) Crust_neurohorm PF01147.17 EMC88315.1 - 0.33 10.8 3.6 11 5.9 0.3 2.5 2 0 0 2 2 2 0 Crustacean CHH/MIH/GIH neurohormone family SRCR PF00530.18 EMC88316.1 - 9.8e-64 212.1 17.7 1.5e-32 112.1 3.6 2.0 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 EMC88316.1 - 2.5e-11 44.0 6.0 4e-05 24.1 0.7 2.4 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 EMC88316.1 - 0.0003 21.3 0.3 1 9.9 0.0 2.4 2 0 0 2 2 2 2 Hepsin, SRCR domain SRCR PF00530.18 EMC88317.1 - 1.3e-63 211.7 17.4 5.4e-32 110.3 5.1 2.0 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 EMC88317.1 - 2.6e-09 37.5 6.0 3e-05 24.5 1.0 2.5 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 EMC88317.1 - 0.014 15.9 0.3 0.42 11.1 0.0 2.3 2 0 0 2 2 2 0 Hepsin, SRCR domain TYW3 PF02676.14 EMC88317.1 - 0.27 10.6 0.7 22 4.3 0.0 2.3 2 1 0 2 2 2 0 Methyltransferase TYW3 DUF4506 PF14958.6 EMC88318.1 - 6.2e-37 126.2 0.1 1.1e-36 125.5 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4506) KTI12 PF08433.10 EMC88319.1 - 1.2e-13 51.1 2.5 1.7e-13 50.6 2.5 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 EMC88319.1 - 0.0045 17.2 0.0 0.014 15.5 0.0 1.9 2 1 0 2 2 2 1 AAA domain DUF4259 PF14078.6 EMC88319.1 - 0.028 15.2 1.8 0.045 14.5 1.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4259) Nefa_Nip30_N PF10187.9 EMC88319.1 - 0.15 12.4 3.0 0.37 11.2 3.0 1.7 1 1 0 1 1 1 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 zf-H2C2_2 PF13465.6 EMC88320.1 - 1.7e-12 47.2 45.2 3e-07 30.5 4.0 6.2 6 0 0 6 6 6 3 Zinc-finger double domain zf-H2C2_5 PF13909.6 EMC88320.1 - 2e-11 43.4 31.9 2.2e-05 24.1 0.1 4.6 4 0 0 4 4 4 3 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 EMC88320.1 - 8.3e-07 29.1 49.3 0.067 13.7 7.9 5.4 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC88320.1 - 0.0028 18.4 44.6 0.75 10.8 6.7 5.5 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EMC88320.1 - 2.5 8.5 0.0 2.5 8.5 0.0 4.9 2 2 3 5 5 5 0 C2H2 type zinc-finger (2 copies) Acyl-CoA_dh_1 PF00441.24 EMC88321.1 - 2e-50 170.9 0.5 5.3e-49 166.3 0.2 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EMC88321.1 - 9.2e-28 97.2 0.1 1.9e-27 96.2 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EMC88321.1 - 1.4e-26 92.5 0.0 2.7e-26 91.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EMC88321.1 - 6.5e-25 88.0 0.0 1.2e-24 87.1 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain WD40 PF00400.32 EMC88322.1 - 2.4e-22 78.8 3.6 2.1e-05 25.2 0.0 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC88322.1 - 7.7e-07 29.3 0.0 1.2 9.5 0.0 4.4 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMC88322.1 - 0.14 11.1 0.0 0.78 8.6 0.0 2.2 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein 7tm_1 PF00001.21 EMC88323.1 - 7.9e-37 127.0 15.9 1e-36 126.6 15.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC88323.1 - 1.2e-07 31.7 17.5 1.2e-07 31.7 17.5 2.0 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Git3 PF11710.8 EMC88323.1 - 1.3e-05 25.0 10.5 2.3e-05 24.3 10.3 1.5 1 1 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7TM_GPCR_Srbc PF10316.9 EMC88323.1 - 0.00068 19.2 7.6 0.00068 19.2 7.6 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc TssO PF17561.2 EMC88323.1 - 0.32 11.1 6.7 0.92 9.6 0.5 2.6 2 0 0 2 2 2 0 Type VI secretion system, TssO Peptidase_M14 PF00246.24 EMC88324.1 - 3.9e-73 246.8 0.2 6.5e-73 246.0 0.1 1.4 2 0 0 2 2 2 1 Zinc carboxypeptidase F5_F8_type_C PF00754.25 EMC88324.1 - 5.6e-28 97.6 0.1 2.2e-27 95.7 0.1 2.1 2 0 0 2 2 2 1 F5/8 type C domain CarboxypepD_reg PF13620.6 EMC88324.1 - 4.1e-13 49.4 0.1 9.2e-13 48.3 0.1 1.6 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 EMC88324.1 - 7.4e-06 25.9 0.1 1.5e-05 24.9 0.1 1.5 1 0 0 1 1 1 1 CarboxypepD_reg-like domain PEGA PF08308.11 EMC88324.1 - 0.0038 17.1 0.0 0.0087 15.9 0.0 1.6 1 0 0 1 1 1 1 PEGA domain Sulfotransfer_1 PF00685.27 EMC88325.1 - 1.5e-15 57.5 0.0 1.7e-12 47.4 0.1 2.3 2 0 0 2 2 2 2 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC88325.1 - 1.1e-12 48.8 0.1 4e-12 47.0 0.1 1.9 1 1 0 1 1 1 1 Sulfotransferase family PVL_ORF50 PF07768.11 EMC88325.1 - 0.031 14.6 0.1 0.068 13.5 0.1 1.5 1 0 0 1 1 1 0 PVL ORF-50-like family Aminotran_3 PF00202.21 EMC88326.1 - 1.2e-121 406.1 0.0 1.5e-121 405.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EMC88326.1 - 0.029 13.6 0.0 0.049 12.8 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Hydrolase_like PF13242.6 EMC88327.1 - 1.8e-17 63.1 0.0 4.4e-16 58.7 0.0 2.2 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 EMC88327.1 - 1.2e-08 35.0 0.0 2.5e-08 33.9 0.0 1.7 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EMC88327.1 - 0.0012 19.0 0.0 0.012 15.7 0.0 2.2 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Nif11 PF07862.11 EMC88327.1 - 0.18 12.1 0.0 0.32 11.3 0.0 1.4 1 0 0 1 1 1 0 Nif11 domain Methyltransf_31 PF13847.6 EMC88329.1 - 8.2e-21 74.4 0.0 1.1e-20 74.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC88329.1 - 2e-12 47.6 0.0 3.2e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC88329.1 - 7.3e-10 39.4 0.0 1.1e-09 38.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC88329.1 - 3.7e-09 37.2 0.0 5.3e-09 36.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC88329.1 - 7.7e-09 35.6 0.0 2.8e-08 33.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EMC88329.1 - 2e-06 27.4 0.0 2.3e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EMC88329.1 - 3.4e-06 26.7 0.0 6.1e-06 25.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain TPMT PF05724.11 EMC88329.1 - 0.00013 21.7 0.0 0.0002 21.1 0.0 1.2 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Ubie_methyltran PF01209.18 EMC88329.1 - 0.00023 20.6 0.0 0.0003 20.2 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_24 PF13578.6 EMC88329.1 - 0.00047 21.1 0.0 0.00064 20.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EMC88329.1 - 0.00067 19.0 0.0 0.00094 18.6 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 EMC88329.1 - 0.00079 18.9 0.0 0.0016 18.0 0.0 1.6 1 1 0 1 1 1 1 Putative methyltransferase TehB PF03848.14 EMC88329.1 - 0.0036 16.7 0.0 0.0058 16.1 0.0 1.4 1 1 0 1 1 1 1 Tellurite resistance protein TehB Pox_MCEL PF03291.16 EMC88329.1 - 0.0042 16.2 0.0 0.028 13.6 0.0 1.9 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_18 PF12847.7 EMC88329.1 - 0.014 15.3 0.0 0.023 14.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 EMC88329.1 - 0.023 14.5 0.0 0.028 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) NNMT_PNMT_TEMT PF01234.17 EMC88329.1 - 0.034 13.3 0.0 5.2 6.2 0.0 2.1 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family MetW PF07021.12 EMC88329.1 - 0.042 13.5 0.0 0.054 13.1 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW AdoMet_MTase PF07757.13 EMC88329.1 - 0.043 14.2 0.0 0.07 13.5 0.0 1.4 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Methyltransf_32 PF13679.6 EMC88329.1 - 0.045 13.7 0.0 0.056 13.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Cluap1 PF10234.9 EMC88330.1 - 0.0024 17.3 1.8 0.0035 16.8 1.8 1.2 1 0 0 1 1 1 1 Clusterin-associated protein-1 Pepdidase_M14_N PF18027.1 EMC88330.1 - 0.075 13.4 0.5 4.7 7.6 0.1 2.4 2 0 0 2 2 2 0 Cytosolic carboxypeptidase N-terminal domain Spore_II_R PF09551.10 EMC88330.1 - 0.25 11.8 2.3 0.28 11.6 0.8 1.8 2 0 0 2 2 2 0 Stage II sporulation protein R (spore_II_R) COG2 PF06148.11 EMC88330.1 - 0.47 10.6 3.7 0.86 9.7 3.7 1.4 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 AnkUBD PF18418.1 EMC88331.1 - 9.1e-52 173.2 0.1 1.9e-51 172.1 0.1 1.5 1 0 0 1 1 1 1 Ankyrin ubiquitin-binding domain OTU PF02338.19 EMC88331.1 - 1e-38 132.7 0.1 2.5e-38 131.4 0.0 1.7 2 0 0 2 2 2 1 OTU-like cysteine protease zf-RanBP PF00641.18 EMC88331.1 - 1.1e-07 31.0 40.1 1.5e-05 24.2 6.2 4.1 4 0 0 4 4 4 3 Zn-finger in Ran binding protein and others DZR PF12773.7 EMC88331.1 - 0.041 13.9 14.9 1.3 9.1 8.1 3.1 1 1 1 2 2 2 0 Double zinc ribbon Copper-fist PF00649.18 EMC88331.1 - 1.2 8.7 4.2 2.8 7.5 0.4 2.9 2 0 0 2 2 2 0 Copper fist DNA binding domain 2-Hacid_dh_C PF02826.19 EMC88332.1 - 2.6e-55 186.5 0.0 4.6e-55 185.7 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EMC88332.1 - 1.3e-29 102.5 0.1 1.7e-29 102.2 0.1 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EMC88332.1 - 0.045 13.9 0.0 0.099 12.8 0.0 1.6 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase HDNR PF15115.6 EMC88333.1 - 2.1e-15 57.4 0.2 2.4e-15 57.2 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function with conserved HDNR motif DUF2315 PF10231.9 EMC88334.1 - 0.26 11.4 3.4 1.1 9.4 1.8 2.5 2 0 0 2 2 2 0 Apoptogenic protein 1 TPR_2 PF07719.17 EMC88334.1 - 0.65 10.3 11.2 0.7 10.2 0.7 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EMC88334.1 - 1.2 9.5 6.2 17 6.0 1.3 3.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EMC88334.1 - 7 6.7 6.1 7.1 6.6 0.5 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat HEM4 PF02602.15 EMC88335.1 - 6.9e-49 166.3 0.0 7.8e-49 166.1 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD BCIP PF13862.6 EMC88336.1 - 1.2e-62 211.4 5.9 1.4e-62 211.1 5.9 1.0 1 0 0 1 1 1 1 p21-C-terminal region-binding protein Spt5_N PF11942.8 EMC88336.1 - 0.069 14.1 3.1 0.14 13.1 0.6 2.3 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Reprolysin PF01421.19 EMC88337.1 - 1.5e-73 247.0 0.0 1.5e-73 247.0 0.0 1.8 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 EMC88337.1 - 2.2e-33 115.1 4.3 2.2e-33 115.1 4.3 3.3 3 1 0 3 3 3 1 ADAM cysteine-rich Pep_M12B_propep PF01562.19 EMC88337.1 - 8.2e-30 103.9 0.1 1.6e-29 102.9 0.1 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.6 EMC88337.1 - 5.1e-21 75.7 0.0 1.1e-20 74.6 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Disintegrin PF00200.23 EMC88337.1 - 1.8e-19 70.3 28.2 1.8e-19 70.3 28.2 4.2 3 1 0 3 3 3 1 Disintegrin Reprolysin_3 PF13582.6 EMC88337.1 - 1.4e-14 54.7 0.0 2.6e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EMC88337.1 - 2.7e-14 53.3 0.0 4.3e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EMC88337.1 - 2.3e-13 50.5 0.0 4.1e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 EMC88337.1 - 0.067 12.1 0.2 0.11 11.5 0.2 1.2 1 0 0 1 1 1 0 Peptidase M66 Zincin_1 PF06262.11 EMC88337.1 - 0.11 12.7 0.1 0.21 11.7 0.1 1.4 1 0 0 1 1 1 0 Zincin-like metallopeptidase DOCK_N PF16172.5 EMC88338.1 - 2.6e-113 378.8 0.2 5.7e-113 377.6 0.2 1.6 1 0 0 1 1 1 1 DOCK N-terminus DHR-2 PF06920.13 EMC88338.1 - 2.3e-101 340.1 11.1 6.6e-101 338.5 11.1 1.8 1 1 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 EMC88338.1 - 7.5e-64 215.1 0.2 2.4e-63 213.5 0.2 2.0 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins SH3_9 PF14604.6 EMC88338.1 - 2e-10 40.3 0.0 4.2e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC88338.1 - 1.3e-09 37.5 0.0 2.7e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC88338.1 - 4.2e-06 26.3 0.0 9.8e-06 25.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SR-25 PF10500.9 EMC88338.1 - 0.11 12.1 9.7 0.32 10.6 9.7 1.7 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Neuropeptide_S PF14993.6 EMC88339.1 - 3.7e-21 74.7 3.9 1.1e-19 70.0 3.9 2.2 1 1 0 1 1 1 1 Neuropeptide S precursor protein Claudin_2 PF13903.6 EMC88340.1 - 0.00086 19.1 9.1 0.0015 18.3 9.1 1.4 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Mito_carr PF00153.27 EMC88340.1 - 0.023 14.6 0.2 0.054 13.4 0.2 1.7 1 0 0 1 1 1 0 Mitochondrial carrier protein CD34_antigen PF06365.12 EMC88340.1 - 0.04 13.5 0.3 0.3 10.6 0.0 2.0 2 0 0 2 2 2 0 CD34/Podocalyxin family TssO PF17561.2 EMC88340.1 - 0.089 12.9 0.0 0.089 12.9 0.0 2.1 3 0 0 3 3 3 0 Type VI secretion system, TssO Sid-5 PF17204.3 EMC88340.1 - 0.12 12.5 0.1 2.5 8.3 0.0 2.4 2 0 0 2 2 2 0 Sid-5 family RAMP4 PF06624.12 EMC88340.1 - 0.16 12.1 0.2 0.45 10.6 0.0 1.8 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 DUF4220 PF13968.6 EMC88340.1 - 0.31 10.4 9.1 0.095 12.1 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4220) Virul_fac_BrkB PF03631.15 EMC88340.1 - 7.2 6.1 16.0 1.7 8.2 0.8 2.8 2 1 0 2 2 2 0 Virulence factor BrkB zf-LITAF-like PF10601.9 EMC88340.1 - 7.4 6.9 12.8 11 6.4 0.0 3.7 4 0 0 4 4 4 0 LITAF-like zinc ribbon domain KRTAP PF11759.8 EMC88341.1 - 1.9 9.1 77.4 1.8e+04 -37.0 77.4 3.6 1 1 0 1 1 1 0 Keratin-associated matrix PsbL PF02419.17 EMC88342.1 - 2.1 8.4 7.3 3.6 7.6 7.3 1.3 1 0 0 1 1 1 0 PsbL protein LIM PF00412.22 EMC88343.1 - 1.6e-10 41.1 0.1 1.9e-10 40.8 0.1 1.1 1 0 0 1 1 1 1 LIM domain zf-HC5HC2H PF13771.6 EMC88344.1 - 8.5e-18 64.4 3.2 8.5e-18 64.4 3.2 3.5 3 2 0 3 3 3 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EMC88344.1 - 2.3e-10 40.6 4.3 2.3e-10 40.6 4.3 3.1 2 1 1 3 3 3 1 PHD-zinc-finger like domain zf-RING_2 PF13639.6 EMC88344.1 - 2e-06 28.0 9.0 2e-06 28.0 9.0 4.3 4 1 0 4 4 4 2 Ring finger domain zf-RING_11 PF17123.5 EMC88344.1 - 0.0021 17.7 3.3 0.0021 17.7 3.3 3.6 3 1 0 3 3 3 1 RING-like zinc finger PPTA PF01239.22 EMC88344.1 - 0.79 9.5 0.0 0.79 9.5 0.0 2.6 3 0 0 3 3 3 0 Protein prenyltransferase alpha subunit repeat CPSase_L_D2 PF02786.17 EMC88345.1 - 2.2e-86 288.7 0.0 3e-86 288.3 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 EMC88345.1 - 6.6e-37 125.9 0.0 1.2e-36 125.1 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain PCC_BT PF18140.1 EMC88345.1 - 3.1e-18 66.4 0.0 7.8e-18 65.0 0.0 1.6 1 0 0 1 1 1 1 Propionyl-coenzyme A carboxylase BT domain Dala_Dala_lig_C PF07478.13 EMC88345.1 - 8.1e-09 35.3 0.0 3.6e-08 33.2 0.0 1.9 1 1 1 2 2 2 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EMC88345.1 - 2.1e-07 30.7 0.0 3.5e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 EMC88345.1 - 0.00015 21.4 0.0 0.00028 20.5 0.0 1.4 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 EMC88345.1 - 0.0003 20.9 0.0 0.00052 20.1 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain SLT_beta PF02258.16 EMC88345.1 - 0.013 15.5 0.0 0.033 14.2 0.0 1.6 1 0 0 1 1 1 0 Shiga-like toxin beta subunit ATP-grasp_5 PF13549.6 EMC88345.1 - 0.016 14.6 0.0 0.043 13.3 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain ATPgrasp_ST PF14397.6 EMC88345.1 - 0.046 13.0 0.0 0.22 10.7 0.0 1.9 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp GARS_A PF01071.19 EMC88345.1 - 0.068 12.9 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain WD40 PF00400.32 EMC88348.1 - 8.4e-07 29.6 4.0 0.11 13.4 0.2 3.9 3 1 0 3 3 3 3 WD domain, G-beta repeat WD40_like PF17005.5 EMC88348.1 - 0.14 11.5 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 WD40-like domain TMPIT PF07851.13 EMC88349.1 - 1.6 7.9 2.9 8.1 5.6 0.4 2.4 1 1 2 3 3 3 0 TMPIT-like protein Epiglycanin_TR PF05647.11 EMC88349.1 - 2.1 8.3 42.0 3 7.8 7.6 4.0 1 1 1 3 3 3 0 Tandem-repeating region of mucin, epiglycanin-like Reprolysin PF01421.19 EMC88350.1 - 3.8e-42 144.5 0.9 3.8e-42 144.5 0.9 2.3 3 0 0 3 3 2 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 EMC88350.1 - 1.5e-25 89.9 12.8 1.5e-25 89.9 12.8 3.7 3 2 0 3 3 2 1 ADAM cysteine-rich Pep_M12B_propep PF01562.19 EMC88350.1 - 1.9e-21 76.8 0.0 3.5e-21 75.9 0.0 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide Disintegrin PF00200.23 EMC88350.1 - 2.1e-18 66.9 25.1 2.1e-18 66.9 25.1 4.7 3 1 0 4 4 3 1 Disintegrin Reprolysin_5 PF13688.6 EMC88350.1 - 3.8e-11 43.5 0.5 8.2e-11 42.4 0.5 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EMC88350.1 - 1.1e-08 35.6 0.0 1.8e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EMC88350.1 - 3.9e-06 26.6 0.0 6.5e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EMC88350.1 - 4e-05 23.6 0.4 6.9e-05 22.8 0.4 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.13 EMC88350.1 - 0.00058 20.2 12.0 0.00058 20.2 12.0 6.8 7 2 0 7 7 3 1 EGF-like domain ADAM_CR_2 PF17771.1 EMC88350.1 - 0.012 16.1 1.9 0.012 16.1 1.9 6.8 4 1 2 7 7 4 0 ADAM cysteine-rich domain Peptidase_M10 PF00413.24 EMC88350.1 - 0.024 14.5 0.0 0.037 13.9 0.0 1.2 1 0 0 1 1 1 0 Matrixin RNA_pol_Rpb1_R PF05001.13 EMC88351.1 - 0.12 12.8 6.0 2.2 8.8 0.1 2.8 2 0 0 2 2 2 0 RNA polymerase Rpb1 C-terminal repeat Pentapeptide_4 PF13599.6 EMC88352.1 - 4.1e-12 46.1 0.0 0.00014 22.0 0.0 4.0 1 1 3 4 4 4 4 Pentapeptide repeats (9 copies) Lamprin PF06403.11 EMC88352.1 - 4.6e-07 29.9 48.0 0.091 12.7 3.4 5.8 1 1 4 5 5 5 4 Lamprin PMG PF05287.12 EMC88352.1 - 0.063 13.3 3.1 6.2 6.8 0.4 2.9 1 1 3 4 4 4 0 PMG protein Hydrolase_4 PF12146.8 EMC88353.1 - 1.6e-13 50.5 0.0 2.6e-07 30.1 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMC88353.1 - 1.3e-07 31.6 0.1 0.0071 16.0 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMC88353.1 - 1.6e-07 32.1 0.0 0.00014 22.6 0.0 2.3 1 1 1 2 2 2 2 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EMC88353.1 - 7.6e-07 28.8 0.0 2.6e-05 23.8 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family UPF0227 PF05728.12 EMC88353.1 - 0.00076 19.5 0.0 0.014 15.4 0.0 2.1 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0227) DLH PF01738.18 EMC88353.1 - 0.00086 18.9 0.0 0.0014 18.2 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family DUF818 PF05677.12 EMC88353.1 - 0.0012 17.9 0.1 0.0018 17.3 0.1 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Abhydrolase_5 PF12695.7 EMC88353.1 - 0.0025 17.6 0.0 0.0052 16.6 0.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family FSH1 PF03959.13 EMC88353.1 - 0.0057 16.3 0.0 0.0085 15.8 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Asp2 PF16929.5 EMC88353.1 - 0.0087 15.1 0.0 0.012 14.6 0.0 1.2 1 0 0 1 1 1 1 Accessory Sec system GspB-transporter Abhydrolase_2 PF02230.16 EMC88353.1 - 0.0092 15.8 0.0 0.054 13.3 0.0 2.1 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase PAS_3 PF08447.12 EMC88354.1 - 1.7e-24 85.9 0.0 1.5e-18 66.8 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 EMC88354.1 - 1.9e-23 82.6 0.0 9.7e-14 51.3 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 EMC88354.1 - 1.1e-21 77.1 0.6 1.3e-18 67.2 0.2 3.1 2 1 1 3 3 3 2 PAS domain HLH PF00010.26 EMC88354.1 - 3e-14 52.7 1.2 5.8e-14 51.8 1.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.7 EMC88354.1 - 8.8e-12 45.2 0.0 6.6e-09 36.0 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 EMC88354.1 - 4.2e-05 23.8 0.0 0.13 12.5 0.0 2.7 2 0 0 2 2 2 2 PAS fold PAS_2 PF08446.11 EMC88354.1 - 0.015 16.0 0.0 0.19 12.4 0.0 2.3 2 0 0 2 2 2 0 PAS fold FAA_hydrolase PF01557.18 EMC88355.1 - 6.1e-57 192.8 0.0 8.2e-57 192.4 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 EMC88355.1 - 1.1e-35 122.0 0.0 1.7e-35 121.4 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal zf-A20 PF01754.16 EMC88356.1 - 8.4e-13 48.0 8.7 2.5e-12 46.5 8.7 1.9 1 0 0 1 1 1 1 A20-like zinc finger zf-AN1 PF01428.16 EMC88356.1 - 3.3e-09 36.8 7.5 3.3e-09 36.8 7.5 2.3 3 1 1 4 4 4 1 AN1-like Zinc finger Bcl-2 PF00452.19 EMC88357.1 - 1e-21 77.4 0.1 2e-21 76.5 0.0 1.5 2 0 0 2 2 2 1 Apoptosis regulator proteins, Bcl-2 family 5-FTHF_cyc-lig PF01812.20 EMC88358.1 - 1.1e-48 165.5 0.0 1.2e-48 165.4 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family UPF0258 PF06789.12 EMC88359.1 - 1.5e-60 203.7 0.3 3.4e-60 202.6 0.3 1.6 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0258) RXT2_N PF08595.11 EMC88359.1 - 0.0038 17.3 0.6 0.0038 17.3 0.6 2.1 2 0 0 2 2 2 1 RXT2-like, N-terminal Alveol-reg_P311 PF11092.8 EMC88359.1 - 0.058 13.5 0.0 0.2 11.8 0.0 1.9 1 0 0 1 1 1 0 Neuronal protein 3.1 (p311) Peptidase_M8 PF01457.16 EMC88360.1 - 0.00039 19.2 0.0 0.00054 18.8 0.0 1.1 1 0 0 1 1 1 1 Leishmanolysin Frtz PF11768.8 EMC88360.1 - 0.051 11.9 0.0 0.075 11.3 0.0 1.3 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF1712 PF08217.11 EMC88360.1 - 0.075 11.5 0.1 0.25 9.8 0.0 1.7 1 1 1 2 2 2 0 Fungal domain of unknown function (DUF1712) LVIVD PF08309.11 EMC88360.1 - 0.19 11.1 0.0 0.39 10.1 0.0 1.5 1 0 0 1 1 1 0 LVIVD repeat Perilipin PF03036.16 EMC88361.1 - 1.8e-54 185.3 0.2 2e-54 185.1 0.2 1.0 1 0 0 1 1 1 1 Perilipin family Ras PF00071.22 EMC88362.1 - 2.5e-20 72.7 0.0 3e-20 72.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC88362.1 - 0.00049 20.3 0.0 0.0006 20.0 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC88362.1 - 0.051 13.0 0.0 0.092 12.2 0.0 1.4 1 1 0 1 1 1 0 ADP-ribosylation factor family Kinesin PF00225.23 EMC88363.1 - 5.8e-13 48.5 0.0 5.8e-13 48.5 0.0 2.0 3 0 0 3 3 3 1 Kinesin motor domain SPT16 PF08644.11 EMC88363.1 - 0.0024 18.1 3.8 0.2 11.8 0.1 2.2 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) EzrA PF06160.12 EMC88363.1 - 0.017 13.3 6.6 0.014 13.6 1.5 2.0 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA NPV_P10 PF05531.12 EMC88363.1 - 0.031 14.7 4.1 0.13 12.7 1.2 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein TMPIT PF07851.13 EMC88363.1 - 0.16 11.2 6.5 0.52 9.5 1.2 2.1 2 0 0 2 2 2 0 TMPIT-like protein AAA_13 PF13166.6 EMC88363.1 - 0.18 10.4 9.3 0.76 8.4 2.1 2.1 2 0 0 2 2 2 0 AAA domain Rsd_AlgQ PF04353.13 EMC88363.1 - 0.21 11.5 5.8 0.82 9.6 0.2 2.3 2 0 0 2 2 2 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ FlxA PF14282.6 EMC88363.1 - 0.22 11.5 16.3 0.87 9.6 0.4 2.6 2 1 0 2 2 2 0 FlxA-like protein DUF3450 PF11932.8 EMC88363.1 - 0.32 10.3 13.0 0.3 10.4 4.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) APG6_N PF17675.1 EMC88363.1 - 0.83 10.2 21.8 2.7 8.5 14.8 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region RmuC PF02646.16 EMC88363.1 - 0.84 8.7 8.6 3.3 6.7 0.2 2.3 2 0 0 2 2 2 0 RmuC family Tmemb_cc2 PF10267.9 EMC88363.1 - 0.92 8.6 16.5 3.6 6.6 16.3 1.7 1 1 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DUF948 PF06103.11 EMC88363.1 - 0.92 9.8 2.9 2.3 8.5 0.6 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) CENP-F_leu_zip PF10473.9 EMC88363.1 - 1.1 9.3 19.6 1.5 8.9 10.1 2.7 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 LPP PF04728.13 EMC88363.1 - 1.3 9.4 6.2 3.3 8.2 0.2 3.4 2 1 1 3 3 3 0 Lipoprotein leucine-zipper TSC22 PF01166.18 EMC88363.1 - 1.5 9.2 7.2 20 5.6 0.2 3.1 2 1 0 2 2 2 0 TSC-22/dip/bun family MRP-L28 PF09812.9 EMC88363.1 - 1.5 8.9 8.3 2.5 8.2 1.4 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L28 bZIP_1 PF00170.21 EMC88363.1 - 1.6 8.9 9.7 0.47 10.6 4.1 2.6 2 0 0 2 2 2 0 bZIP transcription factor Histone_HNS PF00816.21 EMC88363.1 - 2.9 8.8 9.2 5.6 7.9 3.6 2.6 2 0 0 2 2 2 0 H-NS histone family CSN5_C PF18323.1 EMC88363.1 - 2.9 8.9 10.6 28 5.7 6.6 2.8 2 1 0 2 2 2 0 Cop9 signalosome subunit 5 C-terminal domain DUF4559 PF15112.6 EMC88363.1 - 3 7.4 10.5 4.8 6.8 5.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) BLOC1_2 PF10046.9 EMC88363.1 - 3.2 8.1 13.8 1.8 8.9 1.5 3.5 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Swi5 PF07061.11 EMC88363.1 - 3.6 7.7 12.7 0.76 9.9 3.8 2.8 3 1 0 3 3 2 0 Swi5 KELK PF15796.5 EMC88363.1 - 5 7.7 17.4 0.31 11.5 6.6 2.6 3 0 0 3 3 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase YlqD PF11068.8 EMC88363.1 - 6 7.3 18.2 0.82 10.1 1.6 2.4 1 1 0 2 2 2 0 YlqD protein FemAB PF02388.16 EMC88363.1 - 6.5 5.5 7.7 13 4.5 2.5 2.1 2 0 0 2 2 2 0 FemAB family MCC-bdg_PDZ PF10506.9 EMC88363.1 - 6.8 6.8 11.9 6.9 6.8 2.1 3.0 3 0 0 3 3 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome GIT_CC PF16559.5 EMC88363.1 - 7.9 6.4 12.9 0.86 9.5 0.2 3.6 4 0 0 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor CREPT PF16566.5 EMC88363.1 - 8.2 6.6 11.8 1.4 9.1 2.2 2.7 3 0 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour Mod_r PF07200.13 EMC88363.1 - 9 6.4 19.2 7.7 6.6 8.2 2.7 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein DUF16 PF01519.16 EMC88363.1 - 9.6 6.7 13.3 9.5 6.8 0.2 3.2 2 1 0 2 2 2 0 Protein of unknown function DUF16 PKHD_C PF18331.1 EMC88364.1 - 0.22 11.6 3.2 0.9 9.7 0.0 3.8 3 0 0 3 3 3 0 PKHD-type hydroxylase C-terminal domain DUF2218 PF09981.9 EMC88364.1 - 1.4 9.3 6.4 1.1 9.6 0.3 3.3 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2218) Treslin_N PF15292.6 EMC88366.1 - 2.2e-267 889.6 7.0 2.4e-267 889.4 7.0 1.0 1 0 0 1 1 1 1 Treslin N-terminus DUF2026 PF09641.10 EMC88366.1 - 0.17 11.5 0.2 0.4 10.3 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2026) DNApol_Exo PF18136.1 EMC88367.1 - 4e-106 354.3 0.0 7.7e-106 353.3 0.0 1.5 1 0 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 EMC88367.1 - 5.1e-60 203.5 0.0 8.4e-60 202.8 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.20 EMC88367.1 - 0.029 14.1 0.1 0.19 11.4 0.1 2.2 1 1 0 1 1 1 0 3'-5' exonuclease FANCI_HD2 PF14680.6 EMC88368.1 - 8.4e-98 326.4 3.3 8.4e-98 326.4 3.3 2.3 2 0 0 2 2 2 1 FANCI helical domain 2 FANCI_S4 PF14678.6 EMC88368.1 - 4.3e-94 314.3 4.5 4.3e-94 314.3 4.5 3.1 5 0 0 5 5 5 1 FANCI solenoid 4 FANCI_S3 PF14677.6 EMC88368.1 - 4.4e-84 281.5 3.3 4.4e-84 281.5 3.3 3.2 4 0 0 4 4 4 1 FANCI solenoid 3 FANCI_S1 PF14675.6 EMC88368.1 - 5.4e-79 264.9 1.8 2.6e-78 262.7 1.8 2.3 1 0 0 1 1 1 1 FANCI solenoid 1 FANCI_S2 PF14676.6 EMC88368.1 - 2.3e-60 203.7 0.2 2.3e-60 203.7 0.2 3.3 3 0 0 3 3 3 1 FANCI solenoid 2 FANCI_HD1 PF14679.6 EMC88368.1 - 3.2e-32 110.3 0.4 1.8e-31 108.0 0.4 2.5 1 0 0 1 1 1 1 FANCI helical domain 1 FANCI_S1-cap PF14674.6 EMC88368.1 - 4.2e-22 78.0 0.6 2.4e-21 75.6 0.6 2.5 1 0 0 1 1 1 1 FANCI solenoid 1 cap CRAL_TRIO PF00650.20 EMC88369.1 - 3.2e-38 131.0 0.0 4.7e-38 130.4 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EMC88369.1 - 8.8e-11 42.1 0.0 2e-10 41.0 0.0 1.6 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EMC88369.1 - 1.7e-07 31.3 0.3 5.7e-07 29.6 0.3 2.0 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain DUF1336 PF07059.12 EMC88369.1 - 0.052 13.6 0.0 0.08 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1336) Spc7 PF08317.11 EMC88369.1 - 0.16 10.9 0.6 0.26 10.1 0.6 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Abhydrolase_1 PF00561.20 EMC88370.1 - 1.2e-25 90.6 0.0 1.6e-25 90.3 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMC88370.1 - 1.2e-10 41.1 0.0 3.4e-10 39.6 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Cutinase PF01083.22 EMC88370.1 - 0.0055 16.7 0.1 0.012 15.5 0.1 1.5 1 1 0 1 1 1 1 Cutinase Ndr PF03096.14 EMC88370.1 - 0.0086 14.8 0.0 0.012 14.3 0.0 1.1 1 0 0 1 1 1 1 Ndr family DUF915 PF06028.11 EMC88370.1 - 0.026 13.9 0.0 0.043 13.1 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Peptidase_S9 PF00326.21 EMC88370.1 - 0.04 13.4 0.1 1.4 8.4 0.0 2.7 2 1 1 3 3 3 0 Prolyl oligopeptidase family VirJ PF06057.11 EMC88370.1 - 0.049 13.5 0.0 0.094 12.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) DUF2637 PF10935.8 EMC88370.1 - 0.049 13.5 0.0 2 8.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2637) Lipase_3 PF01764.25 EMC88370.1 - 0.14 12.0 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Xlink PF00193.17 EMC88371.1 - 9.2e-54 179.8 0.0 2e-33 114.6 0.0 2.4 2 1 0 2 2 2 2 Extracellular link domain V-set PF07686.17 EMC88371.1 - 2.1e-11 43.9 0.0 3.6e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 EMC88371.1 - 6.4e-06 26.3 0.0 1e-05 25.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC88371.1 - 1e-05 26.0 0.0 2.3e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC88371.1 - 7.2e-05 22.8 0.0 0.00013 21.9 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Lectin_C PF00059.21 EMC88371.1 - 0.0023 18.6 0.5 0.54 11.0 0.1 2.4 2 0 0 2 2 2 1 Lectin C-type domain Izumo-Ig PF16706.5 EMC88371.1 - 0.0066 16.5 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 Izumo-like Immunoglobulin domain Ig_2 PF13895.6 EMC88371.1 - 0.057 13.8 0.0 0.49 10.8 0.0 2.1 1 1 0 1 1 1 0 Immunoglobulin domain Xlink PF00193.17 EMC88372.1 - 3.3e-122 399.2 16.9 1.8e-32 111.6 0.5 5.3 5 1 0 5 5 5 4 Extracellular link domain Lectin_C PF00059.21 EMC88372.1 - 3.8e-22 79.1 16.4 1.2e-19 71.0 2.4 5.2 5 0 0 5 5 5 2 Lectin C-type domain V-set PF07686.17 EMC88372.1 - 2.6e-09 37.2 0.0 5.5e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain Sushi PF00084.20 EMC88372.1 - 3.6e-09 37.1 1.3 1.1e-08 35.5 1.3 1.9 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) CTD PF12815.7 EMC88372.1 - 2.9e-07 31.0 26.2 0.069 13.7 0.6 7.1 1 1 6 7 7 7 5 Spt5 C-terminal nonapeptide repeat binding Spt4 EGF PF00008.27 EMC88372.1 - 0.00013 22.2 4.2 0.0005 20.3 4.2 2.1 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 EMC88372.1 - 0.00024 21.6 1.1 0.00024 21.6 1.1 3.0 4 0 0 4 4 4 1 Human growth factor-like EGF EGF_CA PF07645.15 EMC88372.1 - 0.075 13.3 8.8 0.07 13.4 5.9 2.5 2 1 0 2 2 2 0 Calcium-binding EGF domain Pentapeptide_4 PF13599.6 EMC88372.1 - 0.08 13.1 0.0 20 5.4 0.0 3.7 2 1 2 4 4 4 0 Pentapeptide repeats (9 copies) RNase_T PF00929.24 EMC88373.1 - 2.6e-18 67.1 0.0 4.2e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 EMC88373.1 - 4.6e-05 23.2 0.0 0.00012 21.8 0.0 1.6 1 1 0 1 1 1 1 3'-5' exonuclease Det1 PF09737.9 EMC88374.1 - 3.8e-192 638.9 0.8 4.5e-192 638.6 0.8 1.1 1 0 0 1 1 1 1 De-etiolated protein 1 Det1 NtCtMGAM_N PF16863.5 EMC88374.1 - 0.024 14.8 0.2 1.5 9.0 0.1 2.6 2 0 0 2 2 2 0 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Ribosomal_S11 PF00411.19 EMC88375.1 - 1.6e-28 99.3 2.6 1.9e-28 99.1 2.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S11 MRP-L46 PF11788.8 EMC88376.1 - 0.0003 21.5 2.6 0.00062 20.5 2.6 1.5 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 NUDIX PF00293.28 EMC88376.1 - 0.013 15.5 0.1 0.03 14.4 0.0 1.6 2 0 0 2 2 2 0 NUDIX domain Pkinase_Tyr PF07714.17 EMC88377.1 - 1.8e-90 302.7 0.5 4.5e-88 294.9 0.5 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC88377.1 - 7.1e-44 150.1 0.0 1.3e-43 149.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain TPKR_C2 PF16920.5 EMC88377.1 - 1.1e-19 70.2 7.1 3.5e-19 68.6 7.1 2.0 1 0 0 1 1 1 1 Tyrosine-protein kinase receptor C2 Ig-like domain I-set PF07679.16 EMC88377.1 - 8.7e-19 67.4 0.0 1.3e-09 38.0 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC88377.1 - 3.5e-17 62.8 0.4 3.4e-09 37.2 0.5 2.7 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 EMC88377.1 - 3.4e-16 59.2 0.5 1e-12 48.0 0.2 2.4 2 0 0 2 2 2 2 Immunoglobulin domain LRR_8 PF13855.6 EMC88377.1 - 2.2e-12 46.5 1.6 2.2e-12 46.5 1.6 2.2 2 0 0 2 2 2 1 Leucine rich repeat Ig_2 PF13895.6 EMC88377.1 - 7.5e-12 45.4 0.7 6.4e-07 29.6 0.2 2.4 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 EMC88377.1 - 5.7e-06 26.3 0.1 0.024 14.7 0.1 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain LRR_4 PF12799.7 EMC88377.1 - 0.00034 20.9 4.0 0.0017 18.7 0.7 2.9 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) LRRNT PF01462.18 EMC88377.1 - 0.00044 19.8 1.9 0.00044 19.8 1.9 2.0 2 0 0 2 2 1 1 Leucine rich repeat N-terminal domain LRR_5 PF13306.6 EMC88377.1 - 0.0045 16.9 0.0 0.013 15.4 0.0 1.8 1 1 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) TrkA_TMD PF18613.1 EMC88377.1 - 0.0082 15.5 11.6 0.022 14.2 11.6 1.8 1 0 0 1 1 1 1 Tyrosine kinase receptor A trans-membrane domain LRR_6 PF13516.6 EMC88377.1 - 0.047 13.7 0.1 0.17 12.0 0.1 2.0 1 0 0 1 1 1 0 Leucine Rich repeat Haspin_kinase PF12330.8 EMC88377.1 - 0.061 12.3 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain LRR_1 PF00560.33 EMC88377.1 - 2.8 8.8 9.4 1.5 9.6 0.1 4.3 5 0 0 5 5 3 0 Leucine Rich Repeat Pepdidase_M14_N PF18027.1 EMC88378.1 - 6.9e-11 42.5 0.2 1.6e-10 41.3 0.2 1.7 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain Peptidase_M14 PF00246.24 EMC88378.1 - 1.2e-10 41.7 0.0 2.3e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 Zinc carboxypeptidase Neurochondrin PF05536.11 EMC88378.1 - 0.033 12.6 0.0 0.052 11.9 0.0 1.2 1 0 0 1 1 1 0 Neurochondrin AstE_AspA PF04952.14 EMC88378.1 - 0.048 12.7 0.0 0.073 12.1 0.0 1.3 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family Kelch_1 PF01344.25 EMC88379.1 - 1.5e-48 162.1 8.8 2e-11 43.3 0.1 6.0 6 1 0 6 6 6 5 Kelch motif BACK PF07707.15 EMC88379.1 - 1.6e-33 114.9 3.5 1.8e-33 114.7 2.0 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_6 PF13964.6 EMC88379.1 - 6.9e-29 99.2 3.2 4.3e-06 26.8 0.0 6.2 3 2 3 6 6 6 5 Kelch motif Kelch_3 PF13415.6 EMC88379.1 - 6.4e-28 96.5 1.8 9.4e-06 25.8 0.0 6.3 6 1 0 6 6 6 5 Galactose oxidase, central domain BTB PF00651.31 EMC88379.1 - 3.3e-26 91.7 0.2 7.1e-26 90.6 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 EMC88379.1 - 1.3e-23 82.0 4.6 0.00019 21.3 0.1 6.3 5 1 0 5 5 5 5 Kelch motif Kelch_4 PF13418.6 EMC88379.1 - 1e-22 79.9 0.9 6.8e-08 32.4 0.0 5.6 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC88379.1 - 9.1e-13 47.9 5.3 1.3e-06 28.3 0.0 5.3 5 0 0 5 5 5 2 Kelch motif DUF1668 PF07893.13 EMC88379.1 - 0.0074 15.7 0.2 0.036 13.4 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1668) DUF3342 PF11822.8 EMC88379.1 - 0.0084 16.3 0.0 0.035 14.3 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3342) Root_cap PF06830.11 EMC88379.1 - 0.17 12.0 0.0 0.43 10.7 0.0 1.7 1 0 0 1 1 1 0 Root cap OATP PF03137.20 EMC88380.1 - 2.6e-175 583.8 7.7 3.1e-175 583.6 7.7 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 EMC88380.1 - 4.1e-26 91.7 9.1 4.1e-26 91.7 9.1 2.9 2 2 0 2 2 2 2 Major Facilitator Superfamily Kazal_2 PF07648.15 EMC88380.1 - 7.9e-07 29.1 14.0 1.3e-06 28.4 10.3 2.5 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EMC88380.1 - 0.01 15.8 8.8 0.049 13.7 8.8 2.1 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain PUCC PF03209.15 EMC88380.1 - 0.21 10.6 13.6 0.27 10.2 0.1 3.8 4 0 0 4 4 4 0 PUCC protein D_CNTX PF17492.2 EMC88380.1 - 1.8 8.8 0.0 1.8 8.8 0.0 3.4 4 0 0 4 4 4 0 Delta Ctenitoxins DUF1180 PF06679.12 EMC88381.1 - 3.8e-19 69.7 0.5 4.2e-19 69.6 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) SNF2_N PF00176.23 EMC88383.1 - 8.3e-67 225.4 0.5 1.6e-66 224.4 0.5 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain CDH1_2_SANT_HL1 PF18375.1 EMC88383.1 - 6.3e-34 116.5 0.0 6.3e-34 116.5 0.0 5.7 5 0 0 5 5 5 1 CDH1/2 SANT-Helical linker 1 Chromo PF00385.24 EMC88383.1 - 2.5e-32 110.6 10.9 2.4e-21 75.4 0.0 3.9 3 1 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain DUF4208 PF13907.6 EMC88383.1 - 4e-25 88.1 0.9 4e-25 88.1 0.9 3.5 4 0 0 4 4 4 1 Domain of unknown function (DUF4208) Helicase_C PF00271.31 EMC88383.1 - 1.4e-19 70.5 0.1 5.7e-19 68.5 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC88383.1 - 2.5e-08 34.1 0.0 2.5e-08 34.1 0.0 3.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit CHDCT2 PF08074.11 EMC88383.1 - 0.00034 20.8 0.0 0.021 15.0 0.0 3.3 2 0 0 2 2 2 1 CHDCT2 (NUC038) domain Myb_DNA-binding PF00249.31 EMC88383.1 - 0.0025 17.9 0.1 0.05 13.8 0.1 2.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain SLIDE PF09111.10 EMC88383.1 - 0.0047 16.9 0.1 0.0047 16.9 0.1 3.6 3 1 0 3 3 3 1 SLIDE RGM_C PF06534.13 EMC88384.1 - 3.9e-73 244.6 0.0 5.6e-73 244.1 0.0 1.2 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) C-terminus RGM_N PF06535.12 EMC88384.1 - 3.3e-72 242.1 1.6 4.9e-72 241.5 1.6 1.3 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) N-terminus C8 PF08742.11 EMC88384.1 - 1 9.8 5.5 2.7 8.5 0.0 3.0 3 0 0 3 3 3 0 C8 domain C2 PF00168.30 EMC88386.1 - 4.6e-35 120.0 0.1 8.8e-21 74.1 0.1 2.2 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.6 EMC88386.1 - 0.012 15.2 0.0 0.036 13.6 0.0 2.0 2 1 0 2 2 2 0 CEP76 C2 domain DOCK-C2 PF14429.6 EMC88386.1 - 0.064 13.1 0.0 1.5 8.6 0.0 2.1 2 0 0 2 2 2 0 C2 domain in Dock180 and Zizimin proteins Cadherin PF00028.17 EMC88387.1 - 5.6e-82 270.3 5.9 1.8e-18 66.8 0.1 5.2 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 EMC88387.1 - 2.1e-54 183.8 1.9 4.1e-54 182.9 0.9 2.0 2 0 0 2 2 2 1 Cadherin cytoplasmic region Cadherin_3 PF16184.5 EMC88387.1 - 2e-11 43.9 3.1 0.0058 16.6 0.0 5.2 5 0 0 5 5 5 4 Cadherin-like Cadherin_2 PF08266.12 EMC88387.1 - 5e-05 23.0 0.0 1.1 9.1 0.0 4.4 4 0 0 4 4 4 1 Cadherin-like Invasin_D3 PF09134.10 EMC88387.1 - 0.017 15.4 5.5 14 6.0 0.0 4.7 3 1 1 4 4 4 0 Invasin, domain 3 ASFV_J13L PF05568.11 EMC88387.1 - 0.059 13.1 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 African swine fever virus J13L protein He_PIG PF05345.12 EMC88387.1 - 1.5 9.0 4.5 66 3.8 0.1 4.5 4 0 0 4 4 4 0 Putative Ig domain Cadherin_4 PF17803.1 EMC88387.1 - 6.6 7.4 16.8 0.051 14.2 1.3 4.2 4 0 0 4 4 4 0 Bacterial cadherin-like domain OSK PF17182.4 EMC88388.1 - 0.028 13.7 0.0 0.047 12.9 0.0 1.3 1 0 0 1 1 1 0 OSK domain BASP1 PF05466.12 EMC88391.1 - 1.2e-95 320.0 97.1 1.4e-95 319.9 97.1 1.0 1 0 0 1 1 1 1 Brain acid soluble protein 1 (BASP1 protein) TILa PF12714.7 EMC88392.1 - 1.5e-14 53.7 108.4 0.027 14.4 2.9 11.0 6 5 5 11 11 11 11 TILa domain CBM_1 PF00734.18 EMC88392.1 - 3.5e-11 42.8 65.6 0.27 11.2 0.5 12.0 12 0 0 12 12 12 11 Fungal cellulose binding domain FOLN PF09289.10 EMC88392.1 - 1.5e-05 25.1 104.2 0.015 15.5 3.7 12.6 11 2 1 12 12 12 7 Follistatin/Osteonectin-like EGF domain zf_CCCH_4 PF18345.1 EMC88392.1 - 0.47 10.6 37.9 75 3.6 0.1 11.3 11 0 0 11 11 11 0 Zinc finger domain TILa PF12714.7 EMC88393.1 - 1.5e-16 60.1 112.3 0.019 14.9 3.9 11.0 6 5 5 11 11 11 10 TILa domain FOLN PF09289.10 EMC88393.1 - 1.1e-10 41.5 111.8 0.00028 21.0 4.9 11.4 11 0 0 11 11 11 9 Follistatin/Osteonectin-like EGF domain CBM_1 PF00734.18 EMC88393.1 - 3.8e-07 30.0 64.6 0.062 13.3 1.2 11.4 10 1 0 10 10 10 7 Fungal cellulose binding domain Dicty_spore_N PF04562.12 EMC88393.1 - 3.1 8.5 78.4 0.31 11.8 7.7 6.3 1 1 4 5 5 5 0 Dictyostelium spore coat protein, N terminus zf-C3HC4_2 PF13923.6 EMC88394.1 - 3e-08 33.4 9.2 3e-08 33.4 9.2 2.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMC88394.1 - 1.5e-07 31.2 7.7 1.5e-07 31.2 7.7 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC88394.1 - 8.6e-07 28.7 9.2 8.6e-07 28.7 9.2 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC88394.1 - 3.5e-06 27.3 9.7 3.5e-06 27.3 9.7 2.6 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 EMC88394.1 - 5.8e-06 26.2 8.6 5.8e-06 26.2 8.6 2.3 3 0 0 3 3 3 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC88394.1 - 4e-05 23.4 9.9 0.00084 19.2 10.4 2.6 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EMC88394.1 - 5.2e-05 23.5 6.8 5.2e-05 23.5 6.8 2.6 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EMC88394.1 - 0.0013 18.7 8.7 0.0013 18.7 8.7 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EMC88394.1 - 0.064 13.3 10.2 0.049 13.7 4.2 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 EMC88394.1 - 0.065 13.4 3.0 0.15 12.2 3.0 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-C3HC4_4 PF15227.6 EMC88394.1 - 0.16 12.2 12.9 0.056 13.6 9.2 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EMC88394.1 - 0.31 10.9 6.4 1.3 8.9 6.4 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain SRCR PF00530.18 EMC88395.1 - 7.4e-116 379.4 39.4 8.7e-32 109.6 4.5 4.3 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 EMC88395.1 - 1.8e-13 50.8 19.4 0.0038 17.7 0.9 4.4 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 EMC88395.1 - 0.00039 20.9 6.1 2.6 8.6 0.1 4.3 4 0 0 4 4 4 3 Hepsin, SRCR domain zf-H2C2_2 PF13465.6 EMC88396.1 - 8.8e-55 180.8 41.1 9.1e-11 41.7 1.0 6.7 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.26 EMC88396.1 - 4e-37 124.6 43.8 2e-07 31.1 0.4 7.1 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC88396.1 - 2.4e-21 74.6 44.2 0.00034 21.2 0.5 7.1 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC88396.1 - 1.9e-12 47.1 14.0 0.0051 17.1 0.0 6.4 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 EMC88396.1 - 1.6e-07 31.3 21.7 0.032 14.3 3.4 4.8 2 2 3 5 5 5 5 Zinc ribbon domain Zn_ribbon_SprT PF17283.2 EMC88396.1 - 2.2e-06 27.5 31.4 0.011 15.7 1.7 4.8 5 0 0 5 5 4 3 SprT-like zinc ribbon domain zf_UBZ PF18439.1 EMC88396.1 - 4.1e-06 26.3 20.4 0.1 12.2 0.0 6.6 7 0 0 7 7 7 2 Ubiquitin-Binding Zinc Finger DUF3268 PF11672.8 EMC88396.1 - 1.2e-05 25.6 12.4 0.41 11.0 0.4 4.0 3 1 1 4 4 4 3 zinc-finger-containing domain zf-Di19 PF05605.12 EMC88396.1 - 1.7e-05 25.0 25.0 0.24 11.7 3.8 4.9 2 1 0 4 4 4 3 Drought induced 19 protein (Di19), zinc-binding DZR PF12773.7 EMC88396.1 - 1.9e-05 24.6 25.4 0.064 13.3 4.7 3.5 2 2 1 3 3 3 3 Double zinc ribbon zinc_ribbon_15 PF17032.5 EMC88396.1 - 3.3e-05 24.5 10.5 0.37 11.6 0.3 3.5 2 1 1 3 3 3 3 zinc-ribbon family zf-LYAR PF08790.11 EMC88396.1 - 8.7e-05 22.3 16.8 6.4 6.8 0.3 6.9 7 0 0 7 7 7 0 LYAR-type C2HC zinc finger zf-trcl PF13451.6 EMC88396.1 - 0.00048 20.0 23.1 0.013 15.4 3.6 5.2 5 1 0 5 5 5 1 Probable zinc-ribbon domain HypA PF01155.19 EMC88396.1 - 0.00058 19.8 13.6 0.6 10.1 1.0 3.4 1 1 2 3 3 3 3 Hydrogenase/urease nickel incorporation, metallochaperone, hypA XPA_N PF01286.18 EMC88396.1 - 0.00075 19.5 17.1 0.54 10.3 0.0 6.6 7 0 0 7 7 7 1 XPA protein N-terminal C1_1 PF00130.22 EMC88396.1 - 0.001 18.9 18.1 0.033 14.1 0.3 5.0 1 1 3 4 4 4 1 Phorbol esters/diacylglycerol binding domain (C1 domain) FYDLN_acid PF09538.10 EMC88396.1 - 0.001 19.7 16.5 1 10.1 0.1 5.3 1 1 4 5 5 5 1 Protein of unknown function (FYDLN_acid) Ogr_Delta PF04606.12 EMC88396.1 - 0.001 19.0 1.3 0.001 19.0 1.3 4.7 3 2 0 4 4 3 1 Ogr/Delta-like zinc finger CpXC PF14353.6 EMC88396.1 - 0.0021 18.1 24.1 1.6 8.8 0.1 6.0 4 2 2 6 6 6 1 CpXC protein BolA PF01722.18 EMC88396.1 - 0.0022 18.2 2.9 8.3 6.8 0.0 3.9 1 1 2 3 3 3 0 BolA-like protein C1_4 PF07975.12 EMC88396.1 - 0.007 16.6 18.4 1 9.6 0.8 4.3 2 1 3 5 5 5 1 TFIIH C1-like domain zf-C2H2_6 PF13912.6 EMC88396.1 - 0.0089 16.0 41.6 0.32 11.0 0.5 7.9 8 1 0 8 8 8 3 C2H2-type zinc finger zinc_ribbon_9 PF14369.6 EMC88396.1 - 0.014 15.6 20.1 0.54 10.6 0.1 5.6 6 0 0 6 6 6 0 zinc-ribbon zf-HIT PF04438.16 EMC88396.1 - 0.026 14.4 27.3 5 7.1 0.2 6.0 6 0 0 6 6 6 0 HIT zinc finger GAGA PF09237.11 EMC88396.1 - 0.042 13.7 23.5 0.052 13.4 2.9 5.0 2 2 3 5 5 5 0 GAGA factor RNA_POL_M_15KD PF02150.16 EMC88396.1 - 0.044 13.7 12.2 0.67 9.9 0.5 5.1 5 1 1 6 6 6 0 RNA polymerases M/15 Kd subunit YacG PF03884.14 EMC88396.1 - 0.084 12.6 17.5 6.2 6.6 0.1 6.2 7 0 0 7 7 7 0 DNA gyrase inhibitor YacG zinc-ribbons_6 PF07191.12 EMC88396.1 - 0.11 12.5 19.6 0.97 9.5 1.4 4.3 1 1 1 2 2 1 0 zinc-ribbons zinc_ribbon_5 PF13719.6 EMC88396.1 - 0.13 12.1 26.4 2.8 7.8 0.1 6.1 7 0 0 7 7 6 0 zinc-ribbon domain zf-C2H2_11 PF16622.5 EMC88396.1 - 0.13 12.0 25.3 0.45 10.3 0.5 6.0 6 0 0 6 6 6 0 zinc-finger C2H2-type Lar_restr_allev PF14354.6 EMC88396.1 - 0.14 12.5 0.6 0.14 12.5 0.6 3.8 2 1 1 3 3 2 0 Restriction alleviation protein Lar zf-AN1 PF01428.16 EMC88396.1 - 0.2 11.9 24.3 7.8 6.7 0.1 6.1 5 1 1 6 6 6 0 AN1-like Zinc finger zf-met PF12874.7 EMC88396.1 - 0.22 11.9 25.9 1.6 9.3 0.3 6.2 6 0 0 6 6 6 0 Zinc-finger of C2H2 type FdhE PF04216.12 EMC88396.1 - 0.65 9.8 17.9 0.13 12.2 0.6 3.7 1 1 3 4 4 4 0 Protein involved in formate dehydrogenase formation DUF2256 PF10013.9 EMC88396.1 - 1 9.5 25.1 2.2 8.5 0.1 6.6 7 0 0 7 7 7 0 Uncharacterized protein conserved in bacteria (DUF2256) YhfH PF14149.6 EMC88396.1 - 2.8 8.0 16.9 23 5.0 0.0 5.8 7 0 0 7 7 7 0 YhfH-like protein zf-C2H2_2 PF12756.7 EMC88396.1 - 3.4 8.1 20.0 12 6.3 0.3 5.3 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) LIM PF00412.22 EMC88396.1 - 8 6.8 19.8 2.7 8.3 2.2 4.9 1 1 3 5 5 5 0 LIM domain TRAF6_Z2 PF18048.1 EMC88396.1 - 9.9 6.4 29.4 0.42 10.8 0.6 5.9 6 0 0 6 6 5 0 TNF receptor-associated factor 6 zinc finger 2 Trypsin PF00089.26 EMC88397.1 - 4.5e-43 147.6 0.1 5e-43 147.5 0.1 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 EMC88397.1 - 0.00011 22.6 0.2 0.00016 22.0 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 EMC88397.1 - 0.002 19.0 0.1 0.0029 18.5 0.1 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Annexin PF00191.20 EMC88398.1 - 3.1e-65 216.2 8.7 4.9e-23 81.0 0.3 3.8 4 0 0 4 4 4 3 Annexin Myb_DNA-bind_7 PF15963.5 EMC88398.1 - 0.0011 18.8 1.1 1.3 9.0 0.0 3.3 2 1 1 3 3 3 2 Myb DNA-binding like Phage_TAC_5 PF08890.11 EMC88398.1 - 0.039 14.0 5.1 0.081 12.9 0.1 2.9 2 1 1 3 3 3 0 Phage XkdN-like tail assembly chaperone protein, TAC Annexin PF00191.20 EMC88399.1 - 3.9e-83 273.5 11.6 5.5e-23 80.8 0.3 4.0 4 0 0 4 4 4 4 Annexin Phage_TAC_5 PF08890.11 EMC88399.1 - 0.00054 20.0 5.2 0.018 15.0 0.2 3.2 1 1 2 3 3 3 2 Phage XkdN-like tail assembly chaperone protein, TAC Myb_DNA-bind_7 PF15963.5 EMC88399.1 - 0.026 14.4 6.2 0.18 11.7 0.1 3.5 3 1 1 4 4 4 0 Myb DNA-binding like TPR_2 PF07719.17 EMC88399.1 - 0.044 13.9 1.7 6.9 7.1 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF2150 PF09920.9 EMC88399.1 - 0.09 12.8 0.7 3.6 7.5 0.1 2.4 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2150) Imm49 PF15575.6 EMC88399.1 - 0.14 11.9 0.4 0.24 11.1 0.4 1.5 1 1 0 1 1 1 0 Immunity protein 49 zf-A20 PF01754.16 EMC88400.1 - 8.2e-13 48.0 8.7 2.6e-12 46.4 8.7 2.0 1 0 0 1 1 1 1 A20-like zinc finger zf-AN1 PF01428.16 EMC88400.1 - 3.9e-09 36.5 7.2 3.9e-09 36.5 7.2 1.9 2 0 0 2 2 2 1 AN1-like Zinc finger Amidohydro_1 PF01979.20 EMC88401.1 - 1.5e-68 231.6 0.0 1.8e-68 231.4 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EMC88401.1 - 1.2e-11 44.8 0.0 2.7e-09 37.1 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family DUF3466 PF11949.8 EMC88401.1 - 0.16 10.6 0.1 0.23 10.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3466) DUF2039 PF10217.9 EMC88402.1 - 1.3e-24 86.3 11.6 1.5e-24 86.2 11.6 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) Cript PF10235.9 EMC88402.1 - 0.00083 19.9 7.0 0.00083 19.9 7.0 1.7 1 1 1 2 2 2 1 Microtubule-associated protein CRIPT zinc-ribbons_6 PF07191.12 EMC88402.1 - 0.0017 18.3 8.3 0.0026 17.7 8.3 1.2 1 0 0 1 1 1 1 zinc-ribbons DZR PF12773.7 EMC88402.1 - 0.2 11.7 9.6 14 5.8 9.6 2.4 1 1 0 1 1 1 0 Double zinc ribbon Hydrolase_4 PF12146.8 EMC88403.1 - 3.7e-13 49.3 0.0 3.8e-07 29.6 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EMC88403.1 - 6.7e-08 33.4 0.0 4.1e-05 24.3 0.0 2.2 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EMC88403.1 - 9.4e-08 32.0 0.1 0.0027 17.4 0.1 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EMC88403.1 - 1.2e-07 31.4 0.0 1.6e-05 24.5 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 EMC88403.1 - 0.0013 18.4 0.0 0.002 17.7 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family UPF0227 PF05728.12 EMC88403.1 - 0.0022 18.0 0.0 0.054 13.4 0.0 2.1 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0227) FSH1 PF03959.13 EMC88403.1 - 0.0036 17.0 0.0 0.0055 16.4 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Asp2 PF16929.5 EMC88403.1 - 0.0044 16.1 0.0 0.0063 15.5 0.0 1.2 1 0 0 1 1 1 1 Accessory Sec system GspB-transporter Abhydrolase_5 PF12695.7 EMC88403.1 - 0.0044 16.8 0.0 0.012 15.4 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF818 PF05677.12 EMC88403.1 - 0.0046 16.0 0.1 0.0064 15.5 0.1 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Abhydrolase_2 PF02230.16 EMC88403.1 - 0.026 14.3 0.0 0.26 11.1 0.0 2.2 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase ILEI PF15711.5 EMC88404.1 - 2.6e-37 127.2 0.0 2.1e-20 73.0 0.0 3.4 3 0 0 3 3 3 2 Interleukin-like EMT inducer G8 PF10162.9 EMC88404.1 - 1.6e-26 92.8 0.0 3.6e-26 91.7 0.0 1.6 1 0 0 1 1 1 1 G8 domain PADR1 PF08063.12 EMC88404.1 - 0.096 12.5 0.7 12 5.7 0.1 2.9 2 0 0 2 2 2 0 PADR1 (NUC008) domain LSDAT_euk PF18139.1 EMC88405.1 - 7.4e-127 422.3 0.1 1.1e-126 421.7 0.1 1.3 1 0 0 1 1 1 1 SLOG in TRPM TRPM_tetra PF16519.5 EMC88405.1 - 3.9e-24 84.5 6.1 1e-23 83.2 6.1 1.8 1 0 0 1 1 1 1 Tetramerisation domain of TRPM Ion_trans PF00520.31 EMC88405.1 - 3.8e-18 65.6 17.1 6.1e-18 65.0 17.1 1.3 1 0 0 1 1 1 1 Ion transport protein LSDAT_prok PF18171.1 EMC88405.1 - 9.1e-18 64.2 0.1 1.6e-17 63.5 0.1 1.3 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote zf-C2H2 PF00096.26 EMC88406.1 - 8.5e-13 48.0 12.1 3.5e-06 27.1 1.1 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC88406.1 - 2.6e-09 37.1 19.2 3e-09 36.9 2.2 3.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC88406.1 - 1.2e-08 35.1 10.2 0.00014 22.4 2.8 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger FOXP-CC PF16159.5 EMC88406.1 - 1.8e-05 25.2 1.8 0.0022 18.6 0.3 2.0 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 EMC88406.1 - 5.8e-05 23.0 3.5 0.02 14.9 0.9 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC88406.1 - 0.0013 19.0 1.3 0.15 12.4 0.2 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC88406.1 - 0.0024 18.2 1.8 0.11 12.9 0.3 2.4 1 1 2 3 3 3 1 Zinc-finger of C2H2 type zf-Di19 PF05605.12 EMC88406.1 - 0.0047 17.2 2.8 0.0074 16.6 2.8 1.4 1 1 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.5 EMC88406.1 - 0.01 16.1 1.4 0.011 16.0 1.4 1.0 1 0 0 1 1 1 1 C2H2-type zinc ribbon zf-C2H2_9 PF16293.5 EMC88406.1 - 0.041 13.7 0.3 0.8 9.6 0.1 2.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (1 copy) zf-LYAR PF08790.11 EMC88406.1 - 0.057 13.3 2.8 2.5 8.1 0.4 2.6 2 1 0 2 2 2 0 LYAR-type C2HC zinc finger Rad50_zn_hook PF04423.14 EMC88406.1 - 0.087 12.7 1.0 0.2 11.5 1.0 1.8 1 1 1 2 2 2 0 Rad50 zinc hook motif Zn-C2H2_12 PF18112.1 EMC88406.1 - 0.28 11.7 4.1 0.49 10.9 1.8 2.4 2 1 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain MAM PF00629.23 EMC88407.1 - 5.5e-132 436.0 0.0 3.7e-43 147.2 0.0 4.0 4 0 0 4 4 4 4 MAM domain, meprin/A5/mu CBM_4_9 PF02018.17 EMC88407.1 - 0.24 11.7 1.0 2.4 8.4 0.0 2.8 3 0 0 3 3 3 0 Carbohydrate binding domain Melibiase_2 PF16499.5 EMC88409.1 - 0.045 12.9 1.8 19 4.3 0.0 3.3 1 1 2 4 4 4 0 Alpha galactosidase A CDCA PF18484.1 EMC88409.1 - 3.9 7.3 9.3 11 5.8 0.2 4.8 1 1 5 6 6 6 0 Cadmium carbonic anhydrase repeat Pkinase_C PF00433.24 EMC88410.1 - 7.6e-10 39.3 2.3 1.1e-09 38.8 2.3 1.2 1 0 0 1 1 1 1 Protein kinase C terminal domain MA3 PF02847.17 EMC88411.1 - 2.2e-14 53.4 0.6 3.6e-14 52.7 0.6 1.4 1 0 0 1 1 1 1 MA3 domain AF-4 PF05110.13 EMC88411.1 - 0.2 9.7 75.5 0.25 9.4 75.5 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein zf-met PF12874.7 EMC88412.1 - 8.3e-29 99.1 25.2 1.2e-07 31.9 1.9 4.3 4 0 0 4 4 4 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMC88412.1 - 2e-22 78.9 20.7 2.9e-06 27.4 3.0 4.3 4 0 0 4 4 4 4 Zinc-finger double-stranded RNA-binding zf-U1 PF06220.12 EMC88412.1 - 1.9e-09 37.1 12.2 0.015 15.0 0.0 4.3 4 0 0 4 4 4 4 U1 zinc finger zf-C2H2_2 PF12756.7 EMC88412.1 - 2e-09 37.7 10.9 0.15 12.5 0.4 4.2 4 0 0 4 4 4 4 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.12 EMC88412.1 - 1.5e-06 28.6 6.8 0.18 12.0 0.1 4.1 4 0 0 4 4 4 2 A-kinase anchoring protein 95 (AKAP95) DUF3449 PF11931.8 EMC88412.1 - 0.0091 15.8 1.9 7.3 6.3 0.0 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF3449) zf-DBF PF07535.12 EMC88412.1 - 0.01 15.9 13.8 0.19 11.9 0.8 4.3 4 0 0 4 4 4 0 DBF zinc finger zf-C2H2 PF00096.26 EMC88412.1 - 0.016 15.7 12.4 5 7.8 1.4 4.4 4 0 0 4 4 4 0 Zinc finger, C2H2 type UPF0728 PF15092.6 EMC88412.1 - 0.089 12.6 0.1 1.1 9.2 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0728 zf-C2H2_9 PF16293.5 EMC88412.1 - 0.21 11.4 8.4 28 4.6 0.3 4.2 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-C2H2_4 PF13894.6 EMC88412.1 - 0.24 12.3 9.9 11 7.2 0.4 4.4 4 0 0 4 4 4 0 C2H2-type zinc finger zf-piccolo PF05715.13 EMC88412.1 - 0.36 11.0 6.5 20 5.4 0.1 4.1 4 0 0 4 4 4 0 Piccolo Zn-finger zinc_ribbon_15 PF17032.5 EMC88412.1 - 0.55 11.0 8.3 5.6 7.8 0.3 3.5 3 1 0 3 3 3 0 zinc-ribbon family zf-RING_7 PF02591.15 EMC88412.1 - 0.58 10.4 3.2 7.9 6.8 0.1 3.7 4 0 0 4 4 4 0 C4-type zinc ribbon domain C1_1 PF00130.22 EMC88412.1 - 0.65 9.9 3.8 20 5.2 0.0 3.7 4 0 0 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) IBR PF01485.21 EMC88412.1 - 0.99 9.7 5.2 8.2 6.7 0.0 3.4 3 1 0 3 3 3 0 IBR domain, a half RING-finger domain zf_C2H2_ZHX PF18387.1 EMC88412.1 - 1.9 8.2 10.0 1.3 8.8 0.4 2.9 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain Actin_micro PF17003.5 EMC88412.1 - 3.9 6.5 14.8 1.8 7.7 0.3 3.5 3 1 0 3 3 3 0 Putative actin-like family CRAL_TRIO_2 PF13716.6 EMC88413.1 - 1.1e-07 32.1 0.1 2.3e-07 31.0 0.1 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Spectrin PF00435.21 EMC88413.1 - 1.5e-05 25.5 21.5 0.00035 21.0 0.4 4.3 3 1 1 4 4 4 2 Spectrin repeat MatP PF06303.12 EMC88413.1 - 0.07 13.7 3.1 1 9.9 0.9 2.9 2 0 0 2 2 2 0 MatP N-terminal domain PH PF00169.29 EMC88414.1 - 3.3e-10 40.4 0.0 7e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EMC88414.1 - 1.3e-05 25.6 0.3 0.00011 22.5 0.1 2.6 2 1 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 EMC88414.1 - 1.4e-05 25.3 0.0 3.9e-05 23.9 0.0 1.7 2 0 0 2 2 2 1 Pleckstrin homology domain Muted PF14942.6 EMC88414.1 - 0.022 15.1 0.5 0.051 13.9 0.5 1.5 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Cmc1 PF08583.10 EMC88414.1 - 0.066 13.2 1.6 4.7 7.3 0.1 2.5 2 0 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like DUF5327 PF17261.2 EMC88414.1 - 0.1 13.4 2.4 0.29 11.9 0.3 2.3 2 1 0 2 2 2 0 Family of unknown function (DUF5327) PH_6 PF15406.6 EMC88414.1 - 0.1 12.9 0.0 0.41 11.0 0.0 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain Gasdermin PF04598.12 EMC88415.1 - 2.1e-40 138.7 0.0 2.8e-40 138.3 0.0 1.2 1 0 0 1 1 1 1 Gasdermin pore forming domain Oxysterol_BP PF01237.18 EMC88416.1 - 2.4e-126 421.5 4.1 2.4e-126 421.5 4.1 2.9 2 1 0 2 2 2 1 Oxysterol-binding protein PH_8 PF15409.6 EMC88416.1 - 3.3e-13 49.7 0.4 7.6e-13 48.6 0.4 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EMC88416.1 - 4e-07 30.5 0.8 1.2e-06 28.9 0.8 1.9 1 0 0 1 1 1 1 PH domain tRNA_bind_3 PF17176.4 EMC88416.1 - 0.11 12.8 0.6 0.32 11.3 0.6 1.7 1 0 0 1 1 1 0 tRNA-binding domain PH_11 PF15413.6 EMC88416.1 - 1.1 9.8 3.7 74 3.8 3.7 3.0 1 1 0 1 1 1 0 Pleckstrin homology domain GAF PF01590.26 EMC88417.1 - 1.7e-36 125.8 0.0 3.3e-17 63.4 0.0 2.2 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.6 EMC88417.1 - 2.4e-13 50.6 0.0 3.5e-06 27.4 0.0 2.5 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.6 EMC88417.1 - 5.1e-11 43.0 0.0 2.7e-06 27.7 0.0 4.1 3 1 0 3 3 3 2 GAF domain PDEase_I PF00233.19 EMC88417.1 - 0.00015 21.6 2.7 0.0016 18.3 1.6 2.2 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase dCache_1 PF02743.18 EMC88417.1 - 0.026 14.3 0.0 4.2 7.1 0.0 2.2 2 0 0 2 2 2 0 Cache domain WTX PF09422.10 EMC88418.1 - 1.5e-32 113.3 16.2 1.5e-32 113.3 16.2 3.0 2 1 0 2 2 2 1 WTX protein 7tm_1 PF00001.21 EMC88419.1 - 1.9e-05 24.1 22.2 4.5e-05 22.9 22.2 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC88419.1 - 0.00051 19.8 4.7 0.00051 19.8 4.7 2.3 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 EMC88419.1 - 0.0051 16.2 21.8 0.0074 15.7 21.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC88419.1 - 0.0098 15.7 20.4 0.019 14.7 20.4 1.5 1 1 0 1 1 1 1 Olfactory receptor Kelch_1 PF01344.25 EMC88420.1 - 2.1e-35 120.0 5.5 6.1e-12 44.9 0.1 6.9 6 1 0 6 6 6 5 Kelch motif BACK PF07707.15 EMC88420.1 - 8.7e-32 109.3 0.3 1.9e-31 108.2 0.3 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_6 PF13964.6 EMC88420.1 - 2.6e-28 97.3 0.1 1.2e-05 25.4 0.0 6.1 3 2 3 6 6 6 5 Kelch motif BTB PF00651.31 EMC88420.1 - 1.1e-27 96.5 5.4 4.2e-27 94.6 2.4 2.4 1 1 1 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 EMC88420.1 - 1.8e-26 91.1 0.8 1.5e-05 24.7 0.1 5.6 5 0 0 5 5 5 5 Kelch motif Kelch_4 PF13418.6 EMC88420.1 - 4.2e-15 55.5 0.2 0.016 15.2 0.0 6.4 5 2 1 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.6 EMC88420.1 - 2.1e-13 50.2 1.1 0.022 15.0 0.0 6.3 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC88420.1 - 9.1e-11 41.5 1.6 0.00055 19.8 0.1 5.6 6 0 0 6 6 6 2 Kelch motif DUF3342 PF11822.8 EMC88420.1 - 0.00014 22.0 2.9 0.0018 18.5 0.6 2.8 2 1 0 2 2 2 1 Domain of unknown function (DUF3342) Kelch_1 PF01344.25 EMC88421.1 - 8.1e-36 121.4 18.1 7.6e-14 51.0 0.1 6.2 6 1 0 6 6 6 5 Kelch motif BACK PF07707.15 EMC88421.1 - 2.4e-32 111.1 0.7 2.4e-32 111.1 0.7 1.6 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 EMC88421.1 - 7.4e-29 100.2 1.5 1.6e-28 99.1 0.8 2.0 2 0 0 2 2 2 1 BTB/POZ domain Kelch_6 PF13964.6 EMC88421.1 - 3.6e-24 84.2 8.0 1.7e-05 24.9 0.0 5.6 2 1 3 5 5 5 5 Kelch motif Kelch_3 PF13415.6 EMC88421.1 - 7.5e-21 73.9 2.1 4.9e-05 23.5 0.1 5.5 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_4 PF13418.6 EMC88421.1 - 3.2e-18 65.5 1.5 0.0003 20.7 0.0 5.9 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_2 PF07646.15 EMC88421.1 - 6.2e-18 64.0 6.0 1.3e-05 25.0 0.1 5.1 5 0 0 5 5 5 4 Kelch motif Kelch_5 PF13854.6 EMC88421.1 - 4.9e-07 29.6 8.9 0.09 12.8 0.1 5.1 6 0 0 6 6 6 2 Kelch motif DUF3342 PF11822.8 EMC88421.1 - 0.011 15.9 0.6 0.032 14.4 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) PMP22_Claudin PF00822.20 EMC88423.1 - 1.4e-34 119.4 12.4 2e-34 118.9 12.4 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC88423.1 - 6.7e-10 39.0 12.4 9.9e-09 35.2 12.4 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Clc-like PF07062.12 EMC88423.1 - 8e-05 22.2 6.8 0.01 15.3 0.3 2.2 1 1 0 2 2 2 2 Clc-like ThrE PF06738.12 EMC88423.1 - 0.032 13.6 10.1 0.25 10.7 4.6 2.5 1 1 1 2 2 2 0 Putative threonine/serine exporter Amastin PF07344.11 EMC88423.1 - 4.8 7.0 13.1 0.17 11.7 4.7 2.2 1 1 1 2 2 2 0 Amastin surface glycoprotein Hydrophob_seed PF14547.6 EMC88424.1 - 0.014 15.6 6.0 0.014 15.6 6.0 2.0 1 1 1 2 2 2 0 Hydrophobic seed protein TPT PF03151.16 EMC88424.1 - 3 7.1 5.1 6.5 6.0 0.9 2.0 1 1 1 2 2 2 0 Triose-phosphate Transporter family Oberon_cc PF16312.5 EMC88425.1 - 9.3 6.2 11.9 14 5.7 0.7 3.6 3 0 0 3 3 3 0 Coiled-coil region of Oberon Sulfotransfer_1 PF00685.27 EMC88426.1 - 2.7e-31 109.0 0.0 3.1e-31 108.8 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC88426.1 - 6.6e-12 46.3 0.0 8.7e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_2 PF03567.14 EMC88426.1 - 0.015 15.2 0.0 0.043 13.7 0.0 1.7 2 0 0 2 2 2 0 Sulfotransferase family REPA_OB_2 PF16900.5 EMC88427.1 - 2.4e-07 30.6 0.0 0.00014 21.7 0.0 2.4 2 0 0 2 2 2 2 Replication protein A OB domain CDC24_OB3 PF17244.2 EMC88427.1 - 1.2e-05 25.2 0.5 0.00037 20.3 0.7 2.2 2 0 0 2 2 2 2 Cell division control protein 24, OB domain 3 FAA_hydrolase PF01557.18 EMC88428.1 - 2.8e-56 190.6 0.0 3.4e-56 190.4 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family HAGH_C PF16123.5 EMC88429.1 - 2.5e-23 82.4 0.1 5.5e-23 81.3 0.1 1.6 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 EMC88429.1 - 1.7e-11 44.5 0.9 8.3e-07 29.2 0.5 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EMC88429.1 - 0.00069 19.2 0.2 0.0013 18.3 0.2 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain HAGH_C PF16123.5 EMC88430.1 - 3e-25 88.5 0.4 5.3e-25 87.7 0.4 1.4 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 EMC88430.1 - 2.1e-09 37.7 2.1 1.1e-08 35.3 2.1 1.9 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EMC88430.1 - 6.5e-05 22.5 0.3 0.00013 21.6 0.3 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Fe_hyd_lg_C PF02906.14 EMC88431.1 - 4.1e-75 252.6 0.0 6.1e-75 252.0 0.0 1.2 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Fe_hyd_SSU PF02256.17 EMC88431.1 - 5.2e-10 39.2 0.0 1e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 Iron hydrogenase small subunit COR PF16095.5 EMC88431.1 - 0.06 13.1 0.1 1.2 8.9 0.0 2.3 1 1 1 2 2 2 0 C-terminal of Roc, COR, domain Mesothelin PF06060.12 EMC88433.1 - 1.1e-132 443.5 0.3 1.3e-132 443.2 0.3 1.0 1 0 0 1 1 1 1 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) Mesothelin PF06060.12 EMC88435.1 - 3.8e-12 45.2 0.2 4.1e-12 45.1 0.2 1.0 1 0 0 1 1 1 1 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) PseudoU_synth_2 PF00849.22 EMC88437.1 - 7.9e-24 84.6 0.0 1.1e-23 84.1 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase AAA PF00004.29 EMC88438.1 - 5e-14 52.9 0.0 7.8e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EMC88438.1 - 2.4e-10 40.5 0.0 4.6e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EMC88438.1 - 3.7e-08 33.3 0.0 6e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 EMC88438.1 - 1.4e-07 31.6 0.1 1.1e-06 28.7 0.0 2.0 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_14 PF13173.6 EMC88438.1 - 5.5e-06 26.4 0.0 9.8e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EMC88438.1 - 1.7e-05 25.1 0.1 0.0016 18.7 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EMC88438.1 - 3.6e-05 24.2 0.0 0.0051 17.2 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 EMC88438.1 - 4.5e-05 23.3 0.0 6.9e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EMC88438.1 - 0.00012 22.3 0.0 0.00025 21.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EMC88438.1 - 0.0004 20.2 0.0 0.00075 19.3 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 EMC88438.1 - 0.00042 20.9 0.0 0.0009 19.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EMC88438.1 - 0.0022 17.5 0.1 0.009 15.5 0.0 1.9 2 1 1 3 3 3 1 P-loop containing dynein motor region NACHT PF05729.12 EMC88438.1 - 0.005 16.8 0.0 0.18 11.7 0.0 2.3 1 1 1 2 2 2 1 NACHT domain RsgA_GTPase PF03193.16 EMC88438.1 - 0.005 16.7 0.0 0.0072 16.2 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_25 PF13481.6 EMC88438.1 - 0.0069 16.0 0.0 0.019 14.5 0.0 1.7 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EMC88438.1 - 0.0072 15.6 0.0 0.01 15.1 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin TIP49 PF06068.13 EMC88438.1 - 0.0082 15.4 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain Viral_helicase1 PF01443.18 EMC88438.1 - 0.0087 15.8 0.1 0.15 11.8 0.0 2.1 1 1 1 2 2 2 1 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.15 EMC88438.1 - 0.011 15.6 0.3 0.22 11.4 0.0 2.2 1 1 1 2 2 2 0 NTPase NB-ARC PF00931.22 EMC88438.1 - 0.012 14.8 0.0 0.021 14.0 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_24 PF13479.6 EMC88438.1 - 0.012 15.3 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 EMC88438.1 - 0.012 15.4 0.0 0.025 14.4 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EMC88438.1 - 0.012 16.0 0.0 0.026 14.9 0.0 1.6 1 1 0 1 1 1 0 RNA helicase TniB PF05621.11 EMC88438.1 - 0.013 14.9 0.0 0.24 10.8 0.0 2.1 1 1 1 2 2 2 0 Bacterial TniB protein AAA_28 PF13521.6 EMC88438.1 - 0.019 15.2 0.4 0.08 13.2 0.0 2.2 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.27 EMC88438.1 - 0.02 15.4 0.0 0.053 14.0 0.0 1.6 1 1 0 1 1 1 0 ABC transporter AAA_19 PF13245.6 EMC88438.1 - 0.02 15.2 0.3 0.18 12.1 0.1 2.2 1 1 1 2 2 2 0 AAA domain AAA_17 PF13207.6 EMC88438.1 - 0.026 15.0 0.0 0.057 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 EMC88438.1 - 0.032 14.4 0.0 0.063 13.4 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain TsaE PF02367.17 EMC88438.1 - 0.035 14.1 0.0 0.064 13.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NAD_binding_1 PF00175.21 EMC88438.1 - 0.075 13.7 0.0 1.1 10.0 0.0 2.1 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain AAA_2 PF07724.14 EMC88438.1 - 0.089 12.9 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Sigma54_activat PF00158.26 EMC88438.1 - 0.13 11.9 0.0 1.4 8.6 0.0 2.1 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_8 PF12780.7 EMC88438.1 - 0.2 10.9 0.0 0.38 10.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region D4 G-gamma PF00631.22 EMC88440.1 - 9.8e-06 25.5 0.0 1e-05 25.5 0.0 1.0 1 0 0 1 1 1 1 GGL domain LMF1 PF06762.14 EMC88443.1 - 1.5e-81 274.8 11.1 1.1e-74 252.1 7.2 2.2 1 1 1 2 2 2 2 Lipase maturation factor HMG_box PF00505.19 EMC88444.1 - 5.2e-26 90.8 1.3 1.1e-25 89.8 1.3 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box Sox_N PF12444.8 EMC88444.1 - 1.3e-24 87.1 0.4 1.3e-24 87.1 0.4 3.9 3 3 0 3 3 3 1 Sox developmental protein N terminal HMG_box_2 PF09011.10 EMC88444.1 - 5.7e-11 42.9 1.5 1e-10 42.0 0.6 1.8 2 0 0 2 2 2 1 HMG-box domain 7tm_1 PF00001.21 EMC88445.1 - 1.3e-65 221.4 25.7 1.6e-65 221.1 25.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC88445.1 - 2.6e-14 53.3 22.3 3.1e-14 53.0 22.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC88445.1 - 2.4e-10 40.5 21.0 5.7e-10 39.3 21.0 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 EMC88445.1 - 5.2e-08 32.6 21.0 7.4e-08 32.1 21.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv TctB PF07331.11 EMC88445.1 - 0.0059 16.9 7.9 0.0059 16.9 7.9 2.6 2 1 1 3 3 3 1 Tripartite tricarboxylate transporter TctB family DUF1772 PF08592.11 EMC88445.1 - 1.7 9.0 5.5 1.3 9.4 2.5 2.2 1 1 2 3 3 3 0 Domain of unknown function (DUF1772) C1q PF00386.21 EMC88446.1 - 6.2e-36 123.4 1.7 7.9e-36 123.1 1.7 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 EMC88446.1 - 5.1e-08 32.5 15.7 7.9e-08 31.9 15.7 1.2 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) GbpA_2 PF18416.1 EMC88446.1 - 0.17 12.2 0.0 0.29 11.5 0.0 1.3 1 0 0 1 1 1 0 N-acetylglucosamine binding protein domain 2 Tektin PF03148.14 EMC88447.1 - 1.3e-141 471.9 33.9 1.4e-141 471.7 33.9 1.0 1 0 0 1 1 1 1 Tektin family DUF2312 PF10073.9 EMC88447.1 - 0.017 14.7 0.6 0.017 14.7 0.6 3.3 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2312) Baculo_PEP_C PF04513.12 EMC88447.1 - 0.16 12.0 6.7 0.3 11.1 0.3 3.1 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1818 PF08848.11 EMC88447.1 - 0.85 9.7 5.0 0.47 10.6 1.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1818) DUF1664 PF07889.12 EMC88447.1 - 1.9 8.5 13.0 0.37 10.8 0.3 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) DivIC PF04977.15 EMC88447.1 - 4.7 7.0 19.4 0.94 9.3 2.1 4.0 4 0 0 4 4 4 0 Septum formation initiator FlaC_arch PF05377.11 EMC88447.1 - 6.6 7.2 6.1 37 4.8 0.1 3.5 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) APG6_N PF17675.1 EMC88447.1 - 7.5 7.1 33.4 2.4 8.7 2.9 4.1 3 1 0 3 3 3 0 Apg6 coiled-coil region B9-C2 PF07162.11 EMC88448.1 - 3.6e-35 121.6 0.1 4.2e-35 121.4 0.1 1.0 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein DUF1143 PF06608.11 EMC88448.1 - 0.16 12.0 0.0 0.23 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1143) SH3_1 PF00018.28 EMC88449.1 - 1.1e-30 104.9 0.5 8.6e-17 60.5 0.1 2.5 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 EMC88449.1 - 1.7e-25 88.6 0.2 5.8e-12 45.3 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH2 PF00017.24 EMC88449.1 - 1.9e-23 82.4 0.3 3e-23 81.7 0.3 1.3 1 0 0 1 1 1 1 SH2 domain SH3_2 PF07653.17 EMC88449.1 - 5.9e-23 80.3 0.0 2.5e-10 39.9 0.0 2.6 3 0 0 3 3 3 2 Variant SH3 domain SH3_3 PF08239.11 EMC88449.1 - 0.0018 18.5 0.2 0.018 15.3 0.0 2.4 3 0 0 3 3 3 1 Bacterial SH3 domain SH2_2 PF14633.6 EMC88449.1 - 0.042 13.3 0.0 0.064 12.6 0.0 1.3 1 0 0 1 1 1 0 SH2 domain SSF PF00474.17 EMC88450.1 - 2.3e-134 448.3 25.3 7.3e-134 446.6 25.3 1.8 1 1 0 1 1 1 1 Sodium:solute symporter family SLATT_1 PF18181.1 EMC88450.1 - 0.26 11.2 4.1 3.6 7.6 0.3 2.9 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 Gemini_mov PF01708.16 EMC88450.1 - 0.75 9.6 5.2 5.8 6.8 0.0 3.2 3 0 0 3 3 3 0 Geminivirus putative movement protein Pribosyl_synth PF14572.6 EMC88451.1 - 3.5e-101 336.8 1.5 5.7e-101 336.1 1.5 1.3 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 EMC88451.1 - 1.4e-39 134.6 0.4 3.4e-39 133.4 0.4 1.7 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EMC88451.1 - 4.5e-08 32.8 0.1 3e-06 26.8 0.1 2.2 2 0 0 2 2 2 1 Phosphoribosyl transferase domain RelB PF04221.12 EMC88451.1 - 0.035 14.1 0.1 5.2 7.1 0.0 2.7 2 0 0 2 2 2 0 RelB antitoxin UN_NPL4 PF11543.8 EMC88451.1 - 0.061 13.8 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 7tm_1 PF00001.21 EMC88452.1 - 3e-44 151.3 19.3 4.5e-44 150.7 19.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TraL PF07178.11 EMC88452.1 - 0.17 12.4 0.1 0.17 12.4 0.1 2.8 3 0 0 3 3 3 0 TraL protein Synaptobrevin PF00957.21 EMC88452.1 - 1.5 8.7 4.6 11 5.8 0.1 3.0 2 1 1 3 3 3 0 Synaptobrevin SHMT PF00464.19 EMC88453.1 - 1.3e-205 682.6 0.0 1.5e-205 682.4 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase DegT_DnrJ_EryC1 PF01041.17 EMC88453.1 - 0.0027 17.1 0.0 0.0043 16.4 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Folliculin PF11704.8 EMC88454.1 - 2.3e-08 34.1 0.1 4.6e-08 33.2 0.1 1.4 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport Topoisom_bac PF01131.20 EMC88455.1 - 1e-115 387.1 0.0 2.4e-115 385.8 0.0 1.6 2 0 0 2 2 2 1 DNA topoisomerase zf-GRF PF06839.12 EMC88455.1 - 3.5e-37 126.2 19.9 3.4e-20 71.8 4.8 3.2 3 0 0 3 3 3 2 GRF zinc finger Toprim PF01751.22 EMC88455.1 - 1.8e-17 63.5 0.0 7e-17 61.5 0.0 2.0 2 0 0 2 2 2 1 Toprim domain zf-C4_Topoisom PF01396.19 EMC88455.1 - 4.7e-12 45.5 1.7 4.7e-12 45.5 1.7 3.4 4 0 0 4 4 4 1 Topoisomerase DNA binding C4 zinc finger zf-C2H2_10 PF16588.5 EMC88455.1 - 0.0069 16.1 3.7 0.02 14.6 3.7 1.7 1 0 0 1 1 1 1 C2H2 zinc-finger zf-CCHC_2 PF13696.6 EMC88455.1 - 0.058 13.2 2.8 0.2 11.5 2.8 2.0 1 0 0 1 1 1 0 Zinc knuckle Mab-21 PF03281.14 EMC88456.1 - 4.8e-17 62.2 0.0 1.3e-16 60.8 0.0 1.7 1 1 0 1 1 1 1 Mab-21 protein Gelsolin PF00626.22 EMC88457.1 - 5.4e-64 212.1 2.3 2.7e-15 56.0 0.0 6.9 6 0 0 6 6 6 6 Gelsolin repeat LRR_8 PF13855.6 EMC88457.1 - 4.4e-38 128.8 39.6 5.5e-09 35.7 8.3 6.5 5 1 1 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 EMC88457.1 - 1.2e-20 73.2 56.5 2.8e-06 27.5 5.1 8.3 2 1 8 11 11 11 11 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC88457.1 - 1.6e-05 24.5 16.5 0.0099 15.4 2.3 3.9 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 EMC88457.1 - 0.0014 18.9 46.0 0.94 10.3 0.3 11.8 12 1 0 12 12 12 3 Leucine Rich Repeat LRR_5 PF13306.6 EMC88457.1 - 0.22 11.5 2.0 10 6.1 0.2 3.0 2 1 1 3 3 3 0 BspA type Leucine rich repeat region (6 copies) 2OG-FeII_Oxy_2 PF13532.6 EMC88458.1 - 8.1e-09 35.9 0.0 1.3e-08 35.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ApoO PF09769.9 EMC88458.1 - 0.071 13.1 0.2 0.12 12.3 0.2 1.3 1 0 0 1 1 1 0 Apolipoprotein O MMR_HSR1_Xtn PF16897.5 EMC88459.1 - 5.8e-43 145.2 0.0 1.1e-42 144.3 0.0 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 EMC88459.1 - 4.9e-24 84.1 0.0 8.9e-24 83.3 0.0 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 EMC88459.1 - 9.4e-20 70.8 0.0 1.7e-19 70.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EMC88459.1 - 6.2e-10 38.8 0.0 1e-09 38.1 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EMC88459.1 - 0.023 14.8 0.3 1.5 8.8 0.0 2.3 1 1 1 2 2 2 0 Dynamin family Vac_ImportDeg PF09783.9 EMC88460.1 - 7.9e-55 185.1 5.0 8.9e-55 184.9 5.0 1.0 1 0 0 1 1 1 1 Vacuolar import and degradation protein ATP12 PF07542.11 EMC88461.1 - 1.2e-37 128.9 0.3 1.7e-37 128.3 0.3 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein LRR_9 PF14580.6 EMC88462.1 - 1.2e-15 57.5 2.3 1.2e-15 57.5 2.3 3.6 2 1 2 4 4 4 2 Leucine-rich repeat LRR_4 PF12799.7 EMC88462.1 - 1.8e-13 50.4 22.4 1.9e-05 24.9 1.5 4.2 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMC88462.1 - 5.3e-10 38.9 20.5 1.1e-05 25.1 4.8 3.9 3 1 1 4 4 4 3 Leucine rich repeat TIP120 PF08623.10 EMC88462.1 - 0.13 12.0 3.2 0.15 11.8 1.1 2.1 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) LRR_1 PF00560.33 EMC88462.1 - 0.18 12.5 10.7 1.1 10.0 0.0 5.3 5 1 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.6 EMC88462.1 - 2 8.7 11.1 1.6 9.0 0.3 4.2 4 0 0 4 4 4 0 Leucine Rich repeat VHS PF00790.19 EMC88463.1 - 1.1e-44 151.8 0.1 3.2e-44 150.2 0.0 1.9 2 0 0 2 2 2 1 VHS domain GAT PF03127.14 EMC88463.1 - 1.3e-27 95.9 2.4 3.3e-27 94.6 2.4 1.7 1 0 0 1 1 1 1 GAT domain ENTH PF01417.20 EMC88463.1 - 0.013 15.5 0.0 0.028 14.5 0.0 1.5 1 0 0 1 1 1 0 ENTH domain PEMT PF04191.13 EMC88465.1 - 2.2e-31 108.4 6.9 2.3e-31 108.3 5.2 1.8 2 0 0 2 2 2 1 Phospholipid methyltransferase Herpes_UL74 PF07982.12 EMC88465.1 - 0.11 11.5 0.0 0.14 11.1 0.0 1.1 1 0 0 1 1 1 0 Herpes UL74 glycoproteins Ras PF00071.22 EMC88466.1 - 1.8e-37 128.4 0.0 2.6e-37 127.9 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC88466.1 - 7.6e-13 48.7 0.0 1.2e-12 48.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC88466.1 - 2.8e-07 30.2 0.0 4.7e-07 29.4 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC88466.1 - 0.00019 21.0 0.0 0.0021 17.6 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EMC88466.1 - 0.0088 15.5 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit TniB PF05621.11 EMC88466.1 - 0.043 13.2 0.0 0.16 11.4 0.0 1.9 2 1 1 3 3 3 0 Bacterial TniB protein GAPT PF11770.8 EMC88466.1 - 0.066 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) MMR_HSR1 PF01926.23 EMC88466.1 - 0.093 12.8 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase Med9 PF07544.13 EMC88467.1 - 5.4e-20 71.3 3.6 6.2e-20 71.1 3.6 1.0 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Med21 PF11221.8 EMC88467.1 - 1.4e-08 35.1 2.2 1.7e-08 34.9 2.2 1.1 1 0 0 1 1 1 1 Subunit 21 of Mediator complex APG17 PF04108.12 EMC88467.1 - 0.0015 17.7 0.2 0.0016 17.6 0.2 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 PHA_synth_III_E PF09712.10 EMC88467.1 - 0.0019 17.3 0.3 0.002 17.3 0.3 1.1 1 0 0 1 1 1 1 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) 4HB_MCP_1 PF12729.7 EMC88467.1 - 0.016 14.8 0.1 0.019 14.5 0.1 1.1 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction HSBP1 PF06825.12 EMC88467.1 - 0.017 15.0 0.7 0.017 15.0 0.7 1.8 2 0 0 2 2 2 0 Heat shock factor binding protein 1 DASH_Duo1 PF08651.10 EMC88467.1 - 0.018 14.8 0.4 0.032 14.0 0.2 1.4 1 1 0 1 1 1 0 DASH complex subunit Duo1 OmpH PF03938.14 EMC88467.1 - 0.021 15.2 1.8 0.027 14.8 1.8 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) GrpE PF01025.19 EMC88467.1 - 0.025 14.2 0.4 0.029 14.0 0.4 1.1 1 0 0 1 1 1 0 GrpE FapA PF03961.13 EMC88467.1 - 0.025 13.2 1.7 0.029 13.0 1.7 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A ELK PF03789.13 EMC88467.1 - 0.032 14.3 1.8 0.14 12.2 0.5 2.3 2 0 0 2 2 2 0 ELK domain RPW8 PF05659.11 EMC88467.1 - 0.05 13.3 0.9 0.052 13.2 0.9 1.1 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF3452 PF11934.8 EMC88467.1 - 0.088 12.4 1.8 0.28 10.7 1.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3452) XPC-binding PF09280.11 EMC88467.1 - 0.088 12.6 7.3 5.2 6.9 3.9 2.6 2 1 1 3 3 3 0 XPC-binding domain DUF2232 PF09991.9 EMC88467.1 - 0.12 11.5 0.6 0.13 11.4 0.6 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Enkurin PF13864.6 EMC88467.1 - 0.15 12.5 5.1 0.57 10.6 0.6 2.0 1 1 1 2 2 2 0 Calmodulin-binding TBCC_N PF16752.5 EMC88467.1 - 0.45 11.0 6.6 3.5 8.1 6.6 1.9 1 1 0 1 1 1 0 Tubulin-specific chaperone C N-terminal domain NT5C PF06941.12 EMC88469.1 - 4.8e-27 95.0 0.0 5.6e-27 94.8 0.0 1.0 1 0 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) PCI PF01399.27 EMC88470.1 - 1.3e-19 70.6 1.0 5.2e-19 68.7 0.2 2.3 2 0 0 2 2 2 1 PCI domain RasGEF PF00617.19 EMC88470.1 - 0.0055 16.9 1.0 0.5 10.6 0.1 2.9 3 0 0 3 3 3 1 RasGEF domain TPR_1 PF00515.28 EMC88470.1 - 0.0079 16.0 2.5 0.017 14.9 0.9 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EMC88470.1 - 0.047 13.9 2.1 1.4 9.3 0.4 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat MAS20 PF02064.15 EMC88470.1 - 0.051 13.7 0.2 0.31 11.1 0.1 2.2 2 0 0 2 2 2 0 MAS20 protein import receptor Sel1 PF08238.12 EMC88470.1 - 0.067 13.9 1.0 0.18 12.6 1.0 1.8 1 0 0 1 1 1 0 Sel1 repeat TPR_10 PF13374.6 EMC88470.1 - 0.069 13.0 0.3 1.1 9.2 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EMC88470.1 - 0.075 13.2 2.3 0.16 12.1 0.9 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 EMC88470.1 - 0.11 12.8 0.1 2.6 8.4 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Folliculin_C PF16692.5 EMC88471.1 - 1.3e-90 303.1 0.2 2.3e-90 302.3 0.2 1.4 1 0 0 1 1 1 1 Folliculin C-terminal domain Folliculin PF11704.8 EMC88471.1 - 1.3e-51 175.2 0.0 2.2e-51 174.4 0.0 1.4 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport PH PF00169.29 EMC88473.1 - 9.7e-20 71.0 0.7 9.6e-17 61.4 0.3 2.6 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 EMC88473.1 - 0.0043 17.4 8.4 0.011 16.1 3.1 3.7 3 1 0 3 3 3 1 Pleckstrin homology domain OmpH PF03938.14 EMC88473.1 - 0.006 16.9 11.9 0.006 16.9 11.9 4.7 3 1 0 4 4 4 2 Outer membrane protein (OmpH-like) Baculo_PEP_C PF04513.12 EMC88473.1 - 7.4 6.6 14.0 1.2 9.1 7.1 2.8 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus TACI-CRD2 PF09305.10 EMC88474.1 - 5.3e-24 84.0 23.8 1.2e-20 73.2 8.1 3.7 4 0 0 4 4 4 2 TACI, cysteine-rich domain BCMA-Tall_bind PF09257.10 EMC88474.1 - 0.00017 21.6 16.3 0.0032 17.5 6.6 3.2 3 0 0 3 3 3 2 BCMA, TALL-1 binding UCH PF00443.29 EMC88475.1 - 7.1e-58 196.1 0.1 8.7e-58 195.8 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMC88475.1 - 8.1e-25 88.1 2.9 2.8e-24 86.3 2.9 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 EMC88475.1 - 2.8e-05 23.7 3.5 0.0094 15.4 0.1 3.2 3 0 0 3 3 3 2 Ubiquitin-specific peptidase-like, SUMO isopeptidase ISG65-75 PF11727.8 EMC88475.1 - 0.16 11.2 4.0 0.048 12.9 0.7 1.8 2 0 0 2 2 2 0 Invariant surface glycoprotein DUF1924 PF09086.11 EMC88475.1 - 1.5 9.2 6.2 1.1 9.7 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1924) adh_short PF00106.25 EMC88477.1 - 2.3e-52 177.3 0.4 3.2e-52 176.8 0.4 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC88477.1 - 2.3e-37 128.8 0.9 3.1e-37 128.4 0.9 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC88477.1 - 7.8e-12 45.5 0.1 1.4e-11 44.7 0.1 1.4 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EMC88477.1 - 4.2e-06 26.3 0.0 3.6e-05 23.3 0.0 2.0 1 1 1 2 2 2 1 Fungal family of unknown function (DUF1776) Polysacc_synt_2 PF02719.15 EMC88477.1 - 0.0038 16.4 0.1 0.0056 15.8 0.1 1.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_2 PF03446.15 EMC88477.1 - 0.0054 16.9 0.1 0.014 15.6 0.0 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase THF_DHG_CYH_C PF02882.19 EMC88477.1 - 0.093 12.0 0.6 4.2 6.7 0.0 2.5 3 0 0 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain HEPN PF05168.14 EMC88477.1 - 0.11 12.7 0.0 0.68 10.1 0.0 2.2 3 0 0 3 3 3 0 HEPN domain Mito_morph_reg PF14972.6 EMC88478.1 - 3.6e-78 260.7 0.6 4.1e-78 260.6 0.6 1.0 1 0 0 1 1 1 1 Mitochondrial morphogenesis regulator Pkinase PF00069.25 EMC88479.1 - 3.1e-56 190.7 0.0 3.7e-56 190.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC88479.1 - 1.5e-38 132.6 0.0 1.8e-38 132.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC88479.1 - 1.5e-05 24.5 0.0 2.5e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EMC88479.1 - 0.0017 17.3 0.0 0.0031 16.5 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 EMC88479.1 - 0.0037 16.4 0.2 0.0058 15.7 0.2 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Pkinase_fungal PF17667.1 EMC88479.1 - 0.0096 14.7 0.1 0.023 13.5 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EMC88479.1 - 0.014 15.4 0.0 0.023 14.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 EMC88479.1 - 0.022 14.4 0.0 0.035 13.7 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF4344 PF14247.6 EMC88479.1 - 0.035 13.8 0.0 0.049 13.3 0.0 1.2 1 0 0 1 1 1 0 Putative metallopeptidase DHR-2 PF06920.13 EMC88479.1 - 0.095 11.3 0.0 0.14 10.8 0.0 1.2 1 0 0 1 1 1 0 Dock homology region 2 RIO1 PF01163.22 EMC88479.1 - 0.1 12.2 0.1 0.21 11.2 0.1 1.4 1 0 0 1 1 1 0 RIO1 family IRK_C PF17655.1 EMC88480.1 - 1.2e-77 259.5 0.0 1.6e-77 259.0 0.0 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 EMC88480.1 - 9.4e-66 220.0 1.4 1.3e-65 219.5 1.4 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain IRK_N PF08466.10 EMC88480.1 - 2.5e-26 91.5 0.1 4.8e-26 90.7 0.1 1.5 1 0 0 1 1 1 1 Inward rectifier potassium channel N-terminal Ion_trans_2 PF07885.16 EMC88480.1 - 0.038 13.9 5.9 0.097 12.6 5.9 1.7 1 1 0 1 1 1 0 Ion channel G10 PF01125.17 EMC88482.1 - 3.5e-67 224.7 5.2 3.8e-67 224.6 5.2 1.0 1 0 0 1 1 1 1 G10 protein PP28 PF10252.9 EMC88483.1 - 3.1e-30 104.5 16.0 3.1e-30 104.5 16.0 2.5 2 1 0 2 2 2 1 Casein kinase substrate phosphoprotein PP28 RPN2_C PF18004.1 EMC88483.1 - 0.006 16.5 7.8 0.006 16.5 7.8 2.3 1 1 1 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain Nop53 PF07767.11 EMC88483.1 - 4.1 6.7 33.4 4.8 6.5 33.4 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) WD40 PF00400.32 EMC88484.1 - 2.9e-12 46.9 17.9 3.6e-05 24.4 0.2 6.6 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC88484.1 - 2.9e-12 46.7 0.7 0.002 18.4 0.0 4.1 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC88484.1 - 9.6e-05 22.3 0.9 0.15 11.9 0.1 3.3 2 1 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A GD_N PF16030.5 EMC88484.1 - 0.12 12.7 0.0 0.33 11.3 0.0 1.7 2 0 0 2 2 2 0 Serine protease gd N-terminus WD40 PF00400.32 EMC88485.1 - 4.6e-12 46.2 14.2 0.00015 22.5 0.5 6.2 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC88485.1 - 3.4e-09 36.9 1.3 0.065 13.5 0.0 3.8 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain LytB_WW PF18342.1 EMC88485.1 - 0.056 13.6 1.1 0.29 11.3 0.2 2.3 2 0 0 2 2 2 0 Endo-beta-N-acetylglucosaminidase LytB WW domain HECT PF00632.25 EMC88486.1 - 3.1e-102 342.2 0.0 4e-102 341.8 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 EMC88486.1 - 2.7e-17 62.5 3.1 7.4e-09 35.5 0.1 2.6 2 0 0 2 2 2 2 WW domain C2 PF00168.30 EMC88486.1 - 1.4e-14 54.2 0.0 3.4e-14 53.0 0.0 1.6 1 0 0 1 1 1 1 C2 domain HPS3_N PF14761.6 EMC88486.1 - 0.068 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 IBR PF01485.21 EMC88487.1 - 5.1e-06 26.6 42.2 0.00021 21.5 9.8 4.1 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain Actin PF00022.19 EMC88488.1 - 6.5e-152 505.9 0.0 2.1e-151 504.2 0.0 1.6 1 1 0 1 1 1 1 Actin F-box PF00646.33 EMC88490.1 - 7e-07 29.0 1.8 7e-07 29.0 1.8 2.6 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EMC88490.1 - 5.9e-06 26.1 1.0 5.9e-06 26.1 1.0 2.6 3 0 0 3 3 3 1 F-box-like LRR_4 PF12799.7 EMC88490.1 - 0.0024 18.2 14.4 0.73 10.3 0.3 6.0 5 2 1 6 6 6 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EMC88490.1 - 0.76 10.0 14.0 31 5.0 0.3 6.4 6 0 0 6 6 6 0 Leucine Rich repeat Nucleoside_tran PF01733.18 EMC88492.1 - 7e-51 173.4 2.1 7e-51 173.4 2.1 2.0 2 1 0 2 2 2 1 Nucleoside transporter MFS_1 PF07690.16 EMC88492.1 - 0.0046 15.9 24.2 0.018 14.0 9.3 2.7 2 1 0 2 2 2 2 Major Facilitator Superfamily WD40 PF00400.32 EMC88493.1 - 3.9e-05 24.3 0.0 4.1 8.4 0.0 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC88493.1 - 0.0016 18.7 0.0 0.18 12.2 0.0 3.4 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMC88493.1 - 0.068 12.1 0.2 5.8 5.8 0.0 2.3 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein VID27 PF08553.10 EMC88493.1 - 0.17 10.9 0.0 0.3 10.1 0.0 1.3 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain HlyIII PF03006.20 EMC88494.1 - 6.9e-19 68.5 19.2 8.6e-19 68.1 19.2 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF2842 PF11003.8 EMC88494.1 - 6 7.2 14.6 1 9.7 2.4 3.5 3 1 1 4 4 4 0 Protein of unknown function (DUF2842) DIL PF01843.19 EMC88495.1 - 9.2e-23 80.5 1.2 2.1e-22 79.4 1.2 1.6 1 0 0 1 1 1 1 DIL domain RA PF00788.23 EMC88495.1 - 3.6e-17 62.8 0.0 6.7e-17 61.9 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PDZ PF00595.24 EMC88495.1 - 1.7e-10 41.1 0.0 3.1e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC88495.1 - 9.7e-10 38.2 0.0 2.7e-09 36.8 0.0 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC88495.1 - 0.00062 20.0 0.0 0.0013 19.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Forkhead PF00250.18 EMC88496.1 - 2.4e-41 139.9 0.2 6.9e-41 138.4 0.2 1.8 1 0 0 1 1 1 1 Forkhead domain SPG48 PF14764.6 EMC88496.1 - 2.8e-41 140.7 3.4 2.8e-41 140.7 3.4 3.2 3 0 0 3 3 3 1 AP-5 complex subunit, vesicle trafficking p450 PF00067.22 EMC88497.1 - 6.5e-121 404.3 0.2 7.4e-121 404.1 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EMC88498.1 - 1.2e-118 396.9 0.2 1.3e-118 396.7 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 CARD PF00619.21 EMC88499.1 - 7.5e-22 77.2 0.0 2.7e-21 75.4 0.0 2.0 1 0 0 1 1 1 1 Caspase recruitment domain PDZ PF00595.24 EMC88499.1 - 6.9e-06 26.3 0.0 1.6e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Guanylate_kin PF00625.21 EMC88499.1 - 0.00061 19.5 6.8 0.00071 19.3 0.1 2.6 2 0 0 2 2 2 1 Guanylate kinase PDZ_6 PF17820.1 EMC88499.1 - 0.00069 19.4 0.0 0.002 17.9 0.0 1.8 1 0 0 1 1 1 1 PDZ domain Peptidase_M54 PF07998.11 EMC88500.1 - 8e-05 22.7 1.5 0.00089 19.3 3.3 1.8 2 0 0 2 2 2 1 Peptidase family M54 Peptidase_M10 PF00413.24 EMC88500.1 - 0.19 11.6 0.0 0.26 11.1 0.0 1.3 1 0 0 1 1 1 0 Matrixin HEAT PF02985.22 EMC88501.1 - 5.1e-09 35.6 8.9 0.0062 16.7 0.0 6.4 6 0 0 6 6 6 2 HEAT repeat HEAT_2 PF13646.6 EMC88501.1 - 2.8e-07 30.8 0.4 3.2e-05 24.3 0.0 3.9 5 0 0 5 5 5 1 HEAT repeats RTP1_C1 PF10363.9 EMC88501.1 - 0.0045 17.2 0.1 0.032 14.4 0.0 2.5 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 EMC88501.1 - 0.0077 16.7 9.5 0.073 13.6 0.1 4.9 5 1 1 6 6 6 1 HEAT-like repeat Cnd1 PF12717.7 EMC88501.1 - 0.036 14.1 0.0 0.2 11.7 0.0 2.3 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 IQ PF00612.27 EMC88502.1 - 8.9e-14 49.9 1.1 0.00012 21.5 0.0 3.8 3 0 0 3 3 3 3 IQ calmodulin-binding motif SlyX PF04102.12 EMC88502.1 - 0.019 15.6 0.2 0.019 15.6 0.2 6.6 6 1 2 8 8 8 0 SlyX SOGA PF11365.8 EMC88502.1 - 0.026 15.6 8.9 0.026 15.6 8.9 4.7 3 2 0 4 4 4 0 Protein SOGA Cnn_1N PF07989.11 EMC88502.1 - 0.061 13.5 0.4 0.061 13.5 0.4 5.7 3 2 3 6 6 6 0 Centrosomin N-terminal motif 1 FliE PF02049.18 EMC88502.1 - 0.79 9.9 6.8 4.8 7.4 0.2 3.3 2 0 0 2 2 2 0 Flagellar hook-basal body complex protein FliE Gal-bind_lectin PF00337.22 EMC88503.1 - 1.2e-30 105.8 1.0 1.7e-18 66.5 0.0 2.0 2 0 0 2 2 2 2 Galactoside-binding lectin DUF3916 PF13079.6 EMC88503.1 - 0.024 14.5 0.1 0.035 14.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3916) 7tm_1 PF00001.21 EMC88504.1 - 4.4e-44 150.8 16.6 5.6e-44 150.5 16.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC88504.1 - 9.2e-06 25.5 18.2 5e-05 23.1 18.2 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC88504.1 - 0.00028 20.7 9.1 0.00044 20.1 9.1 1.5 1 1 0 1 1 1 1 Olfactory receptor Serpentine_r_xa PF03383.15 EMC88504.1 - 0.018 15.1 3.4 0.018 15.1 3.4 3.0 1 1 2 3 3 3 0 Caenorhabditis serpentine receptor-like protein, class xa DUF4212 PF13937.6 EMC88504.1 - 0.11 12.9 4.7 3.2 8.2 0.2 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4212) Git3 PF11710.8 EMC88504.1 - 2.8 7.7 16.4 0.073 12.8 9.9 1.7 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 Sulfotransfer_2 PF03567.14 EMC88505.1 - 1.3e-63 215.2 1.8 2e-63 214.7 1.8 1.3 1 0 0 1 1 1 1 Sulfotransferase family eIF2A PF08662.11 EMC88506.1 - 6.3e-72 241.5 7.5 3e-66 223.0 2.4 4.1 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 EMC88506.1 - 6.8e-07 29.0 0.1 1.6e-06 27.8 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ANAPC4_WD40 PF12894.7 EMC88506.1 - 5.8e-06 26.5 2.0 0.42 10.9 0.0 5.9 4 2 2 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Methyltr_RsmF_N PF17125.5 EMC88506.1 - 0.059 13.9 0.6 2.4 8.7 0.0 3.5 3 1 1 4 4 4 0 N-terminal domain of 16S rRNA methyltransferase RsmF Nup35_RRM PF05172.13 EMC88506.1 - 0.09 12.7 0.0 0.25 11.3 0.0 1.7 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF4060 PF13269.6 EMC88506.1 - 0.18 11.9 0.1 0.73 10.0 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4060) PD40 PF07676.12 EMC88506.1 - 0.44 10.6 5.6 60 3.7 0.1 4.8 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 EMC88506.1 - 0.55 11.2 5.6 3.2e+02 2.4 0.0 6.1 6 1 1 7 7 7 0 WD domain, G-beta repeat PX PF00787.24 EMC88507.1 - 1.7e-21 76.3 2.0 1.7e-21 76.3 2.0 2.0 2 0 0 2 2 2 1 PX domain Perilipin PF03036.16 EMC88507.1 - 0.0019 17.3 2.7 0.012 14.6 2.4 2.0 2 0 0 2 2 2 1 Perilipin family EPSP_synthase PF00275.20 EMC88507.1 - 0.095 11.4 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) NUDIX PF00293.28 EMC88508.1 - 3.5e-15 56.2 0.1 4.5e-15 55.9 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain FtsJ PF01728.19 EMC88509.1 - 9.9e-52 175.6 0.0 1.2e-51 175.4 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase IL5 PF02025.15 EMC88509.1 - 0.06 13.6 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 Interleukin 5 MAD PF05557.13 EMC88510.1 - 1.9e-236 786.6 100.8 2.2e-236 786.4 100.8 1.0 1 0 0 1 1 1 1 Mitotic checkpoint protein TSC22 PF01166.18 EMC88510.1 - 2.1e-05 24.7 4.7 2.1e-05 24.7 4.7 10.3 8 2 2 10 10 10 2 TSC-22/dip/bun family DUF4200 PF13863.6 EMC88510.1 - 0.00061 20.2 9.6 0.00061 20.2 9.6 8.0 5 2 2 7 7 7 1 Domain of unknown function (DUF4200) Amidohydro_1 PF01979.20 EMC88510.1 - 0.08 12.2 2.8 0.17 11.2 2.8 1.5 1 0 0 1 1 1 0 Amidohydrolase family LRR_8 PF13855.6 EMC88511.1 - 3.3e-25 87.6 11.0 2.2e-12 46.5 0.3 3.4 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EMC88511.1 - 1.3e-08 35.0 11.4 0.00089 19.6 0.3 3.6 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC88511.1 - 4.4e-08 33.2 0.2 9.1e-08 32.1 0.2 1.5 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC88511.1 - 0.0048 16.4 0.6 0.037 13.5 0.6 2.1 1 1 0 1 1 1 1 Leucine-rich repeat LRR_1 PF00560.33 EMC88511.1 - 0.05 14.2 6.3 66 4.7 0.0 5.3 5 0 0 5 5 5 0 Leucine Rich Repeat MSC PF09402.10 EMC88511.1 - 0.077 12.4 0.0 0.26 10.7 0.0 1.7 2 0 0 2 2 2 0 Man1-Src1p-C-terminal domain FixQ PF05545.11 EMC88511.1 - 0.09 12.8 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ DUF5512 PF17631.2 EMC88511.1 - 0.12 12.4 0.2 6.9 6.7 0.0 2.8 2 1 0 2 2 2 0 Family of unknown function (DUF5512) Caskin1-CID PF16600.5 EMC88511.1 - 1.4 9.5 4.2 3.3 8.4 4.2 1.5 1 0 0 1 1 1 0 Caskin1 CASK-interaction domain LRR_6 PF13516.6 EMC88511.1 - 2.4 8.4 7.9 14 6.0 0.1 4.2 4 0 0 4 4 4 0 Leucine Rich repeat PAC3 PF10178.9 EMC88512.1 - 1.8e-28 98.5 0.0 2.3e-28 98.1 0.0 1.2 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 Solute_trans_a PF03619.16 EMC88513.1 - 1.7e-93 313.0 22.5 2.2e-93 312.7 22.5 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha DUF1642 PF07852.11 EMC88513.1 - 0.12 13.0 0.0 0.29 11.7 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1642) bZIP_Maf PF03131.17 EMC88514.1 - 1.6e-34 118.3 12.5 1.9e-34 118.0 12.5 1.1 1 0 0 1 1 1 1 bZIP Maf transcription factor DivIC PF04977.15 EMC88514.1 - 0.00011 21.9 5.0 0.00011 21.9 5.0 2.1 1 1 1 2 2 2 1 Septum formation initiator bZIP_1 PF00170.21 EMC88514.1 - 0.0002 21.4 16.6 0.0046 17.0 16.6 2.4 1 1 0 1 1 1 1 bZIP transcription factor Cnn_1N PF07989.11 EMC88514.1 - 0.003 17.7 7.8 0.0074 16.4 7.7 1.8 1 1 0 1 1 1 1 Centrosomin N-terminal motif 1 DUF1192 PF06698.11 EMC88514.1 - 0.0054 16.8 6.2 0.043 13.9 0.1 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1192) Prominin PF05478.11 EMC88514.1 - 0.013 13.5 1.2 0.016 13.2 1.2 1.0 1 0 0 1 1 1 0 Prominin Spc24 PF08286.11 EMC88514.1 - 0.033 14.4 1.4 0.06 13.6 0.2 1.9 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 bZIP_2 PF07716.15 EMC88514.1 - 0.035 14.2 11.5 0.035 14.2 11.5 2.5 1 1 2 3 3 3 0 Basic region leucine zipper FapA PF03961.13 EMC88514.1 - 0.087 11.4 2.5 0.092 11.3 2.5 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DASH_Spc19 PF08287.11 EMC88514.1 - 0.25 11.2 10.1 0.35 10.7 10.1 1.2 1 0 0 1 1 1 0 Spc19 DUF4164 PF13747.6 EMC88514.1 - 0.28 11.5 8.3 0.66 10.3 8.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) GIT_CC PF16559.5 EMC88514.1 - 0.3 11.0 4.6 0.16 11.8 1.7 2.1 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Mst1_SARAH PF11629.8 EMC88514.1 - 0.34 11.0 6.3 7.6 6.7 2.0 2.6 2 1 0 2 2 2 0 C terminal SARAH domain of Mst1 YabA PF06156.13 EMC88514.1 - 0.36 11.5 6.9 0.16 12.7 2.5 2.0 1 1 1 2 2 2 0 Initiation control protein YabA Nup54 PF13874.6 EMC88514.1 - 1.1 9.3 8.6 1.9 8.6 8.6 1.3 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Spc7 PF08317.11 EMC88514.1 - 1.4 7.7 9.5 2.3 7.0 9.5 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein ZapB PF06005.12 EMC88514.1 - 2.2 8.8 13.5 4.2 7.9 7.8 2.4 1 1 1 2 2 2 0 Cell division protein ZapB DUF2205 PF10224.9 EMC88514.1 - 2.8 8.0 8.2 0.83 9.7 3.1 2.2 1 1 1 2 2 2 0 Short coiled-coil protein XkdW PF09636.10 EMC88514.1 - 8.5 6.5 6.4 6.2 7.0 2.4 2.1 1 1 1 2 2 2 0 XkdW protein APG6_N PF17675.1 EMC88514.1 - 8.9 6.8 12.9 27 5.3 12.9 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region Glyco_hydro_31 PF01055.26 EMC88515.1 - 2.2e-160 534.6 0.0 3e-160 534.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 EMC88515.1 - 1.6e-31 108.9 0.1 5e-31 107.3 0.0 1.9 2 0 0 2 2 2 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Trefoil PF00088.18 EMC88515.1 - 3.3e-14 52.5 5.0 3.3e-14 52.5 5.0 1.9 2 0 0 2 2 2 1 Trefoil (P-type) domain Gal_mutarotas_2 PF13802.6 EMC88515.1 - 8.2e-11 42.1 0.4 4.5e-10 39.7 0.1 2.4 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 EMC88515.1 - 0.0017 18.6 0.1 0.0034 17.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) DUF3585 PF12130.8 EMC88516.1 - 3.8e-41 140.4 24.9 5.8e-41 139.8 24.9 1.3 1 0 0 1 1 1 1 Bivalent Mical/EHBP Rab binding domain LIM PF00412.22 EMC88516.1 - 7.5e-06 26.1 2.0 1.9e-05 24.8 2.0 1.7 1 0 0 1 1 1 1 LIM domain CH PF00307.31 EMC88516.1 - 0.00017 21.7 0.0 0.00036 20.7 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain Pox_A_type_inc PF04508.12 EMC88516.1 - 1.2 9.1 4.8 4.7 7.2 1.2 2.8 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Homeodomain PF00046.29 EMC88517.1 - 4.8e-20 71.2 3.5 6.2e-20 70.8 3.5 1.1 1 0 0 1 1 1 1 Homeodomain 7tm_1 PF00001.21 EMC88518.1 - 3.4e-41 141.3 16.9 4.4e-41 140.9 16.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC88518.1 - 3.3e-05 23.4 16.0 4.4e-05 23.0 16.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Abhydrolase_9_N PF15420.6 EMC88518.1 - 0.32 11.0 3.0 0.53 10.3 3.0 1.3 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus PHO4 PF01384.20 EMC88518.1 - 1.8 7.5 6.1 0.78 8.7 4.0 1.5 1 1 1 2 2 2 0 Phosphate transporter family 7tm_1 PF00001.21 EMC88520.1 - 4e-13 49.3 17.2 5.9e-13 48.7 17.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Sid-5 PF17204.3 EMC88520.1 - 0.49 10.6 0.1 0.49 10.6 0.1 2.6 3 1 0 3 3 3 0 Sid-5 family Col_cuticle_N PF01484.17 EMC88520.1 - 1.1 9.4 0.1 1.1 9.4 0.1 3.2 2 0 0 2 2 2 0 Nematode cuticle collagen N-terminal domain DUF2373 PF10180.9 EMC88521.1 - 2.6e-24 84.8 1.5 2.6e-24 84.8 1.5 1.7 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2373) YL1 PF05764.13 EMC88521.1 - 0.004 17.3 6.9 0.0047 17.1 6.9 1.0 1 0 0 1 1 1 1 YL1 nuclear protein p450 PF00067.22 EMC88522.1 - 6.7e-134 447.1 0.1 7.5e-134 446.9 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 DNA_pol3_a_NII PF11490.8 EMC88522.1 - 0.12 12.3 0.2 3.5 7.6 0.1 2.4 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II ArfGap PF01412.18 EMC88524.1 - 5.5e-28 97.4 0.0 9.2e-28 96.7 0.0 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 EMC88524.1 - 4.2e-22 78.6 0.3 2.6e-12 47.2 0.1 2.3 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 EMC88524.1 - 1.7e-08 34.8 1.7 3.9e-05 24.0 0.3 3.4 2 2 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 EMC88524.1 - 8.6e-05 22.7 3.9 0.08 13.2 0.1 2.9 3 1 0 3 3 3 2 Pleckstrin homology domain PH_3 PF14593.6 EMC88524.1 - 0.0012 18.9 0.2 0.19 11.8 0.0 2.8 3 0 0 3 3 3 1 PH domain DUF410 PF04190.13 EMC88525.1 - 3e-77 259.9 0.1 3.4e-77 259.7 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF410) TPR_2 PF07719.17 EMC88525.1 - 0.024 14.7 0.1 4.7 7.6 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat SDH_C PF18317.1 EMC88525.1 - 0.3 10.9 1.0 1.3 8.8 0.9 2.2 2 0 0 2 2 2 0 Shikimate 5'-dehydrogenase C-terminal domain Sad1_UNC PF07738.13 EMC88526.1 - 1.5e-43 148.0 0.0 3e-43 147.0 0.0 1.5 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Sun2_CC2 PF18580.1 EMC88526.1 - 2.5e-15 56.4 0.8 6.6e-15 55.1 0.8 1.8 1 0 0 1 1 1 1 SUN2 coiled coil domain 2 MRP PF09387.10 EMC88526.1 - 0.00099 19.1 0.1 0.0021 18.1 0.1 1.5 1 0 0 1 1 1 1 Mitochondrial RNA binding protein MRP DUF1818 PF08848.11 EMC88526.1 - 0.098 12.8 1.3 2.8 8.0 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1818) Fez1 PF06818.15 EMC88526.1 - 0.31 11.5 3.8 0.59 10.5 1.3 2.1 2 0 0 2 2 2 0 Fez1 MRP PF09387.10 EMC88527.1 - 5e-28 98.4 1.9 7.2e-28 97.9 1.9 1.2 1 0 0 1 1 1 1 Mitochondrial RNA binding protein MRP Plasmodium_Vir PF05795.11 EMC88527.1 - 0.076 12.4 0.4 0.18 11.2 0.4 1.5 1 1 0 1 1 1 0 Plasmodium vivax Vir protein HEAT_2 PF13646.6 EMC88528.1 - 1.1e-11 45.0 0.1 0.011 16.0 0.0 5.8 3 2 3 6 6 6 4 HEAT repeats Vac14_Fab1_bd PF12755.7 EMC88528.1 - 2.3e-08 34.5 0.5 0.12 12.9 0.0 4.7 4 1 1 5 5 4 2 Vacuolar 14 Fab1-binding region HEAT PF02985.22 EMC88528.1 - 8e-07 28.8 20.6 1.3 9.5 0.0 8.5 9 0 0 9 9 8 2 HEAT repeat HEAT_EZ PF13513.6 EMC88528.1 - 3.4e-06 27.4 1.9 1.1 9.9 0.2 6.2 7 0 0 7 7 6 1 HEAT-like repeat IFRD PF05004.13 EMC88528.1 - 4.2e-06 26.1 0.3 4.2e-06 26.1 0.3 3.4 3 1 1 4 4 4 1 Interferon-related developmental regulator (IFRD) VHS PF00790.19 EMC88528.1 - 0.0044 16.9 0.3 0.14 12.0 0.0 2.9 3 0 0 3 3 3 1 VHS domain MIF4G PF02854.19 EMC88528.1 - 0.0045 16.7 1.8 0.0084 15.8 0.1 2.2 2 0 0 2 2 2 1 MIF4G domain Ecm29 PF13001.7 EMC88528.1 - 0.0065 15.2 1.3 0.055 12.2 0.1 2.9 3 1 0 3 3 3 1 Proteasome stabiliser MMS19_C PF12460.8 EMC88528.1 - 0.0074 15.5 0.3 0.0074 15.5 0.3 3.5 3 1 1 4 4 4 1 RNAPII transcription regulator C-terminal RTP1_C1 PF10363.9 EMC88528.1 - 0.088 13.0 3.4 10 6.3 0.0 4.4 4 2 1 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 MMS19_N PF14500.6 EMC88528.1 - 0.18 11.4 8.1 8.6 5.8 0.1 4.5 2 1 2 4 4 4 0 Dos2-interacting transcription regulator of RNA-Pol-II UME PF08064.13 EMC88528.1 - 4 7.4 7.4 2.2 8.2 1.9 3.4 4 1 0 4 4 4 0 UME (NUC010) domain cNMP_binding PF00027.29 EMC88529.1 - 1.6e-42 143.5 0.1 1.8e-20 72.8 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.17 EMC88529.1 - 7.5e-14 51.1 0.1 1.5e-13 50.2 0.1 1.5 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit DUF5582 PF17819.1 EMC88529.1 - 0.017 15.6 0.0 0.033 14.6 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5582) DUF5586 PF17824.1 EMC88529.1 - 0.15 11.2 1.0 0.26 10.3 0.7 1.5 1 1 1 2 2 2 0 Family of unknown function (DUF5586) Sox_N PF12444.8 EMC88531.1 - 0.055 14.6 1.0 1e+02 4.1 0.0 5.1 4 1 3 7 7 7 0 Sox developmental protein N terminal DC_STAMP PF07782.13 EMC88531.1 - 9.9 5.9 10.3 3 7.6 2.2 2.6 2 1 0 2 2 2 0 DC-STAMP-like protein Suppressor_APC PF11414.8 EMC88532.1 - 2.4e-32 110.8 6.7 1.1e-30 105.5 3.2 2.4 2 0 0 2 2 2 2 Adenomatous polyposis coli tumour suppressor protein UPF0242 PF06785.11 EMC88532.1 - 0.0094 16.1 0.8 0.0094 16.1 0.8 1.9 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus APC_N_CC PF16689.5 EMC88532.1 - 0.019 15.0 2.0 0.043 13.9 1.2 2.0 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain BRE1 PF08647.11 EMC88532.1 - 0.037 14.1 3.5 0.037 14.1 3.5 2.1 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase POX PF07526.11 EMC88532.1 - 0.054 14.1 0.4 0.39 11.3 0.0 2.0 2 0 0 2 2 2 0 Associated with HOX DUF5320 PF17253.2 EMC88532.1 - 0.062 14.4 4.7 3.3 8.9 0.1 2.8 2 1 1 3 3 3 0 Family of unknown function (DUF5320) TMF_TATA_bd PF12325.8 EMC88532.1 - 0.27 11.5 7.0 0.52 10.5 1.8 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DivIC PF04977.15 EMC88532.1 - 0.89 9.4 5.8 0.15 11.9 1.8 1.8 2 0 0 2 2 2 0 Septum formation initiator CENP-F_leu_zip PF10473.9 EMC88532.1 - 3.3 7.8 13.8 0.64 10.0 3.5 2.4 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 EMC88532.1 - 3.3 7.0 12.2 3.3 7.0 0.9 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 EMC88532.1 - 3.7 8.1 13.7 4.4 7.8 4.7 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region Glyco_hydro_47 PF01532.20 EMC88533.1 - 2.6e-154 514.5 0.0 2.3e-153 511.4 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 PBECR2 PF18810.1 EMC88534.1 - 0.056 13.7 0.0 0.061 13.6 0.0 1.1 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease2 CBM_5_12_2 PF14600.6 EMC88534.1 - 0.13 12.2 0.2 0.21 11.6 0.2 1.2 1 0 0 1 1 1 0 Cellulose-binding domain Peptidase_S28 PF05577.12 EMC88535.1 - 2.9e-77 260.3 0.0 3.3e-77 260.1 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Hydrolase_4 PF12146.8 EMC88535.1 - 9.8e-06 25.0 0.0 1.5e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EMC88535.1 - 2.5e-05 25.0 1.4 0.002 18.7 0.6 2.6 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EMC88535.1 - 0.00077 19.2 0.3 0.0021 17.8 0.0 1.9 2 1 0 2 2 2 1 alpha/beta hydrolase fold DUF2920 PF11144.8 EMC88535.1 - 0.0042 16.3 0.0 0.007 15.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2920) Peptidase_S37 PF05576.11 EMC88535.1 - 0.0091 14.7 0.0 0.017 13.8 0.0 1.4 1 0 0 1 1 1 1 PS-10 peptidase S37 Peptidase_S9 PF00326.21 EMC88535.1 - 0.025 14.1 0.1 0.044 13.2 0.1 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 EMC88535.1 - 0.15 11.8 0.0 0.34 10.7 0.0 1.5 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Kelch_1 PF01344.25 EMC88536.1 - 1.3e-34 117.5 2.2 3.4e-07 29.7 0.0 6.3 6 1 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 EMC88536.1 - 9.7e-31 105.0 2.5 4.3e-07 30.0 0.0 5.8 6 0 0 6 6 6 5 Kelch motif BTB PF00651.31 EMC88536.1 - 2.2e-22 79.3 0.0 5e-22 78.2 0.0 1.6 2 0 0 2 2 2 1 BTB/POZ domain Kelch_4 PF13418.6 EMC88536.1 - 3.2e-21 75.1 4.8 0.00015 21.7 0.1 6.5 4 2 2 6 6 6 5 Galactose oxidase, central domain BACK PF07707.15 EMC88536.1 - 1.8e-16 60.1 0.0 3.4e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_5 PF13854.6 EMC88536.1 - 4.8e-14 52.0 0.3 0.0032 17.4 0.0 6.4 6 0 0 6 6 6 2 Kelch motif Kelch_3 PF13415.6 EMC88536.1 - 3.2e-13 49.6 5.2 2.2e-05 24.6 0.0 5.4 6 1 0 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EMC88536.1 - 2.9e-08 33.4 2.7 0.25 11.4 0.0 6.4 6 1 0 6 6 6 2 Kelch motif Pkinase_Tyr PF07714.17 EMC88537.1 - 5.4e-49 166.8 0.0 7.2e-49 166.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC88537.1 - 9.2e-49 166.2 0.0 1.7e-48 165.3 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EMC88537.1 - 0.00046 19.6 0.0 0.0012 18.2 0.0 1.8 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMC88537.1 - 0.001 18.0 0.0 0.0031 16.4 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase HSCB_C PF07743.13 EMC88537.1 - 0.53 10.8 2.5 0.67 10.5 0.1 2.3 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain Fibrinogen_C PF00147.18 EMC88538.1 - 1.5e-73 247.3 11.1 1.7e-73 247.1 11.1 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Collagen PF01391.18 EMC88538.1 - 3.5e-07 29.9 12.3 7.4e-07 28.8 12.3 1.4 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) COLFI PF01410.18 EMC88538.1 - 0.028 13.7 1.1 0.031 13.6 0.1 1.5 2 0 0 2 2 2 0 Fibrillar collagen C-terminal domain MORN PF02493.20 EMC88539.1 - 3.9e-09 35.9 12.7 3e-05 23.6 1.8 3.5 3 0 0 3 3 3 3 MORN repeat TLV_coat PF00429.19 EMC88540.1 - 3.9e-06 25.8 0.7 4.7e-06 25.6 0.7 1.0 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) Pkinase PF00069.25 EMC88543.1 - 6e-25 88.1 0.0 6.9e-25 87.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC88543.1 - 2.4e-09 36.9 0.0 2.5e-09 36.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC88543.1 - 0.2 10.9 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Kinase-like ubiquitin PF00240.23 EMC88545.1 - 3.8e-09 36.1 0.0 6e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EMC88545.1 - 0.0027 17.5 0.0 0.0044 16.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EMC88545.1 - 0.011 16.1 0.0 0.021 15.1 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain Ubiquitin_2 PF14560.6 EMC88545.1 - 0.081 13.4 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain Actin PF00022.19 EMC88546.1 - 6.1e-151 502.6 0.0 2e-150 501.0 0.0 1.6 1 1 0 1 1 1 1 Actin ARID PF01388.21 EMC88547.1 - 6e-20 71.7 0.1 1.2e-19 70.8 0.1 1.5 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain DUF1451 PF07295.11 EMC88547.1 - 0.019 15.0 0.4 0.029 14.4 0.4 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain LRAT PF04970.13 EMC88548.1 - 0.0058 16.9 0.0 0.007 16.7 0.0 1.2 1 0 0 1 1 1 1 Lecithin retinol acyltransferase NLPC_P60 PF00877.19 EMC88548.1 - 0.01 15.9 0.0 0.011 15.7 0.0 1.2 1 0 0 1 1 1 0 NlpC/P60 family Amidase_5 PF05382.13 EMC88548.1 - 0.043 13.7 0.0 0.05 13.5 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage peptidoglycan hydrolase DUF5525 PF17663.1 EMC88550.1 - 6.1e-61 206.7 4.4 1.1e-52 179.4 1.0 2.0 2 0 0 2 2 2 2 Family of unknown function (DUF5525) TLV_coat PF00429.19 EMC88551.1 - 0.016 13.9 0.3 0.018 13.8 0.3 1.0 1 0 0 1 1 1 0 ENV polyprotein (coat polyprotein) Flavoprotein PF02441.19 EMC88552.1 - 1.8e-51 174.1 0.0 2.1e-51 173.8 0.0 1.0 1 0 0 1 1 1 1 Flavoprotein SCAMP PF04144.13 EMC88553.1 - 1.9e-69 233.4 17.6 2.3e-69 233.2 17.6 1.0 1 0 0 1 1 1 1 SCAMP family ODV-E18 PF10717.9 EMC88553.1 - 0.049 13.5 0.4 0.1 12.5 0.0 1.7 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 Comm PF15957.5 EMC88553.1 - 0.55 10.6 0.0 0.55 10.6 0.0 1.9 2 0 0 2 2 2 0 Commissureless Alba PF01918.21 EMC88554.1 - 2.5e-19 68.8 1.2 3.3e-19 68.5 1.2 1.2 1 0 0 1 1 1 1 Alba COX5A PF02284.16 EMC88555.1 - 5.2e-47 158.1 0.0 5.8e-47 157.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va FAM219A PF15260.6 EMC88556.1 - 6.4e-50 168.7 0.8 1.1e-49 168.0 0.8 1.3 1 1 0 1 1 1 1 Protein family FAM219A PMI_typeI PF01238.21 EMC88557.1 - 1.8e-120 402.6 0.0 8.3e-62 209.5 0.0 2.0 2 0 0 2 2 2 2 Phosphomannose isomerase type I Pkinase PF00069.25 EMC88558.1 - 1.4e-65 221.3 0.0 2.4e-65 220.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC88558.1 - 6.4e-39 133.8 0.0 8.6e-39 133.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase MIT PF04212.18 EMC88558.1 - 2.5e-33 113.9 14.0 1e-20 73.5 1.5 2.9 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain Kdo PF06293.14 EMC88558.1 - 4.7e-05 22.8 0.0 9.6e-05 21.8 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EMC88558.1 - 0.0097 15.5 0.0 0.019 14.6 0.0 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EMC88558.1 - 0.027 14.4 0.1 0.027 14.4 0.1 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family COP23 PF14218.6 EMC88559.1 - 0.013 15.3 0.0 0.089 12.6 0.1 1.9 2 0 0 2 2 2 0 Circadian oscillating protein COP23 Synaphin PF05835.12 EMC88560.1 - 6.2e-48 162.7 11.4 7.5e-48 162.4 11.4 1.1 1 0 0 1 1 1 1 Synaphin protein Pkinase_Tyr PF07714.17 EMC88561.1 - 1.5e-48 165.3 0.0 1.3e-28 100.0 0.0 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 EMC88561.1 - 6.9e-19 68.2 0.0 3.1e-10 39.9 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain p450 PF00067.22 EMC88562.1 - 1.4e-108 363.6 0.1 1.8e-108 363.3 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EMC88563.1 - 2e-109 366.4 0.0 2.5e-109 366.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Edc3_linker PF16598.5 EMC88564.1 - 7.7e-45 151.5 5.0 1.4e-44 150.6 5.0 1.5 1 0 0 1 1 1 1 Linker region of enhancer of mRNA-decapping protein 3 YjeF_N PF03853.15 EMC88564.1 - 7.9e-20 71.4 0.0 1.2e-19 70.9 0.0 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.10 EMC88564.1 - 9e-16 58.7 0.0 1.8e-15 57.7 0.0 1.5 1 0 0 1 1 1 1 FDF domain LSM14 PF12701.7 EMC88564.1 - 6.1e-10 39.1 0.0 1.6e-09 37.7 0.0 1.8 1 0 0 1 1 1 1 Scd6-like Sm domain DUF5096 PF17019.5 EMC88564.1 - 0.011 15.5 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5096) Pkinase PF00069.25 EMC88565.1 - 7.2e-46 156.7 0.1 9.1e-46 156.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC88565.1 - 1.9e-22 79.8 0.2 5.8e-21 74.9 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 EMC88566.1 - 7.4e-75 251.7 0.1 9.6e-75 251.3 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC88566.1 - 3.2e-36 125.0 0.0 4.2e-36 124.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EMC88566.1 - 1.8e-05 24.4 0.2 3.1e-05 23.7 0.2 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 EMC88566.1 - 0.00014 21.3 1.2 0.0002 20.8 0.2 1.7 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EMC88566.1 - 0.016 14.8 0.1 4.5 6.8 0.0 2.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Glycos_trans_3N PF02885.17 EMC88566.1 - 0.1 12.5 0.5 0.47 10.3 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferase family, helical bundle domain HU-CCDC81_bac_2 PF18175.1 EMC88566.1 - 0.18 11.7 0.9 4.5 7.2 0.0 2.8 3 0 0 3 3 3 0 CCDC81-like prokaryotic HU domain 2 EF-hand_7 PF13499.6 EMC88567.1 - 3.2e-13 49.9 3.7 6.5e-10 39.3 0.7 2.3 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EMC88567.1 - 7.5e-09 34.8 5.6 0.0069 16.2 0.5 3.7 3 1 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 EMC88567.1 - 2.2e-08 33.0 10.1 0.00011 21.5 0.5 3.6 3 1 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EMC88567.1 - 4.8e-05 23.1 7.9 0.01 15.6 2.1 2.9 2 1 0 2 2 2 2 EF-hand domain pair PMBR PF09373.10 EMC88567.1 - 0.02 15.0 0.0 7.7 6.9 0.0 3.4 4 0 0 4 4 4 0 Pseudomurein-binding repeat EF-hand_5 PF13202.6 EMC88567.1 - 0.049 13.1 0.8 0.049 13.1 0.8 3.9 4 1 1 5 5 5 0 EF hand Iso_dh PF00180.20 EMC88568.1 - 2.4e-112 375.5 0.0 2.8e-112 375.3 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase AMP-binding PF00501.28 EMC88569.1 - 2.1e-97 326.4 0.0 2.5e-97 326.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme TssD PF17642.1 EMC88569.1 - 0.048 13.5 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Hemolysin coregulated protein Hcp (TssD) DnaJ_C PF01556.18 EMC88570.1 - 1.5e-44 151.6 0.9 2e-44 151.2 0.9 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EMC88570.1 - 1.4e-26 92.4 1.4 2.3e-26 91.7 1.4 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EMC88570.1 - 3.5e-15 56.1 19.1 6.5e-15 55.2 19.1 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EMC88570.1 - 0.0031 17.4 11.8 0.063 13.2 1.3 2.9 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein RseC_MucC PF04246.12 EMC88570.1 - 0.049 13.6 0.8 0.12 12.3 0.8 1.6 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC zf-RING_10 PF16685.5 EMC88570.1 - 0.24 11.6 11.5 0.48 10.6 6.9 2.4 1 1 1 2 2 2 0 zinc RING finger of MSL2 HypA PF01155.19 EMC88570.1 - 0.35 10.9 9.7 2.2 8.3 0.5 2.4 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TackOD1 PF18551.1 EMC88570.1 - 0.4 10.3 8.3 1.4 8.6 2.7 2.2 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 zf_CopZ PF18423.1 EMC88570.1 - 0.68 9.9 5.2 14 5.7 0.4 2.7 2 0 0 2 2 2 0 Zinc binding domain WD40 PF00400.32 EMC88571.1 - 1.2e-42 143.1 25.0 1.9e-09 38.0 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC88571.1 - 2e-24 85.7 1.7 8.2e-06 26.0 0.0 6.4 2 1 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMC88571.1 - 1.8e-08 33.7 3.7 0.022 13.7 0.0 4.8 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 EMC88571.1 - 2.1e-06 26.6 1.9 0.78 8.2 0.0 3.7 1 1 1 3 3 3 3 Cytochrome D1 heme domain Nup160 PF11715.8 EMC88571.1 - 9.5e-06 24.5 0.1 0.017 13.8 0.0 2.7 2 1 1 3 3 3 2 Nucleoporin Nup120/160 PD40 PF07676.12 EMC88571.1 - 0.00011 22.0 0.1 1.4 9.0 0.0 3.5 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat HPS3_N PF14761.6 EMC88571.1 - 0.00037 20.1 0.0 0.14 11.7 0.0 3.0 3 0 0 3 3 3 1 Hermansky-Pudlak syndrome 3 WD40_like PF17005.5 EMC88571.1 - 0.00077 18.9 0.1 0.5 9.6 0.0 3.2 2 1 1 3 3 3 1 WD40-like domain GSDH PF07995.11 EMC88571.1 - 0.0046 16.3 0.0 0.42 9.9 0.0 2.4 1 1 0 2 2 2 1 Glucose / Sorbosone dehydrogenase Frtz PF11768.8 EMC88571.1 - 0.0047 15.3 0.0 0.016 13.5 0.0 1.8 1 1 1 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz DUF2415 PF10313.9 EMC88571.1 - 0.028 14.4 0.0 0.22 11.5 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein domain (DUF2415) PQQ PF01011.21 EMC88571.1 - 0.028 14.3 2.8 7.2 6.7 0.0 4.0 4 0 0 4 4 4 0 PQQ enzyme repeat PALB2_WD40 PF16756.5 EMC88571.1 - 0.051 12.5 0.7 3.6 6.4 0.1 2.9 2 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Lipocalin PF00061.23 EMC88572.1 - 6.2e-17 62.1 0.3 6.7e-17 62.0 0.3 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Aconitase PF00330.20 EMC88573.1 - 1.6e-151 505.4 0.0 2e-136 455.6 0.0 2.1 2 0 0 2 2 2 2 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EMC88573.1 - 5.3e-41 140.0 0.0 8.9e-41 139.3 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain APH PF01636.23 EMC88574.1 - 7.9e-24 84.9 0.0 1.1e-23 84.4 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EMC88574.1 - 0.044 13.1 0.0 0.062 12.6 0.0 1.1 1 0 0 1 1 1 0 Ecdysteroid kinase Kdo PF06293.14 EMC88574.1 - 0.057 12.8 0.0 0.093 12.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Proteasome PF00227.26 EMC88575.1 - 2.5e-55 186.9 0.0 3.3e-55 186.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EMC88575.1 - 8.3e-14 50.9 0.1 1.4e-13 50.3 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature TRP_N PF14558.6 EMC88575.1 - 0.11 12.9 0.1 0.58 10.5 0.0 1.9 2 0 0 2 2 2 0 ML-like domain Phenol_monoox PF04663.12 EMC88575.1 - 0.12 12.5 0.1 0.28 11.4 0.1 1.5 1 0 0 1 1 1 0 Phenol hydroxylase conserved region Neur_chan_LBD PF02931.23 EMC88576.1 - 2e-72 243.1 0.6 2.6e-72 242.8 0.6 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC88576.1 - 1.1e-64 218.8 13.2 3.1e-50 171.5 10.3 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_memb PF02932.16 EMC88577.1 - 7.7e-94 314.2 5.8 9.4e-94 313.9 5.8 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 EMC88577.1 - 6.7e-74 248.0 2.0 1.1e-73 247.3 2.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain FtsK_alpha PF17854.1 EMC88577.1 - 0.13 12.4 0.0 0.36 11.0 0.0 1.7 1 0 0 1 1 1 0 FtsK alpha domain Neur_chan_memb PF02932.16 EMC88578.1 - 3.2e-89 299.1 2.8 4.2e-89 298.7 2.8 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 EMC88578.1 - 2.8e-71 239.4 2.2 4.7e-71 238.7 2.2 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF2417 PF10329.9 EMC88578.1 - 0.02 14.3 6.0 0.035 13.5 3.9 2.0 2 0 0 2 2 2 0 Region of unknown function (DUF2417) Phage_HK97_TLTM PF06120.11 EMC88578.1 - 0.18 11.0 0.1 0.25 10.5 0.1 1.2 1 0 0 1 1 1 0 Tail length tape measure protein UQ_con PF00179.26 EMC88579.1 - 5.6e-11 42.3 0.0 6.2e-10 38.9 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EMC88579.1 - 0.0053 16.5 0.0 0.0089 15.7 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic E2 family B Josephin PF02099.17 EMC88579.1 - 0.046 13.8 0.1 0.066 13.3 0.0 1.4 1 1 0 1 1 1 0 Josephin TraC_F_IV PF11130.8 EMC88579.1 - 0.12 12.0 0.0 5 6.7 0.0 2.2 2 0 0 2 2 2 0 F pilus assembly Type-IV secretion system for plasmid transfer TPR_MLP1_2 PF07926.12 EMC88579.1 - 0.53 10.4 4.2 0.57 10.3 0.5 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein KIAA1430 PF13879.6 EMC88579.1 - 7.7 7.3 9.9 3.1 8.6 0.7 2.9 2 1 1 3 3 3 0 KIAA1430 homologue FIST_C PF10442.9 EMC88580.1 - 1.8e-12 47.3 0.0 3.8e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 FIST C domain FIST PF08495.10 EMC88580.1 - 2.6e-05 24.3 0.0 0.0076 16.3 0.0 2.1 2 0 0 2 2 2 2 FIST N domain Toprim_3 PF13362.6 EMC88580.1 - 0.05 14.0 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 Toprim domain DUF2759 PF10958.8 EMC88580.1 - 1.2 8.9 3.2 1.5 8.6 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2759) EGF PF00008.27 EMC88582.1 - 0.0019 18.5 5.9 0.0019 18.5 5.9 1.8 2 0 0 2 2 2 1 EGF-like domain EGF_2 PF07974.13 EMC88582.1 - 0.013 15.8 3.1 0.013 15.8 3.1 2.2 3 1 0 3 3 3 0 EGF-like domain Laminin_EGF PF00053.24 EMC88582.1 - 0.08 13.1 0.7 0.08 13.1 0.7 1.8 2 0 0 2 2 2 0 Laminin EGF domain Ion_trans PF00520.31 EMC88583.1 - 3.3e-07 29.8 7.0 4.8e-07 29.3 7.0 1.1 1 0 0 1 1 1 1 Ion transport protein zf-C4H2 PF10146.9 EMC88583.1 - 0.098 13.0 0.4 0.15 12.4 0.4 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein Peptidase_S10 PF00450.22 EMC88583.1 - 0.28 10.5 0.8 0.53 9.6 0.8 1.3 1 0 0 1 1 1 0 Serine carboxypeptidase MoaF_C PF17409.2 EMC88584.1 - 0.16 11.6 7.4 0.41 10.3 7.3 1.7 1 1 0 1 1 1 0 MoaF C-terminal domain ETF PF01012.21 EMC88585.1 - 4.5e-43 147.3 0.1 6.3e-43 146.8 0.1 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 EMC88585.1 - 9.6e-38 128.1 1.2 1.5e-37 127.5 0.2 1.8 2 0 0 2 2 2 1 Electron transfer flavoprotein FAD-binding domain HATPase_c PF02518.26 EMC88588.1 - 1.7e-10 41.4 0.0 4.5e-09 36.8 0.0 2.5 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Carb_anhydrase PF00194.21 EMC88589.1 - 1.9e-82 276.6 0.0 2.1e-82 276.5 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase V-set PF07686.17 EMC88590.1 - 1.3e-12 47.9 0.1 1.4e-12 47.7 0.1 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC88590.1 - 6.5e-07 29.9 0.2 9.4e-07 29.4 0.2 1.2 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC88590.1 - 0.00014 21.9 0.2 0.00059 20.0 0.2 1.8 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC88590.1 - 0.00021 21.3 0.1 0.00098 19.1 0.1 1.8 1 1 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 EMC88591.1 - 4.4e-14 52.6 0.0 5.2e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC88591.1 - 4.1e-07 30.5 0.2 6.4e-07 29.9 0.2 1.2 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC88591.1 - 0.00096 19.2 0.0 0.0038 17.3 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC88591.1 - 0.057 13.6 0.5 0.29 11.3 0.5 1.9 1 1 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 EMC88592.1 - 1.4e-14 54.2 0.3 1.6e-14 54.0 0.3 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC88592.1 - 2.4e-07 31.2 0.3 3.9e-07 30.6 0.3 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC88592.1 - 0.00032 20.7 0.1 0.0015 18.5 0.1 1.8 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC88592.1 - 0.018 15.2 0.7 0.067 13.4 0.7 1.8 1 1 0 1 1 1 0 Immunoglobulin domain Ig_2 PF13895.6 EMC88592.1 - 0.028 14.7 0.4 0.062 13.6 0.4 1.5 1 1 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 EMC88593.1 - 5.7e-14 52.2 0.6 6.3e-14 52.1 0.6 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC88593.1 - 1.4e-06 28.8 0.9 3.3e-06 27.6 0.9 1.5 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC88593.1 - 0.0003 20.8 0.1 0.00088 19.3 0.1 1.8 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC88593.1 - 0.0017 18.4 0.6 0.008 16.3 0.6 1.8 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC88594.1 - 1.1e-14 54.5 0.1 1.3e-14 54.3 0.1 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC88594.1 - 2.3e-06 28.1 0.3 4.3e-06 27.2 0.3 1.4 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC88594.1 - 0.0064 16.5 0.0 0.019 15.0 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC88594.1 - 0.032 14.4 0.4 0.075 13.2 0.4 1.6 1 1 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 EMC88595.1 - 2e-15 56.9 0.2 2.3e-15 56.7 0.2 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC88595.1 - 1.4e-07 32.0 0.6 2.6e-07 31.1 0.6 1.3 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC88595.1 - 0.00023 21.3 0.2 0.00049 20.2 0.2 1.5 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC88595.1 - 0.00035 20.6 0.1 0.0009 19.3 0.1 1.7 1 1 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 EMC88596.1 - 3.1e-08 33.8 0.1 3.4e-08 33.6 0.1 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC88596.1 - 0.016 15.8 0.4 0.03 14.9 0.4 1.5 1 1 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 EMC88597.1 - 4.5e-15 55.8 0.1 5.2e-15 55.6 0.1 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC88597.1 - 1.5e-07 31.9 0.5 2.8e-07 31.0 0.5 1.4 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC88597.1 - 4.4e-05 23.5 0.1 0.0001 22.3 0.1 1.6 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC88597.1 - 0.00023 21.3 0.2 0.00044 20.4 0.2 1.4 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC88598.1 - 1.9e-17 63.4 0.1 2.4e-17 63.1 0.1 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC88598.1 - 4e-07 30.5 1.7 4.3e-07 30.4 0.3 1.8 2 1 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 EMC88598.1 - 1.2e-05 25.3 0.2 5.2e-05 23.3 0.1 2.0 1 1 1 2 2 2 1 Immunoglobulin domain I-set PF07679.16 EMC88598.1 - 6.2e-05 23.0 0.0 0.00012 22.1 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC88598.1 - 0.029 14.7 2.9 0.07 13.5 2.1 2.0 1 1 0 1 1 1 0 Immunoglobulin domain CHCH PF06747.13 EMC88599.1 - 2e-07 31.0 5.7 2e-07 31.0 5.7 1.6 2 0 0 2 2 2 1 CHCH domain CX9C PF16860.5 EMC88599.1 - 0.077 13.0 3.2 0.13 12.2 3.2 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Peptidase_M10 PF00413.24 EMC88600.1 - 4.6e-56 189.0 0.0 7.4e-56 188.4 0.0 1.3 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 EMC88600.1 - 5.3e-44 147.9 13.8 3.1e-12 46.2 1.0 4.5 4 0 0 4 4 4 4 Hemopexin DUF4953 PF16313.5 EMC88600.1 - 0.0028 16.9 0.2 0.0045 16.3 0.2 1.2 1 0 0 1 1 1 1 Met-zincin Astacin PF01400.24 EMC88600.1 - 0.0033 17.1 0.3 0.84 9.2 0.1 2.2 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.6 EMC88600.1 - 0.0041 17.6 0.0 0.0066 17.0 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EMC88600.1 - 0.0083 16.3 0.0 0.012 15.7 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 EMC88600.1 - 0.0087 15.7 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M43 PF05572.13 EMC88600.1 - 0.029 14.3 0.1 0.049 13.5 0.1 1.3 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A Kelch_6 PF13964.6 EMC88600.1 - 0.096 13.0 0.3 0.99 9.8 0.0 2.8 3 0 0 3 3 3 0 Kelch motif SNF5 PF04855.12 EMC88601.1 - 1.4e-56 192.0 0.7 1.1e-29 104.0 0.0 2.2 1 1 1 2 2 2 2 SNF5 / SMARCB1 / INI1 DUF1679 PF07914.11 EMC88601.1 - 0.005 15.8 0.0 0.0074 15.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) DER1 PF04511.15 EMC88602.1 - 1.5e-66 224.0 13.7 1.7e-66 223.8 13.7 1.0 1 0 0 1 1 1 1 Der1-like family Oleosin PF01277.17 EMC88602.1 - 0.17 11.6 2.4 0.31 10.8 0.0 2.2 1 1 1 2 2 2 0 Oleosin Sugar_tr PF00083.24 EMC88603.1 - 2.8e-93 313.2 21.6 3.2e-93 313.1 21.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMC88603.1 - 3.5e-24 85.4 46.2 2e-22 79.6 23.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMC88604.1 - 2.3e-28 99.3 9.0 2.5e-28 99.2 9.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMC88604.1 - 7.8e-16 57.9 6.6 8.6e-16 57.8 6.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EMC88604.1 - 0.0002 20.4 2.3 0.00024 20.1 2.3 1.1 1 0 0 1 1 1 1 MFS_1 like family MFS_2 PF13347.6 EMC88604.1 - 0.0022 16.6 0.5 0.0032 16.1 0.5 1.2 1 0 0 1 1 1 1 MFS/sugar transport protein Sugar_tr PF00083.24 EMC88605.1 - 1.3e-95 320.9 22.4 1.5e-95 320.7 22.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMC88605.1 - 5.5e-29 101.2 28.3 6.4e-20 71.4 1.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 EMC88605.1 - 0.014 13.8 3.2 1.2 7.5 0.6 2.3 2 0 0 2 2 2 0 Transmembrane secretion effector PUCC PF03209.15 EMC88605.1 - 0.7 8.8 16.4 0.076 12.0 3.3 2.2 2 0 0 2 2 2 0 PUCC protein DEAD PF00270.29 EMC88606.1 - 8.2e-42 142.9 0.0 1.4e-41 142.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC88606.1 - 4.4e-28 97.9 0.2 2.8e-26 92.0 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC88606.1 - 3.8e-11 43.3 0.0 7.3e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 EMC88606.1 - 0.0018 18.0 0.0 0.0029 17.3 0.0 1.2 1 0 0 1 1 1 1 SWI2/SNF2 ATPase T4SS-DNA_transf PF02534.14 EMC88606.1 - 0.003 16.4 0.0 0.0044 15.9 0.0 1.2 1 0 0 1 1 1 1 Type IV secretory system Conjugative DNA transfer AAA_22 PF13401.6 EMC88606.1 - 0.0096 16.2 0.1 1 9.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EMC88606.1 - 0.051 13.9 0.0 0.16 12.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain IMS_HHH PF11798.8 EMC88606.1 - 0.081 13.3 0.1 0.23 11.9 0.1 1.8 1 0 0 1 1 1 0 IMS family HHH motif DUF4800 PF16057.5 EMC88606.1 - 0.098 11.9 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4800) GST_C PF00043.25 EMC88607.1 - 3.6e-08 33.5 0.1 6.1e-08 32.8 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EMC88607.1 - 2.5e-06 27.6 0.1 1e-05 25.6 0.0 2.0 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EMC88607.1 - 1e-05 25.5 0.0 2.2e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EMC88607.1 - 0.00012 22.4 0.1 0.00082 19.7 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EMC88607.1 - 0.077 13.4 0.0 0.16 12.4 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EMC88608.1 - 4.3e-08 33.3 0.0 9.2e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EMC88608.1 - 1e-05 25.4 0.3 3.1e-05 23.9 0.1 2.0 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EMC88608.1 - 9.8e-05 22.6 0.0 0.00021 21.5 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EMC88608.1 - 0.00015 22.1 0.0 0.0003 21.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EMC88608.1 - 0.00035 20.7 0.0 0.0013 18.9 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain DUF2420 PF10336.9 EMC88608.1 - 0.07 13.2 0.1 1.5 8.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2420) SH3_2 PF07653.17 EMC88609.1 - 3.3e-25 87.5 0.1 4.5e-13 48.6 0.0 2.2 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 EMC88609.1 - 4.8e-22 77.3 0.3 1.2e-16 60.1 0.1 2.3 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 EMC88609.1 - 5.9e-16 58.1 1.1 1.7e-08 34.2 0.1 2.6 3 0 0 3 3 3 2 Variant SH3 domain hSH3 PF14603.6 EMC88609.1 - 0.0016 18.8 0.0 0.004 17.5 0.0 1.7 2 0 0 2 2 2 1 Helically-extended SH3 domain SH2 PF00017.24 EMC88610.1 - 4.5e-22 77.9 0.0 5.5e-22 77.7 0.0 1.1 1 0 0 1 1 1 1 SH2 domain SH2_2 PF14633.6 EMC88610.1 - 0.04 13.3 0.0 0.27 10.6 0.0 1.9 1 1 0 1 1 1 0 SH2 domain Kelch_1 PF01344.25 EMC88611.1 - 6e-49 163.4 4.9 5.2e-13 48.4 0.0 5.5 5 0 0 5 5 5 5 Kelch motif Kelch_6 PF13964.6 EMC88611.1 - 6.2e-43 143.7 0.3 3.7e-09 36.5 0.0 5.6 4 1 1 5 5 5 5 Kelch motif BTB PF00651.31 EMC88611.1 - 4.6e-27 94.4 1.5 9.7e-25 87.0 0.2 2.4 1 1 1 2 2 2 2 BTB/POZ domain Kelch_2 PF07646.15 EMC88611.1 - 4.4e-24 83.5 5.3 1.3e-05 24.9 0.0 6.0 5 2 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 EMC88611.1 - 5.2e-22 77.6 0.7 3.1e-07 30.5 0.0 5.5 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_4 PF13418.6 EMC88611.1 - 7e-17 61.2 0.1 0.085 12.9 0.0 5.5 4 1 1 5 5 5 5 Galactose oxidase, central domain BACK PF07707.15 EMC88611.1 - 5.9e-15 55.2 0.2 1.7e-14 53.8 0.2 1.8 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_5 PF13854.6 EMC88611.1 - 3.3e-08 33.3 1.3 0.099 12.7 0.0 5.7 6 0 0 6 6 6 1 Kelch motif Med15 PF09606.10 EMC88612.1 - 5.2e-183 610.8 162.8 6.5e-183 610.5 162.8 1.0 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal mit_SMPDase PF14724.6 EMC88613.1 - 0 1506.0 4.5 0 1505.9 4.5 1.0 1 0 0 1 1 1 1 Mitochondrial-associated sphingomyelin phosphodiesterase Pan3_PK PF18101.1 EMC88613.1 - 0.083 12.9 0.2 7.2 6.6 0.1 3.0 2 1 1 3 3 3 0 Pan3 Pseudokinase domain DEC-1_N PF04625.13 EMC88613.1 - 0.18 10.8 0.5 0.29 10.1 0.5 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region G_glu_transpept PF01019.21 EMC88614.1 - 1.5e-134 449.6 0.0 1.8e-134 449.4 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase G_glu_transpept PF01019.21 EMC88615.1 - 1.9e-174 581.2 0.0 2.2e-174 581.0 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase LRR_4 PF12799.7 EMC88616.1 - 0.002 18.5 5.7 0.044 14.2 0.9 2.7 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EMC88616.1 - 0.019 15.0 2.4 6.5 7.1 0.1 2.6 2 0 0 2 2 2 0 Leucine Rich repeat LSM PF01423.22 EMC88617.1 - 6.9e-16 57.7 0.2 9.5e-16 57.3 0.2 1.2 1 0 0 1 1 1 1 LSM domain Kringle PF00051.18 EMC88617.1 - 0.15 12.4 0.1 0.23 11.8 0.1 1.3 1 0 0 1 1 1 0 Kringle domain Guanylate_cyc_2 PF09778.9 EMC88618.1 - 4.2e-94 313.8 3.5 4.8e-94 313.6 3.5 1.0 1 0 0 1 1 1 1 Guanylylate cyclase Peptidase_C39_2 PF13529.6 EMC88618.1 - 3.9e-09 37.2 0.1 1.4e-08 35.4 0.1 1.9 1 1 0 1 1 1 1 Peptidase_C39 like family Peptidase_C70 PF12385.8 EMC88618.1 - 5e-07 29.8 0.1 0.027 14.4 0.0 2.6 2 1 0 2 2 2 2 Papain-like cysteine protease AvrRpt2 DUF3335 PF11814.8 EMC88618.1 - 3e-05 23.6 0.2 0.021 14.3 0.1 2.2 2 0 0 2 2 2 2 Peptidase_C39 like family Peptidase_C39 PF03412.15 EMC88618.1 - 0.0004 20.2 0.1 0.0064 16.3 0.2 2.4 2 1 0 2 2 2 1 Peptidase C39 family PyocinActivator PF11112.8 EMC88618.1 - 0.13 12.4 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 Pyocin activator protein PrtN TMEM52 PF14979.6 EMC88618.1 - 0.22 11.4 5.7 0.42 10.5 5.7 1.5 1 0 0 1 1 1 0 Transmembrane 52 CN_hydrolase PF00795.22 EMC88619.1 - 3.9e-60 203.4 0.0 4.8e-60 203.1 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase 7tm_1 PF00001.21 EMC88620.1 - 1.2e-46 159.1 16.2 1.5e-46 158.9 16.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC88620.1 - 2.6e-08 33.9 9.1 3.6e-08 33.5 9.1 1.2 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 EMC88620.1 - 8.1e-08 31.9 20.0 1.2e-06 28.1 20.0 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC88620.1 - 6.5e-07 29.2 15.0 6.5e-07 29.2 15.0 2.3 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx TMF_DNA_bd PF12329.8 EMC88621.1 - 0.008 16.2 1.4 0.008 16.2 1.4 9.7 8 2 2 10 10 10 5 TATA element modulatory factor 1 DNA binding RhoGAP PF00620.27 EMC88622.1 - 7e-50 168.8 0.2 1.5e-48 164.4 0.0 2.7 2 0 0 2 2 2 1 RhoGAP domain Bcr-Abl_Oligo PF09036.10 EMC88622.1 - 2.9e-37 126.5 1.2 2.9e-37 126.5 1.2 2.7 2 0 0 2 2 2 1 Bcr-Abl oncoprotein oligomerisation domain RhoGEF PF00621.20 EMC88622.1 - 2.1e-34 119.3 0.9 4.9e-34 118.2 0.9 1.7 1 0 0 1 1 1 1 RhoGEF domain C2 PF00168.30 EMC88622.1 - 1.1e-06 28.9 0.0 2.8e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 C2 domain PH PF00169.29 EMC88622.1 - 0.0046 17.5 3.1 0.015 15.8 0.7 2.9 2 1 0 2 2 2 1 PH domain IQ_SEC7_PH PF16453.5 EMC88622.1 - 0.02 14.9 0.0 0.064 13.2 0.0 1.8 1 0 0 1 1 1 0 PH domain Ras PF00071.22 EMC88623.1 - 9.9e-45 152.0 0.2 1.4e-44 151.6 0.2 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC88623.1 - 2.1e-30 105.4 0.0 4e-30 104.5 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC88623.1 - 1.3e-14 54.1 0.0 1.8e-14 53.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC88623.1 - 4.1e-07 30.1 0.0 6.5e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMC88623.1 - 7.9e-05 22.1 0.0 0.0001 21.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EMC88623.1 - 0.0031 17.1 0.0 0.15 11.6 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain TniB PF05621.11 EMC88623.1 - 0.0092 15.4 0.0 0.021 14.3 0.0 1.5 1 0 0 1 1 1 1 Bacterial TniB protein FeoB_N PF02421.18 EMC88623.1 - 0.054 13.0 0.0 0.43 10.1 0.0 2.2 1 1 0 1 1 1 0 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EMC88623.1 - 0.17 11.8 0.0 4.2 7.2 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase HEAT_2 PF13646.6 EMC88624.1 - 6.1e-18 65.0 10.7 7.3e-08 32.7 0.4 4.1 2 1 2 4 4 4 4 HEAT repeats HEAT PF02985.22 EMC88624.1 - 6.9e-14 50.8 3.6 0.28 11.5 0.0 7.1 7 0 0 7 7 7 4 HEAT repeat Cnd1 PF12717.7 EMC88624.1 - 5.7e-12 46.0 1.1 0.0017 18.4 0.0 4.0 1 1 3 4 4 4 4 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 EMC88624.1 - 9.7e-12 44.5 8.7 0.002 18.1 0.0 6.8 8 0 0 8 8 8 3 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.20 EMC88624.1 - 1.2e-11 43.9 0.5 1.8e-08 33.4 0.5 2.8 1 1 0 1 1 1 1 Adaptin N terminal region HEAT_EZ PF13513.6 EMC88624.1 - 6.8e-08 32.9 6.1 0.0063 17.0 0.2 6.1 5 2 2 7 7 7 2 HEAT-like repeat Proteasom_PSMB PF10508.9 EMC88624.1 - 2.3e-06 26.4 2.5 0.17 10.3 0.2 3.1 2 1 0 3 3 3 2 Proteasome non-ATPase 26S subunit CLASP_N PF12348.8 EMC88624.1 - 8.1e-05 22.3 0.1 0.4 10.2 0.0 3.6 1 1 2 4 4 4 2 CLASP N terminal Arm_2 PF04826.13 EMC88624.1 - 0.00018 21.0 0.0 0.22 10.9 0.0 2.4 1 1 1 2 2 2 2 Armadillo-like DUF3636 PF12331.8 EMC88624.1 - 0.0016 18.3 0.9 5.4 6.8 0.0 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF3636) RTP1_C1 PF10363.9 EMC88624.1 - 0.0018 18.4 0.3 0.4 10.9 0.1 3.0 2 1 1 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 WAPL PF07814.13 EMC88624.1 - 0.034 12.9 0.2 0.051 12.4 0.2 1.3 1 0 0 1 1 1 0 Wings apart-like protein regulation of heterochromatin RICTOR_N PF14664.6 EMC88624.1 - 0.034 13.1 0.9 3.8 6.4 0.1 3.2 3 1 1 4 4 4 0 Rapamycin-insensitive companion of mTOR, N-term Tti2 PF10521.9 EMC88624.1 - 0.072 12.6 0.5 16 5.0 0.0 3.0 2 1 1 3 3 3 0 Tti2 family MMS19_N PF14500.6 EMC88624.1 - 0.072 12.7 0.9 5.5 6.5 0.1 3.5 4 1 1 5 5 5 0 Dos2-interacting transcription regulator of RNA-Pol-II G-alpha PF00503.20 EMC88625.1 - 3.9e-119 398.0 1.0 4.5e-119 397.7 1.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EMC88625.1 - 1.1e-16 60.8 0.3 7.7e-11 41.7 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EMC88625.1 - 0.00021 20.7 4.3 0.016 14.6 0.4 2.5 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMC88625.1 - 0.0031 17.6 0.3 1.2 9.2 0.1 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase TniB PF05621.11 EMC88625.1 - 0.012 15.1 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Roc PF08477.13 EMC88625.1 - 0.013 15.7 1.4 1.8 8.8 0.2 2.6 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 EMC88625.1 - 0.013 15.2 0.0 0.034 13.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF2951 PF11166.8 EMC88625.1 - 0.067 13.4 0.3 14 5.9 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) AAA_16 PF13191.6 EMC88625.1 - 0.12 12.7 0.0 0.2 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain SSF PF00474.17 EMC88626.1 - 2.9e-166 553.3 24.6 4.5e-166 552.7 24.6 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family 14-3-3 PF00244.20 EMC88627.1 - 4.2e-103 343.6 9.7 4.8e-103 343.4 9.7 1.0 1 0 0 1 1 1 1 14-3-3 protein DUF722 PF05263.11 EMC88627.1 - 0.033 14.4 1.2 0.086 13.1 0.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF722) CodY PF06018.14 EMC88627.1 - 0.053 13.0 0.2 0.088 12.3 0.2 1.3 1 0 0 1 1 1 0 CodY GAF-like domain DUF3504 PF12012.8 EMC88627.1 - 0.092 12.7 0.4 0.16 11.9 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3504) SIX1_SD PF16878.5 EMC88628.1 - 7.4e-13 49.0 0.3 7.4e-13 49.0 0.3 2.0 3 0 0 3 3 3 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeodomain PF00046.29 EMC88628.1 - 3.4e-09 36.4 2.1 3.4e-09 36.4 2.1 1.9 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 EMC88628.1 - 8.4e-08 32.0 1.1 2.3e-07 30.6 0.2 2.1 2 0 0 2 2 2 1 Homeobox KN domain HTH_Tnp_1 PF01527.20 EMC88628.1 - 0.011 16.1 0.4 0.028 14.7 0.4 1.7 1 0 0 1 1 1 0 Transposase CENP-B_N PF04218.13 EMC88628.1 - 0.11 12.1 0.2 0.44 10.2 0.0 2.1 3 0 0 3 3 3 0 CENP-B N-terminal DNA-binding domain IML1 PF12257.8 EMC88629.1 - 8.8e-114 379.4 0.2 1.4e-113 378.8 0.2 1.3 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 EMC88629.1 - 3.8e-10 39.7 0.0 1.6e-09 37.7 0.0 2.1 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FGGY_N PF00370.21 EMC88629.1 - 0.086 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain PS_Dcarbxylase PF02666.15 EMC88630.1 - 1.3e-67 227.2 0.0 2e-67 226.7 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Tantalus PF15386.6 EMC88630.1 - 2.9e-13 49.7 1.0 7.8e-13 48.3 1.0 1.7 1 0 0 1 1 1 1 Drosophila Tantalus-like MMR_HSR1_Xtn PF16897.5 EMC88631.1 - 1.2e-45 153.9 0.3 2.1e-45 153.1 0.3 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 EMC88631.1 - 7.1e-25 86.8 0.1 1.6e-24 85.7 0.1 1.6 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 EMC88631.1 - 1.8e-19 69.9 0.1 3.9e-19 68.8 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EMC88631.1 - 9.6e-11 41.4 0.1 1.2e-09 37.9 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 EMC88631.1 - 0.0032 16.5 0.3 0.023 13.7 0.1 2.0 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 EMC88631.1 - 0.0046 17.0 0.3 2.6 8.1 0.2 2.3 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.27 EMC88631.1 - 0.0055 16.3 0.1 4.1 6.9 0.0 3.7 2 2 1 3 3 3 1 Elongation factor Tu GTP binding domain zf-C2H2_assoc3 PF16637.5 EMC88632.1 - 5.7e-29 100.1 6.6 5.7e-29 100.1 6.6 2.1 3 0 0 3 3 1 1 Putative zinc-finger between two C2H2 zinc-fingers on Patz zf-C2H2_4 PF13894.6 EMC88632.1 - 7.3e-25 85.5 44.8 0.0007 20.2 0.3 8.1 8 0 0 8 8 8 6 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC88632.1 - 2.1e-22 78.3 51.0 9e-05 22.7 0.8 8.2 8 0 0 8 8 7 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC88632.1 - 7.6e-14 51.4 53.2 2.6e-06 27.6 2.2 9.2 10 0 0 10 10 9 4 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EMC88632.1 - 4.3e-11 42.8 22.6 0.52 10.7 0.4 8.1 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMC88632.1 - 5.1e-10 39.1 43.7 1.2e-05 25.1 3.1 8.2 8 0 0 8 8 8 3 C2H2-type zinc finger zf-met PF12874.7 EMC88632.1 - 1.5e-09 37.9 24.3 0.35 11.3 0.0 8.0 8 0 0 8 8 8 3 Zinc-finger of C2H2 type zf-Di19 PF05605.12 EMC88632.1 - 0.0002 21.6 29.7 0.044 14.1 1.1 5.8 4 1 1 6 6 6 3 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.10 EMC88632.1 - 0.00037 20.5 27.3 0.059 13.5 0.5 5.7 4 1 2 6 6 6 3 Zinc ribbon domain ROS_MUCR PF05443.11 EMC88632.1 - 0.011 15.7 0.3 1.3 9.1 0.0 2.7 3 0 0 3 3 2 0 ROS/MUCR transcriptional regulator protein zf-C2H2_8 PF15909.5 EMC88632.1 - 0.015 15.6 14.6 0.029 14.7 4.8 3.3 2 1 1 3 3 3 0 C2H2-type zinc ribbon zf-C2H2_3rep PF18868.1 EMC88632.1 - 0.016 15.9 18.7 26 5.5 3.8 5.5 1 1 4 5 5 5 0 Zinc finger C2H2-type, 3 repeats ARS2 PF04959.13 EMC88632.1 - 0.045 14.1 0.1 0.045 14.1 0.1 4.1 4 1 1 5 5 5 0 Arsenite-resistance protein 2 zf_C2H2_13 PF18508.1 EMC88632.1 - 0.045 13.3 6.3 0.54 9.9 0.1 3.7 3 0 0 3 3 3 0 Zinc finger domain zf_UBZ PF18439.1 EMC88632.1 - 0.051 13.2 21.4 6.5 6.4 0.1 7.6 8 0 0 8 8 8 0 Ubiquitin-Binding Zinc Finger DUF629 PF04780.12 EMC88632.1 - 0.063 11.8 2.9 1.9 7.0 1.0 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF629) zf-WRNIP1_ubi PF18279.1 EMC88632.1 - 0.067 13.8 1.5 29 5.6 0.0 4.5 3 0 0 3 3 3 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-C2H2_9 PF16293.5 EMC88632.1 - 0.098 12.5 9.2 1.6 8.6 0.0 5.0 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) Zn-C2H2_12 PF18112.1 EMC88632.1 - 0.46 11.0 9.5 0.51 10.9 0.1 4.7 5 0 0 5 5 5 0 Autophagy receptor zinc finger-C2H2 domain DZR PF12773.7 EMC88632.1 - 0.87 9.7 27.5 2.2 8.4 0.2 4.7 4 1 1 5 5 4 0 Double zinc ribbon zf-C2H2_2 PF12756.7 EMC88632.1 - 3.2 8.1 28.6 26 5.2 0.2 6.9 3 1 4 7 7 6 0 C2H2 type zinc-finger (2 copies) GAGA PF09237.11 EMC88632.1 - 4 7.3 22.3 4.5 7.2 0.5 5.8 6 1 1 7 7 7 0 GAGA factor XPA_N PF01286.18 EMC88632.1 - 5.7 7.1 16.2 17 5.6 0.0 6.3 7 0 0 7 7 7 0 XPA protein N-terminal zf-FPG_IleRS PF06827.14 EMC88632.1 - 7.7 6.5 17.1 48 3.9 2.2 6.2 6 1 0 6 6 6 0 Zinc finger found in FPG and IleRS AT_hook PF02178.19 EMC88632.1 - 8.5 6.6 13.7 0.077 12.9 4.1 2.4 2 0 0 2 2 2 0 AT hook motif zf-C2H2_11 PF16622.5 EMC88632.1 - 9.4 6.1 24.8 0.42 10.4 0.1 6.0 6 0 0 6 6 6 0 zinc-finger C2H2-type COX5B PF01215.19 EMC88632.1 - 9.6 5.9 6.0 2.6 7.8 0.2 2.8 3 0 0 3 3 3 0 Cytochrome c oxidase subunit Vb ABC2_membrane_3 PF12698.7 EMC88633.1 - 0.089 11.9 0.0 0.1 11.7 0.0 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein zf-C3HC4_3 PF13920.6 EMC88634.1 - 7.4e-11 41.7 5.4 1e-10 41.3 5.4 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC88634.1 - 1.8e-10 40.5 7.5 2.5e-10 40.0 7.5 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC88634.1 - 6.5e-10 39.2 9.7 8.8e-10 38.8 9.7 1.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMC88634.1 - 3.4e-09 36.4 8.9 5.1e-09 35.8 8.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC88634.1 - 2.2e-07 30.6 6.7 3.2e-07 30.1 6.7 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EMC88634.1 - 3e-07 30.4 6.4 3.5e-06 26.9 7.3 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMC88634.1 - 6.4e-07 29.2 6.4 9.3e-07 28.7 6.4 1.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EMC88634.1 - 9.7e-06 25.8 7.0 1.6e-05 25.1 7.0 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EMC88634.1 - 8.4e-05 22.6 2.6 0.00012 22.0 2.6 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 EMC88634.1 - 0.00049 20.2 7.5 0.00073 19.6 7.5 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Baculo_IE-1 PF05290.11 EMC88634.1 - 0.00062 19.7 2.7 0.00094 19.1 2.7 1.2 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) Rtf2 PF04641.12 EMC88634.1 - 0.011 15.2 0.2 0.013 14.8 0.2 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger zf-UDP PF14569.6 EMC88634.1 - 0.015 15.4 1.5 0.04 14.0 1.5 1.7 1 1 0 1 1 1 0 Zinc-binding RING-finger zf-RING_4 PF14570.6 EMC88634.1 - 0.025 14.3 5.8 0.057 13.2 5.8 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 EMC88634.1 - 0.16 11.6 5.5 0.25 11.0 5.5 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type IBR PF01485.21 EMC88634.1 - 0.29 11.4 7.5 0.85 9.9 3.3 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain DUF1272 PF06906.11 EMC88634.1 - 1.2 9.3 5.3 3 8.0 5.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1272) zf-RING_11 PF17123.5 EMC88634.1 - 3.2 7.6 9.9 0.32 10.8 5.2 1.8 2 0 0 2 2 2 0 RING-like zinc finger DUF2011 PF09428.10 EMC88635.1 - 0.088 13.1 2.0 0.21 11.9 0.2 2.3 1 1 1 2 2 2 0 Fungal protein of unknown function (DUF2011) RabGAP-TBC PF00566.18 EMC88635.1 - 0.093 12.4 1.6 0.13 11.9 1.6 1.2 1 0 0 1 1 1 0 Rab-GTPase-TBC domain HNF-1B_C PF04812.13 EMC88636.1 - 1.9e-109 365.1 36.0 1.9e-109 365.1 36.0 2.1 2 0 0 2 2 2 1 Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus HNF-1_N PF04814.13 EMC88636.1 - 1.5e-56 192.1 0.2 1.5e-56 192.1 0.2 3.7 2 1 1 4 4 4 1 Hepatocyte nuclear factor 1 (HNF-1), N terminus HNF-1A_C PF04813.12 EMC88636.1 - 3.1e-36 124.0 16.1 3.1e-36 124.0 16.1 3.0 2 1 0 2 2 2 1 Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus Homeodomain PF00046.29 EMC88636.1 - 8.9e-05 22.3 1.8 0.00074 19.3 1.8 2.4 1 1 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC88636.1 - 0.042 13.7 0.0 0.18 11.7 0.0 2.1 1 0 0 1 1 1 0 Homeobox KN domain Peptidase_A22B PF04258.13 EMC88637.1 - 2.2e-94 316.2 9.1 2.9e-94 315.8 9.1 1.1 1 0 0 1 1 1 1 Signal peptide peptidase Acyl-CoA_dh_1 PF00441.24 EMC88638.1 - 1.2e-50 171.6 8.2 1.8e-50 171.0 8.2 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EMC88638.1 - 5.9e-37 126.8 0.2 2.6e-36 124.7 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EMC88638.1 - 6.1e-27 93.7 0.0 1.1e-26 92.8 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EMC88638.1 - 2.4e-24 86.1 5.0 3.7e-24 85.5 5.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 EMC88638.1 - 0.11 12.2 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal DUF743 PF05332.11 EMC88638.1 - 0.16 12.0 0.1 0.31 11.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF743) GMP_PDE_delta PF05351.11 EMC88639.1 - 5.7e-77 257.2 1.3 6.3e-77 257.0 1.3 1.0 1 0 0 1 1 1 1 GMP-PDE, delta subunit Malectin PF11721.8 EMC88640.1 - 5.7e-40 137.1 0.3 5.7e-40 137.1 0.3 1.4 2 0 0 2 2 2 1 Malectin domain Malectin_like PF12819.7 EMC88640.1 - 0.14 11.3 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 Malectin-like domain EF-hand_1 PF00036.32 EMC88641.1 - 6.5e-30 100.4 14.4 3.9e-10 38.5 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EMC88641.1 - 1.4e-25 89.5 5.1 3.6e-15 56.2 1.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EMC88641.1 - 4.3e-24 82.3 5.4 4.3e-09 35.6 0.1 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 EMC88641.1 - 1.1e-19 68.9 11.6 3.3e-08 32.7 0.1 4.0 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EMC88641.1 - 6.4e-19 67.5 12.7 3.5e-12 46.0 0.5 3.6 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 EMC88641.1 - 5.6e-09 36.2 0.1 0.0044 17.3 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain Dockerin_1 PF00404.18 EMC88641.1 - 1.8e-05 24.9 0.5 0.0016 18.6 0.3 2.6 2 1 0 2 2 2 1 Dockerin type I domain SPARC_Ca_bdg PF10591.9 EMC88641.1 - 0.00023 21.5 0.1 0.0055 17.0 0.0 2.1 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EMC88641.1 - 0.01 15.8 2.0 0.062 13.3 0.1 2.5 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_11 PF08976.11 EMC88641.1 - 0.013 16.3 0.0 1.4 9.9 0.0 2.1 1 1 1 2 2 2 0 EF-hand domain POTRA_2 PF08479.11 EMC88641.1 - 0.014 15.2 0.0 0.03 14.2 0.0 1.6 1 0 0 1 1 1 0 POTRA domain, ShlB-type DIMCO_N PF16844.5 EMC88641.1 - 0.034 14.5 0.0 0.058 13.7 0.0 1.4 1 0 0 1 1 1 0 Dinitrogenase iron-molybdenum cofactor, N-terminal Caleosin PF05042.13 EMC88641.1 - 0.046 13.6 0.0 2.3 8.1 0.0 2.4 2 1 0 2 2 2 0 Caleosin related protein TerB PF05099.13 EMC88641.1 - 0.078 12.9 0.2 0.44 10.5 0.0 2.2 2 1 0 2 2 2 0 Tellurite resistance protein TerB zf-RING_2 PF13639.6 EMC88642.1 - 3.1e-07 30.6 9.3 8.9e-07 29.2 9.3 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EMC88642.1 - 5e-07 29.5 8.4 1.5e-06 27.9 8.4 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMC88642.1 - 2.2e-06 27.4 5.9 5.4e-06 26.2 5.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC88642.1 - 2.9e-06 27.1 6.8 9.1e-06 25.5 6.8 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EMC88642.1 - 4.8e-06 26.5 5.7 4.8e-06 26.5 5.7 2.9 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EMC88642.1 - 1.4e-05 24.9 8.6 4.2e-05 23.3 8.6 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC88642.1 - 0.001 18.9 7.7 0.0038 17.1 7.5 2.1 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EMC88642.1 - 0.013 15.6 9.1 0.013 15.6 9.1 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 EMC88642.1 - 0.032 14.3 5.6 0.062 13.4 5.6 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-ACC PF17848.1 EMC88642.1 - 0.043 13.9 0.4 0.15 12.2 0.4 2.0 1 0 0 1 1 1 0 Acetyl-coA carboxylase zinc finger domain zf-rbx1 PF12678.7 EMC88642.1 - 0.18 12.1 10.1 0.41 11.0 10.1 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_6 PF14835.6 EMC88642.1 - 0.36 10.7 6.1 1 9.3 6.0 1.7 1 1 1 2 2 2 0 zf-RING of BARD1-type protein zf-RING_11 PF17123.5 EMC88642.1 - 6.2 6.7 7.9 24 4.8 5.1 3.0 2 0 0 2 2 2 0 RING-like zinc finger Ubie_methyltran PF01209.18 EMC88643.1 - 1e-89 299.9 0.0 1.3e-89 299.5 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EMC88643.1 - 4.7e-17 62.5 0.0 3.2e-15 56.6 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC88643.1 - 5.4e-17 62.2 0.0 1.3e-16 61.0 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC88643.1 - 3.9e-15 55.9 0.0 2.2e-13 50.3 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC88643.1 - 1.1e-08 35.7 0.0 6.2e-08 33.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC88643.1 - 3.3e-05 23.8 0.0 4.8e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EMC88643.1 - 0.0084 16.0 0.0 0.031 14.1 0.0 1.9 2 0 0 2 2 2 1 Hypothetical methyltransferase UPF0020 PF01170.18 EMC88643.1 - 0.016 14.9 0.0 0.026 14.2 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Tmemb_55A PF09788.9 EMC88643.1 - 0.24 10.5 0.0 0.34 9.9 0.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 55A Dynein_light PF01221.18 EMC88644.1 - 2.9e-44 149.3 1.9 3.2e-44 149.1 1.9 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 UCH PF00443.29 EMC88644.1 - 0.1 12.1 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Glu-tRNAGln PF02686.15 EMC88645.1 - 2.4e-12 47.0 0.1 5.7e-12 45.7 0.1 1.6 1 1 1 2 2 2 1 Glu-tRNAGln amidotransferase C subunit COX6A PF02046.15 EMC88646.1 - 3.6e-16 59.6 0.1 7.2e-16 58.7 0.1 1.4 1 1 0 1 1 1 1 Cytochrome c oxidase subunit VIa RRM_1 PF00076.22 EMC88647.1 - 5e-10 39.1 0.5 8.5e-10 38.3 0.5 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMC88647.1 - 0.00023 21.2 0.7 0.00073 19.6 0.7 1.8 1 1 0 1 1 1 1 RNA recognition motif Phospholip_A2_1 PF00068.19 EMC88648.1 - 8e-37 126.1 12.7 9.4e-37 125.9 12.7 1.0 1 0 0 1 1 1 1 Phospholipase A2 Parvo_coat_N PF08398.10 EMC88648.1 - 0.1 12.7 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Parvovirus coat protein VP1 Phospholip_A2_2 PF05826.12 EMC88648.1 - 0.19 11.9 14.2 18 5.7 14.2 2.3 1 1 0 1 1 1 0 Phospholipase A2 SIR2 PF02146.17 EMC88649.1 - 1.2e-50 171.9 0.0 1.7e-50 171.4 0.0 1.2 1 0 0 1 1 1 1 Sir2 family XPA_N PF01286.18 EMC88649.1 - 0.54 10.4 2.6 15 5.8 0.3 2.4 2 0 0 2 2 2 0 XPA protein N-terminal Paxillin PF03535.13 EMC88650.1 - 2e-92 308.6 23.3 3.6e-92 307.8 23.3 1.4 1 0 0 1 1 1 1 Paxillin family LIM PF00412.22 EMC88650.1 - 1.9e-67 223.4 37.2 3.5e-18 65.6 2.1 4.4 4 0 0 4 4 4 4 LIM domain DUF1797 PF08796.10 EMC88650.1 - 0.23 11.6 0.2 8.3 6.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1797) Ribosomal_L37e PF01907.19 EMC88650.1 - 0.75 10.0 8.6 19 5.5 0.1 4.1 3 0 0 3 3 3 0 Ribosomal protein L37e Ion_trans PF00520.31 EMC88651.1 - 3.3e-29 101.8 7.5 6e-29 101.0 7.5 1.4 1 0 0 1 1 1 1 Ion transport protein CLZ PF16526.5 EMC88651.1 - 1.9e-26 92.2 6.5 5.8e-26 90.7 6.5 1.9 1 0 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels cNMP_binding PF00027.29 EMC88651.1 - 1.4e-18 66.7 0.0 2.6e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 EMC88651.1 - 0.047 13.7 6.7 0.16 12.0 6.7 2.0 1 1 0 1 1 1 0 Ion channel Miff PF05644.11 EMC88652.1 - 8e-17 61.8 0.1 9.1e-17 61.6 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial and peroxisomal fission factor Mff Nsp1_C PF05064.13 EMC88654.1 - 1.9e-40 137.3 5.2 1.9e-40 137.3 5.2 1.8 2 0 0 2 2 2 1 Nsp1-like C-terminal region DUF4164 PF13747.6 EMC88654.1 - 0.0068 16.6 1.5 0.0068 16.6 1.5 2.7 2 1 1 3 3 3 1 Domain of unknown function (DUF4164) Nup188_C PF18378.1 EMC88654.1 - 0.021 13.7 2.4 0.036 12.9 2.4 1.4 1 0 0 1 1 1 0 Nuclear pore protein NUP188 C-terminal domain GAS PF13851.6 EMC88654.1 - 0.16 11.3 14.6 0.49 9.7 14.6 1.8 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Cauli_DNA-bind PF03310.13 EMC88654.1 - 0.72 9.9 3.8 5.9 7.0 0.2 2.3 2 0 0 2 2 2 0 Caulimovirus DNA-binding protein YscO-like PF16789.5 EMC88654.1 - 0.83 9.7 13.2 0.56 10.2 3.2 2.2 2 0 0 2 2 2 0 YscO-like protein DUF16 PF01519.16 EMC88654.1 - 4.1 7.9 14.3 0.6 10.6 3.5 2.9 1 1 1 2 2 2 0 Protein of unknown function DUF16 Nucleoporin_FG2 PF15967.5 EMC88654.1 - 9 4.7 39.5 10 4.5 0.3 2.0 2 0 0 2 2 2 0 Nucleoporin FG repeated region DUF1664 PF07889.12 EMC88654.1 - 9.9 6.2 12.1 4.8 7.2 2.8 2.8 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) Nsp1_C PF05064.13 EMC88655.1 - 1.8e-40 137.4 5.2 1.8e-40 137.4 5.2 1.9 2 0 0 2 2 2 1 Nsp1-like C-terminal region DUF4164 PF13747.6 EMC88655.1 - 0.0065 16.7 1.6 0.0065 16.7 1.6 2.8 1 1 2 3 3 3 1 Domain of unknown function (DUF4164) Nup188_C PF18378.1 EMC88655.1 - 0.027 13.3 2.6 0.044 12.6 2.6 1.3 1 0 0 1 1 1 0 Nuclear pore protein NUP188 C-terminal domain GAS PF13851.6 EMC88655.1 - 0.089 12.1 14.9 0.19 11.0 14.8 1.6 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Laminin_II PF06009.12 EMC88655.1 - 1.3 9.1 9.2 1.7 8.6 1.2 2.4 1 1 1 2 2 2 0 Laminin Domain II TBCC_N PF16752.5 EMC88655.1 - 1.4 9.4 8.2 0.3 11.6 0.4 2.6 1 1 1 2 2 2 0 Tubulin-specific chaperone C N-terminal domain SKA2 PF16740.5 EMC88655.1 - 2.4 8.0 8.8 1.3 8.8 1.1 2.6 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 Cob_adeno_trans PF01923.18 EMC88655.1 - 3.2 7.9 6.1 6.7 6.8 0.5 2.7 1 1 1 2 2 2 0 Cobalamin adenosyltransferase DUF1664 PF07889.12 EMC88655.1 - 4.6 7.3 12.1 3.7 7.6 2.4 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) FapA PF03961.13 EMC88655.1 - 5.3 5.5 7.8 7.4 5.0 6.2 1.7 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF16 PF01519.16 EMC88655.1 - 5.4 7.5 14.9 0.58 10.7 3.6 2.9 1 1 2 3 3 3 0 Protein of unknown function DUF16 Nucleoporin_FG2 PF15967.5 EMC88655.1 - 5.9 5.3 41.0 6.3 5.2 0.4 2.1 2 0 0 2 2 2 0 Nucleoporin FG repeated region DUF745 PF05335.13 EMC88655.1 - 6.3 6.5 6.9 7.9 6.2 0.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF745) XhlA PF10779.9 EMC88655.1 - 6.6 7.0 10.0 57 4.0 1.0 3.4 2 1 1 3 3 3 0 Haemolysin XhlA NPV_P10 PF05531.12 EMC88655.1 - 6.9 7.2 10.1 30 5.2 0.2 3.3 1 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Clat_adaptor_s PF01217.20 EMC88657.1 - 2.5e-54 183.1 1.3 2.8e-54 182.9 1.3 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain ATX_III PF08098.11 EMC88658.1 - 1 9.5 10.3 26 5.0 0.2 4.0 3 0 0 3 3 3 0 Anemonia sulcata toxin III family ATP-synt_ab PF00006.25 EMC88660.1 - 2.2e-93 311.8 0.0 3.6e-93 311.1 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 EMC88660.1 - 5.7e-29 100.4 0.0 1e-28 99.6 0.0 1.3 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 EMC88660.1 - 3.1e-09 37.2 0.5 3.1e-09 37.2 0.5 2.1 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain C2 PF00168.30 EMC88663.1 - 1.8e-11 44.2 0.0 2.6e-11 43.7 0.0 1.1 1 0 0 1 1 1 1 C2 domain 7tm_4 PF13853.6 EMC88664.1 - 1.8e-48 165.7 7.5 2.3e-48 165.3 7.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC88664.1 - 3.2e-29 102.1 10.1 4.4e-29 101.6 10.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC88664.1 - 0.0083 15.8 10.9 0.041 13.5 10.9 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx bZIP_1 PF00170.21 EMC88666.1 - 5e-13 48.9 8.5 8.3e-13 48.2 8.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMC88666.1 - 1.3e-10 41.2 7.9 2.2e-10 40.5 7.9 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EMC88666.1 - 1.8e-05 25.2 4.3 4.7e-05 23.8 4.3 1.7 1 0 0 1 1 1 1 bZIP Maf transcription factor ZapB PF06005.12 EMC88666.1 - 0.002 18.5 2.3 0.0044 17.4 2.3 1.5 1 0 0 1 1 1 1 Cell division protein ZapB TolA_bind_tri PF16331.5 EMC88666.1 - 0.015 15.4 3.1 0.015 15.4 3.1 2.5 3 0 0 3 3 3 0 TolA binding protein trimerisation NDUFB11 PF17250.2 EMC88666.1 - 0.043 14.5 1.8 0.048 14.3 0.4 1.7 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase 11 kDa subunit Cnn_1N PF07989.11 EMC88666.1 - 0.077 13.2 2.5 0.16 12.2 2.5 1.5 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 GIT_CC PF16559.5 EMC88666.1 - 0.11 12.4 5.0 0.31 11.0 5.0 1.8 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor DivIC PF04977.15 EMC88666.1 - 0.35 10.7 3.1 0.61 9.9 3.1 1.3 1 0 0 1 1 1 0 Septum formation initiator LRR_8 PF13855.6 EMC88667.1 - 1.2e-61 204.3 44.5 1.1e-17 63.6 2.5 5.2 2 2 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EMC88667.1 - 9e-21 73.6 28.5 0.0034 17.7 0.1 7.3 3 3 4 8 8 8 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC88667.1 - 8.8e-17 59.1 31.9 0.14 12.8 0.0 11.5 11 1 1 12 12 12 6 Leucine Rich Repeat LRR_9 PF14580.6 EMC88667.1 - 7.2e-15 54.9 0.6 2.6e-05 23.8 0.0 4.1 1 1 2 4 4 4 4 Leucine-rich repeat LRR_5 PF13306.6 EMC88667.1 - 8.9e-10 38.6 0.0 0.00027 20.9 0.0 3.1 1 1 1 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 EMC88667.1 - 0.0012 18.7 30.6 4.3 7.6 0.1 9.7 11 0 0 11 11 11 3 Leucine Rich repeat LRRNT PF01462.18 EMC88667.1 - 0.047 13.3 1.6 0.096 12.4 1.6 1.5 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain WH2 PF02205.20 EMC88668.1 - 1.4e-09 37.5 0.8 1.4e-09 37.5 0.8 2.1 2 0 0 2 2 2 1 WH2 motif Peptidase_C69 PF03577.15 EMC88670.1 - 9.8e-09 34.6 0.0 1.5e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C69 AAT PF03417.16 EMC88670.1 - 0.063 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase GLTP PF08718.11 EMC88671.1 - 1.8e-34 119.2 0.1 8.7e-34 116.9 0.0 2.2 2 0 0 2 2 2 1 Glycolipid transfer protein (GLTP) PH PF00169.29 EMC88671.1 - 1.1e-08 35.5 0.0 4.6e-08 33.5 0.0 2.1 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 EMC88671.1 - 3.1e-05 24.2 0.0 0.00012 22.3 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 EMC88671.1 - 0.018 15.4 0.1 0.25 11.8 0.1 2.6 1 1 0 1 1 1 0 Pleckstrin homology domain IFT20 PF14931.6 EMC88671.1 - 1.2 9.3 4.9 31 4.8 0.8 3.2 2 1 1 3 3 3 0 Intraflagellar transport complex B, subunit 20 Collagen PF01391.18 EMC88672.1 - 1.3e-29 101.7 100.7 9.6e-10 38.1 28.6 4.6 1 1 2 3 3 3 2 Collagen triple helix repeat (20 copies) DUF4215 PF13948.6 EMC88672.1 - 6.7e-05 23.2 5.0 6.7e-05 23.2 5.0 3.0 1 1 2 3 3 3 2 Domain of unknown function (DUF4215) CN_hydrolase PF00795.22 EMC88673.1 - 6.7e-16 58.4 0.0 1e-15 57.8 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Ank_2 PF12796.7 EMC88674.1 - 2.5e-164 534.3 68.2 7.4e-18 64.9 0.2 14.0 3 3 14 17 17 17 17 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC88674.1 - 1.7e-152 494.0 48.6 8.6e-15 54.9 0.8 20.8 7 4 16 23 23 23 23 Ankyrin repeats (many copies) Ank PF00023.30 EMC88674.1 - 4.8e-143 460.0 75.4 4.3e-07 30.1 0.1 27.9 28 0 0 28 28 28 26 Ankyrin repeat Ank_5 PF13857.6 EMC88674.1 - 1.6e-118 385.2 57.9 9.9e-10 38.5 0.1 21.5 5 4 19 24 24 24 22 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC88674.1 - 2.1e-118 371.7 51.3 1.6e-05 24.9 0.1 28.1 28 0 0 28 28 28 27 Ankyrin repeat Glycos_transf_2 PF00535.26 EMC88675.1 - 1.1e-29 103.5 0.0 1.8e-29 102.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 EMC88675.1 - 3.9e-20 72.4 0.3 6.9e-20 71.6 0.3 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 EMC88675.1 - 6.2e-06 26.3 0.0 1.5e-05 25.0 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 EMC88675.1 - 0.00012 21.6 0.0 0.00028 20.5 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase RicinB_lectin_2 PF14200.6 EMC88675.1 - 0.00022 21.9 0.0 0.006 17.3 0.1 2.6 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain-like Glyco_tranf_2_2 PF10111.9 EMC88675.1 - 0.00061 19.3 0.0 0.0033 16.9 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase like family 2 zf-CSL PF05207.13 EMC88676.1 - 3.1e-24 84.5 2.0 4.1e-24 84.1 2.0 1.2 1 0 0 1 1 1 1 CSL zinc finger zf-RING_7 PF02591.15 EMC88676.1 - 0.029 14.6 0.3 0.087 13.0 0.1 1.9 2 0 0 2 2 2 0 C4-type zinc ribbon domain NAD_binding_1 PF00175.21 EMC88677.1 - 2.1e-13 50.9 0.0 5e-13 49.7 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EMC88677.1 - 2.2e-06 27.9 0.0 4.8e-05 23.5 0.0 2.3 1 1 1 2 2 2 1 Ferric reductase NAD binding domain DUF1707 PF08044.11 EMC88677.1 - 0.029 14.5 0.0 0.059 13.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1707) Raftlin PF15250.6 EMC88678.1 - 7.1e-220 730.6 0.8 9.3e-220 730.2 0.8 1.1 1 0 0 1 1 1 1 Raftlin PilO PF04350.13 EMC88678.1 - 0.052 13.7 0.1 0.052 13.7 0.1 2.0 2 0 0 2 2 2 0 Pilus assembly protein, PilO TLP-20 PF06088.11 EMC88678.1 - 0.27 11.1 5.7 0.052 13.4 1.6 1.8 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) RRM_1 PF00076.22 EMC88679.1 - 2.9e-14 52.6 0.3 4.6e-14 52.0 0.3 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMC88679.1 - 0.00093 19.3 0.6 0.0045 17.1 0.1 2.3 2 1 0 2 2 2 1 RNA recognition motif RRM_5 PF13893.6 EMC88679.1 - 0.0065 16.1 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PI-PLC-X PF00388.19 EMC88680.1 - 1.8e-61 206.0 0.1 3.9e-61 204.9 0.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EMC88680.1 - 5.3e-39 133.1 0.2 1.5e-38 131.7 0.2 1.9 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain PH_12 PF16457.5 EMC88680.1 - 1e-21 77.8 0.3 4.5e-21 75.8 0.1 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain EF-hand_like PF09279.11 EMC88680.1 - 3e-17 62.9 0.0 7e-17 61.7 0.0 1.7 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.30 EMC88680.1 - 1.1e-16 61.0 0.0 2.6e-16 59.8 0.0 1.6 1 0 0 1 1 1 1 C2 domain PH_14 PF17787.1 EMC88680.1 - 1.6e-06 28.0 0.1 4.3e-06 26.6 0.1 1.7 1 0 0 1 1 1 1 PH domain PH PF00169.29 EMC88680.1 - 1e-05 26.0 0.1 3.4e-05 24.3 0.1 2.0 1 0 0 1 1 1 1 PH domain Mcp5_PH PF12814.7 EMC88680.1 - 0.00076 19.6 0.0 0.0019 18.3 0.0 1.7 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology CUTL PF16557.5 EMC88681.1 - 4.3e-43 145.3 2.8 1.8e-42 143.4 0.5 3.1 3 0 0 3 3 3 1 CUT1-like DNA-binding domain of SATB CUT PF02376.15 EMC88681.1 - 3e-39 133.0 3.4 1.1e-23 83.1 0.1 3.2 3 0 0 3 3 3 2 CUT domain ULD PF16534.5 EMC88681.1 - 3.2e-37 126.9 0.0 1.2e-36 125.1 0.0 2.0 1 0 0 1 1 1 1 Ubiquitin-like oligomerisation domain of SATB Homeodomain PF00046.29 EMC88681.1 - 4.3e-07 29.7 0.0 1.2e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 Homeodomain SUIM_assoc PF16619.5 EMC88681.1 - 0.0015 18.6 3.4 0.0015 18.6 3.4 2.4 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 HTH_3 PF01381.22 EMC88681.1 - 0.045 13.8 0.0 0.47 10.5 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix RuvA_C PF07499.13 EMC88681.1 - 0.088 13.3 0.1 0.69 10.4 0.1 2.5 2 0 0 2 2 2 0 RuvA, C-terminal domain Ion_trans PF00520.31 EMC88682.1 - 7.2e-33 113.8 13.2 1.1e-32 113.3 13.2 1.2 1 0 0 1 1 1 1 Ion transport protein PAS_9 PF13426.7 EMC88682.1 - 1.7e-18 66.7 0.0 6.7e-18 64.9 0.0 2.0 2 0 0 2 2 2 1 PAS domain Ion_trans_2 PF07885.16 EMC88682.1 - 8.8e-11 41.6 0.6 8.8e-11 41.6 0.6 2.9 3 0 0 3 3 3 1 Ion channel cNMP_binding PF00027.29 EMC88682.1 - 1.1e-09 38.2 0.0 2.7e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain PAS_3 PF08447.12 EMC88682.1 - 1.5e-07 31.6 0.0 3e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EMC88682.1 - 0.00019 21.6 0.0 0.0011 19.2 0.0 2.1 2 0 0 2 2 2 1 PAS fold PAS PF00989.25 EMC88682.1 - 0.00024 21.1 0.0 0.00069 19.6 0.0 1.8 1 0 0 1 1 1 1 PAS fold Dynamitin PF04912.14 EMC88682.1 - 0.0024 17.3 0.0 0.0044 16.4 0.0 1.5 1 0 0 1 1 1 1 Dynamitin CENP-F_leu_zip PF10473.9 EMC88682.1 - 0.0027 17.7 1.8 1.2 9.2 1.7 2.6 2 0 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SlyX PF04102.12 EMC88682.1 - 0.074 13.7 0.6 0.24 12.0 0.6 1.8 1 0 0 1 1 1 0 SlyX LPP PF04728.13 EMC88682.1 - 0.081 13.3 0.9 0.23 11.9 0.9 1.8 1 0 0 1 1 1 0 Lipoprotein leucine-zipper DUF1664 PF07889.12 EMC88682.1 - 0.15 12.1 1.1 0.35 10.9 1.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) ZapB PF06005.12 EMC88682.1 - 0.26 11.8 3.1 0.93 10.0 3.1 1.9 1 0 0 1 1 1 0 Cell division protein ZapB NPV_P10 PF05531.12 EMC88682.1 - 0.29 11.6 1.5 0.86 10.1 1.5 1.8 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein G_path_suppress PF15991.5 EMC88682.1 - 1.1 9.4 8.2 3.8 7.6 8.2 1.9 1 1 0 1 1 1 0 G-protein pathway suppressor Baculo_PEP_C PF04513.12 EMC88682.1 - 2.1 8.4 6.2 0.43 10.6 1.6 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus EF-hand_1 PF00036.32 EMC88683.1 - 2e-11 42.6 3.9 6.3e-06 25.4 0.2 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EMC88683.1 - 2.4e-11 43.9 5.8 4.9e-11 42.9 5.8 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EMC88683.1 - 1.2e-10 40.5 5.1 1e-05 25.0 0.2 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EMC88683.1 - 2.7e-08 32.9 2.0 0.0002 20.7 0.1 2.7 2 0 0 2 2 2 2 EF hand DUF5580 PF17743.1 EMC88683.1 - 2e-05 23.4 0.2 3.1e-05 22.7 0.2 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5580) EF-hand_8 PF13833.6 EMC88683.1 - 4.1e-05 23.3 5.9 0.00016 21.4 4.5 2.4 1 1 1 2 2 2 2 EF-hand domain pair DUF4483 PF14825.6 EMC88683.1 - 0.00042 20.1 0.0 0.07 12.9 0.0 3.1 2 1 0 3 3 3 1 Domain of unknown function (DUF4483) SPARC_Ca_bdg PF10591.9 EMC88683.1 - 0.00095 19.5 0.4 0.0023 18.2 0.4 1.6 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 EMC88683.1 - 0.69 9.8 6.1 0.4 10.6 1.5 2.8 2 1 1 3 3 3 0 EF hand Ras PF00071.22 EMC88684.1 - 3.1e-63 212.2 0.3 3.6e-63 212.0 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC88684.1 - 7.5e-36 123.0 0.1 1.5e-35 122.0 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC88684.1 - 1e-12 47.9 0.0 1.2e-12 47.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EMC88684.1 - 2.2e-05 24.0 0.0 2.9e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMC88684.1 - 5.4e-05 23.2 0.0 8.8e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC88684.1 - 0.0004 20.3 0.3 0.36 10.7 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EMC88684.1 - 0.0018 17.9 0.0 0.0052 16.4 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EMC88684.1 - 0.013 15.9 0.1 0.022 15.2 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain MCR_beta PF02241.18 EMC88684.1 - 0.021 14.4 0.3 0.027 14.1 0.3 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, C-terminal domain BrnT_toxin PF04365.13 EMC88684.1 - 0.063 13.6 0.1 0.48 10.8 0.0 2.1 2 0 0 2 2 2 0 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system PP2C PF00481.21 EMC88685.1 - 2.3e-30 106.1 0.2 7.4e-24 84.8 0.0 3.5 3 1 1 4 4 4 2 Protein phosphatase 2C PCAF_N PF06466.11 EMC88686.1 - 1.7e-94 316.1 0.0 2.8e-94 315.4 0.0 1.4 1 0 0 1 1 1 1 PCAF (P300/CBP-associated factor) N-terminal domain Bromodomain PF00439.25 EMC88686.1 - 3.6e-25 87.8 0.4 8.5e-25 86.6 0.4 1.7 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 EMC88686.1 - 3.8e-10 40.0 0.0 8.6e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMC88686.1 - 1.6e-07 31.3 0.0 3.3e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMC88686.1 - 6.7e-06 26.5 0.2 1.4e-05 25.4 0.2 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EMC88686.1 - 0.11 12.6 0.1 0.3 11.2 0.1 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-met PF12874.7 EMC88687.1 - 3.2e-21 75.0 16.9 3.2e-08 33.7 2.4 3.6 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMC88687.1 - 9.4e-18 64.0 14.2 1.6e-06 28.2 3.2 3.3 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EMC88687.1 - 1e-07 32.2 6.7 0.016 15.5 0.1 3.2 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.12 EMC88687.1 - 1.3e-06 28.7 8.1 0.15 12.3 0.6 3.2 3 0 0 3 3 3 3 A-kinase anchoring protein 95 (AKAP95) zf-U1 PF06220.12 EMC88687.1 - 1.3e-06 28.0 6.6 0.06 13.1 0.0 3.3 3 0 0 3 3 3 2 U1 zinc finger zf-C2H2_4 PF13894.6 EMC88687.1 - 0.0032 18.2 5.3 1.4 10.0 0.6 3.5 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC88687.1 - 0.0062 16.9 11.0 2 9.0 2.0 3.6 3 0 0 3 3 3 1 Zinc finger, C2H2 type OrfB_Zn_ribbon PF07282.11 EMC88687.1 - 0.0094 15.9 5.6 0.2 11.6 0.8 3.4 3 0 0 3 3 3 1 Putative transposase DNA-binding domain zf_C2H2_ZHX PF18387.1 EMC88687.1 - 0.011 15.4 4.1 1.2 8.9 0.3 2.5 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_9 PF16293.5 EMC88687.1 - 0.03 14.2 5.3 4.3 7.3 0.3 3.4 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) DUF3449 PF11931.8 EMC88687.1 - 0.033 14.0 8.2 0.26 11.1 1.2 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF3449) zf-Sec23_Sec24 PF04810.15 EMC88687.1 - 0.037 14.1 3.4 16 5.7 0.1 3.4 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger zf-DBF PF07535.12 EMC88687.1 - 0.057 13.5 8.5 0.086 13.0 0.9 3.3 3 0 0 3 3 3 0 DBF zinc finger UPF0728 PF15092.6 EMC88687.1 - 0.059 13.2 0.1 1.3 8.9 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0728 DUF4187 PF13821.6 EMC88687.1 - 0.084 12.7 0.0 2.4 8.0 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4187) zinc_ribbon_15 PF17032.5 EMC88687.1 - 0.51 11.1 6.3 17 6.2 0.1 3.0 2 1 2 4 4 4 0 zinc-ribbon family DUF493 PF04359.14 EMC88687.1 - 5.7 7.6 6.0 7.9 7.1 0.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF493) PHD_2 PF13831.6 EMC88687.1 - 7.9 6.1 6.9 9 5.9 0.2 3.0 3 0 0 3 3 3 0 PHD-finger zf-BED PF02892.15 EMC88687.1 - 8 6.6 8.4 5.7 7.0 0.1 2.8 3 0 0 3 3 3 0 BED zinc finger zf-met PF12874.7 EMC88688.1 - 1.7e-08 34.6 0.7 3.8e-08 33.4 0.7 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMC88688.1 - 0.00028 21.1 0.7 0.00028 21.1 0.7 1.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding Tox-GHH PF15636.6 EMC88689.1 - 2.2e-29 101.3 0.9 4.4e-29 100.3 0.9 1.5 1 0 0 1 1 1 1 GHH signature containing HNH/Endo VII superfamily nuclease toxin Ten_N PF06484.12 EMC88689.1 - 2.8e-23 83.4 8.7 4.1e-23 82.9 8.7 1.3 1 0 0 1 1 1 1 Teneurin Intracellular Region EGF_2 PF07974.13 EMC88689.1 - 2e-20 72.8 148.5 0.00042 20.6 13.3 9.7 8 1 1 9 9 9 7 EGF-like domain RHS_repeat PF05593.14 EMC88689.1 - 5.2e-13 49.2 29.3 0.00046 20.6 0.8 8.6 8 1 1 9 9 9 5 RHS Repeat NHL PF01436.21 EMC88689.1 - 4e-07 29.8 1.1 0.13 12.4 0.0 5.9 5 0 0 5 5 5 1 NHL repeat SGL PF08450.12 EMC88689.1 - 0.00028 20.6 0.1 0.33 10.5 0.0 3.9 3 1 0 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region CarboxypepD_reg PF13620.6 EMC88689.1 - 0.0082 16.4 0.1 0.027 14.7 0.1 1.9 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain DUF1939 PF09154.10 EMC88689.1 - 0.061 13.5 0.2 0.21 11.8 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1939) RHS PF03527.14 EMC88689.1 - 0.1 12.4 1.8 0.21 11.3 0.0 2.5 3 0 0 3 3 3 0 RHS protein SH2 PF00017.24 EMC88690.1 - 2.6e-14 53.1 0.0 3.5e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 SH2 domain STAG PF08514.11 EMC88692.1 - 1.8e-37 127.7 0.2 6.8e-37 125.8 0.2 2.1 1 0 0 1 1 1 1 STAG domain Cnd3 PF12719.7 EMC88692.1 - 0.018 14.2 0.4 0.018 14.2 0.4 2.3 3 0 0 3 3 3 0 Nuclear condensing complex subunits, C-term domain AdoHcyase_NAD PF00670.21 EMC88692.1 - 0.032 14.3 0.0 0.071 13.2 0.0 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain BIR PF00653.21 EMC88693.1 - 2.7e-61 204.1 16.2 5.7e-23 81.4 0.7 3.8 4 0 0 4 4 4 3 Inhibitor of Apoptosis domain zf-C3HC4_3 PF13920.6 EMC88693.1 - 2.8e-13 49.5 9.7 2.8e-13 49.5 9.7 4.0 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC88693.1 - 8.5e-09 35.1 12.0 2.9e-08 33.4 8.5 2.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC PF07967.13 EMC88693.1 - 4.2e-07 30.1 1.9 0.32 11.0 0.0 3.7 3 0 0 3 3 3 3 C3HC zinc finger-like zf-RING_2 PF13639.6 EMC88693.1 - 0.00058 20.2 8.5 0.00058 20.2 8.5 3.4 4 0 0 4 4 4 1 Ring finger domain zf-RING_5 PF14634.6 EMC88693.1 - 0.0091 15.9 7.3 0.0091 15.9 7.3 3.5 4 0 0 4 4 4 1 zinc-RING finger domain RNA_pol_N PF01194.17 EMC88693.1 - 1.7 9.0 7.7 51 4.3 0.1 3.7 3 0 0 3 3 3 0 RNA polymerases N / 8 kDa subunit Tho2 PF11262.8 EMC88694.1 - 3.6e-104 348.2 2.3 3.6e-104 348.2 2.3 4.5 4 2 1 5 5 5 1 Transcription factor/nuclear export subunit protein 2 THOC2_N PF16134.5 EMC88694.1 - 1e-81 275.5 4.3 1.2e-55 189.3 1.6 5.0 3 2 1 4 4 4 2 THO complex subunit 2 N-terminus Thoc2 PF11732.8 EMC88694.1 - 3.5e-37 126.3 0.9 3e-36 123.3 0.2 2.8 3 0 0 3 3 3 1 Transcription- and export-related complex subunit Lig_chan PF00060.26 EMC88695.1 - 9.4e-60 200.8 0.0 1.6e-59 200.0 0.0 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel ANF_receptor PF01094.28 EMC88695.1 - 7.2e-53 179.9 0.3 1e-52 179.4 0.3 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan-Glu_bd PF10613.9 EMC88695.1 - 1.1e-45 154.5 0.0 2.2e-45 153.6 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 EMC88695.1 - 3.6e-24 85.5 0.0 6.6e-24 84.6 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 DUF2061 PF09834.9 EMC88695.1 - 0.076 13.5 0.2 0.26 11.8 0.2 2.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2061) NusG_add PF18298.1 EMC88695.1 - 0.079 13.2 0.1 0.16 12.2 0.1 1.5 1 0 0 1 1 1 0 NusG additional domain TLV_coat PF00429.19 EMC88696.1 - 4.6e-08 32.2 1.9 5.4e-08 32.0 1.9 1.0 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) Pre-PUA PF17832.1 EMC88698.1 - 9.7e-26 90.3 0.1 1.4e-25 89.7 0.1 1.3 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 EMC88698.1 - 3.6e-21 74.9 0.1 6.2e-21 74.1 0.1 1.4 1 0 0 1 1 1 1 PUA domain Methyltr_RsmF_N PF17125.5 EMC88698.1 - 0.054 14.0 0.0 0.082 13.4 0.0 1.3 1 0 0 1 1 1 0 N-terminal domain of 16S rRNA methyltransferase RsmF DUF1947 PF09183.10 EMC88698.1 - 0.072 13.4 0.0 0.14 12.5 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1947) Cullin PF00888.22 EMC88699.1 - 5.1e-212 705.8 18.7 8.1e-212 705.2 18.7 1.3 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EMC88699.1 - 1.4e-25 89.1 1.6 5.6e-25 87.2 1.6 2.2 1 0 0 1 1 1 1 Cullin protein neddylation domain SecA_SW PF07516.13 EMC88699.1 - 3.6e-05 23.9 0.6 3.6e-05 23.9 0.6 3.2 3 1 0 3 3 3 1 SecA Wing and Scaffold domain PG_binding_4 PF12229.8 EMC88699.1 - 0.3 11.4 2.1 2.1 8.6 0.1 3.2 3 0 0 3 3 3 0 Putative peptidoglycan binding domain Lamp PF01299.17 EMC88700.1 - 7.9e-49 165.3 11.5 2.1e-42 144.5 2.6 2.3 2 0 0 2 2 2 2 Lysosome-associated membrane glycoprotein (Lamp) ATP-synt_S1 PF05827.12 EMC88700.1 - 2.2e-06 27.6 3.0 3.9e-06 26.8 1.3 2.0 2 0 0 2 2 2 1 Vacuolar ATP synthase subunit S1 (ATP6S1) FAM70 PF14967.6 EMC88701.1 - 2.1e-156 520.5 4.5 2.4e-156 520.3 4.5 1.0 1 0 0 1 1 1 1 FAM70 protein DUF4064 PF13273.6 EMC88701.1 - 0.00021 21.5 10.5 0.028 14.7 8.4 2.7 2 1 0 2 2 2 2 Protein of unknown function (DUF4064) Phage_holin_3_2 PF04550.12 EMC88701.1 - 0.062 13.8 1.0 0.062 13.8 1.0 1.9 2 0 0 2 2 2 0 Phage holin family 2 Connexin PF00029.19 EMC88703.1 - 8.2e-86 287.6 0.1 1.1e-85 287.1 0.1 1.1 1 0 0 1 1 1 1 Connexin Homeodomain PF00046.29 EMC88704.1 - 2.3e-25 88.2 3.8 2.5e-25 88.1 3.8 1.0 1 0 0 1 1 1 1 Homeodomain SatD PF16264.5 EMC88704.1 - 0.032 13.8 0.0 0.036 13.7 0.0 1.1 1 0 0 1 1 1 0 SatD family (SatD) Homeobox_KN PF05920.11 EMC88704.1 - 0.039 13.8 0.4 0.12 12.3 0.4 1.8 1 1 0 1 1 1 0 Homeobox KN domain Peptidase_M14 PF00246.24 EMC88708.1 - 7.2e-59 200.0 0.0 4.7e-58 197.3 0.0 2.0 1 1 0 1 1 1 1 Zinc carboxypeptidase F5_F8_type_C PF00754.25 EMC88708.1 - 2.1e-22 79.6 0.1 3.9e-22 78.7 0.1 1.5 1 0 0 1 1 1 1 F5/8 type C domain CarboxypepD_reg PF13620.6 EMC88708.1 - 6.2e-15 55.2 0.1 1.1e-14 54.5 0.1 1.4 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 EMC88708.1 - 8.6e-07 28.9 0.2 3.2e-06 27.0 0.0 2.0 2 0 0 2 2 2 1 CarboxypepD_reg-like domain Gelsolin PF00626.22 EMC88709.1 - 4.8e-13 48.8 0.0 2.7e-06 27.2 0.0 2.1 2 0 0 2 2 2 2 Gelsolin repeat SH3_9 PF14604.6 EMC88710.1 - 4.8e-13 48.7 0.5 1.3e-12 47.4 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EMC88710.1 - 8.1e-13 47.8 0.2 8.1e-13 47.8 0.2 2.8 4 0 0 4 4 4 1 SH3 domain SH3_2 PF07653.17 EMC88710.1 - 1.2e-06 28.1 0.0 2.3e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain NPR3 PF03666.13 EMC88710.1 - 7.3 5.3 9.6 9.2 4.9 9.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Mac_assoc PF16628.5 EMC88711.1 - 0.049 13.8 0.1 5.9 7.1 0.0 2.1 2 0 0 2 2 2 0 Unstructured region on maltose acetyltransferase DUF899 PF05988.12 EMC88711.1 - 0.38 10.2 7.0 0.66 9.5 0.1 3.2 1 1 3 4 4 4 0 Bacterial protein of unknown function (DUF899) HMG_box PF00505.19 EMC88712.1 - 7.6e-22 77.5 1.2 1.4e-21 76.6 1.2 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box CTNNB1_binding PF08347.11 EMC88712.1 - 9.9e-20 71.6 0.7 9.9e-20 71.6 0.7 2.8 2 1 0 2 2 2 1 N-terminal CTNNB1 binding HMG_box_2 PF09011.10 EMC88712.1 - 5.8e-09 36.4 1.7 9.7e-09 35.7 1.7 1.4 1 0 0 1 1 1 1 HMG-box domain Homeodomain PF00046.29 EMC88717.1 - 2.9e-24 84.7 7.4 3.1e-24 84.6 7.4 1.0 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC88717.1 - 3.9e-05 23.4 1.6 5.5e-05 23.0 0.6 1.7 1 1 1 2 2 2 1 Homeobox KN domain CENP-B_N PF04218.13 EMC88717.1 - 0.00038 20.0 0.7 0.00075 19.1 0.7 1.7 1 1 0 1 1 1 1 CENP-B N-terminal DNA-binding domain DUF2316 PF10078.9 EMC88717.1 - 0.0047 17.1 0.8 0.0047 17.1 0.8 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2316) HTH_26 PF13443.6 EMC88717.1 - 0.031 14.7 0.1 0.34 11.4 0.0 2.0 1 1 1 2 2 2 0 Cro/C1-type HTH DNA-binding domain YdaS_antitoxin PF15943.5 EMC88717.1 - 0.1 12.5 0.1 0.13 12.2 0.1 1.2 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT QLQ PF08880.11 EMC88717.1 - 0.12 12.2 2.6 0.1 12.4 1.5 1.7 2 1 0 2 2 2 0 QLQ PPDFL PF15060.6 EMC88718.1 - 1.9e-05 25.2 0.1 2.3e-05 24.9 0.1 1.1 1 0 0 1 1 1 1 Differentiation and proliferation regulator Ig_3 PF13927.6 EMC88721.1 - 5.2e-10 39.8 0.1 1.2e-09 38.7 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC88721.1 - 1.2e-09 38.1 0.0 2.1e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 EMC88721.1 - 4.5e-09 36.4 0.1 9e-09 35.4 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC88721.1 - 9.2e-07 29.1 0.1 2e-06 28.0 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC88721.1 - 5.5e-06 26.5 3.3 0.18 12.0 0.1 3.2 2 1 1 3 3 3 2 Immunoglobulin V-set domain Ig_6 PF18452.1 EMC88721.1 - 0.0004 19.9 0.0 0.00079 19.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_5 PF16681.5 EMC88721.1 - 0.0027 18.1 0.5 0.014 15.8 0.1 2.1 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Receptor_2B4 PF11465.8 EMC88721.1 - 0.01 16.0 0.3 4.4 7.6 0.0 2.7 3 0 0 3 3 3 0 Natural killer cell receptor 2B4 I-set PF07679.16 EMC88722.1 - 5.4e-12 45.6 0.0 1.8e-08 34.4 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC88722.1 - 4.9e-10 39.9 0.3 4.8e-08 33.5 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 EMC88722.1 - 7.5e-09 35.7 0.0 0.0012 19.0 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_2 PF13895.6 EMC88722.1 - 2e-08 34.4 0.2 2.6e-05 24.5 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 EMC88722.1 - 5.1e-05 23.4 0.3 0.019 15.1 0.1 2.6 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC88724.1 - 1.3e-12 47.6 0.0 2.3e-08 34.0 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC88724.1 - 2.1e-11 44.3 0.1 7.3e-07 29.7 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 EMC88724.1 - 6e-09 36.0 0.0 8.7e-06 25.9 0.0 2.4 2 1 0 2 2 2 2 Immunoglobulin V-set domain Ig_2 PF13895.6 EMC88724.1 - 4.2e-07 30.2 0.1 1.3e-05 25.4 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 EMC88724.1 - 0.00042 20.4 0.1 0.51 10.6 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin domain Ig_6 PF18452.1 EMC88724.1 - 0.019 14.5 0.0 0.85 9.2 0.1 2.6 2 0 0 2 2 2 0 Immunoglobulin domain Flo11 PF10182.9 EMC88724.1 - 0.084 13.0 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Flo11 domain SEEK1 PF15357.6 EMC88724.1 - 0.13 12.4 0.0 0.59 10.3 0.0 1.9 1 1 0 1 1 1 0 Psoriasis susceptibility 1 candidate 1 V-set PF07686.17 EMC88725.1 - 0.0007 19.7 0.0 0.0033 17.6 0.0 1.9 1 1 0 1 1 1 1 Immunoglobulin V-set domain DUF4027 PF13219.6 EMC88725.1 - 0.091 12.7 1.4 0.095 12.6 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4027) TauD PF02668.16 EMC88726.1 - 1.7e-39 136.3 0.1 2.3e-39 135.8 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 EMC88726.1 - 9.1e-08 32.6 0.1 2.2e-06 28.2 0.1 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF971) CsiD PF08943.10 EMC88726.1 - 0.00091 18.4 0.0 0.0047 16.1 0.0 1.9 2 0 0 2 2 2 1 CsiD Sprouty PF05210.13 EMC88727.1 - 5.9e-25 87.6 32.4 1.1e-24 86.7 32.4 1.5 1 0 0 1 1 1 1 Sprouty protein (Spry) 7tm_1 PF00001.21 EMC88729.1 - 1.4e-35 123.0 13.5 1.8e-35 122.5 13.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC88729.1 - 0.0018 17.7 16.8 0.0035 16.8 13.7 3.1 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC88729.1 - 0.013 15.2 7.4 0.017 14.9 7.4 1.2 1 0 0 1 1 1 0 Olfactory receptor Flp1_like PF16982.5 EMC88729.1 - 0.89 9.0 3.2 3.2 7.2 3.2 1.9 1 0 0 1 1 1 0 Putative Flagellin, Flp1-like, domain RNA_pol_L_2 PF13656.6 EMC88730.1 - 2.1e-29 101.1 0.0 2.4e-29 100.9 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EMC88730.1 - 2.3e-13 49.4 0.0 2.8e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Longin PF13774.6 EMC88731.1 - 1e-27 96.0 0.7 1.4e-27 95.6 0.7 1.2 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 EMC88731.1 - 5.2e-12 45.4 0.7 8.5e-12 44.7 0.7 1.4 1 0 0 1 1 1 1 Synaptobrevin SLAIN PF15301.6 EMC88732.1 - 2.3e-137 458.8 56.1 2.7e-117 392.7 50.4 2.0 1 1 1 2 2 2 2 SLAIN motif-containing family 3Beta_HSD PF01073.19 EMC88733.1 - 1.3e-36 126.0 0.0 1.4e-36 125.9 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EMC88733.1 - 1.4e-15 57.4 0.0 1.6e-15 57.3 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMC88733.1 - 0.0017 17.8 0.0 0.0018 17.7 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EMC88733.1 - 0.0046 16.1 0.0 0.0049 16.0 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain EF-hand_1 PF00036.32 EMC88734.1 - 2.3e-33 111.3 10.5 1.7e-08 33.4 1.5 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EMC88734.1 - 3.8e-29 100.9 6.7 2.7e-14 53.4 0.0 2.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EMC88734.1 - 7.8e-26 87.8 7.8 2.2e-08 33.3 0.0 4.5 4 2 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EMC88734.1 - 2.3e-21 75.4 10.3 4.5e-11 42.4 0.8 3.4 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 EMC88734.1 - 9.4e-16 57.9 0.2 1.1e-06 28.9 0.0 2.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EMC88734.1 - 3e-13 48.6 11.7 0.0009 18.6 1.5 4.6 4 0 0 4 4 4 4 EF hand EF-hand_4 PF12763.7 EMC88734.1 - 1.7e-05 24.7 4.4 0.63 10.0 1.4 3.4 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 EMC88734.1 - 6.9e-05 23.1 1.2 0.087 13.2 0.3 2.9 1 1 1 3 3 3 2 EF-hand domain SurA_N_3 PF13624.6 EMC88734.1 - 0.0012 18.7 0.9 0.21 11.3 0.4 2.1 1 1 1 2 2 2 2 SurA N-terminal domain SPARC_Ca_bdg PF10591.9 EMC88734.1 - 0.0018 18.6 0.1 1.5 9.2 0.2 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region SurA_N_2 PF13623.6 EMC88734.1 - 0.0043 16.9 1.3 0.52 10.2 0.2 2.6 2 1 1 3 3 3 1 SurA N-terminal domain PMBR PF09373.10 EMC88734.1 - 0.0053 16.9 0.2 34 4.8 0.0 4.5 4 1 1 5 5 5 0 Pseudomurein-binding repeat EF-hand_11 PF08976.11 EMC88734.1 - 0.012 16.5 0.3 5.4 7.9 0.1 2.1 1 1 1 2 2 2 0 EF-hand domain ERAP1_C PF11838.8 EMC88734.1 - 0.035 13.7 0.0 0.038 13.5 0.0 1.0 1 0 0 1 1 1 0 ERAP1-like C-terminal domain Caleosin PF05042.13 EMC88734.1 - 0.04 13.8 0.5 9.5 6.1 0.0 3.1 1 1 2 3 3 3 0 Caleosin related protein Dockerin_1 PF00404.18 EMC88734.1 - 0.054 13.7 0.4 0.24 11.6 0.2 2.0 2 1 0 2 2 2 0 Dockerin type I domain LETM1 PF07766.13 EMC88734.1 - 0.11 11.8 0.7 0.21 10.9 0.3 1.6 1 1 0 1 1 1 0 LETM1-like protein EF-hand_7 PF13499.6 EMC88735.1 - 5.1e-25 87.7 2.1 1.5e-14 54.1 1.7 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EMC88735.1 - 3.4e-24 82.5 8.7 6.3e-08 31.6 0.7 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EMC88735.1 - 4.7e-19 66.6 5.9 5.3e-05 22.8 0.0 4.6 4 2 1 5 5 5 3 EF-hand domain EF-hand_8 PF13833.6 EMC88735.1 - 4.4e-16 58.5 11.2 3.1e-09 36.5 2.2 4.1 1 1 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 EMC88735.1 - 3.2e-11 43.4 0.5 1.5e-07 31.6 0.1 2.8 2 1 1 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 EMC88735.1 - 6.1e-08 31.8 19.2 0.0011 18.3 2.6 5.1 5 1 1 6 6 6 3 EF hand Dockerin_1 PF00404.18 EMC88735.1 - 0.00028 21.0 0.5 0.00051 20.2 0.0 1.7 2 0 0 2 2 2 1 Dockerin type I domain EF-hand_4 PF12763.7 EMC88735.1 - 0.00061 19.7 0.5 0.00061 19.7 0.5 2.1 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EMC88735.1 - 0.046 14.0 0.5 0.063 13.6 0.5 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region RNA_pol_Rpb4 PF03874.16 EMC88735.1 - 0.27 11.6 2.9 0.7 10.2 2.9 1.9 1 1 0 1 1 1 0 RNA polymerase Rpb4 PhetRS_B1 PF18262.1 EMC88735.1 - 0.6 10.4 4.4 5.4 7.3 1.5 2.3 2 1 0 2 2 2 0 Phe-tRNA synthetase beta subunit B1 domain DJ-1_PfpI PF01965.24 EMC88736.1 - 0.0004 20.2 1.2 0.001 18.9 1.2 1.8 1 1 0 1 1 1 1 DJ-1/PfpI family DUF587 PF04532.12 EMC88736.1 - 0.013 14.8 0.1 0.02 14.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF587) Sua5_yciO_yrdC PF01300.18 EMC88737.1 - 2.5e-31 108.6 0.0 3.5e-31 108.1 0.0 1.2 1 0 0 1 1 1 1 Telomere recombination Gpr1_Fun34_YaaH PF01184.19 EMC88737.1 - 0.00055 19.6 19.6 0.00055 19.6 19.6 4.1 3 1 0 3 3 3 1 GPR1/FUN34/yaaH family Sua5_yciO_yrdC PF01300.18 EMC88738.1 - 1.2e-24 86.8 0.0 2.5e-24 85.7 0.0 1.5 1 0 0 1 1 1 1 Telomere recombination Gpr1_Fun34_YaaH PF01184.19 EMC88738.1 - 3.9e-07 29.9 59.2 9.5e-06 25.4 20.1 3.4 3 0 0 3 3 3 3 GPR1/FUN34/yaaH family MmgE_PrpD PF03972.14 EMC88739.1 - 3.2e-126 421.4 0.0 3.6e-126 421.3 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family DUF927 PF06048.11 EMC88739.1 - 0.18 11.4 0.1 0.34 10.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF927) Sec3_C PF09763.9 EMC88740.1 - 2.5e-129 432.7 0.5 3.7e-129 432.2 0.5 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 EMC88740.1 - 1.5e-23 82.7 0.8 3e-23 81.8 0.8 1.5 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH zf-C2H2 PF00096.26 EMC88741.1 - 3.2e-14 52.5 25.6 4.4e-05 23.7 0.6 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC88741.1 - 1.8e-09 37.6 10.8 1.1e-05 25.6 3.5 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC88741.1 - 3.9e-06 27.2 23.6 0.043 14.7 4.1 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger FOXP-CC PF16159.5 EMC88741.1 - 0.015 15.9 6.5 0.5 11.0 0.2 2.5 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_11 PF16622.5 EMC88741.1 - 0.15 11.8 5.3 0.085 12.6 2.7 2.0 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_aberr PF17017.5 EMC88741.1 - 1.1 9.3 5.9 16 5.6 0.1 2.2 2 0 0 2 2 2 0 Aberrant zinc-finger zf-C2H2 PF00096.26 EMC88742.1 - 3.6e-16 58.6 23.0 3e-06 27.4 3.9 3.3 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC88742.1 - 4.6e-12 45.8 8.5 3.2e-08 33.6 1.2 3.9 4 0 0 4 4 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC88742.1 - 1.2e-07 32.0 19.3 0.0099 16.6 1.8 3.3 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 EMC88742.1 - 0.021 15.2 2.8 5.1 7.6 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_aberr PF17017.5 EMC88742.1 - 0.03 14.5 2.3 4.1 7.5 0.4 2.2 2 0 0 2 2 2 0 Aberrant zinc-finger zf-C2H2_jaz PF12171.8 EMC88742.1 - 0.036 14.4 1.3 3.8 7.9 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DUF3850 PF12961.7 EMC88742.1 - 0.16 12.0 0.0 0.33 11.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3850) zf-C2H2_8 PF15909.5 EMC88742.1 - 0.2 12.0 3.7 0.43 10.9 3.6 1.7 1 1 0 1 1 1 0 C2H2-type zinc ribbon FOXP-CC PF16159.5 EMC88742.1 - 0.33 11.6 5.1 3.3 8.4 1.1 2.4 1 1 1 2 2 2 0 FOXP coiled-coil domain zf_C2H2_ZHX PF18387.1 EMC88742.1 - 1.9 8.2 3.7 3.2 7.4 0.1 2.5 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_6 PF13912.6 EMC88742.1 - 4.8 7.3 10.4 0.33 11.0 0.8 2.9 2 1 0 2 2 2 0 C2H2-type zinc finger Gtr1_RagA PF04670.12 EMC88743.1 - 1.3e-108 361.7 1.2 1.6e-108 361.4 1.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EMC88743.1 - 7.7e-09 35.8 0.0 2.8e-08 34.0 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMC88743.1 - 1e-08 34.9 0.0 2.3e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Ras family Arf PF00025.21 EMC88743.1 - 2.1e-08 33.8 0.1 3.7e-08 33.0 0.0 1.5 1 1 1 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC88743.1 - 9.5e-07 28.9 0.0 3.1e-06 27.2 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC88743.1 - 0.0016 18.1 0.0 0.002 17.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EMC88743.1 - 0.0051 16.3 0.0 0.009 15.5 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit DUF815 PF05673.13 EMC88743.1 - 0.018 14.2 2.4 0.21 10.7 0.8 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF815) PduV-EutP PF10662.9 EMC88743.1 - 0.026 14.3 0.2 0.092 12.5 0.1 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 EMC88743.1 - 0.027 15.0 0.2 0.053 14.0 0.2 1.6 1 1 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 EMC88743.1 - 0.039 13.8 0.2 2.6 7.9 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase SecA_DEAD PF07517.14 EMC88743.1 - 0.052 12.8 0.0 0.081 12.2 0.0 1.3 1 0 0 1 1 1 0 SecA DEAD-like domain AAA_24 PF13479.6 EMC88743.1 - 0.078 12.7 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 EMC88743.1 - 0.18 11.5 0.0 0.24 11.2 0.0 1.5 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_29 PF13555.6 EMC88743.1 - 0.21 11.4 0.3 0.4 10.4 0.3 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain G-alpha PF00503.20 EMC88743.1 - 1.2 8.2 7.9 5.6 6.0 0.8 2.9 2 1 1 3 3 3 0 G-protein alpha subunit DUF5099 PF17025.5 EMC88743.1 - 2.5 8.5 5.7 19 5.7 0.2 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF5099) DUF4606 PF15379.6 EMC88744.1 - 1.1e-17 64.2 2.4 1.1e-17 64.1 2.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4606) WTX PF09422.10 EMC88746.1 - 5.5e-69 233.5 14.9 6.7e-32 111.2 1.3 3.0 1 1 2 3 3 3 3 WTX protein Ank_2 PF12796.7 EMC88747.1 - 7.3e-25 87.4 0.0 2e-11 44.3 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC88747.1 - 5.1e-22 75.6 0.8 0.00061 20.1 0.0 5.9 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.30 EMC88747.1 - 1.1e-21 76.3 2.7 0.00036 20.9 0.0 5.4 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.6 EMC88747.1 - 1.3e-17 63.9 0.8 5.1e-09 36.5 0.0 4.7 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC88747.1 - 3.1e-17 62.4 0.7 6e-05 23.2 0.0 5.3 3 2 3 6 6 6 4 Ankyrin repeats (many copies) SOCS_box PF07525.16 EMC88747.1 - 2.3e-05 24.6 0.3 6.3e-05 23.2 0.3 1.8 1 0 0 1 1 1 1 SOCS box Myotub-related PF06602.14 EMC88748.1 - 4.5e-145 483.0 0.0 5.8e-145 482.6 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.27 EMC88748.1 - 0.00065 19.3 0.0 0.0013 18.3 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Vps36_ESCRT-II PF11605.8 EMC88748.1 - 0.0022 18.1 0.0 0.0042 17.2 0.0 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 Y_phosphatase2 PF03162.13 EMC88748.1 - 0.004 16.8 0.0 0.26 10.9 0.0 2.4 2 0 0 2 2 2 1 Tyrosine phosphatase family GRAM PF02893.20 EMC88748.1 - 0.0041 17.0 0.0 0.012 15.5 0.0 1.7 2 0 0 2 2 2 1 GRAM domain DSPc PF00782.20 EMC88748.1 - 0.0044 16.8 0.1 0.025 14.4 0.0 2.1 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC88748.1 - 0.013 15.5 0.0 0.035 14.1 0.0 1.7 2 0 0 2 2 2 0 Tyrosine phosphatase family LIM PF00412.22 EMC88749.1 - 1.9e-12 47.2 3.2 3.3e-12 46.4 3.2 1.4 1 0 0 1 1 1 1 LIM domain TRAM_LAG1_CLN8 PF03798.16 EMC88750.1 - 2e-41 141.9 28.9 2.3e-41 141.7 28.9 1.0 1 0 0 1 1 1 1 TLC domain Homeodomain PF00046.29 EMC88750.1 - 0.0014 18.4 0.3 0.0025 17.6 0.3 1.4 1 0 0 1 1 1 1 Homeodomain NAD_Gly3P_dh_N PF01210.23 EMC88751.1 - 1.8e-55 187.2 0.1 1.1e-54 184.7 0.0 2.0 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 EMC88751.1 - 1.5e-49 167.9 0.8 2.5e-49 167.2 0.4 1.5 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.17 EMC88751.1 - 0.0063 17.1 2.0 0.14 12.8 0.2 3.2 3 1 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent ASC PF00858.24 EMC88752.1 - 3.5e-103 345.9 0.1 4.2e-103 345.7 0.1 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel DUF4074 PF13293.6 EMC88752.1 - 0.4 11.0 2.3 0.32 11.3 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4074) HLH PF00010.26 EMC88753.1 - 2.5e-16 59.4 0.4 4.2e-16 58.6 0.4 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain HTH_51 PF18558.1 EMC88753.1 - 0.0019 18.0 0.0 0.003 17.4 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain DUF773 PF05600.12 EMC88753.1 - 0.015 14.1 0.1 0.019 13.7 0.1 1.1 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 PIP5K PF01504.18 EMC88754.1 - 2.3e-92 309.1 0.2 3e-92 308.7 0.2 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Frataxin_Cyay PF01491.16 EMC88755.1 - 4.5e-37 126.4 0.0 5.2e-37 126.2 0.0 1.0 1 0 0 1 1 1 1 Frataxin-like domain PDZ PF00595.24 EMC88756.1 - 3e-44 149.2 7.7 3.7e-15 56.0 0.3 3.4 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 EMC88756.1 - 9.3e-21 73.4 3.6 1e-06 28.5 0.0 3.5 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 EMC88756.1 - 2.2e-14 53.5 2.0 0.00042 20.6 0.1 3.6 3 0 0 3 3 3 3 PDZ domain Guanylate_kin PF00625.21 EMC88756.1 - 1.3e-12 47.8 0.1 2.7e-12 46.7 0.1 1.5 1 0 0 1 1 1 1 Guanylate kinase SH3_2 PF07653.17 EMC88756.1 - 1.5e-08 34.2 0.7 1.4e-07 31.1 0.0 3.0 4 0 0 4 4 4 1 Variant SH3 domain SH3_1 PF00018.28 EMC88756.1 - 0.00023 20.7 0.0 0.0033 17.0 0.0 2.9 2 0 0 2 2 2 1 SH3 domain C1q PF00386.21 EMC88757.1 - 1.3e-11 44.8 0.0 1.4e-11 44.7 0.0 1.0 1 0 0 1 1 1 1 C1q domain TNF PF00229.18 EMC88757.1 - 0.065 13.2 0.0 0.065 13.2 0.0 1.0 1 0 0 1 1 1 0 TNF(Tumour Necrosis Factor) family DnaJ PF00226.31 EMC88758.1 - 1.9e-13 50.3 0.0 2.1e-13 50.1 0.0 1.0 1 0 0 1 1 1 1 DnaJ domain SLATT_5 PF18160.1 EMC88758.1 - 0.055 12.8 0.1 0.066 12.5 0.1 1.0 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF1387 PF07139.11 EMC88759.1 - 7.1e-25 88.4 4.6 3.2e-22 79.7 1.3 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF1387) CUE PF02845.16 EMC88759.1 - 0.08 12.7 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 CUE domain DUF1296 PF06972.11 EMC88759.1 - 0.15 12.2 0.0 0.29 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) Fijivirus_P9-2 PF06837.11 EMC88759.1 - 0.19 11.2 0.1 0.32 10.4 0.1 1.3 1 0 0 1 1 1 0 Fijivirus P9-2 protein CTD PF12815.7 EMC88760.1 - 2.6 8.7 136.3 60 4.3 14.7 10.1 1 1 13 14 14 14 0 Spt5 C-terminal nonapeptide repeat binding Spt4 Integrin_alpha PF00357.20 EMC88761.1 - 0.12 12.4 0.8 0.2 11.7 0.8 1.3 1 0 0 1 1 1 0 Integrin alpha cytoplasmic region Cation_ATPase_N PF00690.26 EMC88761.1 - 0.15 11.8 0.3 0.28 10.9 0.3 1.3 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus LapA_dom PF06305.11 EMC88761.1 - 0.23 11.3 2.8 0.34 10.7 2.8 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain adh_short PF00106.25 EMC88762.1 - 3.3e-23 82.2 0.0 4.5e-23 81.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC88762.1 - 3.1e-17 62.9 0.0 4e-17 62.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 EMC88762.1 - 0.0027 17.1 0.0 0.0034 16.8 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) DUF2115 PF09888.9 EMC88762.1 - 0.058 13.9 0.0 0.085 13.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) SAP PF02037.27 EMC88764.1 - 2.8e-10 39.7 1.9 5.4e-09 35.6 1.4 2.5 2 0 0 2 2 2 1 SAP domain PBP_sp32 PF07222.12 EMC88764.1 - 2.4 7.5 9.2 0.52 9.7 5.7 1.6 2 0 0 2 2 2 0 Proacrosin binding protein sp32 Gasdermin PF04598.12 EMC88765.1 - 8.4e-37 126.9 0.9 9.4e-37 126.7 0.9 1.0 1 0 0 1 1 1 1 Gasdermin pore forming domain Guanylate_kin PF00625.21 EMC88766.1 - 3.6e-49 166.9 0.0 6.8e-49 166.0 0.0 1.5 1 0 0 1 1 1 1 Guanylate kinase L27 PF02828.16 EMC88766.1 - 2.3e-29 100.9 1.4 1.6e-17 63.0 0.1 3.2 3 0 0 3 3 3 2 L27 domain SH3_2 PF07653.17 EMC88766.1 - 1.1e-11 44.2 0.3 3.8e-11 42.5 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain PDZ PF00595.24 EMC88766.1 - 8.7e-11 42.0 0.9 1.8e-10 41.0 0.9 1.6 1 0 0 1 1 1 1 PDZ domain SH3_1 PF00018.28 EMC88766.1 - 4.1e-06 26.3 0.1 1.1e-05 24.9 0.1 1.8 1 0 0 1 1 1 1 SH3 domain PDZ_6 PF17820.1 EMC88766.1 - 3.5e-05 23.6 0.1 8.1e-05 22.4 0.1 1.6 1 0 0 1 1 1 1 PDZ domain SH3_9 PF14604.6 EMC88766.1 - 4.8e-05 23.1 0.0 0.0001 22.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PDZ_2 PF13180.6 EMC88766.1 - 0.00016 21.9 0.1 0.00041 20.6 0.1 1.6 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 EMC88766.1 - 0.00058 19.8 0.1 0.013 15.5 0.1 2.8 2 1 0 2 2 2 1 Tricorn protease PDZ domain zf-RanBP PF00641.18 EMC88768.1 - 6.6e-08 31.7 2.1 1.1e-07 31.0 2.1 1.3 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Maf1 PF09174.10 EMC88769.1 - 7e-65 218.4 0.0 8.8e-65 218.1 0.0 1.1 1 0 0 1 1 1 1 Maf1 regulator Bacillus_HBL PF05791.11 EMC88770.1 - 0.00042 20.2 40.0 0.037 13.8 1.2 4.4 3 1 1 4 4 4 3 Bacillus haemolytic enterotoxin (HBL) CALCOCO1 PF07888.11 EMC88770.1 - 0.0016 17.4 30.6 0.0016 17.4 30.6 2.4 2 0 0 2 2 2 1 Calcium binding and coiled-coil domain (CALCOCO1) like DUF4201 PF13870.6 EMC88770.1 - 0.0088 15.8 19.2 0.0088 15.8 19.2 3.9 3 1 0 3 3 3 1 Domain of unknown function (DUF4201) Uso1_p115_C PF04871.13 EMC88770.1 - 0.02 15.3 12.8 0.02 15.3 12.8 5.3 1 1 3 4 4 4 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF3584 PF12128.8 EMC88770.1 - 0.18 9.3 73.0 0.5 7.8 29.7 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3584) Fez1 PF06818.15 EMC88770.1 - 0.22 11.9 75.5 0.043 14.3 6.4 4.1 1 1 2 3 3 3 0 Fez1 Golgin_A5 PF09787.9 EMC88770.1 - 3.2 7.1 79.2 0.52 9.7 22.0 3.4 2 2 1 3 3 3 0 Golgin subfamily A member 5 Fib_alpha PF08702.10 EMC88770.1 - 3.9 7.6 60.9 0.022 14.9 8.4 5.2 2 2 2 5 5 5 0 Fibrinogen alpha/beta chain family Pellino PF04710.14 EMC88771.1 - 5e-218 723.7 0.1 5.6e-218 723.6 0.1 1.0 1 0 0 1 1 1 1 Pellino Prok-RING_4 PF14447.6 EMC88771.1 - 0.0052 16.6 8.2 1.5 8.7 3.9 3.5 2 1 0 2 2 2 2 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EMC88771.1 - 0.009 15.9 8.8 0.35 10.8 0.9 3.3 2 2 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC88771.1 - 0.55 10.2 0.1 0.55 10.2 0.1 3.6 3 1 1 4 4 4 0 zinc-RING finger domain zf-RING_2 PF13639.6 EMC88771.1 - 1.2 9.5 13.2 0.64 10.4 0.5 3.2 3 1 0 3 3 3 0 Ring finger domain DUF2723 PF11028.8 EMC88773.1 - 2.6e-16 60.0 1.4 8.4e-16 58.4 1.4 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2723) TF_Otx PF03529.13 EMC88774.1 - 7.9e-33 112.7 14.8 7.9e-33 112.7 14.8 2.7 2 1 1 3 3 3 1 Otx1 transcription factor Homeodomain PF00046.29 EMC88774.1 - 5.8e-22 77.3 2.4 9e-22 76.7 2.4 1.3 1 0 0 1 1 1 1 Homeodomain NUDE_C PF04880.13 EMC88774.1 - 0.085 13.3 2.8 0.17 12.3 2.8 1.6 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region SatD PF16264.5 EMC88774.1 - 0.19 11.3 0.1 0.29 10.7 0.1 1.2 1 0 0 1 1 1 0 SatD family (SatD) Sec10 PF07393.11 EMC88775.1 - 6.2e-151 504.2 31.7 1.1e-113 381.1 15.2 3.5 2 1 1 3 3 3 2 Exocyst complex component Sec10 DUF1804 PF08822.11 EMC88775.1 - 0.12 12.4 0.1 0.12 12.4 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1804) V_ATPase_I PF01496.19 EMC88775.1 - 0.39 8.6 17.0 0.031 12.2 12.2 1.5 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Phasin PF05597.11 EMC88775.1 - 1.3 9.0 8.1 1.7 8.6 0.9 3.7 4 0 0 4 4 4 0 Poly(hydroxyalcanoate) granule associated protein (phasin) EF-G-binding_N PF07299.11 EMC88775.1 - 2.4 8.7 9.6 4.4 7.9 2.9 3.7 2 1 0 2 2 2 0 Elongation factor G-binding protein, N-terminal BLOC1_2 PF10046.9 EMC88775.1 - 5.4 7.4 10.8 0.17 12.2 2.7 2.8 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cnn_1N PF07989.11 EMC88775.1 - 8.2 6.7 12.6 8.3 6.7 1.2 3.4 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Acetyltransf_1 PF00583.25 EMC88776.1 - 1.1e-17 64.3 0.0 1.7e-17 63.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMC88776.1 - 5.9e-12 45.6 0.0 9.3e-12 45.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMC88776.1 - 7.2e-12 45.6 0.0 1.2e-11 44.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMC88776.1 - 5.7e-09 35.8 0.0 1.1e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 EMC88776.1 - 6.4e-05 22.7 0.0 0.00011 21.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EMC88776.1 - 0.00016 22.4 0.0 0.00023 21.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EMC88776.1 - 0.0015 18.6 0.0 0.0023 18.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain TGS PF02824.21 EMC88776.1 - 0.17 12.0 0.0 0.42 10.7 0.0 1.7 2 0 0 2 2 2 0 TGS domain DUF4619 PF15398.6 EMC88778.1 - 3.4e-86 289.5 7.4 8e-85 284.9 7.4 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4619) SLC35F PF06027.12 EMC88779.1 - 8.2e-06 25.5 10.1 1.2e-05 24.9 10.1 1.3 1 0 0 1 1 1 1 Solute carrier family 35 EamA PF00892.20 EMC88779.1 - 2.8e-05 24.3 12.1 2.8e-05 24.3 12.1 3.1 2 2 0 2 2 2 1 EamA-like transporter family DUF1418 PF07214.12 EMC88779.1 - 2.3 8.1 4.3 1.9 8.4 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1418) Mab-21 PF03281.14 EMC88780.1 - 1.7e-12 47.2 0.3 1.2e-11 44.5 0.3 2.0 1 1 0 1 1 1 1 Mab-21 protein zf-TRM13_CCCH PF11722.8 EMC88780.1 - 0.036 13.8 0.8 0.59 10.0 0.2 2.5 2 0 0 2 2 2 0 CCCH zinc finger in TRM13 protein DUF4696 PF15767.5 EMC88781.1 - 1.5e-51 175.7 25.2 1.5e-51 175.7 25.2 1.5 2 0 0 2 2 1 1 Domain of unknown function (DUF4696) DUF4611 PF15387.6 EMC88781.1 - 0.00019 21.6 6.3 0.00057 20.1 6.3 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4611) Nop14 PF04147.12 EMC88781.1 - 0.0015 16.8 6.1 0.0018 16.6 6.1 1.2 1 0 0 1 1 1 1 Nop14-like family BUD22 PF09073.10 EMC88781.1 - 0.0038 16.6 2.2 0.0041 16.5 2.2 1.3 1 0 0 1 1 1 1 BUD22 FAM176 PF14851.6 EMC88781.1 - 0.015 15.0 7.4 0.78 9.4 8.4 2.4 2 0 0 2 2 2 0 FAM176 family RNA_pol_3_Rpc31 PF11705.8 EMC88781.1 - 0.024 14.9 9.8 0.024 14.9 9.8 1.8 2 0 0 2 2 1 0 DNA-directed RNA polymerase III subunit Rpc31 Plasmodium_Vir PF05795.11 EMC88781.1 - 0.026 14.0 1.5 0.027 13.9 0.7 1.4 1 1 0 1 1 1 0 Plasmodium vivax Vir protein FHIPEP PF00771.20 EMC88781.1 - 0.045 12.2 0.8 4.4 5.6 0.4 2.2 1 1 0 2 2 2 0 FHIPEP family Voldacs PF03517.13 EMC88781.1 - 0.052 13.7 9.6 0.093 12.9 9.4 1.7 1 1 0 1 1 1 0 Regulator of volume decrease after cellular swelling PPP4R2 PF09184.11 EMC88781.1 - 0.058 13.0 9.2 0.091 12.3 9.2 1.4 1 0 0 1 1 1 0 PPP4R2 DNA_pol_phi PF04931.13 EMC88781.1 - 0.066 11.3 14.4 0.097 10.8 14.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi Rax2 PF12768.7 EMC88781.1 - 0.067 12.6 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 Cortical protein marker for cell polarity Na_trans_assoc PF06512.13 EMC88781.1 - 0.15 12.4 5.4 0.19 12.0 5.3 1.4 1 1 0 1 1 1 0 Sodium ion transport-associated Paf1 PF03985.13 EMC88781.1 - 0.23 10.4 11.0 0.4 9.6 11.0 1.3 1 0 0 1 1 1 0 Paf1 Med17 PF10156.9 EMC88781.1 - 0.31 9.7 9.1 1.2 7.7 5.5 2.1 2 0 0 2 2 2 0 Subunit 17 of Mediator complex CAF1A PF12253.8 EMC88781.1 - 0.42 10.8 13.9 8.9 6.6 12.4 2.4 2 0 0 2 2 2 0 Chromatin assembly factor 1 subunit A Radial_spoke PF04712.12 EMC88781.1 - 0.6 9.0 11.4 0.96 8.3 11.4 1.3 1 0 0 1 1 1 0 Radial spokehead-like protein Pox_Ag35 PF03286.14 EMC88781.1 - 0.79 9.5 10.2 0.17 11.7 5.9 2.0 2 0 0 2 2 2 0 Pox virus Ag35 surface protein RRN3 PF05327.11 EMC88781.1 - 0.96 7.9 7.8 1.5 7.3 7.8 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 HSP90 PF00183.18 EMC88781.1 - 1.1 8.1 7.7 1.7 7.5 7.7 1.2 1 0 0 1 1 1 0 Hsp90 protein RXT2_N PF08595.11 EMC88781.1 - 1.1 9.2 7.5 0.15 12.0 3.2 1.8 2 0 0 2 2 2 0 RXT2-like, N-terminal Astro_capsid_p PF12226.8 EMC88781.1 - 1.1 8.3 10.5 1.8 7.7 10.5 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein VID27_N PF17748.1 EMC88781.1 - 1.4 8.7 8.1 2.4 8.0 8.1 1.3 1 0 0 1 1 1 0 VID27 N-terminal region CDC45 PF02724.14 EMC88781.1 - 7.7 4.7 11.9 13 3.9 11.9 1.3 1 0 0 1 1 1 0 CDC45-like protein bPH_6 PF10756.9 EMC88782.1 - 0.025 14.7 2.5 1.3 9.2 0.2 2.3 2 0 0 2 2 2 0 Bacterial PH domain KH_1 PF00013.29 EMC88783.1 - 1.1e-20 73.2 2.0 1.8e-14 53.3 0.3 2.3 2 0 0 2 2 2 2 KH domain zf-C3HC4_3 PF13920.6 EMC88783.1 - 0.028 14.3 1.2 0.052 13.4 1.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) KH_2 PF07650.17 EMC88783.1 - 0.065 13.1 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 KH domain Ras PF00071.22 EMC88784.1 - 2.1e-59 199.8 0.5 2.6e-59 199.5 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC88784.1 - 5.1e-32 110.6 0.9 8e-32 110.0 0.2 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC88784.1 - 2.1e-13 50.1 0.1 3e-13 49.6 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC88784.1 - 6.7e-08 32.6 0.2 1.9e-07 31.2 0.1 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC88784.1 - 1.3e-06 28.4 0.2 0.051 13.5 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase KAP_NTPase PF07693.14 EMC88784.1 - 1.1e-05 24.9 0.0 1.4e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 KAP family P-loop domain Gtr1_RagA PF04670.12 EMC88784.1 - 2e-05 24.0 0.2 4e-05 23.1 0.2 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EMC88784.1 - 4.3e-05 23.0 0.2 0.0018 17.7 0.0 2.1 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 EMC88784.1 - 0.00046 20.5 0.2 0.0088 16.3 0.0 2.6 1 1 1 2 2 2 1 AAA domain FeoB_N PF02421.18 EMC88784.1 - 0.0012 18.4 0.8 0.011 15.3 0.8 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_14 PF13173.6 EMC88784.1 - 0.0023 18.0 0.1 0.012 15.6 0.0 1.9 1 1 1 2 2 2 1 AAA domain AAA_7 PF12775.7 EMC88784.1 - 0.0029 17.1 0.1 0.0061 16.1 0.1 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region GTP_EFTU PF00009.27 EMC88784.1 - 0.0033 17.0 0.5 0.02 14.4 0.5 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_28 PF13521.6 EMC88784.1 - 0.0079 16.5 0.6 0.74 10.0 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EMC88784.1 - 0.0099 16.3 0.3 0.026 14.9 0.3 1.9 1 1 0 1 1 1 1 AAA ATPase domain PduV-EutP PF10662.9 EMC88784.1 - 0.01 15.6 0.1 0.046 13.5 0.0 2.1 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Septin PF00735.18 EMC88784.1 - 0.012 15.0 0.6 0.23 10.7 0.1 2.1 2 0 0 2 2 2 0 Septin AAA_24 PF13479.6 EMC88784.1 - 0.013 15.3 0.4 0.03 14.0 0.0 1.9 2 1 1 3 3 3 0 AAA domain AAA_5 PF07728.14 EMC88784.1 - 0.014 15.4 0.1 0.036 14.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) TniB PF05621.11 EMC88784.1 - 0.021 14.2 0.4 0.1 12.0 0.0 2.0 2 1 0 2 2 2 0 Bacterial TniB protein Sigma54_activat PF00158.26 EMC88784.1 - 0.045 13.5 0.2 2.3 7.9 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain ABC_tran PF00005.27 EMC88784.1 - 0.066 13.7 1.9 0.24 11.9 1.9 2.0 1 1 0 1 1 1 0 ABC transporter NACHT PF05729.12 EMC88784.1 - 0.067 13.1 0.0 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 NACHT domain cobW PF02492.19 EMC88784.1 - 0.074 12.6 0.3 3 7.4 0.0 2.3 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF3533 PF12051.8 EMC88784.1 - 0.22 10.4 1.1 0.27 10.1 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) Robl_LC7 PF03259.17 EMC88785.1 - 2.2e-13 49.8 0.1 3e-13 49.4 0.1 1.2 1 0 0 1 1 1 1 Roadblock/LC7 domain ubiquitin PF00240.23 EMC88786.1 - 9.5e-13 47.7 0.1 1.6e-12 47.0 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin family STI1 PF17830.1 EMC88786.1 - 2.4e-08 33.8 60.1 0.00025 20.9 11.7 7.1 5 2 2 7 7 7 5 STI1 domain UBA PF00627.31 EMC88786.1 - 1.1e-06 28.4 0.9 1.1e-06 28.4 0.9 2.5 2 0 0 2 2 2 1 UBA/TS-N domain Rad60-SLD PF11976.8 EMC88786.1 - 0.0019 18.0 0.1 0.0035 17.1 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Arm_2 PF04826.13 EMC88786.1 - 0.0068 15.9 0.3 0.0068 15.9 0.3 2.9 3 0 0 3 3 3 1 Armadillo-like Ubiquitin_5 PF18037.1 EMC88786.1 - 0.007 16.7 0.2 0.018 15.4 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain HOIP-UBA PF16678.5 EMC88786.1 - 0.05 13.6 0.0 0.099 12.6 0.0 1.5 1 0 0 1 1 1 0 HOIP UBA domain pair CUE PF02845.16 EMC88786.1 - 0.053 13.2 0.0 0.25 11.1 0.0 2.3 1 0 0 1 1 1 0 CUE domain Rad60-SLD_2 PF13881.6 EMC88786.1 - 0.086 12.9 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like ComX PF05952.12 EMC88786.1 - 1 9.4 9.1 35 4.4 0.2 5.1 4 1 1 5 5 5 0 Bacillus competence pheromone ComX G-patch PF01585.23 EMC88788.1 - 1.1e-06 28.5 0.2 2.8e-06 27.1 0.2 1.8 1 0 0 1 1 1 1 G-patch domain MDMPI_C PF07398.11 EMC88788.1 - 0.066 14.1 0.4 0.15 13.0 0.4 1.6 1 0 0 1 1 1 0 MDMPI C-terminal domain UvrD-helicase PF00580.21 EMC88788.1 - 0.45 10.0 8.1 0.59 9.6 8.1 1.1 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain YjeF_N PF03853.15 EMC88789.1 - 8.7e-37 126.6 0.0 1e-36 126.4 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus wnt PF00110.19 EMC88790.1 - 1.8e-121 405.5 24.2 2.1e-121 405.2 24.2 1.0 1 0 0 1 1 1 1 wnt family EndoU_bacteria PF14436.6 EMC88790.1 - 0.15 12.4 0.0 0.51 10.7 0.0 1.8 1 1 0 1 1 1 0 Bacterial EndoU nuclease K_channel_TID PF07941.11 EMC88790.1 - 3.4 8.2 6.8 1.4 9.4 0.2 2.7 3 0 0 3 3 3 0 Potassium channel Kv1.4 tandem inactivation domain VWA_N PF08399.11 EMC88791.1 - 2.1e-34 118.7 0.2 4.6e-34 117.5 0.2 1.6 1 0 0 1 1 1 1 VWA N-terminal VGCC_alpha2 PF08473.11 EMC88791.1 - 2.5e-31 109.0 3.5 3.8e-31 108.3 3.5 1.2 1 0 0 1 1 1 1 Neuronal voltage-dependent calcium channel alpha 2acd dCache_1 PF02743.18 EMC88791.1 - 3.7e-14 53.1 3.0 1.7e-10 41.1 0.0 3.8 3 1 1 4 4 4 2 Cache domain VWA_3 PF13768.6 EMC88791.1 - 4.6e-14 52.7 0.0 9.3e-14 51.6 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EMC88791.1 - 5.4e-12 46.3 0.1 1e-11 45.4 0.1 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EMC88791.1 - 1.3e-09 38.6 0.0 2.7e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain dCache_2 PF08269.11 EMC88791.1 - 0.00097 18.4 0.1 0.0037 16.5 0.1 1.9 2 0 0 2 2 2 1 Cache domain Cache_3-Cache_2 PF17201.4 EMC88791.1 - 0.0079 15.5 0.0 0.024 13.9 0.1 1.7 2 0 0 2 2 2 1 Cache 3/Cache 2 fusion domain VWA_CoxE PF05762.14 EMC88791.1 - 0.028 13.8 0.0 0.05 13.0 0.0 1.3 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein LRR_8 PF13855.6 EMC88792.1 - 4.9e-24 83.9 19.2 1.5e-16 59.9 4.9 3.6 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 EMC88792.1 - 6.1e-09 36.0 21.5 0.00063 20.1 3.3 3.6 2 1 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC88792.1 - 1.3e-08 34.6 6.3 0.00031 20.3 0.8 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_5 PF13306.6 EMC88792.1 - 1.4e-07 31.5 0.1 1e-06 28.8 0.5 2.0 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EMC88792.1 - 2.4e-05 24.2 13.1 0.046 14.3 0.2 4.8 5 0 0 5 5 5 2 Leucine Rich Repeat LRRNT PF01462.18 EMC88792.1 - 0.0031 17.1 1.5 0.0031 17.1 1.5 2.3 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 EMC88792.1 - 0.042 13.9 14.3 0.16 12.1 0.1 4.6 5 0 0 5 5 5 0 Leucine Rich repeat SelK_SelG PF10961.8 EMC88793.1 - 2.6e-26 92.1 1.0 2.9e-26 91.9 1.0 1.0 1 0 0 1 1 1 1 Selenoprotein SelK_SelG Actin PF00022.19 EMC88794.1 - 8e-30 103.7 0.0 5.2e-15 55.0 0.0 2.7 2 1 0 2 2 2 2 Actin Actin_micro PF17003.5 EMC88794.1 - 2e-15 56.9 0.1 6.5e-08 32.1 0.1 2.1 2 0 0 2 2 2 2 Putative actin-like family GMC_oxred_N PF00732.19 EMC88795.1 - 4.4e-96 321.7 0.0 5.8e-96 321.4 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMC88795.1 - 1.2e-40 139.3 0.0 2e-40 138.6 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 EMC88795.1 - 6.9e-05 22.6 0.0 0.00011 22.0 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMC88795.1 - 0.00011 21.4 0.0 0.4 9.7 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.12 EMC88795.1 - 0.00021 20.4 0.0 0.0003 19.9 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EMC88795.1 - 0.0023 17.2 0.0 1.1 8.5 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMC88795.1 - 0.0085 15.4 0.0 0.032 13.5 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMC88795.1 - 0.029 14.6 0.0 0.083 13.1 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Ion_trans PF00520.31 EMC88796.1 - 1.8e-252 833.0 86.9 1e-70 237.8 14.2 4.1 4 0 0 4 4 4 4 Ion transport protein CAC1F_C PF16885.5 EMC88796.1 - 2.6e-74 251.1 3.7 2.6e-74 251.1 3.7 2.7 2 1 0 2 2 2 1 Voltage-gated calcium channel subunit alpha, C-term Ca_chan_IQ PF08763.11 EMC88796.1 - 7e-31 106.3 0.2 1.6e-30 105.1 0.2 1.7 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain GPHH PF16905.5 EMC88796.1 - 1.1e-28 98.7 0.1 3.4e-28 97.2 0.1 1.9 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.12 EMC88796.1 - 8.5e-11 41.2 26.0 5.1e-10 38.6 7.2 9.5 7 3 2 9 9 9 3 Polycystin cation channel DUF4834 PF16118.5 EMC88796.1 - 0.039 14.9 0.1 0.039 14.9 0.1 8.8 9 0 0 9 9 9 0 Domain of unknown function (DUF4834) Rer1 PF03248.13 EMC88796.1 - 0.053 13.3 9.3 0.31 10.7 2.5 4.4 4 0 0 4 4 4 0 Rer1 family DUF5305 PF17231.2 EMC88796.1 - 0.066 12.6 0.4 3.4 7.0 0.0 3.6 3 0 0 3 3 3 0 Family of unknown function (DUF5305) NARP1 PF12569.8 EMC88796.1 - 3.7 6.4 7.5 7.5 5.3 7.5 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 EphA2_TM PF14575.6 EMC88796.1 - 7 7.6 7.1 32 5.5 0.1 5.5 6 0 0 6 6 6 0 Ephrin type-A receptor 2 transmembrane domain DCP1 PF06058.13 EMC88797.1 - 7.4e-27 93.6 0.0 1.7e-26 92.4 0.0 1.7 1 0 0 1 1 1 1 Dcp1-like decapping family mRNA_decap_C PF16741.5 EMC88797.1 - 8.9e-22 76.1 0.7 1.8e-21 75.2 0.7 1.6 1 0 0 1 1 1 1 mRNA-decapping enzyme C-terminus Transket_pyr PF02779.24 EMC88798.1 - 4.4e-41 140.5 0.0 8.8e-41 139.5 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_N PF00456.21 EMC88798.1 - 2.1e-39 135.4 0.0 4.4e-39 134.4 0.0 1.5 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transketolase_C PF02780.20 EMC88798.1 - 2.7e-32 111.2 0.4 5.5e-32 110.3 0.4 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain E1_dh PF00676.20 EMC88798.1 - 3.2e-07 29.6 0.0 9.6e-07 28.0 0.0 1.8 2 0 0 2 2 2 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 EMC88798.1 - 3.2e-06 27.0 0.1 0.00013 21.8 0.1 3.2 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 EMC88798.1 - 3e-05 23.4 0.0 0.00093 18.5 0.0 2.3 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase XFP_N PF09364.10 EMC88798.1 - 0.0037 16.1 0.1 0.017 14.0 0.0 1.8 1 1 1 2 2 2 1 XFP N-terminal domain Muskelin_N PF06588.11 EMC88799.1 - 6e-89 297.2 0.3 9.4e-89 296.6 0.3 1.3 1 0 0 1 1 1 1 Muskelin N-terminus Kelch_3 PF13415.6 EMC88799.1 - 2.6e-21 75.4 4.8 2.7e-10 40.3 0.0 5.1 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.25 EMC88799.1 - 6.1e-18 64.1 18.5 1.4e-06 27.7 0.3 6.1 6 1 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 EMC88799.1 - 4.2e-16 58.6 5.4 0.0053 17.0 0.1 6.1 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 EMC88799.1 - 3.3e-15 55.8 9.3 5.8e-05 23.0 0.1 6.1 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC88799.1 - 1.1e-14 54.0 11.8 0.00032 20.6 0.2 6.6 6 1 0 6 6 6 4 Kelch motif F5_F8_type_C PF00754.25 EMC88799.1 - 2.4e-07 30.9 0.0 5.2e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 F5/8 type C domain Kelch_2 PF07646.15 EMC88799.1 - 1.4e-05 24.9 12.3 0.1 12.6 0.1 6.1 6 1 1 7 7 7 2 Kelch motif Sad1_UNC PF07738.13 EMC88799.1 - 0.029 14.4 0.0 0.075 13.1 0.0 1.6 1 0 0 1 1 1 0 Sad1 / UNC-like C-terminal CD34_antigen PF06365.12 EMC88800.1 - 2.8e-62 210.0 2.2 3e-62 209.9 2.2 1.0 1 0 0 1 1 1 1 CD34/Podocalyxin family Rad50_zn_hook PF04423.14 EMC88800.1 - 4.3 7.2 7.1 3.4 7.6 0.9 2.4 2 0 0 2 2 2 0 Rad50 zinc hook motif LSPR PF06049.12 EMC88801.1 - 2.4 8.3 36.1 13 6.1 0.3 8.1 8 0 0 8 8 8 0 Coagulation Factor V LSPD Repeat KA1 PF02149.19 EMC88803.1 - 6.9e-21 73.8 0.0 9e-21 73.4 0.0 1.2 1 0 0 1 1 1 1 Kinase associated domain 1 HECT PF00632.25 EMC88804.1 - 2.5e-28 99.5 0.0 2.7e-28 99.4 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Alpha_kinase PF02816.18 EMC88806.1 - 1e-34 120.3 0.1 1.6e-34 119.7 0.1 1.2 1 0 0 1 1 1 1 Alpha-kinase family Tsg PF04668.12 EMC88806.1 - 0.0038 17.9 0.5 0.0081 16.8 0.2 1.5 1 1 0 1 1 1 1 Twisted gastrulation (Tsg) protein conserved region MALT1_Ig PF18703.1 EMC88807.1 - 1e-61 207.0 0.0 2.1e-61 206.0 0.0 1.6 1 0 0 1 1 1 1 MALT1 Ig-like domain Ig_2 PF13895.6 EMC88807.1 - 2.2e-24 85.6 0.2 2.4e-12 47.0 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 EMC88807.1 - 4.5e-23 81.7 0.4 1.3e-10 41.7 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Peptidase_C14 PF00656.22 EMC88807.1 - 1.4e-20 74.3 0.0 1.2e-19 71.3 0.0 2.1 1 1 0 1 1 1 1 Caspase domain ig PF00047.25 EMC88807.1 - 7.5e-15 54.9 0.4 3.8e-07 30.2 0.1 2.8 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC88807.1 - 1e-14 54.3 0.1 9.6e-06 25.6 0.0 3.0 2 2 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 EMC88807.1 - 4.9e-10 39.5 1.1 0.018 15.2 0.0 3.7 2 2 1 3 3 3 3 Immunoglobulin V-set domain Ig_4 PF16680.5 EMC88807.1 - 1e-06 28.9 0.0 0.054 13.8 0.0 2.5 2 0 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 EMC88807.1 - 2.7e-06 26.9 0.1 0.00093 18.7 0.0 3.0 2 0 0 2 2 2 1 Immunoglobulin domain Ig_5 PF16681.5 EMC88807.1 - 6.7e-06 26.4 0.1 0.0066 16.8 0.0 2.6 2 0 0 2 2 2 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 EMC88807.1 - 0.00023 21.2 0.0 0.47 10.5 0.0 2.6 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain C2-set_2 PF08205.12 EMC88807.1 - 0.014 15.5 0.2 1.4 9.1 0.0 2.6 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Glyco_transf_21 PF13506.6 EMC88807.1 - 0.06 12.8 0.0 0.13 11.7 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 21 Trehalose_PPase PF02358.16 EMC88807.1 - 0.16 11.1 0.4 0.36 9.9 0.0 1.7 2 0 0 2 2 2 0 Trehalose-phosphatase Peptidase_S24 PF00717.23 EMC88808.1 - 6.3e-11 42.1 0.1 1e-10 41.4 0.1 1.3 1 0 0 1 1 1 1 Peptidase S24-like Lectin_leg-like PF03388.13 EMC88809.1 - 7.3e-79 264.3 0.1 9.8e-79 263.9 0.1 1.2 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 EMC88809.1 - 6.9e-10 39.3 0.3 1.2e-09 38.5 0.3 1.3 1 0 0 1 1 1 1 Bacterial lectin CorA PF01544.18 EMC88809.1 - 0.00099 18.5 1.3 0.0018 17.7 1.3 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Lectin_legB PF00139.19 EMC88809.1 - 0.0015 18.1 0.0 0.0035 16.9 0.0 1.7 1 1 0 1 1 1 1 Legume lectin domain ApoLp-III PF07464.11 EMC88809.1 - 0.012 15.7 2.9 11 6.1 0.0 3.1 2 1 1 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Cytochrom_B562 PF07361.11 EMC88809.1 - 0.024 15.3 1.5 2.2 9.0 0.5 2.5 2 0 0 2 2 2 0 Cytochrome b562 Mis14 PF08641.12 EMC88809.1 - 0.081 13.2 4.0 0.91 9.8 0.4 2.6 2 1 1 3 3 3 0 Kinetochore protein Mis14 like DASH_Dad1 PF08649.10 EMC88809.1 - 0.1 12.8 0.4 0.96 9.7 0.8 2.3 2 0 0 2 2 2 0 DASH complex subunit Dad1 V-SNARE PF05008.15 EMC88809.1 - 0.25 11.8 3.6 0.36 11.2 1.2 2.6 3 0 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus SHE3 PF17078.5 EMC88809.1 - 0.7 9.6 3.7 16 5.1 1.5 2.3 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 Hemerythrin PF01814.23 EMC88809.1 - 0.74 10.4 4.4 2.5 8.7 0.1 2.9 3 0 0 3 3 3 0 Hemerythrin HHE cation binding domain Golgin_A5 PF09787.9 EMC88809.1 - 1.7 8.1 6.5 3.1 7.2 0.7 2.2 2 0 0 2 2 2 0 Golgin subfamily A member 5 OmpH PF03938.14 EMC88809.1 - 2.9 8.2 10.9 0.33 11.3 6.4 1.7 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF4404 PF14357.6 EMC88809.1 - 4.8 7.9 8.8 20 5.9 1.5 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4404) AAA_32 PF13654.6 EMC88809.1 - 8.1 5.1 8.4 30 3.2 7.1 2.0 1 1 1 2 2 2 0 AAA domain Synaphin PF05835.12 EMC88810.1 - 9.4e-48 162.1 11.6 1.3e-47 161.7 11.6 1.2 1 0 0 1 1 1 1 Synaphin protein DUF4449 PF14613.6 EMC88810.1 - 3.2 7.8 8.9 3.2 7.8 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4449) Homeodomain PF00046.29 EMC88811.1 - 1.8e-24 85.3 4.7 3e-24 84.6 4.7 1.4 1 0 0 1 1 1 1 Homeodomain OAR PF03826.17 EMC88811.1 - 4.3e-10 39.1 0.1 7.4e-10 38.3 0.1 1.4 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.11 EMC88811.1 - 0.056 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Homeobox KN domain Myosin_head PF00063.21 EMC88812.1 - 2.3e-294 977.9 1.8 2.3e-294 977.9 1.8 3.0 3 0 0 3 3 3 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 EMC88812.1 - 5e-156 521.3 279.9 6.1e-156 521.0 279.9 1.0 1 0 0 1 1 1 1 Myosin tail Filament PF00038.21 EMC88812.1 - 0.0017 18.0 18.8 0.0017 18.0 18.8 8.8 1 1 6 7 7 7 3 Intermediate filament protein IQ PF00612.27 EMC88812.1 - 0.024 14.4 3.0 0.13 12.1 1.2 2.7 2 0 0 2 2 2 0 IQ calmodulin-binding motif AAA_22 PF13401.6 EMC88812.1 - 0.066 13.5 0.0 0.066 13.5 0.0 6.0 4 3 1 5 5 5 0 AAA domain ATP-synt_ab PF00006.25 EMC88812.1 - 0.13 11.9 0.0 0.37 10.4 0.0 1.7 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_16 PF13191.6 EMC88812.1 - 0.27 11.6 0.0 0.27 11.6 0.0 6.7 2 1 0 3 3 3 0 AAA ATPase domain CTD_bind PF04818.13 EMC88814.1 - 1.6e-17 64.1 0.2 1.6e-17 64.1 0.2 2.3 3 0 0 3 3 3 1 RNA polymerase II-binding domain. CREPT PF16566.5 EMC88814.1 - 6.8e-08 32.8 0.3 6.8e-08 32.8 0.3 1.9 2 0 0 2 2 2 1 Cell-cycle alteration and expression-elevated protein in tumour Acetyltransf_11 PF13720.6 EMC88814.1 - 0.049 14.1 0.1 8.5 6.9 0.0 2.6 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Lzipper-MIP1 PF14389.6 EMC88814.1 - 0.27 11.6 1.9 45 4.4 0.0 3.4 2 1 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 PRP3 PF08572.10 EMC88815.1 - 2.4e-48 164.8 5.0 4.8e-29 101.7 0.2 4.0 4 1 0 4 4 4 2 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 EMC88815.1 - 4.6e-42 143.6 2.2 4.6e-42 143.6 2.2 2.1 3 0 0 3 3 3 1 Protein of unknown function (DUF1115) PWI PF01480.17 EMC88815.1 - 3.9e-13 49.5 0.0 9.8e-13 48.2 0.0 1.7 1 0 0 1 1 1 1 PWI domain TPX2 PF06886.11 EMC88815.1 - 0.055 13.7 0.4 0.055 13.7 0.4 5.0 6 0 0 6 6 6 0 Targeting protein for Xklp2 (TPX2) CNDH2_M PF16869.5 EMC88815.1 - 0.3 11.8 2.4 1.7 9.3 0.0 2.8 2 1 0 2 2 2 0 PF16858 UPF0767 PF15990.5 EMC88815.1 - 9.1 6.5 6.2 7.3 6.8 0.8 2.9 2 0 0 2 2 2 0 UPF0767 family LRR_9 PF14580.6 EMC88817.1 - 5.3e-16 58.6 0.5 6.8e-16 58.3 0.5 1.1 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EMC88817.1 - 1.9e-15 56.7 12.9 1.3e-08 35.0 5.8 3.3 1 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMC88817.1 - 6.2e-11 41.9 14.2 3e-07 30.1 4.7 3.3 1 1 3 4 4 4 3 Leucine rich repeat LRR_6 PF13516.6 EMC88817.1 - 3.1e-08 33.0 9.0 0.0014 18.6 0.2 4.0 3 0 0 3 3 3 3 Leucine Rich repeat LRR_1 PF00560.33 EMC88817.1 - 9.4e-05 22.5 8.5 2.2 9.2 0.1 4.4 4 0 0 4 4 4 2 Leucine Rich Repeat LRR_2 PF07723.13 EMC88817.1 - 0.31 11.8 1.6 69 4.3 0.1 3.7 4 0 0 4 4 4 0 Leucine Rich Repeat PH PF00169.29 EMC88818.1 - 8.3e-13 48.8 0.8 1.8e-12 47.7 0.8 1.6 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 EMC88818.1 - 0.001 19.4 0.6 0.013 15.9 0.6 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EMC88818.1 - 0.018 15.4 0.8 0.018 15.4 0.8 2.6 2 0 0 2 2 2 0 Pleckstrin homology domain DTW PF03942.15 EMC88818.1 - 0.024 14.3 2.1 0.045 13.4 1.1 1.9 1 1 1 2 2 2 0 DTW domain DUF3055 PF11256.8 EMC88818.1 - 0.065 13.5 0.4 1.4 9.2 0.2 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3055) Flagellin_N PF00669.20 EMC88818.1 - 0.34 11.0 4.1 0.44 10.7 2.3 2.0 1 1 1 2 2 2 0 Bacterial flagellin N-terminal helical region OTU PF02338.19 EMC88819.1 - 4.9e-24 85.2 0.0 1e-23 84.2 0.0 1.6 1 0 0 1 1 1 1 OTU-like cysteine protease MIB_HERC2 PF06701.13 EMC88819.1 - 0.78 10.0 4.6 0.63 10.3 0.1 2.4 2 0 0 2 2 2 0 Mib_herc2 RRM_1 PF00076.22 EMC88820.1 - 8.2e-41 137.7 0.0 1.7e-20 72.6 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMC88820.1 - 3e-07 30.5 0.0 0.00036 20.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif RRM_5 PF13893.6 EMC88820.1 - 7.9e-05 22.3 0.0 0.16 11.6 0.0 2.1 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.11 EMC88820.1 - 0.0015 18.1 0.1 0.098 12.4 0.0 2.4 2 0 0 2 2 2 1 Ribonuclease B OB domain Limkain-b1 PF11608.8 EMC88820.1 - 0.006 16.6 0.0 0.91 9.6 0.0 2.1 2 0 0 2 2 2 2 Limkain b1 PHM7_cyt PF14703.6 EMC88820.1 - 0.22 11.8 0.0 3.8 7.7 0.0 2.0 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter RGM_N PF06535.12 EMC88821.1 - 2.8e-68 229.3 0.1 3.3e-68 229.0 0.1 1.1 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) N-terminus RGM_C PF06534.13 EMC88821.1 - 1.5e-07 31.1 0.0 2.3e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) C-terminus VWD PF00094.25 EMC88821.1 - 0.021 15.1 0.0 0.031 14.5 0.0 1.2 1 0 0 1 1 1 0 von Willebrand factor type D domain Collagen PF01391.18 EMC88822.1 - 0.0025 17.5 60.4 1.8e+04 -41.2 60.4 6.3 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) Sad1_UNC PF07738.13 EMC88823.1 - 5.6e-26 91.1 0.0 2.9e-25 88.8 0.0 1.8 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal AIMP2_LysRS_bd PF16780.5 EMC88823.1 - 0.091 12.5 0.8 5.8 6.7 0.0 2.3 2 0 0 2 2 2 0 AIMP2 lysyl-tRNA synthetase binding domain HEAT PF02985.22 EMC88826.1 - 6.1e-40 131.8 19.1 0.00023 21.2 0.0 11.5 11 0 0 11 11 11 9 HEAT repeat HEAT_2 PF13646.6 EMC88826.1 - 9.5e-37 125.3 4.0 1.3e-14 54.4 0.0 6.4 3 2 3 6 6 6 5 HEAT repeats HEAT_EZ PF13513.6 EMC88826.1 - 8.8e-11 42.1 5.6 0.68 10.5 0.0 7.6 7 2 1 8 8 8 3 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EMC88826.1 - 2.5e-10 40.8 0.2 0.22 12.2 0.0 6.2 3 2 3 6 6 6 3 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EMC88826.1 - 4.5e-09 36.6 0.8 0.11 12.5 0.1 4.3 2 1 1 4 4 4 4 non-SMC mitotic condensation complex subunit 1 TAF6_C PF07571.13 EMC88826.1 - 0.00065 20.0 0.1 0.37 11.1 0.0 3.8 4 1 0 4 4 4 1 TAF6 C-terminal HEAT repeat domain M11L PF11099.8 EMC88826.1 - 0.0014 18.9 0.0 0.0081 16.4 0.0 2.2 2 1 0 2 2 2 1 Apoptosis regulator M11L like Adaptin_N PF01602.20 EMC88826.1 - 0.007 15.0 1.7 0.18 10.3 0.3 3.2 2 1 1 3 3 3 2 Adaptin N terminal region CLASP_N PF12348.8 EMC88826.1 - 0.0078 15.8 0.0 8.1 5.9 0.0 4.2 4 2 1 5 5 5 1 CLASP N terminal HEAT_PBS PF03130.16 EMC88826.1 - 0.071 13.8 0.0 37 5.4 0.0 4.4 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat Gag_p30 PF02093.16 EMC88827.1 - 6.1e-23 81.4 0.0 6.6e-23 81.3 0.0 1.0 1 0 0 1 1 1 1 Gag P30 core shell protein FdsD PF11390.8 EMC88827.1 - 0.098 13.0 0.2 0.28 11.6 0.1 1.8 2 0 0 2 2 2 0 NADH-dependant formate dehydrogenase delta subunit FdsD SKICH PF17751.1 EMC88828.1 - 4.2e-27 94.7 0.1 9.5e-27 93.6 0.1 1.6 1 0 0 1 1 1 1 SKICH domain Exo_endo_phos PF03372.23 EMC88828.1 - 6.4e-11 42.2 0.0 9.7e-11 41.6 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family HECW_N PF16562.5 EMC88828.1 - 0.096 12.5 0.0 0.27 11.0 0.0 1.8 1 0 0 1 1 1 0 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 DUF1156 PF06634.12 EMC88828.1 - 0.12 12.5 0.0 0.4 10.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1156) Sep15_SelM PF08806.11 EMC88829.1 - 1.9e-11 44.0 0.0 2.5e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 Sep15/SelM redox domain CH PF00307.31 EMC88830.1 - 3.5e-22 78.6 0.0 6.5e-22 77.8 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain Smoothelin PF12510.8 EMC88830.1 - 2e-18 66.2 12.7 6e-18 64.6 12.7 1.9 1 0 0 1 1 1 1 Smoothelin cytoskeleton protein CAMSAP_CH PF11971.8 EMC88830.1 - 1.6e-06 27.8 0.0 3e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 CAMSAP CH domain Peptidase_S64 PF08192.11 EMC88830.1 - 2.4 6.6 16.9 2.7 6.3 16.9 1.1 1 0 0 1 1 1 0 Peptidase family S64 Smoothelin PF12510.8 EMC88831.1 - 7.3e-23 80.4 20.6 4e-18 65.2 8.0 2.3 2 0 0 2 2 2 2 Smoothelin cytoskeleton protein DUF3663 PF12404.8 EMC88831.1 - 0.21 11.7 2.5 0.52 10.4 0.2 2.3 2 1 0 2 2 2 0 Peptidase COQ7 PF03232.13 EMC88831.1 - 0.33 10.7 4.2 0.81 9.4 0.4 2.1 1 1 0 2 2 2 0 Ubiquinone biosynthesis protein COQ7 HATPase_c_3 PF13589.6 EMC88832.1 - 3.1e-26 91.8 0.0 7.9e-26 90.5 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Morc6_S5 PF17942.1 EMC88832.1 - 6.7e-24 84.5 0.6 1.3e-16 60.9 0.0 2.5 2 0 0 2 2 2 2 Morc6 ribosomal protein S5 domain 2-like zf-CW PF07496.15 EMC88832.1 - 9.5e-15 54.4 4.0 2e-14 53.3 4.0 1.6 1 0 0 1 1 1 1 CW-type Zinc Finger Prefoldin_2 PF01920.20 EMC88832.1 - 3.9 7.5 19.6 0.37 10.8 2.3 2.9 2 0 0 2 2 2 0 Prefoldin subunit TMPIT PF07851.13 EMC88832.1 - 3.9 6.6 7.6 13 4.9 1.7 2.6 2 0 0 2 2 2 0 TMPIT-like protein XhlA PF10779.9 EMC88832.1 - 8.8 6.6 16.8 3.1 8.1 0.8 3.8 3 0 0 3 3 3 0 Haemolysin XhlA RhoGAP PF00620.27 EMC88833.1 - 8.2e-35 119.9 0.0 8.9e-35 119.8 0.0 1.0 1 0 0 1 1 1 1 RhoGAP domain Phage_int_SAM_3 PF14659.6 EMC88833.1 - 0.046 14.0 0.0 0.07 13.4 0.0 1.3 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain XFP_C PF09363.10 EMC88833.1 - 0.074 12.5 0.2 0.11 12.0 0.2 1.1 1 0 0 1 1 1 0 XFP C-terminal domain DUF2189 PF09955.9 EMC88834.1 - 0.1 12.8 3.2 0.15 12.3 3.2 1.2 1 1 0 1 1 1 0 Predicted integral membrane protein (DUF2189) Pellino PF04710.14 EMC88835.1 - 1.9e-228 758.0 0.0 2.3e-228 757.8 0.0 1.0 1 0 0 1 1 1 1 Pellino Prok-RING_4 PF14447.6 EMC88835.1 - 0.017 15.0 7.3 1.4 8.9 3.5 3.5 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EMC88835.1 - 0.091 12.6 10.2 1.5 8.8 0.6 3.5 2 2 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC88835.1 - 0.43 10.6 0.1 0.43 10.6 0.1 3.4 2 1 0 2 2 2 0 zinc-RING finger domain zf-RING_2 PF13639.6 EMC88835.1 - 0.7 10.3 10.8 0.67 10.3 0.2 3.1 3 0 0 3 3 3 0 Ring finger domain Vps54 PF07928.12 EMC88836.1 - 4.9e-50 169.4 1.7 6.9e-49 165.7 1.1 2.9 2 0 0 2 2 2 1 Vps54-like protein Vps54_N PF10475.9 EMC88836.1 - 8.7e-08 31.8 7.4 8.7e-08 31.8 7.4 2.6 3 0 0 3 3 3 1 Vacuolar-sorting protein 54, of GARP complex COG2 PF06148.11 EMC88836.1 - 0.28 11.3 4.3 24 5.0 0.0 3.4 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 UDPGP PF01704.18 EMC88837.1 - 5.2e-199 661.1 0.2 6.1e-199 660.8 0.2 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase DUF4301 PF14134.6 EMC88837.1 - 0.054 12.3 0.2 4.9 5.8 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4301) Ldh_1_C PF02866.18 EMC88838.1 - 7.4e-45 152.9 0.1 1.6e-44 151.8 0.0 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EMC88838.1 - 4.9e-40 136.9 0.1 1e-39 135.9 0.1 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Glyco_hydro_3_C PF01915.22 EMC88838.1 - 0.037 14.0 0.1 0.093 12.7 0.0 1.6 1 1 1 2 2 2 0 Glycosyl hydrolase family 3 C-terminal domain Frtz PF11768.8 EMC88839.1 - 5.8e-254 843.5 0.7 6.9e-254 843.2 0.7 1.0 1 0 0 1 1 1 1 WD repeat-containing and planar cell polarity effector protein Fritz NT-C2 PF10358.9 EMC88840.1 - 7.1e-26 90.7 0.4 1.4e-25 89.7 0.4 1.6 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins DUF3585 PF12130.8 EMC88840.1 - 5.6e-23 81.6 11.1 5.6e-23 81.6 11.1 3.5 4 1 0 4 4 4 1 Bivalent Mical/EHBP Rab binding domain CH PF00307.31 EMC88840.1 - 3.2e-22 78.8 0.0 8.4e-22 77.4 0.0 1.8 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EMC88840.1 - 0.00014 21.6 0.0 0.00033 20.4 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain Isochorismatase PF00857.20 EMC88840.1 - 0.092 12.9 0.9 0.23 11.6 0.2 2.0 2 0 0 2 2 2 0 Isochorismatase family DUF4287 PF14117.6 EMC88840.1 - 0.18 11.9 0.1 0.38 10.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4287) Transmemb_17 PF09799.9 EMC88841.1 - 2.5e-30 105.2 14.8 3.3e-30 104.8 14.8 1.2 1 0 0 1 1 1 1 Predicted membrane protein DUF3043 PF11241.8 EMC88841.1 - 0.032 14.3 9.9 0.21 11.6 1.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3043) EGF_CA PF07645.15 EMC88842.1 - 4.7e-10 39.5 6.7 8.5e-10 38.7 6.7 1.4 1 0 0 1 1 1 1 Calcium-binding EGF domain EGF_3 PF12947.7 EMC88842.1 - 3e-05 24.1 4.5 5.5e-05 23.3 4.5 1.4 1 0 0 1 1 1 1 EGF domain EGF_MSP1_1 PF12946.7 EMC88842.1 - 5.9e-05 23.0 3.3 9.5e-05 22.4 3.3 1.4 1 0 0 1 1 1 1 MSP1 EGF domain 1 EGF PF00008.27 EMC88842.1 - 0.0071 16.6 4.1 0.0071 16.6 4.1 2.3 3 0 0 3 3 3 1 EGF-like domain Plasmod_Pvs28 PF06247.11 EMC88842.1 - 0.011 16.0 4.9 0.02 15.2 4.9 1.4 1 0 0 1 1 1 0 Pvs28 EGF domain hEGF PF12661.7 EMC88842.1 - 0.021 15.4 2.0 0.021 15.4 2.0 1.9 2 0 0 2 2 2 0 Human growth factor-like EGF DUF3844 PF12955.7 EMC88842.1 - 0.04 14.0 0.4 0.063 13.4 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3844) FXa_inhibition PF14670.6 EMC88842.1 - 0.36 11.1 5.3 1.9 8.9 5.5 2.0 1 1 1 2 2 2 0 Coagulation Factor Xa inhibitory site Galactosyl_T PF01762.21 EMC88843.1 - 1.5e-42 145.7 0.0 2.4e-42 145.0 0.0 1.3 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 EMC88843.1 - 0.0024 17.4 0.0 0.004 16.6 0.0 1.3 1 0 0 1 1 1 1 Fringe-like DUF604 PF04646.12 EMC88843.1 - 0.0071 15.8 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF604 CDP-OH_P_transf PF01066.21 EMC88844.1 - 2e-12 47.7 0.3 2e-12 47.7 0.3 2.6 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase VIT1 PF01988.19 EMC88844.1 - 1.1 9.0 4.8 0.54 10.1 0.3 2.2 2 1 0 2 2 2 0 VIT family MCM PF00493.23 EMC88845.1 - 1.6e-87 292.3 0.0 2.2e-87 291.8 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 EMC88845.1 - 4.2e-28 97.6 0.4 7.9e-28 96.7 0.4 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_OB PF17207.3 EMC88845.1 - 5.7e-24 84.4 1.6 1.2e-23 83.3 1.6 1.6 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.21 EMC88845.1 - 3.4e-08 33.1 0.0 6.1e-05 22.5 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EMC88845.1 - 1.1e-07 32.0 0.0 3e-07 30.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EMC88845.1 - 0.00021 21.2 0.0 0.00053 19.8 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EMC88845.1 - 0.0061 17.0 1.0 0.046 14.1 0.0 2.7 3 0 0 3 3 3 1 AAA ATPase domain AAA PF00004.29 EMC88845.1 - 0.011 16.1 0.0 0.036 14.5 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 EMC88845.1 - 0.029 14.3 0.0 1.4 8.8 0.0 2.5 2 0 0 2 2 2 0 NTPase FtsK_SpoIIIE PF01580.18 EMC88845.1 - 0.035 13.5 0.0 0.14 11.5 0.0 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_7 PF12775.7 EMC88845.1 - 0.098 12.2 0.0 0.34 10.4 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region MCM_N PF14551.6 EMC88845.1 - 0.14 12.8 0.4 1.2 9.8 0.1 2.4 2 0 0 2 2 2 0 MCM N-terminal domain Gcd10p PF04189.13 EMC88846.1 - 3.1e-65 220.3 2.7 3.1e-65 220.3 2.7 1.9 1 1 1 2 2 2 1 Gcd10p family Goodbye PF17109.5 EMC88846.1 - 2.6 8.5 5.6 2 8.9 0.2 2.7 2 1 1 3 3 3 0 fungal STAND N-terminal Goodbye domain Granin PF01271.17 EMC88847.1 - 1.8e-29 103.2 11.1 2.1e-29 102.9 11.1 1.0 1 0 0 1 1 1 1 Granin (chromogranin or secretogranin) JHD PF17811.1 EMC88847.1 - 0.012 16.2 0.1 0.024 15.2 0.1 1.5 1 0 0 1 1 1 0 Jumonji helical domain STAR_dimer PF16544.5 EMC88847.1 - 0.044 13.4 0.1 0.09 12.4 0.1 1.5 1 0 0 1 1 1 0 Homodimerisation region of STAR domain protein DUF4521 PF15021.6 EMC88848.1 - 2.1e-77 259.7 0.2 2.8e-77 259.2 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4521) Collagen PF01391.18 EMC88849.1 - 1.9e-35 120.4 218.3 6.7e-09 35.4 28.6 8.8 5 2 3 8 8 8 7 Collagen triple helix repeat (20 copies) Fz PF01392.22 EMC88849.1 - 3.1e-19 69.6 0.3 4.7e-19 69.0 0.3 1.3 1 0 0 1 1 1 1 Fz domain Laminin_G_3 PF13385.6 EMC88849.1 - 9.5e-06 25.8 0.0 1.7e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily KH_1 PF00013.29 EMC88850.1 - 3.4e-46 154.9 12.6 4.2e-19 68.1 0.4 3.6 3 1 0 3 3 3 3 KH domain KH_2 PF07650.17 EMC88850.1 - 4.3e-11 42.5 1.5 5.2e-06 26.2 0.0 2.8 3 0 0 3 3 3 2 KH domain KH_4 PF13083.6 EMC88850.1 - 7.9e-06 25.7 1.3 1 9.3 0.0 3.4 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 EMC88850.1 - 0.00032 20.7 3.7 0.32 11.1 0.2 2.7 3 0 0 3 3 3 2 NusA-like KH domain MOEP19 PF16005.5 EMC88850.1 - 0.00052 20.0 0.0 0.023 14.7 0.0 2.4 2 0 0 2 2 2 1 KH-like RNA-binding domain DUF370 PF04025.12 EMC88850.1 - 0.15 12.2 0.5 0.84 9.8 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF370) VWA PF00092.28 EMC88851.1 - 3.9e-87 291.0 4.9 3.5e-30 105.5 0.5 3.1 3 0 0 3 3 3 3 von Willebrand factor type A domain Collagen PF01391.18 EMC88851.1 - 5.6e-52 173.3 210.0 4.7e-10 39.1 22.7 7.3 1 1 5 6 6 6 5 Collagen triple helix repeat (20 copies) VWA_2 PF13519.6 EMC88851.1 - 2.2e-36 124.7 0.6 1.4e-12 48.2 0.0 3.3 3 0 0 3 3 3 3 von Willebrand factor type A domain FTCD_N PF07837.12 EMC88853.1 - 2.3e-72 242.5 0.0 3.8e-72 241.8 0.0 1.4 1 0 0 1 1 1 1 Formiminotransferase domain, N-terminal subdomain FTCD PF02971.14 EMC88853.1 - 1e-69 233.1 0.0 2e-69 232.2 0.0 1.5 1 0 0 1 1 1 1 Formiminotransferase domain FTCD_C PF04961.12 EMC88853.1 - 5.4e-67 225.1 0.5 8.5e-67 224.4 0.5 1.3 1 0 0 1 1 1 1 Formiminotransferase-cyclodeaminase Keratin PF02422.16 EMC88854.1 - 1.2e-31 108.2 11.8 1.4e-31 108.1 11.8 1.0 1 0 0 1 1 1 1 Keratin MCM3AP_GANP PF16769.5 EMC88855.1 - 0 1098.2 6.4 0 1098.2 6.4 1.6 2 0 0 2 2 2 1 MCM3AP domain of GANP SAC3_GANP PF03399.16 EMC88855.1 - 5e-118 393.8 4.2 5e-118 393.8 4.2 1.9 2 0 0 2 2 2 1 SAC3/GANP family CID_GANP PF16766.5 EMC88855.1 - 7.6e-28 96.5 8.2 7.6e-28 96.5 8.2 3.2 2 1 1 3 3 3 1 Binding region of GANP to ENY2 CSN8_PSD8_EIF3K PF10075.9 EMC88855.1 - 1.5e-06 28.2 0.0 4e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family UPF0158 PF03682.13 EMC88855.1 - 0.0062 16.5 0.7 0.017 15.1 0.7 1.7 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0158) RRM_1 PF00076.22 EMC88855.1 - 0.01 15.7 0.0 0.026 14.3 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Tobravirus_2B PF05271.11 EMC88855.1 - 0.078 12.9 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 Tobravirus 2B protein CNOT11 PF10155.9 EMC88855.1 - 0.15 12.2 2.5 0.53 10.5 2.5 1.9 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 11 SAC3 PF12209.8 EMC88855.1 - 0.77 10.0 5.1 1 9.6 1.3 3.1 3 0 0 3 3 3 0 Leucine permease transcriptional regulator helical domain O-FucT PF10250.9 EMC88856.1 - 8.4e-73 246.0 0.0 9.8e-73 245.8 0.0 1.0 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase SNF2_N PF00176.23 EMC88858.1 - 5.2e-22 78.0 0.0 5.9e-22 77.9 0.0 1.0 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 EMC88858.1 - 0.00034 20.6 0.0 0.00038 20.5 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EMC88858.1 - 0.011 16.1 0.1 0.012 15.9 0.1 1.3 1 0 0 1 1 1 0 AAA domain SWI2_SNF2 PF18766.1 EMC88858.1 - 0.066 12.9 0.0 0.067 12.9 0.0 1.1 1 0 0 1 1 1 0 SWI2/SNF2 ATPase DEAD PF00270.29 EMC88858.1 - 0.078 12.7 0.0 0.079 12.7 0.0 1.2 1 0 0 1 1 1 0 DEAD/DEAH box helicase DUF2075 PF09848.9 EMC88858.1 - 0.14 11.4 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 EMC88858.1 - 0.17 12.2 0.0 0.19 12.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain MSSP PF03940.13 EMC88860.1 - 9 6.0 14.4 13 5.4 0.2 3.0 2 1 0 2 2 2 0 Male specific sperm protein DUF1086 PF06461.11 EMC88861.1 - 2.7e-21 75.8 0.0 3.1e-21 75.7 0.0 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) DUF3142 PF11340.8 EMC88862.1 - 0.3 10.9 0.8 1e+02 2.6 0.0 3.8 2 1 2 5 5 5 0 Protein of unknown function (DUF3142) DNA_methylase PF00145.17 EMC88864.1 - 1.1e-15 57.9 0.0 3.9e-11 42.9 0.0 2.2 2 0 0 2 2 2 2 C-5 cytosine-specific DNA methylase PWWP PF00855.17 EMC88864.1 - 3.4e-12 46.6 1.7 6.2e-12 45.8 0.6 1.9 2 0 0 2 2 2 1 PWWP domain GST_C_2 PF13410.6 EMC88865.1 - 1e-05 25.4 0.0 6.1e-05 23.0 0.0 2.3 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EMC88865.1 - 2.2e-05 24.6 0.0 4.1e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EMC88865.1 - 0.0012 19.0 0.0 0.0036 17.5 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain TMPIT PF07851.13 EMC88865.1 - 0.012 14.8 0.1 0.017 14.4 0.1 1.1 1 0 0 1 1 1 0 TMPIT-like protein Nsp1 PF11501.8 EMC88865.1 - 0.16 12.0 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 Non structural protein Nsp1 Scs3p PF10261.9 EMC88866.1 - 4.6e-19 68.9 19.3 9.6e-12 44.9 7.2 2.5 1 1 1 2 2 2 2 Inositol phospholipid synthesis and fat-storage-inducing TM PAP2 PF01569.21 EMC88866.1 - 1.4e-05 24.9 3.3 1.4e-05 24.9 3.3 2.3 1 1 1 2 2 2 1 PAP2 superfamily ARL6IP6 PF15062.6 EMC88866.1 - 0.076 13.1 0.6 0.076 13.1 0.6 2.2 2 1 1 3 3 3 0 Haemopoietic lineage transmembrane helix DHDPS PF00701.22 EMC88866.1 - 0.096 11.4 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Dihydrodipicolinate synthetase family Polysacc_synt PF01943.17 EMC88866.1 - 0.28 10.5 8.1 0.21 11.0 0.5 2.2 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein CAP PF00188.26 EMC88867.1 - 9.6e-25 87.8 4.1 1.2e-24 87.5 4.1 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family CRAL_TRIO PF00650.20 EMC88868.1 - 7.5e-34 116.7 0.0 1e-33 116.3 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EMC88868.1 - 3e-07 30.5 0.5 7.5e-07 29.2 0.5 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EMC88868.1 - 4.5e-06 26.9 0.0 7.3e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Serinc PF03348.15 EMC88869.1 - 2.1e-176 587.1 20.5 2.4e-176 586.9 20.5 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) SHP PF03579.13 EMC88869.1 - 2 8.5 5.5 24 5.0 0.0 3.6 3 0 0 3 3 3 0 Small hydrophobic protein PKI PF02827.16 EMC88870.1 - 8e-19 67.6 0.1 8.4e-19 67.6 0.1 1.0 1 0 0 1 1 1 1 cAMP-dependent protein kinase inhibitor A_deaminase PF00962.22 EMC88871.1 - 1.5e-95 320.3 0.0 1.7e-95 320.1 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase IGFBP PF00219.18 EMC88872.1 - 3e-10 40.6 20.6 3e-10 40.6 20.6 2.7 2 1 0 2 2 2 1 Insulin-like growth factor binding protein VWC PF00093.18 EMC88872.1 - 1.8e-05 24.9 2.6 1.8e-05 24.9 2.6 3.1 3 1 0 3 3 3 1 von Willebrand factor type C domain Secapin PF17521.2 EMC88872.1 - 0.077 12.8 7.7 0.15 11.9 7.7 1.4 1 0 0 1 1 1 0 Honey bee peptides 7tm_1 PF00001.21 EMC88873.1 - 6e-41 140.5 2.0 8e-41 140.1 2.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ion_trans_2 PF07885.16 EMC88874.1 - 2.8e-37 126.5 15.8 1.2e-18 66.8 0.8 2.1 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 EMC88874.1 - 1.3e-05 24.6 14.9 0.0038 16.5 8.0 2.2 1 1 0 2 2 2 2 Ion transport protein IRK PF01007.20 EMC88874.1 - 0.47 10.3 0.1 0.47 10.3 0.1 2.6 2 1 1 3 3 3 0 Inward rectifier potassium channel transmembrane domain Reticulon PF02453.17 EMC88874.1 - 0.53 10.2 4.7 0.9 9.5 1.0 2.2 2 0 0 2 2 2 0 Reticulon DUF2101 PF09874.9 EMC88874.1 - 9.1 5.9 10.3 18 4.9 0.3 2.6 1 1 0 2 2 2 0 Predicted membrane protein (DUF2101) C2 PF00168.30 EMC88875.1 - 2.1e-15 56.8 0.0 3.6e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 C2 domain 14-3-3 PF00244.20 EMC88876.1 - 1.2e-108 361.7 10.4 1.4e-108 361.6 10.4 1.0 1 0 0 1 1 1 1 14-3-3 protein Peptidase_C98 PF15499.6 EMC88876.1 - 0.02 14.4 0.3 0.035 13.6 0.3 1.5 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase FliM PF02154.15 EMC88876.1 - 0.051 13.5 0.2 0.087 12.7 0.2 1.3 1 0 0 1 1 1 0 Flagellar motor switch protein FliM SF3A2 PF16835.5 EMC88876.1 - 0.12 12.8 0.4 0.34 11.3 0.2 1.8 2 0 0 2 2 2 0 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) DUF4518 PF15008.6 EMC88876.1 - 0.14 11.4 5.4 3.2 6.8 5.4 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4518) Virulence_fact PF13769.6 EMC88876.1 - 1.8 8.8 7.7 0.91 9.8 0.7 2.9 2 1 1 3 3 3 0 Virulence factor YabA PF06156.13 EMC88876.1 - 3.2 8.5 6.6 1.2 9.9 2.6 2.2 3 0 0 3 3 3 0 Initiation control protein YabA RRM_1 PF00076.22 EMC88877.1 - 2.5e-86 283.5 0.4 1.5e-20 72.8 0.0 5.3 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EMC88877.1 - 7.5e-29 99.7 0.1 1.7e-28 98.6 0.1 1.6 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain Nup35_RRM_2 PF14605.6 EMC88877.1 - 7.1e-05 22.7 0.5 3.5 7.7 0.0 4.4 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EMC88877.1 - 0.00022 21.3 0.2 12 6.1 0.0 5.0 4 3 0 4 4 4 1 RNA recognition motif RRM_3 PF08777.11 EMC88877.1 - 0.00066 19.7 1.3 1.1 9.4 0.1 3.6 4 0 0 4 4 4 1 RNA binding motif SET_assoc PF11767.8 EMC88877.1 - 0.0012 18.5 0.4 8.8 6.1 0.0 4.1 4 0 0 4 4 4 1 Histone lysine methyltransferase SET associated RRM_occluded PF16842.5 EMC88877.1 - 0.0012 18.6 0.0 8.9 6.3 0.0 4.2 5 0 0 5 5 5 1 Occluded RNA-recognition motif Limkain-b1 PF11608.8 EMC88877.1 - 0.015 15.3 0.8 45 4.2 0.0 4.0 5 0 0 5 5 5 0 Limkain b1 DHHA1 PF02272.19 EMC88877.1 - 0.041 14.3 0.3 7.5 7.0 0.1 3.3 3 1 1 4 4 4 0 DHHA1 domain OB_RNB PF08206.11 EMC88877.1 - 0.078 12.7 4.9 16 5.2 0.2 3.5 3 0 0 3 3 3 0 Ribonuclease B OB domain TPR_1 PF00515.28 EMC88878.1 - 1.6e-25 87.8 12.3 3.5e-10 39.3 0.2 4.3 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 EMC88878.1 - 9.2e-21 72.2 9.9 6.5e-07 29.0 0.1 4.4 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 EMC88878.1 - 7.9e-15 53.8 12.3 5.2e-06 26.3 0.1 4.3 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.6 EMC88878.1 - 7.1e-11 41.6 9.0 4.3e-05 23.1 0.2 3.7 2 1 1 3 3 3 2 TPR repeat TPR_16 PF13432.6 EMC88878.1 - 1.9e-10 41.2 0.0 6.3e-05 23.5 0.0 3.8 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EMC88878.1 - 7.8e-09 35.7 7.6 0.0019 18.5 1.1 3.8 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 EMC88878.1 - 3.2e-08 33.7 5.3 0.0051 17.5 0.1 4.6 2 1 3 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 EMC88878.1 - 1.6e-07 31.2 7.7 0.00013 22.1 0.1 4.3 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 EMC88878.1 - 1.8e-06 28.0 2.1 0.0011 19.1 0.1 3.0 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 EMC88878.1 - 3.9e-06 27.3 6.2 1.8e-05 25.1 2.9 3.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMC88878.1 - 3.4e-05 23.6 4.5 0.72 10.0 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMC88878.1 - 0.00011 22.1 11.1 0.0059 16.6 0.8 3.5 4 1 1 5 5 4 2 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 EMC88878.1 - 0.00033 20.8 6.7 0.00033 20.8 6.7 2.4 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.18 EMC88878.1 - 0.0024 17.9 11.2 2.2 8.4 0.2 4.8 3 2 1 4 4 4 2 MIT (microtubule interacting and transport) domain BTAD PF03704.17 EMC88878.1 - 0.016 15.7 0.6 0.016 15.7 0.6 2.0 2 1 0 2 2 2 0 Bacterial transcriptional activator domain SHNi-TPR PF10516.9 EMC88878.1 - 0.038 13.4 8.0 3.5 7.2 0.1 4.5 5 0 0 5 5 5 0 SHNi-TPR DUF627 PF04781.12 EMC88878.1 - 0.074 13.1 4.4 0.25 11.4 0.9 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF627) TPR_15 PF13429.6 EMC88878.1 - 0.074 12.3 5.8 0.13 11.4 0.7 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMC88878.1 - 0.09 13.5 13.9 0.51 11.1 0.4 4.5 4 2 0 4 4 4 0 Tetratricopeptide repeat GNT-I PF03071.15 EMC88878.1 - 0.1 11.3 0.2 0.14 10.9 0.2 1.2 1 0 0 1 1 1 0 GNT-I family TPR_10 PF13374.6 EMC88878.1 - 2.6 8.1 6.7 1.4 8.9 0.1 3.5 3 1 1 4 4 4 0 Tetratricopeptide repeat Pkinase PF00069.25 EMC88879.1 - 3.6e-69 233.1 0.0 5e-69 232.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC88879.1 - 2.4e-51 174.5 0.0 3.5e-51 174.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC88879.1 - 2.2e-06 26.7 0.0 4.5e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EMC88879.1 - 0.0037 16.2 0.5 0.14 11.1 0.5 2.2 1 1 0 1 1 1 1 Haspin like kinase domain DUF4611 PF15387.6 EMC88879.1 - 0.022 15.0 1.9 0.022 15.0 1.9 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4611) Kinase-like PF14531.6 EMC88879.1 - 0.15 11.3 0.4 1.3 8.3 0.1 2.4 2 1 0 2 2 2 0 Kinase-like Cortexin PF11057.8 EMC88880.1 - 4.2e-40 135.4 0.1 4.8e-40 135.3 0.1 1.1 1 0 0 1 1 1 1 Cortexin of kidney Tim44 PF04280.15 EMC88881.1 - 1.3e-42 145.4 0.2 4.2e-42 143.7 0.0 1.9 2 0 0 2 2 2 1 Tim44-like domain Kinase-PolyVal PF18762.1 EMC88881.1 - 0.033 14.1 0.2 0.068 13.1 0.2 1.4 1 0 0 1 1 1 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins DUF5089 PF17002.5 EMC88881.1 - 0.18 11.6 15.8 6.3 6.6 0.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5089) DUF1931 PF09123.11 EMC88881.1 - 0.2 11.7 2.5 0.72 10.0 0.7 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF1931) DUF3347 PF11827.8 EMC88881.1 - 1.7 8.8 13.0 3.2 7.9 0.7 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3347) Dak2 PF02734.17 EMC88881.1 - 3.2 7.6 6.3 1.7 8.5 1.2 2.3 1 1 0 2 2 2 0 DAK2 domain AIM3 PF17096.5 EMC88881.1 - 6.9 7.7 6.5 0.7 10.9 0.4 2.2 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 RRM_1 PF00076.22 EMC88882.1 - 3.1e-22 78.2 0.1 1.4e-10 40.8 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Collagen_mid PF15984.5 EMC88882.1 - 2e-06 27.7 2.7 4.3e-05 23.4 0.2 2.6 2 1 1 3 3 3 2 Bacterial collagen, middle region DUF1664 PF07889.12 EMC88882.1 - 0.1 12.7 0.0 0.87 9.6 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF572 PF04502.13 EMC88883.1 - 3.3e-97 326.1 22.6 3.7e-97 325.9 22.6 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) Ins_P5_2-kin PF06090.12 EMC88883.1 - 0.026 14.0 1.2 0.024 14.1 1.2 1.1 1 0 0 1 1 1 0 Inositol-pentakisphosphate 2-kinase SpecificRecomb PF10136.9 EMC88883.1 - 2 6.7 5.0 2.2 6.5 5.0 1.0 1 0 0 1 1 1 0 Site-specific recombinase SH2 PF00017.24 EMC88884.1 - 8.8e-16 57.8 0.0 1.2e-15 57.3 0.0 1.2 1 0 0 1 1 1 1 SH2 domain SPRY PF00622.28 EMC88885.1 - 2.6e-10 40.5 0.1 4.7e-10 39.6 0.1 1.5 1 0 0 1 1 1 1 SPRY domain fn3 PF00041.21 EMC88885.1 - 1.5e-07 31.6 0.0 9.5e-07 29.1 0.0 2.3 2 0 0 2 2 2 1 Fibronectin type III domain fn3_4 PF16794.5 EMC88885.1 - 0.067 13.1 0.0 0.18 11.8 0.0 1.8 1 0 0 1 1 1 0 Fibronectin-III type domain OmpH PF03938.14 EMC88885.1 - 1.6 9.0 9.4 2.8 8.3 9.4 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) RAMA PF18755.1 EMC88886.1 - 8e-27 93.8 0.2 1.6e-26 92.8 0.2 1.5 1 0 0 1 1 1 1 Restriction Enzyme Adenine Methylase Associated JAB PF01398.21 EMC88886.1 - 3.4e-09 36.7 0.0 6.3e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 EMC88886.1 - 8.1e-07 28.8 0.0 6e-06 26.0 0.0 2.1 1 1 1 2 2 2 1 Prokaryotic homologs of the JAB domain BAR PF03114.18 EMC88887.1 - 2.1e-41 142.1 8.5 2.5e-41 141.9 8.5 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 EMC88887.1 - 4.6e-15 55.0 0.1 1e-14 53.9 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC88887.1 - 3.5e-14 52.4 0.1 5.6e-14 51.7 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC88887.1 - 1.5e-13 50.2 0.0 3e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain BAR_2 PF10455.9 EMC88887.1 - 2.3e-08 33.5 6.9 3.1e-08 33.1 6.9 1.1 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3 PF16746.5 EMC88887.1 - 0.0043 16.8 4.4 0.011 15.5 4.5 1.6 1 1 0 1 1 1 1 BAR domain of APPL family Prefoldin_3 PF13758.6 EMC88887.1 - 0.042 13.9 1.4 0.071 13.2 1.4 1.3 1 0 0 1 1 1 0 Prefoldin subunit Exonuc_VII_L PF02601.15 EMC88887.1 - 0.54 9.8 3.3 0.68 9.4 3.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Perilipin PF03036.16 EMC88888.1 - 1.2e-158 528.2 16.0 1.4e-158 528.1 16.0 1.0 1 0 0 1 1 1 1 Perilipin family DUF1664 PF07889.12 EMC88888.1 - 0.027 14.5 7.4 1.3 9.0 0.3 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) ApoL PF05461.11 EMC88888.1 - 0.043 13.1 5.5 0.016 14.6 2.0 2.0 2 0 0 2 2 2 0 Apolipoprotein L Spc7 PF08317.11 EMC88888.1 - 0.05 12.5 5.1 0.55 9.1 1.2 2.4 2 0 0 2 2 2 0 Spc7 kinetochore protein ApoLp-III PF07464.11 EMC88888.1 - 0.067 13.3 8.1 0.36 10.9 0.1 3.6 3 3 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Prefoldin_3 PF13758.6 EMC88888.1 - 0.069 13.2 0.6 0.15 12.1 0.3 1.8 2 0 0 2 2 2 0 Prefoldin subunit DUF948 PF06103.11 EMC88888.1 - 1 9.7 7.0 5.2 7.4 0.0 4.3 3 2 1 4 4 4 0 Bacterial protein of unknown function (DUF948) COG2 PF06148.11 EMC88888.1 - 2.6 8.1 6.2 1.6 8.8 0.1 3.4 3 3 2 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 SKA2 PF16740.5 EMC88888.1 - 7 6.5 8.9 1.7 8.5 0.3 2.9 2 1 0 2 2 2 0 Spindle and kinetochore-associated protein 2 GCSF PF16647.5 EMC88888.1 - 7.8 6.3 9.6 1.2 9.0 0.4 3.0 3 0 0 3 3 3 0 Granulocyte colony-stimulating factor LRR_8 PF13855.6 EMC88889.1 - 5.6e-38 128.5 11.9 1e-20 73.3 1.1 3.4 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EMC88889.1 - 9.2e-21 73.6 13.3 2.9e-05 24.3 0.8 4.8 4 1 0 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC88889.1 - 1.3e-09 37.3 19.7 0.55 11.0 0.0 7.8 6 1 1 7 7 7 4 Leucine Rich Repeat LRR_9 PF14580.6 EMC88889.1 - 5.8e-08 32.4 5.6 0.00064 19.3 1.2 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 EMC88889.1 - 1.2e-07 31.2 17.8 1.2 9.4 0.3 7.3 8 0 0 8 8 8 4 Leucine Rich repeat ChuX_HutX PF06228.13 EMC88890.1 - 4.3 7.1 8.6 11 5.7 0.7 2.7 1 1 1 2 2 2 0 Haem utilisation ChuX/HutX DUF758 PF05527.11 EMC88891.1 - 4e-78 261.6 2.9 4.4e-78 261.4 2.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF758) RPAP3_C PF13877.6 EMC88891.1 - 0.015 15.8 0.8 0.038 14.5 0.3 1.8 2 0 0 2 2 2 0 Potential Monad-binding region of RPAP3 Pico_P2B PF01552.17 EMC88891.1 - 0.09 12.9 0.1 0.21 11.8 0.1 1.7 1 0 0 1 1 1 0 Picornavirus 2B protein DEP PF00610.21 EMC88891.1 - 0.1 12.7 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) UPF0556 PF10572.9 EMC88892.1 - 4.2e-66 221.2 0.2 4.6e-66 221.0 0.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0556 Peptidase_C1 PF00112.23 EMC88893.1 - 3.6e-59 200.5 0.1 4.7e-59 200.1 0.1 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EMC88893.1 - 3.9e-15 56.0 0.3 6.4e-15 55.3 0.3 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EMC88893.1 - 0.00012 21.0 0.2 0.16 10.7 0.1 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Styelin PF17562.2 EMC88893.1 - 0.054 13.9 0.1 0.13 12.6 0.1 1.6 1 0 0 1 1 1 0 Styelin DPPIV_N PF00930.21 EMC88894.1 - 3.2e-102 341.9 0.0 4.2e-102 341.5 0.0 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EMC88894.1 - 6.8e-55 185.8 0.0 1.4e-54 184.8 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EMC88894.1 - 1.1e-06 28.4 0.1 2.4e-06 27.3 0.1 1.5 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 EMC88894.1 - 0.0076 16.9 0.0 0.019 15.6 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 EMC88894.1 - 0.012 15.3 0.0 0.027 14.1 0.0 1.5 1 0 0 1 1 1 0 Putative esterase DLH PF01738.18 EMC88894.1 - 0.035 13.7 0.0 0.1 12.1 0.0 1.9 1 1 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 EMC88894.1 - 0.048 13.3 0.9 0.75 9.4 0.1 2.9 3 0 0 3 3 3 0 alpha/beta hydrolase fold DUF4439 PF14530.6 EMC88894.1 - 0.072 13.8 0.0 0.14 12.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4439) Abhydrolase_2 PF02230.16 EMC88894.1 - 0.19 11.5 0.1 24 4.6 0.0 2.5 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase TIR_2 PF13676.6 EMC88895.1 - 2.7e-05 24.8 0.0 4.3e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 TIR domain TIR-like PF10137.9 EMC88895.1 - 0.12 12.3 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain Perilipin PF03036.16 EMC88896.1 - 7e-145 482.9 19.3 1.8e-144 481.6 19.3 1.6 1 1 0 1 1 1 1 Perilipin family MAP65_ASE1 PF03999.12 EMC88896.1 - 0.017 13.9 4.5 0.032 12.9 1.8 2.0 1 1 1 2 2 2 0 Microtubule associated protein (MAP65/ASE1 family) tRNA_bind_3 PF17176.4 EMC88896.1 - 0.06 13.6 1.6 1.9 8.8 0.5 3.3 3 0 0 3 3 3 0 tRNA-binding domain DUF2452 PF10504.9 EMC88896.1 - 0.3 10.6 2.6 2.4 7.6 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2452) zf-HC5HC2H_2 PF13832.6 EMC88897.1 - 3.1e-36 123.9 7.5 3.1e-36 123.9 7.5 2.0 2 0 0 2 2 2 1 PHD-zinc-finger like domain JmjC PF02373.22 EMC88897.1 - 3.7e-34 117.6 1.0 3.7e-33 114.4 1.0 2.4 1 1 0 1 1 1 1 JmjC domain, hydroxylase Tudor_2 PF18104.1 EMC88897.1 - 9.8e-32 108.3 1.8 1.3e-16 59.9 0.4 2.6 2 0 0 2 2 2 2 Jumonji domain-containing protein 2A Tudor domain zf-HC5HC2H PF13771.6 EMC88897.1 - 3.9e-18 65.5 3.5 3.9e-18 65.5 3.5 3.0 2 1 1 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 EMC88897.1 - 1.4e-13 50.1 13.6 2e-13 49.6 6.9 2.9 2 0 0 2 2 2 1 PHD-finger JmjN PF02375.17 EMC88897.1 - 7.1e-13 48.3 0.0 2e-12 46.8 0.0 1.9 1 0 0 1 1 1 1 jmjN domain PHD PF00628.29 EMC88897.1 - 3.9e-06 26.6 20.6 3.9e-05 23.4 2.6 3.4 3 0 0 3 3 3 2 PHD-finger LBR_tudor PF09465.10 EMC88897.1 - 1.2e-05 25.0 0.8 0.21 11.4 0.2 2.6 2 0 0 2 2 2 2 Lamin-B receptor of TUDOR domain DUF4537 PF15057.6 EMC88897.1 - 0.0098 15.9 0.1 0.038 14.0 0.1 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4537) Tudor_3 PF18115.1 EMC88897.1 - 0.011 15.5 0.6 1.1 9.2 0.2 2.5 2 0 0 2 2 2 0 DNA repair protein Crb2 Tudor domain SLX9 PF15341.6 EMC88897.1 - 0.15 12.5 7.7 0.29 11.5 7.7 1.4 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 zf-RING_2 PF13639.6 EMC88898.1 - 1.3e-12 47.9 9.2 3.2e-12 46.6 9.2 1.8 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EMC88898.1 - 1.1e-10 41.6 6.0 3.1e-10 40.2 6.0 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EMC88898.1 - 1.2e-09 37.7 4.8 1.2e-09 37.7 4.8 2.3 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EMC88898.1 - 2.1e-08 33.9 9.3 6.1e-08 32.4 9.3 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC88898.1 - 4.9e-07 29.6 8.6 1.1e-06 28.5 8.6 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EMC88898.1 - 5.6e-07 29.3 9.6 1.6e-06 27.9 9.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC88898.1 - 1.2e-06 28.4 2.0 1.2e-06 28.4 2.0 2.6 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EMC88898.1 - 0.00019 21.2 7.0 0.00043 20.1 7.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EMC88898.1 - 0.00029 20.8 4.0 0.0006 19.8 4.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger PA PF02225.22 EMC88898.1 - 0.00081 19.4 0.0 0.0014 18.6 0.0 1.3 1 0 0 1 1 1 1 PA domain Prok-RING_4 PF14447.6 EMC88898.1 - 0.0016 18.2 8.2 0.06 13.2 3.4 2.6 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 EMC88898.1 - 0.028 14.0 6.4 0.028 14.0 6.4 2.0 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-HC5HC2H_2 PF13832.6 EMC88898.1 - 0.05 13.8 4.5 0.16 12.2 4.5 1.9 1 1 0 1 1 1 0 PHD-zinc-finger like domain FANCL_C PF11793.8 EMC88898.1 - 0.3 11.3 8.2 1.5 9.0 8.2 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain GAGA PF09237.11 EMC88898.1 - 0.31 10.9 2.5 19 5.1 1.6 2.6 2 0 0 2 2 2 0 GAGA factor RINGv PF12906.7 EMC88898.1 - 0.45 10.7 7.9 1.2 9.3 7.9 1.8 1 0 0 1 1 1 0 RING-variant domain PHD PF00628.29 EMC88898.1 - 0.52 10.2 7.9 1.5 8.8 7.9 1.9 1 0 0 1 1 1 0 PHD-finger Zn-C2H2_12 PF18112.1 EMC88898.1 - 1.4 9.5 5.5 10 6.7 0.3 2.5 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-RING-like PF08746.11 EMC88898.1 - 3.6 8.0 8.9 18 5.7 8.4 2.5 1 1 1 2 2 2 0 RING-like domain zf-RING_11 PF17123.5 EMC88899.1 - 2.5e-11 43.1 1.0 2.5e-11 43.1 1.0 2.8 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_2 PF13639.6 EMC88899.1 - 1.9e-09 37.7 7.8 1.9e-09 37.7 7.8 2.9 3 0 0 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.6 EMC88899.1 - 1.7e-05 24.7 2.2 1.7e-05 24.7 2.2 2.6 2 1 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMC88899.1 - 6.8e-05 22.8 6.6 6.8e-05 22.8 6.6 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EMC88899.1 - 9.1e-05 22.2 11.3 0.00012 21.9 7.5 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC88899.1 - 0.00031 20.5 8.3 0.00031 20.5 8.3 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMC88899.1 - 0.0015 18.7 9.0 0.0015 18.7 9.0 2.5 2 1 0 2 2 2 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EMC88899.1 - 0.003 17.4 6.1 0.003 17.4 6.1 2.4 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EMC88899.1 - 0.0041 17.1 5.8 0.0079 16.2 5.1 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EMC88899.1 - 0.013 15.4 5.8 0.013 15.4 5.8 2.5 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Tropomyosin PF00261.20 EMC88900.1 - 3.9e-102 340.7 85.0 1.9e-97 325.3 61.4 2.0 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.7 EMC88900.1 - 8.9e-39 132.9 71.7 8.2e-35 120.1 39.8 3.1 1 1 0 2 2 2 2 Tropomyosin like Laminin_II PF06009.12 EMC88900.1 - 1e-07 32.0 32.5 0.00046 20.2 7.5 3.4 1 1 2 3 3 3 2 Laminin Domain II CLZ PF16526.5 EMC88900.1 - 1e-06 29.0 46.9 1.5e-05 25.2 8.7 5.1 2 2 3 5 5 5 3 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Laminin_I PF06008.14 EMC88900.1 - 3.1e-05 23.8 49.5 0.00013 21.8 13.4 3.2 1 1 2 3 3 3 2 Laminin Domain I ATG16 PF08614.11 EMC88900.1 - 0.00015 22.0 57.0 0.0022 18.3 18.8 3.5 1 1 1 2 2 1 1 Autophagy protein 16 (ATG16) ERM PF00769.19 EMC88900.1 - 0.0027 17.6 67.9 0.26 11.1 23.2 2.7 1 1 1 2 2 2 2 Ezrin/radixin/moesin family BST2 PF16716.5 EMC88900.1 - 0.0027 18.2 8.0 0.0027 18.2 8.0 5.1 1 1 4 5 5 4 1 Bone marrow stromal antigen 2 CENP-F_leu_zip PF10473.9 EMC88900.1 - 0.0029 17.6 64.8 0.016 15.2 30.9 2.5 2 1 0 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_DNA_bd PF12329.8 EMC88900.1 - 0.0044 17.0 14.0 0.0044 17.0 14.0 6.4 1 1 4 6 6 6 3 TATA element modulatory factor 1 DNA binding DUF3450 PF11932.8 EMC88900.1 - 0.0071 15.7 8.0 0.0071 15.7 8.0 3.7 1 1 4 5 5 4 1 Protein of unknown function (DUF3450) AAA_13 PF13166.6 EMC88900.1 - 0.014 14.1 46.8 0.29 9.7 25.8 2.0 1 1 1 2 2 2 0 AAA domain MscS_porin PF12795.7 EMC88900.1 - 0.015 14.8 42.6 0.28 10.7 23.1 3.3 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain XhlA PF10779.9 EMC88900.1 - 0.018 15.2 2.5 0.018 15.2 2.5 6.5 1 1 6 7 7 7 0 Haemolysin XhlA DUF1664 PF07889.12 EMC88900.1 - 0.046 13.8 31.3 0.077 13.0 4.1 3.7 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) Golgin_A5 PF09787.9 EMC88900.1 - 0.05 13.1 52.7 1.9 7.9 26.4 2.6 1 1 2 3 3 3 0 Golgin subfamily A member 5 SNARE PF05739.19 EMC88900.1 - 0.059 13.4 5.3 2.3 8.3 0.1 3.9 3 0 0 3 3 3 0 SNARE domain DHR10 PF18595.1 EMC88900.1 - 0.06 13.4 64.6 0.028 14.5 27.6 3.5 1 1 2 3 3 3 0 Designed helical repeat protein 10 domain DUF745 PF05335.13 EMC88900.1 - 0.075 12.8 45.8 0.91 9.2 7.5 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF745) Lebercilin PF15619.6 EMC88900.1 - 0.076 12.7 59.7 0.11 12.1 16.7 3.5 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease SlyX PF04102.12 EMC88900.1 - 0.13 12.9 44.1 0.2 12.3 1.1 5.6 1 1 4 5 5 5 0 SlyX HrpB7 PF09486.10 EMC88900.1 - 0.18 12.2 50.2 0.075 13.4 13.3 4.4 1 1 4 5 5 5 0 Bacterial type III secretion protein (HrpB7) Spc7 PF08317.11 EMC88900.1 - 0.21 10.5 62.4 0.12 11.2 26.9 2.7 1 1 1 2 2 2 0 Spc7 kinetochore protein Exonuc_VII_L PF02601.15 EMC88900.1 - 0.23 11.0 32.5 2 7.9 15.4 2.2 1 1 1 2 2 2 0 Exonuclease VII, large subunit EzrA PF06160.12 EMC88900.1 - 0.24 9.5 54.3 0.38 8.9 7.5 3.2 1 1 2 3 3 3 0 Septation ring formation regulator, EzrA DUF16 PF01519.16 EMC88900.1 - 0.37 11.3 38.0 0.43 11.1 6.1 4.4 1 1 3 4 4 4 0 Protein of unknown function DUF16 NPV_P10 PF05531.12 EMC88900.1 - 0.47 10.9 19.0 4.1 7.9 2.3 4.5 2 2 2 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF3584 PF12128.8 EMC88900.1 - 0.49 7.9 54.2 0.57 7.6 24.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Fez1 PF06818.15 EMC88900.1 - 0.57 10.6 50.7 18 5.7 26.4 3.0 1 1 2 3 3 3 0 Fez1 FPP PF05911.11 EMC88900.1 - 0.78 7.8 59.0 0.048 11.9 31.2 2.9 1 1 2 3 3 3 0 Filament-like plant protein, long coiled-coil Fib_alpha PF08702.10 EMC88900.1 - 0.92 9.7 31.2 0.33 11.1 7.0 3.3 1 1 2 4 4 4 0 Fibrinogen alpha/beta chain family ADIP PF11559.8 EMC88900.1 - 1.1 9.3 48.5 1.1 9.3 5.7 4.2 1 1 4 5 5 5 0 Afadin- and alpha -actinin-Binding GAS PF13851.6 EMC88900.1 - 1.3 8.3 62.8 0.42 9.9 22.9 3.1 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Flagellin_N PF00669.20 EMC88900.1 - 2.2 8.4 18.8 0.58 10.3 4.2 3.8 1 1 2 4 4 4 0 Bacterial flagellin N-terminal helical region Uds1 PF15456.6 EMC88900.1 - 2.3 8.4 47.7 0.5 10.5 15.1 5.1 1 1 4 5 5 5 0 Up-regulated During Septation DUF1794 PF08768.11 EMC88900.1 - 2.4 8.1 4.8 28 4.6 0.2 2.9 2 2 1 3 3 3 0 Domain of unknown function (DUF1794) FUSC PF04632.12 EMC88900.1 - 2.7 6.4 16.1 4.9 5.6 9.3 2.1 1 1 1 2 2 2 0 Fusaric acid resistance protein family FH2 PF02181.23 EMC88900.1 - 3.2 6.8 38.9 0.18 10.9 8.9 3.2 1 1 2 3 3 3 0 Formin Homology 2 Domain HemX PF04375.14 EMC88900.1 - 3.2 7.0 35.6 1.2 8.4 13.6 3.2 1 1 2 3 3 3 0 HemX, putative uroporphyrinogen-III C-methyltransferase T3SSipB PF16535.5 EMC88900.1 - 3.4 8.1 47.8 23 5.5 6.0 4.5 1 1 3 4 4 4 0 Type III cell invasion protein SipB HOOK PF05622.12 EMC88900.1 - 3.9 5.5 56.7 0.3 9.2 15.3 2.1 1 1 1 2 2 2 0 HOOK protein COG2 PF06148.11 EMC88900.1 - 4.7 7.3 29.8 2.4e+02 1.8 16.6 4.1 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 TTKRSYEDQ PF10212.9 EMC88900.1 - 6.6 5.6 35.7 2 7.3 11.0 2.5 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein DUF4200 PF13863.6 EMC88900.1 - 8.8 6.8 71.2 0.11 12.9 10.0 4.7 1 1 3 4 4 3 0 Domain of unknown function (DUF4200) DUF2721 PF11026.8 EMC88900.1 - 9.4 6.1 6.7 9.2 6.2 0.2 3.1 2 1 2 4 4 3 0 Protein of unknown function (DUF2721) Ras PF00071.22 EMC88901.1 - 7.6e-51 171.9 0.2 9e-51 171.7 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC88901.1 - 4.8e-21 75.2 0.2 9.1e-21 74.3 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC88901.1 - 3e-10 39.8 0.2 3.4e-10 39.7 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC88901.1 - 0.0015 18.1 0.0 0.0017 17.9 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EMC88901.1 - 0.009 15.4 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF3963 PF13124.6 EMC88901.1 - 0.053 13.5 0.4 0.11 12.5 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3963) Crisp PF08562.10 EMC88902.1 - 0.26 11.9 10.4 2.4 8.8 1.0 3.2 1 1 2 3 3 3 0 Crisp DOT1 PF08123.13 EMC88903.1 - 2.3e-83 278.7 0.4 8.4e-83 276.9 0.0 2.0 2 0 0 2 2 2 1 Histone methylation protein DOT1 HALZ PF02183.18 EMC88903.1 - 0.27 11.5 13.1 4.5 7.6 9.9 3.3 1 1 1 2 2 2 0 Homeobox associated leucine zipper DUF2000 PF09391.10 EMC88903.1 - 0.29 11.0 2.4 13 5.7 0.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2000) PH PF00169.29 EMC88904.1 - 3.3e-11 43.6 0.3 1.6e-10 41.4 0.2 1.8 1 1 1 2 2 2 1 PH domain PH_3 PF14593.6 EMC88904.1 - 0.0035 17.4 0.0 0.0053 16.8 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 EMC88904.1 - 0.0072 16.1 0.3 0.013 15.3 0.1 1.5 1 1 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 EMC88904.1 - 0.015 15.5 0.0 0.11 12.7 0.0 1.9 1 1 1 2 2 2 0 Pleckstrin homology domain PH_11 PF15413.6 EMC88904.1 - 0.041 14.3 0.0 0.081 13.4 0.0 1.7 2 0 0 2 2 2 0 Pleckstrin homology domain SIN1_PH PF16979.5 EMC88904.1 - 0.047 14.0 0.1 0.096 13.0 0.1 1.5 1 0 0 1 1 1 0 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology PH_9 PF15410.6 EMC88904.1 - 0.094 13.1 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain PH_16 PF17838.1 EMC88904.1 - 0.13 12.1 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 PH domain SF3A2 PF16835.5 EMC88905.1 - 2.7e-40 136.6 0.2 4.4e-40 135.9 0.2 1.4 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 EMC88905.1 - 3.5e-07 30.4 2.0 3.5e-07 30.4 2.0 1.6 2 0 0 2 2 2 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.9 EMC88905.1 - 0.0035 17.3 0.1 0.0057 16.6 0.1 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein PRP4 PF08799.11 EMC88905.1 - 0.053 13.1 3.2 0.097 12.2 3.2 1.4 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like LPD24 PF18839.1 EMC88905.1 - 0.11 12.7 0.4 30 5.0 0.0 2.7 3 0 0 3 3 3 0 Large polyvalent protein associated domain 24 zf-C2H2_jaz PF12171.8 EMC88905.1 - 5.1 7.5 6.7 10 6.5 5.0 2.3 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding AMH_N PF04709.12 EMC88906.1 - 5.2e-122 407.6 5.0 6.9e-122 407.2 5.0 1.2 1 0 0 1 1 1 1 Anti-Mullerian hormone, N terminal region TGF_beta PF00019.20 EMC88906.1 - 5.8e-17 62.6 0.4 9.3e-17 61.9 0.4 1.3 1 0 0 1 1 1 1 Transforming growth factor beta like domain JSRP PF15312.6 EMC88907.1 - 7.3e-10 38.6 1.4 7.3e-10 38.6 1.4 2.3 2 2 0 2 2 2 1 Junctional sarcoplasmic reticulum protein Pkinase PF00069.25 EMC88908.1 - 0.075 12.4 0.0 1.1 8.6 0.0 2.2 1 1 0 1 1 1 0 Protein kinase domain LRR_8 PF13855.6 EMC88909.1 - 4.1e-56 186.6 59.0 1.4e-12 47.2 4.5 5.9 1 1 7 8 8 8 8 Leucine rich repeat LRR_5 PF13306.6 EMC88909.1 - 5.5e-27 94.3 1.0 7.6e-12 45.3 0.1 2.6 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 EMC88909.1 - 1.8e-17 63.1 27.1 9e-06 26.0 2.0 6.8 4 2 1 7 7 7 6 Leucine Rich repeats (2 copies) I-set PF07679.16 EMC88909.1 - 1.9e-16 59.9 0.0 3e-16 59.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC88909.1 - 1.1e-13 51.5 0.0 2.4e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC88909.1 - 6.3e-10 39.1 0.1 1.4e-09 38.0 0.0 1.6 2 0 0 2 2 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC88909.1 - 2e-07 31.2 0.0 3.8e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.33 EMC88909.1 - 1.3e-06 28.1 29.2 0.38 11.5 0.0 10.7 11 1 0 11 11 10 2 Leucine Rich Repeat LRRNT PF01462.18 EMC88909.1 - 0.0038 16.8 3.5 0.0038 16.8 3.5 3.0 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain V-set PF07686.17 EMC88909.1 - 0.0042 17.2 0.1 0.16 12.2 0.0 2.6 2 1 0 2 2 2 1 Immunoglobulin V-set domain LRR_6 PF13516.6 EMC88909.1 - 0.0051 16.8 22.3 1.5 9.0 0.0 8.4 10 0 0 10 10 10 1 Leucine Rich repeat LRR_9 PF14580.6 EMC88909.1 - 0.016 14.8 12.2 0.12 11.8 4.0 2.9 2 1 1 3 3 3 0 Leucine-rich repeat Ig_6 PF18452.1 EMC88909.1 - 0.021 14.4 0.0 0.052 13.1 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain LRRCT PF01463.24 EMC88909.1 - 0.026 15.1 2.2 0.26 11.9 0.1 3.8 3 1 1 4 4 4 0 Leucine rich repeat C-terminal domain p450 PF00067.22 EMC88911.1 - 1.8e-50 172.1 4.9 4.6e-27 94.9 0.0 3.0 1 1 2 3 3 3 3 Cytochrome P450 Hormone_recep PF00104.30 EMC88912.1 - 1.2e-27 96.9 0.1 4.4e-27 95.0 0.1 1.7 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor PRT_C PF08372.10 EMC88913.1 - 6.3e-08 32.5 0.2 7.1e-08 32.4 0.2 1.1 1 0 0 1 1 1 1 Plant phosphoribosyltransferase C-terminal Lectin_C PF00059.21 EMC88914.1 - 7.6e-21 74.9 0.7 1.3e-20 74.1 0.7 1.4 1 0 0 1 1 1 1 Lectin C-type domain Ldl_recept_a PF00057.18 EMC88914.1 - 8.2e-11 41.9 7.6 8.2e-11 41.9 7.6 3.5 3 0 0 3 3 3 1 Low-density lipoprotein receptor domain class A UL45 PF05473.12 EMC88914.1 - 0.0012 18.5 0.4 0.0028 17.3 0.0 1.7 2 0 0 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like Pkinase PF00069.25 EMC88915.1 - 2.3e-64 217.3 0.0 2.6e-64 217.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC88915.1 - 5.9e-37 127.4 0.0 7.3e-37 127.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EMC88915.1 - 2.3e-09 36.7 0.1 4e-09 35.9 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EMC88915.1 - 0.00015 21.2 0.0 0.00033 20.1 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC88915.1 - 0.0002 20.8 0.0 0.00031 20.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EMC88915.1 - 0.0012 18.4 0.1 0.0018 17.9 0.1 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Homeodomain PF00046.29 EMC88916.1 - 7.3e-23 80.2 4.7 1.2e-22 79.5 4.7 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC88916.1 - 0.0071 16.2 0.1 0.03 14.2 0.1 2.0 2 0 0 2 2 2 1 Homeobox KN domain DUF3437 PF11919.8 EMC88916.1 - 0.17 11.8 1.0 0.72 9.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) TSP_1 PF00090.19 EMC88917.1 - 1.8e-09 37.7 6.8 1.8e-09 37.7 6.8 2.4 3 1 0 3 3 3 1 Thrombospondin type 1 domain Somatomedin_B PF01033.17 EMC88917.1 - 2.5e-05 24.6 20.7 2.5e-05 24.6 20.7 2.9 4 0 0 4 4 4 1 Somatomedin B domain Mito_carr PF00153.27 EMC88918.1 - 4.9e-61 202.7 0.1 3.2e-20 71.8 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein PI3_PI4_kinase PF00454.27 EMC88919.1 - 2.7e-41 142.0 0.4 3.2e-28 99.2 0.4 2.7 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EMC88919.1 - 6.8e-35 120.1 0.0 1.7e-34 118.8 0.0 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Ribosomal_L18_c PF14204.6 EMC88919.1 - 0.14 13.1 0.2 0.34 11.9 0.2 1.7 1 0 0 1 1 1 0 Ribosomal L18 C-terminal region BTB PF00651.31 EMC88921.1 - 1e-26 93.3 0.2 1.5e-26 92.8 0.2 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.26 EMC88921.1 - 1.5e-26 91.3 24.4 7.4e-06 26.1 1.3 5.9 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC88921.1 - 2.5e-23 80.7 22.7 0.00032 21.3 0.5 5.8 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC88921.1 - 2.7e-19 68.7 30.8 5.8e-08 32.8 0.2 7.4 6 1 0 6 6 6 3 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EMC88921.1 - 7e-16 58.0 3.4 0.00027 21.2 0.3 5.9 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC88921.1 - 2.1e-11 43.8 13.3 0.0035 17.7 0.4 5.9 5 0 0 5 5 5 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EMC88921.1 - 3.3e-10 39.7 21.5 0.018 15.0 0.3 5.9 5 1 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 EMC88921.1 - 1.1e-05 26.1 5.6 0.0028 18.3 0.3 4.1 1 1 2 3 3 3 1 Zinc finger C2H2-type, 3 repeats zf-C2H2_11 PF16622.5 EMC88921.1 - 8.6e-05 22.2 16.6 0.23 11.2 0.4 4.6 5 0 0 5 5 4 3 zinc-finger C2H2-type zf-Di19 PF05605.12 EMC88921.1 - 0.00032 20.9 11.4 0.05 13.9 0.6 3.6 2 1 1 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.5 EMC88921.1 - 0.0012 19.1 10.2 9.6 6.6 1.3 4.5 2 1 2 4 4 4 0 C2H2-type zinc ribbon zf_C2H2_ZHX PF18387.1 EMC88921.1 - 0.0017 17.9 4.4 2 8.1 0.0 3.7 3 0 0 3 3 3 1 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_2 PF12756.7 EMC88921.1 - 0.0024 18.2 14.5 7.7 6.9 0.3 5.1 1 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-UBP PF02148.19 EMC88921.1 - 0.0027 18.0 4.8 2.5 8.5 0.1 3.8 2 1 1 3 3 3 2 Zn-finger in ubiquitin-hydrolases and other protein zf-C2HE PF16278.5 EMC88921.1 - 0.0029 18.0 16.2 0.18 12.3 0.4 5.4 1 1 4 5 5 5 1 C2HE / C2H2 / C2HC zinc-binding finger zf_UBZ PF18439.1 EMC88921.1 - 0.033 13.8 10.6 3.2 7.4 0.1 5.2 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger zf-AN1 PF01428.16 EMC88921.1 - 0.048 13.8 10.1 27 5.0 0.1 4.6 4 0 0 4 4 4 0 AN1-like Zinc finger zf-MYST PF17772.1 EMC88921.1 - 0.073 12.7 0.2 12 5.6 0.0 3.5 3 0 0 3 3 3 0 MYST family zinc finger domain GAGA PF09237.11 EMC88921.1 - 0.14 12.0 4.1 1.6 8.6 0.2 3.1 2 1 1 3 3 3 0 GAGA factor zf-H2C2_5 PF13909.6 EMC88921.1 - 0.27 11.0 22.1 4.6 7.1 0.1 5.7 5 0 0 5 5 5 0 C2H2-type zinc-finger domain zf-BED PF02892.15 EMC88921.1 - 0.46 10.6 17.0 2 8.5 3.7 4.9 4 1 1 5 5 4 0 BED zinc finger zinc_ribbon_15 PF17032.5 EMC88921.1 - 0.85 10.4 8.2 4.8 8.0 0.6 3.4 1 1 0 3 3 3 0 zinc-ribbon family C1_1 PF00130.22 EMC88921.1 - 0.91 9.5 7.4 1.1 9.1 1.4 3.4 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) FYVE PF01363.21 EMC88921.1 - 1.1 9.5 9.1 2e+02 2.2 9.1 2.8 1 1 0 1 1 1 0 FYVE zinc finger LIM PF00412.22 EMC88921.1 - 3.2 8.0 13.0 0.24 11.7 0.5 3.8 3 1 1 4 4 2 0 LIM domain zf-HYPF PF07503.12 EMC88921.1 - 3.3 7.6 7.0 17 5.3 0.4 3.3 3 1 0 3 3 3 0 HypF finger zf-RING_5 PF14634.6 EMC88921.1 - 7.5 6.6 8.4 1.1e+02 2.9 0.1 3.6 2 1 0 2 2 2 0 zinc-RING finger domain Zn-ribbon_8 PF09723.10 EMC88921.1 - 8.2 6.6 14.4 3.6 7.8 4.3 4.1 2 1 3 5 5 5 0 Zinc ribbon domain zf-LYAR PF08790.11 EMC88921.1 - 8.7 6.4 11.6 2.2 8.3 0.1 4.5 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger UQ_con PF00179.26 EMC88923.1 - 5.3e-44 149.3 0.4 6e-44 149.1 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EMC88923.1 - 3.7e-05 24.0 0.1 5.1e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 EMC88923.1 - 3.9e-05 23.4 0.0 4.9e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EMC88923.1 - 4.2e-05 23.4 0.1 7.4e-05 22.6 0.1 1.4 1 0 0 1 1 1 1 UEV domain YdjC PF04794.12 EMC88924.1 - 2.8e-34 119.1 0.0 3.3e-34 118.9 0.0 1.0 1 0 0 1 1 1 1 YdjC-like protein MIR PF02815.19 EMC88925.1 - 7.3e-15 55.3 0.0 5.9e-12 45.8 0.0 2.0 1 1 1 2 2 2 2 MIR domain Topoisom_bac PF01131.20 EMC88926.1 - 9.7e-120 400.3 0.0 1.2e-119 400.1 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 EMC88926.1 - 4.9e-19 68.4 0.0 1e-18 67.5 0.0 1.6 1 0 0 1 1 1 1 Toprim domain DUF2204 PF09970.9 EMC88926.1 - 0.15 11.7 0.1 0.94 9.1 0.0 2.0 2 0 0 2 2 2 0 Nucleotidyl transferase of unknown function (DUF2204) PP2C PF00481.21 EMC88927.1 - 1.8e-64 217.9 0.0 2.2e-64 217.6 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EMC88927.1 - 0.0026 17.4 0.4 0.017 14.8 0.4 2.3 1 1 0 1 1 1 1 Protein phosphatase 2C HHH_5 PF14520.6 EMC88927.1 - 0.046 14.3 0.0 0.13 12.9 0.0 1.7 2 0 0 2 2 2 0 Helix-hairpin-helix domain Acetyltransf_1 PF00583.25 EMC88927.1 - 0.15 12.3 0.0 0.32 11.2 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Pkinase PF00069.25 EMC88929.1 - 2.7e-63 213.8 0.1 3.1e-63 213.6 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC88929.1 - 5.9e-32 111.0 0.0 8.4e-32 110.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EMC88929.1 - 0.00086 19.3 0.0 0.0015 18.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EMC88929.1 - 0.0099 14.9 0.2 0.021 13.8 0.2 1.3 1 1 0 1 1 1 1 Haspin like kinase domain Choline_kinase PF01633.20 EMC88929.1 - 0.057 13.0 0.2 0.088 12.4 0.2 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase FTA2 PF13095.6 EMC88929.1 - 0.058 13.0 0.1 0.087 12.4 0.1 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 EMC88929.1 - 0.061 12.6 0.0 0.1 11.9 0.0 1.4 1 1 0 1 1 1 0 Kinase-like Kdo PF06293.14 EMC88929.1 - 0.089 12.1 0.3 0.13 11.6 0.3 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Yippee-Mis18 PF03226.14 EMC88930.1 - 1.1e-12 48.1 0.1 1.3e-12 47.8 0.1 1.2 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 EMC88930.1 - 0.016 15.4 0.2 0.028 14.6 0.2 1.4 1 1 0 1 1 1 0 C-terminal domain of RIG-I Evr1_Alr PF04777.13 EMC88930.1 - 0.057 13.9 2.6 0.43 11.1 2.6 2.0 1 1 0 1 1 1 0 Erv1 / Alr family zf-CHY PF05495.12 EMC88930.1 - 0.076 13.5 6.8 0.27 11.7 6.8 1.9 1 1 0 1 1 1 0 CHY zinc finger Pro_isomerase PF00160.21 EMC88931.1 - 1.1e-51 175.3 0.1 2.1e-51 174.3 0.1 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-NOSIP PF15906.5 EMC88931.1 - 0.00027 21.0 0.0 0.00071 19.7 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein Rtf2 PF04641.12 EMC88931.1 - 0.0013 18.1 0.5 0.0013 18.1 0.5 3.0 2 1 0 2 2 2 1 Rtf2 RING-finger U-box PF04564.15 EMC88931.1 - 0.0014 18.8 0.0 0.0066 16.6 0.0 2.2 2 0 0 2 2 2 1 U-box domain Hira PF07569.11 EMC88932.1 - 4.6e-57 193.3 0.2 1.1e-56 192.1 0.2 1.7 1 0 0 1 1 1 1 TUP1-like enhancer of split WD40 PF00400.32 EMC88932.1 - 2.7e-28 97.6 31.9 2.5e-08 34.4 4.0 8.7 8 1 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC88932.1 - 6.4e-10 39.2 5.0 0.013 15.8 0.0 5.5 4 1 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 EMC88932.1 - 4.9e-08 32.6 0.0 1.2e-07 31.4 0.0 1.7 1 0 0 1 1 1 1 HIRA B motif Ribonuc_red_lgC PF02867.15 EMC88932.1 - 0.027 13.0 0.6 0.04 12.5 0.6 1.2 1 0 0 1 1 1 0 Ribonucleotide reductase, barrel domain TFIIIC_delta PF12657.7 EMC88932.1 - 0.05 13.5 3.1 0.6 10.0 0.1 3.5 3 1 0 3 3 3 0 Transcription factor IIIC subunit delta N-term WD40_like PF17005.5 EMC88932.1 - 0.071 12.4 0.0 0.56 9.5 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain MRP-L28 PF09812.9 EMC88933.1 - 4.4e-51 173.2 9.1 4.8e-51 173.1 9.1 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 DUF4207 PF13904.6 EMC88933.1 - 0.0034 17.1 12.3 0.0043 16.8 12.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4207) DUF4200 PF13863.6 EMC88933.1 - 0.15 12.5 15.9 0.085 13.3 2.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) AAA_13 PF13166.6 EMC88933.1 - 0.55 8.8 4.8 0.64 8.6 4.8 1.0 1 0 0 1 1 1 0 AAA domain DUF3128 PF11326.8 EMC88934.1 - 3.6e-11 43.3 2.6 4.1e-11 43.1 2.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) UFD1 PF03152.14 EMC88935.1 - 6e-80 266.8 0.0 7.3e-80 266.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 CDC48_2 PF02933.17 EMC88935.1 - 0.13 12.0 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), domain 2 CDC45 PF02724.14 EMC88936.1 - 4.5e-158 527.4 18.2 3.2e-121 405.7 10.7 3.0 1 1 1 2 2 2 2 CDC45-like protein UBA2_C PF16195.5 EMC88936.1 - 0.013 16.2 4.3 0.24 12.1 3.4 2.4 2 0 0 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus DUF3848 PF12959.7 EMC88936.1 - 0.044 13.9 0.5 0.31 11.1 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3848) Septin PF00735.18 EMC88937.1 - 2.5e-125 417.4 0.0 3.1e-125 417.1 0.0 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EMC88937.1 - 2.8e-08 33.8 0.0 9.8e-08 32.1 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC88937.1 - 4.8e-06 26.2 0.1 0.0027 17.3 0.0 2.5 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.16 EMC88937.1 - 4.5e-05 22.9 0.9 0.00012 21.5 0.0 2.0 2 0 0 2 2 2 1 AIG1 family RsgA_GTPase PF03193.16 EMC88937.1 - 5.4e-05 23.2 1.4 0.0012 18.8 0.3 2.6 2 1 0 2 2 2 1 RsgA GTPase Ras PF00071.22 EMC88937.1 - 8e-05 22.3 0.0 0.00026 20.6 0.0 1.9 1 1 0 1 1 1 1 Ras family Dynamin_N PF00350.23 EMC88937.1 - 0.00046 20.3 2.8 0.11 12.5 0.0 3.1 3 1 1 4 4 4 2 Dynamin family Roc PF08477.13 EMC88937.1 - 0.0033 17.6 0.0 0.0062 16.7 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 EMC88937.1 - 0.0033 17.7 1.0 0.011 16.0 0.1 2.6 2 2 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EMC88937.1 - 0.0058 17.0 0.0 0.014 15.8 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 EMC88937.1 - 0.0086 15.6 0.1 0.023 14.2 0.0 1.6 2 0 0 2 2 2 1 P-loop containing dynein motor region Gtr1_RagA PF04670.12 EMC88937.1 - 0.01 15.2 0.0 0.056 12.8 0.0 2.1 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region ABC_tran PF00005.27 EMC88937.1 - 0.014 15.9 1.4 0.029 14.9 0.3 2.1 2 1 0 2 2 2 0 ABC transporter AAA_29 PF13555.6 EMC88937.1 - 0.019 14.7 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain G-alpha PF00503.20 EMC88937.1 - 0.057 12.6 0.0 4.5 6.3 0.0 2.4 2 0 0 2 2 2 0 G-protein alpha subunit Sec2p PF06428.11 EMC88937.1 - 0.17 11.9 4.2 0.31 11.0 3.5 1.9 1 1 0 1 1 1 0 GDP/GTP exchange factor Sec2p AAA_28 PF13521.6 EMC88937.1 - 0.47 10.7 2.6 20 5.4 0.0 2.9 3 0 0 3 3 3 0 AAA domain Cpn60_TCP1 PF00118.24 EMC88938.1 - 7.1e-148 493.3 13.4 8.2e-148 493.1 13.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF2529 PF10740.9 EMC88938.1 - 0.0034 17.0 0.2 0.014 15.0 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF2529) Ribosomal_S13 PF00416.22 EMC88938.1 - 0.18 12.2 1.3 0.54 10.7 0.3 2.3 2 0 0 2 2 2 0 Ribosomal protein S13/S18 LRR_4 PF12799.7 EMC88939.1 - 2.1e-15 56.6 22.5 0.00015 22.0 0.1 4.9 4 1 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMC88939.1 - 2e-13 49.9 18.4 2.5e-05 23.9 8.0 4.2 1 1 4 5 5 5 5 Leucine rich repeat LRR_1 PF00560.33 EMC88939.1 - 1.1 10.1 26.8 3 8.7 0.2 7.0 7 1 0 7 7 7 0 Leucine Rich Repeat Asp PF00026.23 EMC88940.1 - 5.7e-115 384.1 0.2 6.6e-115 383.8 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EMC88940.1 - 6.1e-13 49.4 0.9 1.1e-10 42.0 0.9 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.12 EMC88940.1 - 9e-10 38.2 1.3 1.5e-09 37.5 1.3 1.4 1 0 0 1 1 1 1 A1 Propeptide TAXi_C PF14541.6 EMC88940.1 - 0.00013 21.8 0.0 0.00031 20.6 0.0 1.6 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Bestrophin PF01062.21 EMC88941.1 - 1.2e-104 349.9 5.5 1.7e-104 349.4 5.5 1.2 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Autophagy_N PF03986.13 EMC88941.1 - 0.0046 16.9 0.4 0.0085 16.0 0.4 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Sec2p PF06428.11 EMC88942.1 - 1.9e-08 34.2 9.3 1.9e-08 34.2 9.3 2.1 1 1 1 2 2 2 1 GDP/GTP exchange factor Sec2p FAM76 PF16046.5 EMC88942.1 - 0.0037 16.7 3.3 0.0061 15.9 3.3 1.3 1 0 0 1 1 1 1 FAM76 protein T3SSipB PF16535.5 EMC88942.1 - 0.043 14.3 5.5 0.076 13.5 5.5 1.4 1 0 0 1 1 1 0 Type III cell invasion protein SipB UPF0242 PF06785.11 EMC88942.1 - 0.068 13.3 6.3 0.11 12.6 6.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF3584 PF12128.8 EMC88942.1 - 0.087 10.3 7.8 0.13 9.7 7.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Spc7 PF08317.11 EMC88942.1 - 0.091 11.6 8.6 0.15 10.9 8.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein GCN5L1 PF06320.13 EMC88942.1 - 0.11 12.7 4.4 0.22 11.7 4.4 1.5 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) DUF3987 PF13148.6 EMC88942.1 - 0.15 11.0 2.8 0.22 10.5 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) FapA PF03961.13 EMC88942.1 - 0.29 9.7 2.6 0.4 9.2 2.6 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A GAS PF13851.6 EMC88942.1 - 0.3 10.4 10.5 0.54 9.6 10.5 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF5082 PF16888.5 EMC88942.1 - 0.56 10.5 7.9 5.9 7.2 2.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) TPR_MLP1_2 PF07926.12 EMC88942.1 - 0.77 9.8 14.4 1.8 8.6 14.4 1.5 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein TMF_TATA_bd PF12325.8 EMC88942.1 - 0.84 9.9 11.3 2.9 8.1 11.3 1.9 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding CC2-LZ PF16516.5 EMC88942.1 - 1.3 9.4 11.8 1.9 8.9 3.7 2.5 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator PRKG1_interact PF15898.5 EMC88942.1 - 1.6 9.7 9.0 3.8 8.5 9.0 1.6 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain CENP-H PF05837.12 EMC88942.1 - 1.9 8.9 9.5 4.6 7.7 9.5 1.6 1 0 0 1 1 1 0 Centromere protein H (CENP-H) ATG16 PF08614.11 EMC88942.1 - 7 6.8 15.3 3.7 7.7 1.6 2.3 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF4407 PF14362.6 EMC88942.1 - 7.5 5.8 8.1 22 4.3 7.9 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) NOT2_3_5 PF04153.18 EMC88943.1 - 3.2e-32 111.4 0.2 6.1e-32 110.5 0.2 1.5 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family SBDS_C PF09377.10 EMC88944.1 - 9.1e-39 132.1 0.9 1.3e-38 131.6 0.9 1.2 1 0 0 1 1 1 1 SBDS protein C-terminal domain SBDS PF01172.18 EMC88944.1 - 5.2e-19 68.1 0.3 1.1e-18 67.1 0.3 1.6 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Alpha_Helical PF18489.1 EMC88944.1 - 0.029 14.6 0.2 0.069 13.3 0.2 1.6 1 0 0 1 1 1 0 Alpha helical domain 2-Hacid_dh_C PF02826.19 EMC88944.1 - 0.064 12.6 0.1 0.21 10.9 0.0 1.8 2 1 1 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CemA PF03040.14 EMC88944.1 - 0.54 10.1 3.0 0.48 10.3 1.7 1.5 1 1 1 2 2 2 0 CemA family Radical_SAM PF04055.21 EMC88945.1 - 8.6e-29 101.1 0.0 2.1e-28 99.8 0.0 1.7 1 0 0 1 1 1 1 Radical SAM superfamily Wyosine_form PF08608.12 EMC88945.1 - 8.9e-28 96.4 0.1 3.4e-27 94.6 0.0 2.1 2 0 0 2 2 2 1 Wyosine base formation Flavodoxin_1 PF00258.25 EMC88945.1 - 6.9e-22 78.2 0.0 1.4e-21 77.2 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin HAD PF12710.7 EMC88945.1 - 0.017 15.5 0.0 0.37 11.1 0.0 2.7 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Adaptin_binding PF10199.9 EMC88945.1 - 0.023 15.3 0.8 0.055 14.1 0.8 1.7 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 DUF3280 PF11684.8 EMC88945.1 - 0.032 14.7 0.0 0.065 13.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2380) Exo_endo_phos_2 PF14529.6 EMC88946.1 - 4.6e-06 26.5 0.0 9.6e-06 25.4 0.0 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase PDEase_I PF00233.19 EMC88947.1 - 7.1e-51 173.2 0.4 3.4e-46 157.9 0.0 2.5 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase Tsp45I PF06300.12 EMC88947.1 - 0.09 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Tsp45I type II restriction enzyme OATP PF03137.20 EMC88948.1 - 5.8e-59 199.8 16.1 7e-59 199.5 16.1 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Kazal_2 PF07648.15 EMC88948.1 - 7.1e-12 45.3 7.8 7.1e-12 45.3 7.8 2.0 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EMC88948.1 - 0.018 15.1 8.1 0.046 13.7 8.1 1.7 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain OATP PF03137.20 EMC88949.1 - 6.6e-84 282.2 5.3 7.6e-84 281.9 5.3 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 EMC88949.1 - 7e-21 74.5 8.4 8.7e-21 74.2 8.4 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily SNN_linker PF09050.10 EMC88949.1 - 0.19 11.6 0.4 0.43 10.4 0.4 1.6 1 0 0 1 1 1 0 Stannin unstructured linker TLD PF07534.16 EMC88950.1 - 3.7e-27 95.2 0.1 6e-15 55.7 0.0 2.4 2 0 0 2 2 2 2 TLD RabGAP-TBC PF00566.18 EMC88950.1 - 3.6e-24 85.6 0.5 6.5e-24 84.8 0.5 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SNARE PF05739.19 EMC88951.1 - 1.2e-07 31.5 2.5 2.5e-07 30.6 2.5 1.5 1 0 0 1 1 1 1 SNARE domain HD_assoc PF13286.6 EMC88951.1 - 0.022 15.3 0.5 0.57 10.7 0.1 2.5 2 1 0 2 2 2 0 Phosphohydrolase-associated domain DUF4407 PF14362.6 EMC88951.1 - 0.029 13.7 3.1 0.052 12.9 3.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) T2SSF PF00482.23 EMC88951.1 - 0.073 13.0 0.8 0.58 10.1 0.1 2.1 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F Baculo_PEP_C PF04513.12 EMC88951.1 - 0.097 12.7 4.9 0.17 11.9 0.4 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Prominin PF05478.11 EMC88951.1 - 0.14 10.1 5.1 0.31 9.0 5.1 1.7 1 1 0 1 1 1 0 Prominin ApoLp-III PF07464.11 EMC88951.1 - 0.18 11.9 4.3 0.21 11.7 0.3 2.4 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Fusion_gly PF00523.18 EMC88951.1 - 0.22 9.8 4.0 0.27 9.4 2.4 1.8 2 0 0 2 2 2 0 Fusion glycoprotein F0 Sec20 PF03908.13 EMC88951.1 - 0.25 11.3 3.7 0.27 11.2 0.4 2.2 2 0 0 2 2 2 0 Sec20 Synaptobrevin PF00957.21 EMC88951.1 - 0.26 11.1 2.9 0.33 10.8 0.7 2.1 2 0 0 2 2 2 0 Synaptobrevin DUF1664 PF07889.12 EMC88951.1 - 2.6 8.1 5.6 1.6 8.8 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF745 PF05335.13 EMC88951.1 - 3.2 7.5 6.2 13 5.5 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF745) V-SNARE PF05008.15 EMC88951.1 - 6.3 7.3 9.7 1.1 9.7 2.4 2.8 2 2 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus NPV_P10 PF05531.12 EMC88951.1 - 8.7 6.9 9.3 4.1 7.9 2.4 2.8 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein PI3K_1B_p101 PF10486.9 EMC88954.1 - 0 1251.6 5.4 2.7e-204 680.6 0.1 2.0 1 1 1 2 2 2 2 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF2397 PF09660.10 EMC88954.1 - 0.13 11.1 0.1 0.21 10.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2397) ARPC4 PF05856.12 EMC88954.1 - 0.14 11.8 3.6 0.72 9.4 1.7 2.6 3 0 0 3 3 3 0 ARP2/3 complex 20 kDa subunit (ARPC4) PI3K_1B_p101 PF10486.9 EMC88955.1 - 3.2e-14 51.7 0.1 2.2e-12 45.6 0.1 2.0 1 1 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit TnpW PF14202.6 EMC88955.1 - 0.0086 15.9 0.0 0.019 14.8 0.0 1.6 1 0 0 1 1 1 1 Transposon-encoded protein TnpW MFS_1_like PF12832.7 EMC88956.1 - 2.3e-43 148.5 2.8 3.4e-43 148.0 2.8 1.2 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 EMC88956.1 - 1e-11 44.4 32.9 5.2e-11 42.1 20.0 3.2 2 1 1 3 3 3 2 Major Facilitator Superfamily DUF3585 PF12130.8 EMC88957.1 - 8e-22 77.8 14.3 1.2e-21 77.3 14.3 1.2 1 0 0 1 1 1 1 Bivalent Mical/EHBP Rab binding domain Hep_59 PF07052.11 EMC88957.1 - 0.0059 17.3 4.7 0.042 14.6 0.5 2.2 2 0 0 2 2 2 1 Hepatocellular carcinoma-associated antigen 59 NEXCaM_BD PF16644.5 EMC88957.1 - 0.041 14.1 0.9 0.041 14.1 0.9 2.0 2 0 0 2 2 2 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin NACHT PF05729.12 EMC88957.1 - 0.042 13.8 0.3 0.051 13.5 0.3 1.2 1 0 0 1 1 1 0 NACHT domain G_glu_transpept PF01019.21 EMC88957.1 - 0.066 12.0 0.3 0.081 11.7 0.3 1.1 1 0 0 1 1 1 0 Gamma-glutamyltranspeptidase Histone_HNS PF00816.21 EMC88957.1 - 0.17 12.7 5.7 0.37 11.6 5.7 1.6 1 1 0 1 1 1 0 H-NS histone family FlxA PF14282.6 EMC88957.1 - 0.42 10.6 11.7 0.11 12.5 5.4 2.2 2 0 0 2 2 2 0 FlxA-like protein DUF1027 PF06265.11 EMC88957.1 - 0.52 10.3 3.8 0.3 11.1 0.3 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1027) MCM6_C PF18263.1 EMC88957.1 - 1.7 8.9 10.8 0.27 11.5 0.7 2.3 1 1 0 2 2 2 0 MCM6 C-terminal winged-helix domain DUF4200 PF13863.6 EMC88959.1 - 2.7e-21 76.2 31.7 2.7e-21 76.2 31.7 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF4200) I_LWEQ PF01608.17 EMC88959.1 - 1.4 9.2 31.6 1.3 9.2 5.7 2.2 2 0 0 2 2 2 0 I/LWEQ domain UvrD-helicase PF00580.21 EMC88959.1 - 3.3 7.2 21.2 4.6 6.7 21.2 1.1 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain CALCOCO1 PF07888.11 EMC88959.1 - 8.5 5.1 42.6 1.8 7.3 8.0 2.0 1 1 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spc7 PF08317.11 EMC88959.1 - 8.9 5.1 40.1 1.6 7.5 21.6 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein zf-CCHC PF00098.23 EMC88960.1 - 0.00045 20.2 11.9 0.0051 16.8 3.4 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 EMC88960.1 - 1.4 8.8 7.7 1.1 9.1 0.5 2.3 2 0 0 2 2 2 0 Zinc knuckle Pkinase PF00069.25 EMC88961.1 - 1.4e-60 204.9 0.0 1.7e-60 204.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC88961.1 - 7.7e-39 133.5 0.0 9.8e-39 133.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC88961.1 - 5.7e-07 29.1 0.0 8.4e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 EMC88961.1 - 0.00015 21.0 0.1 0.00022 20.4 0.1 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Haspin_kinase PF12330.8 EMC88961.1 - 0.00054 19.0 0.0 0.00082 18.4 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EMC88961.1 - 0.0029 16.5 0.0 0.014 14.2 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase DXP_redisom_C PF08436.12 EMC88961.1 - 0.055 13.6 0.0 4.7 7.4 0.0 2.4 2 0 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain APH PF01636.23 EMC88961.1 - 0.1 12.5 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 EMC88961.1 - 0.16 11.5 0.1 0.26 10.8 0.1 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF3110 PF11360.8 EMC88962.1 - 0.17 12.1 0.5 0.59 10.4 0.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3110) Adaptin_binding PF10199.9 EMC88962.1 - 0.24 12.0 25.1 8.6e+02 0.5 25.1 2.7 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 FMN_dh PF01070.18 EMC88963.1 - 2.7e-136 454.2 0.1 3.1e-136 454.0 0.1 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 EMC88963.1 - 7.9e-07 28.4 1.1 5e-06 25.8 0.4 2.3 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 EMC88963.1 - 6.8e-05 22.2 0.1 0.00011 21.4 0.1 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.14 EMC88963.1 - 0.00026 20.4 0.5 0.33 10.2 0.1 2.6 1 1 1 2 2 2 2 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 EMC88963.1 - 0.00084 18.9 0.2 0.0056 16.2 0.1 2.1 1 1 1 2 2 2 1 Histidine biosynthesis protein NMO PF03060.15 EMC88963.1 - 0.0019 17.7 1.3 0.0052 16.2 1.4 1.6 1 1 0 1 1 1 1 Nitronate monooxygenase DHO_dh PF01180.21 EMC88963.1 - 0.01 15.1 0.1 0.031 13.5 0.0 1.8 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase Dus PF01207.17 EMC88963.1 - 0.011 14.9 0.1 4.1 6.4 0.0 2.3 1 1 1 2 2 2 0 Dihydrouridine synthase (Dus) TMP-TENI PF02581.17 EMC88963.1 - 0.031 13.6 0.6 0.21 10.9 0.0 2.4 3 0 0 3 3 3 0 Thiamine monophosphate synthase G3P_antiterm PF04309.12 EMC88963.1 - 0.14 11.5 0.1 8.4 5.8 0.0 2.4 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator PI-PLC-X PF00388.19 EMC88964.1 - 2e-58 196.1 0.2 7e-58 194.3 0.0 2.1 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EMC88964.1 - 5.6e-40 136.3 1.5 5.6e-40 136.3 1.5 3.8 2 1 0 4 4 4 1 Phosphatidylinositol-specific phospholipase C, Y domain PLC-beta_C PF08703.10 EMC88964.1 - 1.5e-36 126.0 34.2 1.5e-36 126.0 34.2 3.0 3 0 0 3 3 3 1 PLC-beta C terminal PH_14 PF17787.1 EMC88964.1 - 1.7e-15 57.0 0.0 4.6e-15 55.6 0.0 1.8 1 0 0 1 1 1 1 PH domain EF-hand_like PF09279.11 EMC88964.1 - 3.5e-11 43.4 0.0 3.5e-11 43.4 0.0 3.1 2 1 1 3 3 3 1 Phosphoinositide-specific phospholipase C, efhand-like DUF1154 PF06631.11 EMC88964.1 - 9.7e-07 28.7 10.8 9.7e-07 28.7 10.8 3.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1154) DUF4510 PF14971.6 EMC88964.1 - 1.2 9.5 10.1 68 3.8 9.5 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4510) PI-PLC-X PF00388.19 EMC88965.1 - 4e-63 211.3 1.1 9.8e-63 210.1 0.0 2.2 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PH_14 PF17787.1 EMC88965.1 - 6.2e-44 149.0 2.1 1e-43 148.3 0.0 2.4 2 0 0 2 2 2 1 PH domain PI-PLC-Y PF00387.19 EMC88965.1 - 3.3e-42 143.5 0.4 3.3e-42 143.5 0.4 3.9 4 1 0 4 4 4 1 Phosphatidylinositol-specific phospholipase C, Y domain DUF1154 PF06631.11 EMC88965.1 - 2.8e-17 62.4 13.1 2.8e-17 62.4 13.1 3.2 3 0 0 3 3 3 1 Protein of unknown function (DUF1154) EF-hand_like PF09279.11 EMC88965.1 - 7e-14 52.1 1.5 2.6e-13 50.2 0.0 2.8 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.30 EMC88965.1 - 1.7e-08 34.6 0.0 4.7e-08 33.2 0.0 1.8 1 0 0 1 1 1 1 C2 domain EF-hand_7 PF13499.6 EMC88965.1 - 0.043 14.3 0.7 0.18 12.3 0.7 2.2 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 EMC88965.1 - 0.16 12.0 1.0 0.56 10.3 0.6 2.2 2 0 0 2 2 2 0 EF-hand domain BCAS3 PF12490.8 EMC88967.1 - 2e-28 99.5 0.0 3.3e-28 98.9 0.0 1.2 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 3 WD40 PF00400.32 EMC88967.1 - 0.00012 22.8 1.3 0.021 15.7 0.1 3.1 2 0 0 2 2 2 2 WD domain, G-beta repeat PP2C PF00481.21 EMC88968.1 - 7.7e-61 206.0 0.0 1.1e-60 205.4 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C UBA2_C PF16195.5 EMC88968.1 - 0.025 15.3 0.3 0.054 14.2 0.3 1.5 1 0 0 1 1 1 0 SUMO-activating enzyme subunit 2 C-terminus PP2C_2 PF13672.6 EMC88968.1 - 0.15 11.7 0.0 1 9.0 0.0 2.1 2 1 0 2 2 2 0 Protein phosphatase 2C TPR_10 PF13374.6 EMC88969.1 - 8.9e-24 82.6 4.9 1.6e-08 34.2 0.0 7.2 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 EMC88969.1 - 4.1e-23 81.5 21.6 6.3e-10 39.2 0.8 7.1 4 3 3 8 8 8 5 Tetratricopeptide repeat TPR_7 PF13176.6 EMC88969.1 - 1.4e-08 34.2 2.8 0.0019 18.1 0.1 5.8 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMC88969.1 - 5.3e-06 26.0 22.1 0.00039 20.1 0.2 6.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 EMC88969.1 - 8.5e-05 22.4 13.4 8.5 6.8 0.3 7.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMC88969.1 - 0.00012 22.0 17.8 0.046 14.0 0.3 7.0 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EMC88969.1 - 0.0014 18.1 10.5 0.094 12.1 2.1 3.2 1 1 2 3 3 3 2 MalT-like TPR region Carb_anhydrase PF00194.21 EMC88970.1 - 5.8e-89 298.0 0.1 6.7e-89 297.8 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase GSG-1 PF07803.11 EMC88970.1 - 0.0046 16.9 0.0 0.0083 16.0 0.0 1.5 1 0 0 1 1 1 1 GSG1-like protein 7tm_1 PF00001.21 EMC88971.1 - 1.1e-25 90.5 17.4 1.2e-25 90.3 17.4 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2418 PF10332.9 EMC88971.1 - 4.5 7.9 5.7 1.6 9.3 0.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2418) Myosin_head PF00063.21 EMC88972.1 - 2.3e-203 677.2 0.6 3e-203 676.8 0.6 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_16 PF13191.6 EMC88972.1 - 0.00067 20.1 0.2 0.086 13.2 0.0 3.3 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EMC88972.1 - 0.0011 19.3 0.1 0.015 15.6 0.0 2.8 1 1 1 2 2 2 1 AAA domain IQ PF00612.27 EMC88972.1 - 0.0019 17.8 1.0 0.0019 17.8 1.0 3.9 4 0 0 4 4 4 2 IQ calmodulin-binding motif GWT1 PF06423.12 EMC88973.1 - 1.2e-34 119.6 4.7 1.2e-34 119.6 4.7 2.8 3 1 0 3 3 3 1 GWT1 Lig_chan PF00060.26 EMC88973.1 - 6.1 6.7 6.1 1.9 8.3 2.5 2.1 2 0 0 2 2 2 0 Ligand-gated ion channel AP3D1 PF06375.11 EMC88974.1 - 0.13 12.5 10.1 0.55 10.5 0.7 2.7 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 adh_short PF00106.25 EMC88975.1 - 3.2e-32 111.6 0.0 3.8e-32 111.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC88975.1 - 3.7e-30 105.2 0.0 4.2e-30 105.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC88975.1 - 0.0046 16.9 0.0 0.0059 16.5 0.0 1.3 1 1 0 1 1 1 1 KR domain SpoU_methylase PF00588.19 EMC88976.1 - 1.8e-31 109.2 0.0 2.1e-31 109.0 0.0 1.1 1 0 0 1 1 1 1 SpoU rRNA Methylase family DUF4177 PF13783.6 EMC88976.1 - 0.068 13.5 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4177) LIM PF00412.22 EMC88978.1 - 7.2e-33 112.6 17.3 1.2e-16 60.6 0.8 2.3 1 1 1 2 2 2 2 LIM domain Homeodomain PF00046.29 EMC88978.1 - 3.2e-10 39.7 0.1 5.8e-10 38.9 0.1 1.4 1 0 0 1 1 1 1 Homeodomain SpoIIIAH PF12685.7 EMC88978.1 - 2.4 8.0 5.8 3.2 7.5 5.8 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein AATF-Che1 PF13339.6 EMC88979.1 - 1e-41 142.9 1.7 6e-41 140.4 0.4 2.4 2 0 0 2 2 2 1 Apoptosis antagonizing transcription factor TRAUB PF08164.12 EMC88979.1 - 8.7e-28 96.7 0.3 8.7e-28 96.7 0.3 2.3 2 0 0 2 2 2 1 Apoptosis-antagonizing transcription factor, C-terminal DUF4711 PF15829.5 EMC88980.1 - 1.7e-40 139.4 0.2 2e-40 139.1 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4711) Myb_DNA-binding PF00249.31 EMC88981.1 - 2.6e-10 40.3 0.1 6.5e-10 39.0 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM PF04433.17 EMC88981.1 - 3e-08 33.9 0.4 1.8e-07 31.4 0.0 2.4 3 0 0 3 3 3 1 SWIRM domain Myb_DNA-bind_6 PF13921.6 EMC88981.1 - 5e-06 26.7 0.3 5.3e-05 23.4 0.1 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain DSPc PF00782.20 EMC88982.1 - 1.9e-37 128.1 0.0 2.2e-37 127.8 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC88982.1 - 7.5e-05 22.4 0.0 0.0001 21.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EMC88982.1 - 0.00023 21.3 0.0 0.00039 20.6 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate HNF-1B_C PF04812.13 EMC88983.1 - 1.3e-110 368.9 38.8 2.4e-110 368.0 38.8 1.4 1 0 0 1 1 1 1 Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus HNF-1_N PF04814.13 EMC88983.1 - 9.4e-47 160.1 0.1 9.4e-47 160.1 0.1 2.7 3 0 0 3 3 3 1 Hepatocyte nuclear factor 1 (HNF-1), N terminus Homeodomain PF00046.29 EMC88983.1 - 0.00066 19.5 1.4 0.00066 19.5 1.4 2.7 2 1 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 EMC88983.1 - 0.047 13.6 0.0 0.31 11.0 0.0 2.3 2 0 0 2 2 2 0 Homeobox KN domain HTH_5 PF01022.20 EMC88983.1 - 0.53 10.2 2.1 0.86 9.5 0.1 2.3 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family DUF4042 PF13251.6 EMC88984.1 - 2.1e-71 239.4 2.8 4.1e-70 235.2 0.1 3.6 4 0 0 4 4 4 1 Domain of unknown function (DUF4042) HEAT_2 PF13646.6 EMC88984.1 - 3.2e-21 75.5 3.5 2e-06 28.1 0.0 7.1 6 3 1 7 7 6 4 HEAT repeats HEAT PF02985.22 EMC88984.1 - 3e-19 67.4 11.7 0.00037 20.5 0.0 10.1 10 0 0 10 10 9 5 HEAT repeat HEAT_EZ PF13513.6 EMC88984.1 - 2.7e-15 56.5 17.4 3.4e-05 24.2 0.5 9.8 9 2 2 11 11 10 4 HEAT-like repeat Adaptin_N PF01602.20 EMC88984.1 - 2e-06 26.7 0.5 0.085 11.4 0.1 4.5 3 2 0 5 5 5 2 Adaptin N terminal region Cnd1 PF12717.7 EMC88984.1 - 6.2e-06 26.3 0.6 0.046 13.8 0.1 4.5 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 EMC88984.1 - 0.002 18.3 0.4 3.1 8.0 0.0 4.5 4 1 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 EMC88984.1 - 0.0048 16.9 23.5 0.86 9.7 0.1 8.0 8 0 0 8 8 8 1 Armadillo/beta-catenin-like repeat RasGEF_N_2 PF14663.6 EMC88984.1 - 0.026 14.9 0.3 11 6.4 0.1 3.0 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain HEAT_PBS PF03130.16 EMC88984.1 - 0.037 14.7 10.2 3.6 8.5 0.0 6.4 6 0 0 6 6 5 0 PBS lyase HEAT-like repeat FANCI_S2 PF14676.6 EMC88984.1 - 0.041 14.2 0.3 15 5.9 0.1 2.9 2 0 0 2 2 2 0 FANCI solenoid 2 API5 PF05918.11 EMC88984.1 - 0.14 10.9 0.0 4 6.2 0.0 2.9 3 0 0 3 3 3 0 Apoptosis inhibitory protein 5 (API5) Dynein_light PF01221.18 EMC88985.1 - 6.2e-44 148.2 2.1 7.1e-44 148.0 2.1 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Nop PF01798.18 EMC88985.1 - 0.062 12.7 0.0 0.07 12.6 0.0 1.0 1 0 0 1 1 1 0 snoRNA binding domain, fibrillarin AAA_lid_7 PF17867.1 EMC88985.1 - 0.07 13.3 0.1 0.095 12.9 0.1 1.2 1 0 0 1 1 1 0 Midasin AAA lid domain Ectatomin PF06457.11 EMC88985.1 - 0.17 11.9 0.2 0.27 11.2 0.2 1.4 1 0 0 1 1 1 0 Ectatomin Herpes_UL47 PF03362.13 EMC88986.1 - 0.0059 15.4 0.0 0.0069 15.2 0.0 1.1 1 0 0 1 1 1 1 Herpesvirus UL47 protein zf-C2H2 PF00096.26 EMC88987.1 - 6.6e-17 60.9 56.3 0.0024 18.2 2.8 7.1 7 0 0 7 7 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC88987.1 - 1.2e-16 60.0 55.0 0.00039 21.0 1.0 6.9 7 0 0 7 7 6 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC88987.1 - 3.1e-12 46.3 60.2 4.9e-06 26.7 2.6 8.7 9 0 0 9 9 8 4 Zinc-finger double domain Spt20 PF12090.8 EMC88987.1 - 3e-05 23.7 30.2 6.6e-05 22.6 30.2 1.6 1 0 0 1 1 1 1 Spt20 family zf-C2H2_jaz PF12171.8 EMC88987.1 - 0.00013 22.2 23.5 0.18 12.1 0.7 6.5 6 0 0 6 6 5 1 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 EMC88987.1 - 0.0046 17.2 31.9 0.42 10.9 3.2 4.6 3 1 1 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding EIF4E-T PF10477.9 EMC88987.1 - 0.006 15.5 16.0 0.0075 15.2 16.0 1.1 1 0 0 1 1 1 1 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E zf-C2H2_6 PF13912.6 EMC88987.1 - 0.0084 16.1 0.4 0.0084 16.1 0.4 7.7 9 0 0 9 9 6 4 C2H2-type zinc finger DUF2722 PF10846.8 EMC88987.1 - 0.01 14.8 35.9 0.01 14.8 35.9 1.6 2 0 0 2 2 1 0 Protein of unknown function (DUF2722) Suf PF05843.14 EMC88987.1 - 0.016 15.2 11.4 0.03 14.3 11.4 1.5 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) EOS1 PF12326.8 EMC88987.1 - 0.017 15.0 9.3 0.036 14.0 9.3 1.5 1 0 0 1 1 1 0 N-glycosylation protein DDHD PF02862.17 EMC88987.1 - 0.027 14.6 10.2 0.033 14.3 8.6 1.9 2 0 0 2 2 2 0 DDHD domain zf-BED PF02892.15 EMC88987.1 - 0.029 14.4 2.5 0.029 14.4 2.5 6.8 5 2 2 7 7 7 0 BED zinc finger ABC2_membrane_2 PF12679.7 EMC88987.1 - 0.047 13.0 0.3 0.088 12.1 0.3 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein Pinin_SDK_memA PF04696.13 EMC88987.1 - 0.086 12.9 22.8 0.15 12.1 22.8 1.3 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region PAT1 PF09770.9 EMC88987.1 - 0.092 11.0 22.7 0.13 10.5 22.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CPSF100_C PF13299.6 EMC88987.1 - 0.095 12.9 11.0 0.2 11.8 10.3 1.8 2 0 0 2 2 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4192 PF13830.6 EMC88987.1 - 0.12 12.4 1.2 0.18 11.8 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) EPL1 PF10513.9 EMC88987.1 - 0.13 12.7 12.5 0.032 14.6 8.9 1.9 2 0 0 2 2 1 0 Enhancer of polycomb-like zf_C2H2_13 PF18508.1 EMC88987.1 - 0.13 11.9 0.1 0.13 11.9 0.1 3.2 3 0 0 3 3 2 0 Zinc finger domain Band_3_cyto PF07565.13 EMC88987.1 - 0.13 12.0 9.9 0.26 11.1 9.9 1.5 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Exonuc_VII_L PF02601.15 EMC88987.1 - 0.16 11.5 13.1 0.26 10.8 13.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit BolA PF01722.18 EMC88987.1 - 0.17 12.2 4.1 56 4.1 0.1 3.8 3 1 0 3 3 3 0 BolA-like protein FapA PF03961.13 EMC88987.1 - 0.22 10.1 6.9 0.3 9.6 6.9 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A eIF-3_zeta PF05091.12 EMC88987.1 - 0.23 10.4 17.7 0.32 9.9 17.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Folate_carrier PF01770.18 EMC88987.1 - 0.29 9.8 5.3 0.41 9.3 5.3 1.2 1 0 0 1 1 1 0 Reduced folate carrier AUX_IAA PF02309.16 EMC88987.1 - 0.3 10.9 7.7 0.58 10.0 7.7 1.4 1 0 0 1 1 1 0 AUX/IAA family ALMT PF11744.8 EMC88987.1 - 0.31 9.8 12.3 0.47 9.2 12.3 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter SLC12 PF03522.15 EMC88987.1 - 0.33 9.9 12.3 0.45 9.5 12.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 CobT PF06213.12 EMC88987.1 - 0.36 10.2 17.2 0.66 9.3 17.2 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Plasmodium_Vir PF05795.11 EMC88987.1 - 0.43 10.0 9.7 0.78 9.1 9.7 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein NARP1 PF12569.8 EMC88987.1 - 0.43 9.4 11.6 0.59 9.0 11.6 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF4834 PF16118.5 EMC88987.1 - 0.59 11.1 15.7 1.5 9.8 15.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) CSG2 PF16965.5 EMC88987.1 - 0.61 9.0 5.6 0.91 8.4 5.6 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator EMC3_TMCO1 PF01956.16 EMC88987.1 - 0.69 9.6 6.2 1.3 8.7 6.2 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like RR_TM4-6 PF06459.12 EMC88987.1 - 0.69 9.7 13.7 0.67 9.7 12.2 1.7 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Coilin_N PF15862.5 EMC88987.1 - 0.89 9.4 15.3 2 8.2 15.3 1.5 1 0 0 1 1 1 0 Coilin N-terminus SpoIIP PF07454.11 EMC88987.1 - 0.91 8.9 14.3 1.4 8.3 14.3 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.17 EMC88987.1 - 0.96 8.1 16.6 1.5 7.5 16.6 1.2 1 0 0 1 1 1 0 Presenilin AIF_C PF14721.6 EMC88987.1 - 1.2 9.5 9.8 2.3 8.6 9.8 1.6 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term TERB2 PF15101.6 EMC88987.1 - 1.3 9.1 19.4 2.1 8.3 19.4 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 zf-C2H2_2 PF12756.7 EMC88987.1 - 1.4 9.3 0.0 1.4 9.3 0.0 6.5 2 1 3 6 6 5 0 C2H2 type zinc-finger (2 copies) Ctr PF04145.15 EMC88987.1 - 1.5 9.5 6.2 3.4 8.3 6.2 1.7 1 0 0 1 1 1 0 Ctr copper transporter family zf-C2H2_8 PF15909.5 EMC88987.1 - 1.5 9.2 16.8 0.3 11.4 3.3 3.5 2 1 1 3 3 3 0 C2H2-type zinc ribbon Ureide_permease PF07168.11 EMC88987.1 - 1.5 7.5 4.7 2.2 7.0 4.7 1.2 1 0 0 1 1 1 0 Ureide permease Zip PF02535.22 EMC88987.1 - 1.6 7.9 7.1 3 7.0 7.1 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter GREB1 PF15782.5 EMC88987.1 - 2.1 5.4 21.7 3.6 4.6 21.7 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer zf_C2H2_ZHX PF18387.1 EMC88987.1 - 2.7 7.7 14.4 2.5 7.8 0.4 3.7 2 1 2 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain ThiD2 PF17792.1 EMC88987.1 - 2.7 8.5 7.7 5.8 7.4 7.7 1.4 1 0 0 1 1 1 0 ThiD2 family Paramyxo_ncap PF00973.19 EMC88987.1 - 2.8 6.8 11.1 4.2 6.2 11.1 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein FAM176 PF14851.6 EMC88987.1 - 2.9 7.6 11.4 5.3 6.7 11.4 1.4 1 0 0 1 1 1 0 FAM176 family DUF1980 PF09323.10 EMC88987.1 - 2.9 7.8 9.6 6.4 6.7 9.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) XRN_M PF17846.1 EMC88987.1 - 3 6.7 11.5 4.6 6.1 11.5 1.2 1 0 0 1 1 1 0 Xrn1 helical domain DUF4407 PF14362.6 EMC88987.1 - 3.1 7.1 15.7 4.6 6.5 15.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Serinc PF03348.15 EMC88987.1 - 3.6 6.4 11.4 0.78 8.6 7.1 1.8 2 0 0 2 2 2 0 Serine incorporator (Serinc) CLN3 PF02487.17 EMC88987.1 - 3.7 6.5 9.7 5.6 5.9 9.7 1.2 1 0 0 1 1 1 0 CLN3 protein PepSY_TM PF03929.16 EMC88987.1 - 3.8 7.1 6.2 6.8 6.3 6.2 1.4 1 0 0 1 1 1 0 PepSY-associated TM region Kei1 PF08552.11 EMC88987.1 - 4.2 7.2 8.0 9.2 6.1 8.0 1.7 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DZR PF12773.7 EMC88987.1 - 5 7.2 26.3 1.2e+02 2.8 0.2 4.6 2 1 0 2 2 1 0 Double zinc ribbon CCDC53 PF10152.9 EMC88987.1 - 5.7 7.3 17.5 0.23 11.9 10.6 2.1 2 1 0 2 2 2 0 Subunit CCDC53 of WASH complex Peptidase_S49_N PF08496.10 EMC88987.1 - 5.9 6.9 11.7 11 6.0 11.7 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal zf-CHCC PF10276.9 EMC88987.1 - 5.9 7.0 14.4 44 4.2 0.1 5.6 6 0 0 6 6 5 0 Zinc-finger domain Peroxin-13_N PF04088.13 EMC88987.1 - 7.2 6.9 8.9 17 5.7 8.9 1.6 1 0 0 1 1 1 0 Peroxin 13, N-terminal region EIIBC-GUT_N PF03612.14 EMC88987.1 - 7.4 6.3 13.2 14 5.4 13.2 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Membralin PF09746.9 EMC88987.1 - 8.1 5.4 10.2 11 4.9 10.2 1.2 1 0 0 1 1 1 0 Tumour-associated protein XPA_N PF01286.18 EMC88987.1 - 8.2 6.6 18.5 2.1 8.4 0.1 5.4 7 0 0 7 7 5 0 XPA protein N-terminal V_ATPase_I PF01496.19 EMC88987.1 - 9.6 4.0 14.7 13 3.5 14.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family KDGP_aldolase PF07071.11 EMC88989.1 - 0.15 11.9 0.7 0.17 11.7 0.2 1.5 1 1 1 2 2 2 0 KDGP aldolase MRP-S23 PF10484.9 EMC88990.1 - 1.1e-11 45.1 0.0 1.2e-11 45.0 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S23 RRM_1 PF00076.22 EMC88991.1 - 0.27 11.1 0.7 0.39 10.6 0.1 1.6 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TUDOR PF00567.24 EMC88992.1 - 7.5e-20 71.2 0.0 1.2e-19 70.5 0.0 1.3 1 0 0 1 1 1 1 Tudor domain KH_1 PF00013.29 EMC88992.1 - 3.2e-11 42.9 0.0 5.8e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 KH domain KH_4 PF13083.6 EMC88992.1 - 0.01 15.7 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 KH domain Agenet PF05641.12 EMC88992.1 - 0.019 15.4 0.0 0.045 14.2 0.0 1.6 1 0 0 1 1 1 0 Agenet domain Herpes_LMP1 PF05297.11 EMC88992.1 - 0.047 12.9 0.4 0.047 12.9 0.4 1.7 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) WD40 PF00400.32 EMC88994.1 - 4.3e-34 116.0 15.2 6.4e-08 33.1 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC88994.1 - 6.3e-12 45.6 0.3 0.014 15.7 0.0 5.6 3 2 4 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain SOCS_box PF07525.16 EMC88994.1 - 1.3e-09 38.2 0.2 2.4e-09 37.4 0.2 1.4 1 0 0 1 1 1 1 SOCS box Ge1_WD40 PF16529.5 EMC88994.1 - 4e-09 35.9 0.3 0.057 12.4 0.0 4.4 2 2 1 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EMC88994.1 - 1.8e-05 24.7 0.0 0.058 13.3 0.0 2.6 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 EMC88994.1 - 0.0012 18.2 0.0 2 7.7 0.0 3.1 1 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 EMC88994.1 - 0.017 13.8 0.3 0.13 10.8 0.1 2.2 1 1 1 2 2 2 0 Nucleoporin Nup120/160 PD40 PF07676.12 EMC88994.1 - 0.02 14.8 6.2 11 6.1 0.2 5.1 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 EMC88994.1 - 0.021 13.4 0.2 1.7 7.1 0.0 2.1 1 1 1 2 2 2 0 Cytochrome D1 heme domain Pkinase_Tyr PF07714.17 EMC88995.1 - 1e-48 165.9 0.0 1.5e-48 165.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC88995.1 - 9.4e-40 136.6 0.0 1.4e-39 136.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 EMC88995.1 - 2.3e-05 23.9 0.0 3.3e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like C1_1 PF00130.22 EMC88995.1 - 0.0004 20.2 12.2 0.0007 19.4 12.2 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) RIO1 PF01163.22 EMC88995.1 - 0.0021 17.7 0.0 0.0034 17.0 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 EMC88995.1 - 0.022 14.1 0.0 0.035 13.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EMC88995.1 - 0.097 12.3 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EMC88995.1 - 0.099 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-RING-like PF08746.11 EMC88995.1 - 0.12 12.7 11.3 0.25 11.7 11.3 1.5 1 0 0 1 1 1 0 RING-like domain FAM76 PF16046.5 EMC88995.1 - 0.6 9.4 8.4 0.96 8.7 8.4 1.2 1 0 0 1 1 1 0 FAM76 protein Complex1_LYR PF05347.15 EMC88996.1 - 2.8e-15 56.1 0.6 3.1e-15 56.0 0.6 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EMC88996.1 - 0.0004 21.1 0.4 0.00047 20.9 0.4 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 EMC88996.1 - 0.0039 17.8 0.1 0.0044 17.6 0.1 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Pkinase PF00069.25 EMC88997.1 - 3.9e-64 216.6 0.0 6.6e-64 215.8 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC88997.1 - 3.9e-31 108.3 0.0 6.2e-31 107.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EMC88997.1 - 5.4e-05 22.3 0.1 0.00012 21.2 0.0 1.5 2 0 0 2 2 2 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EMC88997.1 - 0.00013 20.9 0.0 0.00021 20.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMC88997.1 - 0.0043 17.0 0.4 0.014 15.3 0.4 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EMC88997.1 - 0.011 15.1 0.0 0.023 14.0 0.0 1.5 1 0 0 1 1 1 0 Kinase-like FTA2 PF13095.6 EMC88997.1 - 0.035 13.7 0.0 0.063 12.9 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 IFT20 PF14931.6 EMC88999.1 - 1.8e-32 112.0 8.5 2e-32 111.8 8.5 1.0 1 0 0 1 1 1 1 Intraflagellar transport complex B, subunit 20 HRDC PF00570.23 EMC88999.1 - 0.018 15.0 1.5 0.025 14.6 1.5 1.2 1 0 0 1 1 1 0 HRDC domain DUF4061 PF13270.6 EMC88999.1 - 0.049 14.0 2.9 0.07 13.5 2.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4061) BTB_2 PF02214.22 EMC89000.1 - 2.1e-20 72.9 0.0 4e-20 72.0 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 EMC89000.1 - 2.8e-06 27.5 0.0 6.1e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 EMC89000.1 - 0.013 15.6 0.0 0.025 14.6 0.0 1.4 1 0 0 1 1 1 0 BTB/POZ domain WD40 PF00400.32 EMC89001.1 - 8.3e-63 206.8 17.9 1.3e-08 35.3 0.6 7.7 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC89001.1 - 2.9e-16 59.5 2.7 0.047 14.0 0.0 5.8 2 2 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMC89001.1 - 1.5e-12 47.0 11.3 0.01 14.5 0.0 6.4 2 2 4 7 7 7 4 Nucleoporin Nup120/160 LisH PF08513.11 EMC89001.1 - 6.5e-09 35.4 0.4 1.6e-08 34.2 0.4 1.7 1 0 0 1 1 1 1 LisH eIF2A PF08662.11 EMC89001.1 - 3.3e-05 23.9 2.6 0.097 12.5 0.1 2.8 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 EMC89001.1 - 4.8e-05 22.3 1.4 0.21 10.3 0.0 4.0 1 1 4 5 5 5 1 Nup133 N terminal like Ge1_WD40 PF16529.5 EMC89001.1 - 0.00035 19.6 8.7 1.3 7.9 0.2 5.1 1 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Pox_A_type_inc PF04508.12 EMC89001.1 - 0.0016 18.2 0.1 0.0037 17.0 0.1 1.6 1 0 0 1 1 1 1 Viral A-type inclusion protein repeat LisH_2 PF16045.5 EMC89001.1 - 0.018 14.1 0.0 0.033 13.2 0.0 1.4 1 0 0 1 1 1 0 LisH Roc PF08477.13 EMC89001.1 - 0.055 13.7 0.8 1.7 8.9 0.0 3.0 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase CCDC92 PF14916.6 EMC89002.1 - 2e-19 69.1 12.6 2e-19 69.1 12.6 2.2 2 1 0 2 2 2 1 Coiled-coil domain of unknown function Calici_MSP PF05752.11 EMC89002.1 - 0.048 13.5 2.9 0.1 12.4 2.9 1.6 1 1 1 2 2 2 0 Calicivirus minor structural protein Cob_adeno_trans PF01923.18 EMC89002.1 - 0.083 13.0 7.8 0.1 12.7 7.8 1.1 1 0 0 1 1 1 0 Cobalamin adenosyltransferase Rootletin PF15035.6 EMC89002.1 - 0.12 12.4 18.2 11 6.0 18.2 2.3 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion TPD52 PF04201.15 EMC89002.1 - 0.83 9.3 18.8 0.12 12.0 8.5 2.2 1 1 1 2 2 2 0 Tumour protein D52 family Atg14 PF10186.9 EMC89002.1 - 0.85 8.6 17.4 1.1 8.3 17.4 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FlxA PF14282.6 EMC89002.1 - 1.6 8.8 15.1 1.7 8.6 5.2 2.4 1 1 1 2 2 2 0 FlxA-like protein DivIC PF04977.15 EMC89002.1 - 5.1 6.9 16.7 6.4 6.6 2.8 3.3 1 1 1 2 2 2 0 Septum formation initiator FlaC_arch PF05377.11 EMC89002.1 - 5.1 7.6 8.4 18 5.8 1.4 3.3 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) WSC PF01822.19 EMC89004.1 - 5.2e-21 74.6 12.2 2e-12 47.1 0.6 2.4 2 0 0 2 2 2 2 WSC domain Sulfotransfer_1 PF00685.27 EMC89004.1 - 2.1e-08 34.0 0.5 3.3e-08 33.3 0.2 1.5 2 0 0 2 2 2 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC89004.1 - 0.0053 17.2 0.0 0.01 16.3 0.0 1.4 1 0 0 1 1 1 1 Sulfotransferase family XAF1_C PF18608.1 EMC89005.1 - 1e-25 89.0 2.2 1e-25 89.0 2.2 3.7 3 1 1 4 4 4 1 XIAP-associated factor 1 C-terminal domain zf_UBZ PF18439.1 EMC89005.1 - 0.021 14.4 34.2 0.058 13.0 2.0 6.4 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger Na_sulph_symp PF00939.19 EMC89006.1 - 4.5e-118 395.3 27.8 5.8e-118 394.9 27.8 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 EMC89006.1 - 1.5e-34 119.6 34.3 6.9e-20 71.4 5.5 3.1 2 1 1 3 3 3 3 Citrate transporter Med31 PF05669.12 EMC89007.1 - 1.1e-40 137.6 11.2 1.6e-40 137.0 11.2 1.2 1 0 0 1 1 1 1 SOH1 DUF953 PF06110.11 EMC89008.1 - 6.7e-26 90.3 0.0 7.4e-26 90.1 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) MNR PF15718.5 EMC89009.1 - 0 1158.0 29.0 0 1155.3 29.0 1.8 1 1 0 1 1 1 1 Protein moonraker CM_2 PF01817.21 EMC89009.1 - 1.8 9.0 5.3 0.99 9.8 1.2 2.8 3 0 0 3 3 3 0 Chorismate mutase type II DDHD PF02862.17 EMC89010.1 - 3.7e-50 171.2 0.0 1.1e-49 169.6 0.0 1.9 1 0 0 1 1 1 1 DDHD domain Acid_phosphat_B PF03767.14 EMC89010.1 - 0.017 14.7 0.0 0.035 13.7 0.0 1.5 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) LNS2 PF08235.13 EMC89010.1 - 0.045 13.2 0.1 0.24 10.8 0.1 2.0 1 1 0 1 1 1 0 LNS2 (Lipin/Ned1/Smp2) JHD PF17811.1 EMC89010.1 - 0.12 12.9 0.0 0.24 12.0 0.0 1.4 1 0 0 1 1 1 0 Jumonji helical domain CH PF00307.31 EMC89011.1 - 4.1e-21 75.2 0.0 5.9e-21 74.7 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EMC89011.1 - 0.00033 20.4 0.1 0.00054 19.7 0.1 1.4 1 0 0 1 1 1 1 CAMSAP CH domain F-box-like PF12937.7 EMC89012.1 - 1.2e-07 31.5 3.0 1.2e-07 31.5 3.0 3.2 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 EMC89012.1 - 8.3e-06 25.5 0.3 8.3e-06 25.5 0.3 2.9 4 0 0 4 4 4 1 F-box domain F-box_5 PF18511.1 EMC89012.1 - 9.9e-05 21.8 1.7 0.00024 20.6 1.7 1.6 1 0 0 1 1 1 1 F-box DCB PF16213.5 EMC89012.1 - 0.0012 18.5 1.5 1.1 8.9 0.6 2.3 2 0 0 2 2 2 2 Dimerisation and cyclophilin-binding domain of Mon2 RCS1 PF07326.11 EMC89013.1 - 1.9e-54 185.1 9.8 2e-54 185.0 9.8 1.0 1 0 0 1 1 1 1 Regulator of chromosome segregation 1 Glyco_transf_22 PF03901.17 EMC89014.1 - 1e-27 97.5 33.2 2.9e-27 95.9 33.2 1.6 1 1 0 1 1 1 1 Alg9-like mannosyltransferase family PMT_2 PF13231.6 EMC89014.1 - 4 7.6 28.0 0.24 11.6 13.4 3.5 2 1 2 4 4 4 0 Dolichyl-phosphate-mannose-protein mannosyltransferase zf-BED PF02892.15 EMC89015.1 - 1.2e-63 210.9 29.5 1.8e-16 59.9 0.4 4.7 4 0 0 4 4 4 4 BED zinc finger Dimer_Tnp_hAT PF05699.14 EMC89015.1 - 9.8e-12 44.5 1.7 2.6e-11 43.1 0.6 2.5 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region PyrI_C PF02748.15 EMC89015.1 - 6.9e-05 22.7 5.0 2.5 8.1 0.1 4.5 4 0 0 4 4 4 3 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_12 PF18658.1 EMC89015.1 - 0.19 11.3 12.1 1.1 8.8 0.1 4.3 4 0 0 4 4 4 0 Zinc-finger C2H2-type zinc_ribbon_9 PF14369.6 EMC89015.1 - 5.8 7.3 9.1 41 4.6 0.0 3.9 4 0 0 4 4 4 0 zinc-ribbon TAFA PF12020.8 EMC89018.1 - 7.4e-23 80.8 1.3 8.8e-23 80.6 1.3 1.1 1 0 0 1 1 1 1 TAFA family RabGAP-TBC PF00566.18 EMC89019.1 - 1.8e-50 171.6 1.6 1.8e-50 171.6 1.6 1.7 2 0 0 2 2 2 1 Rab-GTPase-TBC domain ELMO_CED12 PF04727.13 EMC89019.1 - 0.052 13.7 0.1 0.13 12.4 0.1 1.9 1 1 0 1 1 1 0 ELMO/CED-12 family DAGK_cat PF00781.24 EMC89020.1 - 3.3e-26 91.4 0.0 5.4e-26 90.7 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain REPA_OB_2 PF16900.5 EMC89022.1 - 3.4e-08 33.3 0.4 3.4e-08 33.3 0.4 2.2 2 1 0 2 2 2 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 EMC89022.1 - 2.7e-06 27.3 0.0 0.0004 20.3 0.0 2.2 2 0 0 2 2 2 2 OB-fold nucleic acid binding domain aGPT-Pplase2 PF18724.1 EMC89022.1 - 0.05 13.4 0.1 0.069 12.9 0.1 1.3 1 0 0 1 1 1 0 Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 2 ICL PF00463.21 EMC89022.1 - 0.061 11.8 0.3 0.069 11.6 0.3 1.1 1 0 0 1 1 1 0 Isocitrate lyase family Rota_VP4_MID PF17477.2 EMC89022.1 - 0.079 12.3 0.8 0.11 11.9 0.8 1.1 1 0 0 1 1 1 0 Rotavirus VP4 membrane interaction domain zf-H2C2_2 PF13465.6 EMC89023.1 - 8.2e-51 168.3 70.7 9.7e-08 32.1 0.8 10.5 11 0 0 11 11 10 10 Zinc-finger double domain zf-C2H2 PF00096.26 EMC89023.1 - 2.8e-43 144.0 80.7 4.9e-06 26.7 0.3 10.1 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC89023.1 - 7.6e-30 101.0 65.2 0.00071 20.2 0.6 10.1 10 0 0 10 10 10 10 C2H2-type zinc finger zf-LYAR PF08790.11 EMC89023.1 - 2.6e-15 56.0 54.9 0.1 12.5 1.4 10.0 10 0 0 10 10 10 8 LYAR-type C2HC zinc finger LIM PF00412.22 EMC89023.1 - 4.6e-07 30.0 49.5 0.18 12.1 2.4 8.6 2 1 6 9 9 9 3 LIM domain zf-trcl PF13451.6 EMC89023.1 - 1.3e-06 28.2 46.3 0.51 10.3 0.1 10.0 10 0 0 10 10 10 3 Probable zinc-ribbon domain zf_UBZ PF18439.1 EMC89023.1 - 0.00012 21.5 35.9 3.2 7.4 0.1 10.0 10 0 0 10 10 10 1 Ubiquitin-Binding Zinc Finger zf-C2H2_jaz PF12171.8 EMC89023.1 - 0.00084 19.6 42.4 0.1 12.9 0.3 9.0 10 0 0 10 10 10 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMC89023.1 - 0.00089 19.2 0.5 0.00089 19.2 0.5 10.2 10 0 0 10 10 10 1 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 EMC89023.1 - 0.0027 17.8 45.5 0.14 12.3 1.3 7.8 3 1 7 10 10 10 4 Zinc ribbon domain zf-AN1 PF01428.16 EMC89023.1 - 0.01 16.0 60.0 2 8.6 0.1 10.3 7 3 3 10 10 10 0 AN1-like Zinc finger zf-CHY PF05495.12 EMC89023.1 - 0.023 15.2 47.2 1.2 9.7 2.3 5.9 1 1 4 5 5 5 0 CHY zinc finger DUF3268 PF11672.8 EMC89023.1 - 0.028 14.7 14.5 1.8 8.9 0.2 4.7 4 1 1 5 5 5 0 zinc-finger-containing domain zf-C2HE PF16278.5 EMC89023.1 - 0.052 14.0 58.2 1.1 9.8 1.1 9.9 2 2 7 9 9 9 0 C2HE / C2H2 / C2HC zinc-binding finger BHD_1 PF10403.9 EMC89023.1 - 0.071 13.0 0.1 10 6.1 0.0 3.5 4 0 0 4 4 4 0 Rad4 beta-hairpin domain 1 zf-C2HC_2 PF13913.6 EMC89023.1 - 0.076 12.9 0.4 0.076 12.9 0.4 8.4 10 0 0 10 10 10 0 zinc-finger of a C2HC-type SAS4 PF15460.6 EMC89023.1 - 0.082 13.0 0.3 20 5.4 0.0 3.5 2 1 0 2 2 2 0 Something about silencing, SAS, complex subunit 4 zinc_ribbon_15 PF17032.5 EMC89023.1 - 0.096 13.5 35.8 4.2 8.2 3.9 5.6 1 1 5 6 6 6 0 zinc-ribbon family zf-C2H2_11 PF16622.5 EMC89023.1 - 0.27 11.0 0.0 0.27 11.0 0.0 7.8 12 1 0 12 12 10 0 zinc-finger C2H2-type BolA PF01722.18 EMC89023.1 - 0.37 11.1 13.7 2.9 8.2 0.4 5.2 2 1 5 7 7 7 0 BolA-like protein zinc_ribbon_6 PF14599.6 EMC89023.1 - 0.46 10.5 44.3 0.69 10.0 2.0 8.2 3 2 5 8 8 8 0 Zinc-ribbon CpXC PF14353.6 EMC89023.1 - 0.51 10.4 36.2 3.8 7.6 0.4 8.3 1 1 4 5 5 5 0 CpXC protein Evr1_Alr PF04777.13 EMC89023.1 - 0.6 10.6 39.8 2 8.9 0.8 7.8 1 1 7 8 8 8 0 Erv1 / Alr family zf_C2H2_ZHX PF18387.1 EMC89023.1 - 0.78 9.4 43.2 0.22 11.2 1.5 7.5 2 1 3 7 7 7 0 Zinc-fingers and homeoboxes C2H2 finger domain zinc_ribbon_9 PF14369.6 EMC89023.1 - 5.5 7.3 33.3 11 6.3 0.0 8.8 9 0 0 9 9 9 0 zinc-ribbon DUF899 PF05988.12 EMC89023.1 - 5.7 6.4 11.8 8.9 5.8 1.0 3.7 1 1 4 5 5 5 0 Bacterial protein of unknown function (DUF899) MSG PF02349.15 EMC89025.1 - 1.2e-05 25.4 27.4 0.31 11.2 1.7 5.4 1 1 6 7 7 7 7 Major surface glycoprotein Herpes_BLLF1 PF05109.13 EMC89025.1 - 6.4e-05 21.2 0.5 7.7e-05 20.9 0.5 1.1 1 0 0 1 1 1 1 Herpes virus major outer envelope glycoprotein (BLLF1) Pyr_redox_dim PF02852.22 EMC89025.1 - 0.00058 20.1 0.2 1.2e+02 2.9 0.0 5.7 6 1 0 7 7 7 0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain YL1_C PF08265.11 EMC89025.1 - 6.2 6.7 23.3 24 4.8 0.1 7.4 3 2 8 11 11 11 0 YL1 nuclear protein C-terminal domain UQ_con PF00179.26 EMC89027.1 - 6.9e-30 103.5 0.3 8.7e-30 103.2 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Nrap_D4 PF17405.2 EMC89028.1 - 1.1e-54 185.1 0.0 2e-54 184.2 0.0 1.4 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D5 PF17406.2 EMC89028.1 - 7.2e-52 175.4 0.8 9.9e-51 171.7 0.2 2.4 2 0 0 2 2 2 1 Nrap protein PAP/OAS1-like domain 5 Nrap PF03813.14 EMC89028.1 - 1e-47 162.0 0.0 2.8e-47 160.6 0.1 1.7 2 0 0 2 2 2 1 Nrap protein domain 1 Nrap_D2 PF17403.2 EMC89028.1 - 4.7e-44 149.8 1.1 2.3e-41 141.1 0.2 2.4 2 0 0 2 2 2 2 Nrap protein PAP/OAS-like domain Nrap_D3 PF17404.2 EMC89028.1 - 1.4e-40 139.0 0.0 2.4e-40 138.2 0.0 1.4 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D6 PF17407.2 EMC89028.1 - 1.9e-32 112.3 0.0 4.3e-32 111.2 0.0 1.7 1 0 0 1 1 1 1 Nrap protein domain 6 NTP_transf_2 PF01909.23 EMC89028.1 - 0.16 12.3 0.0 0.38 11.1 0.0 1.6 1 0 0 1 1 1 0 Nucleotidyltransferase domain MIP PF00230.20 EMC89029.1 - 1.2e-52 178.9 11.6 1.4e-52 178.6 11.6 1.0 1 0 0 1 1 1 1 Major intrinsic protein CPP1-like PF11833.8 EMC89029.1 - 9.1 5.9 7.1 35 4.0 0.0 2.7 3 1 0 3 3 3 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like PLA2_inh PF02988.15 EMC89030.1 - 3.9e-20 72.3 21.4 1.1e-17 64.4 9.4 2.1 2 0 0 2 2 2 2 Phospholipase A2 inhibitor UPAR_LY6 PF00021.21 EMC89030.1 - 1.4e-10 41.7 22.9 5.6e-07 30.2 5.1 2.2 2 0 0 2 2 2 2 u-PAR/Ly-6 domain MIP PF00230.20 EMC89031.1 - 1.2e-45 156.0 12.0 1.5e-45 155.7 12.0 1.0 1 0 0 1 1 1 1 Major intrinsic protein DUF3172 PF11371.8 EMC89031.1 - 0.15 11.7 0.7 0.32 10.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3172) SMI1_KNR4 PF09346.10 EMC89032.1 - 0.066 13.6 0.1 0.11 12.9 0.1 1.4 1 1 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) KIAA1328 PF15369.6 EMC89033.1 - 1e-141 472.5 39.2 1.3e-141 472.2 39.2 1.1 1 0 0 1 1 1 1 Uncharacterised protein KIAA1328 ERM PF00769.19 EMC89033.1 - 0.0044 16.9 10.1 0.0044 16.9 10.1 2.3 2 1 0 2 2 2 1 Ezrin/radixin/moesin family APG6_N PF17675.1 EMC89033.1 - 3.1 8.3 30.9 0.22 12.1 3.9 2.6 2 1 0 2 2 2 0 Apg6 coiled-coil region RRM_1 PF00076.22 EMC89034.1 - 2.7e-37 126.4 0.0 1.5e-17 63.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMC89034.1 - 0.00038 20.0 0.0 0.26 10.9 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EMC89034.1 - 0.0036 17.3 0.0 0.14 12.1 0.0 2.9 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RNA_bind PF08675.11 EMC89034.1 - 0.012 15.6 0.0 1.8 8.6 0.0 3.0 2 1 0 2 2 2 0 RNA binding domain RRM_3 PF08777.11 EMC89034.1 - 0.024 14.7 0.0 5.6 7.1 0.0 2.4 2 0 0 2 2 2 0 RNA binding motif RRM_7 PF16367.5 EMC89034.1 - 0.03 14.4 0.0 11 6.2 0.0 2.8 2 1 0 2 2 2 0 RNA recognition motif PHM7_cyt PF14703.6 EMC89034.1 - 0.25 11.5 1.0 17 5.6 0.1 2.9 2 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter TF_Otx PF03529.13 EMC89034.1 - 0.37 11.2 15.0 0.26 11.7 3.6 2.5 2 0 0 2 2 2 0 Otx1 transcription factor RRM_1 PF00076.22 EMC89035.1 - 0.026 14.4 0.0 0.046 13.5 0.0 1.5 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CDC37_C PF08564.10 EMC89036.1 - 6.1e-17 61.6 0.0 6.1e-17 61.6 0.0 2.9 2 1 1 3 3 3 1 Cdc37 C terminal domain CDC37_M PF08565.11 EMC89036.1 - 4.7e-09 36.2 0.1 1.6e-07 31.2 0.0 2.7 1 1 1 2 2 2 1 Cdc37 Hsp90 binding domain MRP-S22 PF10245.9 EMC89036.1 - 0.16 11.7 0.9 0.25 11.1 0.1 1.7 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S22 PDEase_I PF00233.19 EMC89038.1 - 1.2e-41 143.0 0.2 1.3e-41 142.9 0.2 1.0 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Kelch_1 PF01344.25 EMC89039.1 - 2.1e-37 126.4 5.4 3.9e-15 55.2 0.2 4.3 4 0 0 4 4 4 4 Kelch motif BACK PF07707.15 EMC89039.1 - 4.7e-33 113.4 1.3 4.7e-33 113.4 1.3 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 EMC89039.1 - 2.5e-26 92.1 0.0 4.5e-26 91.3 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.6 EMC89039.1 - 6.6e-23 80.2 2.8 1.5e-08 34.6 0.0 4.4 1 1 3 4 4 4 3 Kelch motif Kelch_4 PF13418.6 EMC89039.1 - 1.2e-09 38.0 2.3 0.032 14.3 0.1 3.6 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.15 EMC89039.1 - 6.9e-09 35.3 0.7 0.039 14.0 0.0 4.4 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 EMC89039.1 - 2.2e-07 31.0 6.5 0.011 16.0 0.1 3.8 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC89039.1 - 0.096 12.7 0.1 0.096 12.7 0.1 3.2 4 0 0 4 4 4 0 Kelch motif Galactosyl_T PF01762.21 EMC89040.1 - 1.1e-45 155.9 0.0 1.2e-28 100.3 0.0 2.0 1 1 1 2 2 2 2 Galactosyltransferase Chalcone PF02431.15 EMC89040.1 - 0.049 13.0 0.0 0.073 12.5 0.0 1.2 1 0 0 1 1 1 0 Chalcone-flavanone isomerase rRNA_processing PF08524.11 EMC89042.1 - 3e-09 37.0 23.8 3.5e-08 33.6 23.8 2.2 1 1 0 1 1 1 1 rRNA processing Arrestin_C PF02752.22 EMC89043.1 - 1.6e-22 80.4 0.1 1.4e-20 74.1 0.0 2.2 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EMC89043.1 - 5.9e-14 52.3 0.1 4e-13 49.6 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 EMC89043.1 - 0.075 12.7 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 Arrestin_N terminal like 7tm_1 PF00001.21 EMC89044.1 - 1e-33 116.8 18.1 1.2e-33 116.6 18.1 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Lectin_N PF03954.14 EMC89044.1 - 0.099 12.4 0.2 0.2 11.4 0.2 1.5 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain HIG_1_N PF04588.13 EMC89044.1 - 0.17 12.2 0.8 0.49 10.6 0.8 1.8 1 1 0 1 1 1 0 Hypoxia induced protein conserved region DUF3671 PF12420.8 EMC89044.1 - 0.37 10.9 11.9 1.3 9.2 3.2 2.6 2 1 1 3 3 3 0 Protein of unknown function DUF4648 PF15505.6 EMC89045.1 - 0.47 11.3 4.4 2 9.3 0.4 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4648) AMP-binding PF00501.28 EMC89046.1 - 8.2e-92 308.0 0.8 2e-65 221.0 0.1 2.4 2 0 0 2 2 2 2 AMP-binding enzyme DMAP_binding PF06464.11 EMC89046.1 - 4.8e-25 88.5 0.7 9.8e-25 87.5 0.7 1.5 1 0 0 1 1 1 1 DMAP1-binding Domain AMP-binding_C PF13193.6 EMC89046.1 - 0.25 12.4 1.2 1 10.4 1.2 2.1 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain S_100 PF01023.19 EMC89047.1 - 1.3e-20 72.8 0.8 1.9e-20 72.3 0.8 1.3 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.6 EMC89047.1 - 6.6e-05 23.3 1.9 0.00015 22.1 1.9 1.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EMC89047.1 - 0.00024 20.4 2.3 0.0004 19.7 0.3 2.4 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 EMC89047.1 - 0.014 15.3 0.4 1.3 9.2 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain EF-hand_4 PF12763.7 EMC89047.1 - 0.023 14.6 0.8 0.031 14.2 0.8 1.3 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand SQHop_cyclase_C PF13243.6 EMC89048.1 - 3.7e-48 164.3 0.0 5.4e-48 163.7 0.0 1.2 1 0 0 1 1 1 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EMC89048.1 - 9.5e-37 126.7 0.2 4.5e-31 108.0 0.1 4.0 3 1 1 4 4 4 3 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 EMC89048.1 - 2.1e-23 81.7 7.1 1.1e-10 41.0 0.5 4.7 4 0 0 4 4 4 4 Prenyltransferase and squalene oxidase repeat Pec_lyase PF09492.10 EMC89048.1 - 0.0016 17.9 0.0 17 4.7 0.0 3.4 1 1 1 3 3 3 3 Pectic acid lyase DUF4817 PF16087.5 EMC89048.1 - 0.018 14.8 0.0 0.063 13.1 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain (DUF4817) WD40 PF00400.32 EMC89049.1 - 2.6e-34 116.7 26.7 3e-06 27.9 0.5 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC89049.1 - 3.7e-05 23.9 4.4 0.044 14.1 0.1 4.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 EMC89049.1 - 0.0015 19.0 0.0 0.0028 18.2 0.0 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain zf-RING_9 PF13901.6 EMC89050.1 - 8.6e-69 231.6 9.7 8.9e-68 228.3 8.1 2.4 2 0 0 2 2 2 1 Putative zinc-RING and/or ribbon PH PF00169.29 EMC89050.1 - 3.4e-12 46.8 0.5 6.9e-09 36.2 0.0 3.0 3 0 0 3 3 3 2 PH domain PH_13 PF16652.5 EMC89050.1 - 0.04 13.7 0.5 2.3 8.0 0.0 2.8 2 1 1 3 3 3 0 Pleckstrin homology domain Frizzled PF01534.17 EMC89051.1 - 3.1e-100 335.4 5.4 3.5e-100 335.2 5.4 1.0 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region FxsA PF04186.13 EMC89051.1 - 0.014 15.6 3.1 4 7.6 0.0 3.6 2 1 2 4 4 4 0 FxsA cytoplasmic membrane protein Dicty_CAR PF05462.11 EMC89051.1 - 0.21 10.7 7.1 0.018 14.2 2.7 1.5 2 0 0 2 2 2 0 Slime mold cyclic AMP receptor DUF2269 PF10027.9 EMC89051.1 - 5.3 7.1 9.4 1.6 8.8 2.7 2.2 1 1 1 2 2 2 0 Predicted integral membrane protein (DUF2269) Cyclin_N PF00134.23 EMC89052.1 - 8e-16 57.9 0.2 1.4e-15 57.1 0.2 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EMC89052.1 - 8.8e-11 42.4 0.2 1.2e-10 42.0 0.2 1.4 1 0 0 1 1 1 1 Cyclin Methyltransf_16 PF10294.9 EMC89053.1 - 3.7e-35 121.2 0.0 4.4e-35 121.0 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 EMC89053.1 - 0.00013 21.4 0.0 0.00015 21.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EMC89053.1 - 0.00053 19.6 0.0 0.00072 19.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 EMC89053.1 - 0.00056 19.8 0.0 0.00074 19.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain MOR2-PAG1_mid PF14228.6 EMC89053.1 - 0.055 11.1 0.0 0.064 10.9 0.0 1.0 1 0 0 1 1 1 0 Cell morphogenesis central region Methyltransf_25 PF13649.6 EMC89053.1 - 0.059 14.1 0.0 0.1 13.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 EMC89053.1 - 0.085 12.6 0.0 0.21 11.4 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain pKID PF02173.17 EMC89054.1 - 1.2e-21 75.9 2.5 3e-21 74.6 2.5 1.7 1 0 0 1 1 1 1 pKID domain bZIP_1 PF00170.21 EMC89054.1 - 1.5e-18 66.6 11.6 2.6e-18 65.9 11.6 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMC89054.1 - 5.8e-07 29.5 12.2 1.3e-06 28.4 12.2 1.6 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EMC89054.1 - 0.0026 18.2 5.5 0.0079 16.7 5.5 1.7 1 0 0 1 1 1 1 bZIP Maf transcription factor Rh5 PF18515.1 EMC89054.1 - 0.04 13.2 1.5 0.058 12.7 1.5 1.2 1 0 0 1 1 1 0 Rh5 coiled-coil domain DUF4988 PF16378.5 EMC89054.1 - 0.049 13.3 1.3 1 9.0 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function zf-H2C2_2 PF13465.6 EMC89055.1 - 8.7e-10 38.6 20.8 1.7e-05 25.0 0.7 3.7 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 EMC89055.1 - 6.2e-08 32.7 23.0 0.00013 22.3 0.5 3.8 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC89055.1 - 0.008 16.9 19.7 0.057 14.3 0.7 4.1 4 0 0 4 4 4 2 C2H2-type zinc finger FOXP-CC PF16159.5 EMC89055.1 - 0.035 14.7 3.6 1.4 9.6 0.4 2.7 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 EMC89055.1 - 0.45 10.9 5.9 0.17 12.2 2.6 2.1 2 1 1 3 3 3 0 C2H2-type zinc ribbon zf-H2C2_5 PF13909.6 EMC89055.1 - 6 6.7 23.7 0.3 10.9 2.1 4.3 4 1 0 4 4 4 0 C2H2-type zinc-finger domain Peptidase_M14 PF00246.24 EMC89056.1 - 2e-88 297.0 0.8 2.4e-88 296.7 0.8 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 EMC89056.1 - 3.1e-14 53.1 1.2 7.6e-14 51.9 1.2 1.7 1 0 0 1 1 1 1 Carboxypeptidase activation peptide DUF1642 PF07852.11 EMC89056.1 - 0.00012 22.6 0.2 0.00027 21.5 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1642) FAST_1 PF06743.15 EMC89057.1 - 3.7e-17 62.0 7.9 1.3e-16 60.3 0.2 4.2 5 0 0 5 5 5 1 FAST kinase-like protein, subdomain 1 FAST_2 PF08368.12 EMC89057.1 - 5.6e-09 36.7 0.3 2.2e-08 34.7 0.0 2.3 2 0 0 2 2 2 1 FAST kinase-like protein, subdomain 2 RAP PF08373.10 EMC89057.1 - 1.1e-07 31.8 0.0 2.7e-07 30.6 0.0 1.7 1 0 0 1 1 1 1 RAP domain Ldh_1_C PF02866.18 EMC89058.1 - 1.7e-08 34.6 0.0 1.9e-06 27.9 0.0 2.4 2 0 0 2 2 2 2 lactate/malate dehydrogenase, alpha/beta C-terminal domain EF-hand_3 PF09069.11 EMC89059.1 - 1.6e-18 66.9 0.0 2.3e-18 66.4 0.0 1.2 1 0 0 1 1 1 1 EF-hand EF-hand_2 PF09068.11 EMC89059.1 - 0.00077 19.6 0.0 0.0014 18.8 0.0 1.4 1 0 0 1 1 1 1 EF hand Ail_Lom PF06316.11 EMC89060.1 - 0.25 11.0 0.0 0.26 11.0 0.0 1.0 1 0 0 1 1 1 0 Enterobacterial Ail/Lom protein zf-DBF PF07535.12 EMC89062.1 - 6.9e-07 29.3 10.0 2.2e-06 27.7 10.0 1.9 1 0 0 1 1 1 1 DBF zinc finger 7tm_1 PF00001.21 EMC89063.1 - 7.2e-43 146.8 23.0 1e-42 146.3 23.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 EMC89063.1 - 0.00026 20.4 5.0 0.00026 20.4 5.0 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw EF1_GNE PF00736.19 EMC89064.1 - 2.9e-37 126.7 0.2 5.6e-37 125.8 0.2 1.5 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 EMC89064.1 - 2e-13 50.5 9.7 8.1e-13 48.6 9.7 2.1 1 0 0 1 1 1 1 Eukaryotic elongation factor 1 beta central acidic region GST_C_3 PF14497.6 EMC89064.1 - 0.028 14.6 0.3 1.4 9.1 0.0 2.4 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Tnp_22_trimer PF17489.2 EMC89064.1 - 0.052 13.5 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 L1 transposable element trimerization domain GST_C_6 PF17171.4 EMC89064.1 - 0.063 13.1 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain YL1 PF05764.13 EMC89064.1 - 0.13 12.4 4.5 0.16 12.0 4.5 1.2 1 0 0 1 1 1 0 YL1 nuclear protein Molybdopterin PF00384.22 EMC89065.1 - 3.5e-75 253.6 0.0 2.3e-74 250.9 0.0 1.9 1 1 0 1 1 1 1 Molybdopterin oxidoreductase Fer2_4 PF13510.6 EMC89065.1 - 8.3e-18 64.2 1.6 8.7e-18 64.2 0.1 1.9 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain NADH_dhqG_C PF09326.11 EMC89065.1 - 1.7e-17 63.9 0.1 3.4e-17 62.8 0.1 1.6 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal NADH-G_4Fe-4S_3 PF10588.9 EMC89065.1 - 3e-17 61.8 0.1 7.8e-17 60.5 0.1 1.8 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2 PF00111.27 EMC89065.1 - 2.3e-09 37.1 0.5 2.3e-09 37.1 0.5 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.22 EMC89065.1 - 0.0088 15.8 0.5 1.1 8.9 0.1 2.7 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Fer4 PF00037.27 EMC89065.1 - 0.4 10.6 2.4 16 5.5 0.4 2.7 2 0 0 2 2 2 0 4Fe-4S binding domain zf-C3Hc3H PF13891.6 EMC89066.1 - 1.6e-17 63.6 5.8 1.6e-17 63.6 5.8 2.2 2 0 0 2 2 2 1 Potential DNA-binding domain CUB PF00431.20 EMC89067.1 - 5.1e-59 197.4 0.0 1.8e-29 102.3 0.0 2.7 2 0 0 2 2 2 2 CUB domain F5_F8_type_C PF00754.25 EMC89067.1 - 8.4e-54 181.1 2.4 3e-26 92.0 1.3 2.5 2 0 0 2 2 2 2 F5/8 type C domain DUF3481 PF11980.8 EMC89067.1 - 2.3e-42 142.5 0.5 4.5e-42 141.6 0.5 1.5 1 0 0 1 1 1 1 C-terminal domain of neuropilin glycoprotein MAM PF00629.23 EMC89067.1 - 6.8e-33 113.8 0.0 1.7e-32 112.6 0.0 1.7 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu DUF1804 PF08822.11 EMC89067.1 - 0.11 12.5 0.0 21 5.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1804) PDZ PF00595.24 EMC89068.1 - 2.7e-37 127.0 2.2 5.2e-18 65.2 0.1 3.8 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 EMC89068.1 - 1.2e-19 69.9 0.1 3.3e-09 36.4 0.1 3.4 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 EMC89068.1 - 4e-14 52.7 0.1 1.8e-07 31.4 0.0 3.5 3 0 0 3 3 3 2 PDZ domain SMYLE_N PF18615.1 EMC89068.1 - 0.039 13.5 3.5 0.095 12.2 3.5 1.6 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain V-set_2 PF15910.5 EMC89070.1 - 1e-36 125.5 2.5 1.4e-36 125.0 2.5 1.2 1 0 0 1 1 1 1 ICOS V-set domain FAM176 PF14851.6 EMC89070.1 - 0.037 13.7 0.2 0.066 12.9 0.2 1.3 1 0 0 1 1 1 0 FAM176 family EphA2_TM PF14575.6 EMC89070.1 - 0.22 12.5 0.9 0.85 10.5 0.1 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TMEM108 PF15759.5 EMC89070.1 - 1.3 7.9 3.8 1.8 7.4 3.8 1.2 1 0 0 1 1 1 0 TMEM108 family V-set PF07686.17 EMC89071.1 - 7.5e-11 42.2 0.1 1.1e-10 41.7 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain V-set_2 PF15910.5 EMC89071.1 - 1.7e-09 37.7 0.1 2.4e-09 37.3 0.1 1.2 1 0 0 1 1 1 1 ICOS V-set domain Ig_6 PF18452.1 EMC89071.1 - 0.00091 18.7 0.0 0.0023 17.5 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC89071.1 - 0.0075 16.8 0.0 0.013 16.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC89071.1 - 0.055 13.6 0.0 0.074 13.1 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain V-set_2 PF15910.5 EMC89072.1 - 5e-12 45.9 0.7 5e-12 45.9 0.7 1.6 2 0 0 2 2 2 1 ICOS V-set domain V-set PF07686.17 EMC89072.1 - 1e-05 25.6 0.5 1.8e-05 24.8 0.5 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain RA PF00788.23 EMC89073.1 - 1.7e-13 51.0 2.8 4.1e-13 49.8 0.3 2.6 2 1 1 3 3 3 1 Ras association (RalGDS/AF-6) domain PH PF00169.29 EMC89073.1 - 4.5e-11 43.2 0.2 1e-10 42.0 0.2 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EMC89073.1 - 0.0031 17.9 0.7 0.0031 17.9 0.7 2.8 2 2 0 2 2 2 1 Pleckstrin homology domain RBD PF02196.15 EMC89073.1 - 0.0065 16.5 0.0 0.024 14.7 0.0 2.0 1 0 0 1 1 1 1 Raf-like Ras-binding domain FERM_N PF09379.10 EMC89073.1 - 0.02 14.9 0.2 0.048 13.6 0.2 1.7 1 0 0 1 1 1 0 FERM N-terminal domain Abi_HHR PF07815.14 EMC89074.1 - 2.9e-35 120.3 0.2 5.4e-35 119.4 0.2 1.5 1 0 0 1 1 1 1 Abl-interactor HHR SH3_9 PF14604.6 EMC89074.1 - 8.3e-18 64.0 0.2 1.4e-17 63.2 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC89074.1 - 3.7e-16 58.5 0.2 5.9e-16 57.8 0.2 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC89074.1 - 8e-13 47.9 0.1 1.6e-12 46.9 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain p450 PF00067.22 EMC89075.1 - 2.1e-47 162.0 0.1 2.6e-47 161.6 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_S51 PF03575.17 EMC89076.1 - 1.5e-54 184.8 0.0 1.7e-54 184.6 0.0 1.0 1 0 0 1 1 1 1 Peptidase family S51 DUF1148 PF06618.11 EMC89078.1 - 0.11 12.7 0.1 1.4 9.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1148) BsuBI_PstI_RE PF06616.11 EMC89079.1 - 0.027 13.8 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 BsuBI/PstI restriction endonuclease domain Iso_dh PF00180.20 EMC89080.1 - 6.7e-79 265.6 0.0 8.1e-79 265.3 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF3364 PF11844.8 EMC89080.1 - 0.13 12.6 0.2 3.8 7.8 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3364) PIP5K PF01504.18 EMC89081.1 - 7e-40 137.0 1.5 5.2e-30 104.6 1.1 2.9 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 EMC89081.1 - 4.8e-30 104.6 0.2 7.8e-30 103.9 0.2 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 EMC89081.1 - 9.5e-16 57.7 14.0 9.5e-16 57.7 14.0 2.3 2 0 0 2 2 2 1 FYVE zinc finger DEP PF00610.21 EMC89081.1 - 1.2e-05 25.3 0.0 3.6e-05 23.7 0.0 1.9 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Thioredoxin PF00085.20 EMC89082.1 - 7.6e-95 311.7 0.1 3e-24 85.0 0.1 5.8 6 0 0 6 6 6 4 Thioredoxin DnaJ PF00226.31 EMC89082.1 - 3.1e-24 84.9 2.8 6.3e-24 83.9 2.8 1.6 1 0 0 1 1 1 1 DnaJ domain Thioredoxin_2 PF13098.6 EMC89082.1 - 4.5e-14 52.8 2.3 0.00071 20.0 0.0 6.3 4 3 0 4 4 4 3 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EMC89082.1 - 4.9e-12 46.0 0.7 0.075 13.4 0.0 5.9 4 2 2 6 6 6 3 Thioredoxin-like Thioredoxin_6 PF13848.6 EMC89082.1 - 2.1e-11 44.1 0.0 0.0056 16.6 0.0 3.7 2 1 1 3 3 3 3 Thioredoxin-like domain OST3_OST6 PF04756.13 EMC89082.1 - 2.8e-09 36.8 0.0 0.02 14.2 0.0 4.3 3 1 1 4 4 4 4 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 EMC89082.1 - 1.9e-08 34.4 2.3 0.42 10.8 0.0 4.6 4 0 0 4 4 4 3 Thioredoxin-like AhpC-TSA PF00578.21 EMC89082.1 - 1.3e-07 31.6 2.3 0.67 9.9 0.0 4.6 4 0 0 4 4 4 3 AhpC/TSA family Redoxin PF08534.10 EMC89082.1 - 2.2e-07 30.7 2.5 0.14 11.8 0.0 3.6 4 0 0 4 4 4 3 Redoxin Thioredoxin_9 PF14595.6 EMC89082.1 - 0.0001 22.1 2.6 3.3 7.5 0.2 3.7 2 1 0 3 3 3 2 Thioredoxin TraF PF13728.6 EMC89082.1 - 0.0011 18.8 0.9 0.28 11.0 0.0 3.5 4 0 0 4 4 4 1 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 EMC89082.1 - 0.014 15.4 0.1 3 8.0 0.0 2.9 3 0 0 3 3 3 0 Thioredoxin domain RMMBL PF07521.12 EMC89082.1 - 0.054 13.4 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain Calsequestrin PF01216.17 EMC89082.1 - 0.059 12.4 0.0 4.4 6.2 0.0 2.3 2 0 0 2 2 2 0 Calsequestrin Pkinase PF00069.25 EMC89083.1 - 9.2e-69 231.7 0.0 1.1e-68 231.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC89083.1 - 4.2e-35 121.3 0.0 5.6e-35 120.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC89083.1 - 0.0057 16.0 0.0 0.0094 15.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like HECT PF00632.25 EMC89084.1 - 3.3e-49 168.0 0.0 3.5e-49 167.9 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) baeRF_family3 PF18845.1 EMC89084.1 - 0.048 13.9 0.0 0.054 13.8 0.0 1.2 1 1 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 3 baeRF_family8 PF18851.1 EMC89084.1 - 0.061 13.4 0.0 0.083 13.0 0.0 1.2 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 8 DUF4720 PF15846.5 EMC89085.1 - 7.3e-47 157.2 0.1 8.4e-47 157.0 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4720) Ank_2 PF12796.7 EMC89086.1 - 5.9e-162 526.7 55.8 1.5e-18 67.2 0.6 14.8 2 2 12 15 15 15 15 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC89086.1 - 1.7e-153 497.2 53.9 3.5e-14 53.0 0.1 22.1 8 6 16 24 24 24 22 Ankyrin repeats (many copies) Ank PF00023.30 EMC89086.1 - 5.4e-147 472.5 76.5 2.7e-07 30.7 0.1 27.9 28 0 0 28 28 28 25 Ankyrin repeat Ank_5 PF13857.6 EMC89086.1 - 1.9e-114 372.2 66.2 9.9e-10 38.5 0.2 23.1 5 4 21 26 26 26 25 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC89086.1 - 6.7e-114 357.9 56.1 1.7e-06 27.9 0.4 28.1 28 0 0 28 28 28 23 Ankyrin repeat TatD_DNase PF01026.21 EMC89086.1 - 0.093 12.1 0.4 0.2 11.0 0.1 1.7 2 0 0 2 2 2 0 TatD related DNase Ribosomal_S6 PF01250.17 EMC89086.1 - 0.096 13.0 0.0 1.6 9.0 0.0 3.1 2 1 1 3 3 3 0 Ribosomal protein S6 SF3b1 PF08920.10 EMC89087.1 - 4.4e-47 159.5 6.6 4.4e-47 159.5 6.6 4.7 1 1 2 3 3 3 2 Splicing factor 3B subunit 1 HEAT_2 PF13646.6 EMC89087.1 - 3e-08 33.9 2.9 0.031 14.7 0.0 6.7 6 2 2 8 8 8 3 HEAT repeats HEAT PF02985.22 EMC89087.1 - 1.7e-07 30.9 4.8 1.2 9.6 0.1 8.0 9 0 0 9 9 8 1 HEAT repeat HEAT_EZ PF13513.6 EMC89087.1 - 2.9e-06 27.6 3.7 0.51 10.9 0.0 6.4 8 1 1 9 9 7 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EMC89087.1 - 2e-05 25.1 0.6 3 8.5 0.0 4.6 4 0 0 4 4 4 2 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EMC89087.1 - 0.0018 17.9 1.0 3.5 7.1 0.1 3.3 3 0 0 3 3 3 2 CLASP N terminal DUF3385 PF11865.8 EMC89087.1 - 0.0032 17.4 1.9 4 7.3 0.1 4.9 3 1 0 4 4 4 1 Domain of unknown function (DUF3385) Cnd1 PF12717.7 EMC89087.1 - 0.0048 17.0 8.0 5.7 7.0 0.0 5.6 6 1 1 8 8 8 2 non-SMC mitotic condensation complex subunit 1 UME PF08064.13 EMC89087.1 - 0.0068 16.3 0.1 6 6.8 0.0 5.1 6 1 1 7 7 7 1 UME (NUC010) domain Adaptin_N PF01602.20 EMC89087.1 - 0.012 14.2 2.6 0.19 10.3 2.6 2.8 1 1 0 1 1 1 0 Adaptin N terminal region NUC173 PF08161.12 EMC89087.1 - 0.012 15.2 0.2 2.5 7.7 0.0 4.1 4 1 0 4 4 4 0 NUC173 domain DNA_pol_phi PF04931.13 EMC89087.1 - 0.018 13.2 0.0 3 5.8 0.0 2.2 2 0 0 2 2 2 0 DNA polymerase phi DRIM PF07539.12 EMC89087.1 - 0.024 13.0 0.1 5.5 5.2 0.0 3.3 3 1 0 4 4 4 0 Down-regulated in metastasis UNC45-central PF11701.8 EMC89087.1 - 0.027 14.5 0.3 0.11 12.5 0.0 2.2 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central Polyketide_cyc PF03364.20 EMC89088.1 - 1e-10 41.9 0.0 1.5e-10 41.4 0.0 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Cpn60_TCP1 PF00118.24 EMC89089.1 - 4.8e-83 279.4 14.5 1.4e-82 277.9 14.5 1.6 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family RE_TdeIII PF09520.10 EMC89089.1 - 1.3 8.7 3.4 15 5.2 0.4 2.3 2 0 0 2 2 2 0 Type II restriction endonuclease, TdeIII 4HB_MCP_1 PF12729.7 EMC89089.1 - 2.1 7.9 5.8 5.7 6.4 1.6 2.3 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction Cpn10 PF00166.21 EMC89090.1 - 1e-24 86.4 0.4 1.2e-24 86.2 0.4 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Mob1_phocein PF03637.17 EMC89091.1 - 7.2e-35 120.5 0.7 9.2e-35 120.2 0.7 1.0 1 0 0 1 1 1 1 Mob1/phocein family Raftlin PF15250.6 EMC89092.1 - 1.7e-180 600.8 0.0 2.5e-179 596.9 0.0 1.9 1 1 0 1 1 1 1 Raftlin RRM_1 PF00076.22 EMC89093.1 - 1.1e-19 70.1 0.6 1.8e-19 69.3 0.6 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EMC89093.1 - 0.00033 20.6 0.2 0.0005 20.1 0.2 1.2 1 0 0 1 1 1 1 RNA binding motif RRM_7 PF16367.5 EMC89093.1 - 0.0011 19.1 0.2 0.0041 17.2 0.2 2.0 1 1 0 1 1 1 1 RNA recognition motif PHM7_cyt PF14703.6 EMC89093.1 - 0.052 13.8 1.5 0.15 12.3 0.0 2.2 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter PI-PLC-X PF00388.19 EMC89094.1 - 1e-52 177.6 0.1 2e-52 176.6 0.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EMC89094.1 - 1.4e-41 141.5 0.2 3.9e-41 140.0 0.1 1.9 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain PH_12 PF16457.5 EMC89094.1 - 1.8e-19 70.6 0.0 4.7e-19 69.2 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain C2 PF00168.30 EMC89094.1 - 7.3e-18 64.8 0.0 2.4e-17 63.1 0.0 1.9 2 0 0 2 2 2 1 C2 domain EF-hand_like PF09279.11 EMC89094.1 - 1.5e-14 54.3 0.0 4.3e-14 52.8 0.0 1.8 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like PH_14 PF17787.1 EMC89094.1 - 1e-07 31.9 0.2 3.3e-07 30.2 0.0 1.9 2 0 0 2 2 2 1 PH domain Mcp5_PH PF12814.7 EMC89094.1 - 0.0074 16.4 0.0 0.018 15.2 0.0 1.7 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology EF-hand_7 PF13499.6 EMC89094.1 - 0.009 16.4 2.2 0.031 14.7 0.1 2.8 3 0 0 3 3 3 1 EF-hand domain pair PH PF00169.29 EMC89094.1 - 0.06 13.9 0.0 0.22 12.0 0.0 2.0 1 0 0 1 1 1 0 PH domain UPF0565 PF10561.9 EMC89095.1 - 1.8e-96 322.9 0.1 2.1e-96 322.7 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0565 Polysacc_deac_1 PF01522.21 EMC89095.1 - 0.15 11.9 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide deacetylase Cupin_8 PF13621.6 EMC89096.1 - 7.5e-40 137.2 0.0 9.1e-40 137.0 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 EMC89096.1 - 3.4e-11 43.2 0.1 4.9e-11 42.7 0.1 1.5 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 EMC89096.1 - 0.048 14.1 0.0 0.093 13.2 0.0 1.5 1 0 0 1 1 1 0 JmjC domain, hydroxylase Sox_N PF12444.8 EMC89097.1 - 5.5e-07 30.6 11.9 2.6 9.3 0.0 8.4 3 3 7 10 10 10 3 Sox developmental protein N terminal Orthopox_A36R PF05950.11 EMC89097.1 - 0.0014 18.8 2.7 2.1 8.5 0.1 3.8 2 2 3 5 5 5 3 Orthopoxvirus A36R protein zf-H2C2_2 PF13465.6 EMC89098.1 - 1.1e-86 281.6 86.5 2.5e-08 34.0 1.5 12.1 12 0 0 12 12 12 12 Zinc-finger double domain zf-C2H2 PF00096.26 EMC89098.1 - 1.4e-50 167.0 129.7 3.2e-06 27.3 5.2 12.5 13 0 0 13 13 12 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC89098.1 - 7.5e-26 88.6 111.4 0.002 18.8 2.0 12.2 12 0 0 12 12 12 10 C2H2-type zinc finger zf_UBZ PF18439.1 EMC89098.1 - 5.6e-08 32.2 53.3 0.098 12.3 0.4 10.9 11 0 0 11 11 11 5 Ubiquitin-Binding Zinc Finger zinc_ribbon_15 PF17032.5 EMC89098.1 - 2.1e-06 28.4 36.9 0.26 12.0 0.5 6.2 1 1 5 6 6 6 5 zinc-ribbon family Zn-ribbon_8 PF09723.10 EMC89098.1 - 0.00013 22.0 60.6 0.049 13.7 1.6 8.5 5 1 5 10 10 9 6 Zinc ribbon domain DUF3850 PF12961.7 EMC89098.1 - 0.00031 20.7 0.3 11 6.2 0.0 6.5 5 1 5 10 10 9 0 Domain of unknown function (DUF3850) HypA PF01155.19 EMC89098.1 - 0.00085 19.3 38.0 0.56 10.2 0.5 6.6 1 1 6 7 7 7 4 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-AN1 PF01428.16 EMC89098.1 - 0.0037 17.4 83.3 0.5 10.6 2.2 11.7 5 2 7 12 12 11 4 AN1-like Zinc finger Ta0938 PF11494.8 EMC89098.1 - 0.0082 16.4 16.6 2.2 8.6 0.1 6.1 1 1 5 6 6 6 1 Ta0938 CpXC PF14353.6 EMC89098.1 - 0.018 15.1 42.9 1.1 9.3 0.1 10.5 4 2 6 12 12 12 0 CpXC protein FAM178 PF14816.6 EMC89098.1 - 0.019 13.9 10.7 2.8 6.8 0.6 5.3 2 1 4 6 6 6 0 Family of unknown function, FAM178 FYDLN_acid PF09538.10 EMC89098.1 - 0.027 15.1 26.1 32 5.3 0.3 9.4 1 1 7 8 8 8 0 Protein of unknown function (FYDLN_acid) zf-met PF12874.7 EMC89098.1 - 0.27 11.7 0.1 0.27 11.7 0.1 8.8 10 0 0 10 10 9 0 Zinc-finger of C2H2 type DUF3268 PF11672.8 EMC89098.1 - 0.37 11.1 29.5 2.7 8.3 0.8 6.0 1 1 3 7 7 7 0 zinc-finger-containing domain DUF4934 PF16288.5 EMC89098.1 - 0.39 10.6 3.0 56 3.7 0.1 4.6 2 1 2 5 5 5 0 Domain of unknown function (DUF4934) LIM PF00412.22 EMC89098.1 - 0.45 10.8 58.9 0.56 10.5 5.2 8.5 1 1 7 9 9 9 0 LIM domain zf-C2H2_jaz PF12171.8 EMC89098.1 - 1.9 8.9 0.0 1.9 8.9 0.0 8.6 11 0 0 11 11 10 0 Zinc-finger double-stranded RNA-binding zf-trcl PF13451.6 EMC89098.1 - 2 8.4 46.4 4.4 7.3 0.2 10.2 11 0 0 11 11 11 0 Probable zinc-ribbon domain zf-C2HE PF16278.5 EMC89098.1 - 3.1 8.3 66.4 9.6 6.7 1.0 11.1 1 1 9 10 10 10 0 C2HE / C2H2 / C2HC zinc-binding finger Dopey_N PF04118.14 EMC89099.1 - 0.00089 18.5 0.0 0.00093 18.4 0.0 1.1 1 0 0 1 1 1 1 Dopey, N-terminal Tti2 PF10521.9 EMC89099.1 - 0.02 14.5 0.0 0.023 14.3 0.0 1.1 1 0 0 1 1 1 0 Tti2 family Thiolase_N PF00108.23 EMC89100.1 - 9.1e-74 248.1 0.5 3e-72 243.1 0.5 2.2 1 1 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EMC89100.1 - 1.5e-49 166.8 0.0 3.3e-49 165.6 0.0 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EMC89100.1 - 8.9e-09 35.3 1.3 7.9e-08 32.2 0.4 2.7 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain HEM4 PF02602.15 EMC89100.1 - 0.036 13.4 0.0 0.14 11.4 0.1 2.0 2 0 0 2 2 2 0 Uroporphyrinogen-III synthase HemD ACP_syn_III PF08545.10 EMC89100.1 - 1.3 8.9 5.1 5.3 7.0 0.2 3.2 4 0 0 4 4 4 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 3HCDH_N PF02737.18 EMC89101.1 - 3.4e-57 193.2 1.3 6.5e-57 192.3 1.3 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.20 EMC89101.1 - 5.1e-40 137.4 0.1 7.7e-40 136.8 0.1 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase 3HCDH PF00725.22 EMC89101.1 - 5.2e-26 91.1 0.2 1.5e-25 89.6 0.2 1.9 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_2 PF16113.5 EMC89101.1 - 2.1e-24 86.7 0.0 4.5e-24 85.6 0.0 1.5 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase DUF3479 PF11965.8 EMC89101.1 - 0.15 12.1 0.3 3.4 7.8 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3479) CABIT PF12736.7 EMC89102.1 - 2.5e-57 194.3 1.3 6.5e-41 140.5 0.2 3.0 2 1 1 3 3 3 3 Cell-cycle sustaining, positive selection, 4PPT_N PF17837.1 EMC89103.1 - 2.3e-05 24.4 22.8 1.2 9.3 0.0 7.0 2 2 4 6 6 6 4 4'-phosphopantetheinyl transferase N-terminal domain YqzH PF14164.6 EMC89103.1 - 0.25 11.4 0.3 9.4 6.4 0.0 2.6 2 0 0 2 2 2 0 YqzH-like protein Pkinase PF00069.25 EMC89105.1 - 1.1e-32 113.5 0.1 1.2e-32 113.3 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC89105.1 - 3.8e-18 65.7 0.1 4.3e-18 65.5 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMC89105.1 - 0.00012 21.5 0.0 0.00012 21.5 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EMC89106.1 - 4e-26 92.0 0.0 4.8e-26 91.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC89106.1 - 1.9e-06 27.4 0.0 2.3e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC89107.1 - 1.9e-71 240.5 0.1 2.6e-71 240.1 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC89107.1 - 2.2e-30 105.8 0.1 3.3e-30 105.2 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EMC89107.1 - 5.4e-05 23.2 0.3 0.00016 21.7 0.0 1.9 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EMC89107.1 - 0.00013 21.4 0.0 0.0002 20.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EMC89107.1 - 0.0024 17.3 0.2 0.026 13.9 0.0 2.5 3 0 0 3 3 3 1 Kinase-like Haspin_kinase PF12330.8 EMC89107.1 - 0.011 14.7 0.0 0.02 13.9 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain DUF3754 PF12576.8 EMC89107.1 - 0.029 14.3 0.0 0.055 13.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3754) FTA2 PF13095.6 EMC89107.1 - 0.11 12.1 0.4 0.22 11.1 0.0 1.6 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 adh_short PF00106.25 EMC89109.1 - 2.2e-32 112.1 0.0 2.7e-32 111.8 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC89109.1 - 1.3e-18 67.5 0.0 1.4e-18 67.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 EMC89109.1 - 0.00019 20.9 0.0 0.00025 20.5 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) KR PF08659.10 EMC89109.1 - 0.017 15.0 0.0 0.021 14.7 0.0 1.1 1 0 0 1 1 1 0 KR domain RecA PF00154.21 EMC89109.1 - 0.036 13.5 0.1 0.052 13.0 0.1 1.4 1 1 0 1 1 1 0 recA bacterial DNA recombination protein GSG-1 PF07803.11 EMC89110.1 - 1.7e-45 153.7 0.3 3.1e-45 152.8 0.3 1.4 1 0 0 1 1 1 1 GSG1-like protein PMP22_Claudin PF00822.20 EMC89110.1 - 2.4e-08 34.0 8.1 4e-08 33.3 7.9 1.6 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC89110.1 - 8.1e-06 25.7 12.1 4.9e-05 23.2 12.1 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction L_HMGIC_fpl PF10242.9 EMC89110.1 - 0.012 15.8 7.3 0.035 14.3 7.3 1.8 1 1 0 1 1 1 0 Lipoma HMGIC fusion partner-like protein 7tm_2 PF00002.24 EMC89111.1 - 6e-80 268.1 16.6 7.6e-80 267.7 16.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 EMC89111.1 - 7.4e-14 51.8 4.7 1.8e-13 50.6 4.7 1.7 1 0 0 1 1 1 1 Hormone receptor domain SUR7 PF06687.12 EMC89111.1 - 0.0084 15.8 0.1 0.023 14.3 0.0 1.7 2 0 0 2 2 2 1 SUR7/PalI family Arm PF00514.23 EMC89113.1 - 2.4e-32 109.9 1.7 5.3e-09 35.8 0.0 7.0 7 0 0 7 7 7 4 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 EMC89113.1 - 1.5e-08 34.5 1.1 0.00047 19.7 0.1 2.5 2 1 0 2 2 2 2 Armadillo-like Atx10homo_assoc PF09759.9 EMC89113.1 - 0.00027 20.9 0.1 0.015 15.3 0.1 3.2 4 0 0 4 4 4 1 Spinocerebellar ataxia type 10 protein domain HEAT PF02985.22 EMC89113.1 - 0.0075 16.4 0.0 4.4 7.8 0.0 3.7 3 0 0 3 3 3 1 HEAT repeat HEAT_2 PF13646.6 EMC89113.1 - 0.016 15.6 0.3 0.17 12.3 0.1 2.5 2 0 0 2 2 2 0 HEAT repeats Symplekin_C PF12295.8 EMC89113.1 - 0.026 14.6 0.4 1.9 8.5 0.1 2.8 3 0 0 3 3 3 0 Symplekin tight junction protein C terminal Rhabdo_ncap_2 PF03216.13 EMC89113.1 - 0.066 12.7 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Rhabdovirus nucleoprotein HEAT_EZ PF13513.6 EMC89113.1 - 0.19 12.3 0.4 25 5.5 0.0 3.8 4 0 0 4 4 4 0 HEAT-like repeat DUF383 PF04063.14 EMC89113.1 - 0.65 9.6 4.3 13 5.4 0.1 3.6 2 2 1 4 4 4 0 Domain of unknown function (DUF383) DUF4535 PF15054.6 EMC89115.1 - 4.3e-18 64.8 0.3 4.6e-18 64.7 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4535) Na_sulph_symp PF00939.19 EMC89116.1 - 9.7e-96 321.6 17.9 1.2e-95 321.3 17.9 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 EMC89116.1 - 4.2e-34 118.1 19.2 3e-17 62.8 0.0 3.1 2 1 1 3 3 3 3 Citrate transporter SbmA_BacA PF05992.12 EMC89116.1 - 1.3 8.4 8.1 3.3 7.0 1.9 2.5 2 0 0 2 2 2 0 SbmA/BacA-like family FAM180 PF15173.6 EMC89117.1 - 2.6e-60 202.4 0.3 3.2e-60 202.1 0.3 1.1 1 0 0 1 1 1 1 FAM180 family DUF1195 PF06708.11 EMC89117.1 - 0.31 10.8 2.4 11 5.7 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1195) Pkinase PF00069.25 EMC89118.1 - 4.8e-57 193.3 0.0 6.1e-57 193.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC89118.1 - 7.6e-19 68.0 0.0 1.1e-18 67.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EMC89118.1 - 1.6e-05 24.9 0.0 4e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 EMC89118.1 - 0.0018 17.9 0.0 0.0042 16.7 0.0 1.6 1 1 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 EMC89118.1 - 0.005 16.4 0.9 0.0082 15.7 0.9 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kinase-like PF14531.6 EMC89118.1 - 0.0064 15.8 0.0 0.035 13.4 0.0 2.0 1 1 1 2 2 2 1 Kinase-like YrbL-PhoP_reg PF10707.9 EMC89118.1 - 0.039 13.5 0.5 0.11 12.0 0.0 1.9 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Kdo PF06293.14 EMC89118.1 - 0.068 12.5 0.1 0.14 11.5 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RAD51_interact PF15696.5 EMC89120.1 - 1.1e-18 67.0 3.2 3e-18 65.6 3.2 1.8 1 0 0 1 1 1 1 RAD51 interacting motif DUF2362 PF10154.9 EMC89121.1 - 1.9e-174 581.4 10.3 2.2e-174 581.1 10.3 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2362) Rpr2 PF04032.16 EMC89121.1 - 0.11 12.8 0.4 0.3 11.4 0.4 1.9 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain KRTDAP PF15200.6 EMC89121.1 - 1.1 9.1 3.2 27 4.6 0.7 2.3 2 0 0 2 2 2 0 Keratinocyte differentiation-associated EAP30 PF04157.16 EMC89121.1 - 4 6.7 7.2 28 3.9 7.2 2.0 1 1 0 1 1 1 0 EAP30/Vps36 family FGF PF00167.18 EMC89122.1 - 9e-42 142.1 0.1 1.1e-41 141.8 0.1 1.1 1 0 0 1 1 1 1 Fibroblast growth factor FGF PF00167.18 EMC89123.1 - 9.8e-20 70.9 0.0 1.4e-19 70.4 0.0 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Cyclin_N PF00134.23 EMC89124.1 - 3.5e-37 127.0 1.3 6.6e-37 126.1 1.3 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EMC89124.1 - 3.4e-20 72.3 0.2 2.6e-19 69.4 0.0 2.2 2 1 0 2 2 2 1 Cyclin, C-terminal domain K-cyclin_vir_C PF09080.10 EMC89124.1 - 0.04 14.3 0.0 0.069 13.6 0.0 1.3 1 0 0 1 1 1 0 K cyclin, C terminal SbcD_C PF12320.8 EMC89124.1 - 0.099 13.0 0.1 0.22 11.8 0.1 1.6 1 0 0 1 1 1 0 Type 5 capsule protein repressor C-terminal domain 3Beta_HSD PF01073.19 EMC89125.1 - 1e-14 54.2 0.0 2.9e-09 36.4 0.0 2.1 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EMC89125.1 - 8.5e-13 48.3 0.0 2.6e-11 43.4 0.0 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EMC89125.1 - 1e-09 37.9 0.0 4.6e-08 32.5 0.0 2.1 1 1 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.13 EMC89125.1 - 2.3e-09 37.1 0.0 1.4e-08 34.6 0.0 1.9 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMC89125.1 - 1e-08 35.3 0.0 2.1e-08 34.3 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EMC89125.1 - 0.00029 20.1 0.0 0.44 9.7 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 EMC89125.1 - 0.01 15.3 0.0 0.054 12.9 0.0 2.0 1 1 1 2 2 2 1 GDP-mannose 4,6 dehydratase Glycos_transf_2 PF00535.26 EMC89126.1 - 2.3e-23 82.8 0.1 3.5e-23 82.3 0.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 EMC89126.1 - 1.3e-10 41.6 0.0 2e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 EMC89126.1 - 0.022 14.4 0.0 0.045 13.4 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain of galactosyltransferase Glyco_tranf_2_3 PF13641.6 EMC89126.1 - 0.052 13.4 0.0 0.37 10.7 0.0 2.0 1 1 0 1 1 1 0 Glycosyltransferase like family 2 RE_HaeII PF09554.10 EMC89126.1 - 0.16 11.2 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 HaeII restriction endonuclease Avl9 PF09794.9 EMC89129.1 - 1.5e-10 40.4 0.1 4.6e-07 28.9 0.0 2.1 1 1 1 2 2 2 2 Transport protein Avl9 SPA PF08616.10 EMC89129.1 - 4.3e-10 39.5 0.0 8.2e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis DUF2347 PF09804.9 EMC89129.1 - 4.9e-08 32.9 0.0 1.1e-07 31.8 0.0 1.6 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) Toxin-deaminase PF14424.6 EMC89129.1 - 0.086 12.9 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 The BURPS668_1122 family of deaminases Pkinase PF00069.25 EMC89130.1 - 2.5e-65 220.5 0.0 3.5e-65 220.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC89130.1 - 6.5e-34 117.4 0.0 9.8e-34 116.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.19 EMC89130.1 - 6.9e-23 81.2 0.3 2e-22 79.7 0.1 1.9 2 0 0 2 2 2 1 Regulator of G protein signaling domain Kinase-like PF14531.6 EMC89130.1 - 6.2e-05 22.4 0.0 0.00011 21.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMC89130.1 - 0.0013 17.6 0.0 0.0039 16.0 0.0 1.6 1 1 0 1 1 1 1 Fungal protein kinase Arteri_nucleo PF01481.16 EMC89130.1 - 0.23 11.8 1.5 3.4 8.0 0.0 3.0 3 1 0 3 3 3 0 Arterivirus nucleocapsid protein DUF333 PF03891.15 EMC89131.1 - 0.13 12.5 0.2 9.4 6.5 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF333) RGS PF00615.19 EMC89132.1 - 6.6e-33 113.5 4.9 6.6e-33 113.5 4.9 1.5 2 0 0 2 2 2 1 Regulator of G protein signaling domain RGS-like PF09128.11 EMC89132.1 - 7.9e-05 22.5 0.1 0.00012 21.9 0.1 1.3 1 1 0 1 1 1 1 Regulator of G protein signalling-like domain RRM_1 PF00076.22 EMC89133.1 - 4.3e-60 199.5 0.0 1.2e-21 76.3 0.0 4.2 3 1 1 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMC89133.1 - 4.6e-09 36.0 0.0 5.1e-05 23.0 0.0 3.3 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_7 PF16367.5 EMC89133.1 - 7e-08 32.5 0.2 0.26 11.4 0.0 4.4 3 1 0 3 3 3 3 RNA recognition motif Nup35_RRM_2 PF14605.6 EMC89133.1 - 8.1e-05 22.5 0.3 0.15 12.1 0.0 3.5 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif Calcipressin PF04847.12 EMC89133.1 - 0.00091 19.0 0.0 0.39 10.4 0.0 2.6 3 0 0 3 3 3 2 Calcipressin Nup35_RRM PF05172.13 EMC89133.1 - 0.00093 19.1 0.2 0.36 10.8 0.2 3.5 1 1 1 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EMC89133.1 - 0.0098 15.9 0.0 12 6.0 0.0 3.2 3 0 0 3 3 3 1 RNA binding motif DbpA PF03880.15 EMC89133.1 - 0.15 12.1 0.0 4 7.5 0.0 2.8 3 0 0 3 3 3 0 DbpA RNA binding domain zf-C2H2_10 PF16588.5 EMC89134.1 - 0.28 10.9 0.1 0.28 10.9 0.1 2.6 3 0 0 3 3 3 0 C2H2 zinc-finger Syja_N PF02383.18 EMC89135.1 - 2.4e-98 329.4 0.5 4.2e-98 328.6 0.5 1.4 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.8 EMC89135.1 - 4.2e-23 81.3 0.0 2.3e-22 78.9 0.0 2.3 2 0 0 2 2 2 1 Inositol phosphatase HSM3_C PF18794.1 EMC89135.1 - 0.043 13.4 1.4 0.9 9.1 0.1 2.7 3 0 0 3 3 3 0 DNA mismatch repair protein HSM3, C terminal domain DHO_dh PF01180.21 EMC89135.1 - 0.11 11.7 0.1 0.27 10.4 0.1 1.6 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase MCM_bind PF09739.9 EMC89136.1 - 4.7e-239 794.7 0.0 5.4e-239 794.5 0.0 1.0 1 0 0 1 1 1 1 Mini-chromosome maintenance replisome factor DDHD PF02862.17 EMC89137.1 - 2e-57 194.9 0.2 4.7e-56 190.4 0.0 2.4 2 0 0 2 2 2 1 DDHD domain SAM_1 PF00536.30 EMC89137.1 - 2.8e-13 50.1 0.0 5.8e-13 49.1 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) WWE PF02825.20 EMC89137.1 - 3.6e-10 40.3 3.7 2.8e-05 24.6 0.4 2.7 1 1 1 2 2 2 2 WWE domain SAM_2 PF07647.17 EMC89137.1 - 0.00014 21.9 0.0 0.00038 20.5 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) IGR PF09597.10 EMC89137.1 - 0.028 14.5 0.0 0.089 12.9 0.0 1.9 1 0 0 1 1 1 0 IGR protein motif Sec8_exocyst PF04048.14 EMC89137.1 - 0.11 12.3 0.6 0.3 11.0 0.6 1.7 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain TGF_beta PF00019.20 EMC89138.1 - 3.3e-33 114.8 0.7 6.8e-33 113.8 0.7 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 EMC89138.1 - 1.9e-18 67.1 0.0 2.9e-18 66.5 0.0 1.2 1 0 0 1 1 1 1 TGF-beta propeptide SOBP PF15279.6 EMC89138.1 - 0.3 11.6 4.4 0.18 12.4 2.3 1.6 2 0 0 2 2 2 0 Sine oculis-binding protein Ubiq_cyt_C_chap PF03981.12 EMC89139.1 - 5.5e-42 143.2 0.1 7.3e-42 142.8 0.1 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone Chlorophyllase PF07224.11 EMC89139.1 - 0.085 11.9 0.4 0.15 11.1 0.4 1.3 1 0 0 1 1 1 0 Chlorophyllase FAM83 PF07894.12 EMC89140.1 - 6.7e-63 212.8 0.5 6.7e-63 212.8 0.5 2.0 2 0 0 2 2 2 1 FAM83 A-H PLDc_2 PF13091.6 EMC89140.1 - 0.032 14.1 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 PLD-like domain Actin PF00022.19 EMC89140.1 - 0.054 12.1 0.0 0.07 11.7 0.0 1.2 1 0 0 1 1 1 0 Actin eIF-6 PF01912.18 EMC89142.1 - 3.8e-39 134.1 0.1 7.6e-31 107.0 0.0 2.7 3 0 0 3 3 3 2 eIF-6 family Peptidase_M10 PF00413.24 EMC89143.1 - 1.3e-62 210.3 0.2 2.5e-62 209.4 0.2 1.5 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 EMC89143.1 - 2.2e-54 181.1 20.6 9.1e-16 57.5 0.9 4.5 4 0 0 4 4 4 4 Hemopexin DUF3377 PF11857.8 EMC89143.1 - 2.6e-29 101.0 1.8 4.1e-29 100.3 1.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) PG_binding_1 PF01471.18 EMC89143.1 - 3e-12 46.5 0.1 6.3e-12 45.5 0.1 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.24 EMC89143.1 - 0.00018 21.2 1.3 0.43 10.2 0.1 2.2 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) DUF4293 PF14126.6 EMC89143.1 - 0.0027 17.9 0.1 0.0048 17.2 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4293) Peptidase_M66 PF10462.9 EMC89143.1 - 0.04 12.9 0.4 0.066 12.2 0.4 1.3 1 0 0 1 1 1 0 Peptidase M66 Metallopep PF12044.8 EMC89143.1 - 0.048 12.3 0.1 0.071 11.7 0.1 1.2 1 0 0 1 1 1 0 Putative peptidase family Reprolysin_3 PF13582.6 EMC89143.1 - 0.061 13.8 0.3 0.2 12.2 0.4 1.8 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M54 PF07998.11 EMC89143.1 - 0.075 13.0 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Peptidase family M54 DUF4953 PF16313.5 EMC89143.1 - 0.094 11.9 0.2 0.17 11.1 0.2 1.3 1 0 0 1 1 1 0 Met-zincin Reprolysin_4 PF13583.6 EMC89143.1 - 0.25 11.0 0.1 0.49 10.0 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like SLAM PF06214.11 EMC89144.1 - 0.011 15.7 0.2 0.021 14.8 0.2 1.5 1 0 0 1 1 1 0 Signaling lymphocytic activation molecule (SLAM) protein V-set PF07686.17 EMC89145.1 - 0.00023 21.3 0.0 0.00074 19.7 0.0 1.9 2 1 1 3 3 3 1 Immunoglobulin V-set domain ig PF00047.25 EMC89145.1 - 0.004 17.3 1.2 0.45 10.7 0.0 3.0 3 0 0 3 3 3 1 Immunoglobulin domain I-set PF07679.16 EMC89145.1 - 0.023 14.7 0.0 0.11 12.6 0.0 2.2 2 1 0 2 2 2 0 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC89145.1 - 0.034 14.8 0.2 1.4 9.6 0.0 3.1 2 2 1 3 3 3 0 Immunoglobulin domain Izumo-Ig PF16706.5 EMC89145.1 - 0.13 12.3 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain Strabismus PF06638.11 EMC89146.1 - 2.7e-235 781.8 1.9 6e-235 780.6 1.9 1.5 1 1 0 1 1 1 1 Strabismus protein HLH PF00010.26 EMC89147.1 - 5.9e-19 67.8 0.2 5.9e-19 67.8 0.2 2.1 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain HTH_51 PF18558.1 EMC89147.1 - 0.06 13.2 0.1 0.24 11.3 0.0 1.8 1 1 1 2 2 2 0 Helix-turn-helix domain DUF4703 PF15775.5 EMC89147.1 - 1.3 8.8 4.7 1.9 8.3 4.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4703) Nicastrin PF05450.15 EMC89148.1 - 1.2e-71 241.0 0.8 1.7e-71 240.4 0.8 1.2 1 0 0 1 1 1 1 Nicastrin Ncstrn_small PF18266.1 EMC89148.1 - 7.6e-62 208.2 0.0 1.5e-61 207.2 0.0 1.5 1 0 0 1 1 1 1 Nicastrin small lobe Peptidase_M28 PF04389.17 EMC89148.1 - 1.1e-08 35.1 0.0 1.6e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 HydF_dimer PF18128.1 EMC89148.1 - 0.17 12.0 0.0 0.61 10.2 0.0 1.9 1 0 0 1 1 1 0 Hydrogen maturase F dimerization domain S_100 PF01023.19 EMC89149.1 - 7.3e-19 67.2 0.5 1.2e-18 66.5 0.1 1.6 2 0 0 2 2 2 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.32 EMC89149.1 - 1.8e-08 33.3 1.3 9.3e-07 28.0 0.4 2.3 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 EMC89149.1 - 3.3e-06 27.5 0.3 4.6e-06 27.0 0.3 1.4 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EMC89149.1 - 8.8e-06 25.3 0.8 0.01 15.7 0.3 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EMC89149.1 - 2.9e-05 23.3 2.5 0.00015 21.1 0.7 2.3 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 EMC89149.1 - 0.00024 20.9 0.3 0.0044 16.8 0.1 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_11 PF08976.11 EMC89149.1 - 0.0046 17.8 0.0 0.0055 17.6 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.7 EMC89149.1 - 0.03 14.3 0.0 0.034 14.1 0.0 1.2 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand S_100 PF01023.19 EMC89150.1 - 9.1e-11 41.3 0.0 1.5e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.6 EMC89150.1 - 0.00045 20.6 0.1 0.0014 19.0 0.1 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EMC89150.1 - 0.0021 17.4 1.0 0.0037 16.7 1.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 EMC89150.1 - 0.0091 15.4 1.3 0.019 14.4 1.3 1.6 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 EMC89150.1 - 0.01 15.7 0.2 0.018 14.9 0.2 1.3 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_4 PF12763.7 EMC89150.1 - 0.012 15.5 0.1 0.024 14.6 0.1 1.4 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand DUF5331 PF17265.2 EMC89150.1 - 0.033 13.9 1.6 24 4.7 0.0 4.0 3 0 0 3 3 3 0 Family of unknown function (DUF5331) EF-hand_6 PF13405.6 EMC89150.1 - 0.04 13.9 0.7 0.081 12.9 0.7 1.5 1 0 0 1 1 1 0 EF-hand domain S_100 PF01023.19 EMC89151.1 - 3e-07 30.0 0.0 5.5e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain HC2 PF07382.11 EMC89155.1 - 0.00025 21.2 26.5 0.00025 21.2 26.5 2.5 1 1 1 2 2 2 1 Histone H1-like nucleoprotein HC2 GATase_5 PF13507.6 EMC89155.1 - 0.0074 15.4 8.3 0.58 9.2 0.5 3.0 1 1 3 4 4 4 4 CobB/CobQ-like glutamine amidotransferase domain TIL PF01826.17 EMC89155.1 - 0.65 10.3 143.4 1.4 9.3 6.7 6.6 1 1 5 6 6 6 0 Trypsin Inhibitor like cysteine rich domain Keratin PF02422.16 EMC89157.1 - 5.8e-25 86.8 11.7 6.1e-25 86.7 11.7 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC89158.1 - 4.3e-28 96.8 11.0 4.8e-28 96.7 11.0 1.0 1 0 0 1 1 1 1 Keratin TIL PF01826.17 EMC89158.1 - 0.012 15.9 2.0 0.02 15.1 2.0 1.4 1 0 0 1 1 1 0 Trypsin Inhibitor like cysteine rich domain Keratin PF02422.16 EMC89159.1 - 1e-30 105.3 12.1 1.2e-30 105.0 12.1 1.1 1 0 0 1 1 1 1 Keratin DUF3432 PF11914.8 EMC89159.1 - 0.011 15.9 3.1 0.027 14.7 3.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3432) Cornifin PF02389.15 EMC89159.1 - 0.27 11.4 7.9 0.32 11.2 7.9 1.1 1 0 0 1 1 1 0 Cornifin (SPRR) family Keratin PF02422.16 EMC89160.1 - 1e-30 105.3 12.1 1.2e-30 105.0 12.1 1.1 1 0 0 1 1 1 1 Keratin DUF3432 PF11914.8 EMC89160.1 - 0.011 15.9 3.1 0.027 14.7 3.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3432) Cornifin PF02389.15 EMC89160.1 - 0.27 11.4 7.9 0.32 11.2 7.9 1.1 1 0 0 1 1 1 0 Cornifin (SPRR) family Keratin PF02422.16 EMC89161.1 - 3.7e-29 100.3 8.8 4.8e-29 99.9 8.8 1.2 1 0 0 1 1 1 1 Keratin Cornifin PF02389.15 EMC89161.1 - 0.0015 18.7 8.6 0.0015 18.7 8.6 1.3 1 1 0 1 1 1 1 Cornifin (SPRR) family DUF3432 PF11914.8 EMC89161.1 - 0.016 15.5 1.3 0.019 15.2 1.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3432) TMEM171 PF15471.6 EMC89161.1 - 0.069 12.1 0.6 0.072 12.1 0.6 1.1 1 0 0 1 1 1 0 Transmembrane protein family 171 Keratin PF02422.16 EMC89162.1 - 3.5e-29 100.4 6.1 3.7e-29 100.3 6.1 1.0 1 0 0 1 1 1 1 Keratin DUF3432 PF11914.8 EMC89162.1 - 0.18 12.1 4.7 0.24 11.7 4.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3432) Keratin PF02422.16 EMC89163.1 - 2.2e-27 94.6 8.3 2.5e-27 94.4 8.3 1.1 1 0 0 1 1 1 1 Keratin DUF3432 PF11914.8 EMC89163.1 - 7.7 6.8 13.0 9 6.6 10.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3432) Keratin PF02422.16 EMC89164.1 - 6.4e-26 89.9 6.7 7.1e-26 89.7 6.7 1.1 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC89165.1 - 6.8e-39 131.5 7.6 8.3e-39 131.2 7.6 1.1 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC89166.1 - 1.9e-39 133.3 7.9 2.3e-39 133.0 7.9 1.1 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC89167.1 - 3.9e-36 122.6 7.1 4.3e-36 122.5 7.1 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC89168.1 - 1.5e-38 130.4 8.1 1.7e-38 130.2 8.1 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC89169.1 - 2.3e-39 133.0 8.2 2.8e-39 132.7 8.2 1.1 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC89170.1 - 7e-40 134.6 9.2 8.4e-40 134.4 9.2 1.1 1 0 0 1 1 1 1 Keratin TIL PF01826.17 EMC89170.1 - 0.041 14.1 5.9 0.07 13.4 5.9 1.4 1 0 0 1 1 1 0 Trypsin Inhibitor like cysteine rich domain MFS18 PF17352.2 EMC89170.1 - 0.83 10.1 8.5 1.2 9.6 8.5 1.2 1 0 0 1 1 1 0 Male Flower Specific protein 18 Keratin PF02422.16 EMC89171.1 - 4.8e-42 141.6 7.7 5.3e-42 141.4 7.7 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC89172.1 - 1.6e-42 143.1 9.1 1.8e-42 143.0 9.1 1.0 1 0 0 1 1 1 1 Keratin CALCOCO1 PF07888.11 EMC89172.1 - 0.087 11.7 0.2 0.098 11.5 0.2 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Keratin PF02422.16 EMC89173.1 - 1.7e-42 143.0 9.4 1.9e-42 142.9 9.4 1.0 1 0 0 1 1 1 1 Keratin CALCOCO1 PF07888.11 EMC89173.1 - 0.087 11.7 0.2 0.098 11.5 0.2 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DX PF01666.17 EMC89174.1 - 9e-07 29.3 46.0 1.1 9.7 1.3 6.3 6 0 0 6 6 6 6 DX module FOLN PF09289.10 EMC89174.1 - 0.00027 21.0 26.8 12 6.1 0.3 6.9 6 0 0 6 6 6 6 Follistatin/Osteonectin-like EGF domain DUF4176 PF13780.6 EMC89174.1 - 0.0018 18.3 1.9 2.3e+02 1.9 0.0 5.5 6 0 0 6 6 6 0 Domain of unknown function (DUF4176) DUF1586 PF07625.11 EMC89174.1 - 0.0021 18.1 1.1 1.9e+02 2.2 0.0 5.4 6 0 0 6 6 6 0 Protein of unknown function (DUF1586) NHL PF01436.21 EMC89174.1 - 0.0024 17.8 17.8 38 4.6 0.1 6.4 6 0 0 6 6 6 0 NHL repeat TSP_1 PF00090.19 EMC89174.1 - 1.4 9.1 33.1 22 5.4 0.3 6.9 1 1 1 6 6 6 0 Thrombospondin type 1 domain Hydrophob_seed PF14547.6 EMC89174.1 - 1.7 8.9 29.8 3.3 8.0 1.4 5.0 1 1 4 5 5 5 0 Hydrophobic seed protein zinc_ribbon_16 PF17034.5 EMC89174.1 - 4.1 7.6 33.6 13 6.0 1.2 5.6 1 1 5 6 6 6 0 Zinc-ribbon like family COesterase PF00135.28 EMC89175.1 - 1.7e-83 281.2 0.0 1.9e-83 281.1 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family 7tm_4 PF13853.6 EMC89176.1 - 1.6e-43 149.5 14.9 1.9e-43 149.2 14.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC89176.1 - 5.8e-27 94.7 20.7 8.2e-27 94.2 20.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CBFB_NFYA PF02045.15 EMC89177.1 - 2e-27 95.6 8.7 3.2e-27 94.9 8.7 1.3 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B V-set PF07686.17 EMC89178.1 - 1.6e-09 37.9 0.6 2.2e-09 37.4 0.6 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC89178.1 - 0.014 15.9 0.5 0.041 14.5 0.5 1.8 1 1 0 1 1 1 0 Immunoglobulin domain ig PF00047.25 EMC89178.1 - 0.04 14.1 0.1 0.079 13.1 0.1 1.6 1 1 0 1 1 1 0 Immunoglobulin domain SIT PF15330.6 EMC89179.1 - 6.1e-05 23.4 0.0 9.8e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT TMEM154 PF15102.6 EMC89179.1 - 0.0015 18.5 0.0 0.0019 18.1 0.0 1.3 1 0 0 1 1 1 1 TMEM154 protein family PEP-CTERM PF07589.11 EMC89179.1 - 0.039 14.0 0.6 4.1 7.6 0.2 2.4 2 0 0 2 2 2 0 PEP-CTERM motif NCA2 PF08637.10 EMC89179.1 - 0.07 12.3 0.0 0.082 12.1 0.0 1.1 1 0 0 1 1 1 0 ATP synthase regulation protein NCA2 Gram_pos_anchor PF00746.21 EMC89179.1 - 0.094 12.7 0.2 0.2 11.6 0.2 1.6 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Herpes_gE PF02480.16 EMC89179.1 - 0.11 11.2 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E V-set PF07686.17 EMC89180.1 - 4.3e-23 81.6 8.4 3.9e-13 49.5 1.8 2.1 2 0 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.25 EMC89180.1 - 1.8e-07 31.2 5.7 0.0017 18.5 0.5 2.6 3 0 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.6 EMC89180.1 - 6.1e-07 29.9 5.0 0.0034 18.0 1.6 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC89180.1 - 3.2e-06 27.1 2.0 0.0068 16.4 0.3 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_6 PF18452.1 EMC89180.1 - 0.00028 20.4 0.4 0.76 9.4 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Izumo-Ig PF16706.5 EMC89180.1 - 0.0014 18.6 0.5 1.8 8.7 0.1 2.4 2 1 0 2 2 2 2 Izumo-like Immunoglobulin domain BACON PF13004.7 EMC89180.1 - 0.0045 17.0 2.3 0.11 12.5 0.4 3.0 2 1 1 3 3 3 1 Putative binding domain, N-terminal Ig_4 PF16680.5 EMC89180.1 - 0.013 15.7 0.7 2 8.7 0.1 2.4 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain Ig_2 PF13895.6 EMC89180.1 - 0.015 15.6 7.8 0.047 14.0 3.9 3.0 2 2 0 2 2 2 0 Immunoglobulin domain ATP-synt_S1 PF05827.12 EMC89180.1 - 0.07 13.0 1.9 0.1 12.4 0.0 2.2 2 1 1 3 3 3 0 Vacuolar ATP synthase subunit S1 (ATP6S1) Ig_Tie2_1 PF10430.9 EMC89180.1 - 0.32 11.4 3.6 0.3 11.5 0.2 2.1 2 0 0 2 2 2 0 Tie-2 Ig-like domain 1 CENP-T_C PF15511.6 EMC89181.1 - 1.8e-08 34.5 0.1 2.2e-08 34.2 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 EMC89181.1 - 2.5e-05 24.4 0.2 3.5e-05 23.9 0.2 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 EMC89181.1 - 4.6e-05 23.7 0.1 6.1e-05 23.3 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 EMC89181.1 - 0.00017 21.9 0.3 0.00019 21.8 0.3 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC89181.1 - 0.00028 21.1 0.1 0.00046 20.4 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EMC89181.1 - 0.0059 16.7 0.0 0.0067 16.5 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EMC89181.1 - 0.024 14.6 0.1 0.037 14.0 0.1 1.2 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 EMC89181.1 - 0.21 11.4 0.1 0.25 11.1 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) Histone PF00125.24 EMC89182.1 - 7e-54 181.7 2.3 7.8e-54 181.6 2.3 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EMC89182.1 - 9.3e-05 22.5 0.4 0.00015 21.8 0.0 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 EMC89182.1 - 0.0002 22.0 1.2 0.00023 21.7 1.2 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-S PF15630.6 EMC89182.1 - 0.00043 20.6 0.0 0.00065 20.0 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EMC89182.1 - 0.011 16.0 0.1 0.022 15.0 0.1 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EMC89182.1 - 0.1 12.6 0.1 0.21 11.6 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 EMC89183.1 - 6.8e-54 181.7 2.3 7.6e-54 181.6 2.3 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EMC89183.1 - 8.4e-05 22.6 0.3 0.00015 21.8 0.0 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 EMC89183.1 - 0.00019 22.0 1.2 0.00023 21.8 1.2 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-S PF15630.6 EMC89183.1 - 0.00042 20.6 0.0 0.00064 20.0 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EMC89183.1 - 0.011 16.0 0.1 0.022 15.0 0.1 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EMC89183.1 - 0.11 12.6 0.1 0.21 11.7 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 EMC89184.1 - 2e-08 34.3 0.1 2.4e-08 34.0 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 EMC89184.1 - 2.7e-05 24.2 0.2 3.9e-05 23.8 0.2 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 EMC89184.1 - 5.1e-05 23.6 0.1 6.8e-05 23.2 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 EMC89184.1 - 0.00019 21.8 0.3 0.00021 21.7 0.3 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC89184.1 - 0.0003 21.0 0.1 0.00048 20.4 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EMC89184.1 - 0.0065 16.5 0.0 0.0074 16.4 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EMC89184.1 - 0.027 14.5 0.1 0.04 13.9 0.1 1.2 1 0 0 1 1 1 0 Bromodomain associated Linker_histone PF00538.19 EMC89185.1 - 8.5e-22 77.3 0.7 8.5e-22 77.3 0.7 2.0 2 1 0 2 2 2 1 linker histone H1 and H5 family Histone PF00125.24 EMC89186.1 - 5.5e-26 91.5 0.6 6.4e-26 91.3 0.6 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC89186.1 - 9e-07 29.1 1.0 1.8e-06 28.1 0.0 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EMC89186.1 - 0.0033 17.9 0.0 0.0058 17.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 EMC89186.1 - 0.0036 17.4 0.2 0.0042 17.1 0.2 1.1 1 0 0 1 1 1 1 YscO-like protein Histone_H2A_C PF16211.5 EMC89187.1 - 2.9e-20 71.7 1.8 5e-20 70.9 1.8 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EMC89187.1 - 5e-17 62.5 0.0 6.5e-17 62.1 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC89187.1 - 1e-05 25.7 0.0 1.4e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.6 EMC89188.1 - 2e-08 34.3 0.1 2.5e-08 34.0 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 EMC89188.1 - 2.8e-05 24.2 0.2 3.9e-05 23.7 0.2 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 EMC89188.1 - 5.3e-05 23.5 0.1 6.9e-05 23.1 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 EMC89188.1 - 0.00019 21.8 0.3 0.00022 21.6 0.3 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC89188.1 - 0.00031 21.0 0.1 0.00049 20.3 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EMC89188.1 - 0.0066 16.5 0.0 0.0076 16.3 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EMC89188.1 - 0.027 14.5 0.1 0.041 13.9 0.1 1.2 1 0 0 1 1 1 0 Bromodomain associated Histone PF00125.24 EMC89189.1 - 6.6e-26 91.2 0.3 8.4e-26 90.9 0.3 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC89189.1 - 9.3e-07 29.1 1.0 1.6e-06 28.3 0.0 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EMC89189.1 - 0.003 18.0 0.0 0.0053 17.2 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 EMC89189.1 - 0.0052 16.8 0.1 0.0061 16.6 0.1 1.2 1 0 0 1 1 1 1 YscO-like protein Histone PF00125.24 EMC89190.1 - 6.8e-54 181.7 2.3 7.6e-54 181.6 2.3 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EMC89190.1 - 8.4e-05 22.6 0.3 0.00015 21.8 0.0 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 EMC89190.1 - 0.00019 22.0 1.2 0.00023 21.8 1.2 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-S PF15630.6 EMC89190.1 - 0.00042 20.6 0.0 0.00064 20.0 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EMC89190.1 - 0.011 16.0 0.1 0.022 15.0 0.1 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EMC89190.1 - 0.11 12.6 0.1 0.21 11.7 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 EMC89191.1 - 4.6e-26 91.7 0.3 5.6e-26 91.4 0.3 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC89191.1 - 9.5e-07 29.0 1.0 1.8e-06 28.1 0.0 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EMC89191.1 - 0.0034 17.8 0.0 0.006 17.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 EMC89191.1 - 0.0038 17.3 0.3 0.0045 17.0 0.3 1.1 1 0 0 1 1 1 1 YscO-like protein Histone_H2A_C PF16211.5 EMC89192.1 - 4.1e-20 71.2 1.1 7.1e-20 70.4 1.1 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EMC89192.1 - 2.7e-17 63.4 0.0 3.4e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC89192.1 - 3.3e-05 24.1 0.0 4.6e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Ribosomal_L27A PF00828.19 EMC89192.1 - 0.047 14.4 0.1 0.056 14.1 0.1 1.2 1 0 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A CENP-T_C PF15511.6 EMC89193.1 - 9.8e-09 35.3 0.0 1.2e-08 35.1 0.0 1.1 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 EMC89193.1 - 1.5e-05 25.1 0.1 1.9e-05 24.7 0.1 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 EMC89193.1 - 2.8e-05 24.4 0.1 3.6e-05 24.1 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 EMC89193.1 - 0.00011 22.6 0.0 0.00011 22.5 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC89193.1 - 0.00018 21.8 0.1 0.00023 21.4 0.1 1.4 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EMC89193.1 - 0.0034 17.5 0.0 0.0035 17.4 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EMC89193.1 - 0.014 15.3 0.1 0.02 14.9 0.1 1.2 1 0 0 1 1 1 0 Bromodomain associated TFIID_20kDa PF03847.13 EMC89193.1 - 0.16 12.5 0.0 0.26 11.8 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Histone PF00125.24 EMC89194.1 - 4.9e-25 88.4 2.1 2.5e-17 63.5 0.1 2.0 2 0 0 2 2 2 2 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EMC89194.1 - 0.018 15.4 0.0 0.024 15.0 0.0 1.2 1 0 0 1 1 1 0 CENP-S protein CENP-T_C PF15511.6 EMC89194.1 - 0.076 13.1 0.0 0.079 13.1 0.0 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EMC89195.1 - 6.8e-54 181.7 2.3 7.6e-54 181.6 2.3 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EMC89195.1 - 8.4e-05 22.6 0.3 0.00015 21.8 0.0 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 EMC89195.1 - 0.00019 22.0 1.2 0.00023 21.8 1.2 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-S PF15630.6 EMC89195.1 - 0.00042 20.6 0.0 0.00064 20.0 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EMC89195.1 - 0.011 16.0 0.1 0.022 15.0 0.1 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EMC89195.1 - 0.11 12.6 0.1 0.21 11.7 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 EMC89196.1 - 1.5e-08 34.8 0.1 1.7e-08 34.5 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 EMC89196.1 - 2e-05 24.6 0.1 2.9e-05 24.2 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 EMC89196.1 - 3.8e-05 24.0 0.1 5e-05 23.6 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 EMC89196.1 - 0.00015 22.1 0.3 0.00016 22.0 0.3 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC89196.1 - 0.00023 21.4 0.1 0.00039 20.7 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EMC89196.1 - 0.005 16.9 0.0 0.0056 16.7 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EMC89196.1 - 0.021 14.8 0.1 0.032 14.3 0.1 1.2 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 EMC89196.1 - 0.17 11.7 0.1 0.2 11.4 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) Histone PF00125.24 EMC89197.1 - 6.8e-26 91.2 0.2 8.4e-26 90.9 0.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMC89197.1 - 8.9e-07 29.1 0.7 1.8e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EMC89197.1 - 0.0031 18.0 0.0 0.006 17.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 EMC89197.1 - 0.0034 17.4 0.3 0.0039 17.2 0.3 1.2 1 0 0 1 1 1 1 YscO-like protein Linker_histone PF00538.19 EMC89198.1 - 9.5e-08 32.3 0.8 9.5e-08 32.3 0.8 1.6 2 1 0 2 2 2 1 linker histone H1 and H5 family Wbp11 PF09429.10 EMC89199.1 - 8.5e-22 77.3 13.8 8.5e-22 77.3 13.8 3.2 3 1 0 3 3 3 1 WW domain binding protein 11 DUF4533 PF15047.6 EMC89200.1 - 3.3e-64 216.6 10.1 1.9e-62 210.9 10.1 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF4533) DNA_repr_REX1B PF14966.6 EMC89200.1 - 0.034 14.8 4.5 0.097 13.3 0.9 2.4 2 1 1 3 3 3 0 DNA repair REX1-B PI3K_P85_iSH2 PF16454.5 EMC89200.1 - 0.077 12.6 4.7 0.29 10.7 1.2 2.2 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain IZUMO PF15005.6 EMC89200.1 - 0.083 13.4 3.7 6.5 7.3 0.5 2.9 1 1 2 3 3 3 0 Izumo sperm-egg fusion, Ig domain-associated Rit1_C PF17184.4 EMC89200.1 - 0.24 10.8 1.4 0.5 9.8 0.2 1.8 2 0 0 2 2 2 0 Rit1 N-terminal domain DUF2408 PF10303.9 EMC89200.1 - 0.77 10.3 5.5 1.3 9.5 1.4 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF2408) TTRAP PF14203.6 EMC89200.1 - 1.7 8.7 4.2 3.6 7.6 0.5 2.6 3 0 0 3 3 3 0 Putative tranposon-transfer assisting protein ART PF01129.18 EMC89201.1 - 9.7e-51 172.2 1.7 1.1e-50 172.0 1.7 1.0 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 EMC89201.1 - 0.012 15.0 0.0 0.017 14.5 0.0 1.4 1 0 0 1 1 1 0 ADP-ribosyltransferase exoenzyme zf-C4_Topoisom PF01396.19 EMC89202.1 - 0.14 12.0 1.6 0.23 11.3 0.5 1.9 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger Thioredoxin_6 PF13848.6 EMC89205.1 - 3.3e-24 85.8 0.3 3.8e-24 85.6 0.3 1.0 1 0 0 1 1 1 1 Thioredoxin-like domain Rho_GDI PF02115.17 EMC89206.1 - 3.9e-76 255.2 0.2 4.7e-76 254.9 0.2 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor PDE6_gamma PF04868.12 EMC89207.1 - 6.1e-47 157.8 0.9 6.7e-47 157.7 0.9 1.0 1 0 0 1 1 1 1 Retinal cGMP phosphodiesterase, gamma subunit Pepdidase_M14_N PF18027.1 EMC89208.1 - 1.3e-20 73.8 2.3 3.2e-20 72.5 2.3 1.7 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain Peptidase_M14 PF00246.24 EMC89208.1 - 1e-17 64.9 0.0 2.3e-17 63.7 0.0 1.6 1 1 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.14 EMC89208.1 - 0.00068 18.8 0.0 0.0012 18.0 0.0 1.4 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family TM140 PF14985.6 EMC89209.1 - 7.1e-26 90.8 0.8 8.4e-26 90.6 0.8 1.1 1 0 0 1 1 1 1 TM140 protein family Yae1_N PF09811.9 EMC89210.1 - 3.9e-06 26.5 20.3 2.8 7.7 12.5 4.2 2 1 0 2 2 2 2 Essential protein Yae1, N terminal Homeodomain PF00046.29 EMC89211.1 - 1.7e-08 34.1 1.1 2.1e-08 33.9 1.1 1.1 1 0 0 1 1 1 1 Homeodomain DUF1803 PF08820.10 EMC89211.1 - 0.005 16.8 0.1 0.0055 16.7 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1803) SPT_ssu-like PF11779.8 EMC89211.1 - 0.061 13.0 0.0 0.072 12.7 0.0 1.1 1 0 0 1 1 1 0 Small subunit of serine palmitoyltransferase-like DNA_pol_B PF00136.21 EMC89212.1 - 8.5e-131 436.8 2.1 1.2e-130 436.3 2.1 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EMC89212.1 - 8.2e-57 192.8 0.1 2.6e-56 191.2 0.1 1.9 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-DNA_Pol PF08996.10 EMC89212.1 - 3.4e-55 186.7 8.2 6.4e-55 185.8 8.2 1.5 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_alpha_N PF12254.8 EMC89212.1 - 7.3e-16 58.0 12.2 7.3e-16 58.0 12.2 2.7 3 0 0 3 3 3 1 DNA polymerase alpha subunit p180 N terminal DUF1744 PF08490.12 EMC89212.1 - 0.00024 19.8 0.5 0.0011 17.6 0.5 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1744) DNA_pol_B_2 PF03175.13 EMC89212.1 - 0.00045 19.2 0.4 0.0039 16.1 0.0 2.4 2 0 0 2 2 2 1 DNA polymerase type B, organellar and viral tRNA-synt_1g PF09334.11 EMC89212.1 - 0.073 11.8 5.8 2.2 6.9 1.0 2.5 2 0 0 2 2 2 0 tRNA synthetases class I (M) CTP_transf_like PF01467.26 EMC89213.1 - 1.7e-32 112.6 0.4 3.4e-32 111.6 0.0 1.6 2 0 0 2 2 2 1 Cytidylyltransferase-like Lipoprotein_6 PF01441.19 EMC89213.1 - 0.06 13.3 1.9 0.1 12.6 1.9 1.3 1 0 0 1 1 1 0 Lipoprotein YtxH PF12732.7 EMC89213.1 - 0.11 13.0 2.0 0.22 12.1 2.0 1.5 1 0 0 1 1 1 0 YtxH-like protein BCDHK_Adom3 PF10436.9 EMC89214.1 - 7.6e-46 155.9 0.0 1.1e-45 155.3 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EMC89214.1 - 2.8e-13 50.4 0.0 4.4e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EMC89214.1 - 0.0077 16.1 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Solute_trans_a PF03619.16 EMC89215.1 - 4.4e-32 111.6 15.9 7e-32 111.0 15.9 1.2 1 0 0 1 1 1 1 Organic solute transporter Ostalpha DUF2427 PF10348.9 EMC89215.1 - 0.094 12.5 10.0 0.17 11.7 0.9 3.7 2 1 2 4 4 4 0 Domain of unknown function (DUF2427) Zfx_Zfy_act PF04704.13 EMC89216.1 - 2.7e-151 503.3 18.1 2.7e-151 503.3 18.1 1.6 2 0 0 2 2 2 1 Zfx / Zfy transcription activation region zf-C2H2 PF00096.26 EMC89216.1 - 1e-42 142.2 116.5 1e-05 25.7 2.1 13.4 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC89216.1 - 3e-38 128.5 122.1 2.7e-08 33.9 1.2 13.7 14 0 0 14 14 13 12 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC89216.1 - 2.7e-32 108.7 111.1 0.00016 22.2 0.9 13.4 13 0 0 13 13 13 13 C2H2-type zinc finger zf-H2C2_5 PF13909.6 EMC89216.1 - 5.1e-26 90.1 105.1 4.4e-07 29.5 5.8 12.6 12 1 0 12 12 12 8 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 EMC89216.1 - 1.3e-11 44.5 74.7 0.028 14.7 0.1 12.3 13 0 0 13 13 12 7 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.5 EMC89216.1 - 4.2e-08 33.8 47.8 0.031 15.0 2.2 7.3 4 2 3 7 7 7 5 zinc-ribbon family zf-C2H2_3rep PF18868.1 EMC89216.1 - 0.0018 18.9 44.9 0.36 11.5 6.8 7.7 2 1 3 7 7 7 4 Zinc finger C2H2-type, 3 repeats zf-BED PF02892.15 EMC89216.1 - 0.0049 16.8 2.5 0.0049 16.8 2.5 10.0 4 3 7 11 11 11 5 BED zinc finger zf-C2H2_11 PF16622.5 EMC89216.1 - 0.021 14.6 0.2 0.021 14.6 0.2 10.2 13 0 0 13 13 13 0 zinc-finger C2H2-type zf-met PF12874.7 EMC89216.1 - 0.15 12.5 0.0 0.15 12.5 0.0 11.4 12 1 1 13 13 12 0 Zinc-finger of C2H2 type zf-RING_7 PF02591.15 EMC89216.1 - 3 8.1 11.5 27 5.1 0.1 5.7 5 0 0 5 5 5 0 C4-type zinc ribbon domain eIF2_C PF09173.11 EMC89217.1 - 5.9e-37 125.8 2.2 6.5e-37 125.7 0.5 2.0 2 0 0 2 2 2 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 EMC89217.1 - 4.6e-23 81.8 1.1 4.1e-22 78.7 1.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EMC89217.1 - 5.9e-13 49.0 0.3 1.7e-12 47.5 0.3 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 EMC89217.1 - 0.0031 17.4 0.4 0.025 14.5 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 EMC89217.1 - 0.0032 17.5 0.0 0.0067 16.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 EMC89217.1 - 0.014 15.4 0.1 0.028 14.4 0.1 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain G-alpha PF00503.20 EMC89217.1 - 0.12 11.5 0.1 0.83 8.7 0.0 1.9 2 0 0 2 2 2 0 G-protein alpha subunit Dynamin_N PF00350.23 EMC89217.1 - 0.13 12.3 0.2 0.53 10.3 0.2 2.0 1 1 0 1 1 1 0 Dynamin family Kelch_1 PF01344.25 EMC89218.1 - 9.7e-41 137.1 7.4 3e-11 42.7 0.1 5.4 5 0 0 5 5 5 5 Kelch motif Kelch_6 PF13964.6 EMC89218.1 - 2.1e-34 116.7 4.2 1.5e-08 34.6 0.2 6.1 3 2 2 5 5 5 5 Kelch motif BTB PF00651.31 EMC89218.1 - 1.5e-23 83.2 1.9 1.5e-23 83.2 1.9 2.2 3 0 0 3 3 3 1 BTB/POZ domain Kelch_4 PF13418.6 EMC89218.1 - 6e-20 71.0 2.4 0.0049 16.9 0.0 5.9 5 1 0 5 5 5 5 Galactose oxidase, central domain Kelch_3 PF13415.6 EMC89218.1 - 1.4e-17 63.5 0.6 0.00014 22.1 0.1 5.7 5 2 0 5 5 5 4 Galactose oxidase, central domain BACK PF07707.15 EMC89218.1 - 7.1e-16 58.2 0.9 9.7e-16 57.8 0.1 1.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_2 PF07646.15 EMC89218.1 - 2.4e-14 52.7 11.4 0.0012 18.8 0.0 6.1 6 1 0 6 6 6 4 Kelch motif Kelch_5 PF13854.6 EMC89218.1 - 1.8e-08 34.2 8.6 0.062 13.3 0.0 5.3 5 0 0 5 5 5 4 Kelch motif ApoO PF09769.9 EMC89219.1 - 1.3e-40 138.4 0.0 1.8e-40 137.9 0.0 1.1 1 0 0 1 1 1 1 Apolipoprotein O Acetyltransf_1 PF00583.25 EMC89220.1 - 3.7e-17 62.6 0.1 4.6e-17 62.3 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EMC89220.1 - 4.2e-08 33.5 0.0 7e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EMC89220.1 - 4.3e-05 23.5 0.0 5.1e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMC89220.1 - 0.00052 19.9 0.0 0.0012 18.8 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 EMC89220.1 - 0.0031 18.2 0.0 0.0039 17.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EMC89220.1 - 0.0097 16.0 0.0 0.084 13.0 0.0 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain 4HBT PF03061.22 EMC89221.1 - 1.8e-08 34.6 0.0 0.0042 17.4 0.0 2.3 2 0 0 2 2 2 2 Thioesterase superfamily Patched PF02460.18 EMC89222.1 - 1.5e-96 324.3 23.0 2.6e-96 323.5 23.0 1.3 1 1 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 EMC89222.1 - 2.1e-19 69.9 1.6 2.1e-19 69.9 1.6 2.5 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Peptidase_M13_N PF05649.13 EMC89223.1 - 1.4e-109 367.3 2.2 1.8e-109 367.0 2.2 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 EMC89223.1 - 4.2e-65 219.2 0.8 5.8e-65 218.7 0.1 1.6 2 0 0 2 2 2 1 Peptidase family M13 SpmSyn_N PF17950.1 EMC89224.1 - 5e-51 170.9 0.1 9.4e-51 170.0 0.1 1.5 1 0 0 1 1 1 1 S-adenosylmethionine decarboxylase N -terminal Spermine_synth PF01564.17 EMC89224.1 - 4.6e-45 153.3 0.1 7.3e-45 152.7 0.1 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 EMC89224.1 - 2.9e-18 65.5 0.0 6e-18 64.5 0.0 1.5 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Citrate_bind PF16114.5 EMC89224.1 - 0.026 14.0 0.0 0.31 10.5 0.0 2.1 2 0 0 2 2 2 0 ATP citrate lyase citrate-binding Peptidase_M50 PF02163.22 EMC89225.1 - 1.1e-31 110.0 1.1 3.2e-30 105.2 0.2 2.3 2 0 0 2 2 2 2 Peptidase family M50 PDZ_2 PF13180.6 EMC89225.1 - 0.0081 16.5 0.0 0.016 15.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Chisel PF15355.6 EMC89226.1 - 8.9e-48 160.5 3.7 9.9e-48 160.3 3.7 1.0 1 0 0 1 1 1 1 Stretch-responsive small skeletal muscle X protein, Chisel Kelch_1 PF01344.25 EMC89227.1 - 2.2e-37 126.4 0.5 3.3e-10 39.4 0.0 6.0 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 EMC89227.1 - 1.4e-31 107.7 4.7 4e-07 30.1 0.0 6.4 3 3 3 6 6 6 4 Kelch motif Kelch_4 PF13418.6 EMC89227.1 - 5.4e-26 90.3 1.2 6.1e-07 29.4 0.0 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain BTB PF00651.31 EMC89227.1 - 1.6e-25 89.5 0.6 3.2e-25 88.5 0.6 1.6 1 0 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.6 EMC89227.1 - 1.5e-18 66.6 0.8 0.0036 17.5 0.0 6.7 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_2 PF07646.15 EMC89227.1 - 6.9e-14 51.2 5.4 4.2e-06 26.5 0.0 5.4 5 2 0 5 5 5 3 Kelch motif BACK PF07707.15 EMC89227.1 - 2.4e-12 46.9 0.2 5.2e-12 45.8 0.2 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_5 PF13854.6 EMC89227.1 - 5e-09 35.9 5.9 0.075 13.0 0.0 6.0 6 0 0 6 6 6 3 Kelch motif DUF1170 PF06663.13 EMC89228.1 - 1.3e-62 211.3 13.6 1.5e-62 211.1 9.1 3.1 3 1 0 3 3 3 1 Protein of unknown function (DUF1170) CRIC_ras_sig PF10534.9 EMC89228.1 - 4e-31 107.0 2.0 1.1e-29 102.4 0.7 3.1 2 1 0 2 2 2 1 Connector enhancer of kinase suppressor of ras SAM_1 PF00536.30 EMC89228.1 - 2e-15 57.0 1.8 7.4e-15 55.2 0.3 2.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PH PF00169.29 EMC89228.1 - 5.6e-15 55.7 5.5 1.5e-14 54.3 4.2 2.4 2 0 0 2 2 2 1 PH domain SAM_2 PF07647.17 EMC89228.1 - 5.1e-10 39.3 0.7 3.3e-09 36.7 0.3 2.4 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PDZ PF00595.24 EMC89228.1 - 5.3e-09 36.3 0.1 1.5e-08 34.9 0.0 1.8 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 EMC89228.1 - 3.7e-08 33.1 0.0 1e-07 31.7 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC89228.1 - 0.0032 17.8 0.1 0.034 14.5 0.0 2.4 2 0 0 2 2 2 1 PDZ domain PH_9 PF15410.6 EMC89228.1 - 0.0037 17.6 5.2 0.15 12.4 2.9 3.5 4 1 0 4 4 3 1 Pleckstrin homology domain ATG11 PF10377.9 EMC89228.1 - 0.028 14.5 0.7 0.079 13.0 0.7 1.7 1 0 0 1 1 1 0 Autophagy-related protein 11 PH_13 PF16652.5 EMC89228.1 - 0.44 10.4 4.0 0.15 11.8 0.2 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain PH_11 PF15413.6 EMC89228.1 - 1.5 9.3 18.1 0.11 12.9 10.6 3.0 3 1 0 3 3 2 0 Pleckstrin homology domain Opi1 PF08618.10 EMC89228.1 - 1.8 7.8 6.7 0.21 10.8 2.1 1.7 2 0 0 2 2 2 0 Transcription factor Opi1 eIF-1a PF01176.19 EMC89229.1 - 1.4e-21 76.0 0.1 1.8e-21 75.7 0.1 1.1 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 MAP7 PF05672.11 EMC89230.1 - 4.1e-47 159.9 88.6 4.1e-47 159.9 88.6 3.4 3 0 0 3 3 3 1 MAP7 (E-MAP-115) family THRAP3_BCLAF1 PF15440.6 EMC89231.1 - 1.8e-78 265.2 12.1 2e-78 265.1 12.1 1.0 1 0 0 1 1 1 1 THRAP3/BCLAF1 family PDCD7 PF16021.5 EMC89231.1 - 0.014 14.5 0.3 0.019 14.1 0.3 1.1 1 0 0 1 1 1 0 Programmed cell death protein 7 Pentapeptide_2 PF01469.18 EMC89232.1 - 0.019 14.8 0.1 0.036 14.0 0.1 1.4 1 0 0 1 1 1 0 Pentapeptide repeats (8 copies) Histone PF00125.24 EMC89233.1 - 4.4e-18 65.9 0.0 5.3e-18 65.6 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EMC89233.1 - 1.9e-13 49.9 0.5 3.6e-13 49.0 0.5 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A Vps35 PF03635.17 EMC89235.1 - 5.9e-302 1003.7 13.1 6.8e-302 1003.5 13.1 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 FerA PF08165.11 EMC89235.1 - 0.052 13.5 0.1 0.27 11.2 0.1 2.2 1 0 0 1 1 1 0 FerA (NUC095) domain Imm5 PF14423.6 EMC89235.1 - 0.26 11.5 1.2 1.5 9.0 0.2 2.4 2 0 0 2 2 2 0 Immunity protein Imm5 ORC6 PF05460.13 EMC89236.1 - 7.5e-11 41.9 12.3 9.1e-10 38.3 1.1 3.0 2 1 1 3 3 3 3 Origin recognition complex subunit 6 (ORC6) Pkinase PF00069.25 EMC89237.1 - 3.5e-73 246.2 0.1 4.2e-73 245.9 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC89237.1 - 1.3e-40 139.3 0.0 1.7e-40 139.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC89237.1 - 4.1e-06 26.3 0.0 5.6e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC89237.1 - 0.0023 17.3 0.4 0.0038 16.6 0.4 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMC89237.1 - 0.088 12.7 0.1 0.38 10.6 0.1 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family UPF0547 PF10571.9 EMC89238.1 - 1.8e-05 24.7 2.8 2.7e-05 24.1 2.8 1.3 1 0 0 1 1 1 1 Uncharacterised protein family UPF0547 Sec62 PF03839.16 EMC89238.1 - 0.39 10.2 4.0 0.43 10.1 4.0 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Zip PF02535.22 EMC89238.1 - 0.47 9.6 2.3 0.52 9.5 2.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 EMC89238.1 - 0.9 8.2 5.9 1 8.0 5.9 1.0 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 EMC89238.1 - 1.3 9.0 4.2 1.6 8.7 4.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Transformer PF06495.11 EMC89238.1 - 3.7 7.6 16.9 5 7.2 16.9 1.1 1 0 0 1 1 1 0 Fruit fly transformer protein Hid1 PF12722.7 EMC89238.1 - 5 5.1 7.4 5.8 4.9 7.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDC45 PF02724.14 EMC89238.1 - 8.3 4.6 10.8 9.6 4.4 10.8 1.0 1 0 0 1 1 1 0 CDC45-like protein TPR_4 PF07721.14 EMC89239.1 - 4.4e-10 39.2 4.1 2.2e+02 2.9 0.0 10.7 10 0 0 10 10 10 0 Tetratricopeptide repeat Ly-6_related PF06579.12 EMC89239.1 - 6.9e-09 36.0 5.8 1e+02 3.2 0.2 9.0 9 0 0 9 9 9 0 Caenorhabditis elegans ly-6-related protein zf-RING_6 PF14835.6 EMC89239.1 - 0.0019 18.0 36.5 26 4.8 0.1 10.5 11 0 0 11 11 11 9 zf-RING of BARD1-type protein Aminotran_1_2 PF00155.21 EMC89240.1 - 2.1e-30 106.1 0.0 2.4e-30 105.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Borealin PF10512.9 EMC89241.1 - 2.2e-06 27.6 0.1 2.5e-06 27.4 0.1 1.1 1 0 0 1 1 1 1 Cell division cycle-associated protein 8 DnaJ_C PF01556.18 EMC89242.1 - 3e-38 131.2 0.4 3.6e-38 131.0 0.4 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 EMC89242.1 - 0.068 13.5 1.8 0.14 12.6 1.8 1.5 1 0 0 1 1 1 0 DnaJ central domain CUB PF00431.20 EMC89243.1 - 3.2e-41 140.1 0.2 1.6e-26 92.8 0.0 3.1 3 0 0 3 3 3 2 CUB domain Ldl_recept_a PF00057.18 EMC89243.1 - 1.9e-06 27.9 3.4 1.9e-06 27.9 3.4 2.5 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A Arm_vescicular PF18770.1 EMC89243.1 - 0.042 13.8 0.1 0.1 12.6 0.1 1.6 1 0 0 1 1 1 0 Armadillo tether-repeat of vescicular transport factor Collagen PF01391.18 EMC89244.1 - 0.42 10.4 8.7 1.6 8.6 8.7 1.9 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) Glyco_hydro_15 PF00723.21 EMC89245.1 - 2.4e-115 385.9 0.0 3.1e-115 385.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Lon_C PF05362.13 EMC89246.1 - 2.4e-79 265.7 0.0 3.7e-79 265.0 0.0 1.3 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 EMC89246.1 - 1e-21 77.8 0.0 2.7e-21 76.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) LON_substr_bdg PF02190.16 EMC89246.1 - 8.3e-19 68.3 0.7 1.3e-18 67.6 0.1 1.6 2 0 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA_5 PF07728.14 EMC89246.1 - 1e-08 35.3 0.0 2.9e-08 33.8 0.0 1.8 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 EMC89246.1 - 6e-06 26.1 0.0 1.4e-05 25.0 0.0 1.6 1 1 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.6 EMC89246.1 - 2.3e-05 24.9 0.2 0.00043 20.7 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_3 PF07726.11 EMC89246.1 - 0.00046 20.1 0.0 0.001 18.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EMC89246.1 - 0.0014 18.9 0.9 0.019 15.2 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA_2 PF07724.14 EMC89246.1 - 0.0027 17.8 0.0 0.0076 16.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_PrkA PF08298.11 EMC89246.1 - 0.0035 16.3 0.0 0.032 13.1 0.0 2.1 2 0 0 2 2 2 1 PrkA AAA domain RsgA_GTPase PF03193.16 EMC89246.1 - 0.0099 15.8 0.0 0.024 14.5 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_18 PF13238.6 EMC89246.1 - 0.013 16.0 0.0 0.043 14.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EMC89246.1 - 0.021 14.6 0.0 0.073 12.8 0.0 1.9 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EMC89246.1 - 0.024 14.8 0.5 0.15 12.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EMC89246.1 - 0.042 13.8 0.0 0.087 12.7 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain SKI PF01202.22 EMC89246.1 - 0.048 13.8 0.6 0.1 12.7 0.1 1.8 2 0 0 2 2 2 0 Shikimate kinase IstB_IS21 PF01695.17 EMC89246.1 - 0.064 13.0 0.1 0.15 11.8 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein Sina PF03145.16 EMC89247.1 - 1.3e-88 296.2 0.1 2e-88 295.6 0.1 1.2 1 0 0 1 1 1 1 Seven in absentia protein family RNase_Zc3h12a PF11977.8 EMC89248.1 - 7.1e-54 181.8 0.0 2.1e-53 180.3 0.0 1.8 2 0 0 2 2 2 1 Zc3h12a-like Ribonuclease NYN domain UBA_6 PF18039.1 EMC89248.1 - 0.00073 19.4 0.3 0.0019 18.1 0.0 1.9 2 0 0 2 2 2 1 UBA-like domain DUF4392 PF14336.6 EMC89248.1 - 0.045 13.2 0.0 0.084 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4392) Peptidase_M16_C PF05193.21 EMC89249.1 - 0.14 12.2 0.1 0.29 11.1 0.0 1.5 2 0 0 2 2 2 0 Peptidase M16 inactive domain C1q PF00386.21 EMC89250.1 - 1.4e-08 35.0 0.0 1.5e-08 34.9 0.0 1.0 1 0 0 1 1 1 1 C1q domain zf-C2H2_4 PF13894.6 EMC89251.1 - 4e-67 217.0 215.3 0.00038 21.0 1.7 31.1 31 0 0 31 31 31 27 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC89251.1 - 6.2e-56 183.9 215.2 0.00031 21.0 1.4 30.8 31 0 0 31 31 31 21 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC89251.1 - 2.2e-26 91.0 186.7 0.00028 21.2 2.9 29.9 30 0 0 30 30 30 14 Zinc-finger double domain zf-Di19 PF05605.12 EMC89251.1 - 2e-22 79.2 184.5 0.00027 21.2 2.5 19.8 17 4 6 23 23 23 13 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 EMC89251.1 - 1.5e-21 75.8 170.8 1.5e-05 24.9 0.9 26.1 26 1 1 27 27 27 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC89251.1 - 6.2e-18 64.6 170.1 0.0095 16.2 0.8 27.2 27 2 1 28 28 28 13 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EMC89251.1 - 2.4e-05 24.6 172.3 0.37 11.1 4.9 24.5 7 5 9 19 19 19 8 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 EMC89251.1 - 0.00016 22.3 114.3 0.0013 19.4 8.1 16.8 8 5 6 14 14 14 4 Zinc finger C2H2-type, 3 repeats zf-met PF12874.7 EMC89251.1 - 0.00032 21.0 15.8 0.0023 18.3 2.1 22.7 27 0 0 27 27 26 8 Zinc-finger of C2H2 type C1_4 PF07975.12 EMC89251.1 - 0.028 14.6 0.8 0.028 14.6 0.8 19.5 14 3 9 24 24 23 0 TFIIH C1-like domain Zf_RING PF16744.5 EMC89251.1 - 0.029 14.5 0.6 0.029 14.5 0.6 12.8 12 4 3 16 16 16 0 KIAA1045 RING finger zf-C2H2_9 PF16293.5 EMC89251.1 - 0.089 12.7 0.0 0.089 12.7 0.0 17.3 17 4 4 21 21 21 0 C2H2 type zinc-finger (1 copy) Zn-C2H2_12 PF18112.1 EMC89251.1 - 0.11 13.0 0.2 0.11 13.0 0.2 14.2 15 0 0 15 15 14 0 Autophagy receptor zinc finger-C2H2 domain zf-C2HE PF16278.5 EMC89251.1 - 0.55 10.7 0.0 0.1 13.0 0.6 21.6 14 5 8 22 22 20 0 C2HE / C2H2 / C2HC zinc-binding finger Tmemb_18A PF09771.9 EMC89253.1 - 2.8e-56 189.0 0.1 3.1e-56 188.9 0.1 1.0 1 0 0 1 1 1 1 Transmembrane protein 188 DUF418 PF04235.12 EMC89253.1 - 0.029 14.3 0.2 0.032 14.2 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF418) DUF35_N PF12172.8 EMC89253.1 - 0.1 12.5 0.0 6.3 6.8 0.0 3.1 4 0 0 4 4 4 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DUF5392 PF17370.2 EMC89253.1 - 0.19 11.8 0.1 0.23 11.5 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5392) HEAT_EZ PF13513.6 EMC89254.1 - 1.3e-08 35.2 3.8 9.4e-07 29.2 0.5 4.4 3 2 1 4 4 4 1 HEAT-like repeat HEAT_2 PF13646.6 EMC89254.1 - 3.8e-07 30.4 0.7 0.0088 16.4 0.0 3.4 2 1 0 2 2 2 2 HEAT repeats HEAT PF02985.22 EMC89254.1 - 4.4e-06 26.5 6.8 0.38 11.1 0.0 5.2 4 0 0 4 4 4 2 HEAT repeat Arm PF00514.23 EMC89254.1 - 0.0059 16.6 0.2 0.0059 16.6 0.2 5.8 7 1 2 9 9 9 1 Armadillo/beta-catenin-like repeat TAF6_C PF07571.13 EMC89254.1 - 0.0094 16.2 0.0 0.055 13.8 0.0 2.4 2 0 0 2 2 2 1 TAF6 C-terminal HEAT repeat domain Cnd1 PF12717.7 EMC89254.1 - 0.034 14.2 0.4 0.24 11.4 0.0 2.7 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 NTP_transf_2 PF01909.23 EMC89255.1 - 1.8e-16 60.2 0.1 4.4e-16 58.9 0.1 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 EMC89255.1 - 4.9e-15 55.5 0.1 1.5e-14 53.9 0.0 1.9 2 0 0 2 2 2 1 Cid1 family poly A polymerase Polbeta PF18765.1 EMC89255.1 - 0.00053 20.0 0.0 0.0013 18.8 0.0 1.7 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase EF-hand_7 PF13499.6 EMC89256.1 - 0.00087 19.7 0.1 0.0032 17.9 0.1 2.1 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EMC89256.1 - 0.003 17.4 0.0 0.0072 16.2 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 EMC89256.1 - 0.0089 15.5 0.0 0.022 14.3 0.0 1.7 1 0 0 1 1 1 1 EF hand Nitroreductase PF00881.24 EMC89256.1 - 0.011 15.8 0.1 0.12 12.4 0.0 2.2 2 1 0 2 2 2 0 Nitroreductase family PX PF00787.24 EMC89257.1 - 9.5e-17 61.0 5.3 9.9e-16 57.7 3.9 2.8 2 1 1 3 3 3 1 PX domain TPR_12 PF13424.6 EMC89257.1 - 0.0033 17.7 0.0 0.0065 16.7 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat Ocnus PF05005.15 EMC89257.1 - 0.022 14.9 0.2 0.22 11.7 0.0 2.1 2 0 0 2 2 2 0 Janus/Ocnus family (Ocnus) MHC_I PF00129.18 EMC89257.1 - 0.069 12.7 0.1 4.6 6.8 0.0 2.3 2 0 0 2 2 2 0 Class I Histocompatibility antigen, domains alpha 1 and 2 CYLD_phos_site PF16607.5 EMC89258.1 - 1.1e-85 285.5 7.8 1.6e-85 285.0 7.8 1.2 1 0 0 1 1 1 1 Phosphorylation region of CYLD, unstructured CAP_GLY PF01302.25 EMC89258.1 - 5.3e-36 122.5 2.2 7.4e-15 54.7 0.0 3.4 3 0 0 3 3 3 3 CAP-Gly domain UCH PF00443.29 EMC89258.1 - 5.8e-09 35.8 0.2 1.1e-08 34.9 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase COX_ARM PF06481.14 EMC89258.1 - 0.096 12.6 0.0 0.26 11.2 0.0 1.7 1 0 0 1 1 1 0 COX Aromatic Rich Motif HMG_box PF00505.19 EMC89259.1 - 5.6e-18 65.1 0.3 1.6e-17 63.6 0.3 1.9 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC89259.1 - 7.2e-12 45.7 0.5 7.2e-12 45.7 0.5 2.5 2 1 0 2 2 2 1 HMG-box domain PA-IL PF07828.12 EMC89259.1 - 0.066 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 PA-IL-like protein IMUP PF15761.5 EMC89259.1 - 0.2 12.3 11.8 0.1 13.3 8.5 2.2 2 0 0 2 2 2 0 Immortalisation up-regulated protein Exonuc_VII_L PF02601.15 EMC89259.1 - 7.3 6.1 35.2 0.43 10.1 27.2 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit UQ_con PF00179.26 EMC89260.1 - 3e-23 82.0 0.0 5.2e-23 81.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme C2-C2_1 PF11618.8 EMC89261.1 - 1.1e-63 213.5 7.2 5.4e-54 182.1 0.8 4.6 5 0 0 5 5 5 3 First C2 domain of RPGR-interacting protein 1 RPGR1_C PF18111.1 EMC89261.1 - 1.9e-56 190.5 0.2 1.9e-56 190.5 0.2 2.3 3 0 0 3 3 3 1 Retinitis pigmentosa G-protein regulator interacting C-terminal C2 PF00168.30 EMC89261.1 - 7.4e-09 35.8 0.1 3.6e-08 33.6 0.0 2.3 2 1 1 3 3 3 1 C2 domain IFT46_B_C PF12317.8 EMC89261.1 - 0.03 14.1 1.7 0.063 13.0 1.7 1.6 1 0 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal Trehalose_PPase PF02358.16 EMC89261.1 - 0.084 12.0 0.2 0.2 10.8 0.2 1.5 1 0 0 1 1 1 0 Trehalose-phosphatase Bap31_Bap29_C PF18035.1 EMC89261.1 - 0.23 11.5 1.6 0.53 10.3 1.6 1.5 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain FTO_NTD PF12933.7 EMC89262.1 - 4.1e-122 406.9 0.0 5.3e-122 406.6 0.0 1.1 1 0 0 1 1 1 1 FTO catalytic domain FTO_CTD PF12934.7 EMC89262.1 - 2.4e-42 144.6 5.8 4.7e-42 143.6 5.8 1.5 1 0 0 1 1 1 1 FTO C-terminal domain Homeobox_KN PF05920.11 EMC89263.1 - 2.9e-17 62.3 0.4 4.2e-17 61.7 0.4 1.3 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EMC89263.1 - 1.9e-08 34.0 0.4 2.4e-08 33.7 0.4 1.1 1 0 0 1 1 1 1 Homeodomain MRP-S32 PF10210.9 EMC89263.1 - 0.0076 16.8 1.2 0.0087 16.6 1.2 1.1 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S32 Homez PF11569.8 EMC89263.1 - 0.042 13.3 0.0 0.11 12.0 0.0 1.7 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.11 EMC89265.1 - 2.9e-17 62.3 0.4 4.1e-17 61.8 0.4 1.2 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EMC89265.1 - 1.2e-08 34.6 0.8 1.5e-08 34.4 0.8 1.1 1 0 0 1 1 1 1 Homeodomain MRP-S32 PF10210.9 EMC89265.1 - 0.021 15.4 0.8 0.026 15.1 0.8 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S32 Homez PF11569.8 EMC89265.1 - 0.07 12.6 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.11 EMC89266.1 - 1.1e-17 63.6 0.3 1.7e-17 63.0 0.3 1.3 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EMC89266.1 - 1.1e-08 34.8 1.9 1.4e-08 34.5 1.9 1.1 1 0 0 1 1 1 1 Homeodomain MRP-S32 PF10210.9 EMC89266.1 - 0.021 15.4 2.1 0.025 15.1 2.1 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S32 Homez PF11569.8 EMC89266.1 - 0.057 12.9 0.0 0.11 12.0 0.0 1.6 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez Peptidase_M10 PF00413.24 EMC89267.1 - 8.5e-69 230.4 0.0 2.8e-68 228.8 0.0 1.9 1 1 0 1 1 1 1 Matrixin fn2 PF00040.19 EMC89267.1 - 1.9e-50 168.9 41.9 1.4e-17 63.7 4.2 4.1 4 0 0 4 4 4 3 Fibronectin type II domain Hemopexin PF00045.19 EMC89267.1 - 3.6e-41 138.8 8.9 4.2e-12 45.8 0.6 4.6 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.18 EMC89267.1 - 3.1e-08 33.7 0.0 7.7e-08 32.4 0.0 1.8 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.24 EMC89267.1 - 0.014 15.0 0.0 4.1 7.0 0.0 2.5 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.6 EMC89267.1 - 0.029 14.9 0.0 0.056 14.0 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EMC89267.1 - 0.053 13.7 0.0 0.093 12.9 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 EMC89267.1 - 0.087 12.5 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 EMC89267.1 - 0.12 11.3 0.1 0.19 10.7 0.1 1.2 1 0 0 1 1 1 0 Peptidase M66 Sulfotransfer_1 PF00685.27 EMC89268.1 - 1.2e-25 90.5 0.3 1.7e-25 90.0 0.3 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC89268.1 - 2.2e-17 64.2 0.8 6.1e-10 39.9 0.0 3.1 2 1 1 3 3 3 2 Sulfotransferase family TM231 PF10149.9 EMC89269.1 - 1.4e-108 362.8 0.0 2.1e-108 362.2 0.0 1.3 1 1 0 1 1 1 1 Transmembrane protein 231 Atg8 PF02991.16 EMC89270.1 - 2.5e-50 169.0 0.1 2.8e-50 168.8 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EMC89270.1 - 3.2e-06 27.5 0.0 3.6e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 tRNA-synt_2 PF00152.20 EMC89271.1 - 1.4e-77 260.8 0.1 1.9e-77 260.4 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EMC89271.1 - 2.1e-16 59.6 0.1 8e-16 57.8 0.0 2.0 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EMC89271.1 - 1.5e-07 31.2 0.1 0.0094 15.5 0.0 2.5 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) Rap1_C PF11626.8 EMC89272.1 - 1.5e-10 41.0 0.2 2.8e-10 40.1 0.0 1.5 2 0 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Sulfotransfer_1 PF00685.27 EMC89273.1 - 2.2e-26 93.0 0.0 3.1e-26 92.4 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC89273.1 - 1.8e-17 64.4 0.2 3.5e-10 40.6 0.0 2.7 2 1 0 2 2 2 2 Sulfotransferase family Aminotran_1_2 PF00155.21 EMC89274.1 - 1.5e-74 251.4 0.0 1.7e-74 251.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II TAT_ubiq PF07706.12 EMC89274.1 - 1.5e-17 63.5 0.8 2.4e-17 62.9 0.8 1.4 1 0 0 1 1 1 1 Aminotransferase ubiquitination site Aminotran_5 PF00266.19 EMC89274.1 - 3.7e-06 26.1 0.0 5.5e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EMC89274.1 - 1.9e-05 24.1 0.0 3e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 EMC89274.1 - 3e-05 23.4 0.0 4.5e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 EMC89274.1 - 0.0021 16.7 0.0 0.0032 16.0 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_MocR PF12897.7 EMC89274.1 - 0.076 11.8 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase MARVEL PF01284.23 EMC89275.1 - 4.3e-06 26.8 4.2 5.6e-06 26.4 4.2 1.2 1 0 0 1 1 1 1 Membrane-associating domain Phage_holin_3_6 PF07332.11 EMC89275.1 - 5.4 7.1 13.0 13 5.8 7.7 2.5 2 1 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF997 PF06196.12 EMC89275.1 - 6.9 6.8 10.8 0.25 11.4 3.9 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF997) Ferlin_C PF16165.5 EMC89276.1 - 0.053 13.5 1.3 0.079 12.9 1.3 1.2 1 0 0 1 1 1 0 Ferlin C-terminus LRR_8 PF13855.6 EMC89277.1 - 3.5e-43 145.2 63.1 4e-09 36.1 4.4 9.0 7 2 0 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 EMC89277.1 - 2.1e-35 120.2 66.8 4.9e-07 30.0 3.9 12.5 6 3 7 14 14 14 13 Leucine Rich repeats (2 copies) PP2C PF00481.21 EMC89277.1 - 7.6e-27 94.6 0.0 1.2e-26 93.9 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_1 PF00560.33 EMC89277.1 - 8.4e-07 28.7 63.1 1.2 10.0 0.1 16.6 16 2 1 17 17 17 4 Leucine Rich Repeat LRR_6 PF13516.6 EMC89277.1 - 1.5e-06 27.8 55.8 0.42 10.8 0.3 15.1 15 0 0 15 15 15 4 Leucine Rich repeat PH PF00169.29 EMC89277.1 - 0.0028 18.2 0.0 0.0063 17.0 0.0 1.6 1 0 0 1 1 1 1 PH domain AXH PF08517.12 EMC89278.1 - 3.6e-41 140.3 0.0 5.9e-41 139.7 0.0 1.3 1 0 0 1 1 1 1 Ataxin-1 and HBP1 module (AXH) zf-C2H2_4 PF13894.6 EMC89280.1 - 1.7e-07 31.5 6.8 0.0025 18.5 0.0 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.7 EMC89280.1 - 5e-07 29.9 2.9 0.95 10.0 0.2 3.5 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-Di19 PF05605.12 EMC89280.1 - 0.00018 21.7 4.5 0.0013 19.0 4.5 2.3 1 1 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 EMC89280.1 - 0.00084 19.7 12.4 0.0049 17.2 0.0 3.7 4 0 0 4 4 3 2 Zinc finger, C2H2 type zf-C2H2_9 PF16293.5 EMC89280.1 - 0.0024 17.7 1.6 2.3 8.1 0.1 3.1 2 1 0 2 2 2 2 C2H2 type zinc-finger (1 copy) zf-H2C2_2 PF13465.6 EMC89280.1 - 0.0027 18.1 0.2 2.5 8.7 0.0 3.9 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_11 PF16622.5 EMC89280.1 - 0.003 17.3 0.3 0.003 17.3 0.3 3.0 3 0 0 3 3 3 2 zinc-finger C2H2-type DZR PF12773.7 EMC89280.1 - 0.0099 15.9 2.7 0.095 12.7 2.4 2.6 2 1 1 3 3 3 1 Double zinc ribbon zf-C2H2_jaz PF12171.8 EMC89280.1 - 0.01 16.1 0.1 14 6.1 0.4 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Rad50_zn_hook PF04423.14 EMC89280.1 - 0.045 13.6 2.6 0.96 9.3 0.0 3.3 3 0 0 3 3 3 0 Rad50 zinc hook motif Prok-RING_4 PF14447.6 EMC89280.1 - 0.32 10.9 7.1 23 5.0 0.5 3.9 4 0 0 4 4 4 0 Prokaryotic RING finger family 4 zf-C2H2_6 PF13912.6 EMC89280.1 - 0.35 10.9 6.5 4.4 7.4 0.1 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger zf-FPG_IleRS PF06827.14 EMC89280.1 - 2.3 8.2 0.0 2.3 8.2 0.0 3.2 4 0 0 4 4 4 0 Zinc finger found in FPG and IleRS Peptidase_S46 PF10459.9 EMC89280.1 - 5.2 5.6 9.7 7.3 5.1 9.7 1.1 1 0 0 1 1 1 0 Peptidase S46 PhnA_Zn_Ribbon PF08274.12 EMC89280.1 - 6.5 6.8 12.9 11 6.1 0.1 3.8 3 1 0 3 3 3 0 PhnA Zinc-Ribbon Ist1 PF03398.14 EMC89281.1 - 7.9e-63 211.3 4.0 9.6e-63 211.0 4.0 1.1 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway DHO_dh PF01180.21 EMC89282.1 - 2.1e-108 362.0 0.0 2.3e-108 361.9 0.0 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.18 EMC89282.1 - 0.0028 16.8 0.4 0.0095 15.0 0.4 1.8 2 1 0 2 2 2 1 FMN-dependent dehydrogenase NMO PF03060.15 EMC89282.1 - 0.007 15.8 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 Nitronate monooxygenase Trypsin PF00089.26 EMC89283.1 - 4.5e-47 160.7 0.0 5.1e-47 160.5 0.0 1.0 1 0 0 1 1 1 1 Trypsin Golgin_A5 PF09787.9 EMC89284.1 - 0.00081 18.9 23.4 0.00085 18.9 23.4 1.0 1 0 0 1 1 1 1 Golgin subfamily A member 5 BicD PF09730.9 EMC89284.1 - 0.001 17.6 13.9 0.0011 17.5 13.9 1.0 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D EzrA PF06160.12 EMC89284.1 - 0.004 15.4 12.1 0.0035 15.6 11.4 1.3 1 1 0 1 1 1 1 Septation ring formation regulator, EzrA BRE1 PF08647.11 EMC89284.1 - 0.0078 16.3 21.1 0.017 15.2 18.3 2.2 1 1 1 2 2 2 1 BRE1 E3 ubiquitin ligase Atg14 PF10186.9 EMC89284.1 - 0.011 14.8 18.4 0.013 14.7 18.4 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Imm27 PF15590.6 EMC89284.1 - 0.075 12.8 1.7 0.95 9.3 0.1 2.2 1 1 0 2 2 2 0 Immunity protein 27 ATG16 PF08614.11 EMC89284.1 - 0.081 13.1 24.5 0.11 12.8 24.5 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) TMF_TATA_bd PF12325.8 EMC89284.1 - 0.11 12.7 20.8 0.22 11.7 20.8 1.5 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding PRKG1_interact PF15898.5 EMC89284.1 - 0.12 13.3 20.1 0.06 14.3 17.8 1.6 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain CENP-F_leu_zip PF10473.9 EMC89284.1 - 0.14 12.2 23.3 0.17 11.9 23.3 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Rsd_AlgQ PF04353.13 EMC89284.1 - 0.14 12.1 10.9 0.053 13.5 5.6 2.0 1 1 1 2 2 2 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ UPF0242 PF06785.11 EMC89284.1 - 0.15 12.2 24.4 0.16 12.1 24.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Occludin_ELL PF07303.13 EMC89284.1 - 0.29 11.9 10.9 0.34 11.7 10.4 1.4 1 1 0 1 1 1 0 Occludin homology domain BBS2_C PF14782.6 EMC89284.1 - 0.45 9.2 8.9 0.52 9.0 8.9 1.1 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal Leu_zip PF15294.6 EMC89284.1 - 0.47 9.9 16.9 0.56 9.7 16.9 1.0 1 0 0 1 1 1 0 Leucine zipper AAA_11 PF13086.6 EMC89284.1 - 0.52 10.1 10.2 0.6 9.9 10.2 1.2 1 0 0 1 1 1 0 AAA domain TPR_MLP1_2 PF07926.12 EMC89284.1 - 0.66 10.0 30.6 1.1 9.3 30.6 1.4 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein GAS PF13851.6 EMC89284.1 - 0.7 9.2 24.1 2.7 7.3 24.1 1.8 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF4200 PF13863.6 EMC89284.1 - 0.76 10.2 23.0 10 6.5 23.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) KELK PF15796.5 EMC89284.1 - 0.79 10.2 22.7 0.4 11.2 20.0 1.8 1 1 1 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase OmpH PF03938.14 EMC89284.1 - 0.88 9.9 26.2 1.2 9.5 26.2 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Spc7 PF08317.11 EMC89284.1 - 1.2 7.9 24.5 2.7 6.8 11.6 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein UvrD_C PF13361.6 EMC89284.1 - 1.7 7.9 8.0 1.8 7.9 8.0 1.0 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain TMPIT PF07851.13 EMC89284.1 - 1.9 7.6 13.2 2.2 7.4 13.2 1.1 1 0 0 1 1 1 0 TMPIT-like protein Tho2 PF11262.8 EMC89284.1 - 2.5 7.2 10.6 2.7 7.1 10.6 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 EMP24_GP25L PF01105.24 EMC89284.1 - 2.5 8.0 9.6 1.1 9.2 7.4 1.5 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD CPSF100_C PF13299.6 EMC89284.1 - 2.8 8.1 9.7 3.5 7.8 9.7 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal 5_nucleotid PF05761.14 EMC89284.1 - 3 6.7 10.4 3.2 6.5 10.4 1.1 1 0 0 1 1 1 0 5' nucleotidase family DUF3450 PF11932.8 EMC89284.1 - 3.2 7.0 23.9 4.8 6.4 23.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) DUF4407 PF14362.6 EMC89284.1 - 4.2 6.6 17.1 4.5 6.5 17.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.19 EMC89284.1 - 4.9 4.9 12.4 5.1 4.9 12.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4337 PF14235.6 EMC89284.1 - 4.9 7.2 14.8 6.2 6.9 14.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) TBCA PF02970.16 EMC89284.1 - 4.9 7.6 18.5 3.7 8.0 15.2 2.1 1 1 1 2 2 2 0 Tubulin binding cofactor A Cnn_1N PF07989.11 EMC89284.1 - 5.5 7.2 19.7 8 6.7 1.3 2.9 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 FUSC PF04632.12 EMC89284.1 - 5.8 5.3 11.9 6.4 5.2 11.9 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family BST2 PF16716.5 EMC89284.1 - 6.5 7.4 24.8 4.9 7.8 18.0 2.1 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 JIP_LZII PF16471.5 EMC89284.1 - 6.7 7.0 17.2 1.7 8.9 2.3 3.1 1 1 1 3 3 3 0 JNK-interacting protein leucine zipper II XhlA PF10779.9 EMC89284.1 - 7.3 6.9 9.0 20 5.5 7.1 2.4 1 1 1 2 2 1 0 Haemolysin XhlA ERM PF00769.19 EMC89284.1 - 7.4 6.3 30.0 8.5 6.1 30.0 1.0 1 0 0 1 1 1 0 Ezrin/radixin/moesin family ADIP PF11559.8 EMC89284.1 - 7.5 6.6 23.4 0.84 9.7 14.2 1.9 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding THOC7 PF05615.13 EMC89284.1 - 8.1 6.7 21.2 6.7 7.0 15.3 2.1 1 1 1 2 2 2 0 Tho complex subunit 7 Presenilin PF01080.17 EMC89284.1 - 8.8 5.0 8.6 9.4 4.9 8.6 1.0 1 0 0 1 1 1 0 Presenilin VIT1 PF01988.19 EMC89284.1 - 9.4 6.0 8.8 11 5.8 8.8 1.1 1 0 0 1 1 1 0 VIT family MitMem_reg PF13012.6 EMC89289.1 - 3.2e-36 124.2 0.5 5.3e-36 123.4 0.5 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EMC89289.1 - 1.2e-25 89.8 1.8 1.7e-25 89.3 0.0 2.0 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Coilin_N PF15862.5 EMC89289.1 - 0.003 17.4 8.6 0.0051 16.6 8.6 1.3 1 0 0 1 1 1 1 Coilin N-terminus Connexin PF00029.19 EMC89289.1 - 0.027 14.2 5.6 0.048 13.4 5.6 1.3 1 0 0 1 1 1 0 Connexin NOB1_Zn_bind PF08772.11 EMC89290.1 - 3.2e-33 113.7 0.1 4.8e-33 113.1 0.1 1.3 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like Zn-ribbon_8 PF09723.10 EMC89290.1 - 0.041 14.0 0.8 0.078 13.1 0.8 1.5 1 0 0 1 1 1 0 Zinc ribbon domain Peptidase_C31 PF05410.13 EMC89290.1 - 0.043 13.9 0.0 0.12 12.4 0.0 1.7 2 0 0 2 2 2 0 Porcine arterivirus-type cysteine proteinase alpha zinc_ribbon_2 PF13240.6 EMC89290.1 - 0.052 13.3 0.2 0.12 12.1 0.2 1.5 1 0 0 1 1 1 0 zinc-ribbon domain HypA PF01155.19 EMC89290.1 - 0.067 13.2 0.5 0.1 12.6 0.5 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cys_rich_KTR PF14205.6 EMC89290.1 - 0.074 12.9 0.1 0.18 11.6 0.1 1.6 1 0 0 1 1 1 0 Cysteine-rich KTR WRNPLPNID PF15017.6 EMC89290.1 - 0.16 12.9 4.8 0.27 12.1 4.8 1.4 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box RHD_dimer PF16179.5 EMC89291.1 - 3.2e-28 97.8 0.1 1.2e-27 95.9 0.1 2.1 1 0 0 1 1 1 1 Rel homology dimerisation domain RHD_DNA_bind PF00554.22 EMC89291.1 - 4.3e-21 75.6 0.2 3e-20 72.9 0.2 2.5 1 1 0 1 1 1 1 Rel homology DNA-binding domain DUF4648 PF15505.6 EMC89291.1 - 0.045 14.6 2.5 16 6.5 0.2 3.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4648) Cyt-b5 PF00173.28 EMC89292.1 - 2e-11 43.9 0.0 2.8e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain EMP24_GP25L PF01105.24 EMC89293.1 - 5.9e-27 94.8 0.0 6.7e-27 94.6 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Dor1 PF04124.12 EMC89294.1 - 4.7e-98 328.0 1.2 5.9e-98 327.7 1.2 1.0 1 0 0 1 1 1 1 Dor1-like family Exo84_C PF16528.5 EMC89294.1 - 0.00088 19.1 0.1 0.0019 18.1 0.1 1.5 1 1 0 1 1 1 1 Exocyst component 84 C-terminal Vps54_N PF10475.9 EMC89294.1 - 0.03 13.6 1.0 0.049 12.9 1.0 1.3 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex Sec5 PF15469.6 EMC89294.1 - 0.03 14.1 0.7 0.062 13.1 0.1 1.8 2 0 0 2 2 2 0 Exocyst complex component Sec5 DUF1758 PF05585.12 EMC89294.1 - 0.087 12.6 0.0 0.24 11.2 0.0 1.7 2 0 0 2 2 2 0 Putative peptidase (DUF1758) AAA_10 PF12846.7 EMC89294.1 - 0.15 10.9 0.1 0.22 10.4 0.1 1.1 1 0 0 1 1 1 0 AAA-like domain Vps4_C PF09336.10 EMC89296.1 - 6.5e-27 93.3 0.3 1.4e-26 92.2 0.3 1.6 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 EMC89296.1 - 4.9e-10 39.0 0.0 1.4e-09 37.6 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA PF00004.29 EMC89296.1 - 0.00011 22.6 0.0 0.00042 20.8 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 EMC89297.1 - 1.2e-30 106.6 0.0 2.4e-30 105.7 0.0 1.4 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 EMC89297.1 - 1.5e-06 27.7 0.0 2e-06 27.2 0.0 1.3 1 1 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 EMC89297.1 - 1.5e-06 28.5 0.2 0.00034 20.9 0.2 2.2 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EMC89297.1 - 1.6e-06 28.0 0.0 2.3e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 EMC89297.1 - 1.6e-06 28.6 0.1 0.00091 19.6 0.0 2.2 1 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EMC89297.1 - 1.7e-05 24.6 0.0 2.2e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 EMC89297.1 - 1.7e-05 24.8 0.0 2.9e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EMC89297.1 - 2e-05 24.6 0.0 6.3e-05 23.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EMC89297.1 - 6.5e-05 22.6 0.2 0.35 10.4 0.1 2.2 1 1 1 2 2 2 2 AAA domain DUF815 PF05673.13 EMC89297.1 - 9.8e-05 21.6 0.0 0.00013 21.2 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 EMC89297.1 - 0.0001 22.8 0.0 0.00022 21.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EMC89297.1 - 0.00018 21.7 0.0 0.00031 20.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EMC89297.1 - 0.00033 20.8 0.1 0.0013 18.9 0.0 1.8 1 1 1 2 2 2 1 AAA domain TniB PF05621.11 EMC89297.1 - 0.001 18.5 0.0 0.56 9.6 0.0 2.4 2 1 0 3 3 2 1 Bacterial TniB protein NACHT PF05729.12 EMC89297.1 - 0.0012 18.7 0.0 0.084 12.8 0.0 2.2 1 1 1 2 2 2 1 NACHT domain RNA_helicase PF00910.22 EMC89297.1 - 0.0029 18.0 0.0 0.0051 17.2 0.0 1.5 1 1 0 1 1 1 1 RNA helicase AAA_24 PF13479.6 EMC89297.1 - 0.0032 17.2 0.0 0.0055 16.4 0.0 1.4 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 EMC89297.1 - 0.0033 16.8 0.2 1.5 8.1 0.0 2.2 1 1 1 2 2 2 2 KaiC PhoH PF02562.16 EMC89297.1 - 0.0075 15.7 0.1 0.01 15.3 0.1 1.5 1 1 0 1 1 1 1 PhoH-like protein Mg_chelatase PF01078.21 EMC89297.1 - 0.0084 15.5 0.1 0.027 13.8 0.0 1.7 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_17 PF13207.6 EMC89297.1 - 0.0094 16.4 0.0 0.039 14.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EMC89297.1 - 0.0097 15.4 0.0 0.023 14.2 0.0 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region Sigma54_activat PF00158.26 EMC89297.1 - 0.0098 15.6 0.0 0.051 13.3 0.0 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 EMC89297.1 - 0.012 15.8 0.0 0.03 14.4 0.0 1.7 2 0 0 2 2 1 0 Sigma-54 interaction domain ATPase_2 PF01637.18 EMC89297.1 - 0.022 14.7 0.0 1.6 8.6 0.0 2.2 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_30 PF13604.6 EMC89297.1 - 0.029 14.1 0.0 0.049 13.4 0.0 1.4 1 1 0 1 1 1 0 AAA domain MCM PF00493.23 EMC89297.1 - 0.031 13.4 0.0 0.061 12.4 0.0 1.5 2 0 0 2 2 2 0 MCM P-loop domain Guanylate_kin PF00625.21 EMC89297.1 - 0.056 13.1 0.0 0.33 10.6 0.0 2.0 1 1 2 3 3 3 0 Guanylate kinase Zeta_toxin PF06414.12 EMC89297.1 - 0.058 12.7 0.1 0.58 9.4 0.0 2.2 1 1 1 2 2 2 0 Zeta toxin AFG1_ATPase PF03969.16 EMC89297.1 - 0.069 12.0 0.0 0.072 12.0 0.0 1.2 1 0 0 1 1 1 0 AFG1-like ATPase Parvo_NS1 PF01057.17 EMC89297.1 - 0.073 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_28 PF13521.6 EMC89297.1 - 0.076 13.2 0.0 0.11 12.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EMC89297.1 - 0.11 13.0 0.0 0.18 12.3 0.0 1.4 1 1 0 1 1 1 0 ABC transporter ResIII PF04851.15 EMC89297.1 - 0.11 12.5 0.0 0.15 12.1 0.0 1.4 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit KAP_NTPase PF07693.14 EMC89297.1 - 0.12 11.6 0.0 0.38 10.0 0.0 1.7 1 1 0 1 1 1 0 KAP family P-loop domain MMR_HSR1 PF01926.23 EMC89297.1 - 0.12 12.4 0.0 2.2 8.4 0.0 2.2 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_29 PF13555.6 EMC89297.1 - 0.13 12.0 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain Viral_helicase1 PF01443.18 EMC89297.1 - 0.13 12.0 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Torsin PF06309.11 EMC89297.1 - 0.17 12.0 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 Torsin EF-1_beta_acid PF10587.9 EMC89297.1 - 0.49 10.9 0.1 0.49 10.9 0.1 2.7 3 0 0 3 3 2 0 Eukaryotic elongation factor 1 beta central acidic region ANAPC4_WD40 PF12894.7 EMC89298.1 - 1e-07 32.2 0.4 0.0033 17.7 0.0 4.2 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EMC89298.1 - 3.3e-05 24.6 12.1 1.1 10.3 0.1 6.1 5 1 1 6 6 6 3 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EMC89298.1 - 0.026 13.5 0.0 0.24 10.3 0.0 2.2 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 EMC89298.1 - 0.05 11.9 0.0 0.092 11.0 0.0 1.4 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Ctf8 PF09696.10 EMC89299.1 - 3.1e-08 34.1 2.0 3.6e-07 30.6 0.2 2.5 2 1 0 2 2 2 1 Ctf8 Glyco_tranf_2_3 PF13641.6 EMC89300.1 - 3.5e-10 40.1 0.0 2.8e-05 24.1 0.0 2.2 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EMC89300.1 - 4.4e-09 36.4 0.0 0.00057 19.7 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 2 Chitin_synth_2 PF03142.15 EMC89300.1 - 0.001 17.8 0.0 0.48 9.0 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EMC89300.1 - 0.0099 15.8 0.6 0.0099 15.8 0.6 3.1 2 1 1 3 3 3 1 Glycosyl transferase family group 2 DUF1294 PF06961.13 EMC89300.1 - 0.024 14.9 1.3 0.064 13.5 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1294) CD52 PF15116.6 EMC89300.1 - 0.088 12.9 0.8 0.17 11.9 0.8 1.4 1 0 0 1 1 1 0 CAMPATH-1 antigen RTP1_C1 PF10363.9 EMC89301.1 - 8.5e-29 100.0 1.3 3.1e-28 98.2 0.0 2.6 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 EMC89301.1 - 1e-11 44.3 1.2 2.2e-11 43.2 1.2 1.6 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 2 HEAT_2 PF13646.6 EMC89301.1 - 1.4e-05 25.4 4.3 0.032 14.6 0.4 3.4 3 0 0 3 3 3 2 HEAT repeats HEAT PF02985.22 EMC89301.1 - 1.8e-05 24.6 3.7 8.2 7.0 0.2 6.3 4 1 1 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 EMC89301.1 - 0.0021 18.5 11.1 0.0024 18.3 0.1 5.1 5 1 1 6 6 6 1 HEAT-like repeat TPR_12 PF13424.6 EMC89301.1 - 0.063 13.6 0.9 12 6.3 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TetR_C_22 PF17928.1 EMC89301.1 - 0.17 12.2 3.3 6.2 7.2 0.5 3.0 2 1 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Telomere_reg-2 PF10193.9 EMC89301.1 - 2.8 8.4 6.2 12 6.4 0.0 4.0 4 0 0 4 4 4 0 Telomere length regulation protein Cadherin PF00028.17 EMC89302.1 - 1.6e-73 243.2 4.2 1.3e-21 76.8 0.2 4.1 4 0 0 4 4 4 4 Cadherin domain Cadherin_2 PF08266.12 EMC89302.1 - 0.00011 21.9 0.0 2.3 8.1 0.0 3.6 3 0 0 3 3 3 2 Cadherin-like RET_CLD1 PF17756.1 EMC89302.1 - 0.0077 16.5 0.0 4.8 7.5 0.0 3.2 2 1 0 3 3 3 2 RET Cadherin like domain 1 Transthyretin PF00576.21 EMC89303.1 - 8.8e-37 126.2 0.0 9.9e-37 126.0 0.0 1.0 1 0 0 1 1 1 1 HIUase/Transthyretin family CarboxypepD_reg PF13620.6 EMC89303.1 - 0.098 12.9 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain DUF2271 PF10029.9 EMC89303.1 - 0.13 11.9 0.1 2.3 7.9 0.0 2.1 1 1 1 2 2 2 0 Predicted periplasmic protein (DUF2271) GAS PF13851.6 EMC89304.1 - 3.9e-75 251.6 32.3 3.9e-75 251.6 32.3 2.0 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding Virulence_fact PF13769.6 EMC89304.1 - 0.09 13.0 0.1 0.09 13.0 0.1 2.6 3 0 0 3 3 3 0 Virulence factor Metal_resist PF13801.6 EMC89304.1 - 0.15 12.3 0.0 0.15 12.3 0.0 2.9 2 1 0 3 3 3 0 Heavy-metal resistance DUF948 PF06103.11 EMC89304.1 - 0.98 9.7 0.1 0.98 9.7 0.1 3.7 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) NABP PF07990.12 EMC89304.1 - 1.3 8.5 6.7 0.66 9.5 2.5 1.9 1 1 1 2 2 2 0 Nucleic acid binding protein NABP Baculo_PEP_C PF04513.12 EMC89304.1 - 1.8 8.6 15.4 2.3 8.3 3.0 3.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4852 PF16144.5 EMC89304.1 - 3.1 7.9 11.9 0.4 10.8 4.0 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4852) Cob_adeno_trans PF01923.18 EMC89304.1 - 4.9 7.3 10.0 2.5 8.2 5.9 2.4 1 1 1 2 2 2 0 Cobalamin adenosyltransferase Dysbindin PF04440.16 EMC89305.1 - 2.3e-28 99.2 0.5 2.7e-28 99.0 0.5 1.0 1 0 0 1 1 1 1 Dysbindin (Dystrobrevin binding protein 1) zf-RING_9 PF13901.6 EMC89306.1 - 4.9e-59 199.8 22.7 5.5e-59 199.6 7.4 2.4 2 1 0 2 2 2 2 Putative zinc-RING and/or ribbon C1_1 PF00130.22 EMC89306.1 - 2.9e-08 33.5 30.2 1.7e-07 31.0 8.1 4.3 3 1 1 4 4 4 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 EMC89306.1 - 0.71 10.2 30.0 0.05 13.9 2.8 4.2 4 1 0 4 4 4 0 C1 domain Tubulin PF00091.25 EMC89307.1 - 3.1e-52 177.6 0.0 5.4e-52 176.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EMC89307.1 - 1.9e-42 144.4 0.1 3.7e-42 143.5 0.1 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain 7tm_1 PF00001.21 EMC89307.1 - 1.7e-34 119.4 35.0 2.8e-33 115.4 35.0 2.2 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC89307.1 - 5.7e-11 42.7 20.2 4.3e-10 39.8 18.1 2.5 1 1 1 2 2 2 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 EMC89307.1 - 0.00011 21.7 33.8 0.00032 20.2 33.8 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC89307.1 - 0.0023 17.6 20.2 0.0023 17.6 20.2 2.7 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Tubulin_3 PF14881.6 EMC89307.1 - 0.036 13.8 0.0 0.065 12.9 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain DUF809 PF05663.11 EMC89307.1 - 0.056 13.6 1.0 0.16 12.1 1.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF809) Tubulin_2 PF13809.6 EMC89307.1 - 0.1 11.8 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Tubulin like DUF4834 PF16118.5 EMC89307.1 - 0.22 12.5 3.0 3.6 8.6 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Tcf25 PF04910.14 EMC89308.1 - 2.1e-117 392.1 7.7 2.6e-117 391.9 7.7 1.1 1 0 0 1 1 1 1 Transcriptional repressor TCF25 TPR_12 PF13424.6 EMC89308.1 - 0.049 13.9 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 EMC89308.1 - 0.17 11.7 0.0 3.1 7.8 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat SPT6_acidic PF14632.6 EMC89308.1 - 1.8 9.2 6.1 0.57 10.8 2.9 1.9 2 0 0 2 2 2 0 Acidic N-terminal SPT6 zf-C2H2 PF00096.26 EMC89309.1 - 7e-15 54.6 42.3 0.00013 22.2 2.2 6.5 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC89309.1 - 9.2e-14 51.0 40.9 0.0033 18.1 0.8 6.6 6 0 0 6 6 6 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC89309.1 - 1.9e-07 31.2 46.8 0.00031 21.0 1.1 7.2 7 1 0 7 7 7 4 Zinc-finger double domain CpXC PF14353.6 EMC89309.1 - 0.00092 19.2 13.7 0.22 11.6 0.2 4.3 2 1 2 4 4 4 2 CpXC protein zf-AD PF07776.15 EMC89309.1 - 0.0022 18.2 9.8 0.0026 17.9 0.2 3.6 3 0 0 3 3 3 1 Zinc-finger associated domain (zf-AD) Zn-ribbon_8 PF09723.10 EMC89309.1 - 0.0058 16.7 19.8 0.15 12.2 0.0 4.3 4 0 0 4 4 4 2 Zinc ribbon domain zf-C2H2_aberr PF17017.5 EMC89309.1 - 0.0091 16.2 2.9 0.0091 16.2 2.9 2.3 1 1 2 3 3 3 1 Aberrant zinc-finger zf-C2H2_6 PF13912.6 EMC89309.1 - 0.0098 15.9 0.3 0.0098 15.9 0.3 5.9 7 0 0 7 7 7 2 C2H2-type zinc finger RBR PF17208.3 EMC89309.1 - 0.12 13.1 12.5 0.49 11.2 12.5 2.0 1 0 0 1 1 1 0 RNA binding Region zf_UBZ PF18439.1 EMC89309.1 - 0.27 10.9 16.2 0.88 9.2 0.1 4.2 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger ADK_lid PF05191.14 EMC89309.1 - 3.1 7.8 15.5 0.064 13.2 1.4 3.8 4 0 0 4 4 4 0 Adenylate kinase, active site lid RbpA PF13397.6 EMC89309.1 - 3.4 8.3 6.6 9.5 6.9 0.2 3.3 3 2 1 4 4 4 0 RNA polymerase-binding protein DZR PF12773.7 EMC89309.1 - 9.3 6.4 16.1 32 4.6 10.2 3.8 2 1 0 2 2 2 0 Double zinc ribbon Pkinase PF00069.25 EMC89311.1 - 4.3e-64 216.4 0.0 5e-64 216.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC89311.1 - 2.7e-33 115.4 0.0 3.7e-33 114.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC89311.1 - 2.3e-08 33.7 0.2 3.4e-06 26.6 0.0 2.2 1 1 1 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 EMC89311.1 - 1.7e-06 27.3 0.2 4.4e-05 22.6 0.2 2.0 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EMC89311.1 - 0.0028 16.5 0.1 0.014 14.2 0.0 1.8 1 1 1 2 2 2 1 Fungal protein kinase RIO1 PF01163.22 EMC89311.1 - 0.0031 17.1 0.3 0.0058 16.3 0.2 1.3 1 1 0 1 1 1 1 RIO1 family Herpes_IE1 PF07340.11 EMC89311.1 - 0.005 15.8 0.1 0.0065 15.4 0.1 1.1 1 0 0 1 1 1 1 Cytomegalovirus IE1 protein APH PF01636.23 EMC89311.1 - 0.053 13.4 0.0 0.11 12.3 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Peptidase_M19 PF01244.21 EMC89312.1 - 9.5e-47 159.7 1.0 1e-46 159.6 1.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) RTX_C PF08339.10 EMC89312.1 - 0.0017 18.5 0.0 0.0019 18.3 0.0 1.1 1 0 0 1 1 1 1 RTX C-terminal domain Sulfotransfer_1 PF00685.27 EMC89313.1 - 5.2e-10 39.2 0.1 8.5e-10 38.5 0.1 1.2 1 1 0 1 1 1 1 Sulfotransferase domain Copine PF07002.16 EMC89314.1 - 9e-93 309.7 0.0 1e-92 309.5 0.0 1.0 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.9 EMC89314.1 - 0.00035 20.8 0.0 0.00046 20.4 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 EMC89314.1 - 0.001 19.3 0.0 0.0014 18.9 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Peptidase_M41 PF01434.18 EMC89315.1 - 1.3e-64 217.5 0.2 2.3e-64 216.8 0.2 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EMC89315.1 - 5.7e-39 133.6 0.0 1.6e-38 132.1 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMC89315.1 - 8.9e-16 57.4 0.1 3e-15 55.7 0.0 2.0 2 0 0 2 2 1 1 AAA+ lid domain FtsH_ext PF06480.15 EMC89315.1 - 1.3e-07 31.9 0.0 3e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 FtsH Extracellular AAA_17 PF13207.6 EMC89315.1 - 1.6e-06 28.6 0.0 3.5e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EMC89315.1 - 1.7e-06 28.1 0.3 3.2e-05 23.9 0.0 3.0 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EMC89315.1 - 0.00017 21.9 0.0 0.031 14.6 0.0 3.3 1 1 2 3 3 3 1 AAA domain AAA_2 PF07724.14 EMC89315.1 - 0.00017 21.7 0.0 0.0013 18.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EMC89315.1 - 0.0008 19.2 0.3 0.0033 17.2 0.0 2.0 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EMC89315.1 - 0.0014 19.1 0.2 0.0047 17.3 0.2 2.1 1 1 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.13 EMC89315.1 - 0.0037 16.5 0.0 0.0069 15.6 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 EMC89315.1 - 0.017 14.5 0.1 0.034 13.5 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF4491 PF14898.6 EMC89315.1 - 0.035 14.6 0.0 0.091 13.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4491) IstB_IS21 PF01695.17 EMC89315.1 - 0.035 13.8 0.3 0.084 12.6 0.1 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_28 PF13521.6 EMC89315.1 - 0.089 13.0 0.4 0.25 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EMC89315.1 - 0.12 12.2 0.0 0.3 11.0 0.0 1.6 1 0 0 1 1 1 0 NACHT domain PglZ PF08665.12 EMC89315.1 - 0.15 12.2 0.0 1.2 9.2 0.0 2.3 2 0 0 2 2 2 0 PglZ domain Peptidase_M50B PF13398.6 EMC89315.1 - 0.2 11.3 1.7 0.31 10.6 0.1 2.0 2 0 0 2 2 2 0 Peptidase M50B-like Ank_2 PF12796.7 EMC89316.1 - 5.3e-18 65.4 0.2 4.6e-09 36.7 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EMC89316.1 - 2.8e-17 62.3 0.2 0.00027 21.3 0.1 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EMC89316.1 - 5.2e-17 61.7 0.3 5.6e-08 32.9 0.1 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC89316.1 - 7.9e-14 51.8 0.2 5.8e-06 26.8 0.0 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC89316.1 - 3.4e-13 48.5 0.1 0.0011 19.3 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat AMP-binding PF00501.28 EMC89317.1 - 9.6e-81 271.5 0.0 1.2e-80 271.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMC89317.1 - 2.1e-16 60.7 0.0 4.9e-16 59.5 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ATR13 PF16829.5 EMC89317.1 - 0.052 13.9 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 Avirulence protein ATR13, RxLR effector RRM_1 PF00076.22 EMC89318.1 - 1.6e-16 59.8 0.0 2.4e-16 59.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMC89318.1 - 0.074 13.2 0.0 0.32 11.1 0.0 1.9 1 1 0 1 1 1 0 RNA recognition motif DUF2205 PF10224.9 EMC89318.1 - 0.13 12.3 0.3 0.2 11.7 0.3 1.4 1 0 0 1 1 1 0 Short coiled-coil protein Shugoshin_N PF07558.11 EMC89318.1 - 0.19 11.6 0.4 0.28 11.1 0.4 1.2 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region Sedlin_N PF04628.13 EMC89319.1 - 2.6e-33 114.9 0.9 2.9e-33 114.8 0.9 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 EMC89319.1 - 3.4e-10 40.0 0.2 4e-10 39.8 0.2 1.1 1 0 0 1 1 1 1 Sybindin-like family Sulfatase PF00884.23 EMC89320.1 - 9.5e-82 274.8 0.0 1.3e-81 274.4 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 EMC89320.1 - 5.7e-32 111.1 0.0 1.1e-31 110.2 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 EMC89320.1 - 5.2e-09 36.2 0.1 4.1e-08 33.2 0.1 2.0 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 EMC89320.1 - 0.018 13.7 0.0 0.022 13.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) TFIIIC_delta PF12657.7 EMC89320.1 - 0.16 11.9 0.0 0.24 11.3 0.0 1.2 1 0 0 1 1 1 0 Transcription factor IIIC subunit delta N-term Pribosyltran PF00156.27 EMC89321.1 - 9e-23 80.5 0.0 1e-22 80.3 0.0 1.0 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EMC89321.1 - 0.00013 21.5 0.0 0.00019 21.0 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 EMC89321.1 - 0.058 12.9 0.0 0.08 12.4 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase CDT1 PF08839.11 EMC89322.1 - 9.6e-50 169.3 4.3 8.8e-48 162.9 3.5 2.9 2 1 0 2 2 2 1 DNA replication factor CDT1 like CDT1_C PF16679.5 EMC89322.1 - 3.8e-37 126.6 1.0 4.3e-36 123.3 0.3 2.5 2 0 0 2 2 2 1 DNA replication factor Cdt1 C-terminal domain Piezo_RRas_bdg PF12166.8 EMC89323.1 - 3.6e-74 250.6 0.4 6.7e-74 249.7 0.1 1.5 2 0 0 2 2 2 1 Piezo non-specific cation channel, R-Ras-binding domain PBP1_TM PF14812.6 EMC89323.1 - 0.019 15.4 1.6 0.093 13.1 0.4 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-Di19 PF05605.12 EMC89324.1 - 7.9e-18 64.5 15.6 3.4e-17 62.5 3.7 2.8 2 1 1 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf_C2HC_14 PF18574.1 EMC89324.1 - 4e-14 52.1 2.5 1.4e-13 50.4 2.5 2.0 1 0 0 1 1 1 1 C2HC Zing finger domain UIM PF02809.20 EMC89324.1 - 0.00084 19.1 3.7 0.0014 18.4 3.7 1.4 1 0 0 1 1 1 1 Ubiquitin interaction motif Rubredoxin PF00301.20 EMC89324.1 - 0.0012 18.8 1.7 4.9 7.3 0.0 3.4 3 0 0 3 3 3 1 Rubredoxin zinc_ribbon_2 PF13240.6 EMC89324.1 - 0.024 14.3 0.2 0.024 14.3 0.2 4.3 4 0 0 4 4 4 0 zinc-ribbon domain zf-CHCC PF10276.9 EMC89324.1 - 0.038 14.0 0.4 1.9 8.6 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger domain zf-ribbon_3 PF13248.6 EMC89324.1 - 0.069 12.6 0.0 0.069 12.6 0.0 4.2 5 0 0 5 5 5 0 zinc-ribbon domain zf-C2H2_9 PF16293.5 EMC89324.1 - 0.12 12.2 9.8 1.3 9.0 0.3 3.4 2 1 1 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-C2H2_4 PF13894.6 EMC89324.1 - 0.29 12.1 0.6 0.29 12.1 0.6 5.2 5 1 0 5 5 4 0 C2H2-type zinc finger zinc_ribbon_10 PF10058.9 EMC89324.1 - 1.1 9.0 0.1 1.1 9.0 0.1 3.2 4 0 0 4 4 4 0 Predicted integral membrane zinc-ribbon metal-binding protein DZR PF12773.7 EMC89324.1 - 3.4 7.7 23.1 0.078 13.0 3.0 3.5 2 2 0 2 2 2 0 Double zinc ribbon zf-P11 PF03854.14 EMC89324.1 - 5 6.9 10.0 1.3 8.8 5.1 2.5 2 0 0 2 2 2 0 P-11 zinc finger Actin_micro PF17003.5 EMC89324.1 - 6.3 5.9 6.0 4.2 6.5 0.9 2.6 2 1 0 2 2 2 0 Putative actin-like family Rad50_zn_hook PF04423.14 EMC89324.1 - 7.1 6.6 13.2 0.57 10.1 0.2 3.3 2 1 1 3 3 3 0 Rad50 zinc hook motif zf-H2C2_2 PF13465.6 EMC89324.1 - 7.6 7.1 14.8 1.4 9.5 0.7 4.2 4 0 0 4 4 4 0 Zinc-finger double domain zf-C4pol PF14260.6 EMC89324.1 - 8.4 6.9 15.1 1.1 9.7 6.1 2.8 2 2 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta MDD_C PF18376.1 EMC89325.1 - 4.2e-65 219.0 0.0 6.4e-65 218.4 0.0 1.3 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 EMC89325.1 - 0.0019 18.4 0.4 0.0051 17.0 0.3 1.7 2 0 0 2 2 2 1 GHMP kinases N terminal domain Cytochrom_B558a PF05038.13 EMC89326.1 - 4.5e-53 179.6 8.0 3.9e-47 160.2 1.7 2.0 2 0 0 2 2 2 2 Cytochrome Cytochrome b558 alpha-subunit IL17 PF06083.11 EMC89327.1 - 8.7e-30 103.0 0.7 1.3e-29 102.5 0.7 1.3 1 0 0 1 1 1 1 Interleukin-17 CIDE-N PF02017.15 EMC89328.1 - 5.5e-14 51.9 0.1 8.7e-14 51.3 0.1 1.3 1 0 0 1 1 1 1 CIDE-N domain GlyL_C PF12524.8 EMC89328.1 - 0.27 11.4 1.0 2.4 8.4 0.4 2.7 2 1 0 2 2 2 0 dsDNA virus glycoprotein L C terminal zf-C2H2 PF00096.26 EMC89329.1 - 1.4e-09 37.9 19.8 0.00047 20.5 1.1 4.4 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC89329.1 - 8.8e-07 29.3 21.4 0.04 14.7 0.1 4.5 4 0 0 4 4 4 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC89329.1 - 2.1e-05 24.7 0.0 2.1e-05 24.7 0.0 4.7 4 1 0 4 4 4 1 Zinc-finger double domain zf-met PF12874.7 EMC89329.1 - 2.1e-05 24.7 10.5 0.046 14.1 1.0 3.6 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 EMC89329.1 - 7.8e-05 22.9 3.9 0.11 12.8 3.2 2.6 2 0 0 2 2 2 2 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 EMC89329.1 - 0.00012 22.3 5.4 0.062 13.6 0.0 3.2 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding GAGA PF09237.11 EMC89329.1 - 0.12 12.2 2.5 0.82 9.5 1.0 2.4 2 0 0 2 2 2 0 GAGA factor zf_Hakai PF18408.1 EMC89329.1 - 0.45 10.3 0.1 0.45 10.3 0.1 2.8 3 0 0 3 3 3 0 C2H2 Hakai zinc finger domain Vps36-NZF-N PF16988.5 EMC89329.1 - 0.7 9.3 6.7 0.81 9.1 0.6 2.6 3 0 0 3 3 3 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain PriA_CRR PF18319.1 EMC89329.1 - 1.6 8.8 12.7 0.19 11.8 1.5 4.0 5 0 0 5 5 5 0 PriA DNA helicase Cys-rich region (CRR) domain zf-MYST PF17772.1 EMC89329.1 - 2.1 8.0 6.3 5.3 6.7 1.0 3.2 2 2 0 2 2 2 0 MYST family zinc finger domain zf-H2C2_5 PF13909.6 EMC89329.1 - 3.8 7.3 11.6 0.49 10.2 0.2 3.5 4 0 0 4 4 4 0 C2H2-type zinc-finger domain TF_Zn_Ribbon PF08271.12 EMC89329.1 - 4.6 6.8 8.1 3.1 7.4 2.1 3.3 3 1 0 3 3 3 0 TFIIB zinc-binding zf-C2H2 PF00096.26 EMC89330.1 - 5.8e-08 32.8 22.0 0.0061 16.9 3.1 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC89330.1 - 2.8e-06 27.7 24.4 0.0045 17.7 1.4 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EMC89330.1 - 0.0021 18.4 9.9 0.0021 18.4 9.9 2.4 1 1 1 2 2 2 1 C2H2 type zinc-finger (2 copies) Zn_ribbon_SprT PF17283.2 EMC89330.1 - 0.69 9.9 6.2 0.25 11.3 2.5 2.3 2 0 0 2 2 2 0 SprT-like zinc ribbon domain zf-MYST PF17772.1 EMC89330.1 - 1.1 8.9 17.0 0.63 9.7 1.1 3.7 2 2 2 4 4 4 0 MYST family zinc finger domain zf-met PF12874.7 EMC89330.1 - 1.2 9.6 12.7 0.076 13.4 1.8 3.7 4 0 0 4 4 4 0 Zinc-finger of C2H2 type DUF629 PF04780.12 EMC89330.1 - 2.1 6.8 8.1 2.7 6.4 0.7 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF629) Actin_micro PF17003.5 EMC89330.1 - 3 6.9 11.6 1.8 7.7 3.5 2.2 1 1 1 2 2 2 0 Putative actin-like family zf-C2H2_jaz PF12171.8 EMC89330.1 - 7.6 7.0 23.1 0.096 13.0 3.1 4.1 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding BEN PF10523.9 EMC89331.1 - 5e-07 29.9 0.0 1.2e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 BEN domain Carb_anhydrase PF00194.21 EMC89332.1 - 7.9e-86 287.7 0.0 9.9e-86 287.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Tudor_3 PF18115.1 EMC89332.1 - 0.014 15.2 0.0 0.24 11.3 0.0 2.6 3 0 0 3 3 3 0 DNA repair protein Crb2 Tudor domain AA_permease_2 PF13520.6 EMC89333.1 - 2.9e-63 214.2 42.5 3.5e-63 213.9 42.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMC89333.1 - 1.1e-25 90.3 37.8 1.5e-25 89.7 37.8 1.1 1 0 0 1 1 1 1 Amino acid permease SirB PF04247.12 EMC89333.1 - 0.74 9.9 9.6 0.23 11.5 0.2 2.9 2 1 0 2 2 2 0 Invasion gene expression up-regulator, SirB DUF4448 PF14610.6 EMC89333.1 - 0.85 9.4 2.9 13 5.5 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) Kelch_4 PF13418.6 EMC89334.1 - 4.6e-39 132.2 0.4 4.8e-11 42.5 0.0 6.6 6 1 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 EMC89334.1 - 4e-33 113.1 4.0 9.1e-08 32.2 0.1 7.5 7 1 0 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC89334.1 - 1.9e-27 94.8 6.7 1.2e-07 31.6 0.2 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EMC89334.1 - 6.7e-27 92.9 6.6 7.9e-07 29.1 0.0 6.8 5 2 1 6 6 6 5 Kelch motif Kelch_2 PF07646.15 EMC89334.1 - 3.6e-18 64.7 16.3 5.2e-05 23.1 0.0 8.0 6 3 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 EMC89334.1 - 1.1e-15 56.9 13.3 1.3e-06 27.9 0.0 7.7 7 2 0 7 7 7 4 Kelch motif DUF4110 PF13422.6 EMC89334.1 - 0.0061 16.6 0.1 0.0061 16.6 0.1 3.0 2 1 1 3 3 3 1 Domain of unknown function (DUF4110) Atg8 PF02991.16 EMC89335.1 - 1e-43 147.7 0.2 1.2e-43 147.6 0.2 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EMC89335.1 - 1.8e-06 28.2 0.0 2.3e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Rad60-SLD PF11976.8 EMC89335.1 - 0.077 12.8 0.1 0.63 9.9 0.0 2.1 1 1 1 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Cytochrom_B559a PF00284.20 EMC89335.1 - 0.16 11.7 0.0 0.37 10.6 0.0 1.5 1 0 0 1 1 1 0 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit SBF2 PF12335.8 EMC89336.1 - 0.00015 21.5 3.2 0.00018 21.2 0.3 2.3 2 1 0 2 2 2 1 Myotubularin protein DUF1754 PF08555.10 EMC89336.1 - 0.61 10.9 10.9 0.042 14.6 3.2 2.3 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) COX4 PF02936.14 EMC89337.1 - 2.8e-56 189.4 0.4 3.2e-56 189.2 0.4 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DSPc PF00782.20 EMC89338.1 - 2.1e-28 98.8 0.0 2.6e-28 98.5 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMC89338.1 - 7.9e-05 22.3 0.0 8.9e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EMC89338.1 - 0.0064 16.6 0.0 0.01 15.9 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate Init_tRNA_PT PF04179.12 EMC89338.1 - 0.099 12.9 0.1 0.13 12.6 0.1 1.3 1 0 0 1 1 1 0 Rit1 DUSP-like domain IRF-3 PF10401.9 EMC89339.1 - 1.3e-64 217.3 0.1 1.8e-64 216.8 0.1 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IRF PF00605.17 EMC89339.1 - 1.4e-42 144.2 0.6 2.5e-42 143.4 0.6 1.4 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor MH2 PF03166.14 EMC89339.1 - 0.0043 17.3 0.0 0.0068 16.7 0.0 1.3 1 0 0 1 1 1 1 MH2 domain Forkhead PF00250.18 EMC89340.1 - 2.2e-23 82.3 0.0 8.7e-23 80.4 0.0 2.0 2 0 0 2 2 2 1 Forkhead domain Forkhead PF00250.18 EMC89341.1 - 1.7e-40 137.2 0.1 2.9e-40 136.4 0.1 1.4 1 0 0 1 1 1 1 Forkhead domain Forkhead PF00250.18 EMC89342.1 - 1.4e-40 137.4 0.0 1.5e-40 137.3 0.0 1.0 1 0 0 1 1 1 1 Forkhead domain DHHC PF01529.20 EMC89344.1 - 4.7e-36 123.9 13.5 4.7e-36 123.9 13.5 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase TRIQK PF15168.6 EMC89344.1 - 0.25 11.3 2.6 4.6 7.2 0.0 2.5 2 0 0 2 2 2 0 Triple QxxK/R motif-containing protein family DUF3615 PF12274.8 EMC89344.1 - 0.34 11.4 4.1 0.69 10.5 4.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3615) DUF4191 PF13829.6 EMC89344.1 - 3.6 6.9 3.8 6.1 6.1 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) Hormone_recep PF00104.30 EMC89345.1 - 1.3e-39 135.9 0.1 2.5e-39 135.0 0.0 1.5 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 EMC89345.1 - 6.2e-30 103.5 18.0 1e-29 102.8 18.0 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) LCCL PF03815.19 EMC89346.1 - 7.9e-50 166.9 12.2 1.2e-26 92.6 0.3 3.1 3 0 0 3 3 3 2 LCCL domain CAP PF00188.26 EMC89346.1 - 7.2e-22 78.6 5.8 1.5e-21 77.6 5.8 1.5 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Rxt3 PF08642.10 EMC89346.1 - 2e-05 25.3 0.0 0.0058 17.4 0.0 2.6 2 0 0 2 2 2 2 Histone deacetylation protein Rxt3 DUF5607 PF18355.1 EMC89346.1 - 0.0066 16.9 0.1 0.018 15.4 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5607) UCH PF00443.29 EMC89347.1 - 4.8e-45 154.1 0.0 6.3e-45 153.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMC89347.1 - 3.7e-10 39.9 0.2 9.8e-08 31.9 0.2 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PAM2 PF07145.15 EMC89347.1 - 3.6e-05 23.2 0.0 9.4e-05 21.8 0.0 1.8 1 0 0 1 1 1 1 Ataxin-2 C-terminal region Kelch_1 PF01344.25 EMC89348.1 - 2.1e-42 142.4 11.6 1.1e-09 37.7 0.1 6.5 6 1 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 EMC89348.1 - 2.5e-32 110.1 3.3 6.7e-05 23.0 0.1 6.6 4 2 2 6 6 6 6 Kelch motif BTB PF00651.31 EMC89348.1 - 6.7e-28 97.1 0.7 3.7e-27 94.8 0.0 2.5 2 1 1 3 3 3 1 BTB/POZ domain Kelch_2 PF07646.15 EMC89348.1 - 5.5e-22 76.8 6.0 9.3e-05 22.3 0.3 6.6 6 0 0 6 6 6 4 Kelch motif BACK PF07707.15 EMC89348.1 - 1.9e-21 76.0 0.3 3.7e-21 75.2 0.3 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_4 PF13418.6 EMC89348.1 - 5.3e-20 71.2 2.4 0.005 16.8 0.1 5.6 5 1 0 5 5 5 5 Galactose oxidase, central domain Kelch_3 PF13415.6 EMC89348.1 - 1e-14 54.3 1.0 0.32 11.3 0.2 6.5 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC89348.1 - 1.3e-14 53.7 2.3 1.3e-05 25.0 0.1 5.6 5 0 0 5 5 5 3 Kelch motif Cofilin_ADF PF00241.20 EMC89349.1 - 1.5e-20 73.2 0.1 1.8e-20 73.0 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein TLD PF07534.16 EMC89351.1 - 4.5e-39 133.8 0.3 7e-39 133.2 0.3 1.3 1 0 0 1 1 1 1 TLD E1-E2_ATPase PF00122.20 EMC89352.1 - 1.1e-50 171.7 0.1 1.1e-50 171.7 0.1 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EMC89352.1 - 4.4e-44 150.4 6.6 4.4e-44 150.4 6.6 2.6 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase_N PF00690.26 EMC89352.1 - 3.8e-16 58.5 0.1 8.1e-16 57.5 0.1 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 EMC89352.1 - 4e-16 59.9 2.9 2.6e-15 57.3 2.9 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EMC89352.1 - 1.9e-15 56.7 0.2 1.1e-14 54.3 0.1 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EMC89352.1 - 0.00064 19.5 2.0 0.00077 19.3 0.7 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3784 PF12650.7 EMC89352.1 - 0.32 11.2 6.1 9.4 6.5 0.3 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3784) WAP PF00095.21 EMC89353.1 - 2.1e-06 28.0 15.1 2.1e-06 28.0 15.1 2.2 2 0 0 2 2 2 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' BTB_2 PF02214.22 EMC89354.1 - 1.7e-25 89.2 0.0 3.8e-25 88.0 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans PF00520.31 EMC89355.1 - 3.5e-05 23.2 0.2 3.8e-05 23.0 0.2 1.0 1 0 0 1 1 1 1 Ion transport protein HSBP1 PF06825.12 EMC89356.1 - 4e-26 90.6 6.8 1.1e-25 89.3 6.8 1.6 1 1 0 1 1 1 1 Heat shock factor binding protein 1 EURL PF06937.11 EMC89356.1 - 0.0021 17.5 0.2 0.0024 17.4 0.2 1.0 1 0 0 1 1 1 1 EURL protein BST2 PF16716.5 EMC89356.1 - 0.011 16.3 0.7 0.017 15.7 0.7 1.3 1 1 0 1 1 1 0 Bone marrow stromal antigen 2 BLOC1_2 PF10046.9 EMC89356.1 - 0.015 15.6 0.4 0.022 15.1 0.4 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 GOLGA2L5 PF15070.6 EMC89356.1 - 0.016 13.9 0.1 0.017 13.8 0.1 1.0 1 0 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 Matrilin_ccoil PF10393.9 EMC89356.1 - 0.032 14.1 0.1 0.17 11.7 0.1 2.1 1 1 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin YscO PF07321.12 EMC89356.1 - 0.051 13.5 0.1 0.055 13.4 0.1 1.1 1 0 0 1 1 1 0 Type III secretion protein YscO Cadherin PF00028.17 EMC89357.1 - 2e-70 233.3 3.3 1.1e-19 70.6 0.0 4.2 4 0 0 4 4 4 4 Cadherin domain Cadherin_3 PF16184.5 EMC89357.1 - 2.6e-11 43.5 4.4 0.00097 19.1 0.2 4.9 5 0 0 5 5 5 4 Cadherin-like Cadherin_4 PF17803.1 EMC89357.1 - 4.8e-05 23.9 16.8 0.00011 22.8 2.1 3.9 4 0 0 4 4 4 2 Bacterial cadherin-like domain Big_9 PF17963.1 EMC89357.1 - 0.00012 22.8 2.5 0.00012 22.8 2.5 3.3 3 0 0 3 3 3 1 Bacterial Ig domain MPP6 PF10175.9 EMC89358.1 - 3.5e-35 121.4 5.5 3.5e-35 121.4 5.5 1.7 1 1 1 2 2 2 1 M-phase phosphoprotein 6 DUF5085 PF16895.5 EMC89358.1 - 0.02 15.3 1.4 0.026 14.8 0.5 1.7 2 1 0 2 2 2 0 Domain of unknown function (DUF5085) DUF3864 PF12980.7 EMC89358.1 - 0.033 14.5 0.4 0.075 13.4 0.1 1.8 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3864) Acetyltransf_2 PF00797.17 EMC89359.1 - 3.4e-94 315.1 0.6 3.9e-94 314.9 0.6 1.0 1 0 0 1 1 1 1 N-acetyltransferase DUF553 PF04473.12 EMC89359.1 - 0.18 11.3 1.2 0.92 9.0 0.0 2.4 3 1 0 3 3 3 0 Transglutaminase-like domain Acetyltransf_2 PF00797.17 EMC89360.1 - 6.3e-88 294.6 0.0 7.2e-88 294.4 0.0 1.0 1 0 0 1 1 1 1 N-acetyltransferase Acetyltransf_2 PF00797.17 EMC89361.1 - 7.4e-90 300.9 0.1 8.4e-90 300.7 0.1 1.0 1 0 0 1 1 1 1 N-acetyltransferase adh_short PF00106.25 EMC89362.1 - 3.4e-44 150.6 0.5 5e-44 150.1 0.0 1.5 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC89362.1 - 6.3e-26 91.4 0.0 9.2e-26 90.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC89362.1 - 5e-06 26.5 0.4 2.4e-05 24.3 0.4 1.9 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.10 EMC89362.1 - 0.00034 20.1 0.0 0.00089 18.7 0.0 1.6 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) 3Beta_HSD PF01073.19 EMC89363.1 - 7.6e-71 238.4 0.0 9.6e-71 238.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EMC89363.1 - 3e-25 89.1 0.0 3.9e-25 88.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EMC89363.1 - 3e-10 39.7 0.0 4e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EMC89363.1 - 7.4e-09 35.4 0.0 5.4e-07 29.3 0.0 2.4 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EMC89363.1 - 1.5e-06 27.6 0.0 3.3e-06 26.5 0.0 1.5 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 EMC89363.1 - 2.3e-06 27.0 0.3 8.7e-06 25.1 0.3 1.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EMC89363.1 - 0.00064 19.7 0.0 0.00088 19.2 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding PI-PLC-X PF00388.19 EMC89364.1 - 7.2e-67 223.5 0.1 1.7e-66 222.3 0.1 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain SH2 PF00017.24 EMC89364.1 - 6.4e-47 157.6 0.4 1.4e-24 86.0 0.0 2.9 2 0 0 2 2 2 2 SH2 domain PI-PLC-Y PF00387.19 EMC89364.1 - 1.1e-37 128.9 0.0 3.9e-37 127.1 0.0 2.1 2 0 0 2 2 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 EMC89364.1 - 1.3e-14 54.3 0.0 4.6e-14 52.6 0.0 2.0 1 0 0 1 1 1 1 C2 domain SH3_1 PF00018.28 EMC89364.1 - 4.3e-13 48.7 0.1 1.3e-12 47.1 0.1 1.9 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC89364.1 - 4.7e-11 42.4 0.1 2.1e-10 40.3 0.1 2.2 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.29 EMC89364.1 - 3.6e-08 33.9 1.6 0.15 12.6 0.0 4.4 3 0 0 3 3 3 3 PH domain SH3_2 PF07653.17 EMC89364.1 - 1.3e-05 24.7 0.0 3.7e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain PH_12 PF16457.5 EMC89364.1 - 0.00018 22.0 2.1 0.00083 19.9 0.0 3.1 3 0 0 3 3 3 1 Pleckstrin homology domain PH_14 PF17787.1 EMC89364.1 - 0.009 15.9 0.1 0.027 14.3 0.1 1.9 1 0 0 1 1 1 1 PH domain GDPD PF03009.17 EMC89364.1 - 0.073 12.8 0.0 0.21 11.3 0.0 1.8 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family Kelch_1 PF01344.25 EMC89365.1 - 3e-39 132.3 3.1 1.4e-09 37.4 0.0 6.3 6 1 0 6 6 6 4 Kelch motif BACK PF07707.15 EMC89365.1 - 2.4e-29 101.5 1.7 4e-29 100.8 0.6 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_6 PF13964.6 EMC89365.1 - 2.8e-21 75.0 9.6 3.6e-08 33.4 0.0 6.1 3 2 3 6 6 6 3 Kelch motif Kelch_2 PF07646.15 EMC89365.1 - 6.1e-14 51.4 0.8 0.026 14.5 0.0 5.8 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 EMC89365.1 - 5.1e-13 48.8 4.9 2.3e-05 24.3 0.0 5.3 5 1 0 5 5 5 2 Galactose oxidase, central domain BTB PF00651.31 EMC89365.1 - 1.9e-10 41.0 0.0 4.4e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.6 EMC89365.1 - 1e-08 35.2 0.4 0.042 14.1 0.0 5.6 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC89365.1 - 2.6e-07 30.5 4.9 0.024 14.6 0.0 4.8 5 0 0 5 5 5 1 Kelch motif DUF1668 PF07893.13 EMC89365.1 - 0.0062 15.9 0.0 0.61 9.4 0.0 2.5 1 1 0 2 2 2 1 Protein of unknown function (DUF1668) BTB_3 PF16017.5 EMC89365.1 - 0.013 15.5 0.0 0.03 14.4 0.0 1.6 1 0 0 1 1 1 0 BTB/POZ domain RPE65 PF03055.15 EMC89366.1 - 7.1e-128 427.7 1.1 8e-128 427.5 1.1 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein DUF4096 PF13340.6 EMC89366.1 - 0.12 12.6 0.3 0.24 11.6 0.3 1.4 1 0 0 1 1 1 0 Putative transposase of IS4/5 family (DUF4096) GCV_H PF01597.19 EMC89367.1 - 7.1e-48 161.5 0.1 7.9e-48 161.4 0.1 1.0 1 0 0 1 1 1 1 Glycine cleavage H-protein zf-C2H2_4 PF13894.6 EMC89368.1 - 0.085 13.7 12.8 2.4 9.2 0.5 4.2 2 1 1 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC89368.1 - 1.3 9.7 19.0 1.1 9.8 0.2 4.6 3 1 1 4 4 4 0 Zinc finger, C2H2 type CENP-N PF05238.13 EMC89369.1 - 2.6e-69 234.6 4.2 9.4e-68 229.4 4.2 2.0 1 1 0 1 1 1 1 Kinetochore protein CHL4 like Nudix_hydro PF18290.1 EMC89369.1 - 0.069 13.2 0.0 0.18 11.8 0.0 1.7 1 0 0 1 1 1 0 Nudix hydrolase domain Cmc1 PF08583.10 EMC89370.1 - 2.9e-16 59.2 5.1 3.3e-16 59.0 5.1 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like DUF755 PF05501.11 EMC89370.1 - 0.037 14.3 2.2 0.044 14.0 2.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Robl_LC7 PF03259.17 EMC89372.1 - 4.4e-26 90.5 0.0 4.8e-26 90.4 0.0 1.0 1 0 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.5 EMC89372.1 - 0.016 15.1 0.0 0.019 14.9 0.0 1.1 1 0 0 1 1 1 0 Ragulator complex protein LAMTOR5 Iwr1 PF08574.10 EMC89373.1 - 5.3e-07 30.5 19.8 5.3e-07 30.5 19.8 3.3 3 2 1 4 4 4 1 Transcription factor Iwr1 AA_permease_2 PF13520.6 EMC89374.1 - 9.2e-64 215.8 39.1 1.1e-63 215.5 39.1 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMC89374.1 - 1.9e-26 92.7 31.5 1.9e-26 92.7 31.5 1.4 1 1 0 1 1 1 1 Amino acid permease Pkinase_Tyr PF07714.17 EMC89375.1 - 7.5e-26 91.0 0.0 9.4e-26 90.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC89375.1 - 4.5e-25 88.5 0.0 5.2e-25 88.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EMC89375.1 - 0.025 13.9 0.0 0.034 13.5 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMC89375.1 - 0.086 12.7 0.3 0.16 11.9 0.1 1.5 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pyr_redox_3 PF13738.6 EMC89376.1 - 1.2e-11 44.4 0.0 4.1e-08 32.8 0.0 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMC89376.1 - 9e-09 35.0 0.0 2.1e-07 30.5 0.0 2.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMC89376.1 - 0.013 14.7 0.0 0.029 13.5 0.0 1.4 1 1 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Peptidase_S8 PF00082.22 EMC89377.1 - 8.3e-40 136.9 0.1 1.3e-39 136.2 0.1 1.3 1 0 0 1 1 1 1 Subtilase family ABC_transp_aux PF09822.9 EMC89377.1 - 0.057 12.9 0.0 0.098 12.1 0.0 1.3 1 0 0 1 1 1 0 ABC-type uncharacterized transport system adh_short PF00106.25 EMC89378.1 - 1.8e-41 141.8 0.0 2.2e-41 141.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC89378.1 - 2.6e-26 92.6 0.0 3.6e-26 92.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC89378.1 - 3.4e-06 27.1 0.0 5.9e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EMC89378.1 - 0.00029 20.1 0.1 0.0013 17.9 0.1 2.0 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 EMC89378.1 - 0.0012 19.1 0.0 0.0041 17.4 0.0 1.8 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EMC89378.1 - 0.0083 15.6 0.3 0.048 13.1 0.3 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EMC89378.1 - 0.021 14.7 0.0 0.03 14.2 0.0 1.2 1 0 0 1 1 1 0 NAD(P)H-binding ApbA PF02558.16 EMC89378.1 - 0.056 13.1 0.0 0.093 12.4 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Adenylsucc_synt PF00709.21 EMC89378.1 - 0.1 11.5 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Adenylosuccinate synthetase LRR_9 PF14580.6 EMC89379.1 - 3.4e-18 65.8 6.4 5.2e-14 52.1 2.5 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 EMC89379.1 - 1.4e-16 60.3 46.6 1.5e-05 25.3 1.3 4.5 1 1 6 7 7 7 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMC89379.1 - 2.5e-10 40.0 24.2 2.1e-06 27.4 2.2 4.2 2 1 3 5 5 5 4 Leucine rich repeat LRR_6 PF13516.6 EMC89379.1 - 0.00022 21.0 8.5 0.4 10.8 0.1 4.8 5 0 0 5 5 5 2 Leucine Rich repeat Arm_3 PF16186.5 EMC89379.1 - 0.51 9.9 3.7 30 4.3 0.0 3.7 4 1 1 5 5 5 0 Atypical Arm repeat LRR_1 PF00560.33 EMC89379.1 - 1.2 9.9 14.1 25 6.0 0.0 5.5 5 1 0 5 5 5 0 Leucine Rich Repeat HSF_DNA-bind PF00447.17 EMC89380.1 - 1.2e-31 109.1 0.5 1.2e-31 109.1 0.5 1.8 2 0 0 2 2 2 1 HSF-type DNA-binding Vert_HS_TF PF06546.11 EMC89380.1 - 4.2e-19 69.3 0.1 1.3e-18 67.6 0.0 1.7 2 0 0 2 2 2 1 Vertebrate heat shock transcription factor YscO PF07321.12 EMC89380.1 - 0.004 17.1 5.1 0.0061 16.5 5.1 1.2 1 0 0 1 1 1 1 Type III secretion protein YscO MobL PF18555.1 EMC89380.1 - 0.0084 15.4 0.7 0.012 14.9 0.7 1.1 1 0 0 1 1 1 1 MobL relaxases Ets PF00178.22 EMC89380.1 - 0.13 12.7 1.1 0.81 10.2 0.0 2.6 3 0 0 3 3 3 0 Ets-domain ZapB PF06005.12 EMC89380.1 - 0.52 10.8 9.5 0.62 10.6 8.5 1.6 1 1 0 1 1 1 0 Cell division protein ZapB F-box-like PF12937.7 EMC89381.1 - 4.5e-14 52.1 1.1 5.3e-14 51.8 1.1 1.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMC89381.1 - 1.6e-08 34.2 0.1 1.8e-08 34.0 0.1 1.1 1 0 0 1 1 1 1 F-box domain F-box_5 PF18511.1 EMC89381.1 - 3.6e-06 26.5 0.1 4.8e-06 26.0 0.1 1.3 1 0 0 1 1 1 1 F-box PRANC PF09372.10 EMC89381.1 - 0.014 15.7 0.5 0.021 15.2 0.5 1.3 1 1 0 1 1 1 0 PRANC domain Suv3_C_1 PF18147.1 EMC89381.1 - 0.14 12.1 0.4 1.2 9.1 0.1 2.0 1 1 1 2 2 2 0 Suv3 C-terminal domain 1 TRADD_N PF09034.10 EMC89382.1 - 2.9e-48 162.6 3.6 4.7e-48 161.9 3.6 1.3 1 0 0 1 1 1 1 TRADD, N-terminal domain Death PF00531.22 EMC89382.1 - 2.2e-08 34.2 0.8 6.7e-08 32.6 0.2 2.0 2 0 0 2 2 2 1 Death domain Galactosyl_T PF01762.21 EMC89383.1 - 7.1e-46 156.5 0.0 8.8e-46 156.2 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 EMC89383.1 - 1.1e-08 34.9 0.0 1.9e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Fringe-like UPF0183 PF03676.14 EMC89384.1 - 9.8e-158 525.5 0.9 1.1e-157 525.4 0.9 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0183) CBF_beta PF02312.17 EMC89385.1 - 1.6e-48 164.5 0.1 1.8e-48 164.3 0.1 1.0 1 0 0 1 1 1 1 Core binding factor beta subunit DUF1674 PF07896.12 EMC89385.1 - 2.8 8.5 6.5 21 5.7 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1674) G-alpha PF00503.20 EMC89386.1 - 1.3e-107 360.0 2.8 1.5e-107 359.8 2.8 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EMC89386.1 - 3.7e-13 49.3 0.0 8.5e-13 48.1 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EMC89386.1 - 0.00056 19.3 0.5 0.001 18.5 0.3 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region HMG_CoA_synt_C PF08540.10 EMC89386.1 - 0.052 13.2 0.2 0.52 9.9 0.0 2.2 2 1 0 2 2 2 0 Hydroxymethylglutaryl-coenzyme A synthase C terminal G2BR PF18442.1 EMC89387.1 - 1.1e-17 63.3 7.9 3.4e-17 61.8 7.9 1.9 1 0 0 1 1 1 1 E3 gp78 Ube2g2-binding region (G2BR) zf-RING_2 PF13639.6 EMC89387.1 - 3e-12 46.7 7.1 3e-12 46.7 7.1 1.9 2 0 0 2 2 1 1 Ring finger domain CUE PF02845.16 EMC89387.1 - 1.4e-10 40.7 0.1 2.9e-10 39.7 0.1 1.6 1 0 0 1 1 1 1 CUE domain zf-C3HC4_2 PF13923.6 EMC89387.1 - 3.1e-10 39.7 6.3 9.2e-10 38.2 6.3 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC89387.1 - 4.5e-08 32.8 5.2 8.8e-08 31.9 5.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMC89387.1 - 9.7e-08 31.8 3.2 2.5e-07 30.5 3.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC89387.1 - 1.8e-07 31.1 2.4 4.1e-07 29.9 2.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 EMC89387.1 - 6.2e-07 29.0 1.5 6.2e-07 29.0 1.5 2.5 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.7 EMC89387.1 - 6.3e-07 29.6 9.6 6.5e-06 26.4 8.7 2.8 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EMC89387.1 - 1.6e-05 24.8 3.6 3.3e-05 23.8 3.6 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC89387.1 - 1.7e-05 24.6 5.4 3.7e-05 23.5 5.4 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EMC89387.1 - 2.8e-05 24.1 0.6 8.8e-05 22.5 0.6 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EMC89387.1 - 2.9e-05 23.6 4.4 7.3e-05 22.3 4.4 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 EMC89387.1 - 0.0028 17.8 4.6 0.0053 16.9 4.6 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING RINGv PF12906.7 EMC89387.1 - 0.27 11.4 7.6 0.6 10.3 7.6 1.6 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 EMC89387.1 - 0.46 10.7 5.6 1.4 9.1 5.6 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain NUDIX_2 PF13869.6 EMC89388.1 - 7e-73 244.2 0.0 8.1e-73 244.0 0.0 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase Metallothio PF00131.20 EMC89389.1 - 7e-21 74.1 63.6 7.6e-21 74.0 63.6 1.0 1 0 0 1 1 1 1 Metallothionein Metallothio PF00131.20 EMC89390.1 - 3.2e-17 62.4 63.3 3.4e-17 62.3 63.3 1.0 1 0 0 1 1 1 1 Metallothionein Nic96 PF04097.14 EMC89391.1 - 2e-195 650.9 0.8 3e-195 650.3 0.8 1.3 1 0 0 1 1 1 1 Nup93/Nic96 Nup84_Nup100 PF04121.13 EMC89391.1 - 0.00096 17.4 0.4 0.0019 16.4 0.4 1.4 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 Clathrin PF00637.20 EMC89391.1 - 0.065 13.1 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 Region in Clathrin and VPS BCNT PF07572.12 EMC89392.1 - 5.2e-31 106.5 2.4 1.5e-30 105.1 0.4 2.0 2 0 0 2 2 2 1 Bucentaur or craniofacial development CAS_C PF12026.8 EMC89393.1 - 3.3e-81 272.4 0.8 5.2e-81 271.7 0.8 1.3 1 0 0 1 1 1 1 Crk-Associated Substrate C-terminal domain Serine_rich PF08824.10 EMC89393.1 - 8.5e-58 194.8 1.0 1.7e-57 193.8 0.0 2.0 3 0 0 3 3 3 1 Serine rich protein interaction domain SH3_1 PF00018.28 EMC89393.1 - 4.2e-14 51.9 0.2 1e-13 50.6 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EMC89393.1 - 3.5e-13 49.2 0.0 1.4e-12 47.2 0.0 2.1 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC89393.1 - 6.1e-10 38.6 0.0 1.6e-09 37.3 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Neurokinin_B PF03823.14 EMC89393.1 - 5.8 7.0 5.6 27 4.9 0.2 4.2 3 1 2 5 5 5 0 Neurokinin B Trypsin PF00089.26 EMC89394.1 - 1.7e-72 243.8 0.9 1.9e-72 243.6 0.9 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EMC89394.1 - 4.5e-08 34.1 0.2 6.3e-08 33.6 0.2 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 EMC89394.1 - 1.2e-05 25.7 0.0 2.6e-05 24.6 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) DUF316 PF03761.15 EMC89394.1 - 0.0072 15.9 0.0 0.13 11.8 0.0 2.4 3 0 0 3 3 3 1 Chymotrypsin family Peptidase-S1 WD40 PF00400.32 EMC89395.1 - 6.2e-13 49.0 21.9 2.9e-05 24.8 0.1 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat Zn_ribbon_17 PF17120.5 EMC89395.1 - 2.5e-11 43.0 15.5 2.5e-11 43.0 15.5 2.3 1 1 1 2 2 2 1 Zinc-ribbon, C4HC2 type zinc_ribbon_16 PF17034.5 EMC89395.1 - 3.5e-07 30.5 7.0 3.5e-07 30.5 7.0 2.4 1 1 1 2 2 2 1 Zinc-ribbon like family eIF2A PF08662.11 EMC89395.1 - 0.00092 19.1 0.9 0.048 13.5 0.2 2.6 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 EMC89395.1 - 0.03 14.6 0.7 4 7.8 0.0 3.5 1 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain zf-rbx1 PF12678.7 EMC89395.1 - 0.093 13.0 10.7 0.35 11.2 10.7 2.0 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EMC89395.1 - 0.46 10.9 14.6 0.031 14.6 5.5 3.1 2 0 0 2 2 2 0 Ring finger domain Pkinase_Tyr PF07714.17 EMC89396.1 - 2.2e-43 148.4 0.1 9.3e-41 139.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 EMC89396.1 - 1.7e-28 99.7 0.1 8.7e-28 97.4 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain RPW8 PF05659.11 EMC89396.1 - 0.0011 18.7 2.0 0.0011 18.7 2.0 2.2 2 0 0 2 2 2 1 Arabidopsis broad-spectrum mildew resistance protein RPW8 CENP-F_leu_zip PF10473.9 EMC89396.1 - 0.0067 16.5 0.2 0.0067 16.5 0.2 2.4 2 1 1 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ETF_QO PF05187.13 EMC89396.1 - 0.018 15.1 0.5 2.2 8.5 0.0 2.8 2 1 0 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Glu-tRNAGln PF02686.15 EMC89396.1 - 0.067 13.5 0.2 0.22 11.9 0.2 1.9 1 0 0 1 1 1 0 Glu-tRNAGln amidotransferase C subunit Cys_rich_FGFR PF00839.17 EMC89397.1 - 1.8e-202 655.7 116.3 2.1e-17 63.0 1.8 15.2 15 0 0 15 15 15 15 Cysteine rich repeat IFT43 PF15305.6 EMC89397.1 - 0.056 13.6 0.3 0.22 11.7 0.1 2.1 2 0 0 2 2 2 0 Intraflagellar transport protein 43 Tox-HDC PF15656.6 EMC89397.1 - 0.068 13.4 0.7 2.4 8.3 0.0 3.4 3 1 1 5 5 5 0 Toxin with a H, D/N and C signature DUF5314 PF17241.2 EMC89397.1 - 0.1 12.3 0.6 0.6 9.7 0.1 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5314) DUF445 PF04286.12 EMC89397.1 - 3.3 7.4 9.0 3.3 7.4 6.5 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF445) GCV_T PF01571.21 EMC89398.1 - 4.2e-66 223.0 0.0 6.4e-66 222.4 0.0 1.3 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain DAO PF01266.24 EMC89398.1 - 5.9e-59 200.4 0.0 8.7e-59 199.9 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAO_M PF16350.5 EMC89398.1 - 8.3e-15 54.9 0.0 2.3e-14 53.5 0.0 1.8 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain GCV_T_C PF08669.11 EMC89398.1 - 7.2e-13 48.3 0.0 2.2e-12 46.7 0.0 1.9 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain FAD_binding_2 PF00890.24 EMC89398.1 - 1e-07 31.4 0.8 3e-07 29.9 0.7 1.8 2 1 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EMC89398.1 - 1.2e-06 28.0 0.1 0.0071 15.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMC89398.1 - 1.9e-05 24.1 0.2 0.15 11.3 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GMC_oxred_N PF00732.19 EMC89398.1 - 4.7e-05 22.9 0.3 0.064 12.6 0.0 2.2 2 0 0 2 2 2 2 GMC oxidoreductase Trp_halogenase PF04820.14 EMC89398.1 - 0.00028 19.9 0.8 0.035 13.0 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase FAD_binding_3 PF01494.19 EMC89398.1 - 0.00065 19.0 1.8 0.0044 16.3 2.0 2.1 2 1 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EMC89398.1 - 0.0033 16.2 0.4 0.021 13.6 0.0 2.0 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 EMC89398.1 - 0.0037 16.7 1.4 0.0074 15.7 1.4 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EMC89398.1 - 0.0049 16.1 0.7 0.096 11.9 0.1 2.2 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 EMC89398.1 - 0.0077 16.4 0.2 0.028 14.6 0.2 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EMC89398.1 - 0.015 15.9 1.6 1.8 9.2 0.2 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EMC89398.1 - 0.073 13.3 0.1 0.15 12.3 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain ApbA PF02558.16 EMC89398.1 - 0.12 12.0 0.1 0.22 11.1 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.20 EMC89398.1 - 0.21 11.6 0.0 0.54 10.3 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Glyco_transf_29 PF00777.18 EMC89399.1 - 2.2e-81 273.2 0.0 2.6e-81 273.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) G_glu_transpept PF01019.21 EMC89399.1 - 0.0065 15.3 0.0 0.0087 14.9 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Fucokinase PF07959.12 EMC89400.1 - 1.3e-100 337.2 0.0 1.6e-100 336.9 0.0 1.1 1 0 0 1 1 1 1 L-fucokinase GHMP_kinases_C PF08544.13 EMC89400.1 - 2.3e-07 31.1 0.1 5.8e-07 29.8 0.1 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 EMC89400.1 - 4.3e-06 26.9 0.3 1.5e-05 25.2 0.3 1.9 1 0 0 1 1 1 1 GHMP kinases N terminal domain COG4 PF08318.12 EMC89401.1 - 8.1e-101 337.4 7.4 1.8e-100 336.3 7.4 1.6 1 0 0 1 1 1 1 COG4 transport protein RINT1_TIP1 PF04437.13 EMC89401.1 - 6.7e-05 22.0 1.5 0.0001 21.3 0.2 1.9 2 0 0 2 2 2 1 RINT-1 / TIP-1 family MeMO_Hyd_G PF02964.16 EMC89401.1 - 0.042 13.9 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 Methane monooxygenase, hydrolase gamma chain COG5 PF10392.9 EMC89401.1 - 0.59 10.3 6.1 2.4 8.3 0.2 3.2 2 1 1 3 3 3 0 Golgi transport complex subunit 5 GCP_C_terminal PF04130.13 EMC89401.1 - 1.4 8.3 6.6 1.3 8.4 3.5 2.4 2 1 0 2 2 2 0 Gamma tubulin complex component C-terminal MMS1_N PF10433.9 EMC89402.1 - 8.7e-184 611.7 0.0 3e-183 610.0 0.0 1.7 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EMC89402.1 - 2.5e-100 335.9 0.0 2.1e-98 329.6 0.0 2.5 2 0 0 2 2 2 2 CPSF A subunit region IL34 PF15036.6 EMC89403.1 - 8.9e-45 152.6 3.1 9.7e-45 152.4 3.1 1.0 1 0 0 1 1 1 1 Interleukin 34 IMD PF08397.11 EMC89404.1 - 5.8e-99 329.9 2.0 8.3e-99 329.4 2.0 1.2 1 0 0 1 1 1 1 IRSp53/MIM homology domain Vac14_Fig4_bd PF11916.8 EMC89405.1 - 3.2e-79 264.7 9.7 5.5e-79 264.0 9.7 1.4 1 0 0 1 1 1 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 EMC89405.1 - 1.3e-45 154.0 0.2 4.1e-40 136.3 0.0 4.3 3 1 1 4 4 4 2 Vacuolar 14 Fab1-binding region HEAT PF02985.22 EMC89405.1 - 5.3e-08 32.5 0.4 0.016 15.4 0.0 4.9 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.6 EMC89405.1 - 2.2e-06 28.0 0.1 0.3 11.6 0.0 4.8 5 0 0 5 5 5 2 HEAT-like repeat Cnd1 PF12717.7 EMC89405.1 - 0.00088 19.4 1.9 0.85 9.6 0.1 3.7 3 1 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EMC89405.1 - 0.0034 17.7 0.0 42 4.6 0.0 4.1 3 2 0 3 3 3 0 HEAT repeats SPAR_C PF11881.8 EMC89405.1 - 0.083 12.8 2.6 0.61 10.0 0.9 2.3 2 0 0 2 2 2 0 C-terminal domain of SPAR protein ASH PF15780.5 EMC89406.1 - 6.7e-13 48.7 0.0 0.00017 21.7 0.0 3.5 3 0 0 3 3 3 3 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Motile_Sperm PF00635.26 EMC89406.1 - 1e-07 31.8 0.1 0.00083 19.2 0.0 2.9 3 0 0 3 3 3 2 MSP (Major sperm protein) domain DUF1573 PF07610.11 EMC89406.1 - 5.7e-06 26.3 0.0 0.39 10.8 0.0 3.4 3 0 0 3 3 3 3 Protein of unknown function (DUF1573) MYCBPAP PF14646.6 EMC89406.1 - 5.7e-06 25.5 4.1 0.18 10.7 1.0 3.8 2 1 1 3 3 3 3 MYCBP-associated protein family PapD-like PF14874.6 EMC89406.1 - 0.11 12.6 0.0 1.3 9.2 0.0 2.3 2 0 0 2 2 2 0 Flagellar-associated PapD-like PNP_UDP_1 PF01048.20 EMC89407.1 - 8.1e-49 166.0 0.0 9.1e-49 165.8 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily EF-hand_1 PF00036.32 EMC89408.1 - 5.8e-26 88.1 4.3 1.9e-06 27.0 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EMC89408.1 - 3e-23 79.7 4.0 5.4e-06 25.9 0.0 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 EMC89408.1 - 7.7e-22 77.5 3.2 5.8e-10 39.5 0.7 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EMC89408.1 - 1.4e-18 65.5 2.1 0.001 18.5 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EMC89408.1 - 4.1e-08 32.9 3.5 0.014 15.2 0.2 4.1 2 1 1 3 3 3 3 EF-hand domain pair GPHH PF16905.5 EMC89408.1 - 0.00012 21.8 0.0 1.9 8.3 0.0 3.2 3 0 0 3 3 3 2 Voltage-dependent L-type calcium channel, IQ-associated Dockerin_1 PF00404.18 EMC89408.1 - 0.00029 20.9 0.1 2.3 8.5 0.2 3.3 3 1 0 3 3 3 2 Dockerin type I domain EF-hand_10 PF14788.6 EMC89408.1 - 0.00038 20.2 0.6 0.78 9.7 0.1 3.8 4 1 0 4 4 4 1 EF hand SPARC_Ca_bdg PF10591.9 EMC89408.1 - 0.078 13.3 0.2 15 6.0 0.1 3.3 1 1 2 3 3 2 0 Secreted protein acidic and rich in cysteine Ca binding region WWE PF02825.20 EMC89408.1 - 0.083 13.5 0.2 1.5 9.5 0.0 2.6 2 1 0 2 2 2 0 WWE domain Caleosin PF05042.13 EMC89408.1 - 0.11 12.4 1.3 1.8 8.4 0.2 2.9 2 1 1 3 3 3 0 Caleosin related protein Aa_trans PF01490.18 EMC89409.1 - 1e-55 189.2 23.8 1.2e-55 188.9 23.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EMC89409.1 - 4.1e-07 29.4 21.8 1e-06 28.1 15.7 2.3 2 0 0 2 2 2 2 Tryptophan/tyrosine permease family Spore_permease PF03845.13 EMC89409.1 - 0.14 10.9 23.0 0.01 14.7 5.8 2.5 3 0 0 3 3 3 0 Spore germination protein Rubis-subs-bind PF09273.11 EMC89411.1 - 1.3e-17 64.7 2.4 1.8e-17 64.3 2.4 1.2 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding YlbD_coat PF14071.6 EMC89411.1 - 0.058 13.7 1.4 0.11 12.7 1.4 1.5 1 0 0 1 1 1 0 Putative coat protein SET PF00856.28 EMC89411.1 - 0.14 12.5 0.7 1.1 9.6 0.0 2.2 2 1 0 2 2 2 0 SET domain Pkinase PF00069.25 EMC89412.1 - 8.8e-74 248.2 0.0 1.5e-73 247.4 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC89412.1 - 1.1e-41 142.8 0.0 1.5e-41 142.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC89412.1 - 1.2e-08 34.7 0.0 1.9e-07 30.7 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EMC89412.1 - 0.0096 15.3 0.2 0.014 14.7 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EMC89412.1 - 0.013 14.4 0.1 0.018 14.0 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain UBA PF00627.31 EMC89412.1 - 0.068 13.1 0.2 0.27 11.2 0.0 2.1 3 0 0 3 3 3 0 UBA/TS-N domain vATP-synt_AC39 PF01992.16 EMC89413.1 - 1.2e-115 386.6 0.2 1.3e-115 386.5 0.2 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Nab2p_Zf1 PF18260.1 EMC89413.1 - 0.065 13.2 0.6 0.29 11.1 0.0 2.2 2 0 0 2 2 2 0 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 adh_short PF00106.25 EMC89414.1 - 1.4e-43 148.6 0.0 2.1e-43 148.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC89414.1 - 1.4e-27 96.8 0.0 2.1e-27 96.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC89414.1 - 7.3e-05 22.7 0.0 0.00012 22.1 0.0 1.2 1 0 0 1 1 1 1 KR domain NmrA PF05368.13 EMC89414.1 - 0.089 12.3 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family DUF1776 PF08643.10 EMC89414.1 - 0.14 11.5 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Na_H_Exchanger PF00999.21 EMC89415.1 - 2.7e-64 217.4 30.6 3.2e-64 217.1 30.6 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family NEXCaM_BD PF16644.5 EMC89415.1 - 2e-05 24.8 3.6 5e-05 23.5 3.6 1.6 1 0 0 1 1 1 1 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin PIG-H PF10181.9 EMC89415.1 - 0.47 10.3 6.2 0.042 13.7 0.8 2.1 2 0 0 2 2 2 0 GPI-GlcNAc transferase complex, PIG-H component p25-alpha PF05517.12 EMC89416.1 - 1.7e-66 223.2 8.9 2e-66 223.0 8.9 1.0 1 0 0 1 1 1 1 p25-alpha DnaB PF00772.21 EMC89416.1 - 0.011 15.8 0.0 0.019 15.1 0.0 1.5 1 1 0 1 1 1 0 DnaB-like helicase N terminal domain EGF_CA PF07645.15 EMC89418.1 - 3.4e-16 59.2 48.3 2.2e-07 30.9 7.3 5.7 5 2 1 6 6 6 4 Calcium-binding EGF domain EGF PF00008.27 EMC89418.1 - 1.4e-13 50.8 20.3 5e-10 39.5 8.0 6.5 7 1 0 7 7 7 2 EGF-like domain cEGF PF12662.7 EMC89418.1 - 1.9e-12 46.9 32.1 4e-09 36.2 0.7 6.2 6 0 0 6 6 6 3 Complement Clr-like EGF-like Sushi PF00084.20 EMC89418.1 - 1.2e-09 38.6 0.3 1.2e-09 38.6 0.3 4.3 5 0 0 5 5 5 1 Sushi repeat (SCR repeat) hEGF PF12661.7 EMC89418.1 - 4.7e-09 36.5 16.3 4.7e-07 30.2 6.8 7.3 8 0 0 8 8 8 3 Human growth factor-like EGF FXa_inhibition PF14670.6 EMC89418.1 - 6.1e-09 36.0 44.9 5.2e-07 29.8 4.5 5.3 4 1 1 5 5 5 3 Coagulation Factor Xa inhibitory site EGF_2 PF07974.13 EMC89418.1 - 0.0028 18.0 13.5 0.0028 18.0 13.5 5.4 6 0 0 6 6 6 1 EGF-like domain EGF_3 PF12947.7 EMC89418.1 - 0.98 9.7 0.0 0.98 9.7 0.0 6.1 6 1 1 7 7 7 0 EGF domain RRM_1 PF00076.22 EMC89419.1 - 5.1e-07 29.4 0.0 9e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc PF12871.7 EMC89419.1 - 0.0038 17.8 50.1 0.0088 16.6 50.1 1.6 1 0 0 1 1 1 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Lys PF00062.20 EMC89420.1 - 1.9e-05 24.9 2.0 0.00046 20.4 2.0 2.0 1 1 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family YEATS PF03366.16 EMC89421.1 - 4.7e-34 116.2 0.4 8.2e-34 115.4 0.4 1.4 1 0 0 1 1 1 1 YEATS family SOGA PF11365.8 EMC89421.1 - 0.0073 17.4 3.0 0.014 16.5 3.0 1.5 1 0 0 1 1 1 1 Protein SOGA DUF1664 PF07889.12 EMC89421.1 - 0.2 11.7 1.1 0.32 11.1 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) IRS PF02174.17 EMC89422.1 - 8.8e-25 86.5 0.1 1.9e-24 85.4 0.1 1.5 1 0 0 1 1 1 1 PTB domain (IRS-1 type) Exo_endo_phos PF03372.23 EMC89423.1 - 2.1e-17 63.4 0.0 2.7e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Glyco_hydro_cc PF11790.8 EMC89423.1 - 0.002 17.7 1.1 1.5 8.3 0.1 2.4 2 0 0 2 2 2 2 Glycosyl hydrolase catalytic core OLF PF02191.16 EMC89423.1 - 0.029 13.9 0.7 0.051 13.1 0.7 1.4 1 0 0 1 1 1 0 Olfactomedin-like domain 7tm_1 PF00001.21 EMC89424.1 - 1.3e-46 159.1 11.7 1.5e-46 158.8 11.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC89424.1 - 1.1e-07 31.5 8.8 1.3e-07 31.3 8.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 EMC89424.1 - 1.7e-07 30.9 4.2 2.1e-07 30.6 4.0 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srw PF10324.9 EMC89424.1 - 5.7e-05 22.5 6.5 0.00028 20.3 6.5 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.6 EMC89424.1 - 0.0013 18.5 9.2 0.018 14.8 9.2 2.0 1 1 0 1 1 1 1 Olfactory receptor 7tm_2 PF00002.24 EMC89424.1 - 0.98 8.7 12.5 5.6 6.2 12.5 1.9 1 1 0 1 1 1 0 7 transmembrane receptor (Secretin family) HrpB4 PF09502.10 EMC89425.1 - 0.046 13.5 0.1 0.069 13.0 0.1 1.2 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB4) AraC_binding_2 PF14525.6 EMC89426.1 - 0.0018 18.0 6.1 18 5.0 0.1 4.2 1 1 3 4 4 4 4 AraC-binding-like domain Cornifin PF02389.15 EMC89427.1 - 7.5e-06 26.2 54.0 0.0035 17.5 31.6 2.0 1 1 1 2 2 2 2 Cornifin (SPRR) family DUF1619 PF07773.11 EMC89428.1 - 9e-33 114.5 0.2 1.3e-31 110.7 0.0 1.9 1 1 1 2 2 2 2 Protein of unknown function (DUF1619) M16C_assoc PF08367.11 EMC89429.1 - 1.7e-86 289.5 0.0 2.8e-86 288.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 EMC89429.1 - 6.1e-30 104.6 1.0 1.5e-21 77.2 0.0 2.8 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EMC89429.1 - 7.8e-10 38.9 0.4 1.3e-05 25.2 0.0 3.8 5 0 0 5 5 5 2 Insulinase (Peptidase family M16) KMP11 PF03037.16 EMC89429.1 - 4.8 8.0 10.3 1.2 10.0 2.7 3.2 3 0 0 3 3 3 0 Kinetoplastid membrane protein 11 zf-C2H2 PF00096.26 EMC89430.1 - 9.2e-14 51.0 31.7 7.9e-05 22.9 8.9 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC89430.1 - 3e-10 40.0 13.7 1.8e-06 28.1 6.5 3.8 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC89430.1 - 1.8e-06 28.3 28.4 0.009 16.8 7.1 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger DUF3850 PF12961.7 EMC89430.1 - 0.075 13.1 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3850) zf-C2H2_8 PF15909.5 EMC89430.1 - 1 9.7 11.6 0.37 11.1 6.7 2.6 2 1 1 3 3 3 0 C2H2-type zinc ribbon DUF4692 PF15763.5 EMC89430.1 - 1.6 9.1 6.6 2 8.9 5.5 1.6 1 1 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) FOXP-CC PF16159.5 EMC89430.1 - 1.7 9.3 9.3 1.3 9.7 0.8 2.8 1 1 2 3 3 3 0 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 EMC89430.1 - 2.9 8.3 9.1 8.1 6.9 1.7 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Connexin PF00029.19 EMC89432.1 - 4.2e-67 226.3 12.0 1.3e-36 126.6 1.0 2.2 1 1 0 2 2 2 2 Connexin Cyclin_N PF00134.23 EMC89433.1 - 1e-14 54.4 0.1 1.7e-14 53.7 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EMC89433.1 - 1.1e-11 45.4 0.1 1.4e-11 45.0 0.1 1.3 1 0 0 1 1 1 1 Cyclin bZIP_1 PF00170.21 EMC89434.1 - 1.4e-20 73.2 11.9 2.3e-20 72.5 11.9 1.3 1 0 0 1 1 1 1 bZIP transcription factor pKID PF02173.17 EMC89434.1 - 3e-18 65.0 3.6 7.9e-18 63.6 3.6 1.7 1 0 0 1 1 1 1 pKID domain bZIP_2 PF07716.15 EMC89434.1 - 2.3e-07 30.8 11.0 4.1e-07 30.0 11.0 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EMC89434.1 - 0.0026 18.2 6.2 0.0051 17.3 6.2 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor Cadherin_tail PF15974.5 EMC89434.1 - 3.2 8.1 6.7 7.8 6.8 0.3 3.2 2 1 0 3 3 3 0 Cadherin C-terminal cytoplasmic tail, catenin-binding region Par3_HAL_N_term PF12053.8 EMC89435.1 - 1.4e-40 137.4 1.2 5.6e-40 135.4 1.2 2.2 1 0 0 1 1 1 1 N-terminal of Par3 and HAL proteins PDZ PF00595.24 EMC89435.1 - 1.1e-37 128.2 4.6 7.2e-16 58.3 0.1 3.6 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 EMC89435.1 - 3.9e-19 68.2 0.0 2.7e-07 30.3 0.0 3.6 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 EMC89435.1 - 1.5e-15 57.3 0.7 8.3e-07 29.2 0.1 3.9 3 1 0 3 3 3 3 PDZ domain TPR_11 PF13414.6 EMC89435.1 - 0.11 12.2 0.2 0.22 11.2 0.2 1.5 1 0 0 1 1 1 0 TPR repeat Integrin_beta PF00362.18 EMC89436.1 - 5.3e-116 386.6 0.1 7.2e-116 386.1 0.1 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.11 EMC89436.1 - 4.4e-23 80.7 0.4 7.9e-23 79.9 0.4 1.4 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.12 EMC89436.1 - 2.4e-22 79.2 7.7 2.4e-22 79.2 7.7 4.5 6 0 0 6 6 6 1 Integrin beta tail domain PSI_integrin PF17205.3 EMC89436.1 - 8.8e-13 47.8 7.5 8.8e-13 47.8 7.5 4.3 3 1 0 3 3 3 1 Integrin plexin domain I-EGF_1 PF18372.1 EMC89436.1 - 5.2e-12 45.6 12.5 5.2e-12 45.6 12.5 7.1 9 0 0 9 9 9 3 Integrin beta epidermal growth factor like domain 1 EGF_2 PF07974.13 EMC89436.1 - 3.4e-08 33.7 59.7 6.8e-06 26.3 16.5 6.8 6 1 0 6 6 6 3 EGF-like domain E_Pc_C PF06752.12 EMC89437.1 - 8.8e-98 327.0 41.9 8.8e-98 327.0 41.9 2.3 2 1 0 2 2 2 1 Enhancer of Polycomb C-terminus EPL1 PF10513.9 EMC89437.1 - 4.5e-06 27.1 0.7 4.5e-06 27.1 0.7 3.5 5 0 0 5 5 5 1 Enhancer of polycomb-like CAF1A PF12253.8 EMC89437.1 - 0.098 12.8 0.6 0.44 10.7 0.1 2.3 2 0 0 2 2 2 0 Chromatin assembly factor 1 subunit A SH3-WW_linker PF16618.5 EMC89438.1 - 1.6e-55 188.6 13.4 1.6e-55 188.6 13.4 3.7 4 1 0 4 4 4 1 Linker region between SH3 and WW domains on ARHGAP12 RhoGAP PF00620.27 EMC89438.1 - 1.8e-50 170.7 0.1 3.8e-50 169.7 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 EMC89438.1 - 9.6e-10 38.9 0.5 5.3e-09 36.5 0.5 2.3 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.28 EMC89438.1 - 7.2e-06 25.5 0.9 0.00014 21.3 0.2 2.6 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EMC89438.1 - 1.1e-05 25.2 0.0 3.1e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain PH_9 PF15410.6 EMC89438.1 - 3.7e-05 24.1 0.4 0.00012 22.4 0.4 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain WW PF00397.26 EMC89438.1 - 7.3e-05 22.8 25.6 0.00086 19.3 5.5 4.4 3 1 1 4 4 4 2 WW domain SH3_10 PF17902.1 EMC89438.1 - 0.029 14.5 0.1 0.1 12.7 0.1 2.0 1 0 0 1 1 1 0 SH3 domain Glyco_hyd_101C PF17451.2 EMC89438.1 - 0.85 9.9 14.0 0.84 9.9 0.5 4.0 5 0 0 5 5 5 0 Glycosyl hydrolase 101 beta sandwich domain zf-H2C2_2 PF13465.6 EMC89439.1 - 2.2e-30 103.7 54.6 6.3e-08 32.7 2.5 7.8 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.26 EMC89439.1 - 4.1e-24 83.6 66.3 0.00011 22.5 5.0 7.8 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC89439.1 - 2.7e-14 52.6 64.1 0.029 15.2 4.4 8.1 8 0 0 8 8 8 7 C2H2-type zinc finger zf-met PF12874.7 EMC89439.1 - 5e-09 36.3 46.1 0.016 15.6 1.2 6.8 6 0 0 6 6 6 5 Zinc-finger of C2H2 type zf-Di19 PF05605.12 EMC89439.1 - 1.3e-08 35.0 26.0 1.5e-07 31.6 1.3 3.9 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 EMC89439.1 - 1.2e-07 31.8 54.6 0.0091 16.3 1.9 7.9 8 0 0 8 8 7 5 Zinc-finger double-stranded RNA-binding Homeodomain PF00046.29 EMC89439.1 - 4e-05 23.4 0.0 0.0001 22.1 0.0 1.7 1 0 0 1 1 1 1 Homeodomain zf-C2H2_6 PF13912.6 EMC89439.1 - 0.016 15.2 60.9 0.52 10.4 0.9 7.5 7 0 0 7 7 7 0 C2H2-type zinc finger zf-C2HE PF16278.5 EMC89439.1 - 0.082 13.4 0.1 0.082 13.4 0.1 6.9 3 2 2 5 5 4 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_9 PF16293.5 EMC89439.1 - 0.17 11.8 15.8 5.2 7.0 0.0 5.3 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.7 EMC89439.1 - 2.3 8.6 45.7 0.077 13.3 1.1 6.9 3 2 3 6 6 6 0 C2H2 type zinc-finger (2 copies) RVT_1 PF00078.27 EMC89441.1 - 0.003 17.1 0.0 0.0045 16.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2_2 PF13465.6 EMC89443.1 - 4.8e-08 33.1 30.4 0.00013 22.2 3.6 5.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC89443.1 - 0.00072 20.2 48.6 0.024 15.4 3.3 5.7 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2 PF00096.26 EMC89443.1 - 0.027 14.9 4.1 0.027 14.9 4.1 5.0 5 0 0 5 5 5 0 Zinc finger, C2H2 type JCAD PF15351.6 EMC89444.1 - 0 1754.8 63.8 0 1749.0 63.8 2.0 1 1 0 1 1 1 1 Junctional protein associated with coronary artery disease RL PF17797.1 EMC89445.1 - 1.6e-33 114.5 0.3 3e-33 113.6 0.3 1.5 1 0 0 1 1 1 1 RL domain PAP_assoc PF03828.19 EMC89445.1 - 5.8e-05 23.2 0.2 0.00017 21.7 0.2 1.8 1 0 0 1 1 1 1 Cid1 family poly A polymerase ELM2 PF01448.24 EMC89445.1 - 0.045 14.5 0.2 3.1 8.6 0.0 2.7 3 0 0 3 3 3 0 ELM2 domain DUF3939 PF13075.6 EMC89445.1 - 0.08 13.0 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3939) Pkinase PF00069.25 EMC89446.1 - 7.6e-49 166.4 0.0 1.3e-48 165.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC89446.1 - 2.3e-25 89.4 0.0 4.9e-25 88.3 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC89446.1 - 1.7e-05 23.8 0.0 2.2e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMC89446.1 - 0.012 15.5 0.1 0.027 14.4 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EMC89446.1 - 0.044 13.1 0.0 6.6 5.9 0.0 2.2 2 0 0 2 2 2 0 Kinase-like RIO1 PF01163.22 EMC89446.1 - 0.082 12.5 0.1 0.24 11.0 0.1 1.8 1 1 1 2 2 2 0 RIO1 family BAMBI PF06211.12 EMC89447.1 - 1.5e-46 157.1 11.1 1.5e-46 157.1 11.1 1.5 2 0 0 2 2 2 1 BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain LapA_dom PF06305.11 EMC89447.1 - 0.049 13.5 0.9 0.074 12.9 0.9 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain EphA2_TM PF14575.6 EMC89447.1 - 0.079 13.8 0.0 0.17 12.8 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain KASH PF10541.9 EMC89447.1 - 1.2 9.4 4.2 6.2 7.2 0.2 2.5 2 0 0 2 2 2 0 Nuclear envelope localisation domain WW PF00397.26 EMC89448.1 - 1.5e-09 37.7 1.1 3.3e-09 36.7 1.1 1.5 1 0 0 1 1 1 1 WW domain Tropomyosin PF00261.20 EMC89449.1 - 0.00048 19.6 4.9 0.00058 19.3 4.9 1.1 1 0 0 1 1 1 1 Tropomyosin Filament PF00038.21 EMC89449.1 - 0.00092 18.9 6.0 0.0011 18.7 6.0 1.1 1 0 0 1 1 1 1 Intermediate filament protein DUF2968 PF11180.8 EMC89449.1 - 0.0011 18.7 4.6 0.0013 18.4 4.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2968) ADIP PF11559.8 EMC89449.1 - 0.0021 18.2 7.7 0.0025 17.9 7.7 1.2 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding HMMR_N PF15905.5 EMC89449.1 - 0.0022 17.6 11.4 0.0026 17.3 11.4 1.0 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal TACC_C PF05010.14 EMC89449.1 - 0.0034 17.2 7.5 0.041 13.7 3.8 2.0 1 1 1 2 2 2 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Seryl_tRNA_N PF02403.22 EMC89449.1 - 0.0054 16.9 8.8 0.025 14.8 0.7 2.0 1 1 1 2 2 2 2 Seryl-tRNA synthetase N-terminal domain Baculo_gp41 PF04700.12 EMC89449.1 - 0.0072 16.1 0.4 0.0081 15.9 0.4 1.2 1 0 0 1 1 1 1 Structural glycoprotein p40/gp41 conserved region GAS PF13851.6 EMC89449.1 - 0.0079 15.6 11.3 0.16 11.3 9.4 1.9 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 EMC89449.1 - 0.012 16.2 11.3 0.016 15.8 10.8 1.5 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF3450 PF11932.8 EMC89449.1 - 0.014 14.7 5.4 0.017 14.4 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Bacillus_HBL PF05791.11 EMC89449.1 - 0.016 15.1 4.4 0.023 14.5 4.4 1.4 1 1 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) TMF_TATA_bd PF12325.8 EMC89449.1 - 0.018 15.3 6.5 0.023 14.9 6.5 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Cortex-I_coil PF09304.10 EMC89449.1 - 0.019 15.2 5.4 0.022 15.0 5.4 1.2 1 0 0 1 1 1 0 Cortexillin I, coiled coil DUF812 PF05667.11 EMC89449.1 - 0.023 13.6 7.9 0.027 13.4 7.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Prefoldin_3 PF13758.6 EMC89449.1 - 0.023 14.7 2.3 0.035 14.1 2.3 1.4 1 1 0 1 1 1 0 Prefoldin subunit DUF3523 PF12037.8 EMC89449.1 - 0.027 13.9 5.2 0.03 13.7 5.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) TPR_MLP1_2 PF07926.12 EMC89449.1 - 0.036 14.1 9.5 0.11 12.5 8.4 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF948 PF06103.11 EMC89449.1 - 0.046 14.0 3.0 0.72 10.1 1.2 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Spc7 PF08317.11 EMC89449.1 - 0.059 12.2 11.1 0.64 8.8 6.2 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF5320 PF17253.2 EMC89449.1 - 0.065 14.3 1.1 0.12 13.5 1.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5320) Herpes_UL6 PF01763.16 EMC89449.1 - 0.069 11.7 3.7 0.079 11.5 3.7 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like SseC PF04888.12 EMC89449.1 - 0.096 12.3 2.5 0.12 12.0 2.5 1.1 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DrrA_P4M PF14860.6 EMC89449.1 - 0.12 12.2 5.7 0.19 11.6 3.4 2.0 1 1 1 2 2 2 0 DrrA phosphatidylinositol 4-phosphate binding domain Takusan PF04822.13 EMC89449.1 - 0.13 12.1 8.0 1.4 8.9 0.3 2.4 1 1 1 2 2 2 0 Takusan YabA PF06156.13 EMC89449.1 - 0.14 12.8 6.8 0.22 12.2 6.7 1.4 1 1 0 1 1 1 0 Initiation control protein YabA UPF0242 PF06785.11 EMC89449.1 - 0.17 12.0 7.5 0.2 11.7 7.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Spore_III_AB PF09548.10 EMC89449.1 - 0.18 11.9 5.6 0.82 9.8 2.8 2.0 1 1 1 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Prefoldin PF02996.17 EMC89449.1 - 0.19 11.6 7.4 0.12 12.3 4.7 1.9 1 1 1 2 2 2 0 Prefoldin subunit bZIP_Maf PF03131.17 EMC89449.1 - 0.22 12.0 6.5 0.24 12.0 5.3 1.7 1 1 0 1 1 1 0 bZIP Maf transcription factor FapA PF03961.13 EMC89449.1 - 0.23 10.0 6.8 0.24 9.9 6.8 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A H-kinase_dim PF02895.14 EMC89449.1 - 0.23 11.9 2.8 0.75 10.2 2.8 1.9 1 1 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain DUF1640 PF07798.11 EMC89449.1 - 0.4 10.7 8.0 0.74 9.8 8.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) TMPIT PF07851.13 EMC89449.1 - 0.41 9.9 4.2 0.45 9.7 4.2 1.1 1 0 0 1 1 1 0 TMPIT-like protein CREPT PF16566.5 EMC89449.1 - 0.52 10.5 8.3 0.72 10.0 7.9 1.4 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour DUF1043 PF06295.12 EMC89449.1 - 0.64 10.0 6.1 0.86 9.6 5.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) HALZ PF02183.18 EMC89449.1 - 0.68 10.2 8.0 20 5.5 6.7 3.2 2 1 1 3 3 3 0 Homeobox associated leucine zipper DUF1664 PF07889.12 EMC89449.1 - 0.93 9.5 5.1 1.2 9.2 4.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) JIP_LZII PF16471.5 EMC89449.1 - 1 9.6 10.4 1.5 9.1 8.6 2.2 1 1 0 1 1 1 0 JNK-interacting protein leucine zipper II SlyX PF04102.12 EMC89449.1 - 1.3 9.7 7.7 3.5 8.3 7.1 2.0 1 1 1 2 2 2 0 SlyX DUF4140 PF13600.6 EMC89449.1 - 1.6 9.2 5.6 3.1 8.3 5.6 1.7 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Spc24 PF08286.11 EMC89449.1 - 1.7 9.0 8.0 3.3 8.0 8.1 1.7 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 DivIC PF04977.15 EMC89449.1 - 2.8 7.8 11.1 2.5 7.9 8.2 2.3 1 1 2 3 3 3 0 Septum formation initiator ABC_tran_CTD PF16326.5 EMC89449.1 - 3.3 8.0 10.3 1.5 9.1 5.7 2.0 1 1 1 2 2 2 0 ABC transporter C-terminal domain Guanylate_kin PF00625.21 EMC89450.1 - 2e-50 171.0 0.3 5.3e-49 166.4 0.3 2.3 1 1 0 1 1 1 1 Guanylate kinase L27 PF02828.16 EMC89450.1 - 5e-26 90.2 6.4 2.6e-13 49.5 1.9 2.5 2 0 0 2 2 2 2 L27 domain PDZ PF00595.24 EMC89450.1 - 2.1e-12 47.2 1.0 4.6e-12 46.1 1.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC89450.1 - 9e-10 38.2 0.2 4.7e-09 36.0 0.2 2.2 2 0 0 2 2 2 1 PDZ domain SH3_2 PF07653.17 EMC89450.1 - 2.9e-07 30.1 0.0 7.7e-07 28.7 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC89450.1 - 6.8e-07 28.8 0.4 5.3e-06 25.9 0.3 2.5 2 1 0 2 2 2 1 SH3 domain PDZ_2 PF13180.6 EMC89450.1 - 7.1e-05 23.1 0.1 0.00025 21.3 0.1 2.0 1 0 0 1 1 1 1 PDZ domain SH3_9 PF14604.6 EMC89450.1 - 0.00059 19.6 0.0 0.0016 18.2 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Homeobox_KN PF05920.11 EMC89451.1 - 1.4e-14 53.7 0.3 2.7e-14 52.8 0.3 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EMC89451.1 - 3.3e-05 23.7 0.2 8.2e-05 22.4 0.2 1.7 1 0 0 1 1 1 1 Homeodomain zf-H2C2_2 PF13465.6 EMC89453.1 - 1.6e-12 47.2 6.1 4.8e-06 26.7 1.3 2.1 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.26 EMC89453.1 - 4.3e-07 30.0 0.6 4.3e-07 30.0 0.6 3.1 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-LYAR PF08790.11 EMC89453.1 - 0.00011 22.1 4.9 0.0021 17.9 0.4 2.4 2 0 0 2 2 2 2 LYAR-type C2HC zinc finger zf-C2HE PF16278.5 EMC89453.1 - 0.0003 21.2 1.2 0.19 12.2 0.2 2.2 2 0 0 2 2 2 2 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_4 PF13894.6 EMC89453.1 - 0.0018 19.0 0.3 0.0018 19.0 0.3 3.1 3 0 0 3 3 3 1 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 EMC89453.1 - 0.002 18.2 1.0 0.0033 17.5 1.0 1.3 1 0 0 1 1 1 1 Zinc ribbon domain zf-HYPF PF07503.12 EMC89453.1 - 0.0049 16.6 2.2 1.2 9.0 0.1 2.2 2 0 0 2 2 2 2 HypF finger zf-trcl PF13451.6 EMC89453.1 - 0.014 15.3 1.9 0.52 10.2 0.1 2.1 2 0 0 2 2 2 0 Probable zinc-ribbon domain zf_UBZ PF18439.1 EMC89453.1 - 0.021 14.4 2.9 0.54 9.9 0.1 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Chordopox_RPO7 PF05864.12 EMC89453.1 - 0.026 14.8 1.4 0.081 13.2 1.2 1.9 1 1 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) HypA PF01155.19 EMC89453.1 - 0.027 14.5 0.2 0.03 14.4 0.2 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-Mss51 PF13824.6 EMC89453.1 - 0.048 13.7 1.9 0.76 9.9 0.3 2.1 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 YhfH PF14149.6 EMC89453.1 - 0.05 13.6 1.8 3.3 7.8 0.0 2.2 2 0 0 2 2 2 0 YhfH-like protein LIM PF00412.22 EMC89453.1 - 0.12 12.7 4.3 0.18 12.0 0.2 2.1 1 1 1 2 2 2 0 LIM domain zf-C2H2_jaz PF12171.8 EMC89453.1 - 0.68 10.3 6.5 11 6.5 0.1 3.0 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-AN1 PF01428.16 EMC89453.1 - 6.7 7.0 11.7 8.6 6.6 3.7 2.6 1 1 2 3 3 3 0 AN1-like Zinc finger SWIB PF02201.18 EMC89454.1 - 1.6e-24 85.6 0.2 4.2e-24 84.2 0.2 1.8 1 0 0 1 1 1 1 SWIB/MDM2 domain Pkinase PF00069.25 EMC89455.1 - 5.4e-54 183.3 0.0 8.5e-54 182.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC89455.1 - 8.4e-36 123.6 0.0 1.2e-35 123.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMC89455.1 - 0.0005 19.0 0.0 0.0013 17.6 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EMC89455.1 - 0.032 13.6 0.0 0.053 12.8 0.0 1.3 1 0 0 1 1 1 0 Kinase-like UPF0020 PF01170.18 EMC89456.1 - 0.021 14.5 0.0 0.041 13.6 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 SpvD PF05563.12 EMC89456.1 - 0.15 11.7 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 Salmonella plasmid virulence protein SpvD Methyltransf_11 PF08241.12 EMC89456.1 - 0.17 12.5 0.1 1 10.1 0.1 2.2 1 1 0 1 1 1 0 Methyltransferase domain GDPD PF03009.17 EMC89457.1 - 9.5e-64 215.6 0.1 1.8e-63 214.7 0.1 1.4 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family CBM_20 PF00686.19 EMC89457.1 - 7.5e-10 38.6 0.0 2.6e-09 36.9 0.0 1.9 2 0 0 2 2 2 1 Starch binding domain PI-PLC-X PF00388.19 EMC89457.1 - 0.064 12.8 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain Nup54_57_C PF18570.1 EMC89457.1 - 0.26 10.9 1.8 0.66 9.6 1.8 1.7 1 0 0 1 1 1 0 NUP57/Nup54 C-terminal domain DUF737 PF05300.11 EMC89458.1 - 6.6e-09 36.4 0.0 7e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF737) Sec8_exocyst PF04048.14 EMC89459.1 - 4.2e-19 68.8 4.0 5.5e-19 68.5 1.5 2.1 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain Zw10 PF06248.13 EMC89459.1 - 4.7e-06 25.4 7.8 4.7e-06 25.4 7.8 1.9 2 0 0 2 2 2 1 Centromere/kinetochore Zw10 Vps54_N PF10475.9 EMC89459.1 - 0.0008 18.8 6.2 0.0008 18.8 6.2 2.0 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex COG5 PF10392.9 EMC89459.1 - 0.0012 19.0 2.2 0.0012 19.0 2.2 3.2 2 1 1 3 3 3 1 Golgi transport complex subunit 5 Dor1 PF04124.12 EMC89459.1 - 0.008 14.9 11.6 0.0051 15.6 6.5 2.1 2 0 0 2 2 2 1 Dor1-like family EzrA PF06160.12 EMC89459.1 - 0.032 12.4 7.3 0.027 12.7 3.2 2.1 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA PEP-utilisers_N PF05524.13 EMC89459.1 - 0.034 14.3 0.2 0.11 12.6 0.0 2.0 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal AAA_14 PF13173.6 EMC89459.1 - 0.067 13.2 0.9 0.57 10.2 0.1 2.5 1 1 1 3 3 3 0 AAA domain T3SS_needle_E PF08988.10 EMC89459.1 - 0.11 12.6 1.9 2.6 8.3 0.2 3.0 2 1 1 3 3 3 0 Type III secretion system, cytoplasmic E component of needle Ead_Ea22 PF13935.6 EMC89459.1 - 0.12 13.1 2.4 0.51 11.0 0.9 2.5 2 1 1 3 3 3 0 Ead/Ea22-like protein Prominin PF05478.11 EMC89459.1 - 0.25 9.3 6.9 0.32 8.9 2.8 2.1 2 0 0 2 2 2 0 Prominin Vps51 PF08700.11 EMC89459.1 - 0.7 10.0 8.0 1.8 8.7 1.3 3.0 3 0 0 3 3 3 0 Vps51/Vps67 DASH_Duo1 PF08651.10 EMC89459.1 - 1.3 8.9 6.9 2.5 8.0 0.5 2.8 3 0 0 3 3 3 0 DASH complex subunit Duo1 Cauli_AT PF03233.13 EMC89459.1 - 1.8 8.4 8.6 0.28 11.1 0.7 2.6 3 0 0 3 3 3 0 Aphid transmission protein 5_3_exonuc PF01367.20 EMC89459.1 - 4.4 8.0 5.6 27 5.5 0.0 3.2 2 1 1 3 3 3 0 5'-3' exonuclease, C-terminal SAM fold Exonuc_VII_L PF02601.15 EMC89459.1 - 6.3 6.3 9.4 49 3.3 9.4 2.1 1 1 0 1 1 1 0 Exonuclease VII, large subunit Guanylate_kin PF00625.21 EMC89461.1 - 1.1e-26 93.6 0.0 2.2e-26 92.7 0.0 1.5 1 0 0 1 1 1 1 Guanylate kinase LRR_4 PF12799.7 EMC89461.1 - 4.5e-22 77.8 40.8 1.1e-06 28.8 2.0 6.3 4 2 1 6 6 6 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC89461.1 - 1.2e-18 67.3 10.5 2.9e-16 59.5 2.9 3.0 1 1 1 3 3 3 2 Leucine-rich repeat LRR_8 PF13855.6 EMC89461.1 - 6.5e-14 51.4 39.0 0.00061 19.5 5.5 5.8 2 1 2 5 5 5 5 Leucine rich repeat LRR_6 PF13516.6 EMC89461.1 - 3e-06 26.9 36.5 0.41 10.8 0.3 9.1 9 1 1 10 10 10 5 Leucine Rich repeat LRR_1 PF00560.33 EMC89461.1 - 0.84 10.4 28.4 23 6.0 0.1 8.7 7 3 0 7 7 7 0 Leucine Rich Repeat UAA PF08449.11 EMC89463.1 - 4e-60 203.6 7.5 4.4e-60 203.4 7.5 1.0 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.16 EMC89463.1 - 5e-06 26.1 1.7 5.8e-06 25.9 1.7 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EMC89463.1 - 0.0044 17.2 12.3 0.012 15.8 12.3 1.7 1 1 0 1 1 1 1 EamA-like transporter family Kunitz_BPTI PF00014.23 EMC89464.1 - 3e-18 65.8 5.5 3.3e-18 65.7 5.5 1.0 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Tubulin PF00091.25 EMC89465.1 - 7.9e-68 228.5 0.0 1.1e-67 228.1 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EMC89465.1 - 4.9e-51 172.2 0.0 7.7e-51 171.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EMC89465.1 - 0.0046 16.7 0.0 0.0089 15.7 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain RhoGEF PF00621.20 EMC89466.1 - 1.7e-36 126.2 0.0 3.1e-36 125.3 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.5 EMC89466.1 - 1.4e-09 38.0 0.1 1.1e-08 35.0 0.0 2.5 2 1 0 2 2 2 1 Pleckstrin homology domain PH_5 PF15405.6 EMC89466.1 - 6.4e-08 32.8 0.2 4.4e-07 30.1 0.2 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EMC89466.1 - 1.6e-07 31.8 0.0 3.2e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 EMC89466.1 - 0.0093 16.0 0.0 0.024 14.6 0.0 1.6 1 0 0 1 1 1 1 PH domain PT PF04886.12 EMC89467.1 - 8.5e-08 31.6 8.0 0.0012 18.3 2.0 4.7 4 1 0 4 4 4 3 PT repeat EF-hand_1 PF00036.32 EMC89468.1 - 1.7e-38 127.3 10.4 8.5e-10 37.5 0.0 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EMC89468.1 - 1e-34 118.8 3.9 1.2e-17 64.1 1.9 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EMC89468.1 - 2.1e-33 113.9 10.4 1.9e-15 56.4 0.9 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 EMC89468.1 - 1.7e-30 102.3 5.6 1.1e-09 37.4 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EMC89468.1 - 1.8e-24 84.1 6.2 2.8e-06 26.6 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 EMC89468.1 - 9.4e-16 57.9 0.2 3.7e-09 36.8 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EMC89468.1 - 1.3e-07 31.5 0.4 0.0026 17.7 0.2 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EMC89468.1 - 7.6e-06 26.2 0.2 0.0035 17.7 0.2 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 EMC89468.1 - 2.4e-05 25.1 0.1 0.00083 20.2 0.1 2.1 1 1 1 2 2 2 1 EF-hand domain EFhand_Ca_insen PF08726.10 EMC89468.1 - 3.7e-05 23.7 0.3 9.6e-05 22.4 0.3 1.8 1 1 0 1 1 1 1 Ca2+ insensitive EF hand UPF0154 PF03672.13 EMC89468.1 - 0.0001 22.2 0.0 0.33 11.0 0.0 2.8 2 1 0 2 2 2 2 Uncharacterised protein family (UPF0154) Caleosin PF05042.13 EMC89468.1 - 0.0013 18.7 0.1 0.075 13.0 0.1 2.8 1 1 1 2 2 2 1 Caleosin related protein Dockerin_1 PF00404.18 EMC89468.1 - 0.0013 18.9 3.1 0.51 10.6 3.3 2.8 1 1 1 2 2 2 1 Dockerin type I domain DUF3349 PF11829.8 EMC89468.1 - 0.0018 19.0 0.2 6 7.7 0.0 2.9 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) DUF5580 PF17743.1 EMC89468.1 - 0.0027 16.3 0.0 0.0027 16.3 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) TerB PF05099.13 EMC89468.1 - 0.0027 17.7 0.9 1.9 8.5 0.0 2.2 1 1 1 2 2 2 2 Tellurite resistance protein TerB SurA_N_3 PF13624.6 EMC89468.1 - 0.0061 16.4 0.3 0.01 15.6 0.3 1.5 1 1 0 1 1 1 1 SurA N-terminal domain Toprim_2 PF13155.6 EMC89468.1 - 0.011 16.2 0.3 2.4 8.7 0.2 2.2 1 1 0 2 2 2 0 Toprim-like FGAR-AT_linker PF18072.1 EMC89468.1 - 0.065 13.8 0.4 3.7 8.2 0.0 2.6 2 2 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain SurA_N_2 PF13623.6 EMC89468.1 - 0.07 13.0 0.6 0.29 11.0 0.2 1.9 1 1 1 2 2 2 0 SurA N-terminal domain RNA_pol_Rpb4 PF03874.16 EMC89468.1 - 0.089 13.1 1.5 0.43 10.9 0.2 2.3 3 0 0 3 3 2 0 RNA polymerase Rpb4 Ank_4 PF13637.6 EMC89469.1 - 1.4e-42 143.5 8.6 8.9e-11 42.1 1.2 4.4 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 EMC89469.1 - 6.1e-40 134.0 10.2 8.6e-07 29.1 0.1 6.6 7 0 0 7 7 7 6 Ankyrin repeat Ank_2 PF12796.7 EMC89469.1 - 4.8e-37 126.4 8.0 5e-17 62.3 2.9 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC89469.1 - 1.6e-30 101.8 3.2 0.00013 22.1 0.0 6.6 6 0 0 6 6 6 6 Ankyrin repeat Ank_5 PF13857.6 EMC89469.1 - 4.3e-26 90.6 4.9 9e-06 25.9 0.0 5.2 1 1 4 5 5 5 5 Ankyrin repeats (many copies) SOCS_box PF07525.16 EMC89469.1 - 6.3e-10 39.2 0.9 1.1e-09 38.5 0.9 1.4 1 0 0 1 1 1 1 SOCS box Prok-RING_1 PF14446.6 EMC89469.1 - 1.2 9.2 3.9 12 5.9 0.3 3.2 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 DUF3699 PF12480.8 EMC89470.1 - 0.0055 16.8 0.0 0.0091 16.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3699) DUF3715 PF12509.8 EMC89471.1 - 0.0072 16.3 0.1 0.013 15.5 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3715) GDI PF00996.18 EMC89472.1 - 1.3e-226 752.2 0.2 1.5e-226 752.0 0.2 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor Myc_N PF01056.18 EMC89472.1 - 0.036 14.0 0.0 0.098 12.5 0.0 1.7 2 0 0 2 2 2 0 Myc amino-terminal region SH3_14 PF18343.1 EMC89472.1 - 0.042 14.0 3.2 3.4 7.8 0.3 3.2 2 1 0 3 3 3 0 Dda helicase SH3 domain Amino_oxidase PF01593.24 EMC89472.1 - 0.061 12.6 0.0 0.081 12.2 0.0 1.1 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase AAA_19 PF13245.6 EMC89473.1 - 1.8e-15 57.5 0.0 3.9e-15 56.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 EMC89473.1 - 3.9e-15 56.2 0.7 1.3e-08 34.8 0.0 3.0 2 1 0 2 2 2 2 UvrD/REP helicase N-terminal domain AAA_30 PF13604.6 EMC89473.1 - 7.5e-09 35.6 0.0 0.0002 21.1 0.0 2.3 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 EMC89473.1 - 1.4e-06 28.3 0.0 0.0065 16.2 0.0 2.4 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 EMC89473.1 - 4.2e-06 26.4 0.1 0.073 12.5 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_11 PF13086.6 EMC89473.1 - 0.00052 19.9 0.3 0.73 9.6 0.1 2.3 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EMC89473.1 - 0.0016 18.7 0.0 0.039 14.2 0.0 2.6 2 1 1 3 3 3 1 AAA domain TGS PF02824.21 EMC89473.1 - 0.082 13.0 0.0 11 6.2 0.0 2.5 2 0 0 2 2 2 0 TGS domain ResIII PF04851.15 EMC89473.1 - 0.14 12.1 2.0 0.62 10.0 2.0 2.0 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Sushi PF00084.20 EMC89474.1 - 5.7e-06 26.8 0.1 1.7e-05 25.3 0.1 1.9 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) PT PF04886.12 EMC89475.1 - 6e-10 38.5 0.0 0.04 13.5 0.0 4.1 2 1 0 2 2 2 2 PT repeat Adaptin_N PF01602.20 EMC89476.1 - 1.4e-53 182.2 1.9 1.6e-53 182.1 1.9 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EMC89476.1 - 4e-05 23.7 1.2 0.00047 20.2 0.3 2.2 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 PuR_N PF09182.10 EMC89476.1 - 0.14 12.1 0.0 0.43 10.6 0.0 1.9 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal Abhydrolase_1 PF00561.20 EMC89477.1 - 2.8e-08 33.7 0.0 1.2e-07 31.6 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMC89477.1 - 3.8e-07 30.9 0.0 4.5e-07 30.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMC89477.1 - 3.8e-05 23.1 0.0 0.00019 20.8 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DUF1057 PF06342.12 EMC89477.1 - 0.0055 15.8 0.0 0.0077 15.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Death PF00531.22 EMC89477.1 - 0.16 12.1 0.0 0.42 10.8 0.0 1.6 1 0 0 1 1 1 0 Death domain Rhodanese PF00581.20 EMC89478.1 - 6.1e-13 49.2 0.0 3.1e-12 47.0 0.0 2.1 3 0 0 3 3 3 1 Rhodanese-like domain Peptidase_M14 PF00246.24 EMC89479.1 - 1.5e-91 307.2 0.0 1.8e-91 307.0 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 EMC89479.1 - 1.1e-21 76.9 0.1 2.6e-21 75.8 0.1 1.7 1 0 0 1 1 1 1 Carboxypeptidase activation peptide Peptidase_M14 PF00246.24 EMC89480.1 - 8e-90 301.5 0.0 1.1e-89 301.2 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 EMC89480.1 - 7.3e-23 80.8 0.3 1.6e-22 79.7 0.1 1.7 2 0 0 2 2 2 1 Carboxypeptidase activation peptide DUF4636 PF15468.6 EMC89481.1 - 2.6e-05 24.1 2.3 0.00033 20.4 2.3 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4636) CytochromB561_N PF09786.9 EMC89482.1 - 1.8e-150 502.7 3.6 2.2e-150 502.4 3.6 1.0 1 0 0 1 1 1 1 Cytochrome B561, N terminal NPCC PF08058.11 EMC89482.1 - 0.01 15.9 0.0 0.024 14.7 0.0 1.6 1 0 0 1 1 1 0 Nuclear pore complex component Kelch_1 PF01344.25 EMC89483.1 - 1.5e-41 139.7 9.7 7.6e-10 38.2 0.1 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 EMC89483.1 - 1.2e-39 133.3 4.9 4.5e-07 29.9 0.0 6.1 5 1 1 6 6 6 5 Kelch motif Kelch_4 PF13418.6 EMC89483.1 - 3.2e-36 123.1 11.8 1.9e-10 40.6 0.0 5.8 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.6 EMC89483.1 - 1.9e-32 110.9 12.9 2.1e-07 31.1 0.0 7.0 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC89483.1 - 2.4e-32 110.4 7.4 1.5e-05 24.9 0.1 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_2 PF07646.15 EMC89483.1 - 3.6e-27 93.3 12.3 7.5e-06 25.7 0.1 6.8 5 2 1 6 6 6 6 Kelch motif Rsm1 PF08600.10 EMC89484.1 - 4.4e-13 49.2 0.1 4.9e-06 26.6 0.0 2.4 2 0 0 2 2 2 2 Rsm1-like UQ_con PF00179.26 EMC89485.1 - 1.5e-37 128.3 0.0 1.9e-37 128.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Uteroglobin PF01099.17 EMC89485.1 - 0.14 12.5 1.2 0.27 11.6 0.9 1.6 1 1 0 2 2 2 0 Uteroglobin family Nrf1_DNA-bind PF10491.9 EMC89486.1 - 2.5e-116 386.8 0.1 3.7e-116 386.2 0.1 1.3 1 0 0 1 1 1 1 NLS-binding and DNA-binding and dimerisation domains of Nrf1 Nrf1_activ_bdg PF10492.9 EMC89486.1 - 0.00088 19.9 6.7 0.00088 19.9 6.7 5.7 3 2 1 4 4 4 1 Nrf1 activator activation site binding domain DUF3459 PF11941.8 EMC89486.1 - 0.096 13.0 0.6 0.37 11.2 0.6 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3459) Peptidase_M23 PF01551.22 EMC89486.1 - 0.46 10.7 3.4 0.87 9.8 1.0 2.4 1 1 1 2 2 2 0 Peptidase family M23 AdoHcyase PF05221.17 EMC89487.1 - 3.1e-103 345.0 0.0 1.1e-65 221.7 0.2 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 EMC89487.1 - 1.4e-55 187.7 0.1 2.4e-55 187.0 0.1 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EMC89487.1 - 4.1e-05 23.0 0.4 7.5e-05 22.2 0.0 1.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EMC89487.1 - 0.00049 19.7 0.0 0.0011 18.6 0.0 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 EMC89487.1 - 0.012 15.9 0.2 0.025 14.8 0.2 1.6 1 0 0 1 1 1 0 TrkA-N domain Shikimate_DH PF01488.20 EMC89487.1 - 0.016 15.3 0.1 0.049 13.7 0.1 1.8 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase THF_DHG_CYH_C PF02882.19 EMC89487.1 - 0.097 12.0 0.2 0.33 10.2 0.2 1.8 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain SR-25 PF10500.9 EMC89487.1 - 0.25 10.9 8.6 0.34 10.5 8.6 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ycf34 PF10718.9 EMC89488.1 - 0.00044 20.9 8.6 18 6.1 0.1 5.8 2 1 3 5 5 5 5 Hypothetical chloroplast protein Ycf34 DUF1242 PF06842.12 EMC89490.1 - 7.6 6.4 9.3 8.7 6.2 0.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1242) Tetraspanin PF00335.20 EMC89491.1 - 7.3e-88 294.1 17.0 8.3e-88 293.9 17.0 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF5464 PF17552.2 EMC89491.1 - 0.34 11.2 5.9 0.14 12.4 2.6 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5464) Xpo1 PF08389.12 EMC89492.1 - 5e-25 88.3 0.4 8.3e-25 87.6 0.4 1.4 1 0 0 1 1 1 1 Exportin 1-like protein IFRD PF05004.13 EMC89493.1 - 0.0083 15.3 0.0 0.098 11.7 0.0 2.2 2 0 0 2 2 2 1 Interferon-related developmental regulator (IFRD) Xpo1 PF08389.12 EMC89493.1 - 0.026 14.6 1.0 11 6.0 0.0 3.4 2 1 1 3 3 3 0 Exportin 1-like protein Herpes_UL49_2 PF04823.12 EMC89494.1 - 0.068 13.3 3.0 2.6 8.2 0.3 2.2 2 0 0 2 2 2 0 Herpesvirus UL49 tegument protein EF-hand_1 PF00036.32 EMC89495.1 - 4.6e-23 79.0 18.5 4.6e-05 22.7 0.6 7.3 7 0 0 7 7 7 6 EF hand EF-hand_6 PF13405.6 EMC89495.1 - 7.4e-19 66.0 15.7 0.0023 17.7 0.0 7.2 7 0 0 7 7 7 6 EF-hand domain EF-hand_7 PF13499.6 EMC89495.1 - 3.4e-18 65.8 22.2 1.1e-05 25.8 2.8 4.3 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 EMC89495.1 - 2.5e-16 58.3 29.9 0.00012 21.4 0.9 7.1 7 1 0 7 7 7 5 EF hand EF-hand_8 PF13833.6 EMC89495.1 - 3.1e-10 39.8 11.2 0.00082 19.2 0.0 5.4 5 1 0 5 5 5 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EMC89495.1 - 0.026 14.8 11.3 0.62 10.4 0.5 3.7 3 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 EMC89495.1 - 0.19 11.6 1.4 1.7 8.6 0.3 2.8 2 1 0 2 2 2 0 EF hand 7tm_1 PF00001.21 EMC89496.1 - 9.1e-41 139.9 13.0 1.1e-40 139.7 13.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC89496.1 - 4.4e-08 33.1 15.4 7.2e-08 32.4 15.2 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 EMC89496.1 - 1e-07 31.6 15.6 2.4e-07 30.4 15.6 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 EMC89496.1 - 5.3e-06 26.4 9.2 0.00082 19.2 2.2 2.1 2 0 0 2 2 2 2 Olfactory receptor zf-LITAF-like PF10601.9 EMC89496.1 - 0.18 12.1 4.5 4.8 7.5 0.2 3.4 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain DUF1673 PF07895.11 EMC89496.1 - 0.23 11.1 8.6 0.58 9.8 1.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1673) BHD_1 PF10403.9 EMC89503.1 - 0.031 14.1 0.6 4.7 7.1 0.0 3.7 4 0 0 4 4 4 0 Rad4 beta-hairpin domain 1 GDE_C PF06202.14 EMC89503.1 - 0.22 10.4 0.1 0.3 10.0 0.1 1.1 1 0 0 1 1 1 0 Amylo-alpha-1,6-glucosidase RRM_1 PF00076.22 EMC89507.1 - 2.3e-37 126.6 0.0 7e-16 57.8 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CDC45 PF02724.14 EMC89507.1 - 1.8e-06 26.6 7.6 1.9e-06 26.5 7.6 1.1 1 0 0 1 1 1 1 CDC45-like protein BUD22 PF09073.10 EMC89507.1 - 2.8e-06 27.0 14.3 3.8e-06 26.5 14.3 1.2 1 0 0 1 1 1 1 BUD22 SDA1 PF05285.12 EMC89507.1 - 8.9e-05 22.1 21.4 0.00013 21.6 21.4 1.2 1 0 0 1 1 1 1 SDA1 Na_trans_assoc PF06512.13 EMC89507.1 - 0.00097 19.5 12.7 0.0015 18.9 12.7 1.3 1 0 0 1 1 1 1 Sodium ion transport-associated SpoIIIAH PF12685.7 EMC89507.1 - 0.0012 18.7 3.8 0.0017 18.2 3.8 1.2 1 0 0 1 1 1 1 SpoIIIAH-like protein NPR3 PF03666.13 EMC89507.1 - 0.0058 15.5 3.7 0.0076 15.1 3.7 1.1 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 Nop14 PF04147.12 EMC89507.1 - 0.0099 14.1 29.2 0.014 13.7 29.2 1.1 1 0 0 1 1 1 1 Nop14-like family SAPS PF04499.15 EMC89507.1 - 0.01 14.6 2.0 0.013 14.3 2.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Zip PF02535.22 EMC89507.1 - 0.05 12.8 3.2 0.058 12.6 3.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter RNA_polI_A34 PF08208.11 EMC89507.1 - 0.066 13.3 17.7 0.16 12.1 17.7 1.6 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RNA_pol_Rpc4 PF05132.14 EMC89507.1 - 0.078 13.4 5.8 0.21 12.0 5.8 1.7 1 0 0 1 1 1 0 RNA polymerase III RPC4 Mpp10 PF04006.12 EMC89507.1 - 0.12 10.8 30.7 0.16 10.4 30.7 1.1 1 0 0 1 1 1 0 Mpp10 protein Vfa1 PF08432.10 EMC89507.1 - 0.21 11.9 14.3 0.34 11.2 14.3 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SpoIIP PF07454.11 EMC89507.1 - 0.25 10.8 8.8 0.37 10.2 8.8 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DNA_pol_phi PF04931.13 EMC89507.1 - 0.35 8.9 37.1 0.51 8.4 37.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi Cwf_Cwc_15 PF04889.12 EMC89507.1 - 1 9.0 24.0 2 8.1 24.0 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2828 PF11443.8 EMC89507.1 - 1.5 6.9 4.2 2 6.4 4.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF913 PF06025.12 EMC89507.1 - 1.8 7.4 8.1 3.2 6.6 8.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2151 PF10221.9 EMC89507.1 - 3.5 6.1 9.2 4.6 5.7 9.2 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Presenilin PF01080.17 EMC89507.1 - 4.8 5.8 12.7 6.8 5.3 12.7 1.1 1 0 0 1 1 1 0 Presenilin DUF4746 PF15928.5 EMC89507.1 - 5.6 6.3 26.2 10 5.5 26.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PHM7_cyt PF14703.6 EMC89507.1 - 8.8 6.5 8.6 1.4e+02 2.6 0.0 3.7 3 1 1 4 4 2 0 Cytosolic domain of 10TM putative phosphate transporter PTPRCAP PF15713.5 EMC89507.1 - 8.8 6.6 30.8 22 5.3 30.8 1.6 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated SNase PF00565.17 EMC89509.1 - 2.6e-55 185.5 0.1 6.3e-16 58.8 0.0 4.7 4 1 0 4 4 4 4 Staphylococcal nuclease homologue TUDOR PF00567.24 EMC89509.1 - 1.6e-27 95.9 0.0 3.6e-27 94.8 0.0 1.6 1 0 0 1 1 1 1 Tudor domain Agenet PF05641.12 EMC89509.1 - 0.02 15.3 0.1 0.65 10.5 0.0 3.4 3 0 0 3 3 3 0 Agenet domain Tecti-min-caps PF09300.10 EMC89509.1 - 0.16 12.0 0.0 0.72 9.9 0.0 2.0 2 0 0 2 2 2 0 Tectiviridae, minor capsid PAX PF00292.18 EMC89510.1 - 1.1e-50 170.7 0.1 1.6e-50 170.2 0.1 1.2 1 0 0 1 1 1 1 'Paired box' domain Homeodomain PF00046.29 EMC89510.1 - 7.1e-20 70.6 2.8 1.6e-19 69.5 2.8 1.6 1 0 0 1 1 1 1 Homeodomain HTH_32 PF13565.6 EMC89510.1 - 0.00013 22.5 2.5 0.0012 19.5 0.0 2.9 3 1 0 3 3 3 1 Homeodomain-like domain HTH_23 PF13384.6 EMC89510.1 - 0.00051 19.8 1.2 0.00074 19.2 0.0 1.9 2 0 0 2 2 2 1 Homeodomain-like domain Homeobox_KN PF05920.11 EMC89510.1 - 0.01 15.7 0.1 0.028 14.3 0.1 1.7 1 0 0 1 1 1 0 Homeobox KN domain HTH_28 PF13518.6 EMC89510.1 - 0.02 15.0 1.5 0.057 13.6 0.1 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain Fe_dep_repress PF01325.19 EMC89510.1 - 0.12 12.6 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain PDDEXK_7 PF04411.12 EMC89510.1 - 0.12 12.3 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily Arf PF00025.21 EMC89511.1 - 3.8e-72 241.4 0.2 4.2e-72 241.2 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EMC89511.1 - 2.4e-14 53.6 0.1 3.3e-14 53.1 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EMC89511.1 - 4.7e-13 49.0 0.0 5.6e-13 48.7 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EMC89511.1 - 6.6e-13 48.6 0.0 7e-13 48.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EMC89511.1 - 2.2e-10 40.3 0.0 2.5e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EMC89511.1 - 3.9e-10 39.4 0.6 3.1e-09 36.4 0.3 2.1 1 1 1 2 2 2 1 G-protein alpha subunit MMR_HSR1 PF01926.23 EMC89511.1 - 2.5e-05 24.3 0.0 3.7e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GRIP PF01465.20 EMC89512.1 - 2.4e-16 59.4 0.0 6.1e-16 58.0 0.0 1.8 1 0 0 1 1 1 1 GRIP domain SPA PF08616.10 EMC89515.1 - 6.4e-08 32.6 0.0 1.8e-07 31.1 0.0 1.7 2 0 0 2 2 2 1 Stabilization of polarity axis DENN PF02141.21 EMC89515.1 - 9.9e-05 22.4 0.7 0.0003 20.8 0.7 1.9 1 1 0 1 1 1 1 DENN (AEX-3) domain Avl9 PF09794.9 EMC89515.1 - 0.00054 18.8 0.0 0.00098 17.9 0.0 1.4 1 0 0 1 1 1 1 Transport protein Avl9 RAM PF15320.6 EMC89515.1 - 0.3 11.7 0.1 0.3 11.7 0.1 1.8 2 0 0 2 2 2 0 mRNA cap methylation, RNMT-activating mini protein SAPS PF04499.15 EMC89516.1 - 5e-77 259.7 19.8 1.6e-60 205.3 1.2 4.0 4 0 0 4 4 4 2 SIT4 phosphatase-associated protein Arm PF00514.23 EMC89516.1 - 0.0025 17.8 0.7 2.2 8.5 0.0 3.7 3 1 1 4 4 4 2 Armadillo/beta-catenin-like repeat E3_UbLigase_RBR PF18091.1 EMC89516.1 - 1.5 9.0 4.6 0.66 10.1 0.1 2.8 3 0 0 3 3 3 0 E3 Ubiquitin Ligase RBR C-terminal domain Utp14 PF04615.13 EMC89516.1 - 3.7 6.0 15.7 0.17 10.4 10.2 1.4 2 0 0 2 2 2 0 Utp14 protein Myotub-related PF06602.14 EMC89517.1 - 2.5e-42 145.1 4.2 2.7e-42 145.0 4.2 1.0 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DUF236 PF03057.14 EMC89517.1 - 0.17 11.9 0.1 1.6 8.8 0.0 2.0 2 0 0 2 2 2 0 DUF236 repeat Myotub-related PF06602.14 EMC89518.1 - 3.6e-20 72.2 0.0 4.1e-20 72.0 0.0 1.0 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain CNDH2_N PF06278.11 EMC89519.1 - 1.9e-42 144.0 0.0 2.8e-42 143.5 0.0 1.2 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal CNDH2_C PF16858.5 EMC89519.1 - 1.8e-21 77.3 0.1 3e-21 76.6 0.1 1.4 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term CNDH2_M PF16869.5 EMC89519.1 - 1.6e-13 51.6 0.1 3.9e-13 50.3 0.1 1.7 1 0 0 1 1 1 1 PF16858 Collagen PF01391.18 EMC89521.1 - 2.1e-06 27.4 61.7 0.34 10.7 13.6 4.4 1 1 1 2 2 2 1 Collagen triple helix repeat (20 copies) Drf_FH1 PF06346.12 EMC89522.1 - 0.91 9.2 32.1 7 6.4 15.5 2.4 1 1 1 2 2 2 0 Formin Homology Region 1 Choline_kinase PF01633.20 EMC89523.1 - 3.1e-54 183.8 0.2 3.3e-53 180.4 0.1 2.1 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 EMC89523.1 - 7.8e-10 39.1 0.0 1.2e-09 38.5 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EMC89523.1 - 2e-05 24.1 0.1 3.4e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase Pkinase_fungal PF17667.1 EMC89523.1 - 0.0082 15.0 0.0 0.012 14.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase SH3_9 PF14604.6 EMC89524.1 - 1.4e-13 50.4 0.2 4.2e-13 48.9 0.2 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC89524.1 - 6.2e-07 28.9 0.0 1.5e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain Ank_4 PF13637.6 EMC89526.1 - 2.9e-12 46.9 3.0 2.4e-06 28.0 0.7 3.7 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC89526.1 - 7.8e-11 42.4 0.7 2.2e-08 34.6 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC89526.1 - 4.6e-09 36.4 0.9 5.6e-05 23.4 0.3 3.2 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EMC89526.1 - 2.9e-08 33.8 4.8 0.22 12.1 0.1 4.9 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 EMC89526.1 - 1.5e-06 28.1 4.3 0.32 11.7 0.0 5.0 5 0 0 5 5 5 2 Ankyrin repeat FERM_f0 PF16511.5 EMC89526.1 - 0.0017 18.7 0.0 0.0056 17.0 0.0 1.8 2 0 0 2 2 2 1 N-terminal or F0 domain of Talin-head FERM UPF0180 PF03698.13 EMC89528.1 - 9.3e-40 134.7 0.0 9.3 6.5 0.0 22.4 1 1 20 21 21 21 21 Uncharacterised protein family (UPF0180) YrzK PF17449.2 EMC89528.1 - 0.00073 19.8 52.5 3.4e+02 1.6 0.0 19.5 22 0 0 22 22 22 0 Uncharacterized YrzK-like DUF5544 PF17698.1 EMC89528.1 - 2.9 8.0 28.6 3.6e+02 1.3 0.2 11.6 1 1 20 21 21 21 0 Family of unknown function (DUF5544) Trypsin PF00089.26 EMC89529.1 - 2.2e-70 236.9 3.9 2.5e-70 236.7 3.9 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EMC89529.1 - 6.2e-06 27.2 0.1 1.1e-05 26.4 0.1 1.4 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 EMC89529.1 - 0.00012 22.5 0.8 0.00019 21.8 0.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) DUF316 PF03761.15 EMC89529.1 - 0.0029 17.2 2.2 0.74 9.3 0.0 2.6 1 1 0 2 2 2 2 Chymotrypsin family Peptidase-S1 Sulfatase_C PF14707.6 EMC89530.1 - 2.7e-27 96.0 0.1 2.9e-27 95.9 0.1 1.0 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Sulfatase PF00884.23 EMC89531.1 - 1.5e-12 47.6 0.0 1.6e-12 47.4 0.0 1.0 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EMC89531.1 - 1.2e-06 28.4 0.0 1.2e-06 28.4 0.0 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF1501 PF07394.12 EMC89531.1 - 0.0017 17.5 0.0 0.0018 17.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1501) Trypsin PF00089.26 EMC89532.1 - 1.7e-68 230.7 4.7 1.9e-68 230.6 4.7 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EMC89532.1 - 2e-06 28.8 0.2 3e-06 28.2 0.2 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 EMC89532.1 - 3.5e-05 24.2 0.9 5.3e-05 23.6 0.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) DUF316 PF03761.15 EMC89532.1 - 0.00057 19.5 0.2 0.56 9.7 0.0 2.6 2 1 0 2 2 2 2 Chymotrypsin family Peptidase-S1 Ras PF00071.22 EMC89533.1 - 1.1e-28 99.9 0.0 1.3e-28 99.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC89533.1 - 2.6e-20 72.8 0.0 4.2e-20 72.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC89533.1 - 5.2e-07 29.3 0.0 6.9e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC89533.1 - 8.1e-06 25.5 0.0 2.9e-05 23.7 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EMC89533.1 - 0.0012 18.3 0.0 0.0018 17.7 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 EMC89533.1 - 0.038 13.8 0.1 0.046 13.5 0.1 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein MMR_HSR1_Xtn PF16897.5 EMC89533.1 - 0.087 12.9 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain NDK PF00334.19 EMC89534.1 - 9.3e-18 64.5 0.0 1.2e-17 64.1 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase DUF1281_C PF18406.1 EMC89534.1 - 0.017 14.8 0.0 0.022 14.4 0.0 1.2 1 0 0 1 1 1 0 Ferredoxin-like domain in Api92-like protein 7tm_4 PF13853.6 EMC89536.1 - 1.8e-51 175.6 7.2 2e-51 175.4 7.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC89536.1 - 1.9e-28 99.5 12.1 2.5e-28 99.1 12.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC89536.1 - 0.00039 19.9 2.6 0.00058 19.3 1.4 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC89536.1 - 0.0041 16.8 1.8 0.0041 16.8 1.8 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 EMC89536.1 - 0.037 13.4 4.7 0.053 12.9 3.9 1.6 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srv HS1_rep PF02218.15 EMC89537.1 - 2e-59 197.6 40.2 5.5e-17 61.8 6.3 5.5 6 0 0 6 6 6 4 Repeat in HS1/Cortactin SH3_9 PF14604.6 EMC89537.1 - 2.6e-17 62.4 0.2 7.4e-17 60.9 0.2 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC89537.1 - 7e-16 57.6 0.2 1.7e-15 56.4 0.2 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMC89537.1 - 2.5e-08 33.5 0.1 9.7e-08 31.6 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain TMEM210 PF15195.6 EMC89537.1 - 0.016 15.6 0.2 1e+02 3.3 0.0 4.0 2 2 2 4 4 4 0 TMEM210 family Collagen PF01391.18 EMC89538.1 - 5.1e-07 29.4 11.9 0.0033 17.1 2.4 3.1 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Bactofilin PF04519.13 EMC89538.1 - 0.00019 21.6 15.6 0.017 15.4 11.0 2.3 1 1 1 2 2 2 2 Polymer-forming cytoskeletal CRAM_rpt PF07016.11 EMC89538.1 - 0.0025 17.5 5.7 2.2 8.2 0.0 4.7 3 2 1 4 4 4 3 Cysteine-rich acidic integral membrane protein precursor Chorion_1 PF01723.16 EMC89538.1 - 0.0035 17.3 5.2 1.2 9.1 0.4 2.6 1 1 2 3 3 3 3 Chorion protein DUF3617 PF12276.8 EMC89538.1 - 0.25 11.7 5.2 1 9.7 5.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3617) EF-hand_1 PF00036.32 EMC89539.1 - 6e-24 81.8 13.5 2.6e-07 29.7 0.2 5.2 4 1 1 5 5 5 4 EF hand EF-hand_6 PF13405.6 EMC89539.1 - 1.2e-22 77.8 4.0 3.3e-06 26.6 0.0 4.5 4 1 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 EMC89539.1 - 2.2e-22 79.3 5.0 1.6e-15 57.3 0.1 3.0 2 2 1 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 EMC89539.1 - 6.7e-18 64.3 4.7 1.2e-09 37.8 0.1 3.1 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EMC89539.1 - 9.4e-17 59.7 11.5 6.5e-06 25.4 0.4 4.8 5 1 0 5 5 5 3 EF hand SPARC_Ca_bdg PF10591.9 EMC89539.1 - 1.9e-07 31.4 0.2 0.00061 20.1 0.0 2.7 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 EMC89539.1 - 9.9e-06 25.7 1.8 0.0095 16.1 1.0 3.1 2 1 0 2 2 2 2 Dockerin type I domain EF-hand_4 PF12763.7 EMC89539.1 - 1.6e-05 24.8 2.3 0.62 10.1 0.1 3.3 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand DUF4891 PF16232.5 EMC89539.1 - 0.11 13.0 0.0 5.8 7.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4891) EF-hand_9 PF14658.6 EMC89539.1 - 0.16 12.3 0.6 0.94 9.9 0.0 2.4 2 1 1 3 3 3 0 EF-hand domain Acetyltransf_1 PF00583.25 EMC89541.1 - 6.2e-12 45.8 0.0 9.5e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMC89541.1 - 2.2e-09 37.3 0.0 3.2e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMC89541.1 - 1.9e-08 34.1 0.0 2.9e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 EMC89541.1 - 3e-08 34.0 0.0 5.5e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EMC89541.1 - 0.0028 17.7 0.0 0.0047 17.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PACT_coil_coil PF10495.9 EMC89542.1 - 2.6e-24 85.6 0.2 6.4e-24 84.4 0.0 1.6 2 0 0 2 2 2 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein Alkyl_sulf_dimr PF14863.6 EMC89543.1 - 0.15 12.5 3.0 0.24 11.8 3.0 1.3 1 0 0 1 1 1 0 Alkyl sulfatase dimerisation DUF3138 PF11336.8 EMC89543.1 - 0.22 10.1 0.9 0.23 10.0 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DUF4587 PF15248.6 EMC89544.1 - 2.2e-32 111.6 11.4 2.2e-32 111.6 11.4 2.6 2 1 1 3 3 3 1 Domain of unknown function (DUF4587) APH PF01636.23 EMC89544.1 - 4.9 7.0 10.5 4.2 7.2 6.4 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family FAD_binding_3 PF01494.19 EMC89545.1 - 1.7e-20 73.6 0.0 3.5e-20 72.6 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EMC89545.1 - 7.9e-06 25.7 0.1 8.4e-05 22.3 0.7 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMC89545.1 - 5.3e-05 23.4 0.3 0.0002 21.5 0.3 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SE PF08491.10 EMC89545.1 - 0.00021 20.4 0.1 0.11 11.5 0.0 2.4 2 1 0 2 2 2 2 Squalene epoxidase 3HCDH_N PF02737.18 EMC89545.1 - 0.0013 18.6 0.2 0.0021 18.0 0.2 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 EMC89545.1 - 0.029 13.6 0.1 0.05 12.8 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMC89545.1 - 0.049 14.2 0.5 0.097 13.2 0.5 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 EMC89545.1 - 0.06 13.8 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Integrin_beta PF00362.18 EMC89546.1 - 2e-116 388.0 0.0 2.9e-116 387.4 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.11 EMC89546.1 - 1.1e-20 73.0 1.0 2.5e-20 71.9 1.0 1.6 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.12 EMC89546.1 - 4.9e-18 65.4 11.9 4.9e-18 65.4 11.9 4.6 4 1 0 4 4 4 1 Integrin beta tail domain PSI_integrin PF17205.3 EMC89546.1 - 1.5e-14 53.5 6.5 1.5e-14 53.5 6.5 4.5 5 2 1 6 6 6 1 Integrin plexin domain I-EGF_1 PF18372.1 EMC89546.1 - 4.7e-09 36.2 11.6 4.7e-09 36.2 11.6 6.0 6 1 0 6 6 6 2 Integrin beta epidermal growth factor like domain 1 EGF_2 PF07974.13 EMC89546.1 - 0.0063 16.9 30.6 0.0088 16.4 9.8 7.1 6 1 1 7 7 7 3 EGF-like domain SLX9 PF15341.6 EMC89547.1 - 1.8e-18 67.2 1.4 2.1e-18 67.0 1.4 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 Keratin PF02422.16 EMC89549.1 - 6.4e-33 112.3 15.1 7.8e-33 112.1 15.1 1.1 1 0 0 1 1 1 1 Keratin DUF3432 PF11914.8 EMC89549.1 - 0.21 11.8 9.7 0.5 10.6 9.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3432) Keratin PF02422.16 EMC89550.1 - 2.7e-31 107.1 14.6 3.2e-31 106.9 14.6 1.1 1 0 0 1 1 1 1 Keratin DUF3432 PF11914.8 EMC89550.1 - 2.3 8.5 13.2 11 6.4 12.8 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3432) BAR PF03114.18 EMC89552.1 - 7.5e-75 251.7 8.3 8.8e-75 251.4 8.3 1.0 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 EMC89552.1 - 3.2e-15 55.5 0.3 1.7e-14 53.2 0.1 2.2 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EMC89552.1 - 1.2e-13 50.5 0.0 2.2e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EMC89552.1 - 1.5e-13 50.4 0.1 2.9e-13 49.4 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain BAR_2 PF10455.9 EMC89552.1 - 1.5e-08 34.2 4.0 8.2e-08 31.7 2.8 2.0 2 0 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3 PF16746.5 EMC89552.1 - 6.3e-05 22.8 5.3 0.00093 19.0 5.3 2.2 1 1 0 1 1 1 1 BAR domain of APPL family MRF_C1 PF13887.6 EMC89552.1 - 0.027 13.6 0.2 0.18 11.0 0.1 2.2 2 0 0 2 2 2 0 Myelin gene regulatory factor -C-terminal domain 1 DNA_pol_B_2 PF03175.13 EMC89552.1 - 0.099 11.5 0.9 0.14 11.0 0.9 1.1 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral Exonuc_VII_L PF02601.15 EMC89552.1 - 1 8.8 4.7 1.6 8.3 4.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FH2 PF02181.23 EMC89552.1 - 1.6 7.7 10.3 0.8 8.8 7.6 1.8 2 1 0 2 2 2 0 Formin Homology 2 Domain Fib_alpha PF08702.10 EMC89553.1 - 0.00017 21.8 35.7 0.011 16.0 10.3 3.5 1 1 3 4 4 4 2 Fibrinogen alpha/beta chain family TMF_DNA_bd PF12329.8 EMC89553.1 - 0.00055 19.9 9.1 0.00055 19.9 9.1 6.2 3 2 3 6 6 5 1 TATA element modulatory factor 1 DNA binding Spc29 PF17082.5 EMC89553.1 - 0.0012 18.7 6.0 0.0012 18.7 6.0 3.5 1 1 1 2 2 1 1 Spindle Pole Component 29 Tropomyosin_1 PF12718.7 EMC89553.1 - 0.0027 17.8 23.2 0.0027 17.8 23.2 3.9 1 1 1 3 3 3 2 Tropomyosin like Fez1 PF06818.15 EMC89553.1 - 0.0043 17.5 25.5 0.0043 17.5 25.5 2.9 2 1 1 3 3 3 1 Fez1 HrpB7 PF09486.10 EMC89553.1 - 0.0066 16.8 24.3 0.01 16.2 3.8 3.0 1 1 0 2 2 2 2 Bacterial type III secretion protein (HrpB7) BRE1 PF08647.11 EMC89553.1 - 0.0098 15.9 16.8 0.0098 15.9 16.8 4.5 2 2 2 4 4 3 2 BRE1 E3 ubiquitin ligase PGA_cap PF09587.10 EMC89553.1 - 0.01 15.3 1.7 0.016 14.7 0.1 2.1 1 1 1 2 2 2 1 Bacterial capsule synthesis protein PGA_cap Uteroglobin PF01099.17 EMC89553.1 - 0.04 14.3 0.9 0.04 14.3 0.9 3.6 4 1 1 5 5 4 0 Uteroglobin family Atg14 PF10186.9 EMC89553.1 - 0.079 12.0 47.8 0.11 11.6 19.5 3.2 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 TRAF_BIRC3_bd PF16673.5 EMC89553.1 - 0.16 11.8 23.5 0.27 11.1 3.2 4.9 4 2 1 5 5 5 0 TNF receptor-associated factor BIRC3 binding domain DUF641 PF04859.12 EMC89553.1 - 0.37 11.1 39.4 0.21 11.9 8.0 4.6 2 2 3 5 5 5 0 Plant protein of unknown function (DUF641) DUF1664 PF07889.12 EMC89553.1 - 0.67 10.0 29.8 0.2 11.7 2.5 4.2 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) FliJ PF02050.16 EMC89553.1 - 1.3 9.2 38.2 0.99 9.6 14.8 3.8 1 1 2 3 3 3 0 Flagellar FliJ protein SKA1 PF07160.12 EMC89553.1 - 1.8 8.4 41.5 1.9 8.3 9.5 3.3 1 1 2 3 3 3 0 Spindle and kinetochore-associated protein 1 Spc7 PF08317.11 EMC89553.1 - 2.1 7.1 57.8 0.1 11.5 12.5 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein DUF948 PF06103.11 EMC89553.1 - 2.2 8.6 19.7 11 6.3 0.8 4.2 1 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) CALCOCO1 PF07888.11 EMC89553.1 - 2.6 6.8 53.3 0.018 13.9 18.5 3.4 1 1 2 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like NPV_P10 PF05531.12 EMC89553.1 - 2.8 8.4 19.0 2.5 8.6 1.0 4.5 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF5082 PF16888.5 EMC89553.1 - 3 8.2 38.0 0.38 11.0 5.1 4.9 1 1 4 5 5 5 0 Domain of unknown function (DUF5082) Cluap1 PF10234.9 EMC89553.1 - 4.8 6.5 46.1 0.33 10.3 24.5 2.3 1 1 1 2 2 2 0 Clusterin-associated protein-1 DUF1192 PF06698.11 EMC89553.1 - 5 7.3 10.4 0.69 10.0 1.1 3.9 4 1 0 4 4 4 0 Protein of unknown function (DUF1192) ADIP PF11559.8 EMC89553.1 - 7.3 6.7 54.6 0.033 14.3 18.6 4.5 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 EMC89553.1 - 8.9 6.5 51.7 0.67 10.2 20.3 4.1 1 1 2 3 3 2 0 Autophagy protein 16 (ATG16) zf-C2H2 PF00096.26 EMC89554.1 - 1.2e-10 41.3 32.8 0.004 17.5 1.8 7.1 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-met PF12874.7 EMC89554.1 - 7.7e-08 32.5 18.9 0.0049 17.2 0.1 5.6 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EMC89554.1 - 4.5e-07 30.2 35.8 0.0072 17.1 1.1 7.4 7 0 0 7 7 7 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC89554.1 - 1.3e-05 25.3 14.7 0.1 13.0 0.6 4.8 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-C2H2_aberr PF17017.5 EMC89554.1 - 0.06 13.5 10.0 0.24 11.6 0.3 3.6 3 0 0 3 3 3 0 Aberrant zinc-finger DUF5472 PF17566.2 EMC89554.1 - 1.1 9.2 6.0 40 4.3 0.1 3.5 3 0 0 3 3 3 0 Family of unknown function (DUF5472) Yae1_N PF09811.9 EMC89555.1 - 8.5e-08 31.8 43.1 0.00068 19.3 6.5 4.5 1 1 2 3 3 3 3 Essential protein Yae1, N terminal Yae1_N PF09811.9 EMC89556.1 - 1.6e-07 30.9 62.0 0.0058 16.3 5.4 5.3 3 1 1 4 4 4 4 Essential protein Yae1, N terminal LEDGF PF11467.8 EMC89557.1 - 8e-29 99.7 5.5 3.6e-28 97.6 5.5 2.2 1 0 0 1 1 1 1 Lens epithelium-derived growth factor (LEDGF) PWWP PF00855.17 EMC89557.1 - 6e-14 52.2 0.1 6e-14 52.2 0.1 4.7 2 1 1 3 3 3 1 PWWP domain Auxin_canalis PF05703.11 EMC89557.1 - 0.0076 16.2 7.1 0.0076 16.2 7.1 3.2 2 1 0 2 2 2 1 Auxin canalisation zf-SNAP50_C PF12251.8 EMC89558.1 - 5.1e-76 254.8 3.7 6.6e-76 254.4 3.7 1.1 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal DUF3808 PF10300.9 EMC89559.1 - 1.3e-165 551.8 10.0 1.6e-165 551.5 10.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_12 PF13424.6 EMC89559.1 - 9.5e-10 38.6 5.1 5.6e-05 23.3 0.1 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 EMC89559.1 - 1.3e-08 34.2 14.1 0.068 13.3 0.6 6.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 EMC89559.1 - 0.00014 21.6 11.3 0.11 12.3 0.4 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMC89559.1 - 0.0036 17.2 2.6 0.19 11.8 0.2 3.9 5 0 0 5 5 5 1 Tetratricopeptide repeat B1 PF02246.15 EMC89559.1 - 0.03 14.3 0.1 0.14 12.2 0.0 2.1 2 0 0 2 2 2 0 Protein L b1 domain TPR_16 PF13432.6 EMC89559.1 - 0.033 14.9 1.7 62 4.4 0.0 4.7 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 EMC89559.1 - 0.037 14.2 8.3 1.1 9.7 0.9 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 EMC89559.1 - 0.054 14.3 1.0 40 5.4 0.0 4.3 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EMC89559.1 - 0.085 13.4 0.0 0.085 13.4 0.0 4.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMC89559.1 - 0.13 13.0 16.7 0.27 11.9 0.7 6.7 7 1 0 7 7 7 0 Tetratricopeptide repeat Cadherin_3 PF16184.5 EMC89560.1 - 7.3e-238 772.9 18.7 3.5e-28 97.8 0.1 13.9 13 1 0 13 13 13 12 Cadherin-like Big_9 PF17963.1 EMC89560.1 - 7.9e-18 65.0 3.3 0.78 10.5 0.3 10.2 10 1 0 10 10 10 5 Bacterial Ig domain Cadherin_4 PF17803.1 EMC89560.1 - 2.2e-14 53.8 0.1 0.14 12.8 0.1 8.9 9 0 0 9 9 9 3 Bacterial cadherin-like domain Calx-beta PF03160.14 EMC89560.1 - 5.2e-11 42.6 0.1 2.1e-10 40.7 0.1 2.1 1 0 0 1 1 1 1 Calx-beta domain Lectin_C PF00059.21 EMC89560.1 - 8.2e-11 42.6 4.0 2.2e-10 41.2 4.0 1.8 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 EMC89560.1 - 0.19 11.4 0.1 0.35 10.5 0.1 1.3 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like DAN PF03045.15 EMC89561.1 - 4.1e-29 100.9 8.4 7.6e-29 100.0 8.4 1.4 1 0 0 1 1 1 1 DAN domain Cys_knot PF00007.22 EMC89561.1 - 0.0009 19.5 6.6 0.0014 18.9 6.6 1.2 1 0 0 1 1 1 1 Cystine-knot domain Sclerostin PF05463.11 EMC89561.1 - 0.0011 18.8 2.5 0.0034 17.1 2.5 1.7 1 1 0 1 1 1 1 Sclerostin (SOST) DUF1661 PF07877.11 EMC89561.1 - 0.11 12.2 1.2 0.27 11.0 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1661) VASP_tetra PF08776.11 EMC89561.1 - 0.12 12.0 0.1 0.21 11.2 0.1 1.4 1 0 0 1 1 1 0 VASP tetramerisation domain DHHC PF01529.20 EMC89562.1 - 2.3e-33 115.1 11.3 2.3e-33 115.1 11.3 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase MH1 PF03165.16 EMC89563.1 - 1.5e-12 47.6 1.3 3e-12 46.6 1.3 1.5 1 1 0 1 1 1 1 MH1 domain CTF_NFI PF00859.18 EMC89564.1 - 4.6e-106 355.0 25.2 6.2e-106 354.6 25.2 1.2 1 0 0 1 1 1 1 CTF/NF-I family transcription modulation region DUF3383 PF11863.8 EMC89564.1 - 0.052 12.6 0.0 0.068 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3383) Sema PF01403.19 EMC89566.1 - 3.3e-41 141.5 0.0 3.6e-41 141.4 0.0 1.0 1 0 0 1 1 1 1 Sema domain IL17 PF06083.11 EMC89567.1 - 2.1e-30 105.0 0.9 3.8e-30 104.2 0.3 1.7 2 0 0 2 2 2 1 Interleukin-17 IL17 PF06083.11 EMC89568.1 - 4.4e-30 104.0 0.0 7.4e-30 103.3 0.0 1.4 1 0 0 1 1 1 1 Interleukin-17 HlyIII PF03006.20 EMC89569.1 - 5.9e-51 173.3 16.1 9.7e-51 172.6 16.1 1.3 1 0 0 1 1 1 1 Haemolysin-III related DUF5504 PF17608.2 EMC89569.1 - 0.014 15.5 4.3 0.033 14.3 4.3 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5504) DUF1126 PF06565.12 EMC89570.1 - 5.5e-103 337.9 7.8 4.1e-35 119.8 0.7 3.7 4 0 0 4 4 4 3 DUF1126 PH-like domain TRAM_LAG1_CLN8 PF03798.16 EMC89572.1 - 9.9e-23 80.9 16.5 9.9e-23 80.9 16.5 1.4 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 EMC89572.1 - 9.5e-19 66.8 0.3 9.5e-19 66.8 0.3 2.4 2 0 0 2 2 2 1 TRAM1-like protein AA_permease_2 PF13520.6 EMC89572.1 - 0.00092 18.1 1.2 0.0012 17.8 0.5 1.4 1 1 0 1 1 1 1 Amino acid permease DUF2207 PF09972.9 EMC89572.1 - 0.1 11.4 1.7 0.18 10.5 1.7 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4834 PF16118.5 EMC89572.1 - 0.7 10.9 4.4 15 6.6 0.3 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) AKAP7_RIRII_bdg PF10470.9 EMC89575.1 - 7.3e-06 26.0 3.8 7.7e-06 25.9 3.8 1.1 1 0 0 1 1 1 1 PKA-RI-RII subunit binding domain of A-kinase anchor protein BTB PF00651.31 EMC89576.1 - 2.8e-28 98.4 0.8 5.2e-28 97.5 0.8 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.26 EMC89576.1 - 1.7e-25 88.0 32.5 2.1e-05 24.7 0.2 5.7 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC89576.1 - 2.7e-23 81.3 47.7 9.3e-07 29.0 2.6 6.5 7 0 0 7 7 6 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC89576.1 - 2.1e-15 56.1 37.8 0.0043 17.8 1.1 5.8 6 0 0 6 6 5 5 C2H2-type zinc finger zf-met PF12874.7 EMC89576.1 - 2.5e-13 49.9 21.2 0.0051 17.2 0.6 5.6 5 0 0 5 5 5 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMC89576.1 - 2.9e-13 49.7 23.8 0.0063 16.8 0.2 5.8 6 0 0 6 6 5 5 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 EMC89576.1 - 0.013 16.0 36.4 1.5 9.3 6.4 6.5 3 3 2 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger zf-MYST PF17772.1 EMC89576.1 - 0.014 15.0 15.2 0.59 9.8 0.2 5.1 3 2 2 5 5 5 0 MYST family zinc finger domain LIM PF00412.22 EMC89576.1 - 0.047 13.9 21.5 0.44 10.8 0.4 4.6 2 2 2 4 4 4 0 LIM domain zf-C2HC_2 PF13913.6 EMC89576.1 - 0.075 12.9 5.6 1.6 8.7 0.1 3.4 3 0 0 3 3 3 0 zinc-finger of a C2HC-type BTB_2 PF02214.22 EMC89576.1 - 0.086 13.2 0.1 0.26 11.6 0.1 1.9 1 0 0 1 1 1 0 BTB/POZ domain zf_UBZ PF18439.1 EMC89576.1 - 0.13 11.8 15.5 1.5 8.5 0.2 5.0 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger zf-C2H2_3rep PF18868.1 EMC89576.1 - 0.18 12.5 15.0 2.9 8.6 2.7 4.2 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_11 PF16622.5 EMC89576.1 - 0.19 11.5 9.6 8.8 6.2 0.0 4.5 4 0 0 4 4 4 0 zinc-finger C2H2-type C1_4 PF07975.12 EMC89576.1 - 0.32 11.3 16.0 5.5 7.3 1.7 4.1 1 1 1 3 3 3 0 TFIIH C1-like domain zf-Di19 PF05605.12 EMC89576.1 - 0.74 10.1 23.3 0.47 10.8 3.3 3.3 1 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_15 PF17032.5 EMC89576.1 - 2.6 8.8 16.7 5.7 7.8 2.1 3.7 2 1 3 5 5 4 0 zinc-ribbon family ADK_lid PF05191.14 EMC89576.1 - 4.2 7.4 6.7 7.4 6.7 2.2 3.0 2 1 1 3 3 3 0 Adenylate kinase, active site lid zf-C2H2_6 PF13912.6 EMC89576.1 - 4.9 7.3 32.0 4.5 7.4 0.4 5.8 5 1 0 5 5 5 0 C2H2-type zinc finger zf-trcl PF13451.6 EMC89576.1 - 8.4 6.4 16.6 41 4.2 0.1 5.0 4 1 0 4 4 4 0 Probable zinc-ribbon domain Zn-ribbon_8 PF09723.10 EMC89576.1 - 9.6 6.4 19.9 20 5.4 2.2 4.6 2 2 2 4 4 4 0 Zinc ribbon domain 4_1_CTD PF05902.13 EMC89577.1 - 8.1e-52 173.8 15.2 8.1e-52 173.8 15.2 3.3 4 0 0 4 4 4 1 4.1 protein C-terminal domain (CTD) SAB PF04382.13 EMC89577.1 - 2.3e-25 88.4 2.5 7e-25 86.9 2.5 1.9 1 0 0 1 1 1 1 SAB domain FERM_C PF09380.10 EMC89577.1 - 6.9e-24 84.1 0.0 1.6e-23 82.9 0.0 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.10 EMC89577.1 - 4.6e-21 74.5 0.1 3.3e-20 71.8 0.1 2.4 2 0 0 2 2 2 1 FERM N-terminal domain FERM_M PF00373.18 EMC89577.1 - 2.9e-19 69.6 0.0 2.9e-19 69.6 0.0 2.7 3 1 0 3 3 3 1 FERM central domain FA PF08736.11 EMC89577.1 - 7.2e-19 67.6 4.3 2.1e-18 66.1 4.3 1.9 1 0 0 1 1 1 1 FERM adjacent (FA) GAPT PF11770.8 EMC89577.1 - 0.15 11.9 0.5 4.6 7.1 0.0 2.9 3 0 0 3 3 3 0 GRB2-binding adapter (GAPT) RNA_pol_Rpc4 PF05132.14 EMC89577.1 - 0.19 12.1 0.0 0.19 12.1 0.0 4.1 4 1 0 4 4 4 0 RNA polymerase III RPC4 7tm_4 PF13853.6 EMC89578.1 - 5e-22 78.9 1.3 5.6e-22 78.8 1.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC89578.1 - 9.9e-05 21.8 2.5 0.00014 21.3 2.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) OSTMP1 PF09777.9 EMC89578.1 - 0.17 11.3 1.1 0.24 10.8 1.1 1.1 1 0 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor AMP-binding PF00501.28 EMC89580.1 - 2.5e-09 36.2 0.2 2.6e-09 36.2 0.2 1.0 1 0 0 1 1 1 1 AMP-binding enzyme p450 PF00067.22 EMC89581.1 - 3.4e-37 128.3 2.3 3.4e-21 75.5 0.1 3.1 1 1 2 3 3 3 3 Cytochrome P450 Nop14 PF04147.12 EMC89582.1 - 0.44 8.7 43.8 0.61 8.2 43.8 1.1 1 0 0 1 1 1 0 Nop14-like family Zip PF02535.22 EMC89582.1 - 0.64 9.2 8.8 1 8.5 8.8 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Mpp10 PF04006.12 EMC89582.1 - 3 6.2 41.2 3.8 5.8 41.2 1.0 1 0 0 1 1 1 0 Mpp10 protein V_ATPase_I PF01496.19 EMC89582.1 - 3.4 5.5 8.4 4.5 5.1 8.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Tim54 PF11711.8 EMC89582.1 - 4.6 5.9 12.2 6.8 5.4 12.2 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF913 PF06025.12 EMC89582.1 - 5.7 5.8 9.3 9 5.2 9.3 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) V-set PF07686.17 EMC89583.1 - 3.4e-07 30.4 1.7 1.1e-06 28.8 1.7 1.7 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC89583.1 - 0.00061 20.3 0.8 0.00076 20.0 0.8 1.2 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC89583.1 - 0.0097 16.0 0.4 0.014 15.4 0.4 1.3 1 1 0 1 1 1 1 Immunoglobulin I-set domain DUF4747 PF15931.5 EMC89583.1 - 0.2 11.3 0.1 0.31 10.6 0.1 1.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4747) 7tm_4 PF13853.6 EMC89584.1 - 8.6e-42 143.8 20.9 1.2e-41 143.3 20.9 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC89584.1 - 8.2e-22 77.8 18.9 1.3e-21 77.1 18.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC89585.1 - 3.8e-30 105.6 9.7 4.8e-30 105.2 9.7 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC89585.1 - 1.6e-20 73.6 8.9 2.3e-20 73.0 8.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC89585.1 - 8.1e-05 22.1 13.8 0.00011 21.7 13.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx PNTB_4TM PF12769.7 EMC89585.1 - 0.011 16.1 4.6 0.028 14.9 4.6 1.6 1 0 0 1 1 1 0 4TM region of pyridine nucleotide transhydrogenase, mitoch Keratin PF02422.16 EMC89586.1 - 5.5e-29 99.7 16.9 6.1e-29 99.6 16.9 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 EMC89587.1 - 6.5e-33 112.3 15.7 7.1e-33 112.2 15.7 1.0 1 0 0 1 1 1 1 Keratin DUF3432 PF11914.8 EMC89587.1 - 0.67 10.2 10.6 1.4 9.2 10.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3432) UQ_con PF00179.26 EMC89588.1 - 2e-18 66.4 0.0 2.2e-18 66.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EMC89588.1 - 0.032 14.5 0.0 0.034 14.4 0.0 1.2 1 0 0 1 1 1 0 RWD domain Voltage_CLC PF00654.20 EMC89589.1 - 2.2e-23 83.1 8.8 2.5e-23 82.9 8.8 1.0 1 0 0 1 1 1 1 Voltage gated chloride channel zf-C2H2 PF00096.26 EMC89590.1 - 3.8e-28 96.3 31.2 2.8e-06 27.4 1.3 5.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC89590.1 - 5.4e-21 73.5 31.1 6.1e-05 23.5 1.1 5.7 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC89590.1 - 1.4e-18 66.3 32.5 4.7e-08 33.1 0.5 5.9 5 1 0 5 5 5 5 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EMC89590.1 - 2.4e-14 53.2 25.6 0.00052 20.2 0.1 6.4 6 0 0 6 6 6 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMC89590.1 - 3.4e-09 36.5 29.0 0.0012 18.8 0.7 5.5 5 0 0 5 5 5 5 C2H2-type zinc finger zf-met PF12874.7 EMC89590.1 - 1.5e-08 34.7 25.4 0.0034 17.7 0.3 5.9 6 0 0 6 6 6 4 Zinc-finger of C2H2 type zf-Di19 PF05605.12 EMC89590.1 - 1.6e-07 31.5 16.7 0.0042 17.3 2.9 3.5 3 0 0 3 3 3 3 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.6 EMC89590.1 - 0.00027 20.7 15.9 1.1 9.2 1.1 5.4 5 0 0 5 5 5 2 zinc-finger of a C2HC-type zf-BED PF02892.15 EMC89590.1 - 0.0022 17.9 29.5 0.3 11.2 0.2 5.6 3 1 2 6 6 5 3 BED zinc finger Elf1 PF05129.13 EMC89590.1 - 0.0058 16.7 17.1 0.019 15.0 0.8 3.2 2 1 1 3 3 3 1 Transcription elongation factor Elf1 like zf-C2H2_2 PF12756.7 EMC89590.1 - 0.0074 16.6 21.5 1.7 9.0 0.3 5.0 1 1 4 5 5 5 2 C2H2 type zinc-finger (2 copies) zinc_ribbon_15 PF17032.5 EMC89590.1 - 0.0088 16.8 1.3 0.0088 16.8 1.3 2.9 2 1 0 2 2 1 1 zinc-ribbon family zf-H2C2_5 PF13909.6 EMC89590.1 - 0.039 13.7 0.6 0.039 13.7 0.6 5.2 4 1 0 4 4 3 0 C2H2-type zinc-finger domain PyrI_C PF02748.15 EMC89590.1 - 0.047 13.6 16.3 2.8 7.9 1.6 4.9 5 0 0 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Ogr_Delta PF04606.12 EMC89590.1 - 0.068 13.2 6.6 0.058 13.4 3.7 2.4 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger Zn-ribbon_8 PF09723.10 EMC89590.1 - 0.082 13.0 22.0 0.55 10.4 2.1 4.3 3 1 0 3 3 3 0 Zinc ribbon domain DUF4764 PF15961.5 EMC89590.1 - 0.61 8.7 6.6 1.7 7.3 1.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4764) zinc_ribbon_9 PF14369.6 EMC89590.1 - 1.2 9.4 9.3 0.72 10.2 0.3 4.0 4 0 0 4 4 4 0 zinc-ribbon zf_ZIC PF18366.1 EMC89590.1 - 1.2 9.3 13.8 13 6.0 1.5 4.9 2 2 3 5 5 5 0 Zic proteins zinc finger domain zf_UBZ PF18439.1 EMC89590.1 - 1.7 8.3 15.6 17 5.1 0.1 5.3 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger zf-LYAR PF08790.11 EMC89590.1 - 1.8 8.5 12.1 6.1 6.9 0.2 4.8 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger zf-AN1 PF01428.16 EMC89590.1 - 3.2 8.0 26.6 8.5 6.6 1.9 5.2 5 0 0 5 5 5 0 AN1-like Zinc finger zf-CHY PF05495.12 EMC89590.1 - 6 7.4 25.3 1.1 9.7 6.4 2.7 1 1 0 2 2 2 0 CHY zinc finger HPP PF04982.13 EMC89591.1 - 7.9 6.7 22.6 2.6 8.3 13.0 3.1 1 1 1 2 2 2 0 HPP family XendoU PF09412.10 EMC89592.1 - 2.6e-90 302.2 0.2 2.9e-90 302.1 0.2 1.0 1 0 0 1 1 1 1 Endoribonuclease XendoU EndoU_bacteria PF14436.6 EMC89592.1 - 0.00088 19.6 0.0 0.0018 18.6 0.0 1.5 1 0 0 1 1 1 1 Bacterial EndoU nuclease PAH PF02671.21 EMC89592.1 - 0.046 13.9 0.1 0.11 12.7 0.1 1.6 1 0 0 1 1 1 0 Paired amphipathic helix repeat zf-H2C2_2 PF13465.6 EMC89594.1 - 3.6e-14 52.4 26.2 1e-07 32.1 3.0 4.4 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 EMC89594.1 - 1.6e-13 50.3 26.1 2.6e-05 24.4 1.0 4.3 3 1 1 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC89594.1 - 4.7e-08 33.2 26.4 0.00035 21.2 1.7 4.3 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EMC89594.1 - 0.0061 16.8 2.2 0.019 15.2 2.2 1.9 1 0 0 1 1 1 1 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 EMC89594.1 - 0.017 15.4 3.4 2.2 8.7 0.8 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 EMC89594.1 - 6.5 7.1 13.5 3 8.2 2.6 3.2 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding WD40 PF00400.32 EMC89595.1 - 5.1e-08 33.5 5.1 1.4e-05 25.7 0.0 3.7 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC89595.1 - 0.00011 22.4 0.2 0.089 13.1 0.0 3.4 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EMC89595.1 - 0.00015 21.6 1.3 0.17 11.9 0.1 2.7 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat WDCP PF15390.6 EMC89595.1 - 0.0049 15.3 3.3 0.39 9.1 1.1 2.0 1 1 1 2 2 2 2 WD repeat and coiled-coil-containing protein family eIF2A PF08662.11 EMC89595.1 - 0.0098 15.8 0.0 0.023 14.6 0.0 1.6 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A zf-C4 PF00105.18 EMC89596.1 - 7e-29 100.1 15.8 1.2e-28 99.3 15.8 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 EMC89596.1 - 4.2e-24 85.3 2.8 4.8e-24 85.1 0.6 1.9 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-RRPl_C4 PF17026.5 EMC89596.1 - 0.031 14.4 3.2 0.071 13.2 3.2 1.7 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type DUF1356 PF07092.12 EMC89597.1 - 3.6e-90 301.3 3.9 4e-90 301.1 3.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1356) Anti-TRAP PF15777.5 EMC89597.1 - 0.00035 20.5 0.1 0.00061 19.7 0.1 1.3 1 0 0 1 1 1 1 Tryptophan RNA-binding attenuator protein inhibitory protein LEA_2 PF03168.13 EMC89597.1 - 0.00057 20.4 0.3 0.00091 19.7 0.3 1.3 1 0 0 1 1 1 1 Late embryogenesis abundant protein DnaJ_CXXCXGXG PF00684.19 EMC89597.1 - 0.041 14.2 0.0 0.07 13.5 0.0 1.3 1 0 0 1 1 1 0 DnaJ central domain EbsA PF17255.2 EMC89597.1 - 0.065 13.6 0.4 0.092 13.1 0.4 1.2 1 0 0 1 1 1 0 EbsA-like protein Ank_4 PF13637.6 EMC89598.1 - 9.9e-30 102.5 1.5 4.3e-09 36.7 0.2 4.9 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EMC89598.1 - 3.2e-29 100.0 0.3 1.2e-05 25.5 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_2 PF12796.7 EMC89598.1 - 2.1e-28 98.7 0.3 1e-12 48.5 0.3 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC89598.1 - 1.3e-23 80.5 1.4 0.00012 22.2 0.0 5.0 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 EMC89598.1 - 2.4e-21 75.5 3.2 3.8e-09 36.6 0.2 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) SOCS_box PF07525.16 EMC89598.1 - 9.7e-05 22.7 0.0 0.00018 21.8 0.0 1.5 1 0 0 1 1 1 1 SOCS box zf-H2C2_2 PF13465.6 EMC89599.1 - 3.8e-10 39.7 7.5 5.9e-06 26.5 0.8 2.0 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.26 EMC89599.1 - 2.4e-07 30.9 0.6 2.4e-07 30.9 0.6 2.1 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC89599.1 - 9.8e-05 22.9 0.5 9.8e-05 22.9 0.5 1.8 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC89599.1 - 0.0036 17.3 0.5 0.0036 17.3 0.5 1.8 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EMC89599.1 - 0.0079 15.9 0.5 0.011 15.5 0.5 1.2 1 0 0 1 1 1 1 zinc-finger C2H2-type DNA_RNApol_7kD PF03604.13 EMC89599.1 - 0.015 15.0 0.1 0.02 14.6 0.1 1.2 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit WD40 PF00400.32 EMC89603.1 - 1.8e-07 31.7 1.4 0.00019 22.1 0.1 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC89603.1 - 0.0042 17.4 0.0 0.48 10.8 0.0 2.7 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain SMP_LBD PF17047.5 EMC89604.1 - 7e-68 227.6 1.0 1.3e-64 217.0 1.0 2.2 1 1 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain PIN_10 PF18478.1 EMC89604.1 - 0.1 12.8 0.1 0.23 11.7 0.1 1.5 1 0 0 1 1 1 0 PIN like domain SPATA6 PF14909.6 EMC89605.1 - 1.2e-24 87.0 0.5 1.6e-24 86.6 0.5 1.2 1 0 0 1 1 1 1 Spermatogenesis-assoc protein 6 CDC37_M PF08565.11 EMC89606.1 - 5.5e-20 71.5 0.1 1.1e-19 70.5 0.1 1.5 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain PMM PF03332.13 EMC89606.1 - 0.098 12.4 0.1 0.16 11.7 0.1 1.3 1 0 0 1 1 1 0 Eukaryotic phosphomannomutase ADK PF00406.22 EMC89607.1 - 2.2e-31 109.0 0.0 2.6e-31 108.8 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.14 EMC89607.1 - 1.1e-16 60.5 0.0 2.4e-16 59.4 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.6 EMC89607.1 - 6.9e-05 23.3 0.0 0.00015 22.2 0.0 1.6 2 0 0 2 2 2 1 AAA domain Myosin_tail_1 PF01576.19 EMC89608.1 - 1.7e-42 145.4 68.6 1.9e-42 145.2 68.6 1.0 1 0 0 1 1 1 1 Myosin tail Tropomyosin PF00261.20 EMC89608.1 - 4.1e-05 23.1 68.9 0.0067 15.8 30.4 4.5 1 1 4 5 5 5 4 Tropomyosin DUF3958 PF13125.6 EMC89608.1 - 0.018 15.3 11.7 0.018 15.3 11.7 5.3 2 2 3 5 5 5 0 Protein of unknown function (DUF3958) Tropomyosin_1 PF12718.7 EMC89608.1 - 0.14 12.3 67.5 5 7.3 13.0 4.5 1 1 3 4 4 4 0 Tropomyosin like MAD PF05557.13 EMC89608.1 - 0.24 9.7 64.6 0.047 12.1 19.8 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein DUF1664 PF07889.12 EMC89608.1 - 0.96 9.5 42.7 1.4 8.9 5.8 4.5 1 1 2 4 4 4 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 EMC89608.1 - 1.1 9.4 41.5 0.043 14.0 14.3 3.7 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Laminin_II PF06009.12 EMC89608.1 - 1.5 8.8 46.1 0.86 9.6 3.5 4.7 1 1 4 5 5 5 0 Laminin Domain II Uso1_p115_C PF04871.13 EMC89608.1 - 1.8 8.9 65.3 13 6.2 12.0 5.0 1 1 4 5 5 5 0 Uso1 / p115 like vesicle tethering protein, C terminal region ATG16 PF08614.11 EMC89608.1 - 2.7 8.1 69.7 0.56 10.4 22.0 3.5 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 EMC89608.1 - 3.9 7.6 69.8 0.54 10.3 17.6 4.1 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein DUF745 PF05335.13 EMC89608.1 - 4.6 6.9 53.5 11 5.7 14.4 4.2 1 1 2 3 3 3 0 Protein of unknown function (DUF745) PspA_IM30 PF04012.12 EMC89608.1 - 4.8 6.7 68.4 2.5 7.6 36.2 4.0 1 1 3 4 4 4 0 PspA/IM30 family MscS_porin PF12795.7 EMC89608.1 - 9.9 5.6 60.5 0.66 9.5 21.7 2.3 1 1 0 2 2 2 0 Mechanosensitive ion channel porin domain Auts2 PF15336.6 EMC89610.1 - 1.5e-106 355.4 15.2 1.5e-106 355.4 15.2 5.1 3 2 1 5 5 5 1 Autism susceptibility gene 2 protein Rep_fac_C PF08542.11 EMC89612.1 - 1.3e-26 92.8 0.0 3.6e-26 91.4 0.0 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 EMC89612.1 - 1.8e-13 51.1 0.1 3e-13 50.3 0.1 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EMC89612.1 - 3.4e-12 46.5 0.0 3.3e-10 40.0 0.1 2.2 1 1 1 2 2 2 1 DNA polymerase III, delta subunit AAA_14 PF13173.6 EMC89612.1 - 3e-06 27.3 0.0 5e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EMC89612.1 - 5.5e-06 26.9 0.0 0.00069 20.0 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EMC89612.1 - 6.2e-06 26.5 0.2 0.028 14.7 0.1 2.5 1 1 1 2 2 2 2 AAA domain AAA_24 PF13479.6 EMC89612.1 - 3.6e-05 23.6 0.0 7.6e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EMC89612.1 - 4.7e-05 23.2 0.0 8.9e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 EMC89612.1 - 7.6e-05 22.6 0.0 9.4e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EMC89612.1 - 0.00011 21.6 0.0 0.0018 17.7 0.0 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 EMC89612.1 - 0.00076 19.8 0.5 0.0033 17.8 0.5 2.1 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMC89612.1 - 0.0014 19.2 0.0 0.0038 17.8 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_assoc_2 PF16193.5 EMC89612.1 - 0.0014 18.9 0.0 0.0041 17.4 0.0 1.9 2 0 0 2 2 1 1 AAA C-terminal domain MipZ PF09140.11 EMC89612.1 - 0.0016 17.8 0.1 0.0021 17.4 0.1 1.1 1 0 0 1 1 1 1 ATPase MipZ TniB PF05621.11 EMC89612.1 - 0.002 17.6 0.1 2.2 7.6 0.0 2.4 2 0 0 2 2 2 2 Bacterial TniB protein RuvB_N PF05496.12 EMC89612.1 - 0.0022 17.8 0.0 0.0062 16.3 0.0 2.0 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EMC89612.1 - 0.004 17.2 0.0 0.011 15.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EMC89612.1 - 0.0042 16.7 0.2 0.013 15.0 0.2 1.8 1 1 1 2 2 2 1 AAA domain AAA_30 PF13604.6 EMC89612.1 - 0.0053 16.5 0.2 0.016 14.9 0.2 1.8 1 1 0 1 1 1 1 AAA domain DEAD PF00270.29 EMC89612.1 - 0.0077 16.0 1.2 0.43 10.3 0.0 2.6 2 1 1 3 3 3 1 DEAD/DEAH box helicase ABC_tran PF00005.27 EMC89612.1 - 0.014 15.9 0.0 0.041 14.4 0.0 1.6 1 1 0 1 1 1 0 ABC transporter Rad17 PF03215.15 EMC89612.1 - 0.019 14.9 0.0 0.058 13.3 0.0 1.8 1 1 1 2 2 2 0 Rad17 P-loop domain ResIII PF04851.15 EMC89612.1 - 0.031 14.3 0.2 13 5.8 0.0 3.0 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit AAA_28 PF13521.6 EMC89612.1 - 0.032 14.5 0.1 0.055 13.7 0.1 1.5 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EMC89612.1 - 0.039 13.9 0.3 0.18 11.7 0.1 2.1 2 0 0 2 2 2 0 NTPase MeaB PF03308.16 EMC89612.1 - 0.048 12.6 0.0 0.083 11.9 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF2075 PF09848.9 EMC89612.1 - 0.053 12.8 0.6 1.2 8.3 0.6 2.2 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) FtsK_SpoIIIE PF01580.18 EMC89612.1 - 0.055 12.8 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family T2SSE PF00437.20 EMC89612.1 - 0.063 12.3 0.0 0.1 11.7 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_23 PF13476.6 EMC89612.1 - 0.073 13.6 0.0 0.12 12.8 0.0 1.4 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EMC89612.1 - 0.078 13.4 0.0 0.26 11.7 0.0 2.0 1 1 0 1 1 1 0 RNA helicase DUF4597 PF15366.6 EMC89612.1 - 0.083 12.7 0.7 3.1 7.6 0.1 2.6 3 0 0 3 3 2 0 Domain of unknown function (DUF4597) DNA_pol3_delta PF06144.13 EMC89612.1 - 0.14 11.9 0.1 0.27 11.0 0.1 1.4 1 0 0 1 1 1 0 DNA polymerase III, delta subunit IstB_IS21 PF01695.17 EMC89612.1 - 0.15 11.8 0.1 0.33 10.7 0.1 1.7 1 1 0 1 1 1 0 IstB-like ATP binding protein LAT2 PF15703.5 EMC89613.1 - 6.1e-40 137.0 0.8 7.1e-40 136.8 0.8 1.0 1 0 0 1 1 1 1 Linker for activation of T-cells family member 2 RRM_1 PF00076.22 EMC89614.1 - 1.7e-13 50.1 0.0 2.6e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DNA_pol_phi PF04931.13 EMC89615.1 - 1.3e-167 559.3 25.3 1.5e-167 559.0 25.3 1.0 1 0 0 1 1 1 1 DNA polymerase phi DUF3798 PF12683.7 EMC89615.1 - 0.055 12.9 0.0 0.091 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3798) Rgp1 PF08737.10 EMC89615.1 - 0.057 12.6 3.2 0.16 11.1 3.2 1.7 1 0 0 1 1 1 0 Rgp1 DUF4604 PF15377.6 EMC89615.1 - 0.77 10.2 15.7 0.37 11.2 11.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) Nop14 PF04147.12 EMC89615.1 - 2.2 6.4 18.8 4.8 5.3 18.8 1.5 1 0 0 1 1 1 0 Nop14-like family MFS_1 PF07690.16 EMC89617.1 - 1.5e-29 103.0 29.6 1.8e-29 102.8 29.6 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMC89617.1 - 2.5e-12 46.4 9.9 2.5e-12 46.4 9.9 2.3 2 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 EMC89617.1 - 1.5e-09 36.7 21.3 6.8e-07 28.0 1.3 4.1 2 2 2 4 4 4 4 Organic Anion Transporter Polypeptide (OATP) family Amelogenin PF02948.15 EMC89618.1 - 0.013 16.2 49.9 3.7 8.2 16.8 5.0 1 1 2 3 3 3 0 Amelogenin Prot_ATP_ID_OB PF16450.5 EMC89618.1 - 0.081 12.9 5.6 1.7e+02 2.2 0.0 5.3 5 0 0 5 5 5 0 Proteasomal ATPase OB C-terminal domain DUF1518 PF07469.12 EMC89618.1 - 0.53 10.7 33.3 5.4 7.5 0.5 5.8 2 1 4 6 6 6 0 Domain of unknown function (DUF1518) DUF4573 PF15140.6 EMC89618.1 - 1.7 8.4 24.4 7.6 6.3 13.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4573) MAGUK_N_PEST PF10608.9 EMC89618.1 - 4.9 7.6 25.5 7.4 7.1 1.9 4.5 1 1 3 4 4 4 0 Polyubiquitination (PEST) N-terminal domain of MAGUK Collagen PF01391.18 EMC89619.1 - 2.2e-17 62.6 14.2 1.2e-05 24.9 4.3 3.5 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Chorion_1 PF01723.16 EMC89619.1 - 0.13 12.2 38.0 1.5 8.7 4.0 3.9 1 1 3 4 4 4 0 Chorion protein Tmemb_161AB PF10268.9 EMC89620.1 - 1.2e-212 706.7 14.9 1.4e-212 706.6 14.9 1.0 1 0 0 1 1 1 1 Predicted transmembrane protein 161AB zf-C3HC4_2 PF13923.6 EMC89621.1 - 1.5e-12 47.1 9.0 2.7e-12 46.3 9.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC89621.1 - 7.2e-11 41.8 9.1 1.2e-10 41.0 9.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC89621.1 - 2e-09 37.6 10.4 3.3e-09 36.9 10.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EMC89621.1 - 2.5e-09 36.9 6.5 3.7e-09 36.3 6.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC89621.1 - 2.6e-06 27.3 6.5 4.1e-06 26.6 6.5 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC89621.1 - 9.5e-06 25.4 6.8 1.6e-05 24.6 6.8 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EMC89621.1 - 0.00013 21.9 8.8 0.00025 21.0 8.8 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 EMC89621.1 - 0.00017 21.8 9.7 0.00045 20.4 9.7 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EMC89621.1 - 0.0064 16.2 5.6 0.013 15.2 5.6 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-ANAPC11 PF12861.7 EMC89621.1 - 0.063 13.3 2.4 0.14 12.3 2.4 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Baculo_IE-1 PF05290.11 EMC89621.1 - 0.16 11.9 3.9 0.25 11.3 3.9 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-C3HC4_4 PF15227.6 EMC89621.1 - 1.1 9.5 11.6 2 8.7 11.6 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EMC89621.1 - 2 8.3 8.3 3.7 7.4 8.3 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain SRF-TF PF00319.18 EMC89622.1 - 3.1e-24 84.2 0.4 5.2e-24 83.5 0.4 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.8 EMC89622.1 - 4.3e-18 65.1 0.4 2.5e-17 62.7 0.1 2.2 2 0 0 2 2 2 1 Holliday junction regulator protein family C-terminal repeat GHD PF17834.1 EMC89622.1 - 0.08 13.0 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Beta-sandwich domain in beta galactosidase EF-hand_1 PF00036.32 EMC89623.1 - 6.5e-22 75.4 13.8 1.7e-07 30.3 0.2 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EMC89623.1 - 8.9e-22 77.3 11.4 1e-10 41.9 2.4 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EMC89623.1 - 2.2e-18 64.6 10.1 6.9e-06 25.6 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EMC89623.1 - 3.2e-11 42.9 13.1 8.4e-05 22.3 0.2 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 EMC89623.1 - 1.9e-10 39.7 6.5 0.028 13.9 0.3 4.6 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 EMC89623.1 - 9.3e-07 29.1 0.6 0.037 14.4 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain Caleosin PF05042.13 EMC89623.1 - 0.0013 18.7 0.4 0.51 10.3 0.0 3.2 1 1 2 3 3 3 1 Caleosin related protein HTH_40 PF14493.6 EMC89623.1 - 0.0046 17.4 2.3 0.59 10.6 0.0 2.3 1 1 1 2 2 2 2 Helix-turn-helix domain EF-hand_14 PF17959.1 EMC89623.1 - 0.0082 16.5 2.6 0.46 10.9 0.2 2.4 1 1 1 2 2 2 1 EF-hand domain UBA_2 PF08587.11 EMC89623.1 - 0.036 14.2 0.1 2.2 8.5 0.0 2.8 2 1 0 2 2 2 0 Ubiquitin associated domain (UBA) EF-hand_4 PF12763.7 EMC89623.1 - 0.046 13.7 3.4 0.057 13.4 0.2 2.4 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand SurA_N_2 PF13623.6 EMC89623.1 - 0.082 12.8 0.3 7 6.5 0.2 2.2 2 0 0 2 2 2 0 SurA N-terminal domain MgtE_N PF03448.17 EMC89623.1 - 0.25 12.0 5.9 0.14 12.7 1.2 2.5 1 1 2 3 3 3 0 MgtE intracellular N domain SPARC_Ca_bdg PF10591.9 EMC89623.1 - 0.26 11.6 3.2 0.22 11.8 1.0 2.0 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region RNA_pol_3_Rpc31 PF11705.8 EMC89624.1 - 2.3e-33 116.3 20.4 3e-33 116.0 20.4 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 CDC27 PF09507.10 EMC89624.1 - 0.0001 21.8 13.5 0.00011 21.7 13.5 1.1 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 BUD22 PF09073.10 EMC89624.1 - 0.11 11.9 24.5 0.13 11.5 24.5 1.1 1 0 0 1 1 1 0 BUD22 DUF5094 PF17015.5 EMC89624.1 - 0.45 10.6 13.9 0.7 10.0 13.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) Rgp1 PF08737.10 EMC89624.1 - 0.77 8.9 5.2 0.87 8.7 5.2 1.1 1 0 0 1 1 1 0 Rgp1 DUF5427 PF10310.9 EMC89624.1 - 0.98 8.3 13.7 1.3 7.9 13.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) PA26 PF04636.13 EMC89624.1 - 1.4 7.8 5.8 1.7 7.5 5.8 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) SAPS PF04499.15 EMC89624.1 - 3 6.5 9.8 3.4 6.3 9.8 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF913 PF06025.12 EMC89624.1 - 3.4 6.5 6.9 4.2 6.3 6.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NOA36 PF06524.12 EMC89624.1 - 3.8 6.7 14.7 5.4 6.2 14.7 1.3 1 0 0 1 1 1 0 NOA36 protein Neur_chan_memb PF02932.16 EMC89624.1 - 4.5 7.3 4.7 5.3 7.0 4.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 EMC89624.1 - 8.5 5.5 8.9 9.9 5.3 8.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter PI3K_1B_p101 PF10486.9 EMC89624.1 - 9.4 3.9 10.9 12 3.5 10.9 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit LysM PF01476.20 EMC89625.1 - 2.9e-05 24.0 0.0 7.1e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 LysM domain YqhR PF11085.8 EMC89625.1 - 0.046 13.6 0.2 0.066 13.1 0.2 1.2 1 0 0 1 1 1 0 Conserved membrane protein YqhR Calx-beta PF03160.14 EMC89626.1 - 1.8e-241 782.2 93.4 6.5e-16 58.3 0.0 37.7 38 0 0 38 38 38 32 Calx-beta domain Laminin_G_3 PF13385.6 EMC89626.1 - 1.4e-19 70.7 0.1 4e-19 69.3 0.1 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily 7tm_2 PF00002.24 EMC89626.1 - 8.1e-13 48.2 24.4 1.4e-12 47.4 24.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) EPTP PF03736.17 EMC89626.1 - 2.4e-10 40.2 9.0 0.0021 18.0 0.3 5.7 6 0 0 6 6 6 3 EPTP domain GPS PF01825.21 EMC89626.1 - 0.024 15.2 4.6 0.018 15.6 2.6 1.9 2 0 0 2 2 2 0 GPCR proteolysis site, GPS, motif DUF2207 PF09972.9 EMC89626.1 - 0.35 9.6 6.0 4.1 6.0 2.0 2.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Arrestin_N PF00339.29 EMC89627.1 - 1.9e-36 125.3 0.1 6.8e-35 120.3 0.1 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EMC89627.1 - 4e-25 88.8 0.0 3.1e-21 76.2 0.0 2.2 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Vps26 PF03643.15 EMC89627.1 - 0.0022 17.0 0.1 0.015 14.3 0.1 2.1 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Yae1_N PF09811.9 EMC89628.1 - 6.4e-13 48.2 54.3 2.5e+02 1.5 0.6 5.4 2 1 0 2 2 2 0 Essential protein Yae1, N terminal zf-C4 PF00105.18 EMC89629.1 - 1.5e-32 111.9 17.1 1.6e-32 111.8 17.1 1.0 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Peptidase_C98 PF15499.6 EMC89629.1 - 0.29 10.6 4.0 0.33 10.4 4.0 1.0 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Arb2 PF09757.9 EMC89631.1 - 3.1e-10 39.6 0.4 1.6e-06 27.5 0.1 2.1 2 0 0 2 2 2 2 Arb2 domain Hydrolase_4 PF12146.8 EMC89631.1 - 0.0027 17.0 0.0 0.0048 16.2 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF4495 PF14906.6 EMC89632.1 - 2.4e-138 460.5 15.3 2.4e-138 460.5 15.3 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4495) HAD_SAK_1 PF10307.9 EMC89632.1 - 0.049 13.4 0.1 0.14 11.9 0.1 1.7 1 0 0 1 1 1 0 HAD domain family 1 in Swiss Army Knife RNA repair proteins RTT107_BRCT_5 PF16770.5 EMC89633.1 - 4.5e-10 39.3 0.2 8.8e-10 38.4 0.2 1.5 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.5 EMC89633.1 - 0.00089 19.5 0.0 1.3 9.4 0.0 2.3 2 0 0 2 2 2 2 DNA ligase 3 BRCT domain BRCT PF00533.26 EMC89633.1 - 0.0033 17.8 0.8 0.076 13.4 0.5 2.3 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Ank_3 PF13606.6 EMC89634.1 - 4.1e-18 63.6 0.3 7.9e-06 25.8 0.0 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.7 EMC89634.1 - 1.3e-16 60.9 0.0 1.1e-15 58.0 0.0 2.2 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EMC89634.1 - 5.7e-15 55.0 0.6 0.00019 21.7 0.2 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 EMC89634.1 - 3.7e-14 52.9 0.9 3.2e-08 33.9 0.0 2.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC89634.1 - 6.8e-12 45.4 0.4 0.00051 20.3 0.0 4.2 2 1 2 4 4 4 3 Ankyrin repeats (many copies) C2 PF00168.30 EMC89635.1 - 1.4e-74 246.9 0.0 1.2e-25 89.7 0.0 3.3 3 0 0 3 3 3 3 C2 domain PRT_C PF08372.10 EMC89635.1 - 5.5e-07 29.5 3.6 3.5e-06 26.9 0.1 2.3 1 1 1 2 2 2 1 Plant phosphoribosyltransferase C-terminal Pex24p PF06398.11 EMC89635.1 - 6.8e-05 22.0 2.2 0.00012 21.2 2.2 1.3 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin CEP76-C2 PF15627.6 EMC89635.1 - 0.0015 18.1 0.0 0.15 11.6 0.0 2.7 3 0 0 3 3 3 1 CEP76 C2 domain 2OG-FeII_Oxy_4 PF13661.6 EMC89635.1 - 0.014 16.0 0.0 0.047 14.4 0.0 1.9 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Tom22 PF04281.13 EMC89635.1 - 0.036 13.9 0.0 0.089 12.6 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 DUF639 PF04842.12 EMC89635.1 - 0.084 12.3 0.9 0.3 10.5 0.9 1.7 1 1 0 1 1 1 0 Plant protein of unknown function (DUF639) E7 PF00527.18 EMC89635.1 - 0.18 12.1 0.3 0.42 10.8 0.3 1.6 1 0 0 1 1 1 0 E7 protein, Early protein COG5 PF10392.9 EMC89636.1 - 0.0019 18.4 18.3 0.022 14.9 0.2 3.4 1 1 2 3 3 3 2 Golgi transport complex subunit 5 TrbI_Ftype PF09677.10 EMC89636.1 - 0.44 10.9 4.1 3.4 8.0 0.5 2.6 2 0 0 2 2 2 0 Type-F conjugative transfer system protein (TrbI_Ftype) Baculo_PEP_C PF04513.12 EMC89636.1 - 0.62 10.1 13.9 4.9 7.2 0.2 3.6 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPR_19 PF14559.6 EMC89637.1 - 1.3e-37 128.1 44.5 0.0025 18.3 0.0 16.7 15 2 2 18 18 17 10 Tetratricopeptide repeat TPR_1 PF00515.28 EMC89637.1 - 1e-36 123.2 85.6 5.7e-05 22.8 0.0 23.5 27 1 0 28 28 22 10 Tetratricopeptide repeat TPR_2 PF07719.17 EMC89637.1 - 2.8e-34 114.4 88.6 0.00057 19.8 0.4 25.4 26 1 0 27 27 24 9 Tetratricopeptide repeat TPR_14 PF13428.6 EMC89637.1 - 1.2e-31 106.6 47.0 0.00081 20.0 0.7 21.6 16 6 8 24 24 20 6 Tetratricopeptide repeat TPR_16 PF13432.6 EMC89637.1 - 3.2e-31 107.7 35.4 3.6e-06 27.5 0.1 14.6 14 3 4 18 18 16 8 Tetratricopeptide repeat TPR_17 PF13431.6 EMC89637.1 - 5.2e-24 82.9 42.0 0.0043 17.3 0.0 19.0 19 1 1 20 20 19 4 Tetratricopeptide repeat TPR_8 PF13181.6 EMC89637.1 - 5.1e-22 76.2 73.1 0.0022 18.1 0.1 21.7 24 0 0 24 24 22 7 Tetratricopeptide repeat TPR_12 PF13424.6 EMC89637.1 - 6.8e-22 77.6 55.9 0.0012 19.0 0.2 15.7 13 5 5 18 18 16 8 Tetratricopeptide repeat TPR_11 PF13414.6 EMC89637.1 - 2.5e-21 75.1 60.9 0.0034 17.1 0.2 18.1 18 3 3 21 21 18 7 TPR repeat TPR_9 PF13371.6 EMC89637.1 - 2.5e-11 43.6 9.5 0.0095 16.1 0.0 8.7 7 2 1 8 8 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC89637.1 - 1.8e-09 37.7 38.7 0.0018 18.4 0.1 10.0 9 2 0 9 9 8 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EMC89637.1 - 1.9e-09 37.5 31.6 3.4 8.5 0.1 16.5 16 0 0 16 16 15 1 Tetratricopeptide repeat TPR_7 PF13176.6 EMC89637.1 - 1.1e-08 34.5 34.2 0.57 10.3 0.1 15.3 18 0 0 18 18 17 1 Tetratricopeptide repeat TPR_15 PF13429.6 EMC89637.1 - 1.3e-05 24.5 53.1 2.3e-05 23.8 4.8 8.2 6 2 3 9 9 9 3 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 EMC89637.1 - 8.2e-05 21.8 3.1 0.019 14.0 0.0 3.5 3 0 0 3 3 3 2 Coatomer WD associated region DUF928 PF06051.12 EMC89637.1 - 0.0017 18.3 1.2 0.026 14.4 0.6 2.7 2 0 0 2 2 2 1 Domain of Unknown Function (DUF928) TolB_N PF04052.13 EMC89637.1 - 0.015 15.5 0.1 0.098 12.8 0.0 2.3 2 0 0 2 2 2 0 TolB amino-terminal domain TPR_10 PF13374.6 EMC89637.1 - 0.026 14.4 19.7 25 4.9 0.0 10.7 11 0 0 11 11 10 0 Tetratricopeptide repeat DUF3856 PF12968.7 EMC89637.1 - 0.048 13.7 5.7 14 5.7 0.0 5.6 4 2 0 4 4 4 0 Domain of Unknown Function (DUF3856) DUF4375 PF14300.6 EMC89637.1 - 0.082 13.2 3.0 15 5.9 0.8 4.6 2 1 2 4 4 4 0 Domain of unknown function (DUF4375) DUF982 PF06169.12 EMC89637.1 - 0.15 12.1 1.5 2.5 8.2 0.2 3.8 2 1 1 3 3 3 0 Protein of unknown function (DUF982) GP3_package PF16677.5 EMC89637.1 - 0.16 12.1 1.4 0.74 10.0 0.0 2.9 3 0 0 3 3 1 0 DNA-packaging protein gp3 BTAD PF03704.17 EMC89637.1 - 0.17 12.3 0.0 0.17 12.3 0.0 5.3 5 1 0 5 5 5 0 Bacterial transcriptional activator domain Alkyl_sulf_dimr PF14863.6 EMC89637.1 - 0.33 11.4 10.2 35 4.8 0.1 4.8 2 2 0 2 2 2 0 Alkyl sulfatase dimerisation FlbT PF07378.11 EMC89637.1 - 0.53 10.4 5.0 1.8 8.7 0.7 3.9 3 0 0 3 3 3 0 Flagellar protein FlbT TPR_20 PF14561.6 EMC89637.1 - 0.69 10.3 0.0 0.69 10.3 0.0 8.8 12 1 1 13 13 8 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMC89637.1 - 2.1 8.5 17.5 0.1 12.7 0.5 6.1 7 0 0 7 7 5 0 Fis1 C-terminal tetratricopeptide repeat HemY_N PF07219.13 EMC89637.1 - 3.2 8.0 9.7 87 3.4 0.1 5.7 6 0 0 6 6 5 0 HemY protein N-terminus TPR_5 PF12688.7 EMC89637.1 - 8 6.7 10.5 1.2 9.4 0.0 4.7 5 1 1 6 6 5 0 Tetratrico peptide repeat Sulfatase PF00884.23 EMC89638.1 - 3.9e-43 148.0 0.1 7.4e-43 147.1 0.1 1.4 1 0 0 1 1 1 1 Sulfatase DUF4976 PF16347.5 EMC89638.1 - 1.3e-05 25.4 0.0 7.6e-05 22.9 0.0 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4976) DUF4994 PF16385.5 EMC89638.1 - 3.4e-05 23.7 0.6 0.0009 19.1 0.0 2.7 2 1 0 2 2 2 1 Domain of unknown function Metalloenzyme PF01676.18 EMC89638.1 - 4.6e-05 22.9 0.0 7.7e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily DUF229 PF02995.17 EMC89638.1 - 0.00011 21.0 0.0 0.00021 20.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Phosphodiest PF01663.22 EMC89638.1 - 0.0055 16.3 4.2 0.013 15.1 1.6 2.7 2 1 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF1501 PF07394.12 EMC89638.1 - 0.064 12.3 0.0 0.093 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) COX_ARM PF06481.14 EMC89638.1 - 0.18 11.7 1.4 0.2 11.6 0.2 1.7 2 0 0 2 2 2 0 COX Aromatic Rich Motif Rieske_2 PF13806.6 EMC89639.1 - 8.1e-11 41.8 0.0 1.1e-10 41.4 0.0 1.1 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Rieske PF00355.26 EMC89639.1 - 1.7e-10 40.7 0.0 2.6e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain BTB PF00651.31 EMC89640.1 - 8.8e-26 90.3 2.0 4.4e-18 65.5 0.4 3.5 3 0 0 3 3 3 2 BTB/POZ domain Ras PF00071.22 EMC89640.1 - 5.1e-06 26.2 0.0 1.1e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Ras family dUTPase_2 PF08761.11 EMC89640.1 - 0.075 13.2 0.0 0.28 11.4 0.0 1.9 2 0 0 2 2 2 0 dUTPase ELL PF10390.9 EMC89641.1 - 1.2e-87 294.0 0.0 1.2e-87 294.0 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase II elongation factor ELL Occludin_ELL PF07303.13 EMC89641.1 - 4.3e-31 107.6 11.3 4.3e-31 107.6 11.3 3.2 3 0 0 3 3 3 1 Occludin homology domain Pox_Ag35 PF03286.14 EMC89641.1 - 0.41 10.4 9.6 1.1 9.0 9.6 1.7 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF1925 PF09094.11 EMC89641.1 - 3.8 7.9 6.1 1.1 9.6 1.5 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF1925) Proho_convert PF12177.8 EMC89642.1 - 3.1e-23 81.4 2.5 3.1e-23 81.4 2.5 1.6 2 0 0 2 2 2 1 Prohormone convertase enzyme TrmB PF01978.19 EMC89642.1 - 0.09 12.7 0.1 0.12 12.2 0.1 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Peptidase_S8 PF00082.22 EMC89643.1 - 8.4e-52 176.3 3.0 1.1e-51 175.9 3.0 1.1 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 EMC89643.1 - 1.9e-26 91.9 0.2 3.7e-26 91.0 0.2 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain Peptidase_S8_N PF16361.5 EMC89643.1 - 0.035 14.6 2.2 0.094 13.2 2.2 1.7 1 0 0 1 1 1 0 N-terminal of Subtilase family Calpain_inhib PF00748.19 EMC89644.1 - 2.8e-117 387.3 92.5 7.3e-36 123.7 18.3 6.1 5 1 1 6 6 6 5 Calpain inhibitor Peptidase_M1 PF01433.20 EMC89645.1 - 3.4e-81 272.0 0.5 9.1e-81 270.6 0.2 1.8 2 0 0 2 2 2 1 Peptidase family M1 domain ERAP1_C PF11838.8 EMC89645.1 - 1e-71 242.1 0.1 1.8e-71 241.3 0.1 1.4 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EMC89645.1 - 3.1e-25 89.5 0.6 5.5e-25 88.6 0.2 1.6 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain DUF1077 PF06417.12 EMC89646.1 - 7.4e-13 48.6 0.0 8e-13 48.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) tRNA_m1G_MT PF01746.21 EMC89647.1 - 7.1e-22 78.1 0.0 8.4e-22 77.8 0.0 1.0 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase DUF543 PF04418.12 EMC89647.1 - 0.0012 18.8 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF543) RNA_pol_I_A49 PF06870.12 EMC89648.1 - 2.2e-87 293.5 3.3 2.8e-73 247.0 2.4 1.9 2 0 0 2 2 2 2 A49-like RNA polymerase I associated factor DUF1638 PF07796.11 EMC89648.1 - 0.086 12.9 0.2 0.23 11.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1638) PT PF04886.12 EMC89649.1 - 0.00022 20.7 51.6 1.8 8.2 5.5 8.2 4 3 0 4 4 4 3 PT repeat zf-CCHC PF00098.23 EMC89650.1 - 7.5e-08 32.1 13.2 2.1e-05 24.4 1.9 5.1 5 0 0 5 5 5 3 Zinc knuckle zf-CCHC_3 PF13917.6 EMC89650.1 - 0.0026 17.7 0.9 0.0026 17.7 0.9 4.2 3 1 1 4 4 4 2 Zinc knuckle zf-CCHC_2 PF13696.6 EMC89650.1 - 0.011 15.6 2.5 0.011 15.6 2.5 5.1 5 0 0 5 5 5 0 Zinc knuckle zf-CCHC_4 PF14392.6 EMC89650.1 - 0.13 12.0 0.1 0.13 12.0 0.1 4.2 4 0 0 4 4 4 0 Zinc knuckle CDC27 PF09507.10 EMC89651.1 - 0.2 11.0 33.7 0.31 10.4 33.7 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 PAX PF00292.18 EMC89652.1 - 9.9e-76 251.7 0.7 1.6e-75 251.0 0.7 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_32 PF13565.6 EMC89652.1 - 9.8e-07 29.3 0.2 0.0013 19.3 0.0 2.4 1 1 1 2 2 2 2 Homeodomain-like domain HTH_23 PF13384.6 EMC89652.1 - 2.2e-05 24.1 0.0 5e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 EMC89652.1 - 0.016 15.3 0.0 0.034 14.3 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_IS1 PF12759.7 EMC89652.1 - 0.03 13.9 0.1 0.11 12.1 0.0 2.0 2 0 0 2 2 2 0 InsA C-terminal domain Homeodomain PF00046.29 EMC89652.1 - 0.06 13.2 0.1 0.17 11.7 0.1 1.8 1 0 0 1 1 1 0 Homeodomain Ribosomal_S13_N PF08069.12 EMC89652.1 - 0.087 12.9 0.1 0.38 10.8 0.0 2.0 2 0 0 2 2 2 0 Ribosomal S13/S15 N-terminal domain HTH_38 PF13936.6 EMC89652.1 - 0.5 10.2 0.1 0.5 10.2 0.1 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain Lig_chan PF00060.26 EMC89653.1 - 1.7e-55 187.0 0.2 2.4e-55 186.5 0.2 1.2 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 EMC89653.1 - 6.3e-47 158.5 0.0 2.7e-46 156.5 0.0 2.1 3 0 0 3 3 3 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 EMC89653.1 - 4.1e-18 65.6 0.0 7.2e-18 64.8 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 ANF_receptor PF01094.28 EMC89653.1 - 1.8e-15 56.9 0.0 3e-15 56.2 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region MSSP PF03940.13 EMC89654.1 - 0.064 12.9 1.2 3.2 7.4 1.2 2.8 1 1 0 1 1 1 0 Male specific sperm protein Pkinase PF00069.25 EMC89655.1 - 5.7e-74 248.8 0.0 7.3e-74 248.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC89655.1 - 1.6e-30 106.3 0.0 2.1e-30 105.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMC89655.1 - 0.00086 18.7 0.1 0.0015 18.0 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Malic_M PF03949.15 EMC89656.1 - 3.4e-97 324.7 0.2 4.4e-97 324.4 0.2 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EMC89656.1 - 1.3e-79 266.3 0.0 2.3e-79 265.5 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Pol_alpha_B_N PF08418.10 EMC89656.1 - 0.047 13.6 0.1 0.082 12.9 0.1 1.3 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Lactamase_B PF00753.27 EMC89657.1 - 4.1e-12 46.5 0.0 4.8e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.6 EMC89657.1 - 1.8e-07 30.7 0.0 3.3e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 EMC89657.1 - 1.1e-05 25.1 0.0 1.3e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain PDEase_II PF02112.15 EMC89657.1 - 0.24 10.5 0.0 0.34 10.0 0.0 1.1 1 0 0 1 1 1 0 cAMP phosphodiesterases class-II KH_1 PF00013.29 EMC89659.1 - 8.5e-22 76.8 0.6 3.2e-14 52.5 0.1 2.3 2 0 0 2 2 2 2 KH domain zf-C3HC4_3 PF13920.6 EMC89659.1 - 1.8e-06 27.7 7.9 2.6e-06 27.2 7.9 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC89659.1 - 0.0021 17.9 4.9 0.0038 17.1 4.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EMC89659.1 - 0.059 13.4 3.7 0.11 12.5 3.7 1.5 1 0 0 1 1 1 0 RING-type zinc-finger KH_2 PF07650.17 EMC89659.1 - 0.11 12.3 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 KH domain zf-RING_5 PF14634.6 EMC89659.1 - 0.23 11.4 3.2 0.47 10.5 3.2 1.4 1 0 0 1 1 1 0 zinc-RING finger domain DUF4050 PF13259.6 EMC89660.1 - 0.13 12.6 19.4 7.7 6.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) DDHD PF02862.17 EMC89660.1 - 0.2 11.8 6.1 0.39 10.8 6.1 1.5 1 0 0 1 1 1 0 DDHD domain Dsh_C PF12316.8 EMC89660.1 - 0.45 10.9 8.3 1.3 9.4 8.3 1.7 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Vfa1 PF08432.10 EMC89660.1 - 0.86 9.9 25.5 1.5 9.2 25.5 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CDC45 PF02724.14 EMC89660.1 - 1.7 6.9 22.8 2.4 6.3 22.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 EMC89660.1 - 1.9 7.6 7.4 2.8 7.1 7.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 EMC89660.1 - 2.8 6.6 19.5 4.1 6.1 19.5 1.1 1 0 0 1 1 1 0 Presenilin UPF0560 PF10577.9 EMC89660.1 - 6.6 5.1 16.0 9.5 4.6 16.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Endostatin PF06482.11 EMC89660.1 - 9.3 5.6 12.6 18 4.7 12.6 1.4 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Neogenin_C PF06583.12 EMC89661.1 - 7.8e-33 114.6 0.1 7.9e-33 114.5 0.1 1.0 1 0 0 1 1 1 1 Neogenin C-terminus MBD_C PF14048.6 EMC89662.1 - 1.1e-34 119.0 0.2 1.3e-34 118.7 0.2 1.1 1 0 0 1 1 1 1 C-terminal domain of methyl-CpG binding protein 2 and 3 MBDa PF16564.5 EMC89662.1 - 0.036 14.3 1.5 0.041 14.1 0.1 1.7 2 0 0 2 2 2 0 p55-binding region of Methyl-CpG-binding domain proteins MBD Pardaxin PF07425.11 EMC89662.1 - 0.058 13.0 0.9 0.15 11.7 0.9 1.7 1 0 0 1 1 1 0 Pardaxin Fe-ADH PF00465.19 EMC89662.1 - 0.061 12.1 0.0 1.6 7.5 0.0 2.0 1 1 1 2 2 2 0 Iron-containing alcohol dehydrogenase IMS PF00817.20 EMC89663.1 - 3.9e-45 153.5 0.0 7.1e-45 152.7 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 EMC89663.1 - 2.5e-14 54.0 0.0 1.3e-13 51.6 0.0 2.3 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 EMC89663.1 - 6.5e-06 26.2 0.0 2.4e-05 24.4 0.0 2.1 1 0 0 1 1 1 1 IMS family HHH motif DNA_pol_lambd_f PF10391.9 EMC89663.1 - 0.0001 22.0 0.0 0.00045 20.0 0.0 2.1 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda UBM PF14377.6 EMC89663.1 - 0.00025 20.4 3.9 0.006 16.0 1.1 3.2 3 0 0 3 3 3 1 Ubiquitin binding region Cdd1 PF11731.8 EMC89663.1 - 0.00029 21.0 0.0 0.00082 19.6 0.0 1.7 1 0 0 1 1 1 1 Pathogenicity locus HHH_5 PF14520.6 EMC89663.1 - 0.002 18.7 0.2 0.0093 16.6 0.1 1.8 1 1 0 1 1 1 1 Helix-hairpin-helix domain HHH PF00633.23 EMC89663.1 - 0.0075 16.1 0.0 0.017 14.9 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_8 PF14716.6 EMC89663.1 - 0.16 12.3 0.0 0.7 10.3 0.0 2.2 1 0 0 1 1 1 0 Helix-hairpin-helix domain START PF01852.19 EMC89664.1 - 3.9e-24 85.2 0.0 4.6e-24 85.0 0.0 1.0 1 0 0 1 1 1 1 START domain LAS2 PF15792.5 EMC89665.1 - 0.0011 19.5 0.2 0.004 17.6 0.0 2.1 2 0 0 2 2 2 1 Lung adenoma susceptibility protein 2 Ras PF00071.22 EMC89666.1 - 3.1e-54 182.9 0.0 3.7e-54 182.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC89666.1 - 2e-32 111.9 0.0 2.8e-32 111.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC89666.1 - 9.7e-13 47.9 0.0 1.5e-12 47.3 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EMC89666.1 - 0.00024 21.0 0.1 0.25 11.2 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EMC89666.1 - 0.00037 20.6 0.0 0.00067 19.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC89666.1 - 0.0072 15.9 0.0 0.044 13.3 0.0 2.2 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 EMC89666.1 - 0.008 15.9 0.0 0.055 13.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain ATP_bind_1 PF03029.17 EMC89666.1 - 0.0087 15.9 0.3 0.17 11.6 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein Gtr1_RagA PF04670.12 EMC89666.1 - 0.063 12.6 0.1 0.15 11.4 0.1 1.7 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EMC89666.1 - 0.067 12.3 0.2 5.4 6.1 0.1 2.3 1 1 1 2 2 2 0 G-protein alpha subunit CENP-M PF11111.8 EMC89666.1 - 0.11 11.7 0.0 0.15 11.2 0.0 1.1 1 0 0 1 1 1 0 Centromere protein M (CENP-M) AAA_22 PF13401.6 EMC89666.1 - 0.12 12.7 0.0 0.18 12.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain ATG16 PF08614.11 EMC89667.1 - 0.0029 17.9 9.6 0.0029 17.9 9.6 2.8 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) Cnn_1N PF07989.11 EMC89667.1 - 0.012 15.8 5.2 0.012 15.8 5.2 3.8 1 1 2 3 3 3 0 Centrosomin N-terminal motif 1 GAS PF13851.6 EMC89667.1 - 0.016 14.5 5.0 0.016 14.5 5.0 3.0 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Lebercilin PF15619.6 EMC89667.1 - 0.02 14.6 8.0 0.02 14.6 8.0 3.1 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Tcell_CD4_C PF12104.8 EMC89667.1 - 0.046 13.6 2.0 0.18 11.7 2.0 2.0 1 0 0 1 1 1 0 T cell CD4 receptor C terminal region MAD PF05557.13 EMC89667.1 - 0.053 11.9 37.3 0.015 13.7 32.3 1.9 1 1 1 2 2 2 0 Mitotic checkpoint protein Spc7 PF08317.11 EMC89667.1 - 0.1 11.5 32.1 0.22 10.4 23.1 2.6 2 1 1 3 3 3 0 Spc7 kinetochore protein DUF812 PF05667.11 EMC89667.1 - 0.24 10.2 25.8 0.3 9.9 25.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF3584 PF12128.8 EMC89667.1 - 0.78 7.2 34.5 0.24 8.9 29.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) NPV_P10 PF05531.12 EMC89667.1 - 1.6 9.2 6.6 0.73 10.3 0.9 3.0 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF4472 PF14739.6 EMC89667.1 - 1.7 9.4 32.6 2.3 9.0 15.2 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) Csm1_N PF18504.1 EMC89667.1 - 3.1 8.2 29.3 0.18 12.2 1.8 4.5 1 1 4 5 5 5 0 Csm1 N-terminal domain USP7_C2 PF14533.6 EMC89667.1 - 6.8 6.3 12.2 2.8 7.6 2.7 2.5 1 1 1 2 2 2 0 Ubiquitin-specific protease C-terminal Fib_alpha PF08702.10 EMC89667.1 - 7.3 6.8 30.5 0.72 10.0 12.5 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Fez1 PF06818.15 EMC89667.1 - 9.2 6.7 34.3 3.1 8.2 26.6 2.3 1 1 1 2 2 2 0 Fez1 Collagen PF01391.18 EMC89669.1 - 2e-06 27.5 32.1 8.1e+02 -0.1 32.1 3.6 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) AcylCoA_DH_N PF12418.8 EMC89669.1 - 0.21 11.7 0.0 18 5.5 0.0 2.7 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase N terminal PITH PF06201.13 EMC89670.1 - 4.2e-40 137.4 0.0 5.8e-40 137.0 0.0 1.2 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.20 EMC89670.1 - 1.2e-13 51.0 0.0 2e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 EMC89670.1 - 0.0079 15.6 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Sad1_UNC PF07738.13 EMC89670.1 - 0.014 15.4 0.0 0.026 14.6 0.0 1.5 1 1 0 1 1 1 0 Sad1 / UNC-like C-terminal Glyco_transf_29 PF00777.18 EMC89671.1 - 5.2e-75 252.3 0.1 6.3e-75 252.0 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Homeodomain PF00046.29 EMC89673.1 - 1.6e-11 43.9 1.2 2.3e-11 43.4 1.2 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC89673.1 - 1.5e-05 24.8 0.4 2.9e-05 23.9 0.1 1.6 2 0 0 2 2 2 1 Homeobox KN domain HOCHOB PF17943.1 EMC89673.1 - 0.032 14.9 0.1 0.049 14.3 0.1 1.2 1 0 0 1 1 1 0 Homeobox-cysteine loop-homeobox PH_3 PF14593.6 EMC89673.1 - 0.065 13.4 0.6 0.08 13.1 0.6 1.1 1 0 0 1 1 1 0 PH domain Ferrochelatase PF00762.19 EMC89674.1 - 2.9e-111 371.6 0.0 3.3e-111 371.4 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase tRNA-synt_2 PF00152.20 EMC89675.1 - 6.4e-111 370.4 0.0 9.7e-111 369.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EMC89675.1 - 1.1e-11 44.6 0.0 1.9e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Maff2 PF12750.7 EMC89675.1 - 0.037 13.9 0.0 3.4 7.5 0.0 2.4 2 0 0 2 2 2 0 Maff2 family DUF1565 PF07602.11 EMC89675.1 - 0.065 12.6 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1565) tRNA_anti-like PF12869.7 EMC89675.1 - 0.083 12.5 0.0 0.23 11.1 0.0 1.7 1 1 0 1 1 1 0 tRNA_anti-like tRNA-synt_2d PF01409.20 EMC89675.1 - 0.12 11.8 0.1 4.7 6.6 0.0 2.6 3 0 0 3 3 3 0 tRNA synthetases class II core domain (F) WW PF00397.26 EMC89676.1 - 2.2e-51 171.6 27.7 5.8e-13 48.7 2.9 5.3 5 0 0 5 5 5 4 WW domain C2 PF00168.30 EMC89676.1 - 8.6e-26 90.2 0.0 2.3e-25 88.9 0.0 1.7 1 0 0 1 1 1 1 C2 domain HECT PF00632.25 EMC89676.1 - 5.6e-16 58.9 0.0 7.6e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Gag_p30 PF02093.16 EMC89677.1 - 2.7e-17 63.0 0.0 3e-17 62.8 0.0 1.0 1 0 0 1 1 1 1 Gag P30 core shell protein ANF_receptor PF01094.28 EMC89678.1 - 4.8e-16 58.8 0.0 5.5e-16 58.6 0.0 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.6 EMC89678.1 - 0.11 12.1 0.0 0.13 11.9 0.0 1.0 1 0 0 1 1 1 0 Periplasmic binding protein TMEM72 PF16054.5 EMC89680.1 - 8.3e-81 270.0 0.7 9.9e-81 269.8 0.7 1.1 1 0 0 1 1 1 1 Transmembrane protein family 72 Cytochrom_B_N_2 PF13631.6 EMC89680.1 - 0.047 13.7 0.7 0.069 13.2 0.1 1.6 2 0 0 2 2 2 0 Cytochrome b(N-terminal)/b6/petB Abhydrolase_1 PF00561.20 EMC89681.1 - 2.6e-29 102.6 0.1 3.1e-29 102.4 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 EMC89681.1 - 9.5e-21 73.1 0.1 2.4e-20 71.9 0.0 1.7 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 EMC89681.1 - 5.2e-05 22.6 0.0 0.00089 18.6 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DLH PF01738.18 EMC89681.1 - 0.076 12.5 0.0 0.16 11.5 0.0 1.5 2 0 0 2 2 2 0 Dienelactone hydrolase family FSH1 PF03959.13 EMC89681.1 - 0.13 11.9 0.2 0.39 10.3 0.0 1.8 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Cutinase PF01083.22 EMC89681.1 - 0.16 11.9 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Cutinase Abhydrolase_1 PF00561.20 EMC89682.1 - 2.2e-24 86.5 0.2 3e-24 86.1 0.2 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 EMC89682.1 - 2.4e-15 55.9 0.7 1.5e-14 53.3 0.5 2.5 2 1 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 EMC89682.1 - 0.011 15.0 0.0 1.9 7.7 0.0 2.3 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Ank_2 PF12796.7 EMC89683.1 - 5.1e-26 91.1 1.8 2.2e-12 47.4 0.2 2.3 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC89683.1 - 7.1e-26 90.2 3.1 1.9e-08 34.7 0.1 4.1 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC89683.1 - 5.2e-25 87.2 3.2 4.8e-12 45.9 0.1 3.6 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EMC89683.1 - 1.3e-22 79.2 3.0 3.9e-06 27.1 0.0 5.7 5 1 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 EMC89683.1 - 7e-18 62.9 3.7 0.00024 21.3 0.0 6.1 6 0 0 6 6 6 3 Ankyrin repeat YfmQ PF10787.9 EMC89683.1 - 0.091 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein from bacillus cereus group UPF0542 PF15086.6 EMC89683.1 - 0.31 11.0 1.7 0.51 10.3 1.2 1.6 1 1 0 1 1 1 0 Uncharacterised protein family UPF0542 DUF3447 PF11929.8 EMC89683.1 - 0.4 10.7 3.3 1.7 8.7 0.3 2.7 2 1 0 3 3 3 0 Domain of unknown function (DUF3447) RVT_1 PF00078.27 EMC89684.1 - 0.00082 19.0 0.0 0.0033 16.9 0.0 1.8 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Abhydrolase_1 PF00561.20 EMC89685.1 - 7.7e-19 68.3 0.2 2.1e-18 66.9 0.2 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 EMC89685.1 - 0.016 14.8 0.0 0.033 13.7 0.0 1.6 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region BAAT_C PF08840.11 EMC89685.1 - 0.061 13.2 0.0 0.096 12.6 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Hydrolase_4 PF12146.8 EMC89685.1 - 0.069 12.4 0.0 0.83 8.9 0.0 2.1 1 1 0 1 1 1 0 Serine aminopeptidase, S33 DUF5034 PF16437.5 EMC89685.1 - 0.11 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5034) Abhydro_lipase PF04083.16 EMC89686.1 - 1.1e-20 72.9 0.0 2.5e-20 71.8 0.0 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 EMC89686.1 - 4.1e-19 69.2 0.1 2e-18 67.0 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF5034 PF16437.5 EMC89686.1 - 0.0019 18.2 0.0 0.006 16.6 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF5034) Hydrolase_4 PF12146.8 EMC89686.1 - 0.15 11.3 0.0 9.1 5.5 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 USP8_dimer PF08969.11 EMC89687.1 - 1.1e-18 67.5 0.1 1.1e-18 67.5 0.1 1.8 2 1 0 2 2 2 1 USP8 dimerisation domain JAB PF01398.21 EMC89687.1 - 1.7e-16 60.2 0.0 5e-16 58.7 0.0 1.8 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 EMC89687.1 - 1.3e-06 28.2 0.0 3.2e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain TPR_8 PF13181.6 EMC89687.1 - 0.066 13.5 0.0 0.19 12.0 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat ABC_tran_Xtn PF12848.7 EMC89687.1 - 4.8 7.3 15.6 2.8 8.0 13.6 1.6 2 0 0 2 2 2 0 ABC transporter Actin PF00022.19 EMC89688.1 - 7.6e-150 499.0 0.0 2.5e-149 497.3 0.0 1.7 1 1 0 1 1 1 1 Actin FA_hydroxylase PF04116.13 EMC89689.1 - 2.1e-23 83.1 18.8 2.1e-23 83.1 18.8 1.8 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily Abhydrolase_1 PF00561.20 EMC89690.1 - 2.7e-29 102.6 1.0 3.3e-29 102.3 1.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 EMC89690.1 - 1.4e-24 85.5 0.0 3e-24 84.4 0.0 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 EMC89690.1 - 6.6e-09 35.4 0.1 5.3e-06 25.9 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 FSH1 PF03959.13 EMC89690.1 - 0.0055 16.4 0.1 0.041 13.5 0.1 2.0 2 0 0 2 2 2 1 Serine hydrolase (FSH1) Lipase_3 PF01764.25 EMC89690.1 - 0.023 14.5 0.0 0.042 13.7 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF2974 PF11187.8 EMC89690.1 - 0.062 12.9 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_1 PF00561.20 EMC89691.1 - 3.2e-28 99.1 0.7 3.8e-28 98.8 0.7 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 EMC89691.1 - 1.4e-24 85.5 0.0 3e-24 84.4 0.0 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 EMC89691.1 - 1.3e-08 34.4 0.1 7.9e-06 25.3 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 FSH1 PF03959.13 EMC89691.1 - 0.0045 16.7 0.1 0.044 13.4 0.1 2.0 2 0 0 2 2 2 1 Serine hydrolase (FSH1) Lipase_3 PF01764.25 EMC89691.1 - 0.025 14.5 0.0 0.045 13.6 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF2974 PF11187.8 EMC89691.1 - 0.062 12.9 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) TPR_2 PF07719.17 EMC89692.1 - 5.4e-26 88.6 24.6 0.00021 21.2 0.7 9.7 10 0 0 10 10 9 5 Tetratricopeptide repeat TPR_1 PF00515.28 EMC89692.1 - 2.7e-24 83.9 17.8 3e-05 23.7 0.0 8.3 9 0 0 9 9 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 EMC89692.1 - 1.1e-22 78.3 24.3 0.0019 18.3 0.0 8.8 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_14 PF13428.6 EMC89692.1 - 7.6e-22 76.1 2.2 0.002 18.8 0.0 7.9 4 2 4 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.6 EMC89692.1 - 7.6e-18 64.8 5.7 0.00042 20.8 0.0 6.4 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 EMC89692.1 - 3.6e-16 59.2 15.6 0.00034 20.8 0.6 6.6 6 1 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 EMC89692.1 - 5.9e-15 54.7 18.8 0.0062 16.2 0.0 8.8 8 1 1 9 9 9 4 TPR repeat TPR_16 PF13432.6 EMC89692.1 - 2.6e-14 53.5 1.1 0.005 17.5 0.0 5.4 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 EMC89692.1 - 8e-14 50.9 12.5 0.13 12.7 0.4 8.2 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_10 PF13374.6 EMC89692.1 - 8.4e-12 44.6 11.5 0.045 13.6 0.1 7.8 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_6 PF13174.6 EMC89692.1 - 1.9e-10 40.7 9.9 0.36 11.6 0.5 7.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMC89692.1 - 3e-10 39.4 10.3 0.023 14.7 0.0 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_15 PF13429.6 EMC89692.1 - 3.5e-10 39.6 5.7 0.00016 21.0 0.1 5.0 2 2 2 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC89692.1 - 2.5e-07 30.8 13.7 0.81 10.0 0.1 5.9 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.8 EMC89692.1 - 1.1e-05 24.6 0.0 1.1e-05 24.6 0.0 4.2 3 1 2 5 5 5 1 NMDA receptor-regulated protein 1 TPR_MalT PF17874.1 EMC89692.1 - 3.2e-05 23.5 0.8 0.026 13.9 0.0 3.6 2 1 0 3 3 3 1 MalT-like TPR region TPR_9 PF13371.6 EMC89692.1 - 0.00034 20.7 0.1 29 4.9 0.0 5.1 5 1 0 5 5 5 0 Tetratricopeptide repeat DUF4810 PF16068.5 EMC89692.1 - 0.00042 20.8 10.4 0.25 11.9 0.5 4.6 4 1 0 4 4 4 2 Domain of unknown function (DUF4810) RPN7 PF10602.9 EMC89692.1 - 0.00064 19.5 10.8 0.16 11.6 0.9 5.1 4 1 1 5 5 5 1 26S proteasome subunit RPN7 DUF627 PF04781.12 EMC89692.1 - 0.01 15.8 2.9 0.24 11.4 0.0 3.8 4 1 1 5 5 4 0 Protein of unknown function (DUF627) MIT PF04212.18 EMC89692.1 - 0.012 15.7 8.4 33 4.6 0.0 6.2 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain SPOB_a PF14689.6 EMC89692.1 - 0.014 15.1 5.8 0.69 9.7 0.1 4.5 5 0 0 5 5 5 0 Sensor_kinase_SpoOB-type, alpha-helical domain TOM20_plant PF06552.12 EMC89692.1 - 0.015 15.1 5.6 11 5.7 0.0 4.6 3 2 2 6 6 6 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_20 PF14561.6 EMC89692.1 - 0.039 14.3 4.2 5 7.5 0.1 4.7 4 1 1 5 5 5 0 Tetratricopeptide repeat Orthopox_B11R PF07033.11 EMC89692.1 - 0.049 13.4 0.5 0.16 11.8 0.5 1.9 1 0 0 1 1 1 0 Orthopoxvirus B11R protein PPR PF01535.20 EMC89692.1 - 0.15 12.4 4.0 6.9 7.2 0.0 4.0 4 0 0 4 4 3 0 PPR repeat TPR_3 PF07720.12 EMC89692.1 - 0.35 10.9 9.4 7.4 6.7 1.0 4.0 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_21 PF09976.9 EMC89692.1 - 0.42 10.3 9.8 1.9 8.2 0.2 4.4 4 1 0 4 4 4 0 Tetratricopeptide repeat-like domain NSF PF02071.20 EMC89692.1 - 0.62 11.0 6.5 24 6.3 0.4 4.1 4 0 0 4 4 2 0 Aromatic-di-Alanine (AdAR) repeat ANAPC5 PF12862.7 EMC89692.1 - 0.66 10.1 7.5 0.13 12.3 1.3 3.3 4 1 1 5 5 3 0 Anaphase-promoting complex subunit 5 MAS20 PF02064.15 EMC89692.1 - 1.1 9.4 8.4 2.7 8.1 0.3 4.2 4 2 0 4 4 4 0 MAS20 protein import receptor Spore_III_AB PF09548.10 EMC89692.1 - 1.3 9.1 6.5 0.57 10.3 0.4 3.1 3 1 1 4 4 4 0 Stage III sporulation protein AB (spore_III_AB) MFS_1 PF07690.16 EMC89693.1 - 5.3e-38 130.9 42.8 1e-24 87.1 19.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EMC89693.1 - 0.0013 17.7 15.9 0.0023 16.9 3.6 3.2 2 1 0 2 2 2 1 MFS_1 like family Gate PF07670.14 EMC89693.1 - 1.4 9.2 10.0 1.5 9.2 2.4 3.1 2 2 0 2 2 2 0 Nucleoside recognition Fumble PF03630.14 EMC89694.1 - 6.8e-121 403.5 0.1 7.9e-121 403.3 0.1 1.0 1 0 0 1 1 1 1 Fumble SpoU_methylase PF00588.19 EMC89694.1 - 0.074 13.2 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 SpoU rRNA Methylase family Kinesin PF00225.23 EMC89695.1 - 5.8e-94 314.7 4.1 5.8e-94 314.7 4.1 4.2 4 0 0 4 4 4 1 Kinesin motor domain Microtub_bd PF16796.5 EMC89695.1 - 6e-15 55.5 0.1 6e-15 55.5 0.1 5.2 4 0 0 4 4 4 2 Microtubule binding DAPDH_C PF16654.5 EMC89695.1 - 3.7 7.4 7.8 0.43 10.4 1.3 2.8 2 0 0 2 2 2 0 Diaminopimelic acid dehydrogenase C-terminal domain YrzO PF14142.6 EMC89695.1 - 6.2 6.8 11.1 1.8 8.5 5.5 3.1 2 0 0 2 2 2 0 YrzO-like protein 7tm_1 PF00001.21 EMC89696.1 - 1e-73 247.9 11.9 1.3e-73 247.6 11.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC89696.1 - 2e-05 24.1 12.5 3.6e-05 23.3 12.5 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC89696.1 - 0.015 14.9 13.5 0.055 13.1 13.4 2.0 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx RNase_P_p30 PF01876.16 EMC89697.1 - 1e-62 211.4 0.0 1.2e-62 211.2 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit p30 PTS_EIIA_2 PF00359.22 EMC89697.1 - 0.018 15.0 0.0 4.5 7.2 0.0 2.3 2 0 0 2 2 2 0 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Ank_2 PF12796.7 EMC89698.1 - 6.1e-24 84.4 0.5 4.9e-13 49.5 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC89698.1 - 8.1e-21 73.8 0.2 6e-07 29.6 0.0 3.9 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EMC89698.1 - 2.7e-20 71.8 0.1 1e-06 28.9 0.0 3.9 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 EMC89698.1 - 4.4e-19 66.6 0.0 4.6e-06 26.6 0.0 4.4 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EMC89698.1 - 1.5e-18 66.9 0.0 2.1e-09 37.7 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Linker_histone PF00538.19 EMC89698.1 - 0.0013 19.0 0.5 0.99 9.8 0.0 3.0 3 0 0 3 3 3 2 linker histone H1 and H5 family HlyU PF10115.9 EMC89698.1 - 0.039 14.0 0.1 0.088 12.9 0.1 1.5 1 0 0 1 1 1 0 Transcriptional activator HlyU DUF4691 PF15762.5 EMC89698.1 - 0.15 12.2 4.7 0.24 11.5 4.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4691) RAWUL PF16207.5 EMC89699.1 - 4.9e-13 49.5 1.3 6.7e-12 45.9 0.0 2.9 3 0 0 3 3 3 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_2 PF13923.6 EMC89699.1 - 6.8e-10 38.6 10.8 6.8e-10 38.6 10.8 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC89699.1 - 6e-08 32.4 11.5 6e-08 32.4 11.5 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC89699.1 - 0.0001 22.2 11.3 0.0001 22.2 11.3 2.9 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EMC89699.1 - 0.00011 22.3 10.4 0.00011 22.3 10.4 3.2 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EMC89699.1 - 0.00014 22.1 9.6 0.00014 22.1 9.6 2.7 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.6 EMC89699.1 - 0.00048 20.0 11.2 0.00048 20.0 11.2 3.4 3 1 1 4 4 4 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EMC89699.1 - 0.0011 18.8 9.1 0.0011 18.8 9.1 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 EMC89699.1 - 0.0035 17.1 7.1 0.0065 16.3 7.1 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.5 EMC89699.1 - 0.004 17.3 5.3 0.004 17.3 5.3 2.7 3 0 0 3 3 3 1 zinc RING finger of MSL2 zf-rbx1 PF12678.7 EMC89699.1 - 0.015 15.6 8.4 0.076 13.3 8.4 2.2 1 1 0 1 1 1 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EMC89699.1 - 0.02 14.7 8.4 0.02 14.7 8.4 2.9 3 1 0 3 3 2 0 Prokaryotic RING finger family 4 DUF678 PF05077.12 EMC89699.1 - 0.18 11.9 3.4 1.6 9.0 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF678) zf-C3HC4_5 PF17121.5 EMC89699.1 - 0.42 10.5 7.3 1.5 8.8 7.3 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EMC89699.1 - 3.4 7.6 13.2 0.046 13.6 4.1 2.5 3 0 0 3 3 3 0 zf-RING of BARD1-type protein Zn_Tnp_IS1595 PF12760.7 EMC89699.1 - 8.4 6.5 12.5 3.4 7.7 0.2 3.0 2 1 1 3 3 3 0 Transposase zinc-ribbon domain CBM_21 PF03370.13 EMC89700.1 - 1e-33 115.9 2.3 1.5e-33 115.3 2.3 1.2 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 EMC89700.1 - 7.7e-16 58.5 1.6 1.5e-15 57.5 1.6 1.5 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) Ank_5 PF13857.6 EMC89701.1 - 3.3e-102 333.2 34.5 1.1e-13 51.1 0.2 13.9 5 5 8 13 13 13 13 Ankyrin repeats (many copies) Ank PF00023.30 EMC89701.1 - 7.2e-101 326.6 44.8 9.2e-08 32.2 0.2 18.0 18 0 0 18 18 18 15 Ankyrin repeat Ank_4 PF13637.6 EMC89701.1 - 8.3e-99 322.8 21.6 6.5e-13 48.9 0.2 13.7 6 5 7 14 14 14 14 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC89701.1 - 4.8e-98 321.9 30.3 6.9e-15 55.4 0.1 9.8 5 5 3 9 9 9 9 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC89701.1 - 6e-87 275.1 22.8 1.6e-06 28.0 0.1 17.8 18 0 0 18 18 18 14 Ankyrin repeat PARP PF00644.20 EMC89701.1 - 1e-25 90.5 4.1 3.1e-23 82.4 4.1 2.4 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain SAM_2 PF07647.17 EMC89701.1 - 1.2e-13 50.9 0.1 3.1e-13 49.6 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EMC89701.1 - 3.1e-11 43.6 0.1 7e-11 42.4 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Vps39_1 PF10366.9 EMC89701.1 - 0.0029 17.9 1.0 4.3 7.6 0.0 3.4 4 0 0 4 4 4 2 Vacuolar sorting protein 39 domain 1 ATP-grasp_4 PF13535.6 EMC89701.1 - 0.2 11.2 0.4 0.5 10.0 0.0 1.8 2 0 0 2 2 2 0 ATP-grasp domain 7tm_1 PF00001.21 EMC89702.1 - 9.3e-78 261.2 13.7 1.1e-77 260.9 13.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC89702.1 - 1.5e-09 37.6 10.8 5.8e-09 35.7 10.8 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC89702.1 - 2.5e-07 30.6 15.7 3.4e-07 30.2 8.0 2.3 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 EMC89702.1 - 0.0066 16.2 7.6 0.013 15.2 6.8 1.9 2 1 0 2 2 2 1 Olfactory receptor SARS_3b PF12383.8 EMC89702.1 - 0.06 13.5 0.4 0.2 11.8 0.0 1.9 2 0 0 2 2 2 0 Severe acute respiratory syndrome coronavirus 3b protein MTBP_C PF14920.6 EMC89702.1 - 0.067 12.9 0.8 0.13 12.0 0.8 1.4 1 0 0 1 1 1 0 MDM2-binding DUF621 PF04789.15 EMC89702.1 - 6.7 5.8 12.5 20 4.2 12.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF621) RabGAP-TBC PF00566.18 EMC89703.1 - 8.9e-50 169.3 0.0 1.7e-49 168.4 0.0 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain NOC3p PF07540.11 EMC89704.1 - 4.8e-30 103.9 1.7 4.8e-30 103.9 1.7 3.3 3 0 0 3 3 3 1 Nucleolar complex-associated protein CBF PF03914.17 EMC89704.1 - 4.9e-29 101.5 0.3 4.9e-29 101.5 0.3 2.6 2 1 0 2 2 2 1 CBF/Mak21 family RICTOR_N PF14664.6 EMC89704.1 - 0.26 10.2 9.2 0.78 8.7 0.7 3.1 2 1 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, N-term SCIMP PF15050.6 EMC89704.1 - 4.6 7.7 8.1 0.4 11.1 0.8 2.5 2 1 0 2 2 2 0 SCIMP protein PI-PLC-X PF00388.19 EMC89705.1 - 5.9e-60 201.1 0.0 1.5e-59 199.7 0.0 1.8 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EMC89705.1 - 2.5e-35 121.3 0.0 4.1e-33 114.2 0.0 3.1 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain RasGEF PF00617.19 EMC89705.1 - 5.5e-23 82.1 0.1 1.5e-22 80.7 0.1 1.8 1 0 0 1 1 1 1 RasGEF domain RA PF00788.23 EMC89705.1 - 1.6e-19 70.3 0.0 3.9e-17 62.7 0.1 2.6 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain C2 PF00168.30 EMC89705.1 - 3.9e-08 33.5 0.0 8.2e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 C2 domain PH_14 PF17787.1 EMC89705.1 - 0.0059 16.5 0.2 5.3 6.9 0.0 3.7 3 0 0 3 3 3 1 PH domain ADK PF00406.22 EMC89706.1 - 1e-21 77.6 0.9 2.3e-18 66.8 0.4 2.7 2 1 1 3 3 3 2 Adenylate kinase AAA_17 PF13207.6 EMC89706.1 - 6.1e-14 52.6 2.3 1e-08 35.7 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_18 PF13238.6 EMC89706.1 - 1.2e-08 35.6 0.7 0.00018 22.1 0.1 3.1 2 1 0 2 2 2 2 AAA domain Hydin_ADK PF17213.3 EMC89706.1 - 8.8e-08 32.7 0.2 0.0003 21.1 0.0 2.8 2 1 0 2 2 2 2 Hydin Adenylate kinase-like domain AAA PF00004.29 EMC89706.1 - 3.9e-06 27.3 0.0 0.075 13.5 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) SKI PF01202.22 EMC89706.1 - 7.4e-06 26.2 0.5 0.034 14.3 0.0 3.2 3 0 0 3 3 3 2 Shikimate kinase AAA_33 PF13671.6 EMC89706.1 - 3.6e-05 24.0 0.0 0.031 14.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EMC89706.1 - 0.00012 22.6 1.2 0.6 10.6 0.0 3.2 3 0 0 3 3 3 2 ABC transporter AAA_22 PF13401.6 EMC89706.1 - 0.00071 19.9 0.2 0.32 11.3 0.0 3.0 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 EMC89706.1 - 0.0009 19.2 0.0 0.0022 17.9 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_5 PF07728.14 EMC89706.1 - 0.0014 18.7 0.0 0.05 13.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) KTI12 PF08433.10 EMC89706.1 - 0.0025 17.3 0.8 1.4 8.3 0.0 2.9 3 0 0 3 3 3 2 Chromatin associated protein KTI12 AAA_16 PF13191.6 EMC89706.1 - 0.0025 18.2 0.0 0.63 10.4 0.0 3.0 3 0 0 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EMC89706.1 - 0.0029 17.4 0.0 0.9 9.3 0.0 3.0 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain Cytidylate_kin PF02224.18 EMC89706.1 - 0.027 14.2 0.0 13 5.4 0.0 3.1 2 1 1 3 3 3 0 Cytidylate kinase ZZ PF00569.17 EMC89706.1 - 0.03 14.1 0.1 0.059 13.2 0.1 1.4 1 0 0 1 1 1 0 Zinc finger, ZZ type RNA_helicase PF00910.22 EMC89706.1 - 0.031 14.7 0.2 11 6.5 0.0 3.2 3 0 0 3 3 3 0 RNA helicase Mg_chelatase PF01078.21 EMC89706.1 - 0.039 13.3 0.0 0.24 10.7 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 EMC89706.1 - 0.04 13.2 0.0 1 8.6 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin G-alpha PF00503.20 EMC89706.1 - 0.043 13.0 0.9 3.3 6.8 0.0 2.4 2 1 0 2 2 2 0 G-protein alpha subunit AAA_28 PF13521.6 EMC89706.1 - 0.052 13.8 2.4 5.1 7.3 0.0 3.0 3 0 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 EMC89706.1 - 0.093 12.6 0.1 18 5.2 0.0 2.8 2 1 0 2 2 2 0 NTPase MMR_HSR1 PF01926.23 EMC89706.1 - 0.097 12.8 0.0 5.7 7.0 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase zf-C2H2_4 PF13894.6 EMC89708.1 - 0.73 10.8 8.1 3.8 8.6 0.1 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-FCS PF06467.14 EMC89708.1 - 1.2 9.1 11.3 0.44 10.5 1.3 2.8 3 0 0 3 3 3 0 MYM-type Zinc finger with FCS sequence motif zf-C2H2 PF00096.26 EMC89708.1 - 2.9 8.5 7.5 17 6.1 0.2 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type Njmu-R1 PF15053.6 EMC89709.1 - 6.9e-170 564.8 1.3 7.7e-170 564.6 1.3 1.0 1 0 0 1 1 1 1 Mjmu-R1-like protein family Rhomboid PF01694.22 EMC89710.1 - 6.1e-34 117.2 11.7 6.1e-34 117.2 11.7 1.8 2 0 0 2 2 2 1 Rhomboid family EF-hand_7 PF13499.6 EMC89710.1 - 3.3e-09 37.1 0.0 5.2e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 EMC89710.1 - 7.5e-07 28.9 0.0 7.2e-05 22.5 0.0 1.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EMC89710.1 - 1.3e-06 27.5 0.0 0.0087 15.5 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_11 PF08976.11 EMC89710.1 - 0.00033 21.5 0.0 0.00056 20.7 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain DUF5580 PF17743.1 EMC89710.1 - 0.00044 18.9 0.0 0.00055 18.6 0.0 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5580) EF-hand_6 PF13405.6 EMC89710.1 - 0.00092 19.0 0.1 0.057 13.4 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain DUF3087 PF11286.8 EMC89710.1 - 0.069 12.6 0.0 0.2 11.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3087) DUF4203 PF13886.6 EMC89710.1 - 3.3 7.3 17.4 2.8 7.6 3.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4203) EF_assoc_2 PF08356.12 EMC89711.1 - 2e-36 123.8 0.0 5.8e-36 122.4 0.0 1.8 2 0 0 2 2 1 1 EF hand associated EF_assoc_1 PF08355.12 EMC89711.1 - 1.5e-29 101.4 0.9 9.7e-29 98.8 0.6 2.2 2 0 0 2 2 2 1 EF hand associated Ras PF00071.22 EMC89711.1 - 1.9e-23 82.8 0.3 3.3e-16 59.3 0.0 2.7 2 1 0 2 2 2 2 Ras family Roc PF08477.13 EMC89711.1 - 6.7e-08 32.8 0.0 8.1e-05 22.8 0.0 3.7 2 2 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase EF-hand_1 PF00036.32 EMC89711.1 - 1.4e-06 27.4 2.4 0.03 13.8 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EMC89711.1 - 5.8e-06 26.7 2.1 0.011 16.2 0.0 3.2 3 1 0 3 3 3 2 EF-hand domain pair RsgA_GTPase PF03193.16 EMC89711.1 - 1.7e-05 24.8 1.8 0.25 11.2 0.1 4.1 5 0 0 5 5 5 2 RsgA GTPase EF-hand_6 PF13405.6 EMC89711.1 - 3.3e-05 23.5 6.0 0.0038 17.0 0.1 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 EMC89711.1 - 0.0012 18.6 0.4 0.67 9.8 0.1 2.8 2 0 0 2 2 2 1 EF-hand domain pair Rad4 PF03835.15 EMC89711.1 - 0.0027 17.4 0.0 0.0057 16.4 0.0 1.5 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain MMR_HSR1 PF01926.23 EMC89711.1 - 0.022 14.8 0.2 4.6 7.4 0.0 3.0 2 2 0 2 2 2 0 50S ribosome-binding GTPase Dynamin_N PF00350.23 EMC89711.1 - 0.022 14.8 0.1 0.65 10.0 0.0 2.4 2 0 0 2 2 2 0 Dynamin family MMR_HSR1_Xtn PF16897.5 EMC89711.1 - 0.075 13.1 0.4 8.8 6.4 0.2 2.7 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain AAA_14 PF13173.6 EMC89711.1 - 0.09 12.8 0.0 6 6.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EMC89711.1 - 0.1 13.1 0.0 0.55 10.7 0.0 2.1 2 0 0 2 2 2 0 ABC transporter EF-hand_5 PF13202.6 EMC89711.1 - 0.28 10.8 2.4 18 5.0 0.1 2.5 2 0 0 2 2 2 0 EF hand SPRY PF00622.28 EMC89712.1 - 3.5e-13 49.7 0.0 4.3e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 SPRY domain DUF4299 PF14132.6 EMC89712.1 - 0.067 12.6 0.1 0.088 12.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4299) ArfGap PF01412.18 EMC89713.1 - 8.3e-27 93.6 0.1 1.5e-26 92.7 0.1 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 EMC89713.1 - 2e-21 76.4 0.0 3.1e-10 40.5 0.0 2.4 2 0 0 2 2 2 2 PH domain PH_8 PF15409.6 EMC89713.1 - 8.8e-09 35.5 1.4 0.0013 19.0 0.1 3.3 2 1 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.6 EMC89713.1 - 6.3e-07 29.8 5.3 0.0076 16.7 0.4 3.9 2 2 0 2 2 2 2 Pleckstrin homology domain Mcp5_PH PF12814.7 EMC89713.1 - 0.02 15.0 0.2 0.13 12.4 0.0 2.3 2 1 0 2 2 2 0 Meiotic cell cortex C-terminal pleckstrin homology DUF2804 PF10974.8 EMC89714.1 - 0.2 11.2 0.0 0.28 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2804) VEFS-Box PF09733.9 EMC89715.1 - 1.6e-54 183.4 2.9 3.2e-54 182.5 2.9 1.5 1 0 0 1 1 1 1 VEFS-Box of polycomb protein DUF2070 PF09843.9 EMC89715.1 - 0.004 15.5 0.0 0.0057 15.0 0.0 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2070) zf-C2H2 PF00096.26 EMC89715.1 - 7.4 7.2 6.5 28 5.4 6.5 2.1 1 0 0 1 1 1 0 Zinc finger, C2H2 type RBD-FIP PF09457.10 EMC89716.1 - 1.4e-17 63.3 3.3 1.4e-17 63.3 3.3 3.8 4 0 0 4 4 4 1 FIP domain bZIP_1 PF00170.21 EMC89716.1 - 0.00041 20.4 6.8 0.00041 20.4 6.8 6.1 3 1 3 6 6 5 2 bZIP transcription factor ZapB PF06005.12 EMC89716.1 - 0.0048 17.3 8.7 0.0048 17.3 8.7 5.3 3 3 1 4 4 4 2 Cell division protein ZapB bZIP_2 PF07716.15 EMC89716.1 - 0.0071 16.4 3.9 0.0071 16.4 3.9 6.7 6 1 0 6 6 5 1 Basic region leucine zipper Leu_zip PF15294.6 EMC89716.1 - 0.014 14.9 42.5 0.1 12.1 27.0 3.1 2 1 1 3 3 3 0 Leucine zipper DivIC PF04977.15 EMC89716.1 - 0.026 14.3 2.6 0.026 14.3 2.6 5.5 3 2 2 5 5 5 0 Septum formation initiator Shugoshin_N PF07558.11 EMC89716.1 - 0.077 12.9 18.4 0.28 11.1 1.3 4.7 4 0 0 4 4 4 0 Shugoshin N-terminal coiled-coil region Imm49 PF15575.6 EMC89716.1 - 0.16 11.7 3.0 0.12 12.1 0.9 1.9 2 0 0 2 2 2 0 Immunity protein 49 HAP1_N PF04849.13 EMC89716.1 - 0.66 9.1 52.4 0.038 13.2 36.1 2.4 1 1 1 2 2 2 0 HAP1 N-terminal conserved region Ax_dynein_light PF10211.9 EMC89716.1 - 0.85 9.5 46.2 0.83 9.6 10.5 4.1 1 1 3 4 4 4 0 Axonemal dynein light chain HALZ PF02183.18 EMC89716.1 - 1.2 9.4 27.7 0.18 12.1 2.4 4.5 4 0 0 4 4 4 0 Homeobox associated leucine zipper VGPC1_C PF16799.5 EMC89716.1 - 1.3 9.0 17.3 0.39 10.7 2.0 4.9 3 1 2 5 5 5 0 C-terminal membrane-localisation domain of ion-channel, VCN1 FlaC_arch PF05377.11 EMC89716.1 - 1.3 9.4 28.8 0.28 11.6 0.9 5.4 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) DUF2937 PF11157.8 EMC89716.1 - 3.7 7.2 6.0 0.66 9.7 0.8 2.5 3 2 0 3 3 3 0 Protein of unknown function (DUF2937) PikAIV_N PF18605.1 EMC89716.1 - 5 6.8 14.4 0.35 10.5 0.8 4.6 5 0 0 5 5 5 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain ATG16 PF08614.11 EMC89716.1 - 6.8 6.9 51.0 4.6 7.4 32.4 3.9 1 1 4 5 5 5 0 Autophagy protein 16 (ATG16) Jnk-SapK_ap_N PF09744.9 EMC89716.1 - 7.4 6.8 53.5 3.3 7.9 27.2 3.4 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 Fmp27_WPPW PF10359.9 EMC89716.1 - 8 5.2 39.8 0.85 8.4 15.7 3.2 1 1 2 3 3 3 0 RNA pol II promoter Fmp27 protein domain EF-hand_6 PF13405.6 EMC89717.1 - 0.007 16.2 0.1 0.012 15.5 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 EMC89717.1 - 0.01 16.3 0.0 0.012 16.0 0.0 1.2 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.32 EMC89717.1 - 0.016 14.7 0.2 0.024 14.1 0.2 1.3 1 0 0 1 1 1 0 EF hand EF-hand_9 PF14658.6 EMC89717.1 - 0.16 12.3 0.0 0.24 11.8 0.0 1.2 1 0 0 1 1 1 0 EF-hand domain Peptidase_S10 PF00450.22 EMC89718.1 - 1.7e-89 301.1 0.3 1.9e-89 301.0 0.3 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Hydrolase_4 PF12146.8 EMC89718.1 - 0.0077 15.5 0.2 0.26 10.5 0.0 2.4 3 0 0 3 3 3 1 Serine aminopeptidase, S33 UPF0114 PF03350.16 EMC89718.1 - 0.078 13.2 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein family, UPF0114 zf-RING_UBOX PF13445.6 EMC89720.1 - 3e-09 36.7 9.3 3.3e-09 36.6 9.3 1.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EMC89720.1 - 1.6e-08 34.5 9.2 1.8e-08 34.4 9.2 1.1 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 EMC89720.1 - 1.9e-07 30.8 7.0 2e-07 30.7 7.0 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC89720.1 - 1.9e-07 30.8 6.4 2.1e-07 30.7 6.4 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC89720.1 - 4.6e-06 26.9 6.9 4.9e-06 26.8 6.9 1.1 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EMC89720.1 - 6.7e-06 25.9 5.9 7.7e-06 25.7 5.9 1.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC89720.1 - 0.00011 22.1 7.6 0.00013 21.8 7.6 1.1 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_6 PF14835.6 EMC89720.1 - 0.005 16.7 3.8 0.0055 16.6 3.8 1.0 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 EMC89720.1 - 0.032 14.1 7.4 0.042 13.7 7.4 1.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 U-box PF04564.15 EMC89720.1 - 0.12 12.6 0.0 0.14 12.4 0.0 1.1 1 0 0 1 1 1 0 U-box domain zf-RING_11 PF17123.5 EMC89720.1 - 0.49 10.2 10.5 1.6 8.5 10.6 1.9 1 1 0 1 1 1 0 RING-like zinc finger Tfb4 PF03850.14 EMC89720.1 - 5.9 6.3 7.2 5.9 6.3 7.2 1.0 1 0 0 1 1 1 0 Transcription factor Tfb4 DUF4543 PF15076.6 EMC89721.1 - 1.6e-45 153.1 2.8 2e-45 152.8 2.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4543) Noggin PF05806.12 EMC89722.1 - 2.7e-105 351.0 0.9 3.1e-105 350.8 0.9 1.0 1 0 0 1 1 1 1 Noggin SulA PF03846.14 EMC89723.1 - 0.022 14.7 0.8 0.13 12.2 0.2 2.3 2 0 0 2 2 2 0 Cell division inhibitor SulA SPRY PF00622.28 EMC89724.1 - 4.8e-06 26.7 0.4 1.4e-05 25.1 0.4 1.8 1 0 0 1 1 1 1 SPRY domain PRY PF13765.6 EMC89724.1 - 0.0012 18.4 0.0 0.0044 16.6 0.0 2.0 1 0 0 1 1 1 1 SPRY-associated domain zf-B_box PF00643.24 EMC89724.1 - 0.0049 17.0 11.1 0.016 15.3 11.1 1.9 1 0 0 1 1 1 1 B-box zinc finger SKA1 PF07160.12 EMC89724.1 - 0.2 11.4 6.6 0.34 10.7 6.6 1.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF848 PF05852.11 EMC89724.1 - 0.91 9.6 6.9 1.4 9.1 6.5 1.5 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) LpqV PF17301.2 EMC89725.1 - 0.15 12.3 0.0 0.21 11.8 0.0 1.3 1 0 0 1 1 1 0 Putative lipoprotein LpqV GRAM PF02893.20 EMC89726.1 - 2.9e-16 59.4 0.0 3.8e-16 59.0 0.0 1.1 1 0 0 1 1 1 1 GRAM domain Vps36_ESCRT-II PF11605.8 EMC89726.1 - 0.027 14.6 0.0 0.042 14.0 0.0 1.3 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 bPH_3 PF14470.6 EMC89726.1 - 0.042 14.2 0.0 0.062 13.7 0.0 1.2 1 0 0 1 1 1 0 Bacterial PH domain C2 PF00168.30 EMC89727.1 - 8e-31 106.4 0.0 5.6e-15 55.5 0.0 4.2 2 1 0 2 2 2 2 C2 domain Membr_traf_MHD PF10540.9 EMC89727.1 - 1e-16 61.4 7.9 2.7e-09 37.4 0.1 3.2 2 1 1 3 3 3 2 Munc13 (mammalian uncoordinated) homology domain DUF4795 PF16043.5 EMC89727.1 - 0.84 9.2 5.7 0.25 10.9 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) zf_CCCH_5 PF18384.1 EMC89728.1 - 2.4e-20 72.4 14.1 2.4e-20 72.4 14.1 3.8 3 1 0 3 3 3 1 Unkempt Zinc finger domain 1 (Znf1) zf-CCCH PF00642.24 EMC89728.1 - 7.3e-06 25.8 6.1 4.2e-05 23.3 1.0 7.1 8 1 0 8 8 6 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 EMC89728.1 - 0.00011 22.0 10.6 0.00011 22.0 10.6 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DUF3450 PF11932.8 EMC89728.1 - 0.00022 20.6 6.2 0.00035 20.0 6.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) zf_CCCH_4 PF18345.1 EMC89728.1 - 0.00043 20.2 0.5 0.039 14.0 0.0 6.3 6 1 0 6 6 5 2 Zinc finger domain THOC7 PF05615.13 EMC89728.1 - 0.0015 18.8 0.6 0.0037 17.5 0.6 1.6 1 0 0 1 1 1 1 Tho complex subunit 7 Laminin_II PF06009.12 EMC89728.1 - 0.007 16.4 1.6 0.013 15.5 1.6 1.4 1 0 0 1 1 1 1 Laminin Domain II Fez1 PF06818.15 EMC89728.1 - 0.0086 16.5 9.4 0.019 15.4 9.4 1.5 1 0 0 1 1 1 1 Fez1 Sds3 PF08598.11 EMC89728.1 - 0.048 13.7 1.6 0.067 13.2 0.7 1.7 1 1 0 1 1 1 0 Sds3-like AalphaY_MDB PF04611.12 EMC89728.1 - 0.092 12.8 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Mating type protein A alpha Y mating type dependent binding region DUF2205 PF10224.9 EMC89728.1 - 0.34 10.9 4.8 0.16 12.0 1.4 2.2 2 0 0 2 2 2 0 Short coiled-coil protein Alanine_zipper PF11839.8 EMC89728.1 - 0.74 10.2 8.8 1.5 9.3 8.8 1.5 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein CENP-Q PF13094.6 EMC89728.1 - 0.91 9.7 8.4 1.9 8.6 8.4 1.5 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Exonuc_VII_L PF02601.15 EMC89728.1 - 0.95 9.0 2.9 1.5 8.3 2.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit RRP36 PF06102.12 EMC89728.1 - 1.3 9.0 8.9 1.2 9.0 5.5 2.4 2 1 0 2 2 2 0 rRNA biogenesis protein RRP36 Ribosomal_S27e PF01667.17 EMC89728.1 - 1.6 8.5 7.3 4.2 7.2 7.3 1.6 1 0 0 1 1 1 0 Ribosomal protein S27 DUF3584 PF12128.8 EMC89728.1 - 3.7 4.9 13.6 5.1 4.5 13.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ERM PF00769.19 EMC89728.1 - 5.2 6.8 14.1 9.4 6.0 14.1 1.4 1 0 0 1 1 1 0 Ezrin/radixin/moesin family GAS PF13851.6 EMC89728.1 - 7 5.9 13.1 17 4.7 13.1 1.6 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding PID PF00640.23 EMC89729.1 - 0.00071 19.6 0.1 0.00088 19.3 0.1 1.1 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) HCNGP PF07818.13 EMC89731.1 - 1.7e-34 118.3 0.2 3.1e-34 117.5 0.2 1.4 1 0 0 1 1 1 1 HCNGP-like protein Na_trans_assoc PF06512.13 EMC89731.1 - 1.2 9.4 10.0 0.32 11.2 5.7 2.0 2 0 0 2 2 2 0 Sodium ion transport-associated RecQ5 PF06959.11 EMC89732.1 - 3.2e-26 92.6 14.0 9.2e-26 91.1 14.0 1.8 1 0 0 1 1 1 1 RecQ helicase protein-like 5 (RecQ5) DEAD PF00270.29 EMC89732.1 - 3.7e-20 72.4 0.1 7.5e-20 71.4 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC89732.1 - 6.1e-16 58.8 0.0 5.7e-12 46.0 0.0 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 EMC89732.1 - 8.1e-10 39.3 2.1 2.6e-09 37.7 2.1 2.0 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 EMC89732.1 - 0.00016 21.7 0.0 0.00036 20.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit TFIIS_M PF07500.14 EMC89732.1 - 0.01 16.3 0.0 0.038 14.5 0.0 2.0 1 0 0 1 1 1 0 Transcription factor S-II (TFIIS), central domain KIX_2 PF16987.5 EMC89732.1 - 0.065 13.2 0.1 0.2 11.7 0.1 1.8 1 0 0 1 1 1 0 KIX domain SRI PF08236.11 EMC89732.1 - 0.078 13.2 0.1 0.078 13.2 0.1 2.4 3 0 0 3 3 3 0 SRI (Set2 Rpb1 interacting) domain FKBP26_C PF18046.1 EMC89732.1 - 0.14 12.3 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 FKBP26_C-terminal DUF4713 PF15831.5 EMC89733.1 - 2.9e-23 82.1 11.4 3.4e-23 81.8 11.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4713) DUF3593 PF12159.8 EMC89733.1 - 0.00047 20.1 0.0 0.00056 19.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3593) Shisa PF13908.6 EMC89733.1 - 0.0009 19.5 1.9 0.0009 19.5 1.9 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Corona_S2 PF01601.16 EMC89733.1 - 0.014 13.9 3.6 0.014 13.9 3.6 1.0 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Prominin PF05478.11 EMC89733.1 - 1.8 6.4 10.2 1.9 6.3 10.2 1.0 1 0 0 1 1 1 0 Prominin Comm PF15957.5 EMC89733.1 - 2.7 8.3 5.4 3.3 8.1 5.4 1.2 1 0 0 1 1 1 0 Commissureless MyTH4 PF00784.17 EMC89734.1 - 5e-31 107.4 0.8 3.1e-30 104.8 0.1 2.4 3 0 0 3 3 3 1 MyTH4 domain FERM_M PF00373.18 EMC89734.1 - 1.2e-11 45.0 0.5 3.9e-11 43.4 0.5 1.8 1 0 0 1 1 1 1 FERM central domain SH3_2 PF07653.17 EMC89735.1 - 2.4e-11 43.1 0.0 4.3e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EMC89735.1 - 4.5e-07 29.6 0.0 8.1e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC89735.1 - 0.0037 16.8 0.0 0.006 16.2 0.0 1.3 1 0 0 1 1 1 1 SH3 domain Myosin_head PF00063.21 EMC89736.1 - 5.2e-196 652.9 0.0 6.3e-196 652.6 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) MyTH4 PF00784.17 EMC89736.1 - 1.9e-21 76.6 0.0 7.5e-21 74.7 0.0 2.2 1 0 0 1 1 1 1 MyTH4 domain IQ PF00612.27 EMC89736.1 - 2.2e-07 30.1 12.4 8.5e-06 25.1 2.0 3.2 2 0 0 2 2 2 2 IQ calmodulin-binding motif AAA_16 PF13191.6 EMC89736.1 - 0.00062 20.2 0.1 0.0057 17.1 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EMC89736.1 - 0.0031 17.8 0.2 0.013 15.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EMC89736.1 - 0.044 12.8 0.0 0.083 11.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Zeta_toxin PF06414.12 EMC89736.1 - 0.049 12.9 0.0 0.12 11.6 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.6 EMC89736.1 - 0.079 13.1 0.8 0.37 10.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain RTC4 PF14474.6 EMC89736.1 - 0.081 13.1 0.0 0.31 11.2 0.0 2.0 1 0 0 1 1 1 0 RTC4-like domain Sigma54_activat PF00158.26 EMC89736.1 - 0.099 12.3 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain TsaE PF02367.17 EMC89736.1 - 0.099 12.6 0.0 0.31 11.0 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EMC89736.1 - 0.12 12.9 0.0 0.35 11.4 0.0 1.8 1 0 0 1 1 1 0 ABC transporter tRNA_int_end_N2 PF12928.7 EMC89737.1 - 7.3e-15 54.9 0.1 1.6e-14 53.8 0.1 1.6 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term 7tm_1 PF00001.21 EMC89738.1 - 4.1e-50 170.6 22.1 4.8e-50 170.3 22.1 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC89738.1 - 2.4e-10 40.2 21.1 2.8e-10 40.0 21.1 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC89738.1 - 0.00044 20.0 15.3 0.00044 20.0 15.3 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF2157 PF09925.9 EMC89738.1 - 7.3 6.4 11.9 0.077 12.8 3.3 2.0 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) SH3_1 PF00018.28 EMC89740.1 - 2.8e-34 116.5 0.8 8.4e-17 60.5 0.1 2.6 3 0 0 3 3 3 2 SH3 domain SH3_9 PF14604.6 EMC89740.1 - 1.3e-28 98.6 0.2 1.8e-15 56.5 0.1 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 EMC89740.1 - 3.9e-26 90.5 0.0 1.1e-15 57.0 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH2 PF00017.24 EMC89740.1 - 1.3e-24 86.1 0.0 2.1e-24 85.4 0.0 1.4 1 0 0 1 1 1 1 SH2 domain SH3_10 PF17902.1 EMC89740.1 - 1.2e-05 25.2 0.0 0.00048 20.2 0.0 2.5 2 1 0 2 2 2 1 SH3 domain SH2_2 PF14633.6 EMC89740.1 - 0.0045 16.4 0.0 0.007 15.8 0.0 1.3 1 0 0 1 1 1 1 SH2 domain SH3_3 PF08239.11 EMC89740.1 - 0.0059 16.9 0.1 0.04 14.2 0.0 2.1 2 0 0 2 2 2 1 Bacterial SH3 domain hSH3 PF14603.6 EMC89740.1 - 0.0066 16.9 0.0 0.069 13.6 0.0 2.3 2 0 0 2 2 2 1 Helically-extended SH3 domain DUF5093 PF17011.5 EMC89740.1 - 0.021 15.1 0.2 0.04 14.2 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5093) SH3_4 PF06347.13 EMC89740.1 - 0.077 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial SH3 domain MIF4G PF02854.19 EMC89741.1 - 1.2e-08 34.8 2.0 1.8e-08 34.3 2.0 1.2 1 0 0 1 1 1 1 MIF4G domain KRAB PF01352.27 EMC89741.1 - 0.064 12.9 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 KRAB box Ribosomal_S7 PF00177.21 EMC89742.1 - 2.5e-39 134.3 0.2 3.2e-39 134.0 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e DUF719 PF05334.13 EMC89742.1 - 0.061 13.5 0.2 0.18 12.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF719) VHS PF00790.19 EMC89743.1 - 1.1e-45 154.9 1.6 4.4e-45 153.0 0.0 2.3 2 1 0 2 2 2 1 VHS domain Alpha_adaptinC2 PF02883.20 EMC89743.1 - 3.1e-31 108.0 0.0 5.9e-31 107.1 0.0 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain GGA_N-GAT PF18308.1 EMC89743.1 - 4.8e-21 74.1 6.7 4.8e-21 74.1 6.7 2.0 2 0 0 2 2 2 1 GGA N-GAT domain GAT PF03127.14 EMC89743.1 - 2.1e-19 69.6 2.6 2.1e-19 69.6 2.6 2.5 2 0 0 2 2 2 1 GAT domain HD_2 PF12917.7 EMC89743.1 - 0.02 14.6 0.4 0.042 13.6 0.4 1.5 1 0 0 1 1 1 0 HD containing hydrolase-like enzyme SesA PF17107.5 EMC89743.1 - 0.029 14.6 1.0 0.07 13.3 1.0 1.7 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases AP3B1_C PF14796.6 EMC89743.1 - 0.07 13.4 0.1 3.3 8.0 0.0 2.5 2 0 0 2 2 2 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal HBM PF16591.5 EMC89743.1 - 0.12 11.8 2.3 0.2 11.1 2.3 1.2 1 0 0 1 1 1 0 Helical bimodular sensor domain zf-C4H2 PF10146.9 EMC89743.1 - 0.39 11.0 6.2 4.2 7.6 1.3 2.5 2 1 0 2 2 2 0 Zinc finger-containing protein PCRF PF03462.18 EMC89743.1 - 2.4 8.0 5.3 4 7.3 5.3 1.3 1 0 0 1 1 1 0 PCRF domain Rad60-SLD PF11976.8 EMC89744.1 - 4.2e-26 90.6 0.1 5e-26 90.3 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EMC89744.1 - 2.2e-12 46.5 0.1 2.6e-12 46.3 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin family JUPITER PF17054.5 EMC89745.1 - 0.00088 18.9 0.1 0.00088 18.9 0.1 1.8 2 1 0 2 2 2 1 Microtubule-Associated protein Jupiter NT5C PF06941.12 EMC89746.1 - 7.7e-18 65.0 0.0 8.4e-18 64.9 0.0 1.0 1 0 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Arm PF00514.23 EMC89747.1 - 6.8e-12 45.0 0.0 2.3e-06 27.4 0.0 2.9 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat RICTOR_N PF14664.6 EMC89747.1 - 0.0012 17.9 0.4 0.0032 16.5 0.3 1.5 1 1 1 2 2 2 1 Rapamycin-insensitive companion of mTOR, N-term Arm_2 PF04826.13 EMC89747.1 - 0.012 15.0 0.1 2.7 7.4 0.0 2.0 1 1 1 2 2 2 0 Armadillo-like MFS_1 PF07690.16 EMC89748.1 - 1.1e-38 133.1 47.5 1.8e-32 112.6 30.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily BTB_2 PF02214.22 EMC89749.1 - 2e-11 44.1 0.0 3.5e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 EMC89749.1 - 0.015 15.6 0.0 0.022 15.0 0.0 1.3 1 0 0 1 1 1 0 BTB/POZ domain SAM_LFY PF01698.16 EMC89749.1 - 0.056 13.4 0.2 0.36 10.8 0.0 2.0 2 0 0 2 2 2 0 Floricaula / Leafy protein SAM domain Neur_chan_LBD PF02931.23 EMC89751.1 - 4.9e-22 78.4 2.2 5.9e-22 78.2 2.2 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 EMC89751.1 - 0.0023 18.0 4.2 0.0023 18.0 3.3 1.4 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region RF-1 PF00472.20 EMC89752.1 - 1.1e-19 70.5 3.3 1.4e-19 70.1 3.3 1.0 1 0 0 1 1 1 1 RF-1 domain Collectrin PF16959.5 EMC89752.1 - 0.69 9.7 4.1 9.6 6.0 1.3 2.1 1 1 1 2 2 2 0 Renal amino acid transporter zf-ZPR1 PF03367.13 EMC89753.1 - 0.032 14.1 0.4 0.032 14.1 0.4 3.8 3 1 1 4 4 4 0 ZPR1 zinc-finger domain Lectin_N PF03954.14 EMC89753.1 - 0.044 13.5 0.8 0.044 13.5 0.8 5.1 4 1 1 5 5 5 0 Hepatic lectin, N-terminal domain DUF3540 PF12059.8 EMC89753.1 - 0.053 13.3 10.1 0.15 11.9 0.4 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3540) PMC2NT PF08066.12 EMC89753.1 - 0.34 11.6 9.2 0.36 11.5 0.4 3.6 3 1 0 3 3 3 0 PMC2NT (NUC016) domain DUF1664 PF07889.12 EMC89753.1 - 1.3 9.1 30.0 8.5 6.4 9.2 4.5 3 2 1 4 4 4 0 Protein of unknown function (DUF1664) FliD_C PF07195.12 EMC89753.1 - 1.7 8.0 18.0 0.25 10.8 3.9 3.7 3 1 0 4 4 4 0 Flagellar hook-associated protein 2 C-terminus BLOC1_2 PF10046.9 EMC89753.1 - 7.5 6.9 37.8 0.079 13.3 14.0 4.9 4 2 1 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Hid1 PF12722.7 EMC89754.1 - 3.1e-275 915.4 0.0 3.8e-275 915.1 0.0 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 EMC89754.1 - 2.3e-257 855.5 0.0 2.6e-257 855.3 0.0 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Otopetrin PF03189.13 EMC89755.1 - 1.1e-27 97.0 28.7 5.7e-13 48.5 3.2 3.0 1 1 1 2 2 2 2 Otopetrin DUF1772 PF08592.11 EMC89755.1 - 0.0074 16.6 0.8 0.15 12.4 1.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF1772) Ank_2 PF12796.7 EMC89756.1 - 9.2e-29 99.9 0.5 1.9e-15 57.2 0.2 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC89756.1 - 2.3e-22 79.0 4.5 2.8e-12 46.9 0.2 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EMC89756.1 - 3.1e-13 49.5 2.5 3.2e-07 30.5 0.2 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EMC89756.1 - 1.3e-12 47.7 1.1 4.7e-07 30.0 0.3 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC89756.1 - 1.7e-12 46.4 0.8 4.5e-05 23.5 0.2 4.0 4 0 0 4 4 4 3 Ankyrin repeat SAM_1 PF00536.30 EMC89756.1 - 1.3e-10 41.5 0.1 7.7e-10 39.1 0.0 2.3 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SR-25 PF10500.9 EMC89756.1 - 2.8 7.5 12.9 4.7 6.8 12.9 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Aa_trans PF01490.18 EMC89757.1 - 4e-16 58.7 30.5 2.1e-08 33.3 3.4 2.2 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EMC89757.1 - 2.7e-05 23.4 19.1 0.00066 18.8 1.4 2.6 2 1 0 2 2 2 2 Tryptophan/tyrosine permease family Cytomega_UL84 PF06284.11 EMC89757.1 - 0.065 11.7 0.0 0.093 11.2 0.0 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein EBP50_C PF09007.11 EMC89758.1 - 4.1e-29 102.2 0.1 6.4e-29 101.6 0.1 1.3 1 0 0 1 1 1 1 EBP50, C-terminal PDZ_6 PF17820.1 EMC89758.1 - 1.5e-16 59.9 0.5 2.5e-16 59.3 0.5 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 EMC89758.1 - 1.5e-14 54.1 0.0 2.5e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMC89758.1 - 5.3e-07 29.9 0.2 1.1e-06 28.8 0.1 1.7 2 0 0 2 2 2 1 PDZ domain Ras PF00071.22 EMC89759.1 - 6.5e-59 198.1 0.2 7.7e-59 197.9 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC89759.1 - 2.3e-32 111.7 0.1 3.4e-32 111.2 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC89759.1 - 4.4e-14 52.3 0.0 5.6e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EMC89759.1 - 5.8e-06 25.8 0.0 7.6e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EMC89759.1 - 0.00036 20.5 0.3 0.21 11.5 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EMC89759.1 - 0.0024 17.9 0.0 0.0045 17.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.6 EMC89759.1 - 0.028 14.1 0.1 0.055 13.2 0.1 1.4 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 EMC89759.1 - 0.031 13.6 0.1 0.091 12.0 0.1 1.8 1 1 0 1 1 1 0 Septin DAP3 PF10236.9 EMC89759.1 - 0.053 12.7 0.2 0.12 11.6 0.1 1.6 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 EMC89759.1 - 0.056 13.8 0.1 0.14 12.6 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain V-set PF07686.17 EMC89760.1 - 5.7e-12 45.8 0.5 7.3e-12 45.4 0.5 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 EMC89760.1 - 8.9e-05 22.6 0.1 0.023 14.9 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 EMC89760.1 - 0.00041 20.6 0.6 0.003 17.9 0.6 2.0 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC89760.1 - 0.0027 18.3 0.4 0.0077 16.8 0.4 1.8 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC89760.1 - 0.048 13.7 0.0 0.21 11.7 0.0 2.0 2 1 0 2 2 2 0 Immunoglobulin I-set domain V-set PF07686.17 EMC89761.1 - 0.0037 17.4 0.0 0.0037 17.4 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain V-set PF07686.17 EMC89762.1 - 2.1e-06 27.9 0.0 2.1e-06 27.8 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 EMC89762.1 - 0.00014 22.0 0.0 0.00014 22.0 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin domain Izumo-Ig PF16706.5 EMC89762.1 - 0.045 13.8 0.0 0.045 13.8 0.0 1.1 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain DUF4519 PF15012.6 EMC89763.1 - 5.2 7.3 6.3 2.4 8.4 2.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4519) Xylo_C PF12529.8 EMC89764.1 - 1.7e-69 233.1 0.0 2.7e-69 232.4 0.0 1.3 1 0 0 1 1 1 1 Xylosyltransferase C terminal Branch PF02485.21 EMC89764.1 - 2.8e-55 187.5 1.5 3.9e-55 187.1 1.5 1.2 1 0 0 1 1 1 1 Core-2/I-Branching enzyme Ribosomal_L27 PF01016.19 EMC89765.1 - 1.2e-25 89.3 0.1 1.5e-25 89.0 0.1 1.2 1 0 0 1 1 1 1 Ribosomal L27 protein Catalase-rel PF06628.12 EMC89766.1 - 0.051 13.8 0.0 1.1 9.5 0.0 2.4 2 0 0 2 2 2 0 Catalase-related immune-responsive LRR_8 PF13855.6 EMC89767.1 - 1.3e-13 50.5 17.9 1.1e-10 41.1 7.8 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EMC89767.1 - 1.6e-09 37.8 17.0 2.3e-06 27.8 3.0 2.9 3 0 0 3 3 2 2 Leucine Rich repeats (2 copies) Hid1 PF12722.7 EMC89767.1 - 0.0018 16.5 2.5 0.0019 16.4 2.5 1.2 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein AAA_11 PF13086.6 EMC89767.1 - 0.0037 17.1 6.6 0.0054 16.6 6.6 1.2 1 0 0 1 1 1 1 AAA domain LRR_1 PF00560.33 EMC89767.1 - 0.0094 16.4 20.0 7.1 7.6 0.4 5.7 6 0 0 6 6 5 1 Leucine Rich Repeat NPR3 PF03666.13 EMC89767.1 - 0.031 13.1 7.3 0.04 12.7 7.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DDHD PF02862.17 EMC89767.1 - 0.071 13.3 2.1 0.087 13.0 2.1 1.2 1 0 0 1 1 1 0 DDHD domain GAGA_bind PF06217.12 EMC89767.1 - 0.095 13.0 10.2 0.13 12.5 10.2 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family MAJIN PF15077.6 EMC89767.1 - 0.11 12.3 9.8 0.15 11.8 9.8 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein CobT PF06213.12 EMC89767.1 - 0.13 11.6 17.2 0.19 11.1 17.2 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Presenilin PF01080.17 EMC89767.1 - 0.18 10.5 10.0 0.25 10.1 10.0 1.2 1 0 0 1 1 1 0 Presenilin DUF5427 PF10310.9 EMC89767.1 - 0.24 10.3 12.8 0.32 9.9 12.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Hydin_ADK PF17213.3 EMC89767.1 - 0.3 11.4 9.2 0.45 10.8 9.2 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain ALMT PF11744.8 EMC89767.1 - 0.7 8.7 6.2 0.89 8.3 6.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Neur_chan_memb PF02932.16 EMC89767.1 - 1.8 8.6 5.9 2.5 8.1 5.9 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Atrophin-1 PF03154.15 EMC89767.1 - 2.7 6.2 21.5 3.7 5.7 21.5 1.3 1 0 0 1 1 1 0 Atrophin-1 family Red1 PF07964.11 EMC89767.1 - 2.8 6.1 18.5 3.7 5.7 18.5 1.1 1 0 0 1 1 1 0 Rec10 / Red1 V_ATPase_I PF01496.19 EMC89767.1 - 2.9 5.7 6.1 3.6 5.4 6.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Borrelia_P83 PF05262.11 EMC89767.1 - 6.4 5.1 21.7 8.2 4.8 21.7 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein AMP-binding PF00501.28 EMC89768.1 - 3e-105 352.3 0.0 3.5e-105 352.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMC89768.1 - 4.2e-17 62.9 0.2 8.5e-17 61.9 0.2 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain LRR_8 PF13855.6 EMC89769.1 - 3.9e-52 173.9 37.4 6.5e-13 48.2 0.6 5.4 1 1 5 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 EMC89769.1 - 1.7e-19 69.5 22.8 0.00011 22.5 0.1 6.9 2 1 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC89769.1 - 5.9e-15 55.4 0.0 1.5e-06 28.2 0.0 2.7 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EMC89769.1 - 1.8e-08 33.8 16.6 0.29 11.8 0.0 9.6 10 1 1 11 11 11 1 Leucine Rich Repeat LRRNT PF01462.18 EMC89769.1 - 4.7e-08 32.5 4.3 4.7e-08 32.5 4.3 2.5 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.6 EMC89769.1 - 5.2e-08 32.6 5.9 0.017 14.6 0.0 3.5 1 1 1 3 3 3 3 Leucine-rich repeat Rv2175c_C PF18367.1 EMC89769.1 - 0.0069 16.4 0.1 0.23 11.6 0.0 3.1 2 1 0 2 2 2 1 Rv2175c C-terminal domain of unknown function LRR_2 PF07723.13 EMC89769.1 - 0.022 15.4 5.6 12 6.8 0.0 6.4 8 0 0 8 8 8 0 Leucine Rich Repeat LRRCT PF01463.24 EMC89769.1 - 0.034 14.7 0.0 0.15 12.7 0.0 2.2 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain Radical_SAM PF04055.21 EMC89770.1 - 4.5e-15 56.4 0.0 1.2e-14 55.0 0.0 1.6 2 0 0 2 2 2 1 Radical SAM superfamily HemN_C PF06969.16 EMC89770.1 - 9.3e-07 28.8 0.2 2.1e-06 27.7 0.2 1.7 1 0 0 1 1 1 1 HemN C-terminal domain Thioredox_DsbH PF03190.15 EMC89771.1 - 1.6e-72 242.8 0.0 2.7e-72 242.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 EMC89771.1 - 1.6e-10 41.0 0.0 3.4e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like C5-epim_C PF06662.13 EMC89771.1 - 0.0051 16.3 0.5 0.22 11.0 0.1 2.4 2 0 0 2 2 2 1 D-glucuronyl C5-epimerase C-terminus Plant_NMP1 PF06694.11 EMC89771.1 - 0.018 14.2 0.0 0.061 12.4 0.0 1.8 2 0 0 2 2 2 0 Plant nuclear matrix protein 1 (NMP1) ABC_membrane PF00664.23 EMC89772.1 - 6.4e-88 295.0 31.4 8.2e-49 166.7 7.7 2.5 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EMC89772.1 - 8.6e-55 185.0 0.2 3e-29 102.3 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EMC89772.1 - 1.2e-09 37.9 0.1 0.0018 17.7 0.0 4.0 2 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EMC89772.1 - 4.2e-06 26.8 0.4 0.03 14.4 0.0 3.1 3 0 0 3 3 3 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC89772.1 - 7.6e-05 22.7 1.0 0.018 15.0 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EMC89772.1 - 9.9e-05 22.8 0.3 0.072 13.5 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EMC89772.1 - 0.0046 17.2 0.1 6.5 7.0 0.0 3.2 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EMC89772.1 - 0.014 15.1 1.6 2.6 7.9 0.1 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_7 PF12775.7 EMC89772.1 - 0.02 14.4 0.4 0.92 9.0 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_25 PF13481.6 EMC89772.1 - 0.03 13.9 0.6 0.78 9.3 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EMC89772.1 - 0.073 13.6 5.9 2.6 8.5 0.0 3.6 4 0 0 4 4 4 0 AAA domain Dynamin_N PF00350.23 EMC89772.1 - 0.075 13.1 3.7 0.31 11.1 0.6 2.8 2 0 0 2 2 2 0 Dynamin family GTP_EFTU PF00009.27 EMC89772.1 - 0.092 12.3 0.1 0.91 9.0 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain DUF815 PF05673.13 EMC89772.1 - 0.1 11.7 1.1 1.3 8.1 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) RNA_helicase PF00910.22 EMC89772.1 - 0.15 12.5 0.1 11 6.5 0.0 2.9 2 0 0 2 2 2 0 RNA helicase DUF87 PF01935.17 EMC89772.1 - 0.69 10.0 6.4 3.6 7.6 0.2 2.8 3 0 0 3 3 3 0 Helicase HerA, central domain Ank_5 PF13857.6 EMC89773.1 - 3.8e-05 23.9 0.1 0.00011 22.5 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EMC89773.1 - 0.00016 22.0 0.1 0.00036 20.8 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.6 EMC89773.1 - 0.00027 21.1 0.1 0.00059 20.1 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.7 EMC89773.1 - 0.0045 17.5 0.0 0.0076 16.8 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC89773.1 - 0.032 14.8 0.1 0.061 13.9 0.1 1.4 1 0 0 1 1 1 0 Ankyrin repeats (many copies) NOP5NT PF08156.13 EMC89774.1 - 0.058 13.8 0.1 0.089 13.2 0.1 1.3 1 0 0 1 1 1 0 NOP5NT (NUC127) domain Kunitz_BPTI PF00014.23 EMC89775.1 - 1.7e-31 108.2 34.0 1.6e-20 73.1 6.7 3.4 3 0 0 3 3 3 2 Kunitz/Bovine pancreatic trypsin inhibitor domain I-set PF07679.16 EMC89775.1 - 8.9e-17 60.9 0.0 1.7e-16 60.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC89775.1 - 1.3e-14 54.6 0.2 3.7e-14 53.1 0.2 1.9 1 0 0 1 1 1 1 Immunoglobulin domain NTR PF01759.21 EMC89775.1 - 6.9e-11 41.9 0.0 1.5e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 UNC-6/NTR/C345C module Ig_2 PF13895.6 EMC89775.1 - 3.4e-10 40.1 0.0 1.1e-09 38.5 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC89775.1 - 7.5e-10 38.8 0.0 1.6e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain WAP PF00095.21 EMC89775.1 - 6e-08 33.0 11.0 6e-08 33.0 11.0 4.5 5 1 0 5 5 5 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' V-set PF07686.17 EMC89775.1 - 6.6e-06 26.3 2.3 4.5e-05 23.6 0.1 2.9 2 1 0 2 2 2 1 Immunoglobulin V-set domain BTG PF07742.12 EMC89776.1 - 1.4e-38 131.3 0.0 2.5e-38 130.5 0.0 1.4 1 0 0 1 1 1 1 BTG family PAM2 PF07145.15 EMC89776.1 - 4.3e-06 26.0 3.2 0.0083 15.8 0.3 2.9 2 0 0 2 2 2 2 Ataxin-2 C-terminal region JIP_LZII PF16471.5 EMC89777.1 - 5.7e-30 103.3 13.1 5.7e-30 103.3 13.1 5.0 6 0 0 6 6 6 1 JNK-interacting protein leucine zipper II Jnk-SapK_ap_N PF09744.9 EMC89777.1 - 4.7e-20 72.4 12.3 4.7e-20 72.4 12.3 4.6 5 1 1 6 6 6 1 JNK_SAPK-associated protein-1 YabA PF06156.13 EMC89777.1 - 0.0062 17.2 21.8 0.032 14.9 4.1 3.6 3 0 0 3 3 3 2 Initiation control protein YabA Sipho_Gp157 PF05565.11 EMC89777.1 - 0.39 10.7 23.8 0.032 14.2 5.4 2.7 2 0 0 2 2 2 0 Siphovirus Gp157 NDK PF00334.19 EMC89778.1 - 2.8e-98 325.2 0.0 2.3e-55 186.3 0.0 2.0 2 0 0 2 2 2 2 Nucleoside diphosphate kinase PSI_PsaJ PF01701.18 EMC89778.1 - 0.0093 16.5 0.0 5.6 7.6 0.0 2.3 2 0 0 2 2 2 2 Photosystem I reaction centre subunit IX / PsaJ MarR PF01047.22 EMC89778.1 - 0.012 15.5 0.0 7.5 6.6 0.0 2.3 2 0 0 2 2 2 0 MarR family Peptidase_S77 PF03420.13 EMC89778.1 - 0.027 14.1 0.2 2 8.0 0.0 2.2 2 0 0 2 2 2 0 Prohead core protein serine protease GFRP PF06399.13 EMC89778.1 - 0.072 13.0 0.0 11 6.0 0.0 2.4 2 0 0 2 2 2 0 GTP cyclohydrolase I feedback regulatory protein (GFRP) MBT PF02820.18 EMC89779.1 - 9.6e-92 301.4 2.3 7.3e-28 96.7 0.1 4.3 4 0 0 4 4 4 4 mbt repeat C1_2 PF03107.16 EMC89779.1 - 0.028 14.7 3.0 1.7 9.0 0.0 3.4 3 0 0 3 3 3 0 C1 domain WD40 PF00400.32 EMC89780.1 - 2.8e-08 34.3 0.0 1 10.4 0.0 6.0 5 1 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC89780.1 - 1.1e-05 25.6 0.0 7.9 6.9 0.0 4.7 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Formyl_trans_C PF02911.18 EMC89780.1 - 0.089 13.0 0.0 0.26 11.6 0.0 1.8 1 0 0 1 1 1 0 Formyl transferase, C-terminal domain Carb_anhydrase PF00194.21 EMC89781.1 - 1e-56 192.3 0.1 1.2e-56 192.1 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase VHS PF00790.19 EMC89782.1 - 1.7e-18 66.8 0.2 3.2e-18 65.9 0.2 1.4 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 EMC89782.1 - 5e-18 65.2 2.9 5e-18 65.2 2.9 1.7 2 0 0 2 2 2 1 GAT domain CtaG_Cox11 PF04442.14 EMC89783.1 - 8.8e-44 149.2 2.4 1.1e-43 148.9 2.4 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 WW PF00397.26 EMC89784.1 - 2e-11 43.8 0.6 3.2e-11 43.1 0.6 1.3 1 0 0 1 1 1 1 WW domain PDZ PF00595.24 EMC89784.1 - 1.5e-10 41.3 0.1 4e-10 39.9 0.1 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC89784.1 - 8.6e-05 22.3 0.1 0.0004 20.2 0.0 2.2 2 0 0 2 2 2 1 PDZ domain Pox_A11 PF05061.13 EMC89784.1 - 0.0092 15.3 2.5 0.016 14.5 2.5 1.3 1 0 0 1 1 1 1 Poxvirus A11 Protein DivIVA PF05103.13 EMC89784.1 - 0.096 12.8 15.3 0.51 10.4 15.2 2.3 2 1 0 2 2 2 0 DivIVA protein DUF1664 PF07889.12 EMC89784.1 - 0.1 12.7 11.4 0.053 13.6 4.9 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Seryl_tRNA_N PF02403.22 EMC89784.1 - 0.16 12.2 16.8 0.1 12.8 9.9 2.8 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Golgin_A5 PF09787.9 EMC89784.1 - 0.47 9.9 20.2 0.11 12.0 16.8 1.5 2 0 0 2 2 2 0 Golgin subfamily A member 5 TPR_MLP1_2 PF07926.12 EMC89784.1 - 1.3 9.1 25.7 0.08 13.0 18.8 2.4 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein LMBR1 PF04791.16 EMC89784.1 - 2.5 6.9 3.5 3.7 6.3 3.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4407 PF14362.6 EMC89784.1 - 4.8 6.4 14.2 10 5.4 14.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF5082 PF16888.5 EMC89784.1 - 5.4 7.3 12.5 12 6.2 11.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) zf-C4H2 PF10146.9 EMC89784.1 - 5.7 7.2 11.1 13 6.1 11.1 1.5 1 0 0 1 1 1 0 Zinc finger-containing protein Phage_GP20 PF06810.11 EMC89784.1 - 6.5 6.5 15.1 5.3 6.8 9.4 2.3 1 1 1 2 2 2 0 Phage minor structural protein GP20 bZIP_2 PF07716.15 EMC89785.1 - 1.1e-17 63.8 12.7 2.3e-17 62.8 12.7 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EMC89785.1 - 7.9e-05 22.7 9.1 0.00016 21.7 9.1 1.4 1 0 0 1 1 1 1 bZIP transcription factor Cnn_1N PF07989.11 EMC89785.1 - 0.013 15.6 0.6 0.029 14.5 0.6 1.6 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 bZIP_Maf PF03131.17 EMC89785.1 - 0.028 14.9 7.9 0.033 14.7 7.1 1.6 1 1 0 1 1 1 0 bZIP Maf transcription factor IER PF05760.12 EMC89785.1 - 0.086 13.1 0.6 0.15 12.3 0.2 1.6 1 1 1 2 2 2 0 Immediate early response protein (IER) HMMR_C PF15908.5 EMC89785.1 - 0.088 13.1 0.8 0.088 13.1 0.8 1.9 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor C-terminal HlyIII PF03006.20 EMC89786.1 - 7.1e-20 71.7 22.1 8.7e-20 71.4 22.1 1.1 1 0 0 1 1 1 1 Haemolysin-III related TMEM100 PF16311.5 EMC89787.1 - 3.3e-66 220.9 0.4 3.6e-66 220.8 0.4 1.0 1 0 0 1 1 1 1 Transmembrane protein 100 Neurensin PF14927.6 EMC89787.1 - 2e-05 24.3 1.3 0.02 14.6 0.3 2.1 1 1 1 2 2 2 2 Neurensin PIRT PF15099.6 EMC89787.1 - 4.1e-05 23.2 0.3 6.2e-05 22.6 0.3 1.2 1 0 0 1 1 1 1 Phosphoinositide-interacting protein family Claudin_2 PF13903.6 EMC89787.1 - 0.0015 18.4 1.0 0.0017 18.1 1.0 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Saf_2TM PF18303.1 EMC89787.1 - 0.061 12.9 0.3 0.099 12.2 0.3 1.4 1 1 0 1 1 1 0 SAVED-fused 2TM effector domain DUF2371 PF10177.9 EMC89787.1 - 0.062 13.5 0.9 0.17 12.1 0.9 1.7 1 1 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) TMEM51 PF15345.6 EMC89787.1 - 0.071 13.0 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 UPF0542 PF15086.6 EMC89787.1 - 0.11 12.4 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 TMEM252 PF15664.5 EMC89787.1 - 0.5 10.1 1.5 15 5.3 0.3 2.2 1 1 1 2 2 2 0 Transmembrane protein 252 family START PF01852.19 EMC89788.1 - 5.7e-33 114.1 0.0 6.8e-33 113.8 0.0 1.0 1 0 0 1 1 1 1 START domain DUF3074 PF11274.8 EMC89788.1 - 0.12 12.3 0.0 0.43 10.5 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3074) Ten1_2 PF15490.6 EMC89789.1 - 5.7e-42 142.2 0.0 6.3e-42 142.0 0.0 1.0 1 0 0 1 1 1 1 Telomere-capping, CST complex subunit SH3_10 PF17902.1 EMC89790.1 - 6.5e-20 71.0 0.1 1.7e-19 69.7 0.1 1.8 1 0 0 1 1 1 1 SH3 domain Spectrin PF00435.21 EMC89790.1 - 0.00089 19.7 7.4 0.0029 18.1 2.3 12.1 10 4 1 11 11 11 4 Spectrin repeat Sulfotransfer_2 PF03567.14 EMC89790.1 - 3.2 7.6 11.7 0.57 10.0 2.1 3.4 2 0 0 2 2 2 0 Sulfotransferase family DUF4810 PF16068.5 EMC89790.1 - 4.2 8.0 10.0 0.82 10.3 0.1 5.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4810) SRP68 PF16969.5 EMC89791.1 - 3.8e-155 518.1 13.6 4.3e-155 517.9 13.6 1.0 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 TPR_6 PF13174.6 EMC89791.1 - 0.00074 20.0 2.7 0.72 10.6 0.1 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMC89791.1 - 0.049 13.5 3.5 1.1 9.2 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF5340 PF17275.2 EMC89791.1 - 0.2 11.8 6.1 0.77 9.9 0.3 3.5 3 0 0 3 3 3 0 Family of unknown function (DUF5340) FRP PF18032.1 EMC89791.1 - 0.21 12.2 2.4 2.5 8.8 0.1 2.9 2 0 0 2 2 2 0 Photoprotection regulator fluorescence recovery protein TPR_2 PF07719.17 EMC89791.1 - 0.22 11.7 11.4 0.41 10.9 0.3 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat GCOM2 PF15328.6 EMC89791.1 - 0.75 10.1 6.4 0.23 11.8 2.2 2.2 2 0 0 2 2 2 0 Putative GRINL1B complex locus protein 2 7tm_1 PF00001.21 EMC89792.1 - 2.5e-54 184.4 23.1 3.1e-54 184.0 23.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 EMC89792.1 - 1.8e-13 50.5 18.6 3.8e-12 46.1 18.6 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.9 EMC89792.1 - 3.2e-11 43.1 21.5 4e-11 42.8 21.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 EMC89792.1 - 1.2e-06 28.1 20.8 1.7e-06 27.6 20.8 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 EMC89792.1 - 8.8e-06 25.7 20.1 2.7e-05 24.1 20.1 1.7 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC89792.1 - 6.3e-05 22.7 21.8 0.00013 21.7 21.8 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx SecG PF03840.14 EMC89792.1 - 0.061 13.4 0.8 2.5 8.3 0.0 3.3 3 0 0 3 3 3 0 Preprotein translocase SecG subunit Flavi_capsid PF01003.19 EMC89792.1 - 0.14 11.9 0.1 0.3 10.8 0.1 1.6 1 0 0 1 1 1 0 Flavivirus capsid protein C SNARE PF05739.19 EMC89792.1 - 1.4 9.0 9.0 0.76 9.8 0.2 3.2 3 0 0 3 3 3 0 SNARE domain Exo70 PF03081.15 EMC89793.1 - 3.9e-84 282.9 3.8 3.9e-84 282.9 3.8 1.8 2 0 0 2 2 2 1 Exo70 exocyst complex subunit Sec34 PF04136.15 EMC89793.1 - 0.0012 18.8 2.7 0.0049 16.8 2.2 2.3 2 0 0 2 2 2 1 Sec34-like family COG5 PF10392.9 EMC89793.1 - 0.023 14.8 0.7 0.023 14.8 0.7 2.5 3 0 0 3 3 3 0 Golgi transport complex subunit 5 COG6 PF06419.11 EMC89793.1 - 0.035 12.3 12.4 0.26 9.4 2.1 2.2 2 0 0 2 2 2 0 Conserved oligomeric complex COG6 Vps52 PF04129.12 EMC89793.1 - 0.037 12.8 5.4 0.34 9.6 1.3 2.3 2 0 0 2 2 2 0 Vps52 / Sac2 family DUF148 PF02520.17 EMC89793.1 - 0.057 13.5 0.3 0.057 13.5 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF148 DUF4404 PF14357.6 EMC89793.1 - 0.072 13.7 0.5 1.5 9.5 0.1 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4404) MTD PF01993.18 EMC89793.1 - 0.075 12.3 0.0 0.16 11.2 0.0 1.5 1 0 0 1 1 1 0 methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase Sep15_SelM PF08806.11 EMC89793.1 - 0.11 12.6 0.0 0.35 11.1 0.0 1.9 1 0 0 1 1 1 0 Sep15/SelM redox domain RolB_RolC PF02027.17 EMC89793.1 - 0.13 11.9 1.1 0.5 10.0 1.1 2.1 1 1 0 1 1 1 0 RolB/RolC glucosidase family Fib_alpha PF08702.10 EMC89793.1 - 0.4 10.9 3.4 0.35 11.0 0.4 2.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Sec20 PF03908.13 EMC89793.1 - 0.75 9.8 3.3 1.1 9.2 1.3 2.4 3 0 0 3 3 3 0 Sec20 Forkhead PF00250.18 EMC89794.1 - 9.3e-37 125.2 0.1 1.9e-36 124.2 0.1 1.5 1 0 0 1 1 1 1 Forkhead domain zf-C3HC4_3 PF13920.6 EMC89795.1 - 3.4e-14 52.4 9.6 6.6e-14 51.5 9.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMC89795.1 - 7.3e-07 28.9 10.2 1.6e-06 27.8 10.2 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EMC89795.1 - 1.8e-05 25.0 11.5 4.9e-05 23.6 11.5 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EMC89795.1 - 0.0012 18.8 9.9 0.0031 17.4 9.9 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EMC89795.1 - 0.013 15.3 11.5 0.032 14.1 11.5 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EMC89795.1 - 0.23 11.3 3.7 0.38 10.5 0.9 2.8 3 0 0 3 3 3 0 RING-like zinc finger zf-RING_4 PF14570.6 EMC89795.1 - 1.1 9.1 8.3 2.8 7.8 8.3 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-P11 PF03854.14 EMC89795.1 - 2.2 8.0 11.4 2.4 7.9 9.6 2.1 2 0 0 2 2 2 0 P-11 zinc finger V-set PF07686.17 EMC89797.1 - 0.0084 16.3 0.0 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain LRR19-TM PF15176.6 EMC89797.1 - 0.018 15.0 0.4 0.03 14.3 0.4 1.3 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain Septin PF00735.18 EMC89798.1 - 1.8e-111 371.9 2.4 2.2e-111 371.6 2.4 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EMC89798.1 - 1.2e-09 38.2 0.5 4e-09 36.6 0.1 2.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC89798.1 - 9.2e-07 28.9 0.2 6.2e-06 26.2 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 EMC89798.1 - 4.5e-05 22.9 0.1 7.4e-05 22.2 0.1 1.3 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.27 EMC89798.1 - 5.3e-05 22.8 1.0 0.00037 20.1 0.2 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EMC89798.1 - 0.00013 22.1 2.0 0.016 15.3 0.8 2.5 1 1 1 2 2 2 1 Dynamin family ABC_tran PF00005.27 EMC89798.1 - 0.00014 22.4 0.1 0.0083 16.6 0.0 2.4 2 0 0 2 2 2 1 ABC transporter Roc PF08477.13 EMC89798.1 - 0.00016 21.9 0.1 0.00033 20.8 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMC89798.1 - 0.00043 19.9 0.0 0.0011 18.6 0.0 1.7 1 0 0 1 1 1 1 Ras family AAA_16 PF13191.6 EMC89798.1 - 0.0019 18.6 0.0 0.0039 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EMC89798.1 - 0.0058 16.9 0.0 0.012 15.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain G-alpha PF00503.20 EMC89798.1 - 0.0073 15.5 1.3 0.014 14.6 1.1 1.5 1 1 0 1 1 1 1 G-protein alpha subunit IIGP PF05049.13 EMC89798.1 - 0.0079 15.3 0.1 0.051 12.6 0.0 2.1 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) AAA_24 PF13479.6 EMC89798.1 - 0.0083 15.9 0.3 0.03 14.1 0.0 2.0 3 0 0 3 3 3 1 AAA domain FtsK_SpoIIIE PF01580.18 EMC89798.1 - 0.018 14.4 0.0 0.035 13.4 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family NB-ARC PF00931.22 EMC89798.1 - 0.023 13.9 0.1 0.036 13.2 0.1 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_29 PF13555.6 EMC89798.1 - 0.04 13.7 0.0 0.079 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 EMC89798.1 - 0.046 13.2 0.0 0.09 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 EMC89798.1 - 0.062 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein PduV-EutP PF10662.9 EMC89798.1 - 0.07 12.9 0.3 0.43 10.3 0.1 2.1 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 EMC89798.1 - 0.076 12.4 0.2 0.48 9.7 0.1 2.0 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region Arf PF00025.21 EMC89798.1 - 0.11 12.0 0.1 0.21 11.0 0.1 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family Ploopntkinase3 PF18751.1 EMC89798.1 - 0.15 11.9 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 FeoB_N PF02421.18 EMC89798.1 - 0.16 11.5 0.1 0.41 10.2 0.1 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B Sigma54_activat PF00158.26 EMC89798.1 - 0.18 11.5 0.0 0.35 10.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain TNRC6-PABC_bdg PF16608.5 EMC89799.1 - 1.1e-129 432.3 39.6 1.1e-129 432.3 39.6 7.3 6 2 0 7 7 7 1 TNRC6-PABC binding domain M_domain PF12938.7 EMC89799.1 - 5.7e-67 226.1 42.3 5.7e-67 226.1 42.3 6.7 4 1 2 7 7 7 1 M domain of GW182 Ago_hook PF10427.9 EMC89799.1 - 2.2e-20 73.8 27.7 2.2e-20 73.8 27.7 10.9 2 2 5 7 7 7 1 Argonaute hook UBA PF00627.31 EMC89799.1 - 4.7e-06 26.4 0.1 9.2e-06 25.5 0.1 1.5 1 0 0 1 1 1 1 UBA/TS-N domain RRM_1 PF00076.22 EMC89799.1 - 0.00014 21.6 0.0 0.00024 20.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMC89799.1 - 0.012 15.5 0.0 0.027 14.3 0.0 1.6 1 0 0 1 1 1 0 Occluded RNA-recognition motif DUF2748 PF10871.8 EMC89799.1 - 0.57 8.8 4.6 1.5 7.4 1.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2748) THOC7 PF05615.13 EMC89799.1 - 3.2 8.0 8.2 5.8 7.2 8.2 1.3 1 0 0 1 1 1 0 Tho complex subunit 7 Ras PF00071.22 EMC89800.1 - 1.2e-33 116.0 0.0 4.8e-33 114.0 0.0 1.7 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EMC89800.1 - 1.2e-16 61.1 0.0 1.5e-16 60.7 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC89800.1 - 1.3e-07 31.2 0.0 1.5e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EMC89800.1 - 9e-06 25.2 0.0 1.3e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EMC89800.1 - 1e-05 25.6 0.0 1.5e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC89800.1 - 0.00018 21.5 0.1 0.02 14.8 0.0 2.1 1 1 1 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EMC89800.1 - 0.00041 19.9 0.0 0.19 11.2 0.0 2.5 1 1 2 3 3 3 2 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EMC89800.1 - 0.0024 18.3 0.3 0.0084 16.5 0.3 1.9 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EMC89800.1 - 0.0069 16.7 0.1 0.037 14.3 0.1 2.2 1 1 0 1 1 1 1 AAA domain G-alpha PF00503.20 EMC89800.1 - 0.011 14.9 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit NACHT PF05729.12 EMC89800.1 - 0.032 14.1 0.0 0.11 12.4 0.0 1.7 2 0 0 2 2 2 0 NACHT domain AAA_7 PF12775.7 EMC89800.1 - 0.034 13.7 0.0 0.051 13.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Viral_helicase1 PF01443.18 EMC89800.1 - 0.042 13.6 0.0 0.064 13.0 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ATPase_2 PF01637.18 EMC89800.1 - 0.05 13.5 0.1 0.068 13.1 0.1 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Gtr1_RagA PF04670.12 EMC89800.1 - 0.074 12.4 0.0 0.095 12.0 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_28 PF13521.6 EMC89800.1 - 0.091 13.0 0.0 0.2 11.9 0.0 1.6 2 0 0 2 2 2 0 AAA domain PRELI PF04707.14 EMC89801.1 - 5.7e-45 152.9 1.1 8.7e-45 152.4 1.1 1.3 1 0 0 1 1 1 1 PRELI-like family CRAL_TRIO PF00650.20 EMC89801.1 - 4.9e-41 140.1 0.0 8.2e-41 139.4 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EMC89801.1 - 7.2e-06 26.1 0.1 1.9e-05 24.7 0.1 1.8 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Glyco_transf_18 PF15024.6 EMC89802.1 - 2.2e-247 822.2 0.0 2.6e-247 821.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 18 UNC-93 PF05978.16 EMC89803.1 - 2.3e-51 173.6 15.1 2.3e-51 173.6 15.1 2.7 4 0 0 4 4 4 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 EMC89803.1 - 6.5e-12 45.0 38.8 4.3e-10 39.1 23.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily OAD_gamma PF04277.13 EMC89803.1 - 0.026 15.1 0.3 0.17 12.5 0.1 2.5 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain RRM_1 PF00076.22 EMC89804.1 - 8.4e-20 70.4 0.0 1.2e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EMC89804.1 - 0.015 15.3 0.0 0.023 14.7 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Methyltransf_16 PF10294.9 EMC89806.1 - 9e-18 64.6 0.0 1.1e-17 64.3 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase MLD PF11647.8 EMC89807.1 - 0.051 13.9 0.0 0.064 13.6 0.0 1.2 1 0 0 1 1 1 0 Membrane Localization Domain Glyco_transf_29 PF00777.18 EMC89808.1 - 1.6e-77 260.6 0.1 2.2e-77 260.1 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Glyco_transf_29 PF00777.18 EMC89809.1 - 8.1e-70 235.3 0.0 9.9e-70 235.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Globin PF00042.22 EMC89810.1 - 2.2e-25 89.4 0.1 3.3e-25 88.8 0.1 1.3 1 0 0 1 1 1 1 Globin Rhomboid_SP PF12595.8 EMC89811.1 - 5.8e-88 293.9 3.2 9e-88 293.2 3.2 1.3 1 0 0 1 1 1 1 Rhomboid serine protease Rhomboid PF01694.22 EMC89811.1 - 1e-10 41.8 0.2 1e-10 41.8 0.2 1.6 2 0 0 2 2 2 1 Rhomboid family Peptidase_A8 PF01252.18 EMC89811.1 - 0.18 12.0 0.0 0.35 11.1 0.0 1.4 1 0 0 1 1 1 0 Signal peptidase (SPase) II Acetyltransf_1 PF00583.25 EMC89812.1 - 1e-13 51.5 0.0 1.3e-13 51.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMC89812.1 - 3.9e-08 33.3 0.0 5.2e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMC89812.1 - 4.8e-06 26.9 0.0 7.4e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DAGK_cat PF00781.24 EMC89813.1 - 2.8e-25 88.4 0.0 3.8e-25 87.9 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Pribosyl_synth PF14572.6 EMC89814.1 - 3.6e-101 336.8 0.8 3.6e-101 336.8 0.8 1.5 2 0 0 2 2 2 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 EMC89814.1 - 1.3e-38 131.5 0.2 2.7e-38 130.5 0.2 1.5 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EMC89814.1 - 1.7e-06 27.6 0.1 4.5e-06 26.3 0.1 1.7 1 0 0 1 1 1 1 Phosphoribosyl transferase domain DUF4795 PF16043.5 EMC89815.1 - 0.0079 15.8 0.4 0.0079 15.8 0.4 3.6 3 2 0 3 3 3 2 Domain of unknown function (DUF4795) Bac_GDH PF05088.12 EMC89815.1 - 0.046 11.2 1.7 0.037 11.5 0.2 1.5 2 0 0 2 2 2 0 Bacterial NAD-glutamate dehydrogenase Img2 PF05046.14 EMC89815.1 - 0.1 12.9 0.1 0.63 10.4 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial large subunit ribosomal protein (Img2) DUF5635 PF18685.1 EMC89815.1 - 0.46 10.5 0.1 0.46 10.5 0.1 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF5635) CTU2 PF10288.9 EMC89815.1 - 0.82 9.9 5.8 12 6.1 5.8 2.3 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 7tm_1 PF00001.21 EMC89816.1 - 1.3e-46 159.1 24.2 1.7e-46 158.7 24.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 EMC89816.1 - 0.00092 18.6 22.1 0.75 9.0 22.1 2.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw DUF4729 PF15866.5 EMC89816.1 - 1.3 8.3 4.0 0.35 10.2 0.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4729) 7tm_1 PF00001.21 EMC89817.1 - 1.6e-21 76.8 5.0 1.9e-21 76.6 5.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 EMC89817.1 - 0.00045 19.6 1.8 0.00062 19.2 1.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw O-ag_pol_Wzy PF14296.6 EMC89817.1 - 0.0032 16.2 4.3 0.0055 15.4 3.6 1.6 1 1 1 2 2 2 1 O-antigen polysaccharide polymerase Wzy Anticodon_1 PF08264.13 EMC89817.1 - 0.021 14.8 0.3 0.044 13.7 0.2 1.7 1 1 0 1 1 1 0 Anticodon-binding domain of tRNA DUF443 PF04276.12 EMC89817.1 - 0.027 14.3 0.9 0.043 13.6 0.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF443) DUF1129 PF06570.11 EMC89817.1 - 0.098 12.1 0.3 0.15 11.5 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) DUF2975 PF11188.8 EMC89817.1 - 8.9 6.2 7.0 26 4.7 7.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2975) 2OG-FeII_Oxy_3 PF13640.6 EMC89818.1 - 0.018 15.9 0.1 0.038 14.9 0.1 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Glyco_hydro_20 PF00728.22 EMC89819.1 - 6.2e-08 32.4 0.1 8.2e-08 32.0 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain DUF4564 PF15169.6 EMC89820.1 - 1.7e-82 275.6 0.0 2e-82 275.4 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4564) UbiA PF01040.18 EMC89820.1 - 0.027 13.8 0.0 0.037 13.3 0.0 1.1 1 0 0 1 1 1 0 UbiA prenyltransferase family Fe_hyd_lg_C PF02906.14 EMC89821.1 - 1.1e-64 218.4 0.1 4.6e-45 154.2 0.0 2.3 2 0 0 2 2 2 2 Iron only hydrogenase large subunit, C-terminal domain Fe_hyd_SSU PF02256.17 EMC89821.1 - 9.4e-09 35.2 0.0 2.3e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 Iron hydrogenase small subunit Forkhead PF00250.18 EMC89823.1 - 5.9e-41 138.6 0.2 1e-40 137.9 0.2 1.4 1 0 0 1 1 1 1 Forkhead domain ANAPC4_WD40 PF12894.7 EMC89825.1 - 7.4e-06 26.2 0.0 0.031 14.6 0.0 3.7 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF1513 PF07433.11 EMC89825.1 - 0.085 11.9 0.0 0.17 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1513) PHTB1_N PF14727.6 EMC89825.1 - 0.089 12.1 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 PTHB1 N-terminus DUF3761 PF12587.8 EMC89825.1 - 0.17 12.3 0.1 0.43 11.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3761) WD40 PF00400.32 EMC89825.1 - 0.3 12.0 8.0 0.74 10.8 0.2 4.0 3 2 2 5 5 5 0 WD domain, G-beta repeat Ras PF00071.22 EMC89826.1 - 8.6e-41 139.2 0.0 1.2e-40 138.8 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC89826.1 - 2.3e-21 76.2 0.0 3.4e-21 75.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC89826.1 - 4.9e-06 26.1 0.0 6.7e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SOCS_box PF07525.16 EMC89826.1 - 5.9e-05 23.3 1.6 0.00012 22.3 1.6 1.6 1 0 0 1 1 1 1 SOCS box Fructosamin_kin PF03881.14 EMC89827.1 - 8.4e-70 235.2 0.4 3.5e-69 233.2 0.4 1.7 1 1 0 1 1 1 1 Fructosamine kinase APH PF01636.23 EMC89827.1 - 2.5e-08 34.1 0.0 3.2e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF4763 PF15960.5 EMC89827.1 - 0.041 13.2 0.0 0.063 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) RIO1 PF01163.22 EMC89827.1 - 0.18 11.4 0.0 4.5 6.8 0.0 2.1 2 0 0 2 2 2 0 RIO1 family Fructosamin_kin PF03881.14 EMC89828.1 - 4.4e-75 252.6 0.1 1.5e-74 250.8 0.1 1.7 1 1 0 1 1 1 1 Fructosamine kinase APH PF01636.23 EMC89828.1 - 1e-14 55.1 0.0 1.5e-14 54.5 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 EMC89828.1 - 0.00074 18.9 0.1 0.00096 18.5 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EMC89828.1 - 0.0045 16.6 0.0 0.061 12.9 0.0 2.1 2 0 0 2 2 2 1 RIO1 family TFCD_C PF12612.8 EMC89829.1 - 1.2e-67 227.4 0.2 2.8e-66 223.0 0.0 3.2 4 0 0 4 4 4 1 Tubulin folding cofactor D C terminal HEAT_EZ PF13513.6 EMC89829.1 - 2.6e-09 37.4 2.4 0.18 12.3 0.0 6.9 6 1 0 6 6 6 2 HEAT-like repeat HEAT PF02985.22 EMC89829.1 - 0.00032 20.7 7.9 0.41 11.0 0.0 7.3 9 0 0 9 9 9 1 HEAT repeat HEAT_2 PF13646.6 EMC89829.1 - 0.0014 19.0 3.9 3.2 8.2 0.0 5.1 5 2 0 5 5 5 2 HEAT repeats Cnd1 PF12717.7 EMC89829.1 - 0.0058 16.7 0.2 3.1 7.8 0.0 4.4 5 0 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 STAG PF08514.11 EMC89829.1 - 0.012 15.5 0.8 6.7 6.7 0.0 3.0 2 0 0 2 2 2 0 STAG domain Pro_3_hydrox_C PF05373.11 EMC89829.1 - 0.14 12.3 0.1 3.2 7.9 0.0 2.9 3 0 0 3 3 3 0 L-proline 3-hydroxylase, C-terminal HEAT_PBS PF03130.16 EMC89829.1 - 0.39 11.5 5.0 32 5.6 0.0 5.6 7 0 0 7 7 7 0 PBS lyase HEAT-like repeat Glycos_transf_2 PF00535.26 EMC89830.1 - 5.4e-21 75.2 0.0 8.5e-21 74.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EMC89830.1 - 5.4e-06 26.5 0.0 6.5e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 EMC89830.1 - 2.1e-05 25.0 0.0 0.00032 21.2 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 EMC89830.1 - 0.0016 17.9 0.0 0.0024 17.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 NTR PF01759.21 EMC89832.1 - 0.0079 16.0 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 UNC-6/NTR/C345C module TIMP PF00965.17 EMC89832.1 - 0.1 12.4 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Tissue inhibitor of metalloproteinase Herpes_teg_N PF04843.12 EMC89833.1 - 0.063 13.0 0.0 0.063 13.0 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus tegument protein, N-terminal conserved region Sulfotransfer_1 PF00685.27 EMC89834.1 - 1.4e-31 110.0 0.0 1.6e-31 109.7 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC89834.1 - 1.4e-10 41.9 0.0 2.1e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_2 PF03567.14 EMC89834.1 - 0.008 16.1 0.0 0.071 13.0 0.0 2.0 2 0 0 2 2 2 1 Sulfotransferase family UbiA PF01040.18 EMC89835.1 - 6.6e-56 189.4 14.0 9.1e-56 189.0 14.0 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF4007 PF13182.6 EMC89835.1 - 0.052 12.7 0.0 0.079 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4007) DUF1616 PF07760.11 EMC89835.1 - 0.091 12.1 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) Sulfotransfer_1 PF00685.27 EMC89836.1 - 2.7e-39 135.3 0.0 3.3e-39 135.0 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC89836.1 - 1.7e-13 51.5 0.0 5.1e-10 40.1 0.0 2.1 1 1 1 2 2 2 2 Sulfotransferase family Sulfotransfer_2 PF03567.14 EMC89836.1 - 0.011 15.6 0.0 0.082 12.8 0.0 2.0 2 0 0 2 2 2 0 Sulfotransferase family DUF3751 PF12571.8 EMC89838.1 - 0.1 12.7 0.0 0.12 12.5 0.0 1.1 1 0 0 1 1 1 0 Phage tail-collar fibre protein PMP22_Claudin PF00822.20 EMC89840.1 - 6.4e-45 153.0 17.0 7.1e-45 152.8 17.0 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC89840.1 - 6.8e-08 32.5 13.2 6.8e-08 32.5 13.2 1.8 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction DUF2723 PF11028.8 EMC89840.1 - 0.0024 17.8 5.0 0.0024 17.8 5.0 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF2723) DUF3169 PF11368.8 EMC89840.1 - 0.0034 17.0 3.3 0.0034 17.0 3.3 1.4 1 1 1 2 2 2 1 Protein of unknown function (DUF3169) L_HMGIC_fpl PF10242.9 EMC89840.1 - 0.036 14.3 14.2 0.058 13.6 13.8 1.7 1 1 0 1 1 1 0 Lipoma HMGIC fusion partner-like protein T4SS_CagC PF16943.5 EMC89840.1 - 0.11 12.7 0.9 0.24 11.6 0.1 1.9 1 1 1 2 2 2 0 Cag pathogenicity island, type IV secretory system DUF1980 PF09323.10 EMC89840.1 - 0.12 12.3 2.1 0.23 11.3 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1980) DUF2207 PF09972.9 EMC89840.1 - 0.71 8.6 9.8 3.1 6.5 5.0 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF4064 PF13273.6 EMC89840.1 - 1.3 9.3 15.3 0.23 11.8 8.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) MARVEL PF01284.23 EMC89840.1 - 2.7 8.0 16.9 2.2 8.3 6.5 2.2 1 1 0 2 2 2 0 Membrane-associating domain Tektin PF03148.14 EMC89841.1 - 1.4e-152 508.0 25.9 1.5e-152 507.8 25.9 1.0 1 0 0 1 1 1 1 Tektin family BORCS8 PF10167.9 EMC89841.1 - 0.078 12.9 0.9 1.4 8.9 0.0 2.9 3 0 0 3 3 3 0 BLOC-1-related complex sub-unit 8 Sin3_corepress PF08295.12 EMC89841.1 - 0.27 11.4 0.1 0.27 11.4 0.1 3.3 3 0 0 3 3 3 0 Sin3 family co-repressor Chorismate_bind PF00425.18 EMC89841.1 - 0.73 9.3 3.9 0.47 10.0 1.0 2.2 1 1 1 2 2 2 0 chorismate binding enzyme DUF846 PF05832.12 EMC89842.1 - 1.1e-54 184.2 9.6 1.3e-54 184.0 9.6 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) DUF2079 PF09852.9 EMC89842.1 - 0.026 13.4 3.9 0.042 12.7 0.1 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2079) TMEM192 PF14802.6 EMC89842.1 - 0.27 10.3 2.4 0.47 9.5 2.4 1.3 1 0 0 1 1 1 0 TMEM192 family PT PF04886.12 EMC89843.1 - 0.00023 20.6 32.4 2.9e+02 1.1 19.0 4.5 3 1 0 3 3 3 0 PT repeat DUF697 PF05128.12 EMC89844.1 - 0.0026 17.5 0.8 1.1 8.9 0.1 3.0 1 1 2 3 3 3 3 Domain of unknown function (DUF697) DNA_pol_A_exo1 PF01612.20 EMC89845.1 - 1.4e-22 80.2 0.1 6.5e-22 78.1 0.0 2.0 2 0 0 2 2 2 1 3'-5' exonuclease Mut7-C PF01927.16 EMC89845.1 - 8.6e-14 51.9 1.3 1.4e-13 51.2 0.1 1.9 2 0 0 2 2 2 1 Mut7-C RNAse domain Motilin_ghrelin PF04644.12 EMC89845.1 - 0.84 9.5 3.2 3.2 7.6 3.2 2.0 1 0 0 1 1 1 0 Motilin/ghrelin C2 PF00168.30 EMC89849.1 - 3.5e-55 184.6 0.4 6.8e-27 93.8 0.0 2.3 2 0 0 2 2 2 2 C2 domain Comm PF15957.5 EMC89849.1 - 0.0011 19.3 0.0 0.0033 17.7 0.0 1.8 2 0 0 2 2 2 1 Commissureless CEP76-C2 PF15627.6 EMC89849.1 - 0.0015 18.2 0.0 0.79 9.3 0.0 2.3 1 1 1 2 2 2 2 CEP76 C2 domain Shisa PF13908.6 EMC89849.1 - 0.035 14.3 0.0 0.06 13.6 0.0 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF1258 PF06869.12 EMC89849.1 - 0.041 13.4 0.3 0.079 12.4 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1258) DOCK-C2 PF14429.6 EMC89849.1 - 0.054 13.3 0.3 6.2 6.6 0.0 2.2 2 0 0 2 2 2 0 C2 domain in Dock180 and Zizimin proteins MAP17 PF15807.5 EMC89849.1 - 0.056 13.7 0.1 0.14 12.4 0.1 1.6 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 EphA2_TM PF14575.6 EMC89849.1 - 0.073 14.0 0.0 0.17 12.8 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain OAD_gamma PF04277.13 EMC89849.1 - 0.72 10.5 3.1 0.44 11.2 0.6 2.1 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Orthopox_F7 PF05813.12 EMC89849.1 - 0.93 9.6 4.9 2.5 8.2 3.9 2.2 2 0 0 2 2 2 0 Orthopoxvirus F7 protein CLASP_N PF12348.8 EMC89850.1 - 8.4e-41 140.0 8.0 2.3e-36 125.5 0.1 3.3 3 0 0 3 3 3 2 CLASP N terminal HEAT PF02985.22 EMC89850.1 - 1.1e-09 37.7 5.6 0.13 12.6 0.0 7.7 7 0 0 7 7 7 2 HEAT repeat RTP1_C1 PF10363.9 EMC89850.1 - 6.1e-08 32.8 2.2 0.015 15.5 0.1 3.8 3 1 1 4 4 3 2 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 EMC89850.1 - 1.4e-06 28.6 2.5 0.73 10.3 0.3 6.9 6 2 3 9 9 8 1 HEAT repeats HEAT_EZ PF13513.6 EMC89850.1 - 2.9e-06 27.7 0.2 0.04 14.4 0.0 4.7 4 0 0 4 4 4 1 HEAT-like repeat ParcG PF10274.9 EMC89850.1 - 0.0002 21.5 2.2 0.0021 18.2 0.1 2.9 2 1 1 3 3 3 1 Parkin co-regulated protein MMS19_N PF14500.6 EMC89850.1 - 0.00052 19.7 4.2 3.7 7.0 0.1 3.7 3 0 0 3 3 3 2 Dos2-interacting transcription regulator of RNA-Pol-II Adaptin_N PF01602.20 EMC89850.1 - 0.00055 18.6 4.0 0.33 9.5 0.1 4.8 4 1 0 5 5 5 1 Adaptin N terminal region Cnd1 PF12717.7 EMC89850.1 - 0.00093 19.3 8.7 0.0084 16.2 0.7 4.6 5 2 1 6 6 6 1 non-SMC mitotic condensation complex subunit 1 Sec7_N PF12783.7 EMC89850.1 - 0.0011 18.8 7.0 2.6 7.9 1.3 3.9 4 0 0 4 4 4 2 Guanine nucleotide exchange factor in Golgi transport N-terminal TFCD_C PF12612.8 EMC89850.1 - 0.0028 17.5 0.1 0.087 12.7 0.1 3.2 3 0 0 3 3 3 1 Tubulin folding cofactor D C terminal Vac14_Fab1_bd PF12755.7 EMC89850.1 - 0.0038 17.8 1.0 22 5.7 0.0 4.5 4 1 1 5 5 4 0 Vacuolar 14 Fab1-binding region MMS19_C PF12460.8 EMC89850.1 - 0.017 14.3 7.6 0.94 8.5 0.1 3.5 4 0 0 4 4 4 0 RNAPII transcription regulator C-terminal Ipi1_N PF12333.8 EMC89850.1 - 0.027 15.1 2.4 0.37 11.4 0.0 3.5 3 0 0 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation TAN PF11640.8 EMC89850.1 - 0.12 12.5 0.1 0.12 12.5 0.1 3.7 3 1 0 3 3 2 0 Telomere-length maintenance and DNA damage repair LRR_6 PF13516.6 EMC89851.1 - 6.9e-20 69.4 39.0 6.8e-05 22.6 0.1 10.5 12 0 0 12 12 12 5 Leucine Rich repeat LRR_4 PF12799.7 EMC89851.1 - 1.1e-14 54.2 23.6 0.03 14.7 0.8 7.2 4 1 3 8 8 8 7 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EMC89851.1 - 5e-13 48.7 0.4 2.2e-12 46.7 0.4 2.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMC89851.1 - 3.6e-08 33.1 1.8 1e-07 31.7 0.5 2.6 2 0 0 2 2 2 1 F-box domain LRR_1 PF00560.33 EMC89851.1 - 1e-05 25.4 34.0 0.23 12.1 0.1 10.5 10 1 0 10 10 10 2 Leucine Rich Repeat LRR_8 PF13855.6 EMC89851.1 - 0.0026 17.5 18.0 0.48 10.2 2.3 6.1 5 3 1 6 6 6 2 Leucine rich repeat F-box_4 PF15966.5 EMC89851.1 - 0.014 15.2 0.1 0.014 15.2 0.1 2.9 4 0 0 4 4 4 0 F-box Mating_N PF12731.7 EMC89851.1 - 0.052 13.6 0.1 1.7 8.7 0.1 2.6 1 1 0 2 2 2 0 Mating-type protein beta 1 PTE PF02126.18 EMC89851.1 - 0.099 12.1 0.0 11 5.3 0.0 2.5 2 1 0 2 2 2 0 Phosphotriesterase family Xlink PF00193.17 EMC89852.1 - 9.8e-15 54.7 0.4 9.8e-15 54.7 0.4 1.9 2 0 0 2 2 2 1 Extracellular link domain Sushi PF00084.20 EMC89852.1 - 0.00021 21.8 0.7 0.00021 21.8 0.7 2.1 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) GAPT PF11770.8 EMC89852.1 - 0.0042 17.0 0.1 0.0093 15.8 0.1 1.5 1 0 0 1 1 1 1 GRB2-binding adapter (GAPT) SIT PF15330.6 EMC89852.1 - 0.014 15.8 2.3 0.037 14.5 0.2 2.7 3 0 0 3 3 3 0 SHP2-interacting transmembrane adaptor protein, SIT EphA2_TM PF14575.6 EMC89852.1 - 0.051 14.5 0.4 0.14 13.1 0.4 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Ly49 PF08391.10 EMC89852.1 - 0.055 13.8 0.3 0.12 12.7 0.3 1.5 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Insulin_TMD PF17870.1 EMC89852.1 - 0.08 13.0 1.2 0.19 11.8 1.2 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF4366 PF14283.6 EMC89852.1 - 0.11 12.6 2.0 0.15 12.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) DUF3377 PF11857.8 EMC89852.1 - 0.17 11.8 0.1 0.5 10.3 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Fis1_TPR_C PF14853.6 EMC89853.1 - 2.5 8.3 5.8 11 6.1 0.4 2.7 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat LSM PF01423.22 EMC89854.1 - 3.8e-20 71.3 0.5 4.3e-20 71.2 0.5 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EMC89854.1 - 0.081 13.1 0.0 0.091 12.9 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Ribosomal_L32p PF01783.23 EMC89855.1 - 5e-09 36.3 6.7 6.6e-09 35.9 6.7 1.2 1 0 0 1 1 1 1 Ribosomal L32p protein family RecR PF02132.15 EMC89855.1 - 0.00011 21.6 1.0 0.00021 20.8 1.0 1.4 1 0 0 1 1 1 1 RecR protein zf-ribbon_3 PF13248.6 EMC89855.1 - 0.043 13.2 2.0 0.079 12.4 2.0 1.4 1 0 0 1 1 1 0 zinc-ribbon domain DZR PF12773.7 EMC89855.1 - 0.052 13.6 2.7 0.16 12.0 2.8 1.8 1 1 0 1 1 1 0 Double zinc ribbon A2L_zn_ribbon PF08792.10 EMC89855.1 - 0.072 12.8 1.4 0.31 10.8 0.1 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain Proteasome PF00227.26 EMC89856.1 - 5.6e-60 202.1 0.0 8.2e-60 201.6 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EMC89856.1 - 2.8e-10 39.7 0.1 4.9e-10 38.9 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature PBP_dimer PF03717.15 EMC89856.1 - 0.057 13.8 0.0 6.9 7.0 0.0 2.2 2 0 0 2 2 2 0 Penicillin-binding Protein dimerisation domain DUF5614 PF18474.1 EMC89857.1 - 3.4e-124 412.4 0.9 5e-124 411.8 0.9 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5614) DUF1308 PF07000.11 EMC89857.1 - 2.9e-70 235.4 0.0 1.3e-69 233.3 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1308) zf-C2H2 PF00096.26 EMC89859.1 - 3.8e-20 71.2 30.5 0.00035 20.9 0.5 5.7 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC89859.1 - 1.5e-11 44.1 31.0 1.8e-06 28.1 1.4 5.3 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC89859.1 - 5.6e-07 29.9 29.0 0.0053 17.5 0.3 6.0 5 0 0 5 5 5 3 C2H2-type zinc finger FOXP-CC PF16159.5 EMC89859.1 - 2.4e-06 28.1 20.7 0.052 14.2 6.8 5.2 1 1 2 4 4 4 2 FOXP coiled-coil domain zf_ZIC PF18366.1 EMC89859.1 - 0.37 10.9 9.6 2 8.6 0.7 3.7 1 1 2 3 3 3 0 Zic proteins zinc finger domain zf-C2H2_aberr PF17017.5 EMC89859.1 - 1.1 9.4 15.6 10 6.2 2.4 3.5 2 1 1 3 3 3 0 Aberrant zinc-finger PcF PF09461.10 EMC89859.1 - 4.5 7.7 5.5 42 4.6 0.3 3.5 2 1 1 3 3 3 0 Phytotoxin PcF protein TGF_beta PF00019.20 EMC89862.1 - 7.1e-31 107.3 1.2 1.6e-30 106.2 1.2 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 EMC89862.1 - 5.3e-09 36.2 1.2 4.2e-08 33.2 1.2 2.3 1 1 0 1 1 1 1 TGF-beta propeptide CoA_transf_3 PF02515.17 EMC89864.1 - 1.4e-71 241.5 0.1 1.7e-71 241.3 0.1 1.0 1 0 0 1 1 1 1 CoA-transferase family III Pkinase PF00069.25 EMC89866.1 - 1.8e-74 250.5 0.0 2.8e-74 249.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC89866.1 - 1.9e-35 122.4 0.0 3.1e-35 121.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EMC89866.1 - 6.8e-08 31.8 0.3 6.8e-08 31.8 0.3 2.2 3 0 0 3 3 3 1 Haspin like kinase domain Kinase-like PF14531.6 EMC89866.1 - 1.2e-05 24.8 0.0 9.1e-05 21.9 0.0 2.3 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 EMC89866.1 - 0.014 14.7 0.2 0.027 13.8 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMC89866.1 - 0.23 10.2 0.0 0.23 10.2 0.0 2.7 3 0 0 3 3 3 0 Fungal protein kinase THRAP3_BCLAF1 PF15440.6 EMC89866.1 - 0.24 10.4 21.6 0.72 8.8 21.6 1.9 1 0 0 1 1 1 0 THRAP3/BCLAF1 family PDEase_I PF00233.19 EMC89868.1 - 3e-77 259.6 11.4 3.7e-77 259.3 10.2 1.7 2 1 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase PDEase_I_N PF08499.12 EMC89868.1 - 4.3e-31 106.5 0.1 1.2e-30 105.1 0.1 1.8 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase N-terminal MDFI PF15316.6 EMC89869.1 - 1.4e-49 168.4 20.1 1.9e-49 168.1 20.1 1.2 1 0 0 1 1 1 1 MyoD family inhibitor adh_short_C2 PF13561.6 EMC89870.1 - 1.7e-61 207.7 0.7 2.6e-61 207.2 0.7 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMC89870.1 - 7.6e-53 178.9 3.4 4.2e-52 176.4 1.1 2.1 2 0 0 2 2 2 1 short chain dehydrogenase Methyltransf_3 PF01596.17 EMC89870.1 - 1.7e-26 92.7 0.1 2.9e-26 92.0 0.1 1.3 1 0 0 1 1 1 1 O-methyltransferase KR PF08659.10 EMC89870.1 - 3.8e-10 40.0 1.4 5.1e-10 39.6 0.5 1.7 2 0 0 2 2 2 1 KR domain Methyltransf_24 PF13578.6 EMC89870.1 - 0.00047 21.1 0.1 0.0014 19.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain 3Beta_HSD PF01073.19 EMC89870.1 - 0.0027 16.8 1.1 1.1 8.1 0.1 2.2 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 EMC89870.1 - 0.078 13.2 0.8 0.43 10.9 0.2 2.3 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain HTH_6 PF01418.17 EMC89870.1 - 0.15 12.0 1.0 2 8.4 0.0 2.6 3 0 0 3 3 3 0 Helix-turn-helix domain, rpiR family DHQ_synthase PF01761.20 EMC89871.1 - 2.4e-57 194.1 0.0 3e-57 193.8 0.0 1.1 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.6 EMC89871.1 - 2.9e-15 56.7 0.0 1.3e-14 54.5 0.0 1.8 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.19 EMC89871.1 - 1.4e-05 24.1 0.0 2.5e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase SwrA PF17423.2 EMC89871.1 - 0.04 13.9 0.1 0.074 13.0 0.1 1.3 1 0 0 1 1 1 0 Swarming motility protein MITF_TFEB_C_3_N PF15951.5 EMC89872.1 - 1.5e-50 171.8 22.6 1.5e-50 171.8 22.6 2.7 2 1 0 2 2 2 1 MITF/TFEB/TFEC/TFE3 N-terminus DUF3371 PF11851.8 EMC89872.1 - 7.1e-37 127.4 0.7 7.1e-37 127.4 0.7 3.6 2 1 1 3 3 3 1 Domain of unknown function (DUF3371) HLH PF00010.26 EMC89872.1 - 1.9e-16 59.8 0.6 1.9e-16 59.8 0.6 2.0 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain Ribophorin_I PF04597.14 EMC89872.1 - 0.13 11.4 5.9 0.24 10.6 5.9 1.3 1 0 0 1 1 1 0 Ribophorin I 7tm_4 PF13853.6 EMC89873.1 - 1.3e-20 74.3 2.7 1.5e-20 74.1 2.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC89873.1 - 4.4e-05 22.9 5.1 5.8e-05 22.5 5.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1980 PF09323.10 EMC89873.1 - 0.32 10.9 1.5 0.44 10.4 1.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF4515 PF14988.6 EMC89874.1 - 1.3e-16 61.1 16.9 1.3e-16 61.1 16.9 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4515) YafO_toxin PF13957.6 EMC89874.1 - 0.014 15.5 1.1 0.029 14.4 1.1 1.6 1 0 0 1 1 1 0 Toxin YafO, type II toxin-antitoxin system DUF1043 PF06295.12 EMC89874.1 - 2 8.4 22.8 0.31 11.1 14.6 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) DUF4618 PF15397.6 EMC89874.1 - 2.2 7.7 26.4 3.2 7.1 21.8 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) Spectrin PF00435.21 EMC89874.1 - 8.1 7.0 16.6 5.3 7.6 6.3 3.1 2 1 1 3 3 3 0 Spectrin repeat AAA PF00004.29 EMC89875.1 - 2.2e-31 109.0 0.5 4.6e-31 108.0 0.1 1.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMC89875.1 - 2.5e-09 36.8 0.1 6.6e-09 35.4 0.0 1.8 2 0 0 2 2 2 1 AAA+ lid domain Vps4_C PF09336.10 EMC89875.1 - 4.8e-06 26.5 0.0 9.2e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain P66_CC PF16563.5 EMC89875.1 - 0.056 13.1 0.3 0.056 13.1 0.3 1.8 2 0 0 2 2 2 0 Coiled-coil and interaction region of P66A and P66B with MBD2 Peptidase_M28 PF04389.17 EMC89876.1 - 1.4e-48 165.3 0.0 1.7e-48 164.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M28 Get5_C PF18514.1 EMC89876.1 - 0.16 11.8 0.2 0.39 10.5 0.2 1.7 1 0 0 1 1 1 0 Get5 C-terminal domain Pkinase PF00069.25 EMC89877.1 - 1.5e-70 237.6 0.0 2.5e-70 236.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC89877.1 - 6.6e-33 114.1 0.0 1e-32 113.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 EMC89877.1 - 1.6e-28 98.3 18.9 2.9e-14 52.7 3.0 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.29 EMC89877.1 - 1.3e-09 38.5 0.6 2.4e-07 31.2 0.1 3.3 2 1 0 3 3 3 1 PH domain Kinase-like PF14531.6 EMC89877.1 - 2.4e-07 30.4 0.0 3.4e-06 26.6 0.0 2.5 2 1 0 3 3 3 1 Kinase-like C1_2 PF03107.16 EMC89877.1 - 1.3e-05 25.4 15.0 0.0095 16.2 1.6 2.6 2 0 0 2 2 2 2 C1 domain Kdo PF06293.14 EMC89877.1 - 2e-05 24.1 0.0 3.9e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RING_9 PF13901.6 EMC89877.1 - 0.073 13.0 12.2 1.1 9.2 0.4 2.5 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon APH PF01636.23 EMC89877.1 - 0.13 12.2 0.0 1.3 8.9 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.22 EMC89877.1 - 0.13 11.8 0.2 0.26 10.9 0.2 1.4 1 0 0 1 1 1 0 RIO1 family Pox_ser-thr_kin PF05445.11 EMC89877.1 - 0.13 11.2 0.0 0.25 10.3 0.0 1.4 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PHD PF00628.29 EMC89877.1 - 0.18 11.7 16.4 1.5 8.7 3.2 2.6 2 0 0 2 2 2 0 PHD-finger FYVE_2 PF02318.16 EMC89877.1 - 0.84 9.9 10.3 4.7 7.5 5.2 2.8 2 0 0 2 2 2 0 FYVE-type zinc finger Methyltransf_28 PF02636.17 EMC89878.1 - 1.1e-74 251.4 0.0 1.5e-74 250.9 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase RrnaAD PF00398.20 EMC89878.1 - 0.029 13.5 0.0 0.34 10.0 0.0 2.0 2 0 0 2 2 2 0 Ribosomal RNA adenine dimethylase CBF PF03914.17 EMC89879.1 - 1.3e-55 188.1 0.6 1.3e-55 188.1 0.6 2.8 2 0 0 2 2 2 1 CBF/Mak21 family Cnd1 PF12717.7 EMC89879.1 - 0.29 11.2 2.9 0.27 11.3 1.0 1.9 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 DUF2553 PF10830.8 EMC89879.1 - 0.52 11.2 4.1 1.2 10.0 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2553) Sulfotransfer_1 PF00685.27 EMC89881.1 - 2.4e-60 204.3 0.0 3.2e-60 203.9 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMC89881.1 - 9.6e-07 29.4 0.0 3.3e-06 27.6 0.0 1.7 1 1 1 2 2 2 1 Sulfotransferase family DUF1266 PF06889.11 EMC89881.1 - 0.11 12.5 0.1 0.21 11.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1266) VWC PF00093.18 EMC89882.1 - 2e-40 136.9 248.8 7.8e-11 42.1 14.3 15.4 9 2 6 15 15 15 7 von Willebrand factor type C domain Antistasin PF02822.14 EMC89882.1 - 3.3e-16 59.6 62.8 1.2e-06 29.0 10.8 15.0 15 2 1 16 16 16 4 Antistasin family TILa PF12714.7 EMC89882.1 - 0.0011 18.9 26.8 0.0017 18.3 5.9 13.1 11 2 3 14 14 14 5 TILa domain Amnionless PF14828.6 EMC89882.1 - 0.0045 15.9 13.4 0.0045 15.9 13.4 9.0 10 1 1 11 11 11 6 Amnionless FEZ PF07763.13 EMC89883.1 - 2.2e-88 296.0 14.8 2.8e-88 295.7 14.8 1.1 1 0 0 1 1 1 1 FEZ-like protein SCHIP-1 PF10148.9 EMC89883.1 - 0.0018 18.0 0.4 0.0031 17.2 0.4 1.5 1 0 0 1 1 1 1 Schwannomin-interacting protein 1 Gluconate_2-dh3 PF13618.6 EMC89883.1 - 0.06 13.6 0.2 0.12 12.6 0.2 1.5 1 1 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 DUF5102 PF17104.5 EMC89883.1 - 0.14 12.2 10.3 0.32 11.0 8.4 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF5102) EURL PF06937.11 EMC89883.1 - 0.47 9.8 8.5 0.16 11.3 5.5 1.6 1 1 1 2 2 2 0 EURL protein CdiI_2 PF18593.1 EMC89883.1 - 0.58 10.9 6.3 7.5 7.3 0.2 3.0 1 1 2 3 3 3 0 CdiI immunity protein Ribosomal_L12_N PF16320.5 EMC89883.1 - 1.2 8.9 6.3 0.98 9.2 0.9 2.5 2 0 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain V_ATPase_I PF01496.19 EMC89883.1 - 1.5 6.6 7.5 1.8 6.3 7.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NPV_P10 PF05531.12 EMC89883.1 - 2.7 8.5 8.5 11 6.5 0.9 3.4 2 1 2 4 4 4 0 Nucleopolyhedrovirus P10 protein CorA PF01544.18 EMC89883.1 - 2.9 7.1 7.8 2.7 7.3 6.0 1.8 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein 7tm_1 PF00001.21 EMC89884.1 - 1.9e-27 96.2 12.7 2.2e-27 96.0 12.7 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) VWA PF00092.28 EMC89885.1 - 1.6e-81 272.7 1.2 8.3e-43 146.7 0.7 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 EMC89885.1 - 2.7e-33 114.8 0.0 2.5e-15 57.0 0.0 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain LCCL PF03815.19 EMC89885.1 - 6.8e-25 87.0 0.1 1.8e-24 85.7 0.1 1.7 1 0 0 1 1 1 1 LCCL domain VWA_3 PF13768.6 EMC89885.1 - 6.8e-07 29.3 0.0 0.02 14.8 0.0 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_CoxE PF05762.14 EMC89885.1 - 0.00068 19.1 0.0 0.065 12.6 0.0 2.4 2 0 0 2 2 2 1 VWA domain containing CoxE-like protein DUF1194 PF06707.11 EMC89885.1 - 0.00071 18.8 0.1 0.79 8.9 0.0 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF1194) Mucin PF01456.17 EMC89885.1 - 0.0013 18.8 13.1 0.0023 17.9 13.1 1.4 1 0 0 1 1 1 1 Mucin-like glycoprotein Rxt3 PF08642.10 EMC89885.1 - 0.013 16.3 0.1 0.043 14.6 0.1 1.9 1 1 0 1 1 1 0 Histone deacetylation protein Rxt3 WD40 PF00400.32 EMC89886.1 - 3.5e-35 119.4 10.9 3e-08 34.2 0.1 6.9 6 0 0 6 6 6 6 WD domain, G-beta repeat Striatin PF08232.12 EMC89886.1 - 5.3e-27 95.3 3.6 5.3e-27 95.3 3.6 2.8 2 2 0 2 2 2 1 Striatin family ANAPC4_WD40 PF12894.7 EMC89886.1 - 2.9e-08 33.9 0.2 0.022 15.1 0.0 5.5 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 EMC89886.1 - 0.0065 15.3 0.0 5.8 5.5 0.0 3.4 2 2 0 3 3 3 2 Nup133 N terminal like Nup160 PF11715.8 EMC89886.1 - 0.018 13.7 0.0 3.4 6.2 0.0 2.8 3 0 0 3 3 3 0 Nucleoporin Nup120/160 HEAT_2 PF13646.6 EMC89887.1 - 1.5e-09 38.1 10.0 0.052 13.9 0.1 7.3 5 1 1 6 6 6 3 HEAT repeats HEAT PF02985.22 EMC89887.1 - 1.8e-07 30.8 37.6 0.34 11.3 1.4 11.6 11 0 0 11 11 11 3 HEAT repeat Cnd1 PF12717.7 EMC89887.1 - 0.00027 21.0 1.1 37 4.3 0.0 5.4 4 1 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 MMS22L_C PF14911.6 EMC89887.1 - 0.015 14.4 1.5 1 8.3 0.0 2.6 2 0 0 2 2 2 0 S-phase genomic integrity recombination mediator, C-terminal IFRD PF05004.13 EMC89887.1 - 0.021 14.0 13.4 0.53 9.3 1.1 5.8 7 1 0 7 7 7 0 Interferon-related developmental regulator (IFRD) HisKA_3 PF07730.13 EMC89887.1 - 0.073 13.6 0.4 1.7 9.3 0.1 3.4 2 0 0 2 2 2 0 Histidine kinase DnaB_bind PF10410.9 EMC89887.1 - 0.12 12.6 0.0 0.59 10.4 0.0 2.3 2 0 0 2 2 2 0 DnaB-helicase binding domain of primase DUF4187 PF13821.6 EMC89888.1 - 1e-21 76.5 2.3 1e-21 76.5 2.3 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4187) G-patch PF01585.23 EMC89888.1 - 1.2e-14 53.9 1.1 2.2e-14 53.0 1.1 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EMC89888.1 - 2e-06 27.8 0.5 2e-06 27.8 0.5 2.7 2 0 0 2 2 2 1 G-patch domain Yae1_N PF09811.9 EMC89889.1 - 4.3e-09 35.9 38.8 0.0049 16.5 4.6 4.2 1 1 2 3 3 3 3 Essential protein Yae1, N terminal p450 PF00067.22 EMC89890.1 - 1.1e-52 179.3 0.2 1.3e-52 179.1 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 TPR_1 PF00515.28 EMC89891.1 - 6.1e-06 25.8 6.1 0.0077 16.0 1.7 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EMC89891.1 - 0.00033 20.6 3.3 0.079 13.2 0.7 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EMC89891.1 - 0.003 17.5 11.1 0.13 12.5 0.9 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 EMC89891.1 - 0.0046 17.2 1.6 3.7 8.2 0.3 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMC89891.1 - 0.0052 16.4 0.3 0.79 9.5 0.0 3.5 3 0 0 3 3 3 1 TPR repeat TPR_19 PF14559.6 EMC89891.1 - 0.01 16.3 0.9 0.045 14.3 0.0 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat CCDC106 PF15794.5 EMC89891.1 - 0.017 14.8 1.0 0.035 13.8 1.0 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 SKA1 PF07160.12 EMC89891.1 - 0.065 13.1 0.8 0.11 12.3 0.8 1.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 LCD1 PF09798.9 EMC89891.1 - 0.12 10.9 1.3 0.17 10.3 1.3 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein Uds1 PF15456.6 EMC89891.1 - 0.39 10.9 2.9 0.64 10.2 2.5 1.7 1 1 0 1 1 1 0 Up-regulated During Septation BORG_CEP PF14957.6 EMC89892.1 - 1.1e-33 117.0 1.6 1.6e-33 116.5 1.6 1.2 1 0 0 1 1 1 1 Cdc42 effector PBD PF00786.28 EMC89892.1 - 3.6e-09 36.8 0.1 8.6e-09 35.6 0.1 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain NACHT PF05729.12 EMC89893.1 - 2.6e-26 92.5 0.3 1.4e-25 90.1 0.1 2.3 2 0 0 2 2 2 1 NACHT domain NLRC4_HD PF17889.1 EMC89893.1 - 2.3e-20 72.9 3.4 3.2e-20 72.4 1.0 2.6 2 0 0 2 2 2 1 NLRC4 helical domain CARD PF00619.21 EMC89893.1 - 3.3e-17 62.3 2.1 9.4e-17 60.8 0.1 2.8 3 0 0 3 3 3 1 Caspase recruitment domain LRR_8 PF13855.6 EMC89893.1 - 8.1e-06 25.5 11.6 0.088 12.6 0.2 5.4 4 1 0 4 4 4 3 Leucine rich repeat NB-ARC PF00931.22 EMC89893.1 - 0.00015 21.1 0.1 0.00033 19.9 0.1 1.5 1 0 0 1 1 1 1 NB-ARC domain LRR_4 PF12799.7 EMC89893.1 - 0.0022 18.3 24.8 0.23 11.9 0.1 7.3 7 1 1 8 8 8 2 Leucine Rich repeats (2 copies) AAA_30 PF13604.6 EMC89893.1 - 0.0047 16.7 0.0 0.019 14.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain NOD2_WH PF17779.1 EMC89893.1 - 0.015 15.6 0.1 0.083 13.2 0.0 2.4 2 0 0 2 2 2 0 NOD2 winged helix domain AAA_22 PF13401.6 EMC89893.1 - 0.067 13.5 0.0 0.31 11.3 0.0 2.2 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EMC89893.1 - 0.12 12.8 0.0 1.3 9.3 0.1 2.5 2 1 0 2 2 1 0 AAA ATPase domain AAA_19 PF13245.6 EMC89893.1 - 0.19 12.0 1.4 2.6 8.4 0.0 3.0 3 1 1 4 4 4 0 AAA domain LRR_6 PF13516.6 EMC89893.1 - 0.2 11.8 10.7 0.35 11.1 0.1 5.4 5 0 0 5 5 5 0 Leucine Rich repeat BIRC6 PF12356.8 EMC89894.1 - 7.2e-67 224.2 2.6 7.2e-67 224.2 2.6 2.4 3 0 0 3 3 3 1 Baculoviral IAP repeat-containing protein 6 UQ_con PF00179.26 EMC89894.1 - 1.3e-30 105.8 0.0 2.9e-30 104.7 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme BIR PF00653.21 EMC89894.1 - 1.1e-20 74.0 3.0 2.8e-20 72.7 3.0 1.7 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain UEV PF05743.13 EMC89894.1 - 0.00012 21.9 0.0 0.0003 20.6 0.0 1.6 1 0 0 1 1 1 1 UEV domain TPR_2 PF07719.17 EMC89895.1 - 1.5e-16 59.1 17.4 0.00085 19.3 0.0 8.8 8 1 2 10 10 10 3 Tetratricopeptide repeat TPR_1 PF00515.28 EMC89895.1 - 4e-14 51.8 11.2 0.0031 17.2 0.0 7.7 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 EMC89895.1 - 7.9e-12 44.4 13.2 0.00063 19.8 0.0 8.1 8 1 1 9 9 8 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMC89895.1 - 1e-11 44.6 5.7 0.2 12.6 0.1 7.8 4 2 4 8 8 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 EMC89895.1 - 6.1e-11 42.3 0.6 5.3e-07 29.7 0.0 3.6 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMC89895.1 - 1.5e-08 34.2 0.0 0.00021 20.9 0.2 4.8 4 1 1 5 5 5 1 TPR repeat TPR_19 PF14559.6 EMC89895.1 - 2.7e-08 34.2 5.1 0.0011 19.4 0.1 6.6 5 2 1 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 EMC89895.1 - 3.2e-08 33.4 3.9 8.4e-05 22.7 0.0 5.5 6 1 0 6 6 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMC89895.1 - 3.5e-06 27.2 13.2 0.26 11.6 0.5 7.1 4 2 2 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 EMC89895.1 - 5.5e-06 26.9 4.3 0.00053 20.6 0.1 4.4 4 1 1 5 5 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC89895.1 - 5.8e-06 26.4 17.2 0.0088 16.2 0.2 6.0 4 1 2 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EMC89895.1 - 0.00023 21.6 4.9 0.88 10.3 0.0 6.6 8 0 0 8 8 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 EMC89895.1 - 0.00023 21.0 6.2 5.9 7.2 0.3 6.2 5 1 1 6 6 6 1 Tetratricopeptide repeat BTAD PF03704.17 EMC89895.1 - 0.0024 18.3 2.5 0.04 14.3 0.7 3.5 2 2 0 2 2 2 1 Bacterial transcriptional activator domain ChAPs PF09295.10 EMC89895.1 - 0.0063 15.6 0.0 1.1 8.2 0.1 2.5 1 1 1 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_15 PF13429.6 EMC89895.1 - 0.015 14.5 3.3 0.44 9.7 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 EMC89895.1 - 0.026 14.5 3.3 19 5.3 0.0 3.7 3 0 0 3 3 3 0 Putative TPR-like repeat RPN7 PF10602.9 EMC89895.1 - 0.078 12.7 2.1 1.6 8.4 0.0 3.6 4 1 0 4 4 4 0 26S proteasome subunit RPN7 TPR_10 PF13374.6 EMC89895.1 - 0.58 10.1 13.3 9.7 6.2 0.2 6.8 7 1 1 8 8 7 0 Tetratricopeptide repeat DASH_Dam1 PF08653.10 EMC89895.1 - 0.65 9.8 2.5 1.4 8.8 0.3 2.8 4 0 0 4 4 2 0 DASH complex subunit Dam1 Fis1_TPR_C PF14853.6 EMC89895.1 - 2.2 8.4 6.3 7.8 6.7 0.0 4.4 4 1 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat EGF_CA PF07645.15 EMC89896.1 - 9.7e-87 285.0 291.0 9.7e-10 38.5 4.4 19.4 20 2 1 21 21 21 15 Calcium-binding EGF domain TB PF00683.17 EMC89896.1 - 1.2e-49 165.8 75.4 1.4e-16 60.0 9.9 6.6 6 0 0 6 6 6 4 TB domain cEGF PF12662.7 EMC89896.1 - 2.4e-48 161.6 162.3 2.1e-07 30.7 2.6 18.5 18 1 0 18 18 18 12 Complement Clr-like EGF-like EGF PF00008.27 EMC89896.1 - 1.1e-32 111.9 254.7 0.00034 20.8 7.1 19.9 19 0 0 19 19 19 15 EGF-like domain hEGF PF12661.7 EMC89896.1 - 2.7e-18 65.9 223.2 0.00016 22.1 1.9 20.6 19 1 0 19 19 19 13 Human growth factor-like EGF EGF_3 PF12947.7 EMC89896.1 - 1.3e-15 57.2 199.9 0.0023 18.1 1.4 19.5 18 2 0 18 18 18 13 EGF domain Plasmod_Pvs28 PF06247.11 EMC89896.1 - 0.00017 21.8 24.4 0.0014 18.9 3.0 17.3 18 1 0 18 18 18 10 Pvs28 EGF domain FXa_inhibition PF14670.6 EMC89896.1 - 0.00047 20.4 24.0 0.00065 19.9 7.3 19.9 19 2 2 21 21 21 13 Coagulation Factor Xa inhibitory site EGF_MSP1_1 PF12946.7 EMC89896.1 - 0.00074 19.5 1.8 0.00074 19.5 1.8 19.0 23 0 0 23 23 23 7 MSP1 EGF domain 1 RasGEF PF00617.19 EMC89897.1 - 1.3e-45 155.8 0.3 2e-45 155.1 0.3 1.3 1 0 0 1 1 1 1 RasGEF domain C1_1 PF00130.22 EMC89897.1 - 2.4e-13 49.7 9.3 5.6e-13 48.6 9.3 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_7 PF13499.6 EMC89897.1 - 2.4e-09 37.5 1.7 0.00066 20.1 0.1 3.4 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 EMC89897.1 - 2.7e-09 35.9 6.4 0.00018 20.9 0.1 3.4 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EMC89897.1 - 2.8e-09 36.1 1.4 0.0002 21.0 0.1 3.0 2 0 0 2 2 2 2 EF-hand domain RasGEF_N PF00618.20 EMC89897.1 - 2.2e-08 34.3 0.2 7.8e-08 32.5 0.1 2.0 2 0 0 2 2 2 1 RasGEF N-terminal motif EF-hand_5 PF13202.6 EMC89897.1 - 3.5e-07 29.4 6.4 0.0049 16.3 0.0 3.1 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EMC89897.1 - 4e-05 23.4 1.8 0.088 12.7 0.1 2.9 3 0 0 3 3 3 2 EF-hand domain pair DUF2465 PF10239.9 EMC89898.1 - 2.8e-131 437.6 0.0 4e-131 437.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2465) zf-C2H2_jaz PF12171.8 EMC89899.1 - 0.0002 21.5 1.9 0.0002 21.5 1.9 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EMC89899.1 - 0.015 15.6 2.4 2.1 8.7 0.3 2.6 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) EGF PF00008.27 EMC89900.1 - 3.3e-29 100.8 76.5 8.1e-08 32.4 7.3 6.4 6 0 0 6 6 6 6 EGF-like domain hEGF PF12661.7 EMC89900.1 - 1.7e-19 69.6 76.5 9.1e-06 26.1 5.3 7.4 7 0 0 7 7 7 6 Human growth factor-like EGF EGF_2 PF07974.13 EMC89900.1 - 6.2e-08 32.9 98.5 0.0036 17.6 13.5 6.3 6 0 0 6 6 6 5 EGF-like domain EGF_3 PF12947.7 EMC89900.1 - 0.00093 19.3 64.4 0.15 12.3 5.3 6.4 2 2 3 5 5 5 4 EGF domain Laminin_EGF PF00053.24 EMC89900.1 - 0.0025 17.9 76.8 0.042 14.0 12.3 6.4 2 2 3 6 6 6 4 Laminin EGF domain EGF_CA PF07645.15 EMC89900.1 - 0.22 11.8 78.3 0.13 12.5 6.9 6.6 3 1 3 6 6 6 0 Calcium-binding EGF domain Pilt PF15453.6 EMC89901.1 - 2.5e-149 497.7 24.2 1.8e-117 392.9 16.9 2.5 1 1 1 2 2 2 2 Protein incorporated later into Tight Junctions Spc7 PF08317.11 EMC89901.1 - 0.0081 15.1 13.3 0.01 14.8 11.5 2.0 2 1 1 3 3 3 1 Spc7 kinetochore protein HMMR_N PF15905.5 EMC89901.1 - 0.019 14.5 13.3 0.031 13.8 13.3 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Lebercilin PF15619.6 EMC89901.1 - 0.25 11.0 17.7 1.8 8.2 17.7 2.0 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Fib_alpha PF08702.10 EMC89901.1 - 0.64 10.2 6.9 1.1 9.5 5.9 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF641 PF04859.12 EMC89901.1 - 0.66 10.3 7.3 0.18 12.1 2.9 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Syntaxin_2 PF14523.6 EMC89901.1 - 0.88 10.0 5.4 0.81 10.1 2.4 2.3 3 0 0 3 3 2 0 Syntaxin-like protein Exonuc_VII_L PF02601.15 EMC89901.1 - 1.3 8.5 6.0 2.4 7.6 6.0 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.6 EMC89901.1 - 1.5 8.1 5.0 1.3 8.3 3.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.19 EMC89901.1 - 1.5 6.6 5.6 2.2 6.1 5.6 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family OmpH PF03938.14 EMC89901.1 - 1.7 9.0 12.0 0.97 9.8 9.6 1.8 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) HIP1_clath_bdg PF16515.5 EMC89901.1 - 3.7 8.2 15.4 0.37 11.4 10.2 2.0 2 0 0 2 2 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Syntaxin-6_N PF09177.11 EMC89901.1 - 3.8 8.1 11.2 0.64 10.6 2.5 3.0 2 1 1 3 3 3 0 Syntaxin 6, N-terminal Tropomyosin_1 PF12718.7 EMC89901.1 - 4.9 7.3 20.5 8.3 6.6 10.6 2.3 1 1 1 2 2 2 0 Tropomyosin like ATG16 PF08614.11 EMC89901.1 - 5.5 7.2 20.1 0.094 12.9 11.8 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF4795 PF16043.5 EMC89901.1 - 7.8 6.0 12.6 6.2 6.4 10.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) ADIP PF11559.8 EMC89901.1 - 8.8 6.4 17.7 38 4.3 6.1 2.8 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Wtap PF17098.5 EMC89901.1 - 9.3 6.2 13.6 8.7 6.3 10.0 2.5 1 1 1 2 2 2 0 WTAP/Mum2p family TMPIT PF07851.13 EMC89901.1 - 9.8 5.3 7.1 2 7.6 2.9 1.7 1 1 0 1 1 1 0 TMPIT-like protein Yip1 PF04893.17 EMC89902.1 - 1.5e-05 24.8 17.5 2.2e-05 24.2 17.3 1.5 1 1 0 1 1 1 1 Yip1 domain YIF1 PF03878.15 EMC89902.1 - 0.0009 18.8 8.7 0.055 13.0 8.0 2.2 1 1 0 1 1 1 1 YIF1 Romo1 PF10247.9 EMC89902.1 - 0.0095 16.3 0.9 0.028 14.8 0.9 1.9 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 RNA_pol_A_bac PF01000.26 EMC89903.1 - 4.7e-30 104.2 0.0 7.7e-30 103.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EMC89903.1 - 4.8e-22 77.2 0.0 6.4e-22 76.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain INCENP_N PF12178.8 EMC89903.1 - 0.18 11.8 0.5 17 5.5 0.0 2.6 2 0 0 2 2 2 0 Chromosome passenger complex (CPC) protein INCENP N terminal Xpo1 PF08389.12 EMC89904.1 - 1e-32 113.3 2.4 3.5e-32 111.5 2.4 2.1 1 0 0 1 1 1 1 Exportin 1-like protein IBN_N PF03810.19 EMC89904.1 - 6.2e-05 22.8 0.0 0.00023 21.0 0.0 2.1 1 0 0 1 1 1 1 Importin-beta N-terminal domain GTP_EFTU PF00009.27 EMC89905.1 - 2e-26 92.7 0.0 3.3e-26 92.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EMC89905.1 - 3.9e-05 24.0 0.0 0.00018 21.9 0.0 2.2 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EMC89905.1 - 0.00094 19.2 0.0 0.0028 17.7 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC89905.1 - 0.0016 18.4 0.0 0.07 13.0 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase PduV-EutP PF10662.9 EMC89905.1 - 0.0035 17.1 0.1 20 4.9 0.0 3.4 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 EMC89905.1 - 0.027 14.5 0.1 2.2 8.3 0.2 2.4 1 1 1 2 2 2 0 Dynamin family SRPRB PF09439.10 EMC89905.1 - 0.051 13.0 0.2 6.1 6.2 0.0 2.4 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit GTP_EFTU_D3 PF03143.17 EMC89905.1 - 0.08 13.2 0.3 0.19 12.0 0.1 1.8 2 0 0 2 2 2 0 Elongation factor Tu C-terminal domain FeoB_N PF02421.18 EMC89905.1 - 0.083 12.4 0.1 4.4 6.8 0.1 2.8 3 0 0 3 3 3 0 Ferrous iron transport protein B ATP_bind_1 PF03029.17 EMC89905.1 - 0.14 12.0 0.1 11 5.7 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein p31comet PF06581.12 EMC89906.1 - 7.2e-71 238.4 0.0 8.7e-71 238.2 0.0 1.1 1 0 0 1 1 1 1 Mad1 and Cdc20-bound-Mad2 binding EHN PF06441.12 EMC89907.1 - 9.2e-34 116.1 0.4 1.7e-33 115.3 0.4 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EMC89907.1 - 2.8e-23 82.9 0.0 8.2e-23 81.4 0.0 1.8 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMC89907.1 - 9.7e-05 23.1 0.0 0.00025 21.7 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ribosomal_S18 PF01084.20 EMC89908.1 - 4e-16 59.0 0.0 6.7e-16 58.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S18 VEGF_C PF14554.6 EMC89910.1 - 1.1e-29 102.2 20.1 1.1e-29 102.2 20.1 2.6 3 0 0 3 3 3 1 VEGF heparin-binding domain PDGF PF00341.17 EMC89910.1 - 4.8e-26 90.9 5.6 4.8e-26 90.9 5.6 2.4 2 1 0 2 2 2 1 PDGF/VEGF domain DUF3408 PF11888.8 EMC89910.1 - 0.16 12.1 3.2 0.1 12.7 1.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) CXCXC PF03128.14 EMC89910.1 - 0.22 12.0 0.6 0.22 12.0 0.6 3.5 3 0 0 3 3 3 0 CXCXC repeat Ribosomal_L14 PF00238.19 EMC89911.1 - 1.3e-16 60.8 0.0 6.4e-16 58.6 0.0 1.8 1 1 0 1 1 1 1 Ribosomal protein L14p/L23e RSN1_7TM PF02714.15 EMC89912.1 - 5.1e-62 209.7 23.1 1.3e-61 208.4 23.1 1.7 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EMC89912.1 - 4.3e-39 134.5 0.2 6.4e-39 134.0 0.2 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 EMC89912.1 - 2.7e-19 69.5 0.0 2.7e-19 69.5 0.0 5.6 6 1 1 7 7 7 1 Late exocytosis, associated with Golgi transport RRM_1 PF00076.22 EMC89912.1 - 0.085 12.7 0.1 3.9 7.4 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4006 PF13179.6 EMC89912.1 - 8 6.5 7.1 29 4.7 0.5 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF4006) HSP90 PF00183.18 EMC89913.1 - 9.4e-19 67.7 0.0 1.1e-18 67.5 0.0 1.0 1 0 0 1 1 1 1 Hsp90 protein UAA PF08449.11 EMC89914.1 - 2.5e-79 266.6 19.9 3e-79 266.4 19.9 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 EMC89914.1 - 9.6e-08 32.3 21.8 0.0007 19.8 15.3 2.6 2 1 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 EMC89914.1 - 0.068 12.1 17.0 0.21 10.5 4.7 2.1 1 1 0 2 2 2 0 CRT-like, chloroquine-resistance transporter-like DUF983 PF06170.12 EMC89914.1 - 0.17 12.3 3.2 0.79 10.2 3.2 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF983) Ank_2 PF12796.7 EMC89915.1 - 1.7e-27 95.8 0.9 8.7e-14 51.9 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EMC89915.1 - 4.3e-27 93.3 5.8 9.7e-05 22.6 0.0 5.2 5 0 0 5 5 5 5 Ankyrin repeat Ank_3 PF13606.6 EMC89915.1 - 8e-23 78.1 1.5 0.0008 19.7 0.0 5.3 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.6 EMC89915.1 - 2.6e-22 78.9 0.6 1.3e-08 35.2 0.0 3.6 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMC89915.1 - 3e-20 72.0 5.8 5.4e-06 26.6 0.0 5.0 2 2 3 5 5 5 5 Ankyrin repeats (many copies) DUF3447 PF11929.8 EMC89915.1 - 0.027 14.4 0.0 0.051 13.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3447) LRR_6 PF13516.6 EMC89916.1 - 1.8e-20 71.2 30.0 1.2e-05 24.9 0.5 8.2 8 0 0 8 8 8 5 Leucine Rich repeat LRR_4 PF12799.7 EMC89916.1 - 0.00024 21.4 22.4 0.0016 18.8 0.5 6.0 5 1 1 6 6 6 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC89916.1 - 0.0022 18.3 11.0 6.9 7.6 0.0 6.3 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_8 PF13855.6 EMC89916.1 - 0.0084 15.9 21.6 0.15 11.8 1.6 5.9 2 1 2 5 5 5 4 Leucine rich repeat tRNA-synt_2c PF01411.19 EMC89917.1 - 6.9e-164 546.4 0.0 1e-163 545.9 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EMC89917.1 - 2e-08 34.2 0.4 2.1e-07 30.9 0.1 2.5 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 EMC89917.1 - 1.2e-05 25.8 0.5 2.3e-05 24.9 0.0 1.7 2 0 0 2 2 2 1 DHHA1 domain FHA PF00498.26 EMC89918.1 - 2.6e-16 59.7 0.0 4e-16 59.1 0.0 1.3 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EMC89918.1 - 1.7e-05 25.0 0.0 3.2e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain FtsJ PF01728.19 EMC89919.1 - 3.5e-38 131.5 0.0 6.8e-38 130.5 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase G-patch PF01585.23 EMC89919.1 - 8.2e-13 48.0 2.3 2.2e-12 46.6 2.3 1.8 1 0 0 1 1 1 1 G-patch domain WW PF00397.26 EMC89919.1 - 0.00031 20.8 0.8 0.0016 18.5 0.0 2.3 2 0 0 2 2 2 1 WW domain mRNA_cap_enzyme PF01331.19 EMC89919.1 - 0.0027 17.6 0.1 0.007 16.2 0.1 1.6 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain DNA_ligase_A_M PF01068.21 EMC89919.1 - 0.025 14.2 0.0 0.06 13.0 0.0 1.6 1 0 0 1 1 1 0 ATP dependent DNA ligase domain G-patch_2 PF12656.7 EMC89919.1 - 0.033 14.3 1.6 0.09 12.9 1.6 1.7 1 0 0 1 1 1 0 G-patch domain CCDC-167 PF15188.6 EMC89920.1 - 6.2e-15 55.3 1.2 6.5e-15 55.2 1.2 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 167 Ig_3 PF13927.6 EMC89921.1 - 1.1e-71 237.4 15.6 2.1e-12 47.5 0.1 6.7 7 0 0 7 7 6 6 Immunoglobulin domain I-set PF07679.16 EMC89921.1 - 2.4e-62 207.0 0.1 9.6e-12 44.8 0.0 6.4 6 0 0 6 6 6 6 Immunoglobulin I-set domain MAM PF00629.23 EMC89921.1 - 2e-50 170.8 0.0 5.2e-50 169.5 0.0 1.8 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu Ig_2 PF13895.6 EMC89921.1 - 8.9e-49 163.7 5.8 7.4e-08 32.6 0.1 6.6 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.25 EMC89921.1 - 7.1e-48 160.7 3.9 7.1e-09 35.7 0.0 6.6 6 0 0 6 6 6 6 Immunoglobulin domain V-set PF07686.17 EMC89921.1 - 7.3e-26 90.5 16.4 0.0032 17.6 0.1 11.5 7 5 1 8 8 8 5 Immunoglobulin V-set domain Ig_5 PF16681.5 EMC89921.1 - 2.9e-10 40.4 0.0 1.8 9.0 0.0 6.0 5 0 0 5 5 5 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 EMC89921.1 - 2.1e-09 37.3 4.9 0.28 11.3 0.0 5.9 6 0 0 6 6 6 4 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 EMC89921.1 - 6.9e-09 35.1 1.3 0.15 11.7 0.0 6.0 6 0 0 6 6 6 2 Immunoglobulin domain Ig_4 PF16680.5 EMC89921.1 - 7e-09 35.8 0.1 0.82 10.0 0.0 6.1 5 1 0 5 5 5 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 EMC89921.1 - 7.5e-06 25.9 0.9 8.9 6.4 0.0 5.8 6 0 0 6 6 6 1 Izumo-like Immunoglobulin domain C1-set PF07654.15 EMC89921.1 - 6.4e-05 23.3 0.4 1.2 9.6 0.0 4.9 4 0 0 4 4 4 1 Immunoglobulin C1-set domain zf-AN1 PF01428.16 EMC89922.1 - 1.4e-08 34.7 8.0 3.1e-08 33.7 8.0 1.6 1 0 0 1 1 1 1 AN1-like Zinc finger BTB PF00651.31 EMC89923.1 - 9.6e-28 96.6 0.3 4.2e-26 91.4 0.0 2.6 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 EMC89923.1 - 6.1e-24 84.1 0.4 1.5e-22 79.7 0.4 2.4 1 1 1 2 2 2 1 BTB And C-terminal Kelch F5_F8_type_C PF00754.25 EMC89923.1 - 3e-22 79.1 0.0 2.1e-10 40.8 0.0 2.2 2 0 0 2 2 2 2 F5/8 type C domain DUF3342 PF11822.8 EMC89923.1 - 0.019 15.1 0.0 0.98 9.7 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) Tissue_fac PF01108.17 EMC89923.1 - 0.46 10.3 3.8 0.86 9.5 0.8 2.4 2 0 0 2 2 2 0 Tissue factor Glyoxalase PF00903.25 EMC89924.1 - 7.2e-26 90.9 0.0 9.2e-26 90.5 0.0 1.0 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EMC89924.1 - 8.6e-10 38.9 0.0 3.2e-09 37.0 0.0 1.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 EMC89924.1 - 8.1e-07 29.8 0.0 1.2e-06 29.3 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 EMC89924.1 - 0.0032 17.4 0.0 0.43 10.5 0.0 2.2 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_3 PF13468.6 EMC89924.1 - 0.047 13.8 0.0 0.15 12.2 0.0 1.9 2 1 0 2 2 2 0 Glyoxalase-like domain DHC_N1 PF08385.12 EMC89925.1 - 4.1e-164 547.3 10.1 4.1e-164 547.3 10.1 3.5 4 0 0 4 4 4 2 Dynein heavy chain, N-terminal region 1 Staphostatin_A PF09022.10 EMC89925.1 - 0.039 13.8 0.0 0.12 12.2 0.0 1.8 1 0 0 1 1 1 0 Staphostatin A AAA_8 PF12780.7 EMC89926.1 - 1e-94 316.7 0.0 1.9e-94 315.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 EMC89926.1 - 5.8e-85 283.9 6.9 3.8e-82 274.7 4.6 2.6 2 0 0 2 2 2 2 ATP-binding dynein motor region AAA_lid_11 PF18198.1 EMC89926.1 - 6.2e-56 188.7 0.1 1.4e-55 187.6 0.1 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MT PF12777.7 EMC89926.1 - 9.8e-45 153.1 10.3 1.8e-44 152.2 10.3 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 EMC89926.1 - 4.4e-43 146.2 0.1 3.6e-41 140.0 0.1 3.0 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain Dynein_C PF18199.1 EMC89926.1 - 1.8e-22 79.9 4.6 7.4e-21 74.7 0.1 3.7 3 1 0 3 3 3 1 Dynein heavy chain C-terminal domain AAA_5 PF07728.14 EMC89926.1 - 0.075 13.0 0.0 0.21 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) TMF_TATA_bd PF12325.8 EMC89926.1 - 0.18 12.1 23.4 0.011 15.9 6.0 3.9 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding Fez1 PF06818.15 EMC89926.1 - 0.8 10.1 21.2 0.04 14.4 0.5 3.2 3 0 0 3 3 3 0 Fez1 DUF4407 PF14362.6 EMC89926.1 - 1.8 7.8 19.0 1.3 8.3 1.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 EMC89926.1 - 2.2 7.8 11.3 4.3 6.8 1.7 2.9 3 0 0 3 3 3 0 Exonuclease VII, large subunit KxDL PF10241.9 EMC89926.1 - 6 7.2 9.0 7.4 6.9 2.6 3.2 2 0 0 2 2 2 0 Uncharacterized conserved protein UPF0242 PF06785.11 EMC89926.1 - 9.9 6.2 19.3 1.1 9.3 5.0 3.0 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus 7tm_2 PF00002.24 EMC89927.1 - 7.1e-81 271.1 24.1 1.1e-80 270.5 24.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 EMC89927.1 - 7.5e-16 58.2 3.5 7.5e-16 58.2 3.5 1.8 2 0 0 2 2 2 1 Hormone receptor domain Dicty_CAR PF05462.11 EMC89927.1 - 7.7e-06 25.2 16.7 1.4e-05 24.3 16.7 1.4 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Ion_trans_2 PF07885.16 EMC89928.1 - 2.6e-30 104.2 19.6 8.5e-18 64.1 2.0 2.3 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 EMC89928.1 - 0.0051 16.1 9.9 0.018 14.3 0.4 2.3 2 1 0 2 2 2 2 Ion transport protein Ion_trans_2 PF07885.16 EMC89929.1 - 1.7e-29 101.6 11.7 1.3e-15 57.2 1.4 2.3 2 0 0 2 2 2 2 Ion channel IRK PF01007.20 EMC89929.1 - 0.24 11.2 0.0 0.24 11.2 0.0 3.0 2 1 1 3 3 3 0 Inward rectifier potassium channel transmembrane domain Lig_chan PF00060.26 EMC89929.1 - 0.29 11.0 0.1 0.29 11.0 0.1 1.6 2 0 0 2 2 2 0 Ligand-gated ion channel Ion_trans_2 PF07885.16 EMC89930.1 - 2.5e-34 117.0 15.0 1.8e-18 66.2 0.2 2.8 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 EMC89930.1 - 1.7e-05 24.2 10.1 4.3e-05 22.9 0.8 2.2 2 0 0 2 2 2 2 Ion transport protein Kinesin PF00225.23 EMC89931.1 - 5e-72 242.6 0.7 5e-72 242.6 0.7 2.0 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EMC89931.1 - 0.0007 19.6 0.2 0.017 15.1 0.0 2.7 2 0 0 2 2 2 1 Microtubule binding FH2 PF02181.23 EMC89932.1 - 4.2e-111 371.7 13.0 4.2e-111 371.7 13.0 2.7 3 0 0 3 3 3 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 EMC89932.1 - 2.1e-61 207.0 3.6 2.1e-61 207.0 3.6 4.7 4 2 2 6 6 6 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 EMC89932.1 - 6.6e-52 175.8 0.1 6.6e-52 175.8 0.1 3.7 4 0 0 4 4 4 1 Diaphanous GTPase-binding Domain SIP1 PF04938.12 EMC89932.1 - 0.081 12.6 2.3 14 5.3 0.5 3.3 3 0 0 3 3 3 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) DUF2703 PF10865.8 EMC89932.1 - 0.088 13.0 2.0 5.6 7.2 0.5 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF2703) HemX PF04375.14 EMC89932.1 - 2.9 7.1 15.7 0.57 9.4 7.2 3.1 3 0 0 3 3 3 0 HemX, putative uroporphyrinogen-III C-methyltransferase FlaC_arch PF05377.11 EMC89932.1 - 8.2 6.9 14.9 1.9 9.0 0.1 4.5 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) SMN PF06003.12 EMC89932.1 - 9.4 5.4 22.4 1 8.6 16.6 2.1 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) MoaC PF01967.21 EMC89933.1 - 1.5e-53 180.6 0.8 2.4e-53 179.9 0.8 1.3 1 0 0 1 1 1 1 MoaC family Mob_synth_C PF06463.13 EMC89933.1 - 1.6e-40 138.0 0.0 2.7e-40 137.2 0.0 1.4 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 EMC89933.1 - 3.6e-33 115.3 0.1 1.2e-32 113.6 0.1 1.8 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 EMC89933.1 - 1.8e-09 38.0 0.0 3.9e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 EMC89933.1 - 6.2e-06 26.3 0.0 1.9e-05 24.8 0.0 1.8 1 0 0 1 1 1 1 4Fe-4S single cluster domain LRR_8 PF13855.6 EMC89935.1 - 3.8e-38 129.1 41.5 1.7e-12 46.9 3.3 3.5 1 1 3 4 4 4 4 Leucine rich repeat I-set PF07679.16 EMC89935.1 - 6.2e-15 55.0 0.0 1.4e-14 53.9 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain LRR_4 PF12799.7 EMC89935.1 - 2.2e-13 50.1 22.9 5.6e-06 26.6 1.6 4.7 2 2 2 4 4 4 3 Leucine Rich repeats (2 copies) Ig_3 PF13927.6 EMC89935.1 - 2.8e-13 50.3 0.1 1.1e-12 48.4 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain LRR_5 PF13306.6 EMC89935.1 - 1.4e-11 44.4 0.0 1.3e-10 41.4 0.0 2.2 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) ig PF00047.25 EMC89935.1 - 8e-10 38.8 0.0 1.6e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain fn3 PF00041.21 EMC89935.1 - 2.7e-07 30.8 0.5 1.2e-06 28.8 0.0 2.4 3 0 0 3 3 2 1 Fibronectin type III domain LRR_9 PF14580.6 EMC89935.1 - 9.3e-07 28.5 5.9 0.0002 20.9 0.6 2.3 1 1 1 2 2 2 2 Leucine-rich repeat Ig_2 PF13895.6 EMC89935.1 - 8.6e-06 26.0 0.2 5.4e-05 23.4 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain LRR_1 PF00560.33 EMC89935.1 - 0.00019 21.5 17.1 1.9 9.3 0.7 6.8 6 1 1 7 7 6 2 Leucine Rich Repeat Ig_C17orf99 PF17736.1 EMC89935.1 - 0.0012 18.9 0.0 0.035 14.1 0.0 2.5 2 0 0 2 2 2 1 C17orf99 Ig domain LRRCT PF01463.24 EMC89935.1 - 0.039 14.5 0.0 0.14 12.8 0.0 2.0 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain Bromo_TP PF07524.13 EMC89937.1 - 6.9e-22 77.3 0.3 1.4e-21 76.3 0.0 1.6 2 0 0 2 2 2 1 Bromodomain associated MAGE_N PF12440.8 EMC89937.1 - 1.6 9.5 5.2 7.4 7.3 0.1 2.6 2 1 0 2 2 2 0 Melanoma associated antigen family N terminal PfkB PF00294.24 EMC89941.1 - 6.5e-58 196.4 0.0 7.8e-58 196.2 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EMC89941.1 - 3e-06 26.8 0.0 4.8e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase CoA_binding_2 PF13380.6 EMC89941.1 - 0.012 16.1 0.0 0.13 12.7 0.0 2.2 2 0 0 2 2 2 0 CoA binding domain BRE PF06113.12 EMC89942.1 - 2.4e-140 466.9 0.0 2.8e-140 466.7 0.0 1.0 1 0 0 1 1 1 1 Brain and reproductive organ-expressed protein (BRE) UQ_con PF00179.26 EMC89942.1 - 0.016 14.9 2.8 1.7 8.3 0.1 2.7 3 0 0 3 3 3 0 Ubiquitin-conjugating enzyme Ank PF00023.30 EMC89942.1 - 0.11 13.0 0.1 6.2 7.4 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeat UL17 PF17640.2 EMC89942.1 - 0.12 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized UL17 bZIP_1 PF00170.21 EMC89943.1 - 5.8e-09 35.9 19.7 9.4e-09 35.3 19.7 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMC89943.1 - 1.1e-05 25.3 19.3 2e-05 24.6 19.3 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EMC89943.1 - 3e-05 24.5 14.1 5e-05 23.7 14.1 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor ASD2 PF08687.11 EMC89943.1 - 0.0052 16.4 3.9 0.0073 15.9 3.9 1.2 1 0 0 1 1 1 1 Apx/Shroom domain ASD2 UPF0242 PF06785.11 EMC89943.1 - 0.027 14.6 5.4 0.04 14.0 5.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF5320 PF17253.2 EMC89943.1 - 0.29 12.2 1.6 0.49 11.5 1.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5320) APG6_N PF17675.1 EMC89943.1 - 1.6 9.3 13.9 2.9 8.4 13.9 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region Spc7 PF08317.11 EMC89943.1 - 2.7 6.8 10.6 3.7 6.3 10.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein PEHE PF15275.6 EMC89943.1 - 3.5 8.3 9.5 0.49 11.0 4.9 1.9 2 0 0 2 2 2 0 PEHE domain Pox_G5 PF04599.12 EMC89943.1 - 4.7 6.1 4.3 6.4 5.7 4.3 1.1 1 0 0 1 1 1 0 Poxvirus G5 protein Lipase_GDSL PF00657.22 EMC89944.1 - 6.6e-73 245.0 0.0 3.7e-24 85.8 0.0 3.7 4 0 0 4 4 4 3 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 EMC89944.1 - 2.6e-28 99.7 0.2 1.8e-08 35.0 0.0 4.2 3 1 0 3 3 3 3 GDSL-like Lipase/Acylhydrolase family DUF4278 PF14105.6 EMC89944.1 - 0.26 11.7 3.0 14 6.2 1.6 3.3 2 2 0 2 2 2 0 Domain of unknown function (DUF4278) RecR PF02132.15 EMC89944.1 - 0.34 10.5 2.8 7.6 6.2 0.0 3.6 3 0 0 3 3 3 0 RecR protein Metallophos PF00149.28 EMC89945.1 - 1.4e-38 133.5 0.1 1.6e-38 133.2 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase EF-hand_1 PF00036.32 EMC89946.1 - 5.9e-44 144.4 9.7 3.8e-10 38.6 0.4 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EMC89946.1 - 5.9e-37 126.0 3.0 2.1e-19 69.7 0.8 2.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EMC89946.1 - 4.7e-35 119.2 9.9 4.2e-15 55.3 0.3 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 EMC89946.1 - 6e-32 106.8 5.0 1.1e-09 37.4 0.1 4.4 4 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EMC89946.1 - 7.3e-28 94.8 6.8 1.1e-06 27.8 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 EMC89946.1 - 5.6e-16 58.6 0.2 1.9e-09 37.7 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EMC89946.1 - 1.5e-09 37.7 0.5 4.3e-05 23.4 0.1 2.4 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EMC89946.1 - 5.4e-08 33.2 0.0 0.003 17.9 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 EMC89946.1 - 2.1e-06 28.5 0.0 0.0008 20.3 0.0 2.0 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.13 EMC89946.1 - 9.8e-06 25.5 0.0 0.037 14.0 0.0 3.0 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 EMC89946.1 - 2.1e-05 24.5 0.2 6.9e-05 22.9 0.1 2.0 2 1 0 2 2 2 1 Ca2+ insensitive EF hand Dockerin_1 PF00404.18 EMC89946.1 - 0.00015 21.8 4.3 0.026 14.7 0.3 2.9 1 1 1 2 2 2 2 Dockerin type I domain DUF1103 PF06513.11 EMC89946.1 - 0.00074 19.2 1.6 0.00087 19.0 1.6 1.1 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) Caleosin PF05042.13 EMC89946.1 - 0.00078 19.4 0.8 0.65 9.9 0.0 3.5 1 1 3 4 4 4 1 Caleosin related protein TerB PF05099.13 EMC89946.1 - 0.0018 18.2 0.4 0.49 10.4 0.0 2.1 1 1 1 2 2 2 1 Tellurite resistance protein TerB RNA_pol_Rpb4 PF03874.16 EMC89946.1 - 0.0039 17.5 1.2 1.5 9.2 0.1 2.5 3 0 0 3 3 3 1 RNA polymerase Rpb4 DUF5580 PF17743.1 EMC89946.1 - 0.0052 15.4 0.0 0.0053 15.4 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) SurA_N_2 PF13623.6 EMC89946.1 - 0.0062 16.4 0.7 0.33 10.8 0.2 2.2 1 1 1 2 2 2 1 SurA N-terminal domain Poly_export PF02563.16 EMC89946.1 - 0.0089 16.2 0.1 0.55 10.5 0.0 3.0 1 1 1 2 2 2 1 Polysaccharide biosynthesis/export protein DUF4497 PF14924.6 EMC89946.1 - 0.011 16.2 0.0 0.78 10.2 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4497) EF-hand_14 PF17959.1 EMC89946.1 - 0.019 15.3 0.1 8 6.9 0.0 2.4 1 1 1 2 2 2 0 EF-hand domain SurA_N_3 PF13624.6 EMC89946.1 - 0.043 13.6 0.3 0.65 9.8 0.3 2.0 1 1 1 2 2 2 0 SurA N-terminal domain MotA_activ PF09114.10 EMC89946.1 - 0.047 13.8 0.4 0.78 9.9 0.0 2.3 1 1 0 2 2 2 0 Transcription factor MotA, activation domain Fe_hyd_lg_C PF02906.14 EMC89946.1 - 0.063 12.9 0.5 0.25 11.0 0.5 1.9 1 1 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain TetR_C_7 PF14246.6 EMC89946.1 - 0.066 13.2 0.1 6.8 6.8 0.0 2.7 2 1 1 3 3 3 0 AefR-like transcriptional repressor, C-terminal domain dCache_2 PF08269.11 EMC89946.1 - 0.079 12.1 0.1 6.2 5.9 0.1 2.4 1 1 1 2 2 2 0 Cache domain RuvA_C PF07499.13 EMC89946.1 - 0.1 13.1 0.1 11 6.5 0.0 2.9 3 0 0 3 3 3 0 RuvA, C-terminal domain CMD PF02627.20 EMC89946.1 - 0.18 11.8 0.1 6.2 7.0 0.0 2.5 1 1 1 2 2 2 0 Carboxymuconolactone decarboxylase family RAWUL PF16207.5 EMC89948.1 - 4.8e-15 56.0 0.2 1.2e-14 54.7 0.2 1.7 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_2 PF13923.6 EMC89948.1 - 1.9e-09 37.2 12.7 3.6e-09 36.3 12.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC89948.1 - 3.3e-08 33.3 13.9 3.3e-08 33.3 13.9 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMC89948.1 - 4.6e-06 26.4 11.8 4.6e-06 26.4 11.8 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC89948.1 - 8.1e-06 26.1 11.5 8.1e-06 26.1 11.5 1.7 2 0 0 2 2 1 1 Ring finger domain zf-rbx1 PF12678.7 EMC89948.1 - 6.4e-05 23.2 7.2 6.4e-05 23.2 7.2 1.9 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EMC89948.1 - 0.00025 20.9 15.4 0.0016 18.3 14.8 2.4 1 1 2 3 3 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EMC89948.1 - 0.0042 17.1 10.9 0.0042 17.1 10.9 2.0 2 0 0 2 2 2 1 RING-type zinc-finger Rad60-SLD PF11976.8 EMC89948.1 - 0.0049 16.7 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like zf-Nse PF11789.8 EMC89948.1 - 0.012 15.5 7.8 0.022 14.6 7.8 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 EMC89948.1 - 0.016 15.0 15.0 0.038 13.8 13.3 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 EMC89948.1 - 0.021 14.7 3.5 0.021 14.7 3.5 1.9 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 EMC89948.1 - 0.028 14.4 4.5 0.059 13.4 4.5 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DZR PF12773.7 EMC89948.1 - 0.058 13.4 1.0 0.058 13.4 1.0 1.9 1 1 1 2 2 2 0 Double zinc ribbon ubiquitin PF00240.23 EMC89948.1 - 0.064 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin family zf-C3HC4_4 PF15227.6 EMC89948.1 - 0.066 13.4 14.0 0.17 12.1 14.0 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING CUE PF02845.16 EMC89951.1 - 8.6e-11 41.3 0.0 1.4e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 CUE domain Trypsin_2 PF13365.6 EMC89952.1 - 1.8e-09 38.7 0.5 2.1e-09 38.4 0.5 1.3 1 1 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EMC89952.1 - 0.0023 17.8 0.0 0.0033 17.3 0.0 1.3 1 0 0 1 1 1 1 Trypsin Peptidase_S46 PF10459.9 EMC89952.1 - 0.15 10.7 0.0 0.22 10.2 0.0 1.2 1 0 0 1 1 1 0 Peptidase S46 IRS PF02174.17 EMC89953.1 - 6.6e-30 103.0 1.6 1.2e-14 53.9 0.1 2.4 2 0 0 2 2 2 2 PTB domain (IRS-1 type) Pkinase PF00069.25 EMC89955.1 - 5.3e-69 232.5 0.0 6e-69 232.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC89955.1 - 5.6e-41 140.5 0.0 6.6e-41 140.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC89955.1 - 0.00018 21.0 0.0 0.0037 16.6 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EMC89955.1 - 0.12 12.3 3.2 4.1 7.3 0.4 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family DPPIV_rep PF18811.1 EMC89955.1 - 0.53 10.3 1.8 1.3 9.1 1.8 1.6 1 0 0 1 1 1 0 Dipeptidyl peptidase IV (DPP IV) low complexity region FH2 PF02181.23 EMC89956.1 - 1.8e-92 310.3 7.6 1.8e-92 310.3 7.6 2.0 2 0 0 2 2 2 1 Formin Homology 2 Domain Melibiase_2 PF16499.5 EMC89957.1 - 2e-146 486.6 0.3 2.3e-146 486.4 0.3 1.0 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase PF02065.18 EMC89957.1 - 1.5e-05 24.1 0.0 2.8e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Melibiase Glyco_hydro_97 PF10566.9 EMC89957.1 - 0.0057 16.0 0.0 0.04 13.2 0.0 2.0 2 0 0 2 2 2 1 Glycoside hydrolase 97 DUF5637 PF18687.1 EMC89957.1 - 1.1 9.3 3.8 1.4 9.0 1.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5637) PH PF00169.29 EMC89958.1 - 5.3e-17 62.3 0.0 7.3e-17 61.8 0.0 1.2 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 EMC89958.1 - 1.3e-05 25.3 0.0 2.1e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EMC89958.1 - 0.068 13.6 1.6 1.6 9.2 1.6 2.3 1 1 0 1 1 1 0 Pleckstrin homology domain Strabismus PF06638.11 EMC89958.1 - 0.14 10.8 0.0 0.2 10.3 0.0 1.2 1 0 0 1 1 1 0 Strabismus protein PH_13 PF16652.5 EMC89958.1 - 0.18 11.6 0.0 0.26 11.1 0.0 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain DDDD PF10161.9 EMC89959.1 - 6.7e-32 109.1 0.6 7.2e-32 109.0 0.6 1.0 1 0 0 1 1 1 1 Putative mitochondrial precursor protein Complex1_LYR PF05347.15 EMC89960.1 - 1.9e-11 43.8 0.1 2.9e-11 43.2 0.1 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EMC89960.1 - 0.00027 21.6 0.3 0.00042 21.0 0.3 1.4 1 1 0 1 1 1 1 Complex1_LYR-like Melibiase_2_C PF17450.2 EMC89961.1 - 2.7e-14 53.1 0.0 3.6e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 Alpha galactosidase A C-terminal beta sandwich domain Melibiase_C PF17801.1 EMC89961.1 - 3e-09 36.8 0.0 3.9e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain GRAM PF02893.20 EMC89962.1 - 9.9e-15 54.4 0.0 1.3e-14 54.1 0.0 1.1 1 0 0 1 1 1 1 GRAM domain Vps36_ESCRT-II PF11605.8 EMC89962.1 - 0.088 13.0 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 Septin PF00735.18 EMC89963.1 - 6.5e-116 386.5 1.4 7.5e-116 386.3 1.4 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EMC89963.1 - 3.8e-08 33.4 0.0 6.7e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMC89963.1 - 2.7e-06 27.4 3.6 2.3e-05 24.4 1.3 2.5 2 1 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EMC89963.1 - 1.9e-05 24.3 0.5 0.013 15.0 0.0 2.4 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.16 EMC89963.1 - 3.6e-05 23.2 0.1 6.7e-05 22.3 0.1 1.5 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 EMC89963.1 - 0.00043 20.4 7.2 0.081 13.0 0.8 3.3 2 2 1 3 3 3 2 Dynamin family AAA_16 PF13191.6 EMC89963.1 - 0.00085 19.7 0.0 0.0015 19.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 EMC89963.1 - 0.0011 19.5 0.2 0.0041 17.6 0.0 1.8 2 0 0 2 2 2 1 ABC transporter Roc PF08477.13 EMC89963.1 - 0.0012 19.0 0.2 0.0028 17.8 0.2 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 EMC89963.1 - 0.0016 18.8 0.0 0.0043 17.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain Ras PF00071.22 EMC89963.1 - 0.0043 16.7 0.2 0.014 15.0 0.1 1.9 1 1 0 2 2 2 1 Ras family AAA_24 PF13479.6 EMC89963.1 - 0.0045 16.7 0.2 0.18 11.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EMC89963.1 - 0.0062 15.7 0.9 0.0082 15.4 0.2 1.6 2 0 0 2 2 2 1 NB-ARC domain FtsK_SpoIIIE PF01580.18 EMC89963.1 - 0.0075 15.6 0.8 0.01 15.2 0.1 1.5 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_29 PF13555.6 EMC89963.1 - 0.018 14.8 0.1 0.032 14.0 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain G-alpha PF00503.20 EMC89963.1 - 0.024 13.8 3.6 0.092 11.9 3.7 1.9 1 1 0 1 1 1 0 G-protein alpha subunit Sigma54_activat PF00158.26 EMC89963.1 - 0.031 14.0 0.0 0.059 13.1 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain PduV-EutP PF10662.9 EMC89963.1 - 0.031 14.0 0.1 1.2 8.9 0.0 2.8 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation IIGP PF05049.13 EMC89963.1 - 0.046 12.8 0.8 0.09 11.8 0.1 1.7 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) FeoB_N PF02421.18 EMC89963.1 - 0.049 13.2 0.1 0.11 12.1 0.1 1.6 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_7 PF12775.7 EMC89963.1 - 0.058 12.9 0.1 0.12 11.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF815 PF05673.13 EMC89963.1 - 0.1 11.7 0.1 0.19 10.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RNA_helicase PF00910.22 EMC89963.1 - 0.12 12.8 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.6 EMC89963.1 - 0.16 12.1 0.1 0.51 10.5 0.1 1.8 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 EMC89963.1 - 0.18 11.9 1.0 0.36 10.9 0.2 1.8 2 0 0 2 2 2 0 Helicase HerA, central domain BaffR-Tall_bind PF09256.10 EMC89964.1 - 0.00013 21.6 2.5 0.00031 20.4 2.5 1.6 1 0 0 1 1 1 1 BAFF-R, TALL-1 binding Herpes_gE PF02480.16 EMC89964.1 - 0.01 14.6 0.0 0.015 14.1 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Shisa PF13908.6 EMC89965.1 - 6.7e-36 124.3 1.2 7.1e-36 124.2 1.2 1.0 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Chordopox_A13L PF05961.11 EMC89965.1 - 0.13 12.5 0.2 0.19 12.0 0.2 1.3 1 0 0 1 1 1 0 Chordopoxvirus A13L protein ERK-JNK_inhib PF15002.6 EMC89966.1 - 4.7e-62 209.2 0.0 5.3e-62 209.0 0.0 1.0 1 0 0 1 1 1 1 ERK and JNK pathways, inhibitor DUF2111 PF09884.9 EMC89967.1 - 0.2 11.8 0.0 0.38 10.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2111) Ribosomal_L7Ae PF01248.26 EMC89968.1 - 5.3e-26 90.2 0.1 6.6e-26 89.9 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 EMC89968.1 - 0.00031 20.8 0.1 0.00035 20.6 0.1 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 PELOTA_1 PF15608.6 EMC89968.1 - 0.0069 16.2 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 PELOTA RNA binding domain Ku_N PF03731.15 EMC89970.1 - 5.4e-74 248.6 0.1 1.2e-73 247.6 0.1 1.6 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku PF02735.16 EMC89970.1 - 1.4e-56 191.5 0.3 2.3e-56 190.7 0.3 1.4 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_C PF03730.14 EMC89970.1 - 4.4e-27 94.6 0.5 1.9e-26 92.6 0.5 2.1 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm SAP PF02037.27 EMC89970.1 - 1.1e-10 41.0 0.1 2.5e-10 39.8 0.1 1.7 1 0 0 1 1 1 1 SAP domain TSC22 PF01166.18 EMC89970.1 - 0.27 11.6 0.0 0.27 11.6 0.0 2.1 2 0 0 2 2 2 0 TSC-22/dip/bun family Peptidase_C97 PF05903.14 EMC89971.1 - 2.8e-44 150.6 0.0 3.2e-44 150.4 0.0 1.0 1 0 0 1 1 1 1 PPPDE putative peptidase domain PMM PF03332.13 EMC89972.1 - 8.4e-97 323.3 0.1 9.9e-97 323.0 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase CSD PF00313.22 EMC89973.1 - 1.7e-13 50.2 0.1 2.2e-13 49.8 0.1 1.2 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 EMC89973.1 - 0.0026 17.4 0.0 0.0044 16.7 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease B OB domain RNA_pol_Rbc25 PF08292.12 EMC89974.1 - 7.9e-44 149.0 0.1 1.2e-43 148.4 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 EMC89974.1 - 4.3e-20 71.8 0.1 9.1e-20 70.8 0.0 1.6 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 Aconitase PF00330.20 EMC89975.1 - 3.9e-149 497.6 0.0 4.9e-149 497.3 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EMC89975.1 - 4.3e-46 156.5 0.0 9e-46 155.4 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain PHF5 PF03660.14 EMC89976.1 - 1.5e-40 137.6 14.1 1.7e-40 137.4 14.1 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 EMC89976.1 - 0.056 11.3 8.0 0.057 11.3 8.0 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 bZIP_2 PF07716.15 EMC89977.1 - 9.6e-16 57.6 11.9 9.6e-16 57.6 11.9 1.6 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 EMC89977.1 - 3.2e-06 27.1 7.9 6.1e-06 26.2 7.9 1.5 1 0 0 1 1 1 1 bZIP transcription factor Cnn_1N PF07989.11 EMC89977.1 - 0.011 15.9 0.5 0.026 14.7 0.5 1.7 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 bZIP_Maf PF03131.17 EMC89977.1 - 0.037 14.5 5.4 0.087 13.3 5.4 1.6 1 0 0 1 1 1 0 bZIP Maf transcription factor RanGAP1_C PF07834.11 EMC89978.1 - 4.3e-79 264.3 0.7 7e-79 263.6 0.7 1.3 1 0 0 1 1 1 1 RanGAP1 C-terminal domain LRR_6 PF13516.6 EMC89978.1 - 1.3e-16 59.1 7.3 0.17 12.0 0.0 9.0 9 0 0 9 9 9 4 Leucine Rich repeat LRR_1 PF00560.33 EMC89978.1 - 6.8e-06 25.9 1.2 6.6 7.7 0.1 5.8 6 0 0 6 6 5 1 Leucine Rich Repeat LRR_8 PF13855.6 EMC89978.1 - 2e-05 24.3 0.2 1.8 8.4 0.1 4.9 4 1 0 4 4 4 2 Leucine rich repeat LRR_4 PF12799.7 EMC89978.1 - 0.00018 21.8 6.3 4.3 7.9 0.0 5.2 4 2 2 6 6 6 1 Leucine Rich repeats (2 copies) SDA1 PF05285.12 EMC89978.1 - 0.02 14.3 3.9 0.028 13.8 3.9 1.3 1 0 0 1 1 1 0 SDA1 CPSF100_C PF13299.6 EMC89978.1 - 0.054 13.7 1.5 0.12 12.6 1.5 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal BUD22 PF09073.10 EMC89978.1 - 0.07 12.5 5.4 0.12 11.8 5.4 1.3 1 0 0 1 1 1 0 BUD22 MCR_beta_N PF02783.15 EMC89978.1 - 0.084 12.5 0.1 0.18 11.4 0.1 1.5 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, N-terminal domain Prothymosin PF03247.14 EMC89978.1 - 0.084 13.3 16.6 0.21 12.1 16.6 1.6 1 0 0 1 1 1 0 Prothymosin/parathymosin family Roughex PF06020.11 EMC89978.1 - 0.4 9.7 4.7 0.6 9.2 4.7 1.2 1 0 0 1 1 1 0 Drosophila roughex protein NOA36 PF06524.12 EMC89978.1 - 0.83 8.9 10.7 1.5 8.1 10.7 1.3 1 0 0 1 1 1 0 NOA36 protein Nse4-Nse3_bdg PF15412.6 EMC89978.1 - 0.83 9.8 0.0 0.83 9.8 0.0 2.7 2 1 0 2 2 1 0 Binding domain of Nse4/EID3 to Nse3-MAGE THOC2_N PF16134.5 EMC89978.1 - 1.9 7.0 7.2 8.6 4.9 2.7 2.2 2 0 0 2 2 2 0 THO complex subunit 2 N-terminus Cnd2 PF05786.14 EMC89978.1 - 2.1 6.9 6.2 3 6.4 6.2 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 Sigma70_ner PF04546.13 EMC89978.1 - 4.9 7.0 13.2 13 5.6 13.2 1.6 1 0 0 1 1 1 0 Sigma-70, non-essential region PTPRCAP PF15713.5 EMC89978.1 - 6.2 7.1 13.2 12 6.2 13.2 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated RNA_pol_3_Rpc31 PF11705.8 EMC89978.1 - 7.6 6.7 15.0 87 3.3 14.6 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 CobT PF06213.12 EMC89978.1 - 7.9 5.8 15.5 1.7 8.0 11.9 1.6 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT LRR_8 PF13855.6 EMC89979.1 - 1.2e-22 79.4 0.8 3.2e-12 46.0 0.0 2.1 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EMC89979.1 - 1.9e-11 44.0 2.2 0.00081 19.7 0.0 2.9 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC89979.1 - 2e-07 30.6 0.3 1.4 9.8 0.0 4.1 4 0 0 4 4 4 3 Leucine Rich Repeat LRR_6 PF13516.6 EMC89979.1 - 3.5e-06 26.6 1.5 0.6 10.3 0.0 4.2 4 0 0 4 4 4 2 Leucine Rich repeat LRR_5 PF13306.6 EMC89979.1 - 0.00012 22.0 0.0 0.00014 21.8 0.0 1.1 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC89979.1 - 0.00089 18.8 0.0 0.0011 18.5 0.0 1.0 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 EMC89980.1 - 1.7e-62 207.1 4.1 2.2e-13 49.8 0.0 7.2 2 2 4 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 EMC89980.1 - 1.9e-31 107.6 3.4 0.00033 21.0 0.1 8.5 6 3 1 8 8 8 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC89980.1 - 3.4e-15 56.0 0.0 0.0034 16.9 0.0 5.0 2 1 3 5 5 5 5 Leucine-rich repeat LRR_1 PF00560.33 EMC89980.1 - 2.7e-11 42.4 23.4 5.3 8.0 0.1 14.1 15 1 0 15 15 15 2 Leucine Rich Repeat LRR_6 PF13516.6 EMC89980.1 - 8.9e-06 25.4 8.5 2.7 8.3 0.0 8.9 11 0 0 11 11 11 1 Leucine Rich repeat LRRCT PF01463.24 EMC89980.1 - 0.044 14.3 3.9 4.7 8.0 1.4 3.8 3 0 0 3 3 3 0 Leucine rich repeat C-terminal domain HEV_ORF1 PF02444.16 EMC89980.1 - 0.048 14.2 3.7 0.096 13.3 2.9 2.0 2 0 0 2 2 2 0 Hepatitis E virus ORF-2 (Putative capsid protein) MBT PF02820.18 EMC89981.1 - 2.9e-98 322.2 5.6 1.1e-27 96.2 0.3 4.4 4 0 0 4 4 4 4 mbt repeat HAT_KAT11 PF08214.11 EMC89982.1 - 5.5e-70 236.4 0.2 1.2e-69 235.3 0.2 1.5 1 0 0 1 1 1 1 Histone acetylation protein KIX PF02172.16 EMC89982.1 - 2.1e-40 136.9 0.9 4.6e-40 135.8 0.9 1.6 1 0 0 1 1 1 1 KIX domain Creb_binding PF09030.10 EMC89982.1 - 1.1e-32 113.0 21.3 1.1e-32 113.0 21.3 13.6 6 5 5 11 11 11 1 Creb binding DUF902 PF06001.13 EMC89982.1 - 2.6e-22 79.0 7.8 2.6e-22 79.0 7.8 2.3 2 0 0 2 2 2 1 Domain of Unknown Function (DUF902) Bromodomain PF00439.25 EMC89982.1 - 2.5e-17 62.7 0.1 6e-17 61.5 0.1 1.6 1 0 0 1 1 1 1 Bromodomain ZZ PF00569.17 EMC89982.1 - 5.7e-15 54.8 14.7 5.7e-15 54.8 14.7 3.3 4 0 0 4 4 4 1 Zinc finger, ZZ type zf-TAZ PF02135.16 EMC89982.1 - 3.7e-12 46.5 57.9 2.7e-11 43.7 26.6 3.8 3 0 0 3 3 3 2 TAZ zinc finger KIX_2 PF16987.5 EMC89982.1 - 3.4e-05 23.8 0.4 0.00018 21.4 0.4 2.4 1 0 0 1 1 1 1 KIX domain Npa1 PF11707.8 EMC89982.1 - 0.0017 17.8 0.0 0.0029 17.0 0.0 1.3 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal DREV PF05219.12 EMC89983.1 - 1.1e-135 450.8 0.0 1.3e-135 450.7 0.0 1.0 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_23 PF13489.6 EMC89983.1 - 3.7e-12 46.4 0.0 5.3e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC89983.1 - 5.4e-09 36.7 0.0 8.8e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC89983.1 - 1.3e-06 28.9 0.0 2.4e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC89983.1 - 6.5e-06 26.8 0.0 1.3e-05 25.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC89983.1 - 0.032 14.0 0.0 0.091 12.6 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_PK PF05891.12 EMC89983.1 - 0.075 12.5 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase MTS PF05175.14 EMC89983.1 - 0.1 12.2 0.0 3.2 7.3 0.0 2.4 3 0 0 3 3 3 0 Methyltransferase small domain V-set PF07686.17 EMC89984.1 - 1.9e-07 31.2 0.3 6.6e-07 29.5 0.3 1.8 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 EMC89984.1 - 0.0041 17.3 0.3 0.0067 16.6 0.3 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC89984.1 - 0.0069 17.0 0.1 0.011 16.3 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC89984.1 - 0.013 15.5 0.0 0.017 15.2 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain Ras PF00071.22 EMC89986.1 - 7.7e-51 171.9 0.0 8.8e-51 171.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC89986.1 - 2.9e-19 69.5 0.0 3.9e-19 69.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC89986.1 - 2.2e-05 24.0 0.0 2.7e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC89986.1 - 0.023 14.3 0.0 0.033 13.7 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain CagD PF16567.5 EMC89986.1 - 0.03 14.1 0.0 0.044 13.6 0.0 1.2 1 0 0 1 1 1 0 Pathogenicity island component CagD Sec7 PF01369.20 EMC89987.1 - 1.4e-73 246.5 0.2 1.8e-73 246.1 0.2 1.1 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 EMC89987.1 - 1.8e-28 99.1 0.1 3.7e-28 98.1 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EMC89987.1 - 4e-05 24.0 1.9 7e-05 23.2 0.2 2.3 2 1 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 EMC89987.1 - 0.022 14.8 0.0 0.085 13.0 0.0 2.1 1 1 0 1 1 1 0 PH domain PH_8 PF15409.6 EMC89987.1 - 0.034 14.4 0.0 0.13 12.5 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain GPS2_interact PF15784.5 EMC89987.1 - 0.47 10.9 4.4 0.52 10.8 2.8 1.8 2 0 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain Pkinase PF00069.25 EMC89988.1 - 2.7e-45 154.8 1.6 3.5e-29 102.0 0.1 2.6 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMC89988.1 - 2.4e-24 86.0 1.0 8.3e-18 64.6 0.1 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase DUF641 PF04859.12 EMC89988.1 - 0.0026 18.1 1.0 0.0072 16.7 1.0 1.7 1 0 0 1 1 1 1 Plant protein of unknown function (DUF641) SlyX PF04102.12 EMC89988.1 - 0.0067 17.0 1.6 0.019 15.6 1.6 1.8 1 0 0 1 1 1 1 SlyX P4Ha_N PF08336.11 EMC89988.1 - 0.0097 15.9 1.1 0.025 14.6 1.1 1.7 1 0 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region FTA2 PF13095.6 EMC89988.1 - 0.017 14.8 0.1 1.4 8.5 0.0 2.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EMC89988.1 - 0.024 14.0 0.1 0.065 12.6 0.1 1.7 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF16 PF01519.16 EMC89988.1 - 0.026 15.0 2.6 0.031 14.8 0.5 2.1 2 1 0 2 2 2 0 Protein of unknown function DUF16 TMF_DNA_bd PF12329.8 EMC89988.1 - 0.041 13.9 2.6 0.13 12.2 2.6 1.9 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding FliJ PF02050.16 EMC89988.1 - 0.1 12.8 3.9 0.22 11.8 3.9 1.5 1 0 0 1 1 1 0 Flagellar FliJ protein Csm1_N PF18504.1 EMC89988.1 - 0.14 12.6 2.1 0.35 11.2 2.1 1.6 1 0 0 1 1 1 0 Csm1 N-terminal domain DivIC PF04977.15 EMC89988.1 - 0.34 10.7 3.5 0.34 10.7 1.6 1.9 2 0 0 2 2 2 0 Septum formation initiator TMF_TATA_bd PF12325.8 EMC89988.1 - 0.39 11.0 6.3 0.18 12.0 3.0 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding APH PF01636.23 EMC89988.1 - 0.42 10.5 3.1 0.29 11.0 0.1 2.1 3 0 0 3 3 3 0 Phosphotransferase enzyme family Thioredoxin_16 PF18569.1 EMC89989.1 - 1.9e-37 127.2 0.2 3.3e-37 126.5 0.2 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain GST_C PF00043.25 EMC89989.1 - 6.3e-06 26.3 0.0 1.4e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EMC89989.1 - 2.2e-05 24.4 0.0 5.4e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EMC89989.1 - 0.00018 21.6 0.0 0.001 19.2 0.0 2.1 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EMC89989.1 - 0.0084 15.9 0.0 0.026 14.3 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain MutL_C PF08676.11 EMC89990.1 - 3.8e-31 107.8 0.0 1e-30 106.5 0.0 1.7 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 EMC89990.1 - 2.9e-23 81.8 0.0 2.9e-23 81.8 0.0 2.4 3 0 0 3 3 3 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EMC89990.1 - 3.3e-12 46.4 0.0 8.7e-12 45.0 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EMC89990.1 - 1.3e-05 25.7 0.1 6e-05 23.5 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MORN PF02493.20 EMC89991.1 - 1.3e-38 128.6 82.5 1e-07 31.4 0.3 10.9 11 0 0 11 11 11 10 MORN repeat Tudor_2 PF18104.1 EMC89991.1 - 0.13 12.0 1.7 18 5.1 0.1 3.5 3 0 0 3 3 3 0 Jumonji domain-containing protein 2A Tudor domain DUF1712 PF08217.11 EMC89992.1 - 2.9e-95 320.0 6.9 3.6e-85 286.7 0.5 2.1 1 1 1 2 2 2 2 Fungal domain of unknown function (DUF1712) Methyltransf_20 PF12147.8 EMC89992.1 - 0.019 14.1 0.0 0.029 13.5 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase EF-hand_7 PF13499.6 EMC89993.1 - 7.8e-15 55.1 0.7 1.1e-14 54.6 0.7 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EMC89993.1 - 1.5e-13 49.3 2.6 1.5e-06 27.3 1.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EMC89993.1 - 2.2e-12 45.8 0.6 4.7e-06 26.1 0.2 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 EMC89993.1 - 1.7e-11 43.0 3.1 1.2e-05 24.5 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EMC89993.1 - 1.8e-06 27.7 0.2 0.033 14.0 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EMC89993.1 - 0.038 14.3 0.1 0.072 13.4 0.1 1.5 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Toprim_2 PF13155.6 EMC89993.1 - 0.053 13.9 0.1 5.3 7.5 0.0 2.1 1 1 1 2 2 2 0 Toprim-like DUF3944 PF13099.6 EMC89993.1 - 0.11 12.4 0.7 0.38 10.7 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF3944) EF-hand_10 PF14788.6 EMC89993.1 - 0.41 10.6 2.9 0.82 9.6 0.5 2.4 2 1 0 2 2 2 0 EF hand EF-hand_1 PF00036.32 EMC89994.1 - 2.4e-12 45.5 1.7 5.3e-05 22.5 0.4 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EMC89994.1 - 8.5e-12 45.4 0.0 1.3e-11 44.8 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EMC89994.1 - 4e-11 41.9 1.6 3.6e-05 23.4 0.1 2.9 3 1 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 EMC89994.1 - 6.5e-11 41.2 2.7 2.8e-05 23.4 0.1 2.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EMC89994.1 - 7.2e-07 29.0 0.4 1.7e-05 24.6 0.1 2.3 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EMC89994.1 - 0.0027 18.0 0.0 0.0044 17.3 0.0 1.4 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region HLH PF00010.26 EMC89995.1 - 3.7e-17 62.0 4.1 7.6e-17 61.0 4.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain RepB PF07506.11 EMC89995.1 - 0.024 14.7 2.4 0.034 14.2 2.4 1.2 1 0 0 1 1 1 0 RepB plasmid partitioning protein Hyd_WA PF06462.12 EMC89996.1 - 7.2e-68 224.2 64.2 1.2e-11 44.4 3.2 10.4 12 0 0 12 12 12 8 Propeller Pex24p PF06398.11 EMC89996.1 - 3.4e-21 75.7 22.9 1.8e-12 46.9 3.6 2.2 2 0 0 2 2 2 2 Integral peroxisomal membrane peroxin PH PF00169.29 EMC89996.1 - 0.0026 18.2 1.3 0.0062 17.0 0.4 2.1 2 0 0 2 2 2 1 PH domain DUF2367 PF10164.9 EMC89997.1 - 1.2e-37 128.6 5.9 1.2e-37 128.5 5.9 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2367) DUF4126 PF13548.6 EMC89997.1 - 0.037 13.7 1.3 0.041 13.6 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4126) zf-RING_4 PF14570.6 EMC89997.1 - 0.04 13.7 1.2 4.8 7.0 0.2 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-ribbon_3 PF13248.6 EMC89997.1 - 0.12 11.9 0.2 0.12 11.9 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Rubredoxin_2 PF18073.1 EMC89997.1 - 0.13 12.1 3.3 7.4 6.4 0.0 2.3 2 0 0 2 2 2 0 Rubredoxin metal binding domain zf_Rg PF17915.1 EMC89997.1 - 0.18 11.2 4.5 1.1 8.7 0.3 2.2 2 0 0 2 2 2 0 Reverse gyrase zinc finger DUF1936 PF09151.10 EMC89997.1 - 0.45 10.5 0.4 0.45 10.5 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1936) IMD PF08397.11 EMC89998.1 - 8.3e-51 172.5 5.0 1.7e-50 171.4 5.0 1.5 1 1 0 1 1 1 1 IRSp53/MIM homology domain SH3_9 PF14604.6 EMC89998.1 - 1e-10 41.3 0.0 1.9e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC89998.1 - 2e-06 27.4 0.0 3.9e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC89998.1 - 7.8e-06 25.4 0.0 1.5e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain Rhabdo_M1 PF03342.13 EMC89998.1 - 0.0068 15.8 0.9 0.015 14.7 0.6 1.7 2 0 0 2 2 2 1 Rhabdovirus M1 matrix protein (M1 polymerase-associated protein) BAR_3 PF16746.5 EMC89998.1 - 0.0085 15.8 8.4 0.036 13.8 8.4 1.8 1 1 0 1 1 1 1 BAR domain of APPL family Prominin PF05478.11 EMC89998.1 - 0.046 11.7 0.9 0.061 11.3 0.9 1.1 1 0 0 1 1 1 0 Prominin OrfB_IS605 PF01385.19 EMC89998.1 - 1.8 8.8 6.4 0.44 10.8 0.1 2.3 1 1 1 2 2 2 0 Probable transposase Troponin-I_N PF11636.8 EMC89998.1 - 6.2 6.9 6.7 0.9 9.5 1.1 2.4 2 0 0 2 2 2 0 Troponin I residues 1-32 PKD PF00801.20 EMC89999.1 - 4.3e-07 29.7 2.3 0.04 13.8 0.0 3.6 4 0 0 4 4 4 2 PKD domain Fam20C PF06702.12 EMC90003.1 - 1.2e-107 358.7 0.1 2.1e-107 357.9 0.1 1.4 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 Forkhead PF00250.18 EMC90004.1 - 2.3e-37 127.1 0.2 2.8e-37 126.8 0.2 1.1 1 0 0 1 1 1 1 Forkhead domain DUF3277 PF11681.8 EMC90004.1 - 0.057 13.3 0.0 0.071 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3277) DUF1388 PF07142.12 EMC90005.1 - 1.2e-11 44.4 25.1 0.0039 17.1 0.4 5.4 2 1 2 4 4 4 4 Repeat of unknown function (DUF1388) Ribosomal_S30 PF04758.14 EMC90006.1 - 0.0016 18.6 0.0 0.0024 18.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S30 zf-H2C2_2 PF13465.6 EMC90007.1 - 1.7e-14 53.5 11.4 2.1e-05 24.7 1.1 3.1 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.26 EMC90007.1 - 2.2e-10 40.4 21.3 1.5e-05 25.2 4.0 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC90007.1 - 1.9e-08 34.4 21.0 4.5e-05 23.9 3.7 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC90007.1 - 0.00042 20.2 14.0 0.0044 17.0 1.5 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.7 EMC90007.1 - 0.0015 18.9 2.5 0.0015 18.9 2.5 3.2 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 EMC90007.1 - 0.04 13.8 0.0 0.04 13.8 0.0 3.2 3 1 0 3 3 3 0 zinc-finger of a C2HC-type Spt46 PF17734.1 EMC90007.1 - 0.051 13.4 3.8 0.066 13.0 3.8 1.3 1 1 0 1 1 1 0 Spermatogenesis-associated protein 46 zf-C2H2_11 PF16622.5 EMC90007.1 - 0.11 12.2 17.0 0.24 11.2 3.0 3.1 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 EMC90007.1 - 0.15 12.4 9.9 1 9.7 3.5 2.4 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-RING_2 PF13639.6 EMC90007.1 - 0.66 10.3 10.2 22 5.5 10.4 2.6 1 1 0 1 1 1 0 Ring finger domain Zf_RING PF16744.5 EMC90007.1 - 0.79 9.9 10.5 3.9 7.7 0.4 3.0 1 1 2 3 3 3 0 KIAA1045 RING finger Zn_Tnp_IS1595 PF12760.7 EMC90007.1 - 3.2 7.8 11.5 3.3 7.8 0.3 2.5 2 1 0 2 2 2 0 Transposase zinc-ribbon domain BTB PF00651.31 EMC90008.1 - 4.4e-19 68.7 0.0 5e-19 68.6 0.0 1.0 1 0 0 1 1 1 1 BTB/POZ domain p450 PF00067.22 EMC90009.1 - 1.3e-11 43.9 0.3 1.4e-11 43.9 0.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 HSD3 PF15244.6 EMC90010.1 - 9.8e-35 120.9 15.3 7.8e-19 68.5 8.7 2.1 2 0 0 2 2 2 2 Spermatogenesis-associated protein 7, or HSD3 CENP-F_N PF10481.9 EMC90011.1 - 1.2e-132 442.2 43.7 1.2e-132 442.2 43.7 16.0 6 3 9 15 15 15 2 Cenp-F N-terminal domain CENP-F_leu_zip PF10473.9 EMC90011.1 - 4.2e-47 159.7 64.1 1.6e-39 135.1 36.4 24.8 9 3 16 25 25 25 7 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CENP-F_C_Rb_bdg PF10490.9 EMC90011.1 - 1.1e-05 24.8 0.1 2.2e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 Rb-binding domain of kinetochore protein Cenp-F/LEK1 GIT_CC PF16559.5 EMC90011.1 - 0.0058 16.5 0.6 0.0058 16.5 0.6 22.4 19 8 7 27 27 27 2 GIT coiled-coil Rho guanine nucleotide exchange factor SANT_DAMP1_like PF16282.5 EMC90011.1 - 0.056 13.6 0.1 2.8 8.2 0.2 3.9 2 0 0 2 2 2 0 SANT/Myb-like domain of DAMP1 Y_phosphatase PF00102.27 EMC90012.1 - 9.1e-76 254.5 0.7 1.6e-75 253.7 0.7 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase FERM_M PF00373.18 EMC90012.1 - 5.6e-22 78.4 0.3 2e-21 76.6 0.3 2.0 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.10 EMC90012.1 - 7.3e-19 67.5 0.2 1.9e-18 66.2 0.2 1.8 1 0 0 1 1 1 1 FERM N-terminal domain FERM_C PF09380.10 EMC90012.1 - 4.9e-10 39.7 1.4 1.2e-09 38.4 0.6 2.1 2 0 0 2 2 2 1 FERM C-terminal PH-like domain DSPc PF00782.20 EMC90012.1 - 4.3e-05 23.4 0.0 0.00012 21.9 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC90012.1 - 0.00073 19.6 0.0 0.0016 18.4 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EMC90012.1 - 0.018 15.2 0.3 0.18 11.9 0.0 2.6 2 0 0 2 2 2 0 Inositol hexakisphosphate SET PF00856.28 EMC90014.1 - 2.1e-11 44.5 0.1 4.1e-11 43.6 0.1 1.5 1 0 0 1 1 1 1 SET domain zf-MYND PF01753.18 EMC90014.1 - 2.3e-11 43.6 5.2 2.3e-11 43.6 5.2 1.8 2 0 0 2 2 2 1 MYND finger TPR_12 PF13424.6 EMC90014.1 - 1.6e-05 25.1 0.5 0.00027 21.2 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 EMC90014.1 - 0.00093 19.0 0.4 0.0032 17.3 0.2 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EMC90014.1 - 0.0081 16.3 0.3 0.02 15.1 0.3 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 EMC90014.1 - 0.01 16.6 0.6 0.073 13.9 0.1 2.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EMC90014.1 - 0.046 13.8 1.1 0.66 10.2 0.3 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat HPD PF05044.12 EMC90015.1 - 4.2e-82 273.5 2.2 7.6e-82 272.7 2.2 1.4 1 0 0 1 1 1 1 Homeo-prospero domain NifQ PF04891.12 EMC90015.1 - 0.012 16.0 3.0 0.5 10.7 0.0 3.4 3 0 0 3 3 3 0 NifQ Metal_resist PF13801.6 EMC90015.1 - 0.23 11.6 9.8 0.31 11.2 8.1 2.1 2 0 0 2 2 2 0 Heavy-metal resistance FliD_N PF02465.18 EMC90015.1 - 0.29 11.9 4.4 8.3 7.2 5.6 2.7 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus AATF-Che1 PF13339.6 EMC90015.1 - 0.45 11.2 9.5 2.1 9.1 9.4 2.2 2 1 0 2 2 2 0 Apoptosis antagonizing transcription factor Exonuc_VII_L PF02601.15 EMC90015.1 - 0.67 9.5 6.0 1.3 8.5 6.0 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit FapA PF03961.13 EMC90015.1 - 0.72 8.4 3.3 1.1 7.7 3.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF2968 PF11180.8 EMC90015.1 - 1.1 8.8 15.6 2.1 7.9 15.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) WDCP PF15390.6 EMC90015.1 - 1.9 6.8 8.7 3 6.1 8.7 1.2 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family PP_kinase_N PF13089.6 EMC90015.1 - 2.6 8.4 11.1 4.9 7.5 5.3 3.2 2 1 0 2 2 2 0 Polyphosphate kinase N-terminal domain Nop25 PF09805.9 EMC90015.1 - 3 8.3 18.8 6.4 7.3 18.8 1.6 1 1 0 1 1 1 0 Nucleolar protein 12 (25kDa) DUF4407 PF14362.6 EMC90015.1 - 5.8 6.2 8.4 9 5.5 8.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LETM1 PF07766.13 EMC90016.1 - 2.1e-66 224.0 4.6 3.5e-66 223.3 4.6 1.3 1 0 0 1 1 1 1 LETM1-like protein Pkinase PF00069.25 EMC90017.1 - 3e-29 102.2 0.0 1.3e-25 90.3 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain MIT PF04212.18 EMC90017.1 - 5.9e-18 64.7 2.5 1.1e-17 63.8 2.5 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Pkinase_Tyr PF07714.17 EMC90017.1 - 3.8e-12 46.0 0.0 2.4e-10 40.1 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase PX PF00787.24 EMC90017.1 - 2.4e-11 43.6 0.4 4.5e-11 42.7 0.4 1.5 1 0 0 1 1 1 1 PX domain Kinase-like PF14531.6 EMC90017.1 - 2.8e-05 23.6 0.0 5.1e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC90017.1 - 0.15 11.4 0.1 0.29 10.5 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Exo_endo_phos PF03372.23 EMC90018.1 - 2.7e-24 86.0 0.0 3.8e-24 85.5 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 EMC90018.1 - 0.031 14.1 0.7 0.28 11.0 0.0 2.9 4 0 0 4 4 4 0 Endonuclease-reverse transcriptase MFS_1 PF07690.16 EMC90019.1 - 2.3e-25 89.3 26.7 2.3e-25 89.3 26.7 1.5 1 1 1 2 2 2 2 Major Facilitator Superfamily UL45 PF05473.12 EMC90019.1 - 0.27 10.9 0.1 0.27 10.9 0.1 3.0 3 1 0 3 3 3 0 UL45 protein, carbohydrate-binding C-type lectin-like OATP PF03137.20 EMC90019.1 - 5.1 5.3 16.4 0.088 11.1 7.5 2.3 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family TatD_DNase PF01026.21 EMC90020.1 - 4.9e-48 163.7 0.0 6.5e-48 163.3 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Flexi_CP_N PF08358.10 EMC90020.1 - 0.054 13.5 0.1 0.18 11.8 0.0 1.9 2 0 0 2 2 2 0 Carlavirus coat Mis14 PF08641.12 EMC90021.1 - 9.6e-23 81.0 2.8 1.5e-22 80.3 2.8 1.3 1 0 0 1 1 1 1 Kinetochore protein Mis14 like T3SS_basalb_I PF17001.5 EMC90021.1 - 0.049 14.2 0.1 0.091 13.4 0.1 1.5 1 1 0 1 1 1 0 Type III secretion basal body protein I, YscI, HrpB, PscI bZIP_1 PF00170.21 EMC90022.1 - 3e-12 46.4 12.5 3.8e-12 46.1 12.5 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMC90022.1 - 9.9e-10 38.4 14.2 1.3e-09 38.0 14.2 1.1 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EMC90022.1 - 6.6e-09 36.2 9.5 8.6e-09 35.8 9.5 1.1 1 0 0 1 1 1 1 bZIP Maf transcription factor HALZ PF02183.18 EMC90022.1 - 3.8e-05 23.8 2.4 8e-05 22.8 2.4 1.6 1 0 0 1 1 1 1 Homeobox associated leucine zipper HAP1_N PF04849.13 EMC90022.1 - 0.001 18.3 6.3 0.0012 18.1 6.3 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Baculo_gp64 PF03273.13 EMC90022.1 - 0.0063 15.4 0.9 0.0075 15.1 0.9 1.0 1 0 0 1 1 1 1 Baculovirus gp64 envelope glycoprotein family SYCE1 PF15233.6 EMC90022.1 - 0.0064 16.6 6.4 0.0064 16.6 6.4 1.5 1 1 1 2 2 2 1 Synaptonemal complex central element protein 1 DivIC PF04977.15 EMC90022.1 - 0.0068 16.2 4.7 0.0068 16.2 4.7 1.5 1 1 0 1 1 1 1 Septum formation initiator DUF3450 PF11932.8 EMC90022.1 - 0.0072 15.7 2.7 0.0084 15.4 2.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) CENP-H PF05837.12 EMC90022.1 - 0.013 15.8 4.4 0.017 15.6 4.4 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Phlebovirus_NSM PF07246.11 EMC90022.1 - 0.018 14.5 2.7 0.019 14.4 2.7 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M PM0188 PF11477.8 EMC90022.1 - 0.022 14.0 0.2 0.024 13.8 0.2 1.1 1 0 0 1 1 1 0 Sialyltransferase PMO188 TLE_N PF03920.15 EMC90022.1 - 0.022 14.8 1.9 0.026 14.6 1.9 1.2 1 0 0 1 1 1 0 Groucho/TLE N-terminal Q-rich domain Ribosomal_L30_N PF08079.12 EMC90022.1 - 0.022 15.0 10.5 0.03 14.6 10.5 1.1 1 0 0 1 1 1 0 Ribosomal L30 N-terminal domain Prominin PF05478.11 EMC90022.1 - 0.024 12.6 1.1 0.025 12.5 1.1 1.0 1 0 0 1 1 1 0 Prominin S6OS1 PF15676.5 EMC90022.1 - 0.024 13.1 3.3 0.028 12.9 3.3 1.1 1 0 0 1 1 1 0 Six6 opposite strand transcript 1 family TPD52 PF04201.15 EMC90022.1 - 0.026 14.1 4.4 0.032 13.8 4.3 1.2 1 1 0 1 1 1 0 Tumour protein D52 family Cnn_1N PF07989.11 EMC90022.1 - 0.027 14.6 6.9 0.027 14.6 6.9 1.5 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 AAA_13 PF13166.6 EMC90022.1 - 0.032 12.9 4.6 0.037 12.7 4.6 1.0 1 0 0 1 1 1 0 AAA domain ATG16 PF08614.11 EMC90022.1 - 0.039 14.2 10.4 0.05 13.8 10.4 1.0 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF1465 PF07323.12 EMC90022.1 - 0.043 13.7 4.6 0.051 13.4 4.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) FapA PF03961.13 EMC90022.1 - 0.057 12.0 3.9 0.062 11.9 3.9 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A AAA_11 PF13086.6 EMC90022.1 - 0.058 13.2 2.5 0.068 12.9 2.5 1.0 1 0 0 1 1 1 0 AAA domain DUF812 PF05667.11 EMC90022.1 - 0.077 11.9 6.5 0.093 11.6 6.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF2009 PF09418.10 EMC90022.1 - 0.079 12.0 2.3 0.088 11.9 2.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2009) TMF_DNA_bd PF12329.8 EMC90022.1 - 0.083 12.9 10.2 0.099 12.7 9.8 1.3 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding TMCO5 PF14992.6 EMC90022.1 - 0.085 12.4 5.9 0.097 12.2 5.9 1.1 1 0 0 1 1 1 0 TMCO5 family NYD-SP28_assoc PF14775.6 EMC90022.1 - 0.089 12.9 1.6 0.58 10.3 0.6 2.2 1 1 1 2 2 2 0 Sperm tail C-terminal domain UPF0242 PF06785.11 EMC90022.1 - 0.1 12.7 6.5 0.12 12.5 6.5 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Seryl_tRNA_N PF02403.22 EMC90022.1 - 0.12 12.7 6.2 0.15 12.3 6.2 1.1 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain TMPIT PF07851.13 EMC90022.1 - 0.14 11.4 4.5 0.16 11.2 4.5 1.0 1 0 0 1 1 1 0 TMPIT-like protein JIP_LZII PF16471.5 EMC90022.1 - 0.15 12.2 6.1 0.12 12.6 4.6 1.6 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II Afi1 PF07792.12 EMC90022.1 - 0.17 12.4 2.1 0.18 12.3 2.1 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking ZapB PF06005.12 EMC90022.1 - 0.18 12.3 8.7 0.081 13.4 6.2 1.7 1 1 1 2 2 2 0 Cell division protein ZapB tRNA-synt_2c PF01411.19 EMC90022.1 - 0.18 10.3 2.8 0.21 10.1 2.8 1.0 1 0 0 1 1 1 0 tRNA synthetases class II (A) DUF4407 PF14362.6 EMC90022.1 - 0.19 11.1 2.0 0.21 10.9 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1515 PF07439.11 EMC90022.1 - 0.2 11.7 2.1 0.27 11.3 2.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) V_ATPase_I PF01496.19 EMC90022.1 - 0.24 9.3 2.4 0.25 9.2 2.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family bZIP_1 PF00170.21 EMC90023.1 - 7.3e-12 45.2 18.2 1.4e-11 44.3 18.2 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMC90023.1 - 1.1e-09 38.2 19.2 1.7e-09 37.6 19.2 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EMC90023.1 - 9.3e-08 32.5 7.9 9.3e-08 32.5 7.9 1.6 2 0 0 2 2 2 1 bZIP Maf transcription factor Dapper PF15268.6 EMC90023.1 - 0.0052 15.7 2.8 0.0054 15.7 2.8 1.0 1 0 0 1 1 1 1 Dapper SNAPc19 PF15497.6 EMC90023.1 - 0.013 15.9 1.1 0.013 15.9 1.1 2.1 2 0 0 2 2 2 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 Ribosomal_L6e PF01159.19 EMC90023.1 - 0.047 14.2 6.4 0.11 13.0 6.3 1.6 1 1 1 2 2 2 0 Ribosomal protein L6e Afi1 PF07792.12 EMC90023.1 - 0.11 12.9 3.5 0.17 12.4 3.5 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DivIC PF04977.15 EMC90023.1 - 0.22 11.3 6.8 0.42 10.4 6.8 1.5 1 0 0 1 1 1 0 Septum formation initiator Fungal_TACC PF12709.7 EMC90023.1 - 1 9.9 9.0 1.1 9.7 8.1 1.6 1 1 0 1 1 1 0 Fungal Transforming acidic coiled-coil (TACC) proteins Macoilin PF09726.9 EMC90023.1 - 1.2 7.6 11.8 1.5 7.2 11.8 1.1 1 0 0 1 1 1 0 Macoilin family ALMT PF11744.8 EMC90023.1 - 4.1 6.1 6.3 4.7 5.9 6.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Cyt-b5 PF00173.28 EMC90024.1 - 8.6e-11 41.8 0.0 1.1e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TMEM206 PF15122.6 EMC90025.1 - 1.2e-172 572.8 3.5 1.4e-172 572.6 3.5 1.0 1 0 0 1 1 1 1 TMEM206 protein family Tetraspanin PF00335.20 EMC90025.1 - 0.013 15.3 0.1 0.044 13.5 0.0 1.9 2 0 0 2 2 2 0 Tetraspanin family B56 PF01603.20 EMC90026.1 - 3.8e-191 635.5 10.7 4.5e-191 635.3 10.7 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 EMC90026.1 - 0.047 13.6 3.0 1 9.2 0.2 3.4 2 1 0 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal WD40 PF00400.32 EMC90027.1 - 3.5e-25 87.8 12.9 4.9e-05 24.0 0.1 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC90027.1 - 3.2e-05 24.1 0.3 0.049 13.9 0.1 3.9 2 2 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMC90027.1 - 0.092 11.4 0.1 14 4.1 0.0 2.8 3 0 0 3 3 3 0 Nucleoporin Nup120/160 HEAT_2 PF13646.6 EMC90028.1 - 0.0013 19.1 5.0 0.18 12.2 0.0 4.7 4 1 1 5 5 5 1 HEAT repeats TPR_6 PF13174.6 EMC90028.1 - 0.0013 19.2 1.4 1.7 9.5 0.2 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat Paz_1 PF18349.1 EMC90028.1 - 0.02 14.8 0.0 0.5 10.4 0.0 2.3 2 0 0 2 2 2 0 PAZ domain DUF3453 PF11935.8 EMC90028.1 - 0.044 13.4 7.4 0.057 13.1 0.3 3.5 3 1 0 4 4 4 0 Domain of unknown function (DUF3453) TPR_2 PF07719.17 EMC90028.1 - 0.16 12.1 0.8 8.9 6.7 0.1 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat SPG48 PF14764.6 EMC90028.1 - 0.73 10.3 7.1 0.24 11.9 0.2 3.7 3 2 2 5 5 5 0 AP-5 complex subunit, vesicle trafficking WD40 PF00400.32 EMC90031.1 - 1.2e-25 89.2 11.4 0.011 16.6 0.1 10.7 10 0 0 10 10 10 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC90031.1 - 1.5e-12 47.6 0.0 0.085 13.2 0.0 5.8 4 1 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain DUF5046 PF16465.5 EMC90031.1 - 0.0079 15.7 0.5 0.05 13.1 0.3 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF5046) eIF2A PF08662.11 EMC90031.1 - 0.081 12.8 0.0 0.47 10.3 0.0 2.1 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EMC90031.1 - 0.32 9.6 0.8 5.9 5.4 0.0 2.7 2 1 1 3 3 3 0 Nucleoporin Nup120/160 TFIIS_C PF01096.18 EMC90032.1 - 0.00031 20.5 0.2 0.00031 20.5 0.2 2.2 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EMC90032.1 - 0.0056 16.5 3.1 0.029 14.2 0.2 2.4 2 1 0 2 2 2 1 RNA polymerases M/15 Kd subunit Rubredoxin_2 PF18073.1 EMC90032.1 - 0.42 10.4 4.7 3 7.7 0.2 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain RhoGAP PF00620.27 EMC90034.1 - 2.6e-17 63.1 0.1 5.4e-08 32.8 0.1 2.1 2 0 0 2 2 2 2 RhoGAP domain NSs PF11073.8 EMC90036.1 - 0.044 13.2 0.3 0.059 12.8 0.3 1.2 1 0 0 1 1 1 0 Rift valley fever virus non structural protein (NSs) like TFIIE_beta PF02186.15 EMC90037.1 - 7.1e-22 77.5 0.2 7.1e-22 77.5 0.2 2.3 3 0 0 3 3 3 1 TFIIE beta subunit core domain TFA2_Winged_2 PF18121.1 EMC90037.1 - 2.3e-10 40.0 0.1 5.4e-10 38.8 0.1 1.7 1 0 0 1 1 1 1 TFA2 Winged helix domain 2 PDZ PF00595.24 EMC90037.1 - 0.042 14.2 0.1 0.096 13.0 0.1 1.5 1 0 0 1 1 1 0 PDZ domain EF-hand_11 PF08976.11 EMC90037.1 - 0.047 14.6 0.0 0.084 13.7 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain Hexapep PF00132.24 EMC90038.1 - 3.2e-07 29.8 22.9 0.00059 19.4 3.7 4.8 5 1 0 5 5 5 3 Bacterial transferase hexapeptide (six repeats) PHO4 PF01384.20 EMC90039.1 - 2.6e-139 464.0 8.6 3.2e-139 463.7 8.6 1.1 1 0 0 1 1 1 1 Phosphate transporter family Vpu PF00558.19 EMC90039.1 - 0.024 14.4 0.1 0.024 14.4 0.1 2.0 2 0 0 2 2 2 0 Vpu protein Pkinase_Tyr PF07714.17 EMC90041.1 - 4e-08 32.9 0.0 1e-06 28.2 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EMC90041.1 - 2e-05 24.1 0.0 0.0019 17.6 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain PIP49_C PF12260.8 EMC90041.1 - 0.0019 17.9 0.0 0.003 17.2 0.0 1.2 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 DUF5009 PF16401.5 EMC90042.1 - 9.3e-08 31.9 0.3 9.3e-08 31.9 0.3 3.0 3 1 0 3 3 3 1 Domain of unknown function (DUF5009) DUF1624 PF07786.12 EMC90042.1 - 2.3e-07 30.6 1.2 2.3e-07 30.6 1.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1624) Yae1_N PF09811.9 EMC90043.1 - 9.3e-16 57.3 178.7 1.8e+04 -148.3 178.7 12.3 1 1 0 1 1 1 0 Essential protein Yae1, N terminal Cornifin PF02389.15 EMC90043.1 - 0.032 14.4 64.4 1.8e+04 -36.8 64.4 4.4 1 1 0 1 1 1 0 Cornifin (SPRR) family CHGN PF05679.16 EMC90044.1 - 7.7e-74 249.4 0.0 9.4e-74 249.1 0.0 1.0 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Glyco_transf_7C PF02709.14 EMC90044.1 - 1.7e-09 37.2 0.9 3.9e-09 36.0 0.9 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 EMC90044.1 - 0.0019 17.7 0.2 0.012 15.1 0.2 2.1 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Jnk-SapK_ap_N PF09744.9 EMC90044.1 - 0.039 14.2 1.3 0.074 13.3 1.3 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF4094 PF13334.6 EMC90044.1 - 0.065 13.6 0.0 0.18 12.3 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) Sec8_exocyst PF04048.14 EMC90044.1 - 0.087 12.7 1.3 9 6.2 0.3 2.3 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain Cnn_1N PF07989.11 EMC90044.1 - 0.11 12.6 4.0 0.41 10.8 1.6 2.4 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Mod_r PF07200.13 EMC90044.1 - 0.13 12.3 3.3 0.33 11.1 3.3 1.6 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Pkinase PF00069.25 EMC90045.1 - 9.2e-75 251.4 0.0 1.4e-74 250.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC90045.1 - 2.6e-40 138.3 0.0 1.3e-39 136.0 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC90045.1 - 1.6e-06 27.7 2.3 9.2e-05 21.9 0.0 2.9 2 1 0 3 3 3 1 Kinase-like Haspin_kinase PF12330.8 EMC90045.1 - 3.3e-05 23.0 0.1 6.4e-05 22.1 0.1 1.4 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 EMC90045.1 - 0.00098 18.8 0.1 0.0022 17.6 0.1 1.5 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 EMC90045.1 - 0.0022 17.4 0.1 0.0044 16.4 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMC90045.1 - 0.013 15.5 0.1 0.25 11.2 0.0 2.5 2 1 1 3 3 3 0 Phosphotransferase enzyme family NUC153 PF08159.12 EMC90045.1 - 0.11 12.4 0.4 21 5.1 0.0 3.2 3 0 0 3 3 3 0 NUC153 domain MdcG PF10620.9 EMC90045.1 - 0.13 12.0 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosyl-dephospho-CoA transferase MdcG zinc_ribbon_6 PF14599.6 EMC90046.1 - 2e-28 98.1 0.8 2e-28 98.1 0.8 3.2 2 1 1 3 3 1 1 Zinc-ribbon zf-RING_2 PF13639.6 EMC90046.1 - 1.5e-10 41.2 5.3 1.5e-10 41.2 5.3 4.5 3 2 0 3 3 2 1 Ring finger domain zf-C3HC4 PF00097.25 EMC90046.1 - 1.6e-07 31.0 4.5 1.6e-07 31.0 4.5 4.4 3 1 1 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC90046.1 - 8.5e-07 28.7 5.6 8.5e-07 28.7 5.6 4.5 3 1 1 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC90046.1 - 1.5e-06 28.0 4.5 1.5e-06 28.0 4.5 5.5 2 2 2 4 4 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC90046.1 - 7e-06 25.8 0.4 7e-06 25.8 0.4 5.1 3 3 2 5 5 5 2 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EMC90046.1 - 8.6e-06 25.7 3.3 8.6e-06 25.7 3.3 3.8 4 2 1 5 5 5 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EMC90046.1 - 1.1e-05 25.2 6.1 1.1e-05 25.2 6.1 5.2 2 2 2 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EMC90046.1 - 7.2e-05 22.4 3.1 7.2e-05 22.4 3.1 4.1 3 1 1 4 4 4 1 RING-like zinc finger zf-RING_4 PF14570.6 EMC90046.1 - 0.00015 21.5 2.9 0.00015 21.5 2.9 4.4 4 1 0 4 4 3 1 RING/Ubox like zinc-binding domain zf-UDP PF14569.6 EMC90046.1 - 0.00023 21.2 1.1 0.00023 21.2 1.1 3.0 3 2 0 3 3 3 1 Zinc-binding RING-finger zf-CHY PF05495.12 EMC90046.1 - 0.028 14.9 2.3 0.028 14.9 2.3 4.3 2 1 2 4 4 2 0 CHY zinc finger TMEM154 PF15102.6 EMC90047.1 - 0.00012 22.0 0.1 0.00015 21.7 0.1 1.1 1 0 0 1 1 1 1 TMEM154 protein family EphA2_TM PF14575.6 EMC90047.1 - 0.00027 21.8 0.2 0.00048 20.9 0.2 1.4 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain PAG PF15347.6 EMC90047.1 - 0.00033 19.8 0.2 0.00037 19.6 0.2 1.0 1 0 0 1 1 1 1 Phosphoprotein associated with glycosphingolipid-enriched Vpu PF00558.19 EMC90047.1 - 0.0011 18.6 0.2 0.0017 18.1 0.2 1.2 1 0 0 1 1 1 1 Vpu protein TMEM52 PF14979.6 EMC90047.1 - 0.0035 17.3 1.0 0.0047 16.9 1.0 1.2 1 0 0 1 1 1 1 Transmembrane 52 EGF PF00008.27 EMC90047.1 - 0.0043 17.3 1.6 0.0043 17.3 1.6 2.6 2 1 0 2 2 2 1 EGF-like domain DUF2663 PF10864.8 EMC90047.1 - 0.016 15.6 0.0 0.02 15.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2663) Rax2 PF12768.7 EMC90047.1 - 0.023 14.2 0.0 0.031 13.7 0.0 1.1 1 0 0 1 1 1 0 Cortical protein marker for cell polarity Laminin_EGF PF00053.24 EMC90047.1 - 0.029 14.5 3.7 0.029 14.5 3.7 2.3 2 0 0 2 2 2 0 Laminin EGF domain FAM176 PF14851.6 EMC90047.1 - 0.04 13.6 0.1 0.047 13.3 0.1 1.2 1 0 0 1 1 1 0 FAM176 family AJAP1_PANP_C PF15298.6 EMC90047.1 - 0.041 14.1 1.5 0.061 13.5 1.5 1.2 1 0 0 1 1 1 0 AJAP1/PANP C-terminus LST1 PF05083.13 EMC90047.1 - 0.043 14.1 0.3 0.043 14.1 0.3 1.7 2 0 0 2 2 2 0 LST-1 protein Comm PF15957.5 EMC90047.1 - 0.061 13.7 0.1 0.083 13.2 0.1 1.2 1 0 0 1 1 1 0 Commissureless DAG1 PF05454.11 EMC90047.1 - 0.12 11.7 0.1 0.13 11.6 0.1 1.1 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) TRP PF06011.12 EMC90047.1 - 0.12 11.0 0.2 0.15 10.7 0.2 1.0 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel Sigma_reg_N PF13800.6 EMC90047.1 - 0.14 12.5 0.0 0.18 12.1 0.0 1.2 1 0 0 1 1 1 0 Sigma factor regulator N-terminal ATP1G1_PLM_MAT8 PF02038.16 EMC90048.1 - 3.5e-16 58.4 0.1 5.5e-16 57.7 0.1 1.3 1 0 0 1 1 1 1 ATP1G1/PLM/MAT8 family OAD_gamma PF04277.13 EMC90048.1 - 0.091 13.4 1.6 0.15 12.7 1.6 1.5 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain NUC153 PF08159.12 EMC90049.1 - 0.65 9.9 6.5 2e+02 1.9 0.0 5.1 6 1 1 7 7 7 0 NUC153 domain Plexin_cytopl PF08337.12 EMC90053.1 - 3.5e-221 735.7 11.8 8.8e-221 734.4 11.8 1.7 1 1 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Sema PF01403.19 EMC90053.1 - 4.8e-65 220.0 3.2 4.8e-65 220.0 3.2 2.3 1 1 1 2 2 2 1 Sema domain TIG PF01833.24 EMC90053.1 - 7.1e-37 125.4 12.2 5.2e-12 45.7 2.0 5.8 5 0 0 5 5 5 4 IPT/TIG domain PSI PF01437.25 EMC90053.1 - 3.4e-15 56.3 50.1 9.5e-10 38.9 16.5 3.7 3 0 0 3 3 3 3 Plexin repeat TIG_plexin PF17960.1 EMC90053.1 - 4.5e-15 55.4 0.1 4.5e-15 55.4 0.1 3.3 3 0 0 3 3 3 1 TIG domain RasGAP PF00616.19 EMC90053.1 - 0.00017 21.4 0.1 0.0029 17.4 0.0 2.8 2 1 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase ubiquitin PF00240.23 EMC90053.1 - 0.04 13.7 0.3 0.9 9.3 0.0 3.1 3 0 0 3 3 3 0 Ubiquitin family Amino_oxidase PF01593.24 EMC90054.1 - 5e-75 253.5 0.0 6e-75 253.3 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EMC90054.1 - 4e-15 55.8 0.1 9.8e-15 54.5 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EMC90054.1 - 1.8e-06 28.4 2.0 4.4e-06 27.2 0.3 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMC90054.1 - 2.2e-06 27.1 0.0 1.2e-05 24.7 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMC90054.1 - 3.3e-06 26.9 0.0 1.2e-05 25.1 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EMC90054.1 - 1.1e-05 24.8 0.0 2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 EMC90054.1 - 3.7e-05 23.0 0.2 6.9e-05 22.1 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.21 EMC90054.1 - 7.6e-05 22.1 0.1 0.00025 20.4 0.1 1.7 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 EMC90054.1 - 0.00011 21.6 0.2 0.00023 20.6 0.2 1.5 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EMC90054.1 - 0.00033 19.5 0.2 0.00068 18.4 0.2 1.5 1 0 0 1 1 1 1 HI0933-like protein FAD_oxidored PF12831.7 EMC90054.1 - 0.00068 19.1 0.0 0.00097 18.6 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EMC90054.1 - 0.0011 18.1 0.1 0.063 12.3 0.1 2.4 3 0 0 3 3 3 1 Lycopene cyclase protein FMO-like PF00743.19 EMC90054.1 - 0.0077 14.7 0.0 0.013 14.0 0.0 1.2 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Trp_halogenase PF04820.14 EMC90054.1 - 0.0086 15.0 0.8 0.017 14.0 0.4 1.6 2 0 0 2 2 2 1 Tryptophan halogenase NAD_binding_9 PF13454.6 EMC90054.1 - 0.019 15.0 0.2 0.049 13.6 0.0 1.8 2 0 0 2 2 1 0 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 EMC90054.1 - 0.023 13.9 0.0 0.046 13.0 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 EMC90054.1 - 0.057 12.2 0.0 0.088 11.6 0.0 1.2 1 0 0 1 1 1 0 MCRA family GIDA PF01134.22 EMC90054.1 - 0.081 12.0 0.1 0.28 10.2 0.1 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A TrkA_N PF02254.18 EMC90054.1 - 0.12 12.7 0.0 0.29 11.4 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.18 EMC90054.1 - 0.15 12.0 0.1 0.25 11.2 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.12 EMC90054.1 - 0.16 11.5 0.1 0.28 10.7 0.1 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain ApbA PF02558.16 EMC90054.1 - 0.43 10.2 2.2 0.61 9.7 0.4 2.1 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA PRY PF13765.6 EMC90056.1 - 4.6e-20 71.0 0.5 5.4e-19 67.6 0.1 2.2 2 0 0 2 2 2 1 SPRY-associated domain SPRY PF00622.28 EMC90056.1 - 2.3e-15 56.8 0.3 3e-15 56.4 0.3 1.1 1 0 0 1 1 1 1 SPRY domain Neuralized PF07177.12 EMC90056.1 - 0.011 15.8 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 0 Neuralized PRY PF13765.6 EMC90058.1 - 2.5e-18 65.4 0.4 6.3e-18 64.1 0.4 1.7 1 0 0 1 1 1 1 SPRY-associated domain V-set PF07686.17 EMC90058.1 - 1.8e-13 50.6 0.0 3.6e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC90058.1 - 2.6e-10 40.8 0.0 2.8e-07 31.0 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC90058.1 - 2.8e-08 33.7 0.0 1.3e-06 28.4 0.0 2.5 2 1 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.25 EMC90058.1 - 4.6e-05 23.5 0.0 0.0003 20.9 0.0 2.4 2 1 0 2 2 2 1 Immunoglobulin domain SPRY PF00622.28 EMC90058.1 - 5.9e-05 23.2 0.0 0.00012 22.2 0.0 1.5 1 0 0 1 1 1 1 SPRY domain Ig_2 PF13895.6 EMC90058.1 - 0.047 14.0 0.0 1.8 9.0 0.0 2.9 2 1 0 2 2 2 0 Immunoglobulin domain C2-set_2 PF08205.12 EMC90058.1 - 0.11 12.5 0.0 0.33 11.0 0.0 1.7 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain PRY PF13765.6 EMC90059.1 - 1.3e-17 63.1 0.2 4e-17 61.6 0.1 1.9 2 0 0 2 2 2 1 SPRY-associated domain SPRY PF00622.28 EMC90059.1 - 3.1e-13 49.9 0.0 5e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.24 EMC90059.1 - 4e-09 36.5 0.4 4e-09 36.5 0.4 2.8 3 1 0 3 3 2 1 B-box zinc finger zf-C3HC4_3 PF13920.6 EMC90059.1 - 1.6e-05 24.7 3.9 1.6e-05 24.7 3.9 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC90059.1 - 4e-05 23.4 3.4 4e-05 23.4 3.4 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC90059.1 - 0.00015 21.6 5.1 0.00036 20.3 5.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC90059.1 - 0.00042 20.2 5.3 0.00042 20.2 5.3 1.9 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EMC90059.1 - 0.0022 18.3 4.7 0.0022 18.3 4.7 2.0 2 0 0 2 2 1 1 Ring finger domain Fer2 PF00111.27 EMC90059.1 - 0.051 13.5 5.5 0.35 10.9 2.0 2.6 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Fer2_3 PF13085.6 EMC90059.1 - 0.25 11.3 2.3 0.82 9.7 2.3 1.8 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Rhabdo_M1 PF03342.13 EMC90059.1 - 0.26 10.6 2.8 0.21 10.9 0.6 1.8 1 1 0 1 1 1 0 Rhabdovirus M1 matrix protein (M1 polymerase-associated protein) zf-RING_UBOX PF13445.6 EMC90059.1 - 0.44 10.6 9.8 0.27 11.3 6.8 2.3 2 0 0 2 2 2 0 RING-type zinc-finger Exonuc_VII_L PF02601.15 EMC90059.1 - 0.97 8.9 7.3 1.3 8.6 7.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit zf-RING_4 PF14570.6 EMC90059.1 - 1.7 8.5 8.8 0.34 10.7 1.5 2.6 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Fib_alpha PF08702.10 EMC90059.1 - 1.9 8.7 9.2 2.9 8.1 9.2 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Prok-RING_4 PF14447.6 EMC90059.1 - 3.3 7.6 9.6 0.9 9.4 5.7 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Spc7 PF08317.11 EMC90059.1 - 5.7 5.7 16.9 8.1 5.2 16.9 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein FapA PF03961.13 EMC90059.1 - 8.7 4.8 7.6 13 4.3 7.6 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A zf-H2C2_2 PF13465.6 EMC90061.1 - 5.7e-30 102.4 21.5 4e-08 33.3 0.2 4.2 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2 PF00096.26 EMC90061.1 - 3.1e-17 62.0 35.3 1.1e-05 25.6 0.2 5.7 5 1 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC90061.1 - 2e-14 53.0 25.3 0.0006 20.4 0.7 5.1 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC90061.1 - 7.2e-08 32.2 21.5 6.7e-05 22.8 0.9 5.3 5 0 0 5 5 4 1 C2H2-type zinc finger CpXC PF14353.6 EMC90061.1 - 2.1e-06 27.8 11.9 0.11 12.6 0.1 4.3 1 1 4 5 5 4 3 CpXC protein DZR PF12773.7 EMC90061.1 - 2.6e-06 27.4 10.9 0.0036 17.3 12.3 3.0 1 1 1 2 2 2 2 Double zinc ribbon zf-met PF12874.7 EMC90061.1 - 5.8e-06 26.5 4.2 0.11 13.0 0.0 4.5 4 1 0 4 4 4 1 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 EMC90061.1 - 2e-05 24.8 6.2 0.006 16.9 0.2 2.8 1 1 2 3 3 3 2 C2H2-type zinc ribbon zf_UBZ PF18439.1 EMC90061.1 - 2.4e-05 23.8 13.0 0.25 11.0 0.1 4.6 5 0 0 5 5 4 3 Ubiquitin-Binding Zinc Finger DUF3268 PF11672.8 EMC90061.1 - 3.8e-05 24.0 8.8 0.013 15.8 0.1 2.7 1 1 3 4 4 4 3 zinc-finger-containing domain zf-Di19 PF05605.12 EMC90061.1 - 4.1e-05 23.8 13.1 0.89 9.9 0.1 3.8 1 1 3 4 4 4 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.5 EMC90061.1 - 5.3e-05 22.9 16.9 0.11 12.3 0.1 5.2 5 0 0 5 5 5 2 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 EMC90061.1 - 8.2e-05 22.6 15.5 0.0058 16.7 2.3 3.5 1 1 3 4 4 4 3 Zinc ribbon domain HypA PF01155.19 EMC90061.1 - 0.00014 21.8 2.5 0.025 14.6 0.1 2.4 1 1 2 3 3 3 3 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_9 PF14369.6 EMC90061.1 - 0.00018 21.7 9.3 0.98 9.7 0.1 4.1 4 0 0 4 4 4 1 zinc-ribbon TF_Zn_Ribbon PF08271.12 EMC90061.1 - 0.0014 18.1 0.2 0.0014 18.1 0.2 3.4 3 1 0 3 3 2 2 TFIIB zinc-binding zinc_ribbon_15 PF17032.5 EMC90061.1 - 0.0019 18.9 7.7 0.011 16.5 0.5 2.2 1 1 1 2 2 2 1 zinc-ribbon family zf-C2H2_jaz PF12171.8 EMC90061.1 - 0.0022 18.2 0.9 25 5.3 0.0 4.5 4 1 0 4 4 4 0 Zinc-finger double-stranded RNA-binding Zn_ribbon_recom PF13408.6 EMC90061.1 - 0.0049 17.4 12.4 1 9.9 0.1 3.8 2 1 2 4 4 4 1 Recombinase zinc beta ribbon domain Terminase_GpA PF05876.12 EMC90061.1 - 0.0065 15.1 6.8 0.0089 14.6 0.5 2.0 1 1 1 2 2 2 1 Phage terminase large subunit (GpA) zf-AN1 PF01428.16 EMC90061.1 - 0.013 15.6 12.4 2.6 8.3 0.1 4.3 4 0 0 4 4 4 0 AN1-like Zinc finger zf-3CxxC PF13695.6 EMC90061.1 - 0.015 15.8 4.5 1.9 9.0 1.6 3.2 1 1 1 2 2 2 0 Zinc-binding domain Ribosomal_L37ae PF01780.19 EMC90061.1 - 0.021 14.9 10.4 6.9 6.8 3.1 4.0 1 1 2 3 3 3 0 Ribosomal L37ae protein family FYDLN_acid PF09538.10 EMC90061.1 - 0.022 15.4 8.5 1.9 9.2 0.1 3.4 1 1 3 4 4 3 0 Protein of unknown function (FYDLN_acid) Zn_ribbon_SprT PF17283.2 EMC90061.1 - 0.029 14.3 22.0 0.041 13.8 1.7 4.0 3 2 0 3 3 2 0 SprT-like zinc ribbon domain TFIIS_C PF01096.18 EMC90061.1 - 0.029 14.2 12.4 10 6.1 0.0 4.2 4 0 0 4 4 4 0 Transcription factor S-II (TFIIS) LIM PF00412.22 EMC90061.1 - 0.034 14.4 1.0 0.034 14.4 1.0 3.3 3 1 0 3 3 2 0 LIM domain zf-LYAR PF08790.11 EMC90061.1 - 0.039 13.8 15.5 0.33 10.9 0.2 4.2 5 0 0 5 5 3 0 LYAR-type C2HC zinc finger DNA_ligase_ZBD PF03119.16 EMC90061.1 - 0.05 13.6 12.5 11 6.1 0.0 4.1 3 1 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain zinc_ribbon_4 PF13717.6 EMC90061.1 - 0.051 13.5 11.3 8 6.5 0.0 4.2 4 0 0 4 4 4 0 zinc-ribbon domain YacG PF03884.14 EMC90061.1 - 0.071 12.9 9.4 9.6 6.0 0.0 4.0 4 0 0 4 4 4 0 DNA gyrase inhibitor YacG Zn_Tnp_IS1595 PF12760.7 EMC90061.1 - 0.071 13.1 19.1 0.49 10.4 3.5 3.5 1 1 2 3 3 3 0 Transposase zinc-ribbon domain Ogr_Delta PF04606.12 EMC90061.1 - 0.077 13.0 16.4 0.21 11.6 0.3 4.0 3 1 0 3 3 3 0 Ogr/Delta-like zinc finger ARS2 PF04959.13 EMC90061.1 - 0.097 13.0 0.0 1.1 9.6 0.1 2.0 2 0 0 2 2 2 0 Arsenite-resistance protein 2 zf-trcl PF13451.6 EMC90061.1 - 0.1 12.5 12.4 1.7 8.6 0.0 3.9 3 1 0 3 3 3 0 Probable zinc-ribbon domain DUF1610 PF07754.11 EMC90061.1 - 0.15 12.1 0.7 0.15 12.1 0.7 4.7 5 0 0 5 5 4 0 Domain of unknown function (DUF1610) Cytochrom_CIII PF02085.16 EMC90061.1 - 0.15 12.4 6.0 0.48 10.8 6.0 1.8 1 1 0 1 1 1 0 Class III cytochrome C family ADK_lid PF05191.14 EMC90061.1 - 0.16 12.0 11.8 2.6 8.1 4.2 3.6 2 1 0 2 2 2 0 Adenylate kinase, active site lid zinc-ribbons_6 PF07191.12 EMC90061.1 - 0.17 11.9 10.8 98 3.0 10.8 3.3 1 1 0 1 1 1 0 zinc-ribbons zf-ribbon_3 PF13248.6 EMC90061.1 - 0.2 11.1 20.4 2.1 7.9 0.1 4.6 5 0 0 5 5 4 0 zinc-ribbon domain C1_4 PF07975.12 EMC90061.1 - 0.21 11.9 11.2 1.4 9.2 0.6 3.7 1 1 3 4 4 4 0 TFIIH C1-like domain zf-C2HC_2 PF13913.6 EMC90061.1 - 0.22 11.5 0.7 0.22 11.5 0.7 4.1 4 0 0 4 4 4 0 zinc-finger of a C2HC-type zf-HIT PF04438.16 EMC90061.1 - 0.26 11.2 18.5 3 7.8 0.2 4.3 4 0 0 4 4 4 0 HIT zinc finger zf-ISL3 PF14690.6 EMC90061.1 - 0.41 11.3 17.3 1.6 9.4 0.6 4.3 4 0 0 4 4 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 DNA_RNApol_7kD PF03604.13 EMC90061.1 - 0.49 10.1 11.1 10 5.9 0.1 4.2 4 0 0 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit GcpE PF04551.14 EMC90061.1 - 0.51 9.4 4.6 0.64 9.0 0.1 2.6 1 1 2 3 3 3 0 GcpE protein zf-C4_Topoisom PF01396.19 EMC90061.1 - 0.54 10.1 18.9 2.1 8.2 0.2 4.6 3 1 1 4 4 4 0 Topoisomerase DNA binding C4 zinc finger zf-Mss51 PF13824.6 EMC90061.1 - 0.55 10.4 19.1 0.73 10.0 0.4 3.9 1 1 3 4 4 4 0 Zinc-finger of mitochondrial splicing suppressor 51 XPA_N PF01286.18 EMC90061.1 - 0.57 10.3 12.6 4.6 7.4 0.1 4.1 4 0 0 4 4 4 0 XPA protein N-terminal zinc_ribbon_2 PF13240.6 EMC90061.1 - 0.62 9.9 24.9 1 9.2 0.1 5.2 5 1 0 5 5 5 0 zinc-ribbon domain HalOD2 PF18547.1 EMC90061.1 - 0.65 9.9 12.0 0.84 9.6 1.0 3.8 4 1 0 4 4 3 0 Halobacterial output domain 2 Zn_Tnp_IS91 PF14319.6 EMC90061.1 - 0.67 10.0 12.4 10 6.2 2.1 3.8 1 1 2 3 3 3 0 Transposase zinc-binding domain zf-IS66 PF13005.7 EMC90061.1 - 0.84 10.1 14.5 14 6.2 0.1 4.3 4 0 0 4 4 3 0 zinc-finger binding domain of transposase IS66 zf_C2H2_10 PF18414.1 EMC90061.1 - 0.97 9.0 0.1 0.97 9.0 0.1 4.5 4 0 0 4 4 4 0 C2H2 type zinc-finger DUF3797 PF12677.7 EMC90061.1 - 1.1 9.2 12.7 6.9 6.6 0.4 4.0 2 1 2 4 4 4 0 Domain of unknown function (DUF3797) zf-DNA_Pol PF08996.10 EMC90061.1 - 1.2 8.9 6.9 0.2 11.4 0.5 2.0 1 1 1 2 2 2 0 DNA Polymerase alpha zinc finger YhfH PF14149.6 EMC90061.1 - 1.3 9.1 16.6 7.5 6.6 0.0 4.3 5 0 0 5 5 3 0 YhfH-like protein Gmx_para_CXXCG PF09535.10 EMC90061.1 - 1.6 8.0 7.0 2.8 7.1 0.1 3.0 1 1 2 3 3 3 0 Protein of unknown function (Gmx_para_CXXCG) A2L_zn_ribbon PF08792.10 EMC90061.1 - 1.7 8.5 12.8 14 5.5 0.1 4.1 4 0 0 4 4 4 0 A2L zinc ribbon domain PhnA_Zn_Ribbon PF08274.12 EMC90061.1 - 1.8 8.6 13.0 27 4.8 0.1 4.2 4 0 0 4 4 4 0 PhnA Zinc-Ribbon GFA PF04828.14 EMC90061.1 - 2.5 8.5 13.0 8.1 6.9 0.2 3.6 1 1 3 4 4 4 0 Glutathione-dependent formaldehyde-activating enzyme zf-3CxxC_2 PF17180.4 EMC90061.1 - 2.6 8.9 14.1 16 6.3 0.1 4.1 2 2 1 3 3 3 0 Zinc-binding domain TerY_C PF15616.6 EMC90061.1 - 3.2 7.9 8.8 0.29 11.2 0.3 2.5 1 1 2 3 3 3 0 TerY-C metal binding domain zf-C2H2_9 PF16293.5 EMC90061.1 - 5.1 7.0 5.4 12 5.9 0.0 3.2 4 0 0 4 4 3 0 C2H2 type zinc-finger (1 copy) zf-RING_7 PF02591.15 EMC90061.1 - 6.3 7.1 13.5 4.7 7.5 0.1 3.9 4 0 0 4 4 4 0 C4-type zinc ribbon domain OrfB_Zn_ribbon PF07282.11 EMC90061.1 - 7.6 6.5 15.1 5.8 6.9 2.5 3.7 1 1 2 3 3 3 0 Putative transposase DNA-binding domain zf-C2HE PF16278.5 EMC90061.1 - 8.8 6.9 14.7 28 5.2 0.1 3.9 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger Cript PF10235.9 EMC90061.1 - 8.9 7.0 12.1 13 6.4 0.1 3.9 2 2 2 4 4 3 0 Microtubule-associated protein CRIPT DUF4171 PF13775.6 EMC90062.1 - 4.3e-46 156.7 27.3 4.3e-46 156.7 27.3 4.9 5 1 1 6 6 6 1 Domain of unknown function (DUF4171) HMG_box PF00505.19 EMC90062.1 - 3.4e-15 56.2 2.4 3.4e-15 56.2 2.4 3.3 4 0 0 4 4 4 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC90062.1 - 6.3e-09 36.3 2.0 6.3e-09 36.3 2.0 2.7 2 1 0 2 2 2 1 HMG-box domain VHS PF00790.19 EMC90063.1 - 1.2e-45 154.8 0.0 2.3e-45 153.9 0.0 1.5 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 EMC90063.1 - 6.9e-25 87.2 3.3 1.5e-24 86.1 3.3 1.5 1 0 0 1 1 1 1 GAT domain Baculo_PEP_C PF04513.12 EMC90063.1 - 0.19 11.7 2.0 1.5 8.9 0.5 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Heme_oxygenase PF01126.20 EMC90065.1 - 9.2e-80 267.3 2.2 1.2e-79 266.9 2.2 1.1 1 0 0 1 1 1 1 Heme oxygenase DNA_Packaging_2 PF11123.8 EMC90065.1 - 0.13 12.4 0.0 0.37 11.0 0.0 1.7 1 0 0 1 1 1 0 DNA packaging protein MCM PF00493.23 EMC90066.1 - 2.3e-100 334.3 0.0 3.9e-100 333.5 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EMC90066.1 - 2.8e-40 137.1 0.7 5.7e-40 136.1 0.7 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EMC90066.1 - 6.5e-26 90.6 0.8 2e-25 89.0 0.8 1.9 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EMC90066.1 - 1.9e-10 41.2 0.8 5.1e-10 39.9 0.8 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EMC90066.1 - 9.7e-07 28.4 0.0 0.00042 19.8 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EMC90066.1 - 0.00039 20.4 0.0 0.0013 18.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EMC90066.1 - 0.0093 15.8 0.0 0.03 14.2 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EMC90066.1 - 0.028 14.1 0.0 0.23 11.2 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain TrmB PF01978.19 EMC90066.1 - 0.084 12.8 1.1 0.51 10.3 0.4 2.3 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB zf-C3HC4_3 PF13920.6 EMC90067.1 - 2.6e-13 49.6 9.6 2.6e-13 49.6 9.6 2.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SWIB PF02201.18 EMC90067.1 - 1.6e-10 40.7 0.1 4.4e-10 39.3 0.0 1.8 2 0 0 2 2 2 1 SWIB/MDM2 domain zf-RanBP PF00641.18 EMC90067.1 - 6.6e-09 34.9 1.9 6.6e-09 34.9 1.9 2.6 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others zf-RING_2 PF13639.6 EMC90067.1 - 0.016 15.6 9.5 0.016 15.6 9.5 2.2 2 0 0 2 2 2 0 Ring finger domain Viral_DNA_bp PF00747.17 EMC90067.1 - 0.04 11.1 1.1 2.8 5.0 0.0 2.0 2 0 0 2 2 2 0 ssDNA binding protein zf-FPG_IleRS PF06827.14 EMC90067.1 - 0.095 12.6 0.1 0.095 12.6 0.1 3.8 4 0 0 4 4 4 0 Zinc finger found in FPG and IleRS DZR PF12773.7 EMC90067.1 - 0.1 12.6 14.7 0.59 10.2 1.9 3.3 3 0 0 3 3 3 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 EMC90067.1 - 0.57 10.0 9.3 0.16 11.7 2.4 3.0 2 0 0 2 2 2 0 zinc-ribbon domain zinc-ribbons_6 PF07191.12 EMC90067.1 - 5.5 7.0 12.2 1 9.4 4.8 2.8 2 0 0 2 2 2 0 zinc-ribbons Peptidase_M14 PF00246.24 EMC90068.1 - 1.3e-67 228.6 0.1 1.8e-67 228.2 0.1 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.6 EMC90068.1 - 2.3e-11 43.8 0.0 6.1e-11 42.4 0.0 1.7 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 EMC90068.1 - 7.1e-08 32.3 0.0 1.3e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 CarboxypepD_reg-like domain AstE_AspA PF04952.14 EMC90068.1 - 1e-07 31.3 0.1 2e-07 30.4 0.1 1.4 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family Dioxygenase_C PF00775.21 EMC90068.1 - 0.019 14.4 0.0 0.038 13.4 0.0 1.5 1 0 0 1 1 1 0 Dioxygenase CooC_C PF15976.5 EMC90068.1 - 0.18 11.9 0.0 1.3 9.1 0.0 2.1 2 0 0 2 2 2 0 CS1-pili formation C-terminal TPR_2 PF07719.17 EMC90069.1 - 4.5e-08 32.6 2.3 0.00021 21.2 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EMC90069.1 - 0.0079 15.9 8.2 0.57 9.9 1.5 3.1 3 0 0 3 3 3 2 TPR repeat PaREP1 PF05942.11 EMC90069.1 - 0.013 15.4 0.3 0.037 13.9 0.0 1.8 2 0 0 2 2 2 0 Archaeal PaREP1/PaREP8 family TPR_16 PF13432.6 EMC90069.1 - 0.058 14.1 4.6 0.77 10.5 0.2 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EMC90069.1 - 0.16 11.8 9.5 0.47 10.4 0.1 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 EMC90069.1 - 0.19 11.6 3.3 1.1 9.2 0.5 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat EF-hand_1 PF00036.32 EMC90070.1 - 1.4e-32 108.8 12.6 7.1e-10 37.7 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EMC90070.1 - 1.7e-26 89.8 5.6 2.3e-09 36.5 0.1 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 EMC90070.1 - 3.7e-25 88.2 9.3 3e-16 59.6 1.3 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EMC90070.1 - 1.7e-23 82.2 9.2 3e-13 49.4 0.9 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EMC90070.1 - 1.4e-22 78.1 9.6 6.7e-09 34.9 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 EMC90070.1 - 1.1e-09 38.5 0.3 0.00072 19.8 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EMC90070.1 - 0.0001 22.6 0.1 0.022 15.1 0.0 2.3 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 EMC90070.1 - 0.0011 19.1 0.8 0.064 13.5 0.7 2.9 2 1 1 3 3 3 2 Dockerin type I domain EF-hand_4 PF12763.7 EMC90070.1 - 0.0014 18.5 2.7 0.044 13.7 0.3 2.7 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 EMC90070.1 - 0.0026 17.7 0.0 0.46 10.4 0.0 2.5 2 1 0 2 2 2 1 Caleosin related protein Prefoldin_3 PF13758.6 EMC90070.1 - 0.004 17.2 0.0 0.66 10.1 0.1 2.3 1 1 1 2 2 2 1 Prefoldin subunit DUF3349 PF11829.8 EMC90070.1 - 0.0071 17.1 0.0 0.51 11.2 0.0 2.2 1 1 0 2 2 2 1 Protein of unknown function (DUF3349) OST-HTH PF12872.7 EMC90070.1 - 0.0075 16.1 0.0 0.16 11.8 0.0 2.4 2 0 0 2 2 2 1 OST-HTH/LOTUS domain DIMCO_N PF16844.5 EMC90070.1 - 0.0094 16.3 0.1 0.11 12.8 0.0 2.2 2 0 0 2 2 2 1 Dinitrogenase iron-molybdenum cofactor, N-terminal TerB PF05099.13 EMC90070.1 - 0.016 15.2 0.2 1.3 9.0 0.0 2.5 2 1 0 2 2 2 0 Tellurite resistance protein TerB Acetyltransf_11 PF13720.6 EMC90070.1 - 0.06 13.8 0.1 14 6.2 0.0 2.6 2 1 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 EFhand_Ca_insen PF08726.10 EMC90070.1 - 0.093 12.8 2.2 1.1 9.4 0.4 2.9 2 2 0 2 2 2 0 Ca2+ insensitive EF hand VbhA PF18495.1 EMC90070.1 - 0.14 12.1 0.0 14 5.7 0.1 3.1 3 0 0 3 3 3 0 Antitoxin VbhA DUF5580 PF17743.1 EMC90070.1 - 0.15 10.5 0.0 0.63 8.5 0.0 1.7 1 1 1 2 2 2 0 Family of unknown function (DUF5580) Mito_carr PF00153.27 EMC90071.1 - 2.3e-13 49.9 0.0 1.8e-11 43.8 0.0 2.2 2 0 0 2 2 2 2 Mitochondrial carrier protein CDP-OH_P_tran_2 PF08009.11 EMC90071.1 - 1.7 8.6 0.0 1.7 8.6 0.0 2.8 3 0 0 3 3 3 0 CDP-alcohol phosphatidyltransferase 2 WW PF00397.26 EMC90072.1 - 1.8e-19 69.5 19.6 3.1e-10 39.9 4.1 2.4 2 0 0 2 2 2 2 WW domain ASD2 PF08687.11 EMC90072.1 - 0.015 14.9 0.6 0.015 14.9 0.6 2.2 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Glyco_hyd_101C PF17451.2 EMC90072.1 - 0.029 14.6 3.8 0.55 10.5 0.8 2.7 2 0 0 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain RhoGEF PF00621.20 EMC90073.1 - 8.9e-44 149.9 0.1 1e-43 149.7 0.1 1.0 1 0 0 1 1 1 1 RhoGEF domain Prenyltrans PF00432.21 EMC90074.1 - 2.5e-30 103.9 12.7 2.5e-11 43.1 0.6 3.6 3 0 0 3 3 3 3 Prenyltransferase and squalene oxidase repeat Churchill PF06573.11 EMC90074.1 - 1.5e-07 31.7 1.7 1.5e-07 31.7 1.7 2.0 2 0 0 2 2 2 1 Churchill protein HLH PF00010.26 EMC90075.1 - 1.9e-18 66.1 0.7 3.6e-18 65.3 0.7 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain JAKMIP_CC3 PF16034.5 EMC90075.1 - 0.0077 16.2 3.1 0.0087 16.0 3.1 1.3 1 1 0 1 1 1 1 JAKMIP CC3 domain bZIP_2 PF07716.15 EMC90075.1 - 0.0079 16.3 3.1 0.0079 16.3 3.1 2.1 2 2 0 2 2 2 1 Basic region leucine zipper SLX9 PF15341.6 EMC90075.1 - 0.013 15.8 4.4 0.015 15.7 4.4 1.0 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 Filament PF00038.21 EMC90075.1 - 0.014 15.0 5.8 0.016 14.8 5.8 1.0 1 0 0 1 1 1 0 Intermediate filament protein SlyX PF04102.12 EMC90075.1 - 0.017 15.7 5.4 0.036 14.7 3.6 2.1 1 1 2 3 3 3 0 SlyX ATG16 PF08614.11 EMC90075.1 - 0.02 15.1 7.1 0.026 14.7 7.1 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) CREPT PF16566.5 EMC90075.1 - 0.024 14.8 3.6 0.028 14.6 3.6 1.1 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour DUF5595 PF18077.1 EMC90075.1 - 0.037 14.1 1.6 0.051 13.6 0.9 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) HALZ PF02183.18 EMC90075.1 - 0.13 12.5 4.3 2 8.7 1.4 2.4 3 0 0 3 3 3 0 Homeobox associated leucine zipper PMBR PF09373.10 EMC90075.1 - 0.15 12.3 0.1 0.24 11.6 0.1 1.4 1 0 0 1 1 1 0 Pseudomurein-binding repeat Csm1_N PF18504.1 EMC90075.1 - 0.23 11.8 4.1 1.6 9.2 3.7 2.0 1 1 1 2 2 2 0 Csm1 N-terminal domain DivIC PF04977.15 EMC90075.1 - 0.45 10.3 5.3 0.44 10.4 3.8 1.8 1 1 1 2 2 2 0 Septum formation initiator UNC-93 PF05978.16 EMC90076.1 - 1.5e-05 24.7 4.0 1.5e-05 24.7 4.0 2.7 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 Aldedh PF00171.22 EMC90077.1 - 2.7e-86 289.9 0.0 3.5e-86 289.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Fer4 PF00037.27 EMC90078.1 - 8.9e-15 53.8 17.4 1.4e-08 34.2 4.5 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 EMC90078.1 - 5e-13 49.4 10.9 8.3e-13 48.7 10.9 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 EMC90078.1 - 1.6e-11 45.0 6.7 3.1e-05 24.8 0.2 2.4 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 EMC90078.1 - 2e-10 40.6 3.9 6.4e-05 23.0 0.6 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 EMC90078.1 - 9.1e-10 38.8 0.3 0.00032 21.1 0.1 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 EMC90078.1 - 2.5e-09 37.1 20.6 1.2e-06 28.5 12.5 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 EMC90078.1 - 5.4e-09 36.1 10.4 9.7e-09 35.3 10.4 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 EMC90078.1 - 1.2e-07 31.5 17.7 0.00017 21.5 5.3 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 EMC90078.1 - 2e-07 30.7 12.6 0.0022 18.0 2.0 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 EMC90078.1 - 1.2e-05 25.4 11.6 0.00066 20.0 2.2 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 EMC90078.1 - 0.00066 20.2 14.6 0.015 15.8 13.1 2.5 2 1 2 4 4 3 3 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.10 EMC90078.1 - 0.0057 16.9 5.8 0.46 10.7 0.3 2.3 1 1 1 2 2 2 2 c-SKI Smad4 binding domain Fer4_13 PF13370.6 EMC90078.1 - 0.012 16.2 14.4 0.57 10.8 2.7 2.5 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_18 PF13746.6 EMC90078.1 - 0.013 15.7 9.1 0.36 11.0 1.7 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 EMC90078.1 - 0.051 14.5 17.4 0.28 12.2 4.1 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain ETF_QO PF05187.13 EMC90078.1 - 0.18 12.0 5.5 1.4 9.1 0.5 2.4 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S EPF PF17181.4 EMC90078.1 - 0.27 11.3 5.0 0.2 11.6 0.8 2.2 2 0 0 2 2 2 0 Epidermal patterning factor proteins Fer4_22 PF17179.4 EMC90078.1 - 0.46 11.4 12.2 2 9.3 1.8 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain Prenyltrans PF00432.21 EMC90079.1 - 1.1 9.0 11.1 0.92 9.3 0.8 3.3 2 1 1 3 3 3 0 Prenyltransferase and squalene oxidase repeat V_ATPase_I PF01496.19 EMC90080.1 - 2.4e-251 836.2 0.1 2.7e-251 836.0 0.1 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF2321 PF10083.9 EMC90080.1 - 0.097 12.3 0.8 0.16 11.6 0.2 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) MRVI1 PF05781.12 EMC90080.1 - 0.25 10.0 0.5 0.4 9.3 0.5 1.2 1 0 0 1 1 1 0 MRVI1 protein T-box PF00907.22 EMC90081.1 - 2.5e-69 233.3 0.1 2e-68 230.3 0.1 1.9 1 1 0 1 1 1 1 T-box 7tm_4 PF13853.6 EMC90082.1 - 1.3e-46 159.6 14.2 1.8e-46 159.1 14.2 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC90082.1 - 1e-25 90.6 13.8 1.5e-25 90.0 13.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC90082.1 - 0.0024 17.3 14.1 0.0068 15.8 13.8 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC90083.1 - 3.5e-56 191.0 16.7 4.4e-56 190.7 16.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC90083.1 - 5.4e-22 78.4 17.1 7.7e-22 77.9 17.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 EMC90084.1 - 1e-56 192.7 15.3 1.2e-56 192.5 15.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC90084.1 - 1.1e-22 80.7 16.6 1.7e-22 80.0 16.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC90084.1 - 0.00069 19.1 14.8 0.0017 17.8 14.8 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx VGCC_beta4Aa_N PF12052.8 EMC90084.1 - 0.033 14.3 0.9 0.064 13.4 0.9 1.4 1 0 0 1 1 1 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal SP_C-Propep PF08999.10 EMC90084.1 - 0.089 12.6 5.8 0.48 10.2 0.0 2.8 3 0 0 3 3 3 0 Surfactant protein C, N terminal propeptide 7tm_4 PF13853.6 EMC90085.1 - 3.5e-45 154.9 18.9 4.6e-25 88.9 7.4 2.1 2 0 0 2 2 2 2 Olfactory receptor 7tm_1 PF00001.21 EMC90085.1 - 1.3e-37 129.5 11.5 8e-20 71.3 3.8 2.1 2 0 0 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC90085.1 - 1.3e-11 44.3 16.2 5.3e-06 26.0 5.9 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx SLC3A2_N PF16028.5 EMC90085.1 - 0.0041 16.6 0.4 0.39 10.3 0.1 2.5 2 0 0 2 2 2 1 Solute carrier family 3 member 2 N-terminus Sterol_MT_C PF08498.10 EMC90085.1 - 0.046 14.0 2.1 4.2 7.7 0.1 2.6 2 0 0 2 2 2 0 Sterol methyltransferase C-terminal TFIID_NTD2 PF04494.15 EMC90085.1 - 0.53 10.5 2.1 21 5.4 0.2 2.6 3 0 0 3 3 3 0 WD40 associated region in TFIID subunit, NTD2 domain XPG_N PF00752.17 EMC90086.1 - 5.1e-37 126.4 0.0 1.7e-36 124.7 0.0 1.9 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.18 EMC90086.1 - 1.2e-30 105.7 0.3 3.1e-30 104.4 0.0 1.9 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.20 EMC90086.1 - 1.3e-07 32.1 0.1 7.7e-07 29.6 0.0 2.2 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 EMC90086.1 - 0.025 15.2 0.0 0.062 13.9 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain Ost5 PF05251.12 EMC90087.1 - 1.4e-28 98.9 6.9 1.5e-28 98.8 6.9 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit 5 Phage_holin_3_3 PF16083.5 EMC90087.1 - 0.0017 18.4 1.0 0.0024 18.0 1.0 1.4 1 1 0 1 1 1 1 LydA holin phage, holin superfamily III Sdh5 PF03937.16 EMC90088.1 - 1.3e-25 89.1 0.5 1.8e-25 88.7 0.5 1.2 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase Transmemb_17 PF09799.9 EMC90089.1 - 8.2e-19 68.2 4.7 1.1e-18 67.8 4.7 1.2 1 0 0 1 1 1 1 Predicted membrane protein Lactamase_B_4 PF13691.6 EMC90089.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 tRNase Z endonuclease TMEM138 PF14935.6 EMC90090.1 - 1.4e-31 109.6 9.6 1.4e-31 109.6 9.6 1.4 2 0 0 2 2 2 1 Transmembrane protein 138 Cytochrom_B561 PF03188.16 EMC90091.1 - 7.7e-46 155.6 7.2 1.4e-45 154.8 7.2 1.4 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 Ni_hydr_CYTB PF01292.20 EMC90091.1 - 0.45 10.1 22.7 17 5.0 20.7 3.0 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 DUF4079 PF13301.6 EMC90091.1 - 0.8 9.9 15.3 0.079 13.1 7.2 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) DUF2427 PF10348.9 EMC90091.1 - 1.7 8.5 10.0 15 5.5 6.8 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF2427) Holin_9 PF16936.5 EMC90091.1 - 1.7 8.8 11.9 0.64 10.2 6.4 2.9 2 1 0 2 2 2 0 Putative holin Dak1 PF02733.17 EMC90092.1 - 1e-49 169.1 0.0 1.5e-49 168.6 0.0 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 EMC90092.1 - 2.4e-30 105.7 0.0 3.6e-30 105.1 0.0 1.3 1 0 0 1 1 1 1 DAK2 domain MMS1_N PF10433.9 EMC90093.1 - 8.7e-118 394.0 0.0 2.1e-117 392.7 0.0 1.6 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EMC90093.1 - 6.8e-81 272.1 0.1 5.9e-80 269.0 0.1 2.4 2 0 0 2 2 2 1 CPSF A subunit region VWC PF00093.18 EMC90094.1 - 7.9e-22 77.3 90.1 5.9e-09 36.1 10.4 6.5 6 1 0 6 6 6 5 von Willebrand factor type C domain Asp PF00026.23 EMC90095.1 - 7.6e-109 363.9 0.2 8.5e-109 363.8 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EMC90095.1 - 6.8e-17 62.3 4.5 9.3e-15 55.3 1.5 2.9 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EMC90095.1 - 1.9e-05 25.2 0.0 0.083 13.5 0.0 2.7 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EMC90095.1 - 0.00033 21.2 0.0 0.83 10.2 0.0 2.6 2 1 0 2 2 2 2 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 EMC90095.1 - 0.00048 19.9 0.0 0.29 10.9 0.0 2.5 2 1 1 3 3 3 2 Xylanase inhibitor C-terminal Methyltransf_32 PF13679.6 EMC90096.1 - 1.3e-31 109.7 10.8 8e-30 103.9 10.8 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMC90096.1 - 0.00022 21.9 0.0 0.00077 20.1 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC90096.1 - 0.0014 18.5 0.0 0.0031 17.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMC90096.1 - 0.0014 18.5 0.0 0.006 16.4 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMC90096.1 - 0.0036 17.9 0.0 0.023 15.3 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain MTS PF05175.14 EMC90096.1 - 0.022 14.3 0.0 0.052 13.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_18 PF12847.7 EMC90096.1 - 0.022 14.7 0.0 0.044 13.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 EMC90096.1 - 0.065 12.8 0.0 0.22 11.1 0.0 1.8 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW PCMT PF01135.19 EMC90096.1 - 0.079 12.7 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) NapE PF06796.11 EMC90096.1 - 0.14 11.7 0.1 0.56 9.8 0.0 2.1 2 0 0 2 2 2 0 Periplasmic nitrate reductase protein NapE GCOM2 PF15328.6 EMC90096.1 - 0.17 12.3 4.8 0.29 11.5 4.8 1.4 1 0 0 1 1 1 0 Putative GRINL1B complex locus protein 2 Collagen PF01391.18 EMC90097.1 - 5.8e-13 48.4 82.1 1.1e-08 34.6 36.6 3.3 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) NUDIX PF00293.28 EMC90098.1 - 6.2e-19 68.4 0.2 1.2e-17 64.2 0.0 2.6 3 0 0 3 3 3 1 NUDIX domain Ank_2 PF12796.7 EMC90098.1 - 1.4e-11 44.8 0.7 4.2e-11 43.3 0.6 1.8 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC90098.1 - 6e-09 36.0 0.1 1.3e-08 34.9 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) zf-NADH-PPase PF09297.11 EMC90098.1 - 4e-08 32.8 0.4 7.8e-08 31.8 0.4 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain NUDIX-like PF09296.11 EMC90098.1 - 6.2e-08 33.2 0.0 1.3e-07 32.2 0.0 1.6 1 0 0 1 1 1 1 NADH pyrophosphatase-like rudimentary NUDIX domain Ank_4 PF13637.6 EMC90098.1 - 3.5e-07 30.6 2.3 1.7e-05 25.3 0.4 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC90098.1 - 5.2e-06 26.4 0.3 0.00046 20.4 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 EMC90098.1 - 6.3e-06 26.4 1.3 0.0004 20.7 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeat DNA_ligase_ZBD PF03119.16 EMC90098.1 - 0.22 11.6 0.9 0.61 10.2 0.9 1.8 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain PH PF00169.29 EMC90099.1 - 4.9e-30 104.1 0.9 5.7e-17 62.2 0.3 2.6 2 0 0 2 2 2 2 PH domain PDZ PF00595.24 EMC90099.1 - 2.3e-14 53.5 0.1 4.1e-14 52.7 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC90099.1 - 2.5e-12 46.5 0.2 4.4e-12 45.7 0.2 1.4 1 0 0 1 1 1 1 PDZ domain PH_11 PF15413.6 EMC90099.1 - 6.4e-10 39.4 11.4 0.00011 22.5 6.7 4.4 2 2 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 EMC90099.1 - 1e-07 32.1 0.5 2.4e-06 27.7 0.4 2.7 2 1 0 2 2 2 1 Pleckstrin homology domain PDZ_2 PF13180.6 EMC90099.1 - 2.1e-06 27.9 0.0 4.7e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PH_9 PF15410.6 EMC90099.1 - 0.005 17.2 1.1 1.3 9.4 0.1 3.3 2 2 1 3 3 3 1 Pleckstrin homology domain PH_3 PF14593.6 EMC90099.1 - 0.0055 16.8 0.4 0.064 13.4 0.0 2.3 2 0 0 2 2 2 1 PH domain PH_15 PF17339.2 EMC90099.1 - 0.075 12.9 0.1 0.36 10.7 0.0 2.0 2 0 0 2 2 2 0 PH domain UNC119_bdg PF15435.6 EMC90100.1 - 3e-107 356.6 0.7 3.4e-107 356.4 0.7 1.0 1 0 0 1 1 1 1 UNC119-binding protein C5orf30 homologue His_Phos_2 PF00328.22 EMC90101.1 - 2.2e-137 458.5 1.2 2.9e-137 458.1 1.2 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 EMC90101.1 - 8.5e-43 144.4 0.4 2.2e-42 143.1 0.4 1.8 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 EMC90101.1 - 0.0018 17.9 0.0 0.0036 16.9 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Integrase_H2C2 PF17921.1 EMC90102.1 - 3.4e-16 59.1 1.2 7.5e-16 58.0 1.2 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 EMC90102.1 - 1.3e-05 25.3 1.0 3.4e-05 24.0 1.0 1.8 1 0 0 1 1 1 1 H2C2 zinc finger rve PF00665.26 EMC90102.1 - 4.1e-05 23.8 0.0 0.00025 21.2 0.0 2.3 1 1 1 2 2 2 1 Integrase core domain AbiJ_NTD4 PF18863.1 EMC90102.1 - 0.005 17.3 0.8 0.18 12.2 0.0 2.5 2 1 0 2 2 2 1 AbiJ N-terminal domain 4 Pox_A3L PF05288.11 EMC90102.1 - 0.09 12.8 0.9 0.24 11.4 0.1 2.1 2 0 0 2 2 2 0 Poxvirus A3L Protein bMG6 PF17962.1 EMC90102.1 - 0.86 9.8 3.9 0.58 10.3 0.4 2.2 2 0 0 2 2 2 0 Bacterial macroglobulin domain 6 Cu2_monoox_C PF03712.15 EMC90103.1 - 3.5e-44 150.1 0.3 3.5e-44 150.1 0.3 1.7 2 0 0 2 2 2 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain Cu2_monooxygen PF01082.20 EMC90103.1 - 3.3e-25 88.8 0.0 6.6e-25 87.8 0.0 1.5 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain NHL PF01436.21 EMC90103.1 - 8.8e-19 66.5 6.8 2.6e-05 24.0 0.1 6.1 6 0 0 6 6 6 4 NHL repeat DUF2207 PF09972.9 EMC90103.1 - 0.065 12.0 0.0 0.1 11.4 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) LMBR1 PF04791.16 EMC90103.1 - 0.075 11.9 0.9 0.089 11.7 0.1 1.4 2 0 0 2 2 2 0 LMBR1-like membrane protein DUF5128 PF17170.4 EMC90103.1 - 0.08 12.1 0.0 0.2 10.8 0.0 1.6 2 0 0 2 2 2 0 6-bladed beta-propeller OATP PF03137.20 EMC90104.1 - 1.5e-33 115.9 1.9 2.2e-33 115.4 1.9 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 EMC90104.1 - 0.013 14.5 4.0 0.019 13.9 4.0 1.4 1 1 0 1 1 1 0 Major Facilitator Superfamily Claudin_3 PF06653.11 EMC90104.1 - 0.6 10.0 6.5 1.4 8.8 6.5 1.5 1 1 0 1 1 1 0 Tight junction protein, Claudin-like TLV_coat PF00429.19 EMC90105.1 - 3e-11 42.7 1.4 3.4e-11 42.5 1.4 1.0 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) GP41 PF00517.17 EMC90105.1 - 0.0063 16.4 0.0 0.039 13.8 0.0 1.9 2 0 0 2 2 2 1 Retroviral envelope protein RVT_1 PF00078.27 EMC90106.1 - 0.099 12.1 0.1 0.16 11.5 0.1 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Glyco_transf_29 PF00777.18 EMC90107.1 - 1.6e-76 257.2 0.0 2.1e-76 256.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) RVT_1 PF00078.27 EMC90108.1 - 0.001 18.6 0.0 0.001 18.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) UL42 PF17638.2 EMC90108.1 - 0.18 11.8 0.0 2.3 8.2 0.0 2.1 2 0 0 2 2 2 0 HCMV UL42 PurA PF04845.13 EMC90110.1 - 9.5e-107 355.3 0.0 1.1e-106 355.1 0.0 1.0 1 0 0 1 1 1 1 PurA ssDNA and RNA-binding protein DUF3276 PF11680.8 EMC90110.1 - 0.033 14.3 5.6 1.7 8.8 0.1 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3276) Metallophos PF00149.28 EMC90112.1 - 3.2e-35 122.5 0.5 5.4e-35 121.8 0.5 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EMC90112.1 - 0.0043 17.5 0.4 0.01 16.3 0.4 1.6 1 1 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Glyco_hydro_65N PF03636.15 EMC90112.1 - 0.021 14.5 0.0 0.032 13.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain DUF5378 PF17349.2 EMC90112.1 - 0.088 12.1 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5378) Pyr_redox_2 PF07992.14 EMC90113.1 - 4.5e-36 124.6 0.0 6.4e-36 124.1 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMC90113.1 - 4.6e-19 68.8 0.1 8e-19 68.0 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EMC90113.1 - 4.3e-14 52.7 0.1 8.5e-14 51.7 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_3 PF13738.6 EMC90113.1 - 3.3e-08 33.2 0.0 4.4e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMC90113.1 - 0.00023 20.4 0.0 0.00054 19.2 0.0 1.5 1 1 1 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Cytadhesin_P30 PF07271.11 EMC90113.1 - 0.081 12.5 1.3 0.7 9.4 1.0 2.1 2 0 0 2 2 2 0 Cytadhesin P30/P32 Sox_N PF12444.8 EMC90114.1 - 0.0033 18.5 1.0 30 5.8 0.0 5.5 5 1 1 6 6 6 1 Sox developmental protein N terminal PRY PF13765.6 EMC90115.1 - 1.3e-20 72.7 0.1 2.4e-20 71.9 0.1 1.4 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.28 EMC90115.1 - 2e-14 53.8 0.0 2.3e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 SPRY domain MBT PF02820.18 EMC90116.1 - 2.5e-49 165.5 0.5 8.1e-24 83.8 0.1 2.8 3 0 0 3 3 3 2 mbt repeat SLED PF12140.8 EMC90116.1 - 5e-39 133.3 0.1 9.1e-39 132.4 0.1 1.4 1 0 0 1 1 1 1 SLED domain SAM_1 PF00536.30 EMC90116.1 - 1.7e-08 34.8 0.0 3.3e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 EMC90116.1 - 2.3e-05 24.3 0.0 5.9e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_2 PF07647.17 EMC90116.1 - 8.9e-05 22.5 0.0 0.0002 21.4 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 EMC90116.1 - 0.0029 17.8 2.0 0.0077 16.5 0.1 2.5 2 1 1 3 3 3 1 Ste50p, sterile alpha motif Ac76 PF05814.11 EMC90117.1 - 0.0023 17.9 0.2 0.0031 17.5 0.2 1.2 1 0 0 1 1 1 1 Orf76 (Ac76) FAM209 PF15206.6 EMC90117.1 - 0.01 15.6 0.1 0.011 15.6 0.1 1.0 1 0 0 1 1 1 0 FAM209 family DUF4834 PF16118.5 EMC90117.1 - 0.014 16.3 0.1 0.02 15.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) MscL PF01741.18 EMC90117.1 - 0.022 15.0 0.1 0.025 14.9 0.1 1.1 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL Connexin PF00029.19 EMC90117.1 - 0.03 14.1 0.1 0.039 13.7 0.1 1.1 1 0 0 1 1 1 0 Connexin ETRAMP PF09716.10 EMC90117.1 - 0.036 14.1 0.5 0.045 13.8 0.5 1.1 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) 7TM_GPCR_Srd PF10317.9 EMC90117.1 - 0.04 13.1 0.1 0.044 13.0 0.1 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srd MFS_1 PF07690.16 EMC90117.1 - 0.072 12.0 0.0 0.077 11.9 0.0 1.0 1 0 0 1 1 1 0 Major Facilitator Superfamily TMEM192 PF14802.6 EMC90118.1 - 1.1e-85 286.5 3.2 1.3e-85 286.3 3.2 1.0 1 0 0 1 1 1 1 TMEM192 family Fig1 PF12351.8 EMC90118.1 - 0.094 12.6 0.3 0.17 11.8 0.3 1.4 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 Kelch_1 PF01344.25 EMC90119.1 - 1.4e-88 290.3 26.1 1.2e-16 60.0 1.7 6.6 7 0 0 7 7 7 6 Kelch motif Kelch_6 PF13964.6 EMC90119.1 - 1.3e-40 136.3 4.1 9.4e-08 32.1 0.0 6.3 4 2 2 6 6 6 6 Kelch motif Kelch_2 PF07646.15 EMC90119.1 - 1.4e-31 107.3 10.2 1.8e-05 24.5 0.1 6.3 6 0 0 6 6 6 5 Kelch motif BTB PF00651.31 EMC90119.1 - 2.8e-31 108.0 0.1 6.2e-31 106.9 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 EMC90119.1 - 1.8e-30 105.1 2.1 6.9e-30 103.2 2.1 2.1 1 1 0 1 1 1 1 BTB And C-terminal Kelch Kelch_3 PF13415.6 EMC90119.1 - 2.5e-30 104.2 15.7 8.1e-06 26.0 0.2 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_4 PF13418.6 EMC90119.1 - 7.3e-23 80.3 6.2 0.00059 19.8 0.1 6.4 4 1 2 6 6 6 5 Galactose oxidase, central domain PQQ_3 PF13570.6 EMC90119.1 - 0.00051 20.4 11.5 0.46 11.0 0.0 5.1 5 0 0 5 5 5 2 PQQ-like domain Kelch_5 PF13854.6 EMC90119.1 - 0.00059 19.8 17.3 0.69 10.0 0.1 5.1 5 0 0 5 5 5 4 Kelch motif Glu_cyclase_2 PF05096.12 EMC90119.1 - 0.15 11.5 0.1 7.4 5.9 0.0 2.7 1 1 2 3 3 3 0 Glutamine cyclotransferase FA_hydroxylase PF04116.13 EMC90120.1 - 7.6e-27 94.3 15.8 7.6e-27 94.3 15.8 1.7 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily CLAMP PF14769.6 EMC90120.1 - 0.019 15.4 0.3 0.058 13.8 0.1 1.9 2 1 0 2 2 2 0 Flagellar C1a complex subunit C1a-32 DUF4886 PF16227.5 EMC90120.1 - 0.067 12.4 0.1 0.12 11.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4886) Peptidase_M14 PF00246.24 EMC90121.1 - 5.3e-62 210.2 0.0 6.4e-62 210.0 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.6 EMC90121.1 - 1.7e-15 57.1 0.0 2.5e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 EMC90121.1 - 5.8e-07 29.4 0.0 1e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 CarboxypepD_reg-like domain AstE_AspA PF04952.14 EMC90121.1 - 0.014 14.4 0.0 0.04 13.0 0.0 1.6 1 1 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family CUB PF00431.20 EMC90122.1 - 2.7e-188 613.5 6.3 1.5e-40 137.9 0.2 5.3 5 0 0 5 5 5 5 CUB domain Astacin PF01400.24 EMC90122.1 - 3.9e-73 245.1 0.1 9.8e-73 243.9 0.0 1.7 2 0 0 2 2 2 1 Astacin (Peptidase family M12A) FXa_inhibition PF14670.6 EMC90122.1 - 1.3e-19 70.2 28.4 1.2e-09 38.3 9.8 3.0 2 0 0 2 2 2 2 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 EMC90122.1 - 2.8e-12 46.6 30.7 4.4e-07 30.0 8.5 2.9 2 0 0 2 2 2 2 Calcium-binding EGF domain cEGF PF12662.7 EMC90122.1 - 1.2e-09 37.9 7.9 4.1e-05 23.4 2.3 3.2 2 0 0 2 2 2 2 Complement Clr-like EGF-like EGF PF00008.27 EMC90122.1 - 3.5e-07 30.4 21.3 0.00065 20.0 6.7 2.9 2 0 0 2 2 2 2 EGF-like domain CUB_2 PF02408.20 EMC90122.1 - 2.3e-05 24.1 4.2 0.85 9.4 0.0 4.4 4 0 0 4 4 4 3 CUB-like domain EGF_3 PF12947.7 EMC90122.1 - 3.4e-05 24.0 24.8 0.00042 20.4 4.8 3.6 2 1 1 3 3 3 2 EGF domain hEGF PF12661.7 EMC90122.1 - 0.00028 21.4 19.9 0.068 13.8 5.5 3.1 2 0 0 2 2 2 2 Human growth factor-like EGF Peptidase_M10 PF00413.24 EMC90122.1 - 0.0023 17.8 0.1 0.72 9.7 0.0 2.6 2 0 0 2 2 2 1 Matrixin Reprolysin_4 PF13583.6 EMC90122.1 - 0.019 14.6 0.0 0.033 13.8 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like AWS PF17907.1 EMC90122.1 - 3.4 7.8 10.2 9 6.4 1.2 3.0 2 0 0 2 2 2 0 AWS domain SPARC_Ca_bdg PF10591.9 EMC90123.1 - 6.5e-34 116.6 1.8 1.1e-33 115.9 1.8 1.4 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Thyroglobulin_1 PF00086.18 EMC90123.1 - 5.3e-18 64.5 6.8 5.3e-18 64.5 6.8 3.2 4 0 0 4 4 4 1 Thyroglobulin type-1 repeat Kazal_2 PF07648.15 EMC90123.1 - 4.8e-13 49.0 16.7 2e-12 47.1 10.6 3.1 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EMC90123.1 - 5.8e-06 26.2 7.6 5.8e-06 26.2 7.6 3.7 3 1 0 3 3 3 1 Kazal-type serine protease inhibitor domain TFIIA PF03153.13 EMC90123.1 - 8.3 6.3 9.6 10 6.0 9.6 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit C1-set PF07654.15 EMC90124.1 - 6.2e-11 42.5 0.2 1.1e-10 41.7 0.2 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain V-set PF07686.17 EMC90124.1 - 8.9e-11 41.9 0.1 1.9e-10 40.9 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC90124.1 - 1.7e-05 25.3 0.3 0.21 12.2 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 EMC90124.1 - 0.034 14.3 1.3 0.45 10.7 0.0 2.5 2 1 0 2 2 2 0 Immunoglobulin domain I-set PF07679.16 EMC90124.1 - 0.048 13.7 0.5 0.34 11.0 0.0 2.2 2 0 0 2 2 2 0 Immunoglobulin I-set domain Cation_ATPase_N PF00690.26 EMC90126.1 - 4.6e-13 48.6 0.0 8.5e-13 47.8 0.0 1.4 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Oxidored_q3 PF00499.20 EMC90126.1 - 0.013 15.3 0.1 0.016 15.0 0.1 1.1 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Tetraspanin PF00335.20 EMC90126.1 - 0.044 13.5 0.6 0.051 13.3 0.6 1.1 1 0 0 1 1 1 0 Tetraspanin family DUF4149 PF13664.6 EMC90126.1 - 0.074 13.4 0.0 0.091 13.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4149) PRY PF13765.6 EMC90127.1 - 2.6e-20 71.8 0.5 4e-20 71.2 0.5 1.3 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.28 EMC90127.1 - 3.2e-13 49.8 0.2 4.4e-13 49.4 0.2 1.1 1 0 0 1 1 1 1 SPRY domain LRR_8 PF13855.6 EMC90128.1 - 1.7e-30 104.6 27.1 3.7e-15 55.4 0.2 3.7 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EMC90128.1 - 5.3e-18 64.8 16.2 3.1e-05 24.2 0.0 4.6 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EMC90128.1 - 4e-08 32.7 7.7 2.6 8.3 0.0 6.2 6 0 0 6 6 6 4 Leucine Rich repeat LRR_9 PF14580.6 EMC90128.1 - 7.3e-08 32.1 2.6 0.0021 17.6 0.5 2.6 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 EMC90128.1 - 6.4e-07 29.0 10.3 4.3 8.3 0.0 5.9 4 1 0 4 4 4 3 Leucine Rich Repeat LRR_5 PF13306.6 EMC90128.1 - 0.0009 19.2 0.0 0.0087 16.0 0.0 2.0 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) Kelch_1 PF01344.25 EMC90129.1 - 2.2e-37 126.4 15.8 2e-11 43.3 0.4 6.1 6 1 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 EMC90129.1 - 4.3e-24 83.9 8.1 4.7e-09 36.2 0.1 5.7 3 2 2 5 5 5 4 Kelch motif BACK PF07707.15 EMC90129.1 - 1.3e-20 73.4 0.0 2.1e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_3 PF13415.6 EMC90129.1 - 2.5e-14 53.1 7.1 0.0021 18.3 0.1 5.3 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_2 PF07646.15 EMC90129.1 - 2.6e-14 52.5 6.3 0.036 14.0 0.1 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 EMC90129.1 - 1.6e-13 50.4 7.9 0.0002 21.3 0.1 5.7 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC90129.1 - 3e-10 39.8 15.3 0.00083 19.3 0.4 5.4 5 0 0 5 5 5 4 Kelch motif BTB PF00651.31 EMC90129.1 - 0.048 13.9 0.0 0.18 12.0 0.0 1.9 1 1 1 2 2 2 0 BTB/POZ domain Tim17 PF02466.19 EMC90130.1 - 4.6e-08 33.4 0.5 8.4e-08 32.6 0.5 1.4 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family PRR22 PF15776.5 EMC90131.1 - 0.032 13.6 0.8 0.032 13.6 0.8 2.2 1 1 0 2 2 2 0 Proline-rich protein family 22 Ran_BP1 PF00638.18 EMC90132.1 - 7.9e-14 52.0 0.0 1.5e-13 51.0 0.0 1.4 1 0 0 1 1 1 1 RanBP1 domain I-set PF07679.16 EMC90135.1 - 9.8e-70 230.7 0.9 7.7e-17 61.2 0.0 6.6 7 0 0 7 7 7 5 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC90135.1 - 2.2e-63 210.8 10.3 1.3e-12 48.1 0.0 6.8 8 0 0 8 8 8 5 Immunoglobulin domain fn3 PF00041.21 EMC90135.1 - 5.2e-45 151.7 20.4 3.7e-15 56.1 2.2 4.4 4 0 0 4 4 4 4 Fibronectin type III domain Ig_2 PF13895.6 EMC90135.1 - 4.2e-44 148.8 0.3 2.5e-11 43.7 0.1 5.5 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 EMC90135.1 - 4.8e-44 148.5 2.0 9e-09 35.4 0.1 7.0 6 1 0 6 6 6 5 Immunoglobulin domain V-set PF07686.17 EMC90135.1 - 1.2e-27 96.2 11.7 0.0032 17.6 0.0 10.5 7 4 1 8 8 8 6 Immunoglobulin V-set domain Ig_5 PF16681.5 EMC90135.1 - 2.7e-11 43.7 0.0 0.083 13.3 0.0 6.1 6 0 0 6 6 6 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 EMC90135.1 - 8.9e-10 38.0 0.0 0.67 9.6 0.0 5.4 5 0 0 5 5 5 3 Immunoglobulin domain Tissue_fac PF01108.17 EMC90135.1 - 2.2e-07 30.7 4.6 3.4e-05 23.7 0.2 3.1 4 0 0 4 4 4 2 Tissue factor Izumo-Ig PF16706.5 EMC90135.1 - 2.1e-06 27.7 0.2 1.8 8.7 0.0 5.4 5 0 0 5 5 5 1 Izumo-like Immunoglobulin domain C2-set_2 PF08205.12 EMC90135.1 - 0.00046 20.2 8.3 2.2 8.4 0.0 5.3 5 0 0 5 5 5 2 CD80-like C2-set immunoglobulin domain Interfer-bind PF09294.10 EMC90135.1 - 0.0022 18.3 0.1 8 6.8 0.0 3.4 3 0 0 3 3 3 1 Interferon-alpha/beta receptor, fibronectin type III Pur_ac_phosph_N PF16656.5 EMC90135.1 - 0.0047 17.5 12.4 0.1 13.2 0.9 3.8 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Egh16-like PF11327.8 EMC90135.1 - 0.024 15.1 0.2 0.12 12.8 0.0 2.3 2 0 0 2 2 2 0 Egh16-like virulence factor Big_4 PF07532.11 EMC90135.1 - 0.052 13.3 5.5 1.6 8.5 0.2 3.9 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 4) zf-C3HC4_2 PF13923.6 EMC90136.1 - 1.1e-09 38.0 7.7 1.1e-09 38.0 7.7 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC90136.1 - 5.4e-08 32.6 6.2 2.1e-07 30.7 6.2 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PDZ PF00595.24 EMC90136.1 - 1.5e-07 31.7 0.2 2.7e-07 30.8 0.2 1.4 1 0 0 1 1 1 1 PDZ domain zf-RING_UBOX PF13445.6 EMC90136.1 - 2.4e-07 30.7 6.4 8.1e-07 29.0 6.4 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EMC90136.1 - 1.3e-06 28.2 5.3 3.8e-06 26.7 5.3 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Sina PF03145.16 EMC90136.1 - 2.7e-06 27.5 2.6 4.4e-06 26.8 2.6 1.3 1 0 0 1 1 1 1 Seven in absentia protein family Prok-RING_4 PF14447.6 EMC90136.1 - 3.8e-06 26.7 7.2 9.8e-06 25.3 7.2 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EMC90136.1 - 4.1e-06 26.7 6.3 1.5e-05 24.8 6.3 2.1 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EMC90136.1 - 4.4e-06 26.9 7.6 4.4e-06 26.9 7.6 2.6 3 1 0 3 3 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 EMC90136.1 - 1.2e-05 25.3 7.5 3.4e-05 23.9 7.5 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-TRAF PF02176.18 EMC90136.1 - 0.00088 19.9 11.2 0.0021 18.7 4.6 2.9 1 1 1 2 2 2 1 TRAF-type zinc finger zf-rbx1 PF12678.7 EMC90136.1 - 0.0052 17.0 5.0 0.0052 17.0 5.0 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger domain U-box PF04564.15 EMC90136.1 - 0.0064 16.6 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 U-box domain PDZ_2 PF13180.6 EMC90136.1 - 0.015 15.6 0.0 0.026 14.8 0.0 1.4 1 0 0 1 1 1 0 PDZ domain PDZ_6 PF17820.1 EMC90136.1 - 0.069 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 PDZ domain zf-RING_6 PF14835.6 EMC90136.1 - 0.12 12.3 4.2 0.16 11.9 2.6 2.1 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 EMC90136.1 - 0.19 11.9 7.0 0.59 10.3 7.0 1.9 1 0 0 1 1 1 0 zinc RING finger of MSL2 PPP4R2 PF09184.11 EMC90137.1 - 9.9e-73 245.2 42.7 1.2e-67 228.5 42.7 2.6 1 1 0 1 1 1 1 PPP4R2 Glyco_transf_8 PF01501.20 EMC90138.1 - 3e-12 46.6 0.0 5.4e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 EMC90138.1 - 0.00048 19.6 0.6 0.00062 19.3 0.6 1.2 1 0 0 1 1 1 1 Glucosyltransferase 24 YAF2_RYBP PF17219.3 EMC90139.1 - 1.4e-20 72.5 1.2 3.2e-20 71.4 1.2 1.7 1 0 0 1 1 1 1 Yaf2/RYBP C-terminal binding motif zf-RanBP PF00641.18 EMC90139.1 - 1.8e-08 33.5 2.4 3.6e-08 32.6 2.4 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others C1_2 PF03107.16 EMC90139.1 - 0.11 12.9 1.0 0.21 12.0 1.0 1.4 1 0 0 1 1 1 0 C1 domain DUF4808 PF16066.5 EMC90139.1 - 7.5 7.1 7.6 2.3 8.8 0.1 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4808) Prokineticin PF06607.11 EMC90140.1 - 9.1e-40 134.9 9.5 1e-39 134.8 9.5 1.0 1 0 0 1 1 1 1 Prokineticin MIT_LIKE_ACTX PF17556.2 EMC90140.1 - 0.00071 20.1 7.7 0.00093 19.8 7.7 1.2 1 0 0 1 1 1 1 MIT-like atracotoxin family 7tm_1 PF00001.21 EMC90141.1 - 7e-31 107.5 10.5 8.4e-31 107.2 10.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) UPF0114 PF03350.16 EMC90141.1 - 1.8 8.8 6.9 0.88 9.8 3.7 2.0 1 1 0 2 2 2 0 Uncharacterized protein family, UPF0114 7tm_4 PF13853.6 EMC90142.1 - 9.9e-09 35.3 0.3 1.2e-08 35.1 0.3 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC90142.1 - 3.9e-08 33.0 0.1 4.9e-08 32.6 0.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V-set PF07686.17 EMC90143.1 - 3.4e-13 49.7 0.2 4e-13 49.5 0.2 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 EMC90143.1 - 4.4e-05 23.6 0.2 8.1e-05 22.7 0.2 1.4 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC90143.1 - 7.2e-05 22.8 0.2 0.00018 21.5 0.2 1.6 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC90143.1 - 0.0001 22.8 0.1 0.00023 21.7 0.1 1.5 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC90143.1 - 0.00031 21.0 1.2 0.011 16.0 1.2 2.1 1 1 0 1 1 1 1 Immunoglobulin domain Ig_4 PF16680.5 EMC90143.1 - 0.0077 16.5 0.8 0.21 11.9 0.0 2.1 1 1 1 2 2 2 1 T-cell surface glycoprotein CD3 delta chain V-set PF07686.17 EMC90144.1 - 1.4e-14 54.2 0.0 1.5e-14 54.1 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 EMC90144.1 - 4.9e-07 29.8 0.2 4.3e-06 26.8 0.2 2.0 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC90144.1 - 2.9e-06 27.8 0.0 9e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC90144.1 - 1.8e-05 25.0 0.4 0.00014 22.1 0.4 2.0 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC90144.1 - 5e-05 23.3 0.0 0.00012 22.0 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_5 PF16681.5 EMC90144.1 - 0.025 15.0 0.2 0.57 10.6 0.2 2.1 1 1 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 EMC90144.1 - 0.031 14.5 0.1 1.4 9.2 0.0 2.2 1 1 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain fragilysinNterm PF16376.5 EMC90144.1 - 0.061 13.1 0.0 0.062 13.1 0.0 1.2 1 0 0 1 1 1 0 N-terminal domain of fragilysin Apelin PF15360.6 EMC90145.1 - 0.34 11.5 0.2 0.34 11.5 0.2 2.4 2 0 0 2 2 2 0 APJ endogenous ligand zf-CHCC PF10276.9 EMC90146.1 - 8.7 6.5 12.9 6.6 6.9 0.6 4.1 4 1 0 4 4 4 0 Zinc-finger domain Choline_transpo PF04515.12 EMC90147.1 - 2.8e-96 322.6 33.8 2.8e-96 322.6 33.8 2.1 2 0 0 2 2 2 2 Plasma-membrane choline transporter Renin_r PF07850.14 EMC90147.1 - 0.25 11.9 0.1 0.25 11.9 0.1 3.3 2 1 1 3 3 3 0 Renin receptor-like protein C2 PF00168.30 EMC90149.1 - 5.1e-76 251.6 8.3 5e-17 62.1 0.0 9.2 8 1 0 8 8 8 6 C2 domain FerB PF08150.12 EMC90149.1 - 2e-31 108.4 0.5 7.4e-31 106.6 0.1 2.3 2 0 0 2 2 2 1 FerB (NUC096) domain Ferlin_C PF16165.5 EMC90149.1 - 6.8e-31 107.3 3.6 1.1e-27 96.8 0.2 5.0 3 2 2 5 5 5 2 Ferlin C-terminus FerI PF08151.12 EMC90149.1 - 0.00026 21.0 0.2 0.00078 19.5 0.2 1.9 1 0 0 1 1 1 1 FerI (NUC094) domain HSP70 PF00012.20 EMC90149.1 - 0.28 9.3 15.2 0.51 8.4 15.2 1.3 1 0 0 1 1 1 0 Hsp70 protein UPF0640 PF15114.6 EMC90149.1 - 0.3 10.9 0.9 7.7 6.4 0.2 2.6 2 0 0 2 2 2 0 Uncharacterised protein family UPF0640 Myotub-related PF06602.14 EMC90152.1 - 8.1e-136 452.6 0.0 1.1e-135 452.2 0.0 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain FYVE PF01363.21 EMC90152.1 - 2.6e-16 59.5 13.4 8.6e-16 57.8 13.4 2.0 1 0 0 1 1 1 1 FYVE zinc finger Y_phosphatase PF00102.27 EMC90152.1 - 0.0076 15.8 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EMC90152.1 - 0.019 14.8 0.0 0.045 13.6 0.0 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMC90152.1 - 0.025 14.6 0.0 0.043 13.8 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Peptidase_C14 PF00656.22 EMC90153.1 - 8.8e-46 156.9 0.0 1.1e-45 156.5 0.0 1.1 1 0 0 1 1 1 1 Caspase domain CARD PF00619.21 EMC90153.1 - 1.3e-15 57.2 0.8 2.7e-15 56.1 0.3 1.8 2 0 0 2 2 2 1 Caspase recruitment domain Abhydrolase_1 PF00561.20 EMC90154.1 - 1.3e-16 61.0 0.0 1.9e-12 47.4 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMC90154.1 - 9.4e-15 55.8 0.0 1.1e-14 55.6 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMC90154.1 - 8.5e-08 31.8 0.1 3.2e-07 29.9 0.1 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EMC90154.1 - 8e-06 25.7 0.0 1.1e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Esterase PF00756.20 EMC90154.1 - 0.00037 20.2 0.0 0.00049 19.8 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Ndr PF03096.14 EMC90154.1 - 0.0038 16.0 0.0 0.0067 15.2 0.0 1.4 2 0 0 2 2 2 1 Ndr family Chlorophyllase2 PF12740.7 EMC90154.1 - 0.0045 15.9 0.0 0.0063 15.5 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme DUF2048 PF09752.9 EMC90154.1 - 0.0051 15.9 0.0 0.018 14.1 0.0 1.8 1 1 0 1 1 1 1 Abhydrolase domain containing 18 Chlorophyllase PF07224.11 EMC90154.1 - 0.04 12.9 0.0 0.057 12.4 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Lipase_3 PF01764.25 EMC90154.1 - 0.05 13.5 0.0 0.071 13.0 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF1057 PF06342.12 EMC90154.1 - 0.14 11.1 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) PAF-AH_p_II PF03403.13 EMC90154.1 - 0.16 10.4 0.0 0.22 10.0 0.0 1.1 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Ser_hydrolase PF06821.13 EMC90154.1 - 0.19 11.5 0.0 11 5.9 0.0 2.1 1 1 0 2 2 2 0 Serine hydrolase PMP22_Claudin PF00822.20 EMC90155.1 - 1.5e-32 112.7 10.9 1.8e-32 112.5 10.9 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC90155.1 - 1.3e-08 34.8 13.8 8.1e-08 32.2 13.8 1.9 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF4064 PF13273.6 EMC90155.1 - 0.065 13.5 7.3 1 9.7 7.8 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) ABC2_membrane_3 PF12698.7 EMC90155.1 - 0.27 10.3 3.8 0.38 9.8 3.8 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF3671 PF12420.8 EMC90155.1 - 0.84 9.7 5.8 0.11 12.6 2.0 1.5 2 0 0 2 2 2 0 Protein of unknown function Lin-8 PF03353.15 EMC90156.1 - 0.55 9.7 4.1 0.61 9.6 4.1 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist PMP22_Claudin PF00822.20 EMC90157.1 - 5e-34 117.6 10.9 5.9e-34 117.3 10.9 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC90157.1 - 1.5e-10 41.1 12.8 1.2e-09 38.2 12.7 2.0 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF872 PF05915.12 EMC90157.1 - 0.0057 16.8 0.6 0.0057 16.8 0.6 2.2 3 0 0 3 3 3 1 Eukaryotic protein of unknown function (DUF872) TMEM37 PF15108.6 EMC90157.1 - 0.016 15.1 6.4 0.026 14.4 6.4 1.4 1 0 0 1 1 1 0 Voltage-dependent calcium channel gamma-like subunit protein family DUF3185 PF11381.8 EMC90157.1 - 5.2 7.1 21.7 2.1 8.4 6.5 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF3185) PMP22_Claudin PF00822.20 EMC90158.1 - 6.2e-31 107.5 10.3 7.3e-31 107.3 10.3 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC90158.1 - 6.7e-07 29.3 13.3 5.9e-06 26.2 13.3 1.9 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction YtpI PF14007.6 EMC90158.1 - 0.053 13.7 1.7 0.25 11.5 1.7 2.1 1 1 0 1 1 1 0 YtpI-like protein PIRT PF15099.6 EMC90158.1 - 0.1 12.2 0.1 0.21 11.2 0.1 1.5 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family Amastin PF07344.11 EMC90158.1 - 1.3 8.9 9.3 2.1 8.2 8.4 1.9 1 1 0 1 1 1 0 Amastin surface glycoprotein DUF1129 PF06570.11 EMC90158.1 - 1.7 8.1 6.3 5.9 6.3 4.3 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) DiS_P_DiS PF06750.13 EMC90159.1 - 1.6 8.9 5.6 3.7 7.7 5.6 1.5 1 0 0 1 1 1 0 Bacterial Peptidase A24 N-terminal domain PT PF04886.12 EMC90160.1 - 4e-11 42.3 0.8 0.029 13.9 0.8 4.4 1 1 0 1 1 1 1 PT repeat Pkinase_Tyr PF07714.17 EMC90161.1 - 8.9e-47 159.5 0.0 1.4e-46 158.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMC90161.1 - 8.1e-45 153.2 0.0 1.1e-44 152.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain LIM PF00412.22 EMC90161.1 - 1.1e-19 70.4 18.4 8e-14 51.6 7.2 2.5 2 0 0 2 2 2 2 LIM domain PDZ PF00595.24 EMC90161.1 - 1.3e-09 38.3 0.0 2.8e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Kdo PF06293.14 EMC90161.1 - 1.2e-06 28.0 0.2 2e-06 27.3 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PDZ_6 PF17820.1 EMC90161.1 - 0.00059 19.6 0.1 0.0039 17.0 0.0 2.2 2 0 0 2 2 2 1 PDZ domain APH PF01636.23 EMC90161.1 - 0.0019 18.2 0.1 0.004 17.1 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EMC90161.1 - 0.02 13.8 0.0 0.029 13.3 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 EMC90161.1 - 0.024 14.2 0.0 0.047 13.3 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 EMC90161.1 - 0.038 12.8 0.0 0.056 12.2 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase PknG_TPR PF16918.5 EMC90161.1 - 0.077 11.7 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein kinase G tetratricopeptide repeat Kinase-like PF14531.6 EMC90161.1 - 0.15 11.4 0.0 16 4.7 0.0 2.1 2 0 0 2 2 2 0 Kinase-like PDZ_2 PF13180.6 EMC90161.1 - 0.15 12.4 0.0 0.32 11.4 0.0 1.5 1 0 0 1 1 1 0 PDZ domain PDZ_4 PF17816.1 EMC90161.1 - 0.16 12.3 0.0 1 9.8 0.0 2.1 2 0 0 2 2 2 0 PDZ domain ANTH PF07651.16 EMC90162.1 - 1.1e-84 283.8 0.5 1.3e-84 283.5 0.5 1.1 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 EMC90162.1 - 1e-14 54.6 0.0 1.7e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 ENTH domain VHS PF00790.19 EMC90162.1 - 0.079 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 VHS domain Trypsin PF00089.26 EMC90163.1 - 8e-12 45.4 0.0 5.9e-09 36.1 0.0 2.6 1 1 1 2 2 2 2 Trypsin Trypsin_2 PF13365.6 EMC90163.1 - 1.6e-06 29.1 0.0 3.4e-06 28.0 0.0 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain LAP1C PF05609.12 EMC90163.1 - 0.01 15.0 0.0 0.018 14.1 0.0 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF316 PF03761.15 EMC90163.1 - 0.18 11.3 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 Chymotrypsin family Peptidase-S1 Malic_M PF03949.15 EMC90164.1 - 1.7e-92 309.3 0.1 2.1e-92 309.0 0.1 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EMC90164.1 - 7.7e-81 270.2 0.0 1.2e-80 269.6 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain RWD PF05773.22 EMC90165.1 - 5.7e-14 52.4 0.0 1.1e-13 51.5 0.0 1.5 1 0 0 1 1 1 1 RWD domain DUF1115 PF06544.12 EMC90165.1 - 1.4e-13 51.2 0.1 6.3e-13 49.0 0.1 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1115) Acylphosphatase PF00708.18 EMC90165.1 - 0.063 13.7 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 Acylphosphatase THDPS_N_2 PF14805.6 EMC90165.1 - 0.064 13.5 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal PGM_PMM_I PF02878.16 EMC90166.1 - 6.2e-20 71.3 0.2 2.1e-08 33.9 0.0 3.6 2 2 1 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 EMC90166.1 - 4.8e-12 45.9 0.6 3.3e-11 43.2 0.3 2.4 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.16 EMC90166.1 - 0.00051 20.2 0.6 0.0018 18.5 0.6 2.0 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III DUF4385 PF14328.6 EMC90166.1 - 0.054 13.6 0.1 5.5 7.1 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4385) CinA_KH PF18146.1 EMC90166.1 - 0.092 12.9 2.9 2.9 8.1 0.0 2.9 3 0 0 3 3 3 0 Damage-inducible protein CinA KH domain Dopey_N PF04118.14 EMC90167.1 - 1.6e-106 355.9 0.5 1.1e-105 353.1 0.1 2.7 3 0 0 3 3 3 1 Dopey, N-terminal LRR_8 PF13855.6 EMC90169.1 - 1.3e-22 79.3 17.3 2.7e-16 59.1 7.0 3.0 2 1 1 3 3 3 3 Leucine rich repeat LRR_1 PF00560.33 EMC90169.1 - 1.6e-10 40.0 10.3 0.012 16.0 0.3 4.6 5 0 0 5 5 5 3 Leucine Rich Repeat LRR_4 PF12799.7 EMC90169.1 - 5.1e-10 39.4 12.1 0.00037 20.8 0.5 3.8 2 2 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EMC90169.1 - 0.00024 20.9 7.5 12 6.2 0.4 4.9 4 0 0 4 4 4 3 Leucine Rich repeat LRR_9 PF14580.6 EMC90169.1 - 0.005 16.4 0.6 0.01 15.4 0.3 1.6 2 0 0 2 2 2 1 Leucine-rich repeat LRRNT PF01462.18 EMC90169.1 - 0.016 14.9 0.3 0.029 14.0 0.3 1.5 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain RCC1 PF00415.18 EMC90170.1 - 1.2e-36 125.1 12.0 1.5e-11 44.7 0.1 4.8 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EMC90170.1 - 4.2e-32 110.7 7.0 1.1e-15 57.8 1.1 3.1 2 1 1 3 3 3 2 BTB/POZ domain RCC1_2 PF13540.6 EMC90170.1 - 1.4e-10 40.7 14.4 0.00016 21.4 0.0 6.3 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat Ank_5 PF13857.6 EMC90170.1 - 1.3e-09 38.1 0.0 8.3e-06 26.0 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC90170.1 - 2e-08 34.6 0.0 3.8e-05 24.2 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC90170.1 - 2.8e-08 34.3 0.0 8.2e-08 32.7 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMC90170.1 - 0.00019 21.6 0.0 1.7 9.4 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 EMC90170.1 - 0.001 19.4 0.0 0.29 11.7 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat SUKH-3 PF14433.6 EMC90170.1 - 0.11 13.0 0.1 38 4.7 0.0 3.9 3 2 2 5 5 5 0 SUKH-3 immunity protein DUF1265 PF06887.14 EMC90170.1 - 0.13 12.2 0.5 0.34 10.9 0.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1265) Transket_pyr PF02779.24 EMC90171.1 - 1.7e-43 148.3 0.0 2.3e-43 148.0 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EMC90171.1 - 5.7e-36 123.1 0.0 1.1e-35 122.2 0.0 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain PFOR_II PF17147.4 EMC90171.1 - 0.15 12.4 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II Hormone_recep PF00104.30 EMC90172.1 - 5e-17 62.2 0.3 7.1e-17 61.7 0.3 1.1 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Pkinase PF00069.25 EMC90173.1 - 2.3e-64 217.3 0.9 3.5e-64 216.7 0.9 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC90173.1 - 2.8e-33 115.3 0.1 5.5e-33 114.3 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC90173.1 - 3.2e-09 36.5 0.0 4.9e-06 26.1 0.0 2.6 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EMC90173.1 - 2.1e-06 27.8 0.0 0.038 13.9 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family FTA2 PF13095.6 EMC90173.1 - 7.4e-05 22.5 0.3 0.18 11.4 0.0 2.5 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EMC90173.1 - 0.00014 21.3 0.1 0.00026 20.4 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EMC90173.1 - 0.00073 19.2 2.8 0.0041 16.7 0.4 2.2 1 1 1 2 2 2 1 RIO1 family Kinase-PolyVal PF18762.1 EMC90173.1 - 0.023 14.7 1.0 0.049 13.6 1.0 1.5 1 0 0 1 1 1 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins Tubulin PF00091.25 EMC90173.1 - 0.044 14.0 0.0 0.084 13.1 0.0 1.3 1 0 0 1 1 1 0 Tubulin/FtsZ family, GTPase domain Mad3_BUB1_I_2 PF17014.5 EMC90174.1 - 0.012 15.7 1.0 0.018 15.2 0.2 1.6 2 0 0 2 2 2 0 Putative Mad3/BUB1 like region 1 protein Mad3_BUB1_I PF08311.12 EMC90174.1 - 0.019 14.9 0.3 0.034 14.1 0.1 1.6 2 1 0 2 2 2 0 Mad3/BUB1 homology region 1 TPR_2 PF07719.17 EMC90174.1 - 0.14 12.3 0.4 26 5.3 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMC90174.1 - 0.18 12.5 0.5 43 5.1 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat ELO PF01151.18 EMC90175.1 - 1.6e-63 214.5 28.2 1.9e-63 214.4 28.2 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family SH3BGR PF04908.15 EMC90176.1 - 6.6e-38 128.9 0.2 7.5e-38 128.7 0.2 1.0 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 EMC90176.1 - 1.7e-07 31.3 0.0 2.2e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin Lebercilin PF15619.6 EMC90177.1 - 1.1e-69 233.9 53.4 1.1e-69 233.9 53.4 2.2 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease FUSC PF04632.12 EMC90177.1 - 0.43 9.0 10.8 0.71 8.3 10.8 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family Golgin_A5 PF09787.9 EMC90177.1 - 1.9 7.9 55.2 0.13 11.7 18.0 3.1 2 1 1 3 3 3 0 Golgin subfamily A member 5 HMG14_17 PF01101.18 EMC90178.1 - 8.3e-22 78.0 20.3 1.1e-21 77.5 20.3 1.2 1 0 0 1 1 1 1 HMG14 and HMG17 DUF2477 PF10631.9 EMC90178.1 - 0.41 11.3 4.5 0.47 11.1 4.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2477) TT_ORF2 PF02957.15 EMC90178.1 - 0.82 10.6 6.8 1.1 10.2 6.8 1.3 1 0 0 1 1 1 0 TT viral ORF2 Bromodomain PF00439.25 EMC90179.1 - 6.9e-38 128.6 0.2 3.3e-18 65.5 0.0 2.7 2 0 0 2 2 2 2 Bromodomain WD40 PF00400.32 EMC90179.1 - 3e-33 113.3 15.1 3.2e-05 24.6 0.1 8.8 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC90179.1 - 0.00054 20.2 0.3 0.51 10.7 0.1 4.3 3 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain YccV-like PF08755.11 EMC90180.1 - 1.7e-24 86.2 0.1 3.3e-24 85.2 0.1 1.5 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like SIMPL PF04402.14 EMC90181.1 - 6.4e-06 26.8 0.0 6.5e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF541) Mei4 PF13971.6 EMC90182.1 - 9.8e-78 262.0 10.4 1.1e-77 261.8 10.4 1.0 1 0 0 1 1 1 1 Meiosis-specific protein Mei4 7tm_1 PF00001.21 EMC90183.1 - 7.9e-83 277.8 12.5 9.8e-83 277.5 12.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC90183.1 - 8.3e-11 41.8 10.2 7.7e-10 38.6 10.2 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC90183.1 - 2.4e-07 30.8 8.8 4e-05 23.5 5.4 2.2 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 EMC90183.1 - 1.5e-06 28.0 8.0 1.5e-06 28.0 8.0 2.3 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF1761 PF08570.10 EMC90183.1 - 0.33 11.2 9.8 0.46 10.7 0.1 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1761) SEA PF01390.20 EMC90184.1 - 3e-32 110.9 3.7 1.9e-16 60.0 0.4 2.5 2 0 0 2 2 2 2 SEA domain DUF4214 PF13946.6 EMC90184.1 - 0.026 14.6 0.0 0.06 13.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4214) Plasmod_Pvs28 PF06247.11 EMC90184.1 - 0.18 12.1 1.3 0.46 10.8 1.3 1.6 1 0 0 1 1 1 0 Pvs28 EGF domain EGF_3 PF12947.7 EMC90184.1 - 0.35 11.1 1.1 0.79 10.0 1.1 1.6 1 0 0 1 1 1 0 EGF domain EGF_MSP1_1 PF12946.7 EMC90184.1 - 1.6 8.8 4.3 3.8 7.6 4.3 1.7 1 0 0 1 1 1 0 MSP1 EGF domain 1 Myosin_head PF00063.21 EMC90185.1 - 2.3e-239 796.1 2.3 2.3e-239 796.1 2.3 1.8 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin-VI_CBD PF16521.5 EMC90185.1 - 1.2e-45 153.4 1.2 3.1e-44 148.9 0.0 3.5 4 0 0 4 4 4 1 Myosin VI cargo binding domain Myosin_N PF02736.19 EMC90185.1 - 0.00022 21.0 0.0 0.00042 20.1 0.0 1.5 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain IQ PF00612.27 EMC90185.1 - 0.0029 17.2 0.8 0.0082 15.8 0.8 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif AAA_16 PF13191.6 EMC90185.1 - 0.61 10.5 0.0 0.61 10.5 0.0 3.0 2 1 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 EMC90185.1 - 1.3 9.3 0.0 1.3 9.3 0.0 3.1 3 1 0 3 3 3 0 AAA domain BUD22 PF09073.10 EMC90185.1 - 6.6 6.0 38.6 12 5.0 38.7 1.4 1 1 0 1 1 1 0 BUD22 Peptidase_C48 PF02902.19 EMC90186.1 - 4e-33 115.1 5.0 8.5e-20 71.5 0.3 2.7 3 0 0 3 3 3 2 Ulp1 protease family, C-terminal catalytic domain CortBP2 PF09727.9 EMC90187.1 - 1.8e-61 207.4 26.0 1.8e-61 207.4 26.0 7.5 3 1 4 7 7 7 2 Cortactin-binding protein-2 T2SSF PF00482.23 EMC90187.1 - 7.2 6.6 6.2 7.1 6.6 0.1 3.7 4 0 0 4 4 4 0 Type II secretion system (T2SS), protein F CDC50 PF03381.15 EMC90188.1 - 8.9e-93 310.8 0.2 1.1e-92 310.6 0.2 1.0 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family COX7a PF02238.15 EMC90189.1 - 2e-07 31.3 0.0 2.7e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII MFS_1 PF07690.16 EMC90190.1 - 1.3e-57 195.4 34.3 2.5e-56 191.1 27.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMC90190.1 - 3.1e-06 26.3 27.5 0.00013 20.9 27.5 2.6 1 1 0 1 1 1 1 Sugar (and other) transporter GTP_EFTU PF00009.27 EMC90191.1 - 1.8e-54 184.2 0.0 2.5e-54 183.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EMC90191.1 - 2.3e-40 137.4 0.0 5e-40 136.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EMC90191.1 - 4.1e-15 55.9 1.9 6.3e-15 55.3 0.6 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EMC90191.1 - 0.00031 20.8 0.2 0.0083 16.2 0.2 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 EMC90191.1 - 0.017 15.0 1.2 0.031 14.2 0.2 2.0 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Dynamin_N PF00350.23 EMC90191.1 - 0.079 13.0 0.1 17 5.4 0.1 2.4 2 0 0 2 2 2 0 Dynamin family G-alpha PF00503.20 EMC90191.1 - 0.24 10.5 0.2 0.7 9.0 0.1 1.8 2 0 0 2 2 2 0 G-protein alpha subunit GIDA PF01134.22 EMC90192.1 - 3.5e-96 322.7 0.0 4.7e-96 322.3 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 EMC90192.1 - 2.2e-66 224.0 0.0 3.1e-66 223.6 0.0 1.2 1 0 0 1 1 1 1 GidA associated domain Hexapep_2 PF14602.6 EMC90192.1 - 0.056 13.2 0.5 0.11 12.3 0.5 1.5 1 0 0 1 1 1 0 Hexapeptide repeat of succinyl-transferase Mab-21 PF03281.14 EMC90193.1 - 1.4e-76 257.7 5.0 1.6e-76 257.5 5.0 1.0 1 0 0 1 1 1 1 Mab-21 protein DEAD PF00270.29 EMC90194.1 - 7.6e-39 133.3 0.0 2.1e-38 131.8 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC90194.1 - 2e-28 99.0 0.0 3.4e-27 95.0 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain KH_1 PF00013.29 EMC90194.1 - 4.4e-07 29.6 0.5 9.9e-07 28.5 0.5 1.6 1 0 0 1 1 1 1 KH domain ResIII PF04851.15 EMC90194.1 - 0.00089 19.3 0.0 0.0066 16.5 0.0 2.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit MOEP19 PF16005.5 EMC90194.1 - 0.0044 17.0 0.0 0.11 12.5 0.0 2.4 2 0 0 2 2 2 1 KH-like RNA-binding domain KCNQ_channel PF03520.14 EMC90195.1 - 4.6e-94 313.6 1.5 4.6e-94 313.6 1.5 1.6 2 0 0 2 2 2 1 KCNQ voltage-gated potassium channel Ion_trans PF00520.31 EMC90195.1 - 2.8e-26 92.2 10.7 4.1e-26 91.7 10.7 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 EMC90195.1 - 3e-14 52.8 5.7 8.1e-14 51.4 5.7 1.8 1 0 0 1 1 1 1 Ion channel IQ PF00612.27 EMC90195.1 - 1.7 8.7 5.1 1.1 9.2 0.1 2.8 2 0 0 2 2 2 0 IQ calmodulin-binding motif C2 PF00168.30 EMC90196.1 - 1.3e-39 134.7 0.0 5e-19 68.5 0.0 2.8 2 0 0 2 2 2 2 C2 domain PDZ_6 PF17820.1 EMC90196.1 - 9.1e-10 38.2 0.0 1.9e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 EMC90196.1 - 1.7e-09 37.9 0.0 3.7e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 PDZ domain FYVE_2 PF02318.16 EMC90196.1 - 1.2e-07 32.0 7.0 3.5e-07 30.4 7.0 1.8 1 0 0 1 1 1 1 FYVE-type zinc finger zf-piccolo PF05715.13 EMC90196.1 - 9.4 6.5 11.3 25 5.1 11.3 1.8 1 0 0 1 1 1 0 Piccolo Zn-finger Asparaginase_2 PF01112.18 EMC90197.1 - 1e-116 389.3 3.7 1.2e-116 389.0 3.7 1.0 1 0 0 1 1 1 1 Asparaginase OGFr_N PF04664.13 EMC90198.1 - 2.8e-102 340.6 7.9 3.8e-102 340.2 7.9 1.2 1 0 0 1 1 1 1 Opioid growth factor receptor (OGFr) conserved region Glyco_transf_43 PF03360.16 EMC90199.1 - 9.9e-37 126.8 0.1 1.1e-36 126.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 43 ArfGap PF01412.18 EMC90200.1 - 6.2e-33 113.3 0.1 6.2e-33 113.3 0.1 2.1 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf DUF2151 PF10221.9 EMC90200.1 - 0.034 12.7 4.9 0.057 12.0 4.9 1.4 1 0 0 1 1 1 0 Cell cycle and development regulator EMC3_TMCO1 PF01956.16 EMC90200.1 - 0.14 11.9 0.0 0.14 11.9 0.0 2.2 2 1 0 2 2 1 0 Integral membrane protein EMC3/TMCO1-like CDC45 PF02724.14 EMC90200.1 - 0.17 10.2 4.7 0.22 9.8 4.7 1.2 1 0 0 1 1 1 0 CDC45-like protein GAGA_bind PF06217.12 EMC90200.1 - 0.27 11.5 6.7 0.52 10.6 6.7 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family SpoVR PF04293.13 EMC90200.1 - 0.5 9.0 5.5 0.77 8.4 5.5 1.2 1 0 0 1 1 1 0 SpoVR like protein Presenilin PF01080.17 EMC90200.1 - 0.95 8.2 7.7 1.6 7.4 7.7 1.3 1 0 0 1 1 1 0 Presenilin NARP1 PF12569.8 EMC90200.1 - 1.3 7.9 14.9 1.9 7.3 14.9 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SR-25 PF10500.9 EMC90200.1 - 1.6 8.3 22.3 0.016 14.8 13.7 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF913 PF06025.12 EMC90200.1 - 1.9 7.4 6.1 3.4 6.6 6.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) ALMT PF11744.8 EMC90200.1 - 2.3 6.9 5.1 3.6 6.3 5.1 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Membralin PF09746.9 EMC90200.1 - 3.3 6.7 4.0 5.3 6.0 4.0 1.2 1 0 0 1 1 1 0 Tumour-associated protein CPSF100_C PF13299.6 EMC90200.1 - 9.7 6.3 11.8 1.7 8.8 7.4 1.9 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF1674 PF07896.12 EMC90203.1 - 4.6e-20 71.8 5.2 4.6e-20 71.8 5.2 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1674) DUF676 PF05057.14 EMC90204.1 - 6.5e-61 205.6 0.0 1.2e-60 204.8 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF3657 PF12394.8 EMC90204.1 - 2.1e-19 69.8 3.5 4.5e-19 68.8 1.9 2.6 2 0 0 2 2 2 1 Protein FAM135 Palm_thioest PF02089.15 EMC90204.1 - 2.4e-08 34.1 0.0 5.2e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 EMC90204.1 - 2.8e-05 24.0 0.0 6.3e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein LCAT PF02450.15 EMC90204.1 - 0.00099 18.4 0.1 0.002 17.4 0.1 1.4 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase LMBR1 PF04791.16 EMC90206.1 - 9.6e-24 84.2 19.9 4.2e-22 78.7 19.9 2.3 1 1 0 1 1 1 1 LMBR1-like membrane protein TMEM132D_C PF15706.5 EMC90206.1 - 0.027 14.3 0.3 0.33 10.8 0.3 2.8 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF4131 PF13567.6 EMC90206.1 - 0.3 10.7 16.6 5.7 6.6 4.4 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4131) WBP-1 PF11669.8 EMC90206.1 - 5.5 7.7 5.9 49 4.6 0.0 3.6 4 0 0 4 4 4 0 WW domain-binding protein 1 7tm_2 PF00002.24 EMC90207.1 - 4.5e-59 199.7 15.3 7.1e-59 199.1 15.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.5 EMC90207.1 - 4e-35 121.2 0.2 6.3e-35 120.5 0.2 1.3 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain TSP_1 PF00090.19 EMC90207.1 - 7.2e-34 115.8 78.3 1e-12 48.1 8.4 5.8 5 1 0 5 5 5 3 Thrombospondin type 1 domain GPS PF01825.21 EMC90207.1 - 4.5e-14 52.7 3.1 4.5e-14 52.7 3.1 2.6 3 0 0 3 3 3 1 GPCR proteolysis site, GPS, motif HRM PF02793.22 EMC90207.1 - 3.4e-07 30.5 0.4 3.4e-07 30.5 0.4 4.3 3 1 0 3 3 3 1 Hormone receptor domain Peptidase_S9_N PF02897.15 EMC90208.1 - 0.031 13.1 0.0 0.037 12.8 0.0 1.1 1 0 0 1 1 1 0 Prolyl oligopeptidase, N-terminal beta-propeller domain EGF PF00008.27 EMC90210.1 - 5.9e-70 231.1 148.4 5.3e-09 36.2 4.9 11.3 11 0 0 11 11 11 11 EGF-like domain hEGF PF12661.7 EMC90210.1 - 1.1e-46 155.9 129.5 1.1e-05 25.9 6.5 12.4 11 0 0 11 11 11 11 Human growth factor-like EGF EGF_CA PF07645.15 EMC90210.1 - 1.1e-25 89.5 157.6 1.2e-05 25.4 3.2 11.4 8 3 3 11 11 11 10 Calcium-binding EGF domain EGF_2 PF07974.13 EMC90210.1 - 9.3e-10 38.7 170.1 0.00024 21.4 7.4 11.5 11 0 0 11 11 11 7 EGF-like domain FXa_inhibition PF14670.6 EMC90210.1 - 2e-09 37.6 125.2 0.086 13.1 5.7 11.8 5 5 6 11 11 11 9 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 EMC90210.1 - 2e-08 34.3 129.5 0.11 12.7 8.1 12.0 9 3 2 11 11 11 9 EGF domain cEGF PF12662.7 EMC90210.1 - 0.0025 17.7 14.0 0.0096 15.8 4.7 13.4 13 3 0 13 13 13 7 Complement Clr-like EGF-like DUF1846 PF08903.11 EMC90211.1 - 0.11 11.1 0.0 0.11 11.1 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1846) Y_phosphatase PF00102.27 EMC90212.1 - 2.3e-08 33.9 0.0 1.1e-07 31.7 0.0 1.8 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EMC90212.1 - 1e-07 31.8 0.0 1.5e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Gln-synt_C PF00120.24 EMC90213.1 - 9.8e-73 245.1 0.0 1.6e-72 244.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 EMC90213.1 - 2.6e-07 30.3 0.4 2.3e-06 27.3 0.1 2.6 2 1 0 2 2 2 1 Glutamine synthetase, beta-Grasp domain Gln-synt_N_2 PF16952.5 EMC90213.1 - 7.7e-05 22.5 0.0 0.00015 21.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase N-terminal domain DUF1236 PF06823.12 EMC90214.1 - 0.89 9.5 7.2 9.3 6.2 0.3 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1236) zf-C3HC4_3 PF13920.6 EMC90216.1 - 3.2e-10 39.7 5.0 8.5e-10 38.3 5.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC90216.1 - 1.4e-09 37.6 8.1 1.4e-09 37.6 8.1 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMC90216.1 - 1.9e-09 37.7 10.1 1.9e-09 37.7 10.1 2.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EMC90216.1 - 9.3e-09 35.0 7.3 2.1e-08 33.9 7.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMC90216.1 - 9e-08 32.0 2.0 9e-08 32.0 2.0 2.1 1 1 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 EMC90216.1 - 9.6e-07 29.0 7.5 9.6e-07 29.0 7.5 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EMC90216.1 - 5.4e-06 26.3 5.3 5.4e-06 26.3 5.3 2.0 2 0 0 2 2 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC90216.1 - 1.9e-05 24.4 8.5 0.0026 17.6 9.4 2.5 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EMC90216.1 - 0.00012 22.1 8.2 0.00012 22.1 8.2 1.9 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-Di19 PF05605.12 EMC90216.1 - 0.035 14.4 2.0 6.4 7.2 0.4 2.8 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-RING_6 PF14835.6 EMC90216.1 - 0.042 13.7 4.4 0.09 12.7 4.4 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 EMC90216.1 - 0.065 13.3 4.5 0.16 12.0 4.5 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Siva PF05458.12 EMC90216.1 - 0.14 11.9 5.5 0.14 11.9 3.6 1.9 1 1 0 1 1 1 0 Cd27 binding protein (Siva) zf-Nse PF11789.8 EMC90216.1 - 0.23 11.3 1.5 0.46 10.3 1.5 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Baculo_IE-1 PF05290.11 EMC90216.1 - 0.48 10.4 5.1 0.8 9.7 5.1 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) KH_1 PF00013.29 EMC90217.1 - 1.9e-09 37.2 0.0 3.5e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 KH domain Qua1 PF16274.5 EMC90217.1 - 9.6e-08 31.8 4.3 9.6e-08 31.8 4.3 2.2 2 0 0 2 2 2 1 Qua1 domain DNA_primase_lrg PF04104.14 EMC90219.1 - 3.9e-96 321.5 0.0 7.6e-96 320.6 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Ras PF00071.22 EMC90220.1 - 5.2e-53 179.0 1.3 8.3e-53 178.3 1.3 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC90220.1 - 3.7e-33 114.3 0.6 7.3e-33 113.3 0.4 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC90220.1 - 2.9e-10 39.9 0.8 3.9e-10 39.5 0.8 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMC90220.1 - 9.6e-07 28.9 0.1 2.1e-06 27.8 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMC90220.1 - 6.7e-05 22.5 0.4 0.00011 21.8 0.4 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EMC90220.1 - 9.3e-05 22.4 2.4 0.014 15.3 0.2 2.3 1 1 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EMC90220.1 - 0.00055 19.4 0.2 0.00088 18.7 0.2 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 EMC90220.1 - 0.0008 19.3 3.0 0.0014 18.4 0.4 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein YwhD PF08741.10 EMC90220.1 - 0.021 14.5 0.0 0.035 13.8 0.0 1.4 1 0 0 1 1 1 0 YwhD family FeoB_N PF02421.18 EMC90220.1 - 0.026 14.1 0.2 1.6 8.2 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.5 EMC90220.1 - 0.078 13.0 0.3 0.21 11.6 0.3 1.6 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain FAM184 PF15665.5 EMC90221.1 - 0.0053 16.6 0.9 0.0053 16.6 0.9 1.9 2 0 0 2 2 2 1 Family with sequence similarity 184, A and B DUF4347 PF14252.6 EMC90221.1 - 0.025 14.5 0.1 0.085 12.7 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4347) PIN_11 PF18479.1 EMC90222.1 - 1.3e-64 215.7 0.4 3.8e-64 214.2 0.0 2.1 2 0 0 2 2 2 1 PIN like domain zf-DBF PF07535.12 EMC90222.1 - 0.0033 17.5 1.0 0.0033 17.5 1.0 5.8 5 0 0 5 5 5 1 DBF zinc finger zf-C2H2_4 PF13894.6 EMC90222.1 - 0.22 12.5 89.0 0.38 11.7 2.2 13.4 14 0 0 14 14 14 0 C2H2-type zinc finger DUF5100 PF17029.5 EMC90222.1 - 2.4 8.0 7.8 6.4 6.6 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF5100) BEN PF10523.9 EMC90223.1 - 1.1e-12 48.0 0.0 2.1e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 BEN domain T3SS_needle_F PF09392.10 EMC90223.1 - 0.026 14.7 0.5 0.078 13.2 0.5 1.8 1 0 0 1 1 1 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF DUF1087 PF06465.13 EMC90223.1 - 0.051 13.6 0.4 0.13 12.4 0.0 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1087) bZIP_2 PF07716.15 EMC90223.1 - 0.18 11.9 0.4 0.18 11.9 0.4 1.8 2 0 0 2 2 2 0 Basic region leucine zipper Spectrin PF00435.21 EMC90225.1 - 8e-222 720.6 477.6 1.9e-16 60.5 7.3 42.0 40 3 4 44 44 42 33 Spectrin repeat CH PF00307.31 EMC90225.1 - 1.7e-43 147.2 12.7 2.7e-22 79.0 0.4 6.7 6 0 0 6 6 6 2 Calponin homology (CH) domain GAS2 PF02187.17 EMC90225.1 - 2.1e-30 104.6 0.4 8.6e-30 102.6 0.4 2.2 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain Spectrin_like PF18373.1 EMC90225.1 - 1.6e-29 101.8 0.7 1.6e-29 101.8 0.7 9.0 9 0 0 9 9 8 1 Spectrin like domain SH3_10 PF17902.1 EMC90225.1 - 3.2e-20 71.9 0.2 1.1e-19 70.3 0.2 2.0 1 0 0 1 1 1 1 SH3 domain EF-hand_1 PF00036.32 EMC90225.1 - 9.4e-12 43.6 2.3 0.0001 21.6 0.8 3.1 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EMC90225.1 - 7.9e-11 41.0 1.6 0.00037 20.2 0.4 3.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 EMC90225.1 - 1.2e-09 38.5 1.0 1.2e-09 38.5 1.0 5.1 4 0 0 4 4 3 1 EF-hand domain pair EF-hand_8 PF13833.6 EMC90225.1 - 3.9e-08 33.0 0.6 3.4e-06 26.8 0.1 3.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EMC90225.1 - 1.5e-07 30.6 4.5 5.1e-05 22.6 1.1 3.1 2 0 0 2 2 2 2 EF hand CAMSAP_CH PF11971.8 EMC90225.1 - 5.2e-07 29.4 0.7 0.0049 16.7 0.0 4.2 3 0 0 3 3 3 2 CAMSAP CH domain Laminin_II PF06009.12 EMC90225.1 - 0.011 15.7 0.2 0.011 15.7 0.2 30.9 23 8 10 36 36 35 0 Laminin Domain II HTH_57 PF18679.1 EMC90225.1 - 0.016 15.5 1.7 1.2 9.5 1.7 4.6 1 0 0 1 1 1 0 ThcOx helix turn helix domain DUF5304 PF17230.2 EMC90225.1 - 9 6.5 17.1 0.9 9.8 0.4 7.2 5 1 1 6 6 6 0 Family of unknown function (DUF5304) Collagen PF01391.18 EMC90226.1 - 3e-62 206.3 222.9 2e-09 37.0 24.6 8.2 3 3 5 8 8 8 8 Collagen triple helix repeat (20 copies) VWA PF00092.28 EMC90226.1 - 1e-42 146.4 0.1 1.5e-42 145.8 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EMC90226.1 - 2.5e-14 53.8 0.0 4e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Laminin_G_3 PF13385.6 EMC90226.1 - 0.00045 20.4 0.0 0.00083 19.5 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily VWA_3 PF13768.6 EMC90226.1 - 0.0024 17.8 0.0 0.0035 17.3 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Laminin_G_2 PF02210.24 EMC90226.1 - 0.014 16.0 0.0 0.027 15.1 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain TGFb_propeptide PF00688.18 EMC90227.1 - 1.3e-92 310.0 0.0 2.1e-92 309.3 0.0 1.3 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 EMC90227.1 - 2e-37 128.3 0.6 5.6e-37 126.9 0.5 1.9 2 0 0 2 2 2 1 Transforming growth factor beta like domain YkuD_2 PF13645.6 EMC90227.1 - 0.17 11.3 1.1 0.31 10.5 0.3 1.8 2 0 0 2 2 2 0 L,D-transpeptidase catalytic domain HMGL-like PF00682.19 EMC90228.1 - 1.7e-66 224.5 0.0 2e-66 224.3 0.0 1.0 1 0 0 1 1 1 1 HMGL-like 7tm_1 PF00001.21 EMC90230.1 - 7.4e-58 195.9 22.0 9.2e-58 195.6 22.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Orexin_rec2 PF03827.13 EMC90230.1 - 5.5e-29 99.9 3.3 5.9e-29 99.8 1.3 2.1 2 0 0 2 2 2 1 Orexin receptor type 2 7TM_GPCR_Srsx PF10320.9 EMC90230.1 - 0.00018 21.0 21.2 0.0007 19.0 21.2 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 EMC90230.1 - 0.00038 20.3 9.8 0.00038 20.3 9.8 1.8 2 0 0 2 2 2 1 Olfactory receptor DUF5453 PF17534.2 EMC90230.1 - 0.41 10.6 4.5 0.12 12.3 1.2 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5453) FAM83 PF07894.12 EMC90231.1 - 1.7e-106 355.8 0.1 4.7e-106 354.3 0.1 1.8 1 0 0 1 1 1 1 FAM83 A-H PLDc_2 PF13091.6 EMC90231.1 - 6.3e-10 39.1 0.2 1.2e-09 38.1 0.2 1.5 1 0 0 1 1 1 1 PLD-like domain Regulator_TrmB PF11495.8 EMC90231.1 - 0.018 14.2 0.0 0.029 13.5 0.0 1.3 1 0 0 1 1 1 0 Archaeal transcriptional regulator TrmB Peptidase_C1 PF00112.23 EMC90232.1 - 5.7e-54 183.5 8.7 5.7e-54 183.5 8.7 1.9 2 0 0 2 2 2 1 Papain family cysteine protease Pacifastin_I PF05375.13 EMC90232.1 - 0.00062 19.4 2.6 0.00062 19.4 2.6 2.4 2 0 0 2 2 2 1 Pacifastin inhibitor (LCMII) Somatomedin_B PF01033.17 EMC90232.1 - 0.013 15.9 16.9 0.013 15.9 16.9 2.6 2 0 0 2 2 2 0 Somatomedin B domain Propeptide_C1 PF08127.13 EMC90232.1 - 0.049 13.5 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Peptidase family C1 propeptide Peptidase_C1_2 PF03051.15 EMC90232.1 - 0.11 11.3 3.7 0.082 11.7 0.9 2.1 2 1 1 3 3 3 0 Peptidase C1-like family MLIP PF15274.6 EMC90233.1 - 8.1e-121 402.6 4.6 2.4e-120 401.1 4.6 1.7 1 1 0 1 1 1 1 Muscular LMNA-interacting protein LRR_8 PF13855.6 EMC90234.1 - 2.3e-32 110.5 36.2 5.5e-09 35.7 2.9 6.3 2 2 4 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 EMC90234.1 - 2e-28 98.0 47.1 2.7e-05 24.5 1.3 8.4 5 1 1 8 8 8 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC90234.1 - 3e-10 39.9 17.1 0.00028 20.4 2.0 4.7 2 1 2 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 EMC90234.1 - 0.037 14.5 39.9 10 7.1 0.1 12.3 9 3 2 11 11 11 0 Leucine Rich Repeat Tropomyosin_1 PF12718.7 EMC90234.1 - 0.058 13.5 3.1 0.14 12.3 3.1 1.6 1 0 0 1 1 1 0 Tropomyosin like HMw1_D2 PF18254.1 EMC90234.1 - 0.17 12.3 1.3 3.7 8.0 0.0 3.8 4 1 0 4 4 4 0 HMW1 domain 2 H-kinase_dim PF02895.14 EMC90234.1 - 0.85 10.0 5.2 0.36 11.3 0.3 2.9 3 2 0 3 3 3 0 Signal transducing histidine kinase, homodimeric domain Elongin_A PF06881.11 EMC90235.1 - 3e-25 88.8 0.5 3e-25 88.8 0.5 3.6 4 0 0 4 4 4 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Med26 PF08711.11 EMC90235.1 - 2e-10 40.5 0.7 2e-10 40.5 0.7 2.2 2 0 0 2 2 2 1 TFIIS helical bundle-like domain Kelch_1 PF01344.25 EMC90236.1 - 1.7e-47 158.7 11.8 1.9e-12 46.6 0.1 6.5 5 1 0 5 5 5 5 Kelch motif Kelch_6 PF13964.6 EMC90236.1 - 4.2e-34 115.7 3.5 9.9e-08 32.0 0.1 6.0 3 1 3 6 6 6 5 Kelch motif BACK PF07707.15 EMC90236.1 - 2.2e-25 88.7 0.7 4.6e-25 87.7 0.1 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_3 PF13415.6 EMC90236.1 - 6.1e-23 80.6 0.5 2.5e-06 27.6 0.0 5.0 4 0 0 4 4 4 4 Galactose oxidase, central domain BTB PF00651.31 EMC90236.1 - 7.6e-23 80.9 0.6 1.9e-22 79.6 0.4 1.8 1 1 1 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 EMC90236.1 - 7.7e-20 70.0 5.4 2.7e-07 30.3 0.1 6.6 6 1 0 6 6 6 3 Kelch motif Kelch_4 PF13418.6 EMC90236.1 - 2.2e-17 62.8 0.2 0.00033 20.6 0.0 5.5 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC90236.1 - 2e-12 46.8 6.5 0.0017 18.3 0.1 5.4 5 0 0 5 5 5 4 Kelch motif Glyoxal_oxid_N PF07250.11 EMC90236.1 - 0.00037 19.8 1.0 0.072 12.3 0.2 2.4 2 1 0 2 2 2 2 Glyoxal oxidase N-terminus DUF1668 PF07893.13 EMC90236.1 - 0.05 12.9 0.0 0.21 10.9 0.0 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF1668) DnaJ PF00226.31 EMC90236.1 - 0.1 12.7 0.0 0.85 9.8 0.0 2.3 2 0 0 2 2 2 0 DnaJ domain ThiG PF05690.14 EMC90236.1 - 0.17 11.2 0.0 0.3 10.4 0.0 1.3 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG GCS PF03074.16 EMC90237.1 - 1.4e-180 600.5 0.0 1.7e-180 600.2 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase GCS2 PF04107.13 EMC90237.1 - 0.032 13.6 0.0 0.067 12.5 0.0 1.4 1 0 0 1 1 1 0 Glutamate-cysteine ligase family 2(GCS2) SANT_DAMP1_like PF16282.5 EMC90237.1 - 0.069 13.4 0.0 0.2 11.9 0.0 1.8 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 GCM PF03615.15 EMC90238.1 - 2.7e-70 234.7 5.3 3.5e-70 234.3 5.3 1.1 1 0 0 1 1 1 1 GCM motif protein F-box-like PF12937.7 EMC90239.1 - 9.9e-12 44.6 1.4 1.8e-11 43.7 1.4 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMC90239.1 - 2.2e-08 33.7 1.6 4.1e-08 32.9 1.6 1.5 1 0 0 1 1 1 1 F-box domain MIT PF04212.18 EMC90239.1 - 0.00072 19.6 0.5 0.0013 18.7 0.5 1.4 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Xol-1_N PF09108.10 EMC90239.1 - 0.057 13.3 0.1 0.096 12.5 0.1 1.2 1 0 0 1 1 1 0 Switch protein XOL-1, N-terminal Pkinase PF00069.25 EMC90240.1 - 2.2e-78 263.3 0.0 2.9e-78 262.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC90240.1 - 4.3e-37 127.8 0.1 2e-36 125.6 0.1 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EMC90240.1 - 0.00077 18.5 0.1 0.0015 17.6 0.1 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Anoct_dimer PF16178.5 EMC90240.1 - 0.0049 16.6 0.6 0.01 15.6 0.6 1.5 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Dscam_C PF12355.8 EMC90240.1 - 1.3 10.0 6.3 10 7.1 0.5 2.7 2 0 0 2 2 2 0 Down syndrome cell adhesion molecule C terminal GST_N PF02798.20 EMC90241.1 - 9.8e-20 70.7 0.0 1.7e-19 69.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EMC90241.1 - 2.9e-18 65.9 0.0 5.2e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EMC90241.1 - 3.3e-17 62.5 0.0 5.5e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EMC90241.1 - 0.0036 17.3 0.6 0.0097 15.9 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EMC90241.1 - 0.017 15.5 0.0 0.031 14.7 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EMC90242.1 - 6e-20 71.3 0.0 9.2e-20 70.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EMC90242.1 - 6.3e-17 61.6 0.0 1.1e-16 60.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EMC90242.1 - 8e-17 61.4 0.0 1.7e-16 60.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EMC90242.1 - 0.028 14.5 0.0 0.054 13.5 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EMC90242.1 - 0.064 13.7 0.0 0.32 11.4 0.0 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain Sa_NUDIX PF18167.1 EMC90242.1 - 0.12 12.1 0.0 1 9.1 0.0 2.0 1 1 1 2 2 2 0 SMODS-associated NUDIX domain GST_C_3 PF14497.6 EMC90243.1 - 1e-18 67.3 0.0 1.9e-18 66.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EMC90243.1 - 2.8e-16 59.5 0.1 4.1e-16 59.0 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EMC90243.1 - 1.7e-15 57.1 0.0 3.6e-15 56.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EMC90243.1 - 0.1 12.7 0.0 0.23 11.5 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EMC90243.1 - 0.14 12.6 0.0 0.41 11.1 0.0 1.7 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EMC90244.1 - 6e-18 64.9 0.1 2.3e-17 63.0 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EMC90244.1 - 1.2e-16 60.8 0.0 2.3e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EMC90244.1 - 9e-16 57.9 0.1 2.1e-15 56.7 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EMC90244.1 - 0.033 14.6 0.0 0.1 13.0 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EMC90244.1 - 0.1 12.6 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EMC90245.1 - 4.3e-18 65.3 0.0 7.1e-18 64.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EMC90245.1 - 9.7e-18 64.2 0.0 1.7e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EMC90245.1 - 1.3e-16 60.7 0.0 2e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EMC90245.1 - 0.00041 20.7 0.0 0.00077 19.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EMC90245.1 - 0.0094 16.0 0.0 0.018 15.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tmemb_14 PF03647.13 EMC90246.1 - 2.2e-29 102.0 8.0 2.5e-29 101.8 8.0 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C DUF2232 PF09991.9 EMC90246.1 - 0.13 11.5 6.2 0.15 11.2 6.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) PTCB-BRCT PF12738.7 EMC90247.1 - 2.5e-19 69.0 4.9 4.4e-17 61.8 1.2 3.5 3 0 0 3 3 3 1 twin BRCT domain BRCT_2 PF16589.5 EMC90247.1 - 1.7e-17 63.6 0.9 1.3e-08 35.1 0.1 3.5 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EMC90247.1 - 2.2e-16 60.0 4.9 5e-05 23.6 0.2 4.0 3 1 0 3 3 3 3 BRCA1 C Terminus (BRCT) domain BRCT_3 PF18428.1 EMC90247.1 - 0.0058 16.7 8.7 0.43 10.7 0.3 4.4 4 0 0 4 4 4 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EMC90247.1 - 0.018 15.3 1.4 0.09 13.1 0.4 2.6 3 0 0 3 3 3 0 DNA ligase 3 BRCT domain DUF1664 PF07889.12 EMC90247.1 - 0.032 14.3 0.2 0.099 12.7 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Barwin PF00967.17 EMC90247.1 - 0.035 14.0 0.2 0.19 11.6 0.0 2.3 3 0 0 3 3 3 0 Barwin family RTT107_BRCT_5 PF16770.5 EMC90247.1 - 0.045 13.6 0.1 3.2 7.7 0.0 3.1 3 1 0 3 3 3 0 Regulator of Ty1 transposition protein 107 BRCT domain Spectrin PF00435.21 EMC90247.1 - 0.13 12.7 0.9 4.7 7.8 1.8 2.6 1 1 0 1 1 1 0 Spectrin repeat PRKG1_interact PF15898.5 EMC90247.1 - 3.3 8.6 7.6 0.38 11.7 1.6 2.5 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Fibrinogen_C PF00147.18 EMC90248.1 - 3.2e-69 233.1 7.4 5.2e-69 232.4 7.4 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Spc29 PF17082.5 EMC90248.1 - 0.33 10.7 19.0 0.48 10.2 3.8 2.8 1 1 2 3 3 3 0 Spindle Pole Component 29 SlyX PF04102.12 EMC90248.1 - 0.34 11.6 25.8 0.19 12.4 6.5 3.2 1 1 2 3 3 3 0 SlyX DivIC PF04977.15 EMC90248.1 - 0.43 10.4 19.6 0.059 13.1 3.2 3.6 1 1 1 3 3 3 0 Septum formation initiator Phage_lysis PF03245.13 EMC90248.1 - 6.2 7.0 13.6 0.12 12.5 5.7 2.2 2 2 1 3 3 3 0 Bacteriophage Rz lysis protein CUB PF00431.20 EMC90249.1 - 6.1e-15 55.5 0.0 8.6e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 CUB domain Sushi PF00084.20 EMC90249.1 - 2.4e-08 34.4 0.1 3.9e-08 33.8 0.1 1.4 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) 5_nucleotid PF05761.14 EMC90250.1 - 4.2e-29 101.8 0.1 5e-29 101.5 0.1 1.0 1 0 0 1 1 1 1 5' nucleotidase family CUB PF00431.20 EMC90251.1 - 3.2e-283 919.0 0.0 9.4e-28 96.8 0.0 13.4 13 0 0 13 13 13 13 CUB domain Sushi PF00084.20 EMC90251.1 - 6.3e-250 808.1 164.7 7.2e-12 45.7 0.5 27.4 27 0 0 27 27 27 27 Sushi repeat (SCR repeat) CUB_2 PF02408.20 EMC90251.1 - 1.3e-20 73.3 10.6 0.0059 16.4 0.0 10.6 12 0 0 12 12 12 6 CUB-like domain fn3 PF00041.21 EMC90252.1 - 8.2e-87 285.7 13.5 8.9e-19 67.6 0.1 6.3 6 0 0 6 6 6 5 Fibronectin type III domain I-set PF07679.16 EMC90252.1 - 5.1e-68 225.2 9.9 6.7e-21 74.2 0.0 8.3 9 0 0 9 9 8 7 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC90252.1 - 5.1e-50 168.0 0.6 1e-12 48.5 0.0 8.1 8 0 0 8 8 7 6 Immunoglobulin domain Ig_2 PF13895.6 EMC90252.1 - 1.6e-33 114.9 0.5 1.6e-07 31.6 0.0 7.2 7 0 0 7 7 7 5 Immunoglobulin domain ig PF00047.25 EMC90252.1 - 1.4e-23 82.8 9.4 1.1e-07 31.9 0.0 8.0 8 0 0 8 8 8 5 Immunoglobulin domain V-set PF07686.17 EMC90252.1 - 1.1e-16 61.0 17.4 0.016 15.4 0.1 10.9 8 4 1 9 9 8 3 Immunoglobulin V-set domain Tissue_fac PF01108.17 EMC90252.1 - 1e-12 47.8 0.9 0.0039 17.0 0.0 5.4 6 0 0 6 6 6 4 Tissue factor Pur_ac_phosph_N PF16656.5 EMC90252.1 - 7.6e-11 42.4 11.0 0.027 15.0 0.8 7.5 7 0 0 7 7 7 4 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.12 EMC90252.1 - 8e-07 29.0 0.0 0.12 12.4 0.0 4.3 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Receptor_2B4 PF11465.8 EMC90252.1 - 8.2e-06 26.0 0.3 0.62 10.3 0.0 5.5 5 0 0 5 5 5 1 Natural killer cell receptor 2B4 Y_Y_Y PF07495.13 EMC90252.1 - 0.00039 20.3 1.8 20 5.2 0.0 6.7 8 0 0 8 8 8 0 Y_Y_Y domain fn3_2 PF16893.5 EMC90252.1 - 0.0012 18.9 0.0 9.7 6.4 0.0 4.1 3 0 0 3 3 3 1 Fibronectin type III domain Ig_5 PF16681.5 EMC90252.1 - 0.031 14.7 5.4 3.7 8.0 0.0 5.6 6 0 0 6 6 6 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Cadherin-like PF12733.7 EMC90252.1 - 0.032 14.8 0.5 8.9 6.9 0.1 3.6 3 0 0 3 3 3 0 Cadherin-like beta sandwich domain GBP_C PF02841.14 EMC90252.1 - 1.9 7.8 8.2 3.1 7.1 8.2 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain RhoGEF PF00621.20 EMC90253.1 - 1.1e-39 136.5 1.3 1.8e-39 135.8 0.5 1.9 2 0 0 2 2 2 1 RhoGEF domain BBS2_Mid PF14783.6 EMC90253.1 - 0.068 13.2 0.1 1.3 9.1 0.0 2.4 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region GKAP PF03359.13 EMC90255.1 - 7.1e-164 545.4 1.7 7.1e-164 545.4 1.7 2.6 3 0 0 3 3 3 1 Guanylate-kinase-associated protein (GKAP) protein Propep_M14 PF02244.16 EMC90256.1 - 0.1 13.0 1.5 0.32 11.4 0.0 2.5 3 0 0 3 3 3 0 Carboxypeptidase activation peptide TDRP PF15683.5 EMC90257.1 - 8.3e-73 243.2 9.3 9.2e-73 243.0 9.3 1.0 1 0 0 1 1 1 1 Testis development-related protein Elongin_A PF06881.11 EMC90258.1 - 0.00078 19.9 0.2 0.00078 19.9 0.2 1.8 2 0 0 2 2 2 1 RNA polymerase II transcription factor SIII (Elongin) subunit A F-box PF00646.33 EMC90258.1 - 0.0036 17.1 0.1 0.017 15.0 0.0 2.2 2 0 0 2 2 2 1 F-box domain FAM110_C PF14160.6 EMC90259.1 - 1.2e-35 123.0 0.7 1.2e-35 123.0 0.7 2.3 3 0 0 3 3 3 1 Centrosome-associated C terminus FAM110_N PF14161.6 EMC90259.1 - 2.8e-24 85.4 0.3 7.4e-24 84.0 0.1 1.8 2 0 0 2 2 2 1 Centrosome-associated N terminus LMWPc PF01451.21 EMC90260.1 - 7.5e-48 162.5 0.1 8.3e-48 162.4 0.1 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase TMEM206 PF15122.6 EMC90260.1 - 0.053 12.7 0.1 0.073 12.2 0.1 1.1 1 0 0 1 1 1 0 TMEM206 protein family FAM150 PF15129.6 EMC90261.1 - 5.8e-60 200.9 0.9 6.8e-60 200.7 0.9 1.1 1 0 0 1 1 1 1 FAM150 family RVT_1 PF00078.27 EMC90262.1 - 0.032 13.8 0.0 0.044 13.3 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) TMEM18 PF14770.6 EMC90263.1 - 8e-46 154.9 5.3 9e-46 154.7 5.3 1.0 1 0 0 1 1 1 1 Transmembrane protein 18 PDZ PF00595.24 EMC90264.1 - 6e-17 61.8 1.3 1e-16 61.0 1.3 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EMC90264.1 - 1e-09 38.1 0.2 2.4e-09 36.9 0.2 1.6 1 0 0 1 1 1 1 PDZ domain PH PF00169.29 EMC90264.1 - 2.2e-07 31.3 0.0 0.04 14.4 0.0 2.8 2 1 0 2 2 2 2 PH domain PDZ_2 PF13180.6 EMC90264.1 - 1.7e-05 25.1 0.1 4e-05 23.9 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PH_17 PF18012.1 EMC90264.1 - 8e-05 22.3 0.0 0.00015 21.4 0.0 1.5 1 0 0 1 1 1 1 PH domain Tricorn_PDZ PF14685.6 EMC90264.1 - 0.04 13.9 0.5 0.39 10.7 0.1 2.4 2 0 0 2 2 2 0 Tricorn protease PDZ domain An_peroxidase PF03098.15 EMC90265.1 - 2.8e-195 649.9 0.0 4.2e-195 649.3 0.0 1.3 1 0 0 1 1 1 1 Animal haem peroxidase I-set PF07679.16 EMC90265.1 - 3.3e-87 286.7 0.3 1.2e-20 73.3 0.0 4.4 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC90265.1 - 8.9e-77 253.7 5.8 1.1e-19 70.7 0.2 4.7 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 EMC90265.1 - 4.5e-50 167.9 2.6 1.5e-11 44.5 0.1 4.5 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 EMC90265.1 - 5.2e-43 145.1 1.0 2.8e-13 49.8 0.0 4.6 4 0 0 4 4 4 4 Immunoglobulin domain LRR_8 PF13855.6 EMC90265.1 - 2e-37 126.7 21.9 1.7e-17 62.9 3.6 3.7 1 1 2 3 3 3 3 Leucine rich repeat V-set PF07686.17 EMC90265.1 - 1.2e-22 80.1 11.7 0.0016 18.6 0.2 8.2 4 4 1 5 5 5 5 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC90265.1 - 3.6e-19 68.6 2.1 0.0011 18.9 0.0 4.7 4 0 0 4 4 4 4 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 EMC90265.1 - 5.3e-16 58.8 0.4 0.0013 19.1 0.1 5.3 5 0 0 5 5 4 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain LRR_4 PF12799.7 EMC90265.1 - 1.3e-15 57.3 21.3 1.2e-06 28.8 3.0 5.4 4 1 4 8 8 7 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC90265.1 - 3.1e-11 43.3 2.0 1.7e-09 37.7 0.1 2.7 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC90265.1 - 1.5e-10 40.8 2.5 2.9e-05 23.7 0.7 2.4 1 1 1 2 2 2 2 Leucine-rich repeat Ig_6 PF18452.1 EMC90265.1 - 4.6e-10 38.9 0.0 0.45 10.1 0.0 4.8 4 0 0 4 4 4 3 Immunoglobulin domain Ig_4 PF16680.5 EMC90265.1 - 1.5e-09 38.0 0.0 0.021 15.1 0.1 4.9 4 0 0 4 4 4 2 T-cell surface glycoprotein CD3 delta chain VWC PF00093.18 EMC90265.1 - 5e-08 33.1 18.0 5e-08 33.1 18.0 2.9 3 0 0 3 3 2 1 von Willebrand factor type C domain Ig_C17orf99 PF17736.1 EMC90265.1 - 1.8e-07 31.1 0.0 0.15 12.1 0.0 4.1 4 0 0 4 4 4 2 C17orf99 Ig domain Izumo-Ig PF16706.5 EMC90265.1 - 1.7e-05 24.7 0.4 5.8 7.0 0.0 4.5 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain PSP94 PF05825.11 EMC90265.1 - 0.00037 21.0 8.1 0.0011 19.5 8.1 1.7 1 0 0 1 1 1 1 Beta-microseminoprotein (PSP-94) LRR_1 PF00560.33 EMC90265.1 - 0.0014 18.9 9.8 9.6 7.2 0.2 5.6 4 0 0 4 4 4 0 Leucine Rich Repeat LRRCT PF01463.24 EMC90265.1 - 0.0033 17.8 0.1 0.033 14.7 0.0 2.7 2 0 0 2 2 2 1 Leucine rich repeat C-terminal domain Amnionless PF14828.6 EMC90265.1 - 0.055 12.3 9.2 0.094 11.5 9.2 1.2 1 0 0 1 1 1 0 Amnionless phiKZ_IP PF12699.7 EMC90265.1 - 0.12 11.4 0.2 0.2 10.8 0.2 1.2 1 0 0 1 1 1 0 phiKZ-like phage internal head proteins CFC PF09443.10 EMC90265.1 - 0.14 12.0 4.8 0.5 10.3 4.8 2.0 1 0 0 1 1 1 0 Cripto_Frl-1_Cryptic (CFC) fn1 PF00039.18 EMC90265.1 - 1.6 9.0 6.3 6.8 7.0 6.3 2.2 1 0 0 1 1 1 0 Fibronectin type I domain DUF812 PF05667.11 EMC90266.1 - 6.6e-05 22.0 9.0 6.6e-05 22.0 9.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) FapA PF03961.13 EMC90266.1 - 0.00051 18.8 6.5 0.00056 18.6 6.5 1.1 1 0 0 1 1 1 1 Flagellar Assembly Protein A APG6_N PF17675.1 EMC90266.1 - 0.00087 19.8 12.1 0.00087 19.8 12.1 1.6 2 0 0 2 2 1 1 Apg6 coiled-coil region DivIC PF04977.15 EMC90266.1 - 0.001 18.8 12.4 0.039 13.7 2.8 2.4 1 1 1 2 2 2 2 Septum formation initiator CALCOCO1 PF07888.11 EMC90266.1 - 0.002 17.1 8.8 0.0023 16.9 8.8 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like TMF_DNA_bd PF12329.8 EMC90266.1 - 0.003 17.5 15.3 0.0065 16.4 15.3 1.6 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding GAS PF13851.6 EMC90266.1 - 0.0031 16.9 10.1 0.0031 16.9 10.1 1.5 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding UPF0242 PF06785.11 EMC90266.1 - 0.013 15.6 12.4 0.019 15.1 12.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF3450 PF11932.8 EMC90266.1 - 0.014 14.7 9.6 0.017 14.5 9.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) HAUS-augmin3 PF14932.6 EMC90266.1 - 0.015 14.9 10.7 0.023 14.3 10.7 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Prefoldin PF02996.17 EMC90266.1 - 0.021 14.8 4.8 0.021 14.8 4.8 2.3 1 1 1 2 2 2 0 Prefoldin subunit ATG16 PF08614.11 EMC90266.1 - 0.022 15.0 14.4 0.041 14.1 14.3 1.7 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) GrpE PF01025.19 EMC90266.1 - 0.023 14.4 9.6 0.037 13.7 9.6 1.4 1 1 0 1 1 1 0 GrpE DUF4530 PF15039.6 EMC90266.1 - 0.032 14.4 2.7 0.042 14.0 2.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4530) TSC22 PF01166.18 EMC90266.1 - 0.032 14.5 12.0 0.56 10.5 1.9 2.7 1 1 1 2 2 2 0 TSC-22/dip/bun family DUF724 PF05266.14 EMC90266.1 - 0.046 13.6 10.0 0.069 13.0 10.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF1664 PF07889.12 EMC90266.1 - 0.054 13.5 7.7 0.067 13.2 6.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CUTL PF16557.5 EMC90266.1 - 0.063 13.5 0.7 0.15 12.2 0.7 1.7 1 0 0 1 1 1 0 CUT1-like DNA-binding domain of SATB DUF4407 PF14362.6 EMC90266.1 - 0.069 12.5 4.2 0.076 12.4 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Tho2 PF11262.8 EMC90266.1 - 0.077 12.2 11.5 0.033 13.4 7.8 1.8 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 DASH_Dam1 PF08653.10 EMC90266.1 - 0.089 12.6 5.8 1.6 8.6 0.6 2.9 1 1 1 2 2 2 0 DASH complex subunit Dam1 bZIP_1 PF00170.21 EMC90266.1 - 0.1 12.7 15.1 0.14 12.3 3.6 2.9 2 1 1 3 3 3 0 bZIP transcription factor BRE1 PF08647.11 EMC90266.1 - 0.11 12.5 12.8 0.13 12.4 11.6 1.8 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase FAM76 PF16046.5 EMC90266.1 - 0.14 11.5 7.2 0.19 11.0 7.2 1.2 1 0 0 1 1 1 0 FAM76 protein Atg14 PF10186.9 EMC90266.1 - 0.16 11.0 7.3 0.17 10.9 7.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 V_ATPase_I PF01496.19 EMC90266.1 - 0.22 9.4 7.6 0.23 9.3 7.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SlyX PF04102.12 EMC90266.1 - 0.23 12.1 6.8 0.4 11.3 5.2 2.2 1 1 1 2 2 2 0 SlyX Phage_GP20 PF06810.11 EMC90266.1 - 0.28 11.0 11.2 0.96 9.2 2.7 2.4 1 1 1 2 2 2 0 Phage minor structural protein GP20 Prefoldin_2 PF01920.20 EMC90266.1 - 0.28 11.2 13.7 1.1 9.2 3.5 2.4 1 1 1 2 2 2 0 Prefoldin subunit YabA PF06156.13 EMC90266.1 - 0.39 11.4 14.0 0.28 11.8 10.4 2.2 1 1 1 2 2 2 0 Initiation control protein YabA DUF1319 PF07028.11 EMC90266.1 - 0.4 10.9 8.6 0.7 10.1 3.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) Mod_r PF07200.13 EMC90266.1 - 0.48 10.5 14.9 0.81 9.8 14.0 1.8 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein XhlA PF10779.9 EMC90266.1 - 0.53 10.5 14.1 1.6 9.0 3.5 2.6 1 1 0 2 2 2 0 Haemolysin XhlA Uso1_p115_C PF04871.13 EMC90266.1 - 0.6 10.5 13.0 0.15 12.4 8.8 2.0 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region TMCO5 PF14992.6 EMC90266.1 - 0.72 9.4 15.8 0.54 9.8 14.0 1.5 1 1 0 1 1 1 0 TMCO5 family CENP-H PF05837.12 EMC90266.1 - 0.74 10.3 15.5 0.11 12.9 6.6 2.8 1 1 1 3 3 3 0 Centromere protein H (CENP-H) DUF16 PF01519.16 EMC90266.1 - 0.86 10.1 10.1 0.4 11.2 7.7 1.7 2 0 0 2 2 1 0 Protein of unknown function DUF16 DUF3251 PF11622.8 EMC90266.1 - 0.9 9.2 6.7 0.49 10.0 3.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3251) STATa_Ig PF18214.1 EMC90266.1 - 1 9.4 5.6 0.48 10.4 2.2 1.9 1 1 1 2 2 2 0 STATa Immunoglobulin-like domain NPV_P10 PF05531.12 EMC90266.1 - 1.3 9.5 9.4 68 4.0 9.3 3.1 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein ZapB PF06005.12 EMC90266.1 - 1.4 9.4 16.6 3 8.4 4.5 2.7 1 1 1 2 2 2 0 Cell division protein ZapB Noelin-1 PF12308.8 EMC90266.1 - 1.5 8.9 5.6 1.3 9.0 4.1 1.8 1 1 1 2 2 2 0 Neurogenesis glycoprotein zf-CCCH_6 PF18585.1 EMC90266.1 - 1.5 8.7 5.0 4.5 7.2 0.4 3.1 2 1 1 3 3 3 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 Med4 PF10018.9 EMC90266.1 - 2.1 8.0 11.3 6.5 6.4 3.0 2.2 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 CpxA_peri PF16527.5 EMC90266.1 - 2.2 8.7 6.5 4.9 7.5 3.4 2.0 1 1 1 2 2 2 0 Two-component sensor protein CpxA, periplasmic domain Cnn_1N PF07989.11 EMC90266.1 - 2.4 8.4 15.2 3.3 7.9 12.6 2.5 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 GBP_C PF02841.14 EMC90266.1 - 2.5 7.4 16.4 2.2 7.6 15.5 1.3 1 1 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Bac_small_YrzI PF09501.10 EMC90266.1 - 2.7 8.2 8.4 2.7 8.2 1.7 2.7 2 0 0 2 2 2 0 Probable sporulation protein (Bac_small_yrzI) eIF3_subunit PF08597.10 EMC90266.1 - 3.3 7.6 10.1 6.9 6.5 10.1 1.5 1 1 0 1 1 1 0 Translation initiation factor eIF3 subunit TMPIT PF07851.13 EMC90266.1 - 3.6 6.8 9.2 3 7.0 8.2 1.4 1 1 0 1 1 1 0 TMPIT-like protein zf-C4H2 PF10146.9 EMC90266.1 - 3.8 7.8 12.7 5 7.4 12.7 1.2 1 0 0 1 1 1 0 Zinc finger-containing protein Cep57_CLD_2 PF14197.6 EMC90266.1 - 4.8 7.3 12.8 0.88 9.7 3.6 2.7 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 DUF4140 PF13600.6 EMC90266.1 - 6.1 7.4 8.2 2.6 8.5 1.2 2.6 2 1 1 3 3 2 0 N-terminal domain of unknown function (DUF4140) MYT1 PF08474.11 EMC90267.1 - 4e-110 367.5 8.5 4e-110 367.5 8.5 4.3 3 1 0 3 3 3 1 Myelin transcription factor 1 zf-C2HC PF01530.18 EMC90267.1 - 3.2e-81 267.1 85.3 1e-15 57.6 7.2 7.7 7 0 0 7 7 7 6 Zinc finger, C2HC type zf-RAG1 PF10426.9 EMC90267.1 - 0.43 10.8 0.1 0.43 10.8 0.1 6.3 7 0 0 7 7 7 0 Recombination-activating protein 1 zinc-finger domain Anti-TRAP PF15777.5 EMC90267.1 - 2.3 8.3 27.0 0.82 9.7 0.2 6.5 6 0 0 6 6 6 0 Tryptophan RNA-binding attenuator protein inhibitory protein WD40 PF00400.32 EMC90268.1 - 3.1e-17 62.6 5.8 1.4e-05 25.7 0.0 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat TPR_2 PF07719.17 EMC90269.1 - 2.1e-12 46.1 0.0 0.0071 16.4 0.0 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMC90269.1 - 6.5e-12 44.7 0.1 0.0014 18.3 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EMC90269.1 - 3.6e-08 33.6 0.2 0.00075 19.7 0.0 3.2 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 EMC90269.1 - 2.2e-06 28.0 0.0 0.019 15.4 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMC90269.1 - 6.8e-06 26.6 0.0 0.013 16.2 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 EMC90269.1 - 2.3e-05 24.8 0.1 0.0027 18.3 0.0 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EMC90269.1 - 0.0017 18.4 0.0 4.7 7.7 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 EMC90269.1 - 0.0024 18.1 0.6 2.8 8.5 0.1 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat Coatomer_E PF04733.14 EMC90269.1 - 0.0071 15.8 0.2 0.019 14.4 0.1 1.7 2 0 0 2 2 2 1 Coatomer epsilon subunit TPR_14 PF13428.6 EMC90269.1 - 0.053 14.4 0.0 37 5.5 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC90269.1 - 0.062 13.5 1.2 1.2 9.5 0.1 2.7 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 HrpB1_HrpK PF09613.10 EMC90269.1 - 0.064 12.9 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB1_HrpK) RNase_H PF00075.24 EMC90270.1 - 1.4e-46 158.2 0.0 2.3e-46 157.5 0.0 1.3 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.16 EMC90270.1 - 6.5e-05 23.1 0.9 0.00015 22.0 0.9 1.7 1 0 0 1 1 1 1 Caulimovirus viroplasmin RVT_3 PF13456.6 EMC90270.1 - 0.00044 20.0 0.0 0.001 18.8 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase-like MafB19-deam PF14437.6 EMC90270.1 - 0.065 13.0 0.0 0.095 12.4 0.0 1.3 1 0 0 1 1 1 0 MafB19-like deaminase Ribosomal_S7e PF01251.18 EMC90271.1 - 4.5e-94 313.4 4.1 5.1e-94 313.2 4.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e Lectin_C PF00059.21 EMC90272.1 - 1.5e-17 64.3 0.0 2.3e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.18 EMC90272.1 - 2.9e-15 55.7 52.5 3.2e-09 36.4 24.8 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Thymidylate_kin PF02223.17 EMC90273.1 - 5.6e-21 75.1 0.0 1.6e-20 73.5 0.0 1.7 1 1 0 1 1 1 1 Thymidylate kinase AAA_33 PF13671.6 EMC90273.1 - 1.5e-06 28.4 0.0 3.6e-06 27.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMC90273.1 - 4.1e-06 27.4 0.0 1.3e-05 25.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain dNK PF01712.19 EMC90273.1 - 0.00022 21.2 0.0 0.00035 20.5 0.0 1.4 1 1 0 1 1 1 1 Deoxynucleoside kinase AAA_17 PF13207.6 EMC90273.1 - 0.0081 16.6 0.2 0.17 12.3 0.0 2.8 2 1 1 3 3 3 1 AAA domain AAA_28 PF13521.6 EMC90273.1 - 0.011 15.9 0.2 0.023 15.0 0.2 1.5 1 1 0 1 1 1 0 AAA domain PPK2 PF03976.14 EMC90273.1 - 0.013 15.0 0.0 0.09 12.3 0.0 1.9 2 0 0 2 2 2 0 Polyphosphate kinase 2 (PPK2) AAA_16 PF13191.6 EMC90273.1 - 0.024 15.0 0.1 0.046 14.1 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain 6PF2K PF01591.18 EMC90273.1 - 0.15 11.4 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase IBR PF01485.21 EMC90274.1 - 4.2e-20 71.7 27.1 4.5e-13 49.2 12.0 4.6 4 1 1 5 5 5 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 EMC90274.1 - 0.022 15.1 7.0 0.022 15.1 7.0 4.9 4 2 1 5 5 5 0 Ring finger domain HLH PF00010.26 EMC90275.1 - 4.5e-14 52.2 0.4 7.2e-14 51.5 0.4 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain KAP_NTPase PF07693.14 EMC90276.1 - 2.1e-108 362.5 0.1 2.9e-108 362.0 0.1 1.2 1 0 0 1 1 1 1 KAP family P-loop domain Ank_2 PF12796.7 EMC90276.1 - 2.2e-76 252.5 1.4 1.5e-13 51.2 0.0 6.8 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC90276.1 - 2.6e-62 206.0 7.0 4.2e-12 46.0 0.2 10.3 2 1 8 10 10 10 10 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMC90276.1 - 3.5e-61 202.8 3.1 3.3e-10 40.3 0.0 9.7 3 2 8 11 11 11 10 Ankyrin repeats (many copies) Ank PF00023.30 EMC90276.1 - 2.4e-56 185.8 0.8 7.1e-07 29.4 0.0 11.8 11 0 0 11 11 11 10 Ankyrin repeat Ank_3 PF13606.6 EMC90276.1 - 1.4e-49 160.2 0.4 6.4e-06 26.1 0.0 12.5 12 0 0 12 12 12 10 Ankyrin repeat SAM_1 PF00536.30 EMC90276.1 - 0.001 19.5 0.0 0.0045 17.4 0.0 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) NACHT PF05729.12 EMC90276.1 - 0.0027 17.6 0.1 0.35 10.8 0.0 3.0 3 0 0 3 3 3 1 NACHT domain DUF4988 PF16378.5 EMC90276.1 - 0.069 12.8 0.2 0.55 9.9 0.1 2.5 2 1 0 3 3 3 0 Domain of unknown function MgtE PF01769.16 EMC90276.1 - 0.62 10.4 7.9 3.1 8.2 1.9 2.3 2 0 0 2 2 2 0 Divalent cation transporter MBOAT PF03062.19 EMC90277.1 - 7.3e-30 104.5 20.8 2e-28 99.8 20.8 2.4 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family ArfGap PF01412.18 EMC90278.1 - 3.7e-33 114.1 0.6 9.5e-33 112.8 0.0 2.0 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 EMC90278.1 - 1.1e-24 87.5 5.7 2.2e-24 86.5 5.7 1.5 1 0 0 1 1 1 1 BAR domain of APPL family Ank_2 PF12796.7 EMC90278.1 - 5.6e-19 68.5 4.8 4.5e-10 40.0 0.5 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) PH PF00169.29 EMC90278.1 - 3.7e-12 46.7 0.6 1.4e-11 44.8 0.4 2.2 2 0 0 2 2 1 1 PH domain SH3_9 PF14604.6 EMC90278.1 - 8.7e-10 38.3 0.1 1.7e-09 37.4 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ank_4 PF13637.6 EMC90278.1 - 4.1e-09 36.8 1.3 4.3e-05 24.0 0.2 3.2 2 1 2 4 4 3 2 Ankyrin repeats (many copies) SH3_1 PF00018.28 EMC90278.1 - 7.1e-09 35.1 1.3 1.6e-08 34.0 0.2 2.2 2 0 0 2 2 2 1 SH3 domain Ank PF00023.30 EMC90278.1 - 1.9e-08 34.4 0.7 0.0012 19.1 0.1 3.6 3 0 0 3 3 3 2 Ankyrin repeat SH3_2 PF07653.17 EMC90278.1 - 1.6e-07 30.9 0.1 3.8e-07 29.7 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain Ank_3 PF13606.6 EMC90278.1 - 1.3e-06 28.3 0.5 0.1 13.2 0.0 3.9 4 0 0 4 4 3 2 Ankyrin repeat BAR PF03114.18 EMC90278.1 - 3.6e-06 26.8 1.6 6.2e-06 26.0 1.6 1.4 1 0 0 1 1 1 1 BAR domain Ank_5 PF13857.6 EMC90278.1 - 6.5e-06 26.3 0.1 0.00011 22.4 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) PH_9 PF15410.6 EMC90278.1 - 0.0068 16.8 0.2 1.7 9.0 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain PH_13 PF16652.5 EMC90278.1 - 0.032 14.0 0.0 0.084 12.7 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain ICAP-1_inte_bdg PF10480.9 EMC90279.1 - 4.3e-127 421.9 8.9 4.8e-127 421.8 8.9 1.0 1 0 0 1 1 1 1 Beta-1 integrin binding protein PID PF00640.23 EMC90279.1 - 1.5e-06 28.3 0.0 2.5e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) YCII PF03795.14 EMC90279.1 - 0.058 13.8 0.0 0.11 13.0 0.0 1.6 1 1 0 1 1 1 0 YCII-related domain DUF4015 PF13200.6 EMC90279.1 - 0.063 12.3 0.0 0.086 11.9 0.0 1.2 1 0 0 1 1 1 0 Putative glycosyl hydrolase domain Herpes_UL6 PF01763.16 EMC90279.1 - 0.34 9.4 3.4 2.8 6.4 1.2 2.0 2 0 0 2 2 2 0 Herpesvirus UL6 like AdoMetDC_leader PF08132.11 EMC90279.1 - 3.8 7.5 9.0 25 4.9 4.9 3.1 2 1 0 2 2 2 0 S-adenosyl-l-methionine decarboxylase leader peptide CPSF73-100_C PF11718.8 EMC90280.1 - 9.7e-56 188.7 0.2 1.8e-55 187.9 0.2 1.4 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 EMC90280.1 - 9.1e-34 116.1 0.0 2.1e-33 114.9 0.0 1.7 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 EMC90280.1 - 6.7e-22 77.2 0.2 1.4e-21 76.2 0.2 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_6 PF16661.5 EMC90280.1 - 4.1e-18 65.5 0.0 1e-17 64.2 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 EMC90280.1 - 1.1e-17 64.7 0.1 1.9e-17 63.9 0.1 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EMC90280.1 - 3.1e-08 33.4 0.3 2.6e-07 30.4 0.0 2.2 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EMC90280.1 - 2e-06 27.8 0.3 7.6e-05 22.7 0.0 3.3 2 1 1 3 3 3 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 EMC90280.1 - 0.0009 18.5 0.1 0.0024 17.2 0.1 1.7 1 0 0 1 1 1 1 Putative beta-lactamase-like family DUF1611 PF07755.11 EMC90280.1 - 0.022 14.0 0.0 0.048 12.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1611_C) P-loop domain Lipase_GDSL_2 PF13472.6 EMC90281.1 - 7.4e-22 78.6 0.0 1.1e-21 78.0 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EMC90281.1 - 1.3e-17 64.5 0.0 1.5e-17 64.3 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Retrotrans_gag PF03732.17 EMC90281.1 - 0.034 14.4 0.0 1.7 9.0 0.0 2.6 2 1 0 2 2 2 0 Retrotransposon gag protein 14-3-3 PF00244.20 EMC90282.1 - 4.1e-107 356.7 5.2 4.7e-107 356.6 5.2 1.0 1 0 0 1 1 1 1 14-3-3 protein FliM PF02154.15 EMC90282.1 - 0.095 12.6 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 Flagellar motor switch protein FliM Peptidase_C98 PF15499.6 EMC90282.1 - 0.11 11.9 0.1 0.17 11.3 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase XhlA PF10779.9 EMC90282.1 - 3.1 8.1 4.8 0.8 10.0 1.0 1.9 2 0 0 2 2 2 0 Haemolysin XhlA zf-RRN7 PF11781.8 EMC90283.1 - 1.1e-09 37.8 5.1 1.1e-09 37.8 5.1 2.6 2 0 0 2 2 2 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 CP2 PF04516.15 EMC90284.1 - 4e-81 271.7 2.1 6.1e-81 271.1 2.1 1.2 1 0 0 1 1 1 1 CP2 transcription factor EF-hand_7 PF13499.6 EMC90285.1 - 3.4e-28 97.9 3.5 2.7e-17 63.0 0.1 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EMC90285.1 - 5.7e-27 91.2 5.4 3.2e-07 29.4 0.3 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EMC90285.1 - 2.2e-23 80.1 3.7 5.5e-07 29.0 0.1 4.4 4 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EMC90285.1 - 1.2e-21 75.2 6.3 3.3e-07 29.5 0.3 4.5 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 EMC90285.1 - 8.5e-20 70.4 6.3 3.1e-08 33.4 0.1 3.7 3 2 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EMC90285.1 - 4.4e-07 30.2 0.1 0.0071 16.6 0.0 3.3 2 2 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EMC90285.1 - 4.8e-06 26.5 0.7 0.18 11.8 0.0 3.4 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 EMC90285.1 - 0.0025 17.6 0.4 4.1 7.3 0.1 3.0 3 0 0 3 3 3 2 EF hand Dockerin_1 PF00404.18 EMC90285.1 - 0.0032 17.6 0.0 1.4 9.1 0.0 2.5 2 1 0 2 2 2 2 Dockerin type I domain Orn_Arg_deC_N PF02784.16 EMC90286.1 - 8.5e-92 307.0 0.0 1.2e-91 306.5 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EMC90286.1 - 2.3e-20 72.6 0.0 3.3e-20 72.1 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain NUC153 PF08159.12 EMC90287.1 - 1.3e-12 47.2 0.9 3.2e-12 46.0 0.9 1.7 1 0 0 1 1 1 1 NUC153 domain Thioredoxin PF00085.20 EMC90288.1 - 3.4e-66 219.7 0.0 1.1e-31 108.9 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 EMC90288.1 - 2.6e-11 43.9 0.6 0.00099 19.5 0.0 3.6 2 2 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_6 PF13848.6 EMC90288.1 - 1.1e-07 32.0 0.0 0.00067 19.6 0.0 3.1 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 EMC90288.1 - 1.8e-07 31.2 0.0 0.004 17.3 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.6 EMC90288.1 - 1.6e-06 28.3 0.0 0.11 12.8 0.0 3.7 3 2 2 5 5 4 2 Thioredoxin-like OST3_OST6 PF04756.13 EMC90288.1 - 2.7e-06 26.9 0.0 0.0027 17.1 0.0 2.3 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_3 PF13192.6 EMC90288.1 - 0.00012 22.1 0.0 0.26 11.4 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin domain AhpC-TSA PF00578.21 EMC90288.1 - 0.0013 18.6 0.0 2.1 8.3 0.0 2.4 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_9 PF14595.6 EMC90288.1 - 0.028 14.2 0.0 0.45 10.3 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin Thioredoxin_4 PF13462.6 EMC90288.1 - 0.049 13.8 0.6 1.7 8.8 0.1 2.8 2 2 1 3 3 3 0 Thioredoxin Calsequestrin PF01216.17 EMC90288.1 - 0.068 12.2 0.0 0.83 8.6 0.0 2.3 2 0 0 2 2 2 0 Calsequestrin HyaE PF07449.11 EMC90288.1 - 0.084 12.8 0.0 7.1 6.6 0.0 2.3 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE DUF3228 PF11539.8 EMC90288.1 - 0.1 12.1 0.0 12 5.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3228) DUF945 PF06097.11 EMC90289.1 - 0.043 12.9 0.0 0.91 8.6 0.0 2.3 1 1 1 3 3 3 0 Bacterial protein of unknown function (DUF945) DNA_pol3_alpha PF07733.12 EMC90289.1 - 0.061 12.9 0.2 9.7 5.7 0.0 2.9 3 0 0 3 3 3 0 Bacterial DNA polymerase III alpha NTPase domain Ion_trans PF00520.31 EMC90290.1 - 2.5e-46 157.9 7.3 3.6e-46 157.4 7.3 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 EMC90290.1 - 1.2e-19 70.4 0.0 3.5e-19 68.9 0.0 1.9 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 EMC90290.1 - 1.4e-12 47.4 2.2 1.4e-12 47.4 2.2 1.9 2 0 0 2 2 2 1 Ion channel PKD_channel PF08016.12 EMC90290.1 - 0.00025 19.8 1.0 0.00025 19.8 1.0 1.5 1 1 1 2 2 2 1 Polycystin cation channel LLC1 PF14945.6 EMC90291.1 - 2.3e-07 31.4 4.0 4e-06 27.4 4.0 2.0 1 1 0 1 1 1 1 Normal lung function maintenance, Low in Lung Cancer 1 protein Exonuc_V_gamma PF04257.14 EMC90291.1 - 0.16 10.1 2.1 0.17 10.0 2.1 1.0 1 0 0 1 1 1 0 Exodeoxyribonuclease V, gamma subunit Torus PF16131.5 EMC90291.1 - 0.26 12.0 1.7 0.27 11.9 1.7 1.2 1 0 0 1 1 1 0 Torus domain Pkinase PF00069.25 EMC90293.1 - 4.9e-62 209.7 0.0 4.9e-62 209.7 0.0 3.2 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC90293.1 - 5.2e-30 104.6 0.9 2.3e-29 102.5 0.0 2.6 2 0 0 2 2 2 1 Protein tyrosine kinase Rho_Binding PF08912.11 EMC90293.1 - 1.1e-25 90.2 14.2 1.1e-25 90.2 14.2 12.7 8 3 5 13 13 13 1 Rho Binding PH PF00169.29 EMC90293.1 - 2.8e-05 24.6 0.1 0.00012 22.6 0.1 2.1 1 0 0 1 1 1 1 PH domain C1_1 PF00130.22 EMC90293.1 - 8.6e-05 22.3 6.4 0.00019 21.2 6.4 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) APH PF01636.23 EMC90293.1 - 0.0056 16.6 3.4 0.011 15.7 0.4 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pkinase_C PF00433.24 EMC90293.1 - 7.8 7.3 6.2 4 8.2 3.2 2.3 2 1 0 2 2 2 0 Protein kinase C terminal domain E2F_CC-MB PF16421.5 EMC90294.1 - 4.4e-32 110.3 0.9 7.1e-32 109.6 0.9 1.3 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.20 EMC90294.1 - 1.1e-22 79.8 0.2 2.5e-22 78.7 0.0 1.7 2 0 0 2 2 2 1 E2F/DP family winged-helix DNA-binding domain TMEM215 PF15746.5 EMC90294.1 - 0.013 14.9 0.3 0.016 14.7 0.3 1.1 1 0 0 1 1 1 0 TMEM215 family Med4 PF10018.9 EMC90294.1 - 0.057 13.1 0.2 0.077 12.7 0.2 1.2 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 HrpB7 PF09486.10 EMC90294.1 - 0.06 13.7 0.0 0.087 13.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) TrmB PF01978.19 EMC90294.1 - 0.075 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB FerA PF08165.11 EMC90294.1 - 0.098 12.6 0.4 0.41 10.6 0.3 2.0 2 0 0 2 2 2 0 FerA (NUC095) domain Pkinase PF00069.25 EMC90295.1 - 1.6e-35 122.8 0.0 2.2e-35 122.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC90295.1 - 1.1e-18 67.5 0.0 1.5e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC90295.1 - 1.4e-05 24.6 0.0 2e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like LRAT PF04970.13 EMC90296.1 - 9.1e-10 38.9 0.1 9.5e-05 22.7 0.0 2.5 1 1 1 2 2 2 2 Lecithin retinol acyltransferase NLPC_P60 PF00877.19 EMC90296.1 - 0.0036 17.3 0.0 0.013 15.5 0.0 1.9 1 1 0 1 1 1 1 NlpC/P60 family Nbas_N PF15492.6 EMC90297.1 - 7.3e-174 576.7 0.2 1.2e-173 576.0 0.2 1.4 1 0 0 1 1 1 1 Neuroblastoma-amplified sequence, N terminal Sec39 PF08314.11 EMC90297.1 - 1.3e-27 96.6 11.6 2.8e-26 92.3 6.8 2.8 2 1 0 2 2 2 1 Secretory pathway protein Sec39 ANAPC4_WD40 PF12894.7 EMC90297.1 - 0.018 15.3 0.0 5.6 7.3 0.0 3.6 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain DUF2508 PF10704.9 EMC90297.1 - 0.088 13.0 0.3 6.6 7.0 0.0 3.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) GP67 PF17634.2 EMC90297.1 - 0.22 12.0 3.2 0.56 10.7 3.2 1.6 1 0 0 1 1 1 0 Gene product 67 WD40 PF00400.32 EMC90297.1 - 0.39 11.7 3.4 9.5 7.3 0.3 4.2 4 0 0 4 4 4 0 WD domain, G-beta repeat DEAD PF00270.29 EMC90298.1 - 2.2e-77 258.8 0.0 3.6e-77 258.1 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMC90298.1 - 1.2e-27 96.5 0.1 5.5e-27 94.3 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SPRY PF00622.28 EMC90298.1 - 1.6e-23 83.1 0.9 2.6e-23 82.4 0.2 1.8 2 0 0 2 2 2 1 SPRY domain CMS1 PF14617.6 EMC90298.1 - 0.0025 17.2 0.1 0.011 15.1 0.0 1.9 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.15 EMC90298.1 - 0.0058 16.6 0.0 0.18 11.8 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF1394 PF07159.12 EMC90299.1 - 2.2e-148 493.4 1.9 2.5e-148 493.3 1.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) EF-hand_7 PF13499.6 EMC90300.1 - 2.3e-25 88.8 4.5 2.7e-16 59.7 0.7 3.1 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EMC90300.1 - 5.6e-25 85.0 12.9 9.6e-08 31.1 0.1 4.6 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 EMC90300.1 - 9.9e-23 78.1 5.5 2.9e-07 29.9 0.1 4.7 4 1 1 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 EMC90300.1 - 2.3e-17 61.6 9.4 6.1e-06 25.5 0.3 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EMC90300.1 - 2.8e-13 49.5 11.5 3e-05 23.8 0.4 4.3 4 1 0 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EMC90300.1 - 1.5e-05 25.3 2.0 0.061 13.6 0.5 3.3 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 EMC90300.1 - 0.00025 21.2 0.1 0.069 13.4 0.0 2.8 3 0 0 3 3 3 1 Dockerin type I domain p25-alpha PF05517.12 EMC90300.1 - 0.0014 18.8 1.2 0.051 13.7 0.4 2.4 2 0 0 2 2 2 1 p25-alpha Caleosin PF05042.13 EMC90300.1 - 0.0023 17.9 6.2 0.1 12.5 3.3 3.3 2 1 0 2 2 2 1 Caleosin related protein EF-hand_9 PF14658.6 EMC90300.1 - 0.0034 17.7 0.1 5.6 7.4 0.0 3.2 3 0 0 3 3 3 1 EF-hand domain IL3 PF02059.15 EMC90300.1 - 0.0041 17.2 0.1 0.016 15.2 0.0 1.9 2 0 0 2 2 2 1 Interleukin-3 EF-hand_4 PF12763.7 EMC90300.1 - 0.034 14.1 7.1 9.8 6.2 0.0 3.9 2 1 2 4 4 4 0 Cytoskeletal-regulatory complex EF hand SMC_N PF02463.19 EMC90301.1 - 1.4e-18 67.2 19.8 4e-18 65.7 19.8 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EMC90301.1 - 3.2e-13 50.6 20.7 3.2e-13 50.6 20.7 6.0 3 2 0 3 3 2 1 AAA domain AAA_15 PF13175.6 EMC90301.1 - 7.1e-09 35.8 9.6 7.1e-09 35.8 9.6 3.7 2 2 1 3 3 2 1 AAA ATPase domain AAA_21 PF13304.6 EMC90301.1 - 0.00021 21.2 11.4 0.0048 16.7 0.3 3.7 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system WEMBL PF05701.11 EMC90301.1 - 0.0023 16.7 28.6 0.0023 16.7 28.6 3.9 2 2 1 3 3 2 1 Weak chloroplast movement under blue light Snapin_Pallidin PF14712.6 EMC90301.1 - 0.0035 17.7 9.3 0.0035 17.7 9.3 8.1 4 2 4 9 9 9 2 Snapin/Pallidin AAA_29 PF13555.6 EMC90301.1 - 0.0094 15.7 0.3 0.018 14.8 0.3 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF1474 PF07342.11 EMC90301.1 - 0.029 14.9 0.8 0.029 14.9 0.8 2.9 2 1 0 2 2 1 0 Protein of unknown function (DUF1474) Spc7 PF08317.11 EMC90301.1 - 0.036 13.0 101.2 0.23 10.3 18.6 5.6 2 2 2 4 4 4 0 Spc7 kinetochore protein DUF4023 PF13215.6 EMC90301.1 - 0.08 13.0 1.6 0.31 11.1 1.6 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4023) Pox_A_type_inc PF04508.12 EMC90301.1 - 2.7 8.0 13.2 6.8 6.7 0.5 4.7 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat NPV_P10 PF05531.12 EMC90301.1 - 3.1 8.3 24.8 2.2 8.8 3.9 6.3 4 2 3 7 7 7 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 EMC90301.1 - 5.1 7.1 60.3 1.3 9.0 4.0 7.2 2 2 5 8 8 8 0 Protein of unknown function (DUF1664) FtsK_SpoIIIE PF01580.18 EMC90301.1 - 9.6 5.5 11.0 0.15 11.4 0.1 3.0 3 1 0 3 3 3 0 FtsK/SpoIIIE family XPG_I PF00867.18 EMC90302.1 - 1.5e-25 89.3 2.6 1.6e-25 89.3 0.1 2.4 3 0 0 3 3 3 1 XPG I-region Chromo_2 PF18704.1 EMC90302.1 - 4.5e-22 78.1 0.4 1.2e-21 76.7 0.4 1.8 1 0 0 1 1 1 1 Chromatin organization modifier domain 2 HLH PF00010.26 EMC90304.1 - 3.5e-11 42.9 2.1 4.6e-11 42.5 1.4 1.5 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Zona_pellucida PF00100.23 EMC90305.1 - 1.9e-39 136.0 4.5 2e-38 132.6 0.5 2.8 2 1 0 2 2 2 2 Zona pellucida-like domain 5-nucleotidase PF06189.12 EMC90306.1 - 1.9e-98 328.6 0.0 2.1e-98 328.5 0.0 1.0 1 0 0 1 1 1 1 5'-nucleotidase zf-C2H2 PF00096.26 EMC90307.1 - 2.1e-13 49.9 25.4 0.00012 22.4 4.5 3.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC90307.1 - 5.3e-12 45.6 26.0 3.1e-06 27.3 0.8 4.2 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC90307.1 - 1e-08 35.3 22.6 0.0069 17.1 2.6 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC90307.1 - 1.3e-05 25.0 21.6 0.00012 22.0 1.8 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC90307.1 - 0.0012 19.1 14.2 0.16 12.3 1.3 3.3 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 EMC90307.1 - 0.0013 18.8 7.7 0.016 15.3 1.7 2.4 2 0 0 2 2 2 2 Zinc ribbon domain C1_4 PF07975.12 EMC90307.1 - 0.0013 18.9 10.9 0.23 11.7 5.9 2.8 1 1 2 3 3 3 2 TFIIH C1-like domain XPA_N PF01286.18 EMC90307.1 - 0.0074 16.3 7.9 0.28 11.3 0.8 3.3 3 0 0 3 3 3 1 XPA protein N-terminal zf-AN1 PF01428.16 EMC90307.1 - 0.017 15.3 16.9 0.16 12.2 3.3 3.4 2 1 1 3 3 3 0 AN1-like Zinc finger GAGA PF09237.11 EMC90307.1 - 0.029 14.2 2.6 0.1 12.4 0.3 2.4 1 1 1 2 2 2 0 GAGA factor zf-met PF12874.7 EMC90307.1 - 0.12 12.8 0.4 0.12 12.8 0.4 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type CpXC PF14353.6 EMC90307.1 - 0.17 11.9 7.1 0.3 11.2 0.1 2.7 1 1 2 3 3 3 0 CpXC protein zf_UBZ PF18439.1 EMC90307.1 - 0.55 9.9 8.0 14 5.4 0.1 3.3 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger FYVE PF01363.21 EMC90307.1 - 0.76 10.0 13.7 0.42 10.8 6.6 2.3 1 1 1 2 2 2 0 FYVE zinc finger LIM PF00412.22 EMC90307.1 - 1.6 9.0 12.2 28 5.1 6.7 2.7 1 1 1 2 2 2 0 LIM domain zf-Di19 PF05605.12 EMC90307.1 - 6.7 7.1 10.9 0.36 11.2 4.0 2.1 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-trcl PF13451.6 EMC90307.1 - 8.2 6.4 13.0 5.8 6.9 0.4 3.1 3 0 0 3 3 3 0 Probable zinc-ribbon domain Zona_pellucida PF00100.23 EMC90308.1 - 6.5e-28 98.2 3.2 9.1e-26 91.2 0.2 2.4 2 0 0 2 2 2 2 Zona pellucida-like domain Arrestin_N PF00339.29 EMC90308.1 - 0.14 12.2 0.9 0.38 10.8 0.0 2.2 3 0 0 3 3 3 0 Arrestin (or S-antigen), N-terminal domain TPR_1 PF00515.28 EMC90309.1 - 4e-10 39.1 2.0 0.00035 20.3 0.0 3.5 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 EMC90309.1 - 4.8e-10 39.0 0.1 2.4e-05 23.9 0.1 2.4 2 1 0 2 2 2 2 TPR repeat TPR_2 PF07719.17 EMC90309.1 - 1.2e-07 31.3 2.7 0.0069 16.4 0.0 3.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EMC90309.1 - 0.00014 21.8 1.7 0.04 14.1 0.0 3.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 EMC90309.1 - 0.00036 20.7 0.0 0.019 15.3 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 EMC90309.1 - 0.0016 18.6 1.3 1.2 9.3 0.2 2.6 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMC90309.1 - 0.0083 16.6 0.2 0.14 12.7 0.1 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EMC90309.1 - 0.0096 16.7 0.8 0.27 12.1 0.1 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 EMC90309.1 - 0.012 15.0 2.9 1.2 8.6 0.0 3.0 2 1 1 3 3 3 0 SHNi-TPR Fis1_TPR_C PF14853.6 EMC90309.1 - 0.048 13.7 0.2 0.2 11.7 0.1 1.9 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_16 PF13432.6 EMC90309.1 - 0.21 12.2 1.9 19 6.0 0.0 3.0 1 1 1 2 2 2 0 Tetratricopeptide repeat ANAPC4_WD40 PF12894.7 EMC90310.1 - 6.8e-15 55.2 10.6 9.6e-06 25.8 0.1 7.2 4 2 5 9 9 9 5 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 EMC90310.1 - 4.1e-05 22.8 5.7 0.0015 17.7 0.1 4.1 4 0 0 4 4 4 1 Coatomer WD associated region Clathrin PF00637.20 EMC90310.1 - 4.6e-05 23.3 4.1 9.7e-05 22.3 1.6 2.5 1 1 1 2 2 2 1 Region in Clathrin and VPS RPN1_RPN2_N PF17781.1 EMC90310.1 - 0.0017 17.8 1.4 0.0034 16.8 1.4 1.5 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain WD40 PF00400.32 EMC90310.1 - 0.0093 16.8 17.3 0.24 12.3 0.0 6.4 7 1 1 8 8 8 2 WD domain, G-beta repeat DUF410 PF04190.13 EMC90310.1 - 0.018 14.9 4.3 0.73 9.6 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF410) eIF2A PF08662.11 EMC90310.1 - 0.044 13.6 2.0 0.41 10.5 0.4 3.1 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A Prok-RING_4 PF14447.6 EMC90310.1 - 0.089 12.7 4.0 0.24 11.3 4.0 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 TPR_16 PF13432.6 EMC90310.1 - 0.5 11.1 7.6 3.5 8.4 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Cmc1 PF08583.10 EMC90310.1 - 1.4 9.0 6.7 0.26 11.4 0.9 2.8 3 0 0 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like VWA PF00092.28 EMC90311.1 - 6.5e-48 163.3 0.2 7.8e-48 163.0 0.2 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain FXa_inhibition PF14670.6 EMC90311.1 - 1.2e-29 102.3 62.6 1.1e-07 31.9 10.0 4.3 4 0 0 4 4 4 4 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 EMC90311.1 - 8e-21 74.0 49.9 2.3e-06 27.7 6.4 4.2 4 0 0 4 4 4 4 Calcium-binding EGF domain VWA_2 PF13519.6 EMC90311.1 - 1.9e-19 70.3 0.1 2.7e-19 69.8 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain cEGF PF12662.7 EMC90311.1 - 2e-19 69.2 33.5 2.8e-05 23.9 2.4 4.7 4 0 0 4 4 4 4 Complement Clr-like EGF-like VWA_3 PF13768.6 EMC90311.1 - 3e-05 24.0 0.1 4.5e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain EGF PF00008.27 EMC90311.1 - 0.00015 22.0 51.3 0.079 13.3 6.6 4.6 4 0 0 4 4 4 3 EGF-like domain Plasmod_Pvs28 PF06247.11 EMC90311.1 - 0.011 16.0 40.7 0.07 13.4 2.6 4.5 4 0 0 4 4 4 0 Pvs28 EGF domain zf-NF-X1 PF01422.17 EMC90311.1 - 0.013 15.5 24.1 2.9 8.0 1.6 4.9 4 0 0 4 4 4 0 NF-X1 type zinc finger EGF_3 PF12947.7 EMC90311.1 - 0.61 10.3 43.5 0.98 9.7 4.7 4.8 4 0 0 4 4 4 0 EGF domain Mtp PF03821.16 EMC90312.1 - 1.8e-23 83.4 13.5 4.4e-16 59.2 4.4 2.1 1 1 1 2 2 2 2 Golgi 4-transmembrane spanning transporter DUF4728 PF15860.5 EMC90312.1 - 0.00021 21.9 4.1 0.00021 21.9 4.1 2.5 2 1 1 3 3 3 2 Domain of unknown function (DUF4728) MG3 PF17791.1 EMC90312.1 - 0.041 14.2 1.6 1.6 9.0 0.2 2.4 2 0 0 2 2 2 0 Macroglobulin domain MG3 Ig_2 PF13895.6 EMC90313.1 - 8.9e-06 26.0 0.0 1.5e-05 25.2 0.0 1.4 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC90313.1 - 0.00052 20.6 0.0 0.0008 20.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Asp PF00026.23 EMC90314.1 - 1.9e-38 132.7 0.1 4.3e-38 131.5 0.1 1.5 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 EMC90314.1 - 1.4e-12 47.7 0.0 2e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal TAXi_N PF14543.6 EMC90314.1 - 0.0028 17.9 0.1 0.014 15.6 0.1 2.0 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Trypsin PF00089.26 EMC90315.1 - 1.5e-70 237.4 1.3 2.1e-70 237.0 1.3 1.2 1 0 0 1 1 1 1 Trypsin SRCR_2 PF15494.6 EMC90315.1 - 6e-31 106.9 0.6 1.4e-30 105.7 0.6 1.7 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain DUF1986 PF09342.11 EMC90315.1 - 2e-08 34.6 0.0 5.9e-08 33.1 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Hepsin-SRCR PF09272.10 EMC90315.1 - 2.5e-08 34.4 0.2 5.2e-08 33.4 0.2 1.4 1 0 0 1 1 1 1 Hepsin, SRCR domain Ldl_recept_a PF00057.18 EMC90315.1 - 0.0001 22.4 6.2 0.00032 20.9 6.2 1.9 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A SRCR PF00530.18 EMC90315.1 - 0.00014 22.3 0.1 0.00045 20.7 0.1 1.9 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Trypsin_2 PF13365.6 EMC90315.1 - 0.0002 22.3 0.0 0.00034 21.5 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF3139 PF11337.8 EMC90315.1 - 0.52 11.0 2.3 1.2 9.8 2.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) zf-C2H2 PF00096.26 EMC90316.1 - 2.3e-48 160.0 137.5 7.5e-06 26.1 1.1 17.8 18 0 0 18 18 17 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC90316.1 - 1.4e-44 146.9 126.5 0.00054 20.6 0.5 17.7 18 0 0 18 18 17 16 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC90316.1 - 1.1e-30 104.7 110.8 1.4e-05 25.3 0.5 17.6 18 0 0 18 18 17 10 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EMC90316.1 - 1.3e-21 76.4 92.6 0.0063 16.8 0.8 17.8 17 1 1 18 18 18 9 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC90316.1 - 3.2e-17 62.3 99.7 0.012 16.0 0.2 16.7 17 0 0 17 17 17 11 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EMC90316.1 - 2.8e-07 30.4 103.5 0.27 11.3 0.0 16.8 17 0 0 17 17 17 7 C2H2-type zinc finger zf-C2HC_2 PF13913.6 EMC90316.1 - 0.00088 19.1 51.6 0.021 14.7 0.2 10.8 12 0 0 12 12 11 4 zinc-finger of a C2HC-type SET PF00856.28 EMC90316.1 - 0.0012 19.3 0.1 0.0078 16.6 0.0 2.5 3 0 0 3 3 3 1 SET domain zf-MYST PF17772.1 EMC90316.1 - 0.015 14.9 0.9 0.015 14.9 0.9 9.7 10 2 2 12 12 12 0 MYST family zinc finger domain zinc_ribbon_15 PF17032.5 EMC90316.1 - 0.057 14.2 67.0 2 9.3 0.8 9.2 6 2 2 9 9 9 0 zinc-ribbon family BolA PF01722.18 EMC90316.1 - 0.88 9.9 12.7 49 4.3 0.2 6.5 5 2 2 7 7 7 0 BolA-like protein zf-C2H2_3rep PF18868.1 EMC90316.1 - 4.4 8.0 56.4 1.9 9.1 1.4 8.7 3 1 3 7 7 6 0 Zinc finger C2H2-type, 3 repeats GAGA PF09237.11 EMC90316.1 - 6 6.8 14.1 6.5 6.6 0.2 5.2 5 1 0 5 5 5 0 GAGA factor SMP_C2CD2L PF18696.1 EMC90318.1 - 1.7e-45 154.6 2.5 1.7e-45 154.6 2.5 2.0 2 0 0 2 2 2 1 Synaptotagmin-like, mitochondrial and lipid-binding domain C2 PF00168.30 EMC90318.1 - 5.6e-08 33.0 0.0 3.2e-07 30.6 0.0 2.4 2 0 0 2 2 2 1 C2 domain DOCK-C2 PF14429.6 EMC90318.1 - 0.013 15.3 0.4 0.033 14.0 0.0 1.8 2 0 0 2 2 2 0 C2 domain in Dock180 and Zizimin proteins CEP76-C2 PF15627.6 EMC90318.1 - 0.059 12.9 0.0 0.16 11.6 0.0 1.7 1 0 0 1 1 1 0 CEP76 C2 domain BTB PF00651.31 EMC90319.1 - 7.2e-26 90.6 0.1 1.3e-25 89.7 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf_C2H2_6 PF18450.1 EMC90319.1 - 1.9e-15 56.2 4.9 1.9e-15 56.2 4.9 3.6 3 0 0 3 3 3 1 Zinc Finger domain zf-C2H2 PF00096.26 EMC90319.1 - 2.9e-15 55.7 69.7 0.00088 19.6 1.7 9.3 9 0 0 9 9 9 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC90319.1 - 1.2e-14 53.7 72.1 0.013 16.2 0.9 9.6 9 0 0 9 9 9 8 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMC90319.1 - 0.0062 16.9 4.7 0.0062 16.9 4.7 10.6 11 1 0 11 11 11 3 Zinc-finger double domain zf-C2HE PF16278.5 EMC90319.1 - 0.012 16.1 33.3 0.025 15.0 0.0 6.4 5 2 1 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.7 EMC90319.1 - 0.17 12.3 43.0 0.042 14.3 2.4 7.8 8 0 0 8 8 8 0 Zinc-finger of C2H2 type zf-MYST PF17772.1 EMC90319.1 - 0.54 9.9 0.0 0.54 9.9 0.0 6.4 8 1 1 9 9 9 0 MYST family zinc finger domain Desulfoferrod_N PF06397.12 EMC90319.1 - 1.5 8.5 7.5 46 3.7 0.1 4.5 4 0 0 4 4 4 0 Desulfoferrodoxin, N-terminal domain zf-C2H2_6 PF13912.6 EMC90319.1 - 2.5 8.2 51.4 0.51 10.4 0.5 8.2 9 0 0 9 9 9 0 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 EMC90319.1 - 2.5 8.8 35.1 2 9.1 1.6 7.7 4 3 2 7 7 7 0 Zinc finger C2H2-type, 3 repeats PRIMA1 PF16101.5 EMC90319.1 - 4.9 7.2 8.3 14 5.7 8.3 1.8 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 zf-CHCC PF10276.9 EMC90319.1 - 5.8 7.1 9.8 3.5 7.8 0.2 3.4 3 0 0 3 3 3 0 Zinc-finger domain zf-C2H2_11 PF16622.5 EMC90319.1 - 7.4 6.4 31.0 1.6 8.6 0.4 6.5 7 0 0 7 7 7 0 zinc-finger C2H2-type Actin PF00022.19 EMC90320.1 - 2.1e-86 290.1 0.0 1.9e-51 175.0 0.0 2.0 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 EMC90320.1 - 2e-05 23.6 0.0 0.038 12.8 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 EMC90320.1 - 0.0088 16.4 0.0 0.021 15.2 0.0 1.7 1 1 0 1 1 1 1 Cell division protein FtsA Robl_LC7 PF03259.17 EMC90320.1 - 0.071 12.9 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Roadblock/LC7 domain Rad51 PF08423.11 EMC90321.1 - 5.5e-20 71.7 0.0 6.5e-20 71.5 0.0 1.0 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EMC90321.1 - 0.0048 16.4 0.0 0.0098 15.4 0.0 1.4 2 0 0 2 2 2 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 EMC90321.1 - 0.015 14.9 0.0 0.028 14.0 0.0 1.4 1 1 0 1 1 1 0 AAA domain PID PF00640.23 EMC90323.1 - 1e-34 119.6 0.0 1.1e-34 119.4 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Delta_lysin PF05372.11 EMC90323.1 - 0.016 14.5 0.1 0.039 13.2 0.1 1.6 1 0 0 1 1 1 0 Delta lysin family PTB PF08416.13 EMC90323.1 - 0.1 12.8 0.0 0.12 12.5 0.0 1.1 1 0 0 1 1 1 0 Phosphotyrosine-binding domain PAPS_reduct PF01507.19 EMC90324.1 - 1.3e-31 110.0 0.0 6.1e-21 75.2 0.0 2.2 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family MoCF_biosynth PF00994.24 EMC90324.1 - 9.2e-27 93.5 0.0 2e-26 92.4 0.0 1.5 1 0 0 1 1 1 1 Probable molybdopterin binding domain ATP_bind_3 PF01171.20 EMC90324.1 - 0.17 11.6 0.0 1 9.1 0.0 2.0 1 1 1 2 2 2 0 PP-loop family Ephrin PF00812.17 EMC90327.1 - 2.5e-32 111.8 2.1 2.7e-32 111.6 2.1 1.0 1 0 0 1 1 1 1 Ephrin Ephrin PF00812.17 EMC90328.1 - 1.1e-31 109.7 0.6 1.2e-31 109.5 0.6 1.0 1 0 0 1 1 1 1 Ephrin Keratin_assoc PF09775.9 EMC90329.1 - 2.8e-52 175.8 10.4 3e-52 175.6 10.4 1.0 1 0 0 1 1 1 1 Keratinocyte-associated protein 2 EptA_B_N PF08019.12 EMC90329.1 - 0.26 11.2 6.8 2.6 7.9 3.2 2.0 2 0 0 2 2 2 0 Phosphoethanolamine transferase EptA/EptB DUF5408 PF17402.2 EMC90329.1 - 0.29 11.0 4.8 0.12 12.2 1.7 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5408) DUF1656 PF07869.12 EMC90329.1 - 4.1 7.5 8.6 0.9 9.6 0.8 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1656) Trypan_PARP PF05887.11 EMC90330.1 - 0.59 10.1 56.1 0.45 10.5 19.1 3.9 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) TSP_C PF05735.12 EMC90331.1 - 1.9e-70 236.9 0.7 2.5e-70 236.4 0.7 1.2 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.18 EMC90331.1 - 4.6e-61 202.2 133.3 1.5e-14 53.4 10.3 9.5 7 2 1 8 8 8 7 Thrombospondin type 3 repeat EGF_CA PF07645.15 EMC90331.1 - 1.9e-12 47.1 21.3 1e-07 32.1 2.1 5.6 5 0 0 5 5 5 2 Calcium-binding EGF domain COMP PF11598.8 EMC90331.1 - 2.7e-07 30.9 0.8 5.9e-07 29.9 0.8 1.5 1 0 0 1 1 1 1 Cartilage oligomeric matrix protein cEGF PF12662.7 EMC90331.1 - 3.7e-07 30.0 33.6 0.00023 21.0 0.7 5.4 4 0 0 4 4 4 2 Complement Clr-like EGF-like EGF_3 PF12947.7 EMC90331.1 - 3.2e-06 27.2 5.2 3.2e-06 27.2 5.2 7.2 4 2 1 5 5 5 3 EGF domain EGF PF00008.27 EMC90331.1 - 0.0011 19.2 5.0 0.0011 19.2 5.0 5.2 4 0 0 4 4 4 2 EGF-like domain Laminin_G_2 PF02210.24 EMC90331.1 - 0.067 13.8 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain GST_C_6 PF17171.4 EMC90332.1 - 9.3e-23 79.8 0.2 1.1e-22 79.6 0.2 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EMC90332.1 - 0.00064 19.7 0.1 0.00083 19.3 0.1 1.3 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glyco_hydro_30 PF02055.16 EMC90333.1 - 9.2e-164 544.5 0.3 1.1e-163 544.2 0.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C PF17189.4 EMC90333.1 - 3.1e-08 33.7 0.0 5.2e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Glyco_hydro_59 PF02057.15 EMC90333.1 - 4e-08 32.8 0.1 5.8e-08 32.3 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 DUF229 PF02995.17 EMC90333.1 - 0.091 11.4 0.0 0.13 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Pkinase PF00069.25 EMC90334.1 - 8.4e-51 172.8 0.1 1.1e-50 172.5 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC90334.1 - 5.6e-21 75.0 0.1 2e-20 73.2 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase polyprenyl_synt PF00348.17 EMC90336.1 - 2.8e-92 308.4 0.0 3.5e-92 308.1 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase RUN PF02759.19 EMC90337.1 - 5.7e-17 61.9 0.0 8.3e-17 61.4 0.0 1.2 1 0 0 1 1 1 1 RUN domain SH3_1 PF00018.28 EMC90337.1 - 6e-10 38.6 1.0 1.2e-09 37.6 0.0 2.1 3 0 0 3 3 3 1 SH3 domain SH3_9 PF14604.6 EMC90337.1 - 5.1e-09 35.9 0.0 1.4e-08 34.4 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMC90337.1 - 7.7e-09 35.1 0.1 2.9e-08 33.3 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain DAP3 PF10236.9 EMC90338.1 - 2.9e-91 305.9 0.0 3.6e-91 305.6 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_25 PF13481.6 EMC90338.1 - 0.0019 17.8 0.0 0.0049 16.5 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EMC90338.1 - 0.0064 16.9 0.0 0.015 15.7 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EMC90338.1 - 0.02 14.8 0.0 0.075 12.9 0.0 2.0 2 0 0 2 2 2 0 NACHT domain ATPase_2 PF01637.18 EMC90338.1 - 0.029 14.3 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea ResIII PF04851.15 EMC90338.1 - 0.036 14.0 0.0 0.056 13.4 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DUF2075 PF09848.9 EMC90338.1 - 0.048 12.9 0.0 0.073 12.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) CbiA PF01656.23 EMC90338.1 - 0.067 13.2 0.0 0.15 12.1 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain IstB_IS21 PF01695.17 EMC90338.1 - 0.069 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 EMC90338.1 - 0.17 11.5 0.0 0.34 10.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain C2 PF00168.30 EMC90339.1 - 1.8e-44 150.2 0.0 6.2e-21 74.6 0.0 2.4 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.6 EMC90339.1 - 0.00013 21.6 0.0 0.049 13.2 0.0 2.6 2 1 0 2 2 2 2 CEP76 C2 domain CoatB PF10389.9 EMC90339.1 - 0.056 13.3 2.8 0.12 12.3 2.8 1.5 1 0 0 1 1 1 0 Bacteriophage coat protein B Ras PF00071.22 EMC90340.1 - 6.4e-44 149.4 0.0 7.6e-44 149.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC90340.1 - 6.1e-12 45.8 0.0 1.5e-11 44.6 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC90340.1 - 0.00017 21.1 0.0 0.0002 20.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC90340.1 - 0.0011 18.6 0.0 0.0013 18.3 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain baeRF_family3 PF18845.1 EMC90340.1 - 0.091 13.0 0.0 0.15 12.3 0.0 1.5 1 1 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 3 HORMA PF02301.18 EMC90341.1 - 2.8e-60 203.5 0.0 4.4e-60 202.9 0.0 1.3 1 0 0 1 1 1 1 HORMA domain GPP34 PF05719.11 EMC90342.1 - 6.6e-57 192.8 4.6 8.2e-57 192.5 4.6 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) Endosulfine PF04667.17 EMC90343.1 - 2.9e-11 43.4 2.2 3.6e-11 43.0 2.2 1.1 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Bcl-2 PF00452.19 EMC90344.1 - 3.2e-19 69.4 0.3 4.7e-19 68.9 0.3 1.3 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family BALF1 PF06861.11 EMC90344.1 - 0.065 12.9 0.0 0.083 12.5 0.0 1.1 1 0 0 1 1 1 0 BALF1 protein Phosphorylase PF00343.20 EMC90345.1 - 5.1e-60 203.6 9.5 4.5e-37 127.7 2.6 3.0 2 1 1 3 3 3 3 Carbohydrate phosphorylase VASP_tetra PF08776.11 EMC90346.1 - 1.3e-11 43.8 2.9 2.7e-11 42.8 2.9 1.5 1 0 0 1 1 1 1 VASP tetramerisation domain Cornichon PF03311.14 EMC90348.1 - 1.9e-29 102.4 4.8 1.8e-28 99.3 4.8 1.9 1 1 0 1 1 1 1 Cornichon protein WD40 PF00400.32 EMC90349.1 - 2.1e-28 98.0 10.9 6.4e-06 26.8 0.0 6.3 5 1 1 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC90349.1 - 8.3e-09 35.6 0.2 0.12 12.7 0.0 5.1 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC90349.1 - 1.3e-05 25.2 0.0 0.00029 20.8 0.0 2.4 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EMC90349.1 - 0.003 16.6 0.1 0.032 13.2 0.0 2.5 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EMC90349.1 - 0.058 13.4 0.1 72 3.5 0.1 4.2 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Cornichon PF03311.14 EMC90351.1 - 2e-42 144.4 2.5 2.3e-42 144.2 2.5 1.0 1 0 0 1 1 1 1 Cornichon protein DUF2650 PF10853.8 EMC90351.1 - 0.47 10.2 3.6 2.5 7.9 3.6 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2650) AAA PF00004.29 EMC90352.1 - 2.4e-93 309.5 0.0 2.8e-48 163.7 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMC90352.1 - 1e-26 92.4 0.4 1.6e-12 47.0 0.0 2.8 2 0 0 2 2 2 2 AAA+ lid domain Nucleolin_bd PF16725.5 EMC90352.1 - 2.2e-21 75.3 0.1 4.2e-21 74.4 0.1 1.5 1 0 0 1 1 1 1 Nucleolin binding domain RuvB_N PF05496.12 EMC90352.1 - 1.9e-13 50.4 0.0 1.5e-05 24.8 0.0 3.1 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EMC90352.1 - 1.6e-12 48.2 3.6 0.012 16.0 0.0 5.3 3 2 2 5 5 5 2 AAA ATPase domain AAA_2 PF07724.14 EMC90352.1 - 2.8e-12 47.1 0.0 4.9e-05 23.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EMC90352.1 - 4.5e-11 43.2 4.1 0.0012 19.1 0.1 5.0 4 2 1 5 5 3 2 AAA domain AAA_5 PF07728.14 EMC90352.1 - 2.4e-10 40.5 1.0 0.0001 22.3 0.1 3.7 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EMC90352.1 - 6.9e-09 35.4 0.0 0.0043 16.3 0.0 2.7 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_14 PF13173.6 EMC90352.1 - 1.7e-08 34.5 0.0 0.0057 16.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 EMC90352.1 - 5.1e-08 33.2 0.0 0.0045 17.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EMC90352.1 - 1.2e-07 31.3 0.2 0.0077 15.6 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EMC90352.1 - 6.9e-07 29.6 0.0 0.05 14.0 0.0 3.1 2 1 0 2 2 2 2 RNA helicase AAA_28 PF13521.6 EMC90352.1 - 9e-07 29.3 0.0 0.035 14.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 EMC90352.1 - 3.2e-06 27.0 0.0 0.083 12.6 0.1 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein Viral_helicase1 PF01443.18 EMC90352.1 - 3.4e-06 27.0 0.0 0.066 12.9 0.0 2.4 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Zeta_toxin PF06414.12 EMC90352.1 - 3.7e-06 26.4 0.1 0.0036 16.6 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin AAA_18 PF13238.6 EMC90352.1 - 4e-06 27.4 0.0 0.023 15.3 0.0 2.9 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 EMC90352.1 - 5.1e-06 26.5 0.6 0.045 13.7 0.0 3.1 3 1 0 3 3 2 2 NACHT domain TsaE PF02367.17 EMC90352.1 - 5.4e-06 26.4 0.0 0.056 13.5 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EMC90352.1 - 2.8e-05 24.7 0.0 0.25 11.8 0.0 3.0 2 0 0 2 2 2 2 ABC transporter Rad17 PF03215.15 EMC90352.1 - 2.8e-05 24.1 0.1 0.1 12.5 0.0 2.9 2 1 1 3 3 3 2 Rad17 P-loop domain AAA_3 PF07726.11 EMC90352.1 - 4e-05 23.5 0.0 0.26 11.1 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 EMC90352.1 - 4.4e-05 23.9 0.0 0.53 10.7 0.0 3.0 2 0 0 2 2 2 2 AAA domain ATPase PF06745.13 EMC90352.1 - 5.1e-05 22.7 0.9 0.68 9.2 0.0 3.6 2 1 1 3 3 3 1 KaiC Sigma54_activat PF00158.26 EMC90352.1 - 0.00027 20.7 0.0 0.41 10.3 0.0 3.4 2 1 0 2 2 2 1 Sigma-54 interaction domain NB-ARC PF00931.22 EMC90352.1 - 0.00035 19.8 0.0 1.1 8.4 0.0 2.7 3 0 0 3 3 3 2 NB-ARC domain Sigma54_activ_2 PF14532.6 EMC90352.1 - 0.00038 20.6 0.0 0.94 9.6 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain Cytidylate_kin2 PF13189.6 EMC90352.1 - 0.00038 20.6 0.0 0.31 11.1 0.0 2.4 2 0 0 2 2 2 1 Cytidylate kinase-like family AAA_25 PF13481.6 EMC90352.1 - 0.00052 19.7 4.8 1.6 8.3 0.2 4.1 2 2 1 4 4 4 2 AAA domain PhoH PF02562.16 EMC90352.1 - 0.0018 17.7 0.2 1.5 8.2 0.0 2.8 3 0 0 3 3 3 1 PhoH-like protein AAA_7 PF12775.7 EMC90352.1 - 0.0024 17.4 0.1 2.8 7.4 0.0 2.7 2 1 0 2 2 2 1 P-loop containing dynein motor region DUF815 PF05673.13 EMC90352.1 - 0.0055 15.9 0.0 0.34 10.0 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) PduV-EutP PF10662.9 EMC90352.1 - 0.0059 16.4 0.0 2.9 7.6 0.0 2.5 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation DUF2075 PF09848.9 EMC90352.1 - 0.0059 15.9 0.0 1.1 8.4 0.0 2.7 3 0 0 3 3 2 1 Uncharacterized conserved protein (DUF2075) Parvo_NS1 PF01057.17 EMC90352.1 - 0.0089 15.2 0.0 2.5 7.1 0.0 2.4 3 0 0 3 3 2 1 Parvovirus non-structural protein NS1 NTPase_1 PF03266.15 EMC90352.1 - 0.012 15.6 0.0 6.2 6.7 0.0 3.0 2 1 1 3 3 3 0 NTPase SKI PF01202.22 EMC90352.1 - 0.014 15.5 0.0 2.5 8.2 0.0 2.9 3 0 0 3 3 2 0 Shikimate kinase AAA_24 PF13479.6 EMC90352.1 - 0.017 14.8 0.0 4.5 7.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EMC90352.1 - 0.021 14.7 0.0 12 5.7 0.0 3.3 2 2 2 4 4 4 0 ATPase domain predominantly from Archaea AAA_11 PF13086.6 EMC90352.1 - 0.022 14.5 3.6 1.8 8.3 0.0 2.8 3 1 0 3 3 2 0 AAA domain AAA_19 PF13245.6 EMC90352.1 - 0.026 14.9 1.1 6.5 7.1 0.1 2.7 2 1 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EMC90352.1 - 0.044 13.5 0.0 6.7 6.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain Zot PF05707.12 EMC90352.1 - 0.088 12.4 0.0 3.4 7.3 0.0 3.0 2 2 0 3 3 2 0 Zonular occludens toxin (Zot) Vps4_C PF09336.10 EMC90352.1 - 0.093 12.7 0.0 0.78 9.8 0.0 2.4 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain DAP3 PF10236.9 EMC90352.1 - 0.15 11.2 0.1 5.8 6.0 0.0 2.7 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 FA_desaturase PF00487.24 EMC90353.1 - 5.1e-25 88.8 13.7 5.1e-25 88.8 13.7 1.6 2 0 0 2 2 2 1 Fatty acid desaturase Lipid_DES PF08557.10 EMC90353.1 - 0.0021 17.5 0.2 0.0043 16.5 0.2 1.6 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) ATG16 PF08614.11 EMC90354.1 - 2.7e-05 24.5 3.1 2.7e-05 24.5 3.1 1.8 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) FAM76 PF16046.5 EMC90354.1 - 8.6e-05 22.0 1.2 0.00016 21.2 1.2 1.6 1 0 0 1 1 1 1 FAM76 protein DUF3287 PF11690.8 EMC90354.1 - 0.0029 17.3 1.4 0.011 15.5 0.3 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3287) SlyX PF04102.12 EMC90354.1 - 0.0038 17.8 8.5 0.0038 17.8 8.5 2.7 2 1 1 3 3 3 1 SlyX Spc7 PF08317.11 EMC90354.1 - 0.0063 15.4 8.2 0.012 14.6 8.2 1.4 1 0 0 1 1 1 1 Spc7 kinetochore protein Filament PF00038.21 EMC90354.1 - 0.0073 15.9 8.2 0.015 14.9 8.2 1.4 1 0 0 1 1 1 1 Intermediate filament protein TMF_DNA_bd PF12329.8 EMC90354.1 - 0.07 13.1 11.4 0.61 10.1 7.1 2.6 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF3450 PF11932.8 EMC90354.1 - 0.13 11.6 9.1 0.3 10.4 9.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF16 PF01519.16 EMC90354.1 - 0.15 12.5 8.0 0.047 14.2 4.5 1.9 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF2730 PF10805.8 EMC90354.1 - 0.2 11.7 3.3 1.6 8.9 3.3 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) SKA1 PF07160.12 EMC90354.1 - 0.23 11.3 8.9 0.48 10.2 8.9 1.6 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 HemX PF04375.14 EMC90354.1 - 0.36 10.1 9.9 0.75 9.0 9.9 1.5 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase YabA PF06156.13 EMC90354.1 - 0.66 10.6 7.2 3.2 8.4 5.0 2.5 1 1 1 2 2 2 0 Initiation control protein YabA DUF4407 PF14362.6 EMC90354.1 - 0.69 9.2 5.2 1.2 8.4 5.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) COG2 PF06148.11 EMC90354.1 - 1.4 9.0 6.7 3.9 7.6 3.8 2.7 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 ABC_tran_CTD PF16326.5 EMC90354.1 - 1.6 9.1 11.0 6.4 7.1 10.9 2.1 1 1 0 1 1 1 0 ABC transporter C-terminal domain FlaC_arch PF05377.11 EMC90354.1 - 2 8.8 4.8 1.5 9.3 1.9 2.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) OmpH PF03938.14 EMC90354.1 - 2.4 8.5 15.2 2.1 8.7 13.4 1.8 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) NPV_P10 PF05531.12 EMC90354.1 - 3.6 8.1 10.2 12 6.4 8.3 2.6 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein KASH_CCD PF14662.6 EMC90354.1 - 3.9 7.3 17.1 1.2 8.9 3.4 2.6 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH TMF_TATA_bd PF12325.8 EMC90354.1 - 4.7 7.5 14.5 3.8 7.8 11.3 2.3 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Ank_2 PF12796.7 EMC90355.1 - 4.6e-17 62.4 0.0 9.8e-17 61.3 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC90355.1 - 7.1e-17 61.6 0.0 2.1e-11 44.1 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EMC90355.1 - 5.2e-14 52.0 0.0 5e-06 26.7 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 EMC90355.1 - 1.1e-13 50.0 0.0 3.9e-05 23.7 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat SH3_1 PF00018.28 EMC90355.1 - 8.6e-12 44.5 1.6 1.7e-11 43.5 1.6 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMC90355.1 - 6.7e-10 38.7 0.5 1.5e-09 37.6 0.5 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ank_5 PF13857.6 EMC90355.1 - 7.1e-10 38.9 0.6 4.7e-08 33.2 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SH3_2 PF07653.17 EMC90355.1 - 3.5e-07 29.8 0.0 6.6e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Peptidase_C2 PF00648.21 EMC90356.1 - 3.4e-126 420.2 0.0 7.7e-125 415.8 0.0 2.1 2 0 0 2 2 2 1 Calpain family cysteine protease Calpain_III PF01067.22 EMC90356.1 - 1.5e-38 132.2 0.1 2.8e-38 131.4 0.1 1.5 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_1 PF00036.32 EMC90356.1 - 2.9e-12 45.2 1.0 0.0082 15.6 0.0 4.7 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 EMC90356.1 - 1.5e-10 40.8 4.3 1.2e-08 34.6 0.2 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EMC90356.1 - 6e-10 38.3 1.6 0.058 13.3 0.0 4.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 EMC90356.1 - 3e-05 24.4 3.6 0.11 13.0 0.1 3.9 1 1 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 EMC90356.1 - 0.15 11.6 1.0 5.4 6.7 0.1 3.3 4 0 0 4 4 4 0 EF hand Peptidase_C2 PF00648.21 EMC90357.1 - 1e-129 431.8 0.0 2e-129 430.9 0.0 1.5 2 0 0 2 2 2 1 Calpain family cysteine protease Calpain_III PF01067.22 EMC90357.1 - 6.5e-50 169.1 0.0 2.1e-49 167.4 0.0 1.8 2 0 0 2 2 2 1 Calpain large subunit, domain III EF-hand_1 PF00036.32 EMC90357.1 - 9.7e-10 37.3 0.4 0.027 14.0 0.0 4.4 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 EMC90357.1 - 2.4e-08 33.2 0.2 0.014 15.2 0.0 4.9 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 EMC90357.1 - 4.3e-07 29.7 3.2 1.8e-05 24.5 0.1 3.8 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_7 PF13499.6 EMC90357.1 - 0.0022 18.4 1.6 0.87 10.1 0.1 4.0 2 2 0 2 2 2 1 EF-hand domain pair Alpha_adaptin_C PF02296.16 EMC90357.1 - 0.09 13.0 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Alpha adaptin AP2, C-terminal domain DUF4300 PF14133.6 EMC90357.1 - 0.1 12.3 0.4 0.19 11.4 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4300) Sushi PF00084.20 EMC90358.1 - 3.4e-34 117.2 22.4 1.4e-08 35.2 0.2 4.2 4 0 0 4 4 4 4 Sushi repeat (SCR repeat) cEGF PF12662.7 EMC90358.1 - 0.0037 17.2 15.1 4.1 7.4 0.1 5.5 5 0 0 5 5 5 4 Complement Clr-like EGF-like HRM PF02793.22 EMC90358.1 - 0.41 11.0 7.4 1.3 9.4 0.1 3.8 4 0 0 4 4 4 0 Hormone receptor domain LRR_8 PF13855.6 EMC90359.1 - 1.5e-47 159.2 67.9 2.2e-12 46.5 9.5 11.5 7 4 6 13 13 13 6 Leucine rich repeat TIR PF01582.20 EMC90359.1 - 5.7e-25 88.1 1.5 9.5e-25 87.4 1.5 1.3 1 0 0 1 1 1 1 TIR domain LRR_4 PF12799.7 EMC90359.1 - 2.4e-18 65.9 62.6 1.9e-05 24.9 3.4 10.2 9 2 3 12 12 12 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC90359.1 - 2e-17 63.4 7.9 1.3e-08 34.9 0.8 4.0 4 1 0 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC90359.1 - 2.7e-11 43.3 17.7 0.011 15.2 0.1 5.6 4 2 2 6 6 6 5 Leucine-rich repeat TIR_2 PF13676.6 EMC90359.1 - 6.8e-10 39.6 0.1 2.3e-09 37.9 0.1 1.9 1 0 0 1 1 1 1 TIR domain LRR_1 PF00560.33 EMC90359.1 - 0.0002 21.4 51.7 0.72 10.6 0.2 13.2 13 2 1 14 14 14 5 Leucine Rich Repeat LRR_6 PF13516.6 EMC90359.1 - 0.0019 18.1 58.6 0.92 9.7 0.0 13.7 15 0 0 15 15 15 4 Leucine Rich repeat BRO1 PF03097.18 EMC90360.1 - 1.9e-40 138.9 0.1 2.6e-40 138.5 0.1 1.1 1 0 0 1 1 1 1 BRO1-like domain Aida_C2 PF14186.6 EMC90361.1 - 5.2e-65 217.5 0.3 7e-65 217.1 0.3 1.2 1 0 0 1 1 1 1 Cytoskeletal adhesion Aida_N PF08910.10 EMC90361.1 - 1.7e-23 83.0 1.2 3.3e-23 82.0 1.2 1.4 1 0 0 1 1 1 1 Aida N-terminus NPIP PF06409.11 EMC90362.1 - 2.4e-13 49.8 32.0 1.7e-09 37.1 9.6 3.2 2 1 0 2 2 2 2 Nuclear pore complex interacting protein (NPIP) MscS_porin PF12795.7 EMC90362.1 - 0.00048 19.7 30.8 0.00048 19.7 30.8 3.0 2 1 1 3 3 3 1 Mechanosensitive ion channel porin domain KELK PF15796.5 EMC90362.1 - 0.012 16.0 11.9 0.012 16.0 11.9 6.6 3 2 5 8 8 8 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF508 PF04370.12 EMC90362.1 - 0.04 13.7 0.0 0.087 12.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF508) bZIP_2 PF07716.15 EMC90362.1 - 0.059 13.5 0.2 0.059 13.5 0.2 8.5 9 1 0 9 9 9 0 Basic region leucine zipper Taxilin PF09728.9 EMC90362.1 - 7.2 5.7 91.3 0.24 10.6 13.4 4.0 2 2 1 3 3 3 0 Myosin-like coiled-coil protein SH3_2 PF07653.17 EMC90363.1 - 1e-09 37.9 0.0 1.4e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EMC90363.1 - 0.069 13.0 0.4 2.2 8.2 0.0 2.3 2 1 0 2 2 2 0 Variant SH3 domain TAF1_subA PF14929.6 EMC90364.1 - 5.6e-123 411.0 15.3 6.5e-123 410.8 15.3 1.0 1 0 0 1 1 1 1 TAF RNA Polymerase I subunit A TPR_14 PF13428.6 EMC90364.1 - 0.03 15.1 0.1 0.4 11.6 0.0 2.9 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EMC90364.1 - 0.16 12.5 0.3 1.2 9.7 0.0 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat GSDH PF07995.11 EMC90365.1 - 3e-38 132.0 0.0 4.3e-38 131.5 0.0 1.1 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase Folate_rec PF03024.14 EMC90365.1 - 9.1e-10 38.7 11.7 1.6e-09 37.9 11.7 1.4 1 0 0 1 1 1 1 Folate receptor family DSPc PF00782.20 EMC90366.1 - 2.2e-42 144.0 0.4 5.8e-42 142.7 0.0 1.9 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 EMC90366.1 - 1.1e-14 54.9 0.0 3e-13 50.2 0.0 2.4 2 0 0 2 2 2 1 Rhodanese-like domain PTPlike_phytase PF14566.6 EMC90366.1 - 1e-05 25.7 0.0 2.2e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 EMC90366.1 - 9e-05 22.1 0.1 0.0024 17.5 0.0 2.2 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 EMC90366.1 - 0.0014 18.9 0.5 0.017 15.4 0.0 2.7 3 0 0 3 3 3 1 Rit1 DUSP-like domain AAA_18 PF13238.6 EMC90366.1 - 0.15 12.6 0.0 7.5 7.1 0.0 2.3 1 1 1 2 2 2 0 AAA domain I-set PF07679.16 EMC90367.1 - 6.9e-115 375.4 0.3 5.3e-15 55.3 0.0 10.6 11 0 0 11 11 11 8 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC90367.1 - 7.1e-108 353.4 10.0 3.5e-16 59.6 0.2 10.2 10 0 0 10 10 9 8 Immunoglobulin domain Ig_2 PF13895.6 EMC90367.1 - 8.7e-80 263.1 7.3 4.5e-10 39.7 0.0 9.5 9 0 0 9 9 9 8 Immunoglobulin domain fn3 PF00041.21 EMC90367.1 - 3.3e-79 261.3 6.8 5e-14 52.4 0.0 7.9 7 0 0 7 7 7 6 Fibronectin type III domain ig PF00047.25 EMC90367.1 - 2.5e-70 232.7 2.5 8.3e-09 35.5 0.0 9.4 9 0 0 9 9 9 8 Immunoglobulin domain V-set PF07686.17 EMC90367.1 - 3.1e-31 107.8 21.8 0.0018 18.5 0.1 14.0 8 7 1 9 9 9 8 Immunoglobulin V-set domain Ig_5 PF16681.5 EMC90367.1 - 1.3e-19 70.4 0.0 0.084 13.3 0.0 9.2 8 1 0 8 8 8 4 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 EMC90367.1 - 1.4e-15 57.1 1.5 0.19 11.8 0.0 8.7 8 0 0 8 8 8 4 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 EMC90367.1 - 6.8e-15 54.4 0.5 0.63 9.6 0.0 7.8 8 0 0 8 8 8 4 Immunoglobulin domain Ig_4 PF16680.5 EMC90367.1 - 1.8e-11 44.2 0.3 1.5 9.2 0.0 8.8 8 2 0 8 8 8 2 T-cell surface glycoprotein CD3 delta chain C1-set PF07654.15 EMC90367.1 - 5.4e-09 36.3 1.6 0.67 10.4 0.0 7.4 7 0 0 7 7 6 1 Immunoglobulin C1-set domain Interfer-bind PF09294.10 EMC90367.1 - 1.1e-07 32.1 0.1 0.11 12.8 0.0 5.0 5 0 0 5 5 5 2 Interferon-alpha/beta receptor, fibronectin type III Pur_ac_phosph_N PF16656.5 EMC90367.1 - 2.2e-06 28.2 11.0 0.42 11.2 0.0 7.3 7 1 0 7 7 7 2 Purple acid Phosphatase, N-terminal domain Izumo-Ig PF16706.5 EMC90367.1 - 2.3e-06 27.6 0.5 28 4.9 0.0 6.9 7 0 0 7 7 7 0 Izumo-like Immunoglobulin domain Ig_C17orf99 PF17736.1 EMC90367.1 - 3.9e-06 26.8 0.0 4.8 7.3 0.0 6.5 6 1 0 6 6 6 1 C17orf99 Ig domain Receptor_2B4 PF11465.8 EMC90367.1 - 4.7e-06 26.8 0.1 4.2 7.6 0.0 5.5 6 0 0 6 6 5 2 Natural killer cell receptor 2B4 ChitinaseA_N PF08329.10 EMC90367.1 - 5.5e-06 26.1 0.0 0.0026 17.4 0.0 3.0 2 0 0 2 2 2 1 Chitinase A, N-terminal domain V-set_CD47 PF08204.11 EMC90367.1 - 0.00024 21.1 1.1 1.8 8.5 0.0 5.8 7 0 0 7 7 7 1 CD47 immunoglobulin-like domain EphA2_TM PF14575.6 EMC90367.1 - 0.13 13.2 0.1 0.29 12.0 0.1 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Adeno_E3_CR1 PF02440.15 EMC90367.1 - 0.2 11.5 0.0 0.2 11.5 0.0 4.2 6 0 0 6 6 4 0 Adenovirus E3 region protein CR1 DUF4446 PF14584.6 EMC90367.1 - 0.57 10.2 2.2 0.94 9.4 0.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Ig_3 PF13927.6 EMC90368.1 - 3.9e-16 59.4 0.7 6.2e-07 29.9 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC90368.1 - 5e-14 52.1 0.1 2.9e-06 27.3 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC90368.1 - 5.5e-10 39.4 0.6 0.00016 22.0 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 EMC90368.1 - 4.2e-09 36.4 1.8 0.0014 18.7 0.2 2.5 2 1 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 EMC90368.1 - 5.4e-07 29.6 0.5 0.00027 20.9 0.0 2.4 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain TMEM52 PF14979.6 EMC90368.1 - 0.00014 21.9 0.3 0.00026 20.9 0.3 1.5 1 0 0 1 1 1 1 Transmembrane 52 V-set PF07686.17 EMC90368.1 - 0.00029 21.0 1.1 0.055 13.6 0.1 2.8 2 2 0 2 2 2 1 Immunoglobulin V-set domain TMEM154 PF15102.6 EMC90368.1 - 0.0014 18.5 0.6 0.003 17.5 0.6 1.5 1 0 0 1 1 1 1 TMEM154 protein family C1-set PF07654.15 EMC90368.1 - 0.0022 18.3 0.1 0.0094 16.3 0.0 2.2 1 1 2 3 3 3 1 Immunoglobulin C1-set domain Collectrin PF16959.5 EMC90368.1 - 0.0036 17.1 2.3 0.0071 16.1 2.3 1.4 1 0 0 1 1 1 1 Renal amino acid transporter Shisa PF13908.6 EMC90368.1 - 0.0049 17.1 2.1 0.01 16.1 2.1 1.5 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator LRR19-TM PF15176.6 EMC90368.1 - 0.0058 16.6 0.5 0.015 15.3 0.5 1.6 1 0 0 1 1 1 1 Leucine-rich repeat family 19 TM domain Protocadherin PF08374.11 EMC90368.1 - 0.022 14.8 1.0 0.037 14.0 1.0 1.3 1 0 0 1 1 1 0 Protocadherin BPA_C PF18040.1 EMC90368.1 - 0.051 13.5 0.2 0.22 11.5 0.1 2.0 1 1 1 2 2 2 0 beta porphyranase A C-terminal Orthoreo_P10 PF07204.11 EMC90368.1 - 0.055 13.4 0.5 0.11 12.5 0.5 1.5 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 UPF0139 PF03669.13 EMC90368.1 - 0.064 13.1 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0139) Marek_A PF02124.15 EMC90368.1 - 0.067 13.0 7.1 0.16 11.8 7.1 1.6 1 1 0 1 1 1 0 Marek's disease glycoprotein A DUF2207 PF09972.9 EMC90368.1 - 0.093 11.5 0.2 0.17 10.6 0.1 1.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) EphA2_TM PF14575.6 EMC90368.1 - 2.3 9.1 3.8 5 8.1 3.8 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMIE PF16038.5 EMC90368.1 - 6.2 6.7 9.2 12 5.8 9.2 1.4 1 0 0 1 1 1 0 TMIE protein Galactosyl_T PF01762.21 EMC90369.1 - 7.6e-56 189.0 0.2 9.6e-56 188.7 0.2 1.1 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 EMC90369.1 - 0.0031 17.0 0.1 0.0041 16.6 0.1 1.2 1 0 0 1 1 1 1 Fringe-like CNOT1_HEAT PF16418.5 EMC90369.1 - 0.067 13.3 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 1 HEAT repeat SH3BGR PF04908.15 EMC90370.1 - 3.8e-47 158.5 0.1 4.9e-47 158.2 0.1 1.1 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 EMC90370.1 - 0.00068 19.8 0.0 0.0012 19.1 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Cys_rich_CWC PF14375.6 EMC90370.1 - 0.049 14.0 0.5 0.078 13.4 0.5 1.3 1 0 0 1 1 1 0 Cysteine-rich CWC Lebercilin PF15619.6 EMC90371.1 - 2.4e-58 197.0 33.5 2.4e-58 197.0 33.5 2.6 2 1 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease RBP_receptor PF14752.6 EMC90371.1 - 2.1 6.8 7.0 0.082 11.5 0.7 1.7 2 0 0 2 2 2 0 Retinol binding protein receptor CHD5 PF04420.14 EMC90372.1 - 1.2e-36 126.0 0.6 1.3e-36 125.9 0.6 1.0 1 0 0 1 1 1 1 CHD5-like protein DUF1043 PF06295.12 EMC90372.1 - 0.0027 17.7 0.8 0.0035 17.4 0.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1043) DUF2203 PF09969.9 EMC90372.1 - 0.0058 17.3 1.4 0.24 12.1 0.5 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2203) MCU PF04678.13 EMC90372.1 - 0.098 12.7 5.5 0.73 9.9 5.5 1.9 1 1 0 1 1 1 0 Mitochondrial calcium uniporter DUF1640 PF07798.11 EMC90372.1 - 0.19 11.8 6.8 0.32 11.0 6.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) HMG14_17 PF01101.18 EMC90373.1 - 2.9e-17 63.4 24.2 3.4e-17 63.2 24.2 1.0 1 0 0 1 1 1 1 HMG14 and HMG17 Bromodomain PF00439.25 EMC90374.1 - 3.1e-37 126.5 0.1 2.2e-17 62.9 0.0 2.6 2 0 0 2 2 2 2 Bromodomain WD40 PF00400.32 EMC90374.1 - 3.2e-34 116.4 15.8 8.1e-06 26.5 0.6 8.9 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC90374.1 - 8.3e-06 26.0 0.3 0.76 10.1 0.1 5.2 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMC90374.1 - 0.12 12.2 0.1 2.7 7.8 0.0 2.5 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A PAC1 PF16094.5 EMC90375.1 - 7.1e-137 455.2 2.5 7.9e-137 455.1 2.5 1.0 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 Ets PF00178.22 EMC90376.1 - 1.7e-36 124.5 1.1 1.7e-36 124.5 1.1 2.6 3 0 0 3 3 3 1 Ets-domain SAM_PNT PF02198.16 EMC90376.1 - 2.9e-34 116.9 1.1 5.9e-34 115.9 1.1 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Ets PF00178.22 EMC90377.1 - 2.1e-36 124.3 0.4 3.9e-36 123.4 0.4 1.5 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.16 EMC90377.1 - 2.2e-26 91.7 0.0 4.4e-26 90.7 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_2 PF07647.17 EMC90377.1 - 0.0077 16.3 0.1 0.082 13.0 0.1 2.3 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_3 PF18016.1 EMC90377.1 - 0.019 14.8 0.0 0.045 13.6 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EMC90377.1 - 0.083 13.4 0.2 0.22 12.0 0.2 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) IRK_C PF17655.1 EMC90378.1 - 1e-72 243.4 0.0 1.4e-72 242.9 0.0 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 EMC90378.1 - 3.2e-58 195.6 3.5 4.8e-58 195.0 3.5 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 EMC90378.1 - 0.12 12.3 10.7 0.53 10.3 10.7 2.1 1 1 0 1 1 1 0 Ion channel Pkinase PF00069.25 EMC90379.1 - 7e-50 169.8 0.0 1.1e-49 169.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC90379.1 - 5.6e-22 78.3 0.0 9.4e-22 77.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PIG-P PF08510.12 EMC90380.1 - 4.2e-38 130.0 1.8 4.8e-38 129.8 1.8 1.0 1 0 0 1 1 1 1 PIG-P Phage_holin_3_6 PF07332.11 EMC90380.1 - 0.023 14.7 0.8 0.031 14.3 0.8 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III AgrB PF04647.15 EMC90380.1 - 0.19 11.0 3.2 3.8 6.8 1.4 2.0 1 1 1 2 2 2 0 Accessory gene regulator B DPM2 PF07297.12 EMC90380.1 - 1.3 9.4 11.6 4.3 7.7 11.6 1.8 1 1 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) Ripply PF14998.6 EMC90381.1 - 3.8e-23 81.9 0.0 4.2e-23 81.8 0.0 1.0 1 0 0 1 1 1 1 Transcription Regulator BPL_LplA_LipB PF03099.19 EMC90382.1 - 4.9e-25 87.9 0.0 8.9e-25 87.1 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_N PF09825.9 EMC90382.1 - 7.2e-15 55.0 2.9 7.8e-08 31.8 0.1 2.9 2 1 1 3 3 3 2 Biotin-protein ligase, N terminal BPL_C PF02237.17 EMC90382.1 - 1.5e-08 34.4 0.0 3.4e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain ABC_transp_aux PF09822.9 EMC90382.1 - 0.00056 19.5 0.1 0.0011 18.6 0.1 1.5 1 0 0 1 1 1 1 ABC-type uncharacterized transport system SIM_C PF06621.12 EMC90383.1 - 8.2e-72 242.7 15.2 1.1e-71 242.3 15.2 1.1 1 0 0 1 1 1 1 Single-minded protein C-terminus PAS_3 PF08447.12 EMC90383.1 - 2.3e-24 85.5 0.7 1.5e-18 66.9 0.1 2.8 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 EMC90383.1 - 7e-19 68.0 0.4 1.3e-13 51.1 0.1 2.6 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 EMC90383.1 - 5.2e-17 61.9 0.0 1.1e-11 44.7 0.0 2.6 2 0 0 2 2 2 2 PAS fold HLH PF00010.26 EMC90383.1 - 0.00013 21.8 0.8 0.00038 20.4 0.6 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.7 EMC90383.1 - 0.00042 20.5 0.0 0.066 13.5 0.0 2.7 3 0 0 3 3 3 1 PAS domain PAS_4 PF08448.10 EMC90383.1 - 0.0034 17.6 0.0 0.049 13.9 0.0 2.4 2 0 0 2 2 2 1 PAS fold PMP22_Claudin PF00822.20 EMC90384.1 - 3.4e-32 111.6 11.8 4.1e-32 111.3 11.8 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC90384.1 - 1.6e-08 34.5 15.4 3.4e-07 30.2 15.4 2.0 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Amastin PF07344.11 EMC90384.1 - 0.19 11.6 11.8 0.31 10.9 11.3 1.8 1 1 1 2 2 2 0 Amastin surface glycoprotein DUF4064 PF13273.6 EMC90384.1 - 0.64 10.3 9.0 2.9e+02 1.8 0.0 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) DUF872 PF05915.12 EMC90384.1 - 0.92 9.7 3.1 1.4 9.1 0.7 2.4 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) YtpI PF14007.6 EMC90384.1 - 2.1 8.5 5.7 0.7 10.1 0.7 2.5 2 1 1 3 3 3 0 YtpI-like protein CAF-1_p60_C PF15512.6 EMC90385.1 - 5.5e-63 212.7 25.1 7.6e-63 212.2 25.1 1.2 1 0 0 1 1 1 1 Chromatin assembly factor complex 1 subunit p60, C-terminal WD40 PF00400.32 EMC90385.1 - 1.4e-23 82.7 12.8 1.4e-06 28.9 0.5 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC90385.1 - 5.5e-14 52.2 0.2 0.007 16.6 0.2 5.4 3 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 EMC90385.1 - 2e-05 23.8 0.1 0.0054 15.8 0.0 2.7 1 1 1 2 2 2 2 Coatomer WD associated region eIF2A PF08662.11 EMC90385.1 - 3.4e-05 23.8 0.7 0.0033 17.3 0.1 3.5 4 1 0 4 4 4 1 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.12 EMC90385.1 - 0.0017 16.5 0.5 0.092 10.7 0.1 2.2 2 0 0 2 2 2 2 IKI3 family Ge1_WD40 PF16529.5 EMC90385.1 - 0.0037 16.3 0.1 0.34 9.8 0.0 3.0 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EMC90385.1 - 2.2 8.3 7.1 8 6.5 1.2 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Morc6_S5 PF17942.1 EMC90386.1 - 4.2e-51 172.7 0.5 1.3e-50 171.0 0.5 1.9 1 0 0 1 1 1 1 Morc6 ribosomal protein S5 domain 2-like HATPase_c_3 PF13589.6 EMC90386.1 - 6.2e-19 68.2 1.6 6.6e-16 58.4 0.0 2.6 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase zf-CW PF07496.15 EMC90386.1 - 6.8e-17 61.2 3.5 2.5e-16 59.4 3.5 2.1 1 0 0 1 1 1 1 CW-type Zinc Finger HATPase_c PF02518.26 EMC90386.1 - 6.9e-06 26.5 0.0 1.7e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1664 PF07889.12 EMC90386.1 - 2.5 8.1 17.7 1.9 8.5 4.5 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) TMF_TATA_bd PF12325.8 EMC90386.1 - 2.8 8.2 34.0 0.31 11.3 14.9 4.4 1 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding THOC7 PF05615.13 EMC90386.1 - 3.5 7.9 24.5 0.17 12.2 7.6 3.0 2 1 0 2 2 2 0 Tho complex subunit 7 FlaC_arch PF05377.11 EMC90386.1 - 8.6 6.8 11.5 4.8 7.7 2.7 3.9 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Dopey_N PF04118.14 EMC90387.1 - 6.1e-97 324.4 2.1 1.9e-96 322.8 2.1 1.9 1 0 0 1 1 1 1 Dopey, N-terminal Phage_holin_4_1 PF05105.12 EMC90387.1 - 0.16 12.1 0.0 0.37 11.0 0.0 1.6 1 0 0 1 1 1 0 Bacteriophage holin family adh_short PF00106.25 EMC90388.1 - 5.7e-28 97.7 0.0 9.3e-27 93.8 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMC90388.1 - 3.5e-19 69.3 0.0 2e-17 63.5 0.0 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMC90388.1 - 1.3e-06 28.5 0.0 1.8e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.12 EMC90388.1 - 8.4e-05 21.9 0.1 0.00015 21.1 0.1 1.3 1 1 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 EMC90388.1 - 0.00029 20.4 0.0 0.00063 19.3 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family HATPase_c PF02518.26 EMC90388.1 - 0.004 17.6 0.0 0.12 12.9 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SET PF00856.28 EMC90389.1 - 2.8e-13 50.6 0.0 4.6e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 SET domain Rubis-subs-bind PF09273.11 EMC90389.1 - 3.1e-11 44.1 0.4 5.2e-11 43.3 0.4 1.4 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding Dna2 PF08696.11 EMC90389.1 - 0.13 12.1 0.2 0.23 11.2 0.2 1.3 1 0 0 1 1 1 0 DNA replication factor Dna2 GST_C_2 PF13410.6 EMC90390.1 - 1.4e-07 31.4 0.0 2.9e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EMC90390.1 - 2.9e-05 24.3 0.0 6.5e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EMC90390.1 - 6.1e-05 23.4 0.0 0.00012 22.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EMC90390.1 - 0.0011 19.2 0.3 0.0056 16.9 0.1 2.3 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain EST1_DNA_bind PF10373.9 EMC90390.1 - 0.025 14.1 0.1 0.034 13.6 0.1 1.2 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain GST_C_3 PF14497.6 EMC90390.1 - 0.034 14.3 0.2 0.099 12.8 0.1 1.9 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Calcipressin PF04847.12 EMC90391.1 - 1.9e-60 203.8 1.1 2.3e-60 203.5 1.1 1.0 1 0 0 1 1 1 1 Calcipressin ISK_Channel PF02060.15 EMC90392.1 - 9.2e-55 183.6 0.2 1e-54 183.4 0.2 1.0 1 0 0 1 1 1 1 Slow voltage-gated potassium channel 7tm_6 PF02949.20 EMC90392.1 - 0.032 13.3 0.2 0.035 13.2 0.2 1.0 1 0 0 1 1 1 0 7tm Odorant receptor FAM165 PF14981.6 EMC90394.1 - 2.3e-27 94.5 5.9 3.2e-27 94.1 5.9 1.3 1 1 0 1 1 1 1 FAM165 family ISK_Channel PF02060.15 EMC90395.1 - 1.9e-16 59.9 0.2 2.3e-16 59.6 0.2 1.1 1 0 0 1 1 1 1 Slow voltage-gated potassium channel LRRC37AB_C PF14914.6 EMC90395.1 - 0.041 13.8 0.1 0.055 13.4 0.1 1.2 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain TMEM154 PF15102.6 EMC90395.1 - 0.067 13.1 0.0 0.081 12.8 0.0 1.1 1 0 0 1 1 1 0 TMEM154 protein family Ribosomal_S6 PF01250.17 EMC90396.1 - 9.1e-15 54.7 0.0 1.1e-14 54.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 OSCP PF00213.18 EMC90397.1 - 2.8e-46 157.8 0.4 3.2e-46 157.6 0.4 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit PH_13 PF16652.5 EMC90398.1 - 7.8e-74 246.7 0.1 7.8e-74 246.7 0.1 4.0 3 1 0 4 4 3 1 Pleckstrin homology domain SH3_9 PF14604.6 EMC90398.1 - 1.3e-68 226.6 6.7 2.8e-16 59.1 0.1 5.4 5 0 0 5 5 5 5 Variant SH3 domain SH3_1 PF00018.28 EMC90398.1 - 1.1e-63 210.6 14.1 1.1e-16 60.1 0.3 5.5 5 0 0 5 5 5 5 SH3 domain SH3_2 PF07653.17 EMC90398.1 - 3e-57 190.1 1.5 4.8e-14 51.8 0.0 5.6 5 0 0 5 5 5 5 Variant SH3 domain INTAP PF16617.5 EMC90398.1 - 5.4e-54 181.5 14.5 5.4e-54 181.5 14.5 2.3 3 0 0 3 3 2 1 Intersectin and clathrin adaptor AP2 binding region RhoGEF PF00621.20 EMC90398.1 - 6.6e-46 156.8 1.4 6.6e-46 156.8 1.4 3.2 3 1 0 3 3 1 1 RhoGEF domain EF-hand_4 PF12763.7 EMC90398.1 - 1.2e-30 105.5 0.0 7.2e-15 54.8 0.0 3.0 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand C2 PF00168.30 EMC90398.1 - 2.5e-21 75.9 0.0 6.4e-21 74.6 0.0 1.7 1 0 0 1 1 1 1 C2 domain EF-hand_1 PF00036.32 EMC90398.1 - 8.3e-09 34.4 0.0 0.0029 17.0 0.0 3.5 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EMC90398.1 - 6.6e-07 28.8 0.2 0.39 10.8 0.0 4.0 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 EMC90398.1 - 6e-06 26.6 0.0 0.0059 17.0 0.0 3.3 2 0 0 2 2 2 1 EF-hand domain pair PH PF00169.29 EMC90398.1 - 0.00082 19.8 0.0 0.0024 18.3 0.0 1.8 1 0 0 1 1 1 1 PH domain EF-hand_5 PF13202.6 EMC90398.1 - 0.0035 16.8 0.2 0.63 9.6 0.0 2.8 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 EMC90398.1 - 0.065 13.1 0.0 1.2 9.0 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain pair GSH_synthase PF03199.15 EMC90398.1 - 0.099 13.1 2.2 0.34 11.4 0.3 3.1 2 1 0 2 2 2 0 Eukaryotic glutathione synthase G-patch PF01585.23 EMC90400.1 - 2.3e-17 62.6 3.0 5.2e-17 61.5 3.0 1.6 1 0 0 1 1 1 1 G-patch domain dsrm PF00035.26 EMC90400.1 - 8.2e-15 55.3 0.0 2.5e-14 53.7 0.0 1.9 1 0 0 1 1 1 1 Double-stranded RNA binding motif DND1_DSRM PF14709.7 EMC90400.1 - 6.8e-12 45.5 0.0 2.4e-11 43.7 0.0 2.0 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 G-patch_2 PF12656.7 EMC90400.1 - 2.5e-07 30.7 1.0 8.4e-07 29.0 1.0 1.9 1 0 0 1 1 1 1 G-patch domain RSRP PF17069.5 EMC90400.1 - 0.00024 20.8 0.7 0.00046 19.8 0.7 1.4 1 0 0 1 1 1 1 Arginine/Serine-Rich protein 1 GARS_A PF01071.19 EMC90401.1 - 2.7e-91 304.6 0.0 4.9e-91 303.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Formyl_trans_N PF00551.19 EMC90401.1 - 1.2e-66 223.9 0.1 2.8e-66 222.7 0.1 1.7 1 0 0 1 1 1 1 Formyl transferase AIRS_C PF02769.22 EMC90401.1 - 1.7e-39 135.4 0.4 9e-39 133.1 0.0 2.5 3 0 0 3 3 3 1 AIR synthase related protein, C-terminal domain GARS_N PF02844.15 EMC90401.1 - 3.7e-37 127.0 1.1 1.9e-35 121.5 0.1 3.3 3 0 0 3 3 2 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 EMC90401.1 - 3.4e-29 100.9 1.4 1.8e-28 98.6 0.4 2.7 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 EMC90401.1 - 1.9e-17 63.7 0.7 1e-16 61.4 0.7 2.3 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain ATP-grasp_3 PF02655.14 EMC90401.1 - 0.00019 21.5 0.0 0.0005 20.1 0.0 1.8 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.22 EMC90401.1 - 0.00086 18.9 0.1 0.0021 17.6 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_4 PF13535.6 EMC90401.1 - 0.0031 17.1 0.8 0.0069 16.0 0.1 1.9 2 0 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.17 EMC90401.1 - 0.0036 16.8 0.3 0.011 15.3 0.1 1.9 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_2 PF08442.10 EMC90401.1 - 0.028 14.0 0.0 0.076 12.6 0.0 1.7 1 0 0 1 1 1 0 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EMC90401.1 - 0.039 13.5 0.0 0.07 12.7 0.0 1.4 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus DUF1992 PF09350.10 EMC90402.1 - 7.2e-23 80.5 0.1 1.8e-22 79.2 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) DnaJ PF00226.31 EMC90402.1 - 3.7e-15 55.8 0.7 1.3e-14 54.1 0.7 2.0 1 0 0 1 1 1 1 DnaJ domain DUF3597 PF12200.8 EMC90402.1 - 0.043 14.3 0.3 0.091 13.3 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) UPF0220 PF05255.11 EMC90403.1 - 6.3e-51 172.2 4.6 7e-51 172.1 4.6 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) DUF1218 PF06749.12 EMC90403.1 - 6.3 7.4 7.8 1.2 9.7 1.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1218) Tissue_fac PF01108.17 EMC90404.1 - 4.9e-21 74.6 0.2 8.1e-21 73.9 0.2 1.4 1 0 0 1 1 1 1 Tissue factor Interfer-bind PF09294.10 EMC90404.1 - 1.4e-15 57.5 0.2 2.6e-15 56.6 0.2 1.5 1 1 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.21 EMC90404.1 - 5.5e-08 33.1 0.5 9e-07 29.2 0.1 2.2 2 0 0 2 2 2 1 Fibronectin type III domain Interfer-bind PF09294.10 EMC90405.1 - 1.8e-43 147.1 6.5 2.1e-22 79.4 0.9 3.4 4 0 0 4 4 4 2 Interferon-alpha/beta receptor, fibronectin type III Tissue_fac PF01108.17 EMC90405.1 - 2.2e-29 101.5 16.4 2.5e-15 56.2 0.9 3.6 3 0 0 3 3 3 2 Tissue factor fn3 PF00041.21 EMC90405.1 - 2.1e-08 34.4 17.4 1.8e-06 28.2 0.3 4.9 4 3 0 4 4 4 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 EMC90405.1 - 0.0001 22.8 4.0 0.51 11.0 0.2 3.8 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain fn3_4 PF16794.5 EMC90405.1 - 0.23 11.4 2.9 0.58 10.1 0.1 2.8 3 0 0 3 3 3 0 Fibronectin-III type domain Interfer-bind PF09294.10 EMC90406.1 - 1.8e-27 95.7 0.0 3.2e-27 94.9 0.0 1.4 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.21 EMC90406.1 - 0.0003 21.1 0.1 0.00093 19.5 0.2 1.8 2 0 0 2 2 2 1 Fibronectin type III domain Interfer-bind PF09294.10 EMC90407.1 - 1.2e-17 64.2 0.1 1.6e-17 63.7 0.1 1.1 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III HLH PF00010.26 EMC90408.1 - 4.9e-11 42.4 0.5 4.9e-11 42.4 0.5 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DUF4571 PF15137.6 EMC90409.1 - 3.8e-105 350.3 6.3 4.3e-105 350.2 6.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4571) Syja_N PF02383.18 EMC90410.1 - 1e-69 235.3 0.1 1.7e-69 234.6 0.1 1.4 1 0 0 1 1 1 1 SacI homology domain DUF1866 PF08952.11 EMC90410.1 - 1.4e-57 193.6 0.6 5e-55 185.4 0.2 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF1866) Exo_endo_phos PF03372.23 EMC90410.1 - 5.2e-16 58.9 0.1 1.1e-15 57.7 0.1 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF2870 PF11069.8 EMC90411.1 - 1.8e-30 105.2 1.9 1.8e-30 105.2 1.9 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2870) ubiquitin PF00240.23 EMC90411.1 - 0.024 14.4 2.9 0.12 12.2 0.0 2.8 3 0 0 3 3 3 0 Ubiquitin family FAM176 PF14851.6 EMC90412.1 - 2.7e-53 179.6 0.1 3.9e-53 179.0 0.1 1.3 1 0 0 1 1 1 1 FAM176 family Gal_Lectin PF02140.18 EMC90412.1 - 2.2e-34 117.7 6.2 7.4e-18 64.8 0.8 2.4 2 0 0 2 2 2 2 Galactose binding lectin domain Npa1 PF11707.8 EMC90413.1 - 4.5e-89 299.1 9.4 8.4e-88 295.0 0.2 4.0 3 0 0 3 3 3 2 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 EMC90413.1 - 9.7e-59 198.3 5.9 2e-58 197.3 1.1 4.0 2 1 0 2 2 2 1 Nucleolar pre-ribosomal-associated protein 1 Peptidase_C21 PF05381.12 EMC90413.1 - 0.16 12.3 0.4 4.7 7.6 0.1 3.0 2 0 0 2 2 2 0 Tymovirus endopeptidase PPL5 PF18168.1 EMC90414.1 - 1.4 8.1 5.1 6.9 5.9 5.7 1.7 2 0 0 2 2 2 0 Prim-pol family 5 Connexin PF00029.19 EMC90414.1 - 3.2 7.5 4.5 4.9 6.8 4.5 1.3 1 0 0 1 1 1 0 Connexin NARP1 PF12569.8 EMC90414.1 - 4 6.2 9.4 5.3 5.8 9.4 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Afi1 PF07792.12 EMC90414.1 - 9.2 6.8 6.1 24 5.4 6.1 1.8 1 1 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Yippee-Mis18 PF03226.14 EMC90415.1 - 4e-15 55.9 0.5 4.2e-15 55.9 0.5 1.0 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Pkinase PF00069.25 EMC90416.1 - 8e-64 215.5 0.0 1.2e-63 215.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC90416.1 - 6.4e-35 120.7 0.0 9.7e-35 120.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMC90416.1 - 3.4e-12 46.3 0.0 5.9e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC90416.1 - 1.4e-06 27.8 0.2 2.9e-06 26.8 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EMC90416.1 - 6.1e-05 22.7 0.8 0.00017 21.3 0.4 1.8 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 EMC90416.1 - 9.4e-05 22.4 0.0 0.0002 21.4 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EMC90416.1 - 0.0035 16.3 0.2 0.007 15.3 0.2 1.5 1 0 0 1 1 1 1 Haspin like kinase domain tRNA_bind_2 PF13725.6 EMC90416.1 - 0.02 14.6 0.3 0.24 11.1 0.1 2.3 2 0 0 2 2 2 0 Possible tRNA binding domain Pkinase_fungal PF17667.1 EMC90416.1 - 0.028 13.2 0.0 0.048 12.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase CTD_bind PF04818.13 EMC90417.1 - 1.7e-17 64.0 0.0 6.1e-17 62.2 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_1 PF00076.22 EMC90417.1 - 3.7e-09 36.3 0.0 1.1e-08 34.8 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMC90417.1 - 0.025 14.4 0.0 0.05 13.5 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif Sod_Cu PF00080.20 EMC90418.1 - 1.8e-45 154.6 5.6 2.2e-45 154.3 5.6 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) PMP22_Claudin PF00822.20 EMC90419.1 - 2.9e-27 95.6 8.4 3.6e-27 95.3 8.4 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC90419.1 - 1.3e-09 38.1 10.6 3.1e-09 36.9 10.6 1.6 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Clc-like PF07062.12 EMC90419.1 - 0.0052 16.3 6.7 0.12 11.8 0.2 2.2 2 0 0 2 2 2 2 Clc-like PMP22_Claudin PF00822.20 EMC90420.1 - 3.9e-29 101.7 8.3 4.5e-29 101.4 8.3 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 EMC90420.1 - 2.9e-11 43.5 7.6 6.2e-10 39.1 7.6 2.0 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction GSG-1 PF07803.11 EMC90420.1 - 0.034 14.1 0.8 7 6.6 0.1 3.0 3 0 0 3 3 3 0 GSG1-like protein DUF3169 PF11368.8 EMC90420.1 - 0.036 13.6 0.9 0.036 13.6 0.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) DUF2628 PF10947.8 EMC90420.1 - 0.36 11.2 5.9 0.11 12.9 1.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2628) Saf_2TM PF18303.1 EMC90420.1 - 1.1 8.8 4.6 4.8 6.8 4.6 2.0 1 1 0 1 1 1 0 SAVED-fused 2TM effector domain Clc-like PF07062.12 EMC90420.1 - 1.7 8.1 10.1 0.14 11.6 0.5 2.5 2 1 0 2 2 2 0 Clc-like SUR7 PF06687.12 EMC90420.1 - 1.8 8.1 12.0 0.04 13.6 4.6 1.9 1 1 0 2 2 2 0 SUR7/PalI family DUF4064 PF13273.6 EMC90420.1 - 5.5 7.3 15.1 0.95 9.8 9.7 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) ANF_receptor PF01094.28 EMC90421.1 - 2.5e-74 250.5 0.0 3.7e-74 250.0 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.26 EMC90421.1 - 8.2e-54 181.5 0.1 1.3e-53 180.8 0.1 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 EMC90421.1 - 1.4e-46 157.4 0.0 5.1e-46 155.6 0.0 2.0 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 EMC90421.1 - 2.6e-19 69.5 0.0 6.3e-19 68.3 0.0 1.6 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.6 EMC90421.1 - 4.2e-07 30.0 0.0 8.1e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein BTB PF00651.31 EMC90422.1 - 1.6e-24 86.3 0.5 3.7e-24 85.1 0.5 1.6 1 0 0 1 1 1 1 BTB/POZ domain bZIP_Maf PF03131.17 EMC90422.1 - 7.8e-16 58.4 5.6 2.2e-15 56.9 5.6 1.8 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.21 EMC90422.1 - 1.2e-09 38.1 8.1 2.9e-09 36.9 8.1 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMC90422.1 - 6.6e-07 29.3 9.1 1.6e-06 28.1 9.1 1.6 1 0 0 1 1 1 1 Basic region leucine zipper Mak16 PF04874.14 EMC90422.1 - 3.9 8.1 0.0 3.9 8.1 0.0 3.6 4 0 0 4 4 4 0 Mak16 protein C-terminal region APG6_N PF17675.1 EMC90423.1 - 0.00085 19.9 10.1 0.0012 19.4 10.1 1.2 1 0 0 1 1 1 1 Apg6 coiled-coil region FTA4 PF13093.6 EMC90423.1 - 0.021 14.7 3.7 0.024 14.5 3.7 1.1 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 GAS PF13851.6 EMC90423.1 - 0.035 13.5 13.8 0.044 13.1 13.8 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding KIX PF02172.16 EMC90423.1 - 0.071 13.4 2.5 0.12 12.7 2.1 1.6 1 1 0 1 1 1 0 KIX domain GIT_CC PF16559.5 EMC90423.1 - 0.094 12.6 3.3 0.17 11.8 3.3 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor CENP-H PF05837.12 EMC90423.1 - 0.16 12.4 13.2 2.9 8.3 13.0 2.0 1 1 0 1 1 1 0 Centromere protein H (CENP-H) Spc24 PF08286.11 EMC90423.1 - 0.18 12.0 10.5 0.42 10.9 6.3 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 CCDC-167 PF15188.6 EMC90423.1 - 0.22 11.9 11.6 0.36 11.2 11.6 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 SLATT_5 PF18160.1 EMC90423.1 - 0.29 10.4 4.8 0.41 10.0 4.8 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 DASH_Spc19 PF08287.11 EMC90423.1 - 0.33 10.8 10.2 0.43 10.5 10.2 1.1 1 0 0 1 1 1 0 Spc19 SKA2 PF16740.5 EMC90423.1 - 0.58 10.0 9.7 8.8 6.2 9.7 2.1 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 2 Takusan PF04822.13 EMC90423.1 - 0.71 9.8 8.7 1.2 9.1 8.7 1.4 1 0 0 1 1 1 0 Takusan Seryl_tRNA_N PF02403.22 EMC90423.1 - 2.2 8.5 10.1 3.3 8.0 10.1 1.2 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain bZIP_2 PF07716.15 EMC90423.1 - 2.4 8.3 14.6 2.2 8.4 2.3 2.3 2 0 0 2 2 2 0 Basic region leucine zipper ZapB PF06005.12 EMC90423.1 - 3 8.3 17.3 1.4 9.4 5.2 2.2 1 1 1 2 2 2 0 Cell division protein ZapB YabA PF06156.13 EMC90423.1 - 3.8 8.2 9.9 40 4.9 9.9 2.1 1 1 0 1 1 1 0 Initiation control protein YabA bZIP_1 PF00170.21 EMC90423.1 - 4.4 7.5 13.3 3.3 7.9 4.6 2.3 1 1 1 2 2 2 0 bZIP transcription factor UPF0242 PF06785.11 EMC90423.1 - 5 7.2 15.2 8.9 6.4 15.2 1.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Cpn60_TCP1 PF00118.24 EMC90424.1 - 7.6e-154 513.0 7.3 8.6e-154 512.8 7.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family UCH PF00443.29 EMC90425.1 - 2.2e-52 178.1 0.3 5.5e-52 176.8 0.3 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EMC90425.1 - 1.8e-21 76.2 7.4 6.7e-21 74.4 7.4 2.0 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein MMR_HSR1 PF01926.23 EMC90425.1 - 0.0058 16.7 0.4 0.096 12.8 0.0 2.9 3 1 0 3 3 3 1 50S ribosome-binding GTPase zinc_ribbon_10 PF10058.9 EMC90425.1 - 2.6 7.8 7.2 1.4 8.7 0.6 3.2 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein DUF1115 PF06544.12 EMC90426.1 - 9e-18 64.8 0.1 4e-17 62.7 0.1 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1115) RWD PF05773.22 EMC90426.1 - 5e-15 55.8 0.9 8.5e-15 55.1 0.9 1.4 1 0 0 1 1 1 1 RWD domain MTS PF05175.14 EMC90427.1 - 1.2e-07 31.5 0.0 1.6e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EMC90427.1 - 2.2e-05 24.0 0.0 3.7e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EMC90427.1 - 0.0002 22.0 0.0 0.00046 20.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMC90427.1 - 0.0047 17.7 0.0 0.0078 16.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMC90427.1 - 0.055 13.3 0.0 0.12 12.2 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.6 EMC90427.1 - 0.08 14.0 0.0 0.14 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain ADAM_spacer1 PF05986.14 EMC90428.1 - 1.8e-33 115.0 0.1 2.9e-33 114.3 0.1 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 ADAM_CR_2 PF17771.1 EMC90428.1 - 1e-21 77.2 15.0 1.5e-20 73.5 5.9 5.2 5 1 1 6 6 6 2 ADAM cysteine-rich domain Reprolysin PF01421.19 EMC90428.1 - 1.2e-20 74.3 0.3 2.5e-20 73.3 0.3 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_3 PF13582.6 EMC90428.1 - 1.3e-12 48.3 1.0 3.2e-12 47.0 1.0 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like TSP_1 PF00090.19 EMC90428.1 - 4e-10 39.8 5.4 4e-10 39.8 5.4 4.3 4 0 0 4 4 4 2 Thrombospondin type 1 domain Reprolysin_5 PF13688.6 EMC90428.1 - 6.3e-10 39.5 1.0 1.3e-09 38.5 1.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 EMC90428.1 - 2.9e-06 27.3 0.5 7.5e-06 26.0 0.5 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EMC90428.1 - 6.3e-06 26.0 0.5 1.2e-05 25.1 0.5 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 EMC90428.1 - 0.0013 18.5 0.4 0.0029 17.5 0.4 1.5 1 0 0 1 1 1 1 Matrixin CxC6 PF18721.1 EMC90428.1 - 0.0049 17.1 3.5 0.0049 17.1 3.5 3.3 2 0 0 2 2 2 1 CxC6 like cysteine cluster associated with KDZ transposases Astacin PF01400.24 EMC90428.1 - 0.018 14.7 0.0 0.039 13.6 0.0 1.5 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) DUF3285 PF11688.8 EMC90428.1 - 0.039 13.9 0.0 0.078 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3285) DUF4953 PF16313.5 EMC90428.1 - 0.061 12.5 0.5 0.13 11.5 0.5 1.4 1 0 0 1 1 1 0 Met-zincin Peptidase_M54 PF07998.11 EMC90428.1 - 0.085 12.8 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 Peptidase family M54 Atracotoxin PF05353.11 EMC90429.1 - 2.9 8.0 16.6 0.09 12.8 10.4 1.8 2 0 0 2 2 2 0 Delta Atracotoxin ADAM_spacer1 PF05986.14 EMC90430.1 - 1.8e-32 111.8 0.0 2.9e-32 111.1 0.0 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 ADAM_CR_2 PF17771.1 EMC90430.1 - 2.2e-23 82.6 18.8 1.2e-22 80.2 9.7 4.3 4 1 0 4 4 4 2 ADAM cysteine-rich domain Reprolysin PF01421.19 EMC90430.1 - 9.6e-20 71.3 0.0 1.5e-19 70.7 0.0 1.3 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease TSP_1 PF00090.19 EMC90430.1 - 4e-13 49.3 54.4 6.1e-09 36.0 6.6 6.1 6 0 0 6 6 6 3 Thrombospondin type 1 domain Reprolysin_5 PF13688.6 EMC90430.1 - 1.1e-12 48.5 0.2 2.2e-12 47.5 0.2 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EMC90430.1 - 3.4e-11 43.7 0.0 6.6e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EMC90430.1 - 0.00034 20.6 0.0 0.00069 19.6 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EMC90430.1 - 0.00035 20.3 0.0 0.00058 19.6 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like CxC6 PF18721.1 EMC90430.1 - 0.012 15.9 3.1 0.012 15.9 3.1 4.1 5 0 0 5 5 5 0 CxC6 like cysteine cluster associated with KDZ transposases CYYR1 PF10873.8 EMC90431.1 - 1.1e-74 249.9 20.4 1.2e-74 249.8 20.4 1.0 1 0 0 1 1 1 1 Cysteine and tyrosine-rich protein 1 WBP-1 PF11669.8 EMC90431.1 - 0.00016 22.2 4.7 0.00027 21.5 4.7 1.3 1 0 0 1 1 1 1 WW domain-binding protein 1 Shisa PF13908.6 EMC90431.1 - 0.038 14.2 0.1 0.038 14.2 0.1 2.2 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Podoplanin PF05808.11 EMC90431.1 - 2.8 8.0 5.4 4.1 7.5 5.4 1.1 1 0 0 1 1 1 0 Podoplanin Ets PF00178.22 EMC90432.1 - 9.4e-34 115.7 0.3 2e-33 114.7 0.3 1.6 1 0 0 1 1 1 1 Ets-domain GABP-alpha PF11620.8 EMC90432.1 - 4.5e-32 110.1 0.8 1.3e-31 108.6 0.8 1.8 2 0 0 2 2 2 1 GA-binding protein alpha chain SAM_PNT PF02198.16 EMC90432.1 - 2.1e-28 98.1 0.2 6.3e-28 96.6 0.2 1.9 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Syntaxin-18_N PF10496.9 EMC90432.1 - 0.17 12.2 0.0 0.4 11.0 0.0 1.6 1 0 0 1 1 1 0 SNARE-complex protein Syntaxin-18 N-terminus ATP-synt_F6 PF05511.11 EMC90433.1 - 1.4e-43 147.2 0.1 1.6e-43 147.1 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial ATP synthase coupling factor 6 Ig_3 PF13927.6 EMC90434.1 - 3.7e-21 75.5 1.6 2.2e-13 50.6 0.7 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 EMC90434.1 - 7.7e-18 64.5 1.7 4.2e-09 36.5 0.4 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC90434.1 - 1.2e-17 63.7 0.9 1.3e-09 38.0 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 EMC90434.1 - 5.3e-16 58.8 1.9 2.7e-08 34.0 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin V-set domain Ig_2 PF13895.6 EMC90434.1 - 2.7e-13 50.1 1.4 4.4e-09 36.6 0.7 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_6 PF18452.1 EMC90434.1 - 4.3e-06 26.2 0.1 0.0025 17.4 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Izumo-Ig PF16706.5 EMC90434.1 - 1.4e-05 25.1 0.7 0.019 15.0 0.1 3.1 2 1 0 2 2 2 2 Izumo-like Immunoglobulin domain Ig_C17orf99 PF17736.1 EMC90434.1 - 1.5e-05 24.9 0.0 0.00018 21.5 0.0 2.5 2 1 0 2 2 2 1 C17orf99 Ig domain C2-set_2 PF08205.12 EMC90434.1 - 0.0032 17.5 0.2 0.008 16.2 0.2 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.5 EMC90434.1 - 0.0062 16.8 1.6 11 6.3 0.0 3.6 3 1 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Receptor_2B4 PF11465.8 EMC90434.1 - 0.016 15.4 0.2 7.3 6.9 0.0 2.8 2 1 0 2 2 2 0 Natural killer cell receptor 2B4 DUF4307 PF14155.6 EMC90434.1 - 0.23 11.3 6.4 0.2 11.5 0.3 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4307) TGS PF02824.21 EMC90435.1 - 0.00036 20.5 0.0 0.00074 19.5 0.0 1.5 1 0 0 1 1 1 1 TGS domain DUF2469 PF10611.9 EMC90435.1 - 0.0029 18.1 0.0 0.0087 16.6 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2469) tRNA_SAD PF07973.14 EMC90435.1 - 0.049 13.7 0.0 0.095 12.8 0.0 1.4 1 0 0 1 1 1 0 Threonyl and Alanyl tRNA synthetase second additional domain I-set PF07679.16 EMC90437.1 - 1.1e-82 272.2 0.5 1.8e-19 69.5 0.2 5.7 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC90437.1 - 8.8e-68 224.9 7.3 4.9e-16 59.1 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 EMC90437.1 - 6.9e-48 160.8 1.1 2.7e-10 40.3 0.0 5.4 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.6 EMC90437.1 - 1.1e-45 153.8 0.8 1.1e-08 35.3 0.0 5.4 5 0 0 5 5 5 5 Immunoglobulin domain fn3 PF00041.21 EMC90437.1 - 1.5e-29 102.2 1.9 1.8e-16 60.2 0.6 2.8 2 0 0 2 2 2 2 Fibronectin type III domain V-set PF07686.17 EMC90437.1 - 3.3e-26 91.6 2.8 1.2e-05 25.4 0.0 8.3 4 3 1 5 5 5 4 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC90437.1 - 1.8e-12 47.2 1.5 0.0015 18.6 0.0 5.1 5 0 0 5 5 5 4 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 EMC90437.1 - 1.3e-11 44.4 0.1 0.016 15.2 0.0 4.9 5 0 0 5 5 5 2 Izumo-like Immunoglobulin domain Ig_C17orf99 PF17736.1 EMC90437.1 - 6.3e-11 42.2 0.0 0.059 13.4 0.0 5.5 5 0 0 5 5 5 2 C17orf99 Ig domain Ig_5 PF16681.5 EMC90437.1 - 4.2e-10 39.9 0.1 0.022 15.1 0.0 5.1 5 0 0 5 5 5 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 EMC90437.1 - 6.5e-09 35.2 0.0 1 9.0 0.0 5.4 5 0 0 5 5 5 2 Immunoglobulin domain Ig_4 PF16680.5 EMC90437.1 - 8.3e-09 35.6 1.0 0.48 10.7 0.0 6.0 5 1 0 5 5 5 2 T-cell surface glycoprotein CD3 delta chain Receptor_2B4 PF11465.8 EMC90437.1 - 6.2e-06 26.4 0.6 8.8 6.6 0.0 5.1 5 1 0 5 5 5 1 Natural killer cell receptor 2B4 Adeno_E3_CR1 PF02440.15 EMC90437.1 - 2e-05 24.3 0.0 0.35 10.7 0.0 4.0 4 0 0 4 4 4 1 Adenovirus E3 region protein CR1 Herpes_gE PF02480.16 EMC90437.1 - 0.00013 20.9 0.1 0.16 10.7 0.1 3.3 1 1 2 3 3 3 1 Alphaherpesvirus glycoprotein E Pur_ac_phosph_N PF16656.5 EMC90437.1 - 0.00046 20.7 1.8 0.0024 18.4 0.9 2.8 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 EMC90437.1 - 0.011 16.0 0.0 2.4 8.5 0.0 3.1 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III C2-set PF05790.15 EMC90437.1 - 0.035 14.3 0.2 5.7 7.2 0.0 4.2 5 0 0 5 5 4 0 Immunoglobulin C2-set domain ig PF00047.25 EMC90440.1 - 8.7e-16 57.9 2.1 7.9e-08 32.4 1.1 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 EMC90440.1 - 3.1e-14 53.1 1.8 2.6e-09 37.3 0.8 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 EMC90440.1 - 1.1e-13 51.6 2.7 6.2e-09 36.3 0.7 2.2 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC90440.1 - 4.7e-13 49.0 0.6 2.2e-08 34.1 0.2 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 EMC90440.1 - 5.1e-12 45.9 9.1 1.3e-08 35.0 0.0 3.5 3 1 1 4 4 4 3 Immunoglobulin V-set domain Izumo-Ig PF16706.5 EMC90440.1 - 4.3e-06 26.7 0.0 0.087 12.9 0.0 2.2 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 EMC90440.1 - 4.7e-06 26.1 3.2 0.042 13.4 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin domain Ig_5 PF16681.5 EMC90440.1 - 1.2e-05 25.6 2.4 0.0011 19.3 0.1 2.9 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Herpes_gE PF02480.16 EMC90440.1 - 0.00019 20.3 0.7 0.83 8.3 0.0 2.9 1 1 2 3 3 3 2 Alphaherpesvirus glycoprotein E Adeno_E3_CR1 PF02440.15 EMC90440.1 - 0.00027 20.6 0.9 0.019 14.8 0.6 2.5 2 1 0 2 2 2 1 Adenovirus E3 region protein CR1 C2-set_2 PF08205.12 EMC90440.1 - 0.00088 19.3 0.3 0.0024 17.9 0.3 1.7 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain REJ PF02010.15 EMC90440.1 - 0.00095 18.1 0.7 0.63 8.8 0.0 2.4 1 1 1 2 2 2 2 REJ domain Ig_4 PF16680.5 EMC90440.1 - 0.002 18.3 4.9 0.02 15.1 0.2 2.6 3 0 0 3 3 2 1 T-cell surface glycoprotein CD3 delta chain CCSMST1 PF15013.6 EMC90440.1 - 0.02 15.0 0.0 0.035 14.3 0.0 1.4 1 0 0 1 1 1 0 CCSMST1 family stn_TNFRSF12A PF12191.8 EMC90440.1 - 0.075 13.2 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain Syndecan PF01034.20 EMC90440.1 - 0.082 12.8 0.8 0.17 11.9 0.8 1.4 1 0 0 1 1 1 0 Syndecan domain FAM163 PF15069.6 EMC90440.1 - 2.6 8.5 7.7 1.2 9.5 4.9 1.8 2 0 0 2 2 2 0 FAM163 family Maelstrom PF13017.6 EMC90441.1 - 3.1e-38 131.6 0.5 5.4e-38 130.8 0.5 1.4 1 0 0 1 1 1 1 piRNA pathway germ-plasm component HMG_box_2 PF09011.10 EMC90441.1 - 2.1e-16 60.2 0.2 4.3e-16 59.3 0.2 1.5 1 0 0 1 1 1 1 HMG-box domain HMG_box PF00505.19 EMC90441.1 - 0.011 16.2 0.0 0.028 14.8 0.0 1.7 1 0 0 1 1 1 0 HMG (high mobility group) box LSR PF05624.14 EMC90442.1 - 1.5e-24 85.7 33.5 2.3e-24 85.1 33.5 1.3 1 0 0 1 1 1 1 Lipolysis stimulated receptor (LSR) V-set PF07686.17 EMC90442.1 - 9.6e-06 25.7 0.1 0.0068 16.6 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin V-set domain Phage_r1t_holin PF16945.5 EMC90443.1 - 0.019 15.1 3.5 0.047 13.9 3.5 1.6 1 0 0 1 1 1 0 Putative lactococcus lactis phage r1t holin zf-H2C2_2 PF13465.6 EMC90444.1 - 3.8e-54 178.8 43.8 8.7e-09 35.4 1.1 9.3 9 0 0 9 9 9 7 Zinc-finger double domain zf-C2H2 PF00096.26 EMC90444.1 - 4.9e-49 162.1 58.4 1.7e-07 31.3 0.6 8.2 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC90444.1 - 6e-32 107.6 53.7 0.00043 20.9 2.7 8.2 8 0 0 8 8 8 8 C2H2-type zinc finger zf_UBZ PF18439.1 EMC90444.1 - 2.6e-11 42.9 31.2 0.068 12.8 0.1 8.3 8 0 0 8 8 8 3 Ubiquitin-Binding Zinc Finger zf-C2H2_jaz PF12171.8 EMC90444.1 - 3e-11 43.3 21.4 0.17 12.2 0.3 7.6 8 0 0 8 8 7 4 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 EMC90444.1 - 2.5e-10 40.3 33.5 0.0022 18.1 4.3 6.4 4 2 4 8 8 8 5 Zinc ribbon domain zf-C2H2_6 PF13912.6 EMC90444.1 - 3.6e-07 30.0 49.3 0.36 10.9 2.4 8.6 8 1 0 8 8 8 6 C2H2-type zinc finger XPA_N PF01286.18 EMC90444.1 - 5.6e-07 29.5 28.2 0.5 10.5 0.4 8.0 8 0 0 8 8 8 3 XPA protein N-terminal DZR PF12773.7 EMC90444.1 - 9.7e-07 28.7 31.1 1.8e+04 -9.4 31.1 5.3 1 1 0 1 1 0 0 Double zinc ribbon zinc_ribbon_15 PF17032.5 EMC90444.1 - 1.1e-06 29.3 22.3 0.16 12.7 0.5 4.8 1 1 6 7 7 7 5 zinc-ribbon family C1_1 PF00130.22 EMC90444.1 - 6.3e-06 26.0 28.1 0.12 12.3 0.7 6.5 1 1 7 8 8 8 4 Phorbol esters/diacylglycerol binding domain (C1 domain) ADK_lid PF05191.14 EMC90444.1 - 6.3e-05 22.9 19.1 1.9 8.5 0.2 6.1 2 2 4 6 6 6 1 Adenylate kinase, active site lid FYDLN_acid PF09538.10 EMC90444.1 - 0.00056 20.6 15.2 7.9 7.2 0.7 7.3 2 1 1 5 5 5 0 Protein of unknown function (FYDLN_acid) DNA_RNApol_7kD PF03604.13 EMC90444.1 - 0.00059 19.5 30.1 1.8 8.3 0.2 8.1 8 0 0 8 8 8 2 DNA directed RNA polymerase, 7 kDa subunit zf-trcl PF13451.6 EMC90444.1 - 0.00078 19.3 24.2 8.4 6.4 0.2 7.9 8 0 0 8 8 8 0 Probable zinc-ribbon domain zf-LYAR PF08790.11 EMC90444.1 - 0.00081 19.2 33.2 1.4 8.9 0.1 8.2 8 0 0 8 8 8 2 LYAR-type C2HC zinc finger zf-C2H2_11 PF16622.5 EMC90444.1 - 0.0054 16.5 3.2 0.045 13.5 0.2 8.0 8 0 0 8 8 8 3 zinc-finger C2H2-type zf-AN1 PF01428.16 EMC90444.1 - 0.014 15.5 40.4 2.8 8.2 4.2 8.3 5 2 3 8 8 8 0 AN1-like Zinc finger YhfH PF14149.6 EMC90444.1 - 0.016 15.2 28.8 6 6.9 0.1 7.9 8 0 0 8 8 8 0 YhfH-like protein CpXC PF14353.6 EMC90444.1 - 0.016 15.2 26.2 1.9 8.6 0.2 7.3 2 2 6 8 8 8 0 CpXC protein zf-C2HE PF16278.5 EMC90444.1 - 0.023 15.1 35.2 0.88 10.1 0.6 7.8 1 1 6 7 7 7 0 C2HE / C2H2 / C2HC zinc-binding finger zf-Di19 PF05605.12 EMC90444.1 - 0.035 14.4 28.5 0.039 14.2 0.1 5.4 1 1 4 7 7 7 0 Drought induced 19 protein (Di19), zinc-binding TFIIS_C PF01096.18 EMC90444.1 - 0.13 12.1 28.8 12 5.8 0.2 7.6 7 1 0 7 7 7 0 Transcription factor S-II (TFIIS) zf-met PF12874.7 EMC90444.1 - 0.21 12.0 46.4 0.19 12.2 1.8 7.9 8 0 0 8 8 8 0 Zinc-finger of C2H2 type zinc_ribbon_9 PF14369.6 EMC90444.1 - 0.25 11.7 30.0 6.9 7.0 0.2 7.7 7 1 1 8 8 8 0 zinc-ribbon DUF3268 PF11672.8 EMC90444.1 - 0.28 11.5 20.1 4.9 7.5 0.6 4.6 1 1 6 7 7 7 0 zinc-finger-containing domain OSTMP1 PF09777.9 EMC90444.1 - 0.29 10.5 7.2 0.75 9.2 6.1 2.1 1 1 1 2 2 2 0 Osteopetrosis-associated transmembrane protein 1 precursor Zn_ribbon_SprT PF17283.2 EMC90444.1 - 0.4 10.6 34.5 0.14 12.0 4.3 6.2 5 2 2 7 7 7 0 SprT-like zinc ribbon domain BolA PF01722.18 EMC90444.1 - 0.52 10.6 5.0 41 4.6 0.1 3.7 2 2 1 3 3 3 0 BolA-like protein Rpr2 PF04032.16 EMC90444.1 - 0.6 10.4 24.7 0.59 10.5 9.3 4.5 1 1 2 3 3 3 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-C2H2_3rep PF18868.1 EMC90444.1 - 0.81 10.4 22.3 1.7e+02 2.9 9.0 5.8 1 1 3 4 4 4 0 Zinc finger C2H2-type, 3 repeats C1_4 PF07975.12 EMC90444.1 - 0.82 10.0 27.9 0.94 9.8 1.0 5.4 1 1 5 6 6 6 0 TFIIH C1-like domain Zn-C2H2_12 PF18112.1 EMC90444.1 - 0.87 10.1 0.1 0.87 10.1 0.1 4.7 7 0 0 7 7 3 0 Autophagy receptor zinc finger-C2H2 domain LIM PF00412.22 EMC90444.1 - 0.91 9.8 29.9 2.2 8.6 0.7 6.0 1 1 6 7 7 7 0 LIM domain COX5B PF01215.19 EMC90444.1 - 2.5 7.8 11.3 1.9 8.2 0.2 4.2 2 1 2 5 5 5 0 Cytochrome c oxidase subunit Vb zinc-ribbons_6 PF07191.12 EMC90444.1 - 3.4 7.7 29.1 1.5e+03 -0.8 10.9 6.1 1 1 1 2 2 1 0 zinc-ribbons Zn_ribbon_recom PF13408.6 EMC90444.1 - 3.4 8.3 35.5 88 3.7 0.1 6.7 2 1 3 5 5 5 0 Recombinase zinc beta ribbon domain DUF2256 PF10013.9 EMC90444.1 - 4.5 7.5 20.2 46 4.2 0.1 7.1 8 0 0 8 8 7 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-RING_7 PF02591.15 EMC90444.1 - 6.1 7.1 20.6 19 5.5 0.1 6.7 7 0 0 7 7 7 0 C4-type zinc ribbon domain zf-HIT PF04438.16 EMC90444.1 - 7.4 6.5 36.3 4.3 7.3 0.3 7.5 8 0 0 8 8 8 0 HIT zinc finger PknG_rubred PF16919.5 EMC90444.1 - 8.7 6.5 33.9 0.46 10.6 3.3 5.3 1 1 3 5 5 5 0 Protein kinase G rubredoxin domain Ig_3 PF13927.6 EMC90445.1 - 0.00017 22.1 0.2 0.73 10.5 0.0 3.0 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC90445.1 - 0.0027 17.7 0.0 0.61 10.2 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.25 EMC90445.1 - 0.01 16.0 0.9 7 6.9 0.2 3.0 3 1 0 3 3 3 0 Immunoglobulin domain Ig_2 PF13895.6 EMC90445.1 - 0.044 14.1 0.3 0.86 10.0 0.1 2.9 2 1 1 3 3 3 0 Immunoglobulin domain Shisa PF13908.6 EMC90445.1 - 0.074 13.3 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator V-set PF07686.17 EMC90445.1 - 0.088 13.0 0.1 2 8.6 0.0 2.8 3 0 0 3 3 3 0 Immunoglobulin V-set domain Orthoreo_P10 PF07204.11 EMC90445.1 - 0.13 12.2 0.9 0.3 11.1 0.9 1.5 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 I-set PF07679.16 EMC90446.1 - 0.00012 22.1 0.2 0.00022 21.2 0.2 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain DUF1958 PF09211.10 EMC90446.1 - 0.0078 16.5 0.9 1.1 9.6 0.1 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF1958) Ig_3 PF13927.6 EMC90446.1 - 0.012 16.2 0.5 0.023 15.3 0.1 1.8 2 0 0 2 2 2 0 Immunoglobulin domain V-set PF07686.17 EMC90446.1 - 0.022 14.9 0.1 0.036 14.2 0.1 1.5 1 1 0 1 1 1 0 Immunoglobulin V-set domain V-set PF07686.17 EMC90447.1 - 1.6e-31 108.7 11.4 3.1e-07 30.5 0.1 6.2 6 0 0 6 6 6 5 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC90447.1 - 3.4e-29 101.2 12.3 1.6e-06 28.6 0.0 7.1 6 2 0 6 6 6 5 Immunoglobulin domain I-set PF07679.16 EMC90447.1 - 5e-21 74.6 3.4 0.00025 21.0 0.0 8.0 6 2 1 7 7 7 5 Immunoglobulin I-set domain ig PF00047.25 EMC90447.1 - 2.3e-18 66.2 13.7 0.00024 21.2 0.0 7.3 6 2 0 6 6 6 4 Immunoglobulin domain Ig_2 PF13895.6 EMC90447.1 - 3.7e-14 52.8 14.2 0.0057 17.0 0.2 8.4 6 4 0 6 6 6 3 Immunoglobulin domain Izumo-Ig PF16706.5 EMC90447.1 - 3.9e-05 23.6 0.1 1.4 9.0 0.0 5.1 5 0 0 5 5 5 1 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 EMC90447.1 - 8.8e-05 22.0 0.5 5.4 6.7 0.0 4.7 5 0 0 5 5 5 2 Immunoglobulin domain Ig_5 PF16681.5 EMC90447.1 - 0.0088 16.4 0.3 10 6.6 0.0 4.9 5 1 0 5 5 5 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set PF07686.17 EMC90448.1 - 1.6e-65 218.1 7.6 1.1e-11 44.9 0.0 7.2 7 0 0 7 7 7 7 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC90448.1 - 6.8e-53 177.2 2.0 6.1e-06 26.7 0.0 8.4 7 2 0 7 7 7 7 Immunoglobulin domain I-set PF07679.16 EMC90448.1 - 2.5e-38 130.0 0.7 5.7e-05 23.1 0.0 10.1 7 5 0 7 7 7 7 Immunoglobulin I-set domain ig PF00047.25 EMC90448.1 - 1.3e-29 102.2 1.6 0.00039 20.5 0.0 9.1 8 2 0 8 8 8 6 Immunoglobulin domain Ig_2 PF13895.6 EMC90448.1 - 3.1e-28 97.9 6.9 0.00055 20.2 0.0 11.6 8 6 0 8 8 8 7 Immunoglobulin domain Izumo-Ig PF16706.5 EMC90448.1 - 5.2e-11 42.4 1.1 0.11 12.5 0.0 7.1 7 1 0 7 7 7 2 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 EMC90448.1 - 3.3e-06 26.6 0.0 2.8 7.6 0.0 5.3 5 0 0 5 5 5 1 Immunoglobulin domain C2-set PF05790.15 EMC90448.1 - 0.028 14.6 4.6 3.5 7.9 0.0 5.2 5 0 0 5 5 5 0 Immunoglobulin C2-set domain Sushi PF00084.20 EMC90448.1 - 0.031 14.9 0.1 67 4.2 0.0 4.6 5 0 0 5 5 5 0 Sushi repeat (SCR repeat) V-set PF07686.17 EMC90449.1 - 2.4e-10 40.6 0.4 4.9e-10 39.5 0.4 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 EMC90449.1 - 4.8e-06 26.7 1.8 0.00031 20.9 0.2 2.5 2 0 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.12 EMC90449.1 - 8e-06 25.8 0.4 1.9e-05 24.7 0.4 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 EMC90449.1 - 1.4e-05 25.6 6.1 0.00027 21.4 0.2 3.2 2 1 1 3 3 3 1 Immunoglobulin domain I-set PF07679.16 EMC90449.1 - 0.00012 22.0 0.1 0.00042 20.3 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_6 PF18452.1 EMC90449.1 - 0.00062 19.3 0.6 0.0014 18.2 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain Tim17 PF02466.19 EMC90450.1 - 1.3e-07 32.0 1.0 1.9e-07 31.4 1.0 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Bacteriocin_IIc PF10439.9 EMC90450.1 - 0.2 11.8 5.1 0.34 11.1 5.1 1.4 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Glyco_transf_90 PF05686.12 EMC90451.1 - 1.3e-114 383.2 1.6 1.6e-114 382.9 1.6 1.0 1 0 0 1 1 1 1 Glycosyl transferase family 90 Potyvirid-P3 PF13608.6 EMC90451.1 - 0.042 12.9 0.0 0.071 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein P3 of Potyviral polyprotein Glyco_trans_1_2 PF13524.6 EMC90451.1 - 0.043 14.2 0.0 0.077 13.4 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 BCL9 PF11502.8 EMC90452.1 - 1.6e-20 72.6 2.0 6.1e-20 70.7 2.0 2.2 1 0 0 1 1 1 1 B-cell lymphoma 9 protein His_Phos_2 PF00328.22 EMC90453.1 - 4.3e-20 72.4 0.1 6.3e-19 68.6 0.1 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Connexin PF00029.19 EMC90454.1 - 4.5e-100 334.2 2.8 5.6e-100 333.9 2.8 1.1 1 0 0 1 1 1 1 Connexin Connexin40_C PF16791.5 EMC90454.1 - 7.7e-30 104.3 2.8 7.7e-30 104.3 2.8 2.0 2 0 0 2 2 2 1 Connexin 40 C-terminal domain Connexin PF00029.19 EMC90455.1 - 1e-100 336.3 0.2 1e-100 336.3 0.2 1.6 2 0 0 2 2 2 1 Connexin Connexin50 PF03509.14 EMC90455.1 - 6.8e-31 106.9 2.8 9.5e-31 106.4 0.4 2.4 2 0 0 2 2 2 1 Gap junction alpha-8 protein (Cx50) Connexin40_C PF16791.5 EMC90455.1 - 0.00012 23.3 0.0 0.00024 22.3 0.0 1.6 1 0 0 1 1 1 1 Connexin 40 C-terminal domain 7tm_1 PF00001.21 EMC90455.1 - 0.16 11.2 0.5 2.1 7.6 0.5 2.0 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) ABA_GPCR PF12430.8 EMC90456.1 - 3.1e-42 144.4 12.3 3.1e-42 144.4 12.3 2.2 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 EMC90456.1 - 7.5e-29 99.6 0.4 2e-28 98.2 0.1 2.0 2 0 0 2 2 2 1 The Golgi pH Regulator (GPHR) Family N-terminal NPCC PF08058.11 EMC90456.1 - 0.51 10.4 0.0 0.51 10.4 0.0 3.4 3 1 0 3 3 3 0 Nuclear pore complex component C2-set_2 PF08205.12 EMC90457.1 - 3.2e-08 33.5 1.7 3.2e-08 33.5 1.7 1.7 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 EMC90457.1 - 9e-08 32.3 0.5 4.2e-07 30.1 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.16 EMC90457.1 - 3.9e-07 30.0 0.1 0.00013 22.0 0.0 2.5 1 1 1 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 EMC90457.1 - 7.2e-05 22.9 5.1 0.0068 16.6 0.5 2.8 2 1 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 EMC90457.1 - 0.0002 21.9 6.1 0.26 11.9 0.2 2.9 2 2 1 3 3 3 2 Immunoglobulin domain Ig_6 PF18452.1 EMC90457.1 - 0.039 13.5 0.0 0.11 12.1 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin domain Ig_2 PF13895.6 EMC90457.1 - 0.05 13.9 5.5 1.4 9.3 0.6 2.7 1 1 1 2 2 2 0 Immunoglobulin domain Phage_TTP_12 PF16461.5 EMC90457.1 - 0.077 12.7 0.1 0.51 10.0 0.1 2.0 1 1 0 1 1 1 0 Lambda phage tail tube protein, TTP 7tm_1 PF00001.21 EMC90458.1 - 2e-76 256.8 8.7 2e-76 256.8 8.7 1.5 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC90458.1 - 7.4e-07 28.8 19.0 1.3e-06 28.0 17.0 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC90458.1 - 4.5e-05 23.2 14.3 4.5e-05 23.2 14.3 2.3 2 2 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx Pou PF00157.17 EMC90459.1 - 1e-34 118.3 3.3 7.9e-34 115.5 0.4 3.1 3 0 0 3 3 3 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 EMC90459.1 - 1e-17 63.7 3.5 1e-17 63.7 2.1 1.8 2 0 0 2 2 2 1 Homeodomain HTH_31 PF13560.6 EMC90459.1 - 0.059 13.7 0.0 4.3 7.8 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain Homeobox_KN PF05920.11 EMC90459.1 - 0.15 12.0 0.0 0.42 10.6 0.0 1.7 1 0 0 1 1 1 0 Homeobox KN domain Lsr2 PF11774.8 EMC90459.1 - 0.18 11.9 0.7 0.35 11.0 0.2 1.7 2 0 0 2 2 2 0 Lsr2 Snf7 PF03357.21 EMC90460.1 - 1.7e-43 148.2 28.8 1.7e-43 148.2 28.8 1.4 2 0 0 2 2 2 1 Snf7 DnaJ-X PF14308.6 EMC90460.1 - 0.00023 20.7 13.5 0.00023 20.7 13.5 1.6 1 1 1 2 2 2 1 X-domain of DnaJ-containing UCH PF00443.29 EMC90460.1 - 0.073 12.5 4.4 0.089 12.3 4.4 1.3 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Imm42 PF15593.6 EMC90460.1 - 4 7.9 8.1 24 5.4 8.1 2.0 1 1 0 1 1 1 0 Immunity protein 42 SICA_beta PF12878.7 EMC90460.1 - 4.3 7.5 13.5 12 6.0 13.5 1.8 1 1 0 1 1 1 0 SICA extracellular beta domain Vg_Tdu PF07545.14 EMC90461.1 - 7e-21 73.7 0.4 9.4e-21 73.3 0.4 1.2 1 0 0 1 1 1 1 Vestigial/Tondu family HNOB PF07700.15 EMC90461.1 - 0.017 15.1 0.0 0.02 14.9 0.0 1.1 1 0 0 1 1 1 0 Haem-NO-binding Ig_3 PF13927.6 EMC90462.1 - 4.5e-29 100.9 0.3 3.7e-13 49.9 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 EMC90462.1 - 1.4e-23 82.7 0.0 1.2e-10 41.4 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC90462.1 - 1.6e-21 76.4 0.1 3.9e-09 36.7 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 EMC90462.1 - 4.3e-21 74.9 0.1 9.8e-08 32.1 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.12 EMC90462.1 - 1.5e-16 60.2 3.7 4.6e-15 55.4 0.0 2.7 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 EMC90462.1 - 9.1e-14 51.6 0.3 0.0034 17.5 0.0 4.2 3 1 1 4 4 4 3 Immunoglobulin V-set domain C1-set PF07654.15 EMC90462.1 - 4.1e-10 39.9 0.1 4.3e-09 36.6 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_5 PF16681.5 EMC90462.1 - 5.9e-07 29.8 0.0 0.027 14.8 0.0 3.2 3 0 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 EMC90462.1 - 8.1e-06 26.0 0.0 0.051 13.8 0.0 3.5 3 1 0 3 3 3 2 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 EMC90462.1 - 0.00027 20.9 0.0 1.8 8.7 0.0 3.2 3 0 0 3 3 3 2 Izumo-like Immunoglobulin domain BPD_transp_1 PF00528.22 EMC90462.1 - 0.11 12.2 1.5 0.16 11.7 1.5 1.1 1 0 0 1 1 1 0 Binding-protein-dependent transport system inner membrane component Alpha-amylase_C PF02806.18 EMC90464.1 - 1.5e-17 63.8 0.1 6.4e-17 61.8 0.1 2.1 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 EMC90464.1 - 1e-16 61.0 0.1 2.2e-16 60.0 0.1 1.6 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 EMC90464.1 - 4.3e-15 56.1 0.3 9.6e-12 45.1 0.2 2.4 1 1 1 2 2 2 2 Alpha amylase, catalytic domain hDGE_amylase PF14701.6 EMC90464.1 - 0.031 13.4 0.4 0.065 12.3 0.1 1.6 2 0 0 2 2 2 0 Glycogen debranching enzyme, glucanotransferase domain AMPK1_CBM PF16561.5 EMC90464.1 - 0.12 12.6 0.1 0.32 11.2 0.1 1.7 1 0 0 1 1 1 0 Glycogen recognition site of AMP-activated protein kinase I-set PF07679.16 EMC90466.1 - 8.3e-72 237.3 0.0 9.2e-23 80.1 0.0 4.7 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC90466.1 - 6.2e-63 209.4 0.7 7.4e-17 61.7 0.1 5.8 5 0 0 5 5 5 4 Immunoglobulin domain ig PF00047.25 EMC90466.1 - 1.3e-37 127.9 0.0 2e-09 37.5 0.0 4.7 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 EMC90466.1 - 1.3e-34 118.4 0.0 1.1e-08 35.3 0.0 5.3 5 0 0 5 5 5 4 Immunoglobulin domain fn3 PF00041.21 EMC90466.1 - 1.2e-32 112.1 9.6 2.9e-12 46.8 0.3 4.0 3 0 0 3 3 3 3 Fibronectin type III domain V-set PF07686.17 EMC90466.1 - 3.4e-22 78.7 6.9 4.3e-09 36.5 0.0 7.4 6 2 0 6 6 6 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC90466.1 - 3.6e-09 36.6 4.7 0.18 11.9 0.0 5.8 6 0 0 6 6 6 3 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 EMC90466.1 - 4e-09 35.9 0.0 1.2 8.7 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain Ig_5 PF16681.5 EMC90466.1 - 1e-08 35.5 0.0 0.63 10.5 0.0 4.8 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_C17orf99 PF17736.1 EMC90466.1 - 0.00045 20.2 0.0 6.3 6.9 0.0 4.5 4 1 1 5 5 5 1 C17orf99 Ig domain Pur_ac_phosph_N PF16656.5 EMC90466.1 - 0.002 18.7 3.8 0.45 11.1 0.2 3.6 3 1 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain Big_4 PF07532.11 EMC90466.1 - 0.049 13.4 1.4 0.43 10.3 0.2 2.8 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 4) Izumo-Ig PF16706.5 EMC90466.1 - 0.065 13.3 0.2 44 4.2 0.0 4.0 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain fn3_4 PF16794.5 EMC90466.1 - 0.09 12.7 0.0 10 6.1 0.0 2.8 2 0 0 2 2 2 0 Fibronectin-III type domain Receptor_2B4 PF11465.8 EMC90466.1 - 0.098 12.9 0.1 44 4.3 0.0 4.1 5 0 0 5 5 5 0 Natural killer cell receptor 2B4 I-set PF07679.16 EMC90467.1 - 1.1e-74 246.6 0.0 5.3e-23 80.9 0.0 5.0 5 0 0 5 5 5 4 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC90467.1 - 6.6e-65 215.7 0.9 7.5e-16 58.5 0.1 5.8 5 0 0 5 5 5 4 Immunoglobulin domain Ig_2 PF13895.6 EMC90467.1 - 8.6e-44 147.8 0.1 9.8e-12 45.1 0.0 4.7 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 EMC90467.1 - 7.1e-43 144.7 0.0 2.9e-09 37.0 0.0 4.9 4 0 0 4 4 4 4 Immunoglobulin domain fn3 PF00041.21 EMC90467.1 - 5.9e-37 125.9 11.9 9e-15 54.8 0.9 4.2 3 0 0 3 3 3 3 Fibronectin type III domain V-set PF07686.17 EMC90467.1 - 8.6e-27 93.5 13.6 2.4e-08 34.1 0.0 7.7 7 3 1 8 8 6 4 Immunoglobulin V-set domain Ig_6 PF18452.1 EMC90467.1 - 4.5e-14 51.8 0.0 0.00053 19.5 0.0 4.4 4 0 0 4 4 4 4 Immunoglobulin domain Ig_5 PF16681.5 EMC90467.1 - 1.6e-08 34.9 0.0 0.14 12.6 0.0 4.7 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 EMC90467.1 - 3.3e-07 30.5 0.0 0.64 10.3 0.0 4.6 4 1 0 4 4 4 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 EMC90467.1 - 7.8e-06 25.9 4.2 4.8 7.3 0.0 5.2 5 0 0 5 5 4 2 CD80-like C2-set immunoglobulin domain Ig_C17orf99 PF17736.1 EMC90467.1 - 0.00012 22.0 0.0 6.1 7.0 0.0 4.1 4 0 0 4 4 4 2 C17orf99 Ig domain Receptor_2B4 PF11465.8 EMC90467.1 - 0.0036 17.5 0.3 9.3 6.5 0.0 4.7 3 2 1 4 4 4 1 Natural killer cell receptor 2B4 Izumo-Ig PF16706.5 EMC90467.1 - 0.013 15.5 0.2 70 3.6 0.0 4.5 5 0 0 5 5 4 0 Izumo-like Immunoglobulin domain Adeno_E3_CR1 PF02440.15 EMC90467.1 - 0.044 13.6 0.1 0.55 10.1 0.0 2.9 4 0 0 4 4 3 0 Adenovirus E3 region protein CR1 C2-set PF05790.15 EMC90467.1 - 0.045 13.9 0.3 23 5.2 0.1 3.8 3 0 0 3 3 3 0 Immunoglobulin C2-set domain fn3_4 PF16794.5 EMC90467.1 - 0.078 12.9 0.1 8.1 6.4 0.0 3.2 3 0 0 3 3 3 0 Fibronectin-III type domain Ig_3 PF13927.6 EMC90468.1 - 2.5e-18 66.4 0.0 3.5e-18 66.0 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC90468.1 - 3.9e-16 58.9 0.0 5.6e-16 58.4 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC90468.1 - 1.1e-12 48.1 0.0 1.5e-12 47.7 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC90468.1 - 2.4e-08 34.0 0.0 5.5e-08 32.9 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 EMC90468.1 - 6.6e-05 23.0 0.0 0.0023 18.1 0.0 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 EMC90468.1 - 0.00024 21.1 0.0 0.00027 20.9 0.0 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain BiPBP_C PF06832.12 EMC90468.1 - 0.05 13.7 0.0 0.069 13.2 0.0 1.3 1 0 0 1 1 1 0 Penicillin-Binding Protein C-terminus Family Ig_6 PF18452.1 EMC90468.1 - 0.085 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Lipase PF00151.19 EMC90469.1 - 6.4e-83 278.8 0.0 8.5e-83 278.4 0.0 1.1 1 0 0 1 1 1 1 Lipase Abhydrolase_1 PF00561.20 EMC90469.1 - 0.025 14.2 0.0 0.039 13.6 0.0 1.4 1 1 0 1 1 1 0 alpha/beta hydrolase fold DUF900 PF05990.12 EMC90469.1 - 0.085 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) HSP70 PF00012.20 EMC90470.1 - 1.1e-109 367.4 0.1 1e-77 261.7 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 EMC90470.1 - 1.4e-14 53.7 0.3 6.3e-11 41.7 0.0 2.8 3 0 0 3 3 3 2 MreB/Mbl protein StbA PF06406.11 EMC90470.1 - 0.039 13.2 0.0 0.072 12.3 0.0 1.5 1 0 0 1 1 1 0 StbA protein SLY PF12485.8 EMC90471.1 - 2.8e-54 184.1 9.6 2.8e-54 184.1 9.6 2.0 2 0 0 2 2 2 1 Lymphocyte signaling adaptor protein SAM_2 PF07647.17 EMC90471.1 - 1.3e-08 34.8 0.2 3e-08 33.6 0.2 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EMC90471.1 - 2.7e-08 34.1 0.1 7.1e-08 32.8 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_2 PF07653.17 EMC90471.1 - 7.7e-05 22.3 0.0 0.00015 21.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMC90471.1 - 0.023 14.3 0.0 0.045 13.4 0.0 1.5 1 0 0 1 1 1 0 SH3 domain SAM_KSR1 PF13543.6 EMC90471.1 - 0.15 12.2 2.3 0.24 11.6 0.1 2.2 2 0 0 2 2 2 0 SAM like domain present in kinase suppressor RAS 1 RNA_binding PF01877.17 EMC90471.1 - 0.2 11.9 1.4 20 5.5 0.1 2.8 3 0 0 3 3 3 0 RNA binding V-set PF07686.17 EMC90473.1 - 2.9e-25 88.5 1.2 6.1e-19 68.2 0.0 3.2 2 1 1 3 3 3 2 Immunoglobulin V-set domain I-set PF07679.16 EMC90473.1 - 2.2e-18 66.1 0.1 2.7e-09 36.9 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC90473.1 - 5.4e-17 62.2 0.5 1.2e-09 38.6 0.2 2.8 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 EMC90473.1 - 6.1e-17 61.7 1.4 6.8e-11 42.4 0.2 3.2 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 EMC90473.1 - 1.9e-16 60.0 0.1 2.1e-08 34.2 0.1 2.9 2 1 0 2 2 2 2 Immunoglobulin domain Ig_6 PF18452.1 EMC90473.1 - 1e-05 25.0 0.0 0.053 13.1 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_C17orf99 PF17736.1 EMC90473.1 - 2.5e-05 24.2 0.0 0.016 15.2 0.0 3.0 3 0 0 3 3 3 1 C17orf99 Ig domain Ig_4 PF16680.5 EMC90473.1 - 3.1e-05 24.1 0.3 0.019 15.2 0.2 3.1 2 1 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 EMC90473.1 - 0.00029 21.2 1.7 0.01 16.2 0.0 3.1 4 0 0 4 4 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set_CD47 PF08204.11 EMC90473.1 - 0.00095 19.2 0.0 2.2 8.3 0.0 2.5 2 1 0 2 2 2 2 CD47 immunoglobulin-like domain Izumo-Ig PF16706.5 EMC90473.1 - 0.0012 18.9 0.0 0.28 11.3 0.0 2.5 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain Syndecan PF01034.20 EMC90473.1 - 0.0076 16.1 0.0 0.045 13.7 0.0 2.3 3 0 0 3 3 3 1 Syndecan domain FAM163 PF15069.6 EMC90473.1 - 0.022 15.2 0.0 0.04 14.4 0.0 1.4 1 0 0 1 1 1 0 FAM163 family C2-set PF05790.15 EMC90473.1 - 0.023 14.9 0.6 1.9 8.7 0.0 2.9 3 0 0 3 3 3 0 Immunoglobulin C2-set domain Herpes_gE PF02480.16 EMC90473.1 - 0.025 13.4 0.0 10 4.7 0.0 2.9 1 1 1 3 3 3 0 Alphaherpesvirus glycoprotein E PetG PF02529.15 EMC90473.1 - 0.025 14.4 0.6 0.045 13.6 0.6 1.3 1 0 0 1 1 1 0 Cytochrome B6-F complex subunit 5 Adeno_E3_CR2 PF02439.15 EMC90473.1 - 0.12 12.2 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 EURL PF06937.11 EMC90474.1 - 1.4e-132 441.4 1.9 1.5e-132 441.3 1.9 1.0 1 0 0 1 1 1 1 EURL protein XRCC4 PF06632.12 EMC90474.1 - 0.0046 15.8 0.8 0.0081 15.1 0.8 1.4 1 0 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 Fzo_mitofusin PF04799.13 EMC90474.1 - 0.02 14.5 0.6 0.034 13.7 0.6 1.3 1 0 0 1 1 1 0 fzo-like conserved region Dimerisation2 PF16864.5 EMC90474.1 - 0.052 13.5 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 Dimerisation domain GST_N_4 PF17172.4 EMC90474.1 - 0.37 11.5 3.1 1.3 9.8 0.2 2.4 2 1 0 2 2 2 0 Glutathione S-transferase N-terminal domain Lectin_C PF00059.21 EMC90475.1 - 4.3e-14 53.1 0.2 7.3e-14 52.4 0.2 1.4 1 0 0 1 1 1 1 Lectin C-type domain DUF3377 PF11857.8 EMC90475.1 - 0.079 12.9 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Trypsin PF00089.26 EMC90476.1 - 2e-72 243.6 0.3 2.2e-72 243.5 0.3 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 EMC90476.1 - 7.9e-10 39.1 0.2 1.3e-09 38.5 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 EMC90476.1 - 0.0012 19.8 0.0 0.0019 19.1 0.0 1.3 1 1 0 1 1 1 1 Trypsin-like peptidase domain Lipase PF00151.19 EMC90477.1 - 5.8e-100 334.9 0.0 6.8e-100 334.6 0.0 1.1 1 0 0 1 1 1 1 Lipase Abhydrolase_6 PF12697.7 EMC90477.1 - 0.0011 19.6 2.9 0.0015 19.1 2.9 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ig_3 PF13927.6 EMC90478.1 - 2.7e-09 37.5 0.1 0.0016 19.0 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 EMC90478.1 - 3.3e-06 27.2 1.0 0.11 12.7 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 EMC90478.1 - 5.8e-06 26.3 0.1 0.0023 17.9 0.0 2.4 2 1 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 EMC90478.1 - 1.1e-05 25.6 0.1 0.00021 21.4 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin V-set domain Receptor_2B4 PF11465.8 EMC90478.1 - 0.00057 20.1 0.2 0.068 13.4 0.0 2.2 2 0 0 2 2 2 1 Natural killer cell receptor 2B4 Ig_2 PF13895.6 EMC90478.1 - 0.0019 18.5 1.0 0.3 11.5 0.0 2.4 1 1 1 2 2 2 2 Immunoglobulin domain DUF2139 PF09910.9 EMC90478.1 - 0.0021 17.3 0.0 0.0029 16.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2139) Herpes_gE PF02480.16 EMC90478.1 - 0.095 11.4 0.0 0.098 11.4 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Ig_5 PF16681.5 EMC90478.1 - 0.17 12.3 2.1 1.5 9.3 0.1 2.3 2 1 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Neur PF00064.18 EMC90479.1 - 0.054 12.3 0.0 0.072 11.9 0.0 1.1 1 0 0 1 1 1 0 Neuraminidase Cation_ATPase_C PF00689.21 EMC90480.1 - 9.5e-45 152.5 0.4 9.5e-45 152.5 0.4 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EMC90480.1 - 4.9e-44 150.0 0.6 4.9e-44 150.0 0.6 2.9 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 EMC90480.1 - 2.7e-24 85.0 0.0 6.2e-24 83.9 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EMC90480.1 - 8.9e-19 68.6 0.2 2.8e-15 57.2 0.2 3.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EMC90480.1 - 2.4e-17 62.4 0.0 4.6e-17 61.5 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EMC90480.1 - 6.3e-06 26.1 0.9 0.00081 19.2 0.5 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Mab-21 PF03281.14 EMC90481.1 - 2.8e-81 273.1 5.4 2.8e-81 273.1 5.4 1.4 2 0 0 2 2 2 1 Mab-21 protein SAM_3 PF18016.1 EMC90481.1 - 0.075 12.8 0.3 0.16 11.8 0.3 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) rve PF00665.26 EMC90482.1 - 4.6e-11 43.0 0.0 7.1e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain MFS_1 PF07690.16 EMC90483.1 - 4e-30 104.9 47.3 6.4e-24 84.5 31.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMC90483.1 - 8.5e-29 100.7 15.7 1.2e-28 100.2 15.7 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter RVT_1 PF00078.27 EMC90484.1 - 0.0036 16.9 0.0 0.0067 16.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Calsequestrin PF01216.17 EMC90485.1 - 1.1e-210 699.5 48.3 5.6e-210 697.2 48.3 1.9 1 1 0 1 1 1 1 Calsequestrin Thioredoxin_6 PF13848.6 EMC90485.1 - 1.2e-20 74.2 4.4 4.5e-19 69.1 2.5 2.3 2 1 0 2 2 2 2 Thioredoxin-like domain SDA1 PF05285.12 EMC90485.1 - 0.064 12.7 18.0 0.092 12.2 18.0 1.3 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 EMC90485.1 - 7.1 4.8 21.2 9.8 4.3 21.2 1.2 1 0 0 1 1 1 0 CDC45-like protein Strabismus PF06638.11 EMC90486.1 - 5.9e-249 826.8 0.1 6.8e-249 826.6 0.1 1.0 1 0 0 1 1 1 1 Strabismus protein CDT1_C PF16679.5 EMC90486.1 - 0.026 15.0 2.4 0.038 14.4 1.5 1.6 1 1 0 1 1 1 0 DNA replication factor Cdt1 C-terminal domain DUF3253 PF11625.8 EMC90486.1 - 0.086 13.1 0.7 0.43 10.8 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3253) SNF2_N PF00176.23 EMC90487.1 - 4.8e-57 193.3 0.2 1.2e-56 192.0 0.2 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EMC90487.1 - 1.8e-15 57.3 0.1 1.4e-14 54.4 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMC90487.1 - 6e-11 42.6 0.0 1.6e-10 41.2 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EMC90487.1 - 4.3e-06 26.6 0.0 7.6e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 EMC90487.1 - 0.00094 18.4 0.2 0.0037 16.5 0.0 2.1 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 AAA_22 PF13401.6 EMC90487.1 - 0.016 15.5 0.0 0.069 13.4 0.0 2.1 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EMC90487.1 - 0.043 13.1 0.5 0.14 11.4 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) TT_ORF2 PF02957.15 EMC90487.1 - 0.2 12.6 2.3 0.42 11.5 2.3 1.5 1 0 0 1 1 1 0 TT viral ORF2 Amidase PF01425.21 EMC90488.1 - 5.7e-89 299.1 0.0 3.6e-88 296.5 0.0 1.8 1 1 0 1 1 1 1 Amidase Tmp39 PF10271.9 EMC90489.1 - 5.3e-170 566.1 19.1 1.2e-169 565.0 19.1 1.5 1 1 0 1 1 1 1 Putative transmembrane protein Glyco_transf_7N PF13733.6 EMC90490.1 - 4.7e-58 194.6 0.1 7e-58 194.0 0.1 1.3 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.14 EMC90490.1 - 5.5e-28 96.4 0.4 1.4e-27 95.1 0.4 1.7 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_transf_7N PF13733.6 EMC90491.1 - 1.4e-50 170.4 0.1 2e-50 169.9 0.1 1.2 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.14 EMC90491.1 - 5.7e-19 67.6 0.1 1.1e-18 66.7 0.1 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_transf_43 PF03360.16 EMC90492.1 - 5.3e-72 241.9 0.0 6.4e-72 241.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 43 RhoGAP PF00620.27 EMC90493.1 - 9.1e-44 148.9 0.1 2.1e-43 147.8 0.1 1.6 1 0 0 1 1 1 1 RhoGAP domain Tetraspanin PF00335.20 EMC90494.1 - 1e-25 90.8 5.2 1.4e-25 90.4 5.2 1.1 1 0 0 1 1 1 1 Tetraspanin family RasGEF_N PF00618.20 EMC90494.1 - 0.0074 16.5 0.0 0.012 15.8 0.0 1.3 1 0 0 1 1 1 1 RasGEF N-terminal motif Phage_tail_APC PF16778.5 EMC90494.1 - 0.12 12.3 0.1 0.19 11.6 0.1 1.4 1 0 0 1 1 1 0 Phage tail assembly chaperone protein Tox-ART-HYE1 PF15634.6 EMC90494.1 - 0.17 11.2 0.0 0.22 10.8 0.0 1.1 1 0 0 1 1 1 0 HYE1 signature containing ADP-ribosyltransferase PepSY_TM PF03929.16 EMC90494.1 - 4.8 6.8 6.2 1.6 8.3 0.0 2.3 3 0 0 3 3 3 0 PepSY-associated TM region I-set PF07679.16 EMC90495.1 - 9.4e-40 134.6 2.0 7.8e-16 57.9 0.0 3.6 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 EMC90495.1 - 1.7e-39 134.2 4.0 6.3e-17 61.9 0.1 3.2 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 EMC90495.1 - 1.1e-29 102.6 1.3 6.5e-13 48.8 0.1 3.2 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 EMC90495.1 - 6.4e-26 90.4 0.7 2.6e-11 43.5 0.0 3.9 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 EMC90495.1 - 3.4e-17 62.6 1.4 2.5e-05 24.4 0.0 5.1 3 2 1 4 4 4 4 Immunoglobulin V-set domain Ig_5 PF16681.5 EMC90495.1 - 5.5e-11 42.7 0.2 0.034 14.6 0.0 3.6 3 1 0 3 3 3 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 EMC90495.1 - 3.9e-08 33.2 0.6 0.0076 16.3 0.1 3.5 3 0 0 3 3 3 2 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 EMC90495.1 - 2.1e-07 31.1 2.6 0.11 12.7 0.0 4.2 3 2 1 4 4 4 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 EMC90495.1 - 3e-06 27.2 1.1 0.11 12.6 0.0 2.7 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 EMC90495.1 - 7.7e-06 25.4 0.0 0.072 12.7 0.0 3.3 3 0 0 3 3 3 1 Immunoglobulin domain V-set_CD47 PF08204.11 EMC90495.1 - 0.00021 21.3 1.2 0.29 11.1 0.2 3.2 2 1 1 3 3 3 2 CD47 immunoglobulin-like domain Adeno_E3_CR1 PF02440.15 EMC90495.1 - 0.0015 18.3 3.2 4.5 7.1 0.2 4.0 3 1 0 3 3 3 2 Adenovirus E3 region protein CR1 Ig_C17orf99 PF17736.1 EMC90495.1 - 0.0018 18.2 1.1 1.1 9.4 0.1 4.0 3 2 0 3 3 3 1 C17orf99 Ig domain C2-set PF05790.15 EMC90495.1 - 0.016 15.4 0.1 4.9 7.4 0.0 3.7 4 0 0 4 4 4 0 Immunoglobulin C2-set domain BTB PF00651.31 EMC90496.1 - 6.3e-24 84.3 0.1 1.9e-23 82.8 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain zf-C2H2 PF00096.26 EMC90496.1 - 3.2e-22 77.7 42.1 1e-06 28.8 1.9 6.2 6 0 0 6 6 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC90496.1 - 3.4e-20 71.5 42.7 1.9e-06 28.0 2.7 7.2 7 1 0 7 7 6 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC90496.1 - 1e-15 57.0 35.3 0.00021 21.9 1.5 6.1 5 0 0 5 5 5 5 C2H2-type zinc finger zf-met PF12874.7 EMC90496.1 - 1.4e-06 28.5 34.2 0.0035 17.7 1.1 5.9 6 0 0 6 6 6 3 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 EMC90496.1 - 1.1e-05 25.2 6.4 0.43 10.5 0.0 4.4 4 0 0 4 4 4 3 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.6 EMC90496.1 - 4.5e-05 23.3 29.2 0.0024 17.8 0.6 5.6 5 0 0 5 5 5 3 C2H2-type zinc finger BolA PF01722.18 EMC90496.1 - 0.0012 19.1 1.3 0.66 10.3 0.2 3.8 2 1 1 3 3 3 1 BolA-like protein zf-C2H2_2 PF12756.7 EMC90496.1 - 0.0021 18.4 23.8 0.022 15.1 9.3 4.2 2 1 1 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 EMC90496.1 - 0.0046 16.7 18.3 0.78 9.5 2.0 4.9 5 0 0 5 5 5 2 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 EMC90496.1 - 0.0069 16.6 21.4 0.1 12.9 0.7 4.7 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 EMC90496.1 - 0.016 15.5 22.2 1.4 9.3 3.4 4.2 2 1 3 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding zf-RING_11 PF17123.5 EMC90496.1 - 0.22 11.3 8.5 18 5.2 0.0 4.8 5 0 0 5 5 5 0 RING-like zinc finger DUF2225 PF09986.9 EMC90496.1 - 2.2 7.9 13.0 1.4 8.6 0.2 3.9 3 1 1 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2225) Endonuclease_7 PF02945.15 EMC90496.1 - 4.4 7.3 13.0 1.6 8.7 4.4 3.6 1 1 1 2 2 2 0 Recombination endonuclease VII HNH_5 PF14279.6 EMC90496.1 - 7.1 6.6 13.5 2.3 8.1 0.2 4.0 4 1 0 4 4 4 0 HNH endonuclease 7tm_1 PF00001.21 EMC90497.1 - 3e-77 259.5 13.5 4.3e-77 259.0 13.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC90497.1 - 2.5e-10 40.2 19.2 8.7e-08 31.9 15.4 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 EMC90497.1 - 2.7e-05 23.9 15.2 2.7e-05 23.9 15.2 2.2 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx TGT PF01702.18 EMC90498.1 - 4.6e-79 266.1 0.0 5.1e-79 266.0 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase ANAPC5 PF12862.7 EMC90499.1 - 0.13 12.4 1.5 23 5.1 0.1 3.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 5 Hydrolase PF00702.26 EMC90499.1 - 7.2 6.8 6.5 1.4 9.2 1.5 2.2 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase DHHC PF01529.20 EMC90500.1 - 2.8e-31 108.4 8.5 2.8e-31 108.4 8.5 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF1700 PF08006.11 EMC90500.1 - 9.5 5.7 10.5 2.2 7.8 3.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) VASt PF16016.5 EMC90501.1 - 1.4e-35 123.0 2.9 2.6e-35 122.1 2.9 1.5 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EMC90501.1 - 3.8e-27 94.4 0.6 8e-27 93.4 0.2 1.8 2 0 0 2 2 2 1 GRAM domain TarH PF02203.15 EMC90501.1 - 0.027 14.4 0.4 0.027 14.4 0.4 1.7 2 0 0 2 2 2 0 Tar ligand binding domain homologue DUF4446 PF14584.6 EMC90501.1 - 0.18 11.8 1.5 0.4 10.7 1.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) V-set PF07686.17 EMC90502.1 - 9.7e-17 61.1 0.0 1.4e-16 60.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 EMC90502.1 - 2.9e-09 37.0 0.0 4.7e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 EMC90502.1 - 1.4e-08 35.2 0.0 2.6e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 EMC90502.1 - 3.5e-08 33.7 0.0 8e-08 32.5 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC90502.1 - 4.5e-08 33.1 0.0 9.5e-08 32.0 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set_CD47 PF08204.11 EMC90502.1 - 0.00014 21.9 0.0 0.00019 21.4 0.0 1.2 1 0 0 1 1 1 1 CD47 immunoglobulin-like domain DUF3872 PF12988.7 EMC90502.1 - 0.038 13.8 0.0 0.058 13.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3872) Adeno_E3_CR1 PF02440.15 EMC90502.1 - 0.055 13.3 0.0 0.097 12.5 0.0 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR1 Receptor_2B4 PF11465.8 EMC90502.1 - 0.12 12.6 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 Natural killer cell receptor 2B4 Phospholip_A2_1 PF00068.19 EMC90503.1 - 2.3e-33 115.0 13.7 3.1e-33 114.6 13.7 1.2 1 0 0 1 1 1 1 Phospholipase A2 Parvo_coat_N PF08398.10 EMC90503.1 - 0.0021 18.2 0.0 0.0033 17.5 0.0 1.3 1 0 0 1 1 1 1 Parvovirus coat protein VP1 7tm_1 PF00001.21 EMC90504.1 - 1.9e-51 175.0 14.5 2.6e-51 174.5 14.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC90504.1 - 5.5e-09 35.8 17.4 7.7e-09 35.3 17.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 EMC90504.1 - 0.00042 19.8 12.2 0.00042 19.8 12.2 1.8 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv TctB PF07331.11 EMC90504.1 - 0.0063 16.8 1.7 0.0063 16.8 1.7 2.5 2 1 0 2 2 2 1 Tripartite tricarboxylate transporter TctB family Abhydrolase_9_N PF15420.6 EMC90504.1 - 0.35 10.9 1.5 1 9.3 0.4 1.9 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus UPF0182 PF03699.13 EMC90504.1 - 1.3 7.0 9.1 2.7 6.0 9.1 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0182) DUF1422 PF07226.11 EMC90504.1 - 5.1 7.1 8.6 0.87 9.6 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1422) Apo-VLDL-II PF05418.11 EMC90505.1 - 2.5e-41 140.1 1.3 3e-41 139.8 1.3 1.1 1 0 0 1 1 1 1 Apovitellenin I (Apo-VLDL-II) Tmpp129 PF10272.9 EMC90505.1 - 0.083 12.2 0.1 0.097 12.0 0.1 1.2 1 0 0 1 1 1 0 Putative transmembrane protein precursor LSR PF05624.14 EMC90506.1 - 5.1e-22 77.6 36.6 7.7e-22 77.0 36.6 1.3 1 0 0 1 1 1 1 Lipolysis stimulated receptor (LSR) V-set PF07686.17 EMC90506.1 - 3.1e-06 27.3 2.9 0.00055 20.1 0.0 2.9 2 1 1 3 3 3 2 Immunoglobulin V-set domain ig PF00047.25 EMC90506.1 - 0.021 15.0 0.1 1.7 8.9 0.0 2.7 2 0 0 2 2 2 0 Immunoglobulin domain I-set PF07679.16 EMC90506.1 - 0.13 12.3 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin I-set domain WD40 PF00400.32 EMC90507.1 - 6e-18 64.9 1.5 0.0086 16.9 0.0 8.6 10 0 0 10 10 10 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMC90507.1 - 4.6e-09 36.5 0.0 0.091 13.1 0.0 4.8 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Plk4_PB1 PF18190.1 EMC90507.1 - 0.054 13.7 0.0 0.18 12.0 0.0 1.9 1 0 0 1 1 1 0 Polo-like Kinase 4 Polo Box 1 Cytochrom_D1 PF02239.16 EMC90507.1 - 0.075 11.5 0.0 6.9 5.1 0.0 2.3 2 0 0 2 2 2 0 Cytochrome D1 heme domain HELP PF03451.14 EMC90507.1 - 0.1 12.5 0.0 0.41 10.5 0.0 2.1 2 0 0 2 2 2 0 HELP motif Ge1_WD40 PF16529.5 EMC90507.1 - 0.13 11.2 0.0 25 3.7 0.0 3.2 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 EMC90507.1 - 0.17 12.4 0.0 2.9 8.5 0.0 3.1 4 0 0 4 4 4 0 PQQ-like domain TORC_N PF12884.7 EMC90507.1 - 7.8 7.4 8.4 6.3 7.7 2.1 2.5 2 0 0 2 2 2 0 Transducer of regulated CREB activity, N terminus DUF1043 PF06295.12 EMC90508.1 - 0.02 14.9 1.1 0.02 14.9 1.1 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1043) DWNN PF08783.11 EMC90508.1 - 0.063 13.6 0.1 0.063 13.6 0.1 2.6 2 0 0 2 2 2 0 DWNN domain CENP-B_dimeris PF09026.10 EMC90508.1 - 0.54 10.7 7.3 38 4.8 5.7 2.7 2 1 0 2 2 2 0 Centromere protein B dimerisation domain DUF4407 PF14362.6 EMC90508.1 - 4.8 6.4 17.0 0.62 9.4 7.6 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) KIND PF16474.5 EMC90509.1 - 1.4e-43 149.1 1.6 1.3e-33 116.5 0.0 2.2 1 1 1 2 2 2 2 Kinase non-catalytic C-lobe domain DUF4477 PF14780.6 EMC90510.1 - 1.8e-50 171.3 3.4 2.4e-50 170.8 3.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4477) TFIID-18kDa PF02269.16 EMC90511.1 - 6.1e-35 119.1 0.1 8e-35 118.7 0.1 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit GTP_EFTU PF00009.27 EMC90512.1 - 0.0022 17.5 0.0 0.0026 17.4 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EMC90512.1 - 0.0045 17.1 0.0 0.0058 16.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase V-set PF07686.17 EMC90513.1 - 3.5e-08 33.6 0.4 7e-08 32.6 0.4 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC90513.1 - 1.3e-05 25.7 2.8 0.11 13.1 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 EMC90513.1 - 2.4e-05 24.3 0.2 5.3e-05 23.2 0.2 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain I-set PF07679.16 EMC90513.1 - 0.00021 21.3 0.1 0.0072 16.4 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.25 EMC90513.1 - 0.0032 17.6 6.9 0.25 11.6 0.4 2.8 2 2 0 2 2 2 2 Immunoglobulin domain Izumo-Ig PF16706.5 EMC90513.1 - 0.034 14.2 0.1 0.78 9.8 0.0 2.3 1 1 1 2 2 2 0 Izumo-like Immunoglobulin domain V-set_CD47 PF08204.11 EMC90513.1 - 0.076 13.0 1.1 0.23 11.4 1.1 1.9 1 1 0 1 1 1 0 CD47 immunoglobulin-like domain V-set PF07686.17 EMC90514.1 - 2.1e-09 37.5 0.7 4.9e-09 36.3 0.7 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC90514.1 - 3.9e-06 27.4 5.4 0.0069 17.0 1.3 2.6 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 EMC90514.1 - 4.8e-05 23.3 0.2 0.00016 21.6 0.2 1.9 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain I-set PF07679.16 EMC90514.1 - 0.00024 21.1 0.9 0.0044 17.1 0.2 2.6 2 1 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.25 EMC90514.1 - 0.0013 18.9 8.0 0.4 10.9 0.5 2.8 2 1 0 2 2 2 2 Immunoglobulin domain V-set_CD47 PF08204.11 EMC90514.1 - 0.067 13.2 3.4 0.24 11.4 3.4 2.0 1 1 0 1 1 1 0 CD47 immunoglobulin-like domain DUF4174 PF13778.6 EMC90515.1 - 7.2e-106 349.2 0.0 1e-37 129.3 1.4 3.5 3 0 0 3 3 3 3 Domain of unknown function (DUF4174) Nuc_sug_transp PF04142.15 EMC90516.1 - 7.7e-50 169.8 10.1 1.1e-49 169.3 10.1 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 EMC90516.1 - 1.7e-06 28.3 5.4 1.7e-06 28.3 5.4 3.2 3 1 0 3 3 3 1 EamA-like transporter family Autophagy_N PF03986.13 EMC90517.1 - 2.5e-36 124.6 1.8 2.6e-36 124.6 0.6 1.6 1 1 1 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 EMC90517.1 - 1.4e-20 73.6 4.1 2.9e-20 72.6 4.1 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 EMC90517.1 - 5e-16 57.9 0.7 9.3e-16 57.0 0.7 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal SDA1 PF05285.12 EMC90517.1 - 0.2 11.0 4.2 0.24 10.8 4.2 1.1 1 0 0 1 1 1 0 SDA1 F5_F8_type_C PF00754.25 EMC90518.1 - 5.4e-55 184.9 5.4 2.9e-28 98.5 1.8 3.0 2 0 0 2 2 2 2 F5/8 type C domain Cu-oxidase_3 PF07732.15 EMC90518.1 - 6.8e-31 106.8 0.3 6.6e-09 35.8 0.0 5.4 5 1 0 5 5 5 4 Multicopper oxidase Cu-oxidase_2 PF07731.14 EMC90518.1 - 2.8e-13 49.8 9.7 0.00082 19.1 0.2 6.1 6 0 0 6 6 6 4 Multicopper oxidase Cu-oxidase PF00394.22 EMC90518.1 - 1.5e-06 28.4 3.2 0.11 12.6 0.0 4.4 5 0 0 5 5 5 3 Multicopper oxidase Folate_carrier PF01770.18 EMC90519.1 - 6e-156 519.3 25.0 7.1e-156 519.1 25.0 1.0 1 0 0 1 1 1 1 Reduced folate carrier MFS_1 PF07690.16 EMC90519.1 - 4.1e-10 39.1 18.6 4.1e-10 39.1 18.6 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4207 PF13904.6 EMC90520.1 - 0.0012 18.6 18.9 0.0012 18.6 18.9 3.6 2 2 1 3 3 3 2 Domain of unknown function (DUF4207) MMPL PF03176.15 EMC90520.1 - 0.42 9.5 0.7 0.7 8.8 0.7 1.3 1 0 0 1 1 1 0 MMPL family DASH_Hsk3 PF08227.11 EMC90521.1 - 1e-09 38.6 0.2 1e-09 38.6 0.2 2.7 3 0 0 3 3 3 1 DASH complex subunit Hsk3 like CC2-LZ PF16516.5 EMC90521.1 - 0.1 13.0 0.5 0.1 13.0 0.5 3.3 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator KASH_CCD PF14662.6 EMC90521.1 - 0.31 10.8 17.9 0.66 9.8 17.9 1.5 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH MbeD_MobD PF04899.12 EMC90521.1 - 1 9.5 10.3 0.3 11.2 0.7 3.2 1 1 2 3 3 3 0 MbeD/MobD like PI3K_P85_iSH2 PF16454.5 EMC90521.1 - 1.8 8.1 15.5 0.083 12.5 3.3 2.6 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain NDK PF00334.19 EMC90522.1 - 8e-72 239.6 0.0 3.7e-41 140.3 0.0 2.1 2 0 0 2 2 2 2 Nucleoside diphosphate kinase DUF1126 PF06565.12 EMC90522.1 - 1.7e-05 24.6 0.8 5e-05 23.1 0.3 2.0 2 0 0 2 2 2 1 DUF1126 PH-like domain DERM PF14704.6 EMC90523.1 - 1.5e-37 129.4 8.8 1.8e-37 129.2 8.8 1.1 1 0 0 1 1 1 1 Dermatopontin IL8 PF00048.20 EMC90524.1 - 1.6e-09 37.8 0.4 2.8e-09 37.0 0.4 1.4 1 1 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like T-box PF00907.22 EMC90525.1 - 1.6e-69 233.8 0.0 2.1e-69 233.5 0.0 1.1 1 0 0 1 1 1 1 T-box Got1 PF04178.12 EMC90526.1 - 4.6e-29 101.1 16.2 1.2e-28 99.8 16.3 1.5 1 1 1 2 2 2 1 Got1/Sft2-like family DUF4064 PF13273.6 EMC90526.1 - 0.038 14.3 1.8 0.077 13.3 1.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4064) Bac_export_2 PF01312.19 EMC90526.1 - 0.2 10.8 1.2 0.22 10.7 1.2 1.2 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family DUF2244 PF10003.9 EMC90526.1 - 0.79 9.4 10.4 0.16 11.7 3.6 2.0 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) TraL PF07178.11 EMC90526.1 - 3.5 8.2 7.6 0.61 10.6 0.7 2.5 1 1 0 2 2 2 0 TraL protein TIP41 PF04176.13 EMC90527.1 - 3.9e-67 225.0 0.6 4.8e-67 224.8 0.6 1.1 1 0 0 1 1 1 1 TIP41-like family DGF-1_4 PF11024.8 EMC90527.1 - 0.38 11.6 2.5 0.52 11.2 0.5 2.0 2 0 0 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 7tm_1 PF00001.21 EMC90528.1 - 6.1e-48 163.4 19.1 6.1e-48 163.4 19.1 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 EMC90528.1 - 0.00091 18.9 19.5 0.00091 18.9 19.5 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Serpentine_r_xa PF03383.15 EMC90528.1 - 3.1 7.8 11.5 0.27 11.2 2.3 2.3 2 0 0 2 2 2 0 Caenorhabditis serpentine receptor-like protein, class xa SNF2_N PF00176.23 EMC90529.1 - 2.2e-72 243.7 3.8 9.4e-72 241.6 0.3 2.2 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EMC90529.1 - 3.9e-14 52.9 0.0 1.3e-13 51.3 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-GRF PF06839.12 EMC90529.1 - 1.2e-07 31.6 6.1 1.7e-07 31.2 1.1 2.8 2 0 0 2 2 2 1 GRF zinc finger ResIII PF04851.15 EMC90529.1 - 9.3e-07 29.0 0.0 2.7e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Coprogen_oxidas PF01218.18 EMC90530.1 - 1.7e-126 420.9 0.1 1.9e-126 420.8 0.1 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase Glyco_transf_29 PF00777.18 EMC90531.1 - 4.1e-66 223.1 0.0 5.1e-66 222.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) TLV_coat PF00429.19 EMC90532.1 - 1.9e-13 50.0 3.9 2.2e-13 49.8 3.9 1.0 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) Aminoglyc_resit PF10706.9 EMC90532.1 - 0.087 12.5 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Aminoglycoside-2''-adenylyltransferase Caldesmon PF02029.15 EMC90534.1 - 1.1e-08 34.3 55.0 1.7e-08 33.7 55.0 1.3 1 0 0 1 1 1 1 Caldesmon Mitofilin PF09731.9 EMC90534.1 - 0.0071 15.3 51.1 0.0082 15.0 51.1 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein AF-4 PF05110.13 EMC90534.1 - 0.24 9.5 53.6 0.4 8.7 53.6 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Dapper PF15268.6 EMC90534.1 - 0.4 9.5 37.3 0.48 9.2 37.3 1.1 1 0 0 1 1 1 0 Dapper GREB1 PF15782.5 EMC90534.1 - 0.54 7.3 23.4 0.61 7.1 23.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Glypican PF01153.19 EMC90536.1 - 2.6e-219 729.7 2.2 3.2e-219 729.4 2.2 1.0 1 0 0 1 1 1 1 Glypican Fz PF01392.22 EMC90536.1 - 0.0043 17.7 0.4 0.014 16.0 0.4 1.9 1 0 0 1 1 1 1 Fz domain DSPc PF00782.20 EMC90537.1 - 5.5e-31 107.1 0.0 6.1e-31 107.0 0.0 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 EMC90537.1 - 0.0088 16.3 0.0 0.012 15.9 0.0 1.2 1 0 0 1 1 1 1 Rit1 DUSP-like domain Toxin_17 PF08086.11 EMC90537.1 - 0.021 15.1 0.3 0.042 14.1 0.3 1.4 1 0 0 1 1 1 0 Ergtoxin family DSPn PF14671.6 EMC90537.1 - 0.039 14.4 0.0 0.059 13.8 0.0 1.2 1 0 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half LPD5 PF18799.1 EMC90537.1 - 0.048 14.1 0.0 0.064 13.7 0.0 1.1 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 5 Y_phosphatase PF00102.27 EMC90537.1 - 0.12 11.9 0.0 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Transglut_C PF00927.22 EMC90538.1 - 6.9e-38 129.0 0.2 6.3e-19 68.1 0.0 2.4 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_core PF01841.19 EMC90538.1 - 6.2e-16 58.9 0.2 1.4e-15 57.7 0.2 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF2393 PF09624.10 EMC90538.1 - 0.023 14.7 0.9 0.15 12.0 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2393) Poxvirus_B22R PF04395.12 EMC90538.1 - 0.089 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Poxvirus B22R protein SoxY PF13501.6 EMC90538.1 - 0.14 12.4 0.1 0.3 11.3 0.1 1.5 1 0 0 1 1 1 0 Sulfur oxidation protein SoxY Na_sulph_symp PF00939.19 EMC90539.1 - 1.5e-100 337.5 11.6 2.6e-100 336.7 11.6 1.3 1 1 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 EMC90539.1 - 1.1e-32 113.4 28.5 3.6e-19 69.1 4.3 3.1 2 1 1 3 3 3 3 Citrate transporter DUF2207 PF09972.9 EMC90539.1 - 0.046 12.5 0.2 0.046 12.5 0.2 2.4 2 1 1 3 3 3 0 Predicted membrane protein (DUF2207) DNA_III_psi PF03603.13 EMC90539.1 - 0.12 12.6 0.2 0.25 11.6 0.2 1.6 1 0 0 1 1 1 0 DNA polymerase III psi subunit Kdo PF06293.14 EMC90540.1 - 1.1e-09 37.9 0.0 1.3e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EMC90540.1 - 7e-05 22.3 0.0 7.7e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EMC90540.1 - 0.0035 17.3 0.1 0.015 15.2 0.1 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 EMC90540.1 - 0.0085 15.4 0.0 0.0093 15.3 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase RIO1 PF01163.22 EMC90540.1 - 0.0098 15.5 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Pkinase_Tyr PF07714.17 EMC90540.1 - 0.012 14.9 0.0 0.015 14.6 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase TERF2_RBM PF16772.5 EMC90540.1 - 0.05 13.0 0.1 0.1 12.1 0.1 1.5 1 0 0 1 1 1 0 Telomeric repeat-binding factor 2 Rap1-binding motif YrbL-PhoP_reg PF10707.9 EMC90540.1 - 0.14 11.7 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Sugar_tr PF00083.24 EMC90541.1 - 2.9e-90 303.3 25.8 1.1e-65 222.4 11.9 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EMC90541.1 - 4.6e-31 108.0 45.7 1.1e-22 80.5 16.6 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily Hydrolase PF00702.26 EMC90542.1 - 0.00011 22.5 0.0 0.00016 22.1 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase NCOA_u2 PF16665.5 EMC90543.1 - 9.7e-43 145.3 23.5 9.7e-43 145.3 23.5 4.9 4 0 0 4 4 4 1 Unstructured region on nuclear receptor coactivator protein DUF4927 PF16279.5 EMC90543.1 - 7.9e-36 123.0 7.8 7.9e-36 123.0 7.8 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4927) PAS_11 PF14598.6 EMC90543.1 - 2.1e-35 121.3 0.1 2.7e-31 108.0 0.1 2.6 2 0 0 2 2 2 2 PAS domain SRC-1 PF08832.10 EMC90543.1 - 3e-29 101.9 7.2 3e-29 101.9 7.2 5.0 4 0 0 4 4 4 1 Steroid receptor coactivator Nuc_rec_co-act PF08815.10 EMC90543.1 - 4e-25 87.4 2.3 8.3e-25 86.4 2.3 1.6 1 0 0 1 1 1 1 Nuclear receptor coactivator DUF1518 PF07469.12 EMC90543.1 - 3.2e-21 75.5 20.9 3.2e-21 75.5 20.9 7.5 8 1 0 8 8 8 1 Domain of unknown function (DUF1518) PAS PF00989.25 EMC90543.1 - 4.5e-08 33.1 0.0 2.1e-07 30.9 0.0 2.2 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.12 EMC90543.1 - 3.9e-06 27.1 0.1 0.00071 19.8 0.0 2.6 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 EMC90543.1 - 6.3e-05 23.2 0.0 0.00018 21.7 0.0 1.9 1 0 0 1 1 1 1 PAS domain HLH PF00010.26 EMC90543.1 - 0.0018 18.2 0.8 0.0037 17.2 0.8 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF3740 PF12548.8 EMC90544.1 - 3.7e-53 179.9 1.2 3.7e-53 179.9 1.2 2.7 3 0 0 3 3 3 1 Sulfatase protein Sulfatase PF00884.23 EMC90544.1 - 9.5e-49 166.4 1.5 1.4e-48 165.8 1.5 1.3 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EMC90544.1 - 0.0073 15.9 0.2 3.4 7.2 0.0 2.5 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.5 EMC90544.1 - 0.038 14.2 0.0 6.6 7.0 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4976) TPR_MLP1_2 PF07926.12 EMC90544.1 - 0.36 10.9 3.7 2.6 8.1 0.1 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF5082 PF16888.5 EMC90544.1 - 0.41 10.9 3.7 2 8.7 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) Periviscerokin PF08259.11 EMC90545.1 - 3.7e-08 32.6 0.2 9e+02 0.8 0.0 11.1 13 0 0 13 13 13 0 Periviscerokinin family LRR_adjacent PF08191.11 EMC90545.1 - 2.3e-05 24.5 22.8 1.6e+02 2.6 0.0 11.8 2 2 11 13 13 13 0 LRR adjacent Mucin-like PF16058.5 EMC90545.1 - 0.00047 20.2 20.7 0.078 13.1 11.6 2.7 1 1 2 3 3 3 3 Mucin-like FAM47 PF14642.6 EMC90545.1 - 1.7 8.1 22.2 1.1 8.8 5.8 2.1 1 1 1 2 2 2 0 FAM47 family DEP PF00610.21 EMC90546.1 - 3.6e-42 142.3 0.2 3e-21 75.2 0.0 3.4 3 0 0 3 3 3 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RhoGEF PF00621.20 EMC90546.1 - 1.1e-37 130.0 3.4 1.8e-37 129.3 0.4 3.0 3 0 0 3 3 3 1 RhoGEF domain PDZ PF00595.24 EMC90546.1 - 4e-09 36.7 0.0 0.0028 18.0 0.0 2.7 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 EMC90546.1 - 5.9e-08 32.4 0.0 0.0021 17.8 0.0 3.1 3 0 0 3 3 3 2 PDZ domain PH PF00169.29 EMC90546.1 - 3.2e-05 24.4 0.2 0.00023 21.6 0.2 2.5 2 0 0 2 2 2 1 PH domain PDZ_2 PF13180.6 EMC90546.1 - 0.00055 20.2 0.0 0.64 10.4 0.0 2.6 2 0 0 2 2 2 2 PDZ domain PH_10 PF15411.6 EMC90546.1 - 0.0023 18.2 2.3 0.0029 17.8 0.4 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain UPF1_Zn_bind PF09416.10 EMC90546.1 - 0.011 15.7 0.0 0.04 13.9 0.0 1.9 1 0 0 1 1 1 0 RNA helicase (UPF2 interacting domain) IQ_SEC7_PH PF16453.5 EMC90546.1 - 0.026 14.5 0.1 0.076 13.0 0.1 1.7 1 0 0 1 1 1 0 PH domain Cornifin PF02389.15 EMC90547.1 - 1.7 8.8 6.4 2.1 8.5 6.4 1.2 1 0 0 1 1 1 0 Cornifin (SPRR) family DUF3017 PF11222.8 EMC90547.1 - 2.4 8.5 23.8 54 4.1 0.5 5.9 1 1 5 6 6 6 0 Protein of unknown function (DUF3017) Toxin_26 PF08097.11 EMC90547.1 - 8.2 7.3 35.9 7.8 7.4 3.0 6.6 6 0 0 6 6 6 0 Conotoxin T-superfamily CAS_CSE1 PF03378.15 EMC90548.1 - 3.1e-176 586.2 6.1 3.6e-176 586.0 3.7 2.1 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus Cse1 PF08506.10 EMC90548.1 - 7e-169 561.5 5.6 1.5e-168 560.4 5.6 1.6 1 0 0 1 1 1 1 Cse1 IBN_N PF03810.19 EMC90548.1 - 2.3e-11 43.4 0.2 1.6e-10 40.7 0.1 2.6 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EMC90548.1 - 0.012 15.7 7.6 0.012 15.6 0.0 4.2 3 2 1 4 4 4 0 Exportin 1-like protein PUF PF00806.19 EMC90548.1 - 0.05 13.3 0.0 1.2 8.9 0.0 3.1 2 0 0 2 2 2 0 Pumilio-family RNA binding repeat DUF3385 PF11865.8 EMC90548.1 - 0.25 11.2 3.0 0.41 10.5 0.6 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) TSP_1 PF00090.19 EMC90549.1 - 0.00069 19.8 2.7 0.00069 19.8 2.7 2.4 2 0 0 2 2 2 1 Thrombospondin type 1 domain Ion_trans PF00520.31 EMC90550.1 - 1.7e-49 168.3 7.5 2.1e-49 168.0 7.5 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 EMC90550.1 - 1.1e-15 57.8 0.3 3.7e-15 56.0 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain Ion_trans_2 PF07885.16 EMC90550.1 - 9.6e-13 47.9 2.8 9.6e-13 47.9 2.8 2.6 3 0 0 3 3 3 1 Ion channel DUF4790 PF16037.5 EMC90550.1 - 0.29 11.6 4.8 0.1 13.0 1.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4790) ABC2_membrane_4 PF12730.7 EMC90550.1 - 0.57 10.1 0.1 0.57 10.1 0.1 3.1 2 2 1 3 3 3 0 ABC-2 family transporter protein Glyco_transf_7N PF13733.6 EMC90551.1 - 1e-55 187.0 0.0 1.6e-55 186.4 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.14 EMC90551.1 - 4.3e-29 100.0 0.4 7.4e-29 99.2 0.4 1.3 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Na_H_Exchanger PF00999.21 EMC90552.1 - 6.6e-42 143.7 21.9 7.6e-42 143.4 21.9 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family 7tm_1 PF00001.21 EMC90554.1 - 0.00043 19.7 10.8 0.004 16.5 0.4 2.1 2 0 0 2 2 2 2 7 transmembrane receptor (rhodopsin family) TM231 PF10149.9 EMC90554.1 - 6.1 6.1 7.3 0.44 9.8 1.4 1.8 2 0 0 2 2 2 0 Transmembrane protein 231 zf-B_box PF00643.24 EMC90555.1 - 0.17 12.1 16.2 0.83 9.9 3.6 3.1 2 1 0 2 2 2 0 B-box zinc finger HypA PF01155.19 EMC90555.1 - 2.3 8.3 8.7 1.4 9.0 0.4 2.6 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-Di19 PF05605.12 EMC90556.1 - 2.3e-18 66.2 2.4 2.3e-18 66.2 2.4 3.0 2 1 1 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding zf_C2HC_14 PF18574.1 EMC90556.1 - 1.3e-15 56.9 6.7 1.3e-15 56.9 6.7 2.2 2 0 0 2 2 2 1 C2HC Zing finger domain zf-C2H2_4 PF13894.6 EMC90556.1 - 0.025 15.4 1.1 0.025 15.4 1.1 4.5 4 1 0 4 4 4 0 C2H2-type zinc finger DND1_DSRM PF14709.7 EMC90556.1 - 0.026 14.8 0.0 0.074 13.3 0.0 1.8 2 0 0 2 2 2 0 double strand RNA binding domain from DEAD END PROTEIN 1 zf-RRN7 PF11781.8 EMC90556.1 - 0.026 14.2 7.2 0.77 9.5 0.2 3.5 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DZR PF12773.7 EMC90556.1 - 0.29 11.2 17.5 2.7 8.1 1.4 2.6 2 1 0 2 2 2 0 Double zinc ribbon tRNA-synt_1g PF09334.11 EMC90556.1 - 1.3 7.7 6.0 0.39 9.4 1.1 2.0 1 1 1 2 2 2 0 tRNA synthetases class I (M) YdjO PF14169.6 EMC90556.1 - 1.7 8.4 10.1 1.8 8.4 0.0 3.8 4 0 0 4 4 4 0 Cold-inducible protein YdjO zf_UBZ PF18439.1 EMC90556.1 - 6.5 6.5 9.1 2.8 7.6 0.0 3.8 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf-C2H2 PF00096.26 EMC90557.1 - 2.4e-24 84.4 32.5 7.8e-06 26.1 0.7 5.2 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC90557.1 - 4.5e-18 64.4 32.5 0.00016 22.2 1.4 5.2 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC90557.1 - 2.6e-13 49.9 19.1 0.00059 20.0 0.2 5.4 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 EMC90557.1 - 3.9e-13 49.2 38.0 4.1e-07 30.1 0.5 5.9 5 2 0 5 5 5 3 Zinc-finger double domain zf-C2H2_6 PF13912.6 EMC90557.1 - 7.8e-09 35.3 29.3 0.0021 18.0 1.2 5.5 5 0 0 5 5 5 4 C2H2-type zinc finger zf-met PF12874.7 EMC90557.1 - 2e-08 34.3 18.2 0.0042 17.4 0.8 4.4 4 0 0 4 4 4 4 Zinc-finger of C2H2 type zf-C2HE PF16278.5 EMC90557.1 - 2.6e-06 27.8 24.0 0.027 14.9 0.8 4.8 1 1 4 5 5 5 3 C2HE / C2H2 / C2HC zinc-binding finger zinc_ribbon_15 PF17032.5 EMC90557.1 - 0.012 16.4 1.2 0.012 16.4 1.2 2.9 2 1 0 2 2 1 0 zinc-ribbon family zf-C2H2_2 PF12756.7 EMC90557.1 - 0.015 15.6 22.9 1.5 9.2 0.6 4.9 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 EMC90557.1 - 0.029 14.5 20.3 0.45 10.7 0.6 4.3 1 1 3 4 4 4 0 Zinc ribbon domain zf-C2HC_2 PF13913.6 EMC90557.1 - 0.051 13.5 13.7 0.92 9.5 0.6 4.4 4 0 0 4 4 4 0 zinc-finger of a C2HC-type zf-AN1 PF01428.16 EMC90557.1 - 0.081 13.1 21.2 4.4 7.5 1.7 5.2 5 0 0 5 5 5 0 AN1-like Zinc finger zf-BED PF02892.15 EMC90557.1 - 0.094 12.8 28.8 0.17 11.9 1.0 5.1 2 2 3 5 5 5 0 BED zinc finger PyrI_C PF02748.15 EMC90557.1 - 0.22 11.5 15.1 1 9.3 1.9 4.6 5 0 0 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-CHY PF05495.12 EMC90557.1 - 5 7.7 27.6 2.9 8.4 6.8 2.6 1 1 1 2 2 2 0 CHY zinc finger zf_ZIC PF18366.1 EMC90557.1 - 5.6 7.2 13.8 5.2 7.3 1.4 4.6 1 1 4 5 5 5 0 Zic proteins zinc finger domain Spt46 PF17734.1 EMC90557.1 - 6.1 6.6 17.0 1.6 8.5 4.5 3.5 1 1 2 4 4 4 0 Spermatogenesis-associated protein 46 DUF4764 PF15961.5 EMC90557.1 - 6.6 5.3 9.9 3.9 6.0 0.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4764) zf-C2H2_11 PF16622.5 EMC90557.1 - 6.6 6.6 29.1 6.8 6.5 0.6 5.2 5 0 0 5 5 5 0 zinc-finger C2H2-type TMEM189_B_dmain PF10520.9 EMC90558.1 - 3.2e-29 102.3 2.0 5e-29 101.6 2.0 1.3 1 0 0 1 1 1 1 B domain of TMEM189, localisation domain UQ_con PF00179.26 EMC90558.1 - 6.6e-18 64.7 0.0 1e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EMC90558.1 - 0.038 14.3 0.0 0.054 13.8 0.0 1.4 1 0 0 1 1 1 0 RWD domain RRM_1 PF00076.22 EMC90559.1 - 1.6e-12 47.0 0.0 3.3e-12 46.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMC90559.1 - 0.011 15.3 0.0 0.02 14.5 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4349 PF14257.6 EMC90559.1 - 0.036 13.5 1.2 0.055 12.9 1.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) PilO PF04350.13 EMC90559.1 - 0.11 12.7 1.0 0.2 11.8 1.0 1.5 1 0 0 1 1 1 0 Pilus assembly protein, PilO RP-C_C PF11800.8 EMC90559.1 - 0.23 11.5 2.6 0.36 10.9 2.6 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region Perilipin PF03036.16 EMC90561.1 - 2.2e-47 162.0 2.7 2.4e-47 161.8 2.7 1.0 1 0 0 1 1 1 1 Perilipin family EspB PF05802.11 EMC90561.1 - 0.00031 20.8 0.3 0.00035 20.6 0.3 1.0 1 0 0 1 1 1 1 Enterobacterial EspB protein Snf7 PF03357.21 EMC90562.1 - 8.7e-46 155.7 9.0 8.7e-46 155.7 9.0 1.8 2 0 0 2 2 2 1 Snf7 SYF2 PF08231.12 EMC90562.1 - 0.0045 17.4 6.0 0.0067 16.8 6.0 1.5 1 1 0 1 1 1 1 SYF2 splicing factor zf-C2H2 PF00096.26 EMC90563.1 - 1e-36 123.4 111.7 3.3e-05 24.1 1.3 12.4 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC90563.1 - 6.4e-32 108.6 97.6 7e-09 35.7 0.0 13.3 13 0 0 13 13 13 10 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC90563.1 - 2.9e-28 96.1 107.7 0.00083 20.0 0.4 12.8 13 0 0 13 13 12 10 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC90563.1 - 1.6e-14 53.7 79.4 0.0085 16.4 2.6 11.7 10 1 1 11 11 11 9 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMC90563.1 - 8.5e-06 25.6 89.0 4.7e-05 23.3 2.4 12.2 12 0 0 12 12 12 6 C2H2-type zinc finger zf-met PF12874.7 EMC90563.1 - 2.8e-05 24.3 70.1 0.88 10.0 0.3 11.5 11 0 0 11 11 11 7 Zinc-finger of C2H2 type BolA PF01722.18 EMC90563.1 - 5.9e-05 23.3 14.6 0.0082 16.4 0.1 5.2 4 2 1 5 5 5 2 BolA-like protein zf-C2H2_2 PF12756.7 EMC90563.1 - 0.00022 21.5 64.9 0.2 12.0 0.5 8.4 2 2 7 9 9 9 5 C2H2 type zinc-finger (2 copies) GAGA PF09237.11 EMC90563.1 - 0.0012 18.6 10.3 1.5 8.6 0.8 4.2 3 0 0 3 3 3 3 GAGA factor zf-C2HE PF16278.5 EMC90563.1 - 0.01 16.3 4.9 0.028 14.9 1.5 10.0 6 5 3 9 9 9 0 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_5 PF13909.6 EMC90563.1 - 0.018 14.8 0.1 0.018 14.8 0.1 10.9 11 2 0 11 11 11 0 C2H2-type zinc-finger domain zf-CHCC PF10276.9 EMC90563.1 - 0.37 10.9 8.6 18 5.5 0.1 5.0 4 0 0 4 4 4 0 Zinc-finger domain Tim17 PF02466.19 EMC90564.1 - 6.6e-13 49.0 0.7 1.2e-12 48.2 0.6 1.4 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family E2F_CC-MB PF16421.5 EMC90565.1 - 3.4e-20 72.2 0.1 5.4e-20 71.6 0.1 1.3 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain EF-hand_5 PF13202.6 EMC90566.1 - 1.5e-07 30.6 4.7 4.3e-06 26.0 1.2 2.6 1 1 1 2 2 2 2 EF hand EF-hand_1 PF00036.32 EMC90566.1 - 4.7e-07 28.9 3.8 1.5e-06 27.3 1.4 2.4 1 1 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 EMC90566.1 - 2e-06 27.6 2.3 4.9e-05 23.1 0.6 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EMC90566.1 - 7.6e-06 25.5 2.9 0.00029 20.5 1.0 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 EMC90566.1 - 3.8e-05 24.1 0.0 0.00053 20.4 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair Spore_III_AB PF09548.10 EMC90566.1 - 0.0064 16.6 2.6 0.0092 16.1 0.9 1.9 2 0 0 2 2 2 1 Stage III sporulation protein AB (spore_III_AB) ABM PF03992.16 EMC90566.1 - 0.016 15.3 0.0 0.039 14.1 0.0 1.6 1 0 0 1 1 1 0 Antibiotic biosynthesis monooxygenase Baculo_PEP_C PF04513.12 EMC90566.1 - 0.37 10.8 1.3 0.49 10.4 0.3 1.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus HMG_box PF00505.19 EMC90567.1 - 6.2e-11 42.6 0.0 1.3e-10 41.5 0.0 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMC90567.1 - 1.7e-09 38.1 0.0 3.3e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 HMG-box domain IMUP PF15761.5 EMC90567.1 - 0.026 15.2 10.5 0.076 13.7 10.5 1.8 1 0 0 1 1 1 0 Immortalisation up-regulated protein YABBY PF04690.13 EMC90567.1 - 0.027 15.0 0.7 0.044 14.4 0.7 1.4 1 0 0 1 1 1 0 YABBY protein Mitofilin PF09731.9 EMC90567.1 - 0.79 8.5 5.5 1 8.1 5.5 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Glyco_hydro_47 PF01532.20 EMC90568.1 - 4.3e-115 385.2 0.0 7.6e-115 384.4 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 DUF3689 PF12463.8 EMC90569.1 - 7.8e-142 472.1 15.6 1.3e-141 471.4 15.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3689) Myosin_head PF00063.21 EMC90570.1 - 1.6e-288 958.6 0.8 1.6e-288 958.6 0.8 3.3 3 0 0 3 3 2 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 EMC90570.1 - 1.6e-169 566.0 267.3 2.3e-169 565.5 267.3 1.2 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.19 EMC90570.1 - 2e-13 49.9 6.8 4.8e-13 48.7 6.8 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Filament PF00038.21 EMC90570.1 - 5e-06 26.3 38.0 5e-06 26.3 38.0 9.6 1 1 5 7 7 7 4 Intermediate filament protein FPP PF05911.11 EMC90570.1 - 0.0011 17.3 6.7 0.0011 17.3 6.7 8.5 1 1 8 9 9 9 1 Filament-like plant protein, long coiled-coil Sec2p PF06428.11 EMC90570.1 - 0.0016 18.4 7.7 0.0016 18.4 7.7 17.2 1 1 17 18 18 13 2 GDP/GTP exchange factor Sec2p IQ PF00612.27 EMC90570.1 - 0.023 14.5 1.4 0.17 11.7 0.3 2.8 2 0 0 2 2 2 0 IQ calmodulin-binding motif TsaE PF02367.17 EMC90570.1 - 0.067 13.2 0.6 5.2 7.1 0.0 3.4 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 EMC90570.1 - 0.13 12.6 0.0 0.13 12.6 0.0 7.3 4 2 2 7 7 7 0 AAA domain AAA_16 PF13191.6 EMC90570.1 - 0.51 10.7 0.0 0.51 10.7 0.0 7.4 2 1 2 4 4 2 0 AAA ATPase domain DUF1664 PF07889.12 EMC90570.1 - 1.7 8.7 143.8 0.59 10.2 1.7 13.5 1 1 12 15 15 15 0 Protein of unknown function (DUF1664) ATG16 PF08614.11 EMC90570.1 - 7.4 6.7 252.6 0.2 11.9 24.0 10.2 1 1 8 9 9 8 0 Autophagy protein 16 (ATG16) GSH_synth_ATP PF03917.17 EMC90571.1 - 1.1e-125 419.4 0.0 1.2e-125 419.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 EMC90571.1 - 3e-34 117.5 0.2 6.8e-34 116.4 0.2 1.6 1 0 0 1 1 1 1 Eukaryotic glutathione synthase MAM PF00629.23 EMC90573.1 - 1.3e-29 103.1 0.0 2.4e-29 102.3 0.0 1.5 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu fn3 PF00041.21 EMC90573.1 - 1.7e-16 60.4 1.3 1.7e-07 31.5 0.0 3.5 3 0 0 3 3 3 3 Fibronectin type III domain DUF872 PF05915.12 EMC90573.1 - 0.088 13.0 0.1 0.66 10.2 0.0 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) Y_phosphatase PF00102.27 EMC90574.1 - 8.2e-148 490.3 1.6 4.3e-81 271.9 0.1 2.4 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 EMC90574.1 - 1.8e-09 37.5 0.1 0.0011 18.8 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain fn3 PF00041.21 EMC90574.1 - 1.6e-07 31.5 0.0 0.0008 19.7 0.0 3.8 2 1 1 3 3 3 2 Fibronectin type III domain Y_phosphatase3 PF13350.6 EMC90574.1 - 2.8e-05 24.2 0.0 0.015 15.2 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EMC90574.1 - 5.2e-05 23.4 0.0 0.51 10.4 0.0 2.8 2 0 0 2 2 2 2 Inositol hexakisphosphate EphA2_TM PF14575.6 EMC90574.1 - 0.017 16.0 0.0 0.042 14.7 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain PTP_tm PF18861.1 EMC90574.1 - 0.035 14.1 0.0 0.082 12.9 0.0 1.6 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J DctM PF06808.12 EMC90574.1 - 0.17 10.6 0.1 0.26 10.1 0.1 1.1 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporter, DctM component ABC_transp_aux PF09822.9 EMC90576.1 - 4.1e-08 33.0 0.0 6.6e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 ABC-type uncharacterized transport system DDOST_48kD PF03345.14 EMC90576.1 - 0.00051 19.0 0.0 0.044 12.6 0.0 2.1 1 1 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Pkinase PF00069.25 EMC90577.1 - 1.4e-68 231.1 0.0 1.7e-68 230.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC90577.1 - 3.1e-35 121.7 0.0 3.8e-35 121.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EMC90577.1 - 3.5e-06 27.6 0.2 7.1e-06 26.6 0.2 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 EMC90577.1 - 1.1e-05 24.9 0.1 3.7e-05 23.2 0.1 1.8 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMC90577.1 - 0.0015 17.9 0.0 0.0025 17.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EMC90577.1 - 0.0093 15.6 0.0 0.65 9.6 0.0 2.2 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 EMC90577.1 - 0.13 11.2 0.0 0.18 10.7 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Aa_trans PF01490.18 EMC90578.1 - 1.6e-93 313.7 19.4 2e-93 313.3 19.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein RhoGAP PF00620.27 EMC90579.1 - 6.3e-43 146.2 0.3 6.3e-43 146.2 0.3 2.1 2 1 0 2 2 2 1 RhoGAP domain Actin PF00022.19 EMC90580.1 - 1.6e-41 142.3 0.0 9.2e-25 87.1 0.0 2.2 2 1 0 2 2 2 2 Actin DUF1542 PF07564.11 EMC90580.1 - 0.056 13.6 3.1 0.29 11.3 0.3 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) DUF2777 PF10949.8 EMC90580.1 - 0.084 12.5 1.6 0.16 11.7 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2777) DUF4265 PF14085.6 EMC90580.1 - 0.086 12.8 0.1 16 5.5 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4265) Ank_2 PF12796.7 EMC90581.1 - 9.3e-32 109.5 5.4 3.5e-17 62.8 2.3 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC90581.1 - 1e-30 105.7 8.1 5.4e-14 52.4 0.5 5.9 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 EMC90581.1 - 5.7e-27 92.9 14.2 2.7e-08 33.9 0.6 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EMC90581.1 - 1.6e-24 85.6 10.6 7.6e-12 45.2 1.9 4.6 2 2 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMC90581.1 - 3.8e-20 69.9 8.9 0.00011 22.4 0.2 5.5 5 0 0 5 5 5 4 Ankyrin repeat DUF4337 PF14235.6 EMC90581.1 - 0.097 12.8 3.9 0.21 11.7 3.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF4770 PF15994.5 EMC90581.1 - 0.12 12.6 1.7 0.24 11.6 1.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) FAM83 PF07894.12 EMC90582.1 - 5.2e-54 183.6 0.1 8e-54 183.0 0.1 1.3 1 0 0 1 1 1 1 FAM83 A-H PLDc_2 PF13091.6 EMC90582.1 - 9.9e-05 22.2 0.0 0.0002 21.3 0.0 1.4 1 0 0 1 1 1 1 PLD-like domain FAM83 PF07894.12 EMC90583.1 - 2.3e-38 132.3 0.7 2.8e-25 89.4 0.6 2.1 1 1 1 2 2 2 2 FAM83 A-H PLDc_2 PF13091.6 EMC90583.1 - 0.0022 17.9 0.1 0.0074 16.2 0.1 1.8 1 1 0 1 1 1 1 PLD-like domain HA2 PF04408.23 EMC90584.1 - 1.6e-20 73.4 0.1 4.3e-20 72.0 0.1 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EMC90584.1 - 1.7e-19 70.0 0.0 3.5e-19 68.9 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EMC90584.1 - 3.2e-10 40.3 0.1 7.3e-10 39.2 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ABC_tran PF00005.27 EMC90584.1 - 0.00015 22.3 0.2 0.037 14.5 0.1 2.5 1 1 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 EMC90584.1 - 0.00037 20.8 0.2 0.0015 18.8 0.1 2.1 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EMC90584.1 - 0.017 14.8 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EMC90584.1 - 0.04 14.3 0.0 0.18 12.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EMC90584.1 - 0.084 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region bZIP_Maf PF03131.17 EMC90585.1 - 3.9e-35 120.2 11.8 3.9e-35 120.2 11.8 2.0 2 0 0 2 2 2 1 bZIP Maf transcription factor Maf_N PF08383.11 EMC90585.1 - 5.2e-22 77.3 1.3 2.2e-21 75.3 1.3 2.2 1 0 0 1 1 1 1 Maf N-terminal region KASH_CCD PF14662.6 EMC90585.1 - 0.00028 20.8 3.4 0.00047 20.0 3.4 1.4 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH HOOK PF05622.12 EMC90585.1 - 0.00045 18.5 6.7 0.00062 18.1 6.7 1.1 1 0 0 1 1 1 1 HOOK protein bZIP_1 PF00170.21 EMC90585.1 - 0.0021 18.1 12.2 0.0037 17.3 12.2 1.4 1 0 0 1 1 1 1 bZIP transcription factor APC_N_CC PF16689.5 EMC90585.1 - 0.0068 16.5 1.6 0.019 15.0 1.6 1.8 1 0 0 1 1 1 1 Coiled-coil N-terminus of APC, dimerisation domain DUF2353 PF09789.9 EMC90585.1 - 0.012 15.0 7.0 0.025 14.0 7.0 1.5 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) DUF1192 PF06698.11 EMC90585.1 - 0.019 15.0 0.6 6.2 7.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) FAM76 PF16046.5 EMC90585.1 - 0.031 13.6 13.5 0.045 13.1 13.5 1.1 1 0 0 1 1 1 0 FAM76 protein bZIP_2 PF07716.15 EMC90585.1 - 0.044 13.9 10.7 0.09 12.9 10.7 1.5 1 0 0 1 1 1 0 Basic region leucine zipper Spc24 PF08286.11 EMC90585.1 - 0.076 13.3 0.6 0.22 11.8 0.6 1.7 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 CRA PF06589.11 EMC90585.1 - 0.45 10.6 4.1 0.85 9.7 4.1 1.6 1 1 0 1 1 1 0 Circumsporozoite-related antigen (CRA) UPF0449 PF15136.6 EMC90585.1 - 0.51 10.8 9.3 12 6.4 8.6 3.0 2 1 1 3 3 3 0 Uncharacterised protein family UPF0449 MbeD_MobD PF04899.12 EMC90585.1 - 0.52 10.5 7.0 0.12 12.5 2.6 2.3 2 0 0 2 2 2 0 MbeD/MobD like JIP_LZII PF16471.5 EMC90585.1 - 0.54 10.5 5.9 0.18 12.0 2.7 1.8 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II Seryl_tRNA_N PF02403.22 EMC90585.1 - 1.8 8.8 7.1 5.1 7.4 7.1 1.7 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain ZapB PF06005.12 EMC90585.1 - 2.9 8.4 10.4 2.8 8.5 6.8 2.4 1 1 1 2 2 2 0 Cell division protein ZapB Topoisom_I PF01028.20 EMC90586.1 - 3.8e-103 343.7 3.7 3.8e-103 343.7 3.7 2.7 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 EMC90586.1 - 4.8e-101 336.7 7.7 4.8e-101 336.7 7.7 5.3 4 1 0 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 EMC90586.1 - 1.3e-33 114.8 0.5 1.3e-33 114.8 0.5 3.1 2 0 0 2 2 2 1 C-terminal topoisomerase domain Arg_decarbox_C PF17944.1 EMC90586.1 - 0.26 11.9 1.5 1.1 9.8 1.5 2.2 1 0 0 1 1 1 0 Arginine decarboxylase C-terminal helical extension PI-PLC-X PF00388.19 EMC90587.1 - 1.1e-65 219.6 0.3 3e-65 218.2 0.0 1.9 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain SH2 PF00017.24 EMC90587.1 - 8.5e-48 160.4 1.0 2e-24 85.4 0.0 3.3 3 0 0 3 3 3 2 SH2 domain PI-PLC-Y PF00387.19 EMC90587.1 - 2.8e-40 137.2 0.0 6.8e-40 136.0 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 PF00018.28 EMC90587.1 - 4.1e-16 58.3 0.6 1.2e-15 56.9 0.6 1.8 1 0 0 1 1 1 1 SH3 domain C2 PF00168.30 EMC90587.1 - 2.5e-14 53.4 0.0 6.7e-14 52.0 0.0 1.7 1 0 0 1 1 1 1 C2 domain PH PF00169.29 EMC90587.1 - 2.7e-11 43.9 0.1 0.029 14.9 0.0 4.1 4 0 0 4 4 3 3 PH domain SH3_9 PF14604.6 EMC90587.1 - 9e-11 41.5 0.6 2.7e-10 40.0 0.1 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EMC90587.1 - 6.6e-09 35.3 0.1 1.4e-08 34.3 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain GDPD PF03009.17 EMC90587.1 - 0.00047 20.0 0.0 0.002 17.9 0.0 2.0 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family PH_12 PF16457.5 EMC90587.1 - 0.0057 17.2 0.0 0.016 15.8 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain EF-hand_6 PF13405.6 EMC90587.1 - 0.15 12.0 0.0 3.8 7.7 0.0 2.9 2 0 0 2 2 2 0 EF-hand domain LNS2 PF08235.13 EMC90588.1 - 8.8e-106 352.5 0.0 1.4e-105 351.8 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 EMC90588.1 - 2.9e-43 146.0 0.0 5.1e-43 145.2 0.0 1.4 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.5 EMC90588.1 - 4.1e-33 113.5 0.0 8e-33 112.6 0.0 1.5 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain Dishevelled PF02377.15 EMC90588.1 - 0.019 15.5 0.4 0.039 14.4 0.4 1.5 1 0 0 1 1 1 0 Dishevelled specific domain EMI PF07546.13 EMC90589.1 - 2.1e-16 60.4 5.9 2.1e-16 60.4 5.9 2.1 2 0 0 2 2 1 1 EMI domain DUF1664 PF07889.12 EMC90589.1 - 7e-05 22.9 18.3 0.02 14.9 1.0 7.0 3 1 2 7 7 7 2 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 EMC90589.1 - 0.0001 22.7 12.4 8 7.0 0.3 7.8 6 1 2 9 9 8 0 Nucleopolyhedrovirus P10 protein Spc7 PF08317.11 EMC90589.1 - 0.00031 19.7 18.7 0.12 11.2 0.9 4.3 1 1 2 4 4 4 3 Spc7 kinetochore protein CorA PF01544.18 EMC90589.1 - 0.00055 19.3 4.4 0.00055 19.3 4.4 3.3 3 2 0 3 3 3 1 CorA-like Mg2+ transporter protein MIP-T3_C PF17749.1 EMC90589.1 - 0.00096 19.1 14.0 1.2 9.1 0.2 5.3 4 1 2 6 6 5 2 Microtubule-binding protein MIP-T3 C-terminal region DUF5082 PF16888.5 EMC90589.1 - 0.00096 19.4 18.2 4.5 7.6 7.3 6.6 4 2 1 5 5 5 1 Domain of unknown function (DUF5082) Baculo_PEP_C PF04513.12 EMC90589.1 - 0.0016 18.5 17.6 7.1 6.7 3.0 6.5 2 1 4 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus Trimer_CC PF08954.11 EMC90589.1 - 0.0028 17.2 5.8 0.67 9.6 0.2 3.8 3 0 0 3 3 3 2 Trimerisation motif Fzo_mitofusin PF04799.13 EMC90589.1 - 0.004 16.7 13.7 0.012 15.2 3.2 4.7 3 1 1 4 4 4 1 fzo-like conserved region Golgin_A5 PF09787.9 EMC90589.1 - 0.0049 16.4 2.5 0.0049 16.4 2.5 3.5 3 1 1 4 4 3 1 Golgin subfamily A member 5 TPR_MLP1_2 PF07926.12 EMC90589.1 - 0.01 15.9 3.5 0.01 15.9 3.5 5.4 5 2 2 7 7 6 0 TPR/MLP1/MLP2-like protein Exonuc_VII_L PF02601.15 EMC90589.1 - 0.011 15.3 8.9 0.4 10.2 0.2 3.2 2 1 0 2 2 2 0 Exonuclease VII, large subunit Sugarporin_N PF11471.8 EMC90589.1 - 0.035 14.1 0.1 0.17 11.9 0.1 2.2 2 0 0 2 2 1 0 Maltoporin periplasmic N-terminal extension Fib_alpha PF08702.10 EMC90589.1 - 0.045 13.9 24.0 0.032 14.4 3.1 5.8 3 2 2 5 5 5 0 Fibrinogen alpha/beta chain family WXG100 PF06013.12 EMC90589.1 - 0.046 14.0 4.9 3 8.1 0.0 5.8 7 2 0 7 7 5 0 Proteins of 100 residues with WXG OmpH PF03938.14 EMC90589.1 - 0.073 13.4 3.2 48 4.3 0.0 4.0 4 0 0 4 4 4 0 Outer membrane protein (OmpH-like) PMEI PF04043.15 EMC90589.1 - 0.12 12.7 7.1 8.1 6.8 0.1 4.0 3 1 0 4 4 4 0 Plant invertase/pectin methylesterase inhibitor TACC_C PF05010.14 EMC90589.1 - 0.13 12.1 12.2 0.69 9.7 0.9 3.2 2 1 1 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal ApoO PF09769.9 EMC90589.1 - 0.16 11.9 0.4 42 4.1 0.1 4.0 5 0 0 5 5 4 0 Apolipoprotein O Corona_S2 PF01601.16 EMC90589.1 - 0.29 9.6 6.7 0.93 7.9 0.3 3.1 2 2 2 4 4 4 0 Coronavirus S2 glycoprotein HCMV_UL139 PF12507.8 EMC90589.1 - 0.74 10.2 7.4 14 6.1 0.1 4.0 4 1 1 5 5 5 0 Human Cytomegalovirus UL139 protein COG2 PF06148.11 EMC90589.1 - 1.5 8.9 16.4 0.48 10.5 0.3 5.3 5 2 0 5 5 4 0 COG (conserved oligomeric Golgi) complex component, COG2 Rootletin PF15035.6 EMC90589.1 - 2.4 8.2 20.9 3.8e+02 1.0 0.0 3.9 2 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Occludin_ELL PF07303.13 EMC90589.1 - 2.7 8.7 5.9 5.2 7.8 0.3 4.2 5 1 0 5 5 3 0 Occludin homology domain Spc24 PF08286.11 EMC90589.1 - 4.2 7.7 12.0 5.7 7.2 0.3 5.0 3 1 1 4 4 4 0 Spc24 subunit of Ndc80 Bacillus_HBL PF05791.11 EMC90589.1 - 4.5 7.0 10.1 18 5.1 1.7 4.4 2 1 0 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) Tropomyosin PF00261.20 EMC90589.1 - 6.2 6.1 16.3 1 8.7 4.5 3.8 1 1 0 2 2 2 0 Tropomyosin Jnk-SapK_ap_N PF09744.9 EMC90589.1 - 6.5 7.0 20.0 2.5 8.3 3.8 4.1 3 1 1 4 4 4 0 JNK_SAPK-associated protein-1 UPF0449 PF15136.6 EMC90589.1 - 9.8 6.7 9.6 3.4 8.2 0.3 3.5 2 1 0 3 3 3 0 Uncharacterised protein family UPF0449 Ribophorin_II PF05817.14 EMC90590.1 - 1.3e-216 721.1 7.2 1.4e-216 720.9 7.2 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II Hormone_2 PF00123.20 EMC90591.1 - 1.6e-14 53.5 0.3 8.2e-14 51.2 0.1 2.1 2 0 0 2 2 2 1 Peptide hormone UPF0239 PF06783.11 EMC90592.1 - 3.4e-37 126.5 0.1 3.8e-37 126.3 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0239) MscL PF01741.18 EMC90592.1 - 0.1 12.9 0.0 0.11 12.8 0.0 1.1 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL BC10 PF06726.12 EMC90593.1 - 5.3e-27 93.8 10.2 6.8e-27 93.5 10.2 1.2 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 Dysbindin PF04440.16 EMC90594.1 - 3.4e-45 153.8 7.0 3.4e-45 153.8 7.0 1.4 1 1 1 2 2 2 1 Dysbindin (Dystrobrevin binding protein 1) SYS1 PF09801.9 EMC90595.1 - 1.5e-35 122.5 2.9 1.6e-35 122.3 2.9 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network Syndecan PF01034.20 EMC90596.1 - 8.5e-25 86.5 0.2 1.2e-24 86.0 0.2 1.2 1 0 0 1 1 1 1 Syndecan domain Protocadherin PF08374.11 EMC90596.1 - 0.011 15.8 0.0 0.013 15.5 0.0 1.1 1 0 0 1 1 1 0 Protocadherin BTD PF09270.10 EMC90597.1 - 6e-67 224.6 0.0 1e-66 223.9 0.0 1.4 1 0 0 1 1 1 1 Beta-trefoil DNA-binding domain LAG1-DNAbind PF09271.11 EMC90597.1 - 3.5e-44 151.1 0.6 1.2e-43 149.4 0.6 1.8 1 1 0 1 1 1 1 LAG1, DNA binding VWA PF00092.28 EMC90598.1 - 9.9e-102 338.5 0.2 1e-52 178.9 0.0 2.1 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 EMC90598.1 - 3.4e-38 130.6 0.1 1.2e-17 64.5 0.1 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain FXa_inhibition PF14670.6 EMC90598.1 - 5.9e-31 106.4 62.0 4.5e-09 36.4 9.0 4.5 4 0 0 4 4 4 4 Coagulation Factor Xa inhibitory site cEGF PF12662.7 EMC90598.1 - 4.6e-22 77.6 29.7 6.5e-08 32.4 1.7 4.9 4 0 0 4 4 4 4 Complement Clr-like EGF-like EGF_CA PF07645.15 EMC90598.1 - 2e-19 69.5 49.9 6.7e-07 29.4 5.8 4.4 4 0 0 4 4 4 4 Calcium-binding EGF domain Matrilin_ccoil PF10393.9 EMC90598.1 - 4.6e-12 45.6 0.2 1.2e-11 44.2 0.2 1.7 1 0 0 1 1 1 1 Trimeric coiled-coil oligomerisation domain of matrilin EGF PF00008.27 EMC90598.1 - 5.9e-11 42.5 50.4 0.001 19.3 6.5 4.7 4 0 0 4 4 4 4 EGF-like domain VWA_3 PF13768.6 EMC90598.1 - 3e-07 30.5 0.1 0.011 15.7 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain hEGF PF12661.7 EMC90598.1 - 8.9e-05 23.0 38.3 0.082 13.6 2.5 5.1 4 0 0 4 4 4 3 Human growth factor-like EGF EGF_3 PF12947.7 EMC90598.1 - 0.00057 20.0 51.0 0.018 15.2 7.7 4.7 4 0 0 4 4 4 2 EGF domain ClpB_D2-small PF10431.9 EMC90598.1 - 0.074 13.1 0.0 4.5 7.4 0.0 2.5 2 0 0 2 2 2 0 C-terminal, D2-small domain, of ClpB protein Ion_trans PF00520.31 EMC90599.1 - 3.6e-45 154.1 0.6 4.7e-45 153.7 0.6 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 EMC90599.1 - 2e-29 101.8 0.1 4.3e-29 100.7 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 EMC90599.1 - 2.2e-10 40.4 4.6 2.2e-10 40.4 4.6 2.1 2 0 0 2 2 2 1 Ion channel RhoGAP PF00620.27 EMC90600.1 - 2.9e-11 43.4 0.0 4.4e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain Ten_N PF06484.12 EMC90601.1 - 7e-31 108.4 7.0 7.7e-31 108.3 7.0 1.0 1 0 0 1 1 1 1 Teneurin Intracellular Region tRNA-synt_2 PF00152.20 EMC90602.1 - 8.9e-98 327.2 0.0 1.1e-97 327.0 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EMC90602.1 - 2.3e-08 33.9 0.0 4e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EMC90602.1 - 0.0017 17.9 0.8 1.7 8.1 0.3 2.6 2 1 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.25 EMC90602.1 - 0.12 12.3 0.1 0.42 10.6 0.0 1.9 2 0 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) PH PF00169.29 EMC90603.1 - 6e-19 68.5 0.2 3.5e-18 66.0 0.2 2.4 3 0 0 3 3 3 1 PH domain PH_11 PF15413.6 EMC90603.1 - 2.9e-05 24.4 0.9 0.00021 21.6 0.9 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.10 EMC90603.1 - 0.2 12.0 0.0 0.38 11.1 0.0 1.3 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PH_3 PF14593.6 EMC90603.1 - 0.22 11.6 0.3 0.65 10.1 0.3 1.8 1 1 0 1 1 1 0 PH domain UCH PF00443.29 EMC90604.1 - 1.4e-43 149.3 0.0 3e-43 148.2 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMC90604.1 - 1.2e-25 90.8 0.0 4.3e-25 89.0 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DDR PF08841.10 EMC90604.1 - 0.086 11.8 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain BTB_2 PF02214.22 EMC90605.1 - 2.5e-21 75.8 0.0 5.5e-21 74.7 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 EMC90605.1 - 6.9e-05 22.9 0.0 0.00013 22.0 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain NDUF_C2 PF06374.11 EMC90606.1 - 3.1e-26 91.7 0.1 3.5e-26 91.5 0.1 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) Spot_14 PF07084.12 EMC90607.1 - 1.2e-27 96.9 0.1 1.4e-27 96.7 0.1 1.0 1 0 0 1 1 1 1 Thyroid hormone-inducible hepatic protein Spot 14 Spot_14 PF07084.12 EMC90608.1 - 2.3e-27 96.0 0.2 2.7e-27 95.8 0.2 1.0 1 0 0 1 1 1 1 Thyroid hormone-inducible hepatic protein Spot 14 Spot_14 PF07084.12 EMC90609.1 - 1.8e-25 89.9 0.1 2.2e-25 89.6 0.1 1.0 1 0 0 1 1 1 1 Thyroid hormone-inducible hepatic protein Spot 14 Med2 PF11214.8 EMC90609.1 - 0.0076 16.4 0.7 0.011 15.9 0.7 1.3 1 0 0 1 1 1 1 Mediator complex subunit 2 BTB_2 PF02214.22 EMC90610.1 - 3.3e-16 59.4 0.0 5.3e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain TNF PF00229.18 EMC90610.1 - 0.099 12.6 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 TNF(Tumour Necrosis Factor) family HEAT PF02985.22 EMC90611.1 - 1e-20 72.0 6.9 0.021 15.0 0.0 8.7 8 0 0 8 8 8 5 HEAT repeat HEAT_2 PF13646.6 EMC90611.1 - 1.1e-15 57.8 5.1 1.2e-05 25.6 0.1 5.0 4 1 2 6 6 6 2 HEAT repeats Adaptin_N PF01602.20 EMC90611.1 - 4.7e-10 38.6 4.9 0.00026 19.7 0.1 3.2 2 1 1 3 3 3 2 Adaptin N terminal region Cnd1 PF12717.7 EMC90611.1 - 7.1e-10 39.2 4.7 0.0023 18.0 0.5 4.3 2 1 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EMC90611.1 - 2.4e-08 34.5 1.0 0.00023 21.7 0.1 4.6 4 2 1 5 5 4 2 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EMC90611.1 - 4.1e-06 26.5 0.3 4.2 6.9 0.1 4.7 2 2 3 5 5 5 3 CLASP N terminal Cohesin_HEAT PF12765.7 EMC90611.1 - 0.00017 21.8 0.5 0.19 12.0 0.0 4.4 5 0 0 5 5 5 1 HEAT repeat associated with sister chromatid cohesion Cnd3 PF12719.7 EMC90611.1 - 0.00053 19.3 3.7 0.096 11.9 0.1 2.9 3 0 0 3 3 3 2 Nuclear condensing complex subunits, C-term domain RTP1_C1 PF10363.9 EMC90611.1 - 0.0018 18.5 3.6 0.74 10.0 0.1 4.6 2 1 1 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 DUF445 PF04286.12 EMC90611.1 - 0.0062 16.4 2.4 0.25 11.1 0.3 2.7 1 1 0 2 2 2 1 Protein of unknown function (DUF445) DUF3338 PF11819.8 EMC90611.1 - 0.1 12.6 0.1 1.5 8.8 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3338) HEAT_PBS PF03130.16 EMC90611.1 - 0.14 12.9 0.6 42 5.2 0.0 4.6 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat MMS19_N PF14500.6 EMC90611.1 - 0.37 10.3 4.9 5.1 6.6 0.0 4.0 3 2 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II DUF498 PF04430.14 EMC90612.1 - 2.5e-19 69.4 0.0 2.7e-19 69.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Indigoidine_A PF04227.12 EMC90612.1 - 0.026 13.9 0.0 0.031 13.6 0.0 1.1 1 0 0 1 1 1 0 Indigoidine synthase A like protein HflK_N PF12221.8 EMC90612.1 - 0.052 13.6 0.0 0.083 12.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial membrane protein N terminal Voldacs PF03517.13 EMC90613.1 - 1.8e-28 99.4 1.9 2.6e-28 98.9 1.9 1.2 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling DUF4364 PF14277.6 EMC90613.1 - 0.19 11.4 0.0 0.3 10.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) MIP PF00230.20 EMC90614.1 - 4.5e-11 42.9 8.0 4.8e-10 39.5 8.0 2.1 1 1 0 1 1 1 1 Major intrinsic protein DUF3938 PF13074.6 EMC90614.1 - 2.1 8.6 5.7 1.7 9.0 0.6 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3938) Pkinase PF00069.25 EMC90615.1 - 7.4e-73 245.1 0.0 1.3e-72 244.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC90615.1 - 3.8e-47 160.7 0.0 6e-47 160.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EMC90615.1 - 3.6e-25 88.1 0.0 1.1e-24 86.5 0.0 1.9 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 EMC90615.1 - 1.4e-07 31.1 0.0 0.00024 20.5 0.0 2.4 1 1 1 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EMC90615.1 - 1.6e-06 27.1 0.0 2.4e-06 26.6 0.0 1.6 1 1 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMC90615.1 - 0.0057 16.6 0.0 0.12 12.2 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family DSHCT PF08148.12 EMC90615.1 - 0.016 14.8 0.0 0.032 13.9 0.0 1.5 1 0 0 1 1 1 0 DSHCT (NUC185) domain Kdo PF06293.14 EMC90615.1 - 0.039 13.3 0.0 0.097 12.0 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family GDPD PF03009.17 EMC90616.1 - 3.3e-18 66.3 0.0 4.1e-18 66.0 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family TctB PF07331.11 EMC90616.1 - 0.59 10.4 17.0 55 4.0 17.0 2.4 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family Peptidase_C2 PF00648.21 EMC90617.1 - 1.1e-111 372.6 0.6 1.6e-111 372.1 0.6 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 EMC90617.1 - 3.2e-38 131.2 0.0 5.1e-38 130.5 0.0 1.3 1 0 0 1 1 1 1 Calpain large subunit, domain III C2 PF00168.30 EMC90617.1 - 4.3e-12 46.2 0.0 1.2e-11 44.8 0.0 1.7 1 0 0 1 1 1 1 C2 domain Ceramidase PF05875.12 EMC90619.1 - 4.7e-60 203.2 12.5 5.7e-60 203.0 12.5 1.0 1 0 0 1 1 1 1 Ceramidase DUF2070 PF09843.9 EMC90619.1 - 2.1 6.6 4.9 2.4 6.3 4.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) LRR_8 PF13855.6 EMC90620.1 - 1.1e-38 130.8 23.8 6.6e-13 48.2 1.7 6.8 3 2 4 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 EMC90620.1 - 2.9e-19 68.8 34.8 8.5e-05 22.8 0.5 7.2 4 2 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMC90620.1 - 3.2e-13 48.2 24.2 0.031 14.8 0.3 9.9 10 0 0 10 10 10 4 Leucine Rich Repeat LRR_5 PF13306.6 EMC90620.1 - 1.9e-12 47.3 0.0 7e-05 22.8 0.1 2.5 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 EMC90620.1 - 0.00019 21.2 30.7 0.76 10.0 0.0 8.7 10 0 0 10 10 10 3 Leucine Rich repeat LRR_9 PF14580.6 EMC90620.1 - 0.024 14.1 3.9 6.5 6.2 0.5 3.2 1 1 2 3 3 3 0 Leucine-rich repeat LRRNT PF01462.18 EMC90620.1 - 0.11 12.1 2.4 0.44 10.3 0.5 2.7 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain HNOBA PF07701.14 EMC90621.1 - 1e-06 28.3 1.7 1.1e-06 28.3 1.7 1.0 1 0 0 1 1 1 1 Heme NO binding associated Bac_DNA_binding PF00216.21 EMC90621.1 - 0.067 13.4 0.0 0.077 13.2 0.0 1.1 1 0 0 1 1 1 0 Bacterial DNA-binding protein ENT PF03735.14 EMC90622.1 - 1.5e-28 98.6 0.3 2.9e-28 97.7 0.3 1.5 1 0 0 1 1 1 1 ENT domain DUF4371 PF14291.6 EMC90624.1 - 1.5e-13 50.9 0.3 2.7e-13 50.1 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) Dimer_Tnp_hAT PF05699.14 EMC90624.1 - 2.3e-10 40.1 0.0 5.7e-10 38.9 0.0 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region THAP PF05485.12 EMC90624.1 - 1.1e-08 35.9 0.4 4.1e-08 34.0 0.4 2.1 1 0 0 1 1 1 1 THAP domain L27 PF02828.16 EMC90624.1 - 0.042 13.6 0.0 8.4 6.2 0.0 2.6 2 0 0 2 2 2 0 L27 domain DUF4746 PF15928.5 EMC90624.1 - 0.098 12.1 4.3 0.19 11.1 4.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF659 PF04937.15 EMC90624.1 - 0.25 11.2 2.4 11 5.8 0.0 3.5 5 0 0 5 5 5 0 Protein of unknown function (DUF 659) wnt PF00110.19 EMC90625.1 - 1.8e-107 359.5 16.0 2e-107 359.3 16.0 1.0 1 0 0 1 1 1 1 wnt family Atg14 PF10186.9 EMC90626.1 - 4.2e-19 68.8 8.8 8.3e-19 67.8 8.8 1.4 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 VPS38 PF17649.1 EMC90626.1 - 1.4e-09 37.4 9.6 2.7e-09 36.4 9.6 1.5 1 1 0 1 1 1 1 Vacuolar protein sorting 38 C2 PF00168.30 EMC90626.1 - 0.00029 21.1 0.0 0.0011 19.2 0.0 1.9 2 0 0 2 2 2 1 C2 domain TPR_MLP1_2 PF07926.12 EMC90626.1 - 0.016 15.3 13.2 0.034 14.2 13.2 1.5 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein FapA PF03961.13 EMC90626.1 - 1.4 7.4 10.5 2.3 6.7 10.5 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Rho_Binding PF08912.11 EMC90626.1 - 9.2 7.2 13.0 0.96 10.3 6.3 2.6 1 1 1 2 2 2 0 Rho Binding OmpH PF03938.14 EMC90626.1 - 9.7 6.5 10.0 19 5.6 10.0 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DAGAT PF03982.13 EMC90627.1 - 6.2e-143 475.1 0.0 7.5e-143 474.8 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Acyltransferase PF01553.21 EMC90627.1 - 0.0036 16.9 0.0 0.0073 15.9 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase STOP PF05217.12 EMC90629.1 - 0.54 10.6 5.2 0.75 10.1 0.8 2.9 3 0 0 3 3 3 0 STOP protein Kelch_1 PF01344.25 EMC90630.1 - 9.9e-46 153.1 12.5 3.8e-11 42.4 0.0 7.7 6 2 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 EMC90630.1 - 8.5e-37 124.3 8.0 3.6e-08 33.4 0.1 6.4 4 1 2 6 6 6 5 Kelch motif BACK PF07707.15 EMC90630.1 - 2.3e-33 114.3 0.5 8.9e-33 112.5 0.4 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 EMC90630.1 - 3.2e-30 104.6 0.0 8.4e-30 103.3 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 EMC90630.1 - 1e-27 95.0 6.1 2.3e-05 24.2 0.0 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 EMC90630.1 - 2.2e-20 72.4 10.7 0.00057 19.8 0.0 6.8 5 2 1 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 EMC90630.1 - 1.7e-18 66.4 5.2 0.0011 19.2 0.1 6.2 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EMC90630.1 - 1.6e-13 50.3 9.0 0.029 14.3 0.0 6.2 6 0 0 6 6 6 4 Kelch motif DUF3342 PF11822.8 EMC90630.1 - 0.0003 20.9 0.0 0.0048 17.0 0.0 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF3342) Pput2613-deam PF14427.6 EMC90630.1 - 0.18 11.7 0.0 6 6.8 0.0 2.3 2 0 0 2 2 2 0 Pput_2613-like deaminase GDPD PF03009.17 EMC90631.1 - 1.3e-20 74.2 0.0 8.2e-18 65.1 0.0 2.2 2 0 0 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family DUF2070 PF09843.9 EMC90631.1 - 5.3 5.2 6.8 9 4.5 6.8 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) FixS PF03597.15 EMC90631.1 - 7.1 6.4 7.5 0.61 9.8 0.4 2.8 3 0 0 3 3 3 0 Cytochrome oxidase maturation protein cbb3-type Serpin PF00079.20 EMC90632.1 - 1.1e-100 337.6 0.6 1.2e-100 337.4 0.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Ribosomal_S3_C PF00189.20 EMC90633.1 - 3e-23 82.1 0.2 1.1e-22 80.3 0.2 1.9 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 EMC90633.1 - 1.7e-11 43.8 0.1 2.7e-11 43.1 0.1 1.3 1 0 0 1 1 1 1 KH domain SH3_1 PF00018.28 EMC90634.1 - 1.1e-25 89.0 1.4 2.5e-12 46.2 0.1 2.5 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 EMC90634.1 - 1.2e-24 85.9 1.8 2.5e-13 49.6 0.2 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 EMC90634.1 - 3.4e-21 74.7 0.2 6.7e-11 41.7 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain FCH PF00611.23 EMC90634.1 - 2.5e-05 24.5 2.8 8.4e-05 22.8 0.2 3.0 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain hSH3 PF14603.6 EMC90634.1 - 0.0023 18.3 0.0 0.0079 16.6 0.0 1.9 1 0 0 1 1 1 1 Helically-extended SH3 domain SH3_3 PF08239.11 EMC90634.1 - 0.0024 18.1 0.1 0.007 16.6 0.1 1.8 1 0 0 1 1 1 1 Bacterial SH3 domain H-kinase_dim PF02895.14 EMC90634.1 - 0.24 11.8 3.0 7.2 7.1 0.1 3.3 2 1 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain OmpH PF03938.14 EMC90634.1 - 0.67 10.3 15.9 0.85 10.0 2.2 2.5 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Cob_adeno_trans PF01923.18 EMC90634.1 - 1.3 9.1 5.4 1.9 8.6 0.6 2.5 2 0 0 2 2 2 0 Cobalamin adenosyltransferase DUF3470 PF11953.8 EMC90635.1 - 6.6e-09 35.6 4.5 22 5.2 0.0 8.0 9 0 0 9 9 9 5 Domain of unknown function (DUF3470) RS4NT PF08071.12 EMC90635.1 - 0.11 12.6 13.3 2e+02 2.2 0.0 8.1 10 0 0 10 10 10 0 RS4NT (NUC023) domain 7tm_1 PF00001.21 EMC90637.1 - 1.1e-44 152.7 17.0 1.5e-44 152.3 17.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 EMC90637.1 - 0.0046 16.4 12.7 0.0071 15.7 12.4 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv RELT PF12606.8 EMC90638.1 - 4e-18 64.1 0.4 8.5e-18 63.1 0.4 1.5 1 0 0 1 1 1 1 Tumour necrosis factor receptor superfamily member 19 TCRP1 PF14944.6 EMC90639.1 - 1e-94 317.1 43.7 1.2e-94 316.9 43.7 1.0 1 0 0 1 1 1 1 Tongue Cancer Chemotherapy Resistant Protein 1 Ras PF00071.22 EMC90642.1 - 2e-53 180.3 0.4 2.4e-53 180.1 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC90642.1 - 4.7e-32 110.7 0.2 7.7e-32 110.0 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMC90642.1 - 6.6e-12 45.2 0.8 8.1e-12 44.9 0.8 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMC90642.1 - 6.9e-05 22.5 0.2 0.00014 21.5 0.2 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EMC90642.1 - 0.00091 18.7 0.1 0.0012 18.3 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EMC90642.1 - 0.0064 16.6 0.1 0.012 15.7 0.1 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase TetR_C_16 PF17920.1 EMC90642.1 - 0.15 12.3 0.0 0.25 11.6 0.0 1.2 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Ribosomal_S10 PF00338.22 EMC90643.1 - 1.5e-17 63.6 0.4 2.3e-17 63.0 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein S10p/S20e CarD_CdnL_TRCF PF02559.16 EMC90643.1 - 0.069 13.9 0.1 0.13 13.0 0.1 1.7 1 1 0 1 1 1 0 CarD-like/TRCF domain WD40 PF00400.32 EMC90644.1 - 8.2e-19 67.6 9.0 4.1e-05 24.3 0.0 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat Nucleoporin_N PF08801.11 EMC90644.1 - 0.00029 19.7 0.0 0.056 12.2 0.0 2.6 2 1 1 3 3 3 2 Nup133 N terminal like WD40_like PF17005.5 EMC90644.1 - 0.028 13.8 0.0 1.1 8.5 0.0 2.3 2 0 0 2 2 2 0 WD40-like domain ID PF18543.1 EMC90644.1 - 0.047 13.7 0.0 2 8.5 0.0 2.8 3 0 0 3 3 3 0 Intracellular delivery domain ANAPC4_WD40 PF12894.7 EMC90644.1 - 0.095 13.0 0.0 30 5.0 0.0 3.5 2 2 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Abhydrolase_6 PF12697.7 EMC90645.1 - 8.6e-30 105.0 0.0 2.4e-29 103.5 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EMC90645.1 - 7.2e-14 52.0 0.0 2.1e-13 50.5 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMC90645.1 - 1.9e-10 40.4 0.0 3.6e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EMC90645.1 - 0.00013 22.2 0.0 0.00021 21.5 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 EMC90645.1 - 0.003 17.3 0.1 0.006 16.3 0.1 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_3 PF07859.13 EMC90645.1 - 0.0036 17.2 0.0 0.0057 16.5 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EMC90645.1 - 0.0087 15.9 0.9 3.4 7.4 0.1 2.4 1 1 1 2 2 2 2 Phospholipase/Carboxylesterase Esterase PF00756.20 EMC90645.1 - 0.0095 15.6 0.1 0.043 13.4 0.1 1.9 1 1 0 1 1 1 1 Putative esterase Lipase_3 PF01764.25 EMC90645.1 - 0.028 14.3 0.0 0.065 13.1 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) 2OG-FeII_Oxy_3 PF13640.6 EMC90646.1 - 4.4e-16 59.6 0.1 6.9e-16 58.9 0.1 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SPC25 PF06703.11 EMC90648.1 - 4.6e-31 107.8 0.2 1.1e-30 106.5 0.2 1.5 1 1 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF2975 PF11188.8 EMC90648.1 - 1.1 9.2 4.9 11 5.9 5.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2975) Sof1 PF04158.14 EMC90649.1 - 4e-35 120.0 10.9 6.5e-35 119.3 10.9 1.3 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 EMC90649.1 - 2.6e-21 75.5 12.6 0.00043 21.0 0.1 6.5 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.11 EMC90649.1 - 7e-07 29.3 0.8 0.00064 19.7 0.0 3.6 2 1 2 4 4 4 1 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 EMC90649.1 - 8.4e-06 26.0 0.0 0.038 14.3 0.0 4.0 2 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMC90649.1 - 0.012 14.6 0.0 1.2 8.0 0.0 2.3 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Mito_carr PF00153.27 EMC90650.1 - 1.2e-61 204.6 3.1 3.3e-22 78.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Collagen PF01391.18 EMC90651.1 - 3.4e-07 29.9 6.9 5.6e-07 29.2 6.9 1.2 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) YuzL PF14115.6 EMC90652.1 - 0.43 11.1 0.2 0.43 11.1 0.2 2.6 3 0 0 3 3 3 0 YuzL-like protein Orn_Arg_deC_N PF02784.16 EMC90653.1 - 1.7e-73 247.0 0.0 2.1e-73 246.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EMC90653.1 - 6.4e-19 68.0 0.0 7.6e-19 67.8 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain zf-C2H2 PF00096.26 EMC90655.1 - 2.3e-12 46.7 22.4 0.00037 20.8 3.3 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC90655.1 - 5e-10 39.3 22.4 2.8e-06 27.5 1.9 3.7 4 0 0 4 4 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC90655.1 - 2.4e-09 37.2 19.9 0.001 19.7 2.1 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger FOXP-CC PF16159.5 EMC90655.1 - 0.00058 20.4 5.9 1.8 9.2 0.2 3.5 1 1 2 3 3 3 2 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 EMC90655.1 - 0.0061 16.8 7.5 0.026 14.8 7.0 2.1 1 1 1 2 2 2 1 C2H2-type zinc ribbon zf-Di19 PF05605.12 EMC90655.1 - 0.029 14.7 6.4 0.11 12.8 1.4 2.6 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf_Hakai PF18408.1 EMC90655.1 - 0.07 12.9 0.5 0.07 12.9 0.5 2.9 3 0 0 3 3 3 0 C2H2 Hakai zinc finger domain GcpE PF04551.14 EMC90655.1 - 0.1 11.7 0.8 4.4 6.3 0.1 2.1 2 0 0 2 2 2 0 GcpE protein zf-C2H2_aberr PF17017.5 EMC90655.1 - 0.32 11.1 1.4 13 5.9 0.2 2.3 2 0 0 2 2 2 0 Aberrant zinc-finger Zn-C2H2_12 PF18112.1 EMC90655.1 - 0.48 10.9 2.5 1.6 9.3 0.4 2.7 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-TRAF PF02176.18 EMC90655.1 - 1.5 9.5 6.7 0.26 12.0 1.4 2.4 2 0 0 2 2 2 0 TRAF-type zinc finger zf-C2HC_2 PF13913.6 EMC90655.1 - 1.6 8.7 7.3 2.9 7.9 0.2 3.3 2 1 1 3 3 3 0 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.8 EMC90655.1 - 4.4 7.7 6.5 51 4.3 0.1 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding HSP20 PF00011.21 EMC90656.1 - 3.5e-09 36.7 0.1 4.1e-09 36.5 0.1 1.0 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ZFYVE21_C PF16696.5 EMC90656.1 - 0.08 12.8 0.0 0.087 12.7 0.0 1.1 1 0 0 1 1 1 0 Zinc finger FYVE domain-containing protein 21 C-terminus HECT PF00632.25 EMC90657.1 - 3.3e-65 220.6 0.0 5.5e-65 219.9 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) E3_UbLigase_EDD PF11547.8 EMC90657.1 - 1.2e-30 104.9 3.9 3.4e-30 103.5 3.9 1.8 1 0 0 1 1 1 1 E3 ubiquitin ligase EDD PABP PF00658.18 EMC90657.1 - 6.6e-20 71.1 0.0 1.4e-19 70.0 0.0 1.5 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain Ribonuc_red_sm PF00268.21 EMC90658.1 - 1.4e-123 411.8 0.9 1.7e-123 411.5 0.9 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Trypan_PARP PF05887.11 EMC90659.1 - 2.6e-09 37.1 17.5 4.3e-09 36.5 17.5 1.3 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) PA26 PF04636.13 EMC90659.1 - 0.00011 21.2 4.1 0.00018 20.6 4.1 1.2 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) Serinc PF03348.15 EMC90659.1 - 0.0013 17.7 0.1 0.0023 16.9 0.1 1.5 1 0 0 1 1 1 1 Serine incorporator (Serinc) SID-1_RNA_chan PF13965.6 EMC90659.1 - 0.0024 16.4 0.0 0.0026 16.3 0.0 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 DUF913 PF06025.12 EMC90659.1 - 0.0055 15.7 5.9 0.0092 15.0 5.9 1.3 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) SLC12 PF03522.15 EMC90659.1 - 0.0066 15.5 12.6 0.0096 15.0 12.6 1.2 1 0 0 1 1 1 1 Solute carrier family 12 DDHD PF02862.17 EMC90659.1 - 0.0067 16.6 4.2 0.015 15.5 3.5 2.1 2 0 0 2 2 2 1 DDHD domain SAPS PF04499.15 EMC90659.1 - 0.07 11.9 11.0 0.098 11.4 11.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SpoIIP PF07454.11 EMC90659.1 - 0.1 12.0 21.2 0.17 11.4 21.2 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) EOS1 PF12326.8 EMC90659.1 - 0.14 12.0 2.7 0.21 11.5 0.6 2.3 2 0 0 2 2 2 0 N-glycosylation protein BORG_CEP PF14957.6 EMC90659.1 - 0.19 12.9 10.1 0.55 11.4 10.1 1.8 1 0 0 1 1 1 0 Cdc42 effector Rrn6 PF10214.9 EMC90659.1 - 0.19 10.2 4.6 0.34 9.4 4.6 1.3 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Dynamin_N PF00350.23 EMC90659.1 - 0.36 10.9 5.6 0.46 10.5 4.6 1.8 2 0 0 2 2 2 0 Dynamin family MCM_bind PF09739.9 EMC90659.1 - 0.42 9.0 16.6 0.61 8.5 16.6 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DUF262 PF03235.14 EMC90659.1 - 0.56 10.3 8.9 0.81 9.8 8.9 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF262 Neur_chan_memb PF02932.16 EMC90659.1 - 0.84 9.6 8.9 0.11 12.6 4.9 1.6 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 EMC90659.1 - 1.1 8.0 21.8 2 7.1 21.8 1.3 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 EMC90659.1 - 1.2 7.9 27.8 1.8 7.3 27.8 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF1218 PF06749.12 EMC90659.1 - 1.2 9.7 4.6 10 6.7 0.0 2.9 3 0 0 3 3 2 0 Protein of unknown function (DUF1218) DUF5308 PF17233.2 EMC90659.1 - 2.4 8.4 5.7 2.2 8.5 3.8 2.0 2 0 0 2 2 1 0 Family of unknown function (DUF5308) RR_TM4-6 PF06459.12 EMC90659.1 - 2.7 7.7 36.0 4.6 7.0 36.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Sec62 PF03839.16 EMC90659.1 - 4.6 6.7 29.6 7.8 5.9 29.6 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Tim54 PF11711.8 EMC90659.1 - 5.3 5.7 26.6 9.7 4.9 26.6 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TRAP_alpha PF03896.16 EMC90659.1 - 6.4 5.9 13.8 13 4.9 13.8 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF2201_N PF13203.6 EMC90659.1 - 9.1 5.8 12.2 17 4.9 12.2 1.4 1 0 0 1 1 1 0 Putative metallopeptidase domain EF-hand_7 PF13499.6 EMC90660.1 - 3e-23 82.1 0.7 6.1e-12 45.8 0.0 3.1 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EMC90660.1 - 3.3e-20 70.1 4.8 2e-07 30.1 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EMC90660.1 - 1.4e-18 65.2 1.4 1.6e-06 27.6 0.1 4.7 4 1 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 EMC90660.1 - 2e-18 65.0 4.5 4.7e-06 25.9 0.1 4.8 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 EMC90660.1 - 1e-12 47.7 5.2 8.1e-07 28.8 0.2 4.1 3 2 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EMC90660.1 - 5.7e-05 23.4 0.1 0.086 13.2 0.0 2.6 2 2 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EMC90660.1 - 0.00078 19.4 0.3 0.15 12.1 0.0 2.6 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 EMC90660.1 - 0.035 14.3 0.1 8.5 6.7 0.0 2.4 2 1 0 2 2 2 0 Dockerin type I domain Fe_hyd_SSU PF02256.17 EMC90660.1 - 0.08 13.0 0.2 7 6.8 0.0 2.9 2 1 1 3 3 3 0 Iron hydrogenase small subunit CP2 PF04516.15 EMC90661.1 - 6e-85 284.2 3.7 7.7e-85 283.8 3.7 1.1 1 0 0 1 1 1 1 CP2 transcription factor DUF2089 PF09862.9 EMC90661.1 - 0.0033 17.4 0.1 0.0065 16.5 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2089) 4F5 PF04419.14 EMC90662.1 - 7.1e-11 42.8 17.3 9.3e-11 42.4 17.3 1.2 1 0 0 1 1 1 1 4F5 protein family zf-met PF12874.7 EMC90662.1 - 1.9e-05 24.9 0.2 3e-05 24.3 0.2 1.3 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMC90662.1 - 0.0027 18.0 0.3 0.0045 17.2 0.3 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_12 PF18658.1 EMC90662.1 - 0.0069 15.9 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger C2H2-type zf-C2H2_4 PF13894.6 EMC90662.1 - 0.011 16.5 1.3 0.016 16.0 1.3 1.3 1 0 0 1 1 1 0 C2H2-type zinc finger Ribosomal_L44 PF00935.19 EMC90662.1 - 0.013 15.9 4.0 0.016 15.7 4.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L44 DUF629 PF04780.12 EMC90662.1 - 0.02 13.4 1.4 0.021 13.4 0.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF629) zf-met2 PF12907.7 EMC90662.1 - 0.052 13.7 4.8 0.37 11.0 4.8 2.2 1 1 0 1 1 1 0 Zinc-binding PLATZ PF04640.14 EMC90662.1 - 0.054 14.1 1.7 0.072 13.7 1.7 1.2 1 0 0 1 1 1 0 PLATZ transcription factor 14-3-3 PF00244.20 EMC90663.1 - 6.3e-110 365.9 7.8 7.1e-110 365.8 7.8 1.0 1 0 0 1 1 1 1 14-3-3 protein FliM PF02154.15 EMC90663.1 - 0.076 12.9 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Flagellar motor switch protein FliM Peptidase_C98 PF15499.6 EMC90663.1 - 0.085 12.3 0.3 0.15 11.5 0.3 1.5 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase CSN7a_helixI PF18392.1 EMC90663.1 - 0.09 12.7 1.8 0.29 11.1 1.3 2.1 1 1 1 2 2 2 0 COP9 signalosome complex subunit 7a helix I domain DUF4518 PF15008.6 EMC90663.1 - 0.45 9.6 3.3 6.1 5.9 3.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4518) RRM_1 PF00076.22 EMC90664.1 - 6e-70 231.0 4.2 4.9e-25 87.1 0.2 4.3 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EMC90664.1 - 1.2e-32 111.9 0.2 5.7e-32 109.7 0.2 2.1 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 EMC90664.1 - 1.1e-07 31.5 0.2 0.08 12.5 0.1 3.6 1 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EMC90664.1 - 2.5e-05 24.3 0.6 1.9 8.6 0.0 3.6 3 0 0 3 3 3 2 Limkain b1 SET_assoc PF11767.8 EMC90664.1 - 5e-05 22.9 0.3 4.4 7.0 0.1 3.6 3 0 0 3 3 3 2 Histone lysine methyltransferase SET associated RRM_occluded PF16842.5 EMC90664.1 - 0.00019 21.3 0.0 0.29 11.0 0.0 3.4 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_3 PF08777.11 EMC90664.1 - 0.0003 20.8 8.7 0.13 12.3 1.0 3.5 4 0 0 4 4 3 2 RNA binding motif Nup35_RRM_2 PF14605.6 EMC90664.1 - 0.0016 18.4 0.2 6.9 6.8 0.0 3.5 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif ATP-grasp_2 PF08442.10 EMC90664.1 - 0.0018 17.9 0.2 1.4 8.4 0.0 2.7 3 0 0 3 3 3 2 ATP-grasp domain RRM_7 PF16367.5 EMC90664.1 - 0.0025 17.9 0.7 7.9 6.7 0.0 4.2 2 2 1 3 3 3 1 RNA recognition motif HATPase_c PF02518.26 EMC90664.1 - 0.0027 18.2 0.2 1.7 9.2 0.1 2.3 1 1 1 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase OB_RNB PF08206.11 EMC90664.1 - 0.014 15.1 3.0 4.1 7.2 0.1 3.4 3 0 0 3 3 3 0 Ribonuclease B OB domain YflT PF11181.8 EMC90664.1 - 0.034 14.7 1.2 1.7 9.2 0.2 2.8 3 0 0 3 3 3 0 Heat induced stress protein YflT Ank_4 PF13637.6 EMC90665.1 - 6.7e-22 77.6 0.6 1.1e-10 41.8 0.0 3.2 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMC90665.1 - 1e-15 58.1 0.1 4.6e-13 49.6 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMC90665.1 - 1.3e-12 47.7 0.1 1e-10 41.6 0.2 3.0 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EMC90665.1 - 1.7e-11 44.0 4.3 0.00015 22.1 0.2 4.3 3 1 1 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 EMC90665.1 - 3.1e-10 39.4 2.3 0.00069 19.9 0.1 4.6 5 0 0 5 5 5 3 Ankyrin repeat TPR_1 PF00515.28 EMC90666.1 - 5.7e-50 165.2 21.5 4.2e-06 26.3 0.2 9.4 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.17 EMC90666.1 - 1.3e-38 128.0 11.7 0.00088 19.2 0.0 9.7 8 1 1 9 9 9 9 Tetratricopeptide repeat TPR_8 PF13181.6 EMC90666.1 - 5e-20 70.0 19.0 0.004 17.3 0.0 9.2 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_9 PF13371.6 EMC90666.1 - 5.8e-17 61.6 2.1 1e-05 25.6 0.0 4.1 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EMC90666.1 - 1.5e-16 60.4 15.5 0.013 15.8 0.5 8.5 5 3 4 9 9 9 4 Tetratricopeptide repeat RPAP3_C PF13877.6 EMC90666.1 - 6.1e-16 58.7 0.0 1.9e-15 57.1 0.0 1.9 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 TPR_19 PF14559.6 EMC90666.1 - 1.2e-13 51.3 2.5 0.0054 17.2 0.0 5.5 3 2 1 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 EMC90666.1 - 2.2e-13 49.7 20.6 0.00014 21.5 0.1 7.3 7 1 1 8 8 8 4 TPR repeat TPR_16 PF13432.6 EMC90666.1 - 7.8e-11 42.4 0.1 0.0013 19.3 0.0 5.6 4 1 1 5 5 5 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMC90666.1 - 1.1e-09 38.2 14.6 0.025 14.7 0.1 6.3 5 3 3 8 8 7 4 Fis1 C-terminal tetratricopeptide repeat TPR_14 PF13428.6 EMC90666.1 - 1.9e-09 37.5 0.4 0.46 11.4 0.0 6.3 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 EMC90666.1 - 2.5e-08 33.4 12.5 1.5 9.1 0.0 8.5 10 0 0 10 10 8 1 Tetratricopeptide repeat TPR_17 PF13431.6 EMC90666.1 - 2.4e-06 27.5 15.6 0.1 13.0 0.0 6.7 6 0 0 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC90666.1 - 9.9e-05 22.5 12.0 1.1 9.5 3.1 4.4 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EMC90666.1 - 0.00011 22.6 12.4 0.67 10.7 0.2 7.0 8 0 0 8 8 7 1 Tetratricopeptide repeat DUF4919 PF16266.5 EMC90666.1 - 0.00093 19.2 3.8 0.082 12.9 0.0 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4919) MIT PF04212.18 EMC90666.1 - 0.0024 17.9 16.3 5.7 7.1 0.1 6.2 5 2 3 8 8 8 1 MIT (microtubule interacting and transport) domain TPR_10 PF13374.6 EMC90666.1 - 0.0064 16.3 11.3 0.036 13.9 0.2 6.0 7 0 0 7 7 6 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EMC90666.1 - 0.14 12.6 1.1 2.8 8.4 0.1 2.9 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation TPR_20 PF14561.6 EMC90666.1 - 0.15 12.4 0.1 0.15 12.4 0.1 3.3 4 0 0 4 4 3 0 Tetratricopeptide repeat DNA_RNApol_7kD PF03604.13 EMC90667.1 - 1.7e-17 62.7 8.8 2.6e-17 62.2 8.8 1.3 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit A2L_zn_ribbon PF08792.10 EMC90667.1 - 0.00051 19.7 1.0 0.00092 18.9 1.0 1.4 1 0 0 1 1 1 1 A2L zinc ribbon domain Cytochrome_C7 PF14522.6 EMC90667.1 - 0.0042 17.0 0.4 0.0053 16.7 0.4 1.2 1 0 0 1 1 1 1 Cytochrome c7 and related cytochrome c DZR PF12773.7 EMC90667.1 - 0.0054 16.7 1.8 0.0069 16.4 1.8 1.3 1 0 0 1 1 1 1 Double zinc ribbon MCM_OB PF17207.3 EMC90667.1 - 0.0061 16.4 1.7 0.0063 16.4 1.7 1.0 1 0 0 1 1 1 1 MCM OB domain HypA PF01155.19 EMC90667.1 - 0.014 15.4 1.7 0.017 15.2 1.7 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_13 PF09855.9 EMC90667.1 - 0.11 12.7 0.6 0.11 12.7 0.6 1.7 1 1 0 1 1 1 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) zf-Sec23_Sec24 PF04810.15 EMC90667.1 - 1.1 9.3 6.3 15 5.8 0.1 2.5 2 1 0 2 2 2 0 Sec23/Sec24 zinc finger IBR PF01485.21 EMC90668.1 - 1.2e-06 28.7 4.9 4.1e-06 26.9 4.9 2.0 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain F-box-like PF12937.7 EMC90668.1 - 0.12 12.3 0.8 0.66 9.9 0.1 2.2 2 0 0 2 2 2 0 F-box-like Phage_holin_8 PF16931.5 EMC90668.1 - 0.21 11.6 0.0 0.38 10.8 0.0 1.3 1 0 0 1 1 1 0 Putative phage holin zf-RING_4 PF14570.6 EMC90668.1 - 2.4 8.0 6.8 17 5.3 2.7 2.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain RGS PF00615.19 EMC90669.1 - 2.5e-08 34.2 0.1 3.3e-08 33.8 0.1 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain HHH_3 PF12836.7 EMC90669.1 - 0.0049 17.1 0.1 0.039 14.2 0.0 2.2 2 1 0 2 2 2 1 Helix-hairpin-helix motif tify PF06200.14 EMC90669.1 - 0.11 11.9 1.0 6.3 6.2 0.2 2.4 2 0 0 2 2 2 0 tify domain COX6C PF02937.15 EMC90670.1 - 3.8e-36 123.1 1.2 4.2e-36 122.9 1.2 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIc Fe_hyd_SSU PF02256.17 EMC90671.1 - 0.045 13.8 0.1 0.057 13.5 0.1 1.2 1 0 0 1 1 1 0 Iron hydrogenase small subunit Pkinase PF00069.25 EMC90672.1 - 8.7e-72 241.6 0.0 1.5e-71 240.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC90672.1 - 6.9e-53 179.6 1.4 1.3e-52 178.7 0.0 2.1 3 0 0 3 3 3 1 Protein tyrosine kinase Mst1_SARAH PF11629.8 EMC90672.1 - 2.4e-25 88.3 5.1 2.4e-25 88.3 5.1 2.2 2 0 0 2 2 2 1 C terminal SARAH domain of Mst1 Pkinase_fungal PF17667.1 EMC90672.1 - 3e-06 26.3 2.0 3.2e-06 26.2 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 EMC90672.1 - 0.0094 14.9 0.2 2.8 6.8 0.0 2.3 1 1 1 2 2 2 2 Haspin like kinase domain Abi_2 PF07751.11 EMC90672.1 - 0.051 13.8 0.0 0.051 13.8 0.0 2.1 2 1 1 3 3 3 0 Abi-like protein Selenoprotein_S PF06936.11 EMC90672.1 - 0.071 12.9 2.2 0.16 11.7 2.2 1.5 1 0 0 1 1 1 0 Selenoprotein S (SelS) Fib_succ_major PF09603.10 EMC90672.1 - 0.11 13.1 0.6 0.23 12.1 0.3 1.7 1 1 0 1 1 1 0 Fibrobacter succinogenes major domain (Fib_succ_major) Ion_trans PF00520.31 EMC90673.1 - 4.1e-41 140.8 5.2 6.9e-41 140.1 5.2 1.4 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 EMC90673.1 - 2.8e-31 107.7 0.1 4.2e-30 104.0 0.1 2.5 2 0 0 2 2 2 1 BTB/POZ domain Ion_trans_2 PF07885.16 EMC90673.1 - 4e-13 49.1 3.5 4e-13 49.1 3.5 2.1 2 0 0 2 2 2 1 Ion channel BTB_3 PF16017.5 EMC90673.1 - 0.078 13.1 0.1 0.3 11.2 0.0 2.0 1 1 1 2 2 2 0 BTB/POZ domain Mg_trans_NIPA PF05653.14 EMC90674.1 - 2e-91 306.2 25.0 2.3e-91 306.0 25.0 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EMC90674.1 - 0.0052 17.0 6.7 0.0052 17.0 6.7 3.4 2 2 1 3 3 3 1 EamA-like transporter family Ribonuc_L-PSP PF01042.21 EMC90676.1 - 2.1e-42 143.9 0.1 2.4e-42 143.7 0.1 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Corona_6B_7B PF03262.13 EMC90676.1 - 0.014 14.8 0.0 0.018 14.5 0.0 1.1 1 0 0 1 1 1 0 Coronavirus 6B/7B protein DUF5506 PF17611.2 EMC90676.1 - 0.16 11.9 0.0 0.21 11.5 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5506) Ribosomal_L7Ae PF01248.26 EMC90677.1 - 3.5e-26 90.8 0.1 4e-26 90.6 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Hydrolase_6 PF13344.6 EMC90677.1 - 0.033 14.3 0.0 0.042 14.0 0.0 1.1 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Mtp PF03821.16 EMC90678.1 - 9.1e-11 41.8 5.6 1.9e-06 27.7 0.8 2.1 1 1 0 2 2 2 2 Golgi 4-transmembrane spanning transporter DUF4728 PF15860.5 EMC90678.1 - 0.0039 17.8 3.3 0.0039 17.8 3.3 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4728) ABC2_membrane_2 PF12679.7 EMC90678.1 - 0.83 8.9 10.7 0.032 13.5 4.1 1.7 2 0 0 2 2 2 0 ABC-2 family transporter protein Tetraspanin PF00335.20 EMC90678.1 - 1.2 8.8 11.9 0.027 14.2 2.4 2.0 1 1 1 2 2 2 0 Tetraspanin family LYRIC PF15686.5 EMC90679.1 - 6.6e-95 319.1 27.7 6.6e-95 319.1 27.7 2.7 1 1 1 2 2 2 1 Lysine-rich CEACAM1 co-isolated protein family PA PF02225.22 EMC90681.1 - 0.00087 19.3 0.0 0.0016 18.5 0.0 1.4 1 0 0 1 1 1 1 PA domain 4HB_MCP_1 PF12729.7 EMC90681.1 - 0.18 11.4 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction Syndecan PF01034.20 EMC90682.1 - 5e-30 103.2 0.0 9.2e-30 102.4 0.0 1.5 1 0 0 1 1 1 1 Syndecan domain DUF2721 PF11026.8 EMC90682.1 - 0.036 14.0 0.0 0.054 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) DUF2207 PF09972.9 EMC90682.1 - 0.039 12.7 0.0 0.042 12.6 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Peptidase_M50 PF02163.22 EMC90682.1 - 0.095 12.0 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Peptidase family M50 Glycophorin_A PF01102.18 EMC90682.1 - 0.1 12.8 4.6 0.58 10.4 4.6 2.0 1 1 0 1 1 1 0 Glycophorin A DUF2407_C PF13373.6 EMC90682.1 - 0.12 12.6 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 DUF2407 C-terminal domain DUF4407 PF14362.6 EMC90682.1 - 0.16 11.3 0.0 0.19 11.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ATG22 PF11700.8 EMC90682.1 - 0.24 10.0 0.0 0.28 9.8 0.0 1.1 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like TGF_beta_GS PF08515.12 EMC90682.1 - 0.25 10.9 0.9 0.65 9.5 0.9 1.7 1 0 0 1 1 1 0 Transforming growth factor beta type I GS-motif MtrF PF09472.10 EMC90682.1 - 0.39 10.1 2.9 0.67 9.4 2.9 1.3 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Glypican PF01153.19 EMC90682.1 - 0.49 9.2 1.9 0.59 8.9 1.9 1.1 1 0 0 1 1 1 0 Glypican PSS PF03034.15 EMC90683.1 - 3.6e-105 351.6 23.8 3.6e-105 351.6 23.8 1.8 2 0 0 2 2 2 1 Phosphatidyl serine synthase Peptidase_C1 PF00112.23 EMC90683.1 - 0.084 13.0 0.2 0.15 12.1 0.2 1.3 1 0 0 1 1 1 0 Papain family cysteine protease Cyt_b-c1_8 PF10890.8 EMC90683.1 - 0.11 12.9 0.1 0.39 11.2 0.1 1.9 1 0 0 1 1 1 0 Cytochrome b-c1 complex subunit 8 CD225 PF04505.12 EMC90683.1 - 9.2 6.5 7.9 8 6.7 0.2 3.3 3 0 0 3 3 3 0 Interferon-induced transmembrane protein mTERF PF02536.14 EMC90684.1 - 4.8e-29 101.3 1.2 6.2e-29 100.9 1.2 1.1 1 0 0 1 1 1 1 mTERF UCR_14kD PF02271.16 EMC90685.1 - 3.2e-40 136.1 1.0 3.7e-40 135.9 1.0 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit RMP PF14996.6 EMC90686.1 - 1.6e-53 181.1 6.5 1.8e-53 180.9 6.5 1.0 1 0 0 1 1 1 1 Retinal Maintenance FYVE PF01363.21 EMC90687.1 - 6.6e-19 67.8 7.4 1.5e-18 66.7 7.4 1.6 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 EMC90687.1 - 5.5e-11 42.9 0.5 2e-10 41.1 0.1 2.1 2 1 1 3 3 3 1 PH domain FYVE_2 PF02318.16 EMC90687.1 - 0.0012 19.1 5.4 0.0022 18.2 5.4 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger PH_13 PF16652.5 EMC90687.1 - 0.0038 17.0 0.7 0.11 12.3 0.7 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH_16 PF17838.1 EMC90687.1 - 0.0062 16.4 0.1 0.027 14.3 0.1 1.9 1 1 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 EMC90687.1 - 0.025 14.5 0.1 0.052 13.5 0.1 1.5 1 0 0 1 1 1 0 PH domain DUF1835 PF08874.10 EMC90687.1 - 0.053 13.7 0.1 0.13 12.5 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1835) zf-HYPF PF07503.12 EMC90687.1 - 3.9 7.3 7.8 14 5.6 7.8 2.0 1 1 0 1 1 1 0 HypF finger zf-B_box PF00643.24 EMC90687.1 - 6 7.1 9.3 5.8 7.2 6.3 2.4 2 1 0 2 2 2 0 B-box zinc finger SQS_PSY PF00494.19 EMC90688.1 - 7.9e-53 179.6 0.4 9.4e-53 179.4 0.4 1.0 1 0 0 1 1 1 1 Squalene/phytoene synthase DOR PF14839.6 EMC90689.1 - 2.7e-81 273.2 9.9 5.4e-81 272.2 9.9 1.5 1 1 0 1 1 1 1 DOR family Cyclin_N PF00134.23 EMC90690.1 - 1.2e-39 134.9 1.5 2.5e-39 133.9 1.5 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EMC90690.1 - 4.8e-19 68.6 0.1 1e-18 67.5 0.1 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain TPR_2 PF07719.17 EMC90691.1 - 0.00052 19.9 5.8 0.25 11.5 0.3 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMC90691.1 - 0.0072 16.0 0.5 0.9 9.3 0.1 3.1 2 0 0 2 2 2 1 TPR repeat TPR_7 PF13176.6 EMC90691.1 - 0.028 14.5 0.7 3 8.1 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EMC90691.1 - 0.22 11.8 6.9 7.6 7.0 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EMC90691.1 - 0.27 11.1 10.2 2.6 8.0 0.7 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMC90691.1 - 0.28 11.4 4.3 0.34 11.1 0.1 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Cadherin PF00028.17 EMC90692.1 - 4.3e-213 690.6 23.4 9.3e-22 77.3 0.0 15.3 15 0 0 15 15 15 14 Cadherin domain Cadherin_C PF01049.17 EMC90692.1 - 8e-42 143.0 0.2 2e-41 141.7 0.2 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic region Laminin_G_2 PF02210.24 EMC90692.1 - 8.3e-32 110.4 2.7 1.8e-17 64.1 0.0 3.1 3 0 0 3 3 2 2 Laminin G domain Laminin_G_1 PF00054.23 EMC90692.1 - 2.9e-25 89.0 0.1 2.8e-11 43.7 0.0 2.8 2 0 0 2 2 2 2 Laminin G domain EGF PF00008.27 EMC90692.1 - 3.2e-14 52.9 50.3 1.4e-06 28.4 8.0 4.6 4 0 0 4 4 4 4 EGF-like domain Cadherin_pro PF08758.11 EMC90692.1 - 2.2e-12 46.9 0.0 7.6e-05 22.8 0.0 7.6 9 0 0 9 9 9 1 Cadherin prodomain like hEGF PF12661.7 EMC90692.1 - 9.4e-10 38.8 36.4 0.0014 19.2 4.2 4.9 4 0 0 4 4 4 4 Human growth factor-like EGF Cadherin_2 PF08266.12 EMC90692.1 - 6.5e-09 35.5 0.0 1.6 8.6 0.0 7.4 8 0 0 8 8 8 2 Cadherin-like RET_CLD1 PF17756.1 EMC90692.1 - 1.7e-07 31.6 0.8 1.6 9.0 0.0 7.3 9 0 0 9 9 7 1 RET Cadherin like domain 1 Y_Y_Y PF07495.13 EMC90692.1 - 4.9e-06 26.4 3.7 0.24 11.4 0.1 5.0 4 0 0 4 4 4 2 Y_Y_Y domain Laminin_G_3 PF13385.6 EMC90692.1 - 0.00062 19.9 0.0 0.056 13.6 0.0 3.7 4 0 0 4 4 3 1 Concanavalin A-like lectin/glucanases superfamily DUF4975 PF16346.5 EMC90692.1 - 0.014 15.4 1.0 0.063 13.4 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4975) EGF_2 PF07974.13 EMC90692.1 - 0.02 15.3 59.0 0.0096 16.3 10.0 4.2 4 0 0 4 4 3 0 EGF-like domain PKD PF00801.20 EMC90692.1 - 0.52 10.2 7.9 45 4.0 0.1 6.4 6 0 0 6 6 6 0 PKD domain He_PIG PF05345.12 EMC90692.1 - 3.9 7.7 15.4 0.44 10.8 0.4 6.0 6 0 0 6 6 5 0 Putative Ig domain RRM_1 PF00076.22 EMC90693.1 - 1.5e-15 56.8 0.0 0.0004 20.2 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 EMC90693.1 - 0.08 13.2 0.0 28 4.9 0.0 3.1 3 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter zf-C3HC4_2 PF13923.6 EMC90694.1 - 9.2e-10 38.2 8.1 9.2e-10 38.2 8.1 2.4 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC90694.1 - 1.2e-07 31.5 7.5 1.2e-07 31.5 7.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-TRAF PF02176.18 EMC90694.1 - 2.7e-07 31.2 4.1 2.7e-07 31.2 4.1 3.4 1 1 2 3 3 3 1 TRAF-type zinc finger zf-RING_UBOX PF13445.6 EMC90694.1 - 1.5e-06 28.1 8.5 1.5e-06 28.1 8.5 2.0 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EMC90694.1 - 1.8e-06 28.0 6.1 1.8e-06 28.0 6.1 2.6 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EMC90694.1 - 1.8e-06 28.1 7.9 1.8e-06 28.1 7.9 3.0 2 1 0 2 2 1 1 Ring finger domain Sina PF03145.16 EMC90694.1 - 5.5e-06 26.5 3.6 5.5e-06 26.5 3.6 2.8 1 1 2 3 3 3 2 Seven in absentia protein family zf-C3HC4_3 PF13920.6 EMC90694.1 - 6.3e-06 26.0 3.4 6.3e-06 26.0 3.4 2.9 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EMC90694.1 - 0.00031 20.6 1.8 0.00031 20.6 1.8 2.1 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-TRAF_2 PF15965.5 EMC90694.1 - 0.00096 19.6 7.2 0.011 16.1 0.4 3.7 2 1 2 4 4 4 2 TRAF-like zinc-finger Prok-RING_4 PF14447.6 EMC90694.1 - 0.0011 18.7 7.2 0.0011 18.7 7.2 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 DUF1640 PF07798.11 EMC90694.1 - 0.0049 16.9 8.4 0.0084 16.2 8.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) zf-RING_5 PF14634.6 EMC90694.1 - 0.0076 16.2 5.7 0.0076 16.2 5.7 2.5 2 1 0 2 2 1 1 zinc-RING finger domain zf-RING_10 PF16685.5 EMC90694.1 - 0.013 15.6 7.4 0.045 13.9 7.4 2.0 1 1 0 1 1 1 0 zinc RING finger of MSL2 zf-rbx1 PF12678.7 EMC90694.1 - 0.018 15.3 10.7 0.018 15.3 10.7 4.2 3 2 1 4 4 4 0 RING-H2 zinc finger domain GCN5L1 PF06320.13 EMC90694.1 - 0.064 13.4 5.6 0.1 12.8 5.6 1.2 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) Utp12 PF04003.12 EMC90694.1 - 0.11 12.8 1.8 12 6.2 0.5 2.5 2 1 0 2 2 2 0 Dip2/Utp12 Family Fzo_mitofusin PF04799.13 EMC90694.1 - 0.34 10.4 6.6 0.64 9.6 6.6 1.5 1 0 0 1 1 1 0 fzo-like conserved region Spc7 PF08317.11 EMC90694.1 - 0.88 8.4 12.1 1.2 8.0 12.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1664 PF07889.12 EMC90694.1 - 1.1 9.4 5.1 1.8 8.6 5.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) IFT20 PF14931.6 EMC90694.1 - 1.6 8.9 11.8 1.4 9.1 8.8 2.2 1 1 1 2 2 2 0 Intraflagellar transport complex B, subunit 20 MRPL52 PF18699.1 EMC90694.1 - 8.2 6.7 8.8 8.5 6.6 7.6 1.6 1 1 0 1 1 1 0 Mitoribosomal protein mL52 Ras PF00071.22 EMC90695.1 - 2.4e-31 108.5 0.0 5.7e-31 107.3 0.0 1.6 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EMC90695.1 - 4.5e-09 36.6 0.0 1e-08 35.4 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EMC90695.1 - 8.1e-06 25.8 0.0 0.021 14.8 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EMC90695.1 - 7.1e-05 22.9 0.0 0.00015 21.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EMC90695.1 - 0.00016 21.2 0.1 0.00085 18.9 0.1 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.27 EMC90695.1 - 0.0013 19.2 0.0 0.0024 18.4 0.0 1.8 1 1 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 EMC90695.1 - 0.0015 18.8 0.1 1.1 9.5 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 EMC90695.1 - 0.021 15.2 0.2 0.065 13.6 0.0 1.9 1 1 1 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 EMC90695.1 - 0.022 14.5 0.1 0.094 12.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EMC90695.1 - 0.064 13.4 0.0 0.13 12.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain DUF2369 PF10179.9 EMC90695.1 - 0.091 13.2 0.0 0.24 11.8 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2369) pXO2-34 PF17362.2 EMC90695.1 - 0.096 12.6 0.5 35 4.4 0.0 3.2 3 0 0 3 3 3 0 Family of unknown function AAA_5 PF07728.14 EMC90695.1 - 0.13 12.3 0.0 0.33 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Cadherin PF00028.17 EMC90696.1 - 1.3e-63 211.4 16.2 3.4e-14 53.1 0.1 7.2 7 0 0 7 7 7 7 Cadherin domain RET_CLD1 PF17756.1 EMC90696.1 - 8e-08 32.6 0.0 0.38 11.0 0.0 4.7 4 1 1 5 5 5 2 RET Cadherin like domain 1 Cadherin_3 PF16184.5 EMC90696.1 - 6.1e-07 29.4 8.1 0.19 11.7 0.1 6.1 7 0 0 7 7 7 3 Cadherin-like Cadherin_4 PF17803.1 EMC90696.1 - 2.5e-05 24.8 11.7 1.2 9.8 0.1 5.5 5 0 0 5 5 5 3 Bacterial cadherin-like domain Invasin_D3 PF09134.10 EMC90696.1 - 0.00019 21.6 3.6 0.14 12.5 0.0 4.5 4 0 0 4 4 4 1 Invasin, domain 3 Big_9 PF17963.1 EMC90696.1 - 0.55 11.0 18.4 3.2 8.6 0.3 5.7 5 0 0 5 5 5 0 Bacterial Ig domain Big_1 PF02369.16 EMC90696.1 - 1.1 9.4 11.8 33 4.6 1.1 5.6 4 1 0 4 4 4 0 Bacterial Ig-like domain (group 1) PP2C PF00481.21 EMC90697.1 - 1.1e-37 130.1 0.0 8.9e-37 127.1 0.0 2.0 1 1 1 2 2 2 1 Protein phosphatase 2C Meckelin PF09773.9 EMC90698.1 - 0 1166.0 13.1 0 1166.0 13.1 1.5 2 0 0 2 2 2 1 Meckelin (Transmembrane protein 67) NCD3G PF07562.14 EMC90698.1 - 3.8 7.5 16.0 0.23 11.4 4.2 2.8 2 0 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR RRM_1 PF00076.22 EMC90699.1 - 5.3e-34 115.9 0.1 5.2e-06 26.2 0.0 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAM92 PF06730.11 EMC90700.1 - 5.9e-101 336.5 10.2 6.7e-101 336.4 10.2 1.0 1 0 0 1 1 1 1 FAM92 protein Vps5 PF09325.10 EMC90700.1 - 0.0071 15.9 7.2 0.25 10.8 4.3 2.9 2 1 1 3 3 3 2 Vps5 C terminal like HTH_42 PF06224.12 EMC90700.1 - 0.02 14.4 0.3 0.029 13.9 0.3 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain CemA PF03040.14 EMC90700.1 - 0.11 12.5 1.2 0.16 11.9 1.2 1.3 1 0 0 1 1 1 0 CemA family SAM_Exu PF18609.1 EMC90700.1 - 0.31 11.2 2.9 1.1 9.4 0.6 2.7 3 1 0 3 3 3 0 Exuperantia SAM-like domain TRIQK PF15168.6 EMC90701.1 - 3.2e-38 129.5 0.7 3.6e-38 129.3 0.7 1.0 1 0 0 1 1 1 1 Triple QxxK/R motif-containing protein family Wbp11 PF09429.10 EMC90701.1 - 0.039 14.3 1.6 0.055 13.9 1.6 1.2 1 0 0 1 1 1 0 WW domain binding protein 11 DDE_1 PF03184.19 EMC90702.1 - 3.1e-11 43.2 0.0 4.7e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease NHR2 PF08788.11 EMC90703.1 - 5e-40 135.1 8.8 1.6e-39 133.5 8.8 1.9 1 0 0 1 1 1 1 NHR2 domain like TAFH PF07531.14 EMC90703.1 - 2.4e-34 117.3 1.4 4.6e-34 116.4 1.4 1.5 1 0 0 1 1 1 1 NHR1 homology to TAF zf-MYND PF01753.18 EMC90703.1 - 3e-07 30.4 18.2 3e-07 30.4 18.2 2.1 2 0 0 2 2 2 1 MYND finger Efg1 PF10153.9 EMC90703.1 - 0.029 14.7 2.0 0.085 13.2 2.0 1.7 1 0 0 1 1 1 0 rRNA-processing protein Efg1 DUF3731 PF12531.8 EMC90703.1 - 0.11 12.3 3.7 0.04 13.7 1.0 1.6 2 0 0 2 2 2 0 DNA-K related protein DUF4434 PF14488.6 EMC90703.1 - 0.15 12.1 0.2 0.15 12.1 0.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4434) MAJIN PF15077.6 EMC90703.1 - 0.32 10.8 3.5 0.68 9.7 3.5 1.5 1 0 0 1 1 1 0 Membrane-anchored junction protein vATP-synt_E PF01991.18 EMC90703.1 - 1.2 8.5 12.4 1.9 7.9 12.4 1.3 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit ARGLU PF15346.6 EMC90703.1 - 2.4 8.0 14.0 0.21 11.4 7.0 2.2 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 DivIVA PF05103.13 EMC90703.1 - 3.5 7.7 9.1 8.2 6.5 9.1 1.6 1 0 0 1 1 1 0 DivIVA protein Tmemb_55A PF09788.9 EMC90704.1 - 1.5e-97 325.6 15.7 1.6e-97 325.4 15.7 1.0 1 0 0 1 1 1 1 Transmembrane protein 55A zf-BED PF02892.15 EMC90704.1 - 0.036 14.1 10.4 0.4 10.7 0.0 3.9 3 1 1 4 4 4 0 BED zinc finger zinc_ribbon_12 PF11331.8 EMC90704.1 - 0.087 12.6 0.7 0.087 12.6 0.7 3.7 3 1 1 4 4 4 0 Probable zinc-ribbon domain zinc_ribbon_4 PF13717.6 EMC90704.1 - 0.48 10.4 0.0 0.48 10.4 0.0 4.9 5 1 1 6 6 6 0 zinc-ribbon domain eIF_4EBP PF05456.11 EMC90705.1 - 0.013 15.4 0.0 0.014 15.3 0.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) EF-hand_6 PF13405.6 EMC90706.1 - 1.6e-24 83.7 8.9 8.9e-08 31.5 0.6 5.5 5 0 0 5 5 5 5 EF-hand domain EF-hand_1 PF00036.32 EMC90706.1 - 5e-24 82.0 9.8 1.4e-07 30.6 1.0 5.3 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 EMC90706.1 - 6.3e-22 77.8 6.7 3e-11 43.6 2.2 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EMC90706.1 - 7.2e-15 53.7 8.8 0.00035 19.9 0.0 4.6 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 EMC90706.1 - 1.3e-09 37.7 2.7 2.3e-06 27.3 0.2 2.8 2 0 0 2 2 2 2 EF-hand domain pair T3SS_HrpK1 PF16937.5 EMC90706.1 - 0.00073 19.3 0.2 0.099 12.3 0.0 2.4 2 1 1 3 3 3 1 Type III secretion system translocator protein, HrpF SPARC_Ca_bdg PF10591.9 EMC90706.1 - 0.0031 17.8 3.9 1.2 9.5 0.1 3.3 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region LXG PF04740.12 EMC90706.1 - 0.012 15.4 3.6 1.3 8.7 0.3 3.0 3 0 0 3 3 3 0 LXG domain of WXG superfamily Caleosin PF05042.13 EMC90706.1 - 0.024 14.6 1.9 2.8 7.8 0.1 3.0 1 1 2 3 3 3 0 Caleosin related protein Styelin PF17562.2 EMC90706.1 - 0.035 14.5 0.1 0.57 10.6 0.0 2.5 2 0 0 2 2 2 0 Styelin ArgoMid PF16487.5 EMC90706.1 - 0.1 12.9 0.5 3.9 7.8 0.0 3.0 3 1 0 3 3 3 0 Mid domain of argonaute EF-hand_9 PF14658.6 EMC90706.1 - 0.13 12.6 0.3 27 5.2 0.0 3.2 3 1 0 3 3 3 0 EF-hand domain EF-hand_10 PF14788.6 EMC90706.1 - 0.16 11.9 10.3 2.6 8.0 0.4 4.3 3 1 1 4 4 4 0 EF hand Dockerin_1 PF00404.18 EMC90706.1 - 0.26 11.5 3.0 1.8 8.8 0.1 3.1 2 2 2 4 4 4 0 Dockerin type I domain adh_short_C2 PF13561.6 EMC90707.1 - 3.4e-48 164.2 1.4 4.9e-48 163.7 1.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMC90707.1 - 2.7e-34 118.4 2.9 3.9e-34 117.8 2.9 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMC90707.1 - 8.5e-08 32.3 0.2 1.4e-07 31.6 0.2 1.4 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 EMC90707.1 - 0.0046 16.0 0.1 0.0065 15.5 0.1 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EMC90707.1 - 0.0055 16.2 0.1 0.0085 15.6 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMC90707.1 - 0.012 15.0 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase AA_permease_2 PF13520.6 EMC90708.1 - 1.6e-63 215.0 36.5 2e-63 214.7 36.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMC90708.1 - 3.3e-29 101.8 28.2 3.3e-29 101.8 28.2 1.4 1 1 0 1 1 1 1 Amino acid permease Copine PF07002.16 EMC90709.1 - 7.4e-92 306.7 0.0 1.1e-91 306.1 0.0 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 EMC90709.1 - 2.8e-29 101.4 0.3 3.8e-14 52.8 0.0 2.4 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 EMC90709.1 - 1.4e-05 25.3 0.0 6.6e-05 23.1 0.0 2.0 2 0 0 2 2 2 1 vWA found in TerF C terminus DUF3211 PF11485.8 EMC90709.1 - 0.027 14.7 0.1 0.057 13.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3211) TPR_17 PF13431.6 EMC90710.1 - 7.6e-08 32.2 1.9 0.59 10.6 0.6 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 EMC90710.1 - 6.1e-07 29.0 12.3 0.85 9.5 0.0 4.9 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_19 PF14559.6 EMC90710.1 - 1.1e-06 29.1 1.0 0.072 13.6 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMC90710.1 - 1.4e-05 24.8 16.0 1.5 9.1 0.0 6.0 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 EMC90710.1 - 1.7e-05 25.2 3.8 9.2 7.4 0.1 5.0 3 2 1 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMC90710.1 - 0.0019 18.8 3.6 2.7 8.7 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMC90710.1 - 0.036 13.8 1.1 7.5 6.3 0.0 3.9 4 1 0 4 4 4 0 TPR repeat ANAPC3 PF12895.7 EMC90710.1 - 0.061 13.6 6.6 0.9 9.8 0.2 3.4 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 PPTA PF01239.22 EMC90710.1 - 0.077 12.8 0.1 0.36 10.6 0.1 2.3 1 0 0 1 1 1 0 Protein prenyltransferase alpha subunit repeat AbLIM_anchor PF16182.5 EMC90710.1 - 0.17 11.6 0.1 0.33 10.7 0.0 1.4 2 0 0 2 2 2 0 Putative adherens-junction anchoring region of AbLIM HECT PF00632.25 EMC90711.1 - 1.7e-97 326.7 0.5 2.4e-97 326.1 0.5 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 EMC90711.1 - 2.9e-50 168.0 31.0 2.1e-13 50.1 1.5 4.6 4 0 0 4 4 4 4 WW domain C2 PF00168.30 EMC90711.1 - 2e-12 47.3 0.2 4.7e-12 46.1 0.2 1.6 1 0 0 1 1 1 1 C2 domain Carb_anhydrase PF00194.21 EMC90712.1 - 1.1e-94 316.7 0.0 1.3e-94 316.5 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Carb_anhydrase PF00194.21 EMC90713.1 - 4e-80 269.0 0.0 7.9e-80 268.0 0.0 1.4 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Carb_anhydrase PF00194.21 EMC90714.1 - 1.2e-83 280.5 0.0 1.4e-83 280.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Carb_anhydrase PF00194.21 EMC90715.1 - 5e-35 121.3 0.1 6.1e-35 121.0 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Carb_anhydrase PF00194.21 EMC90716.1 - 1.5e-91 306.4 0.0 1.7e-91 306.3 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase E2F_CC-MB PF16421.5 EMC90717.1 - 2.1e-29 101.7 0.3 3e-29 101.2 0.3 1.2 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.20 EMC90717.1 - 2.3e-14 53.2 0.3 4.9e-14 52.1 0.3 1.6 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain LRR_4 PF12799.7 EMC90718.1 - 2.1e-14 53.4 23.8 1.8e-09 37.7 1.4 5.1 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC90718.1 - 5e-12 45.7 1.7 8.9e-10 38.3 0.8 3.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 EMC90718.1 - 1e-10 41.2 25.2 3.8e-08 33.0 7.3 3.7 2 1 2 4 4 4 3 Leucine rich repeat LRR_6 PF13516.6 EMC90718.1 - 0.0089 16.0 25.7 0.15 12.2 0.5 5.7 3 1 2 5 5 5 3 Leucine Rich repeat LRR_1 PF00560.33 EMC90718.1 - 6.5 7.7 18.1 1.1 10.1 0.3 4.8 4 1 0 4 4 4 0 Leucine Rich Repeat AA_permease_2 PF13520.6 EMC90719.1 - 7.9e-58 196.3 40.9 9.8e-58 196.0 40.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMC90719.1 - 1.8e-21 76.3 35.1 2.5e-21 75.8 35.1 1.2 1 0 0 1 1 1 1 Amino acid permease TRIQK PF15168.6 EMC90719.1 - 0.083 12.8 0.1 0.33 10.9 0.1 2.1 1 0 0 1 1 1 0 Triple QxxK/R motif-containing protein family IES5 PF17335.2 EMC90720.1 - 0.012 15.8 1.3 0.019 15.3 1.3 1.2 1 0 0 1 1 1 0 Ino80 complex subunit 5 Alpha-2-MRAP_C PF06401.11 EMC90720.1 - 0.013 15.5 2.9 0.018 15.0 2.9 1.1 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, C-terminal domain SKA2 PF16740.5 EMC90720.1 - 0.016 15.0 2.5 0.022 14.5 2.5 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 Golgin_A5 PF09787.9 EMC90720.1 - 0.017 14.6 5.0 0.021 14.3 5.0 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 SR-25 PF10500.9 EMC90720.1 - 0.027 14.1 5.2 0.034 13.8 5.2 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein XhlA PF10779.9 EMC90720.1 - 0.08 13.2 6.0 0.13 12.4 6.0 1.4 1 0 0 1 1 1 0 Haemolysin XhlA RP-C_C PF11800.8 EMC90720.1 - 0.097 12.8 2.6 0.13 12.4 2.6 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF4349 PF14257.6 EMC90720.1 - 0.18 11.3 1.3 0.28 10.6 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) PA26 PF04636.13 EMC90720.1 - 0.27 10.1 1.9 0.33 9.8 1.9 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF4407 PF14362.6 EMC90720.1 - 0.33 10.3 3.0 0.42 9.9 3.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PIEZO PF15917.5 EMC90720.1 - 0.5 9.8 4.7 0.7 9.3 4.7 1.1 1 0 0 1 1 1 0 Piezo DUF4611 PF15387.6 EMC90720.1 - 6.4 7.1 14.1 0.067 13.4 5.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) RRM_1 PF00076.22 EMC90721.1 - 7.8e-11 41.6 0.0 1.1e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EMC90721.1 - 0.021 14.8 0.3 0.04 13.9 0.2 1.5 1 1 1 2 2 2 0 Nup53/35/40-type RNA recognition motif PX PF00787.24 EMC90722.1 - 2.7e-19 69.2 0.9 3.8e-19 68.7 0.0 1.7 2 0 0 2 2 2 1 PX domain DUF641 PF04859.12 EMC90722.1 - 0.00082 19.7 0.8 0.0055 17.0 0.5 2.1 2 0 0 2 2 2 1 Plant protein of unknown function (DUF641) Lip_prot_lig_C PF10437.9 EMC90722.1 - 0.071 13.1 0.1 4.9 7.2 0.1 2.5 2 0 0 2 2 2 0 Bacterial lipoate protein ligase C-terminus Snf7 PF03357.21 EMC90724.1 - 1.2e-42 145.5 10.7 1.7e-42 145.0 10.7 1.2 1 0 0 1 1 1 1 Snf7 SYF2 PF08231.12 EMC90724.1 - 0.002 18.5 3.8 0.0024 18.3 3.1 1.4 1 1 0 1 1 1 1 SYF2 splicing factor DDE_Tnp_ISAZ013 PF07592.11 EMC90724.1 - 0.031 13.3 1.1 0.04 12.9 1.1 1.1 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain DUF3984 PF13136.6 EMC90724.1 - 0.064 12.7 1.5 0.075 12.4 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) ABC_tran_CTD PF16326.5 EMC90724.1 - 0.23 11.7 12.4 2.9 8.2 0.4 2.4 1 1 1 2 2 2 0 ABC transporter C-terminal domain GreA_GreB_N PF03449.15 EMC90724.1 - 1.5 9.1 7.8 0.7 10.1 2.9 2.7 2 1 1 3 3 3 0 Transcription elongation factor, N-terminal zf-AN1 PF01428.16 EMC90725.1 - 4.1e-20 71.7 28.4 2.4e-11 43.6 14.8 2.8 3 0 0 3 3 3 2 AN1-like Zinc finger EndoU_bacteria PF14436.6 EMC90725.1 - 0.043 14.2 0.0 0.067 13.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial EndoU nuclease Lipocalin PF00061.23 EMC90726.1 - 1.5e-26 93.3 3.1 1.7e-26 93.1 3.1 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 EMC90726.1 - 0.001 19.0 2.4 0.0013 18.6 2.4 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin PF00061.23 EMC90727.1 - 6.5e-26 91.3 1.0 7.2e-26 91.1 1.0 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 EMC90727.1 - 6e-06 26.2 1.6 9.4e-06 25.6 1.6 1.3 1 1 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family SCVP PF17619.2 EMC90727.1 - 0.029 15.2 0.3 0.22 12.4 0.4 2.2 2 1 0 2 2 2 0 Secreted clade V proteins ChitinaseA_N PF08329.10 EMC90727.1 - 0.12 12.0 0.2 0.17 11.5 0.2 1.4 1 1 0 1 1 1 0 Chitinase A, N-terminal domain Lipocalin PF00061.23 EMC90728.1 - 1.9e-07 31.4 0.3 1.9e-07 31.4 0.3 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family PhnA PF03831.14 EMC90728.1 - 0.064 13.1 0.1 0.081 12.8 0.1 1.2 1 0 0 1 1 1 0 PhnA domain MRP_L53 PF10780.9 EMC90729.1 - 6.5e-17 61.5 0.0 1.1e-16 60.7 0.0 1.4 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 Ank_2 PF12796.7 EMC90730.1 - 7e-26 90.6 0.4 4.1e-10 40.1 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMC90730.1 - 1.5e-22 79.6 2.0 5.7e-09 36.3 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EMC90730.1 - 4.8e-20 71.0 1.1 0.0025 18.2 0.0 5.6 5 0 0 5 5 5 5 Ankyrin repeat Ank_3 PF13606.6 EMC90730.1 - 1.7e-19 67.8 0.4 0.0011 19.3 0.0 5.6 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 EMC90730.1 - 3.6e-15 55.8 1.3 1.4e-05 25.3 0.1 4.4 2 1 2 4 4 4 4 Ankyrin repeats (many copies) 7tm_1 PF00001.21 EMC90731.1 - 1.5e-29 103.2 19.9 1.9e-29 102.8 19.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2975 PF11188.8 EMC90731.1 - 6.4 6.7 11.2 0.37 10.7 3.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2975) Sushi PF00084.20 EMC90732.1 - 5.8e-21 74.9 3.7 1.4e-09 38.4 0.4 2.6 2 1 0 2 2 2 2 Sushi repeat (SCR repeat) Dus PF01207.17 EMC90733.1 - 1.2e-56 192.1 0.0 1.6e-56 191.7 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) zf-CCCH_4 PF18044.1 EMC90733.1 - 2.1e-07 30.6 12.4 1.7e-06 27.7 3.0 3.7 3 0 0 3 3 3 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EMC90733.1 - 0.001 19.1 10.6 0.012 15.7 1.2 2.9 2 0 0 2 2 2 2 Zinc finger domain PEP_mutase PF13714.6 EMC90733.1 - 0.015 14.7 0.0 0.029 13.8 0.0 1.4 1 0 0 1 1 1 0 Phosphoenolpyruvate phosphomutase FMN_dh PF01070.18 EMC90733.1 - 0.015 14.3 0.0 0.023 13.7 0.0 1.2 1 0 0 1 1 1 0 FMN-dependent dehydrogenase zf-CCCH PF00642.24 EMC90733.1 - 0.051 13.5 15.5 0.32 11.0 2.1 3.5 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) VIT PF08487.10 EMC90734.1 - 1.6e-22 79.8 0.0 2.1e-22 79.4 0.0 1.2 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VIT_2 PF13757.6 EMC90734.1 - 3.3e-07 30.1 0.1 7.5e-07 29.0 0.1 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain Calcipressin PF04847.12 EMC90736.1 - 2e-57 194.0 0.3 2.3e-57 193.8 0.3 1.0 1 0 0 1 1 1 1 Calcipressin Limkain-b1 PF11608.8 EMC90736.1 - 0.14 12.2 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Limkain b1 RRM_occluded PF16842.5 EMC90736.1 - 0.16 11.9 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif 7tm_1 PF00001.21 EMC90738.1 - 3.4e-30 105.3 34.8 5.1e-30 104.7 34.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) VWD PF00094.25 EMC90739.1 - 7.8e-16 58.7 0.1 8.5e-16 58.6 0.1 1.0 1 0 0 1 1 1 1 von Willebrand factor type D domain BAAT_C PF08840.11 EMC90740.1 - 1e-71 241.3 0.0 1.2e-71 241.0 0.0 1.0 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.13 EMC90740.1 - 0.011 15.4 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 EMC90740.1 - 0.012 15.0 0.0 0.035 13.6 0.0 1.8 1 1 0 1 1 1 0 Prolyl oligopeptidase family DLH PF01738.18 EMC90740.1 - 0.062 12.9 0.3 0.3 10.6 0.0 2.1 2 1 0 2 2 2 0 Dienelactone hydrolase family PAC4 PF16093.5 EMC90742.1 - 0.0091 16.2 0.1 0.015 15.4 0.1 1.4 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 Trypsin PF00089.26 EMC90744.1 - 2.5e-24 86.3 0.0 2.7e-24 86.2 0.0 1.0 1 0 0 1 1 1 1 Trypsin COMM_domain PF07258.14 EMC90745.1 - 0.00058 19.9 0.3 0.00068 19.7 0.3 1.3 1 0 0 1 1 1 1 COMM domain BLOC1_2 PF10046.9 EMC90745.1 - 0.017 15.4 0.3 0.021 15.1 0.3 1.1 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 p450 PF00067.22 EMC90746.1 - 3e-26 92.2 0.1 3.3e-26 92.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 PDEase_I PF00233.19 EMC90748.1 - 2e-33 116.1 4.8 2.3e-33 115.9 4.8 1.1 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase zf-H2C2_2 PF13465.6 EMC90749.1 - 2e-05 24.8 8.1 0.0014 19.0 1.3 2.1 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.26 EMC90749.1 - 0.0012 19.2 6.2 0.0013 19.1 0.9 2.2 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC90749.1 - 0.0083 16.9 0.8 0.0083 16.9 0.8 2.1 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC90749.1 - 0.029 14.4 2.2 0.059 13.4 2.2 1.6 1 1 0 1 1 1 0 C2H2-type zinc finger zinc_ribbon_12 PF11331.8 EMC90749.1 - 0.07 12.9 0.2 0.087 12.6 0.2 1.2 1 0 0 1 1 1 0 Probable zinc-ribbon domain MAM PF00629.23 EMC90750.1 - 1.7e-34 119.1 0.0 1.9e-34 118.9 0.0 1.0 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu DUF2381 PF09544.10 EMC90750.1 - 0.15 11.5 0.1 0.18 11.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2381) TLV_coat PF00429.19 EMC90751.1 - 4.1e-06 25.8 0.2 5e-06 25.5 0.2 1.0 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) RL10P_insert PF17777.1 EMC90752.1 - 2.7e-28 97.7 0.0 4e-28 97.2 0.0 1.2 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P TraF PF13728.6 EMC90752.1 - 0.13 12.1 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein LRR_8 PF13855.6 EMC90753.1 - 3.1e-21 74.9 16.2 8.2e-17 60.7 9.3 2.2 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EMC90753.1 - 2.9e-08 33.9 13.1 2.3e-05 24.7 5.9 3.0 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EMC90753.1 - 2.1e-07 30.6 1.3 0.0015 18.1 0.0 2.0 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 EMC90753.1 - 5.5e-07 29.2 13.6 0.0037 17.6 0.7 4.1 4 0 0 4 4 4 3 Leucine Rich Repeat LRR_5 PF13306.6 EMC90753.1 - 0.00082 19.3 0.0 0.001 19.1 0.0 1.1 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_2 PF07723.13 EMC90753.1 - 0.0027 18.3 0.2 0.26 12.0 0.1 2.5 2 0 0 2 2 2 1 Leucine Rich Repeat LRR_6 PF13516.6 EMC90753.1 - 0.56 10.4 10.7 18 5.7 0.3 4.2 4 0 0 4 4 4 0 Leucine Rich repeat Arf PF00025.21 EMC90754.1 - 3.1e-06 26.8 0.0 3.1e-06 26.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family RRM_1 PF00076.22 EMC90754.1 - 0.1 12.4 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) p450 PF00067.22 EMC90755.1 - 3.1e-32 112.0 0.1 3.3e-32 111.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 LRR_8 PF13855.6 EMC90756.1 - 6.1e-63 208.5 35.0 1.9e-15 56.3 4.0 5.0 2 2 4 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 EMC90756.1 - 1.6e-31 107.8 30.7 1.1e-07 32.0 0.7 5.8 2 1 6 8 8 8 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EMC90756.1 - 3.5e-18 65.8 0.0 3.4e-13 49.7 0.0 2.3 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EMC90756.1 - 1.5e-13 50.6 1.9 1.3e-07 31.2 0.7 2.2 1 1 0 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 EMC90756.1 - 5e-09 35.5 23.5 0.11 13.2 0.0 8.8 8 1 0 8 8 8 4 Leucine Rich Repeat LRRNT PF01462.18 EMC90756.1 - 4.6e-06 26.1 2.7 4.6e-06 26.1 2.7 2.7 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 EMC90756.1 - 1.9e-05 24.3 18.9 13 6.2 0.1 8.1 8 0 0 8 8 8 2 Leucine Rich repeat VWD PF00094.25 EMC90757.1 - 4.6e-15 56.2 0.1 5e-15 56.1 0.1 1.0 1 0 0 1 1 1 1 von Willebrand factor type D domain IRF-2BP1_2 PF11261.8 EMC90757.1 - 0.068 12.7 0.5 0.65 9.6 0.4 2.0 1 1 1 2 2 2 0 Interferon regulatory factor 2-binding protein zinc finger UDPGT PF00201.18 EMC90758.1 - 3e-61 207.7 0.0 3.4e-61 207.6 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Transferrin PF00405.17 EMC90760.1 - 8.3e-22 77.8 0.0 1e-21 77.5 0.0 1.1 1 0 0 1 1 1 1 Transferrin Trypsin_2 PF13365.6 EMC90761.1 - 1.7e-07 32.3 1.9 2.1e-07 32.0 1.9 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S46 PF10459.9 EMC90761.1 - 0.3 9.7 0.1 0.36 9.4 0.1 1.0 1 0 0 1 1 1 0 Peptidase S46 DUF3421 PF11901.8 EMC90764.1 - 3.4e-15 56.0 2.5 4.7e-13 49.1 0.2 2.8 1 1 2 3 3 3 2 Protein of unknown function (DUF3421) HU-CCDC81_euk_2 PF18289.1 EMC90765.1 - 8.2e-26 90.0 0.0 1.2e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 2 p450 PF00067.22 EMC90766.1 - 4.9e-28 98.1 0.8 5.2e-28 98.0 0.8 1.0 1 0 0 1 1 1 1 Cytochrome P450 TMEM234 PF10639.9 EMC90767.1 - 2.3e-16 59.9 0.1 2.4e-16 59.8 0.1 1.0 1 0 0 1 1 1 1 Putative transmembrane family 234 TLV_coat PF00429.19 EMC90768.1 - 1.7e-07 30.4 0.7 1.9e-07 30.1 0.7 1.0 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) MIP-T3_C PF17749.1 EMC90768.1 - 0.038 14.0 0.2 2.2 8.2 0.0 2.1 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region WXG100 PF06013.12 EMC90768.1 - 0.18 12.1 2.6 0.72 10.1 1.1 2.0 2 0 0 2 2 2 0 Proteins of 100 residues with WXG Epimerase PF01370.21 EMC90769.1 - 1.5e-25 90.0 0.0 1.8e-25 89.8 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EMC90769.1 - 1.3e-06 27.7 0.0 1.8e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EMC90769.1 - 8.7e-06 25.1 0.9 0.00043 19.5 0.0 2.0 1 1 1 2 2 2 2 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EMC90769.1 - 0.0046 16.4 2.0 0.012 15.0 0.0 2.0 1 1 1 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EMC90769.1 - 0.1 11.6 1.3 2.5 7.0 1.3 2.0 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family cNMP_binding PF00027.29 EMC90770.1 - 1.9e-18 66.3 0.0 2.3e-18 66.0 0.0 1.0 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain VWD PF00094.25 EMC90771.1 - 1.7e-15 57.6 0.3 1.8e-15 57.5 0.3 1.0 1 0 0 1 1 1 1 von Willebrand factor type D domain zf-H2C2_2 PF13465.6 EMC90772.1 - 3.9e-10 39.7 13.4 5.9e-10 39.1 1.7 2.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 EMC90772.1 - 2.5e-09 37.1 9.6 4.5e-06 26.8 2.1 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC90772.1 - 2e-08 34.4 8.5 5.3e-05 23.7 1.6 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EMC90772.1 - 3.5e-07 29.8 4.2 0.00011 21.9 0.1 2.1 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-C2HC_2 PF13913.6 EMC90772.1 - 2.1e-06 27.5 7.7 0.0081 16.0 0.8 2.3 2 0 0 2 2 2 2 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.8 EMC90772.1 - 5.5e-05 23.3 0.0 0.016 15.5 0.0 2.1 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 EMC90772.1 - 0.021 15.3 3.2 1.6 9.2 1.3 2.1 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zinc_ribbon_9 PF14369.6 EMC90772.1 - 0.028 14.7 1.5 1.1 9.5 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon zf-Di19 PF05605.12 EMC90772.1 - 0.048 13.9 2.2 0.091 13.1 2.2 1.6 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding HNH PF01844.23 EMC90772.1 - 0.055 13.7 3.8 0.14 12.3 0.4 2.0 2 0 0 2 2 2 0 HNH endonuclease Rad50_zn_hook PF04423.14 EMC90772.1 - 0.31 10.9 2.9 0.37 10.7 0.2 2.2 1 1 1 2 2 2 0 Rad50 zinc hook motif zf_C2H2_ZHX PF18387.1 EMC90772.1 - 0.39 10.4 2.8 4.7 6.9 1.1 2.0 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-AN1 PF01428.16 EMC90772.1 - 0.69 10.1 8.1 3.2 8.0 1.9 2.2 2 0 0 2 2 2 0 AN1-like Zinc finger zf-C2H2_6 PF13912.6 EMC90772.1 - 3.2 7.9 10.8 1.6 8.9 3.6 2.4 2 1 0 2 2 2 0 C2H2-type zinc finger MMtag PF10159.9 EMC90773.1 - 2.1e-33 114.4 0.4 2.5e-33 114.2 0.4 1.1 1 0 0 1 1 1 1 Multiple myeloma tumor-associated Laminin_EGF PF00053.24 EMC90774.1 - 4.9e-09 36.2 20.3 4e-05 23.7 5.2 2.3 1 1 1 2 2 2 2 Laminin EGF domain hEGF PF12661.7 EMC90774.1 - 1e-05 25.9 6.7 1e-05 25.9 6.7 4.2 2 1 1 3 3 3 2 Human growth factor-like EGF EGF_2 PF07974.13 EMC90774.1 - 0.00012 22.3 29.3 0.0045 17.3 9.1 3.4 3 1 0 3 3 3 3 EGF-like domain EGF PF00008.27 EMC90774.1 - 0.0021 18.3 12.3 0.0021 18.3 12.3 3.2 3 0 0 3 3 3 2 EGF-like domain EB PF01683.18 EMC90774.1 - 0.0053 17.0 19.0 0.08 13.3 14.4 2.1 1 1 1 2 2 2 2 EB module cEGF PF12662.7 EMC90774.1 - 0.09 12.7 19.3 0.89 9.5 0.6 4.1 3 1 1 4 4 4 0 Complement Clr-like EGF-like I-EGF_1 PF18372.1 EMC90774.1 - 0.34 11.0 17.7 1 9.5 0.3 4.1 4 0 0 4 4 4 0 Integrin beta epidermal growth factor like domain 1 DSL PF01414.19 EMC90774.1 - 0.71 10.2 23.8 1.2 9.5 14.2 2.1 1 1 0 2 2 2 0 Delta serrate ligand FXa_inhibition PF14670.6 EMC90774.1 - 4.3 7.7 24.5 20 5.6 0.2 3.2 1 1 2 3 3 3 0 Coagulation Factor Xa inhibitory site Tme5_EGF_like PF09064.10 EMC90774.1 - 9.6 6.2 23.9 3.5 7.6 7.3 3.2 2 1 1 3 3 3 0 Thrombomodulin like fifth domain, EGF-like YL1 PF05764.13 EMC90775.1 - 3.8e-24 86.1 5.5 4.4e-24 86.0 5.5 1.0 1 0 0 1 1 1 1 YL1 nuclear protein TFIIE_beta PF02186.15 EMC90775.1 - 0.079 13.3 0.6 0.13 12.6 0.6 1.3 1 0 0 1 1 1 0 TFIIE beta subunit core domain SspO PF08175.12 EMC90775.1 - 4.7 7.8 8.4 12 6.5 0.5 2.5 2 1 0 2 2 2 0 Small acid-soluble spore protein O family Cullin_Nedd8 PF10557.9 EMC90776.1 - 5.5e-17 61.6 0.1 7.5e-17 61.1 0.1 1.2 1 0 0 1 1 1 1 Cullin protein neddylation domain MHC_I PF00129.18 EMC90777.1 - 5.9e-29 100.9 0.6 7.8e-29 100.5 0.6 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.15 EMC90777.1 - 3.4e-14 53.0 0.0 9.2e-14 51.6 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.6 EMC90777.1 - 2.7e-07 31.1 0.0 1.1e-06 29.1 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 EMC90777.1 - 7.4e-05 23.0 0.0 0.00021 21.6 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 EMC90777.1 - 0.002 18.3 0.0 0.012 15.7 0.0 2.2 2 1 0 2 2 2 1 Immunoglobulin domain MHC_I_3 PF16497.5 EMC90777.1 - 0.0024 17.4 0.0 0.003 17.1 0.0 1.1 1 0 0 1 1 1 1 MHC-I family domain I-set PF07679.16 EMC90777.1 - 0.025 14.6 0.0 0.12 12.4 0.0 2.0 2 0 0 2 2 2 0 Immunoglobulin I-set domain zf-H2C2_2 PF13465.6 EMC90778.1 - 4.6e-18 64.7 5.8 4e-09 36.5 0.5 2.7 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 EMC90778.1 - 2.1e-10 40.5 20.1 8.1e-06 26.0 0.7 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC90778.1 - 2.5e-08 34.1 17.6 0.00029 21.4 0.5 3.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf_UBZ PF18439.1 EMC90778.1 - 0.006 16.1 0.9 0.21 11.2 0.1 2.1 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger zf-C2H2_11 PF16622.5 EMC90778.1 - 0.011 15.5 0.1 0.011 15.5 0.1 2.6 2 1 0 2 2 2 0 zinc-finger C2H2-type DZR PF12773.7 EMC90778.1 - 0.013 15.5 0.4 0.018 15.1 0.4 1.2 1 0 0 1 1 1 0 Double zinc ribbon zf-MYST PF17772.1 EMC90778.1 - 0.025 14.2 5.2 0.29 10.8 0.6 2.1 2 0 0 2 2 2 0 MYST family zinc finger domain Zn-ribbon_8 PF09723.10 EMC90778.1 - 0.034 14.2 1.3 2.5 8.3 0.1 2.2 2 0 0 2 2 2 0 Zinc ribbon domain zf-C2H2_6 PF13912.6 EMC90778.1 - 0.051 13.6 0.8 0.051 13.6 0.8 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger GATA PF00320.27 EMC90778.1 - 0.058 13.0 0.7 0.2 11.3 0.0 2.0 2 0 0 2 2 2 0 GATA zinc finger zf-H2C2_5 PF13909.6 EMC90778.1 - 0.066 13.0 0.5 0.066 13.0 0.5 4.6 4 1 0 4 4 3 0 C2H2-type zinc-finger domain zf-C2H2_7 PF15269.6 EMC90778.1 - 0.27 11.3 7.5 2.6 8.2 0.8 2.1 1 1 1 2 2 2 0 Zinc-finger zf-C2H2_jaz PF12171.8 EMC90778.1 - 0.62 10.4 0.2 0.62 10.4 0.2 2.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 EMC90778.1 - 1.8 9.1 10.4 0.88 10.1 1.7 2.5 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Rubredoxin_2 PF18073.1 EMC90778.1 - 2.8 7.7 7.8 1.1 9.0 1.1 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain SNF2_N PF00176.23 EMC90779.1 - 0.0098 14.7 0.0 0.01 14.6 0.0 1.0 1 0 0 1 1 1 1 SNF2 family N-terminal domain Neurexophilin PF06312.12 EMC90780.1 - 2.7e-102 340.7 1.8 3e-102 340.5 1.8 1.0 1 0 0 1 1 1 1 Neurexophilin Filamin PF00630.19 EMC90780.1 - 0.0067 17.2 0.5 0.58 11.0 0.0 2.2 1 1 1 2 2 2 2 Filamin/ABP280 repeat HSP70 PF00012.20 EMC90781.1 - 1.1e-28 99.9 0.4 1.2e-28 99.7 0.4 1.0 1 0 0 1 1 1 1 Hsp70 protein Lipoprotein_21 PF14041.6 EMC90781.1 - 0.083 13.0 0.1 0.11 12.7 0.1 1.2 1 0 0 1 1 1 0 LppP/LprE lipoprotein 7tm_4 PF13853.6 EMC90782.1 - 2.7e-22 79.8 7.9 3.7e-22 79.4 7.9 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 EMC90782.1 - 4e-16 59.1 5.4 6.2e-16 58.5 5.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 EMC90782.1 - 2.9e-05 23.6 7.9 2.9e-05 23.6 7.9 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx PNTB_4TM PF12769.7 EMC90782.1 - 0.014 15.8 4.7 0.014 15.8 4.7 1.6 2 0 0 2 2 2 0 4TM region of pyridine nucleotide transhydrogenase, mitoch Pkinase PF00069.25 EMC90784.1 - 4.4e-06 26.3 0.0 5.1e-06 26.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMC90784.1 - 0.029 13.6 0.0 0.033 13.5 0.0 1.0 1 0 0 1 1 1 0 Protein tyrosine kinase Hormone_recep PF00104.30 EMC90785.1 - 2.3e-08 33.9 0.0 2.3e-08 33.9 0.0 1.0 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C3HC4_3 PF13920.6 EMC90786.1 - 9.8e-09 34.9 11.2 1.3e-08 34.6 11.2 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMC90786.1 - 5.9e-07 29.3 14.0 8e-07 28.8 14.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMC90786.1 - 2.7e-06 27.1 13.7 4.4e-06 26.4 13.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMC90786.1 - 2e-05 24.4 15.1 0.0003 20.7 15.8 2.0 1 1 1 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMC90786.1 - 0.00016 21.5 10.9 0.00023 21.0 10.9 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EMC90786.1 - 0.00026 21.3 14.3 0.00049 20.4 14.3 1.5 1 1 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EMC90786.1 - 0.00057 19.9 10.0 0.00096 19.1 10.0 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 EMC90786.1 - 0.0079 16.5 11.8 0.0079 16.5 11.8 1.9 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EMC90786.1 - 0.019 15.1 11.3 0.039 14.1 11.5 1.5 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 EMC90786.1 - 0.058 13.5 5.6 0.08 13.0 5.6 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 EMC90786.1 - 0.072 13.0 3.5 0.1 12.5 3.5 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Rtf2 PF04641.12 EMC90786.1 - 0.21 10.9 3.3 0.21 10.9 3.3 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger zf-RING_4 PF14570.6 EMC90786.1 - 5.8 6.8 15.4 30 4.5 15.5 1.9 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain UDPGT PF00201.18 EMC90787.1 - 2.3e-30 105.9 0.1 2.5e-30 105.8 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase zf-C2H2 PF00096.26 EMC90788.1 - 5.1e-07 29.8 5.8 2.3e-06 27.7 2.5 2.1 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC90788.1 - 1.2e-06 28.7 1.9 0.14 12.6 0.0 3.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC90788.1 - 0.00043 20.9 1.5 0.00043 20.9 1.5 2.0 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMC90788.1 - 0.0012 18.8 0.5 0.0025 17.8 0.5 1.6 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC90788.1 - 0.0075 16.5 0.1 0.011 16.0 0.1 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding Anti-TRAP PF15777.5 EMC90788.1 - 0.5 10.4 3.0 1.3 9.1 0.3 2.1 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein V-set PF07686.17 EMC90789.1 - 2e-14 53.6 0.0 2.3e-14 53.5 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 EMC90789.1 - 2e-05 25.1 0.2 6.4e-05 23.5 0.2 1.8 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 EMC90789.1 - 0.00022 21.3 0.0 0.0005 20.2 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 EMC90789.1 - 0.0005 20.1 0.0 0.00067 19.7 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 EMC90789.1 - 0.0048 17.2 0.1 0.0098 16.2 0.1 1.5 1 1 0 1 1 1 1 Immunoglobulin domain Ig_6 PF18452.1 EMC90789.1 - 0.18 11.4 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain KOW PF00467.29 EMC90790.1 - 0.00024 21.0 2.3 0.00035 20.4 2.3 1.3 1 0 0 1 1 1 1 KOW motif ribosomal_L24 PF17136.4 EMC90790.1 - 0.03 14.7 0.0 0.049 14.0 0.0 1.5 1 1 0 1 1 1 0 Ribosomal proteins 50S L24/mitochondrial 39S L24 Ras PF00071.22 EMC90791.1 - 2.2e-13 50.1 0.0 2.4e-13 50.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMC90791.1 - 1.3e-07 31.9 0.0 1.4e-07 31.8 0.0 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Homeodomain PF00046.29 EMC90792.1 - 1.3e-17 63.4 0.5 1.4e-17 63.3 0.5 1.0 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMC90792.1 - 0.0056 16.6 0.1 0.0081 16.0 0.1 1.3 1 0 0 1 1 1 1 Homeobox KN domain RNA_pol_Rpb1_5 PF04998.17 EMC90793.1 - 7.7e-05 22.2 0.0 7.8e-05 22.2 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_6 PF04992.14 EMC90793.1 - 0.014 15.2 0.0 0.02 14.8 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 6 Keratin PF02422.16 EMC90794.1 - 1.7e-26 91.7 12.3 1.9e-26 91.6 12.3 1.0 1 0 0 1 1 1 1 Keratin Fer4_3 PF12798.7 EMC90794.1 - 1.4 10.0 6.6 13 7.0 0.2 2.2 2 0 0 2 2 2 0 4Fe-4S binding domain zf-C2H2 PF00096.26 EMC90795.1 - 1.6e-14 53.5 4.8 1.8e-06 28.1 1.1 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC90795.1 - 1.1e-11 44.6 12.9 9.9e-07 28.9 0.4 3.0 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC90795.1 - 7.7e-09 35.6 5.3 0.00034 21.2 0.2 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EMC90795.1 - 1e-05 25.2 1.0 0.024 14.4 0.0 2.1 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 EMC90795.1 - 0.00037 20.7 0.7 0.32 11.3 0.2 2.2 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding DUF2256 PF10013.9 EMC90795.1 - 0.005 16.9 1.1 0.49 10.5 0.1 2.1 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2256) zf-trcl PF13451.6 EMC90795.1 - 0.0085 16.0 1.2 0.09 12.7 0.1 2.1 2 0 0 2 2 2 1 Probable zinc-ribbon domain zf-met PF12874.7 EMC90795.1 - 0.009 16.4 4.7 0.38 11.2 0.7 2.4 2 1 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 EMC90795.1 - 0.013 15.4 0.0 0.013 15.4 0.0 2.7 2 1 0 2 2 2 0 zinc-finger of a C2HC-type Zn-ribbon_8 PF09723.10 EMC90795.1 - 0.015 15.4 1.9 0.14 12.3 2.1 2.0 1 1 1 2 2 2 0 Zinc ribbon domain zf-C2H2_8 PF15909.5 EMC90795.1 - 0.027 14.7 0.1 0.028 14.7 0.1 1.1 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 EMC90795.1 - 0.032 14.2 1.2 0.032 14.2 1.2 3.0 2 1 0 2 2 2 0 C2H2-type zinc finger LIM PF00412.22 EMC90795.1 - 0.036 14.3 0.5 0.073 13.3 0.5 1.5 1 1 0 1 1 1 0 LIM domain DNA_RNApol_7kD PF03604.13 EMC90795.1 - 0.043 13.5 0.6 3.7 7.3 0.0 2.2 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit zf-LYAR PF08790.11 EMC90795.1 - 0.065 13.1 1.5 1.6 8.7 0.1 2.3 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf_UBZ PF18439.1 EMC90795.1 - 0.08 12.6 0.3 7.6 6.2 0.1 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Zn_ribbon_recom PF13408.6 EMC90795.1 - 0.16 12.5 4.8 2.7 8.6 1.0 2.1 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain zf-BED PF02892.15 EMC90795.1 - 0.17 11.9 4.7 1.8 8.6 4.7 2.2 1 1 0 1 1 1 0 BED zinc finger IBR PF01485.21 EMC90795.1 - 0.19 12.0 3.9 0.49 10.6 3.9 1.6 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain zf-C2HE PF16278.5 EMC90795.1 - 2 8.9 6.3 0.86 10.1 2.0 2.1 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Dynein_light PF01221.18 EMC90796.1 - 3.2e-31 107.5 1.0 3.5e-31 107.3 1.0 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Trypsin PF00089.26 EMC90797.1 - 2.7e-17 63.3 3.1 2.9e-17 63.2 3.1 1.0 1 0 0 1 1 1 1 Trypsin Trypsin PF00089.26 EMC90798.1 - 2.7e-15 56.8 0.8 2.9e-15 56.7 0.8 1.0 1 0 0 1 1 1 1 Trypsin DUF1242 PF06842.12 EMC90799.1 - 9.1e-12 44.6 2.4 1.1e-11 44.3 2.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) Keratin PF02422.16 EMC90800.1 - 2.3e-38 129.8 7.5 2.5e-38 129.6 7.5 1.0 1 0 0 1 1 1 1 Keratin EF-hand_4 PF12763.7 EMC90801.1 - 1.4e-12 47.5 0.0 1.6e-12 47.2 0.0 1.0 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EMC90801.1 - 0.00045 19.6 0.0 0.00058 19.2 0.0 1.1 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 EMC90801.1 - 0.0065 15.9 0.0 0.0091 15.5 0.0 1.2 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EMC90801.1 - 0.023 14.6 0.0 0.032 14.1 0.0 1.2 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.6 EMC90801.1 - 0.034 14.6 0.0 0.035 14.6 0.0 1.1 1 0 0 1 1 1 0 EF-hand domain pair zf-H2C2_2 PF13465.6 EMC90802.1 - 7.6e-23 79.9 11.5 2.5e-08 34.0 0.7 3.0 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.26 EMC90802.1 - 2.1e-12 46.8 10.1 4.6e-07 29.9 1.4 3.9 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC90802.1 - 2e-07 31.2 9.9 6.7e-05 23.4 1.9 3.2 4 0 0 4 4 3 2 C2H2-type zinc finger zf_UBZ PF18439.1 EMC90802.1 - 8.4e-05 22.1 7.8 0.048 13.3 0.1 3.1 3 0 0 3 3 3 2 Ubiquitin-Binding Zinc Finger zf-AN1 PF01428.16 EMC90802.1 - 0.00016 21.7 5.2 0.72 10.1 0.2 3.2 3 0 0 3 3 3 2 AN1-like Zinc finger zf-trcl PF13451.6 EMC90802.1 - 0.00025 20.9 5.8 0.082 12.8 0.1 3.1 3 0 0 3 3 3 1 Probable zinc-ribbon domain zf-C2H2_jaz PF12171.8 EMC90802.1 - 0.00029 21.0 3.7 0.012 15.9 0.2 2.5 3 0 0 3 3 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC90802.1 - 0.00033 20.9 6.4 0.25 11.8 1.3 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-LYAR PF08790.11 EMC90802.1 - 0.00044 20.1 9.7 0.062 13.2 0.2 3.2 3 0 0 3 3 3 2 LYAR-type C2HC zinc finger zf-C2HC_2 PF13913.6 EMC90802.1 - 0.0031 17.4 4.2 0.28 11.1 0.3 2.6 2 0 0 2 2 2 2 zinc-finger of a C2HC-type Zn-ribbon_8 PF09723.10 EMC90802.1 - 0.007 16.5 1.6 0.007 16.5 1.6 2.5 1 1 1 2 2 2 1 Zinc ribbon domain zf-C2HE PF16278.5 EMC90802.1 - 0.0081 16.6 10.2 0.82 10.2 0.5 3.1 1 1 2 3 3 3 2 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_8 PF15909.5 EMC90802.1 - 0.0099 16.2 3.4 0.013 15.8 2.0 1.7 1 1 0 1 1 1 1 C2H2-type zinc ribbon LIM PF00412.22 EMC90802.1 - 0.017 15.3 8.2 0.58 10.4 0.4 2.9 1 1 2 3 3 3 0 LIM domain C1_1 PF00130.22 EMC90802.1 - 0.022 14.6 6.5 0.19 11.6 1.7 2.5 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc_ribbon_15 PF17032.5 EMC90802.1 - 0.023 15.5 2.6 0.027 15.2 0.4 1.8 1 1 1 2 2 2 0 zinc-ribbon family CpXC PF14353.6 EMC90802.1 - 0.024 14.7 4.9 1.9 8.5 0.1 2.5 1 1 1 3 3 3 0 CpXC protein HypA PF01155.19 EMC90802.1 - 0.028 14.4 2.4 0.26 11.3 0.8 2.0 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_7 PF02591.15 EMC90802.1 - 0.033 14.4 4.8 1 9.6 0.1 3.0 3 1 0 3 3 3 0 C4-type zinc ribbon domain zf_C2H2_ZHX PF18387.1 EMC90802.1 - 0.04 13.5 11.6 0.21 11.3 0.6 2.9 1 1 3 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain ATPase-cat_bd PF12156.8 EMC90802.1 - 0.043 14.5 6.6 0.055 14.2 3.3 2.0 2 0 0 2 2 2 0 Putative metal-binding domain of cation transport ATPase zf-HYPF PF07503.12 EMC90802.1 - 0.057 13.2 7.4 7.4 6.4 0.1 3.2 3 0 0 3 3 3 0 HypF finger RNA_POL_M_15KD PF02150.16 EMC90802.1 - 0.063 13.2 1.7 0.99 9.3 0.3 2.8 2 1 1 3 3 3 0 RNA polymerases M/15 Kd subunit ADK_lid PF05191.14 EMC90802.1 - 0.073 13.1 5.7 0.31 11.1 1.5 2.8 1 1 1 2 2 2 0 Adenylate kinase, active site lid YhfH PF14149.6 EMC90802.1 - 0.075 13.0 8.4 2.9 7.9 0.0 3.1 3 0 0 3 3 3 0 YhfH-like protein FYDLN_acid PF09538.10 EMC90802.1 - 0.098 13.4 1.2 11 6.8 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) FAM178 PF14816.6 EMC90802.1 - 0.15 11.0 0.2 4.9 6.0 0.1 2.1 1 1 1 2 2 2 0 Family of unknown function, FAM178 zf-CHY PF05495.12 EMC90802.1 - 0.21 12.1 5.5 1.1 9.8 5.5 2.0 1 1 0 1 1 1 0 CHY zinc finger PknG_rubred PF16919.5 EMC90802.1 - 0.26 11.5 4.1 2.3 8.4 0.1 2.3 1 1 1 2 2 2 0 Protein kinase G rubredoxin domain zf-C2H2_11 PF16622.5 EMC90802.1 - 0.3 10.9 0.4 0.3 10.9 0.4 3.1 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-Mss51 PF13824.6 EMC90802.1 - 0.32 11.1 12.0 1.1 9.4 0.3 3.1 1 1 2 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 zinc_ribbon_4 PF13717.6 EMC90802.1 - 0.36 10.8 8.4 5.5 7.0 3.7 2.9 1 1 2 3 3 3 0 zinc-ribbon domain TFIIS_C PF01096.18 EMC90802.1 - 0.36 10.7 6.7 11 6.0 0.1 3.1 3 0 0 3 3 3 0 Transcription factor S-II (TFIIS) zf-C2H2_6 PF13912.6 EMC90802.1 - 0.36 10.9 11.3 0.86 9.7 0.9 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C4_ClpX PF06689.13 EMC90802.1 - 0.36 10.7 0.2 0.36 10.7 0.2 2.3 3 0 0 3 3 2 0 ClpX C4-type zinc finger zf-UBP PF02148.19 EMC90802.1 - 0.56 10.6 6.6 1 9.8 3.6 2.4 1 1 2 3 3 3 0 Zn-finger in ubiquitin-hydrolases and other protein Zn_Tnp_IS1595 PF12760.7 EMC90802.1 - 0.81 9.7 10.4 0.75 9.8 4.4 2.3 1 1 1 2 2 2 0 Transposase zinc-ribbon domain XPA_N PF01286.18 EMC90802.1 - 0.81 9.8 8.0 3.1 7.9 0.1 3.0 3 0 0 3 3 3 0 XPA protein N-terminal zinc_ribbon_2 PF13240.6 EMC90802.1 - 1.5 8.7 11.6 3.6 7.4 0.5 3.2 3 0 0 3 3 3 0 zinc-ribbon domain DUF2256 PF10013.9 EMC90802.1 - 1.9 8.7 5.0 18 5.6 0.1 2.6 3 0 0 3 3 2 0 Uncharacterized protein conserved in bacteria (DUF2256) Zn_ribbon_recom PF13408.6 EMC90802.1 - 2.5 8.7 7.7 29 5.3 0.1 2.6 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain zinc_ribbon_9 PF14369.6 EMC90802.1 - 2.8 8.3 7.2 8.9 6.7 0.3 2.7 3 0 0 3 3 3 0 zinc-ribbon zf-ISL3 PF14690.6 EMC90802.1 - 4 8.2 7.6 3 8.6 0.1 3.0 3 0 0 3 3 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zf-H2C2_2 PF13465.6 EMC90803.1 - 2.3e-08 34.1 6.9 0.00036 20.8 2.0 2.1 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.26 EMC90803.1 - 9.9e-06 25.7 3.4 1.5e-05 25.2 3.4 1.3 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMC90803.1 - 0.00014 22.4 2.4 0.00022 21.8 2.4 1.3 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC90803.1 - 0.0017 18.6 0.2 0.0022 18.3 0.2 1.2 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding LSM PF01423.22 EMC90804.1 - 4.2e-06 26.3 0.0 5e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 LSM domain DUF2986 PF11661.8 EMC90804.1 - 0.063 13.8 2.5 0.08 13.5 2.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2986) Keratin PF02422.16 EMC90805.1 - 1.7e-24 85.3 11.7 1.9e-24 85.2 11.7 1.0 1 0 0 1 1 1 1 Keratin DUF3432 PF11914.8 EMC90805.1 - 0.03 14.6 1.9 0.033 14.4 1.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3432) zf-C2H2 PF00096.26 EMC90806.1 - 6.5e-12 45.2 8.1 1.7e-06 28.1 0.3 2.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMC90806.1 - 2e-10 40.6 13.4 1.7e-09 37.6 1.8 2.4 3 0 0 3 3 2 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMC90806.1 - 3.1e-10 40.0 7.8 1.8e-05 25.2 0.3 2.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMC90806.1 - 6e-09 36.0 3.9 0.00044 20.5 0.1 2.1 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMC90806.1 - 4.1e-08 33.3 5.1 0.0013 19.0 1.7 2.1 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EMC90806.1 - 5.9e-07 29.3 3.7 0.0073 16.3 0.1 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EMC90806.1 - 0.00039 20.1 5.7 0.16 11.8 1.4 2.1 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-LYAR PF08790.11 EMC90806.1 - 0.001 18.9 3.5 0.24 11.3 0.1 2.2 2 0 0 2 2 2 2 LYAR-type C2HC zinc finger zf-Di19 PF05605.12 EMC90806.1 - 0.0026 18.0 1.9 0.0031 17.8 1.9 1.2 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.10 EMC90806.1 - 0.0032 17.5 1.6 0.59 10.3 0.3 2.1 2 0 0 2 2 2 2 Zinc ribbon domain zf-C2H2_8 PF15909.5 EMC90806.1 - 0.0037 17.5 2.5 0.0038 17.5 2.5 1.0 1 0 0 1 1 1 1 C2H2-type zinc ribbon XPA_N PF01286.18 EMC90806.1 - 0.0061 16.6 1.6 0.25 11.4 0.3 2.2 2 0 0 2 2 2 1 XPA protein N-terminal zf_UBZ PF18439.1 EMC90806.1 - 0.0098 15.5 1.7 2.6 7.7 0.0 2.1 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger zf-C2H2_9 PF16293.5 EMC90806.1 - 0.019 14.8 0.3 1.4 8.8 0.0 2.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (1 copy) zinc-ribbons_6 PF07191.12 EMC90806.1 - 0.027 14.4 1.6 0.04 13.9 1.6 1.3 1 1 0 1 1 1 0 zinc-ribbons zinc_ribbon_4 PF13717.6 EMC90806.1 - 0.044 13.7 1.5 1.5 8.8 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain GAGA PF09237.11 EMC90806.1 - 0.054 13.3 3.6 0.068 13.0 2.0 1.8 1 1 0 1 1 1 0 GAGA factor zf-C2H2_2 PF12756.7 EMC90806.1 - 0.058 13.7 3.3 0.31 11.4 0.9 1.9 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) CpXC PF14353.6 EMC90806.1 - 0.12 12.4 2.1 0.36 10.9 0.1 1.9 1 1 1 2 2 2 0 CpXC protein Vps39_2 PF10367.9 EMC90806.1 - 0.16 12.4 1.8 0.73 10.3 0.2 2.0 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 2 zf-Dof PF02701.15 EMC90806.1 - 0.19 11.9 3.2 0.65 10.2 3.2 1.8 1 1 0 1 1 1 0 Dof domain, zinc finger UBZ_FAAP20 PF15750.5 EMC90806.1 - 0.41 10.6 2.8 6.7 6.8 0.2 2.1 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger FYVE PF01363.21 EMC90806.1 - 0.55 10.4 6.0 2.5 8.3 4.5 1.9 1 1 0 1 1 1 0 FYVE zinc finger Keratin PF02422.16 EMC90807.1 - 4.9e-26 90.3 6.9 5.2e-26 90.2 6.9 1.0 1 0 0 1 1 1 1 Keratin # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Chordates/Columba_livia-Cliv_1.0/GCA_000337935.1_Cliv_1.0_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Chordates/Columba_livia-Cliv_1.0/GCA_000337935.1_Cliv_1.0_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Chordates/Columba_livia-Cliv_1.0/GCA_000337935.1_Cliv_1.0_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Chordates/Columba_livia-Cliv_1.0/GCA_000337935.1_Cliv_1.0_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 18:12:11 2019 # [ok]